Protein: Rho-type guanine nucleotide exchange factor, isoform H (M9PBE8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell projection, lamellipodium {ECO:0000256|ARBA:ARBA00004510}.
Sequence: MDQPLVVQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLTETIRPPEEIQEYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDLLIQIEECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQGAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCSATRRQKELELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADHRDRYFVLFPQTLLFLSVSQRMSAFIYEGKLPLTGIIVNRLEDTDALKNAFEISSPLIDRIVAVCQGPNEANKWVELLNANNPSLPMGIKRQLSNLSNSSLGHLNAAHLSQHLDSRGYCTRFSLCAYYSSPPCHVRPLRVTLPPSNYPATAPYANLSAHFARLVKGGGLRSAIVKMLLYPQARQSIDLKRIALRKRRCHKASAKLKDLNTNQDSGQSELERQDAIELPTDSESYDDDFEDDFLHSCDSDPFEYVQFYQNKRNDSMCNSTGTFVDHGTGARRHCSSINLIKLDSADTDEVLALNELKKESLVIGSRALRALARKSTTRNSSVHTSTATLELGVGGSITNCVEEEPILKVKPSFSLQQQSSDASSIFAARLGGAFTACENLASMPDDLSRESSIQEPPTPLPASPTERHSMPTIFVGNRFNHSKNTEVYVPTWRDRQEMQNQSVDAKQDEELHSSSIDLPAACLSAPDKLQAELLYNYDEILEKPLQLHRELTPFPGHNLNSDKRVSHKSDSPSTGNAKTDPNLATRSSSTTELCIDTTSKKRTTPSERSRDSIRRCISYQFLQMSNRPPPPPPPRRDPDLHLDTKCRCCENSQCPSPRSSDSGMAGSCTITSPDPPNPESYFPMEAAGHDMLDNVEPERFDVCGMFREKFLTPEATQDVVDLSEEQPQLSDEPTTPTNRKEEPTCITSAQVQVNTRSIFLPSSSSMDETNRNVPANNILFSSSSADQLEPQATFRSGMYAHWWKKERLPPEVVRGIAHAYNKSLPSKDSKDSGSVCSSCFCSLGASGYSEGALYCSVCQNCADYYNGSVTSTTNTTTTTSSASCPLCSEDEGMIAPTHDSSSLDCPICNGRIASGAEEGKQSEMDRRPGNLRIPVEWYPVYLAGGVCSVHVLRLIVL
InterPro domains: - IPR000219: Dbl homology domain (domain) [78-252]
- IPR001849: Pleckstrin homology domain (domain) [274-377]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [5-63]
- IPR001452: SH3 domain (domain) [2-61]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [68-263]
- IPR046376: RhoGEF 6/7, PH domain (domain) [281-376]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [260-376]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060090 (molecular adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0065008 (regulation of biological quality), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0050793 (regulation of developmental process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048584 (positive regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0050803 (regulation of synapse structure or activity), GO:0046620 (regulation of organ growth), GO:0009966 (regulation of signal transduction), GO:0051128 (regulation of cellular component organization), GO:0010646 (regulation of cell communication), GO:0048640 (negative regulation of developmental growth), GO:0046621 (negative regulation of organ growth), GO:0048638 (regulation of developmental growth), GO:1902533 (positive regulation of intracellular signal transduction), GO:0050807 (regulation of synapse organization), GO:1902531 (regulation of intracellular signal transduction), GO:0035332 (positive regulation of hippo signaling), GO:0035330 (regulation of hippo signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0098975 (postsynapse of neuromuscular junction), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0097482 (muscle cell postsynaptic specialization), GO:0031594 (neuromuscular junction)