Protein: Slit homolog 3 (Drosophila) (Slit homolog 3 protein precursor) (F1RCV3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MMRWVKYWGTVAVLCGLLSCAVNGCPHKCSCSGSHVDCQGQAFKTVPRGIPRNAERLDLDRNNITRITKVDFSGLKNLRVLHLENNQISVIERGAFEGLKQLERIRLNRNRLQVLPELLFQSTTKLSRLDLSENQIQAVPRKAFRGITTVKNLQLDSNHISCIEDGAFRALRDLEILTLNNNNITLIPLSSFNHMPKLRTLRLHSNNLHCDCHLSWLSDWLRQRRGLAPFTQCMAPAHMRGLNVPDVQKREFVCTGPVETEPRSCAPQVTICPAACTCNNNIVDCRRKGLTEIPANLPEGIVEIRLEQNMIKNIPAGAFSTYKKLKRIDLSKNQISEIAEDAFSGLRSLTSLVLYGNKIAEIPKGLFDGLVSLQLLLLNANKINCLRVNTFKDLQNLNLLSLYDNKLQTISKGLFAPLRAIKTLHLAQNPFMCDCHLKWLADYLFDNPIETSGARCSHPRRLANKRISQVKGKKFRCTGAEDYRSRLSGECFQDLVCPERCRCEGTVVDCSNLKLTKIPPHLPEHTTDLRLNDNEISILEATGAFKKLPNLRKINLSNNKLRDIREGAFDGAGGVLELLLTGNKLQSVSGRMFKGLIGLKTLMLRSNQISCVDNATFTGLSSVRLLSLYDNRISTIAPGAFNTLHSLSTINLLSNPYVCDCHLAWLGLWLKKTRVVSGNPRCQKPAFLKEIPIQDVAMPDFSCDGAEENVCLPSAPRCPESCTCSETVVRCSNRGLRSLPKTIPKDTTELYLEGNLLTSVPKELPNLKQLTLLDLSNNSISHLAPLTFSNMTQLATLILSYNQIRCVPVHAFDGLRSLRLLTLHGNDLSTVPEGAFNHLTSLSHLALGANPLYCDCELRWLSQWVKAGFKEPGIARCTGPPDMADRLLLTTPLNRFQCKGPADLNLMSKCAPCLATPCQNNGTCVSDVTGSYHCTCPFGYKGRNCEIPINACISLPCTNGGTCHLTPGLDGQYSCVCPPGYEGQQCELNPDDCEDNDCENNSTCVDGINNYTCVCPPNYKGDLCEEVVDPCLPGFDLCQHDSKCVPLSKGYRCECLPGYVGQQCEQDYNDCLENKCQHGAECVDAINGYTCVCKEGFSGLFCENHPPMVLLQNTSPCDQSDCQNGSECLVMEGEPVCRCLPGYFGTKCQKMVTLHFLGKEAYVELSGTRIRPPMHISFQVATDKDNGILLYKEDHDPLALELYQGHIRLIYDISKYPPTTVYSVESVNDGLFHTVEVLIQNQTLSLVVDKGTPKSLGKLPRPPAVDHNTQLYIGGVPSLIGTSGLRPGPFQSFNGCLHDVRLNGELQDLGAGLAGIEGVLFGCHSCSVCDQGACRQRGDEGVTCDCPTGHSGPLCEQMSSQDPCESSRCVHGECVAKGSSYSCLCVDGYSGQFCDRQDESSACKGLHCVYGECRLTESGEPACHCQPGYSGPTCETELTCEGEAVRDYLYRQMAHKICTSTSRVQRLECRHSCSSGLCCAPTKSRRRKLSFKCPDGSSFSEEMEITVECGCTKCSS
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [21-902]
- IPR006207: Cystine knot, C-terminal (domain) [1440-1515]
- IPR001881: EGF-like calcium-binding domain (domain) [913-1395]
- IPR001791: Laminin G domain (domain) [1152-1323]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [982-1091]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [1136-1323]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [1004-1093]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [24-749]
- IPR013032: EGF-like, conserved site (conserved_site) [1122-1389]
- IPR051355: Notch and Slit guidance protein (family) [250-1031]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [50-838]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [206-899]
- IPR001611: Leucine-rich repeat (repeat) [53-852]
- IPR000742: EGF-like domain (domain) [911-1435]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [992-1104]
Interaction partners: - Roundabout, axon guidance receptor, homolog 1
- Roundabout, axon guidance receptor, homolog 2
- Roundabout, axon guidance receptor, homolog 2
- Roundabout homolog 4 isoform X1)
- Netrin g1a.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0045926 (negative regulation of growth), GO:0001763 (morphogenesis of a branching structure), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0032989 (cellular component morphogenesis), GO:0008038 (neuron recognition), GO:0048729 (tissue morphogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0048645 (animal organ formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001558 (regulation of cell growth), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0032535 (regulation of cellular component size), GO:0030030 (cell projection organization), GO:0031344 (regulation of cell projection organization), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0060284 (regulation of cell development), GO:0060973 (cell migration involved in heart development), GO:0002009 (morphogenesis of an epithelium), GO:0060029 (convergent extension involved in organogenesis), GO:0051960 (regulation of nervous system development), GO:0048666 (neuron development), GO:0061387 (regulation of extent of cell growth), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:0060914 (heart formation), GO:0050768 (negative regulation of neurogenesis), GO:0007414 (axonal defasciculation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0072359 (circulatory system development), GO:0030516 (regulation of axon extension), GO:0007417 (central nervous system development), GO:0030517 (negative regulation of axon extension), GO:0031345 (negative regulation of cell projection organization), GO:0060429 (epithelium development), GO:0010721 (negative regulation of cell development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0003318 (cell migration to the midline involved in heart development), GO:0021953 (central nervous system neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:0060026 (convergent extension), GO:0007411 (axon guidance), GO:0050771 (negative regulation of axonogenesis), GO:0021954 (central nervous system neuron development), GO:0031175 (neuron projection development), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0060974 (cell migration involved in heart formation), GO:0033564 (anterior/posterior axon guidance), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0021955 (central nervous system neuron axonogenesis), GO:0021952 (central nervous system projection neuron axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)