Protein: Choline/ethanolamine transporter FLVCR1 (Q7K1D7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MDLKHSAGGAGENSETFIATSKSTDMITPKEKEGKGLKVAGGHNPPAEGYKVYARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIGQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSPDLETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLESSEAEQVSFMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYALSMVGMWIFTFTLDTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTFGICFTLFYSELFTTFGDIAANITMAVMLIVGTIITAITQSDLRRQNAQVPASGQAGNP
InterPro domains: - IPR049680: Choline/ethanolamine transporter FLVCR1-2/SLC49-like (family) [45-472]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [45-469]
- IPR011701: Major facilitator superfamily (family) [63-428]
- IPR020846: Major facilitator superfamily domain (domain) [54-467]
Interaction partners: - Uncharacterized protein, isoform B
- Uncharacterized protein, isoform B
- Cytosolic Fe-S cluster assembly factor Nubp2 homolog
- Transferrin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046415 (urate metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0072521 (purine-containing compound metabolic process), GO:0051180 (vitamin transport), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0072337 (modified amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0009150 (purine ribonucleotide metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)