Protein: G1/S-specific cyclin CCN1 (Q59YH3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth
Sequence: MTSLQQQRVKYGPPHHIKRRPYHPILESLEFQTNQHLIQEYSLDIVNTLSQLESLTLVNPAMIDLQPEIQWFMRPFLLDFLIELHSSFKLQPTTLFLCLNIIDRYCAKRIVFKRHYQLVGCTALWIASKYEDKKSRVPTLKELTIMCRNAYDEEMFVQMEMHILSTLDWSIGHPTLEDCLQLAIDSNNLSNNTTNDIENKSVRPNRKSSISSAVTAVARFLCELSLYDKYFLSVPPSLIAITANLLSCSMLQIPHASITLKNLIEQEIINPQQKKQKKALSSNSSRTTTASYTHQNQSDVRHSSFDEDIDLDSGDEEDDDEDYIDEFYETNNYDDTNATTFDESISKSTTVNDENQPPQIHTPFLSGLDEDSILSIKKICLMLIIQLSKVTEVLSKKYENLGVIQVINNFHSNYKFIIQSIYENQELLLNTINDSTNNNEIDYKLIQSSEILLQFPKFDEYLTEDEDENVSTDDEANSQPQGYDGSGSDGNNQLFTPKSPNAFSSNSSLTLNNHPQSMVPVTPPSATSQYSLFSNKNNRTHESTSGLNSTCNTPTHISISSFAPPQPPPGSILKPKLTSINSTNSLKIKKLTSNSNSSNINIHHGHHNTKQEKRYSHISIGSNSSSKYDGFSPIKSISTNGSLITNNGSLITNNGSFTNIVNNTNSSSPLMNQQQQQQVTQSSLYQHHHQYHQ
InterPro domains: - IPR013763: Cyclin-like domain (domain) [79-165]
- IPR014399: Cyclin CLN (family) [4-611]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [32-261]
- IPR004367: Cyclin, C-terminal domain (domain) [174-309]
- IPR039361: Cyclin (family) [38-270]
- IPR006671: Cyclin, N-terminal (domain) [44-171]
- IPR048258: Cyclins, cyclin-box (conserved_site) [74-105]
Interaction partners: - Nucleoporin NSP1
- Cyclin-dependent kinase 1
- Negative regulator of the PHO system
- Mitosis inhibitor protein kinase SWE1
- Serine/threonine-protein kinase
- Ubiquitin-protein transferase activating protein
- Cdh1p
- CDC20/Fizzy WD40 domain-containing protein
- Cyclin-dependent protein kinase-activating kinase
- Septin CDC11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0019954 (asexual reproduction), GO:0032505 (reproduction of a single-celled organism), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0045927 (positive regulation of growth), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0050790 (regulation of catalytic activity), GO:0030448 (hyphal growth), GO:0090068 (positive regulation of cell cycle process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0045787 (positive regulation of cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:1901989 (positive regulation of cell cycle phase transition), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:0051246 (regulation of protein metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0051338 (regulation of transferase activity), GO:0045931 (positive regulation of mitotic cell cycle), GO:0051174 (regulation of phosphorus metabolic process), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0043549 (regulation of kinase activity), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0031399 (regulation of protein modification process), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902808 (positive regulation of cell cycle G1/S phase transition), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0007089 (traversing start control point of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:1990234 (transferase complex), GO:0043227 (membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex), GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)