Protein: Bradykinin-potentiating and C-type natriuretic peptides (Brain BPP-CNP) (bBPP-CNP) (Evasin-CNP) [Cleaved into: Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a); Bradykinin-potentiating peptide 10c+QQWA (BPP-10c+QQWA); Bradykinin-potentiating peptide 10c (BPP-10c) (BPP-2) (Evasin-10c); Bradykinin-potentiating peptide 12b (BPP-12b) (Evasin-12b); Bradykinin-potentiating peptide AP; Bradykinin-potentiating peptide APL (BPP-APL); Bradykinin-potentiating peptide 11e (BPP-11e) (Evasin-11e); Bradykinin-potentiating peptide 5a (BPP-5a) (Bradykinin-potentiating peptide Va) (BPPVa) (Evasin-5a) (Proline-rich peptide 5a) (Bj-PRO-5a) (PRO-5a); Poly-His-poly-Gly peptide 1 (pHpG-1); C-type natriuretic peptide (Bj-CNP)] (Q9PW56)
Organism: Bothrops jararaca (Jararaca) (Bothrops jajaraca)
Function: Modestly inhibits ACE (with highest affinity for the N-site) and reveals strong bradykinin-potentiating activity. Induces nitric oxide (NO) production depended on muscarinic acetylcholine receptor M1 subtype (CHRM1) and bradykinin B2 receptor (BDKRB2) activation. Both these receptors contribute to the vasodilation induced by this peptide that may have an indirect action on BDKRB2 and a direct agonistic action on CHRM1.
Subcellular location: Secreted. Cytoplasm, cytosol. Note=BPP-10c is internalized in the cytosol of prey cells.
Sequence: MVLSRLAASGLLLLALLALSVDGKPVQQWAQGGWPRPGPEIPPLKVQQWAQGGWPRPGPEIPPLTVQQWAQNWPHPQIPPLTVQQWAQWGRPPGPPIPPLTVQQWAQARPPHPPIPPAPLQKWAPVQKWAPLLQPHESPASGTTALREELSLGPEAASGVPSAGAEVGRSGSKAPAAPHRLSKSKGAAATSAASRPMRDLRPDGKQARQNWGRMVHHDHHAAVGGGGGGGGGGARRLKGLAKKGAAKGCFGLKVDRIGTMSGLGC
InterPro domains: - IPR030480: Natriuretic peptide, conserved site (conserved_site) [249-265]
- IPR000663: Natriuretic peptide (family) [235-265]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity), GO:0005184 (neuropeptide hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0045746 (negative regulation of Notch signaling pathway), GO:0008593 (regulation of Notch signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)