Protein: Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6) (Q9P104)
Organism: Homo sapiens (Human)
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Sequence: MASNFNDIVKQGYVRIRSRRLGIYQRCWLVFKKASSKGPKRLEKFSDERAAYFRCYHKVTELNNVKNVARLPKSTKKHAIGIYFNDDTSKTFACESDLEADEWCKVLQMECVGTRINDISLGEPDLLATGVEREQSERFNVYLMPSPNLDVHGECALQITYEYICLWDVQNPRVKLISWPLSALRRYGRDTTWFTFEAGRMCETGEGLFIFQTRDGEAIYQKVHSAALAIAEQHERLLQSVKNSMLQMKMSERAASLSTMVPLPRSAYWQHITRQHSTGQLYRLQDVSSPLKLHRTETFPAYRSEH
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [8-114]
- IPR037816: DOK4/5/6, PH domain (domain) [9-113]
- IPR002404: IRS-type PTB domain (domain) [130-237]
- IPR050996: Docking Protein Family (DOK) (family) [11-267]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1-235]
Interaction partners: - Proto-oncogene tyrosine-protein kinase receptor Ret
- Glial cell line-derived neurotrophic factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)