Protein: Ubiquitin receptor RAD23c (AtRAD23c) (Putative DNA repair protein RAD23-3) (RAD23-like protein 3) (AtRAD23-3) (Q84L31)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in nucleotide excision repair (By similarity). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).
Subcellular location: Nucleus {ECO:0000269|PubMed:20086187}. Cytoplasm {ECO:0000269|PubMed:20086187}.
Sequence: MKIFVKTLKGTHFEIEVKPEDSVVDVKKNIESVQGADVYPAAKQMLIHQGKVLKDETTIEENKVAENSFIVIMMNKSKPASAAASSASAGTSQAKSIPPSTSQPSISPQTPASVSAPVAPAPTRPPPPAPTPTPAPVAATETVTTPIPEPVPATISSSTPAPDSAPVGSQGDVYGQAASNLAAGSNLESTIQQILDMGGGTWDRETVVLALRAAFNNPERAVEYLYTGIPEQAEVPPVARPPASAGQPANPPAQTQQPAAAPASGPNANPLDLFPQGLPNVGGNPGAGTLDFLRNSQQFQALRAMVQANPQVLQPMLQELGKQNPNLMRLIQDHQADFLRLINEPVEGGGESGNLLGQMAAGMPQPQAIQVTHEEREAIERLEAMGFERALVLEVFFACNKNEELAANYLLDHMHEFEE
InterPro domains: - IPR015940: Ubiquitin-associated domain (domain) [185-413]
- IPR000626: Ubiquitin-like domain (domain) [1-79]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-88]
- IPR004806: UV excision repair protein Rad23 (family) [1-418]
- IPR015360: XPC-binding domain (domain) [290-345]
- IPR009060: UBA-like superfamily (homologous_superfamily) [184-417]
- IPR036353: XPC-binding domain superfamily (homologous_superfamily) [282-353]
- IPR006636: Heat shock chaperonin-binding (domain) [288-331]
Interaction partners: - 26S proteasome non-ATPase regulatory subunit 4 homolog
- DNA repair protein RAD4
- Peptide-N
- Probable ubiquitin conjugation factor E4
- 26S proteasome regulatory subunit RPN13
- Ubiquitin domain-containing protein DSK2b
- Protein DNA-DAMAGE INDUCIBLE 1
- Protein NBR1 homolog
- Calcium-binding protein CML19
- Ubiquitin domain-containing protein DSK2a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0070628 (proteasome binding), GO:0032182 (ubiquitin-like protein binding), GO:0140030 (modification-dependent protein binding), GO:0031593 (polyubiquitin modification-dependent protein binding), GO:0043130 (ubiquitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0033554 (cellular response to stress), GO:0010286 (heat acclimation), GO:0034605 (cellular response to heat), GO:0070370 (cellular heat acclimation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)