Protein: Annexin (Q5T3N1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004221}. Basolateral cell membrane {ECO:0000256|ARBA:ARBA00004187}. Cell membrane {ECO:0000256|ARBA:ARBA00004296}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004296}; Extracellular side {ECO:0000256|ARBA:ARBA00004296}. Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Cell projection, phagocytic cup {ECO:0000256|ARBA:ARBA00004231}. Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004284}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000256|ARBA:ARBA00004263}. Endosome membrane {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004481}. Lateral cell membrane {ECO:0000256|ARBA:ARBA00004124}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Sequence: MNLILRYTFSKMAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFG
InterPro domains: - IPR037104: Annexin superfamily (homologous_superfamily) [19-202]
- IPR018252: Annexin repeat, conserved site (conserved_site) [70-194]
- IPR001464: Annexin (family) [67-155]
- IPR002388: Annexin A1 (family) [13-104]
- IPR018502: Annexin repeat (repeat) [53-196]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0048306 (calcium-dependent protein binding), GO:0005102 (signaling receptor binding), GO:0005543 (phospholipid binding), GO:0043169 (cation binding), GO:0050839 (cell adhesion molecule binding), GO:0004857 (enzyme inhibitor activity), GO:0045296 (cadherin binding), GO:0005544 (calcium-dependent phospholipid binding), GO:0098631 (cell adhesion mediator activity), GO:0046872 (metal ion binding), GO:0098632 (cell-cell adhesion mediator activity), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0001775 (cell activation), GO:0051051 (negative regulation of transport), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0002685 (regulation of leukocyte migration), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:1903706 (regulation of hemopoiesis), GO:0001817 (regulation of cytokine production), GO:0009725 (response to hormone), GO:0046649 (lymphocyte activation), GO:0051048 (negative regulation of secretion), GO:0010632 (regulation of epithelial cell migration), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0007162 (negative regulation of cell adhesion), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:1903531 (negative regulation of secretion by cell), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0097529 (myeloid leukocyte migration), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0050920 (regulation of chemotaxis), GO:0006952 (defense response), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0030522 (intracellular receptor signaling pathway), GO:0030307 (positive regulation of cell growth), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0050867 (positive regulation of cell activation), GO:0002687 (positive regulation of leukocyte migration), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0002274 (myeloid leukocyte activation), GO:0080090 (regulation of primary metabolic process), GO:0050921 (positive regulation of chemotaxis), GO:0071621 (granulocyte chemotaxis), GO:0031347 (regulation of defense response), GO:0032535 (regulation of cellular component size), GO:0045089 (positive regulation of innate immune response), GO:0043254 (regulation of protein-containing complex assembly), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022409 (positive regulation of cell-cell adhesion), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0022407 (regulation of cell-cell adhesion), GO:0048545 (response to steroid hormone), GO:0071702 (organic substance transport), GO:0030334 (regulation of cell migration), GO:0070663 (regulation of leukocyte proliferation), GO:0001773 (myeloid dendritic cell activation), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0045637 (regulation of myeloid cell differentiation), GO:0045639 (positive regulation of myeloid cell differentiation), GO:0098657 (import into cell), GO:0051251 (positive regulation of lymphocyte activation), GO:0010594 (regulation of endothelial cell migration), GO:0050729 (positive regulation of inflammatory response), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:1902105 (regulation of leukocyte differentiation), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0070665 (positive regulation of leukocyte proliferation), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0032717 (negative regulation of interleukin-8 production), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0042113 (B cell activation), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0022604 (regulation of cell morphogenesis), GO:0002521 (leukocyte differentiation), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0002521 (leukocyte differentiation), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0043068 (positive regulation of programmed cell death), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0042116 (macrophage activation), GO:2001235 (positive regulation of apoptotic signaling pathway), GO:0010628 (positive regulation of gene expression), GO:0036230 (granulocyte activation), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0030099 (myeloid cell differentiation), GO:0060326 (cell chemotaxis), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0050764 (regulation of phagocytosis), GO:0006954 (inflammatory response), GO:0050727 (regulation of inflammatory response), GO:0031346 (positive regulation of cell projection organization), GO:1902107 (positive regulation of leukocyte differentiation), GO:0031326 (regulation of cellular biosynthetic process), GO:0010634 (positive regulation of epithelial cell migration), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0032653 (regulation of interleukin-10 production), GO:0051046 (regulation of secretion), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:0034341 (response to type II interferon), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0051253 (negative regulation of RNA metabolic process), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0042981 (regulation of apoptotic process), GO:0050670 (regulation of lymphocyte proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005654 (nucleoplasm), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0012505 (endomembrane system), GO:0005615 (extracellular space), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0099080 (supramolecular complex), GO:0019897 (extrinsic component of plasma membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0031012 (extracellular matrix), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0009897 (external side of plasma membrane), GO:0043233 (organelle lumen), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030055 (cell-substrate junction), GO:0001533 (cornified envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0005911 (cell-cell junction), GO:0005925 (focal adhesion), GO:0099513 (polymeric cytoskeletal fiber), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005912 (adherens junction), GO:0015629 (actin cytoskeleton), GO:0005884 (actin filament)