Protein: Homogentisate 1,2-dioxygenase (EC 1.13.11.5) (Homogentisate oxygenase) (Homogentisic acid oxidase) (Homogentisicase) (Q9ZRA2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MEEKKKELEELKYQSGFGNHFSSEAIAGALPLDQNSPLLCPYGLYAEQISGTSFTSPRKLNQRSWLYRVKPSVTHEPFKPRVPAHKKLVSEFDASNSRTNPTQLRWRPEDIPDSEIDFVDGLFTICGAGSSFLRHGFAIHMYVANTGMKDSAFCNADGDFLLVPQTGRLWIETECGRLLVTPGEIAVIPQGFRFSIDLPDGKSRGYVAEIYGAHFQLPDLGPIGANGLAASRDFLAPTAWFEDGLRPEYTIVQKFGGELFTAKQDFSPFNVVAWHGNYVPYKYDLKKFCPYNTVLLDHGDPSINTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIYGAYEAKADGFLPGGASLHSCMTPHGPDTTTYEATIARVNAMAPSKLTGTMAFMFESALIPRVCHWALESPFLDHDYYQCWIGLKSHFSRISLDKTNVESTEKEPGASE
InterPro domains: - IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [274-411]
- IPR005708: Homogentisate 1,2-dioxygenase (family) [9-442]
- IPR046451: Homogentisate 1,2-dioxygenase, C-terminal domain (domain) [286-440]
- IPR011051: RmlC-like cupin domain superfamily (homologous_superfamily) [11-441]
- IPR046452: Homogentisate 1,2-dioxygenase, N-terminal domain (domain) [12-285]
Interaction partners: - 4-hydroxyphenylpyruvate dioxygenase
- Glutathione S-transferase Z2
- Glutathione S-transferase Z1
- Fumarylacetoacetase
- Oxaloacetate tautomerase FAHD1, mitochondrial
- At5g13560
- Oxaloacetate tautomerase FAHD2, mitochondrial
- Aspartate aminotransferase, cytoplasmic isozyme 2
- Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial
- Alpha-aminoadipic semialdehyde synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0005515 (protein binding), GO:0051213 (dioxygenase activity), GO:0016701 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen), GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0016054 (organic acid catabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0019439 (aromatic compound catabolic process), GO:0009063 (amino acid catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006570 (tyrosine metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0009074 (aromatic amino acid family catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0006558 (L-phenylalanine metabolic process), GO:1902222 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process), GO:1902221 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process), GO:0006572 (tyrosine catabolic process), GO:0006559 (L-phenylalanine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)