Protein: Acetyltransferase component of pyruvate dehydrogenase complex (F6NRK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety. The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle
Subcellular location: Mitochondrion matrix
Sequence: MLRLVLRVRPSARLTRPSVLSGPAAAPAASPRPGPVSCHHLKRYHSSGPARIRSSFHGRRVCNSILSNRSWGLRSQTAAFSQSMRVYSLPPHQKVELPALSPTMQMGTIARWEKKEGDKINEGDLIAEVETDKATVGFEMLEECYLAKILVAEGTRDVPIGAVICITVDKPELISSFKDFTLDKITSSAPAAAAPPPPATPTSAPAAPQVPGSSYPPHMKVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKIMISEGTRDVPLGTPLCIIVEKESDISAFADYVETGVAASPPPAPTPVATPPPAAAPAAPIPAPAAAPAAPAAARKGRVFASPLAKKLAAEKGVDITQVTGTGPDGRVTKKDIDSFVPPKLAPAAAAAPSAPTPSPPAAPAYAAVPTGTFTDVPISNIRKVIAQRLMQSKQTIPHYYLSIDVNMDQVLELRKELNAEVKAENIKLSVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPVGLITPIVFNAHIKGLANISKDVSALAAKARDGKLQPHEFQGGTFTISNLGMYGIKHFSAIINPPQACILAVGGSEKRLLPADNEKGFDVANMMSVTLSCDHRVVDGAVGAQWLAEFRKFLEKPFTMLL
InterPro domains: - IPR045257: Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component (family) [221-652]
- IPR000089: Biotin/lipoyl attachment (domain) [92-294]
- IPR004167: Peripheral subunit-binding domain (domain) [353-391]
- IPR006257: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (family) [220-652]
- IPR011053: Single hybrid motif (homologous_superfamily) [92-312]
- IPR023213: Chloramphenicol acetyltransferase-like domain superfamily (homologous_superfamily) [409-649]
- IPR003016: 2-oxo acid dehydrogenase, lipoyl-binding site (binding_site) [117-272]
- IPR036625: E3-binding domain superfamily (homologous_superfamily) [347-392]
- IPR001078: 2-oxoacid dehydrogenase acyltransferase, catalytic domain (domain) [423-652]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0004738 (pyruvate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051606 (detection of stimulus), GO:0044238 (primary metabolic process), GO:0009581 (detection of external stimulus), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009314 (response to radiation), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0009582 (detection of abiotic stimulus), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0050906 (detection of stimulus involved in sensory perception), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0050877 (nervous system process), GO:0043603 (amide metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0009416 (response to light stimulus), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0050962 (detection of light stimulus involved in sensory perception), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0035384 (thioester biosynthetic process), GO:0007600 (sensory perception), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006637 (acyl-CoA metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0009583 (detection of light stimulus), GO:0050953 (sensory perception of light stimulus), GO:0009117 (nucleotide metabolic process), GO:0009584 (detection of visible light), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0006084 (acetyl-CoA metabolic process), GO:0050908 (detection of light stimulus involved in visual perception), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0071616 (acyl-CoA biosynthetic process), GO:0007601 (visual perception), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0034033 (purine nucleoside bisphosphate biosynthetic process), GO:0006085 (acetyl-CoA biosynthetic process), GO:0033875 (ribonucleoside bisphosphate metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0033866 (nucleoside bisphosphate biosynthetic process), GO:0006086 (acetyl-CoA biosynthetic process from pyruvate), GO:0034030 (ribonucleoside bisphosphate biosynthetic process), GO:0006090 (pyruvate metabolic process), GO:0009152 (purine ribonucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)