Protein: Voltage-gated hydrogen channel 1 (Q6DHQ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Sequence: MSRYLKHFTAVGDNKSAVPTWHEEDTSHHVTTLHDAPDGLEVSTGQHLGQLSFRDSLRKLYSTERFQIVVVCLVVLDAIFVLCELLIDLSIIEADHHRIAPQVFHYLSLALLTFFMVELAGKIFAYRLEFLHHKFEVFDGIVVVVSFILDIIYISKEDAFDAMGLLILLRLWRVARIINGILVSVQNRANHRVEKLKEINESLVHQVNELKEQNTKMDQENVRLRALLKDHSIDF
InterPro domains: - IPR005821: Ion transport domain (domain) [66-181]
- IPR031846: Voltage-gated hydrogen channel 1 (family) [1-234]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [56-183]
Interaction partners: - Transmembrane phosphatase with tensin homology
- Potassium voltage-gated channel subfamily A member 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046872 (metal ion binding), GO:0005261 (monoatomic cation channel activity), GO:0015078 (proton transmembrane transporter activity), GO:0022839 (monoatomic ion gated channel activity), GO:0046914 (transition metal ion binding), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0015252 (proton channel activity), GO:0008270 (zinc ion binding), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0010035 (response to inorganic substance), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0010043 (response to zinc ion), GO:0006812 (monoatomic cation transport), GO:1902600 (proton transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)