Protein: Atrial natriuretic peptide receptor 3 (Atrial natriuretic peptide clearance receptor) (Atrial natriuretic peptide receptor type C) (ANP-C) (ANPR-C) (NPR-C) (P17342)
Organism: Homo sapiens (Human)
Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30032985}; Single-pass type I membrane protein.
Sequence: MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSVA
InterPro domains: - IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [49-436]
- IPR052612: Atrial Natriuretic Peptide Clearance Receptor (family) [42-407]
- IPR001828: Receptor, ligand binding region (domain) [73-422]
- IPR001170: Adenylyl cyclase class-4/guanylyl cyclase (family) [132-506]
Interaction partners: - Natriuretic peptides A
- Natriuretic peptides B
- C-type natriuretic peptide
- Guanylate cyclase activator 2B
- Guanylin
- Neuronal pentraxin receptor
- Guanylyl cyclase C
- Emerin
- Na
- Osteocrin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding), GO:0042802 (identical protein binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0033218 (amide binding), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009887 (animal organ morphogenesis), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0035556 (intracellular signal transduction), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0008217 (regulation of blood pressure), GO:0035107 (appendage morphogenesis), GO:0003013 (circulatory system process), GO:0007589 (body fluid secretion), GO:0003007 (heart morphogenesis), GO:0072359 (circulatory system development), GO:0000165 (MAPK cascade), GO:0048732 (gland development), GO:0046903 (secretion), GO:0035272 (exocrine system development), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0022612 (gland morphogenesis), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0007507 (heart development), GO:0019932 (second-messenger-mediated signaling), GO:0030879 (mammary gland development), GO:0007435 (salivary gland morphogenesis), GO:0030879 (mammary gland development), GO:0007595 (lactation), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:0019722 (calcium-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)