Protein: Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49) (P11413)
Organism: Homo sapiens (Human)
Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:35122041, ECO:0000269|PubMed:743300}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:743300}.
Sequence: MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPIPYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [30-210]
- IPR019796: Glucose-6-phosphate dehydrogenase, active site (active_site) [200-206]
- IPR022674: Glucose-6-phosphate dehydrogenase, NAD-binding (domain) [35-210]
- IPR022675: Glucose-6-phosphate dehydrogenase, C-terminal (domain) [212-503]
- IPR001282: Glucose-6-phosphate dehydrogenase (family) [19-511]
Interaction partners: - Glucose-6-phosphate isomerase
- 6-phosphogluconate dehydrogenase, decarboxylating
- 6-phosphogluconolactonase
- Cellular tumor antigen p53
- GDH/6PGL endoplasmic bifunctional protein
- Glyceraldehyde-3-phosphate dehydrogenase
- Hexokinase-4
- L-lactate dehydrogenase A chain
- Hexokinase-2
- Glucose-6-phosphatase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004345 (glucose-6-phosphate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062014 (negative regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0006740 (NADPH regeneration), GO:0031326 (regulation of cellular biosynthetic process), GO:1902930 (regulation of alcohol biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0072521 (purine-containing compound metabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0051156 (glucose 6-phosphate metabolic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0019218 (regulation of steroid metabolic process), GO:0050810 (regulation of steroid biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0090030 (regulation of steroid hormone biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0006098 (pentose-phosphate shunt), GO:0009051 (pentose-phosphate shunt, oxidative branch), GO:0010566 (regulation of ketone biosynthetic process), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0006739 (NADP metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)