Protein: Monocarboxylate transporter 9 (M0RCI4)
Organism: Rattus norvegicus (Rat)
Function: Extracellular pH-and Na(+)-sensitive low-affinity creatine transporter. Also functions as a pH-independent carnitine efflux transporter (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MGFQKSPDGGWGWVIVVVSFFTQFLCYGSPLAVGVLYVEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLFVSSFGARPVTIFSGFLVAGGLMLSSLAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDSRRGLALGLISTGSSVGLFIYAALQRMLIEFYGLDGCLLIVGALALNILACGSLMRPLQTSDCPFPEKIAPENVPDRYSIYNEKEKNQEETMTFQDKGYSNEDKCLPNGDWGRETSLPKNPTGAAHTKEPEPYKKKVVEQTNFCKQLAKRKWQVYRNYCGETASLFKNKVFSALFVAILLFDIGGFPPSLLMEDVARSYHVREEDLTIPLISIFGIMTAVGKLLLGILADFKWVNTLYLYVATLIITGLALCAIPLAKSYVTLAILSGILGFLTGNWSIFPYVTTKTVGIDKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAILPCWGMCNQRLPKPAAPTTFFYKVASNV
InterPro domains: - IPR050327: Proton-linked Monocarboxylate Transporter (family) [7-479]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [7-483]
- IPR020846: Major facilitator superfamily domain (domain) [15-484]
- IPR011701: Major facilitator superfamily (family) [20-478]
- IPR030767: Monocarboxylate transporter 9 (family) [12-479]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015101 (organic cation transmembrane transporter activity), GO:0072349 (modified amino acid transmembrane transporter activity), GO:0015651 (quaternary ammonium group transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1903825 (organic acid transmembrane transport), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046415 (urate metabolic process), GO:0071705 (nitrogen compound transport), GO:0071702 (organic substance transport), GO:0072521 (purine-containing compound metabolic process), GO:1905039 (carboxylic acid transmembrane transport), GO:0015697 (quaternary ammonium group transport), GO:0015711 (organic anion transport), GO:0015695 (organic cation transport), GO:0072337 (modified amino acid transport), GO:0015849 (organic acid transport), GO:0046942 (carboxylic acid transport), GO:0015879 (carnitine transport), GO:0015838 (amino-acid betaine transport), GO:0015718 (monocarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)