Protein: Polycomb protein Su(z)12 (Suppressor 12 of zeste protein) (Q9NJG9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
Subcellular location: Nucleus {ECO:0000305|PubMed:22354997}. Chromosome {ECO:0000269|PubMed:22354997}.
Sequence: MAPAKKREKDSNPDGSAANGIIGLTHGAPDASNAGSTVPPTAEGQVKLNGHQQEQELFLQAFEKPTQIYRYLRNRHETNPIFLNRTLSYMKERMSRNNKKRISFQVNSMLESITQKSEAVSQNYLHVIYDSLHEKLPARLDNESGEDLLQEQLLCEAGESVSVETTLYKITRSKRKDSTLDFQELLSKCSQIVYNPKDRVGEHATISIPLQTMRPMGEQHTLYKLLFRIKVLSPSTCNDENAETPPNKRSRPNEKMFGSELILYEKSSGFITEGEYEAMLQPLNSTSIKSFSPKKCTWETMPDSYIPLSLTYDVYQQSPMLKFHLTLSNEQLPEMISAPELQRYVQHLDAVAEMNYNNNNYNNNNNCSGLKNGSGGGNSTVCKTTPEHIQIVYNFMYSNNTRQQTEYTQELNCPWCGLDCLRLYALLKHLKLCHARFNFTYQPAGSGARIDVTINDAYDGSYAGSPYDLAGPSGSSFARTCGPVRRTSVTSLMVCRPRRQKTCLDEFLELDEDEISNQRSYITGHNRLYHHTETCLPVHPKELDIDSEGESDPLWLRQKTIQMIDEFSDVNEGEKELMKLWNLHVMRHGFVGDCQLPIACEMFLDAKGTEIVRKNLYRNFILHMCSLFDYGLIAAETVYKTVQKLQGLLSKYAAGQELMQRQREEQLKYWLDVGMHKKQEDPKTLKSPQKPAPPADQASTSSASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDNTVLNKRQRYSDGSPGTGIGNGHGGGSGSGANRNKSNNHSLPATSNNASSSSSNSKRAIARRRSTSERTKASGSTGGGAGGVRTRLSVPAKYERR
InterPro domains: - IPR057540: Polycomb protein SUZ12-like, zinc finger domain (domain) [390-456]
- IPR019135: Polycomb protein, VEFS-Box (domain) [512-643]
Interaction partners: - Polycomb protein esc
- Polycomb protein esc
- Histone-lysine N-methyltransferase E
- Chromatin assembly factor 1 p55 subunit
- Zinc finger protein jing
- E3 ubiquitin-protein ligase RING1
- Histone deacetylase HDAC1
- Polycomb group protein Psc
- Jumonji, AT rich interactive domain protein 2
- Polycomb group protein Pc
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0005102 (signaling receptor binding), GO:0004857 (enzyme inhibitor activity), GO:0008047 (enzyme activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009791 (post-embryonic development), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:1901564 (organonitrogen compound metabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0035107 (appendage morphogenesis), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009887 (animal organ morphogenesis), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:1901185 (negative regulation of ERBB signaling pathway), GO:0045664 (regulation of neuron differentiation), GO:0051246 (regulation of protein metabolic process), GO:0035120 (post-embryonic appendage morphogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0048707 (instar larval or pupal morphogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0030111 (regulation of Wnt signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0048737 (imaginal disc-derived appendage development), GO:0048569 (post-embryonic animal organ development), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0010467 (gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0009952 (anterior/posterior pattern specification), GO:0042058 (regulation of epidermal growth factor receptor signaling pathway), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0007472 (wing disc morphogenesis), GO:0070647 (protein modification by small protein conjugation or removal), GO:0019220 (regulation of phosphate metabolic process), GO:0035220 (wing disc development), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0045936 (negative regulation of phosphate metabolic process), GO:0043409 (negative regulation of MAPK cascade), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0043407 (negative regulation of MAP kinase activity), GO:0045859 (regulation of protein kinase activity), GO:0016579 (protein deubiquitination), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity), GO:0043405 (regulation of MAP kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)