Protein: Prephenate dehydratase (PDT) (EC 4.2.1.51) (P9WIC3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MVRIAYLGPEGTFTEAALVRMVAAGLVPETGPDALQRMPVESAPAALAAVRDGGADYACVPIENSIDGSVLPTLDSLAIGVRLQVFAETTLDVTFSIVVKPGRNAADVRTLAAFPVAAAQVRQWLAAHLPAADLRPAYSNADAARQVADGLVDAAVTSPLAAARWGLAALADGVVDESNARTRFVLVGRPGPPPARTGADRTSAVLRIDNQPGALVAALAEFGIRGIDLTRIESRPTRTELGTYLFFVDCVGHIDDEAVAEALKAVHRRCADVRYLGSWPTGPAAGAQPPLVDEASRWLARLRAGKPEQTLVRPDDQGAQA
InterPro domains: - IPR018528: Prephenate dehydratase, conserved site (conserved_site) [229-236]
- IPR002912: ACT domain (domain) [203-280]
- IPR008242: Bifunctional P-protein, chorismate mutase/prephenate dehydratase (family) [1-283]
- IPR045865: ACT-like domain (homologous_superfamily) [184-281]
- IPR001086: Prephenate dehydratase (domain) [3-190]
Interaction partners: - Prephenate dehydrogenase
- Intracellular chorismate mutase
- Secreted chorismate mutase
- Aromatic amino acid aminotransferase
- Histidinol-phosphate aminotransferase
- Histidinol-phosphate aminotransferase Rv2231c
- Probable phosphoglycerate mutase
- Chorismate synthase
- Catalase-peroxidase
- DUF2470 domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009072 (aromatic amino acid metabolic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009073 (aromatic amino acid family biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0006558 (L-phenylalanine metabolic process), GO:1902221 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process), GO:0009095 (aromatic amino acid family biosynthetic process, prephenate pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)