Protein: Tonsoku-like protein (D7EJH4)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Nucleus
Sequence: MDEQKLLKRRNKALRENNEGVLISVCTDLANLYVDKGRFDFAIEEYTTVANIYKKQNKQLEYAVVSRGIGEAYLGLQKFDKALKLQKIYLDIARELKNKLEEQRALATIGHTYLTTYLDSPEPDKNNLNLANKFFMKSLVVSQSLVGEASKLEIADMCARLYCNLGLVQDSLGNYDKALELFTKSINQCKAHDLYEQLQRGYMSLSSLLVKKGDSKAALQQCNLAAETAKKLRNKAVLLAGIFLSKSEILLKLGDLHGAKNALHKAYKLNTPDVKERKTIENNLKVVASMCYNQDKLLVTDSTDYPTLKKLYEKMGDGACHLKLYTKALDYYKKMMETAEKAEMTGPDLASCYYSLAETYKDNGQFEEAVEYFEKELVLCKNLKDSLNTLSNIADTKEAANEPISEVRAVYSRAIESCQREGNVHEEGRMLKRQILYLRRQKQHSEAFNLEQSLAKLDFHSSDSEGESSDAQTESVVGAEIDLEAITDVSDDSDVDQPTTHRRRSKNFQIKRNLKGETQLHTACIKGQLNVVRHLLDQGHPVNVRDNCGWLPLHEACIHGHLDVVQLLLDKGAAINDRGGTQCEGITPLHDAASNGHLPIVELLLTRGANAVAKTDEGETVLNFLRKWRTGVQLNNDSQVLYERLVEQISLALQKSGQAVIVNDDRETQRRSAIVEDSSNPDHRSDMETEAPSTSSLRRSAIIGLEDDDSSSPDRQADDYRNVMESLRRKNVKSPPKASSSVVKRPALLFDDDIVDDWLDDDLGQRSKKRKTASPVKSAPSQNCQYYQPPSRSPAKRPKQAKLTHFGHTRTLVEADSTSSPKAPEPAPKLPRPRSFDLGTDPTLSVDVRIEKKLYRVPVLLSQVATHTIKWLADEAAARYAKKQYIVPTLELETKNGAVLADDDPISLLFPMGGTQAEEVEARIVKSNLPPLIDRYKEACQDMGAVPRDSIGQVLQEFSVGLDLANRGFKGAVLAPLVKVLNRQSNLLELDLSGNFLTNECFDLLAKSLACLESLYKLNLNCTSLTSGHVQAIVANLNPDVSYKIIDLDFSDNWLRDESFESLALLTRRLQLKKFNLSNNKFTQNLFNHRLNKDLTLNLDQIEEFDISDNAFDNTTLITILSWLQFANLTHLNVSRNSLSDNFLHEVLNRMWTQTGPLRVCKLSNCHVTDSEVFDLLRVATSLQHLDVSYNDALTSISLRRLLQSGIITLDIYACGNIFQYFTEFSKYLDDASRDQNQGKTLKLSPPENSQRETEYLIEMWRELYGEKTVVELTSKFLGLSVLKV
InterPro domains: - IPR019734: Tetratricopeptide repeat (repeat) [23-383]
- IPR002110: Ankyrin repeat (repeat) [512-616]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [3-476]
- IPR052311: MMS22L-TONSL complex component (family) [1-699]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [499-648]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [950-1262]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0045005 (DNA-templated DNA replication maintenance of fidelity), GO:0006260 (DNA replication), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0006261 (DNA-templated DNA replication), GO:0000725 (recombinational repair), GO:0031297 (replication fork processing), GO:0006302 (double-strand break repair), GO:0000724 (double-strand break repair via homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)