Protein: Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein) (Q9NX95)
Organism: Homo sapiens (Human)
Function: Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.
Subcellular location: [Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes.; SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Golgi apparatus membrane; Single-pass membrane protein.
Sequence: MGPLRESKKEHRVQHHDKEISRSRIPRLILRPHMPQQQHKVSPASESPFSEEESREFNPSSSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGMVGEGSIQSSRYKKESKSGLVKPGSEADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGPHGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDCSPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIVELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFVDINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLSLEEQVTGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEGSVVVERAVQTDVVPYSPAISELIQSVLQKLQDPCPSSLASPDESEPDSMESFPESLSALVVDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLARGGVVRQYWSSSFLVDLLAVAAPVVPTVLWAFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFRIKT
InterPro domains: - IPR028197: Syntaphilin/Syntabulin (family) [211-503]
Interaction partners: - Kinesin-1 heavy chain
- Syntaxin-binding protein 5
- Protein bassoon
- Syntaxin-1A
- Synaptosomal-associated protein 25
- Syntaphilin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0051050 (positive regulation of transport), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0051656 (establishment of organelle localization), GO:0060341 (regulation of cellular localization), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0010647 (positive regulation of cell communication), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0051648 (vesicle localization), GO:0051222 (positive regulation of protein transport), GO:1903532 (positive regulation of secretion by cell), GO:0010970 (transport along microtubule), GO:0051654 (establishment of mitochondrion localization), GO:1904951 (positive regulation of establishment of protein localization), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0032880 (regulation of protein localization), GO:0006996 (organelle organization), GO:0051650 (establishment of vesicle localization), GO:0099111 (microtubule-based transport), GO:0050714 (positive regulation of protein secretion), GO:0072384 (organelle transport along microtubule), GO:0007010 (cytoskeleton organization), GO:0047496 (vesicle transport along microtubule), GO:0099518 (vesicle cytoskeletal trafficking)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)