Protein: Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) (P20701)
Organism: Homo sapiens (Human)
Function: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15684041, ECO:0000269|PubMed:16301335}; Single-pass type I membrane protein {ECO:0000255}. Note=Upon antigen recognition by the TCR, is recruited to lipid rafts (PubMed:15684041). {ECO:0000269|PubMed:15684041}.
Sequence: MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [771-917]
- IPR002035: von Willebrand factor, type A (domain) [154-329]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1112-1127]
- IPR000413: Integrin alpha chain (family) [401-1119]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [612-757]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [26-614]
- IPR013517: FG-GAP repeat (repeat) [460-554]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [614-914]
- IPR013519: Integrin alpha beta-propellor (repeat) [31-666]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [154-332]
Interaction partners: - Intercellular adhesion molecule 3
- Intercellular adhesion molecule 2
- Integrin beta-2
- Intercellular adhesion molecule 1
- Intercellular adhesion molecule 5
- Junctional adhesion molecule A
- Integrin alpha-M
- Vascular cell adhesion protein 1
- Integrin beta-1
- Integrin beta-7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0031072 (heat shock protein binding), GO:0001540 (amyloid-beta binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0098609 (cell-cell adhesion), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0002694 (regulation of leukocyte activation), GO:1901700 (response to oxygen-containing compound), GO:0050867 (positive regulation of cell activation), GO:0002696 (positive regulation of leukocyte activation), GO:0050776 (regulation of immune response), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0080090 (regulation of primary metabolic process), GO:0050865 (regulation of cell activation), GO:1903532 (positive regulation of secretion by cell), GO:0043300 (regulation of leukocyte degranulation), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0002703 (regulation of leukocyte mediated immunity), GO:0071310 (cellular response to organic substance), GO:0033003 (regulation of mast cell activation), GO:0033006 (regulation of mast cell activation involved in immune response), GO:0043302 (positive regulation of leukocyte degranulation), GO:0017157 (regulation of exocytosis), GO:0010628 (positive regulation of gene expression), GO:0045921 (positive regulation of exocytosis), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0017157 (regulation of exocytosis), GO:0031326 (regulation of cellular biosynthetic process), GO:0051046 (regulation of secretion), GO:1902533 (positive regulation of intracellular signal transduction), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0033008 (positive regulation of mast cell activation involved in immune response), GO:1901701 (cellular response to oxygen-containing compound), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling), GO:0043306 (positive regulation of mast cell degranulation), GO:0043304 (regulation of mast cell degranulation), GO:0002886 (regulation of myeloid leukocyte mediated immunity), GO:1903307 (positive regulation of regulated secretory pathway), GO:1903305 (regulation of regulated secretory pathway), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0043235 (receptor complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0098636 (protein complex involved in cell adhesion), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0098802 (plasma membrane signaling receptor complex), GO:0043229 (intracellular organelle), GO:0098797 (plasma membrane protein complex), GO:0043227 (membrane-bounded organelle), GO:0008305 (integrin complex), GO:0005886 (plasma membrane), GO:0101002 (ficolin-1-rich granule), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030667 (secretory granule membrane), GO:0070820 (tertiary granule), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0070821 (tertiary granule membrane), GO:0101003 (ficolin-1-rich granule membrane)