Protein: TAR DNA-binding protein 43 (Q802C7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MAEMYIRVAEEENEEPMEIPSEDDGTVLLSTVSAQFPGACGLRFRSPVSQCMRGVRLVDGILHAPENGWGNLVYVVNYPKETVLPDNKRKMDEIDASSATKIKRGDQKTSDLIVLGLPWKTSEQDLKDYFGTFGEVIMVQVKRDVKTGNSKGFGFVRFGDWETQSKVMTQRHMIDGRWCDCKLPNSKQGIDEPMRSRKVFVGRCTEDMTADELRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAAALCGEDLIIKGVSVHISNAEPKHNNTRQMMERAGRFGNGFGGQGFAGSRSNMGGGGGGSSSSLGNFGNFNLNPAMMAAAQAALQSSWGMMGMLAQQNQSGTSGTSTSGTSSSRDQAQTYSSANSNYGSSSAALGWGTGSNSGAASAGFNSSFGSSMESKSSGWGM
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [111-298]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [97-275]
- IPR049124: TAR DNA-binding protein 43, C-terminal (domain) [268-370]
- IPR041105: TAR DNA-binding protein 43, N-terminal (domain) [5-78]
- IPR000504: RNA recognition motif domain (domain) [110-268]
Interaction partners: - RNA-binding protein FUS
- Guanine nucleotide exchange C9orf72 homolog
- Ataxin-2
- SUMO-conjugating enzyme UBC9-B
- Superoxide dismutase
- Homeobox protein goosecoid
- Transitional endoplasmic reticulum ATPase
- VAMP-associated protein B and C
- Protein ref
- Senataxin.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0042752 (regulation of circadian rhythm), GO:0044237 (cellular metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:1901360 (organic cyclic compound metabolic process), GO:0032388 (positive regulation of intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060341 (regulation of cellular localization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051222 (positive regulation of protein transport), GO:0031647 (regulation of protein stability), GO:0043170 (macromolecule metabolic process), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0032386 (regulation of intracellular transport), GO:0090304 (nucleic acid metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0046824 (positive regulation of nucleocytoplasmic transport), GO:0032880 (regulation of protein localization), GO:1900182 (positive regulation of protein localization to nucleus), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0042307 (positive regulation of protein import into nucleus), GO:0033157 (regulation of intracellular protein transport), GO:1900180 (regulation of protein localization to nucleus), GO:0006396 (RNA processing), GO:0046822 (regulation of nucleocytoplasmic transport), GO:0008380 (RNA splicing), GO:0042306 (regulation of protein import into nucleus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)