Protein: Elongation factor 1-alpha 1 (EF-1-alpha 1) (eEF-1A1) (P0DH99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm.
Sequence: MGKEKFHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKARYDEIIKEVSSYLKKVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLEALDQINEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGMIKPGMVVTFAPTGLTTEVKSVEMHHESLLEALPGDNVGFNVKNVAVKDLKRGYVASNSKDDPAKGAANFTSQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFSEILTKIDRRSGKEIEKEPKFLKNGDAGMVKMTPTKPMVVETFSEYPPLGRFAVRDMRQTVAVGVIKSVDKKDPTGAKVTKAAVKKGAK
InterPro domains: - IPR050100: Translation factor GTPase superfamily members (family) [2-433]
- IPR004161: Translation elongation factor EFTu-like, domain 2 (domain) [248-313]
- IPR004539: Translation elongation factor EF1A, eukaryotic/archaeal (family) [1-433]
- IPR054696: GTP-eEF1A, C-terminal domain (domain) [327-427]
- IPR000795: Translational (tr)-type GTP-binding domain (domain) [5-230]
- IPR009001: Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (homologous_superfamily) [326-430]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-249]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [226-321]
- IPR031157: Tr-type G domain, conserved site (conserved_site) [61-76]
Interaction partners: - Probable elongation factor 1-gamma 2
- GTP-binding nuclear protein Ran-2
- GTP-binding nuclear protein Ran-3
- GTP-binding nuclear protein Ran-1
- GTP-binding nuclear protein Ran-4
- Elongation factor 1-delta 2
- Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic
- Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic
- Elongation factor 1-beta 1
- Glyceraldehyde-3-phosphate dehydrogenase GAPCP1, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0009791 (post-embryonic development), GO:0099402 (plant organ development), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0043207 (response to external biotic stimulus), GO:0090567 (reproductive shoot system development), GO:0048731 (system development), GO:0009617 (response to bacterium), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0044249 (cellular biosynthetic process), GO:0048608 (reproductive structure development), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0098542 (defense response to other organism), GO:1901566 (organonitrogen compound biosynthetic process), GO:0048367 (shoot system development), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0061458 (reproductive system development), GO:0006518 (peptide metabolic process), GO:0042742 (defense response to bacterium), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0009908 (flower development), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0055044 (symplast), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0005773 (vacuole), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005911 (cell-cell junction)