Protein: Pre-mRNA-splicing factor SYF1 (Adapter protein ATH-55) (XPA-binding protein 2) (Q99PK0)
Organism: Rattus norvegicus (Rat)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:12801913}. Note=Detected in the splicing complex carrying pre-mRNA. {ECO:0000269|PubMed:12801913}.
Sequence: MVVMARVPRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEFKQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERAFVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHPLPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNYQLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKARDVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARFEQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATGKPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYDEALKLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYDRILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFISRYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYDRATRAVEPAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEIDRARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIREMLRIRRSVQATYNTQVNFMASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPPRAQSKIFFVRSDASREELAELAQQANPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED
InterPro domains: - IPR003107: HAT (Half-A-TPR) repeat (repeat) [48-713]
- IPR056350: Pre-mRNA-splicing factor SYF1, central HAT repeats domain (domain) [181-385]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [24-749]
- IPR055430: Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain (domain) [387-774]
- IPR045075: Pre-mRNA-splicing factor Syf1-like (family) [18-775]
- IPR019734: Tetratricopeptide repeat (repeat) [256-466]
- IPR055433: Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain (domain) [20-178]
Interaction partners: - Peptidyl-prolyl cis-trans isomerase E
- Pre-mRNA-splicing factor ISY1 homolog
- Pre-mRNA-splicing factor SYF2
- Protein BUD31 homolog
- Pre-mRNA-processing factor 19
- RNA helicase aquarius
- Cell division cycle 5-like protein
- SNW domain-containing protein 1
- Pre-mRNA-splicing factor RBM22
- 116 kDa U5 small nuclear ribonucleoprotein component
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010976 (positive regulation of neuron projection development), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0120114 (Sm-like protein family complex), GO:0030532 (small nuclear ribonucleoprotein complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0097525 (spliceosomal snRNP complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005685 (U1 snRNP), GO:0005634 (nucleus)