Protein: Tetratricopeptide repeat protein 30 homolog (TPR repeat protein 30 homolog) (Q9VK41)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for polyglutamylation of axonemal tubulin in sensory cilia. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Sequence: MLHQGIILREGHVTRTIYNLIKDKRYEDVIECITSFGEAANTRAGLSTLGHCYYHAQKYEEAATCYEQLCQLAPKEAKYRFYYAQSLYQAGIFADALRVLKQMGDQEDELREQCLQLQSAILYSSEDFAGAQSLLNQRAGGTADTLNDEGCLLFQADQHEAAVQRFQAALQVGGFNPLVAYNVALAHFQKKQRAQALDYTSEIVERGMRNHPELGIGAQMDIPDGGARSVGNPITMAISGITQALNLKAAIEFQDGNEEAARDALLDLPPRAESELDPVTLHNMALTDVEGPVAGLRKLAFLLELGAPSCPKETFANILLICCKNELYETAADILAEHTDLTYKYLSQYLYELLDSLITAQTSAELAEKKLGTLASSLAGKLRSLAAKVQEVRATNEQQALRDALKDYEQALELYLPVVMARAWISWRDDDFVGAEREFHASAEFCSENSIWRLNAGHVLFMQGDKYNEAAAFYEPIVRQHSDDIMSVSAAVLANLCVSYIMTFQNEEAEELMRKVEKAEEMKGNLGKQYHHLCIVNLVVGTLYCAKSNYEFGLSRIAHALESGSGNRLYADTWLHVKHCILGLLTGMAKQNIILPYATVQEVLNFLRFCESYGLFTPANIFSATEQVPEEPLTIGLEARKLRLLLIKLSEYDNF
InterPro domains: - IPR013105: Tetratricopeptide repeat 2 (repeat) [45-75]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [15-580]
- IPR019734: Tetratricopeptide repeat (repeat) [43-210]
- IPR039941: Tetratricopeptide repeat protein 30 (family) [8-651]
Interaction partners: - Intraflagellar transport protein 172 homolog
- No mechanoreceptor potential B, isoform D
- GH11140p
- Outer segment 5
- Clusterin associated protein 1
- Intraflagellar transport 52
- Intraflagellar transport protein 57 homolog
- TRAF3-interacting protein 1
- Intraflagellar transport protein 46 homolog
- WD repeat-containing protein 35
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0007017 (microtubule-based process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0042073 (intraciliary transport), GO:0007018 (microtubule-based movement), GO:1901564 (organonitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0019538 (protein metabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0051668 (localization within membrane), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0010970 (transport along microtubule), GO:0043412 (macromolecule modification), GO:0030030 (cell projection organization), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0099111 (microtubule-based transport), GO:0072657 (protein localization to membrane), GO:0072659 (protein localization to plasma membrane), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:1990778 (protein localization to cell periphery), GO:0018193 (peptidyl-amino acid modification), GO:0018200 (peptidyl-glutamic acid modification), GO:0018095 (protein polyglutamylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0030990 (intraciliary transport particle), GO:0042995 (cell projection), GO:0030992 (intraciliary transport particle B), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0097730 (non-motile cilium)