Protein: Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) (O35147)
Organism: Rattus norvegicus (Rat)
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Subcellular location: Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}.
Sequence: MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMFQIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGAGTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFEGSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ
InterPro domains: - IPR018868: Bcl2-associated agonist of cell death (family) [1-205]
Interaction partners: - Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- RAC-alpha serine/threonine-protein kinase
- 14-3-3 protein zeta/delta
- 14-3-3 protein theta
- 14-3-3 protein beta/alpha
- 14-3-3 protein epsilon
- RAF proto-oncogene serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- RAC-gamma serine/threonine-protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0019209 (kinase activator activity), GO:0019900 (kinase binding), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity), GO:0019901 (protein kinase binding), GO:0043539 (protein serine/threonine kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007568 (aging), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0001666 (response to hypoxia), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0010941 (regulation of cell death), GO:0009611 (response to wounding), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0070482 (response to oxygen levels), GO:0009617 (response to bacterium), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0009896 (positive regulation of catabolic process), GO:1901216 (positive regulation of neuron death), GO:0071456 (cellular response to hypoxia), GO:0034097 (response to cytokine), GO:0032496 (response to lipopolysaccharide), GO:0071453 (cellular response to oxygen levels), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0036293 (response to decreased oxygen levels), GO:0006915 (apoptotic process), GO:0033043 (regulation of organelle organization), GO:1901214 (regulation of neuron death), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0010638 (positive regulation of organelle organization), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0036294 (cellular response to decreased oxygen levels), GO:0090200 (positive regulation of release of cytochrome c from mitochondria), GO:0010821 (regulation of mitochondrion organization), GO:0010822 (positive regulation of mitochondrion organization), GO:0071345 (cellular response to cytokine stimulus), GO:0043525 (positive regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)