Protein: CD63 antigen (Mast cell antigen AD1) (CD antigen CD63) (P28648)
Organism: Rattus norvegicus (Rat)
Function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:1634775}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:1634775}; Multi-pass membrane protein. Late endosome membrane {ECO:0000250|UniProtKB:P08962}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000250|UniProtKB:P08962}. Melanosome {ECO:0000250|UniProtKB:P08962}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P08962}. Cell surface {ECO:0000269|PubMed:1703158}. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies. {ECO:0000250|UniProtKB:P08962}.
Sequence: MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFSKSFQKQMQNYLTDNKTATILDKLQKENKCCGASNYTDWERIPGMAKDRVPDSCCINITVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEVLGIIFSCCLVKSIRSGYEVM
InterPro domains: - IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [105-202]
- IPR000301: Tetraspanin, animals (family) [1-236]
- IPR042028: CD63, extracellular domain (domain) [105-203]
- IPR018499: Tetraspanin/Peripherin (family) [10-229]
- IPR018503: Tetraspanin, conserved site (conserved_site) [61-83]
Interaction partners: - Tumor susceptibility gene 101 protein
- Integrin beta-1
- CD81 antigen
- Metalloproteinase inhibitor 1
- CD9 antigen
- Syntenin-1
- Heat shock 70 kDa protein 4
- Syntenin-2
- Lysosome-associated membrane glycoprotein 2
- CD82 antigen
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0051049 (regulation of transport), GO:0050878 (regulation of body fluid levels), GO:0051047 (positive regulation of secretion), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0007589 (body fluid secretion), GO:0071310 (cellular response to organic substance), GO:0048732 (gland development), GO:1901699 (cellular response to nitrogen compound), GO:0046903 (secretion), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:1901701 (cellular response to oxygen-containing compound), GO:0030879 (mammary gland development), GO:1901653 (cellular response to peptide), GO:0006897 (endocytosis), GO:0071375 (cellular response to peptide hormone stimulus), GO:0008645 (hexose transmembrane transport), GO:0032868 (response to insulin), GO:0006898 (receptor-mediated endocytosis), GO:0032869 (cellular response to insulin stimulus), GO:0031623 (receptor internalization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0055037 (recycling endosome), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)