Protein: Regulator of cytoskeleton and endocytosis RVS167 (Q59LF3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence
Subcellular location: Cytoplasm, cytoskeleton
Sequence: MSFKGFKKGVLRAPQTMRQKFNMGEITQDAVYLDAERRFKEIEMETKKLSEESKKYFNAVNGMLDEQIDFAKAVAEIYKPISGRLSDPSATVPEDNPQGIEASESYQAVVKDLKDTLKPDLELIEKRIVEPAQELLKIIQAIRKMSVKRDHKQLDLDRHKRNLSKYESKKERTVKDEEKMFSAQAEVEIAQQEYDYYNDLLKNELPVLFQMQSDFIKPLFVSFYYMQLNIFYTLYTRMEELKIPYFDLSTDIVEAYTAKKGNIEEQTDAIGITHFKVGHAKSKLEATKRRHAAMNSPPPTGASSIASTGTGGELPAYSPGGYNQPYGDSKYQPPSSPATYQSPVVAATAQSPATYQSPVATGQPPSYLPQTPASAPPPQVGSGLPTCTALYDYTAQAQGDLTFPAGAVIEIIQRTEDANGWWTGKYNGQTGVFPGNYVQL
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [374-439]
- IPR001452: SH3 domain (domain) [382-440]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [2-249]
- IPR004148: BAR domain (domain) [5-254]
- IPR046982: Bridging integrator 3/RVS161-like (family) [1-439]
Interaction partners: - Regulator of cytoskeleton and endocytosis RVS161
- Actin-binding protein
- Abp1p
- RVS161-like protein RVS162
- Proline-rich protein HUA1
- Actin
- Clathrin heavy chain
- Lipid-binding protein
- SH3 domain-containing protein
- Vrp1p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0005516 (calmodulin binding), GO:0008092 (cytoskeletal protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0071554 (cell wall organization or biogenesis), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:1901576 (organic substance biosynthetic process), GO:0006037 (cell wall chitin metabolic process), GO:0042546 (cell wall biogenesis), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006038 (cell wall chitin biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0006040 (amino sugar metabolic process), GO:0006022 (aminoglycan metabolic process), GO:0006030 (chitin metabolic process), GO:0046349 (amino sugar biosynthetic process), GO:1901071 (glucosamine-containing compound metabolic process), GO:0006023 (aminoglycan biosynthetic process), GO:0006031 (chitin biosynthetic process), GO:1901073 (glucosamine-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0061645 (endocytic patch), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0030479 (actin cortical patch), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030864 (cortical actin cytoskeleton), GO:0015629 (actin cytoskeleton)