Protein: 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha (OFOR1) (EC 1.2.7.11) (Q96Y66)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Function: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence: MRLSWVIGGAQGTGIDTAANIFGNAVASAGYYIYGNREYYSNIKGRHSYFSLTISDKRVRSNTQKIDILVSFDAETVFQHFYDVKDILIYNKAVETTKIDAVQSMEPELAERIKDFLTKQGYETTVKGALEYASKNNVTLIPVNYDEIAKKVADEMKVPLSVTERVKNIVGITISYKLLGLDVNYLIEAINSTFKQDLYRKMNELAVKDSYDIVESRYNLKPSSKERRRFWLDGNTAVAIGKIYGGVRFQSYYPITPASDESVYIEAHQDVLMEDPITGDKKKGTIVVVQAEDELAAINMAIGAALTGVRAATATSGPGFSLMVEGLGWAGMNEVPVVITYYIRGGPSTGLPTRTAQSDLIFPIFAGHGEFPKIVLASGDHAEAFKDAIWALNLAEKYQTPVIHLVEKTLANSYSTIPYEELELDKLKAERGKIVESGDISYKRFKFTEDGISPRAFLGKATMYYTGDEHNEEGHISEDVVNRTMMYEKRMKKLEVADKEIPEESRVKIYGDLNSRNLIITWGSPTGVLRDILEESNFDFTLLQIRMFSPFPKNLVSKLMEGRDKIITVEGNYLAQTSLLVKMYTGKDVTNSILKWNGRPFLRDELEEALIKVIKDGEKRVVLNGGI
InterPro domains: - IPR053400: 2-oxoacid:ferredoxin oxidoreductase alpha (family) [1-626]
- IPR009014: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II (homologous_superfamily) [503-616]
- IPR029061: Thiamin diphosphate-binding fold (homologous_superfamily) [228-496]
- IPR002869: Pyruvate-flavodoxin oxidoreductase, central domain (homologous_superfamily) [2-249]
- IPR050722: Pyruvate:ferredoxin/flavodoxin oxidoreductase (family) [224-619]
- IPR022367: 2-oxoacid:acceptor oxidoreductase, alpha subunit (family) [97-609]
- IPR019752: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain (domain) [12-207]
- IPR002880: Pyruvate flavodoxin/ferredoxin oxidoreductase, pyrimidine binding domain (domain) [234-488]
Interaction partners: - 2-oxoacid:ferredoxin oxidoreductase 2, subunit beta
- 2-oxoacid:ferredoxin oxidoreductase 1, subunit beta
- 2-oxoacid oxidoreductase
- 2-oxoacid oxidoreductase
- ADP-forming acetyl-CoA synthetase
- Succinyl-CoA synthetase beta subunit
- Succinate--CoA ligase subunit alpha
- Succinate-semialdehyde dehydrogenase
- Pyruvate kinase
- isocitrate dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006558 (L-phenylalanine metabolic process), GO:1902221 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)