Protein: 1-phosphatidylinositol 3-phosphate 5-kinase (B2KTE4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein
Sequence: MAADDKASSSSSVMDWSSEPPPSPTSPSHLTHFKPLTPEQDEPPLRSAYSSFVSLFRFNKEEGRPPSVTEKSQSASSSPQGPRRNWSSPSHSIHGSETHRKHPELLRRTSAASEGRRKSEAPLGSHDPRTAVQLRTALKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCNEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSSSIGEDLSALSDSPCSVCVLEPTEPRTPVGGRKASRNIFLEEDLAWQSHQESQNSGLNSRLTVVQEDIGKSPARKRSASVTNLSLDRSGSSMVPAYESSVSPQNSRALPKTDHSEEERKILLDSFQLKDIWKKICHNTTGMEFQDHRYWLRTYPNCIVGKELVNWLLRNGTISTRAQAIAIGQALVDGRWLDCVTHHDQIFRDEYALYRPLQSTEFSETPSPDSDSVNSLEGHSEPSWFKDIKFDDSDTEQLADENDYVTPSSSSPSKRTSVSSFHSAVDSDSAASISLNMEQDNVNFHIKKQAKYPHVPPYPAEQKMEVLLSEDGGQHISISDAFIKESLFNRRVEEKAKEMLFTPLGWHHSSLDQLREENGEKKAMERLLSANHSHMMALLQQLLYSESLSLSWRDIIVPVVRQVVQTVRPDVRSCDDDMDIRQFVHIKKIPGGKKFDSAVVNGFVCTKNIAHKKMNSYIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPNLVLVEKTVSRIAQDMLLEHGIAIVINVKPQVLDRVSRMTQGDLVISMDQLLTKPRLGTCHKFYLHSFQLPNSEVKTLMFFEGCPPQLGCTIKLRGASEYELARVKEIIIFMVCVAYHSQLEISFLMDEFAMPPSLAESSSFPCLLESTTLREEDETSGERESQDNDESTLGDDNLTLVPGDDFETGFTGTIKAHSREPSTSESSHKDGESPRINKNASITSFSGGEEENIKTSTPLSSFSSTFPQPVTPPFLISDVKEMSQEVVKGSGEGEKNKYLESTLVHQDSTSSETSLPPTRLFRDPLQDDTGLFVTEHVASSDDRLKSISALFKQELKDIILCISPFITFREPFLLTPAGLRCPSRDYFPEQVYLSPLLNKDSKELDGRRKRQLLKESSPGSGSLTNGSVSHQRAIQILPCHKLTSARIAEQVGSSQQLARMLADYRAQGGRIRQREGTQFREAPPPKAPIKADSEEDKGAGVIDMTWSTKLDCLNPINHQRLCVLFSSSSAQSNNAPNPCVSPWIVTMEFYGKNDLTLGVFLERYCFRPSYQCPSMYCETPMVHHIRRFVHGKGCVQIVLKELDSPVPGYQHTILNYSWCRICKQVTPVVPLSNDSWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHKDYHQYFSYNQMVASFSYIPVRLLEICLPPPKIIIRNQGPSKSSLQQDLKDFSQKVAQVYLAIDDRLTSLKTDTFSKTREEKMEDMFAQKDMEESELRGWIEKLQVRLQTSVIDSSQQLQAVLESVVVKKQGLCETLQSWNNRLQELFQQEKGRKRLSVPPSPGRHRQPTTDESKTSALESSPRNPSPVVPNGDKEDRHLNTFPSSSGSSSLLQLPSPAEQPSDVITSGPSFPDQDSVSNPEDMFDGHLLGSNDSQVKEKSTMKTILANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEREPSSIIAFALSCKEYKTALEELTKTTAKTGGDDTSQTISAGESRVKNSPAKPSDNSMSQLSRSSVDADPLKEPESADKQKKQTGNPHIELQFSDANAKFYCRIYYAEEFHKMREEIMESTEDDFVRSLSHCVNWQARGGKSGAVFYATEDDRFILKQMPRLEVQSFLDFAPHYFTYITGAVHLKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDQGKESCEVVLLDENLLKLVHDNPLYIRSHCKAILRAAIHSDALFLSSHLIIDYSLLVGRDDSTDELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWSGLGLNC
InterPro domains: - IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [157-229]
- IPR000591: DEP domain (domain) [366-441]
- IPR002498: Phosphatidylinositol-4-phosphate 4/5-kinase, core (domain) [1738-2062]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [678-845]
- IPR027483: Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily (homologous_superfamily) [1918-2062]
- IPR000306: FYVE zinc finger (domain) [153-222]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [353-490]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [613-858]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [353-483]
- IPR037378: PIKfyve, DEP domain (domain) [358-439]
- IPR027484: Phosphatidylinositol-4-phosphate 5-kinase, N-terminal (homologous_superfamily) [1752-1916]
- IPR043548: 1-phosphatidylinositol-3phosphate-5-kinase (family) [1-2075]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [145-222]
- IPR044769: 1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain (domain) [1795-2061]
- IPR017455: Zinc finger, FYVE-related (domain) [161-221]
Interaction partners: - Protein VAC14 homolog
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol 4-kinase type 2-alpha
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8
- Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Phosphatidylinositol-3-phosphatase SAC1-A
- Phosphatidylinositol-3-phosphatase SAC1-B
- Phosphatidylinositol 4-kinase type 2-beta
- Myotubularin-related protein 14
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0016307 (phosphatidylinositol phosphate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0008045 (motor neuron axon guidance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0016020 (membrane)