wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cell growth regulator with RING finger domain protein 1 (Cell growth regulatory gene 19 protein) (P97587)
Organism: Rattus norvegicus (Rat)
Function: Able to inhibit growth in several cell lines.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q99675}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q99675}.
Sequence: MAAVFLVTLYEYSPLFYIAVVFTCFIATTGLVLGWLGWDVPVILRNSEETQFSTRAFKKQMRQVKNPFGLEITNSSAASLATGVTLTTDCLEDSRLTCYWGCSVQKLYEALQKHVYCFRISTPQALEEALYSDYLHREQYFIKKHSKEEIYCQLPSSTGVEDFGPVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDKTYKLPCRILYQYLILAQGQFYDLKQLFMSANNSATPSRDQSPADGSVEHSLLEKAGLAGAEVDPVEESSKDCVVCQNGGVNWVLLPCRHACLCDSCVCYFKQCPMCRQFVQESFALCGQKEADKDILETS
InterPro domains: - IPR042496: Cell growth regulator with RING finger domain protein 1 (family) [1-329]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [260-318]
- IPR001841: Zinc finger, RING-type (domain) [274-309]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0010941 (regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Prothymosin alpha (B8ZZA1)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MNPCVLGTVPACRLTWPTDAGPDDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNANEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD
InterPro domains: - IPR004931: Prothymosin/parathymosin (family) [11-131]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0140297 (DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0010467 (gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Telomeric repeat binding factor 2 (H3BR06)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSSLPALLVRPLGKEHTVSRLLRVMQCLSRIEEGENLDCSFDMEAELTPLESAINVLEMIKTEFTLTEAVVESSRKLVKEAAVIICIKNKEFEKASKILKKHMSKDPTTQKLRNDLLNIIREKNLAHPVIQNFSYETFQQKMLRFLESHLDDAEPYLLTMAKKALKSESAASSTGKEDKQPAPGPVEKPPREPARQLRNPPTTIGMMTLKAAFKTLSGAQDSEAAFAKLDQKDLVLPTQALPASPALKNKRPRKDENESSAPADGEGGSELQPKNKRMTISRL
InterPro domains: - IPR030657: Telomeric repeat-binding factor 2 (family) [4-174]
- IPR013867: Telomere repeat-binding factor, dimerisation domain (domain) [3-170]
- IPR036507: Telomere repeat-binding factor, dimerisation domain superfamily (homologous_superfamily) [1-165]
- IPR031902: Telomeric repeat-binding factor 2, Rap1-binding domain (domain) [196-237]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0006807 (nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0036211 (protein modification process), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Breast carcinoma-amplified sequence 4 (Q8TDM0)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MQRTGGGAPRPGRNHGLPGSLRQPDPVALLMLLVDADQPEPMRSGARELALFLTPEPGAEAKEVEETIEGMLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGIYAKVDRLEAFVKMVGHHVAFLEADVLQAERDHGAFPQALRRWLGSAGLPSFRNVECSGTIPARCNLRLPGSSDSPASASQVAGITEVTCTGARDVRAAHTV
InterPro domains: - IPR024857: Cappuccino (family) [4-171]
Interaction partners: - BCAS3 microtubule associated cell migration factor
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosome-related organelles complex 1 subunit 1
- Biogenesis of lysosome-related organelles complex 1 subunit 2
- SNARE-associated protein Snapin
- Dysbindin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (F1NLP2)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Sequence: MRLLRALLRCASPGSIPQQVDFYSRFSPSPLSMKQFLDFGSENACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYVQSLQEILDFKDKSSEDSGAIHSFTDTVIKIRNRHNDVIPTMAQGVIEYKESFGIDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKINPAHPKHIGSIDPSCNVVGVIRDGYESAKSLCDLYYMSSPELVLEELNIKSPGQPMQVVYVPSHLYHMVFELFKNAMRATMEHNADRCIYPPIHVHVTLGNEDLTVKMSDRGGGVPMRKIDRLFNYMYSTAPRPRVETSRATPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYKANHEADDWCVPSSEPKDMTTFRST
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [187-373]
- IPR018955: Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal (domain) [30-192]
- IPR039028: PDK/BCKDK protein kinase (family) [12-374]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [240-365]
- IPR005467: Histidine kinase domain (domain) [226-365]
- IPR036784: Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily (homologous_superfamily) [10-186]
Interaction partners: - Acetyltransferase component of pyruvate dehydrogenase complex
- Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
- L-lactate dehydrogenase A chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004712 (protein serine/threonine/tyrosine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0018193 (peptidyl-amino acid modification), GO:0016310 (phosphorylation), GO:0018105 (peptidyl-serine phosphorylation), GO:0018209 (peptidyl-serine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen)
Protein: Sugar transport protein 2 (Hexose transporter 2) (Q9LNV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates an active uptake of hexoses, probably by sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose, xylose, mannose, fructose and galactose.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MAVGSMNVEEGTKAFPAKLTGQVFLCCVIAAVGGLMFGYDIGISGGVTSMDTFLLDFFPHVYEKKHRVHENNYCKFDDQLLQLFTSSLYLAGIFASFISSYVSRAFGRKPTIMLASIFFLVGAILNLSAQELGMLIGGRILLGFGIGFGNQTVPLFISEIAPARYRGGLNVMFQFLITIGILAASYVNYLTSTLKNGWRYSLGGAAVPALILLIGSFFIHETPASLIERGKDEKGKQVLRKIRGIEDIELEFNEIKYATEVATKVKSPFKELFTKSENRPPLVCGTLLQFFQQFTGINVVMFYAPVLFQTMGSGDNASLISTVVTNGVNAIATVISLLVVDFAGRRCLLMEGALQMTATQMTIGGILLAHLKLVGPITGHAVPLIVLILICVYVSGFAWSWGPLGWLVPSEIYPLEVRNAGYFCAVAMNMVCTFIIGQFFLSALCRFRSLLFFFFGIMNIIMGLFVVFFLPETKGVPIEEMAEKRWKTHPRWKKYFKD
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [16-485]
- IPR020846: Major facilitator superfamily domain (domain) [26-474]
- IPR005829: Sugar transporter, conserved site (conserved_site) [141-353]
- IPR044778: Sugar transport protein STP/MST-like, plant (family) [29-472]
- IPR003663: Sugar/inositol transporter (family) [13-481]
- IPR045262: Sugar transport protein STP/Polyol transporter PLT, plant (family) [14-496]
- IPR005828: Major facilitator, sugar transporter-like (family) [26-483]
Interaction partners: - At1g27000/T7N9_6)
- F3F20.10 protein
- MOB kinase activator-like 1A
- GDP-mannose transporter GONST1
- GDP-mannose transporter GONST2
- Ras-related protein RABA1i
- AT1G67850 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0051119 (sugar transmembrane transporter activity), GO:0015145 (monosaccharide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034219 (carbohydrate transmembrane transport), GO:0006810 (transport), GO:0015749 (monosaccharide transmembrane transport), GO:0071702 (organic substance transport), GO:0008643 (carbohydrate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: BAG family molecular chaperone regulator 1 (J3QTA2)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: LAQRGGARRPRGDRERLGSRLRALRPGREPRQSEPPAQRGPPPSGRPPARSTASGHDRPTRGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATWSEEATQSEEATQGEEMNRSQEVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRVMLIGKKNSPQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE
InterPro domains: - IPR003103: BAG domain (domain) [246-326]
- IPR000626: Ubiquitin-like domain (domain) [144-224]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [141-227]
- IPR036533: BAG domain superfamily (homologous_superfamily) [216-345]
- IPR039773: Molecular chaperone regulator BAG (family) [88-326]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0060590 (ATPase regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0000166 (nucleotide binding), GO:0019899 (enzyme binding), GO:1901265 (nucleoside phosphate binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0017076 (purine nucleotide binding), GO:0031625 (ubiquitin protein ligase binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0006457 (protein folding), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0061077 (chaperone-mediated protein folding), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0006458 ('de novo' protein folding), GO:0051084 ('de novo' post-translational protein folding), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0051085 (chaperone cofactor-dependent protein refolding), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) (Q62986)
Organism: Rattus norvegicus (Rat)
Function: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92731}.
Sequence: MEIKNSPSSLSSPASYNCSQSILPLEHGPIYIPSSYVDNRHEYSAMTFYSPAVMNYSVPGSTSNLDGGPVRLSTSPNVLWPTSGHLSPLATHCQSSLLYAEPQKSPWCEARSLEHTLPVNRETLKRKLSGSSCASPVTSPNAKRDAHFCPVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRIVRRQRSSSEQVHCLSKAKRNGGHAPRVKELLLSTLSPEQLVLTLLEAEPPNVLVSRPSMPFTEASMMMSLTKLADKELVHMIGWAKKIPGFVELSLLDQVRLLESCWMEVLMVGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLASANQEAESSRKLTHLLNAVTDALVWVIAKSGISSQQQSVRLANLLMLLSHVRHISNKGMEHLLSMKCKNVVPVYDLLLEMLNAHTLRGYKSSISGSECSSTEDSKNKESSQNLQSQ
InterPro domains: - IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [198-509]
- IPR024178: Estrogen receptor/oestrogen-related receptor (family) [13-530]
- IPR021064: Estrogen receptor beta-like, N-terminal (domain) [12-125]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [264-498]
- IPR050200: Nuclear hormone receptor family NR3 subfamily (family) [46-497]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [146-221]
- IPR028355: Estrogen receptor beta/gamma (family) [2-530]
- IPR001723: Nuclear hormone receptor (family) [210-474]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [140-248]
Interaction partners: - Nuclear receptor coactivator
- Estrogen receptor
- Proto-oncogene tyrosine-protein kinase Src
- Nuclear receptor coactivator 3
- Nuclear receptor coactivator 2
- Transcription factor Sp1
- Transcription factor Jun
- Protein c-Fos
- Mediator of RNA polymerase II transcription subunit 1
- Mitogen-activated protein kinase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043627 (response to estrogen)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Solute carrier family 30 member 10 (Zinc transporter 10) (A0A0R4IEQ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MGRYSGKTCRLILMLVITVIFFVAEIVAGYMGNSVALVSDSFNMLSDILSLCVGLTAARVSRRAGSGRFSFGLGRAEVVGALANAVFLIALCFSISMESLKRLAMPQAIDDAPLVLIVGSLGLAVNLVGLVIFQDCGRLCGRRGKEKKREEHREDREQELEQVETGLQEEKTEKDGAPLNIRGVLLHVLNDALGSVVVVVASALFYVWPLEPDQPCNWQCYVDPSLTLVMVIIILSSAAPLLKETTTILLQMSPEDLPVSAILESVCRLPGVSSVHEAHVWELAKGRNVASLHVKLQAPAGALWAQVSLQQQITQIFHRAGVHSLTLQLELADSDADSSCSAPCLSSSCQKLSCCPAGPVCVCAPPRDSSTEKHTPQACTHSSKL
InterPro domains: - IPR002524: Cation efflux protein (family) [10-331]
- IPR027469: Cation efflux transmembrane domain superfamily (homologous_superfamily) [5-251]
Interaction partners: - Metal cation symporter ZIP14
- Solute carrier family 39 member 8.
- Zinc transporter ZIP1
- Zinc-regulated GTPase metalloprotein activator 1
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter 6
- Solute carrier family 39
- Glucose-6-phosphate exchanger SLC37A1
- Zinc transporter ZIP13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0055071 (manganese ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006828 (manganese ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)