Protein: Oxygen-independent coproporphyrinogen III oxidase (CPO) (EC 1.3.98.3) (Coproporphyrinogen III dehydrogenase) (CPDH) (P0A1E1)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen III to yield the vinyl groups in protoporphyrinogen IX.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P32131}.
Sequence: MSEQQIDWDLALIQKYNYSGPRYTSYPTALEFSEDFEDAAFLQAVARYPERPLSLYVHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIRHRAPLFADRHVSQLHWGGGTPTYLNKAQISRLMTLLRENFHFNTDAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHARDIGFTSTNIDLIYGLPKQTPESFAFTLKRVTELNPDRLSVFNYAHLPTLFAAQRKIKDADLPSAQQKLDILQETIVSLTQAGYQFIGMDHFARPDDELAVAQREGVLHRNFQGYTTQGDTDLLGMGVSAISMIGDGYMQNQKELKRYYQQVDERGNALWRGITLTRDDCIRRDVIKALICNFRLDFNAVEQQWGLHFAEYFAEDLQLLSPLAKDGLVDISEKGIQVTAKGRLLIRNICMCFDAYLRQKARMQQFSRVI
InterPro domains: - IPR007197: Radical SAM (domain) [47-280]
- IPR034505: Anaerobic coproporphyrinogen-III oxidase (family) [5-446]
- IPR006638: Elp3/MiaA/NifB-like, radical SAM core domain (domain) [52-272]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [46-268]
- IPR010723: HemN, C-terminal (domain) [363-432]
- IPR004558: Oxygen-independent coproporphyrinogen III oxidase HemN (family) [3-457]
Interaction partners: - Oxygen-dependent coproporphyrinogen-III oxidase
- Uroporphyrinogen decarboxylase
- Protoporphyrinogen IX dehydrogenase [quinone]
- Coproporphyrinogen III oxidase and related FeS oxidoreductase
- Ferrichrome-binding periplasmic protein
- Delta-aminolevulinic acid dehydratase
- Der GTPase-activating protein YihI
- Ferrochelatase
- Glutamyl-tRNA reductase
- Porphobilinogen deaminase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0033013 (tetrapyrrole metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033014 (tetrapyrrole biosynthetic process), GO:0006779 (porphyrin-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031469 (bacterial microcompartment)