Protein: NADH-ubiquinone oxidoreductase 49 kDa subunit (EC 7.1.1.2) (NADH dehydrogenase subunit 7) (Q23883)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O75306}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75306}; Matrix side {ECO:0000250|UniProtKB:O75306}.
Sequence: MLNISKIFEEVKVMKNFTLNFGPQHPAAHGVLRLIVELESENVVRVEPHIGLLHRGTEKLIEGKTYTQALPYFDRLDYVSMNVQEHAYSLAVERLYLDSLDIELEIPQRAKVIRVLFSEITRVLNHIMATTTHAMDVGALTPFLWAFEEREKLMEFYERVSGARMHAAYIRPGGVAFDLPMNISEDIYKFVIQYRKRLEEIEDMLINNRIWKQRLVDIGIVSAEEALNYGFTGPLLRGAGIVYDIRKNYPYDDYDKYDFKIIIGEENNSYTRFIIRMKEMYQSLSIIEQALNNLRPGLIKLEGVNITAPDRAFVKKDMESCINHFKFFSEGFIIPANENYTIVEAPKGEFGIYLNANDTAKPYRCRIKAPGFLHLQGLNMMSKDHLLADVVTLIGTQDIVFGEVDR
InterPro domains: - IPR029014: [NiFe]-hydrogenase, large subunit (homologous_superfamily) [16-406]
- IPR022885: NAD(P)H-quinone oxidoreductase subunit D/H (family) [8-406]
- IPR001135: NADH-quinone oxidoreductase, subunit D (domain) [136-406]
- IPR014029: NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site (conserved_site) [53-64]
Interaction partners: - NADH dehydrogenase 1 alpha subcomplex subunit 9
- NADH-ubiquinone oxidoreductase chain 1
- NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Ribosomal protein/NADH dehydrogenase domain-containing protein
- Deoxyguanosine kinase
- NADH dehydrogenase iron-sulfur protein 7
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit
- NADH dehydrogenase 1 alpha subcomplex subunit 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0043934 (sporulation), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0051716 (cellular response to stimulus), GO:0099120 (socially cooperative development), GO:0006950 (response to stress), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0001666 (response to hypoxia), GO:0010035 (response to inorganic substance), GO:0042594 (response to starvation), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0030435 (sporulation resulting in formation of a cellular spore), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0010033 (response to organic substance), GO:0030587 (sorocarp development), GO:0071456 (cellular response to hypoxia), GO:0010038 (response to metal ion), GO:0071241 (cellular response to inorganic substance), GO:0071453 (cellular response to oxygen levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0014070 (response to organic cyclic compound), GO:0031669 (cellular response to nutrient levels), GO:0071248 (cellular response to metal ion), GO:0036294 (cellular response to decreased oxygen levels), GO:0046686 (response to cadmium ion), GO:0046688 (response to copper ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)