Protein: Fork-head transcriptional regulator FHL1 (Q59ZC8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1
Subcellular location: Nucleus
Sequence: MSHIDGDDHMTKDLIDSLESKDNDLSLVTSNTQIPDVEVANLTHDADEINQLFDTATNNVLPESNKKDKPIDTQDLHEDDPKAVPKTTSNGESTSNSNSVSPKLLPNDGKSTPKIQKELRRKSTFVPVTSNSKSLEPSEDDNNNNNNNSRISAYARLDFENFTFFVQTLQVVLGRKSNDETLQQNVDVHLSSKKAISRRHAKIFYNFGTQRFEISILGRNGAFVDNVFVEKGLTIPLTDGNKIQIGDIPFKFVLPSNEPNEENNNQDSSEKQFNPSDAINLRSNLYSKSSSPQSSPKRKPQPSKKVKKEPVSASNTSKDIKPTPPVPTTAISPTASISTSTNAATAATATTPATTTAARKNSINRRNSLLKIRRLSNARRKSLAANDEINELLKDLGVTSIDEINEEDSELLDAQIQSLLDEDNENLGGIEDSLMKLAEFNESAIDDDDDDEEGNENSQADLDRLEKTMEHDAIDDEIKAIDSNLTLLDDEISKLTPLINDTNQGLLEEKETKKKQLEEEKRKKQLQQLQHKNSLAKFPRRSAPLMGKPASIQPPASSSIYSRINGLDKIGKTVSPRPPPPKLIAPVLRVTAEPSAIRSRPPLRAITVSDSSYIATFSYPKTIEEPSKYPKPKVKKEHHKKHSKKVYSLDEIPEPYRSKPNISFQIMITNVLKTEAARNGLIINEITEAIKEVYPYYKYCTDGWQFSINHCIKFTKIYKRLQKRGSEWLYAMDELYINERENIRIKQREIAKAKAKAEALRQEEIRQRQRLEAQKSLPHNIVGRNFASPYANTRVPPNQYNQFSQSSSSSSSSATTTTNGQYGSTTMVGGTSPQAGSIRAQLAAVRGNGNTPATTSTTPSLPAMNDPKTKKSLEYLQKELFTLYKARKLTYDTQTATSLITKAVATTIAQVNSIGAKAGAGDNALVFLVERAPEKVSKILDIALTKSIKEHEGIASKSPSQPATPGMRPEQLTTTSQSAATPTTTPQISNLQSLPVKPPISTPLPQVPQQQVSGVNIPGPIATPNIGVTSGVGNLGTTSIGTPTPTQIQSPATSVIPAMQSPQKPVSTPIPTSVPVPLPVPSAPLARPPSFGKPPGAGSSLSRPKAFGKPPGAGSSLSRPPTFLSNKPSYKRELEDDEEEGEQATNKIAKTE
InterPro domains: - IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [150-263]
- IPR000253: Forkhead-associated (FHA) domain (domain) [170-246]
- IPR053364: Fork-head Transcriptional Regulator (family) [13-1049]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [658-751]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [658-748]
- IPR001766: Fork head domain (domain) [657-740]
Interaction partners: - Transcriptional regulator IFH1
- Transcription factor TBF1
- Proteasome subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0019222 (regulation of metabolic process), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0098630 (aggregation of unicellular organisms), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0045785 (positive regulation of cell adhesion), GO:0090609 (single-species submerged biofilm formation), GO:0080090 (regulation of primary metabolic process), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010810 (regulation of cell-substrate adhesion), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042710 (biofilm formation), GO:0051252 (regulation of RNA metabolic process), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0010468 (regulation of gene expression), GO:1900187 (regulation of cell adhesion involved in single-species biofilm formation), GO:0090605 (submerged biofilm formation), GO:2001141 (regulation of RNA biosynthetic process), GO:1900189 (positive regulation of cell adhesion involved in single-species biofilm formation), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)