Protein: Homoserine dehydrogenase (HDH) (EC 1.1.1.3) (Q5AIA2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MSKSVNVAIIGSGVVGSSYLSQLNNLKSNIAFNVIYLAKTSEEALYSKDYSPVDLSTYETAPTQPTLSLDDLVKFIKGAKKPTVLVDNTSSPAIANYYPTFIKEGISIATPNKKAFSSDLKEWKEILQTAELPGAGLVYHECTVGAALPIISPLKDLIATGDKVDKIEGIFSGTLSYIFNEFSKTEKSDVKFSDVVKKAKELGYTEPDPRDDLNGLDVARKVTILARISGLEVEGPTSFPVESLIPKELECVESVAEFMEKLPNYDADIQKVKDEAFAENKVLRFVGKVDLNTNKVSVEIGKYGFDHPFASLKGSDNVVSIKTGRYPNPLIVQGAGAGAEITAHGVLADTIKIAERIAN
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1-171]
- IPR001342: Homoserine dehydrogenase, catalytic (domain) [149-351]
- IPR022697: Homoserine dehydrogenase lacking ACT domain (family) [2-359]
- IPR019811: Homoserine dehydrogenase, conserved site (conserved_site) [199-221]
- IPR011147: Bifunctional aspartokinase/homoserine dehydrogenase, homoserine dehydrogenase domain (domain) [2-357]
- IPR005106: Aspartate/homoserine dehydrogenase, NAD-binding (domain) [11-137]
Interaction partners: - Homoserine kinase
- Threonine synthase
- Aspartate-semialdehyde dehydrogenase
- Aspartokinase
- Homoserine O-acetyltransferase
- Acetolactate synthase regulatory subunit
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Branched-chain-amino-acid aminotransferase
- Branched-chain-amino-acid aminotransferase
- S-adenosylmethionine-homocysteine S-methyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0000096 (sulfur amino acid metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0000097 (sulfur amino acid biosynthetic process), GO:0009069 (serine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0006555 (methionine metabolic process), GO:0009070 (serine family amino acid biosynthetic process), GO:0006566 (threonine metabolic process), GO:0009086 (methionine biosynthetic process), GO:0009067 (aspartate family amino acid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall), GO:0030445 (yeast-form cell wall)