Protein: Dendrin (P50617)
Organism: Rattus norvegicus (Rat)
Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein.
Subcellular location: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus {ECO:0000250}. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.
Sequence: MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAASRQSMDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPELRNALRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGREGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPCLEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREFEAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQTEEGLVREDTRKTPQGKRE
InterPro domains: - IPR026500: Dendrin (family) [1-707]
Interaction partners: - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
- Synaptopodin
- Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
- Nucleoplasmin-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0035556 (intracellular signal transduction), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0048017 (inositol lipid-mediated signaling), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048015 (phosphatidylinositol-mediated signaling), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0014065 (phosphatidylinositol 3-kinase signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)