Protein: Sodium/nucleoside cotransporter 1 (Q9MZT2)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient. Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity. Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit). Involved in renal nucleoside (re)absorption (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein
Sequence: MEKASGRKSLALSTAENGIENAGLELTEEGINSEQTRRMEVQGHSLSDDVRPATHQRSYLQPLTKARTFCQRHASLFKKILLGLLCLAYAAYFLAACILDFQRALALFVITCLVILVLLLHFLKKFLGKKLTRCLKPFKNSQLRLWIKRVFAGVSLVGLILWLALDTAQRPEQLISFAGICMFVLILFACSKHHSAVSWRTVFWGLGLQFVFGLLVIRTDPGFIAFQWLGDQVQIFLAYTVAGSSFVLGDTLVNDVFAFQSLPIIIFFGCVMSILYYLGLVQWVVQKIAWFLQVTMRTTATETLAVAGNIFVGMTEAPLLIRPYLADLTLSEIHAVMTSGFATISGTVLGAFISFGIDASSLISASVMGAPCALALSKLVYPEEEESKFKSKEGVKLPRGKESNVLEAASNGATDAIALVANVAANLVAFLAVLAFINAALSWLGELVDIQGLTFQVICSYILRPMVYMMGVEWTDCPMVAEMVGIKFFTNEFVAYQQLSQYKKKRLSGMEEWIDGQKQWISVRAEVITTFSLCGFANLSSIGITLGGLTSMVPHRKSDLSKVVIRALFTGSCVSFISACVAGILYVPRGAETDCVSFLSTSFTNRSYETYVCCRELFQNTYLNGTNPPSFSGAWEDKAFSAMALANCCGFYNNTVCA
InterPro domains: - IPR018270: Concentrative nucleoside transporter, metazoan/bacterial (family) [174-585]
- IPR011642: Nucleoside transporter/FeoB GTPase, Gate domain (domain) [259-356]
- IPR002668: Concentrative nucleoside transporter N-terminal domain (domain) [178-250]
- IPR008276: Concentrative nucleoside transporter (family) [61-604]
- IPR011657: Concentrative nucleoside transporter C-terminal domain (domain) [362-583]
Interaction partners: - Equilibrative nucleoside transporter 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0005337 (nucleoside transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015851 (nucleobase transport), GO:0006863 (purine nucleobase transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)