wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Zgc:64187 (Q7T298)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane
Sequence: MDPQQPERDWQQLEPSYGLKVFLTVLYCLILSLGVLGNSATIHVAQVLQRNGYLQRSVAEHMVSLACSDLLVLLIGLPVELYSAIWFPFLSRSGDAACRIYNFLFELCSYATILNVATLSLERYLAICHPFRYRALRGGRTRRLLLAAWLCSALVALPLLVATGTEGYVPAGRQTPVQNLTFCTSLSQHWVMYRTSIFTAFVLYLLVLAGVAFMCRAMILVLRAPMGPAEAGASGDHKHQSARGKASRKQTILFLVLIVCALFVCWMPNQIRRLMTAAVPKSSWTGSYLTSYIKLHPVADSFFYLSSVLNPMLYNLSSRQFRSAFLQTLLCRLSLQHANRRTLENSGASKSSNNTLRPLLQRSLNRIRMATSSRSTPPSSAERRDSLNTTDRPQGEGKLTLDPQNTTNWPQGEGELTSDSQEKERNQLTHCPTLPDEQSS
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [37-314]
- IPR052676: Zinc-sensing G-protein coupled receptor (family) [7-415]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [22-322]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008188 (neuropeptide receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0065008 (regulation of biological quality), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0042391 (regulation of membrane potential), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Pentraxin family member (A7E2J1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MLGFLFTLLNLTPAATEVGLGGKVLLFPTQTATSYVKLTPDKPLSLSAFTLCMRVATELQGGREVILFAYRTSEVDELNVWREKDGRLFMYIQSSSDGARFYLPPLSTFQTHLCVSWESATGLTALWVDGRRSLYQIYKKDASVRPGGTVLLGQDPDSYVGSFDANQCFIGEITDVKLWDYVLSEIQIKALYSNQDPLVPAGNVFDWNTVKYDVVGNVTVANDNL
InterPro domains: - IPR001759: Pentraxin domain (domain) [17-225]
- IPR030476: Pentaxin, conserved site (conserved_site) [112-119]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [19-221]
- IPR051005: Pentraxin domain-containing protein (family) [5-222]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)
Protein: Telomere repeat factor a (Q8JGS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome, telomere
Sequence: MSDKPCEPSWEQIINRWSFDFYAFQAFSAFRNGDYTAFTHFINIIESVVVRPVDGHTDMIPKLRLMQFLSRINNGDKLDLTFEEPKTPLESALDVLESICRDMSVPHTEQQLIRHAISEMLVMVCIRSGEFEKAEEMLKHFSSSSDSAGKKKLLLHLIRCRRSSHTVLQLSSYSHFKQDMLQFVERLFSVPEPFLLQMLRRSGWPSQRPEVRRSTQNNRRFTVKPSKRTPPHSSAAEDHGAECVSAVSRQGLQQVFDLLSEQYGVGISFFQLQDSVEAEAQQQQEGGVAGPELCLTLSETPMQTVILSDTEEQDEPRRYAGMTISRLVQEEDSQISAEHTHIEDEEEEEEQTHTHRGGDCSLSEPQCSSTQRSTPARLCKRSNTRVQQSESESQSSPAHRSTPARASHPSNPRSSTRKKTPSRRRIIESSDSENEQTTPAAATHTPRGQRQQHRSIRVSSGSEPEVDSTSPAAHTRRSTPTSTHTRTTKRSKWLDVSGIQDNWSDEDSLFHTSTAPAKKYTRKMWSVQESEWLKQGVVRYGVGHWERIRSAFPFAGRTAVNLKDRWRTMVKLKMV
InterPro domains: - IPR030657: Telomeric repeat-binding factor 2 (family) [7-575]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [524-572]
- IPR017930: Myb domain (domain) [525-574]
- IPR001005: SANT/Myb domain (domain) [517-572]
- IPR013867: Telomere repeat-binding factor, dimerisation domain (domain) [16-195]
- IPR036507: Telomere repeat-binding factor, dimerisation domain superfamily (homologous_superfamily) [5-203]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0042162 (telomeric DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000781 (chromosome, telomeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)
Protein: Pol protein (Q4JK02)
Organism: Human immunodeficiency virus type 1 (HIV-1)
Subcellular location: Host endosome, host multivesicular body. Virion membrane; Lipid-anchor
Sequence: PQITLWQRPLVTVRVGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTDMEKEGKISRIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVIYQYMDDLYVGSDLEIGQHRVKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCLRGTKALTEVVPLTQEAELELAENREILREPVHGVYYDPSKDLIAEVQKQGQD
InterPro domains: - IPR001995: Peptidase A2A, retrovirus, catalytic (domain) [20-89]
- IPR000477: Reverse transcriptase domain (domain) [143-333]
- IPR043502: DNA/RNA polymerase superfamily (homologous_superfamily) [104-430]
- IPR034170: Retropepsin-like catalytic domain (domain) [11-91]
- IPR001969: Aspartic peptidase, active site (active_site) [22-33]
- IPR010661: Reverse transcriptase thumb (domain) [340-402]
- IPR043128: Reverse transcriptase/Diguanylate cyclase domain (homologous_superfamily) [192-434]
- IPR018061: Retropepsins (domain) [6-97]
- IPR051320: Viral Replication and Maturation Polyprotein (family) [96-398]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [1-142]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process), GO:0006260 (DNA replication), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm)
Protein: Probable transcriptional regulator (Q746J7)
Organism: Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
Function: Not known
Sequence: MTSSGVYTIAEVEAMTGLSAEVLRQWERRYGFPKPRRTPGGHRLYSAEDVEALKTIKRWLEEGATPKAAIRRYLAQEVRPEDLGTGLLEALLRGDLAGAEALFRRGLRFWGPEGVLEHLLLPVLREVGEAWHRGEIGVAEEHLASTFLRARLQELLDLAGFPPGPPVLVTTPPGERHEIGAMLAAYHLRRKGVPALYLGPDTPLPDLRALARRLGAGAVVLSAVLSEPLRALPDGALKDLAPRVFLGGQGAGPEEARRLGAEYMEDLKGLAEALWLPRGPEKEAI
InterPro domains: - IPR006158: Cobalamin (vitamin B12)-binding domain (domain) [164-285]
- IPR000551: MerR-type HTH domain (domain) [6-77]
- IPR047057: MerR transcriptional regulator (family) [3-155]
- IPR009061: Putative DNA-binding domain superfamily (homologous_superfamily) [7-75]
- IPR003759: Cobalamin (vitamin B12)-binding module, cap domain (domain) [86-155]
- IPR036594: Methionine synthase domain (homologous_superfamily) [81-159]
- IPR036724: Cobalamin-binding domain superfamily (homologous_superfamily) [162-248]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Pentatricopeptide repeat-containing protein At1g51965, mitochondrial (Q9ZU27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000305|PubMed:25732537}.
Sequence: MKLLRRRFFNSVNTITRPNRRHYATKYVAKVTSSSPSGRSLSAEVSLPNPLPADVRGYPLPRRHLICRATNLITGASNLSDAFSDLSDYLSSLSLSLTPDEASEILKSLNSPLLAVEFFKLVPSLCPYSQNDPFLYNRIILILSRSNLPDRFDRVRSILDSMVKSNVHGNISTVNILIGFFGNTEDLQMCLRLVKKWDLKMNSFTYKCLLQAYLRSRDYSKAFDVYCEIRRGGHKLDIFAYNMLLDALAKDEKACQVFEDMKKRHCRRDEYTYTIMIRTMGRIGKCDEAVGLFNEMITEGLTLNVVGYNTLMQVLAKGKMVDKAIQVFSRMVETGCRPNEYTYSLLLNLLVAEGQLVRLDGVVEISKRYMTQGIYSYLVRTLSKLGHVSEAHRLFCDMWSFPVKGERDSYMSMLESLCGAGKTIEAIEMLSKIHEKGVVTDTMMYNTVFSALGKLKQISHIHDLFEKMKKDGPSPDIFTYNILIASFGRVGEVDEAINIFEELERSDCKPDIISYNSLINCLGKNGDVDEAHVRFKEMQEKGLNPDVVTYSTLMECFGKTERVEMAYSLFEEMLVKGCQPNIVTYNILLDCLEKNGRTAEAVDLYSKMKQQGLTPDSITYTVLERLQSVSHGKSRIRRKNPITGWVVSPL
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [109-626]
- IPR002885: Pentatricopeptide repeat (repeat) [202-617]
Interaction partners: - RCC1 domain-containing protein RUG3, mitochondrial
- NADH dehydrogenase subunit 2.
- NADH-ubiquinone oxidoreductase chain 2
- Transmembrane 9 superfamily member 4
- Nuclear intron maturase 1, mitochondrial
- DEAD-box ATP-dependent RNA helicase 53, mitochondrial
- Transcription termination factor MTERF15, mitochondrial
- RNA helicase
- Nuclear intron maturase 4, mitochondrial
- Nuclear intron maturase 2, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Alpha/beta hydrolase domain-containing protein 17A (Abhydrolase domain-containing protein 17A) (EC 3.1.2.22) (Q96GS6)
Organism: Homo sapiens (Human)
Function: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towards MAP6 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:26701913}. Endosome membrane {ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:26701913}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5XIJ5}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q5XIJ5}.
Sequence: MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARYTVLFSHGNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSERNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRA
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [68-306]
- IPR022742: Serine aminopeptidase, S33 (domain) [111-216]
Interaction partners: - Acyl-protein thioesterase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0098599 (palmitoyl hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008474 (palmitoyl-(protein) hydrolase activity), GO:0016790 (thiolester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0043412 (macromolecule modification), GO:1901565 (organonitrogen compound catabolic process), GO:0042157 (lipoprotein metabolic process), GO:0030163 (protein catabolic process), GO:0098732 (macromolecule deacylation), GO:0042159 (lipoprotein catabolic process), GO:0035601 (protein deacylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: T. brucei spp.-specific protein (Q38D15)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MWFIAPTPFALKHRCPAIVLGGFSLTAAVCCEVVALKQRRYIVKILKKGNSGAFSCSCILIGTLRWWPMALLVRGRYHEVTKKILKRQKGEKGKIFCHCATADAMILHESPHHYCKWAARGGSEDWDYSNSFVVVCAVLLENIATNEREGECHLTFHAATSTHHDYMLVALRGKVVKAKVSFRFKEV
InterPro domains: - IPR009566: Protein of unknown function DUF1181 (family) [96-187]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein BTG3 (rBTG3) (BTG family member 3) (O88677)
Organism: Rattus norvegicus (Rat)
Function: Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
Sequence: MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKNHWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACEDSCILYSDLGLPKELTLWVDPCEVCCRYGKKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVEVKPSAVATTPSPVYQISELIFPPLPMWHPLPRKKPGMYRGGGHQSHYPPPVPFAYPSPGRKNKAFRPIPVTWVPPPGMHCDRNHWINPHMLAPH
InterPro domains: - IPR033332: BTG family (family) [1-223]
- IPR036054: BTG-like domain superfamily (homologous_superfamily) [1-124]
- IPR002087: Anti-proliferative protein (domain) [1-120]
Interaction partners: - CCR4-NOT transcription complex, subunit 7.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0010717 (regulation of epithelial to mesenchymal transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)