Protein: Mitochondrial adenyl nucleotide antiporter SLC25A25 (Q8K3P6)
Organism: Rattus norvegicus (Rat)
Function: Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MLCLCLYVPIAGEAQTEFQYFESKGLPTELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIIGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCAKRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [29-177]
- IPR002067: Mitochondrial carrier protein (family) [189-406]
- IPR002167: Solute carrier family 25 member 16-like (family) [181-337]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [180-465]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [184-464]
- IPR002048: EF-hand domain (domain) [51-149]
Interaction partners: - NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 3
- NADH-ubiquinone oxidoreductase chain 4
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
- NADH-ubiquinone oxidoreductase chain 2
- NADH-ubiquinone oxidoreductase chain 5
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0010035 (response to inorganic substance), GO:0070887 (cellular response to chemical stimulus), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0051592 (response to calcium ion), GO:0098662 (inorganic cation transmembrane transport), GO:0071241 (cellular response to inorganic substance), GO:1902075 (cellular response to salt), GO:0071702 (organic substance transport), GO:1901701 (cellular response to oxygen-containing compound), GO:0006811 (monoatomic ion transport), GO:0071248 (cellular response to metal ion), GO:0006812 (monoatomic cation transport), GO:0071277 (cellular response to calcium ion), GO:0006816 (calcium ion transport), GO:0030001 (metal ion transport), GO:0070296 (sarcoplasmic reticulum calcium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)