Protein: Carboxylic ester hydrolase (EC 3.1.1.-) (A0A8J8XQI9)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: LQTQHTMVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEKLVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
InterPro domains: - IPR002018: Carboxylesterase, type B (domain) [32-551]
- IPR019819: Carboxylesterase type B, conserved site (conserved_site) [119-129]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [28-558]
- IPR050654: Acetylcholinesterase-related enzymes (family) [13-600]
- IPR019826: Carboxylesterase type B, active site (active_site) [214-229]
- IPR000997: Cholinesterase (family) [99-479]
- IPR014788: Acetylcholinesterase, tetramerisation domain (domain) [566-600]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0050997 (quaternary ammonium group binding), GO:0043167 (ion binding), GO:0016787 (hydrolase activity), GO:0043169 (cation binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0007610 (behavior), GO:0009991 (response to extracellular stimulus), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0007611 (learning or memory), GO:0050805 (negative regulation of synaptic transmission), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:1901700 (response to oxygen-containing compound), GO:0050877 (nervous system process), GO:0099177 (regulation of trans-synaptic signaling), GO:0097164 (ammonium ion metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0022008 (neurogenesis), GO:0050890 (cognition), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0014016 (neuroblast differentiation), GO:0031667 (response to nutrient levels), GO:0033993 (response to lipid), GO:0050804 (modulation of chemical synaptic transmission), GO:0048545 (response to steroid hormone), GO:0007612 (learning), GO:0014070 (response to organic cyclic compound), GO:0019695 (choline metabolic process), GO:0033273 (response to vitamin), GO:0051593 (response to folic acid), GO:0043279 (response to alkaloid), GO:0048699 (generation of neurons), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen)