Protein: E3 ubiquitin-protein ligase (B7Z078)
Organism: Drosophila melanogaster (Fruit fly)
Function: E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated proteins and mediates their ubiquitination and subsequent degradation
Subcellular location: Cytoplasm, cytosol
Sequence: MSQQRSTEQIAASNNNTSDVIALDDDEDTDVQFVAALRPTAPVIDLCVSPSTSAAAAAAAAAAAHSGGGSGEDPAVGSASGAAASDTDSLASSPDEGALATGVDAAAAVSGEDSPSAAAAALECPICLQTCIHPARLPCGHIFCFLCVKGVAYKNRRCAMCRREIPAEFLDHPQLVNGIEDICTTRATEDGFQWYYEGRNGWWQYDDRTSQDIEDAFKKGDKSCTILVAGYVYIVDLEQLVQQRQNEPTRCRRVKRDLATIPKKGVAGLRIEGNQVTSDTVFSRPTNTANPTTVAAAASSFISTIAATDAAIRIASDIIGSTLAHADELTRGLTASNLNDDLSSSGEQSNSTNSNDAGRSPASSPASSSMQDLITRDLRNTQQVIAHNQHTIDLFEQALNDFQALAMRNYVDSSDEENNDQDQEHELREREQLEAGEQPQSNDNPQRF
InterPro domains: - IPR044110: RNF146, RING finger, HC subclass (domain) [122-171]
- IPR004170: WWE domain (domain) [180-256]
- IPR001841: Zinc finger, RING-type (domain) [124-162]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [139-148]
- IPR037197: WWE domain superfamily (homologous_superfamily) [163-272]
- IPR018123: WWE domain, subgroup (domain) [189-264]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [99-186]
- IPR033509: E3 ubiquitin-protein ligase RNF146 (family) [114-279]
Interaction partners: - Poly [ADP-ribose] polymerase tankyrase
- Axin
- Poly [ADP-ribose] polymerase
- Ankyrin, isoform B
- Ankyrin 2, isoform U
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0009967 (positive regulation of signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0009966 (regulation of signal transduction), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031647 (regulation of protein stability), GO:0009896 (positive regulation of catabolic process), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0030111 (regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0031329 (regulation of cellular catabolic process), GO:0031648 (protein destabilization), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0090263 (positive regulation of canonical Wnt signaling pathway), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)