Protein: Cell surface glycoprotein MUC18 (Gicerin) (Melanoma cell adhesion molecule) (Melanoma-associated antigen MUC18) (CD antigen CD146) (Q9EPF2)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:14755543}; Single-pass type I membrane protein {ECO:0000269|PubMed:14755543}. Perikaryon {ECO:0000269|PubMed:14755543}. Note=Detected at the surface of the cell body of motor neurons.
Sequence: MGLPRLVCAFLFAACCCCRSATGVPGEEKQPTPTPDPVEVEVGNTALLKCGPAHPSGNFSQVEWFLIHKERQIPIFRVHQGKGQSEPGEYEHRLSLHGPGATLALSQVTPHDDRMFLCKSKQPRPQDHYVQLQVYKAPEEPTIQANVLGIHVDIQELKEVATCVGRNGYPIPQVIWYKNGRPLQEEENRVHIQSSQTVESSGLYTLKSVLSARLVKEDKDAQFYCELSYRLPSGNRMKESKEVTVPVLYPAEKVWVEVEPVGLLKEGDHVKIRCLTDGNPQPHFTINKKNPSTEEMEEESTDENGLLSLEPAQKHHSGVYQCQSLDLETTVMLSSDPLELLVNYVSDVQVDPTAPEVQEGDSLTLTCKAESNQDLEFEWLRDKTGQLLGKGPILQLNNVKREAGGRYLCVASVPSVPGLNRTRRVSVGIFGSPWMAAKERKVWAQENAMLNLSCEASGHPQPTISWNINGSATEWNPDPQTVVSTLNVLVTPELLETGAECTASNSLGSNTTVIILKLVTLTTLTPDSSQTTGLSTPTVSPHSRANSTSTEKKLPQQESKGVVIVAVIVCTLVLAVLGATLYYFYKKGKLPCGRSGKQEITLPPTRKSEFVVEVKSDKLPEEMALLQGSNGDKRAPGDQGEKYIDLRH
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [34-134]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [32-518]
- IPR051116: Cell Surface Receptors and Adhesion Molecules (family) [19-632]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [29-516]
- IPR007110: Immunoglobulin-like domain (domain) [141-520]
- IPR013162: CD80-like, immunoglobulin C2-set (domain) [141-235]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [446-512]
- IPR003598: Immunoglobulin subtype 2 (domain) [41-508]
- IPR003599: Immunoglobulin domain subtype (domain) [35-516]
Interaction partners: - Thy-1 membrane glycoprotein
- Integrin beta-1
- 5'-nucleotidase
- Vascular endothelial growth factor receptor 2
- CD34 molecule
- Laminin subunit alpha-4
- Receptor-type tyrosine-protein phosphatase C
- Platelet-derived growth factor receptor beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0098631 (cell adhesion mediator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0016049 (cell growth), GO:0007155 (cell adhesion), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0098609 (cell-cell adhesion), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030425 (dendrite), GO:0030424 (axon)