Protein: Voltage-gated potassium channel KCNC1 (NGK2) (Potassium voltage-gated channel subfamily C member 1) (RAW2) (Voltage-gated potassium channel subunit Kv3.1) (Voltage-gated potassium channel subunit Kv4) (P25122)
Organism: Rattus norvegicus (Rat)
Function: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
Subcellular location: Cell membrane {ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:24161696}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:20857303}. Presynaptic cell membrane {ECO:0000269|PubMed:20857303}. Note=Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. {ECO:0000269|PubMed:20857303}.
Sequence: MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRADSKLNGEVAKAALANEDCPHIDQALTPDEGLPFTRSGTRERYGPCFLLSTGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT
InterPro domains: - IPR003974: Potassium channel, voltage dependent, Kv3 (family) [55-463]
- IPR028325: Voltage-gated potassium channel (family) [7-476]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [167-327]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [10-104]
- IPR005403: Potassium channel, voltage dependent, Kv3.1 (family) [138-489]
- IPR000210: BTB/POZ domain (domain) [8-112]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [5-122]
- IPR003968: Potassium channel, voltage dependent, Kv (family) [54-435]
- IPR005821: Ion transport domain (domain) [190-444]
Interaction partners: - A-type potassium channel modulatory protein KCNIP1
- A-type potassium channel modulatory protein KCNIP2
- Calsenilin
- A-type potassium channel modulatory protein DPP6
- Voltage-gated potassium channel subunit beta-1
- Kv channel-interacting protein 2x
- Kv channel-interacting protein 4
- Voltage-gated potassium channel subunit beta-2
- Inactive dipeptidyl peptidase 10
- Caveolin-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0044325 (transmembrane transporter binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022832 (voltage-gated channel activity), GO:0005251 (delayed rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0044304 (main axon), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:0098590 (plasma membrane region), GO:1902495 (transmembrane transporter complex), GO:0005783 (endoplasmic reticulum), GO:0098857 (membrane microdomain), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0005770 (late endosome), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0005769 (early endosome), GO:0044853 (plasma membrane raft), GO:0031982 (vesicle), GO:0008076 (voltage-gated potassium channel complex), GO:0005901 (caveola), GO:0097708 (intracellular vesicle), GO:0034703 (cation channel complex), GO:0030424 (axon), GO:0034705 (potassium channel complex)