Protein: Ribosomal protein S6 kinase (EC 2.7.11.1) (A0A384MDW3)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [66-717]
- IPR000961: AGC-kinase, C-terminal (domain) [328-397]
- IPR016239: Ribosomal protein S6 kinase II (family) [6-740]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [189-547]
- IPR041906: Ribosomal S6 kinase, N-terminal catalytic domain (domain) [72-388]
- IPR017892: Protein kinase, C-terminal (domain) [351-387]
- IPR017441: Protein kinase, ATP binding site (binding_site) [74-451]
- IPR000719: Protein kinase domain (domain) [68-679]
- IPR041905: Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain (domain) [402-740]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0030234 (enzyme regulator activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0043028 (cysteine-type endopeptidase regulator activity involved in apoptotic process), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0045927 (positive regulation of growth), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0001558 (regulation of cell growth), GO:0060255 (regulation of macromolecule metabolic process), GO:0030307 (positive regulation of cell growth), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0006793 (phosphorus metabolic process), GO:0099536 (synaptic signaling), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0043086 (negative regulation of catalytic activity), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043555 (regulation of translation in response to stress), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0043412 (macromolecule modification), GO:0034248 (regulation of amide metabolic process), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0043620 (regulation of DNA-templated transcription in response to stress), GO:0031326 (regulation of cellular biosynthetic process), GO:0099537 (trans-synaptic signaling), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0042981 (regulation of apoptotic process), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0043066 (negative regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006468 (protein phosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0018193 (peptidyl-amino acid modification), GO:0016310 (phosphorylation), GO:0098916 (anterograde trans-synaptic signaling), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006417 (regulation of translation), GO:0045861 (negative regulation of proteolysis), GO:0010608 (post-transcriptional regulation of gene expression), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0007268 (chemical synaptic transmission), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018105 (peptidyl-serine phosphorylation), GO:0018209 (peptidyl-serine modification), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0010951 (negative regulation of endopeptidase activity), GO:2000117 (negative regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)