Protein: GTP 3',8-cyclase (P30745)
Organism: Escherichia coli (strain K12)
Function: Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z)
Sequence: MASQLTDAFARKFYYLRLSITDVCNFRCTYCLPDGYKPSGVTNKGFLTVDEIRRVTRAFARLGTEKVRLTGGEPSLRRDFTDIIAAVRENDAIRQIAVTTNGYRLERDVASWRDAGLTGINVSVDSLDARQFHAITGQDKFNQVMAGIDAAFEAGFEKVKVNTVLMRDVNHHQLDTFLNWIQHRPIQLRFIELMETGEGSELFRKHHISGQVLRDELLRRGWIHQLRQRSDGPAQVFCHPDYAGEIGLIMPYEKDFCATCNRLRVSSIGKLHLCLFGEGGVNLRDLLEDDTQQQALEARISAALREKKQTHFLHQNNTGITQNLSYIGG
InterPro domains: - IPR050105: Molybdenum cofactor biosynthesis MoaA/MoaC (family) [3-329]
- IPR040064: Molybdenum cofactor biosynthesis protein A-like (family) [2-329]
- IPR058240: Radical SAM superfamily (homologous_superfamily) [5-290]
- IPR010505: Molybdenum cofactor biosynthesis protein A-like, twitch domain (domain) [186-321]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-329]
- IPR000385: MoaA/NifB/PqqE, iron-sulphur binding, conserved site (conserved_site) [20-31]
- IPR013483: Molybdenum cofactor biosynthesis protein A (family) [5-329]
- IPR007197: Radical SAM (domain) [2-329]
- IPR006638: Elp3/MiaA/NifB-like, radical SAM core domain (domain) [14-222]
Interaction partners: - Cyclic pyranopterin monophosphate synthase
- Cyclic pyranopterin monophosphate synthase
- Cyclic pyranopterin monophosphate synthase
- Cyclic pyranopterin monophosphate synthase
- Molybdopterin synthase catalytic subunit
- Molybdenum cofactor biosynthesis protein B
- Molybdenum cofactor biosynthesis protein B
- Molybdopterin synthase sulfur carrier subunit
- Molybdopterin molybdenumtransferase
- Molybdopterin adenylyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0051540 (metal cluster binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0051536 (iron-sulfur cluster binding), GO:0051539 (4 iron, 4 sulfur cluster binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0051189 (prosthetic group metabolic process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0043545 (molybdopterin cofactor metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019720 (Mo-molybdopterin cofactor metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0032324 (molybdopterin cofactor biosynthetic process), GO:0006777 (Mo-molybdopterin cofactor biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)