Protein: Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein multitype 1) (O35615)
Organism: Mus musculus (Mouse)
Function: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Subcellular location: Nucleus {ECO:0000269|PubMed:9230307}.
Sequence: MSRRKQSNPRQIKRSLRDMEAGEEAKAMDSSPKEQEAPDPEAPAIEEPPSPPREDVSPPAVPAPPESPEDPEDMEGQELEMRPQDEEKEEKEEEAAMASPWSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPAVTLMVDESCWLRMLPQVLTEEAANSEIYRKDDALWCRVTKVVPSGGLLYVRLVTEPHGAPRHPVQEPVEPGGLAPVHTDIQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQRAGSPVSATEEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHNCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAAKLPPDSLAGFQQHSLMHSPLVPADKAPTPSSGLDSKAEVTNGETRVPPQNGGSSESPAAPRTIKVEAAEEPEATRASGPGEPGPQAPSRTPSPHSPNPVRVKTELSSPTPGSSPGPGELTMAGTLFLPQYVFSPDAGTTTVPTAPQASEILAKMSELVHNRLQQGAGSSGAAGTPTGLFSGTKGATCFECEITFNNINNFYVHKRLYCSGRRAPEDPPTVRRPKAATGPARAPAGAAAEPDPSRSSPGPGPREEEASGTTTPEAEAAGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPPAPTTAPGPAAPALTAPPVRTRRRRKLYELPAAGAPPPAAGPAPVPVVPSPTAELPSSPRPGSASAGPAPALSPSPVPDGPIDLSKRPRRQSPDAPTALPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPLRTTALCPYCPPNGRVRGDLVEHLRQAHGLQVAKPAASPGAEPRTPAERAPRDSPDGRAPRSPSPAPENTPSDPADQGARTPSKGPPAPAPAPGGGGGHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK
InterPro domains: - IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [250-989]
- IPR013087: Zinc finger C2H2-type (domain) [255-989]
- IPR039746: FOG family (family) [1-865]
- IPR049361: Zinc finger protein ZFPM1/2, PR domain (domain) [104-198]
- IPR034731: Zinc finger CCHC FOG-type (domain) [249-990]
Interaction partners: - Erythroid transcription factor
- Endothelial transcription factor GATA-2
- Rhombotin-2
- LIM domain-binding protein 1
- Histone deacetylase 1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Krueppel-like factor 1
- Histone-binding protein RBBP7
- Transcription factor GATA-4
- Trans-acting T-cell-specific transcription factor GATA-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003714 (transcription corepressor activity), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0009653 (anatomical structure morphogenesis), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0045058 (T cell selection), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0048523 (negative regulation of cellular process), GO:0030220 (platelet formation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0002366 (leukocyte activation involved in immune response), GO:0030154 (cell differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:1903706 (regulation of hemopoiesis), GO:0001817 (regulation of cytokine production), GO:0031324 (negative regulation of cellular metabolic process), GO:0046649 (lymphocyte activation), GO:0000902 (cell morphogenesis), GO:0045165 (cell fate commitment), GO:2000026 (regulation of multicellular organismal development), GO:0043368 (positive T cell selection), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0002263 (cell activation involved in immune response), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0001818 (negative regulation of cytokine production), GO:0009890 (negative regulation of biosynthetic process), GO:0001819 (positive regulation of cytokine production), GO:0080090 (regulation of primary metabolic process), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0002360 (T cell lineage commitment), GO:0060284 (regulation of cell development), GO:0032649 (regulation of type II interferon production), GO:0010628 (positive regulation of gene expression), GO:0032673 (regulation of interleukin-4 production), GO:0032729 (positive regulation of type II interferon production), GO:0030099 (myeloid cell differentiation), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0043369 (CD4-positive or CD8-positive, alpha-beta T cell lineage commitment), GO:0045637 (regulation of myeloid cell differentiation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042110 (T cell activation), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:0002285 (lymphocyte activation involved in immune response), GO:0002286 (T cell activation involved in immune response), GO:0030217 (T cell differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045646 (regulation of erythrocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0002363 (alpha-beta T cell lineage commitment), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0046631 (alpha-beta T cell activation), GO:0036344 (platelet morphogenesis), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0035710 (CD4-positive, alpha-beta T cell activation), GO:0046632 (alpha-beta T cell differentiation), GO:0002292 (T cell differentiation involved in immune response), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0002287 (alpha-beta T cell activation involved in immune response), GO:0002293 (alpha-beta T cell differentiation involved in immune response), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0043367 (CD4-positive, alpha-beta T cell differentiation), GO:0002294 (CD4-positive, alpha-beta T cell differentiation involved in immune response), GO:0042093 (T-helper cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)