Protein: Cerebellin-3 (Q9JHG0)
Organism: Mus musculus (Mouse)
Function: May be involved in synaptic functions in the CNS.
Subcellular location: Endoplasmic reticulum. Golgi apparatus, cis-Golgi network. Secreted. Synapse. Note=In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2.
Sequence: MGTEWHKPKLSLALVLLTLEAGWAQEGSEPVLLEGECLVVCEPGRPTAGGPGGAALGEAPPGRVAFAAVRSHHHEPAGETGNGTSGAIYFDQVLVNEGEGFDRTSGCFVAPVRGVYSFRFHVVKVYNRQTVQVSLMLNTWPVISAFANDPDVTREAATSSVLLPLDPGDRVSLRLRRGNLLGGWKYSSFSGFLIFPL
InterPro domains: - IPR050822: Cerebellin Synaptic Organizer (family) [62-196]
- IPR001073: C1q domain (domain) [57-197]
- IPR008983: Tumour necrosis factor-like domain superfamily (homologous_superfamily) [62-197]
Interaction partners: - Gamma-aminobutyric acid receptor subunit alpha-6
- Glutamate receptor ionotropic, delta-2
- Protein NYNRIN
- Coiled-coil domain-containing protein 137
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0099536 (synaptic signaling), GO:2000026 (regulation of multicellular organismal development), GO:0044085 (cellular component biogenesis), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0099177 (regulation of trans-synaptic signaling), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:1901890 (positive regulation of cell junction assembly), GO:0007399 (nervous system development), GO:0050807 (regulation of synapse organization), GO:0051965 (positive regulation of synapse assembly), GO:1901888 (regulation of cell junction assembly), GO:0043954 (cellular component maintenance), GO:0050804 (modulation of chemical synaptic transmission), GO:0099537 (trans-synaptic signaling), GO:0051960 (regulation of nervous system development), GO:0034330 (cell junction organization), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0051963 (regulation of synapse assembly), GO:0098916 (anterograde trans-synaptic signaling), GO:0050808 (synapse organization), GO:0099174 (regulation of presynapse organization), GO:0034331 (cell junction maintenance), GO:0034329 (cell junction assembly), GO:0007268 (chemical synaptic transmission), GO:0099558 (maintenance of synapse structure), GO:1905606 (regulation of presynapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0045202 (synapse), GO:0098978 (glutamatergic synapse)