Protein: Hephaestus, isoform Y (A0A0B4K6W9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MMSCPIPMPMPISSLHKSEFEPVNIGVKQMQLLHAPASTHPHPHPHQHPQHSAASAAAYQAMQVHQQQHQQQQQAAVFHHQVAAIAAQQQQQQQQAQVQHQQQMQQQFHYQAQAQAQAQAMLQTYMQLQVNSAVGVSTAPATPTKPVAAQIPGAISGPIAGPVPVSVPTQFFTAPSTPLTIIPAAAVASSAMFATAATPTSAATTPTNNVNNTVNLSAVSRTTTTTTKKQPQAVADAVLSAVGGNVGTAVGGGTISSLLGPEPLPIMPHHLPLASVRGCSSASSGCSSASSDCSMPSPTSLHLSSPKKVRIDEQYIYKLNYLRGSDELLSQAAVMAPASDNNNQDLATKKAKLEPGTVLAGGIAKASKVIHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRMVYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQNTSAVNAGGNTNAAGGPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKNNSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALPPGEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSVNGLGAPGVLPPFALGLGTPLTGGYNNALPNLAAFSLANSGALQTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSALIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPGSKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLALIKMHNHQLSESNHLRVSFSKSNI
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [361-885]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [360-898]
- IPR006536: HnRNP-L/PTB (family) [366-898]
- IPR021790: PTBP1-like, RNA recognition motif 2 (domain) [512-592]
- IPR000504: RNA recognition motif domain (domain) [368-896]
Interaction partners: - Heterogeneous nuclear ribonucleoprotein K, isoform C
- Heterogeneous nuclear ribonucleoprotein A1
- Smooth, isoform T
- LD40489p
- Uncharacterized protein, isoform C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005488 (binding), GO:0030371 (translation repressor activity), GO:0097159 (organic cyclic compound binding), GO:0090079 (translation regulator activity, nucleic acid binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0000900 (mRNA regulatory element binding translation repressor activity), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007163 (establishment or maintenance of cell polarity), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0009892 (negative regulation of metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0007017 (microtubule-based process), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007281 (germ cell development), GO:0007552 (metamorphosis), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0007309 (oocyte axis specification), GO:0009798 (axis specification), GO:0007349 (cellularization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0048515 (spermatid differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0007308 (oocyte construction), GO:0035107 (appendage morphogenesis), GO:0000226 (microtubule cytoskeleton organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0007283 (spermatogenesis), GO:0071695 (anatomical structure maturation), GO:0009887 (animal organ morphogenesis), GO:0008103 (oocyte microtubule cytoskeleton polarization), GO:0007291 (sperm individualization), GO:0048469 (cell maturation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0030952 (establishment or maintenance of cytoskeleton polarity), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0009994 (oocyte differentiation), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0016325 (oocyte microtubule cytoskeleton organization), GO:0030951 (establishment or maintenance of microtubule cytoskeleton polarity), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0035120 (post-embryonic appendage morphogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0048707 (instar larval or pupal morphogenesis), GO:0048477 (oogenesis), GO:0008586 (imaginal disc-derived wing vein morphogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0007286 (spermatid development), GO:0010468 (regulation of gene expression), GO:0008587 (imaginal disc-derived wing margin morphogenesis), GO:0034248 (regulation of amide metabolic process), GO:0048737 (imaginal disc-derived appendage development), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0048569 (post-embryonic animal organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0007444 (imaginal disc development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:0017148 (negative regulation of translation), GO:0007472 (wing disc morphogenesis), GO:0035220 (wing disc development), GO:0007010 (cytoskeleton organization), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0006417 (regulation of translation), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0010608 (post-transcriptional regulation of gene expression), GO:0046011 (regulation of oskar mRNA translation), GO:0007319 (negative regulation of oskar mRNA translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)