Protein: Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32) (P08101)
Organism: Mus musculus (Mouse)
Function: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.
Subcellular location: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform IIB1]: Cytoplasm, cytoskeleton. Note=Binds the cytoskeleton and is not localized in endocytotic pits.; SUBCELLULAR LOCATION: [Isoform IIB3]: Secreted. Note=Released as a soluble molecule.
Sequence: MESNWTVHVFSRTLCHMLLWTAVLNLAAGTHDLPKAVVKLEPPWIQVLKEDTVTLTCEGTHNPGNSSTQWFHNGRSIRSQVQASYTFKATVNDSGEYRCQMEQTRLSDPVDLGVISDWLLLQTPQLVFLEGETITLRCHSWRNKLLNRISFFHNEKSVRYHHYSSNFSIPKANHSHSGDYYCKGSLGRTLHQSKPVTITVQGPKSSRSLPVLTIVAAVTGIAVAAIVIILVSLVYLKKKQVPALPGNPDHREMGETLPEEVGEYRQPSGGSVPVSPGPPSGLEPTSSSPYNPPDLEEAAKTEAENTITYSLLKHPEALDEETEHDYQNHI
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [34-202]
- IPR007110: Immunoglobulin-like domain (domain) [34-111]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [33-202]
- IPR003599: Immunoglobulin domain subtype (domain) [42-201]
- IPR050488: Immunoglobulin Fc region receptor (family) [30-205]
Interaction partners: - Galectin-3
- B-lymphocyte antigen CD19
- Tyrosine-protein kinase Lyn
- High affinity immunoglobulin gamma Fc receptor I
- Receptor-type tyrosine-protein phosphatase C
- Tyrosine-protein kinase SYK
- Integrin alpha-M
- T-cell surface glycoprotein CD4
- Adhesion G protein-coupled receptor E1
- C-reactive protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0044877 (protein-containing complex binding), GO:0038023 (signaling receptor activity), GO:0019865 (immunoglobulin binding), GO:0004888 (transmembrane signaling receptor activity), GO:0140375 (immune receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0051051 (negative regulation of transport), GO:0042221 (response to chemical), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051049 (regulation of transport), GO:0051282 (regulation of sequestering of calcium ion), GO:0098660 (inorganic ion transmembrane transport), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:0060627 (regulation of vesicle-mediated transport), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0051048 (negative regulation of secretion), GO:0046907 (intracellular transport), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0043271 (negative regulation of monoatomic ion transport), GO:0007166 (cell surface receptor signaling pathway), GO:0050858 (negative regulation of antigen receptor-mediated signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0050765 (negative regulation of phagocytosis), GO:0030100 (regulation of endocytosis), GO:0034097 (response to cytokine), GO:0071310 (cellular response to organic substance), GO:1905153 (regulation of membrane invagination), GO:0051209 (release of sequestered calcium ion into cytosol), GO:0071702 (organic substance transport), GO:0006811 (monoatomic ion transport), GO:0050764 (regulation of phagocytosis), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0050854 (regulation of antigen receptor-mediated signaling pathway), GO:0051926 (negative regulation of calcium ion transport), GO:0016192 (vesicle-mediated transport), GO:0043269 (regulation of monoatomic ion transport), GO:1901701 (cellular response to oxygen-containing compound), GO:0006812 (monoatomic cation transport), GO:0010959 (regulation of metal ion transport), GO:0071345 (cellular response to cytokine stimulus), GO:0070588 (calcium ion transmembrane transport), GO:0006897 (endocytosis), GO:1904645 (response to amyloid-beta), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0006816 (calcium ion transport), GO:0050853 (B cell receptor signaling pathway), GO:0030001 (metal ion transport), GO:0051924 (regulation of calcium ion transport), GO:1903169 (regulation of calcium ion transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)