Protein: Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) (P00920)
Organism: Mus musculus (Mouse)
Function: Catalyzes the reversible hydration of carbon dioxide (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (By similarity). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P00918}. Cell membrane {ECO:0000250|UniProtKB:P00918}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000250|UniProtKB:P00918}.
Sequence: MSHHWGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAQHDPALQPLLISYDKAASKSIVNNGHSFNVEFDDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKIGPASQGLQKVLEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASFK
InterPro domains: - IPR036398: Alpha carbonic anhydrase domain superfamily (homologous_superfamily) [1-260]
- IPR018338: Carbonic anhydrase, alpha-class, conserved site (conserved_site) [105-121]
- IPR001148: Alpha carbonic anhydrase domain (domain) [3-259]
- IPR023561: Carbonic anhydrase, alpha-class (family) [3-253]
Interaction partners: - Sodium/hydrogen exchanger 1
- Band 3 anion transport protein
- Electrogenic sodium bicarbonate cotransporter 1
- Carbonic anhydrase 1
- Monocarboxylate transporter 1
- Sodium bicarbonate cotransporter 3
- Cathepsin K
- Chloride anion exchanger
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0016151 (nickel cation binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0098858 (actin-based cell projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005902 (microvillus)