Protein: SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk) (Q9UQQ2)
Organism: Homo sapiens (Human)
Function: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Sequence: MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAKKFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQHLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [195-309]
- IPR030523: SH2B adapter protein (family) [1-341]
- IPR035059: SH2B3, SH2 domain (domain) [355-451]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [343-465]
- IPR015012: Phenylalanine zipper (domain) [25-80]
- IPR000980: SH2 domain (domain) [362-462]
- IPR036290: Phenylalanine zipper superfamily (homologous_superfamily) [24-84]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [186-312]
Interaction partners: - Tyrosine-protein kinase JAK2
- Growth factor receptor-bound protein 2
- NT-3 growth factor receptor
- SH2B adapter protein 1
- High affinity nerve growth factor receptor
- BDNF/NT-3 growth factors receptor
- Polycomb group protein ASXL1
- Mast/stem cell growth factor receptor Kit
- Methylcytosine dioxygenase TET2
- T-cell activation Rho GTPase-activating protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0060390 (regulation of SMAD protein signal transduction), GO:0060391 (positive regulation of SMAD protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)