Protein: DNA replication licensing factor MCM4 (EC 3.6.4.12) (Q6NZV2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MSSPSSQSRKRDPPTPASEDPLSPPSQRSRAHDTSTELQPMPTSPAQDASLFSSPMAPRSVLQSEIDASSPLMYGTPSSRVEGTPRSGIRGTPARQRADLGSVRKAPQVDMHSEPASGDAAVAGDQGAGQRLVIWGTDVNVGTCKEKFQRFLQQFTDPDSREEENAGLDLNEPLYMQKLDEISVVGEPVLNVNCTHIQTFDADLYRQLICYPQEVIPTFDMSVNELFFDRFPDSVLEHQIQVRPYSAIKTRNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFNTRVEVDRGRIAEPAVCRNCNTTHSMALVHNRSVFSDKQMIKLQESPEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVNITGIYRAAPMRLNPRQSQVKSVYKTHIDAIHFRKTDEKRLHGLDEDGEQKLFTKERVALLKELAAKPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFTQTGRGNFRAEVNILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTRSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQIEEEHLDMAVLKDYIAFARTTVHPRLSEEASQALIEAYVDMRKIGSGRGMVSAYPRQLESLIRLAEAHAKVRFSGKVETIDVEEAKRLHREALKQSATDPRTGFVDISILTTGMSATARKRKEEVAQALKKLIQSKGKTPAMKYQQLFDDLRGQSEAAITKDMFDEALRLLADEDYLTVTGKTVRLL
InterPro domains: - IPR031327: Mini-chromosome maintenance protein (family) [145-804]
- IPR008047: Mini-chromosome maintenance complex protein 4 (family) [275-761]
- IPR027925: MCM, N-terminal domain (domain) [145-246]
- IPR003593: AAA+ ATPase domain (domain) [484-636]
- IPR033762: MCM OB domain (domain) [252-379]
- IPR041562: MCM, AAA-lid domain (domain) [668-750]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [421-764]
- IPR018525: Mini-chromosome maintenance, conserved site (conserved_site) [551-559]
- IPR001208: MCM domain (domain) [430-652]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [147-400]
Interaction partners: - DNA helicase
- WD repeat and HMG-box DNA-binding protein 1
- Cell division cycle 7 homolog
- DNA replication licensing factor MCM7
- Chromatin licensing and DNA replication factor 1
- Cell division control protein
- DNA helicase
- DNA replication licensing factor MCM2
- CDC45 cell division cycle 45 homolog
- DNA replication complex GINS protein SLD5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006275 (regulation of DNA replication), GO:0090329 (regulation of DNA-templated DNA replication), GO:0030174 (regulation of DNA-templated DNA replication initiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0031974 (membrane-enclosed lumen), GO:0140513 (nuclear protein-containing complex), GO:0042555 (MCM complex), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0031261 (DNA replication preinitiation complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0071162 (CMG complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)