wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Alkali-sensitive linkage protein 1 (Q09788)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Golgi apparatus {ECO:0000269|PubMed:16823372}. Secreted, cell wall {ECO:0000269|PubMed:17230583}. Note=Covalently attached to the cell wall. {ECO:0000269|PubMed:17230583}.
Sequence: MRTTFATVALAFLSTVGALPYAPNHRHHRRDDDGVLTVYETILETVYVTAVPGANSSSSYTSYSTGLASVTESSDDGASTALPTTSTESVVVTTSAPAASSSATSYPATFVSTPLYTMDNVTAPVWSNTSVPVSTPETSATSSSEFFTSYPATSSESSSSYPASSTEVASSYSASSTEVTSSYPASSEVATSTSSYVAPVSSSVASSSEISAGSATSYVPTSSSSIALSSVVASASVSAANKGVSTPAVSSAAASSSAVVSSVVSSATSVAASSTISSATSSSASASPTSSSVSGKRGLAWIPGTDLGYSDNFVNKGINWYYNWGSYSSGLSSSFEYVLNQHDANSLSSASSVFTGGATVIGFNEPDLSAAGNPIDAATAASYYLQYLTPLRESGAIGYLGSPAISNVGEDWLSEFMSACSDCKIDFIACHWYGIDFSNLQDYINSLANYGLPIWLTEFACTNWDDSNLPSLDEVKTLMTSALGFLDGHGSVERYSWFAPATELGAGVGNNNALISSSGGLSEVGEIYIS
InterPro domains: - IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [359-501]
- IPR024655: Asl1-like, glycosyl hydrolase catalytic domain (domain) [298-528]
- IPR053183: Alkali-sensitive linkage protein (family) [230-530]
Interaction partners: - 1,3-beta-glucanosyltransferase gas5
- 1,3-beta-glucanosyltransferase gas1
- Uncharacterized WD repeat-containing protein C17D11.16
- Small ribosomal subunit protein bS18m
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044248 (cellular catabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0016052 (carbohydrate catabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0005976 (polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0044247 (cellular polysaccharide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030312 (external encapsulating structure), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0009277 (fungal-type cell wall)
Protein: Forkhead box protein D5-A (FoxD5-A) (FoxD5a) (Fork head domain-related protein 12) (xFD-12) (XlFoxD5a) (Q9PRJ8)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor with a role in dorsal axis formation and neural plate expansion; maintains an undifferentiated neural ectoderm after neural induction.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:11401404}.
Sequence: MSFSQESGAHHHPQDYAGLSDEEDEIDILGEDDPCSLKSHFYLQPTHSVMGDSEMLSPSKLSCTESESDSSGESEGGTSKDSSTTPTGSKAKRTLVKPPYSYIALITMAILQSPHKKLTLSGICDFISSKFPYYKDKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPASEDMFDNGSFLRRRKRFKRHQQEFFKDGLMMYNSLPYYRPYSAIQPQPVLQQTSLTCMAIPETLPMSTHLAPYPDIKRKVSYPAQGVHRGFKAQDADNHPNNSQSKCSFSIENIMRKPKEPEPNIQSFNSHWNYNHVFQRPSSCLLPAVLNLSTGPLLANTQGARQYNLIQFPGCY
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [96-191]
- IPR050211: Forkhead box domain-containing protein (family) [59-318]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [141-147]
- IPR001766: Fork head domain (domain) [95-191]
- IPR018122: Fork head domain conserved site1 (conserved_site) [97-110]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [84-192]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0009790 (embryo development), GO:0060429 (epithelium development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001840 (neural plate development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Lamin-B1 (P14733)
Organism: Mus musculus (Mouse)
Function: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Subcellular location: Nucleus lamina {ECO:0000269|PubMed:28241138}.
Sequence: MATATPVQQQRAGSRASAPATPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKFKAEHDQLLLNYAKKESDLSGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLSAAKKQLADETLLKVDLENRCQSLTEDLEFRKNMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDMLAKERDNSRRMLSDREREMAEIRDQMQQQLSDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTVWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEEPIGVAVEEERFHQQGAPRASNKSCAIM
InterPro domains: - IPR001322: Lamin tail domain (domain) [431-547]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [375-383]
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [401-549]
- IPR039008: Intermediate filament, rod domain (domain) [32-389]
Interaction partners: - Prelamin-A/C
- Delta
- Lamin-B2
- SUN domain-containing protein 1
- Emerin
- Barrier-to-autointegration factor
- SUN domain-containing protein 2
- Caspase-6
- Nesprin-2
- Nesprin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005200 (structural constituent of cytoskeleton), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0050954 (sensory perception of mechanical stimulus), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031975 (envelope), GO:0031974 (membrane-enclosed lumen), GO:0005652 (nuclear lamina), GO:0034399 (nuclear periphery), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)
Protein: Serine/threonine-protein kinase ppk11 (EC 2.7.11.1) (O14047)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Note=Located at the septum.
Sequence: MEKHQYRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERSKFSRAFCDFVSNCLKKNPKDRATAEYLSKHKFIKKYCPNTSVKEVVASYAKWKESELLPEATPYNSTMGNSANTIDEVVWDFGTVRR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [4-265]
- IPR050629: STE20/SPS1-related Proline-Alanine-rich Kinase (family) [3-279]
- IPR017441: Protein kinase, ATP binding site (binding_site) [12-35]
- IPR000719: Protein kinase domain (domain) [6-258]
Interaction partners: - Mo25-like protein
- Leucine-rich repeat-containing protein sog2
- cAMP-dependent protein kinase regulatory subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0032878 (regulation of establishment or maintenance of cell polarity), GO:0007264 (small GTPase mediated signal transduction), GO:0007265 (Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005816 (spindle pole body), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0044732 (mitotic spindle pole body), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)
Protein: Zinc finger BED domain-containing protein RICESLEEPER 3 (Transposase-like protein RICESLEEPER 3) (Q75HY5)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transposase-like protein that is essential for plant growth and development. May regulate global gene expression by recruiting other cellular factors.
Subcellular location: Nucleus {ECO:0000269|PubMed:23067104}.
Sequence: MCEPSGSDDAMVHASEMVDGDEMIHGNEMVVHDSVMIDGNEMVQENVMVHGSGEMVQGSEMVHNNEIIQVNDMIQVNEMVNGDKMAHGHELVGVELTTPTASRRRRKKSVVWEHFTIEEMPGGVSRASCNLCKQTFAYSCGSKISGTSHLKRHITLASCPMLKNEDMKLSLPLATVTNNDGEGCAERVAKRHYRSTGYANAMFDQDRTCSNLAKMIILHDYPLHIVEQRGFTAFIGSLQPRFRVIDVDTIEGQVHSVYQKERENLMHVFSTVPGRISLTVRLWATSQTLGYISLAAQFIDTEWRVHRRMVNFMMVSSPHSENSLSEAISTSLSDWNMKDKLFTITLDNDPSSHDIYSANMINYLSNKKDNIMIKGQLFVVRCYAHILNTVAQDVIASVHSVIYHIRESIKFIKASSVHEDKFAEIALQLEIPSAKTLCLDVTTQWNTTYLMLLAALDYQQVFASLETCDGDYNEAPSTEDWKKVEAACSYLSLLYDSAHNIMAAPNPTSNIFFHEAWKLQSELSNAIAHEDPIFRSTAKIMHERFDKYWKDCNLVLAIAVVMDPRFKMKLVEFSYSKIHSVEAAKYVKVVDDAIHELYSEYATQGEANRDAHVTDNSAAVTPPNGDELLDFDIYLSEIATSQPSISELEQYLEEALMPRIQDFEILEWWKLNTIKFPTLSKMARDVLAIPMSMVSSGSSIFSATATGSQMLDDYRSSLRPETVEALFCAKDWLQYPPATTEAPSTALVKMEN
InterPro domains: - IPR052035: Zinc finger BED domain-containing (family) [85-734]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [109-156]
- IPR025525: hAT-like transposase, RNase-H fold (domain) [506-601]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [270-734]
- IPR003656: Zinc finger, BED-type (domain) [106-166]
- IPR008906: HAT, C-terminal dimerisation domain (domain) [647-733]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0007275 (multicellular organism development), GO:0009791 (post-embryonic development), GO:0048856 (anatomical structure development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL (EC 2.7.1.121) (P76014)
Organism: Escherichia coli (strain K12)
Function: ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone bound to DhaK. DhaL acts also as coactivator of the transcription activator DhaR by binding to the sensor domain of DhaR. In the presence of dihydroxyacetone, DhaL-ADP displaces DhaK and stimulates DhaR activity. In the absence of dihydroxyacetone, DhaL-ADP is converted by the PTS to DhaL-ATP, which does not bind to DhaR.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MSLSRTQIVNWLTRCGDIFSTESEYLTGLDREIGDADHGLNMNRGFSKVVEKLPAIADKDIGFILKNTGMTLLSSVGGASGPLFGTFFIRAAQATQARQSLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPVALEAASSIAESAAQSTITMQARKGRASYLGERSIGHQDPGATSVMFMMQMLALAAKE
InterPro domains: - IPR012737: Dihydroxyacetone kinase, subunit L (domain) [9-205]
- IPR036117: DhaL domain superfamily (homologous_superfamily) [1-210]
- IPR050861: Dihydroxyacetone Kinase (DAK) (family) [17-208]
- IPR004007: DhaL domain (domain) [6-206]
Interaction partners: - PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
- PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM
- PTS-dependent dihydroxyacetone kinase operon regulatory protein
- Glycerol dehydrogenase
- Anaerobic glycerol-3-phosphate dehydrogenase subunit A
- Aerobic glycerol-3-phosphate dehydrogenase
- Glycerol-3-phosphate dehydrogenase [NAD
- Anaerobic glycerol-3-phosphate dehydrogenase subunit B
- Anaerobic glycerol-3-phosphate dehydrogenase subunit C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009069 (serine family amino acid metabolic process), GO:0046416 (D-amino acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Leucine-rich repeat-containing protein (Q4GZE0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MHSLRSNKQEARVDNDPLQEVDYSYNVQQLQAEFHVLPPSEAYRELCFRHQCKPINSVANLFSSCVGEWNVTTHLDFSQSYIGPKGVRPVVELCKRLPALKSFNCANNYLTNNAVYFISRMAAFHPSLERLELSFNEFISWTGGNFLYELTLCNSNIKEVGVLHTKIPPNVAEEIFRQSRCNCVLVYQAMGRPPKQSSHPEAIHLRAMKRFFNDMQENGTVPASALVEGHRERCRILGEAYDASKYTKAFYDELSSRLPQDNISWEAFIITLKLDGSVYNEEAVKKLRRLFLEFNMEPTAELDGFVEVRDLPAMCTRLNNEHAPSTVIKNMCDVLGLDDTMTLQWDEFLSLMYNSVATNMEHGVNLRMASPHSAVKMLHL
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [206-352]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [3-207]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0007017 (microtubule-based process), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0060285 (cilium-dependent cell motility), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0070286 (axonemal dynein complex assembly), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)
Protein: Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) (Q55GD9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MSNQVFQFPPYYHKEPFFTIQPILNTRKKQFQMWQDLILQYCRYYKIYELDINESIKSNSVLFNNEKINRKLSREALKSIIDDIIENGFAEWVDKEKEKEKEKDKDNNNNNRVLIMWRKPDEWASLIYKWVADCGLLNTVLTVWEIQNGDDSKKQEFHQLNTTILMKSLKVLEKQSKCQTFSQDENVGVKFFSI
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [6-191]
- IPR014041: ESCRT-II complex, Vps25 subunit, N-terminal winged helix (homologous_superfamily) [5-116]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [117-192]
- IPR008570: ESCRT-II complex, Vps25 subunit (family) [4-192]
Interaction partners: - Vacuolar-sorting protein SNF8
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein sorting-associated protein 28
- Charged multivesicular body protein 6
- Charged multivesicular body protein 4
- Charged multivesicular body protein 3
- ESCRT-I complex subunit tsg101
- Charged multivesicular body protein 1
- Charged multivesicular body protein 7
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0048856 (anatomical structure development), GO:0044237 (cellular metabolic process), GO:0099120 (socially cooperative development), GO:0071840 (cellular component organization or biogenesis), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0006914 (autophagy), GO:0044085 (cellular component biogenesis), GO:0044248 (cellular catabolic process), GO:0016043 (cellular component organization), GO:0030587 (sorocarp development), GO:0016236 (macroautophagy), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007033 (vacuole organization), GO:1905037 (autophagosome organization), GO:0000045 (autophagosome assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)