Protein: Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) (Q9BXF6)
Organism: Homo sapiens (Human)
Function: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Subcellular location: Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion membrane; Peripheral membrane protein.
Sequence: MALVRGAEPAAGPSRWLPTHVQVTVLRARGLRGKSSGAGSTSDAYTVIQVGREKYSTSVVEKTHGCPEWREECSFELPPGALDGLLRAQEADAGPAPWAASSAAACELVLTTMHRSLIGVDKFLGQATVALDEVFGAGRAQHTQWYKLHSKPGKKEKERGEIEVTIQFTRNNLSASMFDLSMKDKPRSPFSKIRDKMKGKKKYDLESASAILPSSAIEDPDLGSLGKMGKAKGFFLRNKLRKSSLTQSNTSLGSDSTLSSASGSLAYQGPGAELLTRSPSRSSWLSTEGGRDSAQSPKLFTHKRTYSDEANQMRVAPPRALLDLQGHLDAASRSSLCVNGSHIYNEEPQGPVRHRSSISGSLPSSGSLQAVSSRFSEEGPRSTDDTWPRGSRSNSSSEAVLGQEELSAQAKVLAPGASHPGEEEGARLPEGKPVQVATPIVASSEAVAEKEGARKEERKPRMGLFHHHHQGLSRSELGRRSSLGEKGGPILGASPHHSSSGEEKAKSSWFGLREAKDPTQKPSPHPVKPLSAAPVEGSPDRKQSRSSLSIALSSGLEKLKTVTSGSIQPVTQAPQAGQMVDTKRLKDSAVLDQSAKYYHLTHDELISLLLQRERELSQRDEHVQELESYIDRLLVRIMETSPTLLQIPPGPPK
InterPro domains: - IPR019018: Rab-binding domain FIP-RBD (domain) [586-648]
- IPR035892: C2 domain superfamily (homologous_superfamily) [18-185]
- IPR000008: C2 domain (domain) [5-148]
- IPR037245: FIP-RBD, C-terminal domain superfamily (homologous_superfamily) [618-649]
- IPR037789: Rab11-family interacting protein class I (family) [1-522]
Interaction partners: - Ras-related protein Rab-11A
- Ras-related protein Rab-25
- Ras-related protein Rab-11B
- Rab11 family-interacting protein 2
- Rab11 family-interacting protein 3
- Rab11 family-interacting protein 1
- EH domain-containing protein 1
- Rab11 family-interacting protein 4
- Unconventional myosin-Vb
- Kinesin-like protein KIF3A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0043207 (response to external biotic stimulus), GO:0006952 (defense response), GO:0033500 (carbohydrate homeostasis), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0045184 (establishment of protein localization), GO:0098542 (defense response to other organism), GO:0055082 (intracellular chemical homeostasis), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0023061 (signal release), GO:0035592 (establishment of protein localization to extracellular region), GO:0009743 (response to carbohydrate), GO:0034097 (response to cytokine), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0071310 (cellular response to organic substance), GO:0009914 (hormone transport), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0046879 (hormone secretion), GO:0006887 (exocytosis), GO:0015031 (protein transport), GO:0042593 (glucose homeostasis), GO:0016192 (vesicle-mediated transport), GO:0034341 (response to type II interferon), GO:0008104 (protein localization), GO:0001678 (intracellular glucose homeostasis), GO:1901701 (cellular response to oxygen-containing compound), GO:0071322 (cellular response to carbohydrate stimulus), GO:0071333 (cellular response to glucose stimulus), GO:0034284 (response to monosaccharide), GO:0071345 (cellular response to cytokine stimulus), GO:0042886 (amide transport), GO:0015833 (peptide transport), GO:0002790 (peptide secretion), GO:0071692 (protein localization to extracellular region), GO:0030073 (insulin secretion), GO:0071346 (cellular response to type II interferon), GO:0045055 (regulated exocytosis), GO:0030072 (peptide hormone secretion), GO:0071326 (cellular response to monosaccharide stimulus), GO:0009746 (response to hexose), GO:0071331 (cellular response to hexose stimulus), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)