Protein: Docking protein 4 (Downstream of tyrosine kinase 4) (Q99KE3)
Organism: Mus musculus (Mouse)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity).
Sequence: MATNFNDIVKQGYVKMKSRKLGIYRRCWLVFRKSSSKGPQRLEKYPDEKSVCLRGCPKVTEISNVKCVTRLPKETKRQAVAIIFTDDSARTFTCDSELEAEEWYKTLSVECLGSRLNDISLGEPDLLAPGVQCEQTDRFNVFLLPCPNLDVYGECKLQITHENIYLWDIHNPRVKLVSWPLCSLRRYGRDATRFTFEAGRMCDAGEGLYTFQTQEGEQIYQRVHSATLAIAEQHKRVLLEMEKNVRLLNKGTEHYSYPCTPTAMLPRSAYWHHITGSQNIAEASSYGESYGAAQASSETDLLNRFILLKPKPSQEDSSEAKTPAQ
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [8-114]
- IPR037816: DOK4/5/6, PH domain (domain) [9-113]
- IPR002404: IRS-type PTB domain (domain) [130-237]
- IPR050996: Docking Protein Family (DOK) (family) [11-269]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [2-235]
Interaction partners: - Proto-oncogene tyrosine-protein kinase receptor Ret
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)