Protein: N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2) (P30337)
Organism: Rattus norvegicus (Rat)
Function: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Sequence: MPSKESWSGRKTNRATVHKSKQEGRQQDLLIAALGMKLGSQKSSVTIWQPLKLFAYSQLTSLVRRATLKENEQIPKYEKVHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHITKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIVDPDEQLETLHEALRSLPPAHCETLRYLMAHLKRVTLHEKENLMSAENLGIVFGPTLMRSPELDPMAALNDIRYQRLVVELLIKNEDILF
InterPro domains: - IPR046349: C1-like domain superfamily (homologous_superfamily) [72-133]
- IPR037860: Chimaerin, RhoGAP domain (domain) [141-334]
- IPR020454: Diacylglycerol/phorbol-ester binding (domain) [78-131]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [80-132]
- IPR051854: Rho-type GTPase-activating protein (family) [54-334]
- IPR000198: Rho GTPase-activating protein domain (domain) [143-334]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [134-334]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0060089 (molecular transducer activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0038023 (signaling receptor activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048609 (multicellular organismal reproductive process), GO:0032989 (cellular component morphogenesis), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0001675 (acrosome assembly), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0016043 (cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0007283 (spermatogenesis), GO:0010256 (endomembrane system organization), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0022607 (cellular component assembly), GO:0033363 (secretory granule organization), GO:0070925 (organelle assembly), GO:0016050 (vesicle organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0045211 (postsynaptic membrane), GO:0098797 (plasma membrane protein complex), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane)