Protein: Activator of SUMO 1 (CG12276 protein) (CG12276-PA) (LD33652p) (Q7KSM5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MVVDMDTSETAVELTEAENELYDRQIRLWGLESQKRLRTAKILIAGLCGLGAEITKNIILSGVNSVKLLDDKDVTEEDFCSQFLVPRESLNTNRAEASLTRARALNPMVDISADREPLKEKTSEFFGQFDVVVVNGATNEELLRIDTICRDLGVKFIATDVWGTFGFYFASLQKHSYVEDVIKHKVVANSEKKKKYETVSIPTQRDVDYPGYSAWLDFDVTEPSYLRKLKRNGPGVLLLSVLQKFRTTHKRDPSYKTREADLELLRGIRDELLPNSILGDEALGLIFAQISPAVAVVGGVVAQEVIKVVTKLEAPHRNLFVFDPETCAGYVEAIGAK
InterPro domains: - IPR000594: THIF-type NAD/FAD binding fold (domain) [22-324]
- IPR045886: ThiF/MoeB/HesA family (family) [17-326]
- IPR000011: Ubiquitin/SUMO-activating enzyme E1-like (family) [43-186]
- IPR035985: Ubiquitin-activating enzyme-like (homologous_superfamily) [15-332]
Interaction partners: - SUMO-activating enzyme subunit
- Dorsal interacting protein 4
- Small ubiquitin-related modifier
- Suppressor of variegation 2-10, isoform I
- Nedd8-conjugating enzyme UbcE2M
- DNA repair protein Rad60
- GH15225p
- E3 SUMO-protein ligase RanBP2
- Ubiquitin-like protein NEDD8
- Molybdopterin synthase catalytic subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0044390 (ubiquitin-like protein conjugating enzyme binding), GO:0031624 (ubiquitin conjugating enzyme binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0051726 (regulation of cell cycle), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0007346 (regulation of mitotic cell cycle), GO:0043412 (macromolecule modification), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:2001141 (regulation of RNA biosynthetic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0018193 (peptidyl-amino acid modification), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018205 (peptidyl-lysine modification), GO:0032446 (protein modification by small protein conjugation), GO:0016925 (protein sumoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)