Protein: Exonuclease, putative (Q57YZ1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGIKGLWGEVKPVCRDAHLEKFRGSRVGVDMYVWLHRAVSGSVDLSTEANVEMLRAHVESLSDPSVTVSAHPIPLNTKFLHWVMSQVELLLRYGVKPVLVFDGRELPMKREEEEERRRNRIKHLSEALDLLRRNSRPTPSERKDIAGLVERGMDITTELAHAVIMMLQERQLECIVAPYEADAQLAYLCQQRYVDAVITEDSDLLVYWCPRLIAKLDHKGSCQVIEVESVLHCPLFKGLSYNSFLVGCILSGCDYLPNLRHIGVKKAFGIMSEARSVPDVIRLLEENYGFPREQLRKYEAGLQRAIYCFLHHIVFDPVKRALVTRTPLPNGVAFKQSILGELVGDDLAQSMCCQCLYDPTTRSLYKGIYQYCLDNYRKTSRAGQSTLTAFNGFKELRSPRMTLRLASSNSQASATSVSNTPLTPPTKTFFSAPLEKVREAEGYCGPKVVRSKYFVNGQWKVDNWEESSSQGGDSNTKNGNGDDSQSPSGAVTDECDAAGGVRSDGGKCCVKSEPPTPPDRVSCATLSCKASSVCQVAGASDSATADADRAVDPSHGEFRGTELTCSDVCGLTEVPCSNVEGSASALLQECGADAPNDPVGADRASVQDVNEGAEMLCPFGYIQCRRKHSLFEQCFVGKGWTKKANNPNDQNNGSGAQVVPQGDTDGDGGTSPWRTRGSAKRRWSEIESVQPSQSPPLVSSSSSFLHSIASTTASPLTVREANDAKTGGSCGGSVSVPCRMQSNSPKTLTEQCANGLATEDASDEGVNADFSASTSQSSVAAAPKAAALFELLSYTRR
InterPro domains: - IPR037315: Exonuclease-1, H3TH domain (domain) [242-316]
- IPR006086: XPG-I domain (domain) [168-254]
- IPR019974: XPG conserved site (conserved_site) [95-109]
- IPR006084: XPG/Rad2 endonuclease (family) [1-477]
- IPR029060: PIN-like domain superfamily (homologous_superfamily) [2-254]
- IPR044752: Exonuclease 1-like, PIN-like domain (domain) [1-232]
- IPR036279: 5'-3' exonuclease, C-terminal domain superfamily (homologous_superfamily) [239-332]
- IPR006085: XPG, N-terminal (domain) [1-123]
Interaction partners: - Endo/exonuclease Mre11
- Mismatch repair protein MLH1
- DNA mismatch repair protein, putative
- BRCT domain-containing protein
- Mismatch repair protein MSH8, putative
- Proliferating cell nuclear antigen
- Mismatch repair protein PMS1, putative
- Protein artemis
- DNA 3'-5' helicase
- DNA 3'-5' helicase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0004518 (nuclease activity), GO:0004536 (deoxyribonuclease activity), GO:0004520 (DNA endonuclease activity), GO:0004519 (endonuclease activity), GO:0048256 (flap endonuclease activity), GO:0016893 (endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0016888 (endodeoxyribonuclease activity, producing 5'-phosphomonoesters), GO:0017108 (5'-flap endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006260 (DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)