Protein: N-acylneuraminate cytidylyltransferase A (EC 2.7.7.43) (CMP-sialic acid synthetase 1) (Q0E671)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Also has activity towards N-glycolylneuraminic acid (Neu5Gc). Has weak activity towards 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
Subcellular location: Nucleus {ECO:0000269|PubMed:22351762}.
Sequence: MDAVNENGKRAMKDDSHGNSTSPKRRKSRHISALILARGGSKGIPLKNIKMLAGVPLIGWVIRAAVDSNVFNSVWVSTDHEEIAKVALAWGAKVHKRSPEVSQDSSSSLDTIREFSRQHREVDVICNIQATSPCLHPKHLTEAVELITKQGYDSVFSVVRRHNFRWKEVEKGGDCSTEPMNLNPACRPRRQDWSGELCENGSFYFAKKELIEQGLLQGGKKTYYEMKPEYSVDIDVDIDWPVAEQRVLRFGYFGKDKPEVVRLLLCNVSGCLTDGQIYTSASGEEMVSINIRDQIGISMLKKEGVKVILLETYPIAKALAVRLSERMGCPLLHHMDDKLKEVERIMVEEKLEWKEVAYLGNDEADVKCLELAGLSGVPVDAPTVALNHTKYTCHNAAGHGAVREFAEHILLLKKKAKSQMEQDRICRDAF
InterPro domains: - IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [29-255]
- IPR003329: Acylneuraminate cytidylyltransferase (family) [33-243]
- IPR036412: HAD-like superfamily (homologous_superfamily) [261-416]
- IPR050793: CMP-NeuNAc synthase (family) [22-415]
- IPR023214: HAD superfamily (homologous_superfamily) [256-422]
Interaction partners: - N-acetylneuraminic acid synthase a.
- Cytidine monophosphate-N-acetylneuraminic acid hydroxylase
- N-acetylneuraminic acid phosphatase.
- N-acetylneuraminic acid synthase b.
- exo-alpha-sialidase
- Uncharacterized protein
- exo-alpha-sialidase
- Alpha-2,8-sialyltransferase 8E
- Sialidase-1
- Inorganic pyrophosphatase 1a.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070567 (cytidylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)