Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A5I9F0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MDVAAAALPAFVALWLLSPWPLLGSVQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGTMECYRVPVTYQNSLSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGVLVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [864-1439]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1061-1426]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [289-589]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [195-297]
- IPR003961: Fibronectin type III (domain) [290-594]
- IPR000998: MAM domain (domain) [30-193]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [33-191]
- IPR013098: Immunoglobulin I-set (domain) [200-277]
- IPR057598: Receptor-type tyrosine-protein phosphatase U-like, Fn3 domain (domain) [589-733]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [192-595]
- IPR007110: Immunoglobulin-like domain (domain) [195-280]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1039-1434]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1080-1384]
- IPR003599: Immunoglobulin domain subtype (domain) [200-288]
- IPR051622: Receptor-type Tyrosine-protein Phosphatases (family) [28-1238]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [886-1437]
Interaction partners: - Receptor protein-tyrosine kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0050807 (regulation of synapse organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0001750 (photoreceptor outer segment), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0005929 (cilium), GO:0030425 (dendrite), GO:0030424 (axon), GO:0097730 (non-motile cilium), GO:0097733 (photoreceptor cell cilium), GO:0097731 (9+0 non-motile cilium)