wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) (Citrate synthase) (EC 2.3.3.16) (Q937N9)
Organism: Cupriavidus necator (Alcaligenes eutrophus) (Ralstonia eutropha)
Function: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower efficiency.
Sequence: MSEAQPLVTPKPKKSVALSGVTAGNTALCTVGRTGNDLHYRGYDILDIAETCEFEEIAHLLVHGKLPTKSELAAYKAKLKSLRGLPANVKAALEWVPASAHPMDVMRTGVSVLGTVLPEKEDHNTPGARDIADRLMASLGSMLLYWYHYSHNGRRIEVETDDDSIGGHFLHLLHGEKPSALWERAMNTSLNLYAEHEFNASTFTARVIAGTGSDMYSSISGAIGALRGPKHGGANEVAFEIQKRYDNPDEAQADITRRVENKEVVIGFGHPVYTTGDPRNQVIKEVAKKLSKDAGSMKMFDIAEALETVMWDIKKMFPNLDWFSAVSYHMMGVPTAMFTALFVIARTSGWAAHIIEQRIDNKIIRQSANYTGPENLKFVPLKDRK
InterPro domains: - IPR011278: 2-methylcitrate synthase/citrate synthase type I (family) [17-384]
- IPR016143: Citrate synthase-like, small alpha subdomain (homologous_superfamily) [233-334]
- IPR016142: Citrate synthase-like, large alpha subdomain (homologous_superfamily) [27-356]
- IPR019810: Citrate synthase active site (active_site) [267-279]
- IPR036969: Citrate synthase superfamily (homologous_superfamily) [18-377]
- IPR024176: Citrate synthase, bacterial-type (family) [11-385]
- IPR002020: Citrate synthase (family) [18-383]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0046912 (acyltransferase activity, acyl groups converted into alkyl on transfer), GO:0036440 (citrate synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0019541 (propionate metabolic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0019679 (propionate metabolic process, methylcitrate cycle), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046459 (short-chain fatty acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: cAMP-dependent protein kinase type II-alpha regulatory subunit (A9C3T0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MSIEIPVGLTELLQGYTVEVLRQRPPDLVEFAVQYFTRLRDTRSQDGSGAAAKTGGKGVMFDGEPMQTESNGDEDDEDDDSDFEPPPPSRFNRRVSVCAEAFNPDDDEEDSEPRVVHPKTDEQRCRLQEACKDILLFKALDQEQFSEVLDAMFEVLVQPQDHVIDQGDDGDNFYVIERGVYDIVVQKDGVGCCVGQYNNKGSFGELALMYNTPRAATIIAKDEGALWGLDRATFRRLIVKNNAKKRRMYECFIESIPLLKSLELSERMKIVDVLGVKTFQDGERIIMQGDKADCFYIVESGEVKIMMKSKTKADRQDNAEVEIARCSRGQYFGELALVTNKPRAASAYAIGDVKCLVIDIQAFERLLGPCKEIMKRNIAHYEEQLVALFGSSVDLRD
InterPro domains: - IPR050503: cAMP-dependent protein kinase regulatory subunit-like (family) [17-386]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [96-391]
- IPR012198: cAMP-dependent protein kinase regulatory subunit (family) [5-394]
- IPR000595: Cyclic nucleotide-binding domain (domain) [136-384]
- IPR018488: Cyclic nucleotide-binding, conserved site (conserved_site) [163-349]
- IPR003117: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain (domain) [7-44]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [117-389]
Interaction partners: - cAMP-dependent protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- Protein kinase, cAMP-dependent, regulatory, type I, alpha b.
- cAMP-dependent protein kinase type I-alpha regulatory subunit
- Protein kinase, cAMP-dependent, regulatory, type I, beta
- cAMP-dependent protein kinase type II regulatory subunit
- Si:ch211-272n13.7.
- Protein kinase X-linked
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Heterogeneous nuclear ribonucleoprotein L-like (Q921F4)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.
Sequence: MSSSSSSSPKEETYEEDREFESQAKRLKTEEGEIVYSAEESENRQEATPQAGSDSDSGGGDGGDGDGGSGGGGDGEEGEGGEEGDEGDGDEGGSGGDEGGSGGGPRSMPLSTEGGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFKRQALVEFENIDSAKECVTFAADVPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGDHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGSPSGSVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLPFIKYKVFDAKASAKTLSGLLEWKCKTDAVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [113-463]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [125-585]
- IPR006536: HnRNP-L/PTB (family) [123-590]
- IPR021790: PTBP1-like, RNA recognition motif 2 (domain) [214-292]
- IPR034986: hnRPLL, RNA recognition motif 2 (domain) [214-309]
- IPR034987: hnRPLL, RNA recognition motif 4 (domain) [501-585]
- IPR034985: hnRPLL, RNA recognition motif 1 (domain) [122-205]
- IPR000504: RNA recognition motif domain (domain) [125-458]
- IPR034983: hnRPLL, RNA recognition motif 3 (domain) [385-458]
Interaction partners: - SUMO-conjugating enzyme UBC9
- Histone-lysine N-methyltransferase SETD2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing), GO:1903311 (regulation of mRNA metabolic process), GO:0050684 (regulation of mRNA processing), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0045120 (pronucleus)
Protein: Bet1-like SNARE 1-1 (AtBET11) (Bet1/Sft1-like SNARE 14a) (AtBS14a) (Q9M2J9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE associated with ER-derived vesicles (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
Sequence: MNPRREPRGGRSSLFDGIEEGGIRAASSYSHEINEHENERALEGLQDRVILLKRLSGDINEEVDTHNRMLDRMGNDMDSSRGFLSGTMDRFKTVFETKSSRRMLTLVASFVGLFLVIYYLTR
InterPro domains: - IPR000727: Target SNARE coiled-coil homology domain (domain) [25-94]
- IPR039899: BET1, SNARE domain (domain) [35-93]
Interaction partners: - Syntaxin-31
- Membrin-11
- Syntaxin-32
- Membrin-12
- 25.3 kDa vesicle transport protein SEC22-1
- SNARE-like superfamily protein
- Golgi SNAP receptor complex member 1-1
- Golgi SNAP receptor complex member 1-2
- VAMP-like protein YKT62
- VAMP-like protein YKT61
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0048583 (regulation of response to stimulus), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0051651 (maintenance of location in cell), GO:0048584 (positive regulation of response to stimulus), GO:0051235 (maintenance of location), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:1901002 (positive regulation of response to salt stress), GO:0080134 (regulation of response to stress), GO:0047484 (regulation of response to osmotic stress), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055078 (sodium ion homeostasis), GO:1901000 (regulation of response to salt stress), GO:0006883 (intracellular sodium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Rbp12 protein (Q26281)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: FVDNLDSSVSEDLLIALFSTMGPVKSCKIIREPGNDPYAFI
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [1-41]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [1-41]
- IPR000504: RNA recognition motif domain (domain) [1-41]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0008283 (cell population proliferation), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0036093 (germ cell proliferation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0007399 (nervous system development), GO:0007292 (female gamete generation), GO:0048477 (oogenesis), GO:0060856 (establishment of blood-brain barrier), GO:0007417 (central nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: N-acetylgalactosaminide beta-1,3-galactosyltransferase (EC 2.4.1.122) (Q9VQH6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Sequence: MGVRPNRKRLELMLMLLIGLAWGILLSELMKRTRWQNHADRLKEESSPFPSSQRSRNLRTPPTIAPSTTNPPPDILAARLFNETRVLCMVLTSPKTHHTRAIHIKRTWGRRCNKLIFMSTKADKELGSVALNVREGYSNLWPKTRAALQYVYKHHFQKYDWFLKADDDTYFIMENLRAFLHAHNFREPVYFGNKFRQHVKEGYMSGGAGYVLSKMALHRLIKLGFSNSSICTNRNYGYEDVELGRCLAGVGVVGGDSRDEQGLSRFIPFSPLHWYPQPPDWYQPLLYYTSPDNSSDCCSNTAISFHYNNAQEFYVLEYIIYKLRIFGINRELGPLPKKKASSRPMSINLQTTKEENGHIALIKMMPRKNVTTPNYRTKTTSKFKK
InterPro domains: - IPR003378: Fringe-like, glycosyltransferase domain (domain) [86-249]
- IPR026050: C1GALT1/C1GALT1-specific chaperone 1 (family) [12-330]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008378 (galactosyltransferase activity), GO:0048531 (beta-1,3-galactosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0044249 (cellular biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0009100 (glycoprotein metabolic process), GO:0009101 (glycoprotein biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0005797 (Golgi medial cisterna)
Protein: Myosin light chain 3 (Myosin alkali light chain 1, ventricular) (MLClV) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin light chain 1) (rVMLC1) (P16409)
Organism: Rattus norvegicus (Rat)
Function: Regulatory light chain of myosin. Does not bind calcium.
Sequence: MAPKKPEPKKDDAKTAAPKAAPAPAAAPAAAPEPERPKEAEFDASKIKIEFTPEQIEEFKEAFQLFDRTPKGEMKITYGQCGDVLRALGQNPTQAEVLRVLGKPKQEELNSKMMDFETFLPMLQHISKNKDTGTYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGERLTEDEVEKLMAGQEDSNGCINYEAFVKHIMAS
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [51-198]
- IPR050230: Calmodulin/Myosin light chain/Troponin C-like (family) [50-197]
- IPR002048: EF-hand domain (domain) [54-198]
Interaction partners: - Myosin-7
- Myosin-6
- Actin, alpha cardiac muscle 1
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Myosin light chain kinase 2, skeletal/cardiac muscle
- Troponin I, slow skeletal muscle
- Similar to OTTMUSP00000000621
- Myosin light chain kinase 3
- Myosin light chain 4
- Myosin-binding protein C, cardiac-type
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0008307 (structural constituent of muscle)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0003013 (circulatory system process), GO:0003015 (heart process), GO:0008015 (blood circulation), GO:0006936 (muscle contraction), GO:0006941 (striated muscle contraction), GO:0060047 (heart contraction), GO:0060048 (cardiac muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043292 (contractile fiber), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber)
Protein: Hsc70-interacting protein (Hip) (Protein FAM10A1) (Protein ST13 homolog) (Q99L47)
Organism: Mus musculus (Mouse)
Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MDPRKVSELRAFVKMCRQDPSVLHTEEMRFLREWVESMGGKVPPATHKAKSEENTKEEKRDKTTEENIKTEELSSEESDLEIDNEGVIEPDTDAPQEMGDENAEITEEMMDEANEKKGAAIEALNDGELQKAIDLFTDAIKLNPRLAILYAKRASVFVKLQKPNAAIRDCDRAIEINPDSAQPYKWRGKAHRLLGHWEEAAHDLALACKLDYDEDASAMLREVQPRAQKIAEHRRKYERKREEREIKERIERVKKAREEHERAQREEEARRQSGSQYGSFPGGFPGGMPGNFPGGMPGMGGAMPGMAGMAGMPGLNEILSDPEVLAAMQDPEVMVAFQDVAQNPSNMSKYQSNPKVMNLISKLSAKFGGQS
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [73-247]
- IPR034649: Hsp70-interacting protein, N-terminal (domain) [2-43]
- IPR041243: STI1/HOP, DP domain (domain) [317-363]
- IPR006636: Heat shock chaperonin-binding (domain) [321-360]
- IPR019734: Tetratricopeptide repeat (repeat) [113-214]
Interaction partners: - Heat shock cognate 71 kDa protein
- Heat shock 70 kDa protein 1B
- Heat shock protein HSP 90-alpha
- Heat shock protein HSP 90-beta
- DnaJ homolog subfamily B member 1
- BAG family molecular chaperone regulator 1
- Prostaglandin E synthase 3
- Heat shock 70 kDa protein 4
- BAG family molecular chaperone regulator 3
- Glycogen synthase kinase-3 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: DNA-binding protein Fis (P57902)
Organism: Pasteurella multocida (strain Pm70)
Function: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
Sequence: MLEQQRNPADALTVSVLNSQSQVTNKPLRDSVKQALRNYLSQLDGQDVNELYELVLAEVEHPMLDMVMQYTRGNQTRAATMLGINRGTLRKKLKKYGMG
InterPro domains: - IPR002197: DNA binding HTH domain, Fis-type (domain) [56-99]
- IPR005412: DNA-binding protein Fis (family) [1-99]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [8-98]
- IPR050207: Transcriptional regulatory Fis (family) [1-98]
Interaction partners: - tRNA-dihydrouridine synthase B
- cAMP-activated global transcriptional regulator CRP
- RNA-binding protein Hfq
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009987 (cellular process), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0042710 (biofilm formation), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)