Protein: Nucleolin (Protein C23) (P09405)
Organism: Mus musculus (Mouse)
Function: Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity).
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:P19338}. Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
Sequence: MVKLAKAGKTHGEAKKMAPPPKEVEEDSEDEEMSEDEDDSSGEEEVVIPQKKGKKATTTPAKKVVVSQTKKAAVPTPAKKAAVTPGKKAVATPAKKNITPAKVIPTPGKKGAAQAKALVPTPGKKGAATPAKGAKNGKNAKKEDSDEDEDEEDEDDSDEDEDDEEEDEFEPPIVKGVKPAKAAPAAPASEDEEDDEDEDDEEDDDEEEEDDSEEEVMEITTAKGKKTPAKVVPMKAKSVAEEEDDEEEDEDDEDEDDEEEDDEDDDEEEEEEEPVKAAPGKRKKEMTKQKEAPEAKKQKVEGSEPTTPFNLFIGNLNPNKSVNELKFAISELFAKNDLAVVDVRTGTNRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGRDSKKVRAARTLLAKNLSFNITEDELKEVFEDAMEIRLVSQDGKSKGIAYIEFKSEADAEKNLEEKQGAEIDGRSVSLYYTGEKGQRQERTGKTSTWSGESKTLVLSNLSYSATKETLEEVFEKATFIKVPQNPHGKPKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLELQGSNSRSQPSKTLFVKGLSEDTTEETLKESFEGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDFKPQGKKTKFE
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [299-674]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [306-652]
- IPR034234: Nucleolin, RNA recognition motif 3 (domain) [486-558]
- IPR034233: Nucleolin, RNA recognition motif 2 (domain) [392-467]
- IPR034235: Nucleolin, RNA recognition motif 4 (domain) [569-646]
- IPR000504: RNA recognition motif domain (domain) [309-644]
- IPR034230: Nucleolin, RNA recognition motif 1 (domain) [309-383]
Interaction partners: - Nucleophosmin
- 4-hydroxyphenylpyruvate dioxygenase
- Heterogeneous nuclear ribonucleoprotein K
- Y-box-binding protein 1
- rRNA 2'-O-methyltransferase fibrillarin
- Heterogeneous nuclear ribonucleoprotein U
- Midkine
- Calreticulin
- Collagen alpha-1
- Calreticulin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0043169 (cation binding), GO:0003677 (DNA binding), GO:0046872 (metal ion binding), GO:0043565 (sequence-specific DNA binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0033036 (macromolecule localization), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0044085 (cellular component biogenesis), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0002694 (regulation of leukocyte activation), GO:0001817 (regulation of cytokine production), GO:0045184 (establishment of protein localization), GO:0035295 (tube development), GO:0046907 (intracellular transport), GO:0002697 (regulation of immune effector process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0050865 (regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0003205 (cardiac chamber development), GO:0010033 (response to organic substance), GO:0050867 (positive regulation of cell activation), GO:0002831 (regulation of response to biotic stimulus), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002833 (positive regulation of response to biotic stimulus), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0071705 (nitrogen compound transport), GO:0055123 (digestive system development), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0006886 (intracellular protein transport), GO:0051251 (positive regulation of lymphocyte activation), GO:0007399 (nervous system development), GO:0015031 (protein transport), GO:0050729 (positive regulation of inflammatory response), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0051249 (regulation of lymphocyte activation), GO:1901215 (negative regulation of neuron death), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0045088 (regulation of innate immune response), GO:0060284 (regulation of cell development), GO:0002718 (regulation of cytokine production involved in immune response), GO:0010720 (positive regulation of cell development), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:1901214 (regulation of neuron death), GO:0010628 (positive regulation of gene expression), GO:0031060 (regulation of histone methylation), GO:2001020 (regulation of response to DNA damage stimulus), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0030323 (respiratory tube development), GO:0050727 (regulation of inflammatory response), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1902107 (positive regulation of leukocyte differentiation), GO:1901987 (regulation of cell cycle phase transition), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0048565 (digestive tract development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0050670 (regulation of lymphocyte proliferation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0065003 (protein-containing complex assembly), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0043523 (regulation of neuron apoptotic process), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0150063 (visual system development), GO:0043524 (negative regulation of neuron apoptotic process), GO:0051896 (regulation of protein kinase B signaling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0048699 (generation of neurons), GO:0031401 (positive regulation of protein modification process), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0043408 (regulation of MAPK cascade), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0033365 (protein localization to organelle), GO:0031399 (regulation of protein modification process), GO:0043066 (negative regulation of apoptotic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0022618 (ribonucleoprotein complex assembly), GO:0031175 (neuron projection development), GO:1902229 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:2000106 (regulation of leukocyte apoptotic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0031056 (regulation of histone modification), GO:0033077 (T cell differentiation in thymus), GO:0001745 (compound eye morphogenesis), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0060341 (regulation of cellular localization), GO:0051260 (protein homooligomerization), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005694 (chromosome), GO:0005634 (nucleus)