Protein: Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) (Q9V3Q6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis.
Sequence: MATASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQYASRQLAAGHHPQPHPHPHPNQLQHPHSHPPMHFLQDEGCGLLPGSVCGGSESVEEGWVVIPPHHNA
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [13-274]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [136-148]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [19-264]
- IPR017441: Protein kinase, ATP binding site (binding_site) [25-46]
- IPR000719: Protein kinase domain (domain) [19-271]
Interaction partners: - LD40663p
- GH01161p
- Protein immune deficiency
- mitogen-activated protein kinase kinase
- NF-kappa-B essential modulator
- Dual specificity mitogen-activated protein kinase kinase hemipterous
- mitogen-activated protein kinase kinase
- Death-associated inhibitor of apoptosis 2
- Mitogen-activated protein kinase
- LD20892p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0004709 (MAP kinase kinase kinase activity), GO:0019901 (protein kinase binding), GO:0051019 (mitogen-activated protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048522 (positive regulation of cellular process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0045926 (negative regulation of growth), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0010942 (positive regulation of cell death), GO:0009968 (negative regulation of signal transduction), GO:0007552 (metamorphosis), GO:0048729 (tissue morphogenesis), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0001708 (cell fate specification), GO:0060255 (regulation of macromolecule metabolic process), GO:0007308 (oocyte construction), GO:0042078 (germ-line stem cell division), GO:0032970 (regulation of actin filament-based process), GO:0044087 (regulation of cellular component biogenesis), GO:0035295 (tube development), GO:0009894 (regulation of catabolic process), GO:0009887 (animal organ morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0009967 (positive regulation of signal transduction), GO:0007276 (gamete generation), GO:0048736 (appendage development), GO:0030707 (follicle cell of egg chamber development), GO:0007281 (germ cell development), GO:0010648 (negative regulation of cell communication), GO:0009798 (axis specification), GO:0001558 (regulation of cell growth), GO:0090132 (epithelium migration), GO:0035107 (appendage morphogenesis), GO:0051130 (positive regulation of cellular component organization), GO:0030307 (positive regulation of cell growth), GO:0031324 (negative regulation of cellular metabolic process), GO:0009880 (embryonic pattern specification), GO:2000147 (positive regulation of cell motility), GO:0045165 (cell fate commitment), GO:2000026 (regulation of multicellular organismal development), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0048640 (negative regulation of developmental growth), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051964 (negative regulation of synapse assembly), GO:0032535 (regulation of cellular component size), GO:0010631 (epithelial cell migration), GO:0043254 (regulation of protein-containing complex assembly), GO:0060562 (epithelial tube morphogenesis), GO:0043067 (regulation of programmed cell death), GO:0048880 (sensory system development), GO:0031330 (negative regulation of cellular catabolic process), GO:0000165 (MAPK cascade), GO:0048707 (instar larval or pupal morphogenesis), GO:0090596 (sensory organ morphogenesis), GO:0060251 (regulation of glial cell proliferation), GO:0032956 (regulation of actin cytoskeleton organization), GO:0002009 (morphogenesis of an epithelium), GO:0050769 (positive regulation of neurogenesis), GO:0016331 (morphogenesis of embryonic epithelium), GO:0007447 (imaginal disc pattern formation), GO:0048568 (embryonic organ development), GO:0010507 (negative regulation of autophagy), GO:0007399 (nervous system development), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0048737 (imaginal disc-derived appendage development), GO:0031330 (negative regulation of cellular catabolic process), GO:0000165 (MAPK cascade), GO:0030335 (positive regulation of cell migration), GO:0009953 (dorsal/ventral pattern formation), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0048858 (cell projection morphogenesis), GO:0043491 (protein kinase B signaling), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0048663 (neuron fate commitment), GO:0035120 (post-embryonic appendage morphogenesis), GO:0060284 (regulation of cell development), GO:0007423 (sensory organ development), GO:0048477 (oogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:1902532 (negative regulation of intracellular signal transduction), GO:0051960 (regulation of nervous system development), GO:1901889 (negative regulation of cell junction assembly), GO:0001667 (ameboidal-type cell migration), GO:0030855 (epithelial cell differentiation), GO:0036211 (protein modification process), GO:0010639 (negative regulation of organelle organization), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0048569 (post-embryonic animal organ development), GO:0010634 (positive regulation of epithelial cell migration), GO:0033043 (regulation of organelle organization), GO:0060429 (epithelium development), GO:0031329 (regulation of cellular catabolic process), GO:0010638 (positive regulation of organelle organization), GO:1902531 (regulation of intracellular signal transduction), GO:0009952 (anterior/posterior pattern specification), GO:0060541 (respiratory system development), GO:0051493 (regulation of cytoskeleton organization), GO:0048592 (eye morphogenesis), GO:0046552 (photoreceptor cell fate commitment), GO:0007472 (wing disc morphogenesis), GO:0150063 (visual system development), GO:0007424 (open tracheal system development), GO:0016310 (phosphorylation), GO:0007427 (epithelial cell migration, open tracheal system), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0007391 (dorsal closure), GO:0035330 (regulation of hippo signaling), GO:0016333 (morphogenesis of follicular epithelium), GO:0035330 (regulation of hippo signaling), GO:0016333 (morphogenesis of follicular epithelium), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0001654 (eye development), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0046530 (photoreceptor cell differentiation), GO:0008361 (regulation of cell size), GO:0035220 (wing disc development), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0035218 (leg disc development), GO:0001738 (morphogenesis of a polarized epithelium), GO:0009913 (epidermal cell differentiation), GO:0035332 (positive regulation of hippo signaling), GO:0060446 (branching involved in open tracheal system development), GO:0046578 (regulation of Ras protein signal transduction), GO:0045793 (positive regulation of cell size), GO:0038127 (ERBB signaling pathway), GO:0008293 (torso signaling pathway), GO:1904263 (positive regulation of TORC1 signaling), GO:0042706 (eye photoreceptor cell fate commitment), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0008543 (fibroblast growth factor receptor signaling pathway), GO:0048749 (compound eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)