Protein: Mannosyl-oligosaccharide glucosidase (Q5AED0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Sequence: MTMDGSTPEEKRLKDIKFRQWGSYVGERQWATVREDYSADGDAWSALTFDDSRSRAYRWGEDGLAGVSDRKQFVNVTMALWNGKDPILKEKLFGVTNSQGNHGEDVKEQYYYLDNTPTHSYMKYLYKYPQNEYPYKQLVEENQKRSRLEKEFEITDTDIFKNNEYFDVVMESAKGDAPDELYFRITAYNRSDKAASLHILPHCTLRNIWSWGADEYQEVKKPHVKQIDEYTVEVETQKFGKRYLVFAPSPGFKESDPDVEPQLIFTENETNTKKLYNQDNKSKYVKDAFHEYVVDGKQEVVNPEKQGTKAAAWFTFKDIPAGEYVTIRYKFTNDKSEVDEFELDNIISKRQAEADEFYWHVTPYPISDELRQIQRQGFAGLLWTKQFYYFVHNYWANGDPDTIKPPMNRANGRNKEWKHLYTDEILSLPDKWEYPFFAAWDSAFHCIPFAMIDPRFAWMQLDHLVREWYMHPNGQIPAYEWNFSDVNPPVHAWAAYRVFKIERKMYGVESLDYLESIFQKLLINFTWWVNRKDAEGKNVFEGGFLGLDNIGVFNRSEELPTGGSLEQADSTGWMAFYSLQMLNIALELAKTRPVYENIASKFFEHFIIIADAMTFRGGDGDESTKDALWDDKDKFYYDAIRYSDHHVESLHVRSLVGLIPLYASLTIEPDLLNRYPSFKKRLNWFLVHQKKMSERNIASMETRGVGERMLLSLVSKDRLLAILDRMLNEDEFLSEYGIRSLSKYHKDHPYVKEVNGEKFTVAYLSGESDSGMFGGNSNWRGPIWFPTNFLLVEALQRFYLYYGPDLKVECPKGSGDYLNLAQCAQEIQHRLIRIFLPDEEGDRACNGGVDILNRDPLFKDYVPFYEYFDGDSGRGLGASHQTGWTSLVTKWIHDNAASNRVPRTPQTPKNRRRQSVFLHASEEANDDDEEELQKYVPKCGPMPGTLARRKSGKSLLNLTVNALDLGDEEGSATTKAAVCGQVGEGKSISEEELEKLHKVQSGASIDSNEAAQLDSDLLGQVRAAFKKFKSRTDEDEFEGDEFETRCS
InterPro domains: - IPR004888: Glycoside hydrolase family 63 (family) [19-894]
- IPR031335: Glycosyl hydrolase family 63, C-terminal (domain) [715-804]
- IPR012341: Six-hairpin glycosidase-like superfamily (homologous_superfamily) [404-901]
- IPR008928: Six-hairpin glycosidase superfamily (homologous_superfamily) [390-895]
- IPR054491: Mannosylglycerate hydrolase MGH1-like, glycoside hydrolase domain (domain) [434-540]
Interaction partners: - Glycogen debranching enzyme
- Meiotic sister chromatid recombination protein 1
- Tfs1p
- Phosphotransferase
- 17-beta-hydroxysteroid dehydrogenase-like protein
- Glutamate decarboxylase
- Phosphotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0005984 (disaccharide metabolic process), GO:0005991 (trehalose metabolic process), GO:0046352 (disaccharide catabolic process), GO:0009313 (oligosaccharide catabolic process), GO:0005993 (trehalose catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0009986 (cell surface)