Protein: A disintegrin and metalloproteinase with thrombospondin motifs 1 (Q5W7F4)
Organism: Bombyx mori (Silk moth)
Function: Involved in larval molting and metamorphosis. May degrade extracellular matrix (ECM) and basement membrane (BM) during the development of organs to allow degeneration and remodeling of tissues
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence: MPCCLWAALSLLLAVVGAGAWTPPRQPLLLTPRHRRHAQETHHLRLLGWDLKLKENKAIRSPYYKECQFFTGRVLHEEGSAVTVTECDGQLYGLLQVGGEEFVLQPTRTQEKHVLRRRDVTHSERSAEYNLTGDTVIDLDLDFDEDDDLLPTSHVHPRHSDHSDKEYFHDMHLFRRPASGVKGLWLELAIVADNTMLKFHGRERVKHYILALMNIVSAIFNDPSLGSNITLVINKLFLYEDKDIILKYGNIKKSLEAINKWNYRHLMKLPEGSTGWDATIWLTRSQLGGPSGFAPVGGVCTKTRSAAIDRDEGLTSAFVIAHELAHLLGLTHDGEGNCQSEALRGSVMAPTVLATLHNFAWSSCSKEQFHAKSKKWWCLHERSTDEGVELGGAKELSNYVFTMDEQCRTEFGEGFSVCRSVKVRSACSRLWCAHRAMPHVCRSKRAPPLEGTPCGQNQWCVDRVCEPMPGHSKETKVENKHTPEWGDWEEWSACNADCGYGLRTRTRKCKYRGFVSESACEGAGSQVATCWAGSSCAATRDIRSDLCHRQQSRLIPYLHANESNHCEISCVDYAGGSPTNFGALPDGTPCSYLRPFDVCFQGTCVKGQCNSSDTTCNWCPDGYCNNNTNTYTRLLGNGWTRMTMVPHEARQLSIHIATPIPLHIALRERKRDKPILELSKHSKKFDISSLQDNYLKYDPSVPQNLQIVEMDSNILDLKESFRYEGEAITAGTLLRWNQTDTDIYITSESRLQTDLMIMAIPVNPTLEDAVSVDASVNYSTPTGRTRPLEYRWSIERGPCSASCGGGVRLITAQCHRDQKCPPPRYESCNTHSCEFVWASDDWEECSSTCGSNGVQERQLFCVPSNASMLSRREFIKHSVSPVMCSSSKPPHRQPCNRIPCPVYWREQPWTPCSASCGRGVSRRPLTCPASDELLCGPKPRERRRRCRLRRCPSALRVAVQCPERDHAHYCELFTLEQLHRNCEVPPFRKYCCNACRDADRRQHRRYG
InterPro domains: - IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [183-393]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [482-952]
- IPR041645: ADAMTS, cysteine-rich domain 2 (domain) [400-465]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [184-380]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [461-959]
- IPR006586: ADAM, cysteine-rich domain (domain) [402-468]
- IPR050439: ADAMTS and ADAMTS-like (family) [208-964]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009967 (positive regulation of signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:2000026 (regulation of multicellular organismal development), GO:1901564 (organonitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:1901343 (negative regulation of vasculature development), GO:0043170 (macromolecule metabolic process), GO:0006508 (proteolysis), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0051604 (protein maturation), GO:0030510 (regulation of BMP signaling pathway), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0010467 (gene expression), GO:0032925 (regulation of activin receptor signaling pathway), GO:0008610 (lipid biosynthetic process), GO:1902547 (regulation of cellular response to vascular endothelial growth factor stimulus), GO:1900746 (regulation of vascular endothelial growth factor signaling pathway), GO:0016525 (negative regulation of angiogenesis), GO:0016485 (protein processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)