Protein: Solute carrier family 25 member 36 (Q96CQ1)
Organism: Homo sapiens (Human)
Function: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate. May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism. Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:25320081}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG
InterPro domains: - IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [4-309]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [3-310]
- IPR002067: Mitochondrial carrier protein (family) [9-255]
- IPR049562: Solute carrier family 25 member 33/36-like (family) [1-310]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:0015215 (nucleotide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0045927 (positive regulation of growth), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0001558 (regulation of cell growth), GO:1990542 (mitochondrial transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0030307 (positive regulation of cell growth), GO:0043170 (macromolecule metabolic process), GO:0072531 (pyrimidine-containing compound transmembrane transport), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901360 (organic cyclic compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0006139 (nucleobase-containing compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:1901679 (nucleotide transmembrane transport), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0071705 (nitrogen compound transport), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:0051881 (regulation of mitochondrial membrane potential), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0043434 (response to peptide hormone), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:1903426 (regulation of reactive oxygen species biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0010467 (gene expression), GO:0007005 (mitochondrion organization), GO:0016070 (RNA metabolic process), GO:0015748 (organophosphate ester transport), GO:0071375 (cellular response to peptide hormone stimulus), GO:0065003 (protein-containing complex assembly), GO:0032868 (response to insulin), GO:0015931 (nucleobase-containing compound transport), GO:1901653 (cellular response to peptide), GO:0043457 (regulation of cellular respiration), GO:0140053 (mitochondrial gene expression), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0000959 (mitochondrial RNA metabolic process), GO:0032869 (cellular response to insulin stimulus), GO:0006862 (nucleotide transport), GO:1990314 (cellular response to insulin-like growth factor stimulus), GO:0006390 (mitochondrial transcription), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0006351 (DNA-templated transcription), GO:1903715 (regulation of aerobic respiration), GO:0017004 (cytochrome complex assembly), GO:0000002 (mitochondrial genome maintenance), GO:0017062 (respiratory chain complex III assembly), GO:0034551 (mitochondrial respiratory chain complex III assembly), GO:0002082 (regulation of oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)