Protein: Tapasin-related protein (TAPASIN-R) (TAP-binding protein-like) (TAP-binding protein-related protein) (TAPBP-R) (Tapasin-like) (Q9BX59)
Organism: Homo sapiens (Human)
Function: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
Subcellular location: Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein {ECO:0000269|PubMed:23401559}. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).
Sequence: MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLAKDGAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANMQVSGGGPSISLVMKTPRVTKNEALWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [198-300]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [191-395]
- IPR050380: Immune Recognition and Response Modulators (family) [48-406]
- IPR007110: Immunoglobulin-like domain (domain) [181-394]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [34-406]
- IPR003599: Immunoglobulin domain subtype (domain) [197-301]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [380-386]
- IPR003597: Immunoglobulin C1-set (domain) [316-392]
Interaction partners: - Beta-2-microglobulin
- Major histocompatibility complex class I-related protein 1
- HLA class I histocompatibility antigen, A alpha chain
- Vesicle-associated membrane protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0002683 (negative regulation of immune system process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0050777 (negative regulation of immune response), GO:0002696 (positive regulation of leukocyte activation), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0007162 (negative regulation of cell adhesion), GO:0008285 (negative regulation of cell population proliferation), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0050865 (regulation of cell activation), GO:0050867 (positive regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0051251 (positive regulation of lymphocyte activation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0070664 (negative regulation of leukocyte proliferation), GO:0070665 (positive regulation of leukocyte proliferation), GO:0022408 (negative regulation of cell-cell adhesion), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0051249 (regulation of lymphocyte activation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050670 (regulation of lymphocyte proliferation), GO:0050870 (positive regulation of T cell activation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:0050868 (negative regulation of T cell activation), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0042130 (negative regulation of T cell proliferation), GO:0042129 (regulation of T cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)