Protein: Solute carrier family 41 member 2 (Q96JW4)
Organism: Homo sapiens (Human)
Function: Acts as a plasma-membrane magnesium transporter. Can also mediate the transport of other divalent metal cations in an order of Ba(2+) > Ni(2+) > Co(2+) > Fe(2+) > Mn(2+) (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MTNSKGRSITDKTSGGPSSGGGFVDWTLRLNTIQSDKFLNLLLSMVPVIYQKNQEDRHKKANGIWQDGLSTAVQTFSNRSEQHMEYHSFSEQSFHANNGHASSSCSQKYDDYANYNYCDGRETSETTAMLQDEDISSDGDEDAIVEVTPKLPKESSGIMALQILVPFLLAGFGTVSAGMVLDIVQHWEVFRKVTEVFILVPALLGLKGNLEMTLASRLSTAVNIGKMDSPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLDHSILLCSSSVATAFIASLLQGIIMVGVIVGSKKTGINPDNVATPIAASFGDLITLAILAWISQGLYSCLETYYYISPLVGVFFLALTPIWIIIAAKHPATRTVLHSGWEPVITAMVISSIGGLILDTTVSDPNLVGIVVYTPVINGIGGNLVAIQASRISTYLHLHSIPGELPDEPKGCYYPFRTFFGPGVNNKSAQVLLLLVIPGHLIFLYTIHLMKSGHTSLTIIFIVVYLFGAVLQVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLIGDRDGDVGD
InterPro domains: - IPR036739: SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily (homologous_superfamily) [154-562]
- IPR006667: SLC41A/MgtE, integral membrane domain (domain) [200-556]
- IPR045349: SLC41A divalent cation transporter (family) [47-565]
Interaction partners: - Transient receptor potential cation channel subfamily M member 6
- Transient receptor potential cation channel subfamily M member 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015095 (magnesium ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0010035 (response to inorganic substance), GO:0034220 (monoatomic ion transmembrane transport), GO:0070887 (cellular response to chemical stimulus), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0071241 (cellular response to inorganic substance), GO:0006811 (monoatomic ion transport), GO:0010960 (magnesium ion homeostasis), GO:0032026 (response to magnesium ion), GO:0071248 (cellular response to metal ion), GO:0006812 (monoatomic cation transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0015693 (magnesium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)