Protein: Protein farnesyltransferase subunit beta (FTase-beta) (PFTase beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) (G4MY67)
Organism: Pyricularia oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Magnaporthe oryzae)
Function: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The beta subunit is responsible for peptide-binding.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:31250536}.
Sequence: MRHHTKNLRRRAIFLRTTPRGNMDSSSSVATSTSSSSNHRLVRSSEGSPSAGGDDIEEVIMTPGIATGRVQPAVSVAIPDLFTQLPPVKDDLATSTSKTQDETVAICLPYLAGSDANADVEHNAHGVPHIDRKKHVRFLRNMLRQLPAPFIAADASRPWFLYWSLNAMAILGENVKEDYAESLADTARSMQNESGGFSGGHGQTSHLATTYAVVLALAVVGDEEGLSLIDRRALWKWLCDLKEADGGFRMSLGGEEDVRGAYCAAVIISLLNLPLDLCKDSEAYIRDPTANLFTGLGDYVRKCQTFEGGISGQPDAEAHGAYAFCALGCLSLLGTPSETIPKYLNIERLISWLSSRQYAPEGGFSGRTNKLVDGCYSHWVGGCWPLIEACLNGPVKVSSLDVEPQPLFSREGLMRYILCCCQEQGKRGGLRDKPGKPSDAYHSCYVLSGLSSAQNRWQLVVGDDDMPAWMVSPFPNEEEIFDEKDRVGTVHPVYVIPEDKVAKVQTFFASRDGF
InterPro domains: - IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [79-508]
- IPR026872: Protein farnesyltransferase subunit beta (family) [132-453]
- IPR045089: Prenyltransferase subunit beta (family) [130-509]
- IPR001330: Prenyltransferase alpha-alpha toroid domain (domain) [131-496]
Interaction partners: - Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- intramembrane prenyl-peptidase Rce1
- CAAX prenyl protease
- Farnesyl pyrophosphate synthase
- Alkyl transferase
- Hexaprenyl pyrophosphate synthase
- ditrans,polycis-polyprenyl diphosphate synthase [
- Geranylgeranyl pyrophosphate synthetase
- Geranylgeranyl pyrophosphate synthase
- Squalene synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity), GO:0004311 (farnesyltranstransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0051093 (negative regulation of developmental process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0003008 (system process), GO:2000026 (regulation of multicellular organismal development), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009617 (response to bacterium), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0045595 (regulation of cell differentiation), GO:0050877 (nervous system process), GO:1903706 (regulation of hemopoiesis), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0036211 (protein modification process), GO:0030436 (asexual sporulation), GO:0022008 (neurogenesis), GO:0050768 (negative regulation of neurogenesis), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0072359 (circulatory system development), GO:0043068 (positive regulation of programmed cell death), GO:0060284 (regulation of cell development), GO:0007417 (central nervous system development), GO:0051960 (regulation of nervous system development), GO:0010721 (negative regulation of cell development), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0042471 (ear morphogenesis), GO:0050829 (defense response to Gram-negative bacterium), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0070647 (protein modification by small protein conjugation or removal), GO:0035162 (embryonic hemopoiesis), GO:0032446 (protein modification by small protein conjugation), GO:0016925 (protein sumoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:1990234 (transferase complex)