Protein: Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) (Q07079)
Organism: Mus musculus (Mouse)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular location: Secreted {ECO:0000269|PubMed:26854565}. Cytoplasm {ECO:0000250|UniProtKB:P24593}. Nucleus {ECO:0000250|UniProtKB:P24593}.
Sequence: MVISVVLLLLAAYAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE
InterPro domains: - IPR017891: Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site (conserved_site) [51-66]
- IPR036857: Thyroglobulin type-1 superfamily (homologous_superfamily) [179-264]
- IPR000867: Insulin-like growth factor-binding protein, IGFBP (domain) [22-102]
- IPR012213: Insulin-like growth factor binding protein 5 (family) [34-267]
- IPR022321: Insulin-like growth factor-binding protein family 1-6, chordata (family) [63-243]
- IPR000716: Thyroglobulin type-1 (domain) [188-266]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [23-104]
Interaction partners: - Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin-like growth factor-binding protein complex acid labile subunit
- Insulin-like growth factor-binding protein 3
- Pappalysin-1
- Insulin-like growth factor-binding protein 6
- Platelet-derived growth factor subunit A
- Pappalysin 2
- Fibronectin
- Platelet-derived growth factor subunit B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0005520 (insulin-like growth factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0008283 (cell population proliferation), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0045926 (negative regulation of growth), GO:0001763 (morphogenesis of a branching structure), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003279 (cardiac septum development), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0046620 (regulation of organ growth), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0072028 (nephron morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0072006 (nephron development), GO:0048638 (regulation of developmental growth), GO:0008284 (positive regulation of cell population proliferation), GO:0035239 (tube morphogenesis), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0198738 (cell-cell signaling by wnt), GO:0001568 (blood vessel development), GO:0008285 (negative regulation of cell population proliferation), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0061138 (morphogenesis of a branching epithelium), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0048144 (fibroblast proliferation), GO:0061061 (muscle structure development), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0048640 (negative regulation of developmental growth), GO:0050673 (epithelial cell proliferation), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0060425 (lung morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0072009 (nephron epithelium development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0016055 (Wnt signaling pathway), GO:0072088 (nephron epithelium morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060993 (kidney morphogenesis), GO:0010468 (regulation of gene expression), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0061326 (renal tubule development), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0007507 (heart development), GO:0072001 (renal system development), GO:0043491 (protein kinase B signaling), GO:0072001 (renal system development), GO:0043491 (protein kinase B signaling), GO:0072001 (renal system development), GO:0043491 (protein kinase B signaling), GO:0007224 (smoothened signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071310 (cellular response to organic substance), GO:0016055 (Wnt signaling pathway), GO:0051248 (negative regulation of protein metabolic process), GO:0030111 (regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0035108 (limb morphogenesis), GO:0008589 (regulation of smoothened signaling pathway), GO:0060993 (kidney morphogenesis), GO:0030855 (epithelial cell differentiation), GO:0072175 (epithelial tube formation), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0033993 (response to lipid), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0035113 (embryonic appendage morphogenesis), GO:0014070 (response to organic cyclic compound), GO:0060429 (epithelium development), GO:0072210 (metanephric nephron development), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0045661 (regulation of myoblast differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0072080 (nephron tubule development), GO:0001823 (mesonephros development), GO:0014706 (striated muscle tissue development), GO:0001823 (mesonephros development), GO:0060231 (mesenchymal to epithelial transition), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0001656 (metanephros development), GO:0061333 (renal tubule morphogenesis), GO:0001658 (branching involved in ureteric bud morphogenesis), GO:0055007 (cardiac muscle cell differentiation), GO:0001657 (ureteric bud development), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0001657 (ureteric bud development), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0072171 (mesonephric tubule morphogenesis), GO:0031401 (positive regulation of protein modification process), GO:0043009 (chordate embryonic development), GO:0048738 (cardiac muscle tissue development), GO:0031399 (regulation of protein modification process), GO:0072073 (kidney epithelium development), GO:0006355 (regulation of DNA-templated transcription), GO:0071320 (cellular response to cAMP), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:1901224 (positive regulation of NIK/NF-kappaB signaling), GO:0051146 (striated muscle cell differentiation), GO:0072078 (nephron tubule morphogenesis), GO:0072078 (nephron tubule morphogenesis), GO:0001932 (regulation of protein phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0060675 (ureteric bud morphogenesis), GO:0072163 (mesonephric epithelium development), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)