Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit) (Q9D6J5)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000269|PubMed:38575788}.
Sequence: MAAARAAALGVRWLQRTTRGVVPLEARRAFHMTKDMLPGSYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPMLPNRSQHERDPWYQWDHSELRMNWGEPIHWDLDMYIRNRVDTSPTPVSWDVMCKHLFGFVAFMVFMFWVGHVFPSYQPVGPKQYPYNNLYLERGGDPTKEPEPVVHYDI
InterPro domains: - IPR016551: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa (family) [1-186]
- IPR008699: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 (family) [1-186]
Interaction partners: - NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase 1 alpha subcomplex subunit 11
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH dehydrogenase 1 beta subcomplex subunit 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0022804 (active transmembrane transporter activity), GO:0008137 (NADH dehydrogenase (ubiquinone) activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0003008 (system process), GO:0048522 (positive regulation of cellular process), GO:0120161 (regulation of cold-induced thermogenesis), GO:0070887 (cellular response to chemical stimulus), GO:0044057 (regulation of system process), GO:0071495 (cellular response to endogenous stimulus), GO:0008217 (regulation of blood pressure), GO:1901700 (response to oxygen-containing compound), GO:0120162 (positive regulation of cold-induced thermogenesis), GO:0003013 (circulatory system process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0097305 (response to alcohol), GO:0032870 (cellular response to hormone stimulus), GO:1901654 (response to ketone), GO:0008015 (blood circulation), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0110096 (cellular response to aldehyde), GO:0048545 (response to steroid hormone), GO:0003015 (heart process), GO:0045777 (positive regulation of blood pressure), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:1903522 (regulation of blood circulation), GO:1901655 (cellular response to ketone), GO:0008016 (regulation of heart contraction), GO:0045471 (response to ethanol), GO:0071383 (cellular response to steroid hormone stimulus), GO:0031960 (response to corticosteroid), GO:0097306 (cellular response to alcohol), GO:0071398 (cellular response to fatty acid), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0051385 (response to mineralocorticoid), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071389 (cellular response to mineralocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)