Protein: AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) (Q9Y6Q5)
Organism: Homo sapiens (Human)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Subcellular location: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Sequence: MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWIKHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDFGFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRAHFGLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDYQLRTS
InterPro domains: - IPR036168: AP-2 complex subunit mu, C-terminal superfamily (homologous_superfamily) [157-421]
- IPR018240: Clathrin adaptor, mu subunit, conserved site (conserved_site) [157-267]
- IPR028565: Mu homology domain (domain) [157-422]
- IPR011012: Longin-like domain superfamily (homologous_superfamily) [4-140]
- IPR050431: Adaptor complexes medium subunit (family) [3-421]
- IPR022775: AP complex, mu/sigma subunit (domain) [5-135]
- IPR001392: Clathrin adaptor, mu subunit (family) [2-423]
Interaction partners: - AP-1 complex subunit sigma-2
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit gamma-1
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit beta-1
- AP-1 complex subunit sigma-3
- AP-2 complex subunit beta
- AP-1 complex subunit mu-1
- Aftiphilin
- AP-4 complex subunit beta-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0033059 (cellular pigmentation), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0048066 (developmental pigmentation), GO:0043476 (pigment accumulation), GO:0046907 (intracellular transport), GO:0030154 (cell differentiation), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0050931 (pigment cell differentiation), GO:0048753 (pigment granule organization), GO:0032438 (melanosome organization), GO:0006996 (organelle organization), GO:0016050 (vesicle organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0031984 (organelle subcompartment), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0032588 (trans-Golgi network membrane), GO:0012506 (vesicle membrane), GO:0005802 (trans-Golgi network), GO:0065010 (extracellular membrane-bounded organelle), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0005774 (vacuolar membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0005764 (lysosome), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0098852 (lytic vacuole membrane), GO:0035579 (specific granule membrane), GO:0005765 (lysosomal membrane)