Protein: Metabotropic glutamate receptor 4 (mGluR4) (Q14833)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}; Multi-pass membrane protein {ECO:0000269|PubMed:7617140, ECO:0000269|PubMed:8738157}.
Sequence: MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
InterPro domains: - IPR000337: GPCR, family 3 (family) [46-803]
- IPR000162: GPCR, family 3, metabotropic glutamate receptor (family) [248-835]
- IPR050726: Metabotropic Glutamate Receptor (family) [38-875]
- IPR011500: GPCR, family 3, nine cysteines domain (domain) [516-566]
- IPR017978: GPCR family 3, C-terminal (domain) [581-861]
- IPR017979: GPCR, family 3, conserved site (conserved_site) [165-791]
- IPR001828: Receptor, ligand binding region (domain) [78-481]
- IPR038550: GPCR, family 3, nine cysteines domain superfamily (homologous_superfamily) [514-588]
- IPR001786: GPCR, family 3, metabotropic glutamate receptor 4 (family) [9-911]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [45-510]
Interaction partners: - Metabotropic glutamate receptor 2
- Metabotropic glutamate receptor 6
- Metabotropic glutamate receptor 8
- Metabotropic glutamate receptor 1
- Guanine nucleotide-binding protein G
- Metabotropic glutamate receptor 7
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Glutamate receptor ionotropic, kainate 1
- 5-hydroxytryptamine receptor 1A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0003008 (system process), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0050877 (nervous system process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007215 (glutamate receptor signaling pathway), GO:0007216 (G protein-coupled glutamate receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0007600 (sensory perception), GO:0050953 (sensory perception of light stimulus), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0007601 (visual perception)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0023051 (regulation of signaling), GO:0003008 (system process), GO:0007154 (cell communication), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0050877 (nervous system process), GO:0099536 (synaptic signaling), GO:0099177 (regulation of trans-synaptic signaling), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007215 (glutamate receptor signaling pathway), GO:0007216 (G protein-coupled glutamate receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0007600 (sensory perception), GO:0050804 (modulation of chemical synaptic transmission), GO:0099537 (trans-synaptic signaling), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)