Protein: Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D) (Q8K1S2)
Organism: Mus musculus (Mouse)
Function: Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration (By similarity). Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell.
Subcellular location: Cell membrane {ECO:0000269|PubMed:21216843, ECO:0000269|PubMed:21673655, ECO:0000269|PubMed:26235030}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MGTGAADGSRGARRWLPWLGLFFWAAGAAAARGADGSEILPDSIPSAPGTLPHFIEEPEDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEESLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTALCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQRWSRRGIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSHSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNPAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSGTFPHGNNRGFSTIHPRNKTPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMLVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVISDERHQGGQLLEEPKLLHFKGNTFSLQVSVLDIPPFLWRIKPFTACQEVPFSRVWSSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQQDGDLDSLACALEEIGRTHTKLSNITEPQIDDADFNYSRQNGL
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [52-250]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [846-940]
- IPR037936: Netrin receptor UNC5A-D (family) [212-933]
- IPR013098: Immunoglobulin I-set (domain) [158-246]
- IPR033772: UPA domain (domain) [690-829]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [47-249]
- IPR007110: Immunoglobulin-like domain (domain) [164-242]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [250-358]
- IPR003598: Immunoglobulin subtype 2 (domain) [169-236]
- IPR042058: UNC5D, Death domain (domain) [856-953]
- IPR003599: Immunoglobulin domain subtype (domain) [163-248]
- IPR000488: Death domain (domain) [850-941]
- IPR057755: Netrin receptor UNC5A-D-like, N-terminal domain (domain) [48-150]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [249-357]
- IPR000906: ZU5 domain (domain) [543-685]
Interaction partners: - Adhesion G protein-coupled receptor L3
- Netrin-1
- Leucine-rich repeat transmembrane protein FLRT2
- Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L1
- Netrin receptor DCC
- Glypican-3
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Tyrosine-protein phosphatase non-receptor type 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0035234 (ectopic germ cell programmed cell death), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0000902 (cell morphogenesis), GO:0010941 (regulation of cell death), GO:0060322 (head development), GO:0070887 (cellular response to chemical stimulus), GO:0010623 (programmed cell death involved in cell development), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0030030 (cell projection organization), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0030334 (regulation of cell migration), GO:0048666 (neuron development), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0006915 (apoptotic process), GO:0050919 (negative chemotaxis), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007411 (axon guidance), GO:2001222 (regulation of neuron migration), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0033564 (anterior/posterior axon guidance), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)