Protein: tRNA (cytosine(38)-C(5))-methyltransferase (EC 2.1.1.204) (DNA (cytosine-5)-methyltransferase-like protein 2) (Q9VKB3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MVFRVLELFSGIGGMHYAFNYAQLDGQIVAALDVNTVANAVYAHNYGSNLVKTRNIQSLSVKEVTKLQANMLLMSPPCQPHTRQGLQRDTEDKRSDALTHLCGLIPECQELEYILMENVKGFESSQARNQFIESLERSGFHWREFILTPTQFNVPNTRYRYYCIARKGADFPFAGGKIWEEMPGAIAQNQGLSQIAEIVEENVSPDFLVPDDVLTKRVLVMDIIHPAQSRSMCFTKGYTHYTEGTGSAYTPLSEDESHRIFELVKEIDTSNQDASKSEKILQQRLDLLHQVRLRYFTPREVARLMSFPENFEFPPETTNRQKYRLLGNSINVKVVGELIKLLTIK
InterPro domains: - IPR001525: C-5 cytosine methyltransferase (family) [3-345]
- IPR050750: Cytosine-specific C5-methyltransferase (family) [3-343]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [3-342]
- IPR031303: DNA methylase, C-5 cytosine-specific, conserved site (conserved_site) [324-342]
Interaction partners: - tRNA
- 28S rRNA
- Queuine tRNA-ribosyltransferase catalytic subunit
- Methyl-CpG binding domain protein-like, isoform C
- Endoribonuclease Dcr-2
- tRNA
- Pseudouridylate synthase 7 homolog
- N
- S-adenosylmethionine synthase
- G/T mismatch-specific thymine DNA glycosylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0140097 (catalytic activity, acting on DNA), GO:0009008 (DNA-methyltransferase activity), GO:0008173 (RNA methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0140101 (catalytic activity, acting on a tRNA), GO:0003886 (DNA (cytosine-5-)-methyltransferase activity), GO:0008175 (tRNA methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0008340 (determination of adult lifespan), GO:0032259 (methylation), GO:0048584 (positive regulation of response to stimulus), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0048583 (regulation of response to stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0009266 (response to temperature stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0006979 (response to oxidative stress), GO:0046483 (heterocycle metabolic process), GO:0080134 (regulation of response to stress), GO:0032101 (regulation of response to external stimulus), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009408 (response to heat), GO:0002831 (regulation of response to biotic stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:0050776 (regulation of immune response), GO:0006139 (nucleobase-containing compound metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0050778 (positive regulation of immune response), GO:0009790 (embryo development), GO:0031349 (positive regulation of defense response), GO:0044260 (cellular macromolecule metabolic process), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0001510 (RNA methylation), GO:0006306 (DNA methylation), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0050688 (regulation of defense response to virus), GO:0006259 (DNA metabolic process), GO:0010467 (gene expression), GO:0030488 (tRNA methylation), GO:0050691 (regulation of defense response to virus by host), GO:0016070 (RNA metabolic process), GO:0006304 (DNA modification), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0034470 (ncRNA processing), GO:0006400 (tRNA modification), GO:0002230 (positive regulation of defense response to virus by host), GO:0006305 (DNA alkylation), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010494 (cytoplasmic stress granule), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005634 (nucleus)