Protein: Cytoplasmic dynein 1 intermediate chain (DH IC) (Dynein intermediate chain, cytosolic) (Protein short wing) (Q24246)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9774695}.; SUBCELLULAR LOCATION: [Isoform 2c]: Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around lysosomes.; SUBCELLULAR LOCATION: [Isoform 2a]: Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around the nucleus.; SUBCELLULAR LOCATION: [Isoform 2b]: Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Aggregates in cytoplasm around the nucleus.
Sequence: MDRKAELERKKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAPVSEVLSSLSSVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSDEV
InterPro domains: - IPR001680: WD40 repeat (repeat) [298-632]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [225-660]
- IPR025956: Cytoplasmic dynein 1 intermediate chain 1/2 (family) [105-135]
- IPR050687: Dynein Intermediate Chain (family) [4-660]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [313-631]
Interaction partners: - Dynein light chain 1, cytoplasmic
- Dynein light chain Tctex-type
- Dynein light chain roadblock
- Sperm-specific dynein intermediate chain 2, isoform A
- FI21737p1
- GH16657p
- Sperm-specific dynein intermediate chain 1, isoform A
- Dynein light chain 2, cytoplasmic
- Dynein light intermediate chain
- Dynein heavy chain, cytoplasmic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0051640 (organelle localization), GO:0007018 (microtubule-based movement), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0140013 (meiotic nuclear division), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0007143 (female meiotic nuclear division), GO:0000226 (microtubule cytoskeleton organization), GO:0051647 (nucleus localization), GO:0010970 (transport along microtubule), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0006996 (organelle organization), GO:0007127 (meiosis I), GO:0099111 (microtubule-based transport), GO:0072384 (organelle transport along microtubule), GO:0007010 (cytoskeleton organization), GO:0048285 (organelle fission), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0005858 (axonemal dynein complex), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0030286 (dynein complex), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm), GO:0015630 (microtubule cytoskeleton)