Protein: Kinase suppressor of ras (Q8I0R4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSSNNNAPASAPDTGSTNANDPISGSLSVDSNLVIIQDMIDLSANHLEGLRTQCAISSTLTQQEIRCLESKLVRYFSELLLAKMRLNERIPANGLVPHTTGNELRQWLRVVGLSQGTLTACLARLTTLEQSLRLSDEEIRQLLADSPSQREEEELRRLTRAMQNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSVGNIGLGNNSTASPRTHHRQHGVKGKNSALANSTNFKSGRQSPSATEELNSTQGSQLTLTLTPSPPNSPFTPSSGLSSSLNGTPQRSRGTPPPARKHQTLLSQSHVQVDGEQLARNRLPTDPSPDSHSSTSSDIFVDPSTNASSGGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMKCTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLHQQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQPSQFNFPNVTVTSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVNSTTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLSGSASTDSDRTPVRVDSTEDGDSGQWRQNSISLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLLEHLPKKRLARSPSHPVNLSRSAESVF
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [660-940]
- IPR046349: C1-like domain superfamily (homologous_superfamily) [363-420]
- IPR046933: Kinase suppressor RAS 1, N-terminal helical hairpin superfamily (homologous_superfamily) [28-90]
- IPR046861: Kinase suppressor RAS 1, N-terminal helical hairpin (domain) [33-86]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [103-169]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [370-418]
- IPR025561: Kinase suppressor of RAS, SAM-like domain (domain) [92-166]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [681-939]
- IPR017441: Protein kinase, ATP binding site (binding_site) [685-705]
- IPR000719: Protein kinase domain (domain) [679-943]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [796-808]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [513-947]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030234 (enzyme regulator activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0035591 (signaling adaptor activity), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0019209 (kinase activator activity), GO:0019900 (kinase binding), GO:0005078 (MAP-kinase scaffold activity), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009791 (post-embryonic development), GO:0048584 (positive regulation of response to stimulus), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0009798 (axis specification), GO:0009887 (animal organ morphogenesis), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0009790 (embryo development), GO:0010647 (positive regulation of cell communication), GO:0035107 (appendage morphogenesis), GO:0009886 (post-embryonic animal morphogenesis), GO:0009880 (embryonic pattern specification), GO:0035282 (segmentation), GO:0048737 (imaginal disc-derived appendage development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0000578 (embryonic axis specification), GO:1902533 (positive regulation of intracellular signal transduction), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007350 (blastoderm segmentation), GO:0007444 (imaginal disc development), GO:0007351 (tripartite regional subdivision), GO:1902531 (regulation of intracellular signal transduction), GO:0009952 (anterior/posterior pattern specification), GO:0009948 (anterior/posterior axis specification), GO:0035220 (wing disc development), GO:0008595 (anterior/posterior axis specification, embryo), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0007472 (wing disc morphogenesis), GO:0051057 (positive regulation of small GTPase mediated signal transduction), GO:0046578 (regulation of Ras protein signal transduction), GO:0046579 (positive regulation of Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)