Protein: Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) (P01143)
Organism: Rattus norvegicus (Rat)
Function: Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:6603620}.
Sequence: MRLRLLVSAGMLLVALSPCLPCRALLSRGSVSGAPRAPQPLNFLQPEQPQQPQPILIRMGEEYFLRLGNLNRSPAARLSPNSTPLTAGRGSRPSHDQAAANFFRVLLQQLQMPQRPLDSSTELAERGAEDALGGHQGALERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
InterPro domains: - IPR000187: Corticotropin-releasing factor (domain) [146-185]
- IPR003620: Urocortin/corticotropin-releasing factor (family) [1-187]
- IPR018446: Corticotropin-releasing factor conserved site (conserved_site) [148-163]
Interaction partners: - Corticotropin-releasing factor receptor 1
- Corticotropin-releasing factor receptor 2
- Corticotropin-releasing factor-binding protein
- Urocortin-2
- Urocortin
- Urocortin 3.
- Pro-opiomelanocortin
- Pro-neuropeptide Y
- Oxytocin-neurophysin 1
- Pro-thyrotropin-releasing hormone
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity), GO:0005184 (neuropeptide hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:1905954 (positive regulation of lipid localization), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0044706 (multi-multicellular organism process), GO:0044703 (multi-organism reproductive process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0032370 (positive regulation of lipid transport), GO:1905952 (regulation of lipid localization), GO:0044057 (regulation of system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0010817 (regulation of hormone levels), GO:0046883 (regulation of hormone secretion), GO:0007565 (female pregnancy), GO:2000833 (positive regulation of steroid hormone secretion), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:1903532 (positive regulation of secretion by cell), GO:0050890 (cognition), GO:2000831 (regulation of steroid hormone secretion), GO:0002793 (positive regulation of peptide secretion), GO:0010628 (positive regulation of gene expression), GO:0044060 (regulation of endocrine process), GO:0032368 (regulation of lipid transport), GO:0010468 (regulation of gene expression), GO:0019932 (second-messenger-mediated signaling), GO:0007613 (memory), GO:2000848 (positive regulation of corticosteroid hormone secretion), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0019218 (regulation of steroid metabolic process), GO:0050796 (regulation of insulin secretion), GO:0019722 (calcium-mediated signaling), GO:0002791 (regulation of peptide secretion), GO:0043950 (positive regulation of cAMP-mediated signaling), GO:0043949 (regulation of cAMP-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)