Protein: P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) (P47900)
Organism: Homo sapiens (Human)
Function: Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25822790}; Multi-pass membrane protein {ECO:0000269|PubMed:25822790}.
Sequence: MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
InterPro domains: - IPR000142: P2Y purinoceptor 1 (family) [2-372]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [68-324]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [53-332]
Interaction partners: - P2Y purinoceptor 12
- Guanine nucleotide-binding protein G
- P2X purinoceptor 1
- Guanine nucleotide-binding protein G
- Ectonucleoside triphosphate diphosphohydrolase 2
- RRP15-like protein
- Ribosome biogenesis protein BOP1
- Ribosomal L1 domain-containing protein 1
- Surfeit locus protein 6
- Ribosome production factor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0097110 (scaffold protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0046983 (protein dimerization activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0043531 (ADP binding), GO:0046982 (protein heterodimerization activity), GO:0004930 (G protein-coupled receptor activity), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0001664 (G protein-coupled receptor binding), GO:0016502 (nucleotide receptor activity), GO:0005524 (ATP binding), GO:0001614 (purinergic nucleotide receptor activity), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:2000241 (regulation of reproductive process), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:2000243 (positive regulation of reproductive process), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0051047 (positive regulation of secretion), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0007631 (feeding behavior), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0023019 (signal transduction involved in regulation of gene expression), GO:0051098 (regulation of binding), GO:0051668 (localization within membrane), GO:0003013 (circulatory system process), GO:0051048 (negative regulation of secretion), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:1903531 (negative regulation of secretion by cell), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:1903530 (regulation of secretion by cell), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0030534 (adult behavior), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:1903532 (positive regulation of secretion by cell), GO:0043300 (regulation of leukocyte degranulation), GO:0097305 (response to alcohol), GO:0030030 (cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0051246 (regulation of protein metabolic process), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0006936 (muscle contraction), GO:0048545 (response to steroid hormone), GO:0030334 (regulation of cell migration), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0045744 (negative regulation of G protein-coupled receptor signaling pathway), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0050708 (regulation of protein secretion), GO:1901701 (cellular response to oxygen-containing compound), GO:0071417 (cellular response to organonitrogen compound), GO:0003018 (vascular process in circulatory system), GO:0051952 (regulation of amine transport), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0050433 (regulation of catecholamine secretion), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0017157 (regulation of exocytosis), GO:1902930 (regulation of alcohol biosynthetic process), GO:1901699 (cellular response to nitrogen compound), GO:0010676 (positive regulation of cellular carbohydrate metabolic process), GO:0010628 (positive regulation of gene expression), GO:0007600 (sensory perception), GO:0035150 (regulation of tube size), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0030518 (intracellular steroid hormone receptor signaling pathway), GO:0032870 (cellular response to hormone stimulus), GO:0006954 (inflammatory response), GO:0080164 (regulation of nitric oxide metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0050433 (regulation of catecholamine secretion), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:0014070 (response to organic cyclic compound), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:1902932 (positive regulation of alcohol biosynthetic process), GO:2000677 (regulation of transcription regulatory region DNA binding), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0009892 (negative regulation of metabolic process), GO:0043087 (regulation of GTPase activity), GO:0097746 (blood vessel diameter maintenance), GO:0035296 (regulation of tube diameter), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0051345 (positive regulation of hydrolase activity), GO:0031401 (positive regulation of protein modification process), GO:0010919 (regulation of inositol phosphate biosynthetic process), GO:0043408 (regulation of MAPK cascade), GO:0014061 (regulation of norepinephrine secretion), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0002791 (regulation of peptide secretion), GO:0071383 (cellular response to steroid hormone stimulus), GO:0031175 (neuron projection development), GO:0019233 (sensory perception of pain), GO:0072659 (protein localization to plasma membrane), GO:1903305 (regulation of regulated secretory pathway), GO:2000300 (regulation of synaptic vesicle exocytosis), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0010517 (regulation of phospholipase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0060193 (positive regulation of lipase activity), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0010518 (positive regulation of phospholipase activity), GO:1900274 (regulation of phospholipase C activity), GO:0010863 (positive regulation of phospholipase C activity), GO:0007202 (activation of phospholipase C activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)