Protein: Rab11 family-interacting protein 4 (FIP4-Rab11) (Rab11-FIP4) (Arfophilin-2) (Q86YS3)
Organism: Homo sapiens (Human)
Function: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
Subcellular location: Endosome {ECO:0000269|PubMed:20682791}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12857874}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12857874}. Recycling endosome membrane {ECO:0000269|PubMed:15601896}; Peripheral membrane protein. Cleavage furrow {ECO:0000269|PubMed:15601896}. Midbody {ECO:0000269|PubMed:12857874, ECO:0000269|PubMed:15601896}. Cytoplasmic vesicle {ECO:0000269|PubMed:15601896}. Note=Recruited to the cleavage furrow and the midbody during cytokinesis. {ECO:0000269|PubMed:15601896}.
Sequence: MAGGAGWSGAPAALLRSVRRLREVFEVCGRDPDGFLRVERVAALGLRFGQGEEVEKLVKYLDPNDLGRINFKDFCRGVFAMKGCEELLKDVLSVESAGTLPCAPEIPDCVEQGSEVTGPTFADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMESTQSLEGSVGSPAEKDGGLGGLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEGDDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGRGRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIKH
InterPro domains: - IPR019018: Rab-binding domain FIP-RBD (domain) [574-636]
- IPR051977: Rab11-interacting regulator of endocytosis and ciliogenesis (family) [10-636]
- IPR011992: EF-hand domain pair (homologous_superfamily) [18-79]
- IPR002048: EF-hand domain (domain) [49-84]
- IPR037245: FIP-RBD, C-terminal domain superfamily (homologous_superfamily) [585-636]
- IPR057316: Rab11-FIP3/4 domain (domain) [365-487]
Interaction partners: - Ras-related protein Rab-11A
- Rab11 family-interacting protein 3
- Rab11 family-interacting protein 2
- Rab11 family-interacting protein 1
- ADP-ribosylation factor 6
- Rab11 family-interacting protein 5
- Ras-related protein Rab-25
- ADP-ribosylation factor 5
- Homeobox protein goosecoid
- Unconventional myosin-Id
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0051640 (organelle localization), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0006810 (transport), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0009966 (regulation of signal transduction), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0001817 (regulation of cytokine production), GO:0045184 (establishment of protein localization), GO:0051647 (nucleus localization), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0015031 (protein transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0007097 (nuclear migration), GO:0071702 (organic substance transport), GO:0051252 (regulation of RNA metabolic process), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)