Protein: Target of rapamycin complex 2 subunit AVO2 (TORC2 subunit AVO2) (Adheres voraciously to TOR2 protein 2) (Q04749)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12631735}; Peripheral membrane protein {ECO:0000269|PubMed:12631735}; Cytoplasmic side {ECO:0000269|PubMed:12631735}. Vacuole membrane {ECO:0000269|PubMed:12631735}; Peripheral membrane protein {ECO:0000269|PubMed:12631735}; Cytoplasmic side {ECO:0000269|PubMed:12631735}.
Sequence: MLKEPSVRLREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQTFEVGNIYSKVLKEVKKKGPPLGAGKKPSSFRTPILNAKATFEDGPSPVLSMNSPYSLYSNNSPLPVLPRRISTHTTSGNGGNRRSSITNPVFNPRKPTLSTDSFSSSSNSSSRLRVNSINVKTPVGVSPKKELVSESVRHSATPTSPHNNIALINRYLLPNKSNDNVRGDSQTATINDDGGGGNGGDATIGMGLRKDPDDENENKYKIKVNNGEPRRRVSLLNIPISKLRNSNNTRAED
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [6-204]
- IPR002110: Ankyrin repeat (repeat) [39-185]
Interaction partners: - Serine/threonine-protein kinase TOR2
- Target of rapamycin complex 2 subunit AVO1
- Target of rapamycin complex subunit LST8
- Target of rapamycin complex 2 subunit TSC11
- Target of rapamycin complex 2 subunit BIT61
- Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1
- Probable target of rapamycin complex 2 subunit BIT2
- Target of rapamycin complex 1 subunit TCO89
- Target of rapamycin complex 1 subunit KOG1
- Serine/threonine-protein kinase TOR1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0090068 (positive regulation of cell cycle process), GO:0035556 (intracellular signal transduction), GO:0010564 (regulation of cell cycle process), GO:0045787 (positive regulation of cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0007264 (small GTPase mediated signal transduction), GO:0045931 (positive regulation of mitotic cell cycle), GO:1901989 (positive regulation of cell cycle phase transition), GO:1901987 (regulation of cell cycle phase transition), GO:0007265 (Ras protein signal transduction), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0007096 (regulation of exit from mitosis), GO:0007266 (Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)