Protein: Alanine racemase, biosynthetic (P0A6B4)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis
Sequence: MQAATVVINRRALRHNLQRLRELAPASKMVAVVKANAYGHGLLETARTLPDADAFGVARLEEALRLRAGGITKPVLLLEGFFDARDLPTISAQHFHTAVHNEEQLAALEEASLDEPVTVWMKLDTGMHRLGVRPEQAEAFYHRLTQCKNVRQPVNIVSHFARADEPKCGATEKQLAIFNTFCEGKPGQRSIAASGGILLWPQSHFDWVRPGIILYGVSPLEDRSTGADFGCQPVMSLTSSLIAVREHKAGEPVGYGGTWVSERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGDPVILWGEGLPVERIAEMTKVSAYELITRLTSRVAMKYVD
InterPro domains: - IPR000821: Alanine racemase (family) [1-359]
- IPR011079: Alanine racemase, C-terminal (domain) [234-358]
- IPR009006: Alanine racemase/group IV decarboxylase, C-terminal (homologous_superfamily) [215-359]
- IPR029066: PLP-binding barrel (homologous_superfamily) [8-235]
- IPR020622: Alanine racemase, pyridoxal-phosphate attachment site (binding_site) [31-41]
- IPR001608: Alanine racemase, N-terminal (domain) [8-219]
Interaction partners: - D-alanine--D-alanine ligase B
- D-alanine--D-alanine ligase A
- UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- Alanine racemase, catabolic
- D-amino acid dehydrogenase
- D-amino acid dehydrogenase
- D-amino acid dehydrogenase
- Glutamate-pyruvate aminotransferase AlaA
- Glutamate-pyruvate aminotransferase AlaA
- Glutamate-pyruvate aminotransferase AlaA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016854 (racemase and epimerase activity), GO:0016855 (racemase and epimerase activity, acting on amino acids and derivatives), GO:0036361 (racemase activity, acting on amino acids and derivatives), GO:0047661 (amino-acid racemase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0006520 (amino acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0009063 (amino acid catabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009078 (pyruvate family amino acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009069 (serine family amino acid metabolic process), GO:0009071 (serine family amino acid catabolic process), GO:0046416 (D-amino acid metabolic process), GO:0006522 (alanine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)