Protein: Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (P0C2H4)
Organism: Bos taurus (Bovine)
Function: Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305|PubMed:16505484}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9UL01}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9UL01}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}. Microsome membrane {ECO:0000269|PubMed:16505484}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL01}.
Sequence: MRTHTRGAPSVFFICLFCFVSACVTDENPEVMIPFTNANYDSHPMLYFSRAEVAELQLRAASSHEHIAARLTEAVNTMLSSPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENMEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQEKFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLVLMNQGYLQEAYLWTKQVLTIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKSVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTFFNNVLMFSPAASKSCFSPWEGQVTEDCSSKWSKYKHDPAASCQGRVVAAVEKNGVVFIRGEGVGAYNPQLHLRNVQRNLILLHPQLLLLVDQIHLGEDSPLERAASFFHNVDFPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKGTFASVTYPRGYPYNGTNYVNVTTHLRSPVTRAAYLFIGPSIDVQSFSIHGDAQQLDVFVATSEHAYATYLWTGETAGQSAFAQVIADRQKILFDRSSAIRSSVVPEVKDYAALVEQNLQHFKPVFQLLEKQILSRVRNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQQQQQSKSKKNRRGGKRYKFVDAVPDIFAQIEVNERKVRQKAQILAQKELPVDEDEEMKDLLDFADITYEKHKNGDVMNGRFGQARMVTTHSRAPALSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCILLWLYSSCSQSQC
InterPro domains: - IPR008929: Chondroitin AC/alginate lyase (homologous_superfamily) [40-381]
- IPR052447: Dermatan-Sulfate Isomerase (family) [5-724]
- IPR032518: Heparinase II, N-terminal (domain) [149-314]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016854 (racemase and epimerase activity), GO:0016857 (racemase and epimerase activity, acting on carbohydrates and derivatives)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0034035 (purine ribonucleoside bisphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)