Protein: Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70) (O15321)
Organism: Homo sapiens (Human)
Function: Plays an essential role in autophagy.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:19029833}; Multi-pass membrane protein {ECO:0000269|PubMed:19029833}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19029833}; Multi-pass membrane protein {ECO:0000269|PubMed:19029833}.
Sequence: MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD
InterPro domains: - IPR004240: Nonaspanin (TM9SF) (family) [34-606]
Interaction partners: - Charged multivesicular body protein 2a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0007155 (cell adhesion), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0140352 (export from cell), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0030155 (regulation of cell adhesion), GO:0044255 (cellular lipid metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0051668 (localization within membrane), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0045184 (establishment of protein localization), GO:0006629 (lipid metabolic process), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0051222 (positive regulation of protein transport), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0071705 (nitrogen compound transport), GO:0032386 (regulation of intracellular transport), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0009306 (protein secretion), GO:0010256 (endomembrane system organization), GO:1904951 (positive regulation of establishment of protein localization), GO:0022407 (regulation of cell-cell adhesion), GO:0070201 (regulation of establishment of protein localization), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0032880 (regulation of protein localization), GO:0045229 (external encapsulating structure organization), GO:1905477 (positive regulation of protein localization to membrane), GO:0090150 (establishment of protein localization to membrane), GO:1901566 (organonitrogen compound biosynthetic process), GO:0036211 (protein modification process), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0015031 (protein transport), GO:0006643 (membrane lipid metabolic process), GO:0072657 (protein localization to membrane), GO:0008104 (protein localization), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0042157 (lipoprotein metabolic process), GO:0006996 (organelle organization), GO:0008610 (lipid biosynthetic process), GO:0061024 (membrane organization), GO:0033365 (protein localization to organelle), GO:1905475 (regulation of protein localization to membrane), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0006493 (protein O-linked glycosylation), GO:1990778 (protein localization to cell periphery), GO:0043001 (Golgi to plasma membrane protein transport), GO:0061951 (establishment of protein localization to plasma membrane), GO:0042158 (lipoprotein biosynthetic process), GO:0006497 (protein lipidation), GO:0007029 (endoplasmic reticulum organization), GO:0071692 (protein localization to extracellular region), GO:0072659 (protein localization to plasma membrane), GO:0051205 (protein insertion into membrane), GO:0009247 (glycolipid biosynthetic process), GO:0006892 (post-Golgi vesicle-mediated transport), GO:0010975 (regulation of neuron projection development), GO:0034067 (protein localization to Golgi apparatus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)