Protein: A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2) (Q9UNA0)
Organism: Homo sapiens (Human)
Function: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration (By similarity). Participates in development of brown adipose tissue and browning of white adipose tissue (By similarity). Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18992360}.
Sequence: MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGTSAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
InterPro domains: - IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [267-476]
- IPR041645: ADAMTS, cysteine-rich domain 2 (domain) [487-554]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [264-477]
- IPR006586: ADAM, cysteine-rich domain (domain) [483-556]
- IPR013273: ADAMTS/ADAMTS-like (family) [576-731]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [567-929]
- IPR050439: ADAMTS and ADAMTS-like (family) [290-930]
- IPR013276: Peptidase M12B, ADAM-TS5 (family) [19-210]
- IPR010294: ADAMTS/ADAMTS-like, Spacer 1 (domain) [734-852]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [567-930]
- IPR045371: ADAMTS/ADAMTS-like, cysteine-rich domain 3 (domain) [628-731]
Interaction partners: - Aggrecan core protein
- Syndecan-4
- Brevican core protein
- Collagenase 3
- Stromelysin-1
- Metalloproteinase inhibitor 3
- Collagen alpha-1
- Runt-related transcription factor 2
- Interleukin-1 beta
- Metalloproteinase inhibitor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0050840 (extracellular matrix binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:1901681 (sulfur compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0097367 (carbohydrate derivative binding), GO:0008201 (heparin binding), GO:0008233 (peptidase activity), GO:0005518 (collagen binding), GO:0005102 (signaling receptor binding), GO:0005539 (glycosaminoglycan binding), GO:0043394 (proteoglycan binding), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0008237 (metallopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)