Protein: Acyl-CoA dehydrogenase family member 11 (EC 1.3.99.-) (Q9XWZ2)
Organism: Caenorhabditis elegans
Function: Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat.
Sequence: MHRIGNAVRMASSSSANATITARHTQYSHAKTGGFSQTGPTLHNPYKDDPILDRTLRRLLPESEYMRVAADLSKFGDRITSEVEHLGRQAELEQPRLEHQDAWGKRVDKLIVCNEWHKLKQICAEEGVISIGYEDSVDPFVRRIHQVAKLFLFSPSAGLVSCPMAMTDGAVKTLTSLNLYGKHKLATEAVDRLRSRDPSKAWTSGQWMTEKKGGSDVAGGCDTYAVQIDKDTYRLHGYKWFSSAVDADVALTLARIVDSDGNALEGSRGLSLFLLKIRDESGNLNGIQMVRLKNKLGTKQLPTAELLLDGAIAERIGDQGRGVAGISNMLNITRIHNAVASLGYMRRIISLARDYSTKRVVFGQTQSKWPLHTTTLAKMEVDTRGSMLLLFEAARLLGLSEAGKSSDVEAMMLRLITPVLKLYAGKQAVPMVSEGIECFGGQGYMEDTGLPTLLRDAQVTPIWEGTTNVLSLDVLRVFSGKENILLAFGKRVEQLLGNTKTEDEKLKKSKEAVESALKQLQKLLVKASDSAIQGETRIDSVARHIAFTIARIYSGALLIDHASDSSVANQSDIEVAYRYCCEQPLIDLRWEWFASERVKADREIVFDNFTALEKSKI
InterPro domains: - IPR036250: Acyl-CoA dehydrogenase-like, C-terminal (homologous_superfamily) [327-481]
- IPR041504: Adaptive response protein AidB, N-terminal (domain) [43-195]
- IPR034184: Putative acyl-CoA dehydrogenase AidB (family) [46-480]
- IPR006091: Acyl-CoA oxidase/dehydrogenase, middle domain (domain) [206-309]
- IPR009100: Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily (homologous_superfamily) [157-330]
- IPR052904: Acyl-CoA dehydrogenase-like protein (family) [10-609]
- IPR009075: Acyl-CoA dehydrogenase/oxidase, C-terminal (domain) [320-476]
- IPR053998: Acyl-CoA dehydrogenase 11-like C-terminal domain (domain) [484-606]
Interaction partners: - Probable enoyl-CoA hydratase, mitochondrial
- 3-hydroxyacyl-CoA dehydrogenase
- Trifunctional enzyme subunit alpha, mitochondrial
- Fatty acid synthase
- 3-ketoacyl-CoA thiolase
- Delta
- Long-chain-fatty-acid--CoA ligase
- Electron transfer flavoprotein subunit beta
- Hydroxysteroid dehydrogenase-like protein 2
- Probable electron transfer flavoprotein subunit alpha, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0016634 (oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006629 (lipid metabolic process), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:1901575 (organic substance catabolic process), GO:0006631 (fatty acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0043436 (oxoacid metabolic process), GO:0030258 (lipid modification), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0019395 (fatty acid oxidation), GO:0046395 (carboxylic acid catabolic process), GO:0034440 (lipid oxidation), GO:0009062 (fatty acid catabolic process), GO:0006635 (fatty acid beta-oxidation), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)