Protein: Delta-like protein 3 (O88516)
Organism: Mus musculus (Mouse)
Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence: MVSLQVSPLSQTLILAFLLPQALPAGVFELQIHSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREDWLIQVLF
InterPro domains: - IPR000742: EGF-like domain (domain) [211-463]
- IPR050906: Notch signaling pathway (family) [175-369]
- IPR001881: EGF-like calcium-binding domain (domain) [277-463]
- IPR013032: EGF-like, conserved site (conserved_site) [398-457]
- IPR011651: Notch ligand, N-terminal domain (domain) [26-173]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [339-463]
Interaction partners: - Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 4
- Neurogenic locus notch homolog protein 3
- Delta-like protein 1
- Delta-like protein 4
- Recombining binding protein suppressor of hairless
- Transcription factor HES-5
- Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
- Achaete-scute homolog 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:2000026 (regulation of multicellular organismal development), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0035282 (segmentation), GO:0050768 (negative regulation of neurogenesis), GO:0001501 (skeletal system development), GO:0060284 (regulation of cell development), GO:0051960 (regulation of nervous system development), GO:0060485 (mesenchyme development), GO:0007498 (mesoderm development), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0010721 (negative regulation of cell development), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048339 (paraxial mesoderm development), GO:0050767 (regulation of neurogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)