Protein: Seipin-2 (AtSEIPIN2) (F4I340)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Supports the formation of small-sized LDs and modulates triacylglycerol accumulation. Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26362606}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the lipid droplet-forming sites. {ECO:0000269|PubMed:26362606}.
Sequence: MDSESESESNPSTTDEFDRFLDAPDEFYYDCLPIRSNSHQPSSLLRRRKSAHRRDLISSDIETEPSSSSDGFDVGEKSSYVEKNAELRGDIDTSDVIESTKDSIDLSSEKENDLDVISSSGNDMDVIDSGRNRVDPFQEESTVTTVSSDDQGDDDYAGSVPQFREPPNSTEWSLLGFLVGLVIKAIEFQVSFMTSLLTFPPWLLRNCFLFFFDPFSTIRFGRRFLMARVAGISDMIFGYMNPFRLKDTKQMLSIVCKFGWGMFWAVYVGIVLFGLLVSSLMIGGYVINRIADKPFEVKETLNFDYTKNSPEAYVPISSCAGVECEGSCKESNEMSKIRGLRVIPRDQKLDIILSMTLPESAYNKNLGMFQVRVDFLSVDGQTIASIRRPCMLRFRSEPIRLVQTFFKVVPLVTGYVSEIQTLSLKLKGFVEKDIPTACLKIIIEQRAEFRPGAGIPELYDASLSVESGLPFFRKIIWKWRKTLFVWISMSLFITELLFTLVCCRPLIIPRTQPRDRSPSNPTGVWR
InterPro domains: - IPR009617: Seipin family (family) [98-521]
Interaction partners: - Voltage-dependent L-type calcium channel subunit
- Protein C2-DOMAIN ABA-RELATED 2
- REF/SRPP-like protein At3g05500
- REF/SRPP-like protein At1g67360
- Transmembrane 9 superfamily member 8
- Alpha/beta-Hydrolases superfamily protein
- Oleosin 18.5 kDa
- G-box-binding factor 1
- Glycine-rich domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009856 (pollination), GO:0048856 (anatomical structure development), GO:0010162 (seed dormancy process), GO:0044706 (multi-multicellular organism process), GO:0007275 (multicellular organism development), GO:0022611 (dormancy process), GO:2000241 (regulation of reproductive process), GO:0051235 (maintenance of location), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0009846 (pollen germination), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0033036 (macromolecule localization), GO:0009791 (post-embryonic development), GO:0010876 (lipid localization), GO:0048316 (seed development), GO:0080154 (regulation of fertilization), GO:0044085 (cellular component biogenesis), GO:0019915 (lipid storage), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0048608 (reproductive structure development), GO:0010431 (seed maturation), GO:0071695 (anatomical structure maturation), GO:0061458 (reproductive system development), GO:0140042 (lipid droplet formation), GO:0006996 (organelle organization), GO:0010154 (fruit development), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0034389 (lipid droplet organization), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)