Protein: Chromatin-remodeling ATPase INO80 (Q59KI4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair
Subcellular location: Nucleus
Sequence: MNISSMLSSDNNVSLKESMTTATDQQQQQQAESVDHASINGNGQTSVSAVNNVQENHLSEFHSSNQQHSSIPPVGTTVEHATTTTTTATNHQPVNSSPLKHSVDENSNPTTISSLKKDTNSIIASILPESYQFDNSYTPTIDQKYKSVFESNINVINQLDQYQQMGHHLKLMKFDEVKLNNYLINTGQFASNYIDRVVAEDISSRNNKISETNKNKELIAIDYSKPLHHNSTRGKEFKWGSTRKIHKVEHKSRRRKPAATTSTTDDSNKAVAAAANGTKDHSATAGTTASANGSDTPDRRHQRQSSKPSTPILIKPKTEPGKGSPEIQPRRSSRPKVKRKAFEDELETADKQSSTQQVKKSQESTGRDHKRVKIENKQEEQQQHQQQQQADEEDEAEAEAEAEQKPKSGALSEAAAAGMTAKEFKAFMRQYDNTYIAIWKDLSRKDGPKGSRSMQQATQGRLINLRKTALLAAREAKRWQLKNTKNQKDLTTKARRAMREMFNFWKRNERLERDLKKKHEKELLDKAKKEEEEREAKRQSRKLNFLITQTELYSHFIGKKIKTDELEGTNADDNLKSNTKEHLDKYADVDGSATHDINAVDFDNDDEEALRRMAAQNAQNALIEVQNKAKQFDNSEESFKNPDTNGEEMNFQNPTLLGDITIPQPNMLKCTLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVLAYLAETYNMWGPFLVVTPASTLHNWQQEITKFVPEFKVLPYWGNAKDRKILRKFWDRKSLRYDKDSPFHVLVTSYQLIVADIAYFQKMKWQYMILDEAQAIKSSSSSRWKSLLNLTCRNRLLLTGTPIQNSMQELWALLHFIMPSIFDSHDEFSDWFAKDIESHAQSNTSLDEQQLRRLHMILKPFMLRRIKKNVQSELGDKVEIDVYCDLTTRQKKLYQQLRSQISMSDTDLLELESNSTSSDSSLANLVMQFRKVCNHPDLFERADVNSPFSFGKFAETGSFLRETNELDVNYSTENIVQYDLPRLIYDELLTPNYNKSIRDSIYSKFSIYNPENMNATGWLQGINVSPNELKHYSQMDILSRAIEMQNKPTETEKLERINYLYEGDYIPKNKKLLITDHSTSTNSSFISNSLVFSDLVSIKEKVGEDMYLNKLEPAVTPIASAPPITVNCSSMNFTNKMNNTLFDSNIRSSLIPLSLSTELKLMKDQIPLEQYPKSNMLPMPIFDYSNIRMPSMDRFIAESGKLAKLDELLIDLKRGGHRILIYFQMTRMMQIFEEYLAYKSYKYIRLDGSTTIESRREMVQAWQTNPEIFIFMLSTRAGGLGLNLTSADTVIFYDSDWNPTIDSQAMDRAHRIGQTKQVKVFRLVTRNTIEQKILERAKEKEEIQKLVVGNM
InterPro domains: - IPR038718: SNF2-like, N-terminal domain superfamily (homologous_superfamily) [643-922]
- IPR020838: DBINO domain (domain) [432-564]
- IPR001650: Helicase, C-terminal domain-like (domain) [1237-1387]
- IPR050520: INO80/SWR1 chromatin remodeling helicase (family) [602-1050]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [668-867]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [647-1387]
- IPR000330: SNF2, N-terminal (domain) [675-974]
- IPR049730: SNF2/RAD5-like, C-terminal helicase domain (domain) [1235-1360]
Interaction partners: - Arp8p
- RuvB-like helicase 1
- RuvB-like helicase 2
- Actin-related protein 4
- HMG box domain-containing protein
- Actin-related protein 5
- Actin
- Vps72/YL1 C-terminal domain-containing protein
- Ino eighty subunit 1
- TATA-binding protein-associated factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016887 (ATP hydrolysis activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0140658 (ATP-dependent chromatin remodeler activity), GO:0140097 (catalytic activity, acting on DNA), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0006338 (chromatin remodeling), GO:0051276 (chromosome organization), GO:0065004 (protein-DNA complex assembly), GO:0051383 (kinetochore organization), GO:0051382 (kinetochore assembly), GO:0034508 (centromere complex assembly), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0070603 (SWI/SNF superfamily-type complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097346 (INO80-type complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031011 (Ino80 complex), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome)