Protein: Cytidine deaminase (CDA) (EC 3.5.4.5) (Cytidine aminohydrolase) (Q06549)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Sequence: MKVGGIEDRQLEALKRAALKACELSYSPYSHFRVGCSILTNNDVIFTGANVENASYSNCICAERSAMIQVLMAGHRSGWKCMVICGDSEDQCVSPCGVCRQFINEFVVKDFPIVMLNSTGSRSKVMTMGELLPMAFGPSHLN
InterPro domains: - IPR016193: Cytidine deaminase-like (homologous_superfamily) [3-142]
- IPR050202: Cytidine and Deoxycytidylate Deaminase (family) [11-140]
- IPR016192: APOBEC/CMP deaminase, zinc-binding (binding_site) [61-103]
- IPR002125: Cytidine and deoxycytidylate deaminase domain (domain) [9-139]
- IPR006262: Cytidine deaminase, homotetrameric (family) [13-141]
Interaction partners: - Uridine nucleosidase
- Cytosine deaminase
- Uridine kinase
- Deoxycytidylate deaminase
- Putative uridine kinase DAS2
- tRNA-specific adenosine deaminase subunit TAD3
- Purine nucleoside phosphorylase
- tRNA-specific adenosine deaminase subunit TAD2
- Bifunctional protein RIB2
- Bifunctional purine biosynthesis protein ADE16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0019239 (deaminase activity), GO:0004126 (cytidine deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044282 (small molecule catabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0043094 (cellular metabolic compound salvage), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901575 (organic substance catabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0043174 (nucleoside salvage), GO:0044270 (cellular nitrogen compound catabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:1901565 (organonitrogen compound catabolic process), GO:0034404 (nucleobase-containing small molecule biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019439 (aromatic compound catabolic process), GO:0009116 (nucleoside metabolic process), GO:0046700 (heterocycle catabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008655 (pyrimidine-containing compound salvage), GO:1901136 (carbohydrate derivative catabolic process), GO:0018130 (heterocycle biosynthetic process), GO:1901361 (organic cyclic compound catabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901657 (glycosyl compound metabolic process), GO:0034656 (nucleobase-containing small molecule catabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:1901659 (glycosyl compound biosynthetic process), GO:0006213 (pyrimidine nucleoside metabolic process), GO:0009164 (nucleoside catabolic process), GO:1901658 (glycosyl compound catabolic process), GO:0009163 (nucleoside biosynthetic process), GO:0009119 (ribonucleoside metabolic process), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0072529 (pyrimidine-containing compound catabolic process), GO:0042455 (ribonucleoside biosynthetic process), GO:0046135 (pyrimidine nucleoside catabolic process), GO:0042454 (ribonucleoside catabolic process), GO:0046131 (pyrimidine ribonucleoside metabolic process), GO:0046133 (pyrimidine ribonucleoside catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)