Protein: Calcium-binding protein 4 (CaBP4) (P57796)
Organism: Homo sapiens (Human)
Function: Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19338761}. Presynapse {ECO:0000250|UniProtKB:Q8VHC5}. Note=Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors. {ECO:0000250|UniProtKB:Q8VHC5}.
Sequence: MTTEQARGQQGPNLAIGRQKPPAGVVTPKSDAEEPPLTRKRSKKERGLRGSRKRTGSSGEQTGPEAPGSSNNPPSTGEGPAGAPPASPGPASSRQSHRHRPDSLHDAAQRTYGPLLNRVFGKDRELGPEELDELQAAFEEFDTDRDGYISHRELGDCMRTLGYMPTEMELLEVSQHIKMRMGGRVDFEEFVELIGPKLREETAHMLGVRELRIAFREFDRDRDGRITVAELREAVPALLGEPLAGPELDEMLREVDLNGDGTVDFDEFVMMLSRH
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [124-274]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [142-268]
- IPR002048: EF-hand domain (domain) [129-275]
- IPR043582: Calcium binding protein 1/2/4/5 (family) [34-274]
Interaction partners: - Voltage-dependent L-type calcium channel subunit alpha-1F
- Protein S100-G
- Nyctalopin
- Metabotropic glutamate receptor 6
- Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
- Voltage-dependent L-type calcium channel subunit alpha-1D
- Probable G-protein coupled receptor 179
- C-terminal-binding protein 2
- Protein S100-A6
- Sodium/potassium/calcium exchanger 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0007267 (cell-cell signaling), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051049 (regulation of transport), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0032409 (regulation of transporter activity), GO:0044092 (negative regulation of molecular function), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0034762 (regulation of transmembrane transport), GO:0051098 (regulation of binding), GO:0034763 (negative regulation of transmembrane transport), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0032410 (negative regulation of transporter activity), GO:0043271 (negative regulation of monoatomic ion transport), GO:0007166 (cell surface receptor signaling pathway), GO:0043271 (negative regulation of monoatomic ion transport), GO:0051284 (positive regulation of sequestering of calcium ion), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0048666 (neuron development), GO:0032413 (negative regulation of ion transmembrane transporter activity), GO:0022008 (neurogenesis), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0007399 (nervous system development), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0044091 (membrane biogenesis), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:0030182 (neuron differentiation), GO:1901020 (negative regulation of calcium ion transmembrane transporter activity), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:1904063 (negative regulation of cation transmembrane transport), GO:0010959 (regulation of metal ion transport), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:1903170 (negative regulation of calcium ion transmembrane transport), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:1904063 (negative regulation of cation transmembrane transport), GO:0010959 (regulation of metal ion transport), GO:0051924 (regulation of calcium ion transport), GO:2001257 (regulation of cation channel activity), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport), GO:1901385 (regulation of voltage-gated calcium channel activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0001750 (photoreceptor outer segment), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0097381 (photoreceptor disc membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0005929 (cilium), GO:0097730 (non-motile cilium), GO:0097733 (photoreceptor cell cilium), GO:0097731 (9+0 non-motile cilium)