Protein: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 (Complex I-B17) (CI-B17) (NADH-ubiquinone oxidoreductase B17 subunit) (Q3UIU2)
Organism: Mus musculus (Mouse)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000255}; Matrix side {ECO:0000269|PubMed:38575788}.
Sequence: MSGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPRRMWPLERFWDNFLRDGAVWKNMVFKAYRSSLFAVSHVLIPMWFVHYYVKYHMATKPYTIVSSKPRIFPGDTILETGEVIPPMRDFPDQHH
InterPro domains: - IPR019174: NADH dehydrogenase 1, beta subcomplex, subunit 6 (family) [1-128]
Interaction partners: - NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 10
- NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase flavoprotein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 5
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0022804 (active transmembrane transporter activity), GO:0008137 (NADH dehydrogenase (ubiquinone) activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0006091 (generation of precursor metabolites and energy), GO:0043933 (protein-containing complex organization), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0006996 (organelle organization), GO:0022900 (electron transport chain), GO:0022607 (cellular component assembly), GO:0007005 (mitochondrion organization), GO:0045333 (cellular respiration), GO:0065003 (protein-containing complex assembly), GO:0022904 (respiratory electron transport chain), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0042773 (ATP synthesis coupled electron transport), GO:0032981 (mitochondrial respiratory chain complex I assembly), GO:0006119 (oxidative phosphorylation), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)