Protein: Origin recognition complex subunit 2 (Q60862)
Organism: Mus musculus (Mouse)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity).
Subcellular location: Nucleus.
Sequence: MSTLQLKETKVPSVQFVGDDDVLSHILDREGGTKLKKEKAQLLVNPQKVIKKADCELEKSDLEVLEDQNYVKVLGRNIQESLGNGSAKDGRNKVYSFQQRKHPEEMTKLALELAKTSGKKDPLDSNDPEITKNIAQKSKGHSTSEKAPLVNNNKTEFLSTQPHNLRKRIIASRSHYDSESEYSASSSEDDEEATKDEEEDTNVARLSQKSQGQNRLLPAPVSKETLPKKKKRDKASDLVEEYFEAHSSSKVLTSDRTLQRLRRARVDQKTLHNLLRKFVPSFSAEIERLNQQHEKLFHKWMLQLHLGFNIVLYGLGSKRDLLEKFRTTMLQDSIHVVINGYFPGVSVKSILNSITEDVLSHVGTFQSVLDQRDWIINRFKEDSSLELFLLIHNLDSQMLRGDNSQQILGQLSSLHNVYLIASIDHLNAPLMWDHAKQSLYNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLIHVLRSLTPNARGIFRLLMKFQLDNQDSPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDSGILADFLEKEEEEA
InterPro domains: - IPR007220: Origin recognition complex, subunit 2 (family) [93-573]
- IPR056772: Origin recognition complex subunit 2, RecA-like domain (domain) [254-500]
- IPR056773: Origin recognition complex subunit 2, winged-helix domain (domain) [504-562]
Interaction partners: - Origin recognition complex subunit 1
- Origin recognition complex subunit 6
- DNA replication licensing factor MCM2
- Origin recognition complex subunit 4
- Origin recognition complex subunit 5
- Cell division control protein 6 homolog
- Origin recognition complex subunit 3
- DNA replication licensing factor MCM5
- DNA replication factor Cdt1
- DNA replication licensing factor MCM3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0007017 (microtubule-based process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:1901576 (organic substance biosynthetic process), GO:1903047 (mitotic cell cycle process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0007051 (spindle organization), GO:0007307 (eggshell chorion gene amplification), GO:0044249 (cellular biosynthetic process), GO:0000226 (microtubule cytoskeleton organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0016043 (cellular component organization), GO:0007306 (egg chorion assembly), GO:0044260 (cellular macromolecule metabolic process), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0098813 (nuclear chromosome segregation), GO:0007076 (mitotic chromosome condensation), GO:0019438 (aromatic compound biosynthetic process), GO:0140014 (mitotic nuclear division), GO:0007052 (mitotic spindle organization), GO:0045229 (external encapsulating structure organization), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0071897 (DNA biosynthetic process), GO:0006270 (DNA replication initiation), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0007010 (cytoskeleton organization), GO:0006260 (DNA replication), GO:0000819 (sister chromatid segregation), GO:0006261 (DNA-templated DNA replication), GO:0000280 (nuclear division), GO:0030261 (chromosome condensation), GO:0006277 (DNA amplification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)