Protein: T-cell leukemia/lymphoma protein 1B (Oncogene TCL-1B) (Oncogene TCL1B) (SYN-1) (Syncytiotrophoblast-specific protein) (TCL1/MTCP1-like protein 1) (O95988)
Organism: Homo sapiens (Human)
Function: Enhances the phosphorylation and activation of AKT1 and AKT2.
Sequence: MASEASVRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWARASQGSRYEPSITVHLWQMAVHTRELLSSGQMPFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQPERKD
InterPro domains: - IPR004832: TCL1/MTCP1 (family) [1-126]
- IPR036672: TCL1/MTCP1 superfamily (homologous_superfamily) [2-128]
Interaction partners: - RAC-alpha serine/threonine-protein kinase
- RAC-beta serine/threonine-protein kinase
- T-cell leukemia/lymphoma protein 1A
- RAC-gamma serine/threonine-protein kinase
- Protein p13 MTCP-1
- Mediator of RNA polymerase II transcription subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0019209 (kinase activator activity), GO:0019900 (kinase binding), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity), GO:0019901 (protein kinase binding), GO:0043539 (protein serine/threonine kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010941 (regulation of cell death), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:1903312 (negative regulation of mRNA metabolic process), GO:0043484 (regulation of RNA splicing), GO:0033119 (negative regulation of RNA splicing), GO:1903311 (regulation of mRNA metabolic process), GO:0048025 (negative regulation of mRNA splicing, via spliceosome), GO:0050684 (regulation of mRNA processing), GO:0050686 (negative regulation of mRNA processing), GO:0048024 (regulation of mRNA splicing, via spliceosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)