wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Ubiquitin carboxyl-terminal hydrolase (Q1MT86)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MTEVSEILMSVLSAIRVPRPGDRVHKDECAFSFSSPESEGGLYVCMNSFLGFGSKYVDRHHAKTGQRAYLHITRTRKTQKEDDPNSGSGDPPKKKPTRLAIGIEGGFDVEQEQYEEEVKVVLFPDRQEVTLDDLSSMPDVVRERVSLSVAELQAADSVSHTLQVQQWDGEVRQESKHAAELKQLDNGLKIPPSGWKCEVCELQENLWMNLTDGKVLCGRRYFDGSGGNNHALLYYQQTGYPLAVKLGTITPDGADVYSYDEDDMVLDSKLPEHLSHFGIDMMTMEKTERTMTELEIAVNQRVGEWEVIQESGTTLRPLWGPGLTGMKNLGNSCYLNSVMQVLFTIPDFQTKYVSNIDKIFDEAPSDPTQDFKTQVAKLGYGLLSGEYSKPAPDPADEPNTSAEPRGDQVGIAPRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNCRSGMNPSEAFRFLVEEKIVCQQSQKAKYTQRVDYIVQLPVPMDQATNMDELQEAERRREEAESSGAPPPVAPRAQIPFAACLAALSEPETLTDFWSSAVQAKTTATKTTRFASFPDHLVIQIKKFTFGLDWVPKKLDVSIDVPETLDLNALRAMGQQPGEELLPEVAPPPLMTPDVEVKGILGSHGNEEDDSLYSPLLSPVLDDSTVSQLCEMGFPLEACRKAVYYTGNTGIDAAMNWVMGHMDDPDFAAPLVLPGSSSAPGTTPTESLPEEHLATIVSMGFSRDQATRALRATNNVLERAVDWIFSHLDDLESMDVSEGGRSEGGSEASREPPPGPRVRDGTGKYELFAFISHMGSSTMCGHYVCHIKKDQQWVIFNDQKVCASEKPPKDLGYLYFYRRVVE
InterPro domains: - IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [324-851]
- IPR015940: Ubiquitin-associated domain (domain) [651-758]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [325-814]
- IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [179-851]
- IPR016652: Ubiquitinyl hydrolase (family) [15-851]
- IPR001607: Zinc finger, UBP-type (domain) [173-281]
- IPR009060: UBA-like superfamily (homologous_superfamily) [704-763]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [320-851]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [324-848]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [2-268]
- IPR041432: Ubiquitinyl hydrolase, variant UBP zinc finger (domain) [15-77]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:1990380 (K48-linked deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:1904888 (cranial skeletal system development), GO:0003002 (regionalization), GO:0009953 (dorsal/ventral pattern formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: G protein-coupled receptor 186 (Q1LVV2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MDQNSSEVGLEVILAMNQLLDLPPSQMPPKPLEASVMTPWDITLCVSGVLICCENAIVVATIFSSSSLRAPMFLLIGSLAWADFLAGVGLLLHFLSRRCVYSEALELGSVGLLVSALSASVFSLLGITLDRFLSLHHALTYGSQRTHTQTRCALAVGWTLAGLQGALPALGWNCLHDGDSCSVLRPLTRVHLATLCGGFLLTLALLLQLNARICRVVLRHSHQIALQRHTLPSARTHTRRRVHTLALILATFASCWIPFALYGLLGDGSSPALYTYATLVPVTGNSLLNPLIYAYRNTHIQRVLRQTVCCCLPNTPNKNTHTPSDV
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [54-293]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [39-305]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [54-301]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0006525 (arginine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Homeobox protein Hox11 (Q8JI13)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MDHMGAHLHQTHADTISFGIDQILNNADQGSCMITNPRMQDLDYGLGCIVSTAYNTMTGNYNVNNSSGYNGNSCSVGSYNMNLGANVNGNCLNSSGVIRVPAHRPLGSVHSSIPTSAATVPSMGSMGTINNLTGLTFPWMESNRRYTKDRFTVALSPFTVTRRIGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILMQLQQEAFQKTINQPVTPDPICLHNSSLFALQNLQPWTENTAKISSVPNTD
InterPro domains: - IPR017970: Homeobox, conserved site (conserved_site) [209-232]
- IPR020479: Homeodomain, metazoa (domain) [198-232]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [161-234]
- IPR001356: Homeodomain (domain) [174-238]
- IPR042247: T-cell leukemia homeobox protein 1/2/3 (family) [8-297]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0048513 (animal organ development), GO:0048839 (inner ear development), GO:0007423 (sensory organ development), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)
Protein: Ankyrin repeat domain 33Ab (E7F2T9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MAAVQSSGFEDPHLGSCPDGDEISLLDEDTDSGSLLSEDSVLPEYELEDGKKGTANTLYEACVQNDPEALKRILERGVTCDEVMEVDINGWNGLMVAAYKGFLQIVYELHGCPHLNINHQDNDGNTALMIAAQAGHVSICNYIMNYFPGADTEIRDNRGFTALIKAAIQGRNDVVAALIMHGADVNAVDSNRGKCARDWALKTGRFDTLKRLRHLALHPTAEQFCDTYVPEWPNLKVLVSKATANRSAGQKLTHHLKNRFGFSFPRDPVENGVMDHMVRMTTSLHSPLIATATRPLCPSSPPQMGKRRLAVAELMQKHSEKLLEESSLCHRNSSISSVSPSFHSAEFVSMTCCPDTERRGSVLSIGMRTFIPRSVASRRNSIFPSGCIPQIKVTKSSEPTPKKEKKNKKDKGYLEPPKWKYKEAKEEKKKEKKALKEKEKEEKDKEKKSKDKEKRKKNKYTD
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [41-263]
- IPR002110: Ankyrin repeat (repeat) [53-190]
Interaction partners: - Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
- WD repeat domain 17
- Coiled-coil domain-containing 126
- G protein-activated inward rectifier potassium channel 3
- Si:ch211-235e9.8
- Grifin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:2000736 (regulation of stem cell differentiation), GO:1902036 (regulation of hematopoietic stem cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein Wnt (B6V3E2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for members of the frizzled family of seven transmembrane receptors
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence: MCTGLPRTACPLRLIALCILLSHAAAYFGLTGREPLVFLPGPFANEPTNGKAHLKQCEQMTLTRRQKRLCRREPGLAETLRESVRLSLLECRYQFRNERWNCSMDGRGSLLKRGFKETAFLLAVSSAALSHALAKACSSGRMERCTCDDSPGLQHREAWQWGVCGDNLKYSTKFLKKFLGQKRVSKDLRAQIDAHNINVGIRAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFQDTGHLLKYRYDTAVRVHSVTNSATGETELAGPRRHSITLPRPRPTELVFLEESPSFCRPSRYSPGTAGRPCSKDTSCSSLCCGRGYNTALRLTTLSCHCQVRWCCHVECQTCLREEEVYTCKKH
InterPro domains: - IPR043158: Wnt, C-terminal domain (homologous_superfamily) [300-356]
- IPR005817: Wnt (family) [56-356]
- IPR018161: Wnt protein, conserved site (conserved_site) [212-221]
Interaction partners: - Low density lipoprotein receptor-related protein 5
- Frizzled class receptor 7a
- Frizzled-4
- Frizzled class receptor 1
- Frizzled-5
- Frizzled 8a protein
- Secreted frizzled-related protein 1
- Frizzled class receptor 10
- Homeobox protein six1a
- Frizzled-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0035295 (tube development), GO:0021549 (cerebellum development), GO:0021575 (hindbrain morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030917 (midbrain-hindbrain boundary development), GO:0030902 (hindbrain development), GO:0009790 (embryo development), GO:0021587 (cerebellum morphogenesis), GO:0022037 (metencephalon development), GO:0007420 (brain development), GO:0035282 (segmentation), GO:0007399 (nervous system development), GO:0021915 (neural tube development), GO:0021591 (ventricular system development), GO:0007417 (central nervous system development), GO:0021532 (neural tube patterning), GO:0060429 (epithelium development), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0021903 (rostrocaudal neural tube patterning)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Superoxide dismutase [Cu-Zn] (E9QIM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Sequence: MIRFNILPLLAFLLSCHVLFCGSGSGLAYASNSDSLQAVCRMQPNTRLEPGMPRVYGHILFRQSGPKEKLSVTFRLYGLPADSQQPRAMHIHEYGDLSRGCDSTGGHYNPLNVNHPQHPGDFGNFVPVNKKIRQSLESPATLFGKLSIVGRSVVIHEGKDDLGRGGNVGSLLNGNAGGRLACCVIGLRNPQN
InterPro domains: - IPR024134: Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone (family) [32-188]
- IPR036423: Superoxide dismutase-like, copper/zinc binding domain superfamily (homologous_superfamily) [34-192]
- IPR018152: Superoxide dismutase, copper/zinc, binding site (binding_site) [88-185]
- IPR001424: Superoxide dismutase, copper/zinc binding domain (domain) [46-186]
Interaction partners: - Parkinson disease protein 7 homolog
- Catalase
- Superoxide dismutase
- Copper chaperone for superoxide dismutase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004784 (superoxide dismutase activity), GO:0016491 (oxidoreductase activity), GO:0016721 (oxidoreductase activity, acting on superoxide radicals as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009314 (response to radiation), GO:0009416 (response to light stimulus), GO:0009411 (response to UV)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Alpha-aminoadipic semialdehyde dehydrogenase (Q803R9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism
Subcellular location: Cytoplasm, cytosol. Mitochondrion. Nucleus
Sequence: MSTLLINQPEYNWLKELGLKEDNDGVYNGSWGGQGEVVTSYCPANNEPIARVRQATIAEYEETIQKALDAWKVWADVPAPKRGEIVRQIGEALRRKIKALGSLMSLEMGKVYVEGVGEVQEYVDVCDYAVGLSRMIGGPILPSERPGHVLIEQWNPVGLVGIITAFNFPVAVYGWNNAIALICGNACLWKGAPTTPLTSVAVTKIVAEVLEQNHLPGAICSMTCGGADIGMAMAKDERVGLLSFTGSTHVGKQVAMMVQERFGRQLLELGGNNAIIVFEDADLSLVVPSAVFASVGTAGQRCTTTRRLMLHESIHDEVVERIAKAYKQIRIGDPWDPNTLYGPLHTKQAVQQYLAAIEQAKQQGGTLVCGGKIMDRPGNYVEPTIITGLPHNASIVHTETFVPILYVLKFKTEEEAFSWNNEVKQGLSSSIFTKDMGRVFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTINYSKDLPLAQGIKFE
InterPro domains: - IPR044638: Aldehyde dehydrogenase family 7 member A1-like (family) [5-510]
- IPR029510: Aldehyde dehydrogenase, glutamic acid active site (conserved_site) [267-274]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [35-489]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [24-499]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [271-463]
- IPR015590: Aldehyde dehydrogenase domain (domain) [36-492]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048736 (appendage development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0033333 (fin development), GO:0060173 (limb development), GO:0051216 (cartilage development), GO:0001501 (skeletal system development), GO:0048880 (sensory system development), GO:0061448 (connective tissue development), GO:0007423 (sensory organ development), GO:0033339 (pectoral fin development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Isotocin receptor-like 1 (E4W698)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MESLLKDVILWPINDSWANSSRGNDSRGLNQTVNPLKRNEEVAKVEVTVLVLILLLALAGNLCVLVAIQTSKHGQSRMYYFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLVLMSIDRCLAIWQPLRSLRRRKDRFYVLASWIISLLFSLPQVYIFSLREVGDGVFDCWGDFVQPWGAKAYVTWISLTIYIIPVAILSVCYGLISYKIWQNFRLKTRRDQCLSLTPRPTKGAALSRVSSVKLISKAKIRTVKMTFVIVMAYIICWTPFFFVQMWSAWDPMAPREAMAFIIAMLLASLNSCCNPWIYMFFAGHLFRDLMQRCLTVSHCGCKRHWRNKNHSGTGAMRSSSSQKSVTQSSTT
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-329]
- IPR001817: Vasopressin receptor (family) [38-324]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [45-341]
- IPR002062: Oxytocin receptor (family) [28-353]
Interaction partners: - Isotocin receptor-like 2
- Guanine nucleotide-binding protein subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0009887 (animal organ morphogenesis), GO:0021536 (diencephalon development), GO:0060322 (head development), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0048853 (forebrain morphogenesis), GO:0035270 (endocrine system development), GO:0007420 (brain development), GO:0021983 (pituitary gland development), GO:0007399 (nervous system development), GO:1901342 (regulation of vasculature development), GO:0048732 (gland development), GO:0045766 (positive regulation of angiogenesis), GO:0007417 (central nervous system development), GO:0048854 (brain morphogenesis), GO:0045765 (regulation of angiogenesis), GO:0022612 (gland morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Heterogeneous nuclear ribonucleoprotein D (A0A8M9QC46)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
Sequence: MSEEQFLGEDPTMKMEENDDGEGFGEEQMSGDNGGQGEAEGSKIDASKNEEDEGKMFVGGLSWDTTKKDLKDYFTKFGEVVDCTLKLDPLTGRSRGFGFVLFKEAESVEKVITQKEHKLNGKVIDPKKAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFDAYGEVESIELPMENKTNKRRGFCFITFKEEEPVKKIMEKKYHNIGLSKCEVKVAMSKEQYQQQQQWGGRGGYTSRGRGRGGPNQNWNQGYGNYWNQGYGNYGNYGYNNQGYGGYGGYDYSGYNNYYGYDQQSGYGKSQRRGGHQNSYKPY
InterPro domains: - IPR000504: RNA recognition motif domain (domain) [54-218]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [51-243]
- IPR012956: CARG-binding factor, N-terminal (domain) [1-54]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [46-249]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0035295 (tube development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0055123 (digestive system development), GO:0048565 (digestive tract development), GO:0061008 (hepaticobiliary system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Calcium homeostasis modulator 1 (E7F2J4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MDKFRIMVQFLQANQESFMNGICGIMALASAQMYSSFEFTCPCLPDYNYAYGIGILIVPPIWFFLLGYVMNNNISVLTEEWKRPVGKRSKDPAVLRYMFSSMTQRALIAPAVWIAVTLMDGKSFLCAFSPTADLSEFVNESYQSLSQKELLKIQAKIPCKDIFEEHEIISREAATRYIRCLSQACGWTFLMVITLVAFLVRAIRPCFTQAAFLKTKYWSHYIDTERKLFDETCKEHAKSFAKVCIQQYFESISGEIVSQLPQSPAKKGKGNKDEDGEKQKSDEERLLGIRKEGDMNKVLWNWHTCKPPLLLSKRTEEMNGHAHLDTHSLTDERHTKKKAVVYYSKV
InterPro domains: - IPR029569: Calcium homeostasis modulator family (family) [1-310]
Interaction partners: - Pannexin
- R3H domain containing-like precursor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0044085 (cellular component biogenesis), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0043933 (protein-containing complex organization), GO:0071705 (nitrogen compound transport), GO:0007600 (sensory perception), GO:0022607 (cellular component assembly), GO:0015931 (nucleobase-containing compound transport), GO:0065003 (protein-containing complex assembly), GO:0007606 (sensory perception of chemical stimulus), GO:0015748 (organophosphate ester transport), GO:1901264 (carbohydrate derivative transport), GO:0015711 (organic anion transport), GO:0015867 (ATP transport), GO:0006862 (nucleotide transport), GO:0050909 (sensory perception of taste), GO:0051259 (protein complex oligomerization), GO:0015868 (purine ribonucleotide transport), GO:0015865 (purine nucleotide transport), GO:0051291 (protein heterooligomerization), GO:0051503 (adenine nucleotide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)