Protein: Helix-loop-helix 34 (P90953)
Organism: Caenorhabditis elegans
Function: Transcription factor (By similarity). Involved in specifying AVH neuron identity, acting in concert with unc-42. Involved in serotonin-mediated feeding behavior, probably acting by modulating expression of genes involved in glutamate signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Sequence: METNLSEEKQKPSKSQAQQRRQMENYEFSQLANELPLARAISGQHIDKTTMVRLATAYIKLHNIFGQSQRAYSSADYYYGSDSLWTNNHLDLLDGFFVILDRRGDVLYISETISIYLGLSQVEMTGNAMVDYIHEQDINCFNSALNYCDLNWPQMCNVRVKSSLTKRANKDAVRASPGYKVLRLEITMGPNTNTRMIACYPMPTPVLSTVTIPSNSFVIITSIDLHITFADEKAHQLLNNPFYPDSNIKGMSLYSLIDISDSEVISKMHFDIFNLGAYKTPYYRMILNQTSETFYVESNIFRHTSISSKQFNDSITFVSSIL
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [6-64]
- IPR035965: PAS domain superfamily (homologous_superfamily) [93-144]
- IPR000014: PAS domain (domain) [84-305]
- IPR013767: PAS fold (domain) [90-137]
Interaction partners: - Aryl hydrocarbon receptor nuclear translocator homolog
- PAS domain-containing protein cky-1
- xanthine dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0008340 (determination of adult lifespan), GO:0042221 (response to chemical), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0007610 (behavior), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0050795 (regulation of behavior), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0060259 (regulation of feeding behavior), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1903998 (regulation of eating behavior), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0043051 (regulation of pharyngeal pumping), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)