Protein: Delta-like protein 4 (D3ZHH1)
Organism: Rattus norvegicus (Rat)
Function: Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence: MTPGSRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFANERGMLANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGRGSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIATEV
InterPro domains: - IPR000742: EGF-like domain (domain) [175-519]
- IPR051830: Neurogenic locus notch homolog (family) [367-625]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [340-351]
- IPR001774: Delta/Serrate/lag-2 (DSL) protein (domain) [156-221]
- IPR001881: EGF-like calcium-binding domain (domain) [285-519]
- IPR013032: EGF-like, conserved site (conserved_site) [295-317]
- IPR011651: Notch ligand, N-terminal domain (domain) [28-174]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [390-519]
Interaction partners: - Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 4
- Neurogenic locus notch homolog protein 2
- Neurogenic locus notch homolog protein 3
- Delta-like protein 1
- Delta-like protein 3
- Recombining binding protein suppressor of hairless
- Ephrin-B2
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005112 (Notch binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0001709 (cell fate determination), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0051962 (positive regulation of nervous system development), GO:0045746 (negative regulation of Notch signaling pathway), GO:0050768 (negative regulation of neurogenesis), GO:0007399 (nervous system development), GO:0008593 (regulation of Notch signaling pathway), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0007417 (central nervous system development), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0010721 (negative regulation of cell development), GO:0048710 (regulation of astrocyte differentiation), GO:0014014 (negative regulation of gliogenesis), GO:0050767 (regulation of neurogenesis), GO:0045686 (negative regulation of glial cell differentiation), GO:0048712 (negative regulation of astrocyte differentiation), GO:0014013 (regulation of gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)