Protein: Mesogenin-1 (Paraxial mesoderm-specific mesogenin1) (pMesogenin1) (pMsgn1) (Q9JK54)
Organism: Mus musculus (Mouse)
Function: Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Sequence: MDNLGETFLSLEDGLDSSDTAGLLASWDWKSRARPLELVQESPTQSLSPAPSLESYSEVALPCGHSGASTGGSDGYGSHEAAGLVELDYSMLAFQPPYLHTAGGLKGQKGSKVKMSVQRRRKASEREKLRMRTLADALHTLRNYLPPVYSQRGQPLTKIQTLKYTIKYIGELTDLLNSSGREPRPQSV
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [118-178]
- IPR040259: Mesogenin/MesP (family) [1-180]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [109-178]
Interaction partners: - T-box transcription factor TBX6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0003205 (cardiac chamber development), GO:0009891 (positive regulation of biosynthetic process), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0003206 (cardiac chamber morphogenesis), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0001944 (vasculature development), GO:0003231 (cardiac ventricle development), GO:0010468 (regulation of gene expression), GO:0060976 (coronary vasculature development), GO:0030855 (epithelial cell differentiation), GO:0003208 (cardiac ventricle morphogenesis), GO:0003209 (cardiac atrium morphogenesis), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0003230 (cardiac atrium development), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0035051 (cardiocyte differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0007507 (heart development), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0051145 (smooth muscle cell differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0035886 (vascular associated smooth muscle cell differentiation), GO:0006355 (regulation of DNA-templated transcription), GO:0045446 (endothelial cell differentiation), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0003158 (endothelium development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0003228 (atrial cardiac muscle tissue development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)