Protein: Plexin-A2 (A0A2R8QPJ6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Sequence: MGGQQDSQRTLKQSPGQGFTLSFTCWLLVLILPVVCCEQSFTTFYPERREWAFNHLTVHKTTGALYIGAVNRVYKLSGNLTLLVSHDTGPEDDNKACYPPLIVQPCSEPLISTNNINKLLLIDYSQNRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNQTGTMYGVIVPSQGKDGTLFIGTAVDGKQDYFPTISSRKLPRDPESSAMLDYELHTDFVSSLIKIPSDTLALVSHFDIYYIYGFASGNFVYFLTVQPETPENSMSSSGPSNDLFYTSRIVRLCKDDHKFHSYVSLPIGCVRNRVEYRLLQAAYLGKPGRVFAASLNISAQDDVLFAVFSKGQKQYHHPPDDSALCVFSIRDINARIKERMQSCYQGEGNLELNWLLGKDVPCTKAPVPIDDSFCGLDINQPLGGSQLVTGHTLYTESRDRMTSVTSYVYNGFCVAFVGTKSGRLKKIRVDGPPQGGVQYETLSVIKDGNSILRDMAFSLDNSYIYVMSERQVTRVPIESCEQYSTCGECLSSGDPHCGWCVLHNICSQRDRCERANEPYRFAATLNQCVKATVYPDSIAVSEPSVPLLVKVTDVPDLSAGITCSFGNLTEVEGRVNGNQILCISPAAKDVPIIPADQDWSGVELRLNSKETGQMLISTEVKFYNCSVHQLCLSCVTSSFRCHWCKYRNLCTHDPSSCSFQEGRVNASEDCPQLVRSEEILIPAGEVKPITLKARNLPQPQSGQRGYECVLHIQGVSHRVTALRFNSSSVQCQNSSYLYEGMRISELPVDFSVVWNGNFIIDNPENIKVHLYKCGAQRDSCGVCLKAERKFQCGWCSMEGRCTLRQHCPMTNPYTSRWLHLASTNVKCTNPRITEVTPVAGPPEGGTRVTIRGVNLGLSFSDMVNNVQVAGVQCTPQENGYIIAEQIVCEMDAAPVDSKAGPVHLCVGECKPELQTRSSQLYSFVMPSVTGLSPSRGPESGGTKVTIMGENLGAGSSVTVLFGNQTCEFYERTMTEIVCYSAPSLTGVGSVQISVSVDRAQVRDILAFEYIDDPTVQRIEPEWSIASGHTPLVVTGTNLDVIQEPRIRIKYGGRESVNVCKVLNTTTMSCFAPSLTAEYRPGLDSVKHADEFGFIFNNVQALLVYNNTNFMYYPNPFFEPLSTNGVLEQKPGSPIILKGKNLVPSAAGGVKLNYTVLIGETPCSVTVSESQLLCEPPNLTGQYKIMVQVGGLHVSPGSVNILSDSLLTLPAIVSIAAGGGLLLIIVILVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRAGIPYLDYRTYAMRVLFPGIEDHPVLRELEVSGNGQLCVEKALKLFAQLINNKVFLLTFIRTLEMQRSFSMRDRGNVASLIMTALQGRLEYATDVLKHLLSDLIDKNLESKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLILNCVNPENENSPEIPVKVLNCDTITQVKEKILDAVYKNMPYSQRPKAVDMDLEWRQGRMARVVLQDEDITTKIENDWKRLNTLMHYQVSDRCVVALVPKQTSSYNIPPTTSISRTSISRYDSTFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADKHGIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKNWVERYYADISRLPAISDQDMNAYLAEQARLHSSEFNMLSALNEIYSYISKYSEEITAALDQDETAKKQRLAYKVEQLIAAMSLES
InterPro domains: - IPR002909: IPT domain (domain) [865-1245]
- IPR016201: PSI domain (domain) [515-864]
- IPR041019: Plexin, TIG domain 1 (domain) [571-659]
- IPR036352: Sema domain superfamily (homologous_superfamily) [47-513]
- IPR031148: Plexin family (family) [27-1898]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [35-514]
- IPR001627: Sema domain (domain) [27-513]
- IPR046800: Plexin, cytoplasmic RhoGTPase-binding domain (domain) [1493-1605]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [526-1151]
- IPR002165: Plexin repeat (repeat) [515-863]
- IPR013548: Plexin, cytoplasmic RasGAP domain (domain) [1319-1872]
- IPR041362: Plexin, TIG domain 2 (domain) [713-807]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [863-1231]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [1279-1879]
Interaction partners: - Sema domain, immunoglobulin domain
- Neuropilin-1a
- Sema domain, transmembrane domain
- Sema domain, immunoglobulin domain
- Semaphorin-2A
- Sema domain, transmembrane domain
- Semaphorin-3D
- Sema domain, seven thrombospondin repeats
- Semaphorin 7A
- Semaphorin-3aa
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0008037 (cell recognition), GO:0071840 (cellular component organization or biogenesis), GO:0001763 (morphogenesis of a branching structure), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0008038 (neuron recognition), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007414 (axonal defasciculation), GO:0007399 (nervous system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)