Protein: Nudix hydrolase 23, chloroplastic (AtNUDT23) (EC 3.6.1.-) (ADP-ribose pyrophosphatase) (EC 3.6.1.13) (FAD diphosphatase) (EC 3.6.1.18) (P93740)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use FAD and ADP-ribose as substrates.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:18815383}.
Sequence: MLKAVQILGWSSGLTISQRLTKTRKSSTVSFISSSLNLSSVTSSSPRRIFSFKPTRMSSSLPGSDPVANSPTFVSVQSAGDVRKIKFCQWCGGPTKHEIPDGEEKLRAICTHCGKIAYQNPKMVVGCLIEHEGKVLLCKRNIQPSHGLWTLPAGYLEVGESAAQGAMRETWEEAGATVEVISPFAQLDIPLIGQTYVIFLAKLKNLHFAPGPESLECRLFALDEIPFDSLAFSSIYVTLNLYLEDLKKGKLKFHYGTINKRPGSSPSDIRAFSLDYHLQP
InterPro domains: - IPR020084: NUDIX hydrolase, conserved site (conserved_site) [154-175]
- IPR029401: Nudix hydrolase, N-terminal (domain) [86-119]
- IPR000086: NUDIX hydrolase domain (domain) [120-243]
- IPR020476: NUDIX hydrolase (domain) [149-178]
- IPR015797: NUDIX hydrolase-like domain superfamily (homologous_superfamily) [86-247]
Interaction partners: - Bifunctional riboflavin kinase/FMN phosphatase
- FAD synthetase 2, chloroplastic
- FAD synthetase 1, chloroplastic
- Purple acid phosphatase 4
- Purple acid phosphatase 8
- Purple acid phosphatase 7
- Purple acid phosphatase 3
- Purple acid phosphatase 17
- Flavin mononucleotide hydrolase 1, chloroplatic
- Chaperone DnaJ-domain superfamily protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901575 (organic substance catabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019439 (aromatic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:1901361 (organic cyclic compound catabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046434 (organophosphate catabolic process), GO:0009261 (ribonucleotide catabolic process), GO:0072523 (purine-containing compound catabolic process), GO:0009117 (nucleotide metabolic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:1901292 (nucleoside phosphate catabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0009154 (purine ribonucleotide catabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0034033 (purine nucleoside bisphosphate biosynthetic process), GO:0009166 (nucleotide catabolic process), GO:0006195 (purine nucleotide catabolic process), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0046031 (ADP metabolic process), GO:0046033 (AMP metabolic process), GO:0009127 (purine nucleoside monophosphate biosynthetic process), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome), GO:0110156 (methylguanosine-cap decapping), GO:0009152 (purine ribonucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)