Protein: Protein HIR2 (Q5AGM0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle
Subcellular location: Nucleus
Sequence: MKFLKLPQSYHNGGIHSIDVNQDNTILVSGGTDNKIGVWNLKKLIELSKLVSTHNSPEVRLKLKSLEPKQYITCHKSLINVVRFFKGDNKRFISSDVNGNVFFHTLHEQPETKQLFPFKSIETSEVNPVVDLTISADNRLIAWSTNNGKVYLYDVVKDTFQELTSICHEKPIIQRSIAFDPSNNYLITVGDDTQINVFQYSYEKDDTSTTTYKFRLIYKISKLFSQNPLNVRYKRISWSPDGNLVSIPTASKNQTMLISLISRSEKWTNIESLVGHDFACDVVKFNPKIFSSKENDTSKVHSVIASGGSDRTMAIWNTSKSTPITVLQDAVQGEILDITWTTDGTSLLFCTSQGKLCIGNFEPNELGYTFSQETMERFVQLQNNLIEPMNFRYPHEQTVGNRKQLPPIEFLSQKNAISTTTSSSNTVENDKKNAEDNVGVSNQSKSTTTTTTTTIKGGVITPEVIPPPKLQSLDDDIDGDGDDEEHKSGGMLDSVMNDRTQSSPRKLNKPKPIAPVVSDSTTQSLSFNKQKVTTKNGKRRIQPMLISSGNSAPSDLPRSNSVIKPVVNTTKSTMEFEKPSYSVSEEFYKQNKRPRTEETTGSNNNKKLKREMEPVKFIGSVILNPNTSFSKIRLATPKVRLFFQLKSKTDDDGVFILDIKNGSGNESKPSRLTYMKKDKEIWCDFIPKYIQLATEGSNFWAVTTVDGTILTYSHVSGKRLLPSIVLGSPISFLESYDKYLMVVTCIGELYVWDMEIKKNVLKSSISPLLELYNKEGLVKSDNITLCAVTSYGIPLVTLSNGSGYLFNKDLGVWQTITESWWCFGSHYWDSTQTGNSSGGGGGSGGSNNKRSLQTMNMFNDEQSIIELLEHKTNEEILRKTRTGRGKYFNKISKNMLMKEGFESLENTISISHLENRILCCELLGENKDFHKFFTTYVQRICELGFKAKLFEVCDELLGPIDTDTAKPPNENNWEPKICGFDKRELLKEIITSCSQFRDAQRVLVHFGKKIGVVIDES
InterPro domains: - IPR019015: HIRA B motif (conserved_site) [529-550]
- IPR031120: WD repeat HIR1-like (family) [1-1015]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [11-371]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [2-392]
- IPR001680: WD40 repeat (repeat) [1-360]
- IPR019775: WD40 repeat, conserved site (conserved_site) [27-41]
- IPR011494: Protein HIRA-like, C-terminal (domain) [717-956]
Interaction partners: - Histone transcription regulator 3 homolog
- Protein HIR1
- Histone chaperone ASF1
- Hpc2p
- Ubiquitin-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0003714 (transcription corepressor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)