Protein: Hydroxysteroid 17-beta dehydrogenase 4 (E7ET17)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Sequence: MKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1-153]
- IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [14-42]
- IPR051687: Peroxisomal Beta-Oxidation Enzymes (family) [1-474]
- IPR036527: SCP2 sterol-binding domain superfamily (homologous_superfamily) [480-599]
- IPR029069: HotDog domain superfamily (homologous_superfamily) [190-464]
- IPR003033: SCP2 sterol-binding domain (domain) [491-594]
- IPR002539: MaoC-like dehydratase domain (domain) [347-463]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [1-91]
- IPR054357: Peroxisomal multifunctional enzyme type 2-like, N-terminal domain (domain) [200-328]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016229 (steroid dehydrogenase activity), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0016835 (carbon-oxygen lyase activity), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0042803 (protein homodimerization activity), GO:0016836 (hydro-lyase activity), GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004303 (estradiol 17-beta-dehydrogenase activity), GO:0004300 (enoyl-CoA hydratase activity), GO:0003857 (3-hydroxyacyl-CoA dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0006807 (nitrogen compound metabolic process), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0001503 (ossification), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0001649 (osteoblast differentiation), GO:0044248 (cellular catabolic process), GO:0008210 (estrogen metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0008209 (androgen metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006629 (lipid metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0006790 (sulfur compound metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0008202 (steroid metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0016042 (lipid catabolic process), GO:0006631 (fatty acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0030258 (lipid modification), GO:1901568 (fatty acid derivative metabolic process), GO:0009117 (nucleotide metabolic process), GO:0035337 (fatty-acyl-CoA metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0019395 (fatty acid oxidation), GO:0006163 (purine nucleotide metabolic process), GO:0034440 (lipid oxidation), GO:0009062 (fatty acid catabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process), GO:0006635 (fatty acid beta-oxidation), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)