Protein: ADP,ATP carrier protein 3 (ADP/ATP translocase 3) (Adenine nucleotide translocator 3) (ANT 3) (P18238)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P18239}; Multi-pass membrane protein {ECO:0000269|PubMed:24474793}.
Sequence: MSSDAKQQETNFAINFLMGGVSAAIAKTAASPIERVKILIQNQDEMIKQGTLDKKYSGIVDCFKRTAKQEGLISFWRGNTANVIRYFPTQALNFAFKDKIKLMFGFKKEEGYGKWFAGNLASGGAAGALSLLFVYSLDFARTRLAADAKSSKKGGARQFNGLTDVYKKTLKSDGIAGLYRGFMPSVVGIVVYRGLYFGMFDSLKPLVLTGSLDGSFLASFLLGWVVTTGASTCSYPLDTVRRRMMMTSGQAVKYNGAIDCLKKIVASEGVGSLFKGCGANILRSVAGAGVISMYDQLQMILFGKKFK
InterPro domains: - IPR002113: ADP/ATP carrier protein, eukaryotic type (family) [5-306]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [9-304]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [4-307]
- IPR002067: Mitochondrial carrier protein (family) [15-245]
Interaction partners: - ADP,ATP carrier protein 2
- Cytochrome c isoform 2
- Eukaryotic translation initiation factor 5A-2
- Uncharacterized mitochondrial carrier YFR045W
- Non-selective voltage-gated ion channel 1
- Cytochrome c oxidase subunit 5B, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015215 (nucleotide transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015217 (ADP transmembrane transporter activity), GO:0005346 (purine ribonucleotide transmembrane transporter activity), GO:0005347 (ATP transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015216 (purine nucleotide transmembrane transporter activity), GO:0000295 (adenine nucleotide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0046148 (pigment biosynthetic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0042168 (heme metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0006839 (mitochondrial transport), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0071705 (nitrogen compound transport), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0071702 (organic substance transport), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0033013 (tetrapyrrole metabolic process), GO:0006811 (monoatomic ion transport), GO:0006783 (heme biosynthetic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0045333 (cellular respiration), GO:0033014 (tetrapyrrole biosynthetic process), GO:0006812 (monoatomic cation transport), GO:0015886 (heme transport), GO:0030001 (metal ion transport), GO:0009060 (aerobic respiration), GO:0006779 (porphyrin-containing compound biosynthetic process), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport), GO:1901678 (iron coordination entity transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031970 (organelle envelope lumen), GO:0070013 (intracellular organelle lumen), GO:0031966 (mitochondrial membrane), GO:0005758 (mitochondrial intermembrane space), GO:0005743 (mitochondrial inner membrane)