Protein: Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2) (Q9Y6Y9)
Organism: Homo sapiens (Human)
Function: Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11593030, ECO:0000305|PubMed:11274165}. Secreted {ECO:0000269|PubMed:11593030}. Note=Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581). {ECO:0000269|PubMed:10359581, ECO:0000269|PubMed:11593030}.
Sequence: MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
InterPro domains: - IPR014756: Immunoglobulin E-set (homologous_superfamily) [32-155]
- IPR039217: Lymphocyte antigen 96 (family) [1-160]
- IPR003172: MD-2-related lipid-recognition domain (domain) [32-153]
Interaction partners: - Myeloid differentiation primary response protein MyD88
- Toll-like receptor 4
- Toll-like receptor 2
- Lymphocyte antigen 86
- Toll/interleukin-1 receptor domain-containing adapter protein
- Lipopolysaccharide-binding protein
- Monocyte differentiation antigen CD14
- High mobility group protein B1
- CD44 antigen
- Toll-like receptor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0032101 (regulation of response to external stimulus), GO:0010647 (positive regulation of cell communication), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0010646 (regulation of cell communication), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009966 (regulation of signal transduction), GO:0031664 (regulation of lipopolysaccharide-mediated signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0034774 (secretory granule lumen), GO:0005774 (vacuolar membrane), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:0097708 (intracellular vesicle), GO:0098852 (lytic vacuole membrane), GO:0005766 (primary lysosome), GO:0005765 (lysosomal membrane)