Protein: Taperin (A2AI08)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell projection, stereocilium {ECO:0000269|PubMed:20170899, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:35752427, ECO:0000269|PubMed:37952086}. Cell projection, microvillus {ECO:0000269|PubMed:24285636}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Cytoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Note=Localized prominently at the basal taper region of hair cell stereocilia (PubMed:20170899, PubMed:30159668, PubMed:30380417, PubMed:37952086). Forms organized ring-like structures with diameters ranging from 150 to 200 nm in the stereocilium taper region (PubMed:37952086). Detected in microvilli of inner hair cell supporting cells (PubMed:24285636). Predominantly nuclear in non-stereocilium cells but can shuttle between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q4KMQ1, ECO:0000269|PubMed:20170899, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:37952086}.
Sequence: MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQSQQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSDFRSEPALYF
InterPro domains: - IPR026671: Phostensin/Taperin (family) [2-749]
- IPR025907: Phostensin/Taperin PP1-binding domain (domain) [507-644]
- IPR025903: Phostensin/Taperin N-terminal domain (domain) [8-89]
Interaction partners: - Chloride intracellular channel protein 5
- Whirlin
- Glutaredoxin domain-containing cysteine-rich protein 1
- Glutaredoxin domain-containing cysteine-rich protein 2
- Radixin
- Rho family-interacting cell polarization regulator 2
- Unconventional myosin-VIIa
- Fascin-2
- TRIO and F-actin-binding protein
- Phosphatidylinositol phosphatase PTPRQ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0044085 (cellular component biogenesis), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0043254 (regulation of protein-containing complex assembly), GO:0034330 (cell junction organization), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0022607 (cellular component assembly), GO:0045216 (cell-cell junction organization), GO:0034329 (cell junction assembly), GO:0007043 (cell-cell junction assembly), GO:0043297 (apical junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)