Protein: dTMP kinase (EC 2.7.4.9) (D3ZUJ5)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: GFLICGSWKPVPGLRSILFFRPLIKAKLNQGVTLVLDRYAFSGVAFTSAKENFSLDWCKQPDVGLPKPDLILFLQLQLLDAASRGEFGLERYETGTFQEQVLLCFQQLMSEKNLNWKVVDASKSIEDVHEEIRALSEDAIQNAAQRPLEELWK
InterPro domains: - IPR018095: Thymidylate kinase, conserved site (conserved_site) [35-47]
- IPR039430: Thymidylate kinase-like domain (domain) [20-132]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [14-153]
Interaction partners: - Thymidine kinase, cytosolic
- Thymidylate synthase
- Ribonucleoside-diphosphate reductase
- Thymidine kinase 2, mitochondrial
- Deoxycytidylate deaminase
- Adenylate kinase 9
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Nucleoside diphosphate kinase A
- Nucleoside diphosphate kinase B
- Nucleoside diphosphate kinase 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016776 (phosphotransferase activity, phosphate group as acceptor), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0050145 (nucleoside monophosphate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009719 (response to endogenous stimulus), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0061061 (muscle structure development), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0010038 (response to metal ion), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043627 (response to estrogen), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0045445 (myoblast differentiation), GO:0018130 (heterocycle biosynthetic process), GO:0019692 (deoxyribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0009262 (deoxyribonucleotide metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0046385 (deoxyribose phosphate biosynthetic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0009263 (deoxyribonucleotide biosynthetic process), GO:0046686 (response to cadmium ion), GO:0009394 (2'-deoxyribonucleotide metabolic process), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0009265 (2'-deoxyribonucleotide biosynthetic process), GO:0009133 (nucleoside diphosphate biosynthetic process), GO:0009219 (pyrimidine deoxyribonucleotide metabolic process), GO:0009147 (pyrimidine nucleoside triphosphate metabolic process), GO:0009138 (pyrimidine nucleoside diphosphate metabolic process), GO:0009186 (deoxyribonucleoside diphosphate metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006221 (pyrimidine nucleotide biosynthetic process), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009221 (pyrimidine deoxyribonucleotide biosynthetic process), GO:0009148 (pyrimidine nucleoside triphosphate biosynthetic process), GO:0009139 (pyrimidine nucleoside diphosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0031970 (organelle envelope lumen), GO:0070013 (intracellular organelle lumen), GO:0005758 (mitochondrial intermembrane space)