Protein: BRCA2 DNA repair-associated (A0A8M2B481)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MFENFFHQIDRELGPLNPDWFEELNERASRDEGSAESSKAGENESIKAPETSALASQLFSTPRIFKQRHFPQSPDSIPNEKSQNEGANGELSAFPWTESSPCLFGSAKDSPKFDRSSEKPRDCFGLLDTPKRSLARSAKQISESLGAQINPDLSWTSSFNTPPSMTPTVILPTTEDRVASASILKDKESIFVRKLFPSLSKDSENATTLKQDVVTKSESIEADDLGEKTVCSPNESLDISSLWKQRVPNAIEDGDVRNTVQNVLDGAEDVLSIFFSNNTSALRKIKSKERIRKRITNSSEDVKSVFLTSEPEQKLKADTETKSPSKNDDSIEWTPLSLSETILTEGCSSTSLVDNNNTVAPSETNDGAIFKFTSESSQTCPQSVRLESSPEGTQCQKILLDKSSAFMLNKKPRKFVYQVSSSEMSTTLTGSKADLPKCLDQTLKEGPSVEELSVCLNKSSFTNENPIGDQTQPQAVEQLSSEHLDHGLDMTQLSKAFAEEFTQEIMAGGLLDMPVQSNQKVQVQPKAEPESKNKDGNHTDISNLADISVNSPNKSTSITTFEISHDSGCPTTFSDLDRTTASFADIGEYFPTFKTANNKFICIPTEAIVKAKASLDEAAGDGLAKTSNQTKPKHFHVTETMCKSVSRSIPAPRPPVGQSIPSNHASGVSVSDASKTDSPKGFKMNFSNCSLPQSDESDCKTSSKTIITVSDAGLQTESLLKEKLGRSSESSKPIHQKVDFERSAERHAVFDISSTQKPTAVDSSCDDLEENGTLTASQKADVTELCSLLEEANSQYEFTQYKSTNIGSHNRTTEKEWDPDILNDIDFDDSFSCDVVKGKHPSKTNASSVNTSDLISFRSDLKEKQNGTVVLSVTEESALVDGMRSILSKSSDNSHFHTFGFKTAKGKAISVSEKSLNKAKHFFEEDYKEATFTGVINQEHFKTESSVKTCISTENNNAQTKQDVRLSCGEVNAAHNMINWQEAGNAGTEPNCLRDKTDVVCVDSNIHFGFSTARGAKLKVSEKALEQARMFLNDVDSIGESQTPKLVPRSSGKHDVSMQSTRLQKTKDLCRGETSIKISQPDSGVANQISNGADITTFNSENVFQEQKSGNAAKEVCEKISPSETSMPQPQQGYGFQTASGKGVSVLPSALKKAKAIFKDCDSNIDNLQSTNMEERKTKLDVEIVKQTNALISNSKSVTFSDVEEFKTDLINNLDQEAPQKEVCELKGLQSEFSNLISSNGNCGFSTASGKKVSVSAEALQRAKDVLFESVDGFSCANVYKKTNQVVDIQLDSSSSGKHKGFCTAGGKKVAFSATGLQKAKNLFRGCEEESLTTEQNCKGLSNVLMLACNGVSLIPEPGNSSGNNVGFSTAGGRKMDISVTALQKANNLFKDCEEESLASRSLAHQGFTTASGKNVFVSEKALSEVRAVFAGCDETSFSLELKKLSVNNVGFSTAGGKKVTISDTSLQRTMNLFQDCEEESLGSRSLKHQGCKGFTTASGKNVTVSEKALSEVRAVFAGCDEASFSHEPKNISGNKIGFSTTVEKMTTALEMPNNNNNFKDCEEESLASRNLMHQACKGFTTASGKNVTVSETALNEVKAVFAGCDEATFDLEPKKSLGSNIGFSTAGGKKVTISSTALQRAQTLFKDCEEEKEVFESEKAPLPTKSFHARSEDIVDGNLKFDQTNKKNPRLSTASGKVVSVTKVSLEETSTFFREFDNQNTATDNQLLLRDSSKHYPQHKDRQTKATLHPKAARNEPAHLDLHSLDFNSCTDTQQIYFEQEAMACTKALLEDDDLIESAGLISSEDIDNKRRPSFSDVQTIESVDQNRKRKRQVDGSSVADSGQPPLKRQLLSEFDRTLHAKTSGLTPLKSCPNGTLKDRRVFKYNVHLKPYVTSPVLFPVNQQSNNIEEHCSTESVQKRCNSDHMGGVFNPPFQKNMNPPTSNSQDASKVSSGIVLSFNVVNQEENPNSKEMDQIMAISKSHCDRGKQNCNEKNQDSKSKSSSSVQSIPLKIGNFDEKDMIALQESLQLARDMQDMRLRKKKRQTIRPVPGSLYLAKTSGVSRKSLRDAVGCTCPSQYTQDELSQHGVHHKVLEITSENAESFRFDCSDYFTCEHLMESGALQLADGGWLVPDSKGTVGKEEFFSALCDTPGVDPKLISDVWVFNHYRWIIWKRASMERTFPNLIGGLCLTPEQVLLQLKFRYDVEVDHSQRSALRRIMERDDTPAKTLVLCVCGIVQTCQNPEKTMKDDKSPSAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIGDKIVTSGAELVGSQEACPPLEAPESLMLKISANSTRRARWDTKLGYYRDPRPIRLLLSSLYASGGLVSCVNLLVLRSYPTQWMEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQFEKEMEGKKKKRAQRRTFSRHEIETLQDGDELYEAMEQDAAVETRLSHKQMEAVSKYRCCREEKRQAELQERVQKAVMEAQEAEGGCPNRDVTPVWKLSVIDASDMQSNCVYTLNIWRPTRELQGLLTEGHRYRAYHLASSEGKKRSGVAHIQLTATKKTLFQDIEVSPEWLHQHFRARECVRFRELQNPHFSSPCGEVDIVGYIVSIEGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQVRVLSGPVPSLYAGEQALFSINPKESYLQEAMAHLKTFAQNYEQFFNLAEEKVSDVVPSGVLGSFQSPRTPGVQPFPKMNGTVTPQQKSSIFSPFTPLNRRTPASTSNSEVKDSKNLKRRRGLDYLSRIPSPPPLIPLKTRASPCINKTFNPPRKSVTPKPPQNECSPASRPPAGEEKWVHDEELAMIDTQALVDGLMND
InterPro domains: - IPR015252: Breast cancer type 2 susceptibility protein, helical domain (domain) [2027-2212]
- IPR015525: Breast cancer type 2 susceptibility protein (family) [10-2872]
- IPR055077: BRCA2, TR2 domain (domain) [2786-2833]
- IPR002093: BRCA2 repeat (repeat) [894-1719]
- IPR036315: BRCA2 helical domain superfamily (homologous_superfamily) [2022-2213]
- IPR015188: BRCA2, OB3 (domain) [2596-2731]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [2214-2735]
- IPR048262: BRCA2, OB2 domain (domain) [2350-2597]
- IPR015205: Tower domain (domain) [2376-2417]
- IPR015187: BRCA2, OB1 (domain) [2215-2341]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0035295 (tube development), GO:1901360 (organic cyclic compound metabolic process), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0070727 (cellular macromolecule localization), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0035239 (tube morphogenesis), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0048514 (blood vessel morphogenesis), GO:0090304 (nucleic acid metabolic process), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0006259 (DNA metabolic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0016331 (morphogenesis of embryonic epithelium), GO:0009792 (embryo development ending in birth or egg hatching), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0043009 (chordate embryonic development), GO:0033365 (protein localization to organelle), GO:0006310 (DNA recombination), GO:0034502 (protein localization to chromosome), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0000725 (recombinational repair), GO:0006302 (double-strand break repair), GO:0000724 (double-strand break repair via homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)