Protein: Diaminopimelate decarboxylase 2, chloroplastic (DAP decarboxylase 2) (DAPDC 2) (EC 4.1.1.20) (Q94A94)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Sequence: MAAVTQFLSQPSSIRGTLNQYQLNQTSLSRIPFLSLKSTLKPLKRLSVKAAVSQNSTKTLTKESASSFDHCFKKSSDGFLYCEGTKVQDIMETVEKRPFYLYSKPQITRNLEAYKEALEGVRSVIGYAIKANNNLKILEHLRSLGCGAVLVSGNELRLALLAGFDPTKCIFNGNGKSLEDLVLAAQEGVFVNVDSEFDLNNIVEASRISGKQVNVLLRINPDVDPQVHPYVATGNKNSKFGIRNEKLQWFLDEVKAHPKELKLVGAHCHLGSTITKVDIFRDAAVLMIEYIDEIRRQGFEVSYLNIGGGLGIDYYHAGAVLPTPMDLINTVRELVLSRDLNLIIEPGRSLIANTCCFVNHVTGVKTNGTKNFIVIDGSMAELIRPSLYDAYQHIELVSPTPPEAEVTKFDVVGPVCESADFLGKDRELPTPPQGAGLVVHDAGAYCMSMASTYNLKMRPPEYWVEEDGSITKIRHAETFDDHLRFFEGL
InterPro domains: - IPR029066: PLP-binding barrel (homologous_superfamily) [97-353]
- IPR022657: Orn/DAP/Arg decarboxylase 2, conserved site (conserved_site) [298-311]
- IPR022644: Orn/DAP/Arg decarboxylase 2, N-terminal (domain) [106-352]
- IPR022643: Orn/DAP/Arg decarboxylase 2, C-terminal (domain) [353-443]
- IPR002986: Diaminopimelate decarboxylase, LysA (family) [74-487]
- IPR009006: Alanine racemase/group IV decarboxylase, C-terminal (homologous_superfamily) [86-484]
- IPR000183: Ornithine/DAP/Arg decarboxylase (family) [127-456]
- IPR022653: Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site (binding_site) [127-145]
Interaction partners: - Diaminopimelate epimerase, chloroplastic
- Alpha-aminoadipic semialdehyde synthase
- aspartate-semialdehyde dehydrogenase
- Diaminopimelate decarboxylase 1, chloroplastic
- LL-diaminopimelate aminotransferase, chloroplastic
- Aspartokinase 1, chloroplastic
- Aspartokinase 2, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 2, chloroplastic
- Aspartokinase 3, chloroplastic
- 4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0006591 (ornithine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)