Protein: LAS seventeen-binding protein 5 (LAS17-binding protein 5) (P25369)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with YSC84.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:12388763}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12388763}. Note=Localizes independently of F-actin.
Sequence: MGFLSDHPHTAITETIFRIVSSRDYTLEVELAPLIQLIKADHNDYNYTVNQEEAARALRKKIKYGNRLQQSRTLDLLDLFISQGVKFTVMYNDDKLLQRLRGMATNSENSGSGEKYEPRIIKKCAAYAISWLNYITQNNLENARAYSGLYQLGQTVKQRYSKSSRSRRSGGGSGGRSNFMDDSADDTLYQSNSLTSADRLYRIPQINMNKEAPRIRLIISDALASAVSLQNSLIGLPKGKFSTDDEEATSKFIQARAIRRKVLRYLQLVTEGEFLGSLIHANDELVAALTAYDDRSAQDDSSDESDHGSYDDGIYDENEQDNSRYIDSESSEEESLSSYQPSTISNPFGDHNKI
InterPro domains: - IPR045007: LAS seventeen-binding protein 5 (family) [1-164]
- IPR044103: LAS seventeen-binding protein 5 , GAT domain (domain) [219-295]
- IPR008942: ENTH/VHS (homologous_superfamily) [5-169]
Interaction partners: - Protein YSC84
- ADP-ribosylation factor 3
- Actin cytoskeleton-regulatory complex protein SLA1
- ADP-ribosylation factor-like protein 1
- Protein GTS1
- Proline-rich protein LAS17
- LAS seventeen-binding protein 3
- Myosin tail region-interacting protein MTI1
- Altered inheritance of mitochondria protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0006914 (autophagy), GO:0046907 (intracellular transport), GO:0032258 (cytoplasm to vacuole transport by the Cvt pathway), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0045184 (establishment of protein localization), GO:0016236 (macroautophagy), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0044804 (autophagy of nucleus), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0006623 (protein targeting to vacuole), GO:0072665 (protein localization to vacuole)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0036452 (ESCRT complex), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle)