Protein: NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) (A2AQ99)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Apical cell membrane {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004424}.
Sequence: MLPTSPKTLVLLGALLTGPLGPAGGQDAPSLPWEVQRYDGWFNNLKYHQRGAAGSRLRRLIPANYADGVYQALEEPLLPNPRRLSDAVAKGKAGLPSVHNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDHNTGQSPSNPRDQSNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQSSLLMWMAPDPSTGRGGPQGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVVASEQFLSTMVPPGVYMRNSSCHFRKFPKEGSDSSPALRVCNSYWIRENPNLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPERFSRTDYVASSIQRGRDMGLPSYSQALLALGLEPPKNWSALNPQVEPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPRQLTTDGLPQCAPVTVIDYFEGSGAGYGVTLVAVCCFPLVSLIVAGVVAHFRNREHKMLLKKGKESLKKQPASDGVPAMEWPGPKEKSYPVTLQLLPDRSLQVLDKRFTVLRTIQLQSPQQVNLILSSNSGRRTLLLKIPKEYDLVLMFNSEEDRGAFVRLLQDLCICCTPGLHIAEVDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSSEDKSRLMFTMYDLDGNGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTKDIFKQSSACRVSFINRTPGNRVMGPSPRLYTEALQEKKQSGFLAQKFKQYKRFVENYRRHIVCVTIFSAICIGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVLHSAGHAVNVYIFSVSPLSLMACVFPNVFVNDGSKFPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYVLIIIHGSYALIQLPSFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPKTFEYKSGQWVRIACLDLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTCARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGSQMLCKKIYFIWVTRTQRQFEWLADIIREVEENDCQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKALNRSLFTGLRSITHFGRPPFELFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF
InterPro domains: - IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [1239-1338]
- IPR010255: Haem peroxidase superfamily (homologous_superfamily) [31-571]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [1236-1342]
- IPR050369: Respiratory burst oxidase/Ferric reductase (family) [822-1517]
- IPR011992: EF-hand domain pair (homologous_superfamily) [806-945]
- IPR019791: Haem peroxidase, animal-type (family) [25-583]
- IPR034821: Dual oxidase, peroxidase domain (domain) [38-594]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [1339-1517]
- IPR002048: EF-hand domain (domain) [819-919]
- IPR013121: Ferric reductase, NAD binding domain (domain) [1347-1500]
- IPR013112: FAD-binding 8 (domain) [1240-1338]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [832-880]
- IPR037120: Haem peroxidase domain superfamily, animal type (homologous_superfamily) [29-577]
- IPR013130: Ferric reductase transmembrane component-like domain (domain) [1062-1201]
Interaction partners: - Dual oxidase maturation factor 2
- Neutrophil cytosol factor 2
- Cytochrome b-245 light chain
- NADPH oxidase 1
- NAD
- Neutrophil cytosol factor 4
- Neutrophil cytosol factor 1
- Dual oxidase maturation factor 1
- NADPH oxidase 3
- NADPH oxidase organizer 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048589 (developmental growth), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0035264 (multicellular organism growth), GO:0042445 (hormone metabolic process), GO:0001503 (ossification), GO:0009566 (fertilization), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0042403 (thyroid hormone metabolic process), GO:0021984 (adenohypophysis development), GO:0009887 (animal organ morphogenesis), GO:0006575 (cellular modified amino acid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0021536 (diencephalon development), GO:0009888 (tissue development), GO:0060322 (head development), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0006725 (cellular aromatic compound metabolic process), GO:0030282 (bone mineralization), GO:0048839 (inner ear development), GO:0010817 (regulation of hormone levels), GO:0048853 (forebrain morphogenesis), GO:0035270 (endocrine system development), GO:0007420 (brain development), GO:0021983 (pituitary gland development), GO:0007399 (nervous system development), GO:0007423 (sensory organ development), GO:0048732 (gland development), GO:0031214 (biomineral tissue development), GO:0007417 (central nervous system development), GO:0048854 (brain morphogenesis), GO:0022612 (gland morphogenesis), GO:0018958 (phenol-containing compound metabolic process), GO:0030878 (thyroid gland development), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)