Protein: AP-1 complex subunit gamma (A0A140VJE7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00029433}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029433}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00029433}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Sequence: MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPSSAGGELLDLLGDINLTGAPAAAPAPASVPQISQPPFLLDGLSSQPLFNDIAAGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [22-602]
- IPR050840: Adaptor Complexes Large Subunit (family) [8-812]
- IPR013041: Clathrin adaptor, appendage, Ig-like subdomain superfamily (homologous_superfamily) [698-824]
- IPR017107: Adaptor protein complex AP-1, gamma subunit (family) [3-823]
- IPR008152: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (domain) [702-820]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1-591]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [23-576]
- IPR008153: Gamma-adaptin ear (GAE) domain (domain) [705-820]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0030742 (GTP-dependent protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019894 (kinesin binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0033059 (cellular pigmentation), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0021700 (developmental maturation), GO:0048066 (developmental pigmentation), GO:0043476 (pigment accumulation), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0031343 (positive regulation of cell killing), GO:0051649 (establishment of localization in cell), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0002694 (regulation of leukocyte activation), GO:0050867 (positive regulation of cell activation), GO:0031341 (regulation of cell killing), GO:0002696 (positive regulation of leukocyte activation), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0046907 (intracellular transport), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0006810 (transport), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0050931 (pigment cell differentiation), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0048753 (pigment granule organization), GO:0050865 (regulation of cell activation), GO:1903532 (positive regulation of secretion by cell), GO:0043300 (regulation of leukocyte degranulation), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0032438 (melanosome organization), GO:0043302 (positive regulation of leukocyte degranulation), GO:0017157 (regulation of exocytosis), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0045921 (positive regulation of exocytosis), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0051251 (positive regulation of lymphocyte activation), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0016482 (cytosolic transport), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0051249 (regulation of lymphocyte activation), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity), GO:0002717 (positive regulation of natural killer cell mediated immunity), GO:0016050 (vesicle organization), GO:0032816 (positive regulation of natural killer cell activation), GO:0048193 (Golgi vesicle transport), GO:0032814 (regulation of natural killer cell activation), GO:0006896 (Golgi to vacuole transport), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:1903307 (positive regulation of regulated secretory pathway), GO:0007041 (lysosomal transport), GO:1903305 (regulation of regulated secretory pathway), GO:0002715 (regulation of natural killer cell mediated immunity), GO:0006892 (post-Golgi vesicle-mediated transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0098791 (Golgi apparatus subcompartment), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0043227 (membrane-bounded organelle), GO:0055037 (recycling endosome), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0032588 (trans-Golgi network membrane), GO:0012506 (vesicle membrane), GO:0005802 (trans-Golgi network), GO:0030135 (coated vesicle), GO:0005774 (vacuolar membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0030136 (clathrin-coated vesicle), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)