Protein: Plasminogen (EC 3.4.21.7) (A6PVI2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRYFHCRCTYAGICNSDGKAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [625-782]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [592-824]
- IPR003609: PAN/Apple domain (domain) [20-114]
- IPR000001: Kringle (domain) [118-579]
- IPR013806: Kringle-like fold (homologous_superfamily) [107-580]
- IPR018056: Kringle, conserved site (conserved_site) [168-560]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [635-640]
- IPR038178: Kringle superfamily (homologous_superfamily) [118-577]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [771-782]
- IPR050759: Serine proteases and regulators with kringle domains (family) [386-825]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [583-826]
- IPR023317: Peptidase S1A, plasmin (family) [1-827]
- IPR001254: Serine proteases, trypsin domain (domain) [597-825]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0003823 (antigen binding), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0034185 (apolipoprotein binding), GO:0008233 (peptidase activity), GO:0005102 (signaling receptor binding), GO:0051087 (chaperone binding), GO:0017171 (serine hydrolase activity), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:1900047 (negative regulation of hemostasis), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0065008 (regulation of biological quality), GO:1900048 (positive regulation of hemostasis), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0050817 (coagulation), GO:1900046 (regulation of hemostasis), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0050818 (regulation of coagulation), GO:0030195 (negative regulation of blood coagulation), GO:0032103 (positive regulation of response to external stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:2000145 (regulation of cell motility), GO:0009611 (response to wounding), GO:0080134 (regulation of response to stress), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0030194 (positive regulation of blood coagulation), GO:0030155 (regulation of cell adhesion), GO:0032101 (regulation of response to external stimulus), GO:0030193 (regulation of blood coagulation), GO:0043170 (macromolecule metabolic process), GO:1903036 (positive regulation of response to wounding), GO:2000147 (positive regulation of cell motility), GO:0010632 (regulation of epithelial cell migration), GO:0050820 (positive regulation of coagulation), GO:0050878 (regulation of body fluid levels), GO:0007596 (blood coagulation), GO:0042127 (regulation of cell population proliferation), GO:0050819 (negative regulation of coagulation), GO:0007162 (negative regulation of cell adhesion), GO:0016043 (cellular component organization), GO:1903035 (negative regulation of response to wounding), GO:0032102 (negative regulation of response to external stimulus), GO:0010812 (negative regulation of cell-substrate adhesion), GO:0061045 (negative regulation of wound healing), GO:0006508 (proteolysis), GO:1903034 (regulation of response to wounding), GO:0010810 (regulation of cell-substrate adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0030334 (regulation of cell migration), GO:0045229 (external encapsulating structure organization), GO:0042060 (wound healing), GO:0010594 (regulation of endothelial cell migration), GO:0043062 (extracellular structure organization), GO:0090303 (positive regulation of wound healing), GO:0010634 (positive regulation of epithelial cell migration), GO:0030335 (positive regulation of cell migration), GO:0007599 (hemostasis), GO:0022408 (negative regulation of cell-cell adhesion), GO:0051917 (regulation of fibrinolysis), GO:0022411 (cellular component disassembly), GO:0022617 (extracellular matrix disassembly), GO:2000047 (regulation of cell-cell adhesion mediated by cadherin), GO:0010595 (positive regulation of endothelial cell migration), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0030198 (extracellular matrix organization), GO:0061041 (regulation of wound healing), GO:0043536 (positive regulation of blood vessel endothelial cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0072562 (blood microparticle), GO:0012505 (endomembrane system), GO:0005615 (extracellular space), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0019897 (extrinsic component of plasma membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043230 (extracellular organelle), GO:0009897 (external side of plasma membrane), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0060205 (cytoplasmic vesicle lumen), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0034774 (secretory granule lumen), GO:0031091 (platelet alpha granule), GO:0065010 (extracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0031093 (platelet alpha granule lumen), GO:0097708 (intracellular vesicle)