Protein: Platelet glycoprotein Ib alpha chain (GP-Ib alpha) (GPIb-alpha) (GPIbA) (Glycoprotein Ibalpha) (CD antigen CD42b) [Cleaved into: Glycocalicin] (O35930)
Organism: Mus musculus (Mouse)
Function: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MALLILLFLLPSPLHSQHTCSISKVTSLLEVNCENKKLTALPADLPADTGILHLGENQLGTFSTASLVHFTHLTYLYLDRCELTSLQTNGKLIKLENLDLSHNNLKSLPSLGWALPALTTLDVSFNKLGSLSPGVLDGLSQLQELYLQNNDLKSLPPGLLLPTTKLKKLNLANNKLRELPSGLLDGLEDLDTLYLQRNWLRTIPKGFFGTLLLPFVFLHANSWYCDCEILYFRHWLQENANNVYLWKQGVDVKDTTPNVASVRCANLDNAPVYSYPGKGCPTSSGDTDYDDYDDIPDVPATRTEVKFSTNTKVHTTHWSLLAAAPSTSQDSQMISLPPTHKPTKKQSTFIHTQSPGFTTLPETMESNPTFYSLKLNTVLIPSPTTLEPTSTQATPEPNIQPMLTTSTLTTPEHSTTPVPTTTILTTPEHSTIPVPTTAILTTPKPSTIPVPTTATLTTLEPSTTPVPTTATLTTPEPSTTLVPTTATLTTPEHSTTPVPTTATLTTPEHSTTPVPTTATLTTPEPSTTLTNLVSTISPVLTTTLTTPESTPIETILEQFFTTELTLLPTLESTTTIIPEQNSFLNLPEVALVSSDTSESSPFLNSDFCCFLPLGFYVLGLLWLLFASVVLILLLTWTWHVTPHSLDMEQSAALATSTHTTSLEVQRARQVTMPRAWLLFLQGSLPTFRSSLFLWVRPNGRVGPLVAGRRPSALSQGRGQDLLGTVGIRYSGHSL
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [15-292]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [70-210]
- IPR001611: Leucine-rich repeat (repeat) [94-213]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [221-281]
Interaction partners: - Platelet glycoprotein IX
- von Willebrand factor
- Platelet glycoprotein Ib beta chain
- Prothrombin
- P-selectin
- Filamin-A
- Integrin alpha-M
- Platelet glycoprotein V
- Integrin alpha-IIb
- SCO-spondin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0001775 (cell activation), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0050817 (coagulation), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0030168 (platelet activation), GO:0050878 (regulation of body fluid levels), GO:0007596 (blood coagulation), GO:2000145 (regulation of cell motility), GO:0009611 (response to wounding), GO:0098609 (cell-cell adhesion), GO:0002685 (regulation of leukocyte migration), GO:0030155 (regulation of cell adhesion), GO:0045785 (positive regulation of cell adhesion), GO:0042060 (wound healing), GO:0034109 (homotypic cell-cell adhesion), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0002691 (regulation of cellular extravasation), GO:0070527 (platelet aggregation), GO:0007599 (hemostasis), GO:0030334 (regulation of cell migration), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:1904996 (positive regulation of leukocyte adhesion to vascular endothelial cell), GO:1904994 (regulation of leukocyte adhesion to vascular endothelial cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)