Protein: Phospholipid-transporting ATPase C887.12 (EC 7.6.2.1) (O94296)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P39524}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MARDVDNKQNAKRISRDEDEDEFAGESMVGRTLDNPFLGEDEFEDIFGSESQYISSSGQNSTNPFLADTRIENSPLGSESKANQLNKQGTNVNHIEIPLRDFNDPTQPESFLPPPKNTFTSRIKKIKNLFKKEKKQVKPEDLGPRQIILNDYSANHFLHNAVSTCKYSAFTFLPKFLKEQFSKYANLFFLFTAVVQQIPGITPVNRYTTIGPMLIVLSVSGIKEIMEDIKRKKQDQELNESPCYVLQGTGFVEKQWKDVVVGDIVKIVSETFFPADLVLLSSSEPEGLCYIETANLDGETNLKIKQALPETAGLLKPVELGQLSGEVKSEQPNNNLYTFDATLKLLPSDRELPLSPDQLLLRGAQLRNTPWVYGIVVFTGHESKLMKNTTETPIKRTSVEKQVNSQILFLLCIFVFLCFASSLGALIHRSVYGSALSYVKYTSNRAGMFFKGLLTFWILYSNLVPISLFVTFELVRYIQAQLISSDLDMYNEETDTPAACRTSSLVEELGQVGYIFSDKTGTLTRNQMEFRQCTIAGVAYADVIPEDRQFTSEDLDSDMYIYDFDTLKENLKHSENASLIHQFLLVLSICHTVIPEYDESTNSIKYQASSPDEGALVKGAASIGYKFLARKPHLVTVSIFGKDESYELLHICEFNSTRKRMSIVFRCPDGKIRLYVKGADTVIMERLASDNPYLQTTIHHLEDYATVGLRTLCIAMREVPEDEYQRWSTVFETAASSLVDRAQKLMDAAEEIEKDLILLGATAIEDRLQDGVPDTISTLQTAGIKIWVLTGDRQETAINIGMSCKLIDEDMGLVIVNEETKEATAESVMAKLSSIYRNEATTGNVESMALVIDGVSLTYALDFSLERRFFELASLCRAVICCRVSPLQKALIVKMVKRNTGEVLLAIGDGANDVPMIQAAHVGVGISGMEGLQAVRSSDFSISQFCYLKKLLLVHGSWCYQRLSKLILYSFYKNIALYMTQFWYAFCNAFSGQVIFESWSISLYNVLFTVLPPVVIGIFDQFVSAGQLFQYPQLYQLGQRSEFFNLKRFWSWITNGFYHSLLLFLCSIAVFYYDGPNKDGLASGHWVWGTTLYAAILATVLGKAALISNHWTQYTVIATLGSFLLWIVFMPIYAVAAPAIGFSKEYYGIIPHLYGNLKFWASLLVLPTIALMRDFVWKYSSRMYYPEEYHYVQEIQKYNVTDYRPRIVGFHKAIRKIRQMQRMRKQRGYAFSQGEEDQSRILDAYDTTHTRGAYGEMR
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [241-388]
- IPR001757: P-type ATPase (family) [877-991]
- IPR032630: P-type ATPase, C-terminal (domain) [935-1187]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [522-772]
- IPR036412: HAD-like superfamily (homologous_superfamily) [504-951]
- IPR006539: P-type ATPase, subfamily IV (family) [157-1194]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [498-958]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [518-524]
- IPR023214: HAD superfamily (homologous_superfamily) [760-945]
- IPR032631: P-type ATPase, N-terminal (domain) [150-210]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [157-1186]
Interaction partners: - Phospholipid-transporting ATPase accessory subunit mug89
- Uncharacterized protein C1604.12
- Plasma membrane ATPase 2
- Adhesion defective protein 1
- Translation initiation factor eIF2B subunit gamma
- Uncharacterized protein C1805.14
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0140326 (ATPase-coupled intramembrane lipid transporter activity), GO:0005319 (lipid transporter activity), GO:0140303 (intramembrane lipid transporter activity), GO:0005548 (phospholipid transporter activity), GO:0140327 (flippase activity), GO:0008525 (phosphatidylcholine transporter activity), GO:0140333 (glycerophospholipid flippase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0051234 (establishment of localization), GO:0019953 (sexual reproduction), GO:0065008 (regulation of biological quality), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0097035 (regulation of membrane lipid distribution), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:0034204 (lipid translocation), GO:0061024 (membrane organization), GO:0015914 (phospholipid transport), GO:0045332 (phospholipid translocation), GO:0015748 (organophosphate ester transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)