Protein: Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] (P02652)
Organism: Homo sapiens (Human)
Function: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
Subcellular location: Secreted {ECO:0000269|PubMed:24116940}.
Sequence: MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ
InterPro domains: - IPR036172: Apolipoprotein A-II (ApoA-II) superfamily (homologous_superfamily) [25-100]
- IPR006801: Apolipoprotein A-II (ApoA-II) (family) [1-100]
Interaction partners: - Apolipoprotein C-III
- Apolipoprotein B-100
- Apolipoprotein E
- Apolipoprotein A-I
- Apolipoprotein C-II
- Apolipoprotein A-IV
- Apolipoprotein D
- Apolipoprotein C-I
- Beta-2-glycoprotein 1
- Phosphatidylcholine-sterol acyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008289 (lipid binding), GO:0050997 (quaternary ammonium group binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0005543 (phospholipid binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0031210 (phosphatidylcholine binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0019899 (enzyme binding), GO:0008047 (enzyme activator activity), GO:0030695 (GTPase regulator activity), GO:0070325 (lipoprotein particle receptor binding), GO:0051020 (GTPase binding), GO:0046872 (metal ion binding), GO:0120020 (cholesterol transfer activity), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:1905953 (negative regulation of lipid localization), GO:0051051 (negative regulation of transport), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0097006 (regulation of plasma lipoprotein particle levels), GO:0034381 (plasma lipoprotein particle clearance), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0071827 (plasma lipoprotein particle organization), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0051049 (regulation of transport), GO:0051129 (negative regulation of cellular component organization), GO:0044085 (cellular component biogenesis), GO:0045833 (negative regulation of lipid metabolic process), GO:1905952 (regulation of lipid localization), GO:0044092 (negative regulation of molecular function), GO:0034369 (plasma lipoprotein particle remodeling), GO:0060627 (regulation of vesicle-mediated transport), GO:0031324 (negative regulation of cellular metabolic process), GO:0010876 (lipid localization), GO:0009894 (regulation of catabolic process), GO:0006629 (lipid metabolic process), GO:0045806 (negative regulation of endocytosis), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0010984 (regulation of lipoprotein particle clearance), GO:0062014 (negative regulation of small molecule metabolic process), GO:0032369 (negative regulation of lipid transport), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0034377 (plasma lipoprotein particle assembly), GO:0051128 (regulation of cellular component organization), GO:0030100 (regulation of endocytosis), GO:0043086 (negative regulation of catalytic activity), GO:0010565 (regulation of cellular ketone metabolic process), GO:1903726 (negative regulation of phospholipid metabolic process), GO:0051055 (negative regulation of lipid biosynthetic process), GO:0051336 (regulation of hydrolase activity), GO:0031330 (negative regulation of cellular catabolic process), GO:0071702 (organic substance transport), GO:0032368 (regulation of lipid transport), GO:0046890 (regulation of lipid biosynthetic process), GO:0022607 (cellular component assembly), GO:0006869 (lipid transport), GO:0050995 (negative regulation of lipid catabolic process), GO:0045922 (negative regulation of fatty acid metabolic process), GO:0048261 (negative regulation of receptor-mediated endocytosis), GO:0031326 (regulation of cellular biosynthetic process), GO:0050994 (regulation of lipid catabolic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0043933 (protein-containing complex organization), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0019216 (regulation of lipid metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0015914 (phospholipid transport), GO:0015850 (organic hydroxy compound transport), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0051346 (negative regulation of hydrolase activity), GO:0015748 (organophosphate ester transport), GO:0032371 (regulation of sterol transport), GO:0065003 (protein-containing complex assembly), GO:0042304 (regulation of fatty acid biosynthetic process), GO:0034367 (protein-containing complex remodeling), GO:0071825 (protein-lipid complex subunit organization), GO:0015918 (sterol transport), GO:0019220 (regulation of phosphate metabolic process), GO:1903725 (regulation of phospholipid metabolic process), GO:0060191 (regulation of lipase activity), GO:0045717 (negative regulation of fatty acid biosynthetic process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0019217 (regulation of fatty acid metabolic process), GO:0060192 (negative regulation of lipase activity), GO:0030301 (cholesterol transport), GO:0034368 (protein-lipid complex remodeling), GO:0065005 (protein-lipid complex assembly), GO:0032374 (regulation of cholesterol transport), GO:0051004 (regulation of lipoprotein lipase activity), GO:0033344 (cholesterol efflux)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032994 (protein-lipid complex), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0034358 (plasma lipoprotein particle), GO:0005783 (endoplasmic reticulum), GO:1990777 (lipoprotein particle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034364 (high-density lipoprotein particle), GO:0034385 (triglyceride-rich plasma lipoprotein particle), GO:0034361 (very-low-density lipoprotein particle)