Protein: Cd68 molecule (Q4FZY1)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004352, ECO:0000256|PROSITE-ProRule:PRU00740}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004352, ECO:0000256|PROSITE-ProRule:PRU00740}.
Sequence: MRFPVCLTLLVLLVAQGTGKDCPHKKAATLLPSFTETPTTTGSTASPTTTHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHGNATVSPTTNSPGFSTVGPHPGPPPPSPSPSPSSTGALGNYTWTNGSQPCVQLQAQIQIRILYLTQGGKKAWGLSVLNPNKTKVQGGCDSAHPHLALSFPYGQLTFGFKQDRHQSHSTVYLNYMAVEYNVSFPQAAQWTFSAQNSSLQELQAPLGQSFCCGNTSIVLSPAIHLDLLSLRLQAAQLPDKGHFGPCFSCASDQSLLLPLIIGLVLLGLLTLVLIAFCVTRRRQSTYQPL
InterPro domains: - IPR018134: Lysosome-associated membrane glycoprotein, conserved site (conserved_site) [290-328]
- IPR048528: Lysosome-associated membrane glycoprotein 2-like, luminal domains (domain) [131-278]
- IPR002000: Lysosome-associated membrane glycoprotein (family) [15-330]
Interaction partners: - Scavenger receptor cysteine-rich type 1 protein M130
- Allograft inflammatory factor 1
- T-cell surface glycoprotein CD4
- Glial fibrillary acidic protein
- Integrin alpha-D
- Interleukin-1 beta
- CX3C chemokine receptor 1
- Receptor-type tyrosine-protein phosphatase C
- Interleukin-6
- Tumor necrosis factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0007568 (aging), GO:0051707 (response to other organism), GO:0009991 (response to extracellular stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0007584 (response to nutrient), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:0032101 (regulation of response to external stimulus), GO:1901700 (response to oxygen-containing compound), GO:0031349 (positive regulation of defense response), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0010243 (response to organonitrogen compound), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0002237 (response to molecule of bacterial origin), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0071222 (cellular response to lipopolysaccharide), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)