Protein: Extracellular signal-regulated kinase 2 (ERK2) (EC 2.7.11.24) (Defective in aggregation protein C) (MAP kinase 2) (Q54QB1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase.
Sequence: MSSEDIDKHVLRKYEVLQKIGKGAYGIVWKAIDKKTKQTVALKKIFDAFQNATDAQRTFREIMFLQELHGHENIIKLLNVIKADNDRDIYLVFEHMETDLHAVIRAKILEEIHKQYTIYQLLKALKYMHSANVLHRDIKPSNLLLNSECLVKVADFGLARSITSLESIAEANPVLTEYVATRWYRAPEILLGSTKYTKGVDMWSIGCILGELLGEKAMFPGNSTMNQLDLIIEVTGRPSAEDIEAIKSPFAGTMLESLPPSNPRSLSDMYPSASVDALDLLKKLLQFNPDKRITAEEALAHPFVTQFHNPAEEPHFDRIIKISIDDGQKFPIAEYRNRLYNDIIKKKKEERKKQTNPTKPDTTAPTLST
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [8-312]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [133-145]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [12-347]
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [49-149]
- IPR017441: Protein kinase, ATP binding site (binding_site) [20-43]
- IPR000719: Protein kinase domain (domain) [14-304]
Interaction partners: - Gelation factor
- Ras-like protein rasD
- 3',5'-cyclic-nucleotide phosphodiesterase regA
- Gelsolin-related protein of 125 kDa
- Cyclic AMP receptor 1
- Dual specificity mitogen-activated protein kinase kinase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)