Protein: Negative elongation factor E (A0A8J8XR86)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MVTVENDVLGSALEPGANMLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGTASQGGVKRSLSEQPVVDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQRKSLYESFVSSSDRLRELGQDGEEAEAPGAGEGPPRGFDWSYEEHSGARSSASPPRSRSRDRSHDRSRDRDRDKERDRDRDRDRERDKDKDRDRDRDRDKERDRDRDRERDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL
InterPro domains: - IPR034637: Negative elongation factor E, RNA recognition motif (domain) [274-348]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [225-346]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [273-359]
- IPR033102: Negative elongation factor E (family) [225-387]
- IPR000504: RNA recognition motif domain (domain) [278-348]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0031060 (regulation of histone methylation), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031062 (positive regulation of histone methylation), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0031399 (regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051571 (positive regulation of histone H3-K4 methylation), GO:0006355 (regulation of DNA-templated transcription), GO:0051569 (regulation of histone H3-K4 methylation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0031401 (positive regulation of protein modification process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0031058 (positive regulation of histone modification), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045893 (positive regulation of DNA-templated transcription), GO:0031056 (regulation of histone modification), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)