Protein: Breast cancer anti-estrogen resistance protein 1 (B5DE36)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, focal adhesion. Cell projection, axon. Cytoplasm
Sequence: MNYLNVLAKALYDNVAESPDELSFRKGDIMTVLERDTQGLEGWWLCSLHGRQGIVPGNRLKILVGMYDKQQQQQLQQLANQPSPTQSLINLPQSAYNKIPPAAQYTAMHPAFTPSGSANSTNPDGVYMLPPSHGSSLYQVPSGPPTPQPQPKAPALAKKQTHVQYPPTTQDVYQVPPSINAPGQDIYQVPPAAGGQCPGQDVYQVPPSVNQTQDVYQIPPSLDRSWDSPKPMGKVVVPTRVGQVYVYDTGKNEQDEYDVPRHLPPSQDIYDVPPTRTQYIQQVYDTPPMAMKGPPSGQEIYDTPPSVDKSQLHYQQTVYDIPPSVSKDVPDGPIREETYDVPPHFAKMKSLENQNQAYLSQIPGGPEPPIPEDVYDVPPPQLIGKRQPEGQEIYDIPASLRKGGPQDHHPTDVYDFPRERPAGEDSGDYVYDVPPQVVRDAAATEELTVSFKRLSASSTGSTRSNLSTSSLDMVPVRESSGPGRLLLLDLDQAMERLSRHQQAVESSVSLLMSFISGNWRSSTQMESNLPAIRQAVDRIRVAVRDLLEFARGAVANATQATDRTLQTKLGKQVQKMEEAFQGLVRYSQALDTLGWSPAALMTSQPGTGGDDLDRLIMCARGVPDDTKQLASFLHGNASLLFKRTNKQQQLPLPPVPHTGDSLTNNNNISAYQSGTPERANIQSRPLPSPPKFSAEEEAPDRPYETTEEGWMEDYDYVHLQGKEEFEKNQRQLLEKGSIKQNKTQLEQQQLKQFERLEQEVSRPINNDISGWTPPSHYPQTQRSKLCMGDRQLLLFYMEQCEANITTLTNAIDAFYSSINNNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKSPEVRTRVAQHSNTLCDKLKDIVVSTKTAALQYPSPGSTRDMTERVRELAGCTQQFRMALNQLLAM
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [6-91]
- IPR001452: SH3 domain (domain) [3-65]
- IPR037362: CAS family (family) [1-918]
- IPR014928: Serine rich protein interaction domain (domain) [488-644]
- IPR038319: CAS, serine rich four helix bundle domain superfamily (homologous_superfamily) [476-646]
- IPR035745: BCAR1, SH3 domain (domain) [4-70]
- IPR021901: CAS family, C-terminal (domain) [705-913]
Interaction partners: - Adapter molecule crk
- Crk-like protein
- CRK SH3-binding GNRP
- Tyrosine-protein kinase
- Integrin alpha-9
- Proto-oncogene tyrosine-protein kinase Src
- Integrin alpha-3b isoform X2
- Integrin beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0017124 (SH3 domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0016477 (cell migration), GO:0022008 (neurogenesis), GO:0048864 (stem cell development), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0035051 (cardiocyte differentiation), GO:0097435 (supramolecular fiber organization), GO:0007507 (heart development), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0055002 (striated muscle cell development), GO:0055013 (cardiac muscle cell development), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0060271 (cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0030055 (cell-substrate junction), GO:0005925 (focal adhesion)