Protein: long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (A0A0B4KFE4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MDSFWVQSAIGAIKAIAFVYDIITLPVYLVLQKPWKRRQDSRRVKAKPINQKMLVDESKYAPDDIEAKIVRNDDNELTYRTTDPPRDVHVKMLQENIDTLEKVFNYVAKTYTSKRCLGTRQILSEEDEVQQNGRVFKKYNLGDYKWKTFTEAERTAANFGRGLRELGQKPRENIVIFAETRAEWMIAAHGCFKQAMPIVTVYATLGDDGVAHCITETEVTTVITSHDLLPKFKTLLDKCPLVKTIIYIEDQLQKTETTGFKEGVKILPFNQVVKTGQDSKFEHVPPKGDDIAIIMYTSGSTGTPKGVLLSHKNCIATMKGFVDMVPIYPDDVLIGFLPLAHVFELVAESVCLMTGVPIGYSTPLTLIDTSSKIKRGCKGDATVLKPTCMTSVPLILDRISKGINDKVNSGSAFKKSLFKFLYQYKVKWVQRGYKTPLIDKLVFKKVAKLMGGKVRIIMSGGAPLSADTHEQIKTCLCLELIQGYGLTETTSGATVMDYRDMTYGRTGGPLTVCDIRLVNWEEGNYRVTNKPYPQGEVLIGGECVSQGYYKLPGKTNEDFFEEDGQRWFKTGDIGEIQADGVLKIIDRKKDLVKLQAGEYVSLGKVESELKTCGIIENICVYGDPTKQYTVALVVPNQNHLEELAQKHGLGDKSFEELCSSPIIEKAILKEIAEHARKCKLQKYEVPAAITLCKEVWSPDMGLVTAAFKLKRKDIQDRYQHDINRMYAS
InterPro domains: - IPR042099: ANL, N-terminal domain (homologous_superfamily) [94-587]
- IPR000873: AMP-dependent synthetase/ligase domain (domain) [138-549]
- IPR020845: AMP-binding, conserved site (conserved_site) [294-305]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [589-726]
Interaction partners: - Fatty acid synthase
- carnitine O-palmitoyltransferase
- Lysosomal thioesterase PPT2 homolog
- Long-chain-fatty-acid--CoA ligase heimdall
- Very long-chain-fatty-acid--CoA ligase bubblegum
- Fatty acid synthase
- Long-chain-fatty-acid--CoA ligase
- Palmitoyl-protein thioesterase 1
- Fatty acid synthase
- Beta-alanine-activating enzyme
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0015645 (fatty acid ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0004467 (long-chain fatty acid-CoA ligase activity), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0007267 (cell-cell signaling), GO:0048856 (anatomical structure development), GO:1905954 (positive regulation of lipid localization), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0032879 (regulation of localization), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0007154 (cell communication), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0099536 (synaptic signaling), GO:0003002 (regionalization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:1905952 (regulation of lipid localization), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0010883 (regulation of lipid storage), GO:0010884 (positive regulation of lipid storage), GO:0006935 (chemotaxis), GO:0022008 (neurogenesis), GO:0035282 (segmentation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0010889 (regulation of sequestering of triglyceride), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0099537 (trans-synaptic signaling), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0098916 (anterograde trans-synaptic signaling), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007268 (chemical synaptic transmission), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030424 (axon)