Protein: C-C motif chemokine 2 (Immediate-early serum-responsive protein JE) (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Small-inducible cytokine A2) (P14844)
Organism: Rattus norvegicus (Rat)
Function: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:23955712}.
Sequence: MQVSVTLLGLLFTVAACSIHVLSQPDAVNAPLTCCYSFTGKMIPMSRLENYKRITSSRCPKEAVVFVTKLKREICADPNKEWVQKYIRKLDQNQVRSETTVFYKIASTLRTSAPLNVNLTHKSEANASTLFSTTTSSTSVEVTSMTEN
InterPro domains: - IPR039809: Chemokine beta/gamma/delta (family) [4-93]
- IPR000827: CC chemokine, conserved site (conserved_site) [34-76]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [27-113]
- IPR001811: Chemokine interleukin-8-like domain (domain) [31-90]
Interaction partners: - Macrophage inflammatory protein-1 alpha receptor
- C-C motif chemokine 7
- C-C chemokine receptor type 5
- C-C chemokine receptor type 3
- C-X-C chemokine receptor type 3
- C-X-C chemokine receptor type 4
- CX3C chemokine receptor 1
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine
- C-C motif chemokine 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0005126 (cytokine receptor binding), GO:0048018 (receptor ligand activity), GO:0001664 (G protein-coupled receptor binding), GO:0005125 (cytokine activity), GO:0042379 (chemokine receptor binding), GO:0008009 (chemokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0007568 (aging), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0040012 (regulation of locomotion), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0003008 (system process), GO:0048878 (chemical homeostasis), GO:0050900 (leukocyte migration), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0002262 (myeloid cell homeostasis), GO:0048522 (positive regulation of cellular process), GO:0009266 (response to temperature stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:2000145 (regulation of cell motility), GO:0043207 (response to external biotic stimulus), GO:0002685 (regulation of leukocyte migration), GO:0009410 (response to xenobiotic stimulus), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:1901343 (negative regulation of vasculature development), GO:0003013 (circulatory system process), GO:0009725 (response to hormone), GO:0009408 (response to heat), GO:0035295 (tube development), GO:0055082 (intracellular chemical homeostasis), GO:0010035 (response to inorganic substance), GO:0007611 (learning or memory), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0043270 (positive regulation of monoatomic ion transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0051049 (regulation of transport), GO:0009611 (response to wounding), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0050920 (regulation of chemotaxis), GO:0006952 (defense response), GO:0033500 (carbohydrate homeostasis), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:1901343 (negative regulation of vasculature development), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0002687 (positive regulation of leukocyte migration), GO:0098542 (defense response to other organism), GO:0009991 (response to extracellular stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009617 (response to bacterium), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0001818 (negative regulation of cytokine production), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0009612 (response to mechanical stimulus), GO:0050921 (positive regulation of chemotaxis), GO:0034599 (cellular response to oxidative stress), GO:1901652 (response to peptide), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0032642 (regulation of chemokine production), GO:0043067 (regulation of programmed cell death), GO:0001944 (vasculature development), GO:0048732 (gland development), GO:0002237 (response to molecule of bacterial origin), GO:0030334 (regulation of cell migration), GO:0010468 (regulation of gene expression), GO:2000177 (regulation of neural precursor cell proliferation), GO:0031100 (animal organ regeneration), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0031667 (response to nutrient levels), GO:0050729 (positive regulation of inflammatory response), GO:0072359 (circulatory system development), GO:0036293 (response to decreased oxygen levels), GO:0030335 (positive regulation of cell migration), GO:0007417 (central nervous system development), GO:0002688 (regulation of leukocyte chemotaxis), GO:0051252 (regulation of RNA metabolic process), GO:0071675 (regulation of mononuclear cell migration), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0010038 (response to metal ion), GO:0003018 (vascular process in circulatory system), GO:0050890 (cognition), GO:0034097 (response to cytokine), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:1905523 (positive regulation of macrophage migration), GO:1905521 (regulation of macrophage migration), GO:0071310 (cellular response to organic substance), GO:0062197 (cellular response to chemical stress), GO:0060284 (regulation of cell development), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:1901342 (regulation of vasculature development), GO:1901699 (cellular response to nitrogen compound), GO:0010628 (positive regulation of gene expression), GO:0032652 (regulation of interleukin-1 production), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0007600 (sensory perception), GO:0035150 (regulation of tube size), GO:0043434 (response to peptide hormone), GO:0060326 (cell chemotaxis), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0042060 (wound healing), GO:0006954 (inflammatory response), GO:0010243 (response to organonitrogen compound), GO:0050727 (regulation of inflammatory response), GO:0048514 (blood vessel morphogenesis), GO:0033993 (response to lipid), GO:0042593 (glucose homeostasis), GO:0008347 (glial cell migration), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045765 (regulation of angiogenesis), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0071222 (cellular response to lipopolysaccharide), GO:0045471 (response to ethanol), GO:2001141 (regulation of RNA biosynthetic process), GO:0071345 (cellular response to cytokine stimulus), GO:0032651 (regulation of interleukin-1 beta production), GO:0097746 (blood vessel diameter maintenance), GO:0050767 (regulation of neurogenesis), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0097421 (liver regeneration), GO:0090023 (positive regulation of neutrophil chemotaxis), GO:0043065 (positive regulation of apoptotic process), GO:0043279 (response to alkaloid), GO:0001938 (positive regulation of endothelial cell proliferation), GO:0071375 (cellular response to peptide hormone stimulus), GO:0070555 (response to interleukin-1), GO:0032868 (response to insulin), GO:0006355 (regulation of DNA-templated transcription), GO:0014910 (regulation of smooth muscle cell migration), GO:0034284 (response to monosaccharide), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)