Protein: Interleukin-31 (IL-31) (Q6EBC2)
Organism: Homo sapiens (Human)
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Sequence: MASHSGPSTSVLFLFCCLGGWLASHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
InterPro domains: - IPR027987: Interleukin-31 (family) [1-164]
Interaction partners: - Oncostatin-M-specific receptor subunit beta
- Interleukin-31 receptor subunit alpha
- Oncostatin-M
- Interleukin-13
- Tyrosine-protein kinase JAK1
- Interleukin-17A
- Thymic stromal lymphopoietin
- Interferon gamma
- Interleukin-4
- Interleukin-11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0070851 (growth factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0050900 (leukocyte migration), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0002694 (regulation of leukocyte activation), GO:0001817 (regulation of cytokine production), GO:0002697 (regulation of immune effector process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0006935 (chemotaxis), GO:0050865 (regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0097529 (myeloid leukocyte migration), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0045785 (positive regulation of cell adhesion), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0009891 (positive regulation of biosynthetic process), GO:0050867 (positive regulation of cell activation), GO:0098542 (defense response to other organism), GO:0002696 (positive regulation of leukocyte activation), GO:0042127 (regulation of cell population proliferation), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0009617 (response to bacterium), GO:0009889 (regulation of biosynthetic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022409 (positive regulation of cell-cell adhesion), GO:0002703 (regulation of leukocyte mediated immunity), GO:0051246 (regulation of protein metabolic process), GO:0022407 (regulation of cell-cell adhesion), GO:0002237 (response to molecule of bacterial origin), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0070663 (regulation of leukocyte proliferation), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0010468 (regulation of gene expression), GO:0051251 (positive regulation of lymphocyte activation), GO:0050729 (positive regulation of inflammatory response), GO:0032740 (positive regulation of interleukin-17 production), GO:0051251 (positive regulation of lymphocyte activation), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0070665 (positive regulation of leukocyte proliferation), GO:0051252 (regulation of RNA metabolic process), GO:0070665 (positive regulation of leukocyte proliferation), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0019221 (cytokine-mediated signaling pathway), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0034097 (response to cytokine), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:0010628 (positive regulation of gene expression), GO:1904894 (positive regulation of receptor signaling pathway via STAT), GO:0032660 (regulation of interleukin-17 production), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0006954 (inflammatory response), GO:0050727 (regulation of inflammatory response), GO:0042742 (defense response to bacterium), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0002821 (positive regulation of adaptive immune response), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0002637 (regulation of immunoglobulin production), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0050670 (regulation of lymphocyte proliferation), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0071345 (cellular response to cytokine stimulus), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0043549 (regulation of kinase activity), GO:0051896 (regulation of protein kinase B signaling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0050864 (regulation of B cell activation), GO:0050871 (positive regulation of B cell activation), GO:0031401 (positive regulation of protein modification process), GO:0050870 (positive regulation of T cell activation), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0031399 (regulation of protein modification process), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0006355 (regulation of DNA-templated transcription), GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0032816 (positive regulation of natural killer cell activation), GO:1901224 (positive regulation of NIK/NF-kappaB signaling), GO:0002706 (regulation of lymphocyte mediated immunity), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0002709 (regulation of T cell mediated immunity), GO:0042325 (regulation of phosphorylation), GO:0042102 (positive regulation of T cell proliferation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0002825 (regulation of T-helper 1 type immune response), GO:0002230 (positive regulation of defense response to virus by host), GO:0042129 (regulation of T cell proliferation), GO:0002711 (positive regulation of T cell mediated immunity), GO:0002712 (regulation of B cell mediated immunity), GO:0042509 (regulation of tyrosine phosphorylation of STAT protein), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0045860 (positive regulation of protein kinase activity), GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein), GO:0032147 (activation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)