Protein: Phosphatidate cytidylyltransferase (A0A8M1Q7N6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MTELRRRGGGDQDSAENISDKEADGDDRLAFPDEGDGEMVGDSKAETPDAPPSTDNTPQCLNKALEGLSSRWKNWWIRGILSLTMIIGFFLIIYLGPIMLIIVVMGVQIKCFHEIITIGYRVYHSYELPWFRTLSWYFLICVNYFFYGETVADYFGALVQREEPLQFLVRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLIVVTQSHLVIQNLFEGMIWFIVPISIVICNDIMAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVLSFFFAYLLSQYQYFVCPVEYDSETNRFAVECEPSNLFMIQEYTLPAVVQNALRWKTVNLYPFQIHSIALSSFASLIGPFGGFFASGFKRAFKIKDFADTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLGIFNTLRNQLREKGLLPPAVEEAQ
InterPro domains: - IPR016720: Phosphatidate cytidylyltransferase, eukaryota (family) [43-444]
- IPR000374: Phosphatidate cytidylyltransferase (family) [364-390]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070567 (cytidylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009967 (positive regulation of signal transduction), GO:0001568 (blood vessel development), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:1902547 (regulation of cellular response to vascular endothelial growth factor stimulus), GO:1900746 (regulation of vascular endothelial growth factor signaling pathway), GO:0043408 (regulation of MAPK cascade), GO:0043410 (positive regulation of MAPK cascade), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)