Protein: Sorbitol dehydrogenase (SDH) (XDH) (EC 1.1.1.14) (EC 1.1.1.9) (L-iditol 2-dehydrogenase) (Polyol dehydrogenase) (Xylitol dehydrogenase) (F7A1C3)
Organism: Equus caballus (Horse)
Function: Not known
Subcellular location: Mitochondrion membrane {ECO:0000256|RuleBase:RU369026}; Peripheral membrane protein {ECO:0000256|RuleBase:RU369026}. Cell projection, cilium, flagellum {ECO:0000256|RuleBase:RU369026}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000256|RuleBase:RU369026}.
Sequence: MAAAKSENLSVVVHGPGDLRLENYLIPEPGPNEVLLKMHSVGICGSDVHYWEHGRIGHFVVKKPMVLGHEASATVVKVGSLVQHLKPGDRVAIEPGAPRETDEFCKIGRYNLSPSIFFCATPPDDGNLCRFYKHNASFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGNKVFVCGAGPIGLVTLLVAKAMGAAQVVVTDLSASRLSKAKELGADFILHISKESPQEIASKVEDLLGCKPEVTIECTGAEAAIQAGIYATRSGGTLVLVGLGSEMTTVPLVHAATREVDIKGVFRYCNTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMLKCDPDDQNP
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [145-315]
- IPR020843: Enoylreductase domain (domain) [15-347]
- IPR045306: Sorbitol dehydrogenase-like (family) [10-349]
- IPR013149: Alcohol dehydrogenase-like, C-terminal (domain) [182-311]
- IPR011032: GroES-like superfamily (homologous_superfamily) [9-180]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [30-144]
Interaction partners: - Aldo-keto reductase family 1 member B1
- Hexokinase 1.
- Xylulose kinase
- hexokinase
- Hexokinase-3
- Ketohexokinase
- Hexokinase-2
- L-xylulose reductase
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0000166 (nucleotide binding), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:1901265 (nucleoside phosphate binding), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0017076 (purine nucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0051287 (NAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044282 (small molecule catabolic process), GO:0044283 (small molecule biosynthetic process), GO:0044248 (cellular catabolic process), GO:0006066 (alcohol metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0019318 (hexose metabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0019400 (alditol metabolic process), GO:0019751 (polyol metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0016052 (carbohydrate catabolic process), GO:0006059 (hexitol metabolic process), GO:0006006 (glucose metabolic process), GO:0019405 (alditol catabolic process), GO:0019319 (hexose biosynthetic process), GO:0046174 (polyol catabolic process), GO:0006000 (fructose metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)