Protein: E3 ubiquitin ligase complex SCF subunit sconC (Sulfur controller C) (Sulfur metabolite repression control protein C) (Q5BAX8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
Sequence: MAEKMLVMTSNDGKNIEVPRDVAERSLLIKNMLEDLGDPTEPIPIPNVSENVLSKVLEWCAHHRNDPPSSADDDDSRRKTTDIEEWDQKFMQVDQEMLFEIILAANYLDIKPLLDIGCKTVANMIKGKSPEEIRKTFNIQNDFTPEEEDQIRRENEWAEDR
InterPro domains: - IPR001232: S-phase kinase-associated protein 1-like (family) [3-110]
- IPR016073: SKP1 component, POZ domain (domain) [4-65]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [1-161]
- IPR036296: SKP1-like, dimerisation domain superfamily (homologous_superfamily) [83-158]
- IPR016897: S-phase kinase-associated protein 1 (family) [1-161]
- IPR016072: SKP1 component, dimerisation (domain) [111-158]
Interaction partners: - JmjC domain-containing histone demethylation protein 1
- Cullin-1
- Probable E3 ubiquitin ligase complex SCF subunit sconB
- Probable E3 ubiquitin ligase complex SCF subunit sconB
- RING-box protein 1
- SCF E3 ubiquitin ligase complex F-box protein grrA
- Probable E3 ubiquitin ligase complex SCF subunit sconB
- Leucine Rich Repeat domain protein
- F-box protein
- Protein phosphatase PP2A regulatory subunit B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043168 (anion binding), GO:0043295 (glutathione binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0007059 (chromosome segregation), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0044770 (cell cycle phase transition), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0044772 (mitotic cell cycle phase transition), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044839 (cell cycle G2/M phase transition), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0000086 (G2/M transition of mitotic cell cycle), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)