Protein: Sugar phosphate exchanger 3 (Q3TIT8)
Organism: Mus musculus (Mouse)
Function: Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (By similarity). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein
Sequence: MAWPRFLQRGALLTSFSHHHLAVFLLTFFSYSLLHASRKTFSNVKVSISKQWTPNAFNTSLDLPAEIWSSNHLFPSTEEATLFLGTLDTVFLFSYAVGLFISGIIGDRLNLRWVLSFGMCSSAFVVFVFGTLTEWLHFYNKWFYCGLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGAFLASSVLQYGYEYAFLVTASVQFAGGIIIFFGLLVSPEEIGLPSIGAEESSEEDSQRPLIDGAENEDDYEPNYSIQEDRAVVQVKAISFHQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLLGFISDVLQKRAPVLALSLFLAVWSLVGYSRSPNNKSINALLMTITGFFIGGPSNMVSSAISADLGRQELIQGNSEALATVTGIVDGTGSIGAAVGQYLVSLIQDNLGWMWVFYFFILMTSCTILFILPLIVREVFSLVQRRQAHSLNE
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [14-489]
- IPR011701: Major facilitator superfamily (family) [83-410]
- IPR020846: Major facilitator superfamily domain (domain) [23-480]
- IPR000849: Sugar phosphate transporter (family) [3-491]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015114 (phosphate ion transmembrane transporter activity), GO:0005452 (solute:inorganic anion antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015114 (phosphate ion transmembrane transporter activity), GO:0005452 (solute:inorganic anion antiporter activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030667 (secretory granule membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle)