Protein: Transcription factor TBF1 (Q5AHJ5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters
Subcellular location: Nucleus. Chromosome, telomere
Sequence: MSDQLEKDIEESIANLDYQQNQEHHETEQDKDKEHQDVEKQSSEEETKGIEHVTDSNTDVIGVTKSQDTEEVIENSPVDPQLKEQQESTTKMSLSERDLVDEIDELFTNSTKTVTENNQPSETNKRAYESVETPQELTPNDKRQKLDANTETSVPTELESVNNHNEQSQPIEPTQERQPSTTETTYSISVPVSTANEVERASSSINEQEDLEMIAKQYQQATNLEIERAMEGHGDGGQHFSTQENGQPSGSSLISSIVPSDSELLNTNQAYAAYTSLSSQLEQHTSASAMLSSATLSALPLSIIAPVYLPPRIQLLINTLPTLDNLATQLLRTVATSPYQKIIDLASNPDTSAGATYRDLTSLFEFTKRLYSEDDPFLTVEHIAPGMWKEGEETPSIFKPKQQSIESTLRKVNLATFLAATLGTMEIGFFYLNESFLDVFCPSNNLDPSNALSNLGGYQNGLQSTDSPVGARVGKLLKPQATLYLDLKTQAYISAIEAGERSKEEILEDILPDDLHVYLMSRRNAKLLSPTETDFVWRCKQRKELLLNYTEETPLSEQYDWFTFLRDLFDYVSKNIAYLIWGKMGKTMKNRREDTPHTQELLDNTTGSTQMPNQLSSSSGQASSTPSVVDPNKMLVSEMREANIAVPKPSQRRAWSREEEKALRHALELKGPHWATILELFGQGGKISEALKNRTQVQLKDKARNWKKFFLRSGLEIPSYLRGVTGGVDDGKRKKDNVTKKTAAAPVPNMSEQLQQQQQRQQEKQEKQQQEEQQAQQSEQQQEPQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQREETQQTEQEQPDQPQEEQQQEKEQPDQQQQEKEQPDQQQPDQQHPDRQQQEQIQQPESSDK
InterPro domains: - IPR052833: Telomeric DNA-binding and transcriptional regulator (family) [170-886]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [649-712]
- IPR017930: Myb domain (domain) [651-703]
- IPR013867: Telomere repeat-binding factor, dimerisation domain (domain) [317-592]
- IPR001005: SANT/Myb domain (domain) [647-709]
Interaction partners: - Transcriptional regulator IFH1
- Fork-head transcriptional regulator FHL1
- DNA-binding protein RAP1
- Transcriptional regulator HMO1
- Transcription factor of morphogenesis MCM1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0042162 (telomeric DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0090304 (nucleic acid metabolic process), GO:0000723 (telomere maintenance), GO:0051276 (chromosome organization), GO:0032200 (telomere organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)