Protein: HTH-type transcriptional regulator CdhR (Carnitine catabolism transcriptional activator) (Q9HTH5)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Induces the transcription of the PA5384-PA5388 operon in response to carnitine. This operon is involved in the degradation of L-carnitine, and allows P.aeruginosa to grow on L-carnitine as the sole source of carbon and nitrogen.
Sequence: MSQDFWFLLLPGFSVMGFVSAVEPLRVANRFHADLYRWHVLSADGGPVLASNGMSVNSDGALEPLKKGDLLFVVAGFEPLRAVTPALVQWLRKLDRNGVTLGGIDTGSVVLAEAGLLDGRRATLHWEAIDAFQESYPQLSVTQELFEIDGPRITSAGGTASIDLMLDLIAQAHGPQLAVQVSEQFVLGRIRPRQDHQRLQVATRYGVSNRKLVQVIGEMERHTEPPLTTLELAERIQVTRRQLERLFRVHLDDTPSNFYLGLRLDKARQLLRQTDLSVLQVSLACGFESPSYFSRSYRARFAASPSQDRAVLPLKAPAATPPGAPAGHRTPRAERG
InterPro domains: - IPR029062: Class I glutamine amidotransferase-like (homologous_superfamily) [2-199]
- IPR018062: HTH domain AraC-type, conserved site (conserved_site) [263-305]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [262-310]
- IPR018060: AraC-like, DNA binding HTH domain (domain) [213-311]
- IPR052158: Isonitrile Hydratase and Quaternary Amine Regulator (family) [4-272]
- IPR002818: DJ-1/PfpI (domain) [19-170]
Interaction partners: - ABC-type glycine betaine transport system substrate-binding domain-containing protein
- MmsAB operon regulatory protein
- 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase
- Betainyl-CoA thioesterase
- L-carnitine dehydrogenase
- Transcriptional regulator XylS
- ChoE
- 3-oxoadipate CoA-transferase
- Probable lipolytic enzyme
- Probable transcriptional regulator
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0009894 (regulation of catabolic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0009896 (positive regulation of catabolic process), GO:0033240 (positive regulation of amine metabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051336 (regulation of hydrolase activity), GO:0006577 (amino-acid betaine metabolic process), GO:0006521 (regulation of cellular amino acid metabolic process), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0045764 (positive regulation of amino acid metabolic process), GO:0033238 (regulation of amine metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042219 (cellular modified amino acid catabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0010921 (regulation of phosphatase activity), GO:0031455 (glycine betaine metabolic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0006579 (amino-acid betaine catabolic process), GO:0060191 (regulation of lipase activity), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0051345 (positive regulation of hydrolase activity), GO:0045893 (positive regulation of DNA-templated transcription), GO:0010517 (regulation of phospholipase activity), GO:0035306 (positive regulation of dephosphorylation), GO:0035303 (regulation of dephosphorylation), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0010922 (positive regulation of phosphatase activity), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0060193 (positive regulation of lipase activity), GO:0010518 (positive regulation of phospholipase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)