wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: UDP-glycosyltransferase 89A2 (EC 2.4.1.-) (Q9LZD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glucosyltransferase that glucosylates benzoates and benzoate derivatives in vitro.
Sequence: MTEVLLLPGTKSENSKPPHIVVFPFPAQGHLLPLLDLTHQLCLRGFNVSVIVTPGNLTYLSPLLSAHPSSVTSVVFPFPPHPSLSPGVENVKDVGNSGNLPIMASLRQLREPIINWFQSHPNPPIALISDFFLGWTHDLCNQIGIPRFAFFSISFFLVSVLQFCFENIDLIKSTDPIHLLDLPRAPIFKEEHLPSIVRRSLQTPSPDLESIKDFSMNLLSYGSVFNSSEILEDDYLQYVKQRMGHDRVYVIGPLCSIGSGLKSNSGSVDPSLLSWLDGSPNGSVLYVCFGSQKALTKDQCDALALGLEKSMTRFVWVVKKDPIPDGFEDRVSGRGLVVRGWVSQLAVLRHVAVGGFLSHCGWNSVLEGITSGAVILGWPMEADQFVNARLLVEHLGVAVRVCEGGETVPDSDELGRVIAETMGEGGREVAARAEEIRRKTEAAVTEANGSSVENVQRLVKEFEKV
InterPro domains: - IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [18-448]
Interaction partners: - At1g23050
- Uncharacterized protein At5g65300
- Putative pectinesterase 63
- Putative pectinesterase/pectinesterase inhibitor 45
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042440 (pigment metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0051552 (flavone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046148 (pigment biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cysteine protease (Q9NBW3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MYLPERTEHQKIERLYDSNRVNAEPGQGLDLNEKLKPPAVYILNHEQFPQDSQLNRKGSSNDVNALRKTFESLKCRVEVISNPALPDVKNKVKEWSAKRFTQDAGFVLFILSHGDRKEKILACDHREYHLDDDVLFPLFRNPTLSGKPKILIVQACKGPLRADAKKMNNEPYIKCYSCSEGYLSYRNENHGSVFIQTLCEVMDQYGLTRDFQSIFKHVKAEVERRSTMTGSKQVPSEESHNFDKPFYFGNYAKNT
InterPro domains: - IPR011600: Peptidase C14, caspase domain (domain) [41-247]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [30-250]
- IPR002398: Peptidase C14 family (family) [164-248]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [162-250]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [37-248]
- IPR001309: Peptidase C14, p20 domain (domain) [42-160]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0008219 (cell death), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0012501 (programmed cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:0006915 (apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Endopeptidase Clp) (Q8DST7)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00444}.
Sequence: MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYINSPGGSVSAGLAIVDTMNFIKSDVQTIVMGIAASMGTIIASSGAKGKRFMLPNAEYLIHQPMGGTGGGTQQSDMAIAAEQLLKTRKKLEKILSDNSGKTIKQIHKDAERDYWMDAKETLKYGFIDEIMENNELK
InterPro domains: - IPR029045: ClpP/crotonase-like domain superfamily (homologous_superfamily) [8-194]
- IPR001907: ATP-dependent Clp protease proteolytic subunit (family) [1-193]
- IPR018215: ClpP, Ser active site (active_site) [88-99]
- IPR023562: Clp protease proteolytic subunit /Translocation-enhancing protein TepA (family) [2-193]
- IPR033135: ClpP, histidine active site (active_site) [110-123]
Interaction partners: - ATP-dependent Clp protease ATP-binding subunit ClpX
- ATP-dependent protease ClpE
- Class III stress response-related ATP-dependent Clp protease, ATP-binding subunit
- Clp-like ATP-dependent protease, ATP-binding subunit
- Chaperone protein ClpB
- Co-chaperonin GroES
- Chaperonin GroEL
- Heat-inducible transcription repressor HrcA
- Chaperone protein DnaK
- Protein GrpE
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0030163 (protein catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0005618 (cell wall), GO:0009274 (peptidoglycan-based cell wall)
Protein: NADPH-dependent aldehyde reductase 2, chloroplastic (AtChlADR2) (EC 1.1.1.-) (Short-chain type dehydrogenase/reductase) (Q9SQR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Aldehyde reductase that catalyzes the reduction of the aldehyde carbonyl groups on saturated and alpha,beta-unsaturated aldehydes with more than 5 carbons. No activity on alpha,beta-unsaturated ketones. Can use propionaldehyde, butyraldehyde, methylglyoxal, (e)-2-pentenal, (E)-2-hexenal, (Z)-3-hexenal and (E)-2-nonenal as substrates, but not propenal (acrolein), crotonaldehyde, 2-butanone, 3-buten-2-one or 1-penten-3-one.
Subcellular location: Plastid, chloroplast {ECO:0000269|PubMed:21169366}.
Sequence: MAAASSVSSPPLCLAGRVAIVTGSSRGIGRAIAIHLAELGARVVVNYSTSPVEAEKVATAITTNCSKDAEVAGKSPRVIVVKADISEPSQVKSLFDEAERVFESPVHILVNSAAIADPNHSTISDMSVELFDRIISVNTRGAFICAREAANRLKRGGGGRIILLSTSLVQTLNTNYGSYTASKAAVEAMAKILAKELKGTEITVNCVSPGPVATEMFYTGLSNEIVEKVKSQNLFGRIGETKDIAPVVGFLASDAGEWINGQVIMANGGCLL
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [16-270]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [18-269]
Interaction partners: - EMBRYO DEFECTIVE 3147
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
- 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
- Enoyl-[acyl-carrier-protein] reductase, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Beta-ketoacyl-[acyl-carrier-protein] synthase III, chloroplastic
- 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic
- AT4g13180/F17N18_70
- 3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic
- 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0046685 (response to arsenic-containing substance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Tetratricopeptide repeat domain 1 (H0YB37)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: DKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSWCLCSWCPRFWLSYVQEEAHLLRLTFLIIHTHSPAKASPEPNKPVGWETAQT
InterPro domains: - IPR052769: Tetratricopeptide repeat domain-containing protein (family) [2-112]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1-84]
- IPR019734: Tetratricopeptide repeat (repeat) [21-54]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0006605 (protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: TNF superfamily member 9 (Tumor necrosis factor ligand 5a) (Tumor necrosis factor ligand superfamily member 9) (Q80WE6)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MDQHALDVGGTVDAGHPPGTAQPPDAAFLRDTGLPSDAAFLVDTVRLTEAALPTDAACPAVNVRDPEAAWPPALNFCSRHPRLYCLGGLVLLLLVACVPIFIRILPQPALTITTSPDLDTGENTADQVTPVSHIGCANTTQQGFPVFAKLLAKNQASLSNTTLNWHSQEGAGSSYLSRGLRYEEDKKELVVDSPGLYYVFLELKLSPTSINTGRKVQGWVSLVLQAKPQVDHLDSLALTVELFPCSMEDKLVDRSWNRLLRLKAGHRLSVDLRAYLHGAQDAYRDWELSHANTTSFGLFLVKPDPPQG
InterPro domains: - IPR006052: Tumour necrosis factor domain (domain) [146-301]
- IPR021184: Tumour necrosis factor, conserved site (conserved_site) [189-205]
- IPR042373: Tumor necrosis factor ligand superfamily member 9 (family) [58-308]
- IPR008983: Tumour necrosis factor-like domain superfamily (homologous_superfamily) [138-307]
Interaction partners: - TNF receptor superfamily member 9
- Tumor necrosis factor receptor superfamily member 4
- Tumor necrosis factor ligand superfamily member 4
- CD27 antigen
- Inducible T-cell costimulator
- CD40 ligand
- CD70 antigen
- T-lymphocyte activation antigen CD80
- Tumor necrosis factor receptor superfamily, member 14
- Tumor necrosis factor receptor superfamily member 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0032813 (tumor necrosis factor receptor superfamily binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0002694 (regulation of leukocyte activation), GO:0002696 (positive regulation of leukocyte activation), GO:0042127 (regulation of cell population proliferation), GO:0050865 (regulation of cell activation), GO:0050867 (positive regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0051251 (positive regulation of lymphocyte activation), GO:0070665 (positive regulation of leukocyte proliferation), GO:0070663 (regulation of leukocyte proliferation), GO:0051249 (regulation of lymphocyte activation), GO:0032816 (positive regulation of natural killer cell activation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050670 (regulation of lymphocyte proliferation), GO:0032814 (regulation of natural killer cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0050671 (positive regulation of lymphocyte proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Uncharacterized protein Rv2627c (P9WL67)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MASSASDGTHERSAFRLSPPVLSGAMGPFMHTGLYVAQSWRDYLGQQPDKLPIARPTIALAAQAFRDEIVLLGLKARRPVSNHRVFERISQEVAAGLEFYGNRRWLEKPSGFFAQPPPLTEVAVRKVKDRRRSFYRIFFDSGFTPHPGEPGSQRWLSYTANNREYALLLRHPEPRPWLVCVHGTEMGRAPLDLAVFRAWKLHDELGLNIVMPVLPMHGPRGQGLPKGAVFPGEDVLDDVHGTAQAVWDIRRLLSWIRSQEEESLIGLNGLSLGGYIASLVASLEEGLACAILGVPVADLIELLGRHCGLRHKDPRRHTVKMAEPIGRMISPLSLTPLVPMPGRFIYAGIADRLVHPREQVTRLWEHWGKPEIVWYPGGHTGFFQSRPVRRFVQAALEQSGLLDAPRTQRDRSA
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [124-396]
Interaction partners: - Probable diacyglycerol O-acyltransferase tgs1
- Probable membrane protein Rv1733c
- Universal stress protein Rv2623
- Putative NAD
- Probable nitrate/nitrite transporter NarK2
- Uncharacterized protein Rv2030c
- Hypoxic response protein 1
- Universal stress protein Rv3134c
- Universal stress protein Rv1996
- Putative zinc metalloprotease Rip3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0004806 (triglyceride lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0006638 (neutral lipid metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0046461 (neutral lipid catabolic process), GO:0006639 (acylglycerol metabolic process), GO:0046503 (glycerolipid catabolic process), GO:0046464 (acylglycerol catabolic process), GO:0006641 (triglyceride metabolic process), GO:0019433 (triglyceride catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Acetolactate synthase small subunit (AHAS) (ALS) (EC 2.2.1.6) (Acetohydroxy-acid synthase small subunit) (Q72EF2)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Not known
Sequence: MKNTLSVLVRNQVGVVAQATEVFRQHNVNLNSISCAETEAFDVSRLMLTVEGQEHLFDAVKADLASKDFVLEVEDLSARDLVDRELALVKVAVTRETTTQVMQVCEVFRATVVGMGQETMTLEITGDMRKVDGFIRLLRPFGIRSLARTGSVALARGDD
InterPro domains: - IPR019455: Acetolactate synthase, small subunit, C-terminal (domain) [84-157]
- IPR054480: Acetolactate synthase small subunit-like, ACT domain (domain) [5-64]
- IPR002912: ACT domain (domain) [4-78]
- IPR027271: Acetolactate synthase/Transcription factor NikR, C-terminal (homologous_superfamily) [83-159]
- IPR004789: Acetolactate synthase, small subunit (family) [1-158]
- IPR045865: ACT-like domain (homologous_superfamily) [1-158]
- IPR039557: AHAS, ACT domain (domain) [3-74]
Interaction partners: - Acetolactate synthase
- Acetolactate synthase
- Thiamine pyrophosphate-requiring enzyme
- Ketol-acid reductoisomerase
- 3-isopropylmalate dehydrogenase
- acetolactate synthase
- Pyruvate:ferredoxin oxidoreductase
- Citramalate synthase
- Acetolactate synthase small subunit
- 2-isopropylmalate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0070297 (regulation of phosphorelay signal transduction system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Paralemmin-1 (Paralemmin) (A0A1D5PFN2)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Apicolateral cell membrane {ECO:0000256|ARBA:ARBA00037796}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037796}. Basolateral cell membrane {ECO:0000256|ARBA:ARBA00037871}; Lipid-anchor {ECO:0000256|ARBA:ARBA00037871}. Cell membrane {ECO:0000256|ARBA:ARBA00004342}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004342}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004342}. Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium membrane {ECO:0000256|ARBA:ARBA00004527}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004527}.
Sequence: MELRPACTGQKSMNLFAGAHETRAVEANTLQQERLQAIAEKRKRQTEIENKRRQLEDDRRQLQHLKSKALRERWLLEGAPSSASEEDEAMKKQMQEDEVKTKELEETIQRLERELESLENSSSATSTKENLAEAAAPAKEEKKENIPSVQKSPLGTAIVVHAVSAEDGALQNGAQPLSSSEVDELLHKADEVTLGEATASGDAPGSATSSQKATPRREITGLQAKPRENSTEGAEPSREQPVTMIFMGYQNVEDENETKKVLGLEGTIKAELVVIEDAESKAEPEGKDHAPPNGTALEPAAAPLQGDEVPGGQKPGTNATEAKEAEPDMDAKKQRCKCCTVM
InterPro domains: - IPR004965: Paralemmin (family) [39-298]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0030111 (regulation of Wnt signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0097060 (synaptic membrane)
Protein: Cutinase cut1 (EC 3.1.1.74) (Poly(ethylene terephthalate) hydrolase) (PET hydrolase) (PETase) (EC 3.1.1.101) (G8GER6)
Organism: Thermobifida fusca (Thermomonospora fusca)
Function: Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle (Probable). Shows esterase activity towards p-nitrophenol-linked aliphatic esters (pNP-aliphatic esters). Capable of degrading the plastic poly(ethylene terephthalate) (PET), the most abundant polyester plastic in the world.
Subcellular location: Secreted {ECO:0000269|PubMed:23604968}. Periplasm {ECO:0000269|PubMed:23604968}.
Sequence: MPPHAARPGPAQNRRGRAMAVITPRRERSSLLSRALRFTAAAATALVTAVSLAAPAHAANPYERGPNPTDALLEARSGPFSVSEERASRFGADGFGGGTIYYPRENNTYGAVAISPGYTGTQASVAWLGERIASHGFVVITIDTNTTLDQPDSRARQLNAALDYMINDASSAVRSRIDSSRLAVMGHSMGGGGTLRLASQRPDLKAAIPLTPWHLNKNWSSVRVPTLIIGADLDTIAPVLTHARPFYNSLPTSISKAYLELDGATHFAPNIPNKIIGKYSVAWLKRFVDNDTRYTQFLCPGPRDGLFGEVEEYRSTCPF
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [58-319]
- IPR041127: PET hydrolase/cutinase-like (domain) [57-318]
- IPR050261: FrsA esterase (family) [90-268]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009056 (catabolic process), GO:0006805 (xenobiotic metabolic process), GO:0010033 (response to organic substance), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0044248 (cellular catabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0071310 (cellular response to organic substance), GO:0042178 (xenobiotic catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)