Protein: Peroxide stress-activated histidine kinase mak1 (EC 2.7.13.3) (His-Asp phosphorelay kinase phk3) (Mcs4-associated kinase 1) (Q9P7Q7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MRPPDDQINNNVGSNSHLEKLKEAMDHQLQKSSKIVGSFTNSQNSSVGSVHSPILESPTSLNRQHRNSFSFNNVSSPSLEDERLINFPRVNPNRLMTSKRPNELFKTSSMSSDCYSPQKSRESLNSLCHSPAPSVSSCGNALNNDNTSASHSLTDEQPFETDSSANLFKQLQEKRNRTIGNVYEMACLLVFKTGLMNFWKNIIDFFAQQFFSTQISVVEPRDLSDIYNTPWQLRCYYDGGSHYDPYSNPISVNDNLASSSYVTVVASDGSKGIIYKDPASLKHEGDLLIDSKVVQTVLERATLLVYTRKQQHIVKNTKVHDNDYFSSIPNVDDIRSIKNSWKVFHDEKLNELKKQVEISASAAQLNGLYPQKKRAFVSHFSQNRKPYSQSDISKAQSSSFSEEPSNIYDEYEQNLLSPWSRSPVASPSIQTDPNRNPFFQNCLQESSFATESSTEKSASESVSETAVNDDCKGMNFSGNRRQEDHLNDFTSFPTETAVSIVHVPLMFPCSDQTSSRGRAPIAILSFKSNLVPYPENLIASIERLIPFIFSSYSNSQSVPLLPCPTQRHLLFNTSSTDNTKELSMSASSENSDCPHKEGECVGSFCNINAKGSSLNNIPKLPRFVPVPSEFFKKNQRSWVTLKKHRLLARLKSRISKKNSKVNENLRFSLNDGENYSNETITLKKDEIVLDKSKSYACCTSESHKYVQGHCGGQAPPFPLLKVIIDSIPVHVFTADPGSGKLTWVNRKTLLYCGLNMNEQIELQFSRIHPDDLPNFLNDWKSSLFSGSGFYHEIRLQRFDNVYRYFICRAVPLRDCTGSVLHFFGTMTDVHDQKLAERELQKQSAIAANENSYRSLAEASPQIVFAANGKNGIIYANAQWLSYSGLSLESSLGLGFLSAVYHADRKKCLLPESLEGTFNNQDESNGTKTFAAEIRFRSTDGHYRWHLVKSVCVNNSADTSTNLWLGTCTDIHDHKMLEEKLQESNIEAQRIVRSKMQYLSNMSHEIRTPLIGITGMVSFLLETQMSAEQLSYARIIQQSAKSLLTVINDILDLSKVRAGMMKLTSQRFSVRAMMEDANETLGTLAFSKGIELNYTVDIDVPDIVFGDNMRMRQVALNVIGNAIKFTNVGEVFTRCSVEKIDYSTNTVVLKWECIDTGQGFNRDDQLQMFKPFSQVESSTLPRHGGSGLGLVISKELVELHNGSMSCQSRRGVGTRFMWTATFTMDKTPLKFEPPDGCCPVCFCPYEKSKQSTEDYYCADDGNDKSATNFVKLAVNKADPGRESNRRKLESDKNVQSNKYVNPFASESEFCRCGASADPYTVLFWRLYRNKPSGIKLDKSALAVVVSHTKYSSEAIGNMLQSIIDISSFKDIVRYGNTYEAFEELLENPMQSKVTHIILNLPDIEAYVLFVKSLQLCSLYKDTKFILVTSTRQKESLSKIFSDSEDCNSESIHYVLKLVKPSKFFPLFYSDSEEKGKIGALNDMTRKAAMEQKADAETLRYNLAKSGFSVLLAEDNIINIKVISRYLERIGVKFKVTMDGLQCVEEWKREKPNFYSLILMDLQMPVMDGYQACNEIRKYELENDYPKVPIVALSANALPHVVLSCKDSGFDSYLAKPITLQHLSLIISGILNYTNQSKLHK
InterPro domains: - IPR000700: PAS-associated, C-terminal (domain) [789-982]
- IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [1047-1226]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [1105-1223]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [1506-1629]
- IPR000014: PAS domain (domain) [718-980]
- IPR013655: PAS fold-3 (domain) [764-826]
- IPR036097: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (homologous_superfamily) [977-1058]
- IPR011006: CheY-like superfamily (homologous_superfamily) [1504-1631]
- IPR005467: Histidine kinase domain (domain) [1000-1223]
- IPR003661: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (domain) [992-1058]
- IPR004358: Signal transduction histidine kinase-related protein, C-terminal (domain) [1148-1201]
- IPR035965: PAS domain superfamily (homologous_superfamily) [723-970]
- IPR001610: PAC motif (repeat) [790-973]
Interaction partners: - Multistep phosphorelay regulator 1
- MAP kinase kinase kinase wis4
- Uncharacterized oxidoreductase C22A12.17c
- MAP kinase kinase kinase win1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140299 (small molecule sensor activity), GO:0000155 (phosphorelay sensor kinase activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016775 (phosphotransferase activity, nitrogenous group as acceptor), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004673 (protein histidine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)