Protein: ETS proto-oncogene 2, transcription factor (A0A8I5ZS11)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004019}.
Sequence: MSPARPALGSPGPWEASTGHVQVGMNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEEQTLQEVPTGLDSVSHDSATCELPLLTPCSKAVMSQALKATFSGFHKEQRRLGIPKNPWLWNEQQVCQWLHWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEENSHLNAVPHWINSNTLGFGVEQAPYGMQAPSYLKDGLLDGMCPPSATPAALGSEQELQMLPKSRLNTVSVNYCSISQDFPGGNLNLLNSSSGKPKEHDSPENGGDSFESSDSLLRSWNSQSSLLDVQRVPSFESFEEDCSQSLCLSKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSGPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [372-486]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [90-194]
- IPR045688: Ets1, N-terminal flanking region of Ets domain (domain) [271-384]
- IPR000418: Ets domain (domain) [387-472]
- IPR016311: Transforming protein C-ets (family) [25-494]
- IPR003118: Pointed domain (domain) [109-194]
- IPR027276: Transforming protein C-ets-2 (family) [25-494]
- IPR046328: ETS family (family) [125-474]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [348-489]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0016922 (nuclear receptor binding), GO:0035259 (nuclear glucocorticoid receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)