Protein: adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylyl cyclase) (Q57VY0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MTSLLSKLSLPLLQLLFLLLSFSTTGRAEDNTTINVLSLMYSPDVQEVEVDSLNAGFDASLTARGWKTNSKARVSFIRPPSYDTPVAEFFESVVKESEGKLMIVFGPFGGPNTMWVKGELSKHGAVSFGPLAFSTEVREWDPHLYFISVEPNAELLALFRYAVVFLGLPRVGITYLKGTPSGEALYEFALEISSMMGHELCGAFAAAGGVGADEDALAAEWNQFVETRPQAVLLFAPVRNPATEWFIGRIVKDERTRQMYVLAPSTSQGPLIRTWRDALYASNVSLNDGQLIITGTIPPSNLLTLASVRRFREEMDNHLKSNSEWGGFSKPPHFSTDEAISDLMMTGWLTGEILSQALHSTDVLTDRTAFMDSLYRQRRYVVDDLVVGDYGNECGEFASMQGAMCNCNQGGSAVYMKEVVDGFRIEPLQRGFLAWGASQCSSRDVKISIPLSGFVMHLSDYFFSYRSAKRWYEGVSSAPVIRDDFGEDILHFDVLPLSTQMGVIALEALLNMREIVIIYGAVDEDILELPGPVFVDPLLLYPRINRFNRNVLLLSPTVRQQLYVLAMHLSNASTGAVSAAIRSKRAEVIGDVLNKSLMTFDVALKSMLLLKESDTLVDHLPSSGDVVAIGLTPPDAHAIAQYLQSRNDRRVYVLFSEVAQLYDEFVEAFNATPAAVVSASRLVFATNLPHWADKNTESDTVAMFHAYNPRESTWTPLRLRGFATARLLRSIVPRMKRISPSLLVDFFYTESNIRVDDMHYGPYSDVECVKGRVTAANRCETNFGAGNISVWSMSRVLDPRVPVLSRGVTPSLEYAVMDESSLSPSQLAGIIVGSVFFVALAIALCVLLCLFVRVRGQRDTVPKSSSDLVTFINDSEVCVPMFEMLRGGECGVVTIVCTDIESSTAQWSTHPELMPDAVLAHHTMIRSLIMQYGCYEVKTVGDSFMIACRSTSTAVELASDIQRSFLQHCWGTTVFDDFYRNSEMQKAEDDDHYIPPSARLDPEVYRQLWNGLRVRIGIHTGLCDIRHDEVTKGYDYYGRTPNMAARTESVTNGGQVLLTYAAYMSLSTEERDQLDATSLGPVALRGVPEPIVMYQLNAVPGRAFTGLRLDRGFYFDEDVENFSFSSNSLSFDSLKLSGSAQTISDALHSLLSTFKPPQRERLLALYCERWNVPLPMGGSYAWDDAYCEEVIRRIAVKVGPFVGRYAS
InterPro domains: - IPR057399: Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 1 (domain) [153-295]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [886-1115]
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [719-1097]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [98-378]
- IPR057398: Receptor-type adenylate cyclase GRESAG 4.1/3, periplasmic binding protein-like domain 2 (domain) [449-815]
- IPR050697: Adenylyl/Guanylyl Cyclase Class-3/4 (family) [16-1200]
Interaction partners: - Nitrogen permease regulator 2
- 3', 5'-cyclic nucleotide phosphodiesterase, putative
- Phosphodiesterase
- Phosphodiesterase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0019932 (second-messenger-mediated signaling), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0019933 (cAMP-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097542 (ciliary tip), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)