Protein: Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)] (P16860)
Organism: Homo sapiens (Human)
Function: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
Subcellular location: [NT-proBNP]: Secreted {ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:25339504}. Note=Detected in blood. {ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:25339504}.; SUBCELLULAR LOCATION: [proBNP(3-108)]: Secreted {ECO:0000269|PubMed:17367664}. Note=Detected in blood. {ECO:0000269|PubMed:17367664}.; SUBCELLULAR LOCATION: [Brain natriuretic peptide 32]: Secreted {ECO:0000269|PubMed:17367664, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:25339504}. Note=Detected in blood. {ECO:0000269|PubMed:17367664, ECO:0000269|PubMed:18466803, ECO:0000269|PubMed:1914098, ECO:0000269|PubMed:25339504}.; SUBCELLULAR LOCATION: [BNP(3-32)]: Secreted {ECO:0000269|PubMed:17367664}. Note=Detected in blood. {ECO:0000269|PubMed:17367664}.
Sequence: MDPQTAPSRALLLLLFLHLAFLGGRSHPLGSPGSASDLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVLYTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH
InterPro domains: - IPR000663: Natriuretic peptide (family) [98-128]
- IPR002408: Natriuretic peptide, brain type (family) [11-133]
- IPR030480: Natriuretic peptide, conserved site (conserved_site) [112-128]
- IPR050787: Natriuretic Peptide Hormone (family) [1-134]
Interaction partners: - Atrial natriuretic peptide receptor 3
- Atrial natriuretic peptide receptor 1
- Natriuretic peptides A
- Atrial natriuretic peptide receptor 2
- Insulin-degrading enzyme
- C-type natriuretic peptide
- Troponin I, cardiac muscle
- C-reactive protein
- Angiotensin-converting enzyme
- Troponin T, cardiac muscle
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044057 (regulation of system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0001817 (regulation of cytokine production), GO:1901135 (carbohydrate derivative metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0002027 (regulation of heart rate), GO:0006139 (nucleobase-containing compound metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1903524 (positive regulation of blood circulation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0031323 (regulation of cellular metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0080090 (regulation of primary metabolic process), GO:0045823 (positive regulation of heart contraction), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0045823 (positive regulation of heart contraction), GO:0019438 (aromatic compound biosynthetic process), GO:0051336 (regulation of hydrolase activity), GO:0010628 (positive regulation of gene expression), GO:0090257 (regulation of muscle system process), GO:0072521 (purine-containing compound metabolic process), GO:1903522 (regulation of blood circulation), GO:0010468 (regulation of gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0043085 (positive regulation of catalytic activity), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0051174 (regulation of phosphorus metabolic process), GO:0006937 (regulation of muscle contraction), GO:0016070 (RNA metabolic process), GO:0006029 (proteoglycan metabolic process), GO:0009117 (nucleotide metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0019220 (regulation of phosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009187 (cyclic nucleotide metabolic process), GO:0052652 (cyclic purine nucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0046068 (cGMP metabolic process), GO:0009152 (purine ribonucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005576 (extracellular region), GO:1990234 (transferase complex)