Protein: VWFA domain-containing protein (Q57ZW5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSGSSLACNRDVSLTIGDVTVPVPANVSHPERVTWVLPGDTTNSGAFHIGEDAADELSLDVGDMFFHLGDNATRQYLRWICQKELLKQDMCLTGEPGPALRWLVLLYSRLTRREVQCVSLNRDTNEGDLGQRREIRNGTLSYEDQSVVIAAREGQLLLLEGLERVERNVLPVINNLLENREMHLENGMVLIHPERYDKIFNEALCEELKGGRQDANVEGGIGNQIPQAVHAKLQRMGFIRVSESFRVIGITAPVPPYDGTPLDPPLRSRFQCLYVDLPPPTLAATNVTNMAPGGRARGVFESLLKLRASIEEMNARTRGFTSGGTQGRDSAVGGCVSSLCGLQTIGSYEVAQVFRQFMLFPDVPVSELLLRSFPWTLYAQQTGSGSGTYEESMRRLRDYERVLAACDIGTPLSNHICHHSDVSVRDSGKPTDHCTHEDCAVRSSKHYNDVVFIDNVRVAKSKVLAVLQHPVVVGDACVDGMKGKYQLPLYLGEFALKSSRGGPSSPSSGRKWRTVDVKVYCSSSSTVFTPGHVHVLQSMLQLHIAGRHILLLGSSGSGKTTLLHEFARLLGYQTETMYLYADMTIKDLFQRRATDSVSGDTVWQNSALVDAALNGRMAVLDGIDKMPLGMLSSLQQLLIDGSTSLCDGSVLKSFKEYGIIKEKLRATEEEMKARRIFPIHPSFRVVGTARFPALNSNGTGNKVWQNQWRVTHDVTELFGVVQMPSCSQSLFRAILLRVAELELQFCGNEKVDGIRASVGPEGGISSGLKRDVDTLLRLRDELERLQVTEPKTPQLSLRQLLNLTRFRVRYPDDFNISVESTLLLPLLSSLVAEKVRQVMQICGFTCTSGLAERKQDPLRSSSVSKSSMGETLNCHSLKEFLLPCDPTIPNAGAGKAEGIEVSRVFGLGDKPILRINRNYGAKEKAMVPHVPHFHPNPVHESVIVWLAKQYAVGNNILLIGNQGVGKNKVVDAFLARVGTPREYIQLHRDTTVGSLTINPTVENGRVVWADSPLVRAVQQGHCLVVDEIDKAPVEVVQVLKGLIEDHEMRLRDGRQILGPRAHVVRFSISSSDYGSSEQKNIINMHPDFRVIVLANPPGFPFHGNDFYRECGDLFAPSVMLNADAHSQLQVLRAYGVNIPDALLMSLIECFQRLQTDFEEGNITYPFSLRELIAVVRHMSMFPGDGVYAALNNIFNFDVFDENTLRLVRNVLRLHLDPLVQFGGMQKLLPLRTSRAVPLRPSPSLIHMSAKSPAFLPLKLGEVVMSLPVRRLTDLECGGAINWKSAPVWCESYNATDFAADVSANGGLVGFSEWTTATRLPFLQQGDRVIRVAVEAPECVVGESKSVAVLFTRQHVLREEMNGSSSPLATTEIFLAIASLPSVASIAATAVGRKRLAAGQVQLLNLTDLLPLNSLPSSSLRFLGTEASGILASQALKESSHGAFGTSPSFVEVACASSGSILLADASALGLCSTSTALPRGQVRGQGDAAGDKLLGSVLVVHLMPPSSDVALTRHTVCPGCNLVAMTRPREPELYVWSNGHRVGVTLPAEDIRGIHFFANNYASVHLSKSESTFCGVMKLSLMSDGVATASLCLLPNEINGVVVGLTGTKEPTPTEAAMGPVTPEELQGAIIVAGAGSDSEKEGVLYTMVESYSSRSQSWSMRTFANPSISPAVCSDLNHHGTIGIDRVHKQLVVASGSDGVDTCGSLFAVDYHHHTVRHFAPTPTTSSRSSSVKPSYPCFSLDEVAGNILRYDEVNRQLLIGDLVAERVECRHRQLSALLQGSVKQVGAAAATPQGKLSMSYCTSRYAASNNLKHGREDNEEHHGGNTYAGGTGGTDTAGLGGLVGPYRLDKGWPVHQVSPEAKQQVPQHIIEEARRMGRVALQERLREIGMTSTEYERYGALQGRVRAPVAILRSMLSGLKAAEGERVWLRGQTDGVWDDSKIVEGIVGERNIYKRRADYADASPFQLKRKKRLLFVLDVSASMYRFEGMDQRLTKLLESTVMVMEAFTGYEEKIDYAMVGHNGDSACIELVPFGKPPTNQKERAEVCQRMVAHAQYCWSGDNTVQAMRQSIELVTAEKGEAYLVFVISDANLSRYGIEPGELGEIMESNQEVQMFCIFIATLGEQALNLREKLPSGHGFECMDTQALPHILKQIFLSVNLL
InterPro domains: - IPR011704: ATPase, dynein-related, AAA domain (domain) [89-1101]
- IPR002035: von Willebrand factor, type A (domain) [1972-2161]
- IPR003593: AAA+ ATPase domain (domain) [545-1120]
- IPR039891: von Willebrand factor A domain-containing protein 8 (family) [12-2162]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [70-1182]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [1967-2159]
Interaction partners: - Telomerase-associated protein, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0007017 (microtubule-based process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:0006473 (protein acetylation), GO:0018205 (peptidyl-lysine modification), GO:0018394 (peptidyl-lysine acetylation), GO:0006475 (internal protein amino acid acetylation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)