wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Nectin cell adhesion molecule 3 (A0A8I5ZU75)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane {ECO:0000256|ARBA:ARBA00004162}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MARTPGPALLCPGGGKAQLSSASPPAAGLLLPAPTPPPLLLLLIPLLLFSRLCGALAGSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTVAVHHPQYGFSVQGEYQGRILFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLMKGPDSLIDGGNETVAAVCIAATGKPVARIDWEGDLGEMESTITSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGEWPDGLLASDNTLHFVHPLTFNYSGVYVCKVTNSLGQRSDQKVIYISDPPTTTTLQPTVQWRSSTADVQDLATEHKKLPFPLSTLATLKDDTIGTIIASVVGGALFVVLVSILAGVFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQHDEHDSYPDSVKKENKAPVNNLIRKDYLEEPEKTQWNNVENLTRFERPMDYYEDLKMGMKFVSDERYNENEDDLVSHVDGSVISRREWYV
InterPro domains: - IPR051427: Nectin and Nectin-like (family) [38-549]
- IPR013106: Immunoglobulin V-set domain (domain) [63-167]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [64-362]
- IPR033320: Nectin-3/4, second Ig domain (domain) [170-265]
- IPR013162: CD80-like, immunoglobulin C2-set (domain) [176-256]
- IPR007110: Immunoglobulin-like domain (domain) [37-354]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [59-364]
- IPR033319: Nectin-3, immunoglobulin variable domain 1 (domain) [58-167]
- IPR003599: Immunoglobulin domain subtype (domain) [63-167]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0030507 (spectrin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0050807 (regulation of synapse organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030425 (dendrite), GO:0030424 (axon)
Protein: LIM domain containing 2 (J3QQM5)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MFQAAGAAQATPSHDAKGGGSSTVQRSKSFSLRAQVKETCAACQKTVYPMERLVADKLIFHNSCFCCKHCHTKLSLGSYAALHGEFYCKPHFQQLFKSKGNYDEGFGRK
InterPro domains: - IPR001781: Zinc finger, LIM-type (domain) [38-98]
- IPR044115: LIMD2, LIM domain (domain) [40-92]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0033554 (cellular response to stress), GO:0000165 (MAPK cascade), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0051403 (stress-activated MAPK cascade), GO:0007254 (JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: 14-3-3 protein eta (Protein AS1) (Q04917)
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Sequence: MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN
InterPro domains: - IPR023409: 14-3-3 protein, conserved site (conserved_site) [42-235]
- IPR036815: 14-3-3 domain superfamily (homologous_superfamily) [1-246]
- IPR000308: 14-3-3 protein (family) [1-246]
- IPR023410: 14-3-3 domain (domain) [4-246]
Interaction partners: - RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase B-raf
- M-phase inducer phosphatase 3
- M-phase inducer phosphatase 2
- Serine/threonine-protein kinase A-Raf
- Transcriptional coactivator YAP1
- Bcl2-associated agonist of cell death
- 14-3-3 protein zeta/delta
- 14-3-3 protein gamma
- 14-3-3 protein beta/alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0019900 (kinase binding), GO:0003723 (RNA binding), GO:0005159 (insulin-like growth factor receptor binding), GO:0019901 (protein kinase binding), GO:0005080 (protein kinase C binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0010646 (regulation of cell communication), GO:0048167 (regulation of synaptic plasticity), GO:0099177 (regulation of trans-synaptic signaling), GO:0045664 (regulation of neuron differentiation), GO:0050804 (modulation of chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0030055 (cell-substrate junction), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005925 (focal adhesion), GO:1903561 (extracellular vesicle)
Protein: Glutathione S-transferase domain-containing protein (B0G141)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Sequence: MVMKLYTYPQNSRAFKSLIAAKYVNVDIEVPAFNFETDRLTEEFKTNFPLGKVPALLTEQGPLFESNTMARYVARLNNSTIYGSDAYTAALNDQWIDYAANEIDPNAIPWLYAILGYYDYNAKDSNKAKENMKKVLAFLDAQLLNKPFLTGFRVALADIIVVCSLFNFYKMVFEPTFRSPYVNVNRWFTTCINQPNFKAVIGEFALCEKMMVYVAPKKEVKEEKPKAAPKKEVKEDAGDDEVDEKPKKKNPLDELAPSTFVLDEFKRTYSNNEVSMSIPWFFEHFDKEGFSVYQCTYQYNHELGPVFKTCNLVGGFFQRLETLHKYAFASMIIFGEEQGGAVKDQTVSGLWVFRGQDLPADMKDCDDSLVYDWKKLDVAADKAIIESFLAWEDKNGGFAGKKFLQGKLYK
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [1-76]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [72-211]
- IPR050802: Elongation Factors and Glutathione S-transferases (family) [1-410]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [105-195]
- IPR036433: Elongation factor EF1B gamma, C-terminal domain superfamily (homologous_superfamily) [248-410]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [85-220]
- IPR040079: Glutathione transferase family (family) [3-191]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [1-81]
- IPR001662: Elongation factor 1B gamma, C-terminal (domain) [247-410]
Interaction partners: - Elongation factor 1b-related protein
- Elongation factor 1-alpha
- Elongation factor 1-beta
- Elongation factor 1-alpha
- Elongation factor 1b-related protein
- Elongation factor 2
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein eS7
- Elongation factor 2
- Large ribosomal subunit protein eL6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0030312 (external encapsulating structure), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle)
Protein: RGG repeats nuclear RNA binding protein A (Q9SQ56)
Organism: Nicotiana tabacum (Common tobacco)
Function: Binds RNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:11905967}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O23523}.
Sequence: RGGGRGGPRGGGRGRGPGRGRGFNQESADDENAFGSNNGFSGRYRVQEDGESGKLSERRGGYGGPRGGFHGGRRGGFNNGDAAEGEGERPRRVFDRRSGTGRGNEYIKREGSGRGNWGTPADDIAQETEVPVNDGEKIVEAEKEAGQEEAEDTNKDSTAAEPEEKEPEEKEMTLEEYEKLMEEKRKALLALKPEERKVNLDKELESMQLLSNKKNDDEIFIKLGSEKEKRKEAVEKARKTQSINEFLKPAEGENYSRRGGRGRGPGRGRGGFGGGVGGNKSFSAPSIEDVGQFPSLVAK
InterPro domains: - IPR006861: Hyaluronan/mRNA-binding protein (domain) [90-199]
- IPR039764: RNA binding protein HABP4/SERBP1-like (family) [3-296]
Interaction partners: - 40S ribosomal protein S25
- 40S ribosomal protein S25
- 60S ribosomal protein L29
- 60S ribosomal protein L29
- 40S ribosomal protein S28-like
- 40S ribosomal protein S28
- 60S ribosomal protein L38
- 60S ribosomal protein L38
- 40S ribosomal protein S29
- 40S ribosomal protein S29-like
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0032069 (regulation of nuclease activity), GO:0051336 (regulation of hydrolase activity), GO:0060700 (regulation of ribonuclease activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pinin (F1QT45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell junction, desmosome {ECO:0000256|ARBA:ARBA00004568}. Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
Sequence: MAVAVRSLQDQLEKAKEGLKSVDENIRKLTGRDPGELRPGQNRRLTIPGPGGGRGRGINLLRRGLSDSGGGPPAKLRDIDGALLRLAGDQRARRDSRHDSDAEDDDDVKKPALQSSVVATSKERTRRDLIQDQTMDERGKQRNRRMFGLLMGTLQKFKQESTVSTERLKRRQEIEQKLEVQAEQERKKVECERRELFEERRAKQTELRLLEHKVELAQLQEDWNAHNSKLIKFIRTKTKPPIFYLPGRMCSATQKLLEESQKKLNGVFDERREAFAEQINKMEARPRRQSQRTGDKEMEGSRRAEETKKEDQEEGKAGAGRAGNRHVVEMEDEDEDVVEEEAEESSEVRERDEDQEQEQEQGEEKEEKNEESERKAEEDEEEEDEDPGAVEVKEDEEEQMEVTEVVGEVEAQGKLQVESPEATVEEVGNVRIEEEQEVESETQQEVTADSQQTPESQTETQPEESKEPQADAPSPNETQQDSKEEEAAVPESQQLQAEPEPEPEVPSQEPSQELSEEPQAAKTDTKEAGEEADDARGRAKVRAKKSKSRSSSSSSSSSSSSSSSSGSSSSSSGSSSSSSGSSSSSSSRSRSRGRDRENRDHKRRRRPSDRERRRSGSERAHKSSKSSGREGKGSKDKTSKPDRKRTSSEGRRSRSERDRKSDRKDRR
InterPro domains: - IPR006787: Pinin/SDK (domain) [1-133]
- IPR006786: Pinin/SDK/MemA protein (domain) [138-262]
- IPR039853: Pinin (family) [1-401]
Interaction partners: - Histone deacetylase complex subunit SAP18
- RNA-binding protein with serine-rich domain 1
- PNN-interacting serine/arginine-rich protein.
- Apoptotic chromatin condensation inducer 1a.
- Eukaryotic initiation factor 4A-III
- Serine/arginine repetitive matrix 1.
- Protein mago nashi homolog
- Zinc finger CCHC domain-containing protein 17
- LUC7-like 3 pre-mRNA-splicing factor.
- Apoptotic chromatin condensation inducer 1b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0048762 (mesenchymal cell differentiation), GO:0048863 (stem cell differentiation), GO:0060485 (mesenchyme development), GO:0014033 (neural crest cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) (P50752)
Organism: Mus musculus (Mouse)
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Sequence: MSDAEEVVEEYEEEQEEEDWSEEEEDEQEEAVEEEEAGGAEPEPEGEAETEEANVEEVGPDEEAKDAEEGPVEDTKPKPSRLFMPNLVPPKIPDGERVDFDDIHRKRVEKDLNELQTLIEAHFENRKKEEEELISLKDRIEKRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKALAIDHLNEDQLREKAKELWQSIHNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
InterPro domains: - IPR027707: Troponin T (family) [1-301]
- IPR001978: Troponin (family) [106-293]
- IPR038077: Troponin domain superfamily (homologous_superfamily) [176-301]
Interaction partners: - Troponin C, slow skeletal and cardiac muscles
- Troponin I, cardiac muscle
- Troponin I, slow skeletal muscle
- Troponin I, fast skeletal muscle
- Myosin-6
- Tropomyosin alpha-1 chain
- Troponin C, skeletal muscle
- Myosin-binding protein C, cardiac-type
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Actin, alpha cardiac muscle 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0043502 (regulation of muscle adaptation), GO:0044057 (regulation of system process), GO:0090257 (regulation of muscle system process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0036379 (myofilament), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0005865 (striated muscle thin filament), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: histidine kinase (EC 2.7.13.3) (E0TZB4)
Organism: Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) (Bacillus subtilis subsp. spizizenii)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISSYEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEVVGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEVVGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQQDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA
InterPro domains: - IPR000700: PAS-associated, C-terminal (domain) [325-379]
- IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [432-601]
- IPR003660: HAMP domain (domain) [201-256]
- IPR049814: Response regulator WalK (family) [6-600]
- IPR057640: WalK sensor protein kinase, Chache domain (domain) [76-168]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [488-602]
- IPR000014: PAS domain (domain) [263-369]
- IPR005467: Histidine kinase domain (domain) [383-602]
- IPR036097: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (homologous_superfamily) [362-443]
- IPR004358: Signal transduction histidine kinase-related protein, C-terminal (domain) [527-599]
- IPR003661: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (domain) [374-443]
- IPR035965: PAS domain superfamily (homologous_superfamily) [250-368]
- IPR001610: PAC motif (repeat) [328-370]
- IPR050351: Sensor protein kinase GraS-like (family) [1-605]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0070297 (regulation of phosphorelay signal transduction system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: T3SS secreted effector NleH (Q8X831)
Organism: Escherichia coli O157:H7
Function: Not known
Sequence: MLSPYSVNLGCSWNSLTRNLTSPDNRVLSSVRDAAVHSDNGAQVKVGNRTYRVVATDNKFCVTRESHSGCFTNLLHRLGWPKGEISRKIEVMLNASPVSAAMERGIVHSNRPDLPPVDYAPPELPSVDYNRLSVPGNVIGKGGNAVVYEDAEDATKVLKMFTTSQSNEEVTSEVRCFNQYYGAGSAEKIYGNNGDIIGIRMDKINGESLLNISSLPAQAEHAIYDMFDRLEQKGILFVDTTETNVLYDRAKNEFNPIDISSYNVSDRSWSESQIMQSYHGGKQDLISVVLSKI
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [136-270]
- IPR054466: Kinase OspG, kinase domain (domain) [138-261]
Interaction partners: - T3SS secreted effector NleH
- T3SS secreted effector NleH
- T3SS secreted effector NleD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0035821 (modulation of process of another organism), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0044238 (primary metabolic process), GO:0051701 (biological process involved in interaction with host), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044003 (modulation by symbiont of host process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006796 (phosphate-containing compound metabolic process), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm)