Protein: Ribokinase (RK) (EC 2.7.1.15) (P25332)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03215, ECO:0000269|PubMed:14562095}.
Sequence: MGITVIGSLNYDLDTFTDRLPNAGETFRANHFETHAGGKGLNQAAAIGKLKNPSSRYSVRMIGNVGNDTFGKQLKDTLSDCGVDITHVGTYEGINTGTATILIEEKAGGQNRILIVEGANSKTIYDPKQLCEIFPEGKEEEEYVVFQHEIPDPLSIIKWIHANRPNFQIVYNPSPFKAMPKKDWELVDLLVVNEIEGLQIVESVFDNELVEEIREKIKDDFLGEYRKICELLYEKLMNRKKRGIVVMTLGSRGVLFCSHESPEVQFLPAIQNVSVVDTTGAGDTFLGGLVTQLYQGETLSTAIKFSTLASSLTIQRKGAAESMPLYKDVQKDA
InterPro domains: - IPR011611: Carbohydrate kinase PfkB (domain) [3-324]
- IPR029056: Ribokinase-like (homologous_superfamily) [1-333]
- IPR011877: Ribokinase (family) [1-331]
- IPR002173: Carbohydrate/purine kinase, PfkB, conserved site (conserved_site) [277-290]
- IPR002139: Ribokinase/fructokinase (family) [5-256]
Interaction partners: - Transketolase 1
- Transketolase 2
- Ribose-5-phosphate isomerase
- Phosphoribomutase
- Phosphoglucomutase 1
- Ribose-phosphate pyrophosphokinase 2
- Ribose-phosphate pyrophosphokinase 4
- Ribose-phosphate pyrophosphokinase 5
- Ribose-phosphate pyrophosphokinase 3
- Ribose-phosphate pyrophosphokinase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0019200 (carbohydrate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0016054 (organic acid catabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:0043436 (oxoacid metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)