Protein: Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) (Q9CS84)
Organism: Mus musculus (Mouse)
Function: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
Subcellular location: Presynaptic cell membrane {ECO:0000269|PubMed:21410790}; Single-pass type I membrane protein {ECO:0000269|PubMed:21410790}.
Sequence: MGTALVQRGGCCLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
InterPro domains: - IPR003585: Neurexin/syndecan/glycophorin C (domain) [1459-1477]
- IPR050372: Neurexin-related cell adhesion and synaptic protein (family) [280-720]
- IPR001791: Laminin G domain (domain) [30-1331]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [11-1310]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [698-709]
- IPR000742: EGF-like domain (domain) [216-1127]
Interaction partners: - Neuroligin-1
- Neuroligin-3
- Neuroligin-2
- Leucine-rich repeat transmembrane neuronal protein 2
- Cerebellin-1
- Dystroglycan 1
- Peripheral plasma membrane protein CASK
- Disks large homolog 4
- Neurexophilin-1
- Glutamate receptor ionotropic, delta-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0031503 (protein-containing complex localization), GO:0051240 (positive regulation of multicellular organismal process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0033036 (macromolecule localization), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0044085 (cellular component biogenesis), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0051649 (establishment of localization in cell), GO:0001505 (regulation of neurotransmitter levels), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0051668 (localization within membrane), GO:0097120 (receptor localization to synapse), GO:0099536 (synaptic signaling), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0099177 (regulation of trans-synaptic signaling), GO:0023061 (signal release), GO:0099645 (neurotransmitter receptor localization to postsynaptic specialization membrane), GO:0050804 (modulation of chemical synaptic transmission), GO:0046903 (secretion), GO:0022607 (cellular component assembly), GO:0006836 (neurotransmitter transport), GO:0007399 (nervous system development), GO:0031644 (regulation of nervous system process), GO:0099643 (signal release from synapse), GO:0099537 (trans-synaptic signaling), GO:0007269 (neurotransmitter secretion), GO:0008104 (protein localization), GO:0099173 (postsynapse organization), GO:0006996 (organelle organization), GO:0034330 (cell junction organization), GO:0072657 (protein localization to membrane), GO:0007416 (synapse assembly), GO:0070925 (organelle assembly), GO:0033365 (protein localization to organelle), GO:0099068 (postsynapse assembly), GO:1902414 (protein localization to cell junction), GO:1903539 (protein localization to postsynaptic membrane), GO:0099171 (presynaptic modulation of chemical synaptic transmission), GO:1990778 (protein localization to cell periphery), GO:0099084 (postsynaptic specialization organization), GO:0034329 (cell junction assembly), GO:0098916 (anterograde trans-synaptic signaling), GO:0050808 (synapse organization), GO:0007268 (chemical synaptic transmission), GO:1904861 (excitatory synapse assembly), GO:0035418 (protein localization to synapse), GO:0097106 (postsynaptic density organization), GO:0099633 (protein localization to postsynaptic specialization membrane), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)