Protein: Monopolin complex subunit CSM1 (Chromosome segregation in meiosis protein 1) (P25651)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Also plays a mitotic role in DNA replication.
Subcellular location: Nucleus, nucleolus. Chromosome, centromere. Note=Transiently released from the nucleolus and localizes to the centromere regions during late pachytene.
Sequence: MDPLTVYKNSVKQQIDSADLLVANLVNENFVLSEKLDTKATEIKQLQKQIDSLNAQVKELKTQTSQQAENSEVIKDLYEYLCNVRVHKSYEDDSGLWFDISQGTHSGGSSDDYSIMDYKLGFVKGQAQVTEVIYAPVLKQRSTEELYSLQSKLPEYLFETLSFPLSSLNQFYNKIAKSLNKKREKKDETE
InterPro domains: - IPR020981: Monopolin complex subunit Csm1/Pcs1, C-terminal (domain) [73-165]
- IPR041671: Csm1 N-terminal domain (domain) [1-70]
- IPR040349: Monopolin complex subunit Csm1/Pcs1 (family) [4-186]
- IPR038608: Csm1/Pcs1, C-terminal domain superfamily (homologous_superfamily) [83-190]
Interaction partners: - Monopolin complex subunit LRS4
- Monopolin complex subunit MAM1
- Protein DSE3
- Casein kinase I homolog HRR25
- Kinetochore-associated protein DSN1
- Topoisomerase 1-associated factor 2
- Ubiquitin-like-specific protease 2
- Inner nuclear membrane protein SRC1
- Nuclear rim protein 1
- Tyrosine-protein phosphatase CDC14
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:1903046 (meiotic cell cycle process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0051726 (regulation of cell cycle), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0007127 (meiosis I), GO:0090304 (nucleic acid metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0006259 (DNA metabolic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:1901988 (negative regulation of cell cycle phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:0033365 (protein localization to organelle), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0048285 (organelle fission), GO:0000723 (telomere maintenance), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0000077 (DNA damage checkpoint signaling), GO:0034502 (protein localization to chromosome), GO:0000725 (recombinational repair), GO:0000280 (nuclear division), GO:0032200 (telomere organization), GO:0006312 (mitotic recombination), GO:0035825 (homologous recombination), GO:0006302 (double-strand break repair), GO:0031573 (mitotic intra-S DNA damage checkpoint signaling), GO:0000724 (double-strand break repair via homologous recombination), GO:0140527 (reciprocal homologous recombination), GO:0045003 (double-strand break repair via synthesis-dependent strand annealing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0098687 (chromosomal region), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)