Protein: Beta-1 adrenergic receptor (Beta-1 adrenoreceptor) (Beta-1 adrenoceptor) (P18090)
Organism: Rattus norvegicus (Rat)
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:12391161}; Multi-pass membrane protein {ECO:0000269|PubMed:12391161}. Early endosome {ECO:0000250}. Note=Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression (By similarity). Colocalizes with RAPGEF2 at the plasma membrane. {ECO:0000250}.
Sequence: MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
InterPro domains: - IPR002233: Adrenoceptor family (family) [113-380]
- IPR000507: Beta 1 adrenoceptor (family) [12-443]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [75-366]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [60-380]
Interaction partners: - Natriuretic peptides A
- Beta-2 adrenergic receptor
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
- Guanine nucleotide-binding protein G
- Pro-glucagon
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide
- Guanine nucleotide-binding protein G
- Beta-3 adrenergic receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0004935 (adrenergic receptor activity), GO:0004936 (alpha-adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:1900047 (negative regulation of hemostasis), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0032504 (multicellular organism reproduction), GO:0051050 (positive regulation of transport), GO:0050879 (multicellular organismal movement), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0044706 (multi-multicellular organism process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0048583 (regulation of response to stimulus), GO:0007585 (respiratory gaseous exchange by respiratory system), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:1900046 (regulation of hemostasis), GO:0007568 (aging), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0032879 (regulation of localization), GO:0003008 (system process), GO:0042698 (ovulation cycle), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0050818 (regulation of coagulation), GO:0001666 (response to hypoxia), GO:0010942 (positive regulation of cell death), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0030155 (regulation of cell adhesion), GO:0003014 (renal system process), GO:0032101 (regulation of response to external stimulus), GO:0008217 (regulation of blood pressure), GO:0034764 (positive regulation of transmembrane transport), GO:0030193 (regulation of blood coagulation), GO:0044849 (estrous cycle), GO:0003016 (respiratory system process), GO:0030279 (negative regulation of ossification), GO:1901343 (negative regulation of vasculature development), GO:0003013 (circulatory system process), GO:0009725 (response to hormone), GO:0031348 (negative regulation of defense response), GO:0099536 (synaptic signaling), GO:0050878 (regulation of body fluid levels), GO:0050866 (negative regulation of cell activation), GO:0007162 (negative regulation of cell adhesion), GO:0007611 (learning or memory), GO:0002026 (regulation of the force of heart contraction), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0043270 (positive regulation of monoatomic ion transport), GO:0042391 (regulation of membrane potential), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0007166 (cell surface receptor signaling pathway), GO:0050865 (regulation of cell activation), GO:0090066 (regulation of anatomical structure size), GO:0030278 (regulation of ossification), GO:0048638 (regulation of developmental growth), GO:0008284 (positive regulation of cell population proliferation), GO:0048639 (positive regulation of developmental growth), GO:0030195 (negative regulation of blood coagulation), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0009611 (response to wounding), GO:1901863 (positive regulation of muscle tissue development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0034762 (regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0043462 (regulation of ATP-dependent activity), GO:0003012 (muscle system process), GO:0050881 (musculoskeletal movement), GO:2000026 (regulation of multicellular organismal development), GO:0007565 (female pregnancy), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0050819 (negative regulation of coagulation), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:1903524 (positive regulation of blood circulation), GO:0050877 (nervous system process), GO:0099177 (regulation of trans-synaptic signaling), GO:0031099 (regeneration), GO:1901861 (regulation of muscle tissue development), GO:1903035 (negative regulation of response to wounding), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0010765 (positive regulation of sodium ion transport), GO:0045823 (positive regulation of heart contraction), GO:0061045 (negative regulation of wound healing), GO:1901654 (response to ketone), GO:0060078 (regulation of postsynaptic membrane potential), GO:0071453 (cellular response to oxygen levels), GO:0008015 (blood circulation), GO:0043067 (regulation of programmed cell death), GO:0010543 (regulation of platelet activation), GO:0022407 (regulation of cell-cell adhesion), GO:0006936 (muscle contraction), GO:0048732 (gland development), GO:0048545 (response to steroid hormone), GO:0099565 (chemical synaptic transmission, postsynaptic), GO:0043627 (response to estrogen), GO:0071869 (response to catecholamine), GO:1903522 (regulation of blood circulation), GO:0031100 (animal organ regeneration), GO:0048641 (regulation of skeletal muscle tissue development), GO:0051928 (positive regulation of calcium ion transport), GO:0036293 (response to decreased oxygen levels), GO:0031644 (regulation of nervous system process), GO:0022408 (negative regulation of cell-cell adhesion), GO:0032781 (positive regulation of ATP-dependent activity), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0071456 (cellular response to hypoxia), GO:0003018 (vascular process in circulatory system), GO:0050890 (cognition), GO:0050728 (negative regulation of inflammatory response), GO:1903034 (regulation of response to wounding), GO:0043068 (positive regulation of programmed cell death), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0050804 (modulation of chemical synaptic transmission), GO:1901342 (regulation of vasculature development), GO:0035809 (regulation of urine volume), GO:0045777 (positive regulation of blood pressure), GO:0007612 (learning), GO:0061008 (hepaticobiliary system development), GO:0035150 (regulation of tube size), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0050905 (neuromuscular process), GO:0042060 (wound healing), GO:0043268 (positive regulation of potassium ion transport), GO:0010243 (response to organonitrogen compound), GO:0050727 (regulation of inflammatory response), GO:0003073 (regulation of systemic arterial blood pressure), GO:0033993 (response to lipid), GO:0003009 (skeletal muscle contraction), GO:0099537 (trans-synaptic signaling), GO:0045765 (regulation of angiogenesis), GO:0010544 (negative regulation of platelet activation), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0042981 (regulation of apoptotic process), GO:0071548 (response to dexamethasone), GO:0090330 (regulation of platelet aggregation), GO:0031960 (response to corticosteroid), GO:1904064 (positive regulation of cation transmembrane transport), GO:0099171 (presynaptic modulation of chemical synaptic transmission), GO:0010959 (regulation of metal ion transport), GO:0035811 (negative regulation of urine volume), GO:0071867 (response to monoamine), GO:0006941 (striated muscle contraction), GO:0097746 (blood vessel diameter maintenance), GO:0032570 (response to progesterone), GO:0008016 (regulation of heart contraction), GO:0098916 (anterograde trans-synaptic signaling), GO:0001889 (liver development), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0035296 (regulation of tube diameter), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0097421 (liver regeneration), GO:0034110 (regulation of homotypic cell-cell adhesion), GO:0061041 (regulation of wound healing), GO:0034111 (negative regulation of homotypic cell-cell adhesion), GO:0043065 (positive regulation of apoptotic process), GO:0051931 (regulation of sensory perception), GO:1904427 (positive regulation of calcium ion transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)