Protein: Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) (P21327)
Organism: Bos taurus (Bovine)
Function: Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism.
Sequence: MSDILQELLRVSEKAANIARACRQQETLFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEVIKENMENKFPGLGKKIFGEESNEFTNDLGEKIIMRLGPTEEETVALLSKVLNGNKLASEALAKVVHQDVFFSDPALDSVEINIPQDILGIWVDPIDSTYQYIKGSADITPNQGIFPSGLQCVTVLIGVYDIQTGVPLMGVINQPFVSQDLHTRRWKGQCYWGLSYLGTNIHSLLPPVSTRSNSEAQSQGTQNPSSEGSCRFSVVISTSEKETIKGALSHVCGERIFRAAGAGYKSLCVILGLADIYIFSEDTTFKWDSCAAHAILRAMGGGMVDLKECLERNPDTGLDLPQLVYHVGNEGAAGVDQWANKGGLIAYRSEKQLETFLSRLLQHLAPVATHT
InterPro domains: - IPR050725: CysQ/Inositol Monophosphatase (family) [2-390]
- IPR020550: Inositol monophosphatase, conserved site (conserved_site) [316-330]
- IPR020583: Inositol monophosphatase, metal-binding site (binding_site) [151-163]
- IPR000760: Inositol monophosphatase-like (family) [72-380]
- IPR044897: Inositol polyphosphate 1-phosphatase, domain 1 (homologous_superfamily) [81-127]
Interaction partners: - Inositol monophosphatase 1
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- Inositol monophosphatase 2
- Inositol-tetrakisphosphate 1-kinase
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
- Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
- INPP5K protein
- Inositol polyphosphate-5-phosphatase A.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0008252 (nucleotidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0043647 (inositol phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:0046434 (organophosphate catabolic process), GO:0019751 (polyol metabolic process), GO:0046838 (phosphorylated carbohydrate dephosphorylation), GO:0016311 (dephosphorylation), GO:0046174 (polyol catabolic process), GO:0071545 (inositol phosphate catabolic process), GO:0046855 (inositol phosphate dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)