Protein: Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI) (P39687)
Organism: Homo sapiens (Human)
Function: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A.
Subcellular location: Nucleus {ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:18180367}. Cytoplasm {ECO:0000269|PubMed:18180367}. Endoplasmic reticulum. Note=Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:18180367}.
Sequence: MEMGRRIHLELRNRTPSDVKELVLDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEELGEEERGQKRKREPEDEGEDDD
InterPro domains: - IPR045081: Acidic leucine-rich nuclear phosphoprotein 32 (family) [3-246]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [1-164]
- IPR001611: Leucine-rich repeat (repeat) [89-110]
- IPR003603: U2A'/phosphoprotein 32 family A, C-terminal (domain) [128-146]
Interaction partners: - Protein SET
- DNA repair nuclease/redox regulator APEX1
- Nucleoside diphosphate kinase A
- Exportin-1
- ELAV-like protein 1
- Prothymosin alpha
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Nuclear pore complex protein Nup214
- Granzyme A
- Ataxin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0019899 (enzyme binding), GO:0070063 (RNA polymerase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0050790 (regulation of catalytic activity), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0044093 (positive regulation of molecular function), GO:0032388 (positive regulation of intracellular transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0060341 (regulation of cellular localization), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051222 (positive regulation of protein transport), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0051246 (regulation of protein metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0051336 (regulation of hydrolase activity), GO:0070201 (regulation of establishment of protein localization), GO:0051247 (positive regulation of protein metabolic process), GO:0046824 (positive regulation of nucleocytoplasmic transport), GO:0006325 (chromatin organization), GO:0032880 (regulation of protein localization), GO:0043933 (protein-containing complex organization), GO:0043085 (positive regulation of catalytic activity), GO:0032386 (regulation of intracellular transport), GO:0022607 (cellular component assembly), GO:0006338 (chromatin remodeling), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0046827 (positive regulation of protein export from nucleus), GO:0051345 (positive regulation of hydrolase activity), GO:0052547 (regulation of peptidase activity), GO:0033157 (regulation of intracellular protein transport), GO:0006334 (nucleosome assembly), GO:0046822 (regulation of nucleocytoplasmic transport), GO:0034728 (nucleosome organization), GO:0010952 (positive regulation of peptidase activity), GO:0065004 (protein-DNA complex assembly), GO:0052548 (regulation of endopeptidase activity), GO:0046825 (regulation of protein export from nucleus), GO:0010950 (positive regulation of endopeptidase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:2001056 (positive regulation of cysteine-type endopeptidase activity), GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)