Protein: Glycogen synthase kinase-3 (EC 2.7.11.26) (Q9U2Q9)
Organism: Caenorhabditis elegans
Function: Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension.
Sequence: MNKQLLSCSLKSGKQVTMVVASVATDGVDQQVEISYYDQKVIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRNPDARLPSGRPLPTLEMDGPMGTGEVSTTSGDVAGPSA
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [35-340]
- IPR050591: Glycogen Synthase Kinase-3 (family) [12-339]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [157-169]
- IPR039192: Glycogen synthase kinase 3, catalytic domain (domain) [31-323]
- IPR017441: Protein kinase, ATP binding site (binding_site) [42-66]
- IPR000719: Protein kinase domain (domain) [36-320]
Interaction partners: - Beta-catenin/armadillo-related protein 1
- Beta-catenin-like protein hmp-2
- Axin-like protein pry-1
- cAMP-dependent protein kinase catalytic subunit
- Armadillo repeat-containing protein wrm-1
- Serine/threonine-protein kinase akt-1
- Serine/threonine-protein kinase akt-2
- DiSHevelled related
- Adenomatous polyposis coli protein-related protein 1
- DiSHevelled related
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:2000241 (regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0033036 (macromolecule localization), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0021700 (developmental maturation), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0090068 (positive regulation of cell cycle process), GO:0009798 (axis specification), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0009880 (embryonic pattern specification), GO:0090598 (male anatomical structure morphogenesis), GO:0045787 (positive regulation of cell cycle), GO:0006793 (phosphorus metabolic process), GO:0071695 (anatomical structure maturation), GO:0009894 (regulation of catabolic process), GO:0051726 (regulation of cell cycle), GO:0051445 (regulation of meiotic cell cycle), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0048469 (cell maturation), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0009790 (embryo development), GO:0002164 (larval development), GO:0009994 (oocyte differentiation), GO:0001556 (oocyte maturation), GO:0080090 (regulation of primary metabolic process), GO:0051446 (positive regulation of meiotic cell cycle), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0009896 (positive regulation of catabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035282 (segmentation), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0045836 (positive regulation of meiotic nuclear division), GO:0048477 (oogenesis), GO:0010506 (regulation of autophagy), GO:0006796 (phosphate-containing compound metabolic process), GO:0007350 (blastoderm segmentation), GO:0009948 (anterior/posterior axis specification), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0000578 (embryonic axis specification), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0002119 (nematode larval development), GO:0010638 (positive regulation of organelle organization), GO:0007351 (tripartite regional subdivision), GO:0051174 (regulation of phosphorus metabolic process), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0051783 (regulation of nuclear division), GO:0061013 (regulation of mRNA catabolic process), GO:0030162 (regulation of proteolysis), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006468 (protein phosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0018193 (peptidyl-amino acid modification), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:0008595 (anterior/posterior axis specification, embryo), GO:0045862 (positive regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:0051785 (positive regulation of nuclear division), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0042327 (positive regulation of phosphorylation), GO:0018210 (peptidyl-threonine modification), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018105 (peptidyl-serine phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0018107 (peptidyl-threonine phosphorylation), GO:0018209 (peptidyl-serine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0097546 (ciliary base), GO:0005829 (cytosol), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030425 (dendrite), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)