Protein: Mannitol-1-phosphate 5-dehydrogenase (M1PDH) (MPD) (MPDH) (EC 1.1.1.17) (Q8NJJ1)
Organism: Aspergillus niger
Function: Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway. Has a strong preference for NADH over NADPH. Required for protection of conidiospores against exogenous stresses such as high temperatures and an oxidative environment.
Sequence: MGKKAIQFGGGNIGRGFVAEFLHKAGYEVVFVDVMDKMVEALQQNKSYKVTEVSEEGEHTTTITNYRAINSKTHESDVIQEIATADVVTCAVGPHILKFIAPVIAKGIDARTESKPVAVIACENAIGATDTLHGFIKQHTSQDRVESLYDRAQFANSAIDRIVPQQAPNSGLDVRIEKFYEWAVEKTPFGSVGHPDIPAIHWVDNLEPYIERKLFTVNTSHATTAYFGHFRGKKMIADALEDEEIRGLVHKVLEETASLIVAKHDISEEEQKEYVKKIVSRISNPYLEDKVERVGRAPLRKLSRKERFIGPASQLAERGMKYDSLMDAVEMALRFQNVPGDDESAELANILNEQRAEDATIHLTGLDEEHPLYPAVLERVRKVQQGTK
InterPro domains: - IPR008927: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily (homologous_superfamily) [205-386]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [3-203]
- IPR023028: Mannitol-1-phosphate 5-dehydrogenase (family) [3-380]
- IPR013131: Mannitol dehydrogenase, N-terminal (domain) [4-189]
- IPR013118: Mannitol dehydrogenase, C-terminal (domain) [205-348]
- IPR000669: Mannitol dehydrogenase (family) [5-185]
- IPR013328: 6-phosphogluconate dehydrogenase, domain 2 (homologous_superfamily) [208-384]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0000166 (nucleotide binding), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:1901265 (nucleoside phosphate binding), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0017076 (purine nucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0051287 (NAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0034599 (cellular response to oxidative stress), GO:0019400 (alditol metabolic process), GO:0062197 (cellular response to chemical stress), GO:0019751 (polyol metabolic process), GO:0034605 (cellular response to heat), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0006059 (hexitol metabolic process), GO:0046173 (polyol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)