Protein: SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor) (Q9WTP3)
Organism: Mus musculus (Mouse)
Function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MGSASPGLSNVSPGCLLLFPDVAPRTGTEKAASGAMGPEKQEWSPSPPATPEQGLSAFYLSYFNMYPDDSSWVAKVPEARAGEDHPEEPEQCPVIDSQASGSTLDEHSLEQVQSMVVGEVLKDIETACKLLNITADPGDWSPGNVQKWLLWTEHQYRLPPAGKAFQELGGKELCAMSEEQFRQRAPLGGDVLHAHLDIWKSAAWMKERTSPGTLHYCASTSEEGWTDGEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGVRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPV
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [234-323]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [105-206]
- IPR000418: Ets domain (domain) [238-325]
- IPR003118: Pointed domain (domain) [119-203]
- IPR046328: ETS family (family) [135-322]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [207-325]
Interaction partners: - Anterior gradient protein 2 homolog
- Homeobox protein Nkx-2.1
- Mucin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001217 (DNA-binding transcription repressor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0009653 (anatomical structure morphogenesis), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0002262 (myeloid cell homeostasis), GO:0048522 (positive regulation of cellular process), GO:0002695 (negative regulation of leukocyte activation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0072089 (stem cell proliferation), GO:0008285 (negative regulation of cell population proliferation), GO:0048513 (animal organ development), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:1903706 (regulation of hemopoiesis), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0046649 (lymphocyte activation), GO:1903707 (negative regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0050866 (negative regulation of cell activation), GO:0042127 (regulation of cell population proliferation), GO:0007162 (negative regulation of cell adhesion), GO:0031325 (positive regulation of cellular metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0050865 (regulation of cell activation), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022407 (regulation of cell-cell adhesion), GO:0060284 (regulation of cell development), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0070664 (negative regulation of leukocyte proliferation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042110 (T cell activation), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0022408 (negative regulation of cell-cell adhesion), GO:0010721 (negative regulation of cell development), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051249 (regulation of lymphocyte activation), GO:0050670 (regulation of lymphocyte proliferation), GO:0045619 (regulation of lymphocyte differentiation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:1903131 (mononuclear cell differentiation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0050868 (negative regulation of T cell activation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042130 (negative regulation of T cell proliferation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0042129 (regulation of T cell proliferation), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045581 (negative regulation of T cell differentiation), GO:0045580 (regulation of T cell differentiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0033081 (regulation of T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)