Protein: Coiled-coil domain-containing protein 34 (Q96HJ3)
Organism: Homo sapiens (Human)
Function: Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella
Subcellular location: Cell projection, cilium, flagellum. Note=Mainly located in the mid-piece of sperm flagella
Sequence: MWAAGRWGPTFPSSYAGFSADCRPRSRPSSDSCSVPMTGARGQGLEVVRSPSPPLPLSCSNSTRSLLSPLGHQSFQFDEDDGDGEDEEDVDDEEDVDEDAHDSEAKVASLRGMELQGCASTQVESENNQEEQKQVRLPESRLTPWEVWFIGKEKEERDRLQLKALEELNQQLEKRKEMEEREKRKIIAEEKHKEWVQKKNEQKRKEREQKINKEMEEKAAKELEKEYLQEKAKEKYQEWLKKKNAEECERKKKEKEKEKQQQAEIQEKKEIAEKKFQEWLENAKHKPRPAAKSYGYANGKLTGFYSGNSYPEPAFYNPIPWKPIHMPPPKEAKDLSGRKSKRPVISQPHKSSSLVIHKARSNLCLGTLCRIQR
InterPro domains: - IPR025259: Coiled-coil domain-containing protein 34/181 (domain) [142-321]
- IPR045323: Coiled-coil domain-containing protein 34 (family) [2-352]
Interaction partners: - Rab-like protein 2A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0050794 (regulation of cellular process), GO:0051302 (regulation of cell division), GO:0051726 (regulation of cell cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0044087 (regulation of cellular component biogenesis), GO:0031109 (microtubule polymerization or depolymerization), GO:0033043 (regulation of organelle organization), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0043254 (regulation of protein-containing complex assembly), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007010 (cytoskeleton organization), GO:0051493 (regulation of cytoskeleton organization), GO:0046785 (microtubule polymerization), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0051233 (spindle midzone), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0005881 (cytoplasmic microtubule), GO:0005818 (aster), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0000235 (astral microtubule), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005819 (spindle), GO:0005874 (microtubule), GO:0005876 (spindle microtubule), GO:0072686 (mitotic spindle), GO:0015630 (microtubule cytoskeleton)