Protein: Kinesin-like protein KIF22 (Kinesin-like DNA-binding protein) (Kinesin-like protein 4) (Q14807)
Organism: Homo sapiens (Human)
Function: Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells.
Subcellular location: Nucleus {ECO:0000269|PubMed:8599929}. Cytoplasm, cytoskeleton {ECO:0000305}.
Sequence: MAAGGSTQQRRREMAAASAAAISGAGRCRLSKIGATRRPPPARVRVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIANWRNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDPASGDLVIREDCRGNILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHALGPVKLSQKELLGPPEAKRARGPEEEEIGSPEPMAAPASASQKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQGAPLLSTPKRERMVLMKTVEEKDLEIERLKTKQKELEAKMLAQKAEEKENHCPTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQAASPNAEIHILKNKGRKRKLESLDALEPEEKAEDCWELQISPELLAHGRQKILDLLNEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQVEDLERVEGITGKQMESFLKANILGLAAGQRCGAS
InterPro domains: - IPR003583: Helix-hairpin-helix DNA-binding motif, class 1 (domain) [602-651]
- IPR027640: Kinesin-like protein (family) [42-380]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [268-279]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [43-492]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [31-369]
- IPR001752: Kinesin motor domain (domain) [41-376]
- IPR010994: RuvA domain 2-like (homologous_superfamily) [570-660]
Interaction partners: - Kinesin-like protein KIF2C
- Kinesin-like protein KIF11
- Transforming acidic coiled-coil-containing protein 3
- Odorant-binding protein 2b
- Myc-associated zinc finger protein
- Kinesin-like protein KIFC1
- Baculoviral IAP repeat-containing protein 5
- Protein regulator of cytokinesis 1
- Rac GTPase-activating protein 1
- Serine/threonine-protein kinase PLK1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051302 (regulation of cell division), GO:0051726 (regulation of cell cycle), GO:0051781 (positive regulation of cell division), GO:0090068 (positive regulation of cell cycle process), GO:0042127 (regulation of cell population proliferation), GO:0010564 (regulation of cell cycle process), GO:0008284 (positive regulation of cell population proliferation), GO:0045787 (positive regulation of cell cycle), GO:0032465 (regulation of cytokinesis), GO:0032467 (positive regulation of cytokinesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)