Protein: UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I) (Q9BZM6)
Organism: Homo sapiens (Human)
Function: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12782710}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12782710}. Endoplasmic reticulum {ECO:0000269|PubMed:12782710}. Note=In CMV-infected fibroblasts, detected in the endoplasmic reticulum/cis-Golgi. {ECO:0000269|PubMed:12782710}.
Sequence: MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAPGTTQPKAMATTLSPWSLLIIFLCFILAGR
InterPro domains: - IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [27-203]
- IPR011161: MHC class I-like antigen recognition-like (domain) [39-203]
- IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [29-204]
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [20-231]
Interaction partners: - NKG2-D type II integral membrane protein
- MHC class I polypeptide-related sequence B
- UL16-binding protein 3
- Hematopoietic cell signal transducer
- UL16-binding protein 2
- CD226 antigen
- Natural cytotoxicity triggering receptor 1
- Natural cytotoxicity triggering receptor 3
- MHC class I polypeptide-related sequence A
- Leukocyte immunoglobulin-like receptor subfamily B member 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0001906 (cell killing), GO:0009605 (response to external stimulus), GO:0002252 (immune effector process), GO:0001775 (cell activation), GO:0006950 (response to stress), GO:0045321 (leukocyte activation), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0051707 (response to other organism), GO:0006952 (defense response), GO:0002443 (leukocyte mediated immunity), GO:0043207 (response to external biotic stimulus), GO:0001909 (leukocyte mediated cytotoxicity), GO:0046649 (lymphocyte activation), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0002449 (lymphocyte mediated immunity), GO:0002228 (natural killer cell mediated immunity), GO:0030101 (natural killer cell activation), GO:0042267 (natural killer cell mediated cytotoxicity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)