Protein: Nuclear factor kappaB subunit p65 (RELA proto-oncogene, NF-kB subunit) (V-rel reticuloendotheliosis viral oncogene homolog A (Avian)) (Q7TQN4)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPPRRIAVPSRGPTSVPKPAPQPYAFSTSLSTINFDEFSPMVLPPGQISNQALALAPSSAPVLAQTMVPSSAMVPSLAQPPAPVPVLAPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNNTDPGVFTDLASVDNSEFQQLLNQGVAMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPATLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
InterPro domains: - IPR002909: IPT domain (domain) [193-289]
- IPR000451: NF-kappa-B/Dorsal (family) [13-442]
- IPR037059: Rel homology domain (RHD), DNA-binding domain superfamily (homologous_superfamily) [9-187]
- IPR033926: NFkappaB IPT domain (domain) [194-290]
- IPR032397: Rel homology dimerisation domain (domain) [195-291]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [18-196]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [191-304]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [191-322]
- IPR011539: Rel homology domain, DNA-binding domain (domain) [16-190]
- IPR030492: Rel homology domain, conserved site (conserved_site) [34-40]
- IPR030495: Transcription factor p65, RHD domain, N-terminal (domain) [19-187]
Interaction partners: - Transcription factor RelB
- NF-kappa-B inhibitor alpha
- NF-kappa-B inhibitor beta
- Nuclear factor NF-kappa-B p105 subunit
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a.
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Histone lysine acetyltransferase CREBBP
- REL proto-oncogene, NF-kB subunit
- NF-kappa-B inhibitor epsilon
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007568 (aging), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0001101 (response to acid chemical), GO:0045597 (positive regulation of cell differentiation), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0043207 (response to external biotic stimulus), GO:0006979 (response to oxidative stress), GO:0009410 (response to xenobiotic stimulus), GO:0009966 (regulation of signal transduction), GO:1900077 (negative regulation of cellular response to insulin stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0009725 (response to hormone), GO:0006081 (cellular aldehyde metabolic process), GO:0009991 (response to extracellular stimulus), GO:0010035 (response to inorganic substance), GO:1900076 (regulation of cellular response to insulin stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0045595 (regulation of cell differentiation), GO:0009612 (response to mechanical stimulus), GO:0051962 (positive regulation of nervous system development), GO:0002931 (response to ischemia), GO:1902074 (response to salt), GO:0046683 (response to organophosphorus), GO:1901652 (response to peptide), GO:0034097 (response to cytokine), GO:0043278 (response to morphine), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0043200 (response to amino acid), GO:1901654 (response to ketone), GO:0046626 (regulation of insulin receptor signaling pathway), GO:0033590 (response to cobalamin), GO:0071310 (cellular response to organic substance), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0048545 (response to steroid hormone), GO:0002237 (response to molecule of bacterial origin), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0033273 (response to vitamin), GO:0043434 (response to peptide hormone), GO:0051591 (response to cAMP), GO:0006117 (acetaldehyde metabolic process), GO:0010243 (response to organonitrogen compound), GO:0046627 (negative regulation of insulin receptor signaling pathway), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0014070 (response to organic cyclic compound), GO:0042542 (response to hydrogen peroxide), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0071222 (cellular response to lipopolysaccharide), GO:0043279 (response to alkaloid), GO:0014072 (response to isoquinoline alkaloid), GO:0032868 (response to insulin), GO:0071345 (cellular response to cytokine stimulus), GO:0071396 (cellular response to lipid), GO:0032570 (response to progesterone), GO:0014015 (positive regulation of gliogenesis), GO:0045687 (positive regulation of glial cell differentiation), GO:0034612 (response to tumor necrosis factor), GO:0050767 (regulation of neurogenesis), GO:0014074 (response to purine-containing compound), GO:0014013 (regulation of gliogenesis), GO:0071356 (cellular response to tumor necrosis factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)