Protein: Glutathione peroxidase 7 (GPx-7) (GSHPx-7) (EC 1.11.1.9) (CL683) (Q96SL4)
Organism: Homo sapiens (Human)
Function: It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Subcellular location: Secreted {ECO:0000305}.
Sequence: MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLILLKREDL
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [23-175]
- IPR000889: Glutathione peroxidase (family) [2-182]
- IPR013376: Glutathione peroxidase Gpx7, putative (family) [24-176]
- IPR029759: Glutathione peroxidase active site (active_site) [45-60]
- IPR029760: Glutathione peroxidase conserved site (conserved_site) [82-89]
Interaction partners: - Glutathione reductase, mitochondrial
- Peroxiredoxin-6
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
- Glutathione synthetase
- Polyunsaturated fatty acid 5-lipoxygenase
- Glutathione peroxidase 2
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Glutathione peroxidase 3
- Epididymal secretory glutathione peroxidase
- Phospholipid hydroperoxide glutathione peroxidase GPX4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004601 (peroxidase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor), GO:0042802 (identical protein binding), GO:0004602 (glutathione peroxidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:1901700 (response to oxygen-containing compound), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0006979 (response to oxidative stress), GO:0010033 (response to organic substance), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0000302 (response to reactive oxygen species), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043523 (regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0043202 (lysosomal lumen), GO:0005766 (primary lysosome)