Protein: Tyrosine-protein kinase receptor (A0A0H2UKW5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein
Sequence: MDVWLCSAVPVFTWRLFFLSSIFQGYWSSMLDCPPTCSCSPTEIYCNKSDVGNFFPLLALQESAGNGSNNNDIEELFRNITSIHIENWTGLQILRDVDMELYTGLQRLTIINCNLRQIQPRAFSRNPHLRYINLSRNPLASLSWQLFQHLQLVELRLEGVVFDCGCKIRWIQLWRLRGEAGLHTQQLYCKDGASKISLRSMSIAHCDLQDISVAHSNLTVLEGGNVTLSCNGSGSPVPEVDWAVKGLHSINTHQSTVYLPNTHSINLTLVNVSRDDNGFVLTCISENVVGMNNVSLQLSVLFPPVILKLDEPERRHHTCIEFTVRGFPHPTLHWFYKGREILQSEYIRMEMDYYKDYLEGCLTFENPTHYDNGNYTLVATNSLGSVSKTVFGHFLDPPFMEDDAPPPEDEGKRPEDSFGMSIAVGLAGFGCVFLIVIFVLINKYSRRNKFGIKGPVAVISGEEDSASPLHHVNHGIVTPCSLDAGPDAVVIGMSRIPVIENPQYFRHGHNCNKPTTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKTLKDPTLTARKDFQREAELLTNLQHEHIVKFYGVCVDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPMQSNGELGLSQMLHIATQIAAGMVYLSSQHFVHRDLATRNCLVGNGLLVKIGDFGMSRDIYSSDYYRVGGHTMLPIRWMPPESIMYRKFSTESDVWSFGVIMWEIFTYGKQPWFHLSNNEVIECITQGRVLDRPRLCPKEVYDLMLGCWQREPQQRLNIKDIQKVLYALGKATPVYLDILG
InterPro domains: - IPR020777: Growth factor receptor NTRK (family) [98-377]
- IPR007110: Immunoglobulin-like domain (domain) [209-299]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [526-798]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [210-409]
- IPR031635: Growth factor receptor NTRK, leucine rich repeat C-terminal (domain) [163-207]
- IPR003599: Immunoglobulin domain subtype (domain) [215-391]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [212-398]
- IPR002011: Tyrosine-protein kinase, receptor class II, conserved site (conserved_site) [691-699]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [527-798]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [217-295]
- IPR017441: Protein kinase, ATP binding site (binding_site) [532-560]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [663-675]
- IPR013098: Immunoglobulin I-set (domain) [321-390]
- IPR050122: Receptor Tyrosine Kinase (family) [220-798]
- IPR003598: Immunoglobulin subtype 2 (domain) [221-290]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [501-799]
- IPR001611: Leucine-rich repeat (repeat) [104-159]
- IPR000719: Protein kinase domain (domain) [526-808]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [33-197]
Interaction partners: - Neurotrophin-7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)