Protein: POU domain, class 2, transcription factor 3 (Epoc-1) (Octamer-binding protein 11) (Oct-11) (Octamer-binding transcription factor 11) (OTF-11) (P31362)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation. The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:9242494}.
Sequence: MVNLEPMHTEIKMSGDVADSTDTRSTFGQVEPGNDRNGLDFNRQIKTEDLGDSLQQTLSHRPCHLSQGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQSVSQFLLSQTPPGQQGLQPNLLSFPQQQSTLLLPQTGPGLASQAVGRPGLSGSSLEPHLDAPQHLPGPKHLPGPGGNDEPTDLEELEKFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSASTPSSYPTLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPVKPPIYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQNNSKAAMNSSSSSSFNSSGSWYRWNHPTYLH
InterPro domains: - IPR000972: Octamer-binding transcription factor (family) [79-187]
- IPR001356: Homeodomain (domain) [272-336]
- IPR013847: POU domain (domain) [195-323]
- IPR000327: POU-specific domain (domain) [176-250]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [252-333]
- IPR017970: Homeobox, conserved site (conserved_site) [307-330]
- IPR010982: Lambda repressor-like, DNA-binding domain superfamily (homologous_superfamily) [176-250]
- IPR050255: POU domain transcription factor (family) [58-341]
Interaction partners: - POU domain, class 2, transcription factor 2
- Transient receptor potential cation channel subfamily M member 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0061061 (muscle structure development), GO:0048513 (animal organ development), GO:0007517 (muscle organ development), GO:0060537 (muscle tissue development), GO:0035914 (skeletal muscle cell differentiation), GO:0060538 (skeletal muscle organ development), GO:0007519 (skeletal muscle tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)