Protein: Cullin-2 (A0A8M9P612)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MSLKPRVVDFDETWNKLLTTIRAVVMLDYVERATWNDRFSDIYALCVAYPEPLGEKLYTETKVFLENHVRQLFKRVLESEEKVLVMYHRYWEEYSKGAEYMDCLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMIEPLQPMLIGKLLKEIKNDRCGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFEGPFLTKTGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEVRCRKYLHPSSYSKVIHECQQRMVADHLQFLHGECQNIIRQEKRDDMANMYTLLRAVSSGLPHMIQELQVHIHDEGIRATINLSQENMPTLFVESVLEVHSKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSICKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKIYARMLAKRLIHGLSLSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSTDLNNKFNNFIKTQETVVDLGISFQIYVLQAGAWPLTHVPSSTFAIPQELEKSVQMFELFYNQHFSGRKLTWLHYLCTGEVKMNYLSKPYVAVVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELQKTIKSLLDVKMISHDLQKEEIEPESTFSLIMSFTSKRTKFKITTSMQKDTPQELEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVINQSKARFNPSISMIKKCIEVLIDKQYIERSQSSADEYSYVA
InterPro domains: - IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [10-380]
- IPR059120: Cullin-like, alpha+beta domain (domain) [511-644]
- IPR016157: Cullin, conserved site (conserved_site) [718-745]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [657-745]
- IPR045093: Cullin (family) [11-745]
- IPR019559: Cullin, neddylation domain (domain) [672-739]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [657-745]
- IPR036317: Cullin homology domain superfamily (homologous_superfamily) [382-654]
- IPR016158: Cullin homology domain (domain) [386-618]
- IPR001373: Cullin, N-terminal (domain) [14-487]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044238 (primary metabolic process), GO:0001704 (formation of primary germ layer), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0048333 (mesodermal cell differentiation), GO:0030097 (hemopoiesis), GO:0043412 (macromolecule modification), GO:0048568 (embryonic organ development), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0048332 (mesoderm morphogenesis), GO:0007498 (mesoderm development), GO:0035162 (embryonic hemopoiesis), GO:0060215 (primitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex)