Protein: Spliceosome-associated factor 1, recruiter of U4/U6.U5 tri-snRNP (Q6DG11)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MGSSKKHKEKEKDRDPEERHREHKKHKHKDRDKEKDRDREKRKRSRSRERSSRGAEKDRSGKSEKSSAEPRVKKEKLDPAFEDNSEPGPKSASGDASLSIEETNKLRAKLGLKPLDLNENKKEAGTKEEPLLAETINPVQLKQQAEMREKLAALKEKRLLNQKLGKVKALGDDEPWLDDTAAWVERSRKLAKEKEMAEKRAKLLEEMDEEFGVSNLVEQEFAQEKRQAYSSHDLKGLKVQHKVESFSEGQTVVLTLQDKGVLEEEEDVLVNVGLIDKEKAEKNVELKKKKPDYKPYEEEESVDDMIVFKPKSVLSKYDEEIEGEKKKSFRLSSGGFVGGERERELQAIRESLRDQAQSLSTSALTLATEYYTPQEMVGFKKTKRKVKKIRKKEKVPRADELLVDDTRNSDFGSRSRGRGRKAADEEEEAVPGDVVIENISKSRNVLQQSDDIRMADMDISDEEDFVPPEPSALEEDEAEQELQKQLEKQRLLRQKQMLKDSGERVIERMKQLRARGDDDNDPDKRNNIVFNATSEFCRTLGDIPTYGLSGNREDQEDIMDFEKDDEKEGGGQSDSDMDDNVGWSTVNLDEEKNQADFSTASTTILDEEPIVNSGLAAALLLCKNKGLLDTQMQKVARVKAPKPVLANDNYCIEDKMHIDDKYSRREEYRGFTQDFKEKDNYKPDVKIEYVDESGRKLCPKEAFRQLSHRFHGKGSGKMKTERRMKKLEEEALLKKMSSSDTPLGTVALLQEKQKSQKTPYIVLSGSGKSMNANTITK
InterPro domains: - IPR045347: HIND motif (conserved_site) [97-115]
- IPR005011: SNU66/SART1 family (family) [26-775]
Interaction partners: - Pre-mRNA-processing factor 6
- Zinc finger matrin-type protein 2
- U4/U6 small nuclear ribonucleoprotein Prp31
- Activating signal cointegrator 1 complex subunit 3
- U4/U6 small nuclear ribonucleoprotein Prp4
- Pre-mRNA-processing-splicing factor 8
- U6 snRNA-associated Sm-like protein LSm6
- Small nuclear ribonucleoprotein polypeptide A'
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0048513 (animal organ development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0048568 (embryonic organ development), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0001701 (in utero embryonic development), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)