Protein: Protein ATP1B4 (X,K-ATPase subunit beta-m) (X/potassium-transporting ATPase subunit beta-m) (Q9R193)
Organism: Rattus norvegicus (Rat)
Function: May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
Subcellular location: Nucleus inner membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Detected in nuclear envelops. {ECO:0000250}.
Sequence: MRRQLRSRRAPAFPYGYRYRLDDQDEMNHNYLADEEEEAEEEAQVMMVPGLEEEEEEEEGKEEEEEREEEEGQGQSTGNAWWRKLQIVNEYLWDPEKRMSLARTGQSRSLILVIYFFFYASLAAVITLFIYMLFLAISPYMPTFTEQVKPPGVMIRPFAHSLNFNFNVSEPETWQRYVISLNGFLQGYNDSLQEEMNIDCPPGQYFIQDGDEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPEFGDPVKVSCKVQKGDENDIRSINYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQEVPVQCQLKGKGIVNDVINDRFVGRIIFTLNIET
InterPro domains: - IPR038702: Sodium/potassium-transporting ATPase subunit beta superfamily (homologous_superfamily) [83-356]
- IPR000402: Sodium/potassium-transporting ATPase subunit beta (family) [72-355]
Interaction partners: - Sodium/potassium-transporting ATPase subunit gamma
- Sodium/potassium-transporting ATPase subunit alpha-2
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha-4
- Sodium/potassium-transporting ATPase subunit alpha-3
- SNW domain-containing protein 1
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit beta-3
- Sodium/potassium-transporting ATPase subunit beta-1
- Phospholemman
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0140352 (export from cell), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0003008 (system process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0045597 (positive regulation of cell differentiation), GO:0010035 (response to inorganic substance), GO:2000026 (regulation of multicellular organismal development), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0032940 (secretion by cell), GO:1901700 (response to oxygen-containing compound), GO:0098771 (inorganic ion homeostasis), GO:0050877 (nervous system process), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0051592 (response to calcium ion), GO:0055080 (monoatomic cation homeostasis), GO:0071241 (cellular response to inorganic substance), GO:0003341 (cilium movement), GO:1902075 (cellular response to salt), GO:0046903 (secretion), GO:0014070 (response to organic cyclic compound), GO:0006873 (intracellular monoatomic ion homeostasis), GO:1901701 (cellular response to oxygen-containing compound), GO:0006811 (monoatomic ion transport), GO:0055074 (calcium ion homeostasis), GO:0071248 (cellular response to metal ion), GO:0006812 (monoatomic cation transport), GO:0071277 (cellular response to calcium ion), GO:0006874 (intracellular calcium ion homeostasis), GO:0006816 (calcium ion transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005637 (nuclear inner membrane), GO:0005634 (nucleus)