Protein: Angiogenin-4 (EC 3.1.27.-) (Q3TMQ6)
Organism: Mus musculus (Mouse)
Function: Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro).
Subcellular location: Secreted {ECO:0000269|PubMed:12548285}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269|PubMed:12548285}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Note=Exposure to bacterial lipopolysaccharide (LPS) triggers secretion from intestinal epithelium cells (PubMed:12548285). Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity). {ECO:0000250|UniProtKB:P03950, ECO:0000269|PubMed:12548285}.
Sequence: MTMSPCPLLLVFVLGLVVIPPTLAQNERYEKFLRQHYDAKPNGRDDRYCESMMKERKLTSPCKDVNTFIHGTKKNIRAICGKKGSPYGENFRISNSPFQITTCTHSGASPRPPCGYRAFKDFRYIVIACEDGWPVHFDESFISP
InterPro domains: - IPR023412: Ribonuclease A-domain (domain) [25-141]
- IPR036816: Ribonuclease A-like domain superfamily (homologous_superfamily) [22-144]
- IPR023411: Ribonuclease A, active site (active_site) [62-68]
- IPR001427: Pancreatic ribonuclease (family) [3-141]
Interaction partners: - Angiogenin-2
- Angiogenin ribonuclease 6
- Regenerating islet-derived protein 3-gamma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0035265 (organ growth), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0003008 (system process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0044237 (cellular metabolic process), GO:0016049 (cell growth), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0055017 (cardiac muscle tissue growth), GO:0048513 (animal organ development), GO:0019538 (protein metabolic process), GO:0003014 (renal system process), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0033500 (carbohydrate homeostasis), GO:1901700 (response to oxygen-containing compound), GO:0060419 (heart growth), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0006793 (phosphorus metabolic process), GO:0003012 (muscle system process), GO:0055082 (intracellular chemical homeostasis), GO:0048588 (developmental cell growth), GO:0061061 (muscle structure development), GO:1901698 (response to nitrogen compound), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0009743 (response to carbohydrate), GO:0061049 (cell growth involved in cardiac muscle cell development), GO:0055006 (cardiac cell development), GO:0014896 (muscle hypertrophy), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0070528 (protein kinase C signaling), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0055001 (muscle cell development), GO:0003301 (physiological cardiac muscle hypertrophy), GO:1901699 (cellular response to nitrogen compound), GO:0070293 (renal absorption), GO:0036211 (protein modification process), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0043412 (macromolecule modification), GO:0010243 (response to organonitrogen compound), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:0042593 (glucose homeostasis), GO:0060537 (muscle tissue development), GO:0051247 (positive regulation of protein metabolic process), GO:0035051 (cardiocyte differentiation), GO:1901701 (cellular response to oxygen-containing compound), GO:0001678 (intracellular glucose homeostasis), GO:0010467 (gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0007507 (heart development), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0031399 (regulation of protein modification process), GO:0071375 (cellular response to peptide hormone stimulus), GO:0045937 (positive regulation of phosphate metabolic process), GO:0071322 (cellular response to carbohydrate stimulus), GO:0071333 (cellular response to glucose stimulus), GO:0006468 (protein phosphorylation), GO:0034284 (response to monosaccharide), GO:0055013 (cardiac muscle cell development), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:1901653 (cellular response to peptide), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:0003298 (physiological muscle hypertrophy), GO:0014897 (striated muscle hypertrophy), GO:1990776 (response to angiotensin), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0003300 (cardiac muscle hypertrophy), GO:0071326 (cellular response to monosaccharide stimulus), GO:1904385 (cellular response to angiotensin), GO:0042327 (positive regulation of phosphorylation), GO:0009746 (response to hexose), GO:0001934 (positive regulation of protein phosphorylation), GO:0071331 (cellular response to hexose stimulus), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)