Protein: C-X-C chemokine receptor type 2 (High affinity interleukin-8 receptor B) (C9J1J7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGL
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [65-172]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [50-171]
- IPR000174: CXC chemokine receptor 1/2 (family) [35-133]
- IPR050119: C-C chemokine receptor type 1-9-like (family) [21-171]
- IPR000057: CXC chemokine receptor 2 (family) [5-47]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0019955 (cytokine binding), GO:0140375 (immune receptor activity), GO:0019956 (chemokine binding), GO:0004896 (cytokine receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0004950 (chemokine receptor activity), GO:0001637 (G protein-coupled chemoattractant receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0042330 (taxis), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:2000145 (regulation of cell motility), GO:0035556 (intracellular signal transduction), GO:0002685 (regulation of leukocyte migration), GO:0050920 (regulation of chemotaxis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:0098542 (defense response to other organism), GO:0016477 (cell migration), GO:0006935 (chemotaxis), GO:0050921 (positive regulation of chemotaxis), GO:1905523 (positive regulation of macrophage migration), GO:1905521 (regulation of macrophage migration), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:1902622 (regulation of neutrophil migration), GO:0060326 (cell chemotaxis), GO:0006954 (inflammatory response), GO:0002688 (regulation of leukocyte chemotaxis), GO:0071675 (regulation of mononuclear cell migration), GO:0030593 (neutrophil chemotaxis), GO:0071622 (regulation of granulocyte chemotaxis), GO:0010758 (regulation of macrophage chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005654 (nucleoplasm), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)