wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Protein disulfide-isomerase A4 (P08003)
Organism: Mus musculus (Mouse)
Subcellular location: Endoplasmic reticulum lumen. Melanosome
Sequence: MKLRKAWLLVLLLALTQLLAAASAGDAHEDTSDTENATEEEEEEDDDDLEVKEENGVWVLNDGNFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKILKKGQAVDYDGSRTQEEIVAKVREVSQPDWTPPPEVTLSLTKDNFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVVIIGLFQGDGDPAYLQYQDAANNLREDYKFHHTFSPEIAKFLKVSLGKLVLTHPEKFQSKYEPRFHVMDVQGSTEASAIKDYVVKHALPLVGHRKTSNDAKRYSKRPLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDFPEYTFAIADEEDYATEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHATKRSRTKEEL
InterPro domains: - IPR013766: Thioredoxin domain (domain) [16-629]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [52-629]
- IPR017068: Protein disulphide-isomerase A4 (family) [1-638]
- IPR041866: Protein disulfide-isomerase A4, TRX-like domain b (domain) [279-385]
- IPR005792: Protein disulphide isomerase (family) [172-635]
- IPR005788: Protein disulfide-isomerase, thioredoxin-like domain (domain) [60-627]
- IPR017937: Thioredoxin, conserved site (conserved_site) [76-558]
Interaction partners: - Endoplasmin
- Hypoxia up-regulated protein 1
- Endoplasmic reticulum chaperone BiP
- Peptidyl-prolyl cis-trans isomerase B
- DnaJ homolog subfamily B member 11
- ERO1-like protein beta
- Stromal cell-derived factor 2-like protein 1
- ERO1-like protein alpha
- Protein disulfide-isomerase A6
- Calreticulin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016860 (intramolecular oxidoreductase activity), GO:0003756 (protein disulfide isomerase activity), GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0006457 (protein folding), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0061077 (chaperone-mediated protein folding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140534 (endoplasmic reticulum protein-containing complex), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: PE-PGRS family protein PE25 (I6X486)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response. The dimer induces necrosis, but not apoptosis, in mouse macrophage cells. It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses
Subcellular location: Secreted. Note=Secreted via the ESX-5 / type VII secretion system (T7SS)
Sequence: MSFVITNPEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTGADKYATAEADNIKTFS
InterPro domains: - IPR038332: PPE superfamily (homologous_superfamily) [8-84]
- IPR000084: PE-PGRS family, N-terminal (domain) [4-94]
Interaction partners: - PPE family protein PPE41
- ESX-5 secretion-associated protein EspG5
- Esterase PE16
- Triacylglycerol lipase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0009274 (peptidoglycan-based cell wall)
Protein: Ankyrin repeat protein OPG003 (Q76QY7)
Organism: Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Function: May be involved in virus-host protein interaction through the ankyrin repeats and PRANC regions
Sequence: MDEIVNIVRDSMWFIPNVFMDNGENDGHVSVNNVCHMYFAFFDVDTSSHLFKLVIKHCDLNKQLKCGMSPLHCYVMNTRFKPSVLKILLHNGVNNFDNKDNKGHIPLHHYLIYSLSIDNKVFDILTDPIDDFSKSSDLLLCYLRYKFNGRLNYYVLYKLLTKGSDPNCVDEDGLTSLHYYCKHISAFHESNYYKSKSYTKMRAEKRFIYTIINHGANINAVTKIGNTPLHTYLQQYTKHSPRVVYALLSRGADTRIRNNFDCTPIMEYIKNDCVTGHILIMLLNWHEQKYGKLQKEEGHHLLYLFIKHNQGYGSHAFNILRYLLDRFDIQKDEYYNTMTPLHTAFQNCNNNVASYLVYIGYDINLPTKDDKTVFDLVFENRNILFNAGVIHNIIHHRLKVSLPMIKSLFYKMLEFSPYDDYYVKKIIAYCILRDESFTELHSKFCLNEDYKSVFMKNISFDKIDSIIKKCNWDISRLKDIQISDTNLYTVLRTEDIRYRTYLKAIHLDSHISFPMYDDLIEQCHLSMERKSKLVDKVLNKLKSTIDGQSRLSYLPPEIIRNIITKLSDYHLNSMLYGKNHYKYYT
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [48-395]
- IPR018272: PRANC domain (domain) [483-575]
- IPR002110: Ankyrin repeat (repeat) [66-368]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0048523 (negative regulation of cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0050794 (regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031341 (regulation of cell killing), GO:0051709 (regulation of killing of cells of another organism), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0019054 (modulation by virus of host cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0044003 (modulation by symbiont of host process), GO:0039526 (modulation by virus of host apoptotic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0052041 (suppression by symbiont of host programmed cell death), GO:0052150 (modulation by symbiont of host apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0019050 (suppression by virus of host apoptotic process), GO:0033668 (suppression by symbiont of host apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Early protein OPG038 (Q80HY2)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Plays a role in immune evasion. When secreted, inhibits T- cell activation by preventing the binding of host CD80 and CD86 to soluble CTLA4 and CD28. In the infected cell, may inhibits host NF kappa B activation
Subcellular location: Host endoplasmic reticulum. Secreted
Sequence: MVYKLVLLFCIASLGYSVEYKNTICPPRQDYRYWYFAAELTIGVNYDINSTIIGECHMSESYIDRNANIVLTGYGLEINMTIMDTDQRFVAAAEGVGKDNKLSVLLFTTQRLDKVHHNISVTITCMEMNCGTTKYDSDLPESIHKSSSCDITINGSCVTCVNLETDPTKINPHYLHPKDKYLYHNSEYSMRGSYGVTFIDELNQCLLDIKELSYDICYRE
InterPro domains: - IPR006971: Poxvirus M2 (family) [1-220]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0075528 (modulation by virus of host immune response), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0019049 (mitigation of host antiviral defense response), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0005576 (extracellular region), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part), GO:0044164 (host cell cytosol)
Protein: Protein K3 (P18378)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Viral mimic of EIF2S1/eIF-2alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore EIF2S1/eIF-2alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Determinant of host species specificity
Sequence: MLAFCYSLPNAGDVIKGRVYEKDYALYIYLFDYPHFEAILAESVKMHMDRYVEYRDKLVGKTVKVKVIRVDYTKGYIDVNYKRMCRHQ
InterPro domains: - IPR003029: S1 domain (domain) [9-82]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [1-88]
- IPR016397: Protein K3-like, poxvirus (family) [1-88]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm)
Protein: Protein OPG176 (P26672)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Acts close to the plasma membrane and targets several host TIR-domain containing adapter proteins including MYD88, TIRAP, TRIF and TICAM2. In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation
Sequence: MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALAEHISDSIPISELSRLRYNLCKYLRGHTESIEDKFDYFEDDDSSTCSAVTDRETDV
InterPro domains: - IPR043018: Poxvirus domain superfamily (homologous_superfamily) [79-224]
- IPR022819: Poxvirus Bcl-2-like (family) [22-182]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0039693 (viral DNA genome replication), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019028 (viral capsid)
Protein: Soluble interferon gamma receptor OPG193 (P24770)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Counteracts the antiviral effects of host IFN-gamma. Acts as a soluble IFN-gamma receptor and thus inhibits the interaction between host IFN-gamma and its receptor
Subcellular location: Secreted
Sequence: MRYIIILAVLFINSIHAKITSYKFESVNFDSKIEWTGDGLYNISLKNYGIKTWQTMYTNVPEGTYDISAFPKNDFVSFWVKFEQGDYKVEEYCTGLCVEVKIGPPTVTLTEYDDHINLYIEHPYATRGSKKIPIYKRGDMCDIYLLYTANFTFGDSKEPVPYDIDDYDCTSTGCSIDFVTTEKVCVTAQGATEGFLEKITPWSSKVCLTPKKSVYTCAIRSKEDVPNFKDKMARVIKRKFNKQSQSYLTKFLGSTSNDVTTFLSMLNLTKYS
InterPro domains: - IPR013783: Immunoglobulin-like fold (homologous_superfamily) [18-211]
- IPR054752: Interferon-gamma receptor, N-terminal domain (domain) [19-98]
- IPR021126: Interferon gamma receptor, D2 domain, poxvirus/mammal (domain) [107-209]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [23-211]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048583 (regulation of response to stimulus), GO:1900047 (negative regulation of hemostasis), GO:0065008 (regulation of biological quality), GO:0051241 (negative regulation of multicellular organismal process), GO:0035821 (modulation of process of another organism), GO:0051239 (regulation of multicellular organismal process), GO:1900046 (regulation of hemostasis), GO:0048585 (negative regulation of response to stimulus), GO:0050818 (regulation of coagulation), GO:0030195 (negative regulation of blood coagulation), GO:0032101 (regulation of response to external stimulus), GO:0030193 (regulation of blood coagulation), GO:0050878 (regulation of body fluid levels), GO:0050819 (negative regulation of coagulation), GO:1903035 (negative regulation of response to wounding), GO:0080134 (regulation of response to stress), GO:0032102 (negative regulation of response to external stimulus), GO:0061045 (negative regulation of wound healing), GO:1903034 (regulation of response to wounding), GO:0061041 (regulation of wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Protein OPG200 (P24772)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B. Mechanistically, sterically hinders the direct contact between the kinase domains of IKBKB in the IKK complex containing IKBKB, CHUK/IKKA and NEMO
Sequence: MTANFSTHVFSPQHCGCDRLTSIDDVRQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAELVFIDIRELVKNMPWDDVKDCAEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLEMLNYVDYNIIFRRMN
InterPro domains: - IPR043018: Poxvirus domain superfamily (homologous_superfamily) [16-149]
- IPR022819: Poxvirus Bcl-2-like (family) [2-142]
- IPR011212: Poxvirus, Protein B14/B22/C16 (family) [1-149]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019068 (virion assembly), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019028 (viral capsid)
Protein: Soluble interferon alpha/beta receptor OPG204 (P25213)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor
Subcellular location: Secreted. Note=Found associated with both uninfected and infected host cell membranes after secretion
Sequence: MTMKMMVHIYFVSLLLLLFHSYAIDIENEITEFFNKMRDTLPAKDSKWLNPACMFGGTMNDIAALGEPFSAKCPPIEDSLLSHRYKDYVVKWERLEKNRRRQVSNKRVKHGDLWIANYTSKFSNRRYLCTVTTKNGDCVQGIVRSHIRKPPSCIPKTYELGTHDKYGIDLYCGILYAKHYNNITWYKDNKEINIDDIKYSQTGKELIIHNPELEDSGRYDCYVHYDDVRIKNDIVVSRCKILTVIPSQDHRFKLILDPKINVTIGEPANITCTAVSTSLLIDDVLIEWENPSGWLIGFDFDVYSVLTSRGGITEATLYFENVTEEYIGNTYKCRGHNYYFEKTLTTTVVLE
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [150-348]
- IPR007110: Immunoglobulin-like domain (domain) [155-345]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [261-341]
- IPR015621: Interleukin-1 receptor family (family) [63-348]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [23-351]
- IPR003599: Immunoglobulin domain subtype (domain) [157-351]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0003006 (developmental process involved in reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0008406 (gonad development), GO:0061458 (reproductive system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Predicted GPI-anchored protein 26 (Q5AA09)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored protein involved in proper cell wall integrity. Does not seem to be directly involved in the synthesis of the cell wall. Required for normal virulence in a mouse model of disseminated candidiasis
Subcellular location: Cell membrane; Lipid-anchor, GPI- anchor
Sequence: MHFSKIIAGSALSSVALAEFQNGTVTTHVTATGYTTYCPYPTTITLTICEEENICTKRPIVVSEPTTVTVTEPCIISTSYETTEVVVTTTLPSSLSPSSVAPANVTSFEGAGSKNVASALVGVVAIAAAMM
Interaction partners: - Hyphally regulated cell wall protein 3
- Probable circularly permuted 1,3-beta-glucanase PGA52
- Cell wall protein IFF4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0009628 (response to abiotic stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0016043 (cellular component organization), GO:0009268 (response to pH), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0104004 (cellular response to environmental stimulus), GO:0071555 (cell wall organization), GO:0071214 (cellular response to abiotic stimulus), GO:0031505 (fungal-type cell wall organization), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0045229 (external encapsulating structure organization), GO:0036176 (response to neutral pH), GO:0071467 (cellular response to pH), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0036244 (cellular response to neutral pH)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)