Protein: Testis-expressed protein 11 (Protein ZIP4 homolog) (ZIP4H) (Q8IYF3)
Organism: Homo sapiens (Human)
Function: Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
Subcellular location: Chromosome {ECO:0000250|UniProtKB:Q14AT2}. Note=Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes. {ECO:0000250|UniProtKB:Q14AT2}.
Sequence: MISAHCNLRLLCSSDSSASASQVAGTTEVVENLVTNDNSPNIPEAIDRLFSDIANINRESMAEITDIQIEEMAVNLWNWALTIGGGWLVNEEQKIRLHYVACKLLSMCEASFASEQSIQRLIMMNMRIGKEWLDAGNFLIADECFQAAVASLEQLYVKLIQRSSPEADLTMEKITVESDHFRVLSYQAESAVAQGDFQRASMCVLQCKDMLMRLPQMTSSLHHLCYNFGVETQKNNKYEESSFWLSQSYDIGKMDKKSTGPEMLAKVLRLLATNYLDWDDTKYYDKALNAVNLANKEHLSSPGLFLKMKILLKGETSNEELLEAVMEILHLDMPLDFCLNIAKLLMDHERESVGFHFLTIIHERFKSSENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAESMNWLHNILWRQAASSFEVQNYTDALQWYYYSLRFYSTDEMDLDFTKLQRNMACCYLNLQQLDKAKEAVAEAERHDPRNVFTQFYIFKIAVIEGNSERALQAIITLENILTDEESEDNDLVAERGSPTMLLSLAAQFALENGQQIVAEKALEYLAQHSEDQEQVLTAVKCLLRFLLPKIAEMPESEDKKKEMDRLLTCLNRAFVKLSQPFGEEALSLESRANEAQWFRKTAWNLAVQCDKDPVMMREFFILSYKMSQFCPSDQVILIARKTCLLMAVAVDLEQGRKASTAFEQTMFLSRALEEIQTCNDIHNFLKQTGTFSNDSCEKLLLLYEFEVRAKLNDPLLESFLESVWELPHLETKTFETIAIIAMEKPAHYPLIALKALKKALLLYKKEEPIDISQYSKCMHNLVNLSVPDGASNVELCPLEEVWGYFEDALSHISRTKDYPEMEILWLMVKSWNTGVLMFSRSKYASAEKWCGLALRFLNHLTSFKESYETQMNMLYSQLVEALSNNKGPVFHEHGYWSKSD
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [373-580]
- IPR013940: Meiosis specific protein Spo22/ZIP4/TEX11 (family) [190-445]
- IPR019734: Tetratricopeptide repeat (repeat) [417-490]
- IPR042861: Testis-expressed protein 11 (family) [12-931]
Interaction partners: - Synaptonemal complex protein 2
- Probable ATP-dependent DNA helicase HFM1
- Protein shortage in chiasmata 1 ortholog
- MutS protein homolog 4
- Protein SPO16 homolog
- Probable E3 SUMO-protein ligase RNF212
- MutS protein homolog 5
- Testis-expressed protein 15
- HORMA domain-containing protein 1
- Meiotic recombination protein SPO11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:2000241 (regulation of reproductive process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0009566 (fertilization), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:2000242 (negative regulation of reproductive process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:1903046 (meiotic cell cycle process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0012501 (programmed cell death), GO:0044085 (cellular component biogenesis), GO:0035234 (ectopic germ cell programmed cell death), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0045132 (meiotic chromosome segregation), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051026 (chiasma assembly), GO:0007131 (reciprocal meiotic recombination), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010623 (programmed cell death involved in cell development), GO:0016043 (cellular component organization), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0007060 (male meiosis chromosome segregation), GO:0044260 (cellular macromolecule metabolic process), GO:0007140 (male meiotic nuclear division), GO:0061458 (reproductive system development), GO:0000712 (resolution of meiotic recombination intermediates), GO:0098813 (nuclear chromosome segregation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0007127 (meiosis I), GO:0022607 (cellular component assembly), GO:0045143 (homologous chromosome segregation), GO:0007130 (synaptonemal complex assembly), GO:0090304 (nucleic acid metabolic process), GO:0006915 (apoptotic process), GO:0006259 (DNA metabolic process), GO:0007129 (homologous chromosome pairing at meiosis), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0048285 (organelle fission), GO:0006310 (DNA recombination), GO:0051276 (chromosome organization), GO:0008584 (male gonad development), GO:0000280 (nuclear division), GO:0035825 (homologous recombination), GO:0070193 (synaptonemal complex organization), GO:0035822 (gene conversion), GO:0140527 (reciprocal homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:2000241 (regulation of reproductive process), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)