Protein: Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) (S4X0Q8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Orphan receptor that acts as a critical modulator of planar cell polarity during gastrulation. Controls the localization of dishevelled.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23821037}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSVLCVLLLAFVLPLRGSSSAGSTECKTYDERSRSAGKSSPSGATLDRKVVCSNMEFRQVPSPDTFPNRTVSLILSNNKIQELLNGSFVGLSSLERLDIKNNIITHIEPGAFYGLFSLKRLDLSKNLIGCLHVDVFKGLTNLVKLNLSENKFSSLSQGIFDSLGSLKILEFDSPYLLCDCNLQWLVVWIKEKAIGVKETRCSFPRSLQGQLITTLRAETLTCDAPLELPSFQMTPSQHQIVFQGDSLPFQCMASFVDEDMQVLWYQDGKMVEPDATQGIYIEKSMVQNCSLIASALTISNIQPGFTGNWECRVRTSRGNNTRTVHIVVLESSAKYCLPDRVSNNKGEYRWPRTLAGITAYLPCKRQVTGAGIYSGSSAEDRRAWRRCDRGGQWAEDDYSRCEYMKDVTRVLYIINQMPLNLTNVVQTAQQLLAYTAEAPNFSDKVDVIFVAEMIEKIGKFAEKYKELGDVMVDISSNLLLADERVLWMAQREARACSRMVESLQRIALLRVSNGALAYSTNSPNIALEAHAIKASSFNGMTCTLFQKLSPERTVMAHHGEISPERQLSFKCNVTSNLSALALKNTIVEASLQLPPTLFSSLGSSGQAEEAVYKLHLLAFRNGKLFPPTGNSSILSDGSKRRSVVTPVMITKIEGFPLRDLLSPVNVTLRRFLQGSDAVPAFWNFSLQGGQGGWQSDGCRILHQDDNFTTVSCHSLNSYAVLMDLNRTGYNVFIFRPLHPVIYSTALVLVLCLLSVIVSYIYHHKSVRISKKCWHMLVNLCLHILLTCAVFVGGINQTYNASVCQAMGIVLHYSTLATALWSGVTARNIYKQVTRKAKRYEELDEPPPPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSQVNAPYCWMAWEPSLGAFYGPAAFIVFVDCMYFLSILIQLRRHPERRFELKEQSEEQQHLSVTEATEITPVHLESSPTAQPVPMSALENEHTFVSQLMGVAGSLTLYAALWVFGALAISQEHPADLVFACLFGALALGLGAFLVAHHCVNRQDMRRHWSQACCLIRRNYAVQVDSLLLPIAGSSGSVMTSRGNGEATKCPASSAESSCTNKSAPSLRNSTQGCKLTNLQVEAAQCKVVAPSTANGTAVLDNSLTEHSVDNEIKMHVAPIEIQYRPSSVNNNNLPGNANITGHPGRHHKNRSRAHRASRLTVLREYSYDVPTSVEGSVQSVPNKRHHHESLHARNSRRAAYLAYRERQQSQLQQDSSDAASTSVPRRSRHFSKGTRIGNGFGHGISNGGLLDGSEADVTNQTKECPKQTLTVELEVQPKSYGLNLACQNGSAKDSERLNVESSGNVKTGLWKHETTV
InterPro domains: - IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [310-405]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [24-225]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [228-330]
- IPR000832: GPCR, family 2, secretin-like (family) [740-1015]
- IPR046338: GAIN domain superfamily (homologous_superfamily) [556-730]
- IPR013098: Immunoglobulin I-set (domain) [229-328]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [227-335]
- IPR007110: Immunoglobulin-like domain (domain) [229-327]
- IPR000203: GPS motif (conserved_site) [675-727]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [71-162]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [176-223]
- IPR003599: Immunoglobulin domain subtype (domain) [236-329]
- IPR057244: GAIN, subdomain B (domain) [563-728]
- IPR001611: Leucine-rich repeat (repeat) [72-128]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [296-414]
- IPR017981: GPCR, family 2-like, 7TM (domain) [738-1031]
- IPR051963: Adhesion G protein-coupled receptor A (family) [48-1346]
Interaction partners: - Adhesion G protein-coupled receptor G7, tandem duplicate 1.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0035295 (tube development), GO:0001525 (angiogenesis), GO:0009967 (positive regulation of signal transduction), GO:0009888 (tissue development), GO:0198738 (cell-cell signaling by wnt), GO:0001568 (blood vessel development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0009966 (regulation of signal transduction), GO:0007166 (cell surface receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0035239 (tube morphogenesis), GO:0061548 (ganglion development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0016055 (Wnt signaling pathway), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0001570 (vasculogenesis), GO:0030111 (regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0002040 (sprouting angiogenesis), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0090263 (positive regulation of canonical Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:1990909 (Wnt signalosome), GO:0005886 (plasma membrane)