Protein: Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17) (Q803A0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6IE81}. Chromosome {ECO:0000250|UniProtKB:Q6IE81}. Cytoplasm {ECO:0000250|UniProtKB:Q6IE81}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6IE81}. Note=Localizes to the ciliary transition zone. {ECO:0000250|UniProtKB:Q6IE81}.
Sequence: MKRSRVPSTSEDSDNGSNSTSWSQHSNSKHRKQSGKRPSEVFRTDLITAMKLHDSHQLNPEDYYELADPWRQEWEKGVQVPVSPESIPQCAVRTVAEKSTAPLFIKPKKLIRSSESSMLGYVGIQTLADGMCRYDLNEEDVAWLQITNEEFSKMGMQPLDELTMERVMEEFERRCYDNMSHAMETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGIFPKCHLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGNPEKMEPITNVSHIPSNRWALICCLCKEKTGACIQCSAKSCRVAFHVTCGLHCGLKMNTILTEADEVKFKSFCPKHSGLDWNEEEGDDDRPVKVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSERKLRVQQLEDEFYRFVAADEVAEHLQLPLEMVDILFQYWKLKRKVNFNQPLIMPKKEEEDSLARREQEVLLRRLRLFTHLRQDLERVRNLTYMVSRRERIKRTLCRVQEQIFHHHVRLLEQGRVTGVSSTRRLEEAMFYFRTTPPVPASPQPLKGHCGQNSTLSSSEKGSNSYRSSKHIEADKPAKMLMDGVPSSGDSVRSETVMSASSRRSEGRTRSGESHRKEEESERPLEDRRRKSKLWDQVSIKDKLRHAKSMEDTLSSETELDTMDDRLLLSHTNANSVATAPNMYSGSPRKTNASHQGKLVPNGTSGRHLKNWGSFRIPKRSERTSAGRQTERQEADNTADQNSSLKTFSTSPSSPQIRTRLRTGSENRRHLEESDLGQSEQGKRCHTQRLPSPMTRRYGSDVIQRGVLAS
InterPro domains: - IPR050701: Histone Modification Regulator (family) [13-734]
- IPR039546: Jade-1, PHD finger (domain) [198-243]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [187-259]
- IPR034732: Extended PHD (ePHD) domain (domain) [248-362]
- IPR019787: Zinc finger, PHD-finger (domain) [196-246]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [185-363]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [199-243]
- IPR019542: Enhancer of polycomb-like, N-terminal (domain) [6-173]
- IPR001965: Zinc finger, PHD-type (domain) [198-362]
Interaction partners: - Inhibitor of growth protein
- Chromatin modification-related protein MEAF6
- Inhibitor of growth protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)