Protein: Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) (Deubiquitinating enzyme 7) (Q9VYQ8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Hydrolase that deubiquitinates target proteins.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q93009}.
Sequence: MEIETDQSIEAMDTQDTQEVEILTSDLQQTQQQRNSPPQLPKFKNLIQPQLHAVGAVTQLPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPVYVRMLPWRIMVIPNDRALGFFLQCNGENDSPTWSCNAIAELRLKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELDNKKQFKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAEDMQLAENEFLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFCVISMGHNADVNDNTPVDLEVYRSWTSGQLPFFGLDHINKSRKRSSLNFSEKAIKIYN
InterPro domains: - IPR024729: Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain (domain) [647-886]
- IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [102-550]
- IPR029346: Ubiquitin carboxyl-terminal hydrolase, C-terminal (domain) [898-1113]
- IPR002083: MATH/TRAF domain (domain) [101-222]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [242-491]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [241-545]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [236-574]
- IPR008974: TRAF-like (homologous_superfamily) [97-237]
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [241-548]
Interaction partners: - GMP synthase
- Ubiquitin carboxyl-terminal hydrolase
- Ubiquitin-ribosomal protein eL40 fusion protein
- Forkhead box protein O
- Ubiquitin-ribosomal protein eS31 fusion protein
- GH17761p
- Daxx-like protein
- Polyubiquitin
- BcDNA.LD22910
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0031647 (regulation of protein stability), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009894 (regulation of catabolic process), GO:0009887 (animal organ morphogenesis), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0042177 (negative regulation of protein catabolic process), GO:0006508 (proteolysis), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0031330 (negative regulation of cellular catabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0006325 (chromatin organization), GO:0030111 (regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0036211 (protein modification process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0050821 (protein stabilization), GO:0034330 (cell junction organization), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0030162 (regulation of proteolysis), GO:1901799 (negative regulation of proteasomal protein catabolic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0150063 (visual system development), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0048699 (generation of neurons), GO:0070646 (protein modification by small protein removal), GO:2000059 (negative regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0045861 (negative regulation of proteolysis), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0090263 (positive regulation of canonical Wnt signaling pathway), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0001933 (negative regulation of protein phosphorylation), GO:0048749 (compound eye development), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0032435 (negative regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:1903051 (negative regulation of proteolysis involved in protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0001745 (compound eye morphogenesis), GO:0016579 (protein deubiquitination), GO:0001754 (eye photoreceptor cell differentiation), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0042051 (compound eye photoreceptor development), GO:0001751 (compound eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)