Protein: Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) (Q96CW5)
Organism: Homo sapiens (Human)
Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.
Sequence: MATPDQKSPNVLLQNLCCRILGRSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKKELIRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRRQPSKVSSYATLFAQALPRDAHSTPYYYARPQTLPLSYQDRSAQSAQSSGSVGSSGISSIGLCALSGPAPAPQSLLPGQSNQAPGVGDCLRQQLGSRLAWTLTANQPSSQATTSKGVPSAVSRNMTRSRREGDTGGTMEITEAALVRDILYVFQGIDGKNIKMNNTENCYKVEGKANLSRSLRDTAVRLSELGWLHNKIRRYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLGLESSLTLRRLLVWTYDPKIRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYMRSLVQHILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYTLRKSMIPSFMTMDQSRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAAYFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNLTGILETAVRATNAQFDSPEILRRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIRKGHMCNAKLLRNMPEFSGVLHQCHILASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHEVFLDTIISRCLLDSDSRALLNQLRAVFDQIIELQNAQDAIYRAALEELQRRLQFEEKKKQREIEGQWGVTAAEEEEENKRIGEFKESIPKMCSQLRILTHFYQGIVQQFLVLLTTSSDESLRFLSFRLDFNEHYKAREPRLRVSLGTRGRRSSHT
InterPro domains: - IPR040457: Gamma tubulin complex component, C-terminal (domain) [555-886]
- IPR042241: Gamma-tubulin complex component, C-terminal domain superfamily (homologous_superfamily) [555-885]
- IPR041470: Gamma tubulin complex component protein, N-terminal (domain) [251-552]
- IPR007259: Gamma-tubulin complex component protein (family) [60-888]
Interaction partners: - Mitotic-spindle organizing protein 1
- Gamma-tubulin complex component 5
- Gamma-tubulin complex component 4
- Gamma-tubulin complex component 6
- Tubulin gamma-1 chain
- Gamma-tubulin complex component 2
- Tubulin gamma-2 chain
- Mitotic spindle organizing protein 2B
- Protein NEDD1
- Actin, cytoplasmic 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0031109 (microtubule polymerization or depolymerization), GO:0007020 (microtubule nucleation), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0046785 (microtubule polymerization), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000930 (gamma-tubulin complex), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0000922 (spindle pole), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0099080 (supramolecular complex), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0099081 (supramolecular polymer), GO:0043227 (membrane-bounded organelle), GO:0055037 (recycling endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0031982 (vesicle), GO:0099513 (polymeric cytoskeletal fiber), GO:0097708 (intracellular vesicle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0005876 (spindle microtubule)