Protein: Calsyntenin-2 (Q9ER65)
Organism: Mus musculus (Mouse)
Function: May modulate calcium-mediated postsynaptic signals.
Subcellular location: Postsynaptic cell membrane {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:24613359}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12498782}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:12498782}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. {ECO:0000269|PubMed:12498782}.
Sequence: MLPGRLCLVPLLLALGVGSGGGSGDGGDSRRRRLLVAKVNKHKPWIETSYHGVITENNDTVILDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEYTFIIQAYDCGAGPREAAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAIVTEGKIYDSILQVEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQKPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQVTAELQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDGRQGAKIPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHNCRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLVTNDWPIHPSHIAMQLTVGACWQGGEVAKPRFAQFFHGSLASLTIRPGKMESQKVISCLQACKEGLDINSLESLGRGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRRLRLSSKVQCFGEDVCISIPDVDAYIMVLQAIEPQITLQGTERFWRPAAQFESARGVTLFPDIKIVSTFAKTEASGDMRATGTAPKSAVLEEMLHNLDFCDILVLGGDLDPRQECLELNHSELHQRHLDATNSTAGYSIYGVGSMNRYEQVLHHLRYRNWHPTSLETRRFRIKCSELNGRYTSNEFNLEVSVLHEVRVSDKEHVNHLIVQPPFLQSVHHPETRSSIQRSSVVPSIATVVIIISVCMLVFVVAMGVYRVRIAHQHFIQETEAAKEAEMDWDDSALTITVNPMEKHEGPGNGEDETTEVEEEEEAEEGSSSSSSGSDDSEEEEEEGMGRVRHGQSGTSSQSPERSTWNTAGVINIWK
InterPro domains: - IPR045588: Calsyntenin, C-terminal (domain) [548-896]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [332-543]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [39-269]
- IPR002126: Cadherin-like (domain) [45-282]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050773 (regulation of dendrite development), GO:0045597 (positive regulation of cell differentiation), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0001558 (regulation of cell growth), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0010033 (response to organic substance), GO:0045184 (establishment of protein localization), GO:0044087 (regulation of cellular component biogenesis), GO:0055082 (intracellular chemical homeostasis), GO:2000026 (regulation of multicellular organismal development), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0045595 (regulation of cell differentiation), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0034599 (cellular response to oxidative stress), GO:0072001 (renal system development), GO:0009743 (response to carbohydrate), GO:0043254 (regulation of protein-containing complex assembly), GO:0071705 (nitrogen compound transport), GO:0031344 (regulation of cell projection organization), GO:0071310 (cellular response to organic substance), GO:1901888 (regulation of cell junction assembly), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0010001 (glial cell differentiation), GO:0071702 (organic substance transport), GO:0051960 (regulation of nervous system development), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0006886 (intracellular protein transport), GO:0007399 (nervous system development), GO:0031346 (positive regulation of cell projection organization), GO:0015031 (protein transport), GO:0030516 (regulation of axon extension), GO:0007417 (central nervous system development), GO:0008104 (protein localization), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:1901701 (cellular response to oxygen-containing compound), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0032006 (regulation of TOR signaling), GO:0010770 (positive regulation of cell morphogenesis involved in differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0032007 (negative regulation of TOR signaling), GO:0071322 (cellular response to carbohydrate stimulus), GO:0071333 (cellular response to glucose stimulus), GO:0034284 (response to monosaccharide), GO:0051897 (positive regulation of protein kinase B signaling), GO:0034284 (response to monosaccharide), GO:0042063 (gliogenesis), GO:0042886 (amide transport), GO:0010769 (regulation of cell morphogenesis involved in differentiation), GO:0015833 (peptide transport), GO:0002790 (peptide secretion), GO:0045687 (positive regulation of glial cell differentiation), GO:0031175 (neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0050775 (positive regulation of dendrite morphogenesis), GO:0015849 (organic acid transport), GO:0031401 (positive regulation of protein modification process), GO:0030072 (peptide hormone secretion), GO:0009746 (response to hexose), GO:0071326 (cellular response to monosaccharide stimulus), GO:0010975 (regulation of neuron projection development), GO:0071331 (cellular response to hexose stimulus), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0098984 (neuron to neuron synapse), GO:0098982 (GABA-ergic synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane)