Protein: Transmembrane phosphatase with tensin homology (Tyrosine-protein phosphatase TPTE (EC 3.1.3.48)) (Q4V9E4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell projection {ECO:0000256|ARBA:ARBA00004316}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MTSVHFNPGLDSKEVNGNSVKEEAEVQIDDGKEETKDPDTMYHQVRKKITPFVMSFGFRVFGLVLIILDIIMVIVDLSLSEKSRDVGGAPETVSLVISFFFLIDVLLRVYVEGFKVYFSSKLNIVDACIVVITLVVTMIYAFSDFSGASLIPRVVTFLRSLRILILVRIFRLASQKRELEKVTRRMVSENKRRYQKDGFDLDLTYVTERVIAMSFPSSGKQALYRNPIREVVRFLDTKHMDHYKVFNLCSEKGYDPKFFHYRVERVMIDDHNVPSLDDMLRYTACVRDWMAADSRNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQESLDYFGERRTDKSMSSKFQGVETPSQSRYVGYYEIMKNQYNRQLPPRKSLKIKSIRIHSIAGVGKGNGSDLKLKIIVKHELVFQCVCAKQHNCTVFPDTGSNAVVISLQDGPIVTGDVKVMFESSAGLPKGYEDCPFYFWFNTSFVENYRLFLSREELDNPHKPKTWDIYKEDFGVTLSFTEP
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [179-371]
- IPR035892: C2 domain superfamily (homologous_superfamily) [374-510]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [277-337]
- IPR014020: Tensin phosphatase, C2 domain (domain) [373-511]
- IPR029023: Tensin-type phosphatase domain (domain) [192-368]
- IPR051281: Dual-specificity lipid and protein phosphatase (family) [172-510]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [47-178]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [259-365]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [300-310]
- IPR045102: TPTE, protein tyrosine phosphatase-like catalytic domain (domain) [188-364]
- IPR005821: Ion transport domain (domain) [58-181]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016787 (hydrolase activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0005216 (monoatomic ion channel activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0015267 (channel activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0034594 (phosphatidylinositol trisphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0030258 (lipid modification), GO:0006796 (phosphate-containing compound metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006650 (glycerophospholipid metabolic process), GO:0016311 (dephosphorylation), GO:0046839 (phospholipid dephosphorylation), GO:0046856 (phosphatidylinositol dephosphorylation), GO:0046488 (phosphatidylinositol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)