Protein: Solute carrier organic anion transporter family member 1A1 (Sodium-independent organic anion-transporting polypeptide 1) (OATP-1) (Solute carrier family 21 member 1) (Q9QXZ6)
Organism: Mus musculus (Mouse)
Function: Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4. Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000250|UniProtKB:P46720}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46720}.
Sequence: MEETEKKVATQEGRFFSKMKVFLMSLTCAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYFGRKLHRPIIIGVGCVVMGLGCFLMASPHFLMGRYKYETTISPTSNLSSNSFLCIENRTQTLKPTQDPTECVKEIKSLMWIYVLIGNTMRGIGETPIMPLGISYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLPKKELQDNVDVTKYEKVEKHRERAKKENLGITKDFLPFMKSLCCNPIYMLFSLTSVLQINGFASTFTFLPKYLEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGFIMKKFKITVKKAAYIAFGLSLSEYFIFLCNYLLTCDNFPVAGLTTSYKGVQHPLYGEKNVLADCNTRCSCLTDTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIGSSGNSSAVLGLCKKGPECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAGIPAPVYFGALIDRTCLHWGTLKCGQPGACRMYDINRFRHIYLGLPAAVRGSSFLPAVFILILMRKFHFPGDIHSPDTELAEMKLTEKESECTDVCRSPKVENDGELKTKL
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [15-574]
- IPR020846: Major facilitator superfamily domain (domain) [22-627]
- IPR002350: Kazal domain (domain) [433-488]
- IPR036058: Kazal domain superfamily (homologous_superfamily) [430-486]
- IPR004156: Organic anion transporter polypeptide (family) [3-649]
Interaction partners: - Solute carrier family 22, member 30)
- Hepatic sodium/bile acid cotransporter
- Solute carrier family 22 member 7
- Bile salt export pump
- NADPH-dependent 3-keto-steroid reductase Hsd3b5
- Cytochrome P450 7B1
- Cytochrome P450 7A1
- ATP-binding cassette sub-family C member 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0048589 (developmental growth), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0035264 (multicellular organism growth), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0055088 (lipid homeostasis), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0046483 (heterocycle metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0006082 (organic acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0006805 (xenobiotic metabolic process), GO:0042168 (heme metabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0055092 (sterol homeostasis), GO:0043436 (oxoacid metabolic process), GO:0008206 (bile acid metabolic process), GO:0055090 (acylglycerol homeostasis), GO:0008202 (steroid metabolic process), GO:0033013 (tetrapyrrole metabolic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0070328 (triglyceride homeostasis), GO:0042632 (cholesterol homeostasis), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)