Protein: Origin recognition complex subunit 5 (Origin recognition complex 53 kDa subunit) (P50874)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication. This subunit is a candidate for the mediation of ATP-dependent binding of ORC to origins. May also be a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-ORC5).
Subcellular location: Nucleus.
Sequence: MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYFNANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQVEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYIKLNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTILVMSRCGELMEDSCLRKRIIEEQITDCTDDQFQNVAANFIHLIVQAFHSYTGNDIFALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLSENGQGESAITTNRDDLENSQTYDLSIISKYLLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPSLFAIERLLAIFQAIFPIQGKAESGSLSALREESLMKANIEVFQNLSELHTLKLIATTMNKNIDYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIHE
InterPro domains: - IPR047088: Origin recognition complex subunit 5, C-terminal (domain) [324-474]
- IPR048866: ORC5, lid domain (domain) [237-292]
- IPR020796: Origin recognition complex, subunit 5 (family) [5-476]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [7-202]
- IPR041664: Orc1-like, AAA ATPase domain (domain) [8-152]
Interaction partners: - ATP-dependent DNA helicase RRM3
- Origin recognition complex subunit 1
- Cell division cycle protein CDT1
- DNA replication licensing factor MCM6
- Origin recognition complex subunit 2
- Origin recognition complex subunit 4
- Cell division control protein 6
- DNA replication licensing factor MCM4
- Origin recognition complex subunit 6
- Nucleolar complex-associated protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0003688 (DNA replication origin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044786 (cell cycle DNA replication), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:1902292 (cell cycle DNA replication initiation), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:1902975 (mitotic DNA replication initiation), GO:1902315 (nuclear cell cycle DNA replication initiation), GO:0090304 (nucleic acid metabolic process), GO:0033260 (nuclear DNA replication), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0006260 (DNA replication), GO:0006270 (DNA replication initiation), GO:0051276 (chromosome organization), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0000808 (origin recognition complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0031261 (DNA replication preinitiation complex), GO:0043229 (intracellular organelle), GO:0005664 (nuclear origin of replication recognition complex), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0005656 (nuclear pre-replicative complex), GO:0036387 (pre-replicative complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome)