Protein: Dynamin-1 (EC 3.6.5.5) (Dynamin) (Q08DF4)
Organism: Bos taurus (Bovine)
Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q05193}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q05193}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P21575, ECO:0000250|UniProtKB:P39053}. Presynapse {ECO:0000250|UniProtKB:P21575}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000269|PubMed:11959911}. Note=Associated to the membrane in a helical polymer shape in a GTP bound state. Transiently recruited to endocytic clathrin-coated pits (CCPs) at a late stage of clathrin-coated vesicle (CCV) formation. {ECO:0000250|UniProtKB:Q05193}.
Sequence: MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTATIRKCSEKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKASGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPTGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSQPIGSGKSIPS
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [519-627]
- IPR030381: Dynamin-type guanine nucleotide-binding (G) domain (domain) [28-294]
- IPR000375: Dynamin stalk domain (domain) [215-501]
- IPR020850: GTPase effector domain (domain) [659-750]
- IPR022812: Dynamin (family) [7-744]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3-304]
- IPR045063: Dynamin, N-terminal (domain) [34-207]
- IPR001401: Dynamin, GTPase domain (domain) [6-294]
- IPR019762: Dynamin, GTPase region, conserved site (conserved_site) [57-66]
- IPR003130: Dynamin GTPase effector (domain) [654-745]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [521-653]
Interaction partners: - Src substrate cortactin
- Mitochondrial fission 1 protein
- Hematopoietic lineage cell-specific protein
- Dynamin-3
- Amphiphysin
- Dynamin-2
- Intersectin 2
- SH3 domain containing GRB2 like 2, endophilin A1
- Clathrin heavy chain 1
- Intersectin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0016050 (vesicle organization), GO:0006897 (endocytosis), GO:0007032 (endosome organization), GO:0006898 (receptor-mediated endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0005905 (clathrin-coated pit), GO:0098590 (plasma membrane region), GO:0098857 (membrane microdomain), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0043231 (intracellular membrane-bounded organelle), GO:0044853 (plasma membrane raft), GO:0005901 (caveola)