Protein: Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Q811W2)
Organism: Mus musculus (Mouse)
Function: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation (By similarity). Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA (By similarity). Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA (By similarity). Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}.
Sequence: MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDTLSSLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
InterPro domains: - IPR001128: Cytochrome P450 (family) [73-466]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [38-492]
- IPR002403: Cytochrome P450, E-class, group IV (family) [71-459]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [434-443]
Interaction partners: - Retinal dehydrogenase 2
- Retinaldehyde dehydrogenase 3
- Aldehyde dehydrogenase 1A1
- Cytochrome P450 1A2
- Cytochrome P450 1A1
- Aldehyde dehydrogenase, cytosolic 1
- Cytochrome P450 3A
- Cytochrome P450 3A11
- Cytochrome P450 3A13
- Cytochrome P450 3A25
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042445 (hormone metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010171 (body morphogenesis), GO:0010648 (negative regulation of cell communication), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:0030902 (hindbrain development), GO:0006766 (vitamin metabolic process), GO:0010817 (regulation of hormone levels), GO:0009887 (animal organ morphogenesis), GO:0006629 (lipid metabolic process), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0006082 (organic acid metabolic process), GO:0097094 (craniofacial suture morphogenesis), GO:0009790 (embryo development), GO:0042573 (retinoic acid metabolic process), GO:1901575 (organic substance catabolic process), GO:1904888 (cranial skeletal system development), GO:0030278 (regulation of ossification), GO:0060323 (head morphogenesis), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0006720 (isoprenoid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0048562 (embryonic organ morphogenesis), GO:0043436 (oxoacid metabolic process), GO:0061448 (connective tissue development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0006775 (fat-soluble vitamin metabolic process), GO:0016054 (organic acid catabolic process), GO:0048568 (embryonic organ development), GO:0060348 (bone development), GO:0001501 (skeletal system development), GO:0009111 (vitamin catabolic process), GO:0060349 (bone morphogenesis), GO:0046395 (carboxylic acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0008300 (isoprenoid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0016115 (terpenoid catabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)