Protein: Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (Q20077)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00037860}.
Sequence: MKSESDVEYTIKQPDLTDVPTQSAKNLADGTIIVGENDTSDKEIEIEKEDTTKPTHDRQSWTMRLISSESFNAPMAVEYLNSIQDKPSLTFLGKRLFDLPEKDLDFYLPQLMYLYVTKVDAASVSHAYIEERNKKDAQFTVLCIWLLNCFTKNVPNKYENHALMLKSLLSRSNVPGTSQSADNMITLSLDRLEETNWTVGSSYGKSAGALARAAIQKESTLTAEHDSYEKSRCGPISTKLLTNQQNFIGRLVYIGVKLTEHHLLSSKQEKTIALQSELSMLNSMLPNSVWIPFDFENTMFNICVNESAVLNSKDKVPYVFFAEVIRSSPNYNSNIKTLSSVEPRIKKSQSESVLLKNKSYHDSTDPSIAVFAESWAEKKARIRGSSRYENHQKWDLIPVIVKTGDDLSQEAFAQQLLFTFKDLWHEEGVPLYLRPYKIVCIGSDAGLIEPVLDTLSLHQIKRHLTNVFRMNGNVTTPSLKHHFENVFGPVNSETYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLDMDGHLIHIDYGFLLSSSPRNLGFETAPFKLTTEIIDVMGGIDSDMFLYFKSLLLRGLMAARKHHRRIVSLAEIMSAGSKMQCFRAGAETVRALEARFHVSSTDEQLQQLVDTLVEGSRDSYTTRFYDSFQYYTNGIH
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [240-660]
- IPR015433: Phosphatidylinositol 3-/4-kinase (family) [359-665]
- IPR049160: PI4KB/PIK1, accessory domain (domain) [75-148]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [471-665]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [364-664]
- IPR001263: Phosphoinositide 3-kinase, accessory (PIK) domain (domain) [1-171]
- IPR057754: Phosphatidylinositol 4-kinase beta/PIK1, catalytic domain (domain) [367-666]
Interaction partners: - PIPK domain-containing protein
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Phosphatidylinositol 4-kinase type 2
- Phosphatidylinositol 4-kinase type 2
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol-3-phosphate 5-kinase
- Phosphatidylinositol-3-phosphatase SAC1
- 1-phosphatidylinositol-5-phosphate 4-kinase
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Synaptojanin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0016301 (kinase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0007163 (establishment or maintenance of cell polarity), GO:0042330 (taxis), GO:0051240 (positive regulation of multicellular organismal process), GO:0022402 (cell cycle process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0008340 (determination of adult lifespan), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051606 (detection of stimulus), GO:0007017 (microtubule-based process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009581 (detection of external stimulus), GO:0009266 (response to temperature stimulus), GO:0009968 (negative regulation of signal transduction), GO:2000145 (regulation of cell motility), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0009582 (detection of abiotic stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0032886 (regulation of microtubule-based process), GO:0010948 (negative regulation of cell cycle process), GO:0009725 (response to hormone), GO:0006914 (autophagy), GO:0006793 (phosphorus metabolic process), GO:0051726 (regulation of cell cycle), GO:0048580 (regulation of post-embryonic development), GO:0009887 (animal organ morphogenesis), GO:0140013 (meiotic nuclear division), GO:0006629 (lipid metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0010564 (regulation of cell cycle process), GO:0044260 (cellular macromolecule metabolic process), GO:0007610 (behavior), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051049 (regulation of transport), GO:1903047 (mitotic cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060341 (regulation of cellular localization), GO:0019637 (organophosphate metabolic process), GO:0006970 (response to osmotic stress), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0090598 (male anatomical structure morphogenesis), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:0045165 (cell fate commitment), GO:0098771 (inorganic ion homeostasis), GO:0051130 (positive regulation of cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0034620 (cellular response to unfolded protein), GO:0010941 (regulation of cell death), GO:0046662 (regulation of oviposition), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:0000278 (mitotic cell cycle), GO:0048581 (negative regulation of post-embryonic development), GO:0061062 (regulation of nematode larval development), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0030163 (protein catabolic process), GO:0008406 (gonad development), GO:0030334 (regulation of cell migration), GO:0010468 (regulation of gene expression), GO:1902903 (regulation of supramolecular fiber organization), GO:0009057 (macromolecule catabolic process), GO:0051983 (regulation of chromosome segregation), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0043412 (macromolecule modification), GO:0046486 (glycerolipid metabolic process), GO:0007399 (nervous system development), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0031667 (response to nutrient levels), GO:0045930 (negative regulation of mitotic cell cycle), GO:0045840 (positive regulation of mitotic nuclear division), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0061024 (membrane organization), GO:0061458 (reproductive system development), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:1903034 (regulation of response to wounding), GO:0010256 (endomembrane system organization), GO:0043068 (positive regulation of programmed cell death), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0006796 (phosphate-containing compound metabolic process), GO:0032880 (regulation of protein localization), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902115 (regulation of organelle assembly), GO:0034976 (response to endoplasmic reticulum stress), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0061064 (negative regulation of nematode larval development), GO:0044265 (cellular macromolecule catabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0051493 (regulation of cytoskeleton organization), GO:0016050 (vesicle organization), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0034620 (cellular response to unfolded protein), GO:0016310 (phosphorylation), GO:1902099 (regulation of metaphase/anaphase transition of cell cycle), GO:0007010 (cytoskeleton organization), GO:0008654 (phospholipid biosynthetic process), GO:0043549 (regulation of kinase activity), GO:0051896 (regulation of protein kinase B signaling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0040024 (dauer larval development), GO:0033044 (regulation of chromosome organization), GO:0051783 (regulation of nuclear division), GO:0033365 (protein localization to organelle), GO:0040001 (establishment of mitotic spindle localization), GO:0033045 (regulation of sister chromatid segregation), GO:0031399 (regulation of protein modification process), GO:0006998 (nuclear envelope organization), GO:0046474 (glycerophospholipid biosynthetic process), GO:0006468 (protein phosphorylation), GO:0048285 (organelle fission), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0033048 (negative regulation of mitotic sister chromatid segregation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0031984 (organelle subcompartment), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0030425 (dendrite), GO:0005634 (nucleus)