Protein: Origin recognition complex subunit 5 (PfORC5) (EC 3.6.4.-) (O96237)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Component of the origin recognition complex (ORC) that binds origins of replication.
Subcellular location: Nucleus {ECO:0000269|PubMed:18554328}. Note=During early-to mid replicating trophozoite stages, colocalizes with PCNA1 and ORC1 to distinct nuclear foci which probably are DNA replication origin sites (PubMed:18554328). Dissociates from PCNA1 during the late schizont stage (PubMed:18554328). {ECO:0000269|PubMed:18554328}.
Sequence: MYKIKNNESDINSDDCNETAQECIYGFSSPKKSRKESPIFVQNNDDTCSSNNIYEKKTCSNTSASSVKKYDKKEQSLCSDINNYNKVNIEGLKINERNYDRINNSEEETNINDDNNDDNNGDYDDDNNSDDDDDNDDNNNNDDNNNDDDEDVDDFEDIKENDEYKDPTYSDIYKEAKKCNIRCENIMNSSVNKKNLEEINESDPLNSSDNSMTSSSEESCSEESDKESDKESDKDGNLYDEELNEIIEEGYFKELIPAIPHDILQAYISCLKICGFERQVQLHRLINLLGDLRDPISVIQILGLPGMGKTKVVKNFIKLTNVPFAYVNCLMAVYQSGRSAKNVIYHTILKDLSINLLNEFNEYKKINNITNYSYDPTKLVPNHVSNTDNFFSILHKLLSFKPEDILNNKRTTENIRSPSNSNNNKKKKKEQNDSTGKNSKEECNNNEDDDDDNNKNNFNNNNSNNVRFNSNTNYYKDKLYDRSVVFILDNIRYLVRTHPDLFYALTRIHEYIKGPYNDVTKANKTTRGLCIILINRSPLPDEIFDGLPQPPTVWFDSYTSEMCKNILYRLYNSMCFESLLTYNDKDLKIYYVKHNKNEFLIKRNDVILENDVIYDIWCRYVDYIINVSYKDYKSDFHELLFICSHMWPLFIKPILDGVLEPIVENMNALQRNIDTHIRVATYNHSSHFTFELIDSVFLNENNLKNKIDLSFYSKILLVGAYLASRNLPLTDKRFFNATVKGGAFTLPKKRKGKNKNESILTLLSKSIPKNFTFIRWLCLTDCLLVCFFDEQLILNSLICQQINTLIQLGFISFSSPNNLSCLVRNSLMNGVQWSGYCGSALLNTTTNFSSLTNNIFCETNNSMTYESLDPYTKLVIQVPEETIRNISKEMKIPLDELII
InterPro domains: - IPR047088: Origin recognition complex subunit 5, C-terminal (domain) [709-896]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [267-603]
- IPR048866: ORC5, lid domain (domain) [617-661]
- IPR020796: Origin recognition complex, subunit 5 (family) [261-899]
Interaction partners: - Origin recognition complex subunit 2
- Origin recognition complex subunit 1
- DNA helicase
- ATPase AAA-type core domain-containing protein
- Origin recognition complex subunit 1
- DNA replication licensing factor MCM3
- histone acetyltransferase
- Uncharacterized protein
- Protein kinase, putative
- DNA helicase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006260 (DNA replication), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)