Protein: Ribosomal RNA processing protein 45 (EC 3.1.13.-) (Q583T6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MQYQRAALVIASPALTQREVEFTKSAWLAGLRPDQRTAQQMREVSVEFPLLSRDVVVVRCGGSVVTAAIATALVEPTPQRPKHGLLHFSVRRLHTERDSPAADGSTQKNLVAFLERLVRTGGVIDTAGLCVLPGQKVWSLTVDVTIMNDEGNCNDAAVWAVIALLMHHRRPELTVRGSSVIVHPPHEREPVPLSVQHTPLPFTFAITMAPTEREKALNHQRALSATGSSSGPQPSSGVGNSIDTASAFAIDGTSPQPLGVVVDPTTAESLAAASSIVVAINAEGQVCTVVKAEGCSIHLKDLNACIEAAGTLAPRVLDLIKVAMEAHDERRKTAMKGQFAWAQKRSGVGKVEQACVKKIKTET
InterPro domains: - IPR033100: Exosome complex component RRP45 (family) [15-319]
- IPR036345: Exoribonuclease, PH domain 2 superfamily (homologous_superfamily) [193-348]
- IPR050590: Exosome complex component Rrp42 subfamily (family) [14-327]
- IPR001247: Exoribonuclease, phosphorolytic domain 1 (domain) [41-171]
- IPR027408: PNPase/RNase PH domain superfamily (homologous_superfamily) [12-344]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [12-189]
- IPR015847: Exoribonuclease, phosphorolytic domain 2 (domain) [253-309]
Interaction partners: - Exosome component CSL4
- Ribosomal RNA-processing protein 43
- Ribosomal RNA processing protein 4
- Exosome complex exonuclease RRP40
- RNasePH-like protein exosome-associated protein 1 Rrp42 homologue
- ATP-dependent DEAD/H RNA helicase, putative
- PNO1 second type I KH domain-containing protein
- Elongation factor 1-alpha, putative
- Ribosomal RNA processing protein 6
- Exosome-associated protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004532 (exoribonuclease activity), GO:0004527 (exonuclease activity), GO:0008408 (3'-5' exonuclease activity), GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters), GO:0016796 (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0000175 (3'-5'-RNA exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process), GO:0000460 (maturation of 5.8S rRNA)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0000178 (exosome (RNase complex)), GO:1905354 (exoribonuclease complex)