Protein: A disintegrin and metalloproteinase with thrombospondin motifs 13 (A0A286Y999)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MQQPNMENVFWLFLVLSLLTAVFSKSSVLISQCTLQKDFLDSLKPQDLFYYFDTISTKSVPPFEIVWVNCSRNESIKGLWRCLFQTKGESFELVQHSAKQAVSCPTSLEMIINSTVSMVKKREDMCCEQLKLLRPTHTRTLLPVCYGKLQGLIQSGEMRLYIRPVLEQHIDNLKDLTMDLPPGVPHLLITQTLPVRTRLKQPKSQFRLRRSPLRSEVTYLELAVVVGPDVYEVHRQDTERYILTNLNIASELLRDVTLGANIRVHLVRMIILTEPEPDIQISENITSSLKSVCEWGQKVNPDADSDPLHADLLLYITRFDLVLPNGNKLVRGVTQFGGVCSTQWNCVITEDTGFDLGITIAHEIGHSFGINHDGIDNTCSSSGFMMASDGGYNSVDLTWSQCSRAQLYSFFRAGKAECVQDVPVLGGSVQDWRPGLFYGVDDQCRIAFGSSATACSFTNEDMTTCRVLSCHINPQDHSSCTRLLVPLLDGTECGPSQWCLKGRCVSPSTSGSSMMVHGSWSAWSDFSPCSRTCGGGITHRRRQCNNPRSAFGGTICKGQNTEAELCNLQLCDSTQLEFMARQCSATDQQPLSVSTDSKSMYTWIPAISYSSGDSQCKLMCRSREQDFMVSRGSQFIDGTRCESDNPVPHGSISACLSGKCQLFGCDGALHSGKVEDVCGVCGGNGSTCHLISNTYSGGKAGEYVTFLTLPLNASQVHVFNTRSIFTHLAVLLNDKYVVSGNGKPGLSNTYPSPLEKSLITYKLYLTPDHLPQTEELYISGPVTDKIHLQVYRKYGQEYGDLTNPNISYQYYSDDVIVEIASKGKWSTTISACSVTCGRGIQKIYQHCVDLVTLEHLKDELCSSLPRSSDLLQPCFLPDCPPRWQVSEPGECSTVCGPGEAQRKVFCVRFHNKSYLEVDQNLCSQPKPPEYVPCVVDVCPLKWDTENETQLIHRASHGMVRSKIVPVYVWSPRTGECSKTCGNGSQQVQFSCVDHKSRLEVPETLCDPTTKPAQDTQPCRISLCLPIWRYIQGPCSVSCGGGIAKRVLFCSQRMEENDGNNDLVVGETACDSVPKPPEVVECNTEKCKARWQVGDQGDCSVTCGMGVALRSVQCVQYEGGVERDVEEEKCESETKPPVTVPCFTQVCSFNWDVHDWSKCSVSCGYGIQSRAVSCMGPSNPFPLSPFLCLHLPKPITIQACYSPDCSSVNTSESKPNSTYIQSTLQSIEGMWKSPNMQTTPAPAVRRIKMKKSFPTIVPTADMMTSTMSVPTETPQTSICGQLLLQDSGNIDLRNVTERRCIFAIGRPLDEVIQIRIISSTLNCQQKENIALYDRLVLMRLCERMTGKMVKSRTNVLLVRQNRLTSGNGVVLFYQSVKTNKGYNRVCDVQLFAPSGLIENPIKSPATYPSNTQSCRVFIDAPPALRVQIRALSVLNNTDTNSTYILIRDVDALKTTIFRGTQLFLWRSSGSRAEVEFHGEYQQIKGMFRAEYLHINPSEE
InterPro domains: - IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [215-423]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [517-1205]
- IPR035914: Spermadhesin, CUB domain superfamily (homologous_superfamily) [1274-1492]
- IPR041645: ADAMTS, cysteine-rich domain 2 (domain) [434-505]
- IPR045371: ADAMTS/ADAMTS-like, cysteine-rich domain 3 (domain) [574-688]
- IPR010294: ADAMTS/ADAMTS-like, Spacer 1 (domain) [691-811]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [218-423]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [515-1204]
- IPR013273: ADAMTS/ADAMTS-like (family) [526-688]
- IPR000859: CUB domain (domain) [1385-1493]
- IPR050439: ADAMTS and ADAMTS-like (family) [241-1081]
Interaction partners: - von Willebrand factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0035239 (tube morphogenesis), GO:0009057 (macromolecule catabolic process), GO:0051216 (cartilage development), GO:0048514 (blood vessel morphogenesis), GO:0001501 (skeletal system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0061448 (connective tissue development), GO:0060537 (muscle tissue development), GO:0030855 (epithelial cell differentiation), GO:0060429 (epithelium development), GO:0060837 (blood vessel endothelial cell differentiation), GO:0003158 (endothelium development), GO:0045446 (endothelial cell differentiation), GO:0001885 (endothelial cell development), GO:0003158 (endothelium development), GO:0051603 (proteolysis involved in protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)