wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Interleukin-22 (Q9JJY9)
Organism: Mus musculus (Mouse)
Function: Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non- immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN. Promotes epithelial cell spreading
Subcellular location: Secreted
Sequence: MAVLQKSMSFSLMGTLAASCLLLIALWAQEANALPVNTRCKLEVSNFQQPYIVNRTFMLAKEASLADNNTDVRLIGEKLFRGVSAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSNQLSSCHISGDDQNIQKNVRRLKETVKKLGESGEIKAIGELDLLFMSLRNACV
InterPro domains: - IPR020453: Interleukin-22 (family) [1-179]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [29-179]
- IPR020423: Interleukin-10, conserved site (conserved_site) [84-104]
Interaction partners: - Interleukin-22 receptor subunit alpha-1
- Interleukin-10 receptor subunit beta
- Interleukin-22 receptor subunit alpha-2
- Interleukin-22b
- Interleukin-17A
- Interleukin-23 receptor
- Interleukin-20 receptor subunit alpha
- Interleukin-17F
- Interleukin-10
- Interferon gamma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005125 (cytokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0001775 (cell activation), GO:0070661 (leukocyte proliferation), GO:0046649 (lymphocyte activation), GO:0042110 (T cell activation), GO:0032943 (mononuclear cell proliferation), GO:0046651 (lymphocyte proliferation), GO:0042098 (T cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Interleukin-3 receptor subunit alpha (P26951)
Organism: Homo sapiens (Human)
Function: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence: MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
InterPro domains: - IPR040907: IL-3 receptor alpha chain, N-terminal (domain) [27-97]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [105-291]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [101-307]
- IPR003532: Short hematopoietin receptor, family 2, conserved site (conserved_site) [120-151]
- IPR015321: Type I cytokine receptor, cytokine-binding domain (domain) [109-205]
Interaction partners: - Interleukin-3
- Cytokine receptor common subunit beta
- Granulocyte-macrophage colony-stimulating factor
- C-type lectin domain family 4 member C
- Interleukin-5
- GTPase NRas
- GTPase KRas
- GTPase HRas
- Interleukin-2
- B-lymphocyte antigen CD19
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0006955 (immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Interleukin-9 (P15248)
Organism: Homo sapiens (Human)
Function: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites. Affects intestinal epithelial permeability and adaptive immunity. In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5
Subcellular location: Secreted
Sequence: MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI
InterPro domains: - IPR020447: Interleukin-9 (family) [1-144]
- IPR018049: Interleukin-7/Interleukin-9, conserved site (conserved_site) [120-129]
Interaction partners: - Interleukin-9 receptor
- Cytokine receptor common subunit gamma
- Interleukin-7
- Tyrosine-protein kinase JAK3
- Interleukin-4
- Interleukin-5
- Interleukin-2
- Interleukin-6
- Interleukin-15
- Tyrosine-protein kinase JAK1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0070851 (growth factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0006950 (response to stress), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0006952 (defense response), GO:0008284 (positive regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation), GO:0006954 (inflammatory response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Protein IscX (P0C0L9)
Organism: Escherichia coli (strain K12)
Function: May function as iron donor in the assembly of iron-sulfur clusters
Sequence: MGLKWTDSREIGEALYDAYPDLDPKTVRFTDMHQWICDLEDFDDDPQASNEKILEAILLVWLDEAE
InterPro domains: - IPR036762: IscX-like superfamily (homologous_superfamily) [1-66]
- IPR007479: ISC system FeS cluster assembly, IscX (family) [1-66]
Interaction partners: - 2Fe-2S ferredoxin
- 2Fe-2S ferredoxin
- 2Fe-2S ferredoxin
- Co-chaperone protein HscB
- Co-chaperone protein HscB
- Co-chaperone protein HscB
- Chaperone protein HscA
- Chaperone protein HscA
- Iron-sulfur cluster assembly scaffold protein IscU
- Iron-sulfur cluster assembly scaffold protein IscU
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0043167 (ion binding), GO:0140678 (molecular function inhibitor activity), GO:0043169 (cation binding), GO:0004857 (enzyme inhibitor activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0008198 (ferrous iron binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0009067 (aspartate family amino acid biosynthetic process), GO:0006553 (lysine metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0009085 (lysine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Ferric aerobactin receptor (P14542)
Organism: Escherichia coli
Function: Receptor for cloacin DF13/aerobactin
Subcellular location: Cell outer membrane; Multi-pass membrane protein
Sequence: MMISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNMHHIEVIFGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTDGHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIGAGKATSADAFWRLSRLRHFLFNAGLLMHITEPQQAWLNFSQGLELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF
InterPro domains: - IPR010105: TonB-dependent siderophore receptor (family) [46-732]
- IPR010917: TonB-dependent receptor, conserved site (conserved_site) [715-732]
- IPR037066: TonB-dependent receptor, plug domain superfamily (homologous_superfamily) [23-157]
- IPR000531: TonB-dependent receptor-like, beta-barrel (domain) [238-688]
- IPR010916: TonB box, conserved site (conserved_site) [1-38]
- IPR012910: TonB-dependent receptor, plug domain (domain) [45-146]
- IPR039426: TonB-dependent receptor-like (family) [14-732]
- IPR036942: TonB-dependent receptor-like, beta-barrel domain superfamily (homologous_superfamily) [158-732]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015343 (siderophore-iron transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0055080 (monoatomic cation homeostasis), GO:0055072 (iron ion homeostasis), GO:0072337 (modified amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006842 (tricarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009279 (cell outer membrane), GO:0019867 (outer membrane), GO:0030313 (cell envelope)
Protein: D-tagatose-1,6-bisphosphate aldolase subunit KbaY (P0AB74)
Organism: Escherichia coli (strain K12)
Function: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability
Sequence: MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA
InterPro domains: - IPR050246: Class II Fructose-bisphosphate Aldolase (family) [4-282]
- IPR011288: D-tagatose-bisphosphate aldolase, class II, subunit KbaY/GatY (family) [3-284]
- IPR000771: Fructose-bisphosphate aldolase, class-II (family) [1-284]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-286]
- IPR023788: D-tagatose-bisphosphate aldolase, class II, subunit KbaY (family) [1-286]
Interaction partners: - D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- Putative D-galactosamine-6-phosphate deaminase AgaS
- ATP-dependent 6-phosphofructokinase isozyme 1
- D-tagatose-1,6-bisphosphate aldolase subunit GatZ
- D-tagatose-1,6-bisphosphate aldolase subunit GatZ
- ATP-dependent 6-phosphofructokinase isozyme 2
- Putative deaminase AgaI
- L-threonate dehydrogenase
- 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0043169 (cation binding), GO:0016832 (aldehyde-lyase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0022607 (cellular component assembly), GO:0043933 (protein-containing complex organization), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Kelch repeat and BTB domain-containing protein A55 (P24768)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins
Subcellular location: Host cytoplasm
Sequence: MNNSSELIAVINGFRNSGRFCDISIVINDERINAHKLILSGASEYFSILFSNNFIDSNEYEVNLSHLDYQSVNDLIDYIYGIPLSLTNDNVKYILSTADFLQIGSAITECENYILKNLCSKNCIDFYIYADKYNNKKIESASFNTILQNILRLINDENFKYLTEESMIKILSDDMLNIKNEDFAPLILIKWLESTQQSCTVELLRCLRISLLSPQVIKSLYSHQLVSSIYECITFLNNIAFLDESFPRYHSIELISIGISNSHDKISINCYNHKKNTWEMISSRRYRCSFAVAVLDNIIYMMGGYDQSPYRSSKVIAYNTCTNSWIYDIPELKYPRSNCGGLADDEYIYCIGGIRDQDSSLTSSIDKWKPSKPYWQKYAKMREPKCDMGVAMLNGLIYVMGGIVKGDTCTDALESLSEDGWMKHQRLPIKMSNMSTIVHDGKIYISGGYNNSSVVNVISNLVLSYNPIYDEWTKLSSLNIPRINPALWSAHNKLYVGGGISDDVRTNTSETYDKEKDCWTLDNGHVLPRNYIMYKCEPIKHKYPLEKTQYTNDFLKYLESFIGS
InterPro domains: - IPR024182: Vaccinia virus A55R (family) [7-544]
- IPR011705: BTB/Kelch-associated (domain) [123-222]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [1-146]
- IPR000210: BTB/POZ domain (domain) [12-118]
- IPR015915: Kelch-type beta-propeller (homologous_superfamily) [248-530]
- IPR006652: Kelch repeat type 1 (repeat) [258-492]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0019049 (mitigation of host antiviral defense response), GO:0030682 (mitigation of host defenses by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: 3-ketodihydrosphingosine reductase TSC10 (Q59RQ2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the reduction of 3'-oxosphinganine (3- ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Sequence: MWFSKTNFPVEGKTALIVGASQGIGVNLAERLYEKNCSTILVARTESKLQHQIQNIKEKYPESSAKISYAVADVSNYDECTRLWRTIDPADPDILFCCAGSSIPKLFQDLTKVDIESGIDINYKTVINVVHTGFKHALSNNTDNLEPHNFKKRSVVLFSSVVSFFPFIGYSQYAPMKSAIESLSIILRQELSPYNYRVTCVFPGNFQSEGFEEEQKTKPDITKKIEGPSNPIPGDECARLIIDQLDKGYDSITTDFIGWFLGCSVLGISSPRQWGFFQILVSFIVSLIAPIANWFINRDIKNSFKKTKKE
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [6-269]
- IPR045022: 3-ketodihydrosphingosine reductase KDSR-like (family) [12-258]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [13-217]
Interaction partners: - serine C-palmitoyltransferase
- Serine C-palmitoyltransferase
- Sphingolipid delta(4)-desaturase
- Lac1p
- Alkaline dihydroceramidase
- Sphingosine hydroxylase
- Sphingosine N-acyltransferase
- Sphinganine kinase
- Sphinganine kinase
- Utp5p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)