Protein: Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1) (Q93038)
Organism: Homo sapiens (Human)
Function: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted.
Sequence: MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP
InterPro domains: - IPR011029: Death-like domain superfamily (homologous_superfamily) [329-416]
- IPR001368: TNFR/NGFR cysteine-rich region (domain) [33-115]
- IPR034050: Tumor necrosis factor receptor 25, N-terminal (domain) [32-145]
- IPR000488: Death domain (domain) [321-413]
- IPR022329: Tumour necrosis factor receptor 25 (family) [1-417]
Interaction partners: - Torsin-1A
- Tumor necrosis factor ligand superfamily member 15
- Tumor necrosis factor receptor superfamily member 10A
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Tumor necrosis factor ligand superfamily member 12
- Tumor necrosis factor ligand superfamily member 6
- Tumor necrosis factor
- Tumor necrosis factor ligand superfamily member 10
- HLA class II histocompatibility antigen DQ alpha chain
- FAS-associated death domain protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0019955 (cytokine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0012501 (programmed cell death), GO:0104004 (cellular response to environmental stimulus), GO:0010646 (regulation of cell communication), GO:0071214 (cellular response to abiotic stimulus), GO:0097190 (apoptotic signaling pathway), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0009612 (response to mechanical stimulus), GO:0071496 (cellular response to external stimulus), GO:0006915 (apoptotic process), GO:0097191 (extrinsic apoptotic signaling pathway), GO:0071260 (cellular response to mechanical stimulus), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)