Protein: 13 kDa ribonucleoprotein-associated protein (Q5ANL6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity)
Subcellular location: Nucleus, nucleolus
Sequence: MSAPNPKAFPLADSALTQQILDVVQQSQNLRQLKKGANEATKTLNRGISEFIIMAADTEPIEILLHLPLLCEDKNVPYVFVPSKAALGRACGVSRPVIAASVTSNDASSIKNQIYGIKDKIETLLI
InterPro domains: - IPR004037: Large ribosomal subunit protein eL8-like, conserved site (conserved_site) [71-88]
- IPR004038: Ribosomal protein eL8/eL30/eS12/Gadd45 (domain) [19-110]
- IPR029064: Ribosomal protein eL30-like superfamily (homologous_superfamily) [2-126]
- IPR002415: H/ACA ribonucleoprotein complex, subunit Nhp2-like (family) [6-92]
- IPR050257: Large ribosomal subunit protein eL8/uL1-like (family) [10-115]
- IPR018492: Ribosomal protein eL8/Nhp2 family (family) [33-92]
Interaction partners: - Nucleolar protein 56
- SnoRNA-binding rRNA-processing protein
- Rrp9p
- U4/U6-U5 snRNP complex subunit
- Nucleolar protein 58
- rRNA 2'-O-methyltransferase fibrillarin
- Utp4p
- U4/U6-U5 snRNP complex subunit
- U5 snRNP GTPase
- ATP-dependent RNA helicase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0097747 (RNA polymerase activity), GO:0016779 (nucleotidyltransferase activity), GO:0034062 (5'-3' RNA polymerase activity), GO:0003899 (DNA-directed 5'-3' RNA polymerase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005732 (sno(s)RNA-containing ribonucleoprotein complex)