Protein: Actin-related protein 2/3 complex subunit 2-B (Q6IRB1)
Organism: Xenopus laevis (African clawed frog)
Function: Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (Probable). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q0IH88}. Cell projection {ECO:0000250|UniProtKB:Q0IH88}. Nucleus {ECO:0000269|PubMed:29925947}.
Sequence: MILLEVNNRIIEEILTLKFENAAAGNKPEVVEVTFADFDGVLYHVSNPNGDKAKVMISISLKFYKELQEHGADEVLKNVYGNFLVAPESGYNVSLLYDLEALPSNKDSVIHQAGMLKRNCFASVFEKYFKFQEEGKEGEKRAVIHYREDETMYVEAKKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTSANARDNTINLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFAAR
InterPro domains: - IPR034666: Arp2/3 complex subunit 2/4 (homologous_superfamily) [1-283]
- IPR007188: Actin-related protein 2/3 complex subunit 2 (family) [1-298]
Interaction partners: - Actin-related protein 2/3 complex subunit 4
- Actin-related protein 3-A
- Actin-related protein 2/3 complex subunit 3-A
- Actin-related protein 3-B
- Actin-related protein 2/3 complex subunit 3-B
- Actin-related protein 2/3 complex subunit 5-B
- Actin-related protein 2/3 complex subunit 1A-A
- Actin-related protein 2
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit 5-A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0030866 (cortical actin cytoskeleton organization), GO:0097435 (supramolecular fiber organization), GO:0044396 (actin cortical patch organization), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0006897 (endocytosis), GO:0045010 (actin nucleation), GO:0034314 (Arp2/3 complex-mediated actin nucleation), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)