Protein: Serine/threonine-protein kinase pelle (EC 2.7.11.1) (Q05652)
Organism: Drosophila melanogaster (Fruit fly)
Function: Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll.
Subcellular location: Cell membrane {ECO:0000269|PubMed:7635064}. Cytoplasm {ECO:0000269|PubMed:7635064}. Note=Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei.
Sequence: MSGVQTAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQLCAHLDALDVWQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRFEPFVTD
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [194-495]
- IPR037924: Pelle, death domain (domain) [32-128]
- IPR000719: Protein kinase domain (domain) [213-499]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [29-129]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [342-354]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [217-494]
- IPR017441: Protein kinase, ATP binding site (binding_site) [219-240]
- IPR052059: Cysteine-rich Ser/Thr receptor-like kinase (family) [118-494]
- IPR000488: Death domain (domain) [28-121]
Interaction partners: - Protein Tube
- GH01161p
- LD20892p
- Protein pellino
- NF-kappa-B inhibitor cactus
- LD40663p
- Protein toll
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Embryonic polarity protein dorsal
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0005102 (signaling receptor binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0005126 (cytokine receptor binding), GO:0070851 (growth factor receptor binding), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0009967 (positive regulation of signal transduction), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0030522 (intracellular receptor signaling pathway), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0002218 (activation of innate immune response), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0031349 (positive regulation of defense response), GO:0031347 (regulation of defense response), GO:0034097 (response to cytokine), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0002753 (cytosolic pattern recognition receptor signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0019221 (cytokine-mediated signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0002221 (pattern recognition receptor signaling pathway), GO:0070555 (response to interleukin-1), GO:0043410 (positive regulation of MAPK cascade), GO:0071346 (cellular response to type II interferon), GO:0071345 (cellular response to cytokine stimulus), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0071347 (cellular response to interleukin-1), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)