Protein: H2-O alpha (Histocompatibility 2, O region alpha locus) (Q9QWV1)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MVLFVELVPVLLTAMSFLSPRGVRAIKADHMGSYGPAFYQSYDASGQFTHEFDGEQIFSVDLKNEEVVWRLPEFGDFAHSDFQSGLMSISMIKAHLDILVERSNRTRAVSVPPRVTVLPKTRVELGKPNVLICIVDDIFPPVINVTWLRNSQPITKGVAQTSFYSQPNHRFRKFHYLTFVPSAEDVYDCKVEHWGLDTPLLQHWEPQVLTPPPDTIETLICGLGLVLGLMGCLLGTVLMITGTRRPSIRR
InterPro domains: - IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [29-108]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [110-207]
- IPR050160: Major Histocompatibility Complex/Immunoglobulin (family) [15-242]
- IPR014745: MHC class II, alpha/beta chain, N-terminal (homologous_superfamily) [28-107]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [109-221]
- IPR007110: Immunoglobulin-like domain (domain) [113-193]
- IPR001003: MHC class II, alpha chain, N-terminal (domain) [29-110]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [187-193]
- IPR003597: Immunoglobulin C1-set (domain) [115-199]
Interaction partners: - Class II histocompatibility antigen, M alpha chain
- Histocompatibility 2, O region beta locus
- H-2 class II histocompatibility antigen gamma chain
- H2-M beta 2
- T-cell surface glycoprotein CD4
- Class II histocompatibility antigen, M beta 1 chain
- H-2 class II histocompatibility antigen, E-B beta chain
- H-2 class II histocompatibility antigen, A beta chain
- T-cell surface glycoprotein CD3 zeta chain
- Histocompatibility 2, M region locus 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003823 (antigen binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0042605 (peptide antigen binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0002682 (regulation of immune system process), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0019882 (antigen processing and presentation), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0002694 (regulation of leukocyte activation), GO:1903706 (regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0019884 (antigen processing and presentation of exogenous antigen), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0050865 (regulation of cell activation), GO:0002504 (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II), GO:1902105 (regulation of leukocyte differentiation), GO:0002495 (antigen processing and presentation of peptide antigen via MHC class II), GO:0002478 (antigen processing and presentation of exogenous peptide antigen), GO:0060284 (regulation of cell development), GO:0051249 (regulation of lymphocyte activation), GO:0045619 (regulation of lymphocyte differentiation), GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II), GO:0050863 (regulation of T cell activation), GO:0045580 (regulation of T cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)