Protein: Pseudouridine synthase 1 (G8JLB3)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAGNAEPPPAGAACPQDRRSCSGRAGGDRVWEDGEHPAKKLKSGGDEERREKPPKRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDKGVSAAGQVVSLKVWLIDDILEKINSHLPSHIRILGLKRVTGGFNSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPQDPSACRYILEMYCEEPFVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESVLERSWGTEKVDVPKAPGLGLVLERVHFEKYNQRFGNDGLHEPLDWAQEEGKVAAFKEEHIYPTIIGTERDERSMAQWLSTLPIHNFSATALTAGGTGAK
InterPro domains: - IPR001406: Pseudouridine synthase I, TruA (family) [42-366]
- IPR020094: Pseudouridine synthase TruA/RsuA/RluB/E/F, N-terminal (homologous_superfamily) [46-168]
- IPR020103: Pseudouridine synthase, catalytic domain superfamily (homologous_superfamily) [54-327]
- IPR041708: Pseudouridine synthase PUS1/ PUS2-like (family) [60-312]
- IPR020097: Pseudouridine synthase I, TruA, alpha/beta domain (domain) [211-313]
- IPR020095: Pseudouridine synthase I, TruA, C-terminal (homologous_superfamily) [169-380]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0016866 (intramolecular transferase activity), GO:0003723 (RNA binding), GO:0009982 (pseudouridine synthase activity), GO:0003727 (single-stranded RNA binding), GO:0000049 (tRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0140053 (mitochondrial gene expression), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:1900864 (mitochondrial RNA modification), GO:0000963 (mitochondrial RNA processing), GO:0016071 (mRNA metabolic process), GO:0034470 (ncRNA processing), GO:0000959 (mitochondrial RNA metabolic process), GO:0016556 (mRNA modification), GO:0006400 (tRNA modification), GO:0001522 (pseudouridine synthesis), GO:0070525 (tRNA threonylcarbamoyladenosine metabolic process), GO:0034660 (ncRNA metabolic process), GO:0090646 (mitochondrial tRNA processing), GO:0031119 (tRNA pseudouridine synthesis), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)