Protein: Sec14 cytosolic factor (Phosphatidylinositol/phosphatidyl-choline transfer protein) (PI/PC TP) (Sporulation-specific protein 20) (Q10137)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.
Subcellular location: Nucleus {ECO:0000269|PubMed:11294895}. Prospore membrane {ECO:0000269|PubMed:11294895}. Note=Nuclear, during meiosis. Associated with the forespore membrane during sporulation. During interphase found at the cell poles and during M-phase is located at both the cell poles and the medial region.
Sequence: MSETISDPYPLTNPNAPLGHPGHLNSTQQATLDSMRLELQKLGYTERLDDATLLRFLRARKFNLQQSLEMFIKCEKWRKEFGVDDLIKNFHYDEKEAVSKYYPQFYHKTDIDGRPVYVEQLGNIDLKKLYQITTPERMMQNLVYEYEMLALKRFPACSRKAGGLIETSCTIMDLKGVGITSIHSVYSYIRQASSISQDYYPERMGKFYVINAPWGFSSAFNLIKGFLDEATVKKIHILGSNYKSALLEQIPADNLPAKLGGNCQCPGGCELSDAGPWHEEQWMNKN
InterPro domains: - IPR001251: CRAL-TRIO lipid binding domain (domain) [94-267]
- IPR011074: CRAL/TRIO, N-terminal domain (domain) [46-74]
- IPR036273: CRAL/TRIO, N-terminal domain superfamily (homologous_superfamily) [8-89]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [82-286]
- IPR051026: Phosphatidylinositol/phosphatidylcholine transfer (family) [27-284]
Interaction partners: - Probable prefoldin subunit 3
- Membrane glycoprotein spo14
- Sporulation-specific protein 2
- Sporulation-specific protein 13
- Sporulation-specific protein 15
- Sporulation-specific protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0005515 (protein binding), GO:0005319 (lipid transporter activity), GO:0005548 (phospholipid transporter activity), GO:0120013 (lipid transfer activity), GO:0120014 (phospholipid transfer activity), GO:0008525 (phosphatidylcholine transporter activity), GO:0008526 (phosphatidylinositol transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0044107 (cellular alcohol metabolic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008204 (ergosterol metabolic process), GO:0008202 (steroid metabolic process), GO:0097384 (cellular lipid biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0044108 (cellular alcohol biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0016128 (phytosteroid metabolic process), GO:0006696 (ergosterol biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0016126 (sterol biosynthetic process), GO:0016129 (phytosteroid biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)