Protein: Zinc finger protein 536 (Q8K083)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that negatively regulates neuron differentiation by repressing retinoic acid-induced gene transcription. Binds and interrupts RARA from binding to retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:19398580}.
Sequence: MEEASLCLGVSSTAPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKTPAALEEKAHVPMSGQSMGSQMALLANQLGRDVDNSLNGRVDLQQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQMKGSLLQPRSDLKPLAHAQQAPLATCNLALPPNHSVPDVAHPAPSPKPANLQEDSVTPAAGFRCTFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGPNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPTEPEVAVPMGGLSQEAHANLYSRYLSCLQSGFMAPDKASLNEPSQLYGKGELPAKEKEVLGKLLSPISSMAHSVPEGDKHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHQLSRNHEDPLANTGVLFDKEKREYVLVGADGSKQKMPADLVHSTKVGNQRDLPNKLDPLEGSREFLSHGLNQTLDYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKSDEDALHVGVGLEERRGSGSDQESQSVSRSTTPGSSNVTEESGAGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRAGGVQQQALLRDRNLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQEHKDETSSKAPMFIRPDILRGAFKGLPGIDFRGGPASQQWTAGMLSSGDHSGQATGMPSELSSDALKGSDLPSKSSHYSEIGRAYQNIVSNGVNFQGSLQAFMDSFVLSSLKKKDTKDKVPSDAHPMKAHTAEGGEEKASMKPSQRKSEKSQYEPLDLSVRPDAPTLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGRAKRKDHPTGVTVNCKEQGREASKVSVLPSLQSNKEMALPSAVGVLDSAPEKLAQGPAKETLGDPKSGQWPNHMDPAFCTFPSDFYKQFGVYPAMVGSGAPGSCLNKNTEGKTHPDDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEDEELDTEPEMTSKPLSALSKDGSSEGGDSLLSPGAPQPIQGLVSPLAQAAEEQWHSPGLLPAQDPSAGLPKPERGPPGLEKPMSMLSVLRAYSADGLAAFNGLASSTANSGCIKRPDLCGKF
InterPro domains: - IPR051967: Krueppel C2H2-type Zinc-Finger Domain-Containing Protein (family) [56-1296]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [128-803]
- IPR013087: Zinc finger C2H2-type (domain) [130-1025]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001217 (DNA-binding transcription repressor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)