Protein: Transmembrane protease serine 13 (EC 3.4.21.-) (Membrane-type mosaic serine protease) (Mosaic serine protease) (Q9BYE2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451, ECO:0000269|PubMed:35796294}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:35796294}. Cytoplasm {ECO:0000269|PubMed:28710277}. Note=The non-phosphorylated, inactive full length protein localizes intracellularly (PubMed:28710277). N-glycosylation and phosphorylation is required for trafficking to the cell surface (PubMed:28710277, PubMed:34562451, PubMed:35796294). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (PubMed:34562451, PubMed:35796294). Proteolytic cleavage is required for secretion (PubMed:35796294). {ECO:0000269|PubMed:28710277, ECO:0000269|PubMed:34562451, ECO:0000269|PubMed:35796294}.
Sequence: MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMEVRSLQQDTAPSRLGTSSGGDPGGAPRL
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [352-516]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [317-560]
- IPR001254: Serine proteases, trypsin domain (domain) [325-559]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [362-367]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [505-516]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [314-559]
- IPR017327: Peptidase S1A, TMPRSS13 (family) [1-586]
- IPR036772: SRCR-like domain superfamily (homologous_superfamily) [220-320]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [210-226]
- IPR001190: SRCR domain (domain) [195-320]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0043170 (macromolecule metabolic process), GO:0045087 (innate immune response), GO:0002218 (activation of innate immune response), GO:0098542 (defense response to other organism), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0006508 (proteolysis), GO:0140546 (defense response to symbiont), GO:1900426 (positive regulation of defense response to bacterium), GO:0002922 (positive regulation of humoral immune response), GO:0002760 (positive regulation of antimicrobial humoral response), GO:0010628 (positive regulation of gene expression), GO:0002920 (regulation of humoral immune response), GO:0002225 (positive regulation of antimicrobial peptide production), GO:1900424 (regulation of defense response to bacterium), GO:0010468 (regulation of gene expression), GO:0002803 (positive regulation of antibacterial peptide production), GO:0002786 (regulation of antibacterial peptide production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030667 (secretory granule membrane), GO:0042599 (lamellar body), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle)