Protein: Nuclear receptor coactivator (A0A8I6GLM3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
Sequence: MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDNKEIASILNEMIQSDNSANEGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPASLQPTPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYPQPYSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANVQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTEADGNQQVQQLQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE
InterPro domains: - IPR028819: Nuclear receptor coactivator 1, basic helix-loop-helix (domain) [27-87]
- IPR017426: Nuclear receptor coactivator (family) [1-1393]
- IPR037077: Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily (homologous_superfamily) [923-981]
- IPR014935: Nuclear receptor coactivator, receptor-binding domain (domain) [631-709]
- IPR014920: Nuclear receptor coactivator, Ncoa-type, interlocking (domain) [927-972]
- IPR013767: PAS fold (domain) [115-172]
- IPR009110: Nuclear receptor coactivator, interlocking (homologous_superfamily) [923-969]
- IPR000014: PAS domain (domain) [109-213]
- IPR010011: Nuclear receptor coactivator, DUF1518 (domain) [1152-1270]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [14-120]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [23-86]
- IPR035965: PAS domain superfamily (homologous_superfamily) [120-365]
- IPR056193: Nuclear receptor coactivator 1-3, bHLH domain (domain) [1-77]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0044877 (protein-containing complex binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0140297 (DNA-binding transcription factor binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0016922 (nuclear receptor binding), GO:0042974 (nuclear retinoic acid receptor binding), GO:0030331 (nuclear estrogen receptor binding), GO:0046965 (nuclear retinoid X receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0065008 (regulation of biological quality), GO:0019098 (reproductive behavior), GO:0048522 (positive regulation of cellular process), GO:0042698 (ovulation cycle), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0048609 (multicellular organismal reproductive process), GO:0007610 (behavior), GO:0021766 (hippocampus development), GO:0021987 (cerebral cortex development), GO:0021854 (hypothalamus development), GO:0007617 (mating behavior), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0021537 (telencephalon development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0045137 (development of primary sexual characteristics), GO:0044849 (estrous cycle), GO:0022037 (metencephalon development), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009891 (positive regulation of biosynthetic process), GO:0045924 (regulation of female receptivity), GO:0021549 (cerebellum development), GO:0050878 (regulation of body fluid levels), GO:0021536 (diencephalon development), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0030900 (forebrain development), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0021543 (pallium development), GO:0031323 (regulation of cellular metabolic process), GO:0007548 (sex differentiation), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0061458 (reproductive system development), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0032355 (response to estradiol), GO:0060179 (male mating behavior), GO:0071310 (cellular response to organic substance), GO:0048732 (gland development), GO:0048545 (response to steroid hormone), GO:0008406 (gonad development), GO:0060180 (female mating behavior), GO:0046546 (development of primary male sexual characteristics), GO:0046903 (secretion), GO:0010468 (regulation of gene expression), GO:0007420 (brain development), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0007399 (nervous system development), GO:0021761 (limbic system development), GO:0007589 (body fluid secretion), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0014070 (response to organic cyclic compound), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0032526 (response to retinoic acid), GO:0030879 (mammary gland development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0008584 (male gonad development), GO:0032570 (response to progesterone), GO:0007595 (lactation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)