wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) (P48500)
Organism: Rattus norvegicus (Rat)
Function: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
Sequence: MAPSRKFFVGGNWKMNGRKKCLGELICTLNAAKLPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHIFGESDELIGQKVNHALSEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWCKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKCNVSEGVAQCTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
InterPro domains: - IPR020861: Triosephosphate isomerase, active site (active_site) [164-174]
- IPR022896: Triosephosphate isomerase, bacterial/eukaryotic (family) [5-247]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-249]
- IPR000652: Triosephosphate isomerase (family) [3-247]
- IPR035990: Triosephosphate isomerase superfamily (homologous_superfamily) [3-247]
Interaction partners: - Glyceraldehyde-3-phosphate dehydrogenase
- Glucose-6-phosphate isomerase
- glyceraldehyde-3-phosphate dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Fructose-bisphosphate aldolase A
- Phosphoglycerate kinase 1
- Fructose-bisphosphate aldolase
- Transaldolase
- Phosphoglycerate kinase
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016860 (intramolecular oxidoreductase activity), GO:0016861 (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006081 (cellular aldehyde metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0019682 (glyceraldehyde-3-phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046184 (aldehyde biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0090407 (organophosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: NAD-specific glutamate dehydrogenase (EC 1.4.1.2) (Q5AW79)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MVSPASSLQSLPDVHVNGNEPNKLPVRSAPKLYGSNDGASSGTGTPIGFQRQPHNKILDSVAGSNVRMPSPQPTHLAIPGSPHRVLSEEDPGYIAAKFEGKEHQMEEVMDQLEKKGFIPPEFIVGETEWFYNQLGIDDTYFQTETVEAIVTQILSLYAAKVAAYARDDKKLEIRLDKEAEDHAVYIDTSKPGFSSVNGPGYEQRIDKKYIDGSTHDHSYRIETFRSPTPVPGDDGQQLRCYFVYKCQFANPNPGPQETNIDIIGEKRFLQKATPNTKAIYQEIISNAVARAGPVIEMFEIEGSREKRLVIAYRQGSAMGLFSALSDLYHYYRLTSSRKYLENFSNGITVISLYLRPLKNAEVAAKFPPIEAAVHQIIKEISLLYCIPQNRFQHHFASGRLSLQETIYAHCAWVFVQQFLNRLGSEYTSLTDLLDSNNSTHAELLAKIKKRLRTETFTSDYIAEIVNKYPDLIHKLYLDFANTHYVQTQGPTEDDFLPTLSYLRLQVDQVLDSRQLKQLVSSTAANEHDEMVMSAFRVFNASILKTNFFTPTKVALSFRLDPHFLPEHEYPQRLYGMFLVISSEFRGFHLRFRDIARGGIRIVKSRNKEAYSINARSLFDENYNLANTQQRKNKDIPEGGAKGVILLDVNHQDKARVAFEKYIDSILDLLLPPASPGIKDPIVDLYGKDEILFMGPDENTAELVDWATEHARNRGAPWWKSFFTGLSPRLGGIPHDTYGMTTLSVRQYVLGIYRKLKIDPSTIRKLQTGGPDGDLGSNEILLANEKYTAIVDGSGVIVDPQGLNREELVRLAKKRATISEFDVSKLSPNGYRVLVDESNVHLPSGELVHNGMVFRNMFHLRKELTYDTFVPCGGRPESIDLSNVGKLIENGKSTIPYIVEGANLFITQDSKLRLEKAGCILFKDASANKGGVTSSSLEVLASLSFDDQGFVQNMCVGDDDSVPEFYREYVKQVQEVIKENATLEFEAIWREHEQTGIPRSVLSDRLSVAITQLDEELQKTELWDNVELRRSVLNDALPKLLLDKIGLDTILQRVPENYLRAIFGSHLASRFVYEYGSSPSQFSFFNFMTKRLAQSKA
InterPro domains: - IPR055480: NAD-dependent glutamate dehydrogenase, N-terminal domain (domain) [98-162]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [734-1061]
- IPR056365: NAD-specific glutamate dehydrogenase, second domain (domain) [173-396]
- IPR006096: Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal (domain) [730-995]
- IPR046346: Aminoacid dehydrogenase-like, N-terminal domain superfamily (homologous_superfamily) [541-741]
- IPR016210: NAD-dependent glutamate dehydrogenase, eukaryotes (family) [54-1096]
Interaction partners: - Glutamate synthase
- Glutamine synthetase
- NADP-specific glutamate dehydrogenase
- Glutamate decarboxylase
- Glutamate decarboxylase
- Aspartate aminotransferase
- Glutamine synthetase
- Glutamate pyruvate transaminase
- aspartate transaminase
- Aspartate aminotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors), GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor), GO:0004353 (glutamate dehydrogenase [NAD(P)+] activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0009991 (response to extracellular stimulus), GO:0031667 (response to nutrient levels), GO:0015976 (carbon utilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Prolyl endopeptidase (EC 3.4.21.-) (Q9SX53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MAESRSPPVAKKVEHVMEMFGDVRVDNYYWLRDDSRTNPDMLSYLREENHYTDFVMSGTKQFENQLFAEIRGRIKEDDISAPLRKGPYYYYEKNLQGKEYIQHCRRLITDNKAEPSVYDTMPTGPDAPPEHVILDENTKAQEHDYYRIGAFKASPDHKLVAYAEDTKGDEIYTVNVIDSEALKPVGQQLKGLTSYLEWAGNDALLYITMDEILRPDKVWLHKLGTEQSSDVCLYHEKDDMFSLELHASESHKYLFVASESKTTRFVFSLDVSKTQDGLRVLTPRVDGIDSSVSHRGNHFFIQRRSTEFYNSELIACPVDDTSKTTVLLPHRESVKIQEIQLFRDHLAVFERENGLQKITVHRLPAEGQPLEGLQGGRNVSFVDPVYSVDSTESEFSSRVLRFKYCSMKTPPSVYDYDMDSGTSVVKKIDTVLGGFDASNYVTERKWVAASDGTQIPMSIVYNKKLAKLDGSDPLLLYGYGSYEISVDPYFKASRLSLLDRGFTFVIAHVRGGGEMGRQWYENGKLLKKKNTFTDFIACAERLIELKYCSKEKLCMEGRSAGGLLMGAVVNMRPDLFKVVIAGVPFVDVLTTMLDPTIPLTTSEWEEWGDPRKEEFYFYMKSYSPVDNVTAQNYPNMLVTAGLNDPRVMYSEPGKWVAKLREMKTDNNVLLFKCELGAGHFSKSGRFEKLQEDAFTFAFMMKVLDMIPASG
InterPro domains: - IPR051543: Serine Peptidase S9A Subfamily (family) [4-705]
- IPR023302: Peptidase S9A, N-terminal domain (domain) [7-427]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [26-701]
- IPR002470: Peptidase S9A, prolyl oligopeptidase (family) [473-655]
- IPR001375: Peptidase S9, prolyl oligopeptidase, catalytic domain (domain) [489-704]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008238 (exopeptidase activity), GO:0008239 (dipeptidyl-peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0030163 (protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3) (O14807)
Organism: Homo sapiens (Human)
Function: Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Sequence: MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL
InterPro domains: - IPR001806: Small GTPase (family) [9-208]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [8-191]
- IPR005225: Small GTP-binding domain (domain) [13-167]
- IPR020849: Small GTPase, Ras-type (family) [13-189]
Interaction partners: - Leucine-rich repeat protein SHOC-2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- RAF proto-oncogene serine/threonine-protein kinase
- Ral guanine nucleotide dissociation stimulator
- Rap guanine nucleotide exchange factor 5
- Rap guanine nucleotide exchange factor 2
- Son of sevenless homolog 1
- Afadin
- Ras association domain-containing protein 5
- Serine/threonine-protein kinase B-raf
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0044877 (protein-containing complex binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: CASP-like protein 2D1 (AtCASPL2D1) (Q9FFT2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cell membrane {ECO:0000269|PubMed:24920445}; Multi-pass membrane protein {ECO:0000269|PubMed:24920445}.
Sequence: MRDNNNNNTREEERSSSSKQQQPQAPMSLKIIDSCLRLSVVPLSVATIWLTVTNHESNPDYGNLEYNSIMGLKYMVGVSAISAIYALLSTVSSWVTCLVSKAWLFFIPDQVLAYVMTTSVAGATEIVYLLNKGDKIVTWSEMCSSYPHYCSKLTIALGLHVFVLFFFLFLSVISAYRAFSPFDPPCDSQTNNDA
InterPro domains: - IPR006459: Casparian strip membrane protein (family) [36-177]
- IPR006702: Casparian strip membrane protein domain (domain) [27-165]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:0099402 (plant organ development), GO:0009755 (hormone-mediated signaling pathway), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0009734 (auxin-activated signaling pathway), GO:0048364 (root development), GO:0009733 (response to auxin), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:0022622 (root system development), GO:0071365 (cellular response to auxin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: LD23683p (Q8SZS6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MIRSVLGTFQTLLKQLQPVASEEMPDISMKMYHIVCVPSCYSYFQTLLEQAGLYGLVQLHHFNWDFIYFDQGVLSLELPNLYECLYLQKNTSPLPAVAQSLRLLQMICGQPSLILSFGHHSSQLMQMAKTLGKLPAPTNPPDYGGWLVIDRDKDYPASLLTPAIYAGLLLEVFEHSSGEILVDNSKNKIRSQRVELLQGKKSKIGVNSASKPCSIRLNSTSDEIYGDNRYKRFAQVSSLIHAQVKALGLELQKLNDMQLDEMHDYVARKLPKLTELKSKVLRHLNASEIVIQMMGNFRKLQTLEEDILNNDSRKRLLSEIDELLTTDGQRFNTLRLLCLLHHCVGVAPEELQIFARNYCNLFGHQELGVFQQLSQAGLLPPLVVEKKAPTKLLSNLPLPKFQQTEFQANANRLKLLTSSGDGQDGGSSSKSQSSGLQTCPSFVFNGTYIPLVAQLCSILLKINSAEELSSKLGMIEGLHLHLDSGKITPKAYASQVKLNGVADQDMFPLRLRNLFVFIVGGASYAEIAACDFVAKLTGAQITVASDSLMAGSDLIATAFNR
InterPro domains: - IPR043155: Vacuolar protein sorting-associated protein 33, domain 3b (homologous_superfamily) [296-384]
- IPR001619: Sec1-like protein (family) [27-555]
- IPR036045: Sec1-like superfamily (homologous_superfamily) [2-555]
- IPR043154: Sec1-like, domain 1 (homologous_superfamily) [1-64]
- IPR043127: Sec1-like, domain 3a (homologous_superfamily) [169-294]
- IPR027482: Sec1-like, domain 2 (homologous_superfamily) [66-561]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0000149 (SNARE binding), GO:0019905 (syntaxin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0098542 (defense response to other organism), GO:0071417 (cellular response to organonitrogen compound), GO:0071219 (cellular response to molecule of bacterial origin), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0042742 (defense response to bacterium), GO:0032494 (response to peptidoglycan), GO:1901699 (cellular response to nitrogen compound), GO:0002237 (response to molecule of bacterial origin), GO:1901701 (cellular response to oxygen-containing compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0099023 (vesicle tethering complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0030897 (HOPS complex)
Protein: Protein YIM1 (P28625)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not known
Subcellular location: Lipid droplet. Mitochondrion.
Sequence: MSDEIVTNKSVTYVNNTTPVTITSSELDLRSCYQDDEVVIEVHAAALNPIDFITHQLCNSYIFGKYPKTYSRDYSGVIIKAGKDVDNRWKVGDKVNGMYSHIYGERGTLTHYLILNPAKDVPITHMVEVPKDENDPYDDFVYAAAWPLTFGTAFSTLYDFKKDWTSDSKVLVIGASTSVSYAFVHIAKNYFNIGTVVGICSKNSIERNKKLGYDYLVPYDEGSIVENVKKLKQSVLENDKFDMIFDSVGNHDFFPVIDQFLKPKAKNSFYVTIAGNNKADYKNISWRDFVSLSSILKAINPFKKYNWRFGHPYPPNNFIEVGNEMIKKGTYKPPIDSVYEFDQYKEAIDRLMSNRAKGKVVVKMK
InterPro domains: - IPR011032: GroES-like superfamily (homologous_superfamily) [26-172]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [139-279]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [35-115]
- IPR050700: YIM1 and Zinc-containing Alcohol Dehydrogenase Families (family) [35-364]
Interaction partners: - Sterol esterase TGL1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0090150 (establishment of protein localization to membrane), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0006612 (protein targeting to membrane), GO:0006605 (protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0098857 (membrane microdomain), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005770 (late endosome), GO:0097708 (intracellular vesicle)
Protein: Ig lambda chain V-1 region (P04210)
Organism: Gallus gallus (Chicken)
Function: Not known
Sequence: MAWAPLLLAVLAHTSGSLVQAALTQPSSVSANPGETVKITCSGDRSYYGWYQQKAPGSAPVTLIYDNTNRPSNIPSRFSGSKSGSTATLTITGVQADDEAVYYCGSADSSSTA
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [24-107]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [22-110]
- IPR007110: Immunoglobulin-like domain (domain) [5-113]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [22-113]
- IPR003599: Immunoglobulin domain subtype (domain) [26-112]
- IPR050150: Immunoglobulin Variable Light Chain (family) [20-105]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Probable serine/threonine-protein kinase drkA (EC 2.7.11.1) (Receptor-like kinase 1) (Receptor-like kinase A) (Vesicle-associated receptor tyrosine kinase-like protein 1) (Q54H46)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MKKLPFLIIIIYIFLILISISSSIDYNYNNDIDNNNNNIINRNKNKNKNNLYNNKVIIKNDDNDDEINNKFKIRLDDNEDQDIYNEYHFLSKVHNRLAFNIFGSSSENSGSGSNSNSNSKNTDSSTGPTPSPISINGTLNSTATVYWSGGKSSCKSVNCTEEGFSTGDSYACSYEITPTYQRGQWEKGVKYFKDPLPKSILTSQVVGVSFVINGVVGCTPLKQELTTIEFLIQDVQVGQTISTNRSDDCSCGICYKDYEILPQSYDLLGYNKSGLNKVQLLLLDNSICATSLDIIFYYHPSTIPPTPTPTPSKPTISLLKKYLIIGFSIVGGLLIIGGCFLLIRNRYRSSGYYKPDKNDYTQIKDGKDIDIHQIKIGVRIGKGNYGEVYLGTWRGSQVAVKKLPAHNINENILKEFHREINLMKNLRHPNVIQFLGSCLIPPDICICTEYMPRGSLYSILHDQALQLQWSLLIKMMIDAAKGVIYLHNSTPVILHRDLKSHNLLVDENWKVKVADFGLSTIEQQGATMTACGTPCWTSPEVLRSQRYTEKADVYSFGIILWECATRQDPYFGIPPFQVIFAVGREGMRPPVPQNGPPKYIQLLIDCLNENPSHRPTMEQCLERLESIDSSGYSDLQYVRQQL
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [361-624]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [493-505]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [375-624]
- IPR017441: Protein kinase, ATP binding site (binding_site) [380-402]
- IPR000719: Protein kinase domain (domain) [374-633]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [125-629]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0099120 (socially cooperative development), GO:0048856 (anatomical structure development), GO:0030587 (sorocarp development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Small GTP-binding protein RAB6, putative (Q586J5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: METNSAPVASTKKGGDGVTAETAPVVKHKIVLLGDQAVGKTSLITRFMYDTFDQQYQATIGIDFFSKTLHINNRATRLHVWDTAGQERFRSLIPSYIRNSAATVVVYDITSRSSFLSTFKWIDEVRAARGDDVIIALVGNKCDVQEKREVSADEAQKRADENRLIFVEVSAKTGTNVKSLFRKVAEAIPVVEICEKGTVPLGKRRDPFLLTPSQQQKDGEGAGWREGGCC
InterPro domains: - IPR001806: Small GTPase (family) [21-230]
- IPR050227: Ras-related protein Rab (family) [29-196]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [24-197]
- IPR005225: Small GTP-binding domain (domain) [28-184]
Interaction partners: - Vacuolar protein sorting 33, putative
- Rab GDP dissociation inhibitor
- Ribosome control protein 1 domain-containing protein
- ADP-ribosylation factor-like protein, putative
- Vps53 N-terminal domain-containing protein
- Conserved oligomeric Golgi complex subunit 6
- Conserved oligomeric Golgi complex subunit 8
- Uncharacterized protein
- RanBD1 domain-containing protein
- Ran-binding protein 1, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0006897 (endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)