Protein: Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4) (Q8TD07)
Organism: Homo sapiens (Human)
Function: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular location: Membrane {ECO:0000269|PubMed:15240696}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.
Sequence: MRRISLTSSPVRLLLFLLLLLIALEIMVGGHSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGELTQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLFDAMNMTWTVINHEASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFLGHWEAMPEPTVSPVNASDIHWSSSSLPDRWIILGAFILLVLMGIVLICVWWQNGEWQAGLWPLRTS
InterPro domains: - IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [30-202]
- IPR011161: MHC class I-like antigen recognition-like (domain) [31-197]
- IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [29-202]
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [27-211]
Interaction partners: - NKG2-D type II integral membrane protein
- UL-16 binding protein 5
- UL16-binding protein 6
- Hematopoietic cell signal transducer
- T-cell surface glycoprotein CD8 alpha chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046703 (natural killer cell lectin-like receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0001906 (cell killing), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0002443 (leukocyte mediated immunity), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0001817 (regulation of cytokine production), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0002449 (lymphocyte mediated immunity), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0002718 (regulation of cytokine production involved in immune response), GO:0042267 (natural killer cell mediated cytotoxicity), GO:0010628 (positive regulation of gene expression), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0002228 (natural killer cell mediated immunity), GO:0010468 (regulation of gene expression), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0002717 (positive regulation of natural killer cell mediated immunity), GO:0002715 (regulation of natural killer cell mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)