Protein: Helicase SWR1 (Q59U81)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling
Subcellular location: Nucleus
Sequence: MPENGRLRRTSARLTQNGTSTSSSTIYQNGKRTSQHAQETSTASNKKRKVSTQSKEDKLSDIIVDFNLAVNELYQLKEYKSIISWDPIENSSANDRGIKAEFEEFVKNNDYRLVWDKEIENNSNIDSLPLRFQKKKLAEQNKLLDDKFSIRQNVLASSKMLEESLVNKTRDEVKIESTFKAIQSQEKAGSKLKTPSQTSNAKTNIRKSGSTTPKRGNENGSRKQALEDQDEIIELSDDSSVVEIESDLSDAETHYRIKCIKKTVPPPLVTHPSHIPQWRPENLEDGNRSTGRLIQLKDSSSSSKIINFDPTPLEIIQLKDEVIAAPKLTEKLQNFLNNDFKTPIIDESNVPDYNFTRDEYNTIMSQQEKLLRKLYHKVNIENSLELNGDKIERRKVILPQSNIKLTDPFRNTFSVKPKLHGAANNATHQDYLLAQGMAFSKVHQQMRKQHHLRTRKIAAMIDQHFKKKKGEKERLAKEREQNLKKMSRLTMQAVKKRWNQAQKVYQIIQNEKEEELKKIKGRQHLSEMLEHSTQLLEAQLTSSREPTVEAESDDNSTTFDDNTNDSDNFSSSEEEENEEDNTQQQINGNKKYDVNGKSNDENDMSLSVEELRKKYADLETSVEPLSSNVTSDKERESETSSEDAESSDDDDTDVTRGLASLYQNDEVADFATTTFEYSAEEKKLIEDLNQESDSRMNSLLDSDSVSSISDSESSEESSSDTEMDQSNVSEPPRSSETGSNTGLASLFTNGTIVSDEEDDASISSNFENESDESMNSSDRELEVNGNGKIDKIASTDEDDSNVEIVNGSKVKDVPIPSLLRGTLRPYQKQGLNWLASLYNNNTNGILADEMGLGKTIQTISLLAYLACEHHKWGPHLIIVPTSVMLNWEMEFKKFAPGFKVLTYYGSPQQRAQKRKGWNKPDAFHVCITSYQLVVQDQQSFKRRRWTYMILDEAHNIKNFRSTRWRALLNFNTENRLLLTGTPLQNNLMELWSLLYFLMPSSKVNQAMPEGFANLDDFQQWFGKPVDRILEQTSAGNSDLIDENERTTQKMDEETRNTVARLHQVLRPYLLRRLKKDVEKQMPGKYEHIVYCRLSKRQRFLYDDFMSRAKTKETLASGNFLSIINCLMQLRKVCNHPDLFEVRPIVTSFAMPRSIPSYYQSTNELVKRQFNKDEKVSFQALNLDVTGCENMNYFVCQSTGKLMTTEPFQDQINKLKILLVEFENSDPINYVSYYQRLRREEQAEIKEKLEHVVYLNNLRCGRKPIYGESLLRLLTVNAHDFSDEPYNKYCLTLSGRVDKMNDTIEKYSIITPAAVALDMKDQLIPISTKQRILHEVAENKIDNPFHKAQVKLSIAFPDKTLLQYDCGKLQKLATLLQELTSQGHRALIFTQMTKVLDILEQFLNIHGYRYMRLDGATKIEDRQLLTEKFNRDPKIPVFILSTRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQVRDVHIYRFVSEYTIESNIIKKANQKRQLDNVVIQEGEFTTDYFGKFSVRDLVSDSNIGKEITDRTIDFSGDAKMGNVLAQAEDEEDRVAAGAALKEVAIDDDDFKEETRSATTGATPAPTETNALSTTDGDAAFIDVDYEDGIGHIDEYMLRFISDGYYL
InterPro domains: - IPR014012: Helicase/SANT-associated domain (domain) [416-488]
- IPR038718: SNF2-like, N-terminal domain superfamily (homologous_superfamily) [794-1095]
- IPR001650: Helicase, C-terminal domain-like (domain) [1367-1520]
- IPR050520: INO80/SWR1 chromatin remodeling helicase (family) [30-1637]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [819-1020]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [803-1577]
- IPR000330: SNF2, N-terminal (domain) [826-1138]
- IPR049730: SNF2/RAD5-like, C-terminal helicase domain (domain) [1355-1490]
Interaction partners: - RuvB-like helicase 2
- Histone H2A.Z
- RuvB-like helicase 1
- HIT-type domain-containing protein
- Actin-like protein ARP6
- Actin-related protein 4
- SWR1-complex protein 4
- Protein AF-9 homolog
- Vps72/YL1 C-terminal domain-containing protein
- Actin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0140097 (catalytic activity, acting on DNA)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0030447 (filamentous growth)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0070603 (SWI/SNF superfamily-type complex), GO:0000118 (histone deacetylase complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097346 (INO80-type complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0000812 (Swr1 complex), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome)