Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q9VDJ9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MEHPKTGTETALEACDYFVDEVIEASSIRDAREEVRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFLACQSGYESITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQPTVERWLPLHAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLDVVQSLLQHGANPNIVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARDDNGTAIGMAITCGDEAILSRLLARRVHPDSDYKINKKGLPTPVEVNVFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVPWMVSGVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQELFHLVSLRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPFDLWRAPKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLKQLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKHKTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVDIGTWICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQLQQLIREKFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDATLRDYYFLDPQWLCDMLAHVVTVREINPFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECIIKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQSLVGMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQRLPKMNMLCCCLVGEAIWMGDVSGNLHAYSTSTYAHLFSYMLDPNIKSAVISLVYMEKIARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAACSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIEDVKVARMCSNESHVFSCLYPGCMVYQWDVISKRIENKLDCSKLLPCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYENEIKSIITLSKDNVPLIATIGRRYRSLISRYVDSAESSTKSSAVSTPTHGAAKSVPPADVDNHIHCLLWRAKHWT
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1722-2026]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [456-915]
- IPR056602: LRRK2, beta-propeller (domain) [2113-2396]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [38-415]
- IPR032171: C-terminal of Roc, COR-A domain (domain) [1203-1316]
- IPR020859: Roc domain (domain) [919-1147]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [1878-1890]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [2123-2391]
- IPR002110: Ankyrin repeat (repeat) [76-370]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [476-878]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [925-1153]
- IPR001611: Leucine-rich repeat (repeat) [501-730]
- IPR000719: Protein kinase domain (domain) [1728-2034]
- IPR017441: Protein kinase, ATP binding site (binding_site) [1734-1761]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0051020 (GTPase binding), GO:0016301 (kinase activity), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0050793 (regulation of developmental process), GO:0051640 (organelle localization), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0061919 (process utilizing autophagic mechanism), GO:0007017 (microtubule-based process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0050773 (regulation of dendrite development), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:0060548 (negative regulation of cell death), GO:0051961 (negative regulation of nervous system development), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0060627 (regulation of vesicle-mediated transport), GO:0043170 (macromolecule metabolic process), GO:0006914 (autophagy), GO:0006793 (phosphorus metabolic process), GO:0007018 (microtubule-based movement), GO:2000026 (regulation of multicellular organismal development), GO:0046907 (intracellular transport), GO:0010941 (regulation of cell death), GO:0051656 (establishment of organelle localization), GO:0045596 (negative regulation of cell differentiation), GO:1990849 (vacuolar localization), GO:0006810 (transport), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051645 (Golgi localization), GO:0051128 (regulation of cellular component organization), GO:0030100 (regulation of endocytosis), GO:0032418 (lysosome localization), GO:1901215 (negative regulation of neuron death), GO:0010970 (transport along microtubule), GO:0031344 (regulation of cell projection organization), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0060284 (regulation of cell development), GO:1901214 (regulation of neuron death), GO:0048814 (regulation of dendrite morphogenesis), GO:0006796 (phosphate-containing compound metabolic process), GO:0051960 (regulation of nervous system development), GO:1903421 (regulation of synaptic vesicle recycling), GO:0099111 (microtubule-based transport), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0050768 (negative regulation of neurogenesis), GO:0016197 (endosomal transport), GO:0016482 (cytosolic transport), GO:0016192 (vesicle-mediated transport), GO:0031345 (negative regulation of cell projection organization), GO:0010721 (negative regulation of cell development), GO:0034330 (cell junction organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0008088 (axo-dendritic transport), GO:0006468 (protein phosphorylation), GO:0018193 (peptidyl-amino acid modification), GO:0016310 (phosphorylation), GO:1900242 (regulation of synaptic vesicle endocytosis), GO:0050767 (regulation of neurogenesis), GO:0050808 (synapse organization), GO:0042147 (retrograde transport, endosome to Golgi), GO:0018105 (peptidyl-serine phosphorylation), GO:0010975 (regulation of neuron projection development), GO:0018209 (peptidyl-serine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0031984 (organelle subcompartment), GO:0043198 (dendritic shaft), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0098791 (Golgi apparatus subcompartment), GO:0005773 (vacuole), GO:0005794 (Golgi apparatus), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005770 (late endosome), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0005774 (vacuolar membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0031902 (late endosome membrane), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)