Protein: Forkhead box protein A2-A (FoxA2-A) (FoxA2a) (Fork head domain-related protein 3) (xFD-3) (Hepatocyte nuclear factor 3-beta homolog A) (HNF-3-beta-A) (HNF3-beta homolog A) (HNF3-beta-A) (xHNF3-beta-A) (xbeta-1) (Q91765)
Organism: Xenopus laevis (African clawed frog)
Function: Acts as a transcriptional activator during early development, limiting the extent of mesoderm formation in the gastrula. Binds to DNA via the target sequence 5'-GT[AC]AACA-3', with 5'-GTAAACA-3' being the preferred binding site.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Sequence: MLGAVKMEGHEATDWSSYYGEAEAYSSVGNMNAGLSMNPMNTYMSMSAMRTSANMTASSMNMSYVNTGMSPSLTGMSPGTGAMTGMGTGVPSMASHLSPSMIPMSAQTTAMNALAPYTNINSMSPIYGQSNINRSRDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKKPSLREGGGKKLSEGASSVGSAANSSSESSVGNESPHSSSSPCQEQKRSLVDMKSSQGLSPKHATSPASQAQHLLSQHHSVLSHEAQSHLKPEHHYSFNHPFSINNLMSSEQQHHHHHHHNHHHHHKMDLKAYEQVMHYSSYGSPMAGSLAMSTVTNKSGLESSPITSDTSYYQGGYSRPIMNSS
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [148-243]
- IPR050211: Forkhead box domain-containing protein (family) [55-401]
- IPR013638: Fork-head N-terminal (domain) [17-148]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [193-199]
- IPR018533: Forkhead box protein, C-terminal (domain) [348-423]
- IPR001766: Fork head domain (domain) [147-243]
- IPR018122: Fork head domain conserved site1 (conserved_site) [149-162]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [137-244]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0035295 (tube development), GO:0045165 (cell fate commitment), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0007492 (endoderm development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0021915 (neural tube development), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0022607 (cellular component assembly), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043009 (chordate embryonic development), GO:0042063 (gliogenesis), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0030031 (cell projection assembly), GO:0001738 (morphogenesis of a polarized epithelium), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)