Protein: Putative exoribonuclease DIS3 (Q9BI20)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MQTLREFTRKTKRGNILKIVREHYLRDDIGCGSELCRECFQNEVYQLTSQHANKSTLFKFPHYLVLDTNVVLDQIDVLEEDVLRNVVVLTTVLNEVKHRSSAIYKRFNEIVHDRTRNFYVFVNEHHKETYADREPDETANDRNDRAIRLATKWYDDHLQASQSSKEFERSGKAATRVVLLTDDAANRAKAEAEGILVTTAAEYVKSLEDFPLLMDKLSHKTFDSEKNGLPQYPPHLSMKELLEGLRQNKLLQGTFQASRENYLEGTVNVEKFEKGILIQGRESLNRAVDGDLVAVELLPEAEWSAPSEIVLEEKNVYADEVPSEERAKDENEMLNQVRAAALSAERTPTGRIVGIVRRKWRQYCGILQPSLIEDTNRHIFVPADRKIPRIRIETRQAAMLQNQRIIVTIDTWPRNSRYPHGHFVRSLGPLGDMATENEVILLEHDVPHCKFSDEVLSFLPKMPWTITDEDYSKRVDLRDLYICSVDPPGCTDIDDALHCRELPNGNLEVGVHIADVSHFIRPGKRTGHGGSGPGETTVYLVGKRIDMVPELLSSNLCSLVGGVERFAFSCVWEVDNEANVLSKRFHKSVIKSKRAMTYEEAQNIIDDATQQNEIAKSLRNLNRLAKILKKRRMDNGALVLASPEIRFQVDSETHEPLEVEVKQMRETNSMVEEFMLLANITVAEHIATEFSECAVLRRHPRPPPTNFDPLVKSARYQGFQVDINSGLELSHSLDKCVKADNPYFNTMIRILTTRCMMQAVYFISGSLQKEEFFHYGLAAPIYTHFTSPIRRYSDIMVHRLLAASIGADSTYAQLLDRKSNEELCHNLNYRHKMAQYAGRASVALNTHLFFRGKEEDEEGYVLFVRKNALQVLIPKYGLEGTLYLKSDKDGKDGVERVKSEIVFTFNEEDHTQRCGDVVFHSFDPVTVRLSLDSSNVQHEKLIFRLVKPYIKGFSVETTTEGTDSQAVSAAPPSKKTKKDKKKK
InterPro domains: - IPR041505: Dis3-like cold-shock domain 2 (domain) [379-445]
- IPR033770: Exosome complex exonuclease RRP44, S1 domain (domain) [856-935]
- IPR002716: PIN domain (domain) [62-198]
- IPR029060: PIN-like domain superfamily (homologous_superfamily) [61-209]
- IPR022966: Ribonuclease II/R, conserved site (conserved_site) [774-798]
- IPR050180: RNR Ribonuclease (family) [21-949]
- IPR001900: Ribonuclease II/R (domain) [474-807]
- IPR033771: Rrp44-like cold shock domain (domain) [232-332]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [231-945]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004532 (exoribonuclease activity), GO:0004521 (RNA endonuclease activity), GO:0004527 (exonuclease activity), GO:0004519 (endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0009615 (response to virus), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0098542 (defense response to other organism), GO:0034655 (nucleobase-containing compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0140546 (defense response to symbiont), GO:0090304 (nucleic acid metabolic process), GO:0051607 (defense response to virus), GO:0044265 (cellular macromolecule catabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0006401 (RNA catabolic process), GO:0071025 (RNA surveillance), GO:0071027 (nuclear RNA surveillance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005652 (nuclear lamina), GO:1902494 (catalytic complex), GO:0034399 (nuclear periphery), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0000176 (nuclear exosome (RNase complex)), GO:0000178 (exosome (RNase complex)), GO:1905354 (exoribonuclease complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)