Protein: Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132) (P34902)
Organism: Mus musculus (Mouse)
Function: Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P31785}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P31785}.
Sequence: MLKLLLSPRSFLVLQLLLLRAGWSSKVLMSSANEDIKADLILTSTAPEHLSAPTLPLPEVQCFVFNIEYMNCTWNSSSEPQATNLTLHYRYKVSDNNTFQECSHYLFSKEITSGCQIQKEDIQLYQTFVVQLQDPQKPQRRAVQKLNLQNLVIPRAPENLTLSNLSESQLELRWKSRHIKERCLQYLVQYRSNRDRSWTELIVNHEPRFSLPSVDELKRYTFRVRSRYNPICGSSQQWSKWSQPVHWGSHTVEENPSLFALEAVLIPVGTMGLIITLIFVYCWLERMPPIPPIKNLEDLVTEYQGNFSAWSGVSKGLTESLQPDYSERFCHVSEIPPKGGALGEGPGGSPCSLHSPYWPPPCYSLKPEA
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [57-248]
- IPR003961: Fibronectin type III (domain) [154-254]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [56-255]
- IPR053856: Cytokine receptor-like factor 2-like, domain 1 (domain) [60-146]
- IPR048648: Cytokine receptor-like factor 2-like, D2 domain (domain) [154-248]
- IPR003531: Short hematopoietin receptor, family 1, conserved site (conserved_site) [214-247]
Interaction partners: - Interleukin-7
- Interleukin-15
- Interleukin-2 receptor subunit alpha
- Interleukin-9
- Interleukin-4 receptor subunit alpha
- Interleukin-4
- Interleukin-2 receptor subunit beta
- Tyrosine-protein kinase JAK3
- Interleukin-2
- Interleukin-15 receptor subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050794 (regulation of cellular process), GO:0042221 (response to chemical), GO:0051050 (positive regulation of transport), GO:0006955 (immune response), GO:0032879 (regulation of localization), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007166 (cell surface receptor signaling pathway), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0050766 (positive regulation of phagocytosis), GO:0034097 (response to cytokine), GO:0050764 (regulation of phagocytosis), GO:0071310 (cellular response to organic substance), GO:0019221 (cytokine-mediated signaling pathway), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)