Protein: Integrin beta (E9PEE8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell junction, focal adhesion {ECO:0000256|ARBA:ARBA00004246}. Cell membrane {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
Sequence: MITYKNFTHPSGVGERCDTPANLLAKGCQLNFIENPVSQVEILKNKPLSVGRQKNSSDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTPEEIANPCSSIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDSKNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWTGEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEEDFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKQKVDLSTDC
InterPro domains: - IPR014836: Integrin beta subunit, cytoplasmic domain (domain) [689-735]
- IPR013111: Epidermal growth factor-like domain, extracellular (domain) [502-572]
- IPR012896: Integrin beta subunit, tail (domain) [580-665]
- IPR057243: Integrins beta, I-EGF domain, conserved site (conserved_site) [549-562]
- IPR002369: Integrin beta subunit, VWA domain (domain) [2-412]
- IPR040622: Integrin beta, epidermal growth factor-like domain 1 (domain) [414-443]
- IPR057073: Integrin beta, epidermal growth factor-like domain 2 (domain) [457-496]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [38-416]
- IPR036349: Integrin beta tail domain superfamily (homologous_superfamily) [580-663]
- IPR015812: Integrin beta subunit (family) [4-740]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [86-333]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0098772 (molecular function regulator activity), GO:0005515 (protein binding), GO:0140677 (molecular function activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0033627 (cell adhesion mediated by integrin), GO:0001817 (regulation of cytokine production), GO:0010646 (regulation of cell communication), GO:0010468 (regulation of gene expression), GO:0071634 (regulation of transforming growth factor beta production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0043235 (receptor complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0098636 (protein complex involved in cell adhesion), GO:0098802 (plasma membrane signaling receptor complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0098797 (plasma membrane protein complex), GO:0043233 (organelle lumen), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0008305 (integrin complex), GO:0005886 (plasma membrane), GO:0030055 (cell-substrate junction), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005925 (focal adhesion), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0015630 (microtubule cytoskeleton)