Protein: Rho guanine nucleotide exchange factor 3, isoform L (Q9W0S2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MATETFLDLNYERGKVSKRSLRPKLLKLTDVTIPHRSRKKNKVKTKDRSATSVRDRIYDDPAYTEDISHLANPMRRSSISGKSFLEHKTRSDTGGQASSSSLLAKNQLPQELHQYVSGKQAKIKQHHTATIASGSTAISINYECDSSSTDNEVQEPIQTKGGMNRRVRSLERNLAATGSERAEKKGTQKRTSKQKRNLSLDNNRHQPAGHPKREAVAVAKVGHDADTRARKERNRKPYGEMGPDGGVPTEVSELDDGYSARGSAQSSACTLPAESAADAAKVAIGKRFLRGEIGIKSFNYYLLKEGLKSSKKLVDQQRTPAGSGSVESPLKAEKRHCRSEENIYEEIFFKDTANAVSSSATGVATGMAMPVALTMCDQETHSLEKGAQPHGIGATNPAFADCEFCMEQCSKENCEYCLAHVEQVASKKLKAGQTQEEQYLNQGHRKNHTMDSRPSAPVVEVPTAHILEFQSYNPNNPGVYKIETTPVAITGDYNPILQFQQSSATTSTSATTTPSEPQIYGGYYLPHANQRPYHSPTVNSQLPNHYAVGGSLLLAQVTGATQGSATPPRRPQQHFIVGYQNGGGMSAGAASLQRFNTKSSSSSDSLPYHKYNTMARLEANVLAAPATGDLYYAVSGTQPLHPLMYAANRPIGGSQILVDPYDPQMYKSDSKASILSEFSLRSSDNSQRYARHPHRRHGGRVSDSSLFSVYSNSGQRRYFGSSEGRFGYDCRRCSLDGVIGMSTATGGSMMAPDKCSYSDNCRFECRNCDCSSNYFSSDFDDVYGSIARGGSSGIPRKTAAGTLPSSAQDDQVERLEAPPASMEQQQYADLKQNKYAQDFFKHVNDVKRSIYQSEMKRNNSLESSRSGPRAGGSTKSNVKASPKRAASQETRLVTTLPLSRSRLSAGVKPTPAPRTSLQTPTPLPETTVAKDPTPSKRKSQPTVRREYPSLDRLVASTTGTIPKKNSRNITAASLQSPKLTQKTRSEAPEKKVAPEDQLPLPPSGKRHHRTGASKTNTNAPCSSLRRKDIPAPPPPSPATYSDLQELKANMEGFRDDTKSRSLEYDTNDLTADDNSNKTQKKSLSGPPNPMTEAPIGATDAGAVETDDNDVFYDARSEDSGGGILPSNTSDISKMSPSHMATFTRAATNENRKGAFDNEKEHSAEDDDSPSPAAPAPEGREQASSITGRPKGNGNSKITTTPSCELGSSAEAESKLDSAALCRPRPRPRQASPHLPPECTDTGGAGDEQASKTKHEKKTPADAPRQHVGPTCSEGQRTAALATNVACALSTTTNAGNTSASNSVLELELSCKTGNTDSETPAVAHSDPTSDVPACGTAENPTHLRALTRQDYACIDSSEAQSDDSHLTRDSITRESQNDELSSSTLEKLDVSTLPLPALPKRRRTRSRTSPSKHRQQQQQQQQQQQQRHEVIEDANAVDASTAAAGQQHPKPRQGAASPESQKPEISGAKNNAAGEQQKQPQSQQQQTHLSAFQQYVAKRRESLEASNRCFNEKLEARRMHYHMGGSAANGNATASHLTAGSNGVPTYLFGENFYGVPATGRKSISPTTKKEEIFLNKSGWVQVNTTRGVNKDDNGGGYRSLSYAQQNGGGRVAAMLTDPGRRSDLARKSFILQHQQQHQSNISMTEPKFVGSKVEELIQRNEARLSGCSIRYPSLRPGHRIIDPQLANILNERPGFLPVKGPTDLDSPLTPILSPPPAFQDNSRSARRQERRNPGRQQGPLPLPVPFRSEPQMDPQNPINGSAKGMVFSRSFEYDTRRHTPTDNYVETFSRSFDGNLSDRLLNLAVLAGQRERSPNFSTLTGNSPNYLTKRESGGGSSGSLRSRDSSPKYLHPQATTAYLNAAVKEAPPVYSVPTGSQAKYSPRSRFERTTERSKTHALGRSRKSQFSRVGSAGPLIAHPNTANVGVSRFRSFDTSKSQRLNSCDSGARSDLSNDELDNEDGGLNDFLSAGSHKFPKIGTSSVSVSPFKMQRQRSLTPDRNDSHSSTSSLRKQRSNTPESRSLTPEERRKKGSQLSLGGARQSSSSRSNTFEGRQRHDDKTPPNISRSSSSSSYSGGESHEPLNGTGSTTVTPSAGSGSTSHRRALTAKQAEQEHRIRRSRSLQLTERSPNRAHKSIVNVGALVPQQRSVGVPYQQSRVPGGGVFPPTIRTSPAGAKIHVNSPAPPNSSVRVRHNETDKARSFDFDYNNFSRGGGAKGSSRTAHTSGSGGDSGSNQNLRVERESRSFDDEICEAVLNNNNGSNGSVSGLRFLQPATDSGQVSMASTSSSRLRKSNSPVSASGMEASRSPQSSGSSTNNLHQQARQSGSPQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNRETINSGGNSELNFMSNETRIYEHPTTVLKSQRSLRQSPGSRDDLNLEVAVGVGGDYIYRQPANQPRSSSVKAEFLTTATTKSCTKTLDTCDYWPRCAACQHKSVSGELKKGPSASGKPLTVLDNVQPHVTSVIVNEDNAVPGPQLRSLEKSNPSWTFLCSGIASICQPVQQTETDHSTAQEAAEEDIVIRKVKPNKSRRTGRSRSLPSVMLRRLYLAGMPKPGSNEMGTTSDCAASLSQQIKAVSSPTLSEPCLEEQPQKGTESTDVANTGSSAGSGGLGVLQKFKRTLNNFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRATMAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLSQPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTSTGSLGRRHFGNWFRKPKSANCTPSQSPTHKPSFDADATLTEARVAAMELAEAAAALVPTDSSSA
InterPro domains: - IPR000219: Dbl homology domain (domain) [3027-3236]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [2873-2948]
- IPR001452: SH3 domain (domain) [2875-2946]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [3275-3363]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [3009-3255]
- IPR053086: RhoGEF domain-containing protein (family) [1459-3510]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [3260-3401]
Interaction partners: - Ras-related protein Rac1
- Cdc42 homolog
- Ras-like GTP-binding protein RhoL
- Ras-like GTP-binding protein Rho1
- Guanine nucleotide-binding protein subunit beta-1
- G protein beta subunit 5
- Amphiphysin
- AT17867p
- Gamma-aminobutyric acid receptor alpha-like
- IP12579p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0042440 (pigment metabolic process), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0006952 (defense response), GO:1901615 (organic hydroxy compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0035010 (encapsulation of foreign target), GO:0006582 (melanin metabolic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0035006 (melanization defense response), GO:0035011 (melanotic encapsulation of foreign target), GO:0018958 (phenol-containing compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0045179 (apical cortex), GO:0099738 (cell cortex region)