Protein: Homeobox protein PKNOX1 (A0A8N7TEV4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MMTSPSVSMEDYQEAEQMQVGEPTAGQVEERLEEEEEEEEEEERDEEEEDSGSAPSEPQTPMEVYKSAIYRHPLFPLLALLFEKCEQSTQSSECVTSASFDVDIENFVRNQEKEGKAFFSEDPDLDNLMVKAIQVLRIHLLELEKVNDLCKDFCSRYIACLKTKMNSETLLSGDPGSPYSPSPTQPQNPFTGAMSPQGIVVPASALQQGNVTVTAVNPTQMVTGGTVYQPVTVVTPQGQVVTQTLSPGTVRIQNSQLQLQLNQDLSFFSQEDGSSKAKRGILPKHATNVMRSWLFQHIGHPYPTEDEKKQIALQTNLTLLQVNNWFINARRRILQPMLDASSSDTPKSKKKTPQTRPLQRFWPNSLASSVSQQQVTMEDGTTVTVGVGEDGLQTLSSDGATLAMQQVMMGGHSEDDDDEDDEEDEDTDPSHSDMSRLGLETSDSL
InterPro domains: - IPR009057: Homedomain-like superfamily (homologous_superfamily) [275-343]
- IPR050224: Three Amino acid Loop Extension (TALE) homeobox (family) [102-368]
- IPR032453: Homeobox protein PKNOX/Meis, N-terminal (domain) [62-168]
- IPR001356: Homeodomain (domain) [273-340]
- IPR008422: KN homeodomain (domain) [293-332]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0009653 (anatomical structure morphogenesis), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0002262 (myeloid cell homeostasis), GO:0048522 (positive regulation of cellular process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0046649 (lymphocyte activation), GO:0048872 (homeostasis of number of cells), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0034101 (erythrocyte homeostasis), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0035239 (tube morphogenesis), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0007423 (sensory organ development), GO:0030099 (myeloid cell differentiation), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048514 (blood vessel morphogenesis), GO:0030218 (erythrocyte differentiation), GO:0072359 (circulatory system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0042110 (T cell activation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0001654 (eye development), GO:0030217 (T cell differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0150063 (visual system development), GO:1903131 (mononuclear cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0043010 (camera-type eye development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)