Protein: LIM domain-binding protein 1-A (LDB-1-A) (LIM domain-binding protein 4) (LDB-4) (zLdb4) (O73715)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
Subcellular location: Nucleus {ECO:0000269|PubMed:16815859}.
Sequence: MLDRDVGPTPMYPPSYMEPGIGRHTPYGNQTDYRIFELNKRLQNWTEQDCDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELFYVLKHPKESFHNNFVSLDCDQCTMVTQNGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHREVVPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQAPNKRRKRKMSGGSTMSSGGGNNNNSNSKKKSPASSFALSSQDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNSSPTMGTNSPWNSKAPSSQQGKNDNPSSQSSQ
InterPro domains: - IPR041363: LIM interaction domain (domain) [299-338]
- IPR029005: LIM-domain binding protein/SEUSS (family) [31-367]
Interaction partners: - T-cell acute lymphocytic leukemia protein 1 homolog
- Rhombotin-2
- Rhombotin-1
- Endothelial transcription factor GATA-2a
- Single-stranded DNA-binding protein 2
- Single-stranded DNA-binding protein 4
- BHLH domain-containing protein.
- LIM/homeobox protein Lhx3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0019222 (regulation of metabolic process), GO:0042303 (molting cycle), GO:0022404 (molting cycle process), GO:0050794 (regulation of cellular process), GO:0098727 (maintenance of cell number), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0019827 (stem cell population maintenance), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0048522 (positive regulation of cellular process), GO:0001817 (regulation of cytokine production), GO:0048872 (homeostasis of number of cells), GO:0051726 (regulation of cell cycle), GO:0090068 (positive regulation of cell cycle process), GO:0042633 (hair cycle), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0009880 (embryonic pattern specification), GO:0060249 (anatomical structure homeostasis), GO:0009891 (positive regulation of biosynthetic process), GO:0044087 (regulation of cellular component biogenesis), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0070316 (regulation of G0 to G1 transition), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0051249 (regulation of lymphocyte activation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)