Protein: Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (Q9D1L0)
Organism: Mus musculus (Mouse)
Function: Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y6H1}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y6H1}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Y6H1}. Note=Mainly localized in the intermembrane space. {ECO:0000250|UniProtKB:Q9Y6H1}.
Sequence: MPRGSRSRTSRVTPPASRAPQMRAAPRRAPAAQPPAAAAPSAVGSPAAAPRQPGLMAQMATTAAGVAVGSAVGHTLGHAITGGFSGGGSAEPAKPDITYQEPQGAQLQNQQSFGPCSLEIKQFLECAQNQSDVKLCEGFNEVLRQCRIANGLM
InterPro domains: - IPR010625: CHCH (domain) [116-147]
- IPR055304: Coiled-coil-helix-coiled-coil-helix domain-containing protein 2/10-like (family) [1-151]
Interaction partners: - Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
- ATP synthase peripheral stalk subunit d, mitochondrial
- Cytochrome c oxidase subunit 8A, mitochondrial
- Cytochrome c oxidase subunit 6A1, mitochondrial
- ATP synthase peripheral stalk subunit F6, mitochondrial
- Parkinson disease protein 7 homolog
- MICOS complex subunit Mic25
- Vacuolar protein sorting-associated protein 35
- F-box only protein 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051651 (maintenance of location in cell), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0051235 (maintenance of location), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0032507 (maintenance of protein location in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0042391 (regulation of membrane potential), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045185 (maintenance of protein location), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043954 (cellular component maintenance), GO:0072595 (maintenance of protein localization in organelle), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0006996 (organelle organization), GO:0034330 (cell junction organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0051457 (maintenance of protein location in nucleus), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0034331 (cell junction maintenance), GO:0062125 (regulation of mitochondrial gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0050808 (synapse organization), GO:0034504 (protein localization to nucleus), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0099558 (maintenance of synapse structure)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)