Protein: GCN5-related N-acetyltransferase 1, chloroplastic (Q9C666)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA) and epsilon-lysine acetylation (KA), possibly with a low efficiency or toward specific plastid substrates. Involved in melatonin biosynthesis by catalyzing the formation of N-acetylserotonin (NAS) from serotonin and of melatonin (N-acetyl-5-methoxytryptamine) from 5-methoxytryptamine (5-MT)
Subcellular location: Plastid, chloroplast
Sequence: MFLGGTISTPPASLRLRSTLNPQNAVTQSSSQATFPAAMQRKPPSYSISDEDLESRGFLLRRTTEGLNLDQLNSVFAAVGFPRRDTAKIEVALQHTDALLWVEYEKTRRPVAFARATGDGVFNAIIWDVVVDPSFQSCGLGKAVMERLIEDLQVKGICNIALYSEPRVLGFYRPLGFVSDPDGIKGMVFIRKQRNKK
InterPro domains: - IPR045039: Acetyltransferase NSI-like (family) [26-193]
- IPR000182: GNAT domain (domain) [58-195]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [68-180]
Interaction partners: - Phenylacetaldehyde synthase
- Acetylserotonin O-methyltransferase
- GCN5-related N-acetyltransferase 10, chloroplastic
- Acyl-CoA N-acyltransferases (NAT) superfamily protein
- GCN5-related N-acetyltransferase 2, chloroplastic
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 8
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 6, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0043207 (response to external biotic stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0050832 (defense response to fungus), GO:0031326 (regulation of cellular biosynthetic process), GO:0006259 (DNA metabolic process), GO:0043604 (amide biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0010468 (regulation of gene expression), GO:0043043 (peptide biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0016573 (histone acetylation), GO:0006473 (protein acetylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018205 (peptidyl-lysine modification), GO:0043966 (histone H3 acetylation), GO:0018394 (peptidyl-lysine acetylation), GO:0006475 (internal protein amino acid acetylation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)