Protein: Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC 1.4.4.2) (Glycine cleavage system P-protein subunit 1) (Glycine decarboxylase subunit 1) (Glycine dehydrogenase (aminomethyl-transferring) subunit 1) (Q72C59)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Sequence: MPFVPHSPEDVSVMLDAIGVNTIEDLFADIPAEMRPKSFALPKGLSEMDVCSRLEALSARNRTDVVSFLGAGFYDHHIPKAVDALSSRGEFYTAYTPYQPEAAQGTLQAIFEFQTAVCRLLDMDCANASVYDGGSALFEAMMMAVRATRRRKLVIDEALSPIYRTMLASYTSNLQLELVTVPHRDGLSDMDALKASVDDTCAAVVVQNPNFFGAITDFTDLFTHARAHKALGVISVYPVMQSVLKTPGEMGADIAVADGQSIGQPLSFGGPYLGIMTCTKPLVRQIPGRIVGRTQDVDGRTGYVLTLQAREQHIRRAKATSNICSNQALCALRSLIHLTLLGPEGLVRTAELSMERARYAAERLTALPGVELLHDAPFGNEFAVRLPVSAFEVVDRLTARGYVPGFPVGRYYPGMDNVLLVACTEKHSFEQVGILAEMLGGIL
InterPro domains: - IPR023010: Probable glycine dehydrogenase (decarboxylating) subunit 1 (family) [1-443]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [79-344]
- IPR020581: Glycine cleavage system P protein (family) [47-439]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [1-443]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [68-433]
- IPR049315: Glycine cleavage system P-protein, N-terminal domain (domain) [3-435]
Interaction partners: - aminomethyltransferase
- glycine dehydrogenase
- Glycine cleavage system H protein
- 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase
- Serine hydroxymethyltransferase
- Threonine aldolase, low-specificity
- Aminotransferase, class V
- Phosphoribosylformylglycinamidine synthase I
- Glutamine synthetase, type I
- Glu/Leu/Phe/Val dehydrogenase family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016043 (cellular component organization), GO:0006520 (amino acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0006790 (sulfur compound metabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0009063 (amino acid catabolic process), GO:0043933 (protein-containing complex organization), GO:1901605 (alpha-amino acid metabolic process), GO:0022607 (cellular component assembly), GO:0019752 (carboxylic acid metabolic process), GO:0065003 (protein-containing complex assembly), GO:0065003 (protein-containing complex assembly), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:1990204 (oxidoreductase complex)