Protein: Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10) (Q8CFR0)
Organism: Mus musculus (Mouse)
Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.
Subcellular location: Secreted {ECO:0000269|PubMed:18783346}.
Sequence: MALGLLIAVPLLLQAAPPGAAHYEMLGTCRMICDPYSVAPAGGPAGAKAPPPGPSTAALEVMQDLSANPPPPFIQGPKGDPGRPGKPGPRGPPGEPGPPGPRGPPGEKGDSGRPGLPGLQLTTSAAGGVGVVSGGTGGGGDTEGEVTSALSAAFSGPKIAFYVGLKSPHEGYEVLKFDDVVTNLGNHYDPTTGKFSCQVRGIYFFTYHILMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVVLHLDSGDEVYVKLDGGKAHGGNNNKYSTFSGFLLYPD
InterPro domains: - IPR050822: Cerebellin Synaptic Organizer (family) [27-287]
- IPR001073: C1q domain (domain) [152-287]
- IPR008983: Tumour necrosis factor-like domain superfamily (homologous_superfamily) [152-287]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0003008 (system process), GO:0007610 (behavior), GO:0048468 (cell development), GO:0007611 (learning or memory), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0050877 (nervous system process), GO:0051128 (regulation of cellular component organization), GO:0071695 (anatomical structure maturation), GO:0050890 (cognition), GO:0022008 (neurogenesis), GO:0042551 (neuron maturation), GO:0007399 (nervous system development), GO:0050807 (regulation of synapse organization), GO:0043954 (cellular component maintenance), GO:0007612 (learning), GO:0034330 (cell junction organization), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048699 (generation of neurons), GO:0016322 (neuron remodeling), GO:0050808 (synapse organization), GO:0034331 (cell junction maintenance), GO:0099558 (maintenance of synapse structure)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0042995 (cell projection), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0043083 (synaptic cleft), GO:0043005 (neuron projection), GO:0060076 (excitatory synapse), GO:0098984 (neuron to neuron synapse), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0030424 (axon), GO:0098985 (asymmetric, glutamatergic, excitatory synapse)