Protein: Transcription factor aptf-2 (G2HK15)
Organism: Caenorhabditis elegans
Function: Sequence-specific DNA-binding protein that interacts with enhancer elements to regulate transcription of selected genes (By similarity). Required for neuroblast and epidermal morphogenesis, perhaps acting in cooperation with transcription factor aptf-4.
Subcellular location: Nucleus {ECO:0000269|PubMed:27176626}. Cytoplasm {ECO:0000269|PubMed:27176626}. Note=Localized to both cytoplasm and nucleus in most cells, but significant nuclear enrichment in neuroblasts and epidermal cells in AB lineage during ventral cleft closure and in epidermal cells in C lineage preceding dorsal intercalation. {ECO:0000269|PubMed:27176626}.
Sequence: MDIQMFTTLNSTVPTEPVVGPVEPTVPTVPATKETGPSSSAECSTQPAVAEQEDNSLLAQLLKGKITSDDAKLQPPRGPFEYAPMLSEEAQFAIKLAGLLNPNPVTEQDPSTFKPPPKMSNNVRKNINLTPVIENAVPSGFELESPKDQAFDVVHGRLSMGQNQTCYFVTVEEMRRRLQSPEKLNSSSIACNLKRPKLKNGGELMRAQLRDHGIKVQLNAKQKAFPNKVIALVEAEAVHLGLDLGTAVRDDYPVQDIIQEVAHEALADEDADLDALMNDKDFTECMSALESVFTSVVPPITGIEPKPSNNMRLNNGMETFSSASHGLGIVSQRVWLPQLTAIGNGVASELRRLTETPTESKPEELKA
InterPro domains: - IPR004979: Transcription factor AP-2 (family) [129-361]
- IPR013854: Transcription factor AP-2, C-terminal (domain) [151-344]
Interaction partners: - Transcription factor aptf-4
- Transcription factor AP-2 C-terminal domain-containing protein
- Nuclear hormone receptor family member nhr-125
- Nuclear Hormone Receptor family
- HMG box domain-containing protein
- Nuclear Hormone Receptor family
- Nuclear receptor domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0008340 (determination of adult lifespan), GO:0032259 (methylation), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0009056 (catabolic process), GO:0009791 (post-embryonic development), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:0046660 (female sex differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0010171 (body morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0048608 (reproductive structure development), GO:0043414 (macromolecule methylation), GO:0045137 (development of primary sexual characteristics), GO:0043170 (macromolecule metabolic process), GO:0040012 (regulation of locomotion), GO:0035262 (gonad morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0035112 (genitalia morphogenesis), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0002164 (larval development), GO:0007548 (sex differentiation), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0007530 (sex determination), GO:0061458 (reproductive system development), GO:1901565 (organonitrogen compound catabolic process), GO:0006518 (peptide metabolic process), GO:0006479 (protein methylation), GO:0030163 (protein catabolic process), GO:0008406 (gonad development), GO:0010468 (regulation of gene expression), GO:0009057 (macromolecule catabolic process), GO:0048568 (embryonic organ development), GO:0044265 (cellular macromolecule catabolic process), GO:0048569 (post-embryonic animal organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0002119 (nematode larval development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0008585 (female gonad development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0040024 (dauer larval development), GO:0040025 (vulval development), GO:0016571 (histone methylation), GO:0010498 (proteasomal protein catabolic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0034968 (histone lysine methylation), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0098796 (membrane protein complex), GO:0055120 (striated muscle dense body), GO:1902494 (catalytic complex)