Protein: Biogenesis of lysosome-related organelles complex 1 subunit KXD1 (BLOC-1 subunit KXD1) (KxDL homolog) (P53158)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
Subcellular location: Endosome {ECO:0000269|PubMed:14562095}.
Sequence: MVTGISEENDDEETFSAVHSSTPSINSQSYAIPITEEMSSSFHDSISTTSNSSGSFDSDGSNVSDVVEQNEMDNESNVDEDLFLDNDIPQSSNLLPTDAQDPGPIFDVSRYIFDSLKQSIDSADFSEALSLQTKTSAVINSKSLELKQYIDEMKSRLTQLQEKFENGEATSKKIKRDLETSRKNIDYLNAALRVDFPIEFNQAREKILERRLNEDHDC
InterPro domains: - IPR019371: KxDL domain (domain) [115-200]
- IPR051390: Biogenesis of lysosome-related organelles complex 1 subunit KXD1 (family) [10-210]
Interaction partners: - Biogenesis of lysosome-related organelles complex 1 subunit BLI1
- Biogenesis of lysosome-related organelles complex 1 subunit VAB2
- Biogenesis of lysosome-related organelles complex 1 subunit CNL1
- Biogenesis of lysosome-related organelles complex 1 subunit SNN1
- Biogenesis of lysosome-related organelles complex 1 subunit BLS1
- Kelch repeat-containing protein 3
- Membrane protein TMS1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0032006 (regulation of TOR signaling), GO:0032007 (negative regulation of TOR signaling), GO:0032008 (positive regulation of TOR signaling), GO:1904263 (positive regulation of TORC1 signaling), GO:1903432 (regulation of TORC1 signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005667 (transcription regulator complex), GO:0090575 (RNA polymerase II transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070847 (core mediator complex), GO:0005634 (nucleus)