Protein: Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) (Q8IVN8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20551380}.
Sequence: MRTLWMALCALSRLWPGAQAGCAEAGRCCPGRDPACFARGWRLDRVYGTCFCDQACRFTGDCCFDYDRACPARPCFVGEWSPWSGCADQCKPTTRVRRRSVQQEPQNGGAPCPPLEERAGCLEYSTPQGQDCGHTYVPAFITTSAFNKERTRQATSPHWSTHTEDAGYCMEFKTESLTPHCALENWPLTRWMQYLREGYTVCVDCQPPAMNSVSLRCSGDGLDSDGNQTLHWQAIGNPRCQGTWKKVRRVDQCSCPAVHSFIFI
InterPro domains: - IPR056801: SBSPON-like, C-terminal (domain) [148-257]
- IPR036024: Somatomedin B-like domain superfamily (homologous_superfamily) [35-76]
- IPR039942: Somatomedin-B and thrombospondin type-1 domain-containing protein (family) [4-263]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [74-133]
- IPR001212: Somatomedin B domain (domain) [24-75]
- IPR044004: Spondin-like TSP1 domain (domain) [75-122]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [72-122]
Interaction partners: - Hydroxysteroid dehydrogenase-like protein 2
- Beta-alanine-activating enzyme
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0001818 (negative regulation of cytokine production), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:1901343 (negative regulation of vasculature development), GO:0044087 (regulation of cellular component biogenesis), GO:0043086 (negative regulation of catalytic activity), GO:0043254 (regulation of protein-containing complex assembly), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0051336 (regulation of hydrolase activity), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:1902531 (regulation of intracellular signal transduction), GO:0060491 (regulation of cell projection assembly), GO:0043087 (regulation of GTPase activity), GO:0043408 (regulation of MAPK cascade), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0051346 (negative regulation of hydrolase activity), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0043410 (positive regulation of MAPK cascade), GO:0051345 (positive regulation of hydrolase activity), GO:0030030 (cell projection organization), GO:0043547 (positive regulation of GTPase activity), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)