Protein: Latent-transforming growth factor beta-binding protein 4 (LTBP-4) (Q8N2S1)
Organism: Homo sapiens (Human)
Function: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:16157329, ECO:0000269|PubMed:9660815}.
Sequence: MPRPGTSGRRPLLLVLLLPLFAAATSAASPSPSPSQVVEVPGVPSRPASVAVCRCCPGQTSRRSRCIRAFCRVRSCQPKKCAGPQRCLNPVPAVPSPSPSVRKRQVSLNWQPLTLQEARALLKRRRPRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVCVKPDRCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGSCEDVDECATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDFEALCNVLRPPAYSPPRPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEEPPEGGSYAGSLAEPYEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHCAPARPRA
InterPro domains: - IPR001881: EGF-like calcium-binding domain (domain) [357-1618]
- IPR017878: TB domain (domain) [287-1402]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [357-1602]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [372-1604]
- IPR050751: Extracellular matrix structural protein (family) [549-744]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [357-1617]
- IPR013032: EGF-like, conserved site (conserved_site) [556-576]
- IPR000742: EGF-like domain (domain) [149-1618]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [547-1619]
- IPR036773: TGF-beta binding (TB) domain superfamily (homologous_superfamily) [286-1408]
Interaction partners: - Transforming growth factor beta-1 proprotein
- Transforming growth factor beta-2 proprotein
- Latent-transforming growth factor beta-binding protein 3
- Transforming growth factor beta-3 proprotein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044085 (cellular component biogenesis), GO:0006810 (transport), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0032940 (secretion by cell), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0010817 (regulation of hormone levels), GO:0023061 (signal release), GO:0071559 (response to transforming growth factor beta), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0043062 (extracellular structure organization), GO:0009914 (hormone transport), GO:0046903 (secretion), GO:0045229 (external encapsulating structure organization), GO:0046879 (hormone secretion), GO:0071363 (cellular response to growth factor stimulus), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030198 (extracellular matrix organization), GO:0085029 (extracellular matrix assembly), GO:0007179 (transforming growth factor beta receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0031012 (extracellular matrix), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)