Protein: Secretin receptor (SCT-R) (SECR) (P47872)
Organism: Homo sapiens (Human)
Function: Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5FWI2}; Multi-pass membrane protein {ECO:0000269|PubMed:32811827}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5FWI2}; Multi-pass membrane protein {ECO:0000269|PubMed:32811827}.
Sequence: MRPHLSPPLQQLLLPVLLACAAHSTGALPRLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSSVPGRMVEVECPRFLRMLTSRNGSLFRNCTQDGWSETFPRPNLACGVNVNDSSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLVMVLFQYCIMANYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFLEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQWHLREFPLHPVASFSNSTKASHLEQSQGTCRTSII
InterPro domains: - IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [44-132]
- IPR017983: GPCR, family 2, secretin-like, conserved site (conserved_site) [66-395]
- IPR000832: GPCR, family 2, secretin-like (family) [140-391]
- IPR002144: GPCR, family 2, secretin receptor (family) [2-439]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [14-150]
- IPR050332: G-protein coupled receptor 2 (family) [15-418]
- IPR017981: GPCR, family 2-like, 7TM (domain) [142-392]
- IPR047037: Secretin receptor, 7TM (domain) [139-405]
Interaction partners: - Secretin
- Guanine nucleotide-binding protein G
- Anoctamin-6
- VIP peptides
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Pituitary adenylate cyclase-activating polypeptide
- Pro-glucagon
- Adhesion G protein-coupled receptor A1
- Probable non-functional immunoglobulin heavy variable 3-16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009991 (response to extracellular stimulus), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0031668 (cellular response to extracellular stimulus), GO:0003013 (circulatory system process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0006091 (generation of precursor metabolites and energy), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0008015 (blood circulation), GO:0071310 (cellular response to organic substance), GO:0031667 (response to nutrient levels), GO:1901699 (cellular response to nitrogen compound), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:1901701 (cellular response to oxygen-containing compound), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0033762 (response to glucagon), GO:1901653 (cellular response to peptide), GO:0006812 (monoatomic cation transport), GO:0071375 (cellular response to peptide hormone stimulus), GO:0006816 (calcium ion transport), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0035725 (sodium ion transmembrane transport), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0030001 (metal ion transport), GO:0032869 (cellular response to insulin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)