Protein: Translation initiation factor eIF2B subunit epsilon (eIF2B GDP-GTP exchange factor subunit epsilon) (Q8CHW4)
Organism: Mus musculus (Mouse)
Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287}.
Sequence: MAATAAVPGAAAGRASKRGGGGSGGGGTQGAEEEPPPPLQAVLVADSFNRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQKSKWCHPTSPNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLIYGDVISNINICRALEEHRLRRKLEKNVSVMTMVFKESSPSHPTRCHEDNVVMAVDSATNRVLHFQKTQGLRRFSFPLSLFQGSGDGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGILMNEEVLGNQIHLHVTTREYGARVSNLHMYSAVCADVIRRWVYPLTPEVNFTDSTTQSYTHSRHNIYRGPEVSLGHGSVLEENVLLGAGTVIGSNCSITNSVIGPNCHIGDNVVLDQAYLWQGVRVAAGAQIHQSLLCDRAEVKERVKLKPYCVLTSQVVVGPDITLPEGSVISLHPPDAEEDEDDGQFSDDSGADQEKEKVKLKGYNPAEVGLEGQGYLWKAEGVNSKEDEELRQSLWGLMIKTEEESETESEGSVDPEELDSRAGSPQLDDIRVFQNEVLGTLQRGREENISCENLVLEINSLKHAYNISLKEVMQVLTLVVLEFPLQQVDGLLDPNRYCALLLPLLKAWSPVLRNYIKRAADHLEALAAIEDFFLEHETLVTSMAKVLMAFYQLEILAEETILSWFSQRDTTDEGQQLRKNQQLQRFIQWLREAEEESSEDD
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [548-710]
- IPR051956: eIF2B Complex Subunit Epsilon (family) [29-717]
- IPR003307: W2 domain (domain) [539-716]
- IPR035543: Translation initiation factor eIF-2B subunit epsilon, N-terminal (domain) [39-253]
- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [28-386]
- IPR044123: Translation initiation factor eIF-2B subunit epsilon, W2 domain (domain) [544-707]
- IPR011004: Trimeric LpxA-like superfamily (homologous_superfamily) [277-445]
Interaction partners: - Translation initiation factor eIF2B subunit alpha
- Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit beta
- Translation initiation factor eIF2B subunit gamma
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 3, X-linked
- Eukaryotic translation initiation factor 2 subunit 3, Y-linked
- E3 ubiquitin-protein ligase ARIH1
- RNA cytosine C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0090079 (translation regulator activity, nucleic acid binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0003676 (nucleic acid binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0008135 (translation factor activity, RNA binding), GO:0030695 (GTPase regulator activity), GO:0003743 (translation initiation factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0048584 (positive regulation of response to stimulus), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0007272 (ensheathment of neurons), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0046660 (female sex differentiation), GO:0009266 (response to temperature stimulus), GO:0002764 (immune response-regulating signaling pathway), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0044249 (cellular biosynthetic process), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009408 (response to heat), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0006413 (translational initiation), GO:0033554 (cellular response to stress), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0001541 (ovarian follicle development), GO:0007548 (sex differentiation), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0061458 (reproductive system development), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0006518 (peptide metabolic process), GO:0042552 (myelination), GO:0008406 (gonad development), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0043604 (amide biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0034976 (response to endoplasmic reticulum stress), GO:0022008 (neurogenesis), GO:0006412 (translation), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0007399 (nervous system development), GO:0046545 (development of primary female sexual characteristics), GO:0007417 (central nervous system development), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0008585 (female gonad development), GO:0043043 (peptide biosynthetic process), GO:0014003 (oligodendrocyte development), GO:0048709 (oligodendrocyte differentiation), GO:0014002 (astrocyte development), GO:0050851 (antigen receptor-mediated signaling pathway), GO:0042063 (gliogenesis), GO:0048708 (astrocyte differentiation), GO:0050852 (T cell receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005851 (eukaryotic translation initiation factor 2B complex), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)