Protein: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 (Q504C1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence: MDVCVLFHLIVFCILISHISSECFPGCSCGTDRHGRSLTCMETALTGIPDGLPEDLTKIRIEKSQLSELPEAVFSHVKALKHLWLNFNDIAIINIKSLEGLANLTELRLQGNKLRSVPWTAFEETPNLKILDLKHNRIDALPEHALKFLPGLTYLDLSSNQLSVISKDVFLNWPLYHSENKHEKPSASNVVLALHDNPWLCDCRLGGFIEFIKSLTPPFILMNSYLTCSSPELKAGRFFHEVDLKTCVKPVVSAPVITITAPLGGNVTLTCSASARPEAVIRWIYALKMLRGFRDILSHVDEDTISSQLVIPSLHSADRGLYTCIANNFLGNSSVIISVDVKSPEGSSSHPSGPSAAIGEENVYIDIRIAKQTVYGITIEWRAVTENPAETWFTIHFGRYDAVKKEQIYIGPGINTYSVTDLLPATKYEICVTLKNQAPRIGQCIVFVTGSDFNEMEQREKLIHIVVIVLAMVLAVPAGMYACTTDAKFNCFERCAELWRNRRHAELSNPTGDRQGTFDSLQAASDEGLYKESNKDKKARRRSAEKIHKTKNDRRPTAELY
InterPro domains: - IPR050467: Leucine-rich repeat and fibronectin type-III domain-containing (family) [67-493]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [249-344]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [197-248]
- IPR007110: Immunoglobulin-like domain (domain) [250-342]
- IPR003598: Immunoglobulin subtype 2 (domain) [262-331]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [367-438]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [248-446]
- IPR003961: Fibronectin type III (domain) [366-438]
- IPR001611: Leucine-rich repeat (repeat) [103-172]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [52-172]
- IPR003599: Immunoglobulin domain subtype (domain) [256-342]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [20-247]
Interaction partners: - WD repeat domain 17
- Ankyrin repeat domain 33Ab
- Coiled-coil domain-containing 126
- Si:ch211-235e9.8
- G protein-activated inward rectifier potassium channel 3
- Grifin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060041 (retina development in camera-type eye), GO:0060900 (embryonic camera-type eye formation), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)