Protein: All trans-polyprenyl-diphosphate synthase PDSS1 (All-trans-decaprenyl-diphosphate synthase subunit 1) (EC 2.5.1.91) (Decaprenyl-diphosphate synthase subunit 1) (Solanesyl-diphosphate synthase subunit 1) (Trans-prenyltransferase 1) (TPT 1) (Q33DR2)
Organism: Mus musculus (Mouse)
Function: Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:Q5T2R2}.
Sequence: MAMRWSCWRRGCSWRPTAVGSPRRERPGCVEPLGTRAASDTRAQIPYFSLMKILMSASPTMHSISQFHQRTPAMCSCRQTQSGEKYSDPFKLGWRDLKGLYEDIRKELHISTRELKDMSEYYFDGKGKAFRPIIVVLMARACNIHHNNAREMQASQRSIALVAEMIHTATLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASVALARIGNTAVVSMLAQVIEDLVRGEFLQLGSKENENERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGIATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHKAVREIRKLRPSTERDALIQLSESVLTRDK
InterPro domains: - IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [82-409]
- IPR000092: Polyprenyl synthetase-like (family) [110-407]
- IPR033749: Polyprenyl synthetase, conserved site (conserved_site) [171-305]
Interaction partners: - 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS2
- Geranylgeranyl pyrophosphate synthase
- Protein farnesyltransferase subunit beta
- Dehydrodolichyl diphosphate synthase complex subunit Dhdds
- Farnesyl pyrophosphate synthase
- Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Dehydrodolichyl diphosphate synthase complex subunit Nus1
- Squalene synthase
- Ubiquinone biosynthesis protein COQ9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0046983 (protein dimerization activity), GO:0004659 (prenyltransferase activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0006082 (organic acid metabolic process), GO:0048731 (system development), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0022008 (neurogenesis), GO:0097305 (response to alcohol), GO:0006631 (fatty acid metabolic process), GO:0007399 (nervous system development), GO:0071310 (cellular response to organic substance), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0033993 (response to lipid), GO:0030855 (epithelial cell differentiation), GO:0060429 (epithelium development), GO:1901701 (cellular response to oxygen-containing compound), GO:0008610 (lipid biosynthetic process), GO:0030855 (epithelial cell differentiation), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0045446 (endothelial cell differentiation), GO:0042063 (gliogenesis), GO:0048699 (generation of neurons), GO:0097306 (cellular response to alcohol), GO:0046394 (carboxylic acid biosynthetic process), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0002067 (glandular epithelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)