Protein: Cardiolipin synthase (CMP-forming) (CLS) (EC 2.7.8.41) (Q5U2V5)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UJA2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UJA2}.
Sequence: MLAWRVARGAWGSLRVAVRPPGARLGRGGSRRALLPPAACCLGCLAERWRLRPAAFALRLPGTSPRTHCSGAGKAAPEPAAGGDAAAQAPSARWVRASATSSYENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWANQKSALGSALDPLADKVLISILYISLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLPTPRTLAKYFNPCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCCTAFTTAASAYSYYHYGRKTVQVIKGK
InterPro domains: - IPR050324: CDP-alcohol phosphatidyltransferase class-I (family) [91-294]
- IPR000462: CDP-alcohol phosphatidyltransferase (family) [107-279]
- IPR043130: CDP-alcohol phosphatidyltransferase, transmembrane domain (homologous_superfamily) [96-299]
Interaction partners: - Phosphatidate cytidylyltransferase 2
- Tafazzin family protein
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- Phosphatidate cytidylyltransferase 1
- Lysocardiolipin acyltransferase 1
- Lysophosphatidylcholine acyltransferase 2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Lysophosphatidylcholine acyltransferase 1
- Lysophosphatidylglycerol acyltransferase 1
- Lysophosphatidylcholine acyltransferase 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016780 (phosphotransferase activity, for other substituted phosphate groups), GO:0008374 (O-acyltransferase activity), GO:0071617 (lysophospholipid acyltransferase activity), GO:0016411 (acylglycerol O-acyltransferase activity), GO:0042171 (lysophosphatidic acid acyltransferase activity), GO:0003841 (1-acylglycerol-3-phosphate O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006793 (phosphorus metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0046471 (phosphatidylglycerol metabolic process), GO:0006655 (phosphatidylglycerol biosynthetic process), GO:0032049 (cardiolipin biosynthetic process), GO:0032048 (cardiolipin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)