Protein: Adenosine deaminase RNA-specific B1a (A0A8M1P669)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MNEVGASGRPRGQQKFCSLDVDEDKHLSTCSMDVKENRNLDNLSSKEVLGEGPHLANGSARGLSRKRPLEEGNKGHGHSKFRPKKRRKPQGPILPKNALMQLNEIKPGLQYKLLSQTGPVHAPVFVMTVEVNGQLFEGSGPTKKKAKLNAAEKALRSFVQFPNASEAHLAMGRTLTVNADFTSDQADFPDMLFNGFETPVPPDDPFYLSLGSNGSLCSLKEYRLPVTLKYKNRPHPPLPLAPALTAPPTGSGKNAVMILNELRPGLKYEFVAESGESHAKNFIMSVTVDTQKFQGSGRNKKLAKARAAQAALSGLFNMQLDQTPSRQPIPREGLQLHLPQVLADAVSRLVVDKFSELTDNFSSPHARRKVLAGVVMTTGKDVMDAQVICVTTGTKCINGEYMSDRGLALNDCHAEIIARRSLIRYLYNQLEYFLSDSTEEHEKSIFRWCSEHGYRLKDDIQFHLYISTSPCGDARIFSPHEAGAEDQGDRHPNRKARGQLRTKIESGEGTIPVRTSNTIQTWDGVLQGERLLTMSCSDKIARWNVIGVQGSLLSYFTEPIYFSSLILGSLYHADHLSRAMYQRIADMDDIPPPFRINRPLLSGISNTEARQPGKAPNFSVNWTVGDQGLEIINATTGKDDLGRQSQLCKHALYSRWVCLHAKLSETLRIRGSRPGSYHEAKQGAVEYHEAKQTLFKAFYKAGLGAWVEKPIEQDQFSLTP
InterPro domains: - IPR002466: Adenosine deaminase/editase (domain) [341-717]
- IPR044459: ADAR2, second double-stranded RNA binding domain (domain) [251-320]
- IPR044458: ADAR2, first double-stranded RNA binding domain (domain) [91-162]
- IPR014720: Double-stranded RNA-binding domain (domain) [94-317]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0042802 (identical protein binding), GO:0019239 (deaminase activity), GO:0003723 (RNA binding), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0003725 (double-stranded RNA binding), GO:0004000 (adenosine deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042752 (regulation of circadian rhythm), GO:0019222 (regulation of metabolic process), GO:0007623 (circadian rhythm), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0009266 (response to temperature stimulus), GO:0002088 (lens development in camera-type eye), GO:0006979 (response to oxidative stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009409 (response to cold), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)