Protein: Surfeit locus protein 4 homolog (Q18864)
Organism: Caenorhabditis elegans
Function: Endoplasmic reticulum cargo receptor that mediates the export of the yolk proteins from intestinal cells by recruiting cargos into COPII vesicles to facilitate their secretion. Required for the endoplasmic reticulum export of the yolk protein vit-2, which is synthesized as a lipoprotein complex, from intestinal cells. Involved in endoplasmic reticulum exit sites (ERES) organization.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29643117}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localizes at endoplasmic reticulum exit sites (ERES). {ECO:0000269|PubMed:29643117}.
Sequence: MNQFRAPGGQNEMLAKAEDAAEDFFRKTRTYLPHIARLCLVSTFLEDGIRMYFQWDDQKQFMQESWSCGWFIATLFVIYNFFGQFIPVLMIMLRKKVLVACGILASIVILQTIAYHILWDLKFLARNIAVGGGLLLLLAETQEEKASLFAGVPTMGDSNKPKSYMLLAGRVLLIFMFMSLMHFEMSFMQVLEIVVGFALITLVSIGYKTKLSAIVLVIWLFGLNLWLNAWWTIPSDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKRW
InterPro domains: - IPR002995: Surfeit locus 4 (family) [11-277]
- IPR045214: Surfeit locus 1/4 (family) [15-250]
Interaction partners: - GOLD domain-containing protein
- ERGIC-53-like protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- EF-hand domain-containing protein
- Golgi SNAP receptor complex member 1
- Uncharacterized protein
- Suppressor/enhancer of lin-12 protein 9
- Transmembrane 9 superfamily member
- Peptidase M20 dimerisation domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0038024 (cargo receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0140352 (export from cell), GO:0045927 (positive regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:0040008 (regulation of growth), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0048638 (regulation of developmental growth), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0046903 (secretion), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0033365 (protein localization to organelle), GO:0071692 (protein localization to extracellular region)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)