wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Possible dehydrogenase (O69693)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MKAVTCTNAKLEVVDRPSPAPAKGQLLLDVLRCGICGSDLHARLHCDELADVMAESGYHAFMRSNQQVVFGHEFCGEVVDYGPGTRRTPRRGTPVVAMPLLRRGNKEVHGIGLSTMAPGAYAERLVVEQSLTFPVPNGLAPEIAALTEPMAVGWHAVRRGEVGKGDVAIVIGCGPIGLAVICMLKSRGVHTVIASDFSPGRRALATACGADSVVDPVQDSPYAVAAGLGQGNRHLQSILDAFDLAVGTVERLQRLRLPWWHLWRAAEAAGAATPKRPVIFECVGVPGIIDGIIASAPLFSRVVVVGVCMGSDHIRPAMAINKEINLRFVLGYTPLEFRDTLHMLADGKVNAAPLITGTVGLPGVAAAFDALGDPEAHAKIMIDPKSNAASPQPFRVE
InterPro domains: - IPR011032: GroES-like superfamily (homologous_superfamily) [2-174]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [142-351]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [23-136]
Interaction partners: - Probable alcohol dehydrogenase adh
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:1901135 (carbohydrate derivative metabolic process), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Fatty Acid/Retinol binding protein (Q9TZ51)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MSVASLPECVKNFFPTEQLEFSSSITADEKPVLHEVFQKHSCFSQCGEMIDEVSKKHPELGKRLATVLEGNKKRLDGLSPAAVEYAKKLIHMVTTTLCSLTVGKPIDDADAKRLHQEFQSLSSEDQAALRKNNPDIKF
InterPro domains: - IPR008632: Nematode fatty acid retinoid binding (family) [4-136]
Interaction partners: - Fatty Acid/Retinol binding protein
- Uncharacterized protein
- CUB-like domain-containing protein
- CUB_2 domain-containing protein
- CUB-like domain-containing protein
- F-box domain-containing protein
- Ferritin
- VWFA domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008289 (lipid binding), GO:0001530 (lipopolysaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048609 (multicellular organismal reproductive process), GO:0032989 (cellular component morphogenesis), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0030703 (eggshell formation), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0001675 (acrosome assembly), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0016043 (cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0010256 (endomembrane system organization), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0033363 (secretory granule organization), GO:0070925 (organelle assembly), GO:0016050 (vesicle organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Uncharacterized protein Rv2576c (P9WL83)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MPAGVGNASGSVLDMTSVRTVPSAVALVTFAGAALSGVIPAIARADPVGHQVTYTVTTTSDLMANIRYMSADPPSMAAFNADSSKYMITLHTPIAGGQPLVYTATLANPSQWAIVTASGGLRVNPEFHCEIVVDGQVVVSQDGGSGVQCSTRPW
InterPro domains: - IPR016793: Uncharacterised conserved protein UCP021591 (family) [1-154]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004620 (phospholipase activity), GO:0004629 (phospholipase C activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Beta,beta-carotene 15,15'-dioxygenase (EC 1.13.11.63) (Beta-carotene dioxygenase 1) (Beta-carotene oxygenase 1) (Q9HAY6)
Organism: Homo sapiens (Human)
Function: Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9I993}.
Sequence: MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSFTIRDGEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSIVEKGKTKYVIFKIPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFGVTENYVIFLEQPFRLDILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFYTDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFAVPLHVDKNAEVGTNLIKVASTTATALKEEDGQVYCQPEFLYEGLELPRVNYAHNGKQYRYVFATGVQWSPIPTKIIKYDILTKSSLKWREDDCWPAEPLFVPAPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTELARASVDVDMHMDLHGLFITDMDWDTKKQAASEEQRDRASDCHGAPLT
InterPro domains: - IPR004294: Carotenoid oxygenase (family) [7-519]
Interaction partners: - Intestine-specific homeobox
- Retinol dehydrogenase 10
- Retinal dehydrogenase 2
- Retinaldehyde dehydrogenase 3
- Retinol dehydrogenase 12
- Aldehyde dehydrogenase 1A1
- Retinol dehydrogenase 11
- Retinol dehydrogenase 8
- Short-chain dehydrogenase/reductase 3
- Dehydrogenase/reductase SDR family member 9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016701 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen), GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: DNA polymerase III delta prime subunit (HolB) (O25829)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Not known
Sequence: MKNSNRLIYTDNLEESLEETASLFEHHIKFYTEIIEKDKKVIKTFNKDFKIEHAKEVISKAHLKHSELNAFLIAAPSYGIEAQNALLKILEEPPNNVCFIMFAKSQNHVLATIKSRLIKEDKRQKIPLKPLDLDLSKLDLKDIYAFLKNLDKENFDSRENQRERIESLLESVNRHKIPLNEQELQAFDLAIKANSSYYKLSYNLLPLLLSLLSKKKTP
InterPro domains: - IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2-134]
Interaction partners: - Protein HP_1247
- Beta sliding clamp
- DNA polymerase III subunit alpha
- DNA polymerase III epsilon subunit
- Single-stranded DNA-binding protein
- RNA pyrophosphohydrolase
- Aspartokinase
- DNA replication regulator protein HobA
- Bifunctional dihydropteroate synthase/dihydropteroate reductase
- Plasminogen-binding protein PgbB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process), GO:0045740 (positive regulation of DNA replication), GO:0006275 (regulation of DNA replication), GO:0090329 (regulation of DNA-templated DNA replication), GO:0030174 (regulation of DNA-templated DNA replication initiation), GO:0032298 (positive regulation of DNA-templated DNA replication initiation), GO:2000105 (positive regulation of DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0042575 (DNA polymerase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005634 (nucleus)
Protein: A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 14 (B2RXR8)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Sequence: MAWLRALLHCLLPWYCALCAAAGSQTPDLRLSGKLHDYVVTVPCSTDFQGRFLSHVVSAPAAPSPRSHLRVARSPLSLERETPRPGGPRQHFLYFNVTVFGKLLHLRLQPNRRLVAPGAPVEWQEDFRELFRQPLQQDCVYTGGVTGMPGAAVAISNCDGLAGLIRTDNSDYFIEPLERGQQEKEAGGRTHVVYRREAVQREWKEPHGDLHNEAFGLGDLPNVLDLVGDRLGDAERKRRHAKPGSYSIEVLLAVDDSVVRFHGREHTQNYVLTLMNIVDEIYHDESLGAHVNIALVRLIMVGYRQSLSLIERGNPARSLEQVCRWAHSQQRQDPSHTEHHDHVIFLTRQNFGPSGYAPVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLGMEHDGQGNGCDDETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFERTWPQPPELPGIDYSMDEQCRFDFGTGYHTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTNFGSCSRSCGGGVRSRSRSCDNPPPAYGGRPCSGSMFEYQICNSEDCPGPYEDFRAQQCAKRNSYYTHQDAKHSWLPYEPDSDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPFGCDKEVGSMKTDDKCGVCGGDNSHCRTVKGTLGKGSKQAAALKQVQIPAGARHIQIELLEKAPHRIAVKNQVTGSFIFNPKGKEASSRTFTALGLEWEHEAEDTKDSLRTNGPLPEAIAILVLPPAEGKPRGSLAYKYVIHEDLLPLIGSNNVLLEETDTYEWALKSWSPCSKACGGGIQFTKYGCRRRRDHHMVHRHLCDHKKRPKPIRRRCNQHSCPQPTWVTEEWGACSRSCGKLGLQTRGVQCLLPLSNGTHKAMPAKACLGNRPEAKKPCLRVPCPAQWRTGAWSQCSATCGEGIQQRQVVCRNTSSALGPCEGVKPDMVQICSLPACGGDLQNSTVKVEVQDPVTKTGYREPQSRPLTPEDRISTMEPCVRDRSVFCRMEVLDRYCTIPGYHRLCCESCIKKTSGPNASLASPPTFSTPGSLLPAPKATLEDVKSTRGPTSLEDHRQSQPTQLPDVADRISPVTQYPVTPQMLSPKAFPGNSPATPRRPPQDWTQTAMPTSEGQGQSREEPGHGGTSLPATSPVT
InterPro domains: - IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [246-447]
- IPR041645: ADAMTS, cysteine-rich domain 2 (domain) [459-528]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [244-447]
- IPR013273: ADAMTS/ADAMTS-like (family) [548-700]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [539-1009]
- IPR010294: ADAMTS/ADAMTS-like, Spacer 1 (domain) [702-816]
- IPR050439: ADAMTS and ADAMTS-like (family) [270-1080]
- IPR010909: PLAC (domain) [1046-1084]
- IPR002870: Peptidase M12B, propeptide (domain) [40-145]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [539-1008]
- IPR045371: ADAMTS/ADAMTS-like, cysteine-rich domain 3 (domain) [600-700]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0045229 (external encapsulating structure organization), GO:0043062 (extracellular structure organization), GO:0097435 (supramolecular fiber organization), GO:0030198 (extracellular matrix organization), GO:0030199 (collagen fibril organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: V-type proton ATPase subunit D (V-type proton ATPase subunit d) (Vacuolar proton pump subunit D) (Q9H3H0)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000256|ARBA:ARBA00029434}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00029434}.
Sequence: MSGKDRIEIFPSRMAQTIMKARLKGAQTGRNLLKKKSDALTLRFRQILKKIIETKMLMGEVMREAAFSLAEAKFTAGDFSTTVIQNVNKAQVKIRAKKDNVAGVTLPVFEHYHEGTDSYELTGLARGGEQLAKLKRNYAKAVELLVELASLQTSFVTLDEAIKIXNRRVNAIEHVIIPRIERTLAYIITELDEREREEFYRLKKIQEKKKILKEKSEKDLEQRRAAGEVLEPANLLAEEKDEDLLFE
InterPro domains: - IPR002699: ATPase, V1 complex, subunit D (family) [1-246]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0033365 (protein localization to organelle), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0061512 (protein localization to cilium), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0005764 (lysosome), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A6MW92)
Organism: Zea mays (Maize)
Function: Not known
Sequence: MDAAVRVPPALGNKTVTEVTPPPPPPAGEERLSDADTTASSTAAPNSSLSSASSAASLPRCSSLSRLSFDCSPSAALSSSSAAAAAAAASSPAPAPARPHRAGDAAWAAIRAASASAAAPLGPRDFRLLRRVGGGDVGTVYLCRLRAPPAPAPVCCLYAMKVVDRRVAAAKKKLEHAAAERRILRALDHPFLPTLFADFDAAPHFSCVVTEFCPGGDLHSLRHRMPNRRFPLPSARFYAAEVLLALEYLHMMGIVYRDLKPENVLIRADGHIMLTDFDLSLQCTSTPSLEPCAAPEAAAASCFPDHLFRRRRARLRRAASARRPPTTLVAEPVEARSCSFVGTHEYVAPEVARGGPHGAAVDWWALGVFLYELLHGRTPFAGADNEATLRNIARRPLSFPAAGAGDADARDLIARLLAKDPRHRLGSRRGAADVKAHPFFRGLNFALLRSSRPPVVPAASRSPLHRSQSCSAARTRASKPKPPPDTRFDLF
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [121-470]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [254-266]
- IPR000719: Protein kinase domain (domain) [126-440]
Interaction partners: - Transcription factor bHLH83
- Auxin efflux carrier component
- Flavin-containing monooxygenase
- Leucine-rich repeat receptor-like protein FASCIATED EAR2
- Leucine-rich repeat receptor-like kinase protein THICK TASSEL DWARF1
- AP2-EREBP transcription factor
- Ramosa 1
- Squamosa promoter-binding-like protein 15
- LOB transcription factor
- Floricaula/leafy-like transcription factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051302 (regulation of cell division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: S-norcoclaurine synthase 2 (PsNCS2) (EC 3.5.99.14) (Q4QTJ1)
Organism: Papaver somniferum (Opium poppy)
Function: Involved in the biosynthesis of (S)-coclaurine, the common precursor of all benzylisoquinoline alkaloids such as morphine, sanguinarine, codeine or papaverine. Condenses dopamine and 4-hydroxyphenylacetaldehyde.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21037103}; Single-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000269|PubMed:21037103}; Single-pass membrane protein {ECO:0000255}. Note=Initially localized to the endoplasmic reticulum but subsequently sorted to the vacuole. {ECO:0000269|PubMed:21037103}.
Sequence: MSKLITTEPLKSMAEVISNYVIQRESFSARNILNKNSLVKKEIRYDLEVPTSADSIWSVYSCPDIPRLLRDVLLPGVFQKLDVIEGNGGVGTVLDIVFPPGAVPRSYKEKFVNINHEKRLKEVIMIEGGYLDMGCTFYMDRIHIFEKTPNSCVIESSIIYEVKEEYAGKMAKLITTEPLESMAEVISGYVLKKRLQVFGFEIKPKLRFNLLLCLIICLVIAGGMFVAGVPL
InterPro domains: - IPR023393: START-like domain superfamily (homologous_superfamily) [29-194]
- IPR050279: Plant defense and hormone signaling protein (family) [47-190]
- IPR000916: Bet v I/Major latex protein (domain) [41-192]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009821 (alkaloid biosynthetic process), GO:0044272 (sulfur compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0009820 (alkaloid metabolic process), GO:1901378 (organic heteropentacyclic compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)