Protein: Receptor for retinol uptake stra6 (F1RAX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol- binding protein rbp1. Required for normal vitamin A homeostasis
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MSAETVNNYDYSDWYENAAPTKAPVEVIPPCDPTADEGLFHICIAAISLVVMLVLAILARRQKLSDNQRGLTGLLSPVNFLDHTQHKGLAVAVYGVLFCKLVGMVLSHHPLPFTKEVANKEFWMILALLYYPALYYPLLACGTLHNKVGYVLGSLLSWTHFGILVWQKVDCPKTPQIYKYYALFGSLPQIACLAFLSFQYPLLLFKGLQNTETANASEDLSSSYYRDYVKKILKKKKPTKISSSTSKPKLFDRLRDAVKSYIYTPEDVFRFPLKLAISVVVAFIALYQMALLLISGVLPTLHIVRRGVDENIAFLLAGFNIILSNDRQEVVRIVVYYLWCVEICYVSAVTLSCLVNLLMLMRSMVLHRSNLKGLYRGDSLNVFNCHRSIRPSRPALVCWMGFTSYQAAFLCLGMAIQTLVFFICILFAVFLIIIPILWGTNLMLFHIIGNLWPFWLTLVLAALIQHVASRFLFIRKDGGTRDLNNRGSLFLLSYILFLVNVMIGVVLGIWRVVITALFNIVHLGRLDISLLNRNVEAFDPGYRCYSHYLKIEVSQSHPVMKAFCGLLLQSSGQDGLSAQRIRDAEEGIQLVQQEKKQNKVSNAKRARAHWQLLYTLVNNPSLVGSRKHFQCQSSESFINGALSRTSKEGSKKDGSVNEPSKEAESAAASN
InterPro domains: - IPR026612: Receptor for retinol uptake STRA6-like (family) [29-628]
Interaction partners: - Plasma retinol-binding protein II
- Calmodulin
- Transthyretin
- Aldehyde dehydrogenase 1 family member A3
- Retinol dehydrogenase 10-B
- Cytochrome P450 26A1
- Short-chain dehydrogenase/reductase 3
- Cytochrome P450 26B1
- Retinol-binding protein 1, cellular, tandem duplicate 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005319 (lipid transporter activity), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035265 (organ growth), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044403 (biological process involved in symbiotic interaction), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0010171 (body morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0044085 (cellular component biogenesis), GO:0035148 (tube formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0009790 (embryo development), GO:0060041 (retina development in camera-type eye), GO:0035295 (tube development), GO:0048840 (otolith development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0048839 (inner ear development), GO:0071696 (ectodermal placode development), GO:0071697 (ectodermal placode morphogenesis), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0009855 (determination of bilateral symmetry), GO:0060562 (epithelial tube morphogenesis), GO:0042472 (inner ear morphogenesis), GO:0048568 (embryonic organ development), GO:0042472 (inner ear morphogenesis), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0061053 (somite development), GO:0006869 (lipid transport), GO:0022008 (neurogenesis), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0003406 (retinal pigment epithelium development), GO:0003015 (heart process), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0001822 (kidney development), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0048793 (pronephros development), GO:0043009 (chordate embryonic development), GO:0007368 (determination of left/right symmetry), GO:0048592 (eye morphogenesis), GO:0030903 (notochord development), GO:0048048 (embryonic eye morphogenesis), GO:0031076 (embryonic camera-type eye development), GO:0150063 (visual system development), GO:0001947 (heart looping), GO:0042461 (photoreceptor cell development), GO:0048699 (generation of neurons), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0048596 (embryonic camera-type eye morphogenesis)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0045494 (photoreceptor cell maintenance), GO:0048871 (multicellular organismal-level homeostasis), GO:0007610 (behavior), GO:0010876 (lipid localization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0006810 (transport), GO:0007632 (visual behavior), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0060249 (anatomical structure homeostasis), GO:0006869 (lipid transport), GO:0022008 (neurogenesis), GO:0009416 (response to light stimulus), GO:0007634 (optokinetic behavior), GO:0007399 (nervous system development), GO:0035845 (photoreceptor cell outer segment organization), GO:0071702 (organic substance transport), GO:0001895 (retina homeostasis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0015850 (organic hydroxy compound transport), GO:0046864 (isoprenoid transport), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0046865 (terpenoid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)