Protein: Histone-lysine N-methyltransferase, H3 lysine-4 specific (Q6FKB1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
Function: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face
Subcellular location: Nucleus. Chromosome
Sequence: MSQYRRYFDESDPNQSRYSSRNGNGSYYQSRGSQRYNYEGQPDESGYRKDYQKSLGAGNGQYNNRQYSRNDNGSSNNVPQGRYTPTEYSSRRSFHHNDAEIKLPSAPSRVQYSYKARNSETKDPNAYRPNHTDQSYIRGRNSNGKSYGPVNIPTGPQQSRIVSNRNHNQHNVSLRPKATVKYKNIEQLTCKYHYFDPVEKVLTHRTEMKKWTEVNKDMPEVGFVVQQETINGQVKSVIKSRKPDEKSTDPRKTTIPNTGNSSTKKKQRTARKCRKELTLVPRISYDKFSLGPPPSTEVVVFAENFSNTQMANIPDISIKNYFRKFGELAHFASYSDPKTALPLHLYLVKYTHPSGKINDSAKAAYQAVKSCQEQKCCILGCNFNVLLNKNNELENIMNKRITVLSKETEKVKLQMEQEKKSALKKSAELNKEEKGILKPLKTIPGDLRPIVNNRPALYISRRFISVMGLRLIDFKSKLKAYKCSRFLEHATGFYIIFNNLEHAKLCMDAESGKLTMASRRKRTTVPINFILIEPFTSRFSKKYKDVPSDSKEKVEIVRYNNKEELIDAASKYIIEDLAKTLHTEIRKTMIGPAVFDTLQPSNFPQLVQKRKEQEELKKADMEKKKAEQAKSKDFNIFNLYASYTNKPKRRQKRYLSDEEAEEELPQKKIKPLAHLLDEVREDSPTSGLESTDDPTEGDNMSTSSSSEDEDDIMDDFQNEDKKDDMFSTPETNEEMDYHHKIDYRTENLIDKEIDDASQVNERYLPSATQFPVTVYPENTYDSEYIDTVSLFDLQDAIKDEEDMEFLKECLPAGEDLEFDDDNGLLEYRIWKIKQMADISQSSTNNELRLNNQTLDKTLFEKNIPFIASEFKHIPEKLKSSYLPHKRRVHEPLNTVSHHNESKEQSPDIAIKEKSVNKADTGEGSLAEISSSRDNRASNRRFQQNIEAQKAATGTESELLSLNQLNKRKKPVTFARSAIHNWGLYALEPINAKEMVIEYVGERIRQPVAEMRERRYIKNGIGSSYLFRIDEHTVIDATKKGGIARFINHCCEPSCTAKIIKVGGKRRIVIYALRDIAANEELTYDYKFERETDAEERLPCLCGAPSCKGFLN
InterPro domains: - IPR044570: Histone-lysine N-methyltransferase Set1-like (family) [869-1111]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [294-389]
- IPR046341: SET domain superfamily (homologous_superfamily) [866-1111]
- IPR024636: Histone lysine methyltransferase SET associated (domain) [458-521]
- IPR024657: COMPASS complex Set1 subunit, N-SET domain (domain) [781-963]
- IPR001214: SET domain (domain) [969-1092]
- IPR003616: Post-SET domain (domain) [1095-1111]
- IPR017111: Histone-lysine N-methyltransferase Set1, fungi (family) [1-1111]
- IPR048669: Histone-lysine N-methyltransferase SET1, RNA-binding domain (domain) [296-405]
Interaction partners: - Candida glabrata strain CBS138 chromosome G complete sequence
- Candida glabrata strain CBS138 chromosome D complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome K complete sequence
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Candida glabrata strain CBS138 chromosome L complete sequence
- Histone H4
- Histone H3
- Candida glabrata strain CBS138 chromosome M complete sequence
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0003723 (RNA binding), GO:0042054 (histone methyltransferase activity), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity), GO:0042800 (histone H3K4 methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0018205 (peptidyl-lysine modification), GO:0034968 (histone lysine methylation), GO:0018023 (peptidyl-lysine trimethylation), GO:0051568 (histone H3-K4 methylation), GO:0080182 (histone H3-K4 trimethylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)