Protein: cDNA, FLJ96613, highly similar to Homo sapiens vacuolar protein sorting 33A (yeast) (VPS33A), mRNA (B2RDH6)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000256|ARBA:ARBA00004132}. Late endosome membrane {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004492}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004630}.
Sequence: MAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTLKGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMESEGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTYEGLIDEIYGIQNSYVKLPPEKFAPKKQGDGGKDLPTEAKKLQLNSAEELYAEIRDKNFNAVGSVLSKKAKIISAAFEERHNAKTVGEIKQFVSQLPHMQAARGSLANRTSIAELIKDVTTSEDFFDKLTVEQEFMSGIDTDKVNNYIEDCIAQKHSLIKVLRLVCLQSVCNSGLKQKVLDYYKREILQTYGYEHILTLHNLEKAGLLKPQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSVRLAQLLSRPGWRSIEEVLRILPGPHFEERQPLPTGLQKKRQPGENRVTLIFFLGGVTFAEIAALRFLSQLEDGGTEYVIATTKLMNGTSWIEALMEKPF
InterPro domains: - IPR043155: Vacuolar protein sorting-associated protein 33, domain 3b (homologous_superfamily) [368-459]
- IPR001619: Sec1-like protein (family) [26-591]
- IPR036045: Sec1-like superfamily (homologous_superfamily) [10-593]
- IPR043154: Sec1-like, domain 1 (homologous_superfamily) [1-143]
- IPR027482: Sec1-like, domain 2 (homologous_superfamily) [144-596]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043474 (pigment metabolic process involved in pigmentation), GO:0033059 (cellular pigmentation), GO:0050794 (regulation of cellular process), GO:0120305 (regulation of pigmentation), GO:0140352 (export from cell), GO:0048066 (developmental pigmentation), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0050931 (pigment cell differentiation), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0032940 (secretion by cell), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0048753 (pigment granule organization), GO:0030318 (melanocyte differentiation), GO:0035592 (establishment of protein localization to extracellular region), GO:0071705 (nitrogen compound transport), GO:0006508 (proteolysis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0009306 (protein secretion), GO:0010256 (endomembrane system organization), GO:0015031 (protein transport), GO:0030318 (melanocyte differentiation), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0006887 (exocytosis), GO:0007399 (nervous system development), GO:0009100 (glycoprotein metabolic process), GO:0015031 (protein transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0032400 (melanosome localization), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:0016050 (vesicle organization), GO:0018126 (protein hydroxylation), GO:0018193 (peptidyl-amino acid modification), GO:0048193 (Golgi vesicle transport), GO:0007030 (Golgi organization), GO:0071692 (protein localization to extracellular region), GO:0048699 (generation of neurons), GO:0030199 (collagen fibril organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0099023 (vesicle tethering complex), GO:0005829 (cytosol), GO:0048471 (perinuclear region of cytoplasm), GO:0098796 (membrane protein complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0030897 (HOPS complex), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0031091 (platelet alpha granule), GO:0005770 (late endosome), GO:0005769 (early endosome), GO:0030135 (coated vesicle), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane), GO:0030136 (clathrin-coated vesicle)