Protein: Uncharacterized protein YGR042W (P53227)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence: MLSHIVEYECQYTDQLYKKRKIWHDGRLKYFQLNNRFMLYTEKDNVLLASEFKINSKELKAILNPEGFDIEEHRIFSQFLVIISNIIEEYDRDIQVAATHVRAYPSNLSVQKQRPLISDNAPSLNHISTAREVHSNIKVTTPNRKQTEDNATKGGFNISKLTLKVNKPFKKPKRILSTNVVNESNRPSIRSQKIQEVTPQLHETNTSTKVQTAGKVALNNDNIAQGNYATITEEAKVRDGSDRKKDMANLSKSGKRRVGGIRRIVHEPLGI
InterPro domains: - IPR018838: 5'-3' DNA helicase ZGRF1-like, N-terminal domain (domain) [5-94]
Interaction partners: - ATP-dependent DNA helicase MPH1
- Inner kinetochore subunit MHF2
- Inner kinetochore subunit MHF1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0003688 (DNA replication origin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009892 (negative regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0051129 (negative regulation of cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0043462 (regulation of ATP-dependent activity), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0051095 (regulation of helicase activity), GO:0051053 (negative regulation of DNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0051052 (regulation of DNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0032781 (positive regulation of ATP-dependent activity), GO:2001251 (negative regulation of chromosome organization), GO:0033044 (regulation of chromosome organization), GO:0032204 (regulation of telomere maintenance), GO:0032205 (negative regulation of telomere maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0090734 (site of DNA damage), GO:0005737 (cytoplasm), GO:0035861 (site of double-strand break), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000781 (chromosome, telomeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)