Protein: Coiled-coil domain-containing protein 68 (Cutaneous T-cell lymphoma-associated antigen se57-1) (CTCL-associated antigen se57-1) (Q9H2F9)
Organism: Homo sapiens (Human)
Function: Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28422092}. Note=Localizes to the subdistal appendages of centrioles (PubMed:28422092). {ECO:0000269|PubMed:28422092}.
Sequence: MTTVTVTTEIPPRDKMEDNSALYESTSAHIIEETEYVKKIRTTLQKIRTQMFKDEIRHDSTNHKLDAKHCGNLQQGSDSEMDPSCCSLDLLMKKIKGKDLQLLEMNKENEVLKIKLQASREAGAAALRNVAQRLFENYQTQSEEVRKKQEDSKQLLQVNKLEKEQKLKQHVENLNQVAEKLEEKHSQITELENLVQRMEKEKRTLLERKLSLENKLLQLKSSATYGKSCQDLQREISILQEQISHLQFVIHSQHQNLRSVIQEMEGLKNNLKEQDKRIENLREKVNILEAQNKELKTQVALSSETPRTKVSKAVSTSELKTEGVSPYLMLIRLRK
InterPro domains: - IPR051375: Tuftelin/GRINL1A/MYZAP/CCD68 (family) [1-307]
Interaction partners: - Ninein
- Coiled-coil domain-containing protein 120
- Centrosomal protein of 170 kDa
- Centrosomal protein of 128 kDa
- Melanoma inhibitory activity protein 2
- cTAGE family member 2
- Centriolin
- Outer dense fiber protein 2
- Dynactin subunit 1
- Kinesin-like protein KIF2A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0045786 (negative regulation of cell cycle), GO:0051129 (negative regulation of cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0044087 (regulation of cellular component biogenesis), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0046599 (regulation of centriole replication), GO:0046605 (regulation of centrosome cycle), GO:1902115 (regulation of organelle assembly), GO:0010824 (regulation of centrosome duplication), GO:0010826 (negative regulation of centrosome duplication), GO:0051493 (regulation of cytoskeleton organization), GO:1902116 (negative regulation of organelle assembly), GO:0051494 (negative regulation of cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)