Protein: Calsyntenin-3 (A0A8M9PFP2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Synaptic adhesion molecule. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with presynaptic neurexins (By similarity)
Subcellular location: Postsynaptic cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses
Sequence: MARMSFLSFLLFCLTSVAHGNKANKHKPWIETEYQGIVMENDNTVLLNPPLFALDKDAPLHYAGEICGFRVHNGPGGSGSAQFEAVVLDRSTGEGLVRSKEPLDCESQKEHSFTIQAYDCGEGPDGTNSKKSHKATVHVRVNDVNEFSPVFVERRYEASVPEGRLFDRIVRVEAVDADCSPQYSQICFYDIITPNVPFTIDNDGNIKNTEPLDSKRQRVHSFWVTAFDCGKNRAQADAQVIVTVKPSCKPGWIGWTKRIEYTPGSGSIPLFPNLHLETCEETVWNIQATVELQTSHIGKGCDRDSYSDRSVRRLCGAVRGEVDLLPPPSPATNWTAALPTLPSSDSSLVFSFNGSTHVAVVPDSVASAVSGDHFTLQLWMRRGGASTQPPANQARGTRKEEETIVCSTVKNDDSYSHYSLSVHGCRLSLFYWPDVSAARPVKFLWKLEQVCDSEWHHLSLSVQFPSVTLYVDGVTFDPALIHDNGAIPNPAPHQRLVIGACWEPEEKPKDIVNNTMPENKDTGKFVSGYKGLLSGVTVRPGNVEPHSVVECLYACREGLDFGDLETLGSGMKVHVNPSQSVLVLEGDDIESFNRAVQQVTYRNSLRFATPGVRPLKLTTSLRCFSEESCLSLRQLEGYLVVLQPDAPQISLSGVGPHLARPAAEFEGPQGVPLFPELRIVCSLSHAVNTAAQGMEGGALMSDAVAHTLDGCEVQPLGEELNTEREELLVDMESLRERGLDIINTTAYIAITGAESISVYEDVLRSIHYRLAKGSARFERRFRLSCSEMNGRYTSNELTLEVNFLHSLDSLYHPSHLLASQQQFLHPSHHTGELSGHTLPNPHRNSVVPGAATVIIMVCVGFLVVMVILGVFRIRSIHRRGEGARGGGKEGGNQWDDSALTIIVNPMETYENRMGITTDMEGECEDEEEVVDSPDDTSDDQRIIIKKEGRDSAPRRY
InterPro domains: - IPR002126: Cadherin-like (domain) [30-271]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [26-247]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [321-555]
- IPR045588: Calsyntenin, C-terminal (domain) [566-910]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007272 (ensheathment of neurons), GO:0045494 (photoreceptor cell maintenance), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051640 (organelle localization), GO:0032989 (cellular component morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0097009 (energy homeostasis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0035239 (tube morphogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0042552 (myelination), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0040007 (growth), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0051650 (establishment of vesicle localization), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0045211 (postsynaptic membrane), GO:0045202 (synapse), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane)