Protein: Homeobox protein mab-5 (Protein male abnormal 5) (P10038)
Organism: Caenorhabditis elegans
Function: Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MSMYPGWTGDDSYWAGAGTTASSQSASSGTSASASSSAAAAAAANNLKTYELYNHTYMNNMKHMLAAGWMDNSSNPFAYNPLQATSANFGETRTSMPAISQPVFPWMKMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKEAKGEGGSNESDEESNQDEQNEQHSS
InterPro domains: - IPR001356: Homeodomain (domain) [115-179]
- IPR020479: Homeodomain, metazoa (domain) [139-173]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [96-175]
- IPR017970: Homeobox, conserved site (conserved_site) [150-173]
- IPR050296: Antennapedia-type homeobox (family) [26-191]
- IPR001827: Homeobox protein, antennapedia type, conserved site (conserved_site) [103-108]
Interaction partners: - Homeobox protein lin-39
- Homeobox protein egl-5
- Homeobox protein ceh-20
- Homeobox protein unc-62
- Protein Wnt
- Nuclear hormone receptor family member nhr-25
- Protein lin-32
- Axin-like protein pry-1
- Helix-loop-helix protein lin-22
- Homeobox protein ceh-34
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0035295 (tube development), GO:0045165 (cell fate commitment), GO:0001704 (formation of primary germ layer), GO:0001709 (cell fate determination), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0007492 (endoderm development), GO:0055123 (digestive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048732 (gland development), GO:0007369 (gastrulation), GO:0035272 (exocrine system development), GO:0048546 (digestive tract morphogenesis), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048568 (embryonic organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0048565 (digestive tract development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0009952 (anterior/posterior pattern specification), GO:0048566 (embryonic digestive tract development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)