Protein: APC regulator of WNT-signaling pathway (A0A8M2B1L0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLNKLETEASNMKEVLKQLQGSIDEDSKDSQGQIEFLERIKEMSLDPSGFSGVKLRSKASLQGSADSSPSPSPVSSCPRRGASSGGRDSAGYLEELEKERSLLVAELEKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEDQLGTCQDMEKRAQGRVARIQQIEKDMLRIRTRLQAQSAESEVKHEPLSQTEGSHAAGDAGAAAAASVCSQGSASRVDHDSASEMSSAGSYSVPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQESHERGVDQDKNPMPSPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIGELLQVDCEIYGLTNDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRAMVAQLKSESEDLQQVIASVLRNLSWRADVNSKKILREVGSVRALMECALEVQKESTLKSVLSALWNLSAHCTENKADICTVPGALAFLVSTLTYRSQTNTLAIIESGGGILRNVSSLIATNEEHRQILRENSCLQTLLQHLKSHSLTIVSNACGTLWNLSARNAKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALIEELDAQHLSETFDNIDNLSPKASHRVKPRHKHNVYGDYDAVCRSDGYNPNGVGVRSPYMNTPVLSSPSSRDNRGNAESVRAERDRSLDRERRGFLPDGEAAKRMMQIPTSAAQIAVVMEEVQNMHLGMDDRSAGSTPDPHSVQDDMIRRQTAVHGHQNIYSYSKTDPSGRPCPMPKLEYRASNDSLNSVNSTDGYGKRGQMKPSVDSYSEDDEGKCCVYRKYPADLAHKIHNANHMEDDNGDLDTPINYSLKYSDEQLNSGRQSPSQNERWARPKLLDDEMKRPDQKPPRSQSPGYPMYTEGSSEGEDKPKKYQPRFVQQDLPAFRSRGSNEQISSGSSHGLNKKISQTICSVDDYADDKPTNYSERYSEEEQLEEQTPSYSMKYTEDHHVEQPIDYSLKYSEAPSKKGMFSHSKTSSAQSSAKEHLSQDSSSSVASLKNQGRQKQLHPSSAQSRSGPTRAVQKNPTCKAPTINQETLQTYCVEDTPICFSRGSSLSSLSSEEDEMESCKRNVNSASNYPTLPISEKQSTNNVAADQRTSESQSSVHYVRAKPPRHHLGHGDGSRHHKTVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESHSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPPRSTSVKQKVTVPPHTEKHDLAPRHAVVSAAVQKVQVLPDNDTLLHFATESTPDGFSCASSLSALSLDEPFIQKDVELKIMPPVHEDDHSIEAEPEMEDMHEPKVQEKSPATSEAAKDILDDSDDDDDTEILNACINSAMPTKSSRKPKKQSTSRIPPPVACKPSQLPVYKLLPPQNRGQPQKHVALAHGEDMPRVYCVEGTPINFSTATSLSDLTIDSPPNELAGMESSAPHVEASGQRRDTLPEGKSAEAKETGLSPPMQSALAENEGDDILAECINSAMPKSKIHKPFRVQKMPDQAQHPSTATGSLVQQDLEKKKPTSPVKPMPQSSEYRARMLKRPEANNSLADPATYPDKNKETRKQEPKVVIRDFADKPSNAEERTRPGFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFEDEDLDFSKEKAVLRKDKEQRKVPLLKCSVEQPANTNMVSTFQTAPTKPLQKTVFPQAPKENTVVVCDEKQKFSIEDTPVCFSRNSSLSSLSDIDQENNNKDCSHKDDVTQMEAPRPQASGYAPKAFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKQTPRSKTEESGVKEEKSMMADGILSEEPDLILDLTDTHSPISEQALSPDSESFDWKAIQEGANSIVSSLHQAAASLSRQGSSDSDSILSLKSGISIGSPFHLPLNQDDKPAPNKGPRILKPGEKSSIEAKKKEEETAKSLKGGKKVYKSLITGKPRPSLESMASQHRQAQAPVISRGRTMVHVPGVRSSSPSTSPVPKKPPPRGQMSKPPSQAPGAGSSPRTMKVPPSSEPSPASGPPSSQGGSSKASSRSGSRDSTPSRPVQQSLTRPMQSPGRASVSPGRNGLSPSNKLSQLPQLPRTASPSASSTKSSGSGRMAYTSPGRQLVQPTPTKQSGLPRSTSGIPRSESASKILNQCGPSKKAELSRMSSTKSSGSESDRSEKPGLVRQSTFIKEAPSPTLKRKLEESASFESLSPSSTSQSQTPVSSPSLPDMSLSLPYQGSGWTKAPQSQNSAENGDGKSLKRHDISRSHSESPSRLPINRTGTWKREHSKHSSSLPRVGTWKRTGSSSSILSASSESSEKGRSEDERQPTNPPQKSGKEGGLERKGTWRKAKGSETSYAPMSLDLQDQTGDAMSKSEDVWVRIEDCPINNPRSSKSPTASTPPVIDSLPIKGLACDRDSSESHSKLMSENAAMSHLGSETNLNLLRSSESLDKKVTDIKPAPSNPNIGPELHEFPVSERTPFSSTNSSKHSSPSGAVAARVSPFNYTPSPRKSSADGSTPRPSQIPTPISSNAKKRDTKGDTTESGSYIVTSV
InterPro domains: - IPR009223: Adenomatous polyposis coli protein repeat (repeat) [1223-1968]
- IPR009240: Adenomatous polyposis coli protein, 15 residue repeat (repeat) [988-1149]
- IPR009234: Adenomatous polyposis coli protein basic domain (domain) [2163-2504]
- IPR009224: SAMP (repeat) [1532-1989]
- IPR036149: APC, N-terminal coiled-coil domain superfamily (homologous_superfamily) [3-54]
- IPR011989: Armadillo-like helical (homologous_superfamily) [311-724]
- IPR016024: Armadillo-type fold (homologous_superfamily) [335-730]
- IPR032038: Adenomatous polyposis coli, N-terminal dimerisation domain (domain) [4-55]
- IPR000225: Armadillo (repeat) [325-716]
- IPR026818: Adenomatous polyposis coli (APC) family (family) [2-2745]
- IPR026831: Adenomatous polyposis coli protein (homologous_superfamily) [122-228]
- IPR041257: Adenomatous polyposis coli (APC) repeat (repeat) [378-451]
- IPR009232: EB-1 binding (domain) [2584-2739]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0032989 (cellular component morphogenesis), GO:0009968 (negative regulation of signal transduction), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0003170 (heart valve development), GO:0060041 (retina development in camera-type eye), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0048859 (formation of anatomical boundary), GO:0016043 (cellular component organization), GO:0048839 (inner ear development), GO:0006935 (chemotaxis), GO:0030901 (midbrain development), GO:0003157 (endocardium development), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0048736 (appendage development), GO:0010648 (negative regulation of cell communication), GO:0198738 (cell-cell signaling by wnt), GO:0032350 (regulation of hormone metabolic process), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0030917 (midbrain-hindbrain boundary development), GO:0031018 (endocrine pancreas development), GO:0009799 (specification of symmetry), GO:0035107 (appendage morphogenesis), GO:0030522 (intracellular receptor signaling pathway), GO:0010817 (regulation of hormone levels), GO:0061061 (muscle structure development), GO:0048598 (embryonic morphogenesis), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0055123 (digestive system development), GO:0019747 (regulation of isoprenoid metabolic process), GO:0048880 (sensory system development), GO:0016055 (Wnt signaling pathway), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0033333 (fin development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0035272 (exocrine system development), GO:0030656 (regulation of vitamin metabolic process), GO:0048666 (neuron development), GO:0007420 (brain development), GO:0033334 (fin morphogenesis), GO:0048568 (embryonic organ development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0003007 (heart morphogenesis), GO:0042692 (muscle cell differentiation), GO:0001501 (skeletal system development), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0007417 (central nervous system development), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0021532 (neural tube patterning), GO:0048858 (cell projection morphogenesis), GO:0007507 (heart development), GO:0035270 (endocrine system development), GO:0035282 (segmentation), GO:0071599 (otic vesicle development), GO:0048883 (neuromast primordium migration), GO:0010565 (regulation of cellular ketone metabolic process), GO:0048384 (retinoic acid receptor signaling pathway), GO:0048882 (lateral line development), GO:0021915 (neural tube development), GO:0051052 (regulation of DNA metabolic process), GO:0048562 (embryonic organ morphogenesis), GO:0055001 (muscle cell development), GO:0007423 (sensory organ development), GO:0030111 (regulation of Wnt signaling pathway), GO:0060485 (mesenchyme development), GO:0061053 (somite development), GO:0048546 (digestive tract morphogenesis), GO:0061008 (hepaticobiliary system development), GO:0030855 (epithelial cell differentiation), GO:0046890 (regulation of lipid biosynthetic process), GO:0009855 (determination of bilateral symmetry), GO:0022008 (neurogenesis), GO:0072132 (mesenchyme morphogenesis), GO:0060972 (left/right pattern formation), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0060429 (epithelium development), GO:0019216 (regulation of lipid metabolic process), GO:0048565 (digestive tract development), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0031016 (pancreas development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0048925 (lateral line system development), GO:0007368 (determination of left/right symmetry), GO:0048592 (eye morphogenesis), GO:0003197 (endocardial cushion development), GO:0043583 (ear development), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0048920 (posterior lateral line neuromast primordium migration), GO:0150063 (visual system development), GO:0001947 (heart looping), GO:0044030 (regulation of DNA methylation), GO:0007411 (axon guidance), GO:0033339 (pectoral fin development), GO:0001889 (liver development), GO:0048699 (generation of neurons), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:0048916 (posterior lateral line development), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043009 (chordate embryonic development), GO:0035118 (embryonic pectoral fin morphogenesis), GO:0001654 (eye development), GO:0046530 (photoreceptor cell differentiation), GO:0003203 (endocardial cushion morphogenesis), GO:0070365 (hepatocyte differentiation), GO:0120036 (plasma membrane bounded cell projection organization), GO:0003146 (heart jogging), GO:0031017 (exocrine pancreas development), GO:0031175 (neuron projection development), GO:0035138 (pectoral fin morphogenesis), GO:0021903 (rostrocaudal neural tube patterning), GO:0048881 (mechanosensory lateral line system development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0031290 (retinal ganglion cell axon guidance), GO:0007409 (axonogenesis), GO:0048915 (posterior lateral line system development), GO:0043010 (camera-type eye development), GO:0001754 (eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030427 (site of polarized growth), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005886 (plasma membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0044295 (axonal growth cone), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)