Protein: Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (UBA domain-containing protein 2) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14) (Q11119)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Sequence: MSCPHLTETNVVIPDNSQVIYREECVRCFNSQDEEGGIDLCLTCFQSGCGETGLKHSLVHFEQTLHPIVVTIARQPKQKINDEPPQKITKLEIREDSDEDLYDYFYVPKCLVCNIILDIQDPLLSLSLEAMKNATKASNKSQLTAWENELTTCDHIINLPENETYVTNLDNATCSKCDLAENLWMCLTCGALSCGRKQYGGGGGNGHALSHYDDTGHPLAVKLKSISPDGQADIYCYSCDEERIDPNIKTHMLNFGIDIAKLNKTEKSLAELQLEQNLNWDFGASEEDDASKRLFGPGLTGLKNLGNSCYLASTMQSLFSIKEFAIHELNLFNTYNSVCQTPTTDLQCQLGKLADGLVSGKFSKPSKIGLLNNPSSSILPYQDGLRPFMFKDVVGQGHSEFGTSQQQDAYEFLLYLLGKIRKSSIAKTDITKIFDFETEQKLSCLSCKRVRYSSFSSQGLTLTVPRVKIGEIEGEQIYEEVSIDQCLDATIQPDQMEYTCEACKSKLGATTTTAMKSFPKVLILQANRFDLQGYQVKKLSIPIIVNEDGIYNFDRLMAKDHPNDEDYLPEKTETIEWNQSAIEQLQAMGFPLVRCQRALLATGNSDTETAMNWLFEHMEDPEIDKPIEVSELLPKADSSVSEENVQSLCEFGFTVAQARKGLLESNNNIERAVDWILNHPDESFEEPPLEGSDSSIKNENMGSWESTNVPVNYNLKAIISHKGSSAHAGHYVAFIRKEIDGKQQWVLFNDEKVLQVASLEEAKTTGYVYLFERLD
InterPro domains: - IPR015940: Ubiquitin-associated domain (domain) [576-683]
- IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [164-774]
- IPR016652: Ubiquitinyl hydrolase (family) [1-775]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [301-731]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [300-771]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [5-246]
- IPR009060: UBA-like superfamily (homologous_superfamily) [636-679]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [296-775]
- IPR001607: Zinc finger, UBP-type (domain) [1-259]
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [300-774]
- IPR041432: Ubiquitinyl hydrolase, variant UBP zinc finger (domain) [11-78]
Interaction partners: - Ubiquitin carboxyl-terminal hydrolase 15
- Polyubiquitin
- Probable ubiquitin carboxyl-terminal hydrolase 2
- Ubiquitin carboxyl-terminal hydrolase 5
- Probable ubiquitin carboxyl-terminal hydrolase 7
- Ubiquitin carboxyl-terminal hydrolase 6
- Probable ubiquitin carboxyl-terminal hydrolase 9
- Putative ubiquitin thioesterase otu1
- Ubiquitin thioesterase otu2
- Probable mRNA-splicing protein ubp10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:1990380 (K48-linked deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0062014 (negative regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045912 (negative regulation of carbohydrate metabolic process), GO:0009057 (macromolecule catabolic process), GO:0043255 (regulation of carbohydrate biosynthetic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0010906 (regulation of glucose metabolic process), GO:0010677 (negative regulation of cellular carbohydrate metabolic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0045721 (negative regulation of gluconeogenesis), GO:0006111 (regulation of gluconeogenesis), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)