Protein: Eukaryotic translation initiation factor 2A (eIF-2A) (Q19052)
Organism: Caenorhabditis elegans
Function: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
Sequence: MGDNLVYAVRSSEGFYLKRGLGKDAVTVFEQNKTSRDVACNVFAYSNNGQLFAYCDNQVTRVFEIATNKEILCVELKRTRKILFSPKDNFLLTFEPWAVYGPKTAENQKPEPNVRVYSLADGKHVSTFSAPKEASWEPQFSDDESLAARMVGSEVFFYTNMSFDRYDHKLVEKGATNFALSPGPAPNHVAVYVPAVGSTPARVRVHRVSESFPVVGNRTFFKSDKAVMTWNQRGQSLLILASVEVDKTNQSYYGEQSLYLINIQSGESVVVPLEKKGPIYAAKWNPNGREFAVCYGYMPAKVTFYNPRGVPIFDTIEGPRNDVFYNAFGNIVLICGFGNIAKGKMEFWDVETKKEIISIEVPNTTLFDWAPDGQHFVTCTTAPRLRIDNSYRFWHYTGRMLAETHFESPKELWEVRWRPMTGYNKFAIKELTKTDKMAAGLPIRKKDASHPLNNVPAGAVRQAGAYIPPHLRKPLGGGGSAGPPSAAAPTPGNQNQRPAQPRANGNGNAPQPFRPQQSEQERKAFQLKKKVEEIKVLKQRVANGDQLQPNQMEKIQRENEYLSELSKLTI
InterPro domains: - IPR011387: Translation initiation factor 2A (family) [1-570]
- IPR013979: Translation initiation factor, beta propellor-like domain (domain) [218-415]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [113-432]
Interaction partners: - Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 2-alpha kinase gcn-2
- Eukaryotic translation initiation factor 5B
- BZIP domain-containing protein.
- Small ribosomal subunit protein uS19
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:0090079 (translation regulator activity, nucleic acid binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0008135 (translation factor activity, RNA binding), GO:0003743 (translation initiation factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0018992 (germ-line sex determination), GO:0009790 (embryo development), GO:0009994 (oocyte differentiation), GO:0007283 (spermatogenesis), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:0009792 (embryo development ending in birth or egg hatching)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)