Protein: Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) (P98197)
Organism: Mus musculus (Mouse)
Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (By similarity). Does not show flippase activity toward phosphatidylcholine (PC) (By similarity). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29799007}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:P98196}. Recycling endosome {ECO:0000250|UniProtKB:P98196}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P98196}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. {ECO:0000250|UniProtKB:P98196}.
Sequence: MDCSLLRTLVRRYCAGEENWVDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNEKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVCGREREELFFRAICLCHTVQVKDDHCGDDVDGPQKSPDAKSCVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEILNRENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVRSRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQSAKVALQDREKKLAEAYEQIEKDLVLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLEEQSLHDVLFDLSKTVLRCSGSMTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDIAKNALLRWRVFIYWTFLGVFDALVFFFGAYFIFENTTVTINGQMFGNWTFGTLVFTVMVLTVTLKLALDTHYWTWINHFVIWGSLLFYIAFSLLWGGVIWPFLSYQRMYYVFISMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWPTATERTQNIQHQDSISEFTPLASLPSWGAQGSRLLAAQCSSPSGRVVCSRWESEECPVLPLHPGLPHKARYGCCRSSLEMPT
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [129-277]
- IPR001757: P-type ATPase (family) [95-907]
- IPR032630: P-type ATPase, C-terminal (domain) [854-1106]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [418-667]
- IPR036412: HAD-like superfamily (homologous_superfamily) [407-881]
- IPR006539: P-type ATPase, subfamily IV (family) [470-1110]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [395-876]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [414-420]
- IPR023214: HAD superfamily (homologous_superfamily) [659-864]
- IPR032631: P-type ATPase, N-terminal (domain) [42-96]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [43-1105]
Interaction partners: - Cell cycle control protein 50A
- Cell cycle control protein 50B
- Phospholipid-transporting ATPase IF
- Phospholipid-transporting ATPase VA
- Phospholipid-transporting ATPase IB
- Phospholipid-transporting ATPase IA
- Cell cycle control protein 50C
- Phospholipid-transporting ATPase VB
- Phospholipid-transporting ATPase ID
- Phospholipid-transporting ATPase IC
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0060998 (regulation of dendritic spine development), GO:0050773 (regulation of dendrite development), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0060999 (positive regulation of dendritic spine development), GO:0045595 (regulation of cell differentiation), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0022604 (regulation of cell morphogenesis), GO:0061003 (positive regulation of dendritic spine morphogenesis), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0048814 (regulation of dendrite morphogenesis), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0010770 (positive regulation of cell morphogenesis involved in differentiation), GO:0010769 (regulation of cell morphogenesis involved in differentiation), GO:0099175 (regulation of postsynapse organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050767 (regulation of neurogenesis), GO:0050775 (positive regulation of dendrite morphogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)