Protein: Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) (P43220)
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19861722, ECO:0000269|PubMed:26308095, ECO:0000269|PubMed:27196125, ECO:0000269|PubMed:28514449, ECO:0000269|PubMed:7517895, ECO:0000269|PubMed:8216285, ECO:0000269|PubMed:8405712}; Multi-pass membrane protein {ECO:0000269|PubMed:28514449}.
Sequence: MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
InterPro domains: - IPR050332: G-protein coupled receptor 2 (family) [32-439]
- IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [45-135]
- IPR047033: Glucagon-like peptide-1 receptor, 7TM (domain) [141-419]
- IPR017983: GPCR, family 2, secretin-like, conserved site (conserved_site) [62-409]
- IPR000832: GPCR, family 2, secretin-like (family) [144-405]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [24-152]
- IPR003290: GPCR, family 2, glucagon-like peptide-1/glucagon receptor (family) [12-385]
- IPR017981: GPCR, family 2-like, 7TM (domain) [144-406]
- IPR003292: GPCR, family 2, glucagon-like peptide-1 receptor (family) [16-449]
Interaction partners: - Pro-glucagon
- Gastric inhibitory polypeptide
- Guanine nucleotide-binding protein G
- VIP peptides
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
- Dipeptidyl peptidase 4
- Pituitary adenylate cyclase-activating polypeptide
- Natriuretic peptides A
- Glucagon-like peptide 2 receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0050794 (regulation of cellular process), GO:0048771 (tissue remodeling), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0035556 (intracellular signal transduction), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0098660 (inorganic ion transmembrane transport), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0008284 (positive regulation of cell population proliferation), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0050678 (regulation of epithelial cell proliferation), GO:0019932 (second-messenger-mediated signaling), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0048193 (Golgi vesicle transport), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0019722 (calcium-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)