wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Uncharacterized protein C11C11.05 (Q10196)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MKTTMLMLVLLVCSYIHYVCAQIRFVTPATTDSMDFTAISFSWEESNTGIPLEDITNTVFYICSGSMDAPQPCAVLYTSPSPSSISQAGPFAISQVFGPAGRLYFLWAQSTYAGGIVNDYTDFFTVNGLTGTFDNYEIYASLMALGVYPYVPTLTGFSTFLGVWPTGTMRDWYLSQTTGVLRTGPIQNRPDSTFTAATTDIQPLWETSSYSVFTTFAGPPIATSTVFASPTYMYTLYANYASTASKPTIIATPTAGLRRRDSWAQAAPKRGMRLGEHKRGLLYS
InterPro domains: - IPR018466: Yeast cell wall synthesis Kre9/Knh1-like, N-terminal (domain) [27-126]
- IPR045328: Yeast cell wall synthesis Kre9/Knh1 (family) [1-271]
- IPR008659: Yeast cell wall synthesis Kre9/Knh1, C-terminal (domain) [173-249]
Interaction partners: - Protein big1
- Protein rot1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0044042 (glucan metabolic process), GO:0006073 (cellular glucan metabolic process), GO:0009250 (glucan biosynthetic process), GO:0051273 (beta-glucan metabolic process), GO:0051274 (beta-glucan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: EF-hand domain-containing protein (Q4QIT3)
Organism: Leishmania major
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Sequence: MTVVLCRSYETPTYLIPYYLRDVRSRFLHYASVRKRKGGPMYMTVEDFVLALLASPEKVLPNPDIVQDLQRLFESMDANGDGYISFPEFRFLMSLLTSDPHEVEALFSIVSTDNSGTLSLEEFANVLRGATKDEGVVRSLLKPSTRRNGIVRALFGDETAPRRCSFRELEALIHSVRTEVWKAEFRQYDVEKHNRITAEEFAALIARQVLGSHLPYYLVGNIRRLHGSGDVVTLDMWLGLNEVMLYAEQLAANVEMFSGSGMSVTKRDFPRLMSMAGVPALPQATIDIIFAVFDKNGDGSMEMDELLFIMRKKVKYHYSAPPHERKSLPKRFLECSSDVLAGLGR
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [63-313]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [77-306]
- IPR002048: EF-hand domain (domain) [64-316]
- IPR039800: Calcium uptake protein 1/2/3 (family) [23-319]
Interaction partners: - Calcium uniporter protein C-terminal domain-containing protein
- Calcium uniporter protein C-terminal domain-containing protein
- Calcium uniporter protein C-terminal domain-containing protein
- Prohibitin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0019953 (sexual reproduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)
Protein: Tubulin alpha 4a (C9JDS9)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRH
InterPro domains: - IPR036525: Tubulin/FtsZ, GTPase domain superfamily (homologous_superfamily) [1-112]
- IPR008280: Tubulin/FtsZ, C-terminal (homologous_superfamily) [96-156]
- IPR018316: Tubulin/FtsZ, 2-layer sandwich domain (domain) [110-156]
- IPR000217: Tubulin (family) [1-156]
- IPR002452: Alpha tubulin (family) [8-136]
- IPR003008: Tubulin/FtsZ, GTPase domain (domain) [1-93]
- IPR037103: Tubulin/FtsZ-like, C-terminal domain (homologous_superfamily) [113-156]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0031023 (microtubule organizing center organization), GO:0007098 (centrosome cycle), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Palmitoyltransferase PFA5 (EC 2.3.1.225) (Protein fatty acyltransferase 5) (Q9C0W9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MSTNLEEKQRRFSKLQKTLGVVFPAAILLSTGYTVWVFIALICVDSNIKIRNGYRNLGGGIVLIIFFFITSGLAYFSYFRVLFSSPSFCGNTLYTYYGFDNPIFLCGPNGAPRMCGTCKCWLPDRSHHSRVSMRCIRKFDHYCSFVGKDVCFSNQKFFYQFLFYGFSAACMVLISTAIMISRTYHYRSLPGTWIFVLVFSAFGVLFLGVMLVRHTGYLLLNINSHEAKNWKTRIYSFSVFFPEHMDSRVLVQSDPGDLPWDRGYSENWRAVMGDHWYNWILPLRRSPGDGEHFLYSPSFVSKMQSKALSMNS
InterPro domains: - IPR001594: Palmitoyltransferase, DHHC domain (domain) [111-230]
- IPR039859: Palmitoyltransferase PFA4/ZDHHC16/ZDHHC20/ERF2-like (family) [34-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016409 (palmitoyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0051668 (localization within membrane), GO:0070727 (cellular macromolecule localization), GO:0045184 (establishment of protein localization), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0008104 (protein localization), GO:1990778 (protein localization to cell periphery), GO:0061951 (establishment of protein localization to plasma membrane), GO:0072659 (protein localization to plasma membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cytochrome P450 (EC 1.14.14.1) (Q9WV19)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU368053}. Microsome membrane {ECO:0000256|RuleBase:RU368053}.
Sequence: MMLGGAFSIFMALCLSCLLILIAWKRTSKGGKLPPGPTPIPFLGNFLQVRTDATFQSFQKLQKKYGSVFTVYFGPRPVVVLCGHEAVKEALVDQADDFSGRGEMPTLEKNFQGYGLALSNGERWKILRRFSLTVLRNFGMGKRSIEERIQEEAGYLLEELHKVKGAPIDPTLYLSRTVSNVICSVVFGKRFDYQDQRFQSLMRMINESFVEMSKPWAQLYDMYWKVMQYFPGRHNYLYNLIEDLKDFIASRVKINEASFDPSNPRDFIDCFLIKMHQDKSDPHTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLLKYPEVEAKIHEEINQVIGTHRTPRVDDRAKMPYTDAVIHEIQRLTDIVPLGVPHNVTRDTHFRGYLLPKGTDVYPLFGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNDAFVVFSSGKRICVGEALARMELFLYFTSILQRFSLRSLVPPADIDIAHKISGFGNIPPVYELCFMAR
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [24-494]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [432-441]
- IPR001128: Cytochrome P450 (family) [34-491]
- IPR002401: Cytochrome P450, E-class, group I (family) [62-462]
- IPR050182: Cytochrome P450 family 2 (family) [10-474]
- IPR008067: Cytochrome P450, E-class, group I, CYP2A-like (family) [225-405]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0008391 (arachidonic acid monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0014070 (response to organic cyclic compound), GO:0035634 (response to stilbenoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Nucleophosmin (Q566X7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Sequence: RLTGPVRAKMEDNIKDLSRPQMYLFGCSLKGDKKEHKVDLDDDEAEHQLSLKSVCLGAEAEDKFHTVETEGLTYDGKTTKITLAVLKPSVLPSLSLGGFEVTPPVSFRLQSGGGPVYISGQHFVSVKESDDEDEEEEENNTSPVKRPSNMTLAKVPQKKLKMDSDEDEDSDDDDDDDDDDDDDEEDDDKQEKPAVKSPVKSTQKTPEKKKSADKQNGSPDKKAGTSGKPQTQTPQKVKDKSAAGPSGKTPSIPSLSEVKSKLTSAAKEGKPFPKTEQKFENFARSSFKISDKQVIKDLWNFVQSLKK
InterPro domains: - IPR032569: Nucleophosmin, C-terminal (domain) [257-304]
- IPR004301: Nucleoplasmin family (family) [17-302]
- IPR024057: Nucleoplasmin core domain (domain) [24-124]
- IPR036824: Nucleoplasmin core domain superfamily (homologous_superfamily) [19-124]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0050794 (regulation of cellular process), GO:0010941 (regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0043067 (regulation of programmed cell death), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Transthyretin (Prealbumin) (TBPA) (P27731)
Organism: Gallus gallus (Chicken)
Function: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Subcellular location: Secreted {ECO:0000269|PubMed:1833190, ECO:0000269|PubMed:8612621}.
Sequence: MAFHSTLLVFLAGLVFLSEAAPLVSHGSVDSKCPLMVKVLDAVRGSPAANVAVKVFKKAADGTWQDFATGKTTEFGEIHELTTEEQFVEGVYRVEFDTSSYWKGLGLSPFHEYADVVFTANDSGHRHYTIAALLSPFSYSTTAVVSDPQE
InterPro domains: - IPR000895: Transthyretin/hydroxyisourate hydrolase (family) [34-122]
- IPR023418: Transthyretin, thyroxine binding site (binding_site) [38-53]
- IPR023419: Transthyretin, conserved site (conserved_site) [128-140]
- IPR023416: Transthyretin/hydroxyisourate hydrolase domain (domain) [25-150]
- IPR036817: Transthyretin/hydroxyisourate hydrolase domain superfamily (homologous_superfamily) [21-150]
Interaction partners: - Retinol-binding protein 4
- Albumin
- Uncharacterized protein.
- Uncharacterized protein.
- Transthyretin
- Apolipoprotein A-I
- Uncharacterized protein.
- Alpha 2-HS glycoprotein.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0042562 (hormone binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043627 (response to estrogen)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Type IV pilin secretion protein (Q4QNP5)
Organism: Haemophilus influenzae (strain 86-028NP)
Function: Not known
Sequence: MTSYALLHTQRVTAQNGEIFTISPDLWERNQQQQSLLLRYFALPLKEENNRLWLGVDSLSNLSACETIAFITGKPVEPILLESSQLKELLQQLTPHQMQVEEQVKFYQHQETHFEQEDDEPVIRLLNQIFESALQKNASDIHLETLADQFQVRFRIDGVLQPQPLISKIFANRIISRLKLLAKLDISENRLPQDGRFQFKTTFSDILDFRLSTLPTHWGEKIVLRAQQNKPVELSFAELGMTENQQQAFQRSLSQPQGLILVTGPTGSGKSISLYTALQWLNTPDKHIMTAEDPIEIELDGIIQSQINPQIGLDFSRLLRAFLRQDPDIIMLGEIRDEESARIALRAAQTGHLVLSTLHTNDAISAISRLQQLGIQQHEIENSLLLVIAQRLVRKICPKCGGNLINSCDCHQGYRGRIGVYQFLHWQQNGYQTDFENLRESGLEKVSQGITDEKEIERVLGKNS
InterPro domains: - IPR007831: Type II secretion system protein GspE, N-terminal (domain) [22-98]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [109-463]
- IPR001482: Type II/IV secretion system domain (domain) [115-458]
- IPR037257: Type II secretion system protein GspE, N-terminal superfamily (homologous_superfamily) [22-92]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0043107 (type IV pilus-dependent motility), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0030031 (cell projection assembly), GO:0043711 (pilus organization), GO:0009297 (pilus assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0140737 (encapsulin nanocompartment)
Protein: TPR repeat protein oca3 (Overexpression-mediated cell cycle arrest protein 3) (O60110)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in cell cycle regulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. Note=Also localizes to the barrier septum.
Sequence: MSNSILKVPDQNPQEIVALFSQQEAYAKLGKYKDEIWDVYQKVFIAALTTGETVLAKKCWNRLNDRFHKSPRVEGLYGMFLEATASEKDAMSYYNSKLSEDPTHTVIYKRKLALLRSMGQTKECIQGLINYLDTFYNDLEAWAELADIYVSVEAFESAIFCYEEMVLLQPFEPRLFARLGDLYFVLAQSNATNYWFSLKHYCRSVEICEEYFHGWFGISKCCQQLLELSRTELKRLLSKVNEKISDTFPDTESVRQLYQLSLKKSDLFAQKQPKLKALLEQC
InterPro domains: - IPR039856: ER membrane protein complex subunit 2-like (family) [27-239]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [2-280]
- IPR055217: EMC2, TPR-like domain (domain) [76-174]
- IPR019734: Tetratricopeptide repeat (repeat) [139-172]
Interaction partners: - ER membrane protein complex subunit 3
- ER membrane protein complex subunit 6
- ER membrane protein complex subunit 4
- ER membrane protein complex subunit 1
- UPF0620 protein C83.10
- ER membrane protein complex subunit 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: DNA/RNA-binding domain-containing protein (SMG-7) (G5EF47)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MSDEWEQLTVELRKIPRGTEAAPQYLRHLMKMFVADFETAVSKRFDVKFWNKLKSMMDEITKAMENDRLVNHNVQNLAIGFLTDLSLLVHYHYEIPNYGNDISKQLTWTPDVFLNRKPIKSKKNSRVFMAYVLLRMGDLMRYKENYPKAQEYYEQSCRINPADGAVWNQLGLISSLGAKNLESVYFHTRALHATMEFPTASGGLTNIFKNFANRDISRPMPIKDLYLSCLGRIHFLLEIEDSSVHLQKIGEEAATSKEMIVPLMSVYKHLEDGTELEQRAVEYVKTIWCTAYRSLLKTLDDYKEESKKLADVPHLLHILALLLCAPKLLRGIEDQTEDEVTSICEWLLCANCDEKIKDSDAFGYFHCLQRIQYPLTRTQLAQKLVEIEDEDESKDSDQSTIPEEDQKSLSTDTSRIQNEDSEPESESESSDEEVLQRGRRRGRNPNLDESVETDEDEF
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1-437]
- IPR045153: Est1/Ebs1-like (family) [24-277]
- IPR019734: Tetratricopeptide repeat (repeat) [130-163]
- IPR018834: DNA/RNA-binding domain, Est1-type (domain) [149-339]
Interaction partners: - Nonsense-mediated mRNA decay protein
- PIN domain-containing protein
- Nonsense-mediated mRNA decay factor SMG9
- Nonsense-mediated mRNA decay factor SMG8
- UPF3 domain-containing protein
- Telomerase reverse transcriptase
- Serine/threonine-protein kinase smg-1
- 5'-3' exoribonuclease 1
- Regulator of nonsense transcripts 1
- MIF4G domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0030422 (siRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)