Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q4GZ26)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MPRYTAMRRLGPVGHSGGISSNGVTTVGAVTASNVGNGVVNIGGDGSQGVAMGPGATDVASARPLLIVPNTTSAAGGSADVSDEEVDQLLRELERSVDSPQAAAVMRDAVWAIERRAFSSCDPHSRDYFLESRVRIILMSLSTTSDVKQLLLAVDFIEALLAVPYTNLQHRFTRLCRSLMNILRCGIEEPAREAQRVLKRMLVTDSQFGAYHTPLRSFITKELRDNCKVALMRLYGRAQQANVSFTPDFLSTMLAAEATAEISPRFITGTLRQQVLELASMLAGFSDLLLRRAAYRCMVVLFKNTSAMRRKEVVLENRRIINEAIRSLNLSHNSESSIISTLETLRALLSSRGVHCMDKQVNTLPQLCVLVTEQHRISKTTAVRNAVCDLVPVIAETDISSAARRTTYCAIIMEPVKNVRDDSNKDLELRNLAIFIQNVGYEVLDSTNRVNLDSIIQRYITRRGTEEECWHILAAICSSRARPETQRTHMCSKTSYIAMSSSSAMQKGCETIQGHQSGGEISLSAQELRSASAEAHSVCQLVAGESQNSCNSHELMQPVEALVRRCLPHMVHAVLSDEFVRYITIIQDHLPSLSSDLQTYLDQLVNRTLRNDKRKYCGGEVEDGALVAQVFAGDRLSTELGNSQPQEDIIQSSTLAYVTAMGRLAQYLLPTTLPEGGAINWQQSQGATSTTATDGNGQGYSLGSVETFCKSVVAGQPQLVSPESTLSSAAGATTAEVCSGAAPDSVGASELKIALEVFSKRQITSSDQLREVSDIIIQYQRHPDKRVRQQCCTTVIEALKCWARYSQSDRTSAYSSLVPDLLEVYLKNVAMELDPKVRLVEVTLLADAVELRMFLREKRIIDTLISFLHDISHVREKTMELLVTLAQDNHTGPSVETVQYSLLIVVESSVAALEYSSDPRILIRHMSDLQTVAKFSLRPLMGHLDRTFVACRRRLVEEVVPDTIALSTLKTLRTILEAIKREEAVLLKYKDVALELYAPVAVALRASTASPLSHAAIGVLVCMHEIGASPLNWDARQLHELLQSVTAVYIEAANSTEEELGRALTLFGQIGAVDPATKPDTAAMKKKDDEAAIQDEADLELTYDYTKIVYRNLSRMLDLSLSESVCVQSMCTLLHLVRLTTDRKELIGGMHAIKAILQIARRANDAPLLRIEALHILAAITSLRHEKVCKTLLPELVTLFEQLWYPQDHALFRAVLNLVSALKPGNLTGKEQSEVWPWLYPRLVDVALQDHTETREFCLRVVGIIQHAKYIPPHCIPIVFPMLTQFVQQMDQLAELRSLSLCAAIRIVCNLQAVQHLPSLMHTICTLTRHCDLTENLGPRLSTPTLHRSLRLLSNTHPNGEADVNALCERLCATGSEGSADAGGCFTNEGGETLPTSTQPNSSFHCGNGDYASAPYLGQYTQKCQQQQQGGTYLDPNDDEAYDTLPQGQQDITAFMKHVEFGLRAKDNKWREWFAEFQKNMIVASPHPVFRIMVDLFDKHEPLRRKLFHPSFKCFYESLNAEHMKKVKDVLNLALRSSDTEVVSKCIGLADYLDHNPPNISESVLQQLRHLEGNEPMDVGKFTKHSNLHVGNVIAGSRSPTPACRHEPGGYYASHHGQLYRNISDNYNFESVLHSLNSPKTEGPVFNEGVRPPSHKVQDVGNGEHEVTDNGGTDSGCGVERNGKEGRSESESGDVNGSARRQTMLPVAKSIEGDTNEGLSFLAGPVARRITVSAHHTTNVNASDGTCPNTGDAEVHIRATAIPSTVNPLFTNDSLVEAALRTRMPDKAMSYLENKLLPVMQKYRYAHSVPKEAVQAVVLPLASLYSRLEMQDSVVGLFHAMRYKSDNEDGFAYELLQWWDVAQGVYATKVHDCCGSSARDIDGYVRMLCLCGEWERALQVVKDTYKSLDQPSSTIAQSGAMAAWILGKWDDVKMLIERLPNKEKGNITLRHFFQNATLFHQEFGCRAQWDCGVQDGQRRLETSPQVEALRASIMRAKMEVDESLKTLLPLSYAHAYENLTMLQHFTEMEEHIAYMESRTEEFRGQLRERWNRRFAALKPDSLMPNLRSLMLHSLVLNASEMSVMVVNFCERTGTNYPQLSKWAMEWLKQGKFPRANHLSQSCHVLPATPVSLEPCVAITYIGQVWSGGQRQKAVQLMENFLEETHSTLEEQQPAAYGVAQLRLGMWKQEMFADSFWKVEHRQEVLRHFHEAVRAVPGSCEAWHSWGLMNYRVQQRDCSLSRYEQRLFVEAAHQGFVAAICRSASPSTALPGVMRLLQLWVFHNGMSLLKESVADSVARIPTDYWVQAIPQLIGHLRSASHDVRDVVSMILQRLCVAHSQAVVFPLLVVLMSADGGGGETHSRRKELARSIINNLPKRIRAEAELVATLLINASATPIERIGESLSAVATAWNPNAEYEEDKEEVRRKLRYVLDVFNTNRRQLLYNVGDIGQYVRIVMEEDACGRREKASGILTQLVEEITKHISEKLGKEPQKAMEPLLNLRNLSIAVFGEYDIQYTNFPTIASFSSKLDVIPSKKRPRRIRLSGSNGCMYTYCLKGNEDIRMDERVMQLFGMVNVLLSDAKTAKSAFIHRFPVIPISDNVGLLGWVEHANTINNTICTHRNTISKVRTHHESNTLRAYVETIGSWEKLSMIRRTEILDYVMSQKDCEAVDVARAMWHRSNTAEQWLERRTAFTQSLATMSMVGYVLGLGDRHLGNILLSMSTGKIVHIDFGDSFDVGRLRHVLPETVPFRLTRMLTNAMEVFGVDGVFRASCNRTQSTLHKNADSIMALLTAFVHDPIVQHKGKMRNMMEKSRTPQNIVERIRNKLRGTEMAVRNADTVIFNTVLESSRRPDLLYMSHAFNDVAKRTVVNGRTTEEQVSMLIDEATRLENYAALYFGWGPLW
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [78-2581]
- IPR014009: PIK-related kinase, FAT domain (domain) [1774-2351]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [2484-2829]
- IPR003152: FATC domain (domain) [2871-2903]
- IPR003151: PIK-related kinase, FAT (domain) [1919-2277]
- IPR050517: DNA Damage Response and Repair Kinase (family) [115-2903]
- IPR018936: Phosphatidylinositol 3-/4-kinase, conserved site (conserved_site) [2696-2716]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [2661-2850]
- IPR026683: Serine/threonine-protein kinase TOR, catalytic domain (domain) [2522-2803]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [2525-2867]
Interaction partners: - Rapamycin-insensitive companion of TOR2
- Uncharacterized protein
- 1-phosphatidylinositol-3-phosphate 5-kinase
- Phosphoinositide phospholipase C
- 1-phosphatidylinositol 4-kinase
- phosphatidylinositol 3-kinase
- 1-phosphatidylinositol 4-kinase
- Protein artemis
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- Ras-family member, GTP-binding protein, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0007059 (chromosome segregation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)