Protein: Ly6/PLAUR domain-containing protein 6 (D3ZTT2)
Organism: Rattus norvegicus (Rat)
Function: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q86Y78}. Cytoplasm {ECO:0000250|UniProtKB:Q86Y78}. Cell membrane {ECO:0000269|PubMed:27344019}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:27344019}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000269|PubMed:34631692}. Perikaryon {ECO:0000269|PubMed:34631692}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000269|PubMed:34631692}.
Sequence: MEPSPALAWLLLLSLVADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRDTRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGYKICTSCCEGNICNLPLPRNDTDATFATTSPINQTNGHPHCVSVIVSCLWVWLGLTL
InterPro domains: - IPR045860: Snake toxin-like superfamily (homologous_superfamily) [44-131]
- IPR039457: Ly6/PLAUR domain-containing protein 6-like (family) [5-170]
Interaction partners: - Ly-6/neurotoxin-like protein 1
- Secreted Ly6/Plaur domain containing 1
- Lymphocyte antigen 6 family member H.
- Frizzled-8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030545 (signaling receptor regulator activity), GO:0099602 (neurotransmitter receptor regulator activity), GO:0030548 (acetylcholine receptor regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0023057 (negative regulation of signaling), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0045595 (regulation of cell differentiation), GO:0051962 (positive regulation of nervous system development), GO:0045746 (negative regulation of Notch signaling pathway), GO:0008593 (regulation of Notch signaling pathway), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0048713 (regulation of oligodendrocyte differentiation), GO:0014015 (positive regulation of gliogenesis), GO:0045687 (positive regulation of glial cell differentiation), GO:0050767 (regulation of neurogenesis), GO:0048714 (positive regulation of oligodendrocyte differentiation), GO:0014013 (regulation of gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)