Protein: Meiotic recombination protein DMC1/LIM15 homolog (Q61880)
Organism: Mus musculus (Mouse)
Function: Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks
Subcellular location: Nucleus. Chromosome
Sequence: MKEDQVVQEESGFQDDEESLFQDIDLLQKHGINMADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVEKIKEAANKLIEPGFLTAFQYSERRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGTGGYSGGKIIFIDTENTFRPDRLRDIADRFNVDHEAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE
InterPro domains: - IPR010995: DNA repair Rad51/transcription factor NusA, alpha-helical (homologous_superfamily) [16-81]
- IPR020587: DNA recombination and repair protein RecA, monomer-monomer interface (domain) [277-340]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [83-340]
- IPR020588: DNA recombination and repair protein RecA-like, ATP-binding domain (domain) [97-270]
- IPR003593: AAA+ ATPase domain (domain) [118-307]
- IPR011940: Meiotic recombination protein Dmc1 (family) [24-338]
- IPR013632: Rad51-like, C-terminal (domain) [94-338]
- IPR016467: DNA recombination and repair protein, RecA-like (family) [18-340]
Interaction partners: - Breast cancer type 2 susceptibility protein homolog
- DNA repair protein RAD51 homolog 1
- Meiotic recombination protein SPO11
- Homologous-pairing protein 2 homolog
- Serine-protein kinase ATM
- Histone H2AX
- MutS protein homolog 4
- DNA repair protein RAD52 homolog
- DNA repair protein XRCC3
- Breast cancer type 1 susceptibility protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0021700 (developmental maturation), GO:1903046 (meiotic cell cycle process), GO:0048609 (multicellular organismal reproductive process), GO:0046660 (female sex differentiation), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048515 (spermatid differentiation), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0048608 (reproductive structure development), GO:0045132 (meiotic chromosome segregation), GO:0045137 (development of primary sexual characteristics), GO:0007283 (spermatogenesis), GO:0071695 (anatomical structure maturation), GO:0007059 (chromosome segregation), GO:0140013 (meiotic nuclear division), GO:0048469 (cell maturation), GO:0016043 (cellular component organization), GO:0009994 (oocyte differentiation), GO:0001541 (ovarian follicle development), GO:0007548 (sex differentiation), GO:0001556 (oocyte maturation), GO:0007140 (male meiotic nuclear division), GO:0061458 (reproductive system development), GO:0098813 (nuclear chromosome segregation), GO:0007141 (male meiosis I), GO:0048477 (oogenesis), GO:0008406 (gonad development), GO:0007286 (spermatid development), GO:0007127 (meiosis I), GO:0045143 (homologous chromosome segregation), GO:0046545 (development of primary female sexual characteristics), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0007129 (homologous chromosome pairing at meiosis), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0008585 (female gonad development), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000781 (chromosome, telomeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)