Protein: hypoxia-inducible factor-proline dioxygenase (A0A590UJ78)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus
Sequence: XVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATR
InterPro domains: - IPR051559: Hypoxia-inducible factor prolyl hydroxylases (family) [1-175]
- IPR006620: Prolyl 4-hydroxylase, alpha subunit (domain) [1-175]
- IPR005123: Oxoglutarate/iron-dependent dioxygenase domain (domain) [83-175]
- IPR044862: Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain (domain) [91-172]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0031543 (peptidyl-proline dioxygenase activity), GO:0031545 (peptidyl-proline 4-dioxygenase activity), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0019222 (regulation of metabolic process), GO:0008219 (cell death), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0001666 (response to hypoxia), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0012501 (programmed cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0070482 (response to oxygen levels), GO:0019538 (protein metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0036293 (response to decreased oxygen levels), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:0051345 (positive regulation of hydrolase activity), GO:0052547 (regulation of peptidase activity), GO:0018126 (protein hydroxylation), GO:0018193 (peptidyl-amino acid modification), GO:0019511 (peptidyl-proline hydroxylation), GO:0018208 (peptidyl-proline modification), GO:0010952 (positive regulation of peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:0010950 (positive regulation of endopeptidase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:2001056 (positive regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)