Protein: Interferon-induced GTP-binding protein Mx2 (Myxovirus resistance protein 2) (Q9N0Y2)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15767791}. Nucleus {ECO:0000250}.
Sequence: MSKAHGSRPYRRHNVVIPRQQPEKEMNFVQQQPPPSDAAARQMMYPPNCQVGVQDPVYLAKEFNLLTLNPQQLEGSRHQQMAKGPEKSLYSQYEQKVRPCIDLVDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKRDPHKAWRGRISYRKTELQFQDPSQVEKEIRQAQNIIAGQGLGISHELISLEITSPEVPDLTLIDLPGITRVAVGNQPQDIGVQIKALIKNYIQKQETINLVVVPCNVDIATTEALSMAQEVDPNGDRTIGVLTKPDLVDRGTEKTVVNVAQNLTYHLQKGYMIVRCRGQEEITNQLSLAEATEKERMFFQTHPYFRALLEEGKATVPCLAERLTKELILHINKSLPLLEKQIRESHQRATDELHQCGDSIPSNEADKMFFLIEKIKLFNQDIDKLIEGEEIVKKNETRLYNKIREEFEHWALVLTANTQKVKNIVSEEVSVYEKQYRGKELLGFVNYKTFETIVHQYIEQLVEPALTMLRKTIEIVWQAFTDTAKKHFSVFSNLSQTIQNKIEDIKTRQAETAENLIRLQFRMEQLVYCQDQIYSVVLRKVRKEVFNPAGKAAQDLQLKFPFPKDLPSMSSNDEIGVHLNAYFLETSKRLANQIPFIIQYFVLQENGSCLQKAMMQILQEREQYSWLLQEHADTSAKRRFLKEKIYRLAQARRALYMFFS
InterPro domains: - IPR030381: Dynamin-type guanine nucleotide-binding (G) domain (domain) [115-387]
- IPR000375: Dynamin stalk domain (domain) [307-593]
- IPR020850: GTPase effector domain (domain) [623-711]
- IPR022812: Dynamin (family) [97-706]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [95-403]
- IPR045063: Dynamin, N-terminal (domain) [121-295]
- IPR001401: Dynamin, GTPase domain (domain) [94-387]
- IPR019762: Dynamin, GTPase region, conserved site (conserved_site) [143-152]
- IPR003130: Dynamin GTPase effector (domain) [618-709]
Interaction partners: - ISG15 ubiquitin like modifier.
- Ubiquitin carboxyl-terminal hydrolase
- Interferon-induced, double-stranded RNA-activated protein kinase
- Radical S-adenosyl methionine domain containing 2.
- Interferon induced protein with tetratricopeptide repeats 1.
- 2'-5'-oligoadenylate synthetase 1.
- Signal transducer and activator of transcription.
- 2'-5'-oligoadenylate synthetase 2.
- DExD/H-box helicase 58.
- Intersectin 2.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0006952 (defense response), GO:0051726 (regulation of cell cycle), GO:0051049 (regulation of transport), GO:0043207 (response to external biotic stimulus), GO:0009615 (response to virus), GO:0010033 (response to organic substance), GO:0060341 (regulation of cellular localization), GO:0098542 (defense response to other organism), GO:0034097 (response to cytokine), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus), GO:0032386 (regulation of intracellular transport), GO:0035455 (response to interferon-alpha), GO:0046822 (regulation of nucleocytoplasmic transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)