Protein: Spink5 protein (Q5K5D4)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MKTATVPMLLTLAFYLTQDAAGEKGNQDPCMKFQAQMKNGTLTCPKGNNSSQSLNDIIFQSECILCKRALEQGAPTKIMNVKVLSRANRATDPAKLNCESFKQRRKDGDFICPSDTSSVCGTDGKTYRGRCELCAENAKSQNHVDVKSEGECGSSHLETDMCSDFRANVQDGRLGCTRESDPILGPDGRTHGNRCAMCAELFLKEAKENATRNRESRIRRDAEKELCKEFENQVRNGRLFCTRESDPIRGPDGKMHGNKCALCAEIFMRQFTEEKGKAEKNQKDAEERAKAKMEIQKRCSEFQDRARNGTLFCTRENDPIRGLDGKTHGNLCSMCQAFFKTEAEEKKAEAGSRNRRGSEESETYAKLCDEYRKARKNGQLYCTRENAPIRGPDGKIHGNTCSMCQAFFIQEDKARAKVKREAAKEMCSEFRNQARNGMLMCTRENDPVVGPDGKRHSNKCAMCASVFLLEEEEKKKDDKTEKVDAGKAKKEAVQELCRKYHTQLRNGPLRCTRRNNPIEGLDGKMYKNACFMCWAFFQQEAKKSGAGFRPKVKREVKVDCSEYLALSKRGEIFCTRENDPVRGPDGKTHGNKCAMCKAVFKKENEERKRKEGENQRITSGESSSGGNPKAKDECAQYRESMKHGQLSCTRESDPVRGVDGEHYNNKCVMCKELLQKEMEETNKNSASRSNGTGSATGKDVCDQFRSQMKNGKLLCTRESDPTRGPDGAMHGNKCAMCKERLEKEAAEKKKKEDEEKRNTETNKSDKEDKCHEYRSMQLDGRLICTRENDPVRDADGKMHVNKCAMCQMMFEREANERKMREENSRSQPTNEAKDQCGEVHNSVEDAKPRPARSSLPSIRGISKDECSEFQNLMKNEKLTCPETDDPVRGADGTFYQNKCHMCRDVLKNEAMKRSGLQEKSSDIRSTKEGDPEFSSSSRDSDMCKNYRILPRMGYLCPKNLNPVCGDDGQTYSNPCMLCHENLMRQTNTRIHNPGACEESSNLKTVSTGTPASEKMMQ
InterPro domains: - IPR002350: Kazal domain (domain) [92-998]
- IPR050159: Kazal-type Serine Protease Inhibitor (family) [87-152]
- IPR036058: Kazal domain superfamily (homologous_superfamily) [26-997]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0004857 (enzyme inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0030414 (peptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0009892 (negative regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0065009 (regulation of molecular function), GO:0048585 (negative regulation of response to stimulus), GO:0050777 (negative regulation of immune response), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0080134 (regulation of response to stress), GO:0044092 (negative regulation of molecular function), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0031348 (negative regulation of defense response), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002701 (negative regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0002698 (negative regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0043086 (negative regulation of catalytic activity), GO:0002784 (regulation of antimicrobial peptide production), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0002921 (negative regulation of humoral immune response), GO:0051248 (negative regulation of protein metabolic process), GO:1900424 (regulation of defense response to bacterium), GO:0010468 (regulation of gene expression), GO:0002759 (regulation of antimicrobial humoral response), GO:1900425 (negative regulation of defense response to bacterium), GO:0002920 (regulation of humoral immune response), GO:0008348 (negative regulation of antimicrobial humoral response), GO:0010629 (negative regulation of gene expression), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0002786 (regulation of antibacterial peptide production), GO:0052547 (regulation of peptidase activity), GO:0045861 (negative regulation of proteolysis), GO:1902571 (regulation of serine-type peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:1900003 (regulation of serine-type endopeptidase activity), GO:0010951 (negative regulation of endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)