Protein: C-C chemokine receptor type 1 (C-C CKR-1) (CC-CKR-1) (CCR-1) (CCR1) (Macrophage inflammatory protein 1-alpha receptor) (MIP-1alpha-R) (RANTES-R) (CD antigen CD191) (P51675)
Organism: Mus musculus (Mouse)
Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P32246}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32246}.
Sequence: MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [51-301]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [36-309]
- IPR050119: C-C chemokine receptor type 1-9-like (family) [8-340]
- IPR000355: Chemokine receptor family (family) [24-317]
- IPR002236: CC chemokine receptor 1 (family) [2-329]
Interaction partners: - C-C motif chemokine 5
- C-C motif chemokine 9
- C-C motif chemokine 3
- C-C motif chemokine 7
- C-C motif chemokine 4
- C-C motif chemokine 2
- C-C motif chemokine 8
- C-C motif chemokine 6
- Eotaxin
- C-X-C motif chemokine 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0005515 (protein binding), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0019955 (cytokine binding), GO:0140375 (immune receptor activity), GO:0019956 (chemokine binding), GO:0004896 (cytokine receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0019957 (C-C chemokine binding), GO:0004950 (chemokine receptor activity), GO:0001637 (G protein-coupled chemoattractant receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009605 (response to external stimulus), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0042221 (response to chemical), GO:0051094 (positive regulation of developmental process), GO:0042330 (taxis), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0006935 (chemotaxis), GO:0008284 (positive regulation of cell population proliferation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0050678 (regulation of epithelial cell proliferation), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0001938 (positive regulation of endothelial cell proliferation), GO:0001936 (regulation of endothelial cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)