Protein: Transcription elongation factor SPT6-like (Q9CAM1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription elongation factor that enhances the transcription elongation by RNA polymerase II (RNAPII).
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MNRIDEEPQIHEDPVENREEDDEDEDDQYEFDDGFLVNGSDDGEEEEEQRHCSEKKSRSRRKKDESFTLHEDDYLLLKDNNDTFQRNKYKRLKKSSEEEDKINNDDDDDDLSHFIVDEDDHGAQGMRRKKMKYKQGTDSNALRYANDVFGDPEELLKLRKKDLKYNEKIERKLEDEFEPMVLSEKYMTEKDDEIRKLDVPERMQIFEEAIGIVSLDDMSIQEESNWIYARLLQEQGQGCLINKDDIVKFLEMFHVQKLEIPFIAMYRKEQCRSLLDSSDDDHDGSDFNLDKKLETKWHKVLWMIQDLDRKWVLLRKRKTALFGYYTKRFEEETCMSDLNKSLFESVIKSLQAAETEREVDDVDSKFNLHFPHCEIDEGQYKRPNRKSQYSICSKFGIKEFANKFGYSAEQLGLALSLEKVFVDELEDAKKTPEEMALNYECAMFGDSQAVLKGARHMAAVEISCEPSIRKYVRGIFMENAVVSTSPTPDGNVVIDSFHRFSAVKWLSEKPLRKFDGVQWLLIQKAEEEKLLQVTFKLPENQMNRIISECSEHYLSVGVSKYAQLWNEQRKLILEDAVHGFVLPSMEKEARSLLTSRAKTQLLSEYGQVLWNKVSSGPYRRNNNTSEEEAAPRVLACCWGPGNPETTFVMLDSSGELVDVLYSGSIGLRSRDVNDQKRKKMDQDRFLKFIRDHQPDVLALAAVNLSCVRLKDEIYEAIFQMVEELPLNYVDDRIYDFPLVYADESLPRLYENSRISSEQLPQQAGIVKRAVSLGRYLQNPLAMISTLCGPGRDILSWKLHSFQDFLDPDEKYEMVEQVMVDITNQVGIDINLAASHEWLFSPLQFVSGLGPRKAASLQKSLVRAGSIFVRKELINHGIGKKVFVNAAGFLRIRRSGLACSSSQFIDLLDDTRIHPESYGLAQELAKDVYAHDTVRGDEDDAIEMAIEHVRDEPASLRKIVLDEYLRSKNQENKKETYSLIMRELSCGFQDWRSLFKEVDSDEEFYMISGETKETIGEGRIVQATVKKVTSGKAKCVLDCGLPGILLKEDYSDDGRDIVDLSNKLCEGDIVTCKVKSILKQRYHVLLVCKESEMRKHRNLGDVDDYYHEEKRNSVLIEKEKVPKEKKQFKSRMIVHPRFQNITAEQATVYLSDKNIGESIVRPSSRGLNHLTLMIKISDNVYANKEIIEGEKENKDIVSLQRIGKTLKIGNETFEDLDEVMDRYVDPLVTHLMTMLNHRKFRTGTKSEIDDLLRVEKGVNPKMVVYSFGVSHEHPGSFILSYIRSANPHHEYIGLYPKGFKFRKRMFGDLDKLAAYFKRHIDNQ
InterPro domains: - IPR042066: Spt6, Death-like domain (homologous_superfamily) [900-990]
- IPR028231: Transcription elongation factor Spt6, YqgF domain (domain) [630-786]
- IPR032706: Transcription elongation factor Spt6, helix-hairpin-helix motif (domain) [791-891]
- IPR035420: Spt6, SH2 domain (domain) [1106-1318]
- IPR023319: Tex-like protein, HTH domain superfamily (homologous_superfamily) [210-387]
- IPR003029: S1 domain (domain) [1015-1088]
- IPR028083: Spt6 acidic, N-terminal domain (domain) [17-97]
- IPR041692: HHH domain 9 (domain) [906-932]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [631-787]
- IPR006641: YqgF/RNase H-like domain (domain) [631-750]
- IPR037027: YqgF/RNase H-like domain superfamily (homologous_superfamily) [626-1010]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [1012-1122]
- IPR010994: RuvA domain 2-like (homologous_superfamily) [801-991]
- IPR023323: Tex-like domain superfamily (homologous_superfamily) [388-825]
- IPR017072: Transcription elongation factor Spt6 (family) [1-1322]
- IPR035018: Spt6, SH2 domain, C terminus (domain) [1233-1319]
- IPR035019: Spt6, SH2 domain, N terminus (domain) [1134-1222]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [1120-1322]
- IPR049540: Spt6-like, S1/OB domain (domain) [1003-1089]
- IPR055179: Tex-like, central region (domain) [428-598]
Interaction partners: - FACT complex subunit SSRP1
- FACT complex subunit
- FACT complex subunit SPT16
- Protein CTR9 homolog
- Protein IWS1 homolog 2
- Protein IWS1 homolog 1
- Protein CDC73 homolog
- Protein LEO1 homolog
- Protein RTF1 homolog
- Transcription elongation factor SPT4 homolog 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0009790 (embryo development), GO:0048608 (reproductive structure development), GO:0009793 (embryo development ending in seed dormancy), GO:0048731 (system development), GO:0061458 (reproductive system development), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0055044 (symplast), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction)