Protein: Protein UL145 (F5HF44)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Plays a role in the inhibition of host innate immunity by exploiting host DDB1-cullin RING ubiquitin ligases (CRLs). Mechanistically, recruits host DDB1 via a DCAF-like interaction motif to antagonize IFN signaling by STAT2 degradation
Sequence: MYGVLAHYYSFISSPSVMVNFKHHNAVQLLCARTRDGTAGWERLTHHASYHANYGAYAVLMATSQRKSLVLHRYSAVTAVALQLMPVEMLRRLDQSDWVRGAWIVSETFPTSDPKGFWSDDDSPMGGSED
InterPro domains: - IPR057760: UL145-like, Cytomegalovirus (family) [1-130]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0009605 (response to external stimulus), GO:0044068 (modulation by symbiont of host cellular process), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0002684 (positive regulation of immune system process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0035821 (modulation of process of another organism), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009892 (negative regulation of metabolic process), GO:0051701 (biological process involved in interaction with host), GO:0075528 (modulation by virus of host immune response), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0075136 (response to host), GO:0060255 (regulation of macromolecule metabolic process), GO:0039503 (suppression by virus of host innate immune response), GO:0019054 (modulation by virus of host cellular process), GO:0031348 (negative regulation of defense response), GO:0044414 (suppression of host defenses by symbiont), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0002703 (regulation of leukocyte mediated immunity), GO:0032480 (negative regulation of type I interferon production), GO:0052031 (modulation by symbiont of host defense response), GO:0019049 (mitigation of host antiviral defense response), GO:0010468 (regulation of gene expression), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response), GO:0052562 (suppression by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component)