Protein: Organic cation/carnitine transporter 5 (AtOCT5) (Q9SAK7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High affinity carnitine transporter involved in the active cellular uptake of carnitine. Also transports organic cations (By similarity).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:18710496}; Multi-pass membrane protein {ECO:0000269|PubMed:18710496}.
Sequence: MADSLAPLLPTHIEEDEDTSSPLTFDKILEKSLSDFGFSQFLQIVLVGLALTFDSQQIFITVFTDAYPTWHCLDHTICNPATTDICKIPRSAWDWDGGFKGKSVISEFDLECSSSFLRSLPSSTFYVGSIVGGVVLAMIPDGSLGRKQLLFFSSFAMSLTGISIFLSSNIWIYSFLKFVIGFARSQTGTYALVLISERISTKWRPRATMVPFTLFVLGFMSLSGIAYLVRHASWKVLYLCTSIPAGIHSIFIYFFALESPRWLHLEGKNKEAIEVLKRISPANRGYLESVSSRLRPKETLEQTSSYSIKDLFIIKWAFRRVTLVMIIMFGLGMSYYGVPLAVRDIKVNIYMSEALNAMVELPTFVVTPILLEQFSRRSSVLVNCLIGGASGVLCFVMSLYGRTKIAFALELGSFFCARIGFNLMAIYLVELFPTCVRNSATMMLRQALVVGGACCPLIASLGRNVPSLSFAVFGFAMSGLGLFALLLPETKGLSLCDTMEEQEQRDQALKTSHSC
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [41-505]
- IPR005828: Major facilitator, sugar transporter-like (family) [114-496]
- IPR020846: Major facilitator superfamily domain (domain) [40-491]
Interaction partners: - Adenine nucleotide alpha hydrolases-like superfamily protein
- Protein FLX-like 2
- UDP-N-acetylglucosamine transporter ROCK1
- Mitochondrial arginine transporter BAC2
- Mitochondrial phosphate carrier protein 3, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015101 (organic cation transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015651 (quaternary ammonium group transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015173 (aromatic amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0001101 (response to acid chemical), GO:0009991 (response to extracellular stimulus), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0104004 (cellular response to environmental stimulus), GO:0009415 (response to water), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:1901700 (response to oxygen-containing compound), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0042631 (cellular response to water deprivation), GO:0071229 (cellular response to acid chemical), GO:0071462 (cellular response to water stimulus), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:1902075 (cellular response to salt), GO:0009651 (response to salt stress), GO:1901701 (cellular response to oxygen-containing compound), GO:0071472 (cellular response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0009705 (plant-type vacuole membrane)