Protein: ERC protein 2 (CAZ-associated structural protein 1) (CAST1) (Cast) (Cytomatrix protein p110) (Q8K3M6)
Organism: Rattus norvegicus (Rat)
Function: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Subcellular location: Cytoplasm. Synapse. Presynaptic active zone {ECO:0000305|PubMed:12163476}. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density. Colocalizes with RIMS1 and BSN in early stages of synapse formation.
Sequence: MYGSARTISNPEGSPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLGGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKNDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECNKLEAQLKKAHNIEDDSRMNPEFADRLKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREFSMVDNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRMERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDEEGIWA
InterPro domains: - IPR019323: Active zone protein ELKS (family) [150-911]
Interaction partners: - Protein bassoon
- Protein unc-13 homolog B
- Regulating synaptic membrane exocytosis protein 2
- Regulating synaptic membrane exocytosis protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0033036 (macromolecule localization), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0099637 (neurotransmitter receptor transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0097120 (receptor localization to synapse), GO:0098969 (neurotransmitter receptor transport to postsynaptic membrane), GO:0006887 (exocytosis), GO:0071705 (nitrogen compound transport), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0015031 (protein transport), GO:0017157 (regulation of exocytosis), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0098877 (neurotransmitter receptor transport to plasma membrane), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0022607 (cellular component assembly), GO:1902414 (protein localization to cell junction), GO:0099003 (vesicle-mediated transport in synapse), GO:0065003 (protein-containing complex assembly), GO:1903539 (protein localization to postsynaptic membrane), GO:1990778 (protein localization to cell periphery), GO:1903540 (establishment of protein localization to postsynaptic membrane), GO:0035418 (protein localization to synapse), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098794 (postsynapse), GO:0048786 (presynaptic active zone), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0008021 (synaptic vesicle), GO:0098831 (presynaptic active zone cytoplasmic component), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0098984 (neuron to neuron synapse), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0099738 (cell cortex region), GO:0014069 (postsynaptic density), GO:0032279 (asymmetric synapse), GO:0097708 (intracellular vesicle)