Protein: A-kinase anchor protein 7 isoform gamma (AKAP-7 isoform gamma) (A-kinase anchor protein 18) (AKAP-18) (Protein kinase A-anchoring protein 7 isoform gamma) (PRKA7 isoform gamma) (Q7TN79)
Organism: Mus musculus (Mouse)
Function: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:12804576}. Cytoplasm {ECO:0000269|PubMed:12804576}. Note=In oocytes, localizes to the nucleus, to germinal vesicles and throughout the cytoplasm. {ECO:0000269|PubMed:12804576}.
Sequence: MPFAAVDIQDDCGSPDVPQANPKRSKEEEEDRGDKNDHVKKRKKAKKDYQPNYFLSIPITNKKITTGIKVLQNSILQQDKRLTKAMVGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKHLALPFQGIGTFQGQVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRTFKPHLTFMKLSKAPMLRKKGVRKIEPGLYEQFIDHRFGEELLYQIDLCSMLKKKQSNGYYHCESSIVIGEKDRREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDNNRK
InterPro domains: - IPR019511: A-kinase anchor protein 7, RI-RII subunit-binding domain (domain) [255-311]
- IPR019510: A-kinase anchor protein 7-like, phosphoesterase domain (domain) [51-248]
- IPR052641: A-kinase anchor protein 7 isoform gamma (family) [20-313]
- IPR009097: Cyclic phosphodiesterase (homologous_superfamily) [52-250]
Interaction partners: - cAMP-dependent protein kinase type II-alpha regulatory subunit
- cAMP-dependent protein kinase catalytic subunit alpha
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Voltage-dependent L-type calcium channel subunit alpha-1C
- 3',5'-cyclic-AMP phosphodiesterase 4D
- A-kinase anchor protein 1, mitochondrial
- Superoxide dismutase, mitochondrial
- Small ribosomal subunit protein mS29
- Endoribonuclease YbeY
- Small ribosomal subunit protein uS17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0051018 (protein kinase A binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0051179 (localization), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051641 (cellular localization), GO:0050794 (regulation of cellular process), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0008104 (protein localization), GO:0010738 (regulation of protein kinase A signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)