Protein: Transcriptional enhancer factor TEF-5 (A0A2R8QCP0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Subcellular location: Nucleus
Sequence: MDKTGMDGDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKMREYQAGIKAMNLDQASKDKALQNMAALSSAQIVSASVMKSQLPPLPQHPYPPPARFWPGPIPGQPGPSQDIKPFAPSPYPTLQPPPISSYEQLPAPLPPSATAVPVWQDRTIASSKLRMLEYSAFMEVQRDPDTYSKHLFVHIAQTNPSYTDPLLEAVDIRQIYDKFPEKKGGLKELYEKGPQNAFFLVKFWADLNSSNVQDGAGSFYGVSSQYSSAENMTITVSTKVCSFGKQVVEKVETEYARVEGGRYVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAFVFEVSTSDHGAQYHVYRLVKD
InterPro domains: - IPR050937: TEC1/TEAD Transcription Factor (family) [6-409]
- IPR041086: YAP binding domain (domain) [196-406]
- IPR016361: Transcriptional enhancer factor, metazoa (family) [4-409]
- IPR038096: TEA/ATTS domain superfamily (homologous_superfamily) [6-87]
- IPR027253: Transcriptional enhancer factor TEF-5 (TEAD3) (family) [2-409]
- IPR000818: TEA/ATTS domain (domain) [5-83]
Interaction partners: - Transcriptional coactivator YAP1
- WW domain-containing transcription regulator 1
- Vestigial-like 4 like
- Liprin-alpha-4
- Golgi transport 1A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0032990 (cell part morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)