Protein: Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain] (Q63207)
Organism: Rattus norvegicus (Rat)
Function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Subcellular location: Secreted {ECO:0000250}.
Sequence: MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY
InterPro domains: - IPR050442: Peptidase S1 family, coagulation factors (family) [10-467]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [233-460]
- IPR001314: Peptidase S1A, chymotrypsin family (family) [260-422]
- IPR001881: EGF-like calcium-binding domain (domain) [86-122]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [86-110]
- IPR017857: Coagulation factor-like, Gla domain superfamily (homologous_superfamily) [41-85]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [101-112]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [270-275]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [411-422]
- IPR035972: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily (homologous_superfamily) [40-103]
- IPR000742: EGF-like domain (domain) [86-165]
- IPR012224: Peptidase S1A, coagulation factor VII/IX/X/C/Z (family) [1-475]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [145-465]
- IPR000294: Gamma-carboxyglutamic acid-rich (GLA) domain (domain) [22-86]
- IPR001254: Serine proteases, trypsin domain (domain) [231-465]
Interaction partners: - Antithrombin-III
- Prothrombin
- Tissue factor
- Tissue factor pathway inhibitor
- Coagulation factor VII
- Coagulation factor V.
- Coagulation factor IX
- von Willebrand factor
- Coagulation factor VIII
- Complement C3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0008217 (regulation of blood pressure), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0003013 (circulatory system process), GO:0051604 (protein maturation), GO:0006508 (proteolysis), GO:0008015 (blood circulation), GO:0010467 (gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)