Protein: Jouberin (H0Y343)
Organism: Homo sapiens (Human)
Function: Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development
Subcellular location: Cell junction, adherens junction. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Sequence: DVDGDGVHEITSRDSPVYPKCLLDDDLVLGVYIHRTDRLKSDFMISHPMVKIHVVDEHTGQYVKKDDSGRPVSSYYEKENVDYILPIMTQPYDFKQLKSRLPEWEEQIVFNENFPYLLRGSDESPKVILFFEILDFLSVDEIKNNSEVQNQECGFRKIAWAFLKLLGANGNANINSKLRLQLYYPPTKPRSPLSVVEAFEWWSKCPRNHYPSTLYVTVRGLKVPDCIKPSYRSMMALQEEKGKPVHCERHHESSSVDTEPGLEESKEVIKWKRLPGQACRIPNKHLFSLNAGERGCFCLDFSHNGRILAAACASRDGYPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKNEINNTNTFRVLPHPSFVYTAKFHPAVRELVVTGCYDSMIRIWKVEMREDSAILVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKINDLEHSVHHWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLRILVARKFVGAANYREKIHSTLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDLPFKSPIRDISYHPFENMVAFCAFGQNEPILLYIYDFHVAQQEAEMFKRYNGTFPLPGIHQSQDALCTCPKLPHQGSFQIDEFVHTESSSTKMQLVKQRLETVTEVIRSCAAKVNKNLSFTSPPAVSSQQSKLKQSNMLTAQEILHQFGFTQTGIISIERKPCNHQVDTAPTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHVASETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKVNVFEHTYYICTLIFTLSG
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [737-792]
- IPR001452: SH3 domain (domain) [735-795]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [288-591]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [280-603]
- IPR001680: WD40 repeat (repeat) [282-603]
- IPR052803: Primary Cilium-Associated Jouberin (family) [10-806]
- IPR035832: Jouberin, SH3 domain (domain) [739-790]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0090068 (positive regulation of cell cycle process), GO:0042127 (regulation of cell population proliferation), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0008285 (negative regulation of cell population proliferation), GO:0010564 (regulation of cell cycle process), GO:0045787 (positive regulation of cell cycle), GO:1901989 (positive regulation of cell cycle phase transition), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:1901987 (regulation of cell cycle phase transition), GO:0042981 (regulation of apoptotic process), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0043066 (negative regulation of apoptotic process), GO:1902808 (positive regulation of cell cycle G1/S phase transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)