Protein: Glycogen synthase kinase-3 beta (EC 2.7.11.26) (Q9YH60)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MSGRPRTTSFAESCKPVPQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGDKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELREPNVKLPNGREKPSLFNFTTQELSSNPTLASILIPAHARNQAGASTPTNPSATSDANSGDRSQTTTAASASASNTST
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [55-378]
- IPR050591: Glycogen Synthase Kinase-3 (family) [30-385]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [177-189]
- IPR039192: Glycogen synthase kinase 3, catalytic domain (domain) [51-343]
- IPR017441: Protein kinase, ATP binding site (binding_site) [62-86]
- IPR000719: Protein kinase domain (domain) [56-340]
Interaction partners: - Axin-2
- Casein kinase I isoform alpha
- Catenin beta-1
- Axin-1
- G1/S-specific cyclin-D1
- Tuberin
- APC regulator of WNT-signaling pathway
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0048870 (cell motility), GO:0009653 (anatomical structure morphogenesis), GO:0007163 (establishment or maintenance of cell polarity), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0030011 (maintenance of cell polarity), GO:0009968 (negative regulation of signal transduction), GO:0048729 (tissue morphogenesis), GO:0032388 (positive regulation of intracellular transport), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0009799 (specification of symmetry), GO:0051130 (positive regulation of cellular component organization), GO:0031647 (regulation of protein stability), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0001525 (angiogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0051222 (positive regulation of protein transport), GO:0060562 (epithelial tube morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0001944 (vasculature development), GO:0070201 (regulation of establishment of protein localization), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0010468 (regulation of gene expression), GO:0048568 (embryonic organ development), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0072359 (circulatory system development), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0021532 (neural tube patterning), GO:0050708 (regulation of protein secretion), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0007507 (heart development), GO:0032386 (regulation of intracellular transport), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0090316 (positive regulation of intracellular protein transport), GO:0021915 (neural tube development), GO:0048562 (embryonic organ morphogenesis), GO:1904951 (positive regulation of establishment of protein localization), GO:0048562 (embryonic organ morphogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0060973 (cell migration involved in heart development), GO:0030111 (regulation of Wnt signaling pathway), GO:0032880 (regulation of protein localization), GO:0060485 (mesenchyme development), GO:0061053 (somite development), GO:1905477 (positive regulation of protein localization to membrane), GO:0036211 (protein modification process), GO:0009855 (determination of bilateral symmetry), GO:0022008 (neurogenesis), GO:0060914 (heart formation), GO:0048568 (embryonic organ development), GO:0051223 (regulation of protein transport), GO:0060972 (left/right pattern formation), GO:0031326 (regulation of cellular biosynthetic process), GO:0060606 (tube closure), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0050821 (protein stabilization), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0030182 (neuron differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0048925 (lateral line system development), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0018193 (peptidyl-amino acid modification), GO:0001947 (heart looping), GO:0007010 (cytoskeleton organization), GO:0043549 (regulation of kinase activity), GO:0048699 (generation of neurons), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0060028 (convergent extension involved in axis elongation), GO:0043009 (chordate embryonic development), GO:0042074 (cell migration involved in gastrulation), GO:0031399 (regulation of protein modification process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0060026 (convergent extension), GO:0001840 (neural plate development), GO:0048557 (embryonic digestive tract morphogenesis), GO:0014032 (neural crest cell development), GO:0045861 (negative regulation of proteolysis), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045859 (regulation of protein kinase activity), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018105 (peptidyl-serine phosphorylation), GO:0032446 (protein modification by small protein conjugation), GO:1903214 (regulation of protein targeting to mitochondrion), GO:0018209 (peptidyl-serine modification), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0046777 (protein autophosphorylation), GO:0031396 (regulation of protein ubiquitination), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0010799 (regulation of peptidyl-threonine phosphorylation), GO:0016567 (protein ubiquitination), GO:0006469 (negative regulation of protein kinase activity), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1990234 (transferase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex), GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)