Protein: Tripartite motif-containing protein 60 (Q495X7)
Organism: Homo sapiens (Human)
Function: E3 SUMO-protein ligase that mediates SUMOylation of TAB2 leading to inhibition of NF-kappa-B and MAPK pathways by suppressing the TRAF6/TAB2/TAK1 complex
Sequence: MEFVTALVNLQEESSCPICLEYLKDPVTINCGHNFCRSCLSVSWKDLDDTFPCPVCRFCFPYKSFRRNPQLRNLTEIAKQLQIRRSKRKRQKENAMCEKHNQFLTLFCVKDLEILCTQCSFSTKHQKHYICPIKKAASYHREILEGSLEPLRNNIERVEKVIILQGSKSVELKKKVEYKREEINSEFEQIRLFLQNEQEMILRQIQDEEMNILAKLNENLVELSDYVSTLKHLLREVEGKSVQSNLELLTQAKSMHHKYQNLKCPELFSFRLTKYGFSLPPQYSGLDRIIKPFQVDVILDLNTAHPQLLVSEDRKAVRYERKKRNICYDPRRFYVCPAVLGSQRFSSGRHYWEVEVGNKPKWILGVCQDCLLRNWQDQPSVLGGFWAIGRYMKSGYVASGPKTTQLLPVVKPSKIGIFLDYELGDLSFYNMNDRSILYTFNDCFTEAVWPYFYTGTDSEPLKICSVSDSER
InterPro domains: - IPR003879: Butyrophylin-like, SPRY domain (domain) [293-454]
- IPR001841: Zinc finger, RING-type (domain) [16-57]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [288-466]
- IPR000315: B-box-type zinc finger (domain) [92-133]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [31-40]
- IPR006574: SPRY-associated (domain) [294-346]
- IPR001870: B30.2/SPRY domain (domain) [277-470]
- IPR003877: SPRY domain (domain) [347-467]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [288-471]
- IPR050143: Tripartite motif-containing (family) [10-464]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [3-81]
- IPR035786: TRIM60, PRY/SPRY domain (domain) [286-465]
Interaction partners: - Kinesin-like protein KIF3B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048525 (negative regulation of viral process), GO:0051707 (response to other organism), GO:0044093 (positive regulation of molecular function), GO:0043207 (response to external biotic stimulus), GO:1903900 (regulation of viral life cycle), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0052372 (modulation by symbiont of entry into host), GO:0009615 (response to virus), GO:1903901 (negative regulation of viral life cycle), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0046596 (regulation of viral entry into host cell), GO:0140546 (defense response to symbiont), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051607 (defense response to virus), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0046597 (negative regulation of viral entry into host cell), GO:0010468 (regulation of gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0044790 (suppression of viral release by host), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)