Protein: LIM/homeobox protein ttx-3 (Abnormal thermotaxis protein 3) (G5EE86)
Organism: Caenorhabditis elegans
Function: Transcription factor (Probable). Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-10, ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY neurons, and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. In concert with WNT/beta-catenin signaling, initiates expression of homeobox ceh-10 in AIY, but not in the sister cells, SMDD motor neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:9292724}. Perikaryon {ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:9292724}. Cell projection, axon {ECO:0000269|PubMed:11493519, ECO:0000269|PubMed:9292724}.
Sequence: MYFQSLSADPLDSVNTTTDFNQLAQLLLMLTNSSSKETIATHVVTNSVPSAFQFDWSSHFKEEYDLVEKLNSPQYTNLTSISPSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVVDGKYYHNNCLRCQMCDIPFEYSDKCYVRDGVFLCRADHAKRYQKCCRKCEIPLNREDMVMKAKEMIFHHACFVCFICGIKLNPGDYYTMSPQGHLYCHAHYNAVRSTVLCEEAAVATVPAVVAPPPPPPTTTTAPPPAAPEQPPREASTEAEASTDEDGNGSGSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAKDLKQLAAKTNLTKRVLQVWFQNARAKYRRELHDGGRSSSPLCVSAPLASMDMNPPLSSSSSGHSTDGYQLNTPPLSSEIYSPNSNYTHL
InterPro domains: - IPR001356: Homeodomain (domain) [290-354]
- IPR050453: LIM/homeobox transcription factors (family) [94-381]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [281-349]
- IPR017970: Homeobox, conserved site (conserved_site) [325-348]
- IPR001781: Zinc finger, LIM-type (domain) [108-232]
Interaction partners: - LIM interaction domain-containing protein
- Homeobox protein ceh-10
- Serpentine receptor class alpha-11
- Transcription factor unc-86
- Transcription factor unc-3
- Transcription factor che-1
- Transcription factor ast-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0019098 (reproductive behavior), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0040012 (regulation of locomotion), GO:0007610 (behavior), GO:0045165 (cell fate commitment), GO:0008038 (neuron recognition), GO:0040028 (regulation of vulval development), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0018991 (oviposition), GO:0001708 (cell fate specification), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0040026 (positive regulation of vulval development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007413 (axonal fasciculation), GO:0007399 (nervous system development), GO:0030334 (regulation of cell migration), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120036 (plasma membrane bounded cell projection organization), GO:0106030 (neuron projection fasciculation), GO:0061564 (axon development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)