Protein: Alpha-2A adrenergic receptor (Alpha-2A adrenoreceptor) (Alpha-2A adrenoceptor) (Alpha-2AAR) (Alpha-2D adrenergic receptor) (CA2-47) (P22909)
Organism: Rattus norvegicus (Rat)
Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
InterPro domains: - IPR001946: Alpha 2A adrenoceptor (family) [21-463]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [65-441]
- IPR002233: Adrenoceptor family (family) [103-456]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [50-456]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-11
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alpha-2B adrenergic receptor
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:1901338 (catecholamine binding), GO:0019900 (kinase binding), GO:0001664 (G protein-coupled receptor binding), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0031690 (adrenergic receptor binding), GO:0019901 (protein kinase binding), GO:0004935 (adrenergic receptor activity), GO:0004936 (alpha-adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0007267 (cell-cell signaling), GO:0023056 (positive regulation of signaling), GO:0051051 (negative regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0035556 (intracellular signal transduction), GO:0046887 (positive regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0044057 (regulation of system process), GO:0050673 (epithelial cell proliferation), GO:0010647 (positive regulation of cell communication), GO:0008217 (regulation of blood pressure), GO:0003013 (circulatory system process), GO:0090066 (regulation of anatomical structure size), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0003018 (vascular process in circulatory system), GO:0051952 (regulation of amine transport), GO:0045776 (negative regulation of blood pressure), GO:0008015 (blood circulation), GO:0003073 (regulation of systemic arterial blood pressure), GO:0032890 (regulation of organic acid transport), GO:0045777 (positive regulation of blood pressure), GO:0051046 (regulation of secretion), GO:1903522 (regulation of blood circulation), GO:0035150 (regulation of tube size), GO:0097746 (blood vessel diameter maintenance), GO:0035296 (regulation of tube diameter), GO:0019229 (regulation of vasoconstriction), GO:0006940 (regulation of smooth muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0009986 (cell surface), GO:0044327 (dendritic spine head), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0044306 (neuron projection terminus), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0043195 (terminal bouton), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0005634 (nucleus), GO:0030424 (axon), GO:0044309 (neuron spine)