Protein: Calcium-transporting ATPase 1 (EC 7.2.2.10) (Ca(2+)-ATPase isoform 1) (Plastid envelope ATPase 1) (Q37145)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MESYLNENFGDVKPKNSSDEALQRWRKLCWIVKNPKRRFRFTANLSKRSEAEAIRRSNQEKFRVAVLVSQAALQFINSLKLSSEYTLPEEVRKAGFEICPDELGSIVEGHDLKKLKIHGGTEGLTEKLSTSIASGISTSEDLLSVRKEIYGINQFTESPSRGFWLFVWEALQDTTLMILAACAFVSLIVGILMEGWPIGAHDGLGIVASILLVVFVTATSDYRQSLQFKDLDAEKKKIVVQVTRDKLRQKISIYDLLPGDVVHLGIGDQIPADGLFISGFSVLINESSLTGESEPVSVSVEHPFLLSGTKVQDGSCKMLVTTVGMRTQWGKLMATLSEGGDDETPLQVKLNGVATIIGKIGLFFAVITFAVLVQGLANQKRLDNSHWIWTADELMAMLEYFAVAVTIVVVAVPEGLPLAVTLSLAFAMKKMMNDKALVRNLAACETMGSATTICSDKTGTLTTNHMTVVKACICEQAKEVNGPDAAMKFASGIPESAVKLLLQSIFTNTGGEIVVGKGNKTEILGTPTETALLEFGLSLGGDFQEVRQASNVVKVEPFNSTKKRMGVVIELPERHFRAHCKGASEIVLDSCDKYINKDGEVVPLDEKSTSHLKNIIEEFASEALRTLCLAYFEIGDEFSLEAPIPSGGYTCIGIVGIKDPVRPGVKESVAICKSAGITVRMVTGDNLTTAKAIARECGILTDDGIAIEGPEFREKSDEELLKLIPKLQVMARSSPMDKHTLVRLLRTMFQEVVAVTGDGTNDAPALHEADIGLAMGISGTEVAKESADVIILDDNFSTIVTVAKWGRSVYINIQKFVQFQLTVNVVALIVNFLSACLTGNAPLTAVQLLWVNMIMDTLGALALATEPPQDDLMKRSPVGRKGNFISNVMWRNILGQSLYQLVIIWCLQTKGKTMFGLDGPDSDLTLNTLIFNIFVFCQVFNEISSREMEKIDVFKGILKNYVFVAVLTCTVVFQVIIIELLGTFADTTPLNLGQWLVSIILGFLGMPVAAALKMIPVGSH
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [239-334]
- IPR001757: P-type ATPase (family) [387-838]
- IPR024750: Calcium-transporting P-type ATPase, N-terminal autoinhibitory domain (domain) [5-50]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [460-665]
- IPR036412: HAD-like superfamily (homologous_superfamily) [452-861]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [436-808]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [456-462]
- IPR006408: P-type ATPase, subfamily IIB (family) [114-1017]
- IPR023214: HAD superfamily (homologous_superfamily) [451-801]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [841-1015]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [116-191]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [119-1016]
Interaction partners: - Extensin-like protein
- Putative disease resistance protein At3g15700
- Alpha carbonic anhydrase 5
- Chloroplastic calcium uniporter protein
- GroES-like zinc-binding alcohol dehydrogenase family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0140358 (P-type transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0005516 (calmodulin binding), GO:0022804 (active transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0071702 (organic substance transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0070588 (calcium ion transmembrane transport), GO:0006816 (calcium ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)