Protein: Exosome complex exonuclease RRP44p homologue (Q384R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MFTKKRLAVHQVRSSATRRTASGITRNDIGCGTVGCKLCASTACQNSGNSSSLVPTAPIMIPDAVTILHNMNAMEDARIQNIVLLSTVMSEVQERNKAIYARLQRLVGGERKQCYVFSNDRHEQTHCVMQSEETRSDFNDRCVRVAGRWYAQHLALAFPAVTGVAEIPSVVLVSHDKLLQSAPNSAQAEENISNLSCLTLRQFLEGCVTAGTDLLEMIQPDRPVEGKEQGSARALFSPHLAESALDLGVQNGTYLRGKLRVSETNCFFGEIRGQWKGHNFERVLLPGRTNLNRAIHGDIVTVELLPVASWRPLRGAKPTEEMNDTGAGGDDHENSGREGIGEESEGAALARGYTPVGRVVGITTMNRRPFCGSIDVEELNKLADTLDTLTGTVSVLFQPKDNRIPRIRITTAHLGALKDKRLSVIIDDWGEHSSFPVGHYVEVLGTIGDKDTEAKVILLENDIPHYDFSEAVYDCLPKGEWNVTEEELGNRLDLRDLCVVSVDPLGCRDIDDALHCRRVNGNHLEVGVHIADVTHFLKEGTAMDEEAAKRSTSVYLVDRRINMLPQLLTENLCSIVADEDRYAFSIMWEFDENYSVVREFFGKTVIRSRAALYYGDAQRMIDDPEDESEAAVSLRYLMQLSRHFRKRREKDGALFLCSQEFKFKVDNDHVNPTDMQAYQTFDSNSMIEEWMLFANAAAARRVYASFPRWTLLRRHQAPAENAFDTLNEAIRRKIGLKLDDTTSLALNESLEKCVDPSDPYFNRLIRTLVTRCLRQAQYFSSSEVSKDEFHHFGLAMPIYTHFTSPIRRYADVIVHRQLAAALGIMDVSEAHMVSVKMEALASNLNYRHEQAQKAGRDSQNLFTGFYLRNFANQEIPSEDGYVVKLSETHVFVLVPKYGQEGKIAKETLVRVPNLLDKVKVGIEVRQRGDVLRASLVFSIIGLTKGCEDVSEPVAIAGEDLPLKRQRLEEGQQ
InterPro domains: - IPR041505: Dis3-like cold-shock domain 2 (domain) [395-462]
- IPR002716: PIN domain (domain) [61-180]
- IPR022966: Ribonuclease II/R, conserved site (conserved_site) [791-815]
- IPR050180: RNR Ribonuclease (family) [60-904]
- IPR001900: Ribonuclease II/R (domain) [491-824]
- IPR033771: Rrp44-like cold shock domain (domain) [248-312]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [234-869]
Interaction partners: - Exosome component CSL4
- Ribosomal RNA processing protein 45
- Telomerase-associated protein, putative
- RNasePH-like protein exosome-associated protein 1 Rrp42 homologue
- Ribosomal RNA-processing protein 43
- Exosome complex exonuclease RRP40
- Ribosomal RNA processing protein 4
- Elongation factor 1-alpha, putative
- Exosome complex exonuclease RRP41A
- Exosome-associated protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004532 (exoribonuclease activity), GO:0004527 (exonuclease activity), GO:0008408 (3'-5' exonuclease activity), GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters), GO:0016796 (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0000175 (3'-5'-RNA exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0090304 (nucleic acid metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006401 (RNA catabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034661 (ncRNA catabolic process), GO:0034660 (ncRNA metabolic process), GO:0016075 (rRNA catabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)