Protein: Cytochrome c oxidase assembly factor 3, mitochondrial (Cytochrome c oxidase protein 25) (Required for respiratory growth protein 10) (Q3E7B2)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:20876281, ECO:0000269|PubMed:21068384}; Single-pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961, ECO:0000269|PubMed:20876281, ECO:0000269|PubMed:21068384}.
Sequence: MVLNPSKYQDTRTWKMTPAMIRARKPFFKGNMLGLTLLLGVTGSVYYYTYHFLHKDNDFADVPIPPIDPQELEALKKEYEAKKKA
InterPro domains: - IPR041752: Cytochrome c oxidase assembly factor 3, mitochondrial (family) [3-81]
Interaction partners: - Protein MSS51, mitochondrial
- Cytochrome c oxidase assembly protein COX14
- Cytochrome c oxidase assembly factor 1
- Cytochrome oxidase assembly protein SHY1
- Cytochrome c oxidase subunit 1
- Cytochrome b-c1 complex subunit 1, mitochondrial
- mRNA-binding protein PUF3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0016675 (oxidoreductase activity, acting on a heme group of donors), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0004129 (cytochrome-c oxidase activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0015078 (proton transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0017004 (cytochrome complex assembly), GO:0008535 (respiratory chain complex IV assembly), GO:0033617 (mitochondrial cytochrome c oxidase assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:1990204 (oxidoreductase complex), GO:0030964 (NADH dehydrogenase complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0045271 (respiratory chain complex I), GO:0043231 (intracellular membrane-bounded organelle), GO:0005747 (mitochondrial respiratory chain complex I), GO:0019866 (organelle inner membrane), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)