wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: F-box and leucine-rich repeat protein 14a (F-box/LRR-repeat protein 14a) (Fbxl14a protein) (Uncharacterized protein MGC40195) (Q6TGX5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MEIHISSLFPEILAMIFNYLDVKGKGRVAQVCTAWRDASYHKSVWRGVEAKLHLRRANPSLFPSLQTRGIKKVQILSLRRSLSYVIQGMPNIESLNLSGCYNLTDNGLGHAFVQDIPSLRILNLSLCKQITDSSLGRIAQYLKNLELLDLGGCSNITNTGLLLIAWGLHNLKSLNLRSCRHVSDVGIGHLAGMTRSAAEGCLTLEHLTLQDCQKLTDLSLKHISKGLNKLKVLNLSFCGGISDAGMIHLSHMTQLWTLNLRSCDNISDTGIMHLSMGALRLYGLDVSFCDKVGDQSLAYIAQGLYQLKSLSLCSCHISDDGINRMVRQMHELKTLNIGQCVRITDKGLELIADHLTQLTGIDLYGCTKITKRGLERITQLPCLKVLNLGLWQMTEVKGLGDASEILPLYAS
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [1-409]
- IPR047932: F-box/LRR-repeat protein 14, F-box domain (domain) [6-46]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [5-106]
- IPR001810: F-box domain (domain) [10-46]
- IPR001611: Leucine-rich repeat (repeat) [117-352]
- IPR006553: Leucine-rich repeat, cysteine-containing subtype (repeat) [89-380]
Interaction partners: - F-box only protein 11
- F-box and leucine-rich repeat protein 18.
- F-box only protein 11
- S-phase kinase-associated protein 1
- E3 ubiquitin-protein ligase RBX1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)
Protein: Zyxin (D4A7U1)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MRREAAGGPLQSLRPRAGPGPLPGGVSCPALPPRPLPAPSPGRSLYGLGAALSPPPPSLPLRVVPPRLARSCSGPGRRVRGLGAEAVIRDAALTLLPAQPGLTMAAPRPPPAISVSVSAPAFYAPQKKFAPVVAPKPKVNPFRPGDSESPVAAGAQRAQMGRVGEIPPPPPEDFPLPPPPVIGEGDDSEGALGGAFPPPPPPLIEEPFPPAPLEEDIFPSPPPPLEEEGGPEAPTQLPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFVPKPSTKPAPVGTAPLPPWKAPSSSQPPPQPQAKPQVQLHAQPQAKPHVQPQSVSSANTQPRGPLSQAPTPAPKFAPVAPKFTPVASKFSPGAPSGPGPQPSQKSVPLEAPSSVGTGSPQPPSFTYAQQKEKPLVQEKQHPLPPPAQNQNQVRSPGGPGPLTLKEVEELEQLTQQLMQDMEHPQRQSVAVNESCGKCSQPLARAQPAVRALGQLFHITCFTCHQCQQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGQPITDRMLRATGKAYHPHCFTCVVCACPLEGTSFIVDQANQPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKALSIEADDNGCFPLDGHVLCRKCHSARAQT
InterPro domains: - IPR001781: Zinc finger, LIM-type (domain) [477-667]
Interaction partners: - Vasodilator-stimulated phosphoprotein
- Talin 1
- Vinculin
- Talin 2
- Paxillin
- Alpha-actinin-4
- Alpha-actinin-1
- Actin, cytoplasmic 2
- Actin, cytoplasmic 1
- Breast cancer anti-estrogen resistance protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0032101 (regulation of response to external stimulus), GO:0080134 (regulation of response to stress), GO:0050727 (regulation of inflammatory response), GO:0031347 (regulation of defense response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0030055 (cell-substrate junction), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005925 (focal adhesion), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle)
Protein: High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (Q8AY96)
Organism: Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Sequence: MYGSGIFILLLLNFGAAEAMAEGGLCYILDGVLILYGIVLTILYCRLRMRSGNNEKNEENPDGIYQGLKHKNQDTYETLHVKKEPLA
InterPro domains: - IPR021663: T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit (family) [25-49]
- IPR003110: Phosphorylated immunoreceptor signalling ITAM (repeat) [54-82]
- IPR042340: High affinity immunoglobulin epsilon receptor subunit gamma (family) [6-85]
Interaction partners: - Tyrosine-protein kinase
- TYRO protein tyrosine kinase-binding protein
- Hepatic lectin isoform X1
- C-type lectin domain family 4 member E
- IgE receptor gamma.
- Tyrosine-protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)
Protein: Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (Heparin-binding protein HBp15) (P67984)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:36517592}.
Sequence: MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED
InterPro domains: - IPR002671: Large ribosomal subunit protein eL22 (family) [5-126]
- IPR038526: Large ribosomal subunit protein eL22 superfamily (homologous_superfamily) [7-128]
Interaction partners: - Large ribosomal subunit protein eL14
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL21
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL19
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL24
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Phospholipid/glycerol acyltransferase domain-containing protein (Q54X10)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MEKFSNWRDGPTGIHPLLPPKAKSVSVFGYIIKFVIGPIISIIRVPIILILTALLIIFNIIARSIPIGWLSRMICRFFDIIIGRIILLCMGFIQLDEFTETLSRSKVASGSIDQCTRKDIIICNHSSYVDIIYLCYKFSPTFAIPPNDEKNLNENIGKLIPLTLGRALENSIYSPIQLSSKSVDTNKLVESIQSSWNGPLVIFPEGTTSNGQGLLDISPIFPSQSQSQSQSQFNTFKEISANKLSIHVIGLSYHYGIYSPCYSSVGNVFLHLFLVCCQISNSIQIHYLSRSCMPPPPKQSQLSQYINNNGLSDENEWFDQLFKSLSSLINTRRTKITNNDKLSFISKWKGYKVDYSSKKSN
InterPro domains: - IPR002123: Phospholipid/glycerol acyltransferase (domain) [120-216]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity), GO:0071617 (lysophospholipid acyltransferase activity), GO:0016411 (acylglycerol O-acyltransferase activity), GO:0042171 (lysophosphatidic acid acyltransferase activity), GO:0003841 (1-acylglycerol-3-phosphate O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051235 (maintenance of location), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0019915 (lipid storage)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)
Protein: Dipeptidyl-peptidase 5 (DPP5) (EC 3.4.14.-) (MER034615) (B2RIT0)
Organism: Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)
Function: Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Prefers Ala and hydrophobic residues except Pro at the P1 position, and has no preference for P2 residues. Shows high dipeptidyl peptidase activity toward the synthetic substrates Lys-Ala-, Gly-Phe-, Met-Leu-, and Ser-Tyr-methylcoumaryl-7-amide (MCA), and slowly hydrolyzes Val-Tyr-MCA. Is likely involved in amino acid metabolism and bacterial growth of asaccharolytic P.gingivalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.
Subcellular location: Periplasm {ECO:0000269|PubMed:24398682}.
Sequence: MNKKIFSMMAASIIGSAAMTPSAGTNTGEHLTPELFMTLSRVSEMALSPDGKTAVYAVSFPDVKTNKATRELFTVNLDGSGRKQITDTESNEYAPAWMADGKRIAFMSNEGGSMQLWVMNADGTERRQLSNIEGGITGFLFSPDEKQVLFTKDIKFGKRTKDIYPDLDKATGRIITDLMYKHWDEWVETIPHPFIANATDGMITTGKDIMEGEPYEAPMKPWSGIEDFSWSPDGQNIAYASRKKTGMAYSLSTNSDIYIYNLTSGRTHNISEGMMGYDTYPKFSPDGKSIAWISMERDGYESDLKRLFVADLATGKRTHVNPTFDYNVDMIQWAPDSKGIYFLACKEAETNLWEITLKTGKIRQITQGQHDYADFSVRNDVMLAKRHSFELPDDLYRVNPKNGAAQAVTAENKAILDRLTPIACEKRWMKTTDGGNMLTWVVLPPDFDKNKKYPAILYCQGGPQNTVSQFWSFRWNLRLMAEQGYIVIAPNRHGVPGFGQKWNEQISGDYGGQNMRDYLTAVDEMKKEPYVDGDRIGAVGASYGGFSVYWLAGHHDKRFAAFIAHAGIFNLEMQYATTEEMWFANWDIGGPFWEKDNVVAQRTYATSPHKYVQNWDTPILMIHGELDFRILASQAMAAFDAAQLRGVPSEMLIYPDENHWVLQPQNALLFHRTFFGWLDRWLKK
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [424-684]
- IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [17-433]
- IPR001375: Peptidase S9, prolyl oligopeptidase, catalytic domain (domain) [471-684]
- IPR011659: WD40-like beta-propeller (repeat) [82-298]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0033218 (amide binding), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0042277 (peptide binding), GO:0008233 (peptidase activity), GO:0008238 (exopeptidase activity), GO:0008239 (dipeptidyl-peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006518 (peptide metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043171 (peptide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042597 (periplasmic space)
Protein: BZIP domain-containing protein (A7S7R0)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Not known
Sequence: MLEPTDVGLAEYLLNFPGVNCSQTPGIQEEKHDYFDHIEDPFEFDLNASSFHENHSENIMELPETGKSTSKKKNLTKISKRDEKANQKTTPASKRLKGKTVAKGERRQAAKVSMRSSQTRTLSTTLDDNKMTLKSETTKSKCSKECKKRINEKSNGKTVKENQFDDHTTSPNPTTTSTKGIKNKGKAMHNEGLVGDVDKVKTITVMKCLDANVSPTQLDMDRYVSDEGINRQAIMAKINREKKKQYVQELEGSVEEYKSKNAVLQKDCEDMKGLVKDLQMEIAYLKGVLANESQLAGLLKNIGNTDGVEFVGSVDKVNTLKRKASTTKESVKPSKISRPNGDTDYVNAAGVCLHVKSGKVSLEFCSKCNMSSSSDE
InterPro domains: - IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [236-282]
Interaction partners: - Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop domain-containing protein
- Uncharacterized protein
- WD repeat-containing protein 18
- Pre-rRNA-processing protein Ipi1 N-terminal domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Doublesex- and mab-3-related transcription factor 1A (xDmrt1) (DMRT1-alpha) (Q3LH63)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and germ cell proliferation. Acts both as a transcription repressor and activator.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Sequence: MQNNEEPYSKTRNSGQHPSGVHTKKSPRLPKCARCRNHGYASPLKGHKRYCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPIHLPIAAELLIKKEHGGSSSCLMLENSSTQTTSTPTSGSTASSEGKVLIQEIPSITSRGHMESTSDLVMDSPYYSNFYQPPLYPYYNNLYNYPPYQMAMAAESTSGNDMGGISGPPLKNNHRNHPAAYVPSQSGNQWQMKNRENRFPGHSGSSQFRMHSYYPPYLGQSVPNPACVPPFLTFEEIPSYSEAKASVLSPPSSQDSGVISLSSNSPVSNESTKAVAEQEPNSESSLFTVTTAAENGE
InterPro domains: - IPR001275: DM DNA-binding domain (domain) [28-81]
- IPR036407: DM DNA-binding domain superfamily (homologous_superfamily) [24-74]
- IPR026607: DMRT family (family) [19-280]
- IPR022114: Doublesex- and mab-3-related transcription factor 1-like (family) [86-158]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Pentatricopeptide repeat-containing protein At2g33680 (P93005)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MHPSTFQTELNPHTSTLLKKLTHHSQQRNLVAGRAVHGQIIRTGASTCIQHANVLVNFYAKCGKLAKAHSIFNAIICKDVVSWNSLITGYSQNGGISSSYTVMQLFREMRAQDILPNAYTLAGIFKAESSLQSSTVGRQAHALVVKMSSFGDIYVDTSLVGMYCKAGLVEDGLKVFAYMPERNTYTWSTMVSGYATRGRVEEAIKVFNLFLREKEEGSDSDYVFTAVLSSLAATIYVGLGRQIHCITIKNGLLGFVALSNALVTMYSKCESLNEACKMFDSSGDRNSITWSAMVTGYSQNGESLEAVKLFSRMFSAGIKPSEYTIVGVLNACSDICYLEEGKQLHSFLLKLGFERHLFATTALVDMYAKAGCLADARKGFDCLQERDVALWTSLISGYVQNSDNEEALILYRRMKTAGIIPNDPTMASVLKACSSLATLELGKQVHGHTIKHGFGLEVPIGSALSTMYSKCGSLEDGNLVFRRTPNKDVVSWNAMISGLSHNGQGDEALELFEEMLAEGMEPDDVTFVNIISACSHKGFVERGWFYFNMMSDQIGLDPKVDHYACMVDLLSRAGQLKEAKEFIESANIDHGLCLWRILLSACKNHGKCELGVYAGEKLMALGSRESSTYVQLSGIYTALGRMRDVERVWKHMRANGVSKEVGCSWIELKNQYHVFVVGDTMHPMIEETKDLVCLVSRQMIEEGFVTVLDSSFVEEEEGTQLSTSFII
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [4-675]
- IPR046960: Pentatricopeptide repeat-containing protein At4g14850-like, plant (family) [338-684]
- IPR002885: Pentatricopeptide repeat (repeat) [53-535]
- IPR046848: E motif (repeat) [605-667]
Interaction partners: - Putative defensin-like protein 148
- Putative F-box protein At2g33655
- Poly
- 187-kDa microtubule-associated protein AIR9
- Poly
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0016070 (RNA metabolic process), GO:0009451 (RNA modification), GO:1900864 (mitochondrial RNA modification), GO:0016071 (mRNA metabolic process), GO:0000959 (mitochondrial RNA metabolic process), GO:0016556 (mRNA modification), GO:0080156 (mitochondrial mRNA modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Apolipoprotein D (Apo-D) (ApoD) (P23593)
Organism: Rattus norvegicus (Rat)
Function: APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Subcellular location: Secreted.
Sequence: MATMLLLLATLAGLFTTTEGQSFHLGKCPSPPVQENFDVKKYLGRWYEIEKIPVSFEKGNCIQANYSLMENGNIKVLNKELRPDGTLNQVEGEAKQSNMSEPAKLEVQFFSLMPPAPYWILATDYESYALVYSCTTFFWFFHVDYVWILGRNPYLPPETITYLKYILTSNDIDIAKITTKDQANCPDFL
InterPro domains: - IPR026222: Apolipoprotein D, vertebrates (family) [5-186]
- IPR012674: Calycin (homologous_superfamily) [4-188]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [37-180]
- IPR022272: Lipocalin family conserved site (conserved_site) [36-49]
- IPR002969: Apolipoprotein D (family) [20-185]
- IPR022271: Lipocalin, ApoD type (family) [3-188]
Interaction partners: - Apolipoprotein A-II
- Clusterin
- Apolipoprotein C-I
- Apolipoprotein E
- Apolipoprotein A-IV
- Apolipoprotein F
- Apolipoprotein M
- Apolipoprotein C-III
- Beta-2-glycoprotein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0006979 (response to oxidative stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0005794 (Golgi apparatus), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030424 (axon)