Protein: GTPase LSG1-1 (AtLSG1-1) (DAR GTPase 6) (Protein YEAST LSG1 ORTHOLOG 1) (Q9SHS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTPase that might be redundant with LSG1-2 for ribosome biogenesis (Probable). Binds to 23S rRNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25319368}.
Sequence: MGKNEKTSLGRALVKHHNHMIQETKEKGKSYKDQHKKVLESVTEVSDIDAIIEQAEEAERLFAIHHDSATPVPINMDTGSSSSGITAKEWKEQRMREEALHASSLQVPRRPHWTPKMNVEKLDANEKQAFLTWRRKLASLEENEKLVLTPFEKNLDIWRQLWRVLERSDLIVMVVDARDPLFYRCPDLEAYAQEIDEHKKTMLLVNKADLLPSYVREKWAEYFSRNNILFVFWSAKAATATLEGKPLKEQWRAPDTTQKTDNPAVKVYGRDDLLDRLKLEALEIVKMRKSRGVSATSTESHCEQVVVGFVGYPNVGKSSTINALVGQKRTGVTSTPGKTKHFQTLIISEDLMLCDCPGLVFPSFSSSRYEMVASGVLPIDRMTEHLEAIKVVAELVPRHAIEDVYNISLPKPKSYEPQSRPPLASELLRTYCLSRGYVASSGLPDETRAARQILKDYIEGKLPHFAMPPEITRDDENETADDTLGAETREGSQTEKKGEEAPSLGLDQVLDDLSSFDLANGLVSSKTKQHKKSHRKQ
InterPro domains: - IPR043358: Ras GTPase GNL1-like (family) [1-533]
- IPR030378: Circularly permuted (CP)-type guanine nucleotide-binding (G) domain (domain) [158-362]
- IPR006073: GTP binding domain (domain) [307-374]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [156-389]
- IPR023179: GTP-binding protein, orthogonal bundle domain superfamily (homologous_superfamily) [368-469]
Interaction partners: - 60S ribosomal export protein NMD3
- Pescadillo homolog
- Probable rRNA-processing protein EBP2 homolog
- Eukaryotic translation initiation factor 6-2
- Ribosome biogenesis protein BOP1 homolog
- Large ribosomal subunit protein uL18y
- Ribosome biogenesis protein BRX1 homolog 2
- Large ribosomal subunit protein uL4z
- Chlorophyll synthase, chloroplastic
- ERBB-3 BINDING PROTEIN 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0043021 (ribonucleoprotein complex binding), GO:0043022 (ribosome binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0065008 (regulation of biological quality), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0048522 (positive regulation of cellular process), GO:0048316 (seed development), GO:0099402 (plant organ development), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0051049 (regulation of transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0009790 (embryo development), GO:0048608 (reproductive structure development), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0009793 (embryo development ending in seed dormancy), GO:0010817 (regulation of hormone levels), GO:0044089 (positive regulation of cellular component biogenesis), GO:0043170 (macromolecule metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0048367 (shoot system development), GO:0061458 (reproductive system development), GO:0090069 (regulation of ribosome biogenesis), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0048825 (cotyledon development), GO:0048827 (phyllome development), GO:2000012 (regulation of auxin polar transport), GO:0010154 (fruit development), GO:0010467 (gene expression), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0048366 (leaf development), GO:0034470 (ncRNA processing), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005840 (ribosome)