Protein: Muscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein) (Q5FW52)
Organism: Mus musculus (Mouse)
Function: Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD.
Subcellular location: Nucleus {ECO:0000269|PubMed:21498514, ECO:0000269|PubMed:22343712, ECO:0000269|PubMed:26436652, ECO:0000269|PubMed:33802236}. Nucleus envelope {ECO:0000269|PubMed:21498514}. Nucleus, PML body {ECO:0000269|PubMed:21498514}. Cytoplasm, cytosol {ECO:0000269|PubMed:21498514, ECO:0000269|PubMed:22343712, ECO:0000269|PubMed:26436652}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26359501}; Peripheral membrane protein {ECO:0000269|PubMed:26359501}; Cytoplasmic side {ECO:0000269|PubMed:26359501}.
Sequence: MTSCILAGSLETTPKVSPGDPEAKPLIFTFVPTLRRLPTHIQLADTSKFLVKIPEEPTDKSPETVNRFEYSDHMTFSSESKQERVQRILDYPSEVSGRNSQQKEFNTKEPQGMQKGDLFKAEYVFIVDSDGEDEATCRQGEQGPPGGPGNIATRPKSLAISSSLASDVVRPKVRGADLKTSSHPEIPHGIAPQQKHGLLISPTTSEQLAHKPPAFSFVSPTNQKTPPVPANVSGATVLREFHTRRLDVTGASEEETTTYFHSTAHDSPLSAWKGASTLVVSPSAQLSGSSLCGSNVTDHTRGLASEAQKKMSTSNVLNPKEDVRTCPAPASGASLTSPSASYIPVRIVMHSLSPSPKPLTSSSHGSLSTVCSQMSSSGSLSKSGLKSPVPSRLSLLTAILKSNPSHQRPLSPASCPTFSLNSLASSTLALDQKVKQTPPTSKKSLSSGSLTTGSTEQEHQASAASYQPCHLPFFSKTTPLSQAQPLSPLALASNSCASMDIEKIPGSTLRSNTTSPQPQTDTFSLADVPSVTPVLSPLSSSKGRKDGDSRTPEKNRNICIQPSTLASTPPVDESLALSSSGKGFHPSPALSDLIDRSKRACSQQHPGQRPSPSALPTPPVSRAASASHPHLGCSILPLQSSLTQTLQPSPSALRPSCGSATCPSRTQMPENTASNHSSRVSTPSLPVSLTRTKELFSPCALSMSAGPENKKPKQYKTMSSYKAFAAIPTNTLLLEQKALDEPARTESNSKASVLDLPVEFCFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRPPQTMLGSETIKTPTTHPRAAGRETKYANLSSSSSTASESQLTKPGVIRPVPVKSKLLLRKDEEVYEPNPFSKYLEDNSGLFSEQDMAIPHKPVSLHPLYQSKLYPPAKSLLHPQTLSHADCLTPGSFSHLSSFSVRDEQEKSPTLLSQDTYNKLGHPMVTIPEHDTLDSKE
InterPro domains: - IPR029331: Muscular LMNA-interacting protein (family) [2-967]
Interaction partners: - Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor 1C
- Cyclin-dependent kinase inhibitor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0071840 (cellular component organization or biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)