wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Adenosylhomocysteinase (EC 3.13.2.1) (A5PMG3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MNHGYDFPRIQFANQEDKQEFSKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPREKSQVNSKGSSDFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKVAGCTHITAQTAVLIETLVALGAQCRWTACNIYSTQNEVAAALAESGVSVFAWKGESEDDFWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPSVFKKVRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCSALKALGAIVCVTEIDPICALQACMDGFRVVKLNEVVRQMDMVITCTGNKNVVTREHLDRMKNGCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRVILLAEGRLLNLSCSTVPSFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPNFDAHLTELSDEQAKYMGLNKNGPFKPNYYRY
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [259-419]
- IPR000043: Adenosylhomocysteinase-like (family) [61-500]
- IPR042172: Adenosylhomocysteinase-like superfamily (homologous_superfamily) [61-500]
- IPR015878: S-adenosyl-L-homocysteine hydrolase, NAD binding domain (domain) [259-420]
- IPR020082: S-adenosyl-L-homocysteine hydrolase, conserved site (conserved_site) [146-298]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0000166 (nucleotide binding), GO:0043621 (protein self-association), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0017076 (purine nucleotide binding), GO:0046914 (transition metal ion binding), GO:0030554 (adenyl nucleotide binding), GO:0005507 (copper ion binding), GO:0051287 (NAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0003002 (regionalization), GO:0009953 (dorsal/ventral pattern formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: C2H2-type domain-containing protein (A0A178UA35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MSLFCNSIETLYPKPFLSHKSHFFTFSNSKFQNPKFTSFPLRHQWRIESCLKSASSSEIDMVRNKEGIFAPKEKKVVVLWDLDNKPPRGPPYEAATALRKVAEKLGRVVEISAYANRHAFIHLPHWVVEERRERRNLDFMERKGEVTPIDPYICGVCGRKCKTNLDLKKHFKQLHERERQKKVNRMRSLKGKKRQKFKERYVSGNEKYNEAARSLLTPKVGYGLEAELRRAGVYVKTVEDKPQAADWAVKRQIQHSMTRGIDWLVLVSDDKDFSDMLRKAREADLGTLVVSDMDRALGRHADLWVPWSGVEKGEIGEKDLIPGKRPRFEEDEVGFGGNDELFSLSYDEDEKAEMTVESDGFGRFNVSAFSEDEWVEDEGDFVLSDSSDDDSDDELF
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [152-180]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein TIC 22, chloroplastic (Translocon at the inner envelope membrane of chloroplasts 22) (AtTIC22) (Q9SZB2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. Imported into the intermembrane space via the Toc translocon. May be involved in the import pathway used by proteins without a cleavable N-terminal pre-sequence (By similarity).
Subcellular location: Plastid, chloroplast intermembrane space {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Sequence: MESSVKPNPFLSFSSFIHHQCTRFSSDLSARIEDTKRFAETLATRRFSLPTPPPFASVSQSKSGTPTTTLSPSLVAKALAGTSVFTVSNTNNEFVLISDPTGGKSIGLLCFRQEDAEAFLAQARLRRRELKTNAKVVPITLDQVYLLKVEGISFRFLPDPIQIKNALELKSSGNKNGFDGVPVFQSELLVVRKKNRRYCPVYFSKEDIERELSKYTRASRGDQQIMVGSLEDVLRKMEMSEKNSGWEDVIFIPPGRSYAQHMQDLIKE
InterPro domains: - IPR007378: Tic22-like (family) [6-264]
- IPR005692: Chloroplast protein import component Tic22 (family) [1-268]
Interaction partners: - Protein TIC110, chloroplastic
- Protein TIC 40, chloroplastic
- Protein TIC 55, chloroplastic
- Protein TOC75-3, chloroplastic
- Protein TIC 62, chloroplastic
- Short-chain dehydrogenase TIC 32, chloroplastic
- Protein TIC 21, chloroplastic
- Translocase of chloroplast 159, chloroplastic
- Translocase of chloroplast 34, chloroplastic
- Protein TIC 100
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0072596 (establishment of protein localization to chloroplast), GO:0009657 (plastid organization), GO:0072598 (protein localization to chloroplast), GO:0009658 (chloroplast organization), GO:0045036 (protein targeting to chloroplast)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: GOLD domain-containing protein (Q57YT0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00037847}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00037847}. Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}.
Sequence: MIVPSLNGRLFSFLFIFLTVGQLSHPSPAEAFATKIEPHSRECFVESVPAGASLAFLFRVTDGGSFDIDAVMTATTVAPLETLDDTSRLHFSEKLRPLRDNAQTTVINEWRRATEGSQTYTAPTVSETKHGLPAEVTVCFDNSFARRSPKWVSFQFLRHEGLEEDPQASMTAEAKVEAELHKHGSVLFELATATERLRLVGESDRVKHESLARIIQAGLIGNIVLLAVMAVYQYRTLTRFLLRCKPQ
InterPro domains: - IPR036598: GOLD domain superfamily (homologous_superfamily) [39-159]
- IPR009038: GOLD domain (domain) [31-242]
- IPR015720: Transmembrane emp24 domain-containing protein (family) [13-240]
Interaction partners: - GOLD domain-containing protein
- COP-coated vesicle membrane protein erv25, putative
- Cytosolic coat protein, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: PMS1 homolog 2, mismatch repair system component (A0A8I5ZND0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MEPTEGASTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATSIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIREFADLTQVETFGFRGEALSSLCALSDVTISTCHVSASIGTRLVLDHNGKIIQKTPCPRPKGTTVSVQNLFYTLPVRHKEFQRNIKKEYAKMVQVLQAYCIISAGIRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLVPFVQLPPSDSVCEEYCLSACGTPQSPFRKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFIIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMCRPSRVRQMFASRACRKSVMIGTALSASEMKKLISHMGEMDHPWNCPHGRPTMRHIANLDVISQN
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [11-231]
- IPR042121: MutL, C-terminal domain, regulatory subdomain (homologous_superfamily) [317-416]
- IPR014790: MutL, C-terminal, dimerisation (domain) [277-421]
- IPR037198: MutL, C-terminal domain superfamily (homologous_superfamily) [275-453]
- IPR014762: DNA mismatch repair, conserved site (conserved_site) [105-111]
- IPR042120: MutL, C-terminal domain, dimerisation subdomain (homologous_superfamily) [280-453]
- IPR038973: DNA mismatch repair protein MutL/Mlh/Pms-like (family) [14-251]
- IPR002099: DNA mismatch repair protein MutL/Mlh/PMS (family) [15-242]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein delta homolog 2 (DLK-2) (Endothelial cell-specific protein S-1) (Epidermal growth factor-like protein 9) (EGF-like protein 9) (Q8K1E3)
Organism: Mus musculus (Mouse)
Function: Regulates adipogenesis.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MPSGCRCLNLVCLLCILGATSQPARADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTSQSPCQNGGQCVYDGGGEYHCVCLPGFHGRGCERKAGPCEQAGFPCRNGGQCQDNQGFALNFTCRCLAGFMGAHCEVNVDDCLMRPCANGATCIDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPAPEPASVGTPQMPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQESGLGESSLVALVVFGSLTAALVLATVLLTLRAWRRGICPTGPCCYPAPHYAPARQDQECQVSMLPAGFPLSPDLPPEPGKTTAL
InterPro domains: - IPR051022: Notch Signaling and Cell Fate Determination (family) [25-262]
- IPR001881: EGF-like calcium-binding domain (domain) [89-248]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [174-236]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [189-238]
- IPR000742: EGF-like domain (domain) [25-248]
- IPR013032: EGF-like, conserved site (conserved_site) [142-166]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005112 (Notch binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0045746 (negative regulation of Notch signaling pathway), GO:0008593 (regulation of Notch signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane)
Protein: Eva-1 homolog A, regulator of programmed cell death (B8ZZF5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MKGSKSFVLQKMFSCSKNPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY
InterPro domains: - IPR039500: EVA1 domain (domain) [16-140]
- IPR052461: EVA1 A/B (family) [8-140]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0023057 (negative regulation of signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0045596 (negative regulation of cell differentiation), GO:0009966 (regulation of signal transduction), GO:0010719 (negative regulation of epithelial to mesenchymal transition), GO:0045595 (regulation of cell differentiation), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0010717 (regulation of epithelial to mesenchymal transition), GO:1902531 (regulation of intracellular signal transduction), GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway), GO:0060390 (regulation of SMAD protein signal transduction), GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen)
Protein: Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (rBR-STL) (Nervous system sulfotransferase) (NST) (P63047)
Organism: Rattus norvegicus (Rat)
Function: Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10698717}.
Sequence: MAESEAETPGTPGEFESKYFEFHGVRLPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLVDQCCNAEALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL
InterPro domains: - IPR000863: Sulfotransferase domain (domain) [45-276]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [15-284]
Interaction partners: - Sulfotransferase 1A1
- Carbohydrate sulfotransferase 10
- Cortexin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0008146 (sulfotransferase activity), GO:0004062 (aryl sulfotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006790 (sulfur compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: S-ribosylhomocysteine lyase (EC 4.4.1.21) (AI-2 synthesis protein) (Autoinducer-2 production protein LuxS) (P45578)
Organism: Escherichia coli (strain K12)
Function: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Sequence: MPLLDSFTVDHTRMEAPAVRVAKTMNTPHGDAITVFDLRFCVPNKEVMPERGIHTLEHLFAGFMRNHLNGNGVEIIDISPMGCRTGFYMSLIGTPDEQRVADAWKAAMEDVLKVQDQNQIPELNVYQCGTYQMHSLQEAQDIARSILERDVRINSNEELALPKEKLQELHI
InterPro domains: - IPR003815: S-ribosylhomocysteinase (LuxS) (family) [1-162]
- IPR011249: Metalloenzyme, LuxS/M16 peptidase-like (homologous_superfamily) [4-162]
- IPR037005: S-ribosylhomocysteinase (LuxS) superfamily (homologous_superfamily) [1-171]
Interaction partners: - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Cystathionine gamma-synthase
- Methionine synthase
- Cystathionine beta-lyase MetC
- Autoinducer-2 kinase
- Transcriptional regulator LsrR
- Cysteine synthase A
- Homocysteine S-methyltransferase
- Autoinducer 2-binding protein LsrB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0007267 (cell-cell signaling), GO:0051606 (detection of stimulus), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0009595 (detection of biotic stimulus), GO:2000145 (regulation of cell motility), GO:0009372 (quorum sensing), GO:0060245 (detection of cell density)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Single-stranded DNA-binding protein (SSB) (P66854)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
Sequence: MINNVVLVGRMTRDAELRYTPSNVAVATFTLAVNRTFKSQNGEREADFINVVMWRQQAENLANWAKKGSLIGVTGRIQTRSYDNQQGQRVYVTEVVAENFQMLESRSVREGHTGGAYSAPTANYSAPTNSVPDFSRNENPFGATNPLDISDDDLPF
InterPro domains: - IPR011344: Single-stranded DNA-binding protein (family) [1-156]
- IPR000424: Primosome PriB/single-strand DNA-binding (family) [1-104]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [1-156]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0070206 (protein trimerization), GO:0070207 (protein homotrimerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)