Protein: Ribosome biogenesis protein ERB1 (B6K1A5)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Function: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm
Sequence: MKEIQQQRKRKSEKLLDAVSGAQNEKENGSSFISDLKKHPVDEKENDQKINEDEDEDEVEEEEEGETSEDSFAGFESEEESLPELSPDVSEDESDIEEIDAGYSSDSSTEDGPARLYESPNEPGLYINYDIDGKRITRPATPAALDSLIASMDKGSGWTGIVDTATGQPVNLTDDEMKLLKRLAKTEIPEEGFNVYEDAVDFFTHNVQQTPVSSAPEPKSRFAPSKHERKRILQLAYAIKKGRILTAAQREELERKESERSFVADKDLWADDSAVNEMANHPMYAPAPRLPPPTHDESYNPPEEYLPTPEEAKAYEEADPEDRPKNYLPRKHNALRLVPAYKELLKERFERCLDLYLAPRVRRKKLNIDPESLIPKLPLPSELRPFPTRCTNAFVGHKGRVRSLDAHREGLWLASGGDDGVVRVWEILTGRCVWSMSLRNFNNGETSENDDDEDSTDEQSIIHAVAWSPNTATPILAVAADTKLYLITPPIFNPELVENAKNAVSQDFSESACVWKHCPKSLTTVLSGAVLHAVVTTQFTIKALSWHRRGDYVATSSSVSSNRAVIIHQLSRGASQSPFSKARGSIQQVSFHPTQPYLLVATQRYVRIYNLAKQELVKTLITGVKWISSIDVHPSGDHVLLGSYDRRLCWFDLDLSNKPYKTVRYHDRAIRDVSYHPTLPLFCSASDDGNVQVFHGRVYNDLMANPLIVPLKILGKHKVVNSVGVLDACWHPQEAWLFSCGANGEIRMWT
InterPro domains: - IPR012953: BOP1, N-terminal domain (domain) [126-387]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [390-750]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [377-750]
- IPR028598: WD repeat BOP1/Erb1 (family) [1-750]
- IPR001680: WD40 repeat (repeat) [387-750]
- IPR019775: WD40 repeat, conserved site (conserved_site) [413-427]
Interaction partners: - Pescadillo homolog
- Ribosome biogenesis protein Brx1
- Ribosome biogenesis protein YTM1
- ATP-dependent RNA helicase
- 60S ribosomal protein L7
- GTPase Grn1
- Nucleolar protein 16
- Ribosome biogenesis protein NSA1
- 60S ribosomal protein L8
- Ribosome assembly factor mrt4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0001817 (regulation of cytokine production), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032784 (regulation of DNA-templated transcription elongation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)