Protein: Sodium channel protein (E9PHB6)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
Sequence: MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV
InterPro domains: - IPR008053: Voltage gated sodium channel, alpha-5 subunit (family) [297-1039]
- IPR010526: Sodium ion transport-associated domain (domain) [953-1199]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [122-1585]
- IPR001696: Voltage gated sodium channel, alpha subunit (family) [1721-1769]
- IPR024583: Voltage-gated Na+ ion channel, cytoplasmic domain (domain) [508-667]
- IPR043203: Voltage-gated cation channel calcium and sodium (family) [48-1571]
- IPR044564: Voltage-gated sodium channel alpha subunit, inactivation gate (domain) [1470-1522]
- IPR005821: Ion transport domain (domain) [130-1749]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0097110 (scaffold protein binding), GO:0022803 (passive transmembrane transporter activity), GO:0005516 (calmodulin binding), GO:0008092 (cytoskeletal protein binding), GO:0019838 (growth factor binding), GO:1901702 (salt transmembrane transporter activity), GO:0044325 (transmembrane transporter binding), GO:0019904 (protein domain specific binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0019900 (kinase binding), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017134 (fibroblast growth factor binding), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0050998 (nitric-oxide synthase binding), GO:0030506 (ankyrin binding), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0031625 (ubiquitin protein ligase binding), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0019901 (protein kinase binding), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0032879 (regulation of localization), GO:0060306 (regulation of membrane repolarization), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:0030029 (actin filament-based process), GO:0007154 (cell communication), GO:0086019 (cell-cell signaling involved in cardiac conduction), GO:0098660 (inorganic ion transmembrane transport), GO:0044057 (regulation of system process), GO:0034220 (monoatomic ion transmembrane transport), GO:0032970 (regulation of actin filament-based process), GO:0003013 (circulatory system process), GO:0010035 (response to inorganic substance), GO:0002027 (regulation of heart rate), GO:0043270 (positive regulation of monoatomic ion transport), GO:0042391 (regulation of membrane potential), GO:1902074 (response to salt), GO:0086065 (cell communication involved in cardiac conduction), GO:0030048 (actin filament-based movement), GO:0051049 (regulation of transport), GO:0034762 (regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0003012 (muscle system process), GO:0003254 (regulation of membrane depolarization), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0099623 (regulation of cardiac muscle cell membrane repolarization), GO:0098655 (monoatomic cation transmembrane transport), GO:0010765 (positive regulation of sodium ion transport), GO:0008015 (blood circulation), GO:1902075 (cellular response to salt), GO:0006936 (muscle contraction), GO:0090257 (regulation of muscle system process), GO:1903522 (regulation of blood circulation), GO:0001508 (action potential), GO:0051592 (response to calcium ion), GO:0003015 (heart process), GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization), GO:1901701 (cellular response to oxygen-containing compound), GO:0010038 (response to metal ion), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0086091 (regulation of heart rate by cardiac conduction), GO:0006811 (monoatomic ion transport), GO:1903115 (regulation of actin filament-based movement), GO:0051899 (membrane depolarization), GO:0098662 (inorganic cation transmembrane transport), GO:0071241 (cellular response to inorganic substance), GO:0070252 (actin-mediated cell contraction), GO:0060371 (regulation of atrial cardiac muscle cell membrane depolarization), GO:0043269 (regulation of monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0035725 (sodium ion transmembrane transport), GO:0010959 (regulation of metal ion transport), GO:0086004 (regulation of cardiac muscle cell contraction), GO:0006941 (striated muscle contraction), GO:0008016 (regulation of heart contraction), GO:0086001 (cardiac muscle cell action potential), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0006937 (regulation of muscle contraction), GO:0060047 (heart contraction), GO:0071277 (cellular response to calcium ion), GO:0071248 (cellular response to metal ion), GO:0086003 (cardiac muscle cell contraction), GO:0086010 (membrane depolarization during action potential), GO:0061337 (cardiac conduction), GO:0030001 (metal ion transport), GO:0086002 (cardiac muscle cell action potential involved in contraction), GO:0055117 (regulation of cardiac muscle contraction), GO:1902305 (regulation of sodium ion transmembrane transport), GO:0006942 (regulation of striated muscle contraction), GO:0060048 (cardiac muscle contraction), GO:0002028 (regulation of sodium ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)