Protein: Androgen-induced gene 1 protein (AIG-1) (Fatty acid esters of hydroxy fatty acids hydrolase AIG1) (FAHFA hydrolase AIG1) (EC 3.1.-.-) (Q9NVV5)
Organism: Homo sapiens (Human)
Function: Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27018888}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MALVPCQVLRMAILLSYCSILCNYKAIEMPSHQTYGGSWKFLTFIDLVIQAVFFGICVLTDLSSLLTRGSGNQEQERQLKKLISLRDWMLAVLAFPVGVFVVAVFWIIYAYDREMIYPKLLDNFIPGWLNHGMHTTVLPFILIEMRTSHHQYPSRSSGLTAICTFSVGYILWVCWVHHVTGMWVYPFLEHIGPGARIIFFGSTTILMNFLYLLGEVLNNYIWDTQKSMEEEKEKPKLE
InterPro domains: - IPR006838: ADTRP/AIG1 (family) [1-234]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0031647 (regulation of protein stability), GO:0031324 (negative regulation of cellular metabolic process), GO:0009894 (regulation of catabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0030097 (hemopoiesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043488 (regulation of mRNA stability), GO:0031330 (negative regulation of cellular catabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0048732 (gland development), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0048863 (stem cell differentiation), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0050821 (protein stabilization), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0060429 (epithelium development), GO:0031329 (regulation of cellular catabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:1902373 (negative regulation of mRNA catabolic process), GO:0014033 (neural crest cell differentiation), GO:0061013 (regulation of mRNA catabolic process), GO:1903312 (negative regulation of mRNA metabolic process), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0048255 (mRNA stabilization), GO:1903131 (mononuclear cell differentiation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:1903311 (regulation of mRNA metabolic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0014902 (myotube differentiation), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0098857 (membrane microdomain), GO:0005886 (plasma membrane), GO:0044853 (plasma membrane raft), GO:0045121 (membrane raft), GO:0005901 (caveola)