Protein: Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member) (A0A6H2EEY2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}.
Sequence: MIFPREKKVLWRYASSNNPSNGVSAAPPAQPPRPPPPPHRPRPHQCTPSFGYSCNEEDSLAMRQTPLPPYSSIACGMDCSSSNSSSCGQSLSLSQGQGHNNNNSHPYRRLPNHMDVLPPPPSACDRCCTAPGYSCASSCDDMLIDGSDLDQDRSPDQGQVQPVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAHPPQTQAQNGKRFREDFEALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWEPHVTASRLFFWRELWNAKELKRLPTCPAARDCIYMCCNPLHWFRILHQPETESPTPPYQRSKMLRLKDADFEEDSQNDAKSAALSTWSAESTSISNIYKPALYESVTTDGKDHNINSQVWCQIAYWEMAHRVGEFFHAKTNAVNIYTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENGDVWIYNRGNTTIFVDSPTLSENLDRVCKVMPGYCLKAFETNRAELLSMRDHGHHPMGPVDYFSIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYLMLARSAGPHSASQHLVEPGMGCACDQVSSWRSRQLLQKAQKLLTRLCRQVCALTDYRPARTRWRCLAGRRSSRQLNTKQPIIWNNKGLQKKSF
InterPro domains: - IPR003619: MAD homology 1, Dwarfin-type (domain) [212-329]
- IPR017855: SMAD-like domain superfamily (homologous_superfamily) [390-575]
- IPR013019: MAD homology, MH1 (domain) [192-331]
- IPR036578: SMAD MH1 domain superfamily (homologous_superfamily) [190-332]
- IPR001132: SMAD domain, Dwarfin-type (domain) [398-589]
- IPR013790: Dwarfin (family) [209-569]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [372-564]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0033612 (receptor serine/threonine kinase binding), GO:0070696 (transmembrane receptor protein serine/threonine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0007389 (pattern specification process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0016049 (cell growth), GO:0050794 (regulation of cellular process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0098727 (maintenance of cell number), GO:0045926 (negative regulation of growth), GO:0019827 (stem cell population maintenance), GO:0040008 (regulation of growth), GO:0032989 (cellular component morphogenesis), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0048729 (tissue morphogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0009826 (unidimensional cell growth), GO:0048513 (animal organ development), GO:0050803 (regulation of synapse structure or activity), GO:0044087 (regulation of cellular component biogenesis), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048635 (negative regulation of muscle organ development), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0002164 (larval development), GO:0009886 (post-embryonic animal morphogenesis), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0048634 (regulation of muscle organ development), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0048736 (appendage development), GO:0030718 (germ-line stem cell population maintenance), GO:0007442 (hindgut morphogenesis), GO:0035107 (appendage morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0048640 (negative regulation of developmental growth), GO:0051964 (negative regulation of synapse assembly), GO:0007488 (histoblast morphogenesis), GO:0048619 (embryonic hindgut morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0050807 (regulation of synapse organization), GO:0055123 (digestive system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0007443 (Malpighian tubule morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0048666 (neuron development), GO:0007447 (imaginal disc pattern formation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0061326 (renal tubule development), GO:0007399 (nervous system development), GO:0048737 (imaginal disc-derived appendage development), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0008582 (regulation of synaptic assembly at neuromuscular junction), GO:0007444 (imaginal disc development), GO:0048858 (cell projection morphogenesis), GO:0002168 (instar larval development), GO:0072001 (renal system development), GO:0090254 (cell elongation involved in imaginal disc-derived wing morphogenesis), GO:1901888 (regulation of cell junction assembly), GO:0035120 (post-embryonic appendage morphogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0051960 (regulation of nervous system development), GO:0048546 (digestive tract morphogenesis), GO:1901889 (negative regulation of cell junction assembly), GO:1905809 (negative regulation of synapse organization), GO:0022008 (neurogenesis), GO:0048569 (post-embryonic animal organ development), GO:0045886 (negative regulation of synaptic assembly at neuromuscular junction), GO:0072002 (Malpighian tubule development), GO:0060429 (epithelium development), GO:0048565 (digestive tract development), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0007472 (wing disc morphogenesis), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0007448 (anterior/posterior pattern specification, imaginal disc), GO:1904397 (negative regulation of neuromuscular junction development), GO:1904396 (regulation of neuromuscular junction development), GO:0061333 (renal tubule morphogenesis), GO:0051963 (regulation of synapse assembly), GO:0007411 (axon guidance), GO:0048699 (generation of neurons), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0035214 (eye-antennal disc development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0061525 (hindgut development), GO:0035220 (wing disc development), GO:0031175 (neuron projection development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0031290 (retinal ganglion cell axon guidance), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)