Protein: Protein expanded (Q07436)
Organism: Drosophila melanogaster (Fruit fly)
Function: Activates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Ex acts synergistically along with Mer and Kibra to regulate the Hippo signaling pathway. Involved in the control of cell proliferation in imaginal disks. May bind to certain proteins of signal transduction pathways by interaction with their SH3 domains. Required for apical localization of Schip1.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:20159598}. Note=Apical surface of disk cells.
Sequence: MRAFCTVSAPLEVCASSAEQLSPGSRFLALRLLGQQQPKTLYFLVDAKSRVREVYTQTCLHFATQGMLDTELFGLAVLIDGEYMFADPESKLSKYGPKSWRSSHTHGLDANGRPLLELHFRVQFYIESPFMLKDETSRHNYYLQLRHNILQRDLPREQAEQALVFLAGLALQADLGDAPPGTSNSKDDSGEETSASPSNGGRGLSATTTLPKISKRANERMLRLSTYVASTSKRETIPLPPSLPPNGADYYRIEDYLPSGLHTPWARSAMRACHREHLGMATAEAELLYIQQACSLHETINAHTYRMRLAKSEQGSGSAWFVVYAKGIKILGGESTNSSSNPETTTFLWPNITKLSFERKKFEIRSGESRITLYAASDEKNKLLLTLCKDTHQWSMKLAARLKEVSKREEEEAAESQRLHASYACSRSLLLPYKSKNEQRISVISSTSSNTTSGIVSDRVHSEDELEIMINTPPAPLAAPSTESLALAHLLDRPSVSRQTSSVGQMSLKDLEEQLAALSVRPQDASSNGATIVTNSSVQRNSMGTTANDSSTATDSPSSQHNIGSQCSSTCSTVVVTSPVNGAGASSSGAPIPVHSTSSSLELGFSHTAQNSALSETSPDDFLSTSAREETESVSGASGVYTLAHGAPPTETSGVYTMHSSELTGQSSEIAESEKSSHYGMFQPQKLEETHVQHSDSVDGKKKEDFRPRSDSNVSTGSSFRGDGSDPTDNKHSLLSAEELTNLIVGRGTYPSRKTVSSSLHSDCDYVTLPLGDQGEEEVDQPPAPPPPYSARHEKTGLCGPPIAKPIPKPIAVVAPKPDSPPCSPPVPPAPIPAPPPAIRRRDPPPYSISSKPRPTSLISVSSSAHPAPSAAGSMSSLKSEEVTARFITTRPQISILKAHTSLIPDGAKPSYAAPHHCSSVASSNGSVCSHQLSQQSLHNSNYAGGSQASLHHHHVPSHHRHSGSAAIGIVPYGLHKSTASLHHQQSCVLLPVIKPRQFLAPPPPSLPRQPPPPPPPNHPHLASHLYEREMARKQLELYQQQLYSDVDYVIYPIQDPAVSQQEYLDAKQGSLLAAMAQAAPPPPHHPYLAMQVSPAIYRSTPYLPLTLSTHSRYASTQNLSDTYVQLPGPGYSPLYSPSMASLCSSYEPPPPPPLHPAALAAAAAAGAGSSSSSMFARSRSDDNILNSLDLLPKGKRLPPPPPPPYVNRRLKKPPMPAPSEKPPPIPSKPIPSRMSPIPPRKPPTLNPHHANSPLTKTSSGAQWAGERPRPDLGLGLGLNRGNNSILAQLQASMVAQSHAQAQAQALDIALLREKSKHLDLPLISALCNDRSLLKQTKVVINPKTGQEMPTSSAQPSGATTNGVANSSAGAGTLSKARKGSTVSHRHPQDKLPPLPVQQLAEANNYVIDPAVMMKQQQQQQQHNKTS
InterPro domains: - IPR041781: FERM domain-containing protein 6, FERM domain C-lobe (domain) [298-405]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [127-296]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [40-127]
- IPR000299: FERM domain (domain) [26-399]
- IPR019749: Band 4.1 domain (domain) [22-304]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [124-297]
- IPR018980: FERM, C-terminal PH-like domain (domain) [314-403]
- IPR047145: FERM domain-containing protein 6-like (family) [2-1426]
- IPR019748: FERM central domain (domain) [131-305]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [301-401]
Interaction partners: - Transcriptional coactivator yorkie
- Latrophilin Cirl
- Protein kibra
- Serine/threonine-protein kinase hippo
- Moesin/ezrin/radixin homolog 2
- Cadherin-related tumor suppressor
- Protein crumbs
- Serine/threonine-protein kinase Warts
- Supernumerary limbs, isoform B
- G protein beta subunit 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007163 (establishment or maintenance of cell polarity), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048523 (negative regulation of cellular process), GO:0009791 (post-embryonic development), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0030010 (establishment of cell polarity), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007164 (establishment of tissue polarity), GO:0016043 (cellular component organization), GO:0035107 (appendage morphogenesis), GO:0042335 (cuticle development), GO:0009886 (post-embryonic animal morphogenesis), GO:0022008 (neurogenesis), GO:0001737 (establishment of imaginal disc-derived wing hair orientation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048737 (imaginal disc-derived appendage development), GO:0008544 (epidermis development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0001736 (establishment of planar polarity), GO:0030855 (epithelial cell differentiation), GO:0035220 (wing disc development), GO:0035315 (hair cell differentiation), GO:0048699 (generation of neurons), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0001738 (morphogenesis of a polarized epithelium), GO:0009913 (epidermal cell differentiation), GO:0007472 (wing disc morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0035317 (imaginal disc-derived wing hair organization), GO:0035316 (non-sensory hair organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)