Protein: CTP-dependent diacylglycerol kinase 1 (P87170)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of PA phosphatase ned1. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in pre-tRNA splicing
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein
Sequence: MSTKLTWSQWSKKHEIPRKALHTSIGFFALLLQGCGYHAAQIIPVIEIGFIPAFTGDVIRFNWPAFSRLYNRVIGPLMRESEKNAWNGVIFYMIGVWIVLKVFPEEIAVMSVLLLSWCDTTASTVGRKWGKYTPKIAKNKSLAGSLGAFVCGVFCCYVYWGLFRTGPDSLAAQSRIPFPWLCLINGFIGAFAEAMDVWGLDDNLVIPVVSACLLYLIM
InterPro domains: - IPR037997: CTP-dependent diacylglycerol kinase 1-like (family) [7-218]
Interaction partners: - Nuclear elongation and deformation protein 1
- Uncharacterized protein C23C11.01
- Uncharacterized acyltransferase C1851.02
- Putative phosphatidate cytidylyltransferase
- Putative lysophosphatidic acid:oleoyl-CoA acyltransferase
- Probable diacylglycerol pyrophosphate phosphatase 1
- Phospholipase D1
- Probable choline-phosphate cytidylyltransferase
- Lysophospholipid acyltransferase
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0004143 (diacylglycerol kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0006793 (phosphorus metabolic process), GO:0043647 (inositol phosphate metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0019751 (polyol metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046165 (alcohol biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0006646 (phosphatidylethanolamine biosynthetic process), GO:0046337 (phosphatidylethanolamine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0097038 (perinuclear endoplasmic reticulum), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)