Protein: Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Mitsugumin-33B) (Transmembrane protein 38B) (Q9DAV9)
Organism: Mus musculus (Mouse)
Function: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17611541}; Multi-pass membrane protein {ECO:0000269|PubMed:17611541}.
Sequence: MEYPWDDLTLAFSRTSMFPFFDIAHYLVSVMALKQRPGAVAAAWNNPLASWLSAMLHCFGGGILSCMLLAESPLKFLTNHTNILLASSIWYIVFFCPRDLVSQGYSYQPIQFLAAGMKEVTRTWKIVGGVSDANSYYRNAWIVMIVVGWARGAGGAVVTACEQLLKGDWKPEGDEWLKMSFPCKITLLGSIMFTFQHTRHLAISKHDLMFLYTIFLVTIKVTMMMTKDTAVTLTPFEDTLTRMLFGRRQQQQFSSSEKKTEVKPSSNGSASSASKRGAEPSGGAKRHAKKED
InterPro domains: - IPR007866: TRIC channel (family) [1-291]
Interaction partners: - Peptidyl-prolyl cis-trans isomerase FKBP10
- Cartilage-associated protein
- Prolyl 3-hydroxylase 1
- Membrane-bound transcription factor site-2 protease
- Interferon-induced transmembrane protein 5
- SEC24 homolog D, COPII coat complex component)
- Cyclic AMP-responsive element-binding protein 3-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005267 (potassium channel activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0051282 (regulation of sequestering of calcium ion), GO:0098660 (inorganic ion transmembrane transport), GO:0044057 (regulation of system process), GO:0034762 (regulation of transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0051283 (negative regulation of sequestering of calcium ion), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0098655 (monoatomic cation transmembrane transport), GO:0071417 (cellular response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0010256 (endomembrane system organization), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:1901699 (cellular response to nitrogen compound), GO:0051209 (release of sequestered calcium ion into cytosol), GO:0071702 (organic substance transport), GO:0090257 (regulation of muscle system process), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0019932 (second-messenger-mediated signaling), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0006996 (organelle organization), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0071415 (cellular response to purine-containing compound), GO:0006937 (regulation of muscle contraction), GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum), GO:0043279 (response to alkaloid), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0010959 (regulation of metal ion transport), GO:0019722 (calcium-mediated signaling), GO:0071407 (cellular response to organic cyclic compound), GO:0070588 (calcium ion transmembrane transport), GO:0008016 (regulation of heart contraction), GO:0007029 (endoplasmic reticulum organization), GO:0071312 (cellular response to alkaloid), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0006816 (calcium ion transport), GO:0014074 (response to purine-containing compound), GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion), GO:0055117 (regulation of cardiac muscle contraction), GO:0070296 (sarcoplasmic reticulum calcium ion transport), GO:0006942 (regulation of striated muscle contraction), GO:0031000 (response to caffeine), GO:0071313 (cellular response to caffeine), GO:0030001 (metal ion transport), GO:0051924 (regulation of calcium ion transport), GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0097553 (calcium ion transmembrane import into cytosol), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043227 (membrane-bounded organelle), GO:0016529 (sarcoplasmic reticulum), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)