wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: ORF6 protein (P0DTC6)
Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Function: Disrupts bidirectional nucleocytoplasmic transport by interacting with the host RAE1-NUP98 complex. Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (By similarity). Prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities. Suppresses IFN-beta production possibly by blocking IRF3 nuclear translocation. Might induce accumulation of host HNRNPA1
Subcellular location: Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Note=Localizes to virus-induced vesicular structures called double membrane vesicles
Sequence: MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLTENKYSQLDEEQPMEID
InterPro domains: - IPR022736: Non-structural protein NS6, betacoronavirus (family) [1-61]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Non-toxic nonhemagglutinin (A0A5P3XKL4)
Organism: Paraclostridium bifermentans (Clostridium bifermentans)
Function: Expression of the ptox operon (ntnh-orfX1-orfX2-orfX3-pmp1) in B.thuringiensis kills Anopheles but not Aedes mosquito 3rd instar larvae. The ntnh-pmp1 construct is about half as toxic
Sequence: MDIIDNVDITLPENGEDIVIVGGRRYDYNGDLAKFKAFKVAKHIWVVPGRYYGEKLDIQDGEKINGGIYDKDFLSQNQEKQEFMDGVILLLKRINNTLEGKRLLSLITSAVPFPNEDDGIYKQNNFILSDKTFKAYTSNIIIFGPGANLVENKVIAFNSGDAENGLGTISEICFQPLLTYKFGDYFQDPALDLLKCLIKSLYYLYGIKVPEDFTLPYRLTNNPDKTEYSQVNMEDLLISGGDDLNAAGQRPYWLWNNYFIDAKDKFDKYKEIYENQMKLDPNLEINLSNHLEQKFNINISELWSLNISNFARTFNLKSPRSFYKALKYYYRKKYYKIHYNEIFGTNYNIYGFIDGQVNASLKETDLNIINKPQQIINLIDNNNILLIKSYIYDDELNKIDYNFYNNYEIPYNYGNSFKIPNITGILLPSVNYELIDKIPKIAEIKPYIKDSTPLPDSEKTPIPKELNVGIPLPIHYLDSQIYKGDEDKDFILSPDFLKVVSTKDKSLVYSFLPNIVSYFDGYDKTKISTDKKYYLWIREVLNNYSIDITRTENIIGIFGVDEIVPWMGRALNILNTENTFETELRKNGLKALLSKDLNVIFPKTKVDPIPTDNPPLTIEKIDEKLSDIYIKNKFFLIKNYYITIQQWWICCYSQFLNLSYMCREAIINQQNLIEKIILNQLSYLARETSINIETLYILSVTTEKTIEDLREISQKSMNNICNFFERASVSIFHTDIYNKFIDHMKYIVDDANTKIINYINSNSNITQEEKNYLINKYMLTEEDFNFFNFDKLINLFNSKIQLTIKNEKPEYNLLLSINQNESNENITDISGNNVKISYSNNINILDGRNEQAIYLDNDSQYVDFKSKNFENGVTNNFTISFWMRTLEKVDTNSTLLTSKLNENSAGWQLDLRRNGLVWSMKDHNKNEINIYLNDFLDISWHYIVVSVNRLTNILTVYIDGELSVNRNIEEIYNLYSDVGTIKLQASGSKVRIESFSILNRDIQRDEVSNRYINYIDNVNLRNIYGERLEYNKEYEVSNYVYPRNLLYKVNDIYLAIERGSNSSNRFKLILININEDKKFVQQKDIVIIKDVTQNKYLGISEDSNKIKLVDRNNALELILDNHLLNPNYTTFSTKQEEYLRLSNIDGIYNWVIKDVSRLNDIYSWTLI
InterPro domains: - IPR036248: Clostridium neurotoxin, translocation domain (homologous_superfamily) [472-808]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [817-1000]
- IPR013677: Non-toxic nonhaemagglutinin, C-terminal (domain) [1011-1165]
- IPR054379: Non-toxic nonhaemagglutinin, helical domain (domain) [486-754]
- IPR000395: Botulinum/Tetanus toxin, catalytic chain (domain) [6-276]
- IPR012928: Clostridium neurotoxin, receptor binding N-terminal (domain) [823-1002]
- IPR058583: Non-toxic nonhemagglutinin (family) [1-1155]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0051701 (biological process involved in interaction with host), GO:0044003 (modulation by symbiont of host process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm)
Protein: Nuclear pore complex protein Nup160 (P83722)
Organism: Xenopus laevis (African clawed frog)
Function: Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport
Subcellular location: Nucleus, nuclear pore complex. Cytoplasm
Sequence: PVNIYVIMADQGPAHLPVSLAVHTDMLEYVPVSKDEYFQKLKKA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Putative tyrosine-protein phosphatase OCA1 (Q59XY9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Putative tyrosine-protein phosphatase required for protection against superoxide stress
Subcellular location: Cytoplasm
Sequence: MASITSNSQILINNDSSTNKAPTTNERQLRRINHPPNLRIVPPLNFCPVENQLYRSGQPSIINQSFLNQLNLKTIIWLSSEEPTDEFLEYCNDSSINIEYLGMINEFNSEPATATTTDKQSQSQSQSQSEEQKSQSQSQSQENQHHQFEQSDNNLLQDPSHLISSTIAKINNNNPWDSLNENTIKHALDLIVDKTNYPILICCGMGRHRTGTVIGCLRRLQHWNLNSVSEEYRRFTGSRGGRILVELLIESFNIDLVNINWELAPDWLK
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [39-255]
- IPR004861: Atypical dual-specificity phosphatase Siw14-like (family) [40-262]
- IPR020422: Dual specificity protein phosphatase domain (domain) [45-261]
Interaction partners: - Uncharacterized protein
- diphosphoinositol-polyphosphate diphosphatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein OrfX1 (A0A5P3XKM0)
Organism: Paraclostridium bifermentans (Clostridium bifermentans)
Function: Expression of the ptox operon (ntnh-orfX1-orfX2-orfX3-pmp1) in B.thuringiensis kills Anopheles but not Aedes mosquito 3rd instar larvae. The ntnh-pmp1 construct is about half as toxic
Sequence: MNREFPFHFNDGNVSMNGLFCLKKIKTQYHPNYDYFKIKFCEGFLSIKNKVKDDLCEYDLKNIESVIALKREYSKENNLKNKESAIFMNIGNKGIHNKYDLYVVNVDINNILDENYMLKGILNDKLKILFLGNERKLLRIKN
InterPro domains: - IPR058823: Orfx1, TULIPs domain (domain) [1-140]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0019049 (mitigation of host antiviral defense response), GO:0030682 (mitigation of host defenses by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein OrfX2 (A0A5P3XKJ3)
Organism: Paraclostridium bifermentans (Clostridium bifermentans)
Function: Expression of the ptox operon (ntnh-orfX1-orfX2-orfX3-pmp1) in B.thuringiensis kills Anopheles but not Aedes mosquito 3rd instar larvae. The ntnh-pmp1 construct is about half as toxic
Sequence: MSKKPLDFLRIYDWHKTEAMNKISKLDFERIIPKHFSKEIKNKHLSVKITGNWKIWKLTDEGEGQYPIFKCIVEDGFLKIKNECGNKKYSLDNAWIKICTKIKYDNENGKDIYSIDEKNLTLYSVNNSFNSKYKNNIVDAFLDNLLIACIEDNIKDLNKFFKLYKVKTAIKEDLSLLGWDTGYSTSFTHVNKTIENQQNYPKQFKYESEGPYNIDISGEFDSWRLTTGSDGQNVNFICPIKNGEFNFLGTEYKFSQGEQVNIQLKLKYLNIEEPTFEDSTSLNDGNQVDLIVKTDEDENENPPVTIIKVVLLGEIDAIGKMLLEGTFREWFNENIDAFKQIFSSFLLEDTSKNPDFQWLKPTKAYYGVASAEPIDGKPDLDSSVFSVMSMVEDNKNDKPSHTVDGRILDAVNNESAFGIRTPLFVKKWLIAGLEMMQIGKLEDFDLINNGMGFINNKKLLFGTFENADGEDVPAYVEKDNFRLEITNNQLKIEITDIYWQQSRRLTGHVMYSQYFDLELRSGTDITGAEYKNILIPVENSEPTLVVNISQDEFDIWGDIVGEIVGGIVVGIVTGYLGSILGKGVGKYLEKFLTKTSGGRWVLKMNKEMYDYLNNLFKGDRRVFNEVAIDEIELISTLGTSQAISTIANTPTNFASKIWVNKSKFIGGLIGGSVGSVIPSVIIKSIDAWDKQNYSVLPSINAFVASSVGSVKWPDTSEFKIESAELNGIFLLGGKLERYEK
InterPro domains: - IPR010567: Protein OrfX2/OrfX3/P47 (domain) [177-493]
- IPR058824: Orfx2, N-terminal TULIPs domain (domain) [6-173]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0019058 (viral life cycle), GO:0019076 (viral release from host cell), GO:0044403 (biological process involved in symbiotic interaction), GO:0140975 (disruption of cellular component of another organism), GO:0051701 (biological process involved in interaction with host), GO:0044659 (viral release from host cell by cytolysis), GO:0051673 (disruption of membrane integrity in another organism), GO:0044003 (modulation by symbiont of host process), GO:0052111 (modification by symbiont of host structure), GO:0001907 (killing by symbiont of host cells), GO:0044000 (movement in host), GO:0052043 (modification by symbiont of host cellular component), GO:0001897 (cytolysis by symbiont of host cells), GO:0035891 (exit from host cell), GO:0052025 (modification by symbiont of host cell membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033655 (host cell cytoplasm part), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0044165 (host cell endoplasmic reticulum)
Protein: Ubiquitin thioesterase otubain-like (Q9VL00)
Organism: Drosophila melanogaster (Fruit fly)
Function: Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation
Sequence: MEPFTHNDGNRDELIIQQKRDIEKEISDTTPLVSEQLPLTCLYAEYSGDEIFTAKIQDLSKKYKFIRRTRPDGNCFFRAFAYSYLEYLISNTSAYQEFKKLAEESKEKLVQLGFPSFTLEDFHETFMEVIQRVSPDNAGGHSTVQDELHKIFNEQGYSDYVVVYLRLITSGKLQEEADFYQNFIEGDLTIEAFRHLEVEPMYKESDHIHIIALCTALGAGVRVEYLDRGEGGTVKAHDFPEGSEPRIYLIYRPGHYDILYPN
InterPro domains: - IPR019400: Peptidase C65, otubain (family) [27-261]
- IPR042467: Peptidase C65, otubain, subdomain 2 (homologous_superfamily) [70-219]
- IPR003323: OTU domain (domain) [64-262]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [31-261]
- IPR042468: Peptidase C65, otubain, subdomain 1 (homologous_superfamily) [31-260]
- IPR016615: Ubiquitin thioesterase Otubain (family) [8-262]
Interaction partners: - Ubiquitin-conjugating enzyme E2-17 kDa
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin
- Ubiquitin
- Ubiquitin-conjugating enzyme E2 N
- AT16033p
- Ubiquitin-ribosomal protein eL40 fusion protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0031625 (ubiquitin protein ligase binding), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity), GO:1990380 (K48-linked deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070646 (protein modification by small protein removal), GO:0070647 (protein modification by small protein conjugation or removal), GO:0016579 (protein deubiquitination), GO:0071108 (protein K48-linked deubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Probable cyclic di-GMP phosphodiesterase PdeI (P75800)
Organism: Escherichia coli (strain K12)
Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MLSLYEKIKIRLIILFLLAALSFIGLFFIINYQLVSERAVKRADSRFELIQKNVGYFFKDIERSALTLKDSLYLLKNTEEIQRAVILKMEMMPFLDSVGLVLDDNKYYLFSRRANDKIVVYHQEQVNGPLVDESGRVIFADFNPSKRPWSVASDDSNNSWNPAYNCFDRPGKKCISFTLHINGKDHDLLAVDKIHVDLNWRYLNEYLDQISANDEVLFLKQGHEIIAKNQLAREKLIIYNSEGNYNIIDSVDTEYIEKTSAVPNNALFEIYFYYPGGNLLNASDKLFYLPFAFIIIVLLVVYLMTTRVFRRQFSEMTELVNTLAFLPDSTDQIEALKIREGDAKEIISIKNSIAEMKDAEIERSNKLLSLISYDQESGFIKNMAIIESNNNQYLAVGIIKLCGLEAVEAVFGVDERNKIVRKLCQRIAEKYAQCCDIVTFNADLYLLLCRENVQTFTRKIAMVNDFDSSFGYRNLRIHKSAICEPLQGENAWSYAEKLKLAISSIRDHMFSEFIFCDDAKLNEIEENIWIARNIRHAMEIGELFLVYQPIVDINTRAILGAEALCRWVSAERGIISPLKFITIAEDIGFINELGYQIIKTAMGEFRHFSQRASLKDDFLLHINVSPWQLNEPHFHERFTTIMKENGLKANSLCVEITETVIERINEHFYLNIEQLRKQGVRISIDDFGTGLSNLKRFYEINPDSIKVDSQFTGDIFGTAGKIVRIIFDLARYNRIPVIAEGVESEDVARELIKLGCVQAQGYLYQKPMPFSAWDKSGKLVKE
InterPro domains: - IPR035919: EAL domain superfamily (homologous_superfamily) [529-779]
- IPR033418: Periplasmic sensor domain, extracellular (domain) [35-150]
- IPR001633: EAL domain (domain) [526-781]
- IPR050706: Cyclic di-GMP phosphodiesterase-like (family) [90-778]
Interaction partners: - Probable diguanylate cyclase DgcI
- Probable diguanylate cyclase DgcJ
- Probable diguanylate cyclase CdgI
- Probable diguanylate cyclase DgcT
- Diguanylate cyclase DgcM
- Cyclic di-GMP phosphodiesterase PdeH
- Probable diguanylate cyclase DgcC
- Diguanylate cyclase DgcZ
- Diguanylate cyclase DgcP
- Probable diguanylate cyclase DgcF
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0071111 (cyclic-guanylate-specific phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein disulfide-isomerase A2 (D3Z6P0)
Organism: Mus musculus (Mouse)
Function: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity)
Subcellular location: Endoplasmic reticulum lumen
Sequence: MDKQLLPVLLLLLGVSGSWGQGEEPGGPSEVLPEEPTGEEVPKEDGILVLNHRTLSLALQEHSALMVEFYAPWCGHCKELAPEYSKAAALLAAESAVVTLAKVDGPAEPELTKEFEVVGYPTLKFFQNGNRTNPEEYAGPKTAEGIAEWLRRRVGPSATHLEDEEGVQALMAKWDMVVIGFFQDLQGKDMATFLALAKDALDMTFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKETGLDLGDLSRFLVIHSMHLVTEFNSQTSPKIFAAKILNHLLLFVNQTLAQHRELLTDFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAEEAPTLRLINVETTKKYAPTGVIAITAASVAAFCQAVLHGEIKHYLLSQEIPPDWDQGPVKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYKDREDIVIAELDATANELEAFSVLGYPTLKFFPAGPDRKVIDYKSTRDLETFSKFLDSGGHLPKEEPKEPAASAPEAQANSTLGPKEEL
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [43-498]
- IPR005792: Protein disulphide isomerase (family) [47-521]
- IPR013766: Thioredoxin domain (domain) [29-499]
- IPR017937: Thioredoxin, conserved site (conserved_site) [66-84]
Interaction partners: - Endoplasmic reticulum chaperone BiP
- Endoplasmin
- ERO1-like protein beta
- DnaJ homolog subfamily B member 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016860 (intramolecular oxidoreductase activity), GO:0003756 (protein disulfide isomerase activity), GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0051651 (maintenance of location in cell), GO:0051235 (maintenance of location), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0032507 (maintenance of protein location in cell), GO:0045185 (maintenance of protein location), GO:0032507 (maintenance of protein location in cell), GO:0072595 (maintenance of protein localization in organelle), GO:0008104 (protein localization), GO:0033365 (protein localization to organelle), GO:0070972 (protein localization to endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)