Protein: Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30) (Q9BYV2)
Organism: Homo sapiens (Human)
Function: May bind and stabilize microtubules during myotubes formation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). {ECO:0000250}.
Sequence: MNFTVGFKPLLGDAHSMDNLEKQLICPICLEMFSKPVVILPCQHNLCRKCANDVFQASNPLWQSRGSTTVSSGGRFRCPSCRHEVVLDRHGVYGLQRNLLVENIIDIYKQESSRPLHSKAEQHLMCEEHEEEKINIYCLSCEVPTCSLCKVFGAHKDCEVAPLPTIYKRQKSELSDGIAMLVAGNDRVQAVITQMEEVCQTIEDNSRRQKQLLNQRFESLCAVLEERKGELLQALAREQEEKLQRVRGLIRQYGDHLEASSKLVESAIQSMEEPQMALYLQQAKELINKVGAMSKVELAGRPEPGYESMEQFTVRVEHVAEMLRTIDFQPGASGEEEEVAPDGEEGSAGPEEERPDGP
InterPro domains: - IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [42-51]
- IPR050143: Tripartite motif-containing (family) [22-343]
- IPR000315: B-box-type zinc finger (domain) [121-163]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [26-79]
- IPR017903: COS domain (domain) [271-329]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [13-114]
- IPR042752: TRIM54, RING finger, HC subclass (domain) [24-82]
- IPR033492: Tripartite motif-containing protein 54, B-box-type 2 zinc finger (domain) [124-166]
- IPR001841: Zinc finger, RING-type (domain) [26-82]
Interaction partners: - Titin
- Gamma-butyrobetaine dioxygenase
- F-box only protein 32
- Next to BRCA1 gene 1 protein
- Telethonin
- Caveolae-associated protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051129 (negative regulation of cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0043244 (regulation of protein-containing complex disassembly), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0031114 (regulation of microtubule depolymerization), GO:0007026 (negative regulation of microtubule depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:1901880 (negative regulation of protein depolymerization), GO:0051494 (negative regulation of cytoskeleton organization), GO:0031111 (negative regulation of microtubule polymerization or depolymerization), GO:1901879 (regulation of protein depolymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)