Protein: Protein phosphatase 1A (Q6NYP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor. Nucleus
Sequence: MGAFLDKPKMEKHNAHGDGNSLRYGLSSMQGWRVEMEDAHTAVIGLPNSLDLWSFFAVYDGHAGSQVARYCCEHLLEHITSNPDFQGGGGGGGPAVEPSVDSVKSGIRTGFLQIDDHMRQISEKKHGGADRSGSTAVGVMISPRHIYFINCGDSRGLLSRGGAVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVCAIERSEAEDEFIVLACDGIWDVMANEELCDFVRSRLEVTDDLERVCNEIVDTCLYKGSRDNMSVVLVCFVSAPKVSPEAVKREAELDKYLESRVEEILKRQGDEGVPDLVHVMRTLASESIPNLPPGGELASKRSVIEAVYNKLNPYRNEDTVLL
InterPro domains: - IPR015655: Protein phosphatase 2C (family) [19-296]
- IPR000222: PPM-type phosphatase, divalent cation binding (binding_site) [55-63]
- IPR001932: PPM-type phosphatase-like domain (domain) [13-298]
- IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [1-302]
- IPR036580: Phosphatase 2C, C-terminal domain superfamily (homologous_superfamily) [303-376]
- IPR012911: Protein serine/threonine phosphatase 2C, C-terminal (domain) [292-371]
Interaction partners: - Dual specificity mitogen-activated protein kinase kinase 7
- mitogen-activated protein kinase kinase
- mitogen-activated protein kinase kinase
- Dual specificity mitogen-activated protein kinase kinase 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway), GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)