Protein: Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a) (P61625)
Organism: Bos taurus (Bovine)
Function: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20701}; Single-pass type I membrane protein {ECO:0000255}. Note=Upon antigen recognition by the TCR, is recruited to lipid rafts. {ECO:0000250|UniProtKB:P20701}.
Sequence: MNSCIIVLRLLLSGPFVFAPAWSYNLDVRHVQNFSFPLAGRHFGYRVLQVGNGVVVGAPSEGNSMGNLYQCQPETGDCLPVTLSSNYTSKYLGMTLATDPTSDNLLACDPGLSRTCDQNIYLSGLCYLIHENLRGPVLQGHPGYQECIKGNVDLVFLFDGSMSLQQDEFEKIVDFMKDVMKKLSNSSYQFAAVQFSTYFRTEFTFLDYIRQKDPDALLAGVKHMRLLTNTFGAINYVAKEVFRPDLGARPDATKVLIIITDGEATDEHNIDAAKDIIRYIIGIGKNFKTKESQEALHQFASKPVEEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSEGHGVVGAVGAKDWAGGFLDLKADLKSSTFVGNEPLTVESRAGYLGYTVTWLPSRGTMSLLATGAPRYQHVGRVLLFQQPKRGGPWSQIQEIDGIQIGSYFGGELCGVDVDRDGETELLLIAAPLYYGEQRGGRVFIYQKIQLEFQMVSELQGETGYPLGRFGAAIAALTDINGDELTDVAVGAPLEEQGAVYIFNGQQGGLSPRPSQRIEGTQMFSGIQWFGRSIHGVKDLGGDGLADVAVGAEGQVIVLSSRPVVDIITSVSFSPAEIPVHEVECSYSTSNQKKEGVNLTVCFQVKSLISTFQGHLVANLTYTLQLDGHRTRSRGLFPGGKHKLIGNTAVTPVKSCFVFWFHFPICIQDLISPINVSLSYSLWEEEGTPRDPRALDRDIPPILKPSPHLETKEIPFEKNCGEDKNCEADLKLAFSDMRSKILRLTPSASLSVRLTLRNTAEDAYWVQVTLSFPQGLSFRKVEILKPHSHVPVGCEELPEEAVVHSRALSCNVSSPIFGEDSMVDIQVMFNTLQKGSWGDFIELQANVSCNNEDSSLLEDNSATTSIPVMYPINVLTKDQENSTLYISFTPKSPKIHHVKHIYQVRIQPSNYDNMPPLEALVRVPRVHSEGLITHKWSIQMEPPVNCSPRNLESPSDEAESCSFGTEFRCPIDFRQEILVQVNGMVELRGTIKASSMLSLCSSLAISFNSSKHFHLYGRNASMAQVVMKVDLVYEKEMLYLYVLSGIGGLLLLFLIFIALYKVGFFKRNLKEKMEANVDASSEIPGEDAGQPELEKECKDPGCLEPLQKTDEDGSGGD
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [768-916]
- IPR002035: von Willebrand factor, type A (domain) [151-326]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1108-1123]
- IPR000413: Integrin alpha chain (family) [398-1115]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [609-766]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [24-611]
- IPR013517: FG-GAP repeat (repeat) [457-551]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [611-909]
- IPR013519: Integrin alpha beta-propellor (repeat) [29-624]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [108-329]
Interaction partners: - Integrin beta-2
- Intercellular adhesion molecule 1
- Intercellular adhesion molecule 3
- Integrin beta-1
- Intercellular adhesion molecule 5
- Junctional adhesion molecule A
- Proto-oncogene vav
- CD226 molecule
- Integrin subunit alpha M
- Intercellular adhesion molecule N-terminal domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)