Protein: Osteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein) (P04640)
Organism: Rattus norvegicus (Rat)
Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P86546}.
Sequence: MRTLSLLTLLALTAFCLSDLAGAKPSDSESDKAFMSKQEGSKVVNRLRRYLNNGLGAPAPYPDPLEPHREVCELNPNCDELADHIGFQDAYKRIYGTTV
InterPro domains: - IPR035972: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily (homologous_superfamily) [62-97]
- IPR000294: Gamma-carboxyglutamic acid-rich (GLA) domain (domain) [31-96]
- IPR002384: Osteocalcin/matrix Gla protein (family) [66-95]
- IPR039176: Osteocalcin (family) [3-98]
Interaction partners: - SPARC
- Osteopontin
- Runt-related transcription factor 2
- Tumor necrosis factor ligand superfamily member 11
- Vitamin K-dependent gamma-carboxylase
- Parathyroid hormone
- Bone morphogenetic protein 2
- G-protein coupled receptor family C group 6 member A
- Integrin-binding sialoprotein
- Aggrecan core protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0048306 (calcium-dependent protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0009991 (response to extracellular stimulus), GO:0001666 (response to hypoxia), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009612 (response to mechanical stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0072001 (renal system development), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0071453 (cellular response to oxygen levels), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:1901699 (cellular response to nitrogen compound), GO:0014070 (response to organic cyclic compound), GO:0001822 (kidney development), GO:1901701 (cellular response to oxygen-containing compound), GO:0048678 (response to axon injury), GO:1901653 (cellular response to peptide), GO:0071375 (cellular response to peptide hormone stimulus), GO:0001656 (metanephros development), GO:0032869 (cellular response to insulin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix)