Protein: Epithelial splicing regulatory protein 1 (A1L1G1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity)
Subcellular location: Nucleus
Sequence: MTVNPDYLVLLFTTTSGASGDKLGSDEKEIVQLVWQVVDLATKKAGQVNELLVKPDHIELSEECQELSGLTDEALTPVDPLEVAIDQLNQRLCAEVDTGAGNTFYLCTDGQLHVRQVLHPEASSKNILLPDCFFSFFDLRKEFKKEFPSEVKLKDLNLQVMADHLNVAVDSSLHAFTAYKVQQMVDIVLALISEPTCHEFTFPEKVNEKFETGTCSKMERVDDNTVIRARGLPWQSSDQDIARFFRGLNIAKGGAALCLNAQGRRNGEALVRFESEEHRDLALQRHKHHMGGRYIEVYKATGEDFLKIAGGTSNEVASFLSRENQIIVRMRGLPFNATAEQVLQFFSPACPVTDGSEGILFVRFPDGRPTGDAFVLFSCEEHAQNALKKHKDMLGKRYIELFKSTAAEVQQVLNKYSSAPLIPVAPSPILSVVAPPTFVPQTAAVPGVRDCVRLRGLPYDASIQDILVFLGEYGADIKTHGVHMVLNHQGRPSGEAFIQMRSAERAFLAAQRCHKRSMKERYVEVFACSAQEVNIVLMGGTLNRSGLSPPPCLSPPSYTFPHGAPVLPAGAVLPAGAVLPVESAGIYPSQFLLGPRPPPHTTTFYPASNTLYMNYTTYYPSPPGSPSNISYFPTGHTPSAGSVLSAQPTALIRMQGHAHSHAYNNGVKEILSMVQGYQPGNSDAFVTFPSMLSAKQPIGDQTVGGGAYLDLQLL
InterPro domains: - IPR050666: Epithelial Splicing Regulatory (family) [217-528]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [3-197]
- IPR034427: ESRP1, RNA recognition motif 1 (domain) [216-308]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [220-532]
- IPR013520: Ribonuclease H-like domain (domain) [6-191]
- IPR000504: RNA recognition motif domain (domain) [225-526]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [5-174]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [215-540]
Interaction partners: - Protein enabled homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007389 (pattern specification process), GO:0009790 (embryo development), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0009880 (embryonic pattern specification), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)