Protein: BH3-interacting domain death agonist (A8ASI8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR038018}. Mitochondrion outer membrane {ECO:0000256|PIRNR:PIRNR038018}.
Sequence: MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD
InterPro domains: - IPR010479: BH3-interacting domain death agonist (family) [1-195]
- IPR036834: Bcl-2-like superfamily (homologous_superfamily) [1-195]
- IPR020728: Apoptosis regulator, Bcl-2, BH3 motif, conserved site (conserved_site) [86-100]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0032813 (tumor necrosis factor receptor superfamily binding), GO:0005123 (death receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009967 (positive regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0035556 (intracellular signal transduction), GO:0009966 (regulation of signal transduction), GO:0051130 (positive regulation of cellular component organization), GO:0051668 (localization within membrane), GO:0044089 (positive regulation of cellular component biogenesis), GO:0045184 (establishment of protein localization), GO:0070997 (neuron death), GO:0044087 (regulation of cellular component biogenesis), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0097190 (apoptotic signaling pathway), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0043254 (regulation of protein-containing complex assembly), GO:0006974 (cellular response to DNA damage stimulus), GO:0043067 (regulation of programmed cell death), GO:0042770 (signal transduction in response to DNA damage), GO:0043068 (positive regulation of programmed cell death), GO:2001235 (positive regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:0090150 (establishment of protein localization to membrane), GO:0051402 (neuron apoptotic process), GO:0006915 (apoptotic process), GO:0033043 (regulation of organelle organization), GO:1902533 (positive regulation of intracellular signal transduction), GO:0097191 (extrinsic apoptotic signaling pathway), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0001836 (release of cytochrome c from mitochondria), GO:0097435 (supramolecular fiber organization), GO:1902531 (regulation of intracellular signal transduction), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0072657 (protein localization to membrane), GO:0007005 (mitochondrion organization), GO:0043065 (positive regulation of apoptotic process), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0042981 (regulation of apoptotic process), GO:0010821 (regulation of mitochondrion organization), GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway), GO:0010822 (positive regulation of mitochondrion organization), GO:0008637 (apoptotic mitochondrial changes), GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors), GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway), GO:0090200 (positive regulation of release of cytochrome c from mitochondria), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:1904019 (epithelial cell apoptotic process), GO:0090199 (regulation of release of cytochrome c from mitochondria), GO:0097284 (hepatocyte apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)