Protein: Calcium channel YVC1 (Q5A2J7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Vacuolar calcium channel involved in the release of calcium ions from the vacuole in response to hyperosmotic or alkaline stress. Required for activation of CAP1-related transcription of oxidative stress response (OSR) genes, but also for maintaining the stability of both the mitochondria and the vacuole in a potassium- and calcium- dependent manner. Contributes to pathogenicity. Plays a key role in hyphal polarized growth and re-orientation to host-signals through its contribution to the localization of the Spitzenkoerper to the hyphal tips
Subcellular location: Vacuole membrane; Multi-pass membrane protein
Sequence: MSELDLEENNPLLPPSQINDENYEGSIFGEDARFCPNSRQVFRICSNLKLLIDKIIPICFKEDEITSSNSAILSDPVIDLVYQAAGGKGDGKEGTSSYKYRGSLVFCLLKVCDWYWQQAEFELSDNELYSLRALTAQTIAAIIIEREKRDKYLFLNMLCHRYTICVNGVDATPVSALEMAVDMHSTIVIGSSGYQRCIKWLWRGWIIQSSTDPHSYVLYKGAASQSFRTHFDPARIKTPLYQNILEIFLSIIYLIIFTIVVNTHSTLTGDIDFFETVLYLFTVGYILDEFIKFYHVGWNYLGFWNAFNDTMYCILTVAVCFRIASVNSHGATRIKYDEISFRVLACASPLMWSRLLLFLDAYKFVGAMIVVLKTMMKESILFFFLLFVVIVGFLQGFIGLDSSDGKNEATQRILISLVKAVIGGSSFEDMGNLVPPYASVLYYFYQFMLTVILMNILIALYSTAYAAIVENATDEYFALVAHKTLRYIRAPDQNLYVPPFNLIELLITPIGWFVSTSTWKNINYYVMLVIYSPLLAYITSDELSNARRIQYNRFKGVPDDANEIDTEWDLTDGYDEDSPGDGDDCWDRIRERNSEITEELRIQREGERQDPEFMINTHQFSEKIDKIVKPVGQASKVGVNWQIYEVIEKIDKLTNLLEVVVAENKELKKRLENKA
InterPro domains: - IPR052971: Transient receptor potential calcium channel (family) [103-560]
- IPR056336: Calcium channel YVC1-like, C-terminal transmembrane domain (domain) [261-540]
- IPR056337: YVC1, N-terminal linker helical domain (domain) [41-231]
Interaction partners: - Ion-transporting P-type ATPase
- Calcium-channel protein CCH1
- Calcium-transporting ATPase
- ATP-dependent RNA helicase DHH1
- Uncharacterized protein
- Mid1p
- Vacuolar calcium ion transporter
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005217 (intracellular ligand-gated monoatomic ion channel activity), GO:0043855 (cyclic nucleotide-gated monoatomic ion channel activity), GO:0005221 (intracellular cyclic nucleotide activated monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole), GO:0098852 (lytic vacuole membrane), GO:0000329 (fungal-type vacuole membrane)