wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Collagen alpha-1(XXII) chain precursor (Collagen type XXII alpha 1 chain) (M5BFV8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
Sequence: MEFRFGLRISLVLTVLALTLYGGGVEGQRAGCKNVHYDLVFILDTSSSVGKENFEKIRQWVANLVESFDVGVDKTRVAVVRYSDRPTVEFNLARYKTLEEVKRAAGNIRYLGGNTKTGDAISFTTTNIFTERAGARPAAKGIQKVAILLTDGQSQDFVLEPSVAAAAAGIRLFAVGIGEALKEELEEIAAEPKSAHVFHVTDFDAIDKIRGRLRRRLCENVLCPNMKVQAGRFRPNSTSAGLTEVPGFDLMEFFNVRDFLGEKFEPGQTPYVRLGALPIVQKTEDVLPQGLPDEYAFVTTFKFRKTSRKEDWYLWQVYDKYGIPQVSIRLDGENRAVEYNAVGLTKDAVRAVFRNPEVDNLFDRNWHKIGMRVDSKSVSLFLDCKHIETLPIEEREDIDIQGKTVIGKRLYDSVPIDFDLQRMVIYCDGKQSEQETCCDIPGGLCEQTLVTEAPPVPLPTPKPTSAEQKKPAAANCSCPAGERGDTGLPGAPGPKGEKGDPGLKGAEGPPGLKGLKGERGQAVSIKGDRGEKGDSGEFGEPGLTGDRGEKGSDGLPGLAGKKGDKGERGDQGVAGEAGLPGPLGPKGIQGNAGPPGAPGAQGLSGGAGNKGEKGSTGDRGERGADGFPGKPGLPGKEGVRGLIGAPGPNGVKGEKGAQGPAGIPGDAVQLAGLKGETGAQGEAGLPGVDGLPGPPGPPGPPGLPGETGDTGPRGKKGDAGLPGVDGLPGPPGPQGPPGVSGSPGQTGPPGLPGEIGFSGKPGESGKPGSPGKDGADGFPGNDGEKGQKGESGQDGFPGKPGPKGDEGPPGPRGPPGERGESGLTGQVGPMGPKGERGNHGERGREGPSGAKGEKGDKGEIGPRGPAGAPGNVANVIPEPGEPGKPGEKGEKGDQGKPGDMGQRGLPGEQGFRGQPGPVGPKGDAGDKGEPGRHGDPGPPGLMGPQGSRGLPGNVGIPGSIGPPGIAGQKGDKGDGGKDGPPGPPGPTGEPGLRGEIGLPGKGKEGEKGDAGPPGIAGPPGLRGLPGNQGMQGMPGNRGPPGEGSPGSQGPPGPAGPPGAAGLRGPPGVAGVQGPAGHNGIPGRPGEKGSPGEPGKAADLSDLNLKGVCSDCPAGPPGQPGIPGPPGDKGHSGPPGKNGQDGYAGAPGPTGPAGPPGSDGAKGVKGDRGPAGTPGDKGEKGAPGPPGYPGAAGAMGQPGNDGNPGPVGTPGPPGEKGKEGMTGIQGPPGLPGLMGMMGKPGKDGRPGESGEPGKQGEPGQPGRDGLRGMPGFKGHRGEPGPPGSKGEEGKQGVPGREGQPGKDGNSGPPGPEGMRGPRGESGQPGEQGPTGKPGSQGNPGQPGHKGEAGSPGLPGFPGPKGPSGPPGPIGPEGKQGMLGKAGDRGQKGEKGDNGIKGDKGPVGDPGIPGNPGSPGRKGHTGMMGMSGPPGEVGPAGPPGTPGIPGLPGLRGETPSLEQMRRLIQDELSKQLDAKLAYLMAQMQPAHIKSTAGRPGPPGPPGKDGSPGRQGPTGEPGMPGQNGVEGLRGPAGPKGERGSKGEKGEDGVGQRGEPGPIGPMGPAGMPGDGKDGLPGAAGAQGEPGNPGPHGQPGPPGPTGQCDPSQCAYYASLASRPHTKNVKGT
InterPro domains: - IPR002035: von Willebrand factor, type A (domain) [36-218]
- IPR008160: Collagen triple helix repeat (repeat) [480-1545]
- IPR050149: Collagen superfamily (family) [1219-1598]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [246-438]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [28-228]
- IPR048287: Thrombospondin-like, N-terminal domain (domain) [241-429]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0048762 (mesenchymal cell differentiation), GO:0060485 (mesenchyme development), GO:0001837 (epithelial to mesenchymal transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Putative S-adenosyl-L-methionine-dependent methyltransferase Rv0281 (EC 2.1.1.-) (P9WFI9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Sequence: MRTEGDSWDITTSVGSTALFVATARALEAQKSDPLVVDPYAEAFCRAVGGSWADVLDGKLPDHKLKSTDFGEHFVNFQGARTKYFDEYFRRAAAAGARQVVILAAGLDSRAYRLPWPDGTTVFELDRPQVLDFKREVLASHGAQPRALRREIAVDLRDDWPQALRDSGFDAAAPSAWIAEGLLIYLPATAQERLFTGIDALAGRRSHVAVEDGAPMGPDEYAAKVEEERAAIAEGAEEHPFFQLVYNERCAPAAEWFGERGWTAVATLLNDYLEAVGRPVPGPESEAGPMFARNTLVSAARV
InterPro domains: - IPR011610: S-adenosyl-L-methionine-dependent methyltransferase ML2640-like (family) [16-279]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [1-302]
- IPR007213: Methyltransferase Ppm1/Ppm2/Tcmp (family) [18-198]
Interaction partners: - ESX-3 secretion system protein EccC3
- ESX-3 secretion system protein EccA3
- ESX-3 secretion system ATPase EccB3
- Uncharacterized PPE family protein PPE3
- S-adenosyl-L-methionine-dependent methyltransferase
- ESAT-6-like protein EsxG
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0052553 (modulation by symbiont of host immune response), GO:0052559 (induction by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Telomere replication protein EST3 (Q5A7P3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).
Subcellular location: Nucleus {ECO:0000305}. Chromosome, telomere {ECO:0000305}.
Sequence: MFRSVSLSSLIPFLIIVSIAMQRPENDVPMIMQSSWLVNEVIKSINSNGQYINALIKKDFQPTVLPVSFILRILKFTATTDSKDITAVLADSTHKIFAIFLFFPAIVDFENKYHHRMTYNTRSCLIRIHKANLKFMDKSTVKKCYGRKSDGGLAIAVLEVLEFDIFFKDQYSFINSIENRLKYVYDDVEYNQLCGKKKHKPEYEDLMCDI
InterPro domains: - IPR019437: Shelterin complex subunit TPP1/Est3 (domain) [34-182]
Interaction partners: - Telomerase reverse transcriptase
- Est1p
- Cdc13p
- ATP-dependent DNA helicase II subunit 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0008047 (enzyme activator activity), GO:0003677 (DNA binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0043565 (sequence-specific DNA binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0042162 (telomeric DNA binding), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0051276 (chromosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0043229 (intracellular organelle), GO:0000781 (chromosome, telomeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: UBX domain-containing protein (Q580U3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MAMCDCSETVAISLLSEANFDVDYAYHLHMSRTQGADESVTSLHGTSPQGEAPHLQEPELPHASYVVNRLDGGGGYVGGNYPHERDFLLDEVESEQDLLDSVFPIPAFVHRSPEPFDTFCTDSLNRDQWVILSFVLNDFTGFCVNRDIWRSEDLLEVLSMFSIYQTTADVGEGPGLAHGYRLDVEKDIPTLLIINPITRVKETRIPINVHEATIESYEVKNALLTFVGEKGSPNQWEECRLRGTYENASPVLHTENSREYVDVEETSIPFSEPEAGRRDEANEGVVAQPPQILAVDISPYEVPAEVGSAFTLRCRLPKEQLTLRLKPEMPVLLLLKYLSTRLYFSQSTAFPGGVPNCSLRVGFPPKDLIVEDGEVQLGTCPGLRSGDTVVLHIH
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [90-236]
Interaction partners: - Ubiquitin fusion degradation protein, putative
- MPN domain-containing protein
- Proteasome subunit beta
- Katanin p60 ATPase-containing subunit A-like 2
- Elongin-C
- UBX domain-containing protein
- ATPase, putative
- Cell division cycle protein, putative
- ATPase, putative
- Valosin-containing protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23) (Q9C075)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MNSGHSFSQTPSASFHGAGGGWGRPRSFPRAPTVHGGAGGARISLSFTTRSCPPPGGSWGSGRSSPLLGGNGKATMQNLNDRLASYLEKVRALEEANMKLESRILKWHQQRDPGSKKDYSQYEENITHLQEQIVDGKMTNAQIILLIDNARMAVDDFNLKYENEHSFKKDLEIEVEGLRRTLDNLTIVTTDLEQEVEGMRKELILMKKHHEQEMEKHHVPSDFNVNVKVDTGPREDLIKVLEDMRQEYELIIKKKHRDLDTWYKEQSAAMSQEAASPATVQSRQGDIHELKRTFQALEIDLQTQYSTKSALENMLSETQSRYSCKLQDMQEIISHYEEELTQLRHELERQNNEYQVLLGIKTHLEKEITTYRRLLEGESEGTREESKSSMKVSATPKIKAITQETINGRLVLCQVNEIQKHA
InterPro domains: - IPR018039: Intermediate filament protein, conserved site (conserved_site) [368-376]
- IPR002957: Keratin, type I (family) [34-408]
- IPR039008: Intermediate filament, rod domain (domain) [71-382]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0061303 (cornea development in camera-type eye), GO:0048513 (animal organ development), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: CCT motif family protein (Q8LDM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00357}.
Sequence: MDTQRLPKKEEEEEEDHLLSSTFESINGHSRDQHNHSIDDFESIFDITIDNLSCSNELTWDFWEEDEDEDVGEEEKRSSTDQEGSSFGFWENKPTDYEDKDLGLKLNLNHQEVIDAWSDHQKPLWTDTSTLDNSVYRGEVPVIEEKRNMRREASVLRYKEKRQSRLFSKKIRYQVRKLNADKRPRFKGRFVKRET
InterPro domains: - IPR010402: CCT domain (domain) [151-193]
- IPR052453: CONSTANS-like zinc finger regulators (family) [8-194]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045184 (establishment of protein localization), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0071702 (organic substance transport), GO:0051252 (regulation of RNA metabolic process), GO:0008104 (protein localization), GO:0010468 (regulation of gene expression), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0072596 (establishment of protein localization to chloroplast), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0072598 (protein localization to chloroplast), GO:0045036 (protein targeting to chloroplast), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Hemiasterlin resistant protein 1 (Q09254)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MVRRRTASPSPSAPVRSAPRPAAQSSFAAPPPRPAAAAPAYHPPAAPTPMGAPMGAPSQGPGLMKQMAATAGGVAIGSAVGHAVGGMFTGGGSSHAEQAPAAAAAPAGAPQASGYSQPCEFEWRQFVDCAQNQSDVSLCNGFNDIFKQCKARYA
InterPro domains: - IPR010625: CHCH (domain) [119-151]
- IPR055304: Coiled-coil-helix-coiled-coil-helix domain-containing protein 2/10-like (family) [12-152]
Interaction partners: - RING-type domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0031323 (regulation of cellular metabolic process), GO:0006979 (response to oxidative stress), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0034599 (cellular response to oxidative stress), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0062197 (cellular response to chemical stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 2-carboxy-1,4-naphthoquinone phytyltransferase, chloroplastic (EC 2.5.1.130) (1,4-dihydroxy-2-naphthoate phytyltransferase) (1,4-dihydroxy-2-naphthoate polyprenyltransferase) (Protein ABERRANT CHLOROPLAST DEVELOPMENT 4) (menA-like protein) (AtMENA) (Q0WUA3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4-naphthoquinone.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:15686525}; Multi-pass membrane protein {ECO:0000269|PubMed:15686525}.
Sequence: MVNFVSLCDIKYGFVPKNSTDLFVKRKIHKLPSRGDVITRLPVFGSNARENLNAKPRRNLRVRPIFCKSYGDAAKVYQEEEIPRAKLIWRAIKLPMYSVALVPLTVGASAAYLETGLFLARRYVTLLLSSILIITWLNLSNDVYDFDTGADKNKMESVVNLVGSRTGTLAAAITSLALGVSGLVWTSLNASNIRAILLLASAILCGYVYQCPPFRLSYQGLGEPLCFAAFGPFATTAFYLLLGSSSEMRHLPLSGRVLSSSVLVGFTTSLILFCSHFHQVDGDLAVGKYSPLVRLGTEKGAFVVRWTIRLLYSMLLVLGLTRILPLPCTLMCFLTLPVGNLVSSYVEKHHKDNGKIFMAKYYCVRLHALLGAALSLGLVIAR
InterPro domains: - IPR026046: UbiA prenyltransferase domain containing protein 1 (family) [60-382]
- IPR000537: UbiA prenyltransferase (family) [101-357]
- IPR011937: 2-carboxy-1,4-naphthoquinone phytyltransferase (family) [74-379]
Interaction partners: - Alternative NAD
- Geranylgeranyl diphosphate reductase, chloroplastic
- 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Solanesyl diphosphate synthase 2, chloroplastic
- Solanesyl diphosphate synthase 1, chloroplastic
- 1,4-dihydroxy-2-naphthoyl-CoA thioesterase 1
- 2-succinylbenzoate--CoA ligase, chloroplastic/peroxisomal
- Protein PHYLLO
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:1901661 (quinone metabolic process), GO:0042181 (ketone biosynthetic process), GO:0006743 (ubiquinone metabolic process), GO:1901663 (quinone biosynthetic process), GO:0006744 (ubiquinone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Primase-associated factor LEF-2 (P41418)
Organism: Autographa californica nuclear polyhedrosis virus (AcMNPV)
Function: Plays an essential role in viral DNA replication. Does not seem to participate in the initiation step but is rather important for the amplification of DNA. Also required for expression from the vp39 and polh promoters.
Subcellular location: Virion {ECO:0000269|PubMed:20219928}. Host nucleus {ECO:0000269|PubMed:20219928}. Host cytoplasm {ECO:0000269|PubMed:20219928}. Note=Colocalizes with the active viral DNA replication sites in the nucleus of infected cells. {ECO:0000269|PubMed:9060674}.
Sequence: MANASYNVWSPLIRASCLDKKATYLIDPDDFIDKLTLTPYTVFYNGGVLVKISGLRLYMLLTAPPTINEIKNSNFKKRSKRNICMKECVEGKKNVVDMLNNKINMPPCIKKILNDLKENNVPRGGMYRKRFILNCYIANVVSCAKCENRCLIKALTHFYNHDSKCVGEVMHLLIKSQDVYKPPNCQKMKTVDKLCPFAGNCKGLNPICNY
InterPro domains: - IPR004283: Late expression factor 2 (family) [7-171]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019079 (viral genome replication), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Probable transport accessory protein MmpS2 (P9WJT3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
Sequence: MISVSGAVKRMWLLLAIVVVAVVGGLGIYRLHSIFGVHEQPTVMVKPDFDVPLFNPKRVTYEVFGPAKTAKIAYLDPDARVHRLDSVSLPWSVTVETTLPAVSVNLMAQSNADVISCRIIVNGAVKDERSETSPRALTSCQVSSG
InterPro domains: - IPR038468: Transport accessory protein MmpS, C-terminal (homologous_superfamily) [57-145]
- IPR008693: Transport accessory protein MmpS (family) [8-144]
Interaction partners: - Probable transport protein MmpL2
- Uncharacterized protein Rv0508
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0052553 (modulation by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)