Protein: receptor protein serine/threonine kinase (EC 2.7.11.30) (A0A0B4K7J3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MESNIYLVFLLTFLLYNNARAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRHIKSKRRMKRRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGCSTSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCNEGDFPELLPFDSNDVTVITADTSSISKMLVAVLGPFLVIALLGAVTIFFIRRSHRKRLAASRTKQDPEAYLVNDELLRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKLASADEKIRLDFDEVCV
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [251-561]
- IPR003605: GS domain (domain) [246-276]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [400-412]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [277-559]
- IPR017441: Protein kinase, ATP binding site (binding_site) [282-303]
- IPR000719: Protein kinase domain (domain) [276-567]
- IPR000472: Activin types I and II receptor domain (domain) [77-162]
- IPR000333: Ser/Thr protein kinase, TGFB receptor (family) [72-568]
- IPR045860: Snake toxin-like superfamily (homologous_superfamily) [73-180]
Interaction partners: - Protein decapentaplegic
- receptor protein serine/threonine kinase
- Protein screw
- Protein 60A
- Serine/threonine-protein kinase receptor
- Protein mothers against dpp
- Inhibin beta chain
- Mothers against decapentaplegic homolog
- receptor protein serine/threonine kinase
- Maverick
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0002682 (regulation of immune system process), GO:0051301 (cell division), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0048583 (regulation of response to stimulus), GO:0098727 (maintenance of cell number), GO:0006950 (response to stress), GO:0019827 (stem cell population maintenance), GO:0048609 (multicellular organismal reproductive process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0007276 (gamete generation), GO:0050777 (negative regulation of immune response), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007281 (germ cell development), GO:0007552 (metamorphosis), GO:0009798 (axis specification), GO:0030718 (germ-line stem cell population maintenance), GO:0043207 (response to external biotic stimulus), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0035107 (appendage morphogenesis), GO:0042078 (germ-line stem cell division), GO:0009880 (embryonic pattern specification), GO:0098542 (defense response to other organism), GO:0031348 (negative regulation of defense response), GO:0002831 (regulation of response to biotic stimulus), GO:0009887 (animal organ morphogenesis), GO:0050776 (regulation of immune response), GO:0003002 (regionalization), GO:0009617 (response to bacterium), GO:0009790 (embryo development), GO:0009886 (post-embryonic animal morphogenesis), GO:0002832 (negative regulation of response to biotic stimulus), GO:0017145 (stem cell division), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0035282 (segmentation), GO:0045088 (regulation of innate immune response), GO:0035120 (post-embryonic appendage morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0045824 (negative regulation of innate immune response), GO:0007350 (blastoderm segmentation), GO:0009948 (anterior/posterior axis specification), GO:0007447 (imaginal disc pattern formation), GO:0048737 (imaginal disc-derived appendage development), GO:0042742 (defense response to bacterium), GO:0048569 (post-embryonic animal organ development), GO:0000578 (embryonic axis specification), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0007351 (tripartite regional subdivision), GO:0009952 (anterior/posterior pattern specification), GO:0007472 (wing disc morphogenesis), GO:0007448 (anterior/posterior pattern specification, imaginal disc), GO:0035220 (wing disc development), GO:0008595 (anterior/posterior axis specification, embryo), GO:0050829 (defense response to Gram-negative bacterium), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0008358 (maternal determination of anterior/posterior axis, embryo)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0043235 (receptor complex), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:1990234 (transferase complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0005886 (plasma membrane), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex)