Protein: Probable actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC) (P58798)
Organism: Caenorhabditis elegans
Function: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Sequence: MSATLQPYLEAVRHTLQAALCLEQFSSQVVERHNKPEVEVQTSKELLMTPVVVARNKQERVLIEPSVNSVRISIAIKQSDEIEKILCHKFTRFMCQRADNFFVLRRKPLPGYDISFLITASHTEAMFKHKLVDFLLHFMQEIDKEISEMKLSLNARARVSAEEFLKRFN
InterPro domains: - IPR034666: Arp2/3 complex subunit 2/4 (homologous_superfamily) [1-168]
- IPR008384: Actin-related protein 2/3 complex subunit 4 (family) [1-169]
Interaction partners: - Probable actin-related protein 2/3 complex subunit 3
- Actin-related protein 2
- Actin-related protein 2/3 complex subunit
- Actin-related protein 3
- Probable actin-related protein 2/3 complex subunit 2
- Actin-related protein 2/3 complex subunit 5
- Probable actin-related protein 2/3 complex subunit 5
- CRIB domain-containing protein
- SPIN90/Ldb17 leucine-rich domain-containing protein
- Structure-specific endonuclease subunit SLX1 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0050896 (response to stimulus), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0007155 (cell adhesion), GO:0000902 (cell morphogenesis), GO:0033627 (cell adhesion mediated by integrin), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0009611 (response to wounding), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0042060 (wound healing), GO:0022604 (regulation of cell morphogenesis), GO:0030030 (cell projection organization), GO:0030866 (cortical actin cytoskeleton organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0008360 (regulation of cell shape), GO:0007010 (cytoskeleton organization), GO:0030031 (cell projection assembly), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031252 (cell leading edge), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005885 (Arp2/3 protein complex), GO:0005905 (clathrin-coated pit), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098858 (actin-based cell projection), GO:0030139 (endocytic vesicle), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031143 (pseudopodium), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0012506 (vesicle membrane), GO:0030863 (cortical cytoskeleton), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0030666 (endocytic vesicle membrane), GO:0030175 (filopodium), GO:0030864 (cortical actin cytoskeleton), GO:0097708 (intracellular vesicle), GO:0005856 (cytoskeleton), GO:0045335 (phagocytic vesicle), GO:0030670 (phagocytic vesicle membrane), GO:0015629 (actin cytoskeleton)