Protein: Zinc transporter 7 (Q8NEW0)
Organism: Homo sapiens (Human)
Function: Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Sarcoplasmic reticulum. Mitochondrion
Sequence: MLPLSIKDDEYKPPKFNLFGKISGWFRSILSDKTSRNLFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFDSTAILAGLAASVISKWRDNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALAPPDVHHERLLLVSILGFVVNLIGIFVFKHGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSHDGPSLKETTGPSRQILQGVFLHILADTLGSIGVIASAIMMQNFGLMIADPICSILIAILIVVSVIPLLRESVGILMQRTPPLLENSLPQCYQRVQQLQGVYSLQEQHFWTLCSDVYVGTLKLIVAPDADARWILSQTHNIFTQAGVRQLYVQIDFAAM
InterPro domains: - IPR002524: Cation efflux (family) [35-371]
- IPR027469: Cation efflux transmembrane domain superfamily (homologous_superfamily) [33-295]
- IPR058533: Cation efflux protein, transmembrane domain (domain) [38-294]
- IPR045316: Zinc transporter Msc2-like (family) [15-372]
Interaction partners: - Alkaline phosphatase, tissue-nonspecific isozyme
- Zinc transporter SLC39A7
- Zinc transporter ZIP9
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP11
- Zinc transporter ZIP1
- Zinc transporter ZIP13
- Metal cation symporter ZIP14
- Zinc transporter ZIP5
- Zinc transporter ZIP6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0046872 (metal ion binding), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046914 (transition metal ion binding), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0051651 (maintenance of location in cell), GO:0051235 (maintenance of location), GO:0050801 (monoatomic ion homeostasis), GO:0051238 (sequestering of metal ion), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006882 (intracellular zinc ion homeostasis), GO:0006812 (monoatomic cation transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0000139 (Golgi membrane), GO:0097708 (intracellular vesicle)