Protein: Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide] (P38845)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Cruciform DNA-binding protein which exerts an enhancing effect on the cleavage of cruciform DNA (X-DNA) by endonuclease VII from bacteriophage T4.
Sequence: MSSELMFNYTFSWPAGPKDVILTGTFDDWRGTLPLVKTAKGNFEITMPVKLANKDDTFQFKFIVDGVWCVSDSYKKEHVSEGIENNFLQITDLVETQEVAGASRIPEAGGLLCGKPPRSAGPPSTSNRKKNKRNNKKRRSKLKKKSTKNNKKSNESLDDNEEEDGVTGTTTEDVTGTSREETPLAEPTNVSKEAPGNFHILPIDQSADTTQSNGIIGGPGPVLVPNPGEIKEFTEIRDVDARELNERLNKKEEVPEPVAGPIVESSVTEKSPALPQADDPIVETKEVAHNVQELTPQVEAVTPLINEPEPLPTPEAQISIPESSKVEPVEGSLQSKLVEKRESTEGVLDGSKKVENKAKKDEEVFTLDPIVNKAPKLPLTDEQTAEGRKSPAVSEEKEKKKKQEKGSKEVKRSETSKEKKPSAKEVKKQTVKAPKKQTASPLSSSTEEPKKKKTGFFGKLKKLFK
InterPro domains: - IPR014756: Immunoglobulin E-set (homologous_superfamily) [8-91]
- IPR050827: CRP1/MDG1 DNA-binding & kinase subunit (family) [6-437]
- IPR032640: AMP-activated protein kinase, glycogen-binding domain (domain) [9-91]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [2-94]
Interaction partners: - Saccharopepsin
- Protein SDS24
- Protein SDS23
- 5'-AMP-activated protein kinase subunit gamma
- Maintenance of telomere capping protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0043168 (anion binding), GO:0008047 (enzyme activator activity), GO:0035091 (phosphatidylinositol binding), GO:0030695 (GTPase regulator activity), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:0080025 (phosphatidylinositol-3,5-bisphosphate binding), GO:0005096 (GTPase activator activity), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding), GO:0010314 (phosphatidylinositol-5-phosphate binding), GO:0070273 (phosphatidylinositol-4-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0051049 (regulation of transport), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0030100 (regulation of endocytosis), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0007005 (mitochondrion organization), GO:0007029 (endoplasmic reticulum organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0032126 (eisosome), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)