Protein: Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (Q61831)
Organism: Mus musculus (Mouse)
Function: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock. Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17724133}. Membrane {ECO:0000269|PubMed:17724133}; Lipid-anchor {ECO:0000269|PubMed:17724133}. Nucleus {ECO:0000269|PubMed:17724133}. Mitochondrion {ECO:0000269|PubMed:17724133}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton (By similarity). Recruited to the mitochondria in the presence of SARM1. {ECO:0000250}.
Sequence: MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [52-396]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [185-197]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [62-395]
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [99-201]
- IPR000719: Protein kinase domain (domain) [64-359]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [114-373]
Interaction partners: - Dual specificity mitogen-activated protein kinase kinase 4
- Transcription factor Jun
- C-Jun-amino-terminal kinase-interacting protein 3
- Dual specificity mitogen-activated protein kinase kinase 7
- C-Jun-amino-terminal kinase-interacting protein 1
- Mitogen-activated protein kinase 9
- C-Jun-amino-terminal kinase-interacting protein 2
- Nuclear factor of activated T-cells, cytoplasmic 3
- Cellular tumor antigen p53
- Bcl-2-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004712 (protein serine/threonine/tyrosine kinase activity), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0009628 (response to abiotic stimulus), GO:0031503 (protein-containing complex localization), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0001101 (response to acid chemical), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0009414 (response to water deprivation), GO:1901564 (organonitrogen compound metabolic process), GO:0099637 (neurotransmitter receptor transport), GO:0035556 (intracellular signal transduction), GO:0019538 (protein metabolic process), GO:0006970 (response to osmotic stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0051668 (localization within membrane), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045184 (establishment of protein localization), GO:0097120 (receptor localization to synapse), GO:0006793 (phosphorus metabolic process), GO:0010035 (response to inorganic substance), GO:0104004 (cellular response to environmental stimulus), GO:0009415 (response to water), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0071214 (cellular response to abiotic stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:1902074 (response to salt), GO:0098969 (neurotransmitter receptor transport to postsynaptic membrane), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0062197 (cellular response to chemical stress), GO:0000165 (MAPK cascade), GO:0071470 (cellular response to osmotic stress), GO:0071702 (organic substance transport), GO:0006796 (phosphate-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0090150 (establishment of protein localization to membrane), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0006972 (hyperosmotic response), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0015031 (protein transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0008104 (protein localization), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0098877 (neurotransmitter receptor transport to plasma membrane), GO:0072657 (protein localization to membrane), GO:0051403 (stress-activated MAPK cascade), GO:1902414 (protein localization to cell junction), GO:2001141 (regulation of RNA biosynthetic process), GO:0006468 (protein phosphorylation), GO:1903539 (protein localization to postsynaptic membrane), GO:1990778 (protein localization to cell periphery), GO:0006355 (regulation of DNA-templated transcription), GO:0071474 (cellular hyperosmotic response), GO:0016310 (phosphorylation), GO:0099003 (vesicle-mediated transport in synapse), GO:1902679 (negative regulation of RNA biosynthetic process), GO:1903540 (establishment of protein localization to postsynaptic membrane), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0007254 (JNK cascade), GO:0035418 (protein localization to synapse), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0098685 (Schaffer collateral - CA1 synapse), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)