Protein: Protocadherin-19 (F8W3X3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Calcium-dependent cell-adhesion protein. Essential for the early stages of neurulation in the anterior neural plate. Shows little cell adhesion activity on its own but exhibits robust homophilic cell adhesion when in a complex with cadherin cdh2 and appears to mediate the adhesion while cdh2 acts as a cell adhesion cofactor in the complex. Functions with cdh2 to coordinate cell adhesion and cell movements during neurulation. Contributes to neural progenitor cell patterning with cdh2 by promoting homophilic cell interactions. Regulates the columnar organization of neurons in the optic tectum
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence: MHSKDMDFVQMFVCFLLCWTGVDAVFNLKYTVEEELRAGTKIANVTADAKVAGFALGNRQPYLRVISNSEPRWVNLSPAGLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVNDNAPRFPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIFGLEIKTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQLNIKVIDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFINFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPAHCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDSGANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDSGYPPLRSSKSFAVKVTDENDNPPYFTKPHYQAMVLENNVPGAFLLAVSARDPDLGMNGTVSYEIIKSEVRGMSVESYVTVNSNGEIYGVRAFNHEDTRTFEFKVSAKDGGDPPLTSNATVRIVVLDVNDNTPVMTTPPLVNGTAEVSIPKNAGVGYLVTQIKADDYDEGENGRLTYSISEGDMAYFEIDQINGEVRTTKTFGENAKPSYQITVVAHDHGQTSLSASAYIVIYLSPDLNAQEQIGPVNLSLIFIIALGSIAVILFVTMIFVAVKCKRDNKEIRTYNCRVAEYSYGNQKKSSKKKKLSKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNSRNAAPNHGYHHTFTGQGPQQPDLIINGMPLPETENYSIDSSYVNSRAHLIKSTSTFKDMEGNSLKDSGHEESDQTDSEHDVQRGHYADTAVNDVLNMTVPSNNSQIPDQDQSEGFHCQDECRILGHSDRCWMPRVPIPARAKSPEHGRNVIALSIEATTVDVPHYEDCGTTKRTFATFGKDGPDEDRAEQRGRRQTAEPAVCSPKTNGAVREAGNGREAVSPITSPVHLKSPQSKASSTYNTLKCRDAERIANHSLLRQPEGKDSEPAMREINTLLQDGRDKESPGSKRLKDIVL
InterPro domains: - IPR020894: Cadherin conserved site (conserved_site) [227-561]
- IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [12-819]
- IPR002126: Cadherin-like (domain) [31-676]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [124-662]
- IPR013164: Cadherin, N-terminal (domain) [28-107]
Interaction partners: - Cadherin-2
- Sodium channel protein
- Cyclin-dependent kinase-like 5
- Nck-associated protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0003008 (system process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0009888 (tissue development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0050877 (nervous system process), GO:0035239 (tube morphogenesis), GO:0007420 (brain development), GO:0060562 (epithelial tube morphogenesis), GO:0007399 (nervous system development), GO:0021915 (neural tube development), GO:0007417 (central nervous system development), GO:0048854 (brain morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0007600 (sensory perception), GO:0009792 (embryo development ending in birth or egg hatching), GO:0072175 (epithelial tube formation), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0050953 (sensory perception of light stimulus), GO:0001841 (neural tube formation), GO:0007601 (visual perception)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)