Protein: Rae-1-like protein (C5IXG6)
Organism: Rattus norvegicus (Rat)
Function: Acts as a ligand for KLRK1
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Sequence: MEGGVQAPSLTGRPSRVAVILTEGQASYKVPDNCWSYSVGDRHFRESLSGILCGAAQNPHGFSQLRSHLLLRAGMAENTAAEHPLFTGASCVLVFLSCLGSTLCADVHSLSCNLIIRSPTKAEPLWYEGQCSMDGNVFLSSNNVNKTMPLGNQEKMANATEVWTCLTQWIDRCKQDLRDKVSEIKGDTTKTSGHPTLRVTMLSNHSHEQIIGASCVFNISENYSFILDLKTMKWKLINPVPEDIMKEWKDDKTLMKHLNLFIVECSPKFNEFLNQHEERTRSTTRAPDITQPPPTSQVPYKEVLIPVGLIISIIFIIFLCICVKRMCCPHGGRELQLLKDYCINWHKPQRNEGLEETKGEVPNQRTKMLSQEEDPKTLGGPRRASESVELELQMFSSTGS
InterPro domains: - IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [106-278]
- IPR029287: Retinoic acid early-inducible protein 1 (domain) [106-278]
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [100-284]
- IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [106-279]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046703 (natural killer cell lectin-like receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048584 (positive regulation of response to stimulus), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0080134 (regulation of response to stress), GO:0031343 (positive regulation of cell killing), GO:0032101 (regulation of response to external stimulus), GO:0031341 (regulation of cell killing), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0050778 (positive regulation of immune response), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0031347 (regulation of defense response), GO:0002837 (regulation of immune response to tumor cell), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0002834 (regulation of response to tumor cell), GO:0002836 (positive regulation of response to tumor cell), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0002839 (positive regulation of immune response to tumor cell), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity), GO:0002717 (positive regulation of natural killer cell mediated immunity), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0002715 (regulation of natural killer cell mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)