wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Hemolysin E (Cytotoxin ClyA) (Silent hemolysin SheA) (Q8Z727)
Organism: Salmonella typhi
Function: Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells (By similarity).
Subcellular location: Secreted {ECO:0000250}. Periplasm {ECO:0000250}. Host cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Exported from the cell by outer membrane vesicles. Also found in the periplasmic space (By similarity). {ECO:0000250}.
Sequence: MTGIFAEQTVEVVKSAIETADGALDLYNKYLDQVIPWKTFDETIKELSRFKQEYSQEASVLVGDIKVLLMDSQDKYFEATQTVYEWCGVVTQLLSAYILLFDEYNEKKASAQKDILIRILDDGVKKLNEAQKSLLTSSQSFNNASGKLLALDSQLTNDFSEKSSYFQSQVDRIRKEAYAGAAAGIVAGPFGLIISYSIAAGVIEGKLIPELNNRLKTVQNFFTSLSATVKQANKDIDAAKLKLATEIAAIGEIKTETETTRFYVDYDDLMLSLLKGAAKKMINTCNEYQQRHGKKTLFEVPDV
InterPro domains: - IPR027018: Hemolysin E (family) [4-293]
Interaction partners: - Cytolethal distending toxin subunit B homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0001906 (cell killing), GO:0035821 (modulation of process of another organism), GO:0031640 (killing of cells of another organism), GO:0019835 (cytolysis), GO:0044403 (biological process involved in symbiotic interaction), GO:0050794 (regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031341 (regulation of cell killing), GO:0051709 (regulation of killing of cells of another organism), GO:0051715 (cytolysis in another organism), GO:0010941 (regulation of cell death), GO:0044179 (hemolysis in another organism), GO:0043067 (regulation of programmed cell death), GO:0001907 (killing by symbiont of host cells), GO:0001897 (cytolysis by symbiont of host cells), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (A4QNV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MEGENTLITENTSLYMNISAGLNASSSVSLSVSEYSDAEVVLISILIGILVLVIVFGNALVISAIVRFQRLQTVTNYFISSLACADLVMGLMVVPFGACYILLNTWHFGNFFCEFWTATDVLCVTASIETLCVIALDRYIAIMWPLRYQSMLTKRKACGMVIGVWAVAALISFLPIHMEWWVSDEPEALSCLEEPTCCDFNTNAAYAVTSSIISFYIPLVIMAFVYSRVFQEARRQLQKIDRIEGRIRTQSLSTQEGNEIKNRRTKFCIKDHKALKTLGIIMGTFTLCWLPFFVLNVVAAIWKMDNIMLPFRILNWIGYANSAFNPLIYCRSPEFRCAFQEILCWRPSHLRSTRSKKGYLYSGHSWKVHTKTTRPREPSPACETEIGAECLTAGTKNKNGNYNKTVTSI
InterPro domains: - IPR002233: Adrenoceptor family (family) [95-343]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [57-329]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [42-343]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0004935 (adrenergic receptor activity), GO:0004936 (alpha-adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0043473 (pigmentation), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0051239 (regulation of multicellular organismal process), GO:0044057 (regulation of system process), GO:0002027 (regulation of heart rate), GO:1903522 (regulation of blood circulation), GO:0008016 (regulation of heart contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Inner membrane protein YqjA (P0AA63)
Organism: Escherichia coli (strain K12)
Function: May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Sequence: MELLTQLLQALWAQDFETLANPSMIGMLYFVLFVILFLENGLLPAAFLPGDSLLVLVGVLIAKGAMGYPQTILLLTVAASLGCWVSYIQGRWLGNTRTVQNWLSHLPAHYHQRAHHLFHKHGLSALLIGRFIAFVRTLLPTIAGLSGLNNARFQFFNWMSGLLWVLILTTLGYMLGKTPVFLKYEDQLMSCLMLLPVVLLVFGLAGSLVVLWKKKYGNRG
InterPro domains: - IPR032816: VTT domain (domain) [48-174]
- IPR032818: DedA-like (family) [12-215]
Interaction partners: - Modulator protein MzrA
- TVP38/TMEM64 family inner membrane protein YdjZ
- TVP38/TMEM64 family membrane protein YdjX
- Inner membrane protein YqaA
- Inner membrane protein YebE
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Large ribosomal subunit protein eL22 (60S ribosomal protein L22) (Q32Q51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MAPIKKQVTKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVSIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANTKESYELRYFQINQDEEEEDED
InterPro domains: - IPR002671: Large ribosomal subunit protein eL22 (family) [5-125]
- IPR038526: Large ribosomal subunit protein eL22 superfamily (homologous_superfamily) [8-127]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) (Cyclophilin) (Cyclosporin A-binding protein) (Rotamase) (P21569)
Organism: Zea mays (Maize)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm.
Sequence: MANPRVFFDMTVGGAPAGRIVMELYANEVPKTAENFRALCTGEKGVGKSGKPLHYKGSTFHRVIPEFMCQGGDFTRGNGTGGESIYGEKFPDEKFVRKQPAPGVLSMANAGPNTNGSQFFICTVATPWLDGKHVVFGQVVEGMDVVKAIEKVGTRNGSTSKVVKVADCGQLS
InterPro domains: - IPR024936: Cyclophilin-type peptidyl-prolyl cis-trans isomerase (family) [1-172]
- IPR002130: Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain (domain) [7-170]
- IPR020892: Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (conserved_site) [55-72]
- IPR029000: Cyclophilin-like domain superfamily (homologous_superfamily) [1-172]
Interaction partners: - UPF0235 protein
- Elongation factor 1-alpha
- Nuclear pore complex protein NUP107
- Nuclear pore complex protein NUP88
- Cytochrome P450 monooxygenase
- Seh1-like protein
- Zinc finger CCCH domain-containing protein 4
- Elongation factor 1-alpha
- Elongation factor 1-alpha
- Elongation factor 1-alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0033218 (amide binding), GO:0140096 (catalytic activity, acting on a protein), GO:0042277 (peptide binding), GO:0016859 (cis-trans isomerase activity), GO:0003755 (peptidyl-prolyl cis-trans isomerase activity), GO:0016018 (cyclosporin A binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cystatin-SA (Cystatin-2) (Cystatin-S5) (P09228)
Organism: Homo sapiens (Human)
Function: Thiol protease inhibitor.
Subcellular location: Secreted {ECO:0000269|PubMed:20189825}.
Sequence: MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFQIYEVPWEDRMSLVNSRCQEA
InterPro domains: - IPR046350: Cystatin superfamily (homologous_superfamily) [32-139]
- IPR000010: Cystatin domain (domain) [29-139]
- IPR018073: Proteinase inhibitor I25, cystatin, conserved site (conserved_site) [75-88]
Interaction partners: - Cystatin-SN
- Serine/threonine-protein phosphatase CPPED1
- Cystatin-S
- Cystatin-B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0051606 (detection of stimulus), GO:0042221 (response to chemical), GO:0048871 (multicellular organismal-level homeostasis), GO:0019222 (regulation of metabolic process), GO:0003008 (system process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0050877 (nervous system process), GO:0009593 (detection of chemical stimulus), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0050906 (detection of stimulus involved in sensory perception), GO:0060249 (anatomical structure homeostasis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050907 (detection of chemical stimulus involved in sensory perception), GO:0001895 (retina homeostasis), GO:0051246 (regulation of protein metabolic process), GO:0007600 (sensory perception), GO:0051248 (negative regulation of protein metabolic process), GO:0045861 (negative regulation of proteolysis), GO:0050912 (detection of chemical stimulus involved in sensory perception of taste), GO:0007606 (sensory perception of chemical stimulus), GO:0030162 (regulation of proteolysis), GO:0050909 (sensory perception of taste), GO:0001580 (detection of chemical stimulus involved in sensory perception of bitter taste), GO:0050913 (sensory perception of bitter taste)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: VWFA domain-containing protein (Q57X62)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MNCEHVAYTTCASNGCGVLTANTFTPLTLVACSVEVEVHGNSARLNVRYEYNNYTGKDQRVIAAYPLPMWWDLMSCRADYAKDSVVGVHCVTIPLNVEVSDAAATSFPILPGPKPDGVVAIVAAQRLPWMIGLGSSVLIGATYAVPLNALCKAGEFRMVLPMELFPDAPPPPPSTMEYESLFAMKWPSKLPKGLTIDVKCKTFTPLAGTVELRPTGGNVCDPVPAQVEIVGDSGFRLHYEGPLAARVRGGFELFCPLFRTIEPLRFFVEVDNGREVCDDDRYALTLVLTPVVAEQLSATVNAELIFVVDSHSNYASACMSQALRVALYGAPDKAPVNIILITEENDICLCPGGSTQVNQLDIDGLAAFVAQTRPQRPSVGVSHLNRVMRSLVNSESTGPCGPVPRGFVRHIIVLSDEGTKSHAVEAISLAAHHQHNMRFSAVGLITAGGANAAALQLLAQEGGGVYYDATDAEELQAVLAQVVSLVAVPTVTDVELRFREPEVRVESKQLRAIPQGLQQFVQCFVPASLENFHVVVIGRIGSASVEYTGQGSLTEVFLTACSEPQNAFSVGMLHLSAAASRIRYLVEGRSSFTLNKSEVQEVGRYSETYMLPSPFTEMKQIRPSVGGGARSQTIPGAADTPIVAAARYVPRHWLYAQFLQRLSCRRLAEGLIDCRPQQLRQKIRQLEGATTNGDAPIVQQHSSASTLGKPRTTKEFIRHILMDIVDSVLATSLCVRRIAALQAPDGSFSLDSRLAVCVGLPCDRMKLDSLIVEDNAGEEHCEAQDVCKDKERLWATSLVVVSIEKQPSGIVTLAYRKAMSFIENNDPKGGFINRAREVFAGV
InterPro domains: - IPR002035: von Willebrand factor, type A (domain) [303-467]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [304-485]
Interaction partners: - poly
- Flap endonuclease 1
- KU80 protein
- DNA-repair protein, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0061061 (muscle structure development), GO:0080090 (regulation of primary metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0022008 (neurogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0030182 (neuron differentiation), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Peroxidase 71 (Atperox P71) (EC 1.11.1.7) (ATP15a) (ATPO2) (Q43387)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Subcellular location: Secreted {ECO:0000255|PROSITE-ProRule:PRU00297}.
Sequence: MGLVRSLCLLITFLNCLIISVHGQATARPGPVSGTRIGFYLTTCPRAETIVRNAVNAGFSSDPRIAPGILRMHFHDCFVQGCDGSILISGANTERTAGPNLNLQGFEVIDNAKTQLEAACPGVVSCADILALAARDTVILTQGTGWQVPTGRRDGRVSLASNANNLPGPRDSVAVQQQKFSALGLNTRDLVVLVGGHTIGTAGCGVFRNRLFNTTGQTADPTIDPTFLAQLQTQCPQNGDGSVRVDLDTGSGSTWDTSYYNNLSRGRGVLQSDQVLWTDPATRPIVQQLMAPRSTFNVEFARSMVRMSNIGVVTGANGEIRRVCSAVN
InterPro domains: - IPR010255: Haem peroxidase superfamily (homologous_superfamily) [36-328]
- IPR019794: Peroxidase, active site (active_site) [66-77]
- IPR019793: Peroxidases heam-ligand binding site (binding_site) [189-199]
- IPR002016: Haem peroxidase (domain) [34-328]
- IPR033905: Secretory peroxidase (domain) [36-327]
- IPR000823: Plant peroxidase (family) [18-321]
Interaction partners: - Berberine bridge enzyme-like 10
- UDP-glycosyltransferase 72E2
- UDP-glycosyltransferase 72E1
- Berberine bridge enzyme-like 11
- Cinnamyl alcohol dehydrogenase 4
- Cinnamyl alcohol dehydrogenase 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004601 (peroxidase activity), GO:0016491 (oxidoreductase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006970 (response to osmotic stress), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0009269 (response to desiccation), GO:0009651 (response to salt stress), GO:0006972 (hyperosmotic response), GO:0042538 (hyperosmotic salinity response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009505 (plant-type cell wall)
Protein: RIC3 acetylcholine receptor chaperone, isoform V (A0A0B4LH23)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Sequence: MPATATSKPRAPLVEEGMTPKKTALIIVTVIGCIAILWPKVFHPMMFGGVPPSQPNFKDPRAAPGGCCDVVLDREQFLNATKKDTVEPFGPHLYRKQINVYTGEISLRQERPAHLHPESIYQAMRERGRAIPATPTVPILERKTSPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSSMGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAPPNPAFRQEVFGSQNHSQVEDLGGSKLGAATATAAAKKPAAKDTEKELYNASVSATEVASSLSASLKSHQQLKEAEQLMEIEKLRQKLESTERAMAQLVAEMNTDQYEAKLLRPYKV
InterPro domains: - IPR032763: Resistance to inhibitors of cholinesterase protein 3, N-terminal (domain) [30-318]
- IPR026160: Resistance to inhibitors of cholinesterase protein 3 (family) [15-323]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0051082 (unfolded protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006457 (protein folding), GO:0022417 (protein maturation by protein folding), GO:1901564 (organonitrogen compound metabolic process), GO:0061077 (chaperone-mediated protein folding), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051604 (protein maturation), GO:0010467 (gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140534 (endoplasmic reticulum protein-containing complex), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit) (Q9CR61)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Peripheral membrane protein {ECO:0000269|PubMed:38575788}. Mitochondrion intermembrane space {ECO:0000269|PubMed:38575788}.
Sequence: MGAHLTRRYLWDASVEPDPEKIPSFPPDLGFPERKERVMVATQQEMMDAQLTLQQRDYCAHYLIRLLKCKRDSFPNFLACKHEQHDWDYCEHLDYVKRMKEFERERRLLQRKKRRALKEARVAQGQGEGEVGPEVAL
InterPro domains: - IPR008698: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7 (family) [1-120]
Interaction partners: - NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 3
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 9
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase iron-sulfur protein 6, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)