Protein: Melanophilin (Exophilin-3) (Leaden protein) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) (Q91V27)
Organism: Mus musculus (Mouse)
Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
Subcellular location: Melanosome.
Sequence: MGKRLDLSTLTDEEAEHVWAVVQRDFDLRRREEERLQGLKGKIQKESSKRELLSDTAHLNETHCARCLQPYRLLLNSRRQCLECSLFVCKSCSHAHPEEQGWLCDPCHLARVVKIGSLEWYYQHVRARFKRFGSAKVIRSLCGRLQGGGGSEPSLEEGNGDSEQTDEDGDLDTEARDQPLNSKKKKRLLSFRDVDFEEDSDHLVQPCSQTLGLSSVPESAHSLQSLSGEPYSEDTTSLEPEGLEETGARALGCRPSPEVQPCSPLPSGEDAHAELDSPAASCKSAFGTTAMPGTDDVRGKHLPSQYLADVDTSDEDSIQGPRAASQHSKRRARTVPETQILELNKRMSAVEHLLVHLENTVLPPSAQEPTVETHPSADTEEETLRRRLEELTSNISGSSTSSEDETKPDGTFLGGSPKVCTDTGHMETQERNPRSPGNPARPTKSTDEELSEMEDRVAMTASEVQQAESEISDIESRIAALRAAGLTVKPSGKPRRKSGIPIFLPRVTEKLDRIPKTPPADPDDQAKMPKATTAVPSLLRRKYSPSSQGVDSGSFDRKSVYRGSLTQRNPNGRRGTARHIFAKPVMAQQP
InterPro domains: - IPR041282: FYVE-type zinc finger (domain) [8-125]
- IPR051745: Intracellular Transport Effector (family) [1-406]
- IPR037442: Melanophilin, FYVE-related domain (domain) [62-137]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [8-133]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1-146]
- IPR010911: Rab-binding domain (domain) [4-124]
- IPR006788: Rab effector MyRIP/Melanophilin (domain) [445-497]
Interaction partners: - Ras-related protein Rab-27A
- Unconventional myosin-Va
- Ras-related protein Rab-27B
- RILP-like protein 2
- Synaptotagmin-like protein 2
- Unconventional myosin-VIIa
- Tyrosinase
- Ras-related protein Rab-3A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0051020 (GTPase binding), GO:0017022 (myosin binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0007017 (microtubule-based process), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0051656 (establishment of organelle localization), GO:0051647 (nucleus localization), GO:0007097 (nuclear migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0001750 (photoreceptor outer segment), GO:0036477 (somatodendritic compartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0030425 (dendrite), GO:0030424 (axon), GO:0097730 (non-motile cilium), GO:0005634 (nucleus), GO:0097733 (photoreceptor cell cilium), GO:0097731 (9+0 non-motile cilium)