Protein: Thioredoxin-dependent peroxide reductase, mitochondrial (A0A384MTR2)
Organism: Homo sapiens (Human)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength
Sequence: MAAAVGRLLRASVARHVSAIPWGISATAALRPAACGRTSLTNLLCSGSSQAKLFSTSSSCHAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGSGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQYVETHGEVCPANWTPDSPTIKPSPAASKEYFQKVNQ
InterPro domains: - IPR000866: Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant (domain) [65-197]
- IPR013766: Thioredoxin domain (domain) [63-221]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [64-255]
- IPR050217: Thiol-specific antioxidant peroxiredoxin (family) [52-254]
- IPR019479: Peroxiredoxin, C-terminal (domain) [218-253]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0004601 (peroxidase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0043028 (cysteine-type endopeptidase regulator activity involved in apoptotic process), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor), GO:0042802 (identical protein binding), GO:0061134 (peptidase regulator activity), GO:0019899 (enzyme binding), GO:0051920 (peroxiredoxin activity), GO:0004857 (enzyme inhibitor activity), GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process), GO:0140824 (thioredoxin-dependent peroxiredoxin activity), GO:0019900 (kinase binding), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0008379 (thioredoxin peroxidase activity), GO:0004866 (endopeptidase inhibitor activity), GO:0019901 (protein kinase binding), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0006979 (response to oxidative stress), GO:0072593 (reactive oxygen species metabolic process), GO:0044092 (negative regulation of molecular function), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0042743 (hydrogen peroxide metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0010035 (response to inorganic substance), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0042391 (regulation of membrane potential), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0008284 (positive regulation of cell population proliferation), GO:0034599 (cellular response to oxidative stress), GO:0043086 (negative regulation of catalytic activity), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0042744 (hydrogen peroxide catabolic process), GO:0062197 (cellular response to chemical stress), GO:0051881 (regulation of mitochondrial membrane potential), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0031326 (regulation of cellular biosynthetic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0042542 (response to hydrogen peroxide), GO:0051338 (regulation of transferase activity), GO:0006996 (organelle organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0051174 (regulation of phosphorus metabolic process), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0007005 (mitochondrion organization), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0018193 (peptidyl-amino acid modification), GO:0019220 (regulation of phosphate metabolic process), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0034614 (cellular response to reactive oxygen species), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0018198 (peptidyl-cysteine modification), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)