Protein: Neuronal acetylcholine receptor subunit alpha-4 (O70174)
Organism: Mus musculus (Mouse)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Subcellular location: Synaptic cell membrane {ECO:0000305|PubMed:12944511}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000305|PubMed:12944511}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MEIGGSGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDICNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIKARSLSVQHVPSSQEAAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTSPCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [251-626]
- IPR006201: Neurotransmitter-gated ion-channel (family) [34-621]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [29-250]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [163-177]
- IPR002394: Nicotinic acetylcholine receptor (family) [73-161]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [245-624]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [252-620]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [39-244]
Interaction partners: - Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-6
- Neuronal acetylcholine receptor subunit alpha-5
- Acetylcholine receptor subunit gamma
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit delta
- Tyrosine-protein kinase JAK2
- Syntaxin-binding protein 5
- Neuronal acetylcholine receptor subunit beta-3
- Acetylcholine receptor subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0042165 (neurotransmitter binding), GO:0050997 (quaternary ammonium group binding), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0022803 (passive transmembrane transporter activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015464 (acetylcholine receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022848 (acetylcholine-gated monoatomic cation-selective channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0009628 (response to abiotic stimulus), GO:0065008 (regulation of biological quality), GO:0009314 (response to radiation), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0051899 (membrane depolarization), GO:0006811 (monoatomic ion transport), GO:0009416 (response to light stimulus), GO:0006812 (monoatomic cation transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0043235 (receptor complex), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:1990351 (transporter complex), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:1902495 (transmembrane transporter complex), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0034702 (ion channel complex), GO:0005892 (acetylcholine-gated channel complex), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0032279 (asymmetric synapse)