Protein: Large ribosomal subunit protein eL39-like (Q9CQD0)
Organism: Mus musculus (Mouse)
Function: Male germ cell-specific component of the ribosome, which is required for the formation of sperm and male fertility. Replaces the RPL39 paralog in the ribosome of male germ cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The male germ cell- specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome. It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm
Subcellular location: Cytoplasm
Sequence: MASHKTFRIKRFLAKKQKQNRPIPQWIQMKTGNKIMYNSKRRHWRRTKLGL
InterPro domains: - IPR000077: Large ribosomal subunit protein eL39 (family) [1-51]
- IPR020083: Large ribosomal subunit protein eL39, conserved site (conserved_site) [30-46]
- IPR023626: Large ribosomal subunit protein eL39 domain superfamily (homologous_superfamily) [1-51]
Interaction partners: - Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL37
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein eL15
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0019222 (regulation of metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0035092 (sperm DNA condensation), GO:0048515 (spermatid differentiation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007289 (spermatid nucleus differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0007283 (spermatogenesis), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0006325 (chromatin organization), GO:0010628 (positive regulation of gene expression), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0010468 (regulation of gene expression), GO:0006997 (nucleus organization), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1903317 (regulation of protein maturation), GO:1903319 (positive regulation of protein maturation), GO:0070613 (regulation of protein processing), GO:0010954 (positive regulation of protein processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)