Protein: Glutamate receptor IIA (RE27895p) (Q9VMP4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}.
Sequence: MRLCPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRSSKEKSRSKTVS
InterPro domains: - IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [428-829]
- IPR015683: Ionotropic glutamate receptor (family) [46-844]
- IPR001828: Receptor, ligand binding region (domain) [46-389]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [428-538]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [29-388]
Interaction partners: - Glutamate receptor IIB
- Bruchpilot, isoform J
- FI23915p1
- FI04462p
- Neuropilin and tolloid-like, isoform B
- Glutamate receptor IIC
- Fasciclin-2
- Vesicular glutamate transporter, isoform A
- NMDA receptor 2, isoform C
- Glutamate [NMDA] receptor subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0008066 (glutamate receptor activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0022835 (transmitter-gated channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0005262 (calcium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0004970 (ionotropic glutamate receptor activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0099604 (ligand-gated calcium channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0007154 (cell communication), GO:1903530 (regulation of secretion by cell), GO:0099536 (synaptic signaling), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:0060074 (synapse maturation), GO:0048731 (system development), GO:0006810 (transport), GO:0001505 (regulation of neurotransmitter levels), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0099177 (regulation of trans-synaptic signaling), GO:0060025 (regulation of synaptic activity), GO:0051588 (regulation of neurotransmitter transport), GO:0046928 (regulation of neurotransmitter secretion), GO:0007399 (nervous system development), GO:0050804 (modulation of chemical synaptic transmission), GO:0099537 (trans-synaptic signaling), GO:0071702 (organic substance transport), GO:0051046 (regulation of secretion), GO:0034330 (cell junction organization), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0098916 (anterograde trans-synaptic signaling), GO:0050808 (synapse organization), GO:0006816 (calcium ion transport), GO:0030001 (metal ion transport), GO:0007268 (chemical synaptic transmission), GO:0035249 (synaptic transmission, glutamatergic), GO:0007274 (neuromuscular synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098975 (postsynapse of neuromuscular junction), GO:0098797 (plasma membrane protein complex), GO:0099572 (postsynaptic specialization), GO:1902495 (transmembrane transporter complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0098878 (neurotransmitter receptor complex), GO:0034702 (ion channel complex), GO:0097482 (muscle cell postsynaptic specialization), GO:0031594 (neuromuscular junction), GO:0008328 (ionotropic glutamate receptor complex)