Protein: Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (Q9PU40)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}.
Sequence: MPTPNISTSAAKGFRRAVSELDSKQAEAIMSPRFIGRRQSLIEDARKEREAAAAATDAAESTETIVFEEKDGRAMLNLFFMLKGAKTSPLSRALKVFETFEAKIHHLETRLSRKPREGTAELEYFVRCEVHSSDLNTFISSIKRVAEDVRTTKEDKFHWFPRKICELDKCHHLVTKFDPDLDLDHPGYSDQVYRQRRKSIAEIAFHYKHGDPIPRVEYTAEETATWKEVYSTLKSLYPTHACKEYLEAFNLLEKFCGYNENNIPQLEEVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADKTFAQFSQDIGLASLGATDEEIEKLATLYWFTVEFGLCRQNGIVKAYGAGLLSSYGELIHSLSDEPEVRDFDPDAAAVQPYQDQNYQPVYFVSESFSDAKNKLRNYAAHIKRPFSVKYEPYTHSIELLDSPQTICHSLESVRDELHSLINALNVIS
InterPro domains: - IPR041903: Tyrosine 3-monooxygenase, catalytic domain (domain) [159-456]
- IPR018301: Aromatic amino acid hydroxylase, iron/copper binding site (binding_site) [320-331]
- IPR019774: Aromatic amino acid hydroxylase, C-terminal (domain) [145-491]
- IPR005962: Tyrosine 3-monooxygenase (family) [38-490]
- IPR036951: Aromatic amino acid hydroxylase superfamily (homologous_superfamily) [151-491]
- IPR021164: Tyrosine hydroxylase, conserved site (conserved_site) [2-49]
- IPR001273: Aromatic amino acid hydroxylase (family) [51-490]
- IPR045865: ACT-like domain (homologous_superfamily) [68-163]
- IPR049321: Tyrosine 3-monooxygenase-like, ACT domain (domain) [73-142]
- IPR036329: Aromatic amino acid monoxygenase, C-terminal domain superfamily (homologous_superfamily) [157-489]
- IPR019773: Tyrosine 3-monooxygenase-like (family) [15-491]
Interaction partners: - Aromatic-L-amino-acid decarboxylase
- Pterin-4-alpha-carbinolamine dehydratase
- Pterin-4-alpha-carbinolamine dehydratase 2
- Dopamine beta-hydroxylase.
- Sepiapterin reductase.
- Aspartate aminotransferase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Dihydropteridine reductase
- Tyrosinase
- Tyrosine aminotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0097164 (ammonium ion metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:1901160 (primary amino compound metabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0042430 (indole-containing compound metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0009308 (amine metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0042428 (serotonin metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0018958 (phenol-containing compound metabolic process), GO:0042435 (indole-containing compound biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0006576 (biogenic amine metabolic process), GO:0042427 (serotonin biosynthetic process), GO:0006586 (indolalkylamine metabolic process), GO:0006568 (tryptophan metabolic process), GO:0046189 (phenol-containing compound biosynthetic process), GO:1901162 (primary amino compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043204 (perikaryon), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)