Protein: Histone RNA hairpin-binding protein (Histone stem-loop-binding protein) (P97440)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (By similarity). Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity). Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18036581}. Nucleus {ECO:0000269|PubMed:18036581}. Note=Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor (By similarity). Polyribosome-associated. {ECO:0000250|UniProtKB:Q14493}.
Sequence: MACRPRSPPGYGSRRDGGASPRSPARWSLGRKRRADGRDRKPEDSEEGELQTADHRPESFTTPEGHKPRSRCSDWASAVEEDEMRTRVNKEIARYKRKLLINDFGRERKSSSGSSDSKESMSSVPADVETDESVLMRRQKQINYGKNTIAYDRYIKEVPRHLRQPGIHPRTPNKFKKYSRRSWDQQIKLWKVALHFWDPPAEEGCDLQEIQPVDLGEMETEFTESSSESQTSSQDNFDVYAGTPTKVRHVDCQVEDEFDLEACLTEPLKDFSAMS
InterPro domains: - IPR038294: SLBP, RNA-binding domain superfamily (homologous_superfamily) [127-199]
- IPR026502: Histone RNA stem-loop-binding protein SLBP1/SLBP2 (family) [11-269]
- IPR029344: Histone RNA hairpin-binding protein, RNA-binding domain (domain) [130-199]
Interaction partners: - 3'-5' exoribonuclease 1
- U7 snRNA-associated Sm-like protein LSm11
- MIF4G domain-containing protein
- Eukaryotic translation initiation factor 4E
- U7 snRNA-associated Sm-like protein LSm10
- Nuclear cap-binding protein subunit 1
- Heterogeneous nuclear ribonucleoprotein Q
- Y-box-binding protein 1
- Small nuclear ribonucleoprotein-associated protein B
- Regulator of nonsense transcripts 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0044092 (negative regulation of molecular function), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0051726 (regulation of cell cycle), GO:1901360 (organic cyclic compound metabolic process), GO:0046907 (intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0043086 (negative regulation of catalytic activity), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0072594 (establishment of protein localization to organelle), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0006886 (intracellular protein transport), GO:0090304 (nucleic acid metabolic process), GO:0015031 (protein transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0006259 (DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0051338 (regulation of transferase activity), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051276 (chromosome organization), GO:0019220 (regulation of phosphate metabolic process), GO:0042254 (ribosome biogenesis), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0034504 (protein localization to nucleus), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045859 (regulation of protein kinase activity), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0051168 (nuclear export), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)