Protein: Toll-interacting protein (Q9QZ06)
Organism: Mus musculus (Mouse)
Function: Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9H0E2}. Endosome {ECO:0000250|UniProtKB:Q9H0E2}. Early endosome {ECO:0000250|UniProtKB:Q9H0E2}. Note=Localized to endo/exosomal vesicles. {ECO:0000250|UniProtKB:Q9H0E2}.
Sequence: MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGTVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [51-175]
- IPR003892: Ubiquitin system component CUE (domain) [229-272]
- IPR000008: C2 domain (domain) [35-154]
- IPR041799: Toll-interacting protein, CUE domain (domain) [230-270]
- IPR037301: Toll-interacting protein, C2 domain (domain) [52-172]
- IPR009060: UBA-like superfamily (homologous_superfamily) [220-271]
Interaction partners: - Interleukin-1 receptor-associated kinase 1
- Myeloid differentiation primary response protein MyD88
- Toll-like receptor 2
- Target of Myb1 membrane trafficking protein
- Interleukin-1 receptor-associated kinase 4
- Toll-like receptor 4
- TNF receptor-associated factor 6
- Toll/interleukin-1 receptor domain-containing adapter protein
- Interleukin-1 receptor type 1
- Interleukin-1 receptor accessory protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0019900 (kinase binding), GO:0030971 (receptor tyrosine kinase binding), GO:0019901 (protein kinase binding), GO:1990782 (protein tyrosine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051050 (positive regulation of transport), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0046907 (intracellular transport), GO:0032388 (positive regulation of intracellular transport), GO:0010646 (regulation of cell communication), GO:0060341 (regulation of cellular localization), GO:0006810 (transport), GO:0009966 (regulation of signal transduction), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0051222 (positive regulation of protein transport), GO:0045184 (establishment of protein localization), GO:0006886 (intracellular protein transport), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0071705 (nitrogen compound transport), GO:1904951 (positive regulation of establishment of protein localization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0070201 (regulation of establishment of protein localization), GO:0046824 (positive regulation of nucleocytoplasmic transport), GO:0071702 (organic substance transport), GO:0032880 (regulation of protein localization), GO:1900182 (positive regulation of protein localization to nucleus), GO:0008104 (protein localization), GO:0032386 (regulation of intracellular transport), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0042307 (positive regulation of protein import into nucleus), GO:0033157 (regulation of intracellular protein transport), GO:1900180 (regulation of protein localization to nucleus), GO:0046822 (regulation of nucleocytoplasmic transport), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0042306 (regulation of protein import into nucleus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)