Protein: Exchange protein directly activated by cAMP, isoform D (GH01501p) (Q7K3Z6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL
InterPro domains: - IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [612-860]
- IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [618-859]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [51-189]
- IPR019804: Ras guanine-nucleotide exchange factor, conserved site (conserved_site) [771-800]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [509-613]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [224-348]
- IPR000159: Ras-associating domain (domain) [515-597]
- IPR008937: Ras-like guanine nucleotide exchange factor (family) [91-859]
- IPR000591: DEP domain (domain) [64-139]
- IPR000595: Cyclic nucleotide-binding domain (domain) [207-326]
- IPR000651: Ras-like guanine nucleotide exchange factor, N-terminal (domain) [340-474]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [308-858]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [162-311]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [45-146]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0046578 (regulation of Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)