Protein: ATP synthase subunit delta, mitochondrial (F-ATPase delta subunit) (Q12165)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular location: Mitochondrion. Mitochondrion inner membrane {ECO:0000269|PubMed:10576729}.
Sequence: MLRSIIGKSASRSLNFVAKRSYAEAAAASSGLKLQFALPHETLYSGSEVTQVNLPAKSGRIGVLANHVPTVEQLLPGVVEVMEGSNSKKFFISGGFATVQPDSQLCVTAIEAFPLESFSQENIKNLLAEAKKNVSSSDAREAAEAAIQVEVLENLQSVLK
InterPro domains: - IPR048938: F1F0-ATP synthase subunit delta, C-terminal domain, fungi (domain) [118-157]
- IPR001469: ATP synthase, F1 complex, delta/epsilon subunit (family) [20-159]
- IPR036771: F0F1 ATP synthase delta/epsilon subunit, N-terminal (homologous_superfamily) [23-119]
- IPR020546: ATP synthase, F1 complex, delta/epsilon subunit, N-terminal (domain) [32-103]
Interaction partners: - ATP synthase subunit J, mitochondrial
- ATP synthase subunit a
- ATP synthase subunit g, mitochondrial
- ATP synthase subunit 4
- ATP synthase subunit 9, mitochondrial
- ATP synthase subunit alpha
- ATP synthase subunit gamma, mitochondrial
- ATP synthase subunit beta, mitochondrial
- ATP synthase subunit 5, mitochondrial
- ATP synthase subunit H
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0016874 (ligase activity), GO:0022857 (transmembrane transporter activity), GO:0046933 (proton-transporting ATP synthase activity, rotational mechanism), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0015078 (proton transmembrane transporter activity), GO:0015252 (proton channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0016043 (cellular component organization), GO:0006091 (generation of precursor metabolites and energy), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:1901566 (organonitrogen compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0043933 (protein-containing complex organization), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0065003 (protein-containing complex assembly), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0045333 (cellular respiration), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009060 (aerobic respiration), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0070071 (proton-transporting two-sector ATPase complex assembly), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009145 (purine nucleoside triphosphate biosynthetic process), GO:0006119 (oxidative phosphorylation), GO:0009201 (ribonucleoside triphosphate biosynthetic process), GO:0046034 (ATP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0006754 (ATP biosynthetic process), GO:0042776 (proton motive force-driven mitochondrial ATP synthesis), GO:0009206 (purine ribonucleoside triphosphate biosynthetic process), GO:0015986 (proton motive force-driven ATP synthesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0016469 (proton-transporting two-sector ATPase complex), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0045261 (proton-transporting ATP synthase complex, catalytic core F(1)), GO:0005739 (mitochondrion), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0033178 (proton-transporting two-sector ATPase complex, catalytic domain), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0005753 (mitochondrial proton-transporting ATP synthase complex), GO:0019866 (organelle inner membrane), GO:0045259 (proton-transporting ATP synthase complex), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)