Protein: Hypha-specific G1 cyclin-related protein 1 (Q5ABE2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throughout hyphal growth. Moreover CDC28-HGC1 phosphorylation of EFG1 represses cell separation genes during hyphal growth. Also partially controls SEP7 phosphorylation status and subsequent septin ring dynamics. Required for virulence and especially mediates dynamic adhesion to endothelium of blood vessels during circulation
Sequence: MINITKPLTPKSISQQKQQQQHPYKNISTTKSNNNPQASGSKSFVQEKYPSQLYESEIKIHNQSLAEYDLDIYDIMVNLIETNKPNLSLYKQQPYLTFTIRLKLIDFLLKMSIRLKILPFVFFKAVKIFDRYCSKRIVLLDQSQLIITTCLWIASKVMGGNNHFVNINNLDKIGHENFRTINDLGYGCGGKYLGPTERFRLPKLHELVKLCGAKCKYDQGMFKQMEVHVLNTLEWSLNDPSIEEFIIDSHEFNVININNNNEYEQTITTNDESANANANDGNEFFKIKEFLSYAALYSHDLIDTNIIELGQVIMDLINETFQLQPFDKHYQTILNCDSDHPIRFDMQRYKHIKKAVIKSVLNASDFMMKVFHSKGPQFIYQQFNLQYKLNYTTNSIIGGFGNSGYSPTTTTTTTTSDNISTTPTSSTGSTTPVSSYIGYANSRSSSVSSTSSVASSSNANTPSSSCSTTSTTPLGMTPHKRQKNYSNYSNYSNYSNSSTSLGLTNNNNNNTTISPVDSTTINSHTKNSSQLNYQYHNGGSNNNNHHHHHKPSLSVSIPPPQMHSHHHSSTVYQMVTPPNSANKNSNKSNSANNNNTTTIATTTTTTTNNNNNSQLPAPHQLSYNNYFNSPNMQPPPPMKYTPGRKQQQQQNQGQNQQQPLQLYQGDNNNNGTNTNSKFNSIAGSRAVSSSSSSAVSIASSISTNNYDKYDDDDDDDNSNDLFSSSRRFMNYSNYSSSTINGSVMSGVINNNSGNGKGNGNGGSGTPISENDSPIYTKTRLCNMIH
InterPro domains: - IPR013763: Cyclin-like domain (domain) [106-231]
- IPR006671: Cyclin, N-terminal (domain) [71-238]
- IPR048258: Cyclins, cyclin-box (conserved_site) [101-132]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [64-238]
Interaction partners: - Cyclin-dependent kinase 1
- Nucleoporin NSP1
- Transcriptional regulatory protein UME6
- Hyphal wall protein 1
- Extent of cell elongation protein 1
- G1/S-specific cyclin CLN3
- Transcription factor MBP1
- SCF ubiquitin ligase complex subunit
- Protein phosphatase PP2A regulatory subunit B
- Transcription factor MBP1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0030447 (filamentous growth), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007346 (regulation of mitotic cell cycle), GO:0051338 (regulation of transferase activity), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:0051246 (regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0043549 (regulation of kinase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:1990234 (transferase complex), GO:0043227 (membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex), GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)