Protein: F-actin-capping protein subunit alpha (Q9W2N0)
Organism: Drosophila melanogaster (Fruit fly)
Function: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0PFK5}.
Sequence: MEQTPITDAEKVRIVSDFILHAPPGEFNEVFNDVRELLKNDTLLKDGASHAFAQYNKDQLTPVRIEGTDHNAIISEHNDLGNGRFYDPRTKQAFKYDHLRKEASDYQDVEADATAEPWRAALDLETLAYTASHYRHGVSSVFGKAQGNQITLTICIEDHQFQPKNYWNGRWRSQWHVTFQAGSGTAELKGVLKVQVHYYEDGNVQLVSSKECRESVVVSNEQQVAKEVIRLIEDAENEYQLAISENYQTMSDTTFKAMRRQLPITRTKIDWSKIVSYSIGKELKTQ
InterPro domains: - IPR042489: F-actin capping protein, alpha subunit, domain 1 (homologous_superfamily) [2-110]
- IPR042276: F-actin-capping protein subunit alpha/beta, domain 2 (homologous_superfamily) [112-258]
- IPR037282: F-actin-capping protein subunit alpha/beta (homologous_superfamily) [6-281]
- IPR002189: F-actin-capping protein subunit alpha (family) [5-284]
- IPR017865: F-actin capping protein, alpha subunit, conserved site (conserved_site) [196-266]
Interaction partners: - F-actin-capping protein subunit beta
- Dynactin subunit 2
- Leucine-rich repeat, isoform F
- Actin-related protein 10, isoform A
- Actin-related protein 1
- Dynactin subunit 4
- CIN85 and CD2AP related, isoform J
- Adenylyl cyclase-associated protein
- 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
- WASH complex subunit 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007292 (female gamete generation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0048477 (oogenesis), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0098862 (cluster of actin-based cell projections), GO:0043229 (intracellular organelle), GO:0005903 (brush border), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)