Protein: Neurexin-2-beta (E9PUN2)
Organism: Mus musculus (Mouse)
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion
Subcellular location: Presynaptic cell membrane; Single- pass type I membrane protein
Sequence: MPPGGSGQGGCPRRPPALAGPLPPPPPPPPLPLLLGLLLLLGAAEGARVSSSLSTTHHVHHFHSKHGTVPIAINRMPFLTRSGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSAPGFPRLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV
InterPro domains: - IPR001791: Laminin G domain (domain) [87-295]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [85-288]
- IPR003585: Neurexin/syndecan/glycophorin C (domain) [605-623]
- IPR050372: Neurexin-related cell adhesion and synaptic protein (family) [53-349]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0016247 (channel regulator activity), GO:0005515 (protein binding), GO:0099106 (ion channel regulator activity), GO:0005246 (calcium channel regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0031503 (protein-containing complex localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0044085 (cellular component biogenesis), GO:0048731 (system development), GO:0051649 (establishment of localization in cell), GO:0001505 (regulation of neurotransmitter levels), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0051668 (localization within membrane), GO:0097120 (receptor localization to synapse), GO:0099536 (synaptic signaling), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0099177 (regulation of trans-synaptic signaling), GO:0023061 (signal release), GO:0099645 (neurotransmitter receptor localization to postsynaptic specialization membrane), GO:0050804 (modulation of chemical synaptic transmission), GO:0046903 (secretion), GO:0022607 (cellular component assembly), GO:0006836 (neurotransmitter transport), GO:0007399 (nervous system development), GO:0099643 (signal release from synapse), GO:0099537 (trans-synaptic signaling), GO:0007269 (neurotransmitter secretion), GO:0008104 (protein localization), GO:0099173 (postsynapse organization), GO:0006996 (organelle organization), GO:0034330 (cell junction organization), GO:0072657 (protein localization to membrane), GO:0007416 (synapse assembly), GO:0070925 (organelle assembly), GO:0033365 (protein localization to organelle), GO:0099068 (postsynapse assembly), GO:1902414 (protein localization to cell junction), GO:1903539 (protein localization to postsynaptic membrane), GO:0099171 (presynaptic modulation of chemical synaptic transmission), GO:1990778 (protein localization to cell periphery), GO:0099084 (postsynaptic specialization organization), GO:0034329 (cell junction assembly), GO:0098916 (anterograde trans-synaptic signaling), GO:0050808 (synapse organization), GO:0007268 (chemical synaptic transmission), GO:1904861 (excitatory synapse assembly), GO:0035418 (protein localization to synapse), GO:0097106 (postsynaptic density organization), GO:0099633 (protein localization to postsynaptic specialization membrane), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0098982 (GABA-ergic synapse), GO:0098978 (glutamatergic synapse)