Protein: Lymphotoxin-alpha (Q1L8A5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo
Subcellular location: Membrane; Single- pass type II membrane protein
Sequence: MKLESRAFLDVEEGELPLPLVIVSRRKAGSSKSGVWRVFGIILAVGLCAAAAVCFTLHKTQGNQQDGSVLRLTLRDRISQGNFTSKAAIHLTGGYNSESKTLDWRDDQDQAFSSGGLKLVNREIIIPDDGIYFVYSQVSLHISCTSELTEEQVLMSHAVMRFSESYGGKKPLFSAIRSICTQEPESENLWYNTIYLGAAFHLREGDRLGTDTTTALLPMVENDNGKTFFGVFGL
InterPro domains: - IPR006053: Tumour necrosis factor (family) [104-213]
- IPR002960: Lymphotoxin-alpha (family) [96-166]
- IPR006052: Tumour necrosis factor domain (domain) [87-234]
- IPR008983: Tumour necrosis factor-like domain superfamily (homologous_superfamily) [76-234]
Interaction partners: - Nuclear factor NF-kappa-B p105 subunit isoform X1
- Transcription factor Jun
- Tumor necrosis factor receptor superfamily member 1B precursor
- Transcription factor p65
- CD40 molecule, TNF receptor superfamily member 5
- Interferon gamma related precursor
- Interleukin family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0032813 (tumor necrosis factor receptor superfamily binding), GO:0005164 (tumor necrosis factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0007586 (digestion), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0006950 (response to stress), GO:0061919 (process utilizing autophagic mechanism), GO:0048871 (multicellular organismal-level homeostasis), GO:0051707 (response to other organism), GO:0009056 (catabolic process), GO:0003008 (system process), GO:0043207 (response to external biotic stimulus), GO:0022600 (digestive system process), GO:1901698 (response to nitrogen compound), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0009617 (response to bacterium), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0001894 (tissue homeostasis), GO:0042246 (tissue regeneration), GO:0009615 (response to virus), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0060249 (anatomical structure homeostasis), GO:0006914 (autophagy), GO:0098542 (defense response to other organism), GO:0046685 (response to arsenic-containing substance), GO:0032496 (response to lipopolysaccharide), GO:0006954 (inflammatory response), GO:0033993 (response to lipid), GO:0042742 (defense response to bacterium), GO:0010669 (epithelial structure maintenance), GO:0030277 (maintenance of gastrointestinal epithelium), GO:0048732 (gland development), GO:0043331 (response to dsRNA), GO:0002237 (response to molecule of bacterial origin), GO:0014070 (response to organic cyclic compound), GO:0061008 (hepaticobiliary system development), GO:0031101 (fin regeneration), GO:0060729 (intestinal epithelial structure maintenance), GO:0001889 (liver development), GO:0043330 (response to exogenous dsRNA)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)