Protein: ER protein translocation subcomplex subunit Sec63 (B6JXN5)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MSAEYKYDEQGAFFPVFLLVFVLAYAIPATLKECFGRKKKDAFTSCEDKLKHLRPKNGLDKQCKRIPKRYFAIVLAWILAIYLVYVIVQTRSNSALYDPYEILGLPKSSTLDEIRRHYKRLSIKFHPDKVRNLVNTTREEVELHYIEITKAYKALTDDEIRENYIKYGNPDGAQDLSIGIALPKWVVESKNSIYVLGFYGTLFGLLLPYSVGKWWYKTRNFTRESIRVGSVHRWFKNFDEDATADDLLKAFASSDEFRHDSKESVDESSKRVIRLLEERFQRKPSSNEHELEQVLRQSGNVLSGLLNLVSAFGFAKPLKNAMQLTQCMVQALPLDSTLYTLQLPHLKQEDAYKLALHGVKHISQFCDLTPNELSTLLPKYTKQQREEMSLVAGAIPRLCVTDAKVVVDGDEFVTSSAIATMILRVKCCYNKEKVKTVNVSGEEKCTEEDEKLFSQNKETAVGDKECLPAAWAPYFSQRFKPVWWVYVEDPRQGRVVVPPVALTDIPKTSRTVTIPFQAPPTPGTYHFRGHVVSNAFCGEDVLLNITVEVKDPAELVSDVPEKSAKGMDEDSAYDVDTEDDNSSDEEDMDDSLSDMFDTDTSVSDLEDEDEDGEEDEHKKNQAVDEEKSTTK
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [430-556]
- IPR004179: Sec63 domain (domain) [217-547]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [402-551]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [86-177]
- IPR001623: DnaJ domain (domain) [97-168]
Interaction partners: - Translocation protein SEC62
- ER protein translocation subcomplex subunit Sec72
- ER protein translocation subcomplex subunit Sec66
- Translocon alpha subunit Sec61
- Protein transport protein Sec61 subunit beta
- Translocon gamma subunit Sss1
- Translocon subunit Sec61
- RNA helicase
- Endoplasmic reticulum chaperone BIP
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0071806 (protein transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0065002 (intracellular protein transmembrane transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0045037 (protein import into chloroplast stroma), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0072596 (establishment of protein localization to chloroplast), GO:0072598 (protein localization to chloroplast), GO:0045036 (protein targeting to chloroplast)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)