Protein: Disease resistance protein RPS2 (Resistance to Pseudomonas syringae protein 2) (Q42484)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Disease resistance (R) protein that specifically recognizes the AvrRpt2 type III effector avirulence protein from Pseudomonas syringae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Acts via its interaction with RIN4, and probably triggers the plant resistance when RIN4 is degraded by AvrRpt2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8986840}. Cell membrane {ECO:0000269|PubMed:12581526}. Note=Not a peripheral membrane protein. Has the biochemical properties of an integral membrane protein without an obvious integral membrane primary structure. {ECO:0000269|PubMed:12581526}.
Sequence: MDFISSLIVGCAQVLCESMNMAERRGHKTDLRQAITDLETAIGDLKAIRDDLTLRIQQDGLEGRSCSNRAREWLSAVQVTETKTALLLVRFRRREQRTRMRRRYLSCFGCADYKLCKKVSAILKSIGELRERSEAIKTDGGSIQVTCREIPIKSVVGNTTMMEQVLEFLSEEEERGIIGVYGPGGVGKTTLMQSINNELITKGHQYDVLIWVQMSREFGECTIQQAVGARLGLSWDEKETGENRALKIYRALRQKRFLLLLDDVWEEIDLEKTGVPRPDRENKCKVMFTTRSIALCNNMGAEYKLRVEFLEKKHAWELFCSKVWRKDLLESSSIRRLAEIIVSKCGGLPLALITLGGAMAHRETEEEWIHASEVLTRFPAEMKGMNYVFALLKFSYDNLESDLLRSCFLYCALFPEEHSIEIEQLVEYWVGEGFLTSSHGVNTIYKGYFLIGDLKAACLLETGDEKTQVKMHNVVRSFALWMASEQGTYKELILVEPSMGHTEAPKAENWRQALVISLLDNRIQTLPEKLICPKLTTLMLQQNSSLKKIPTGFFMHMPVLRVLDLSFTSITEIPLSIKYLVELYHLSMSGTKISVLPQELGNLRKLKHLDLQRTQFLQTIPRDAICWLSKLEVLNLYYSYAGWELQSFGEDEAEELGFADLEYLENLTTLGITVLSLETLKTLFEFGALHKHIQHLHVEECNELLYFNLPSLTNHGRNLRRLSIKSCHDLEYLVTPADFENDWLPSLEVLTLHSLHNLTRVWGNSVSQDCLRNIRCINISHCNKLKNVSWVQKLPKLEVIELFDCREIEELISEHESPSVEDPTLFPSLKTLRTRDLPELNSILPSRFSFQKVETLVITNCPRVKKLPFQERRTQMNLPTVYCEEKWWKALEKDQPNEELCYLPRFVPN
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [483-880]
- IPR055414: Disease resistance R13L4/SHOC-2-like, LRR domain (domain) [556-860]
- IPR042197: Apoptotic protease-activating factors, helical domain (homologous_superfamily) [309-395]
- IPR003593: AAA+ ATPase domain (domain) [174-311]
- IPR050905: Plant disease resistance NBS-LRR (family) [16-868]
- IPR002182: NB-ARC (domain) [159-398]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [142-411]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [396-480]
Interaction partners: - RPM1-interacting protein 4
- Lysine-specific demethylase JMJ29
- Protein NDR1
- Disease resistance protein
- Bromodomain transcription factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0002239 (response to oomycetes), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0002229 (defense response to oomycetes), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)