Protein: Solute carrier family 25 member 3 (P12234)
Organism: Bos taurus (Bovine)
Function: Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP. Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (By similarity). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MYSSVVHLARANPFNAPHLQLVHDGLAGPRSDPAGPPGPPRRSRNLAAAAVEEQYSCDYGSGRFFILCGLGGIISCGTTHTALVPLDLVKCRMQVDPQKYKSIFNGFSVTLKEDGFRGLAKGWAPTFIGYSLQGLCKFGFYEVFKVLYSNMLGEENAYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSSASEVLKRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGYTQ
InterPro domains: - IPR044677: Mitochondrial phosphate carrier protein SLC25A3/Pic2/Mir1-like (family) [50-351]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [66-340]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [63-340]
Interaction partners: - ATP synthase F(1) complex subunit alpha, mitochondrial
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- ATP synthase F(1) complex catalytic subunit beta, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Non-selective voltage-gated ion channel VDAC2
- Non-selective voltage-gated ion channel VDAC2
- Cytochrome c oxidase subunit 5A, mitochondrial
- Chromobox 2
- ATP synthase F(0) complex subunit C3, mitochondrial
- ATP synthase peripheral stalk subunit b, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015295 (solute:proton symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0006817 (phosphate ion transport), GO:0035435 (phosphate ion transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle)