Protein: Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (Melanoma nuclear protein 18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144) (P23798)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:2246278}.
Sequence: MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWRRNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMTVNGAPCPP
InterPro domains: - IPR032443: RAWUL domain (domain) [164-228]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1-108]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [34-43]
- IPR001841: Zinc finger, RING-type (domain) [18-57]
Interaction partners: - Chromobox protein homolog 2
- E3 ubiquitin-protein ligase RING1
- E3 ubiquitin-protein ligase RING2
- Polycomb complex protein BMI-1
- Polyhomeotic-like protein 1
- Chromobox protein homolog 8
- Chromobox protein homolog 7
- Polyhomeotic-like protein 2
- RING1 and YY1-binding protein
- Polycomb protein SCMH1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0055106 (ubiquitin-protein transferase regulator activity), GO:1990841 (promoter-specific chromatin binding), GO:0008047 (enzyme activator activity), GO:0097027 (ubiquitin-protein transferase activator activity), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0032259 (methylation), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0051301 (cell division), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0012501 (programmed cell death), GO:0060548 (negative regulation of cell death), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:0006725 (cellular aromatic compound metabolic process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0044260 (cellular macromolecule metabolic process), GO:0050865 (regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0043414 (macromolecule methylation), GO:0045785 (positive regulation of cell adhesion), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0050867 (positive regulation of cell activation), GO:0002696 (positive regulation of leukocyte activation), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0006139 (nucleobase-containing compound metabolic process), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0006959 (humoral immune response), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0017145 (stem cell division), GO:0048705 (skeletal system morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022409 (positive regulation of cell-cell adhesion), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0048103 (somatic stem cell division), GO:0022407 (regulation of cell-cell adhesion), GO:0070663 (regulation of leukocyte proliferation), GO:0010468 (regulation of gene expression), GO:0006306 (DNA methylation), GO:0007420 (brain development), GO:0043412 (macromolecule modification), GO:0048568 (embryonic organ development), GO:0051251 (positive regulation of lymphocyte activation), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0007417 (central nervous system development), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0070665 (positive regulation of leukocyte proliferation), GO:0051252 (regulation of RNA metabolic process), GO:0021532 (neural tube patterning), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0051249 (regulation of lymphocyte activation), GO:0021915 (neural tube development), GO:0048562 (embryonic organ morphogenesis), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:0036211 (protein modification process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006915 (apoptotic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0042981 (regulation of apoptotic process), GO:0050670 (regulation of lymphocyte proliferation), GO:0006304 (DNA modification), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:2001141 (regulation of RNA biosynthetic process), GO:0018193 (peptidyl-amino acid modification), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0050864 (regulation of B cell activation), GO:0050871 (positive regulation of B cell activation), GO:0043009 (chordate embryonic development), GO:0050870 (positive regulation of T cell activation), GO:0048704 (embryonic skeletal system morphogenesis), GO:0043066 (negative regulation of apoptotic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0006355 (regulation of DNA-templated transcription), GO:0043543 (protein acylation), GO:0048706 (embryonic skeletal system development), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0016570 (histone modification), GO:0021903 (rostrocaudal neural tube patterning), GO:0001701 (in utero embryonic development), GO:0030890 (positive regulation of B cell proliferation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0016573 (histone acetylation), GO:0030888 (regulation of B cell proliferation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032446 (protein modification by small protein conjugation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042102 (positive regulation of T cell proliferation), GO:0016574 (histone ubiquitination), GO:0006305 (DNA alkylation), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0042129 (regulation of T cell proliferation), GO:0006473 (protein acetylation), GO:0018205 (peptidyl-lysine modification), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0006475 (internal protein amino acid acetylation), GO:0016567 (protein ubiquitination), GO:0018394 (peptidyl-lysine acetylation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0140535 (intracellular protein-containing complex), GO:0000792 (heterochromatin), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)