Protein: PDZ and LIM domain protein 7 (Q6P7E4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Sequence: MNIYCVTLNGPAPWGFRLQGGKDFNTPLTVSRLTPGGKAAQAGVGVGDWVVSIFDANAEEMTHVEAQNKIRAATDSLKLTLSRAFHPAGGEQKDSLTSSSSQPKYSFAPSTAINKMARPFSASPGSGSAGPVIKPVSYALKPALSSPHNGHGVAPCPVTVKSKPADKHDAVQAPAKAPVSSGPACRPPWVTDPGFADRYHPDKSSTVVTQHTQPLQPTPMQNRSSILQAAQQSPAHSSTATPLCAACSKIIRGRYVVALGRSWHPEEFMCCQCKRLLDEGGFFEEKGSIYCSKCYDNRYSPNCAKCKKIITGEIMHALKMTYHVQCFLCAACKLPIRNQAFYMEEGEPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGYSWHDTCFVCAICQINLEGKTFYSKKDKPLCKSHAFSPL
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [1-99]
- IPR050604: PDZ and LIM domain-containing (family) [173-416]
- IPR001478: PDZ domain (domain) [9-85]
- IPR001781: Zinc finger, LIM-type (domain) [242-419]
Interaction partners: - T-box transcription factor 4
- GAS2-like protein 3
- Actinin alpha 3b
- T-box transcription factor TBX5-A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0140297 (DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0046907 (intracellular transport), GO:0044092 (negative regulation of molecular function), GO:0060341 (regulation of cellular localization), GO:0006810 (transport), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051169 (nuclear transport), GO:0032880 (regulation of protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0006913 (nucleocytoplasmic transport), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0031941 (filamentous actin), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032432 (actin filament bundle), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0042641 (actomyosin), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0097517 (contractile actin filament bundle), GO:0001725 (stress fiber), GO:0099081 (supramolecular polymer), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0030864 (cortical actin cytoskeleton), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton), GO:0005884 (actin filament)