Protein: Eye transformer, isoform B (MIP10547p) (Q9VWE1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MGWRTRISRLLSLTLLATLMARALAENALHMPQANCEMQSLGGPSWRSGTIGKVSCKCDGGEGRKMSVRRQGTIESTDSYNGTVVHVDANPANEWERRYECLLDGVIQSHVCVRVYALLNLKDFVCRDVVYYLRCTFSRMENGNFENKTHYQLAMGRAKPIDCRKSEDERSRGKVECSVPIDPNSRAPEWRDFRLIMSDDLGNQSKVLRLTQAEMEVLEWPRGKHNMIQTPNQTCLEWNGPFIYPNRTFELNVQFRHSKLPNLSRNLTVSQMRAVSVFDQVCFGNPPEGNQLFYVSLSRRLHGSPWSERYPEFELTTNASLPARPPRFLANGFSHDRAKRELKVYWLPLDELEFNGAEQTYVASTRTKVATTQGSMLAIFTDWDDTQPATVSVWSSNVVGRSLESSQLEVPRLSDIRDRRIYLESYNKTSSRLSWQGPEELGNFTGYIVYWCKLSSKVHDACDDSSSIETTYARETAYNFSGIQGVIRMAVAANYSDGLTTGMRWWSGDSEVPEKPKILRYVEGTIALLVLGSLVLAIQKLRQMADIRVELPVMSEEPTANPLGDVRLFYPANVPPEKFYGTVRKTVTFAEEEPTRWPEIELQEVPRPQPVPQADAYVTNQYVSMSAIGAPCGDGYIKPPPVR
InterPro domains: - IPR003529: Long hematopoietin receptor, Gp130 family 2, conserved site (conserved_site) [397-451]
- IPR003961: Fibronectin type III (domain) [427-482]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0019900 (kinase binding), GO:0046982 (protein heterodimerization activity), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0019901 (protein kinase binding), GO:0097677 (STAT family protein binding), GO:1990782 (protein tyrosine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0009892 (negative regulation of metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009617 (response to bacterium), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0098542 (defense response to other organism), GO:1904893 (negative regulation of receptor signaling pathway via STAT), GO:0051246 (regulation of protein metabolic process), GO:0042742 (defense response to bacterium), GO:0051248 (negative regulation of protein metabolic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0051174 (regulation of phosphorus metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:0045936 (negative regulation of phosphate metabolic process), GO:0046426 (negative regulation of receptor signaling pathway via JAK-STAT), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0042509 (regulation of tyrosine phosphorylation of STAT protein), GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)