Protein: C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (C7) (Interferon-gamma induced protein CRG-2) (Small-inducible cytokine B10) (P17515)
Organism: Mus musculus (Mouse)
Function: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02778}.
Sequence: MNPSAAVIFCLILLGLSGTQGIPLARTVRCNCIHIDDGPVRMRAIGKLEIIPASLSCPRVEIIATMKKNDEQRCLNPESKTIKNLMKAFSQKRSKRAP
InterPro domains: - IPR033899: CXC Chemokine domain (domain) [27-88]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [24-95]
- IPR001089: CXC chemokine (family) [29-86]
- IPR018048: CXC chemokine, conserved site (conserved_site) [30-76]
- IPR001811: Chemokine interleukin-8-like domain (domain) [27-89]
- IPR039809: Chemokine beta/gamma/delta (family) [7-92]
Interaction partners: - C-X-C chemokine receptor type 3
- C-X-C motif chemokine 9
- C-C chemokine receptor type 5
- C-C chemokine receptor type 2
- C-C motif chemokine 5
- C-X-C chemokine receptor type 4
- Probable C-C chemokine receptor type 3
- Stromal cell-derived factor 1
- Platelet factor 4
- Chemokine subfamily B Cys-X-Cys
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005126 (cytokine receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005125 (cytokine activity), GO:0042379 (chemokine receptor binding), GO:0008009 (chemokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0040017 (positive regulation of locomotion), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0050920 (regulation of chemotaxis), GO:0045596 (negative regulation of cell differentiation), GO:0006959 (humoral immune response), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0045595 (regulation of cell differentiation), GO:0032101 (regulation of response to external stimulus), GO:0048839 (inner ear development), GO:0050921 (positive regulation of chemotaxis), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:0098542 (defense response to other organism), GO:0019730 (antimicrobial humoral response), GO:0045662 (negative regulation of myoblast differentiation), GO:0007423 (sensory organ development), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:0002688 (regulation of leukocyte chemotaxis), GO:0071675 (regulation of mononuclear cell migration), GO:0030334 (regulation of cell migration), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0045661 (regulation of myoblast differentiation), GO:1901623 (regulation of lymphocyte chemotaxis), GO:2000401 (regulation of lymphocyte migration), GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide), GO:0043583 (ear development), GO:0140131 (positive regulation of lymphocyte chemotaxis), GO:2000403 (positive regulation of lymphocyte migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)