Protein: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase) (PGP synthase) (Q9HDW1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
Subcellular location: Mitochondrion {ECO:0000250}.
Sequence: MDEGIEKNIFVNLESQIDGVCPKFYVNVDDIDIIHEPPEFYQRLKKLIKKAQKRIFLSTLYIGKEERELINCLSNALSNNPSLHVHILADQLRCTRESPGCCSASLLMQLKKKFPDRCEIKLYHTPNLRGLRKQLVPHRFNEGWGLQHMKIYGADDNLIISGANLSRDYFTNRKDRYYLFSDKGLADFFFKTHFLFSQLSFECIPHLSDSSIQLSSTSPVIPFTLKWNNSCPNPLTNPQEFRVAASAKIQQLLQGNREKFLSRNPSKPLSSVYGSELINQAGDDNNKPFHKYEESAIVYPLFQCVPILTSDVHSTEEKVLSIIGTLLSRKEVNWTLTAGYFNVYPALRKQLLKSEGIGEVIVASQQANGFYRSPGPSKLIPPAYQYIAEQFLKDSRKKKRNIDVLQWQNKGNTYHAKGFWLSTQHHKHPFLTTIGSSNYTSRSQQLDLESTLVVMTQNEKLKRKFSTEIELIKQHTKPMNTCQLEKVPMYVKALTSLMKKKL
InterPro domains: - IPR016270: CDP-alcohol phosphatidyltransferase class-II family (family) [12-501]
- IPR001736: Phospholipase D/Transphosphatidylase (domain) [143-443]
Interaction partners: - Putative phosphatidate cytidylyltransferase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Probable phosphatidylglycerophosphatase, mitochondrial
- CDP-diacylglycerol--serine O-phosphatidyltransferase
- Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein C22A12.10
- Phosphatidylethanolamine N-methyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016780 (phosphotransferase activity, for other substituted phosphate groups), GO:0017169 (CDP-alcohol phosphatidyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006793 (phosphorus metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0046471 (phosphatidylglycerol metabolic process), GO:0006655 (phosphatidylglycerol biosynthetic process), GO:0032049 (cardiolipin biosynthetic process), GO:0032048 (cardiolipin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)