Protein: Fascin (A0A384MEG1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
Sequence: MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
InterPro domains: - IPR022768: Fascin-like domain (domain) [21-493]
- IPR008999: Actin-crosslinking (homologous_superfamily) [11-493]
- IPR024703: Fascin, metazoans (family) [1-493]
- IPR010431: Fascin (family) [75-460]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0003676 (nucleic acid binding), GO:0050839 (cell adhesion molecule binding), GO:0008092 (cytoskeletal protein binding), GO:0003723 (RNA binding), GO:0045296 (cadherin binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048870 (cell motility), GO:0007163 (establishment or maintenance of cell polarity), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048522 (positive regulation of cellular process), GO:0061339 (establishment or maintenance of monopolar cell polarity), GO:0044085 (cellular component biogenesis), GO:0030010 (establishment of cell polarity), GO:0061245 (establishment or maintenance of bipolar cell polarity), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0032970 (regulation of actin filament-based process), GO:0044087 (regulation of cellular component biogenesis), GO:0016477 (cell migration), GO:1903055 (positive regulation of extracellular matrix organization), GO:0043254 (regulation of protein-containing complex assembly), GO:0007015 (actin filament organization), GO:0030030 (cell projection organization), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:1902117 (positive regulation of organelle assembly), GO:0035088 (establishment or maintenance of apical/basal cell polarity), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0032956 (regulation of actin cytoskeleton organization), GO:1903053 (regulation of extracellular matrix organization), GO:0033043 (regulation of organelle organization), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0006996 (organelle organization), GO:0034330 (cell junction organization), GO:0010638 (positive regulation of organelle organization), GO:0061162 (establishment of monopolar cell polarity), GO:1902115 (regulation of organelle assembly), GO:0097435 (supramolecular fiber organization), GO:0060491 (regulation of cell projection assembly), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0010715 (regulation of extracellular matrix disassembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0035089 (establishment of apical/basal cell polarity), GO:0051491 (positive regulation of filopodium assembly), GO:1902745 (positive regulation of lamellipodium organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0051017 (actin filament bundle assembly), GO:0061572 (actin filament bundle organization), GO:0030031 (cell projection assembly), GO:0010592 (positive regulation of lamellipodium assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0045216 (cell-cell junction organization), GO:0034329 (cell junction assembly), GO:1902743 (regulation of lamellipodium organization), GO:0007043 (cell-cell junction assembly), GO:0010591 (regulation of lamellipodium assembly), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0030046 (parallel actin filament bundle assembly), GO:0051489 (regulation of filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0032432 (actin filament bundle), GO:0042641 (actomyosin), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0001726 (ruffle), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0098590 (plasma membrane region), GO:0097517 (contractile actin filament bundle), GO:0001725 (stress fiber), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098858 (actin-based cell projection), GO:0031253 (cell projection membrane), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005911 (cell-cell junction), GO:0002102 (podosome), GO:0030175 (filopodium), GO:1903561 (extracellular vesicle), GO:0005856 (cytoskeleton), GO:0005902 (microvillus), GO:0015629 (actin cytoskeleton)