Protein: Glutamate receptor 3 (GluR-3) (AMPA-selective glutamate receptor 3) (GluR-C) (GluR-K3) (Glutamate receptor ionotropic, AMPA 3) (P19492)
Organism: Rattus norvegicus (Rat)
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000269|PubMed:25524891}; Multi-pass membrane protein. Postsynaptic density membrane {ECO:0000269|PubMed:25524891, ECO:0000305|PubMed:10027300}.
Sequence: MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
InterPro domains: - IPR001508: Ionotropic glutamate receptor, metazoa (family) [462-842]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [418-829]
- IPR015683: Ionotropic glutamate receptor (family) [42-848]
- IPR001828: Receptor, ligand binding region (domain) [41-384]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [418-532]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [23-402]
Interaction partners: - Glutamate receptor 2
- Glutamate receptor 1
- Glutamate receptor 4
- Voltage-dependent calcium channel gamma-2 subunit
- PRKCA-binding protein
- Glutamate receptor-interacting protein 1
- Voltage-dependent calcium channel gamma-8 subunit
- Protein cornichon homolog 2
- Voltage-dependent calcium channel gamma-4 subunit
- Glutamate receptor ionotropic, NMDA 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015267 (channel activity), GO:0008066 (glutamate receptor activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022835 (transmitter-gated channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0004970 (ionotropic glutamate receptor activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0001101 (response to acid chemical), GO:0051602 (response to electrical stimulus), GO:0048167 (regulation of synaptic plasticity), GO:0021987 (cerebral cortex development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0021537 (telencephalon development), GO:0009410 (response to xenobiotic stimulus), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009636 (response to toxic substance), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0046685 (response to arsenic-containing substance), GO:0010035 (response to inorganic substance), GO:1901698 (response to nitrogen compound), GO:0060322 (head development), GO:0050806 (positive regulation of synaptic transmission), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0001919 (regulation of receptor recycling), GO:0030900 (forebrain development), GO:0019226 (transmission of nerve impulse), GO:0006810 (transport), GO:0046677 (response to antibiotic), GO:0042391 (regulation of membrane potential), GO:0021543 (pallium development), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:0099177 (regulation of trans-synaptic signaling), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0021510 (spinal cord development), GO:0050890 (cognition), GO:0071229 (cellular response to acid chemical), GO:0060992 (response to fungicide), GO:0043200 (response to amino acid), GO:0032355 (response to estradiol), GO:0071310 (cellular response to organic substance), GO:1990089 (response to nerve growth factor), GO:0050804 (modulation of chemical synaptic transmission), GO:1901699 (cellular response to nitrogen compound), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0001508 (action potential), GO:0007613 (memory), GO:0043434 (response to peptide hormone), GO:0007420 (brain development), GO:0032870 (cellular response to hormone stimulus), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0007399 (nervous system development), GO:0033993 (response to lipid), GO:0019228 (neuronal action potential), GO:0045838 (positive regulation of membrane potential), GO:0043331 (response to dsRNA), GO:0007417 (central nervous system development), GO:0016192 (vesicle-mediated transport), GO:0010226 (response to lithium ion), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0071363 (cellular response to growth factor stimulus), GO:0043279 (response to alkaloid), GO:0071375 (cellular response to peptide hormone stimulus), GO:0014075 (response to amine), GO:0071359 (cellular response to dsRNA), GO:0071407 (cellular response to organic cyclic compound), GO:1901653 (cellular response to peptide), GO:0006897 (endocytosis), GO:1990090 (cellular response to nerve growth factor stimulus), GO:0007616 (long-term memory), GO:0071230 (cellular response to amino acid stimulus), GO:0006898 (receptor-mediated endocytosis), GO:0031623 (receptor internalization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043204 (perikaryon), GO:0044297 (cell body), GO:0009986 (cell surface), GO:0030054 (cell junction), GO:0031984 (organelle subcompartment), GO:1990351 (transporter complex), GO:0031256 (leading edge membrane), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0043235 (receptor complex), GO:0044298 (cell body membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0031252 (cell leading edge), GO:0048786 (presynaptic active zone), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0098797 (plasma membrane protein complex), GO:0048787 (presynaptic active zone membrane), GO:1902495 (transmembrane transporter complex), GO:0043083 (synaptic cleft), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0031090 (organelle membrane), GO:0098802 (plasma membrane signaling receptor complex), GO:0032589 (neuron projection membrane), GO:0032809 (neuronal cell body membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0097447 (dendritic tree), GO:0043195 (terminal bouton), GO:0099634 (postsynaptic specialization membrane), GO:0098878 (neurotransmitter receptor complex), GO:0031253 (cell projection membrane), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0005769 (early endosome), GO:0032590 (dendrite membrane), GO:0098984 (neuron to neuron synapse), GO:0030659 (cytoplasmic vesicle membrane), GO:0097060 (synaptic membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0031594 (neuromuscular junction), GO:0043005 (neuron projection), GO:0060076 (excitatory synapse), GO:0005789 (endoplasmic reticulum membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0032279 (asymmetric synapse), GO:0044309 (neuron spine), GO:0098839 (postsynaptic density membrane), GO:0097708 (intracellular vesicle), GO:0008328 (ionotropic glutamate receptor complex), GO:0031901 (early endosome membrane), GO:0055038 (recycling endosome membrane), GO:0032281 (AMPA glutamate receptor complex)