Protein: Histone chaperone RTT106 (Q6FRJ6)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
Function: Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity)
Subcellular location: Nucleus. Chromosome
Sequence: MSSFDFLNELPKELQNKIRNITRALPSSLEVFQELYNYGLSHSDNIEKKRKVTSNGVIDEQNIIFSLKNVSVLSPIRKKLDLVLHLSSIDHKPQLSLVKNGVSEFSISNLKDNVKMGTFLPVPEKPNLLYLFVQLKKVNDKDQDPILLTMNKENVLTEFKSMGLIGQEVDDFNKCTEYIRKQAILTGFKIANPFNPSVEQPVPSFHVECHRGTKEGTLYFLPEIIIFGFKKPILVFESSNIESISYSSITRLTFNVTLIKKVDDGYGTKFEFSMIDQTEYSKIDDYVKLKQVKDESMSEELKAKTANKNKQQNNTSDQPSALQEATKQMETEGNINEIPFDSEDDEEADGNFEDNSDLSDGSEVEEEDNEEENEEDEEADGGDYAEEDFEEDEIIQEQANPAVNQLISKTTPINKNSSNAGLFDFPIETPSFDIPIELEDNEDDEEGSGVEYD
InterPro domains: - IPR044891: Histone chaperone Rtt106, N-terminal domain superfamily (homologous_superfamily) [1-60]
- IPR040770: Rtt106, pleckstrin homology domain (domain) [58-193]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [196-291]
- IPR013719: Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain (domain) [204-297]
- IPR050454: RTT106/SSRP1 Histone Chaperone/FACT Complex (family) [61-390]
- IPR040993: Histone chaperone Rtt106, N-terminal domain (domain) [5-58]
Interaction partners: - Histone H3
- Candida glabrata strain CBS138 chromosome J complete sequence
- Candida glabrata strain CBS138 chromosome K complete sequence
- Candida glabrata strain CBS138 chromosome F complete sequence
- FACT complex subunit SPT16
- Histone chaperone ASF1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0042393 (histone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)