Protein: Calcium/manganese antiporter SLC30A10 (Q3UVU3)
Organism: Mus musculus (Mouse)
Function: Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange. Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Recycling endosome membrane. Early endosome membrane; Multi-pass membrane protein. Note=Localization to the Golgi and plasma membrane is regulated by zinc
Sequence: MGRYSGKTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLGSGYIARRGPRGSSATYGYVRAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGALGLAVNVVGLLIFQDCGACFSRCTRGRRTRPSQQPSQGDPRGALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEGATVFSNVAGDSLNTENEPEETTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRREDPCNWQCYIDPSLTVVMVIIILSSAFPLIKETAVILLQMVPKGVNMEELMSQLSTVPGISSVHEVHIWELISGKIIATLHIKHQKGTEYQDASRKIREIFHHAGIHNVTIQFETLDLKEALEQKDFLLTCSAPCITQSCAKKLCCPPGTLPLALVNGCAEHNGRSSRESYRSIEAPEVAIDVDGCPREQGQTLSKTQERQHYENSTHF
InterPro domains: - IPR002524: Cation efflux (family) [10-377]
- IPR027469: Cation efflux transmembrane domain superfamily (homologous_superfamily) [5-300]
- IPR027470: Cation efflux protein, cytoplasmic domain (domain) [303-375]
- IPR058533: Cation efflux protein, transmembrane domain (domain) [12-299]
Interaction partners: - Metal cation symporter ZIP14
- Metal cation symporter ZIP8
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter 6
- Zinc transporter ZIP1
- Zinc transporter ZIP13
- Zinc transporter ZIP5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:0045184 (establishment of protein localization), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0030968 (endoplasmic reticulum unfolded protein response), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0032940 (secretion by cell), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:0009967 (positive regulation of signal transduction), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0006952 (defense response), GO:0010817 (regulation of hormone levels), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0023061 (signal release), GO:0055123 (digestive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0048880 (sensory system development), GO:0016055 (Wnt signaling pathway), GO:0090596 (sensory organ morphogenesis), GO:0071702 (organic substance transport), GO:0048732 (gland development), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0050769 (positive regulation of neurogenesis), GO:0010468 (regulation of gene expression), GO:0002063 (chondrocyte development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0002064 (epithelial cell development), GO:0031667 (response to nutrient levels), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0072001 (renal system development), GO:0034097 (response to cytokine), GO:1901215 (negative regulation of neuron death), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0071310 (cellular response to organic substance), GO:0010256 (endomembrane system organization), GO:0007423 (sensory organ development), GO:0009914 (hormone transport), GO:0046903 (secretion), GO:0010628 (positive regulation of gene expression), GO:0046903 (secretion), GO:0051960 (regulation of nervous system development), GO:0046879 (hormone secretion), GO:0048546 (digestive tract morphogenesis), GO:0030855 (epithelial cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0006954 (inflammatory response), GO:0007589 (body fluid secretion), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0048565 (digestive tract development), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0042981 (regulation of apoptotic process), GO:0048592 (eye morphogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0001656 (metanephros development), GO:0150063 (visual system development), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0042461 (photoreceptor cell development), GO:0043524 (negative regulation of neuron apoptotic process), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0043408 (regulation of MAPK cascade), GO:0019218 (regulation of steroid metabolic process), GO:0001654 (eye development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0043066 (negative regulation of apoptotic process), GO:0006355 (regulation of DNA-templated transcription), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0042886 (amide transport), GO:0015833 (peptide transport), GO:0003158 (endothelium development), GO:0006816 (calcium ion transport), GO:0006417 (regulation of translation), GO:0070301 (cellular response to hydrogen peroxide), GO:0072078 (nephron tubule morphogenesis), GO:0010608 (post-transcriptional regulation of gene expression), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045892 (negative regulation of DNA-templated transcription), GO:0030001 (metal ion transport), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0030001 (metal ion transport), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)