Protein: Methylcytosine dioxygenase TET (A0A8M1P9L5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development
Subcellular location: Chromosome
Sequence: MEIGSHERLEEGLLNQELSNGLSKHASNEENVCDNEDRDATKEQHQHNFHEGAGSISQTPGWVLEHTGKLSNPESQQGVWSGQNASTTVNDVDMEDAQTLVAFSVGSLPPYTNHQPSPTPTAQLYERFNQEMSNGGEEAKKKGVDGAFCPPEDLNTLQAALSKARHGHKPPNCDCDGPDCPDYLEWLEKQIKLVTNCQNKTSCNLSGTAQQPLEQHHYSQSQPQQCGGKPLCVQDTNPQPLVNKPSTPRPFGPPAPIPCSPSVLSIAKERNVSLQTAIAIEALTQLSATVPQTVVPPGESSLANHHQHLPTSYHQNMPQVVSSSPGPLLSSSATSAIPQSNHYPQQELTTWEQQRPQSKGEAPTANIFPSSSHYSSSYPSSKPPFTNMHASSPNPRPQQWNQGTASSCEKNSPRNAWMMANTDSKQHFAKPSHESSDPVSELKQLLGDTGGKHPFKFPFPHPSLQDVHKGSFTGMPHIKQEVETKEYLGSECSVMGQEGMLNGQQQFQGQQLSSTIRHSTQAALQQHLHHKRNLFSNSPTYGPLAHMACQDLRKWWPQTIPENLINIKQEHKEPKKKKGAQSSHLKQPAGGPFGPLGTPLPKPKPIVIKKHKQKASQPTFLPQIQITISKPPLISPGYAPSRAQLVPSLPGMEAGLPPTQVAESHPAPAQSQESIINCSSAPISENSHSSTNPVSVLAPSTQKVIACPGSAGSNDSIPTTSITPQTSTTQPSPSLAGLSNLDPKFEELIRQFEEEFGDTAASAAETPENGPVQPVVTESHPNSGQLRPESPSLKQPNNCPPVPTNESEPMNEGQKDIPERQKEKTPLPPEELCTVKQESEECALDVKPSGELLSEFLKQQNPFVAPFSPPNKRMKIESSNGVTVLSTTACFSADREGDDFNTPTKDIFPSSPSLKGFLESPLRYLDTPTKNLLDTPGKDVQPDFPICDCVDQVLEKDEGPYYNHLGSGRDIPSVRQLMEDRYGEKGEAVRIEKVVYTGREGKSSQGCPIAKWVLRRSSEKEKVLCVVKQRPGHHCANTVIVVVILAWEGVPRALGDKLYREVTETITKYGNPTSRRCGLNEDRTCACQGKDPETCGASFSFGCSWSMYFNGCKYARSKVPRKFRLQGEHPKEEDNLRDNFQALATHVAPLYKKLAPQAYSNQCLHEDVASDCRLGLKEGRPFSGITACMDFCAHAHKDQHNLHNGCTVVCTLTKEDNRTVGTIPEDEQLHVLPLYKLATTDEFGSEENQRLKMQTGAIQVLANFRREVRKLPEPAKSCRQRRLEAKKAASEKKNRKLQLAETPEKTVKMEIRHAESPHIQQGNKAIPKQEVKPTIKKEPVDHFQPFNGAIHGYQALGNGKTNPDPHNMNSSFSYPGNYARGRIPGNSHPPAQNPINGFHPNLQDIRYGYYNYPSSALFSPELLRYDKGAWPKNGEPSAQAFEQKPDVQCLQANLAQAYPTHHGQSQAQMADASIQGYPQPSDISQCRTPSMSLEQTHRSKPIVKQEPMDVPLYEARSDGQAQSCPTTPSTTPTPEGWHGHKPNGSLVPKGWDGNIRAASNNSPFTPDKQRLHQQHQHEHPQYPQQQQWNSYSCPNTPMASPAPSPSPSLKAGLSPAPSPHPSTPRQWGSPAPSPQPKAWGPYGPMGYGAGVIRQGNPAGAYPDNMLSQAGVNCGSAPLGLQEKAWKSGGGSAAGSTPSPAPEGRLFPDALQRSDGQACWDSGAETQSERDPEEDEVWSDSEHNFLDPNIGGVAVAPAHGCVLIECARRELHATTPLKKPDRTHPSRISLVFYQHKNLNQPCHGLALWESKMKILAERARQRQQEAALLGLSQEEIKAYGKKRKWAAGSASPSPGQTKDKREGVVTRMAPTQHSTTIVTVSPYPSTHLTGPYSRFV
InterPro domains: - IPR046942: Methylcytosine dioxygenase TET1-3, oxygenase domain (domain) [1104-1795]
- IPR040175: Methylcytosine dioxygenase TET1/2/3 (family) [2-1895]
- IPR024779: 2OGFeDO JBP1/TET, oxygenase domain (domain) [1104-1795]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016887 (ATP hydrolysis activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0034101 (erythrocyte homeostasis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048863 (stem cell differentiation), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0030218 (erythrocyte differentiation), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0030099 (myeloid cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)