Protein: Arylacetamide deacetylase (EC 3.1.1.3) (50 kDa microsomal esterase/N-deacetylase) (Q7M370)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity).
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
Sequence: GVKTVLLLIVGVLGAYYVYTPLPDNIEEPWRLLWVNAHMKTLTNLALFAEYLGSNIFMNTVKFLTSFQEVPPTSDENVTVTETTFNNVPVRVYVPKRKSKTLRRGLFYIHGGGWCVGSAALSGYDLLSRRTADRLDVVVVSTNYRLAPEYHFPIQFEDVYDALKWFLRQDVLEKYGVDPERVGVSGDSAGGNLAAAVAQQLIKDPDVKIKLKTQSLIYPALQTLDMDLPSYRENAQFPILSKSFMVRLWSEYFTSDRSLEKAMLLNQHVPVESSHLFKFTNWSSLLPEKFKKGHVYNTPTYGSSELARKYPGFLDVRAAPLLADDAQLRGFPLTYVITCQYDVLRDDGVMYVTRLRNAGVQVTHNHIEDGFHGALSYNGFKTGYRVEKQYFEWLRENV
InterPro domains: - IPR017157: Arylacetamide deacetylase (family) [1-398]
- IPR033140: Lipase, GDXG, putative serine active site (active_site) [182-194]
- IPR050300: GDXG lipolytic enzyme (family) [67-396]
- IPR013094: Alpha/beta hydrolase fold-3 (domain) [106-374]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [56-398]
Interaction partners: - B1 bradykinin receptor
- B2 bradykinin receptor
- Carboxylic ester hydrolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0004806 (triglyceride lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0042445 (hormone metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0006629 (lipid metabolic process), GO:0010817 (regulation of hormone levels), GO:0120254 (olefinic compound metabolic process), GO:0042572 (retinol metabolic process), GO:0034308 (primary alcohol metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)