Protein: Cadherin-6 (Kidney cadherin) (K-cadherin) (P97326)
Organism: Mus musculus (Mouse)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence: MRTYRYFLLLFWVGQPYPTFSNPLSKRTSGFPAKRKALELSANSRNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAVNRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHEMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPHVEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQIREDARINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLRAVDKDDPYSGHQFSFSLAPEAASSSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAMEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGMDSDKDS
InterPro domains: - IPR027397: Catenin binding domain superfamily (homologous_superfamily) [691-787]
- IPR000233: Cadherin, Y-type LIR-motif (domain) [723-782]
- IPR002126: Cadherin-like (domain) [68-610]
- IPR039808: Cadherin (family) [42-783]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [77-589]
- IPR020894: Cadherin conserved site (conserved_site) [256-486]
Interaction partners: - Catenin alpha-1
- Cadherin-2
- Cadherin-3
- Catenin beta-1
- Cadherin-20
- Cadherin-4
- Cadherin-7
- Cadherin-10
- Cadherin-11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0007155 (cell adhesion), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0098609 (cell-cell adhesion), GO:0048731 (system development), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007399 (nervous system development), GO:0034330 (cell junction organization), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0050808 (synapse organization), GO:0099560 (synaptic membrane adhesion), GO:0034329 (cell junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0005886 (plasma membrane), GO:0042734 (presynaptic membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0043005 (neuron projection), GO:0097060 (synaptic membrane), GO:0098984 (neuron to neuron synapse), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0030424 (axon), GO:0098686 (hippocampal mossy fiber to CA3 synapse)