Protein: V-type proton ATPase subunit a (Q57VD3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MSSEAASGLWRSEDMTLLRLTMQRETAHDSVLKLGQLAAFQFIDLNSDVSAFQRDFVQEVRRCDGMERKLRYLHDEIEKAGLTCVSTEAIGRESLFALEHKIDEYEGELRELNGQYQSLLEESNRTQEHLEVLSREFGSGIRQSPGLNLLTGVIPKDRIATLERLVYRITRGNSVLHTDEITTPFSEGEKERMVQKCVFGVYFATPRLWESLKRISEVNGASLYPYAESTERLQYMRDTLNSQLETMKHTLQQSLLRQRHLLTSISHNVCQWRQTVAVEKSVFSTMNMLKFSGSTAVAKGWAPVRSLDRIRASLQEAEYLSGAQVLTIVEEISTKEKRPTCFFTNKFTVCFQSIVDSYGMARYKEVNPGVLTIVTFPYLFGIMYGDIGHGVMLTLFAAFLLIKEKDWEGRKLNEIFAMIFDGRYLLLLMGLFAIYVGFLYNDFFGFSVDTFRSGYQWPPLNGNTQEGDMQPSSPSGVTPARSVIFGIDSAWAETENKLEFYNSVKMKCSVIIGVVQMVAGVILSLMNHIYFGDRIQIWFRFVPEIVFLLCTFGYMCVLIIIKWCTNWDQRTSEAPSLLETMTNFFLQPGTVNVPLYKGQEFVQVLLLLIAFAMVPILLCAIPMHEKKEHERKMRLQALARRNEDERHEGSEDDYDEDEKFDFSEVVIHQVIHTIEYVLGCVSNTASYLRLWALSLAHSQLSEVFWSFTFLMALDMDKGSGVFVFFGLCVWMCATVAVLLGMESLSAFLHALRLHWVEFNNKFYAADGYPFTPFNIAEVLKELD
InterPro domains: - IPR026028: ATPase, V0 complex, subunit 116kDa, eukaryotic (family) [5-783]
- IPR002490: V-type ATPase, V0 complex, 116kDa subunit family (family) [9-780]
Interaction partners: - V-type proton ATPase subunit F
- V-type ATPase, C subunit, putative
- 
- V-type proton ATPase subunit
- Uncharacterized protein
- ATP synthase, putative
- Vacuolar proton pump subunit B
- Vacuolar ATP synthase subunit D, putative
- H
- V-type proton ATPase subunit H
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0055085 (transmembrane transport), GO:0006885 (regulation of pH), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0030641 (regulation of cellular pH), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0051453 (regulation of intracellular pH), GO:0006811 (monoatomic ion transport), GO:0051452 (intracellular pH reduction), GO:0006812 (monoatomic cation transport), GO:1902600 (proton transmembrane transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0007035 (vacuolar acidification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0016469 (proton-transporting two-sector ATPase complex), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005794 (Golgi apparatus), GO:0033177 (proton-transporting two-sector ATPase complex, proton-transporting domain), GO:0005773 (vacuole), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0005770 (late endosome), GO:0033176 (proton-transporting V-type ATPase complex), GO:0005774 (vacuolar membrane), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0016471 (vacuolar proton-transporting V-type ATPase complex)