Protein: Protein odd-skipped-related 2 (zOsr2) (Q567J8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional repressor (By similarity). Required for pronephric kidney development.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q32NK7}.
Sequence: MGSKTLPAPVPLHPAPQLNYSLLRTLNAFPVAVDQLYGLSALHTVQMNRWTVGFPQLQGLADPRFPGALPFPAAAAHLLPHKHPVHRKDRPRFDFANLAVAATQEDPPVTGQSRLSPERRPARGRLPAKSKKEFICRFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHLQTSSLSAAAAAGRCFGATATCGATV
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [134-217]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [131-208]
- IPR050717: C2H2-type Zinc-Finger Transcription Regulators (family) [105-230]
Interaction partners: - Glycosaminoglycan xylosylkinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048736 (appendage development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0072102 (glomerulus morphogenesis), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0072006 (nephron development), GO:0032835 (glomerulus development), GO:0080090 (regulation of primary metabolic process), GO:0048382 (mesendoderm development), GO:0072001 (renal system development), GO:0039021 (pronephric glomerulus development), GO:0007492 (endoderm development), GO:0072009 (nephron epithelium development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0061318 (renal filtration cell differentiation), GO:0001944 (vasculature development), GO:0061005 (cell differentiation involved in kidney development), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1903224 (regulation of endodermal cell differentiation), GO:0033333 (fin development), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0048863 (stem cell differentiation), GO:0061326 (renal tubule development), GO:0072359 (circulatory system development), GO:0072010 (glomerular epithelium development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0060173 (limb development), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0039019 (pronephric nephron development), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0007498 (mesoderm development), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0072080 (nephron tubule development), GO:0048793 (pronephros development), GO:0035850 (epithelial cell differentiation involved in kidney development), GO:0072311 (glomerular epithelial cell differentiation), GO:0072112 (podocyte differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0072073 (kidney epithelium development), GO:0006355 (regulation of DNA-templated transcription), GO:0032925 (regulation of activin receptor signaling pathway), GO:0033339 (pectoral fin development), GO:0039020 (pronephric nephron tubule development), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1900107 (regulation of nodal signaling pathway), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)