Protein: Cadherin-2 (Neural cadherin) (N-cadherin) (Parachute) (ZNCAD) (Q90275)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21115806}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15116}. Cell junction {ECO:0000269|PubMed:10456847}. Cell surface {ECO:0000250|UniProtKB:P15116}. Cell junction, desmosome {ECO:0000250|UniProtKB:P15116}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P15116}.
Sequence: MYPSGGVMLGLLAALQVAVQGTGAMPCQPGFTENEYNVMTADVITEGQVLLKVDFVDCGRGSGLRFESGDPADFRIDADGTVMAARTLQLTDRKGQSLEIKAKDENSQEQWMVHINFTQPKQVPVILFPRHSVLVKGDDSVNRVKRDWVIPPVNVLENSRKQFPEELVKIQSDKDKSNTLRYSVTGPGADQNPTGLFIIDPISGLLSVTKPLDREHIPNFHLRAHAVDINGNQMENPIDIIINVIDMNDNRPEFTHQIWNGTVDEGAKPGTFVMTVTSQDKDDPNTANGMLRYKILSQTPESPSSNMFTINNKTGKIITVAAGLDREKVPQYTLIIQATDMEGNPTYGLSNTATAVIRLLDVNDNAPEFTRETFHGEVPENRVNVIVTNLTVTDKDEPGTPAWNAVYRIISGDPTGRFSIPTDPVTNEGLVTVVKPVDFEMNRSFMLTVVADNEVPLASGIHRTRQSTATVSIRVIDVNESPNFDPNPKQIKLEEGLPQWSMLTTFTAHDPDRYMQQTISYSKLYDPANWLEIDPNNGRISTIAVLDRESPYVKNNLYNATFMASDNGVPRASGTGTLQIYLLDINDNAPRVFPQEAEVCERPEPNAINITAVDGDLNPNAGPYAFELPNRPSDIRRNWTLTRISGDHAQLSLKISYLESGIYELPISITDSGNLPMSNTTYLRIKVCQCDHHGDCVDMERIMAAGLGTGAIIAILICIIILLVLVLMFVMWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTLEPDMIKPVGIRRLDERPMHSEPNYPIRSAAPHPGDIGEFIHEGLKAADTDPTAPPYDSLLVFDYEGSGSTAGSLSSLHSSSSGGDQDYDYLNDWGPRFRKLADMYGGNDD
InterPro domains: - IPR014868: Cadherin prodomain (domain) [26-119]
- IPR027397: Catenin binding domain superfamily (homologous_superfamily) [799-893]
- IPR002126: Cadherin-like (domain) [153-702]
- IPR000233: Cadherin, Y-type LIR-motif (domain) [830-889]
- IPR039808: Cadherin (family) [61-890]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [27-692]
- IPR020894: Cadherin conserved site (conserved_site) [357-590]
Interaction partners: - Catenin beta-1
- Junction plakoglobin a.
- Actin alpha 1, skeletal muscle b.
- Cadherin 1, type 1, E-cadherin
- Protocadherin-19
- Gap junction alpha-1 protein
- Catenin alpha-2
- Catenin alpha-1
- Zinc finger protein SNAI2
- Tight junction protein 1a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0050840 (extracellular matrix binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0007163 (establishment or maintenance of cell polarity), GO:0007155 (cell adhesion), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0048729 (tissue morphogenesis), GO:0030010 (establishment of cell polarity), GO:0035148 (tube formation), GO:0098609 (cell-cell adhesion), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0090132 (epithelium migration), GO:0035295 (tube development), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0008354 (germ cell migration), GO:0048382 (mesendoderm development), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0007492 (endoderm development), GO:0060562 (epithelial tube morphogenesis), GO:0021915 (neural tube development), GO:0043954 (cellular component maintenance), GO:0007369 (gastrulation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0002009 (morphogenesis of an epithelium), GO:0016331 (morphogenesis of embryonic epithelium), GO:0001667 (ameboidal-type cell migration), GO:0072175 (epithelial tube formation), GO:0022008 (neurogenesis), GO:0055113 (epiboly involved in gastrulation with mouth forming second), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0007398 (ectoderm development), GO:0007498 (mesoderm development), GO:0060429 (epithelium development), GO:0034330 (cell junction organization), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0042074 (cell migration involved in gastrulation), GO:0001702 (gastrulation with mouth forming second), GO:0034331 (cell junction maintenance), GO:0001841 (neural tube formation), GO:0048699 (generation of neurons), GO:0045216 (cell-cell junction organization), GO:0034332 (adherens junction organization), GO:0045217 (cell-cell junction maintenance), GO:0090504 (epiboly), GO:0034334 (adherens junction maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0019897 (extrinsic component of plasma membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0005886 (plasma membrane), GO:0098858 (actin-based cell projection), GO:0016342 (catenin complex), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction), GO:0005902 (microvillus)