Protein: DNA ligase 4 (P52496)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair. Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae
Subcellular location: Nucleus
Sequence: MTYFLNDIRPPSPNDITPSFTLLTKELFDKLDGVRKESLGDFRTVTEKKAFIIKTFINTFRTHIGNDIYPSAKLIFPEKSGRIYFIKEVALARLLIKMYKIPKESEDYITLHDWNKSYQRSRRFSIDEKKIRDLPLQASRIISKRRPIVDKLEEYTVPQINSSLDQLALEKVSQGQIDILKPLFDNLSIPEVRWLIHILLNKSILTSMERFFFNTWHPDGYRVFSICNDLQKTLQFSTNPDLRLDPSQLAIHPCFKFKPQLSERLTTSYKTLVKKLQRKHEMDPPYEKKFQELGLENKFYIEEKMDGDRMLLHKDGDSFKFFSRRLKDYSYLYGESFQFGALTKFLAHAFAGNIQSVILDGEMVAYDYERNVILPFGTLKSSAIQESVRQFTTIDQYEQQTAYPFFLVFDILFLNGKDLTNYPLFFRKNILNRILRPIPNRFEVLDTRLGSSSEDIERAIREVVSSRCEGLVLKNVQSKYEIDGFRNPDWIKVKPEYLEKFGENLDLVVIGKSPAIKNSYMCGLKSVTDGVYYSFCTCANGIEIEEFDKIERLTHGKWIKTDVSMPPESLIKFGTKIPTFWIHPSDSLVLEIRARSIDTRAGTSYAVGSTLHNNHCRKIREDKSIDECVTLQEYTHIKANYINDLNKAQTALGKKREPVYSLDNESKLKKVKVESDLFSGIEFLIMSDKREADGEVTTIEEMKAMVKQYGGKIVNSVDLATNYQIMVITERELPVSSQYLSKGIDLVKPIWIYECIKRGCVLQLEPYFIFASKNWDNFNHMVDQYGDSYIIHHPLNIVVPKLSESELEDLRNGFDWGDLKPWIYLFKGLSFYVCGNNLSARFLKERIERFSGDLSKHFIECCYIVIPDNHSRPLMLREIDKMSNQISREMVIDKNGGSSRIPHFVTEAFVQASIKMNYIPDPDDYKFR
InterPro domains: - IPR036599: DNA ligase, ATP-dependent, N-terminal domain superfamily (homologous_superfamily) [17-247]
- IPR044125: DNA Ligase 4, adenylation domain (domain) [248-499]
- IPR001357: BRCT domain (domain) [673-917]
- IPR029710: DNA ligase 4 (family) [16-927]
- IPR000977: DNA ligase, ATP-dependent (family) [83-707]
- IPR012310: DNA ligase, ATP-dependent, central (domain) [276-526]
- IPR016059: DNA ligase, ATP-dependent, conserved site (conserved_site) [302-494]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [497-641]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [667-784]
- IPR012308: DNA ligase, ATP-dependent, N-terminal (domain) [23-217]
Interaction partners: - ATP-dependent DNA helicase II subunit 2
- DNA helicase
- DNA repair and recombination protein RAD52
- Proliferating cell nuclear antigen
- Serine/threonine-protein kinase TOR
- Pso2p
- DNA repair protein RAD51 homolog
- Flap endonuclease 1
- DNA repair and recombination protein RAD52
- Double-strand break repair protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016886 (ligase activity, forming phosphoric ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0003909 (DNA ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006310 (DNA recombination), GO:0035825 (homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0140535 (intracellular protein-containing complex), GO:0043229 (intracellular organelle), GO:1990391 (DNA repair complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)