Protein: Cytochrome P450 2J6 (EC 1.14.14.1) (Arachidonic acid epoxygenase) (CYPIIJ6) (O54750)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence: MLAATGSLLATIWAALHPRTLLVAAVTFLLLADYFKNRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQPLVKKYGNIFSLNLGDITSVVITGLPLIKEALTQMEQNIMNRPLSVMQERISNKNGLIFSSGQIWKEQRRFALMTLRNFGLGKKSLEERMQEEASHLVEAIREEEGKPFNPHFSINNAVSNIICSVTFGERFDYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIPGSHQKVFRNWEKLKLFVSCMIDDHRKDWNPDEPRDFIDAFLKEMTKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAARLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTNLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFTFNPPINEKLSPKFRNGLTLSPVSHRICAVPRQ
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [34-501]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [440-449]
- IPR001128: Cytochrome P450 (family) [44-496]
- IPR002401: Cytochrome P450, E-class, group I (family) [72-470]
- IPR050182: Cytochrome P450 family 2 (family) [24-475]
- IPR008071: Cytochrome P450, E-class, group I, CYP2J-like (family) [16-499]
Interaction partners: - Polyunsaturated fatty acid lipoxygenase ALOX15
- Cytochrome P450 1A2
- Polyunsaturated fatty acid 5-lipoxygenase
- Prostaglandin G/H synthase 2
- Prostaglandin G/H synthase 1
- Bifunctional epoxide hydrolase 2
- Cytochrome P450 2E1
- Cytochrome P450 2U1
- Polyunsaturated fatty acid lipoxygenase ALOX12
- Arachidonate 12-lipoxygenase, 12R-type
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0008391 (arachidonic acid monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051094 (positive regulation of developmental process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0120254 (olefinic compound metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0044255 (cellular lipid metabolic process), GO:0001708 (cell fate specification), GO:0006066 (alcohol metabolic process), GO:0035107 (appendage morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:2000026 (regulation of multicellular organismal development), GO:0006629 (lipid metabolic process), GO:0009888 (tissue development), GO:0006082 (organic acid metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0051962 (positive regulation of nervous system development), GO:0072001 (renal system development), GO:0019369 (arachidonic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0051493 (regulation of cytoskeleton organization), GO:0043436 (oxoacid metabolic process), GO:0001944 (vasculature development), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0030855 (epithelial cell differentiation), GO:0019369 (arachidonic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0022008 (neurogenesis), GO:0030323 (respiratory tube development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0002064 (epithelial cell development), GO:0072359 (circulatory system development), GO:0007507 (heart development), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0019752 (carboxylic acid metabolic process), GO:0043009 (chordate embryonic development), GO:0048713 (regulation of oligodendrocyte differentiation), GO:0014015 (positive regulation of gliogenesis), GO:0045687 (positive regulation of glial cell differentiation), GO:0050767 (regulation of neurogenesis), GO:0033559 (unsaturated fatty acid metabolic process), GO:0050767 (regulation of neurogenesis), GO:0001676 (long-chain fatty acid metabolic process), GO:0072073 (kidney epithelium development), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0048714 (positive regulation of oligodendrocyte differentiation), GO:0032787 (monocarboxylic acid metabolic process), GO:0006690 (icosanoid metabolic process), GO:0018105 (peptidyl-serine phosphorylation), GO:0018209 (peptidyl-serine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)