Protein: HECT-type E3 ubiquitin transferase (A0A8M3AW15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MAPQGRDHLATRESAGRRRSPNVRHTLSPENLRSLAERGGAEQAGVGLLRANSDTDLVSSQGRSSLTASTLEFTLCRGQNLVISWDIKEEVDATDWIGLYHIDETCPSNVWDCKNRGVNGTQCGQIVWRLEVGPYFLESETRICFKYYHGVSGALRATTPCITVKNPRASVDGQGEGQQASDSSRKLVSFTLSDIRAVGLKKGMFFNPDPYLKMSIHPGKRSCFPTFSHHGQERRSGITTNTTNPVWHGEKHTFVALMTDVLVIEVKDKFAKSRPIIKRFLGQLNIPVQLLLERHSTGNQSLSFSLCRRLPTDHVSGQMHFKVDVTSMGPDDVSPETILGAAALNGAPGTPSDDEELPHPLPISSAGPSPTASLGSNRNGEGSSIPSPDTEIYGGTLDDEAPSSPDLLQGSFSEQLDAIEAPKGPGDRPLGAASPKLRSSFPTHTRLSAMLHIDSDEDEDRSAATEATLSTFNGIPRSYQTPPKAAARGAVFDGGIEEPSEEAGLESEVETLNAGEEVPPEPEVVPSSVAPEVETASLMERQEEQGREVEVEEEEEEGLARSEELATEVDISSMASDCCPGPASASQEAEQGAEAAIDPGGEDLSDDPPTTYEVAETAEETHLTNEPEREAPKPEPPTNEEEECEDVTEDTMSRRWSLEATAGVSQEDEDELIPSGDGESVDSETFVTETESELGVPQVNGDQRVNSLPSVRQDIHRYQRVDEPLPPNWEARIDSHGRIFFVDHVNRTTTWQRPTGPPAPQGLTRSSSILQMEQLNRRYQSIRRTMTSERSEEPRVEDPPADETDVLAQSISEYRRDGIIGQSSSRSRLALLLQSPGAKFLSSPDFFSVLHSNPSAYRMFTSNTCLKHMISKVRRDAQHFERYQHNRDLVNFLNLFSNKQLELPRGWEMKHDHTGKAFFVDHNCRATTFIDPRLPLQNSRSSGLLAHRQHLSRQRSHSAGEVGDDSRSPSPPVQGRSSRNSQYQDLVPVAYNDKIVAFLRQPNIFEILQERQPELVRNHSLREKVQFIRNEGATGLTRLSSDADLVMLLSLFEEEVMSYVPPNALLLSSYCHASPQSSPGTPRANARAPAPYKRDFEAKLRNFYRKMETKGYGQGPGKVKLIIRRDHLLEDAFNQIMCYSRKDLQRSRLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDNDIEDMLDLTFTVNEEVFGQITERELKPGGSGIAVSDKNKKEYIERMVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSMLYEKMVTAVEETSTFGLE
InterPro domains: - IPR040524: E3 ubiquitin-protein ligase HECW1, helical box domain (domain) [832-896]
- IPR000569: HECT domain (domain) [1120-1475]
- IPR036020: WW domain superfamily (homologous_superfamily) [722-935]
- IPR035983: HECT, E3 ligase catalytic domain (homologous_superfamily) [1108-1469]
- IPR032348: E3 ubiquitin-protein ligase HECW1/2, N-terminal (domain) [50-168]
- IPR037795: E3 ubiquitin-protein ligase HECW, C2 domain (domain) [188-323]
- IPR001202: WW domain (domain) [723-934]
- IPR000008: C2 domain (domain) [171-302]
- IPR050409: E3 ubiquitin-protein ligase (family) [229-1473]
- IPR035892: C2 domain superfamily (homologous_superfamily) [189-336]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)