Protein: Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4) (Q9WVL3)
Organism: Mus musculus (Mouse)
Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:23376777}; Multi-pass membrane protein {ECO:0000269|PubMed:23376777}.
Sequence: MPTNFTVVPVEARADGAGDEAAERTEEPESPESVDQTSPTPGDGNPRENSPFINNVEVERESYFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEDSRRREVKAPRMGTFIGVYLPCLQNILGVILFLRLTWIVGAAGVMESFLIVAMCCTCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPSAAIFQAETADGEAAALLNNMRVYGSCALALMAVVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKTAFAPPDIPVCLLGNRTLANRNFDTCAKMQVVSNGTVTTALWRLFCNGSSLGATCDEYFAQNNVTEIQGIPGVASGVFLDNLWSTYSDKGAFVEKKGVSSVPVSEESRPGGLPYVLTDIMTYFTMLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGVVLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLQVFGHGKANGEPTWALLLTALICETGILIASLDSVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALFAMLIAGCIYKYIEYRGAEKEWGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLVMLNLDSEQCVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHVEAQRAEENIRSLMSAEKTKGFCQLVVSSNLRDGASHLIQSAGLGGMKHNTVLMAWPEAWKEADNPFSWKNFVDTVRDTTAAHQALLVAKNIDLFPQNQERFSDGNIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLYHLRISAEVEVVEMVENDISAFTYEKTLMMEQRSQMLKQMQLSKNEREREAQLIHDRNTASHTTATARTQAPPTPDKVQMTWTKEKLIAEKHRNKDTGPSGFKDLFSLKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKSRQGDENYMEFLEVLTEGLNRVLLVRGGGREVITIYS
InterPro domains: - IPR000076: K/Cl co-transporter (family) [47-574]
- IPR004842: SLC12A transporter family (family) [46-1083]
- IPR004841: Amino acid permease/ SLC12A domain (domain) [124-695]
- IPR018491: SLC12A transporter, C-terminal (domain) [709-1083]
Interaction partners: - STE20/SPS1-related proline-alanine-rich protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015296 (monoatomic anion:monoatomic cation symporter activity), GO:0015293 (symporter activity), GO:0015379 (potassium:chloride symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015377 (chloride:monoatomic cation symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0035264 (multicellular organism growth), GO:0007267 (cell-cell signaling), GO:0048589 (developmental growth), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0009266 (response to temperature stimulus), GO:0050877 (nervous system process), GO:0099536 (synaptic signaling), GO:0040040 (thermosensory behavior), GO:0009410 (response to xenobiotic stimulus), GO:0007611 (learning or memory), GO:0006810 (transport), GO:0050890 (cognition), GO:0007612 (learning), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0099537 (trans-synaptic signaling), GO:0006821 (chloride transport), GO:0098916 (anterograde trans-synaptic signaling), GO:0006820 (monoatomic anion transport), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0005886 (plasma membrane)