Protein: Proton-coupled zinc antiporter SLC30A5 (Q5ZLF4)
Organism: Gallus gallus (Chicken)
Function: Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis
Subcellular location: Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Enriched in early compartments of the secretory pathway including COPII-coated vesicles and the Golgi cis cisterna
Sequence: MEEKYSSQALAGGGVLGPVDVPSARLTRYIVLLCFAKFLKAVGLFESYDLLKAVHLVQFIFIVKLGSAFFMVLFQKPFSSGKVVTKHQWIKIFKHAVVGCIISLLWFFGLTLCGPLRTLLLFEHSDVVVLSLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKIAEHPEGHHDSALTHVLYTVIAFLGVADHKGGVLLLVLALCCKVGFHMASRKLSVDVGGAKRLQALSHLVSVLLLCPWVIVLSLTTESKVESWSSLIMPFITVIFFVVILDFYVESICSVKMESSKCARYGSFLIFISALLFGNFWTHPITDQLRAMNKPAHHESTEHVLSGGVVVSAVFFILSANILSSPSRKGQKGTLIGYSPEGTPLYNFMGDAIQQSSQSLPRFIKESLKQILEEYDSRQIFYFLCLNLAFTFVELFYGVWTNSLGLISDGFHMLFDCSALVMGLFAALMTRWKATRIFSYGYGRVEILSGFINGLFLMVIAFFVFMESVARLVDPPDIDTNMLTPVSVGGLIVNLVGICAFSHAHSHGASRGGCHSHEHSHSYHGHSHSHGHGHSHNDHGHSHGHSHVSSGGGMNTNMRGVFLHVLADTLGSVGVIVSTTFIQQFGWLIADPLCSLFIATLIFLSVIPLLKDACQVLLLRIPPEQEKDLHAALEKIQKIDGVISYRDPHFWCHSASVVAGTIHVQVVSDVMEQRIVQQVTAILKDAGVNNLTVQVEKEAYFQHMSGLSTGFQDVLAMTQHLESMKYYKDGTYIM
InterPro domains: - IPR002524: Cation efflux (family) [413-734]
- IPR027469: Cation efflux transmembrane domain superfamily (homologous_superfamily) [412-654]
- IPR058533: Cation efflux protein, transmembrane domain (domain) [416-654]
- IPR045316: Zinc transporter Msc2-like (family) [28-738]
Interaction partners: - Zinc transporter ZIP9
- Zinc transporter ZIP13
- Zinc transporter 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015562 (efflux transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0051139 (metal cation:proton antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0055085 (transmembrane transport), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006882 (intracellular zinc ion homeostasis), GO:0006812 (monoatomic cation transport), GO:0071577 (zinc ion transmembrane transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0005794 (Golgi apparatus), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030667 (secretory granule membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0097708 (intracellular vesicle)