Protein: Cohesin subunit SA (F1QNA7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate
Subcellular location: Chromosome. Nucleus. Chromosome, centromere
Sequence: MITSELPVLQDTGDSGQDTVSLSMSMSELDDPGDGKIKKKRGRPGRPPAANKKPRKSPSEKGFMAVQRGRKANGISQQNGEGDPVTLFEVVKQGKSAMQSVVDDWIESYKQDRDLALLDLINFFIQCSGCKGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTISGPLWKKFRYNFCEFICVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINQDNTQRQYEAERSKIVGKRATEKLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQNLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILQGSEDALSNEDCENVYHLVYSAHRPVAVAAGEFLHRKLFSRHDPQAEEALAKRRGRSSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEVLADRQESSLIELTVCTIRQAAEAHPPVGRGTGKRVLTAKERKMQIDDKNKLTEHFIMALPMLLSKYQTDSEKVANLLQIPQYFDLDVYSAGRMEKHLDALLKQIKFVVEKHTDTEVLEACSKTYSILCSEEYTIMNRVDIARSQLIDELADRFNHSVEELLQAGEEADDDDIYNVLSTLKRLTAFHNAHDLTRWDFFGNCYRLLRTGIEQGSMPEQIAVQALQCSHYSILWQLVKITEGAPSKDDLLALRRVVKSFLAICQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLTTGSREGLQPLVFIPDGTLQNELLNFILDHVFIDQDDENQSIEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIIDMPAAADIFKHYMKYYNDYGDIIKETLSKTRQTDKILCAKTLILSLQQLFNELIQDQGPNLDRTSSHVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNPKGAEYPPPNLAFLEVLCEFSSKLLRQDKKTVHAYLEKFMTEQMMERREDIWLPLISYRNSLLTGGDEDRMSITSGSSSSKAGSIRSKKGRPPLHKKRIEEESMEGSWMMRNDSIQTPGGLQTPQLTSTVLRENPRQAAEHLPEQDTEPGSESDYVHNPQMQMSWLGQQKMEEVNRKERTAMSYIKARSGGVRQTVRGLMEDDAEPIFEDVMMSSRGQLEDMSEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAMIEDESGFTMPMF
InterPro domains: - IPR039662: Cohesin subunit Scc3/SA (family) [20-1127]
- IPR016024: Armadillo-type fold (homologous_superfamily) [179-837]
- IPR020839: Stromalin conservative domain (domain) [296-381]
- IPR013721: STAG (domain) [161-264]
- IPR056396: Cohesin subunit SCC3/SA, HEAT-repeats domain (domain) [483-747]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)