Protein: Rap guanine nucleotide exchange factor 6 (E9PCH4)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFDSSVKRRNEDISVSDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRNNTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHAVHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
InterPro domains: - IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [899-1187]
- IPR036034: PDZ superfamily (homologous_superfamily) [570-664]
- IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [906-1188]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [60-435]
- IPR000159: Ras-associating domain (domain) [799-885]
- IPR000651: Ras-like guanine nucleotide exchange factor, N-terminal (domain) [462-576]
- IPR000595: Cyclic nucleotide-binding domain (domain) [330-448]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [430-1196]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [73-432]
- IPR001478: PDZ domain (domain) [580-662]
Interaction partners: - Rap guanine nucleotide exchange factor 6
- Tyrosine-protein phosphatase non-receptor type 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0030742 (GTP-dependent protein binding), GO:0005543 (phospholipid binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0043168 (anion binding), GO:0019899 (enzyme binding), GO:0030695 (GTPase regulator activity), GO:0051020 (GTPase binding), GO:0070300 (phosphatidic acid binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0065007 (biological regulation), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0044085 (cellular component biogenesis), GO:0051668 (localization within membrane), GO:0072657 (protein localization to membrane), GO:0030030 (cell projection organization), GO:0008104 (protein localization), GO:0043085 (positive regulation of catalytic activity), GO:0051336 (regulation of hydrolase activity), GO:0022607 (cellular component assembly), GO:0030031 (cell projection assembly), GO:0043087 (regulation of GTPase activity), GO:0051345 (positive regulation of hydrolase activity), GO:0120036 (plasma membrane bounded cell projection organization), GO:1990778 (protein localization to cell periphery), GO:0072659 (protein localization to plasma membrane), GO:0032528 (microvillus organization), GO:0043547 (positive regulation of GTPase activity), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097708 (intracellular vesicle), GO:0015630 (microtubule cytoskeleton)