Protein: Colony-stimulating factor 3 receptor (granulocyte) (F1R904)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MASVSLVLLLWMYIYVVIKVTGASSCGNVYTPAPVVLAGSPVSVSCSIEEDCPLTKGKVFYVQWRIDGQVVPRNYTNQESNMTYSVLIPRLQDTSASILCLVCVQEDCQIVDGVEVKNGNPPVPHNLSCALTLVKMPSLRCDWNPVQEIANLPTNYTLHLFRAKSQKVYAVPPGQHFYVVPRDAYGYFTELEISVTAANVFGNTTTDPLKLTPLNTVKFDPPSITRIEAHRYGCLKYSWSLSETQKWLQLTFIVQLRLKTVNNQPNKDLVYTSRQLQLNPIEVCSLLHWTDYRSTVRVKYYATSEWSEWSDPKTATTLNKAPAGRLDTWLKVNNQTAQLYWKPSQQFRANGQNLSYSVDSKDTKKRLCVTTETYCFFSLTKWDKKISLRARNEVGFSDHNEVPVAVHRNKGLEPVSNFSVHPQSNTSLHVIWKSPAFSNVTSYVLEWRSLCGTTAAPLSFTLIHKNKSNTTLTGLEPSKPYEISIYPRYVKGIGRPVTVLAYSSEKAPSDAPELNYEEISRSHLKFHWGQIPLEKRNGIIQGYRFYFWHNKNEIKEIMTTETSVEVKDLQPHTKYHALLSICTKGGCVNGSFSTLTTERLDGIEMVIFVIPACIGASLLVIIIVFTCFGKQERVKMCLWPIIPDPANSSIKRWTTTDSLQGLPAFKEDKDPVLVYLSHLSLLDMTEKEPFKSGYVKENQWPDDLNIHADTQSCDLELERESVPYATVLFSTPYQINSSNPPAYVRSESTQPLLAGDEPGSPPPPYENVPRGGAVSALNRFSAFSQSTQSEESDELWEEFPMLRSLEVNHI
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [26-117]
- IPR052672: Type I Cytokine Receptor Family, Type 2 Subfamily (family) [125-652]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [121-589]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [25-601]
- IPR003961: Fibronectin type III (domain) [221-603]
- IPR010457: Immunoglobulin C2-set-like, ligand-binding (domain) [25-116]
- IPR003529: Long hematopoietin receptor, Gp130 family 2, conserved site (conserved_site) [392-447]
Interaction partners: - Colony-stimulating factor 3 (granulocyte) a
- Tyrosine-protein kinase JAK1
- SI:bY184L24.2.1 (Transcription factor spi1)
- Suppressor of cytokine signaling 3
- Interferon regulatory factor 8
- Macrophage colony-stimulating factor 1 receptor
- Suppressor of cytokine signaling 3
- Plastin-2
- Interleukin 11 receptor alpha chain
- Tyrosine-protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0050793 (regulation of developmental process), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0030097 (hemopoiesis), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:0048568 (embryonic organ development), GO:0002521 (leukocyte differentiation), GO:0030099 (myeloid cell differentiation), GO:1901534 (positive regulation of hematopoietic progenitor cell differentiation), GO:0060216 (definitive hemopoiesis), GO:1903131 (mononuclear cell differentiation), GO:0002573 (myeloid leukocyte differentiation), GO:0035162 (embryonic hemopoiesis), GO:0030851 (granulocyte differentiation), GO:0030224 (monocyte differentiation), GO:0030225 (macrophage differentiation), GO:0030223 (neutrophil differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)