Protein: Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (P12709)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P78917}.
Sequence: MSNNSFTNFKLATELPAWSKLQKIYESQGKTLSVKQEFQKDAKRFEKLNKTFTNYDGSKILFDYSKNLVNDEIIAALIELAKEANVTGLRDAMFKGEHINSTEDRAVYHVALRNRANKPMYVDGVNVAPEVDSVLKHMKEFSEQVRSGEWKGYTGKKITDVVNIGIGGSDLGPVMVTEALKHYAGVLDVHFVSNIDGTHIAETLKVVDPETTLFLIASKTFTTAETITNANTAKNWFLSKTGNDPSHIAKHFAALSTNETEVAKFGIDTKNMFGFESWVGGRYSVWSAIGLSVALYIGYDNFEAFLKGAEAVDNHFTQTPLEDNIPLLGGLLSVWYNNFFGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKSVTRGNVFTDYSTGSILFGEPATNAQHSFFQLVHQGTKLIPSDFILAAQSHNPIENKLHQKMLASNFFAQAEALMVGKDEEQVKAEGATGGLVPHKVFSGNRPTTSILAQKITPATLGALIAYYEHVTFTEGAIWNINSFDQWGVELGKVLAKVIGKELDNSSTISTHDASTNGLINQFKEWM
InterPro domains: - IPR018189: Phosphoglucose isomerase, conserved site (conserved_site) [277-520]
- IPR001672: Phosphoglucose isomerase (PGI) (family) [8-553]
- IPR046348: SIS domain superfamily (homologous_superfamily) [13-553]
- IPR035482: Phosphoglucose isomerase, SIS domain 2 (domain) [343-526]
- IPR023096: Phosphoglucose isomerase, C-terminal (homologous_superfamily) [513-554]
- IPR035476: Phosphoglucose isomerase, SIS domain 1 (domain) [132-296]
Interaction partners: - Glucose-6-phosphate 1-dehydrogenase
- Triosephosphate isomerase
- ATP-dependent 6-phosphofructokinase subunit alpha
- Fructose-bisphosphate aldolase
- Pyruvate kinase 1
- Phosphoglycerate kinase
- Mannose-6-phosphate isomerase
- Transketolase 1
- Hexokinase-2
- Transketolase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0016861 (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006757 (ATP generation from ADP), GO:0043436 (oxoacid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0016310 (phosphorylation), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0046034 (ATP metabolic process), GO:0046031 (ADP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0006090 (pyruvate metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)