Protein: LD07278p (Q9W4G1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MEWSLIISILLNCLYASASALDEDCPTLDDGDSLSQTQLLDRLTHGCRYDRLERPITYSETGQRLPVDVYMRAYIYFMQNLEAHDLQFKIYALLQMRYLDPRLNFRNVSPKRRQPILGEEHLRNSLWMPHIFLANERDSSILGLTEKDILTSISPDGTVIVSNRIKATLYCWLNLKKFPFDEQHCSTVLESWMYNTSELVLHWEQKRPITYDGALHLTEFVLQRSWSNETVINADLSDLRHGAFAGNYSSLSFTVHLTRVVGFYLMDYFLPSMLIVAISWVSFWLQADQAPPRITLGTSTLLTFITLASAQGKTLPKVSYIKVSEVWFLGCTIFIFGSMVEFAFVNTIWRRKKSVPVKKLNSKHILKSTLSPNLLRRRSHARSRSFSGTALHKTADTGSLGGAGFNNYLTVNLPITTIKEGQVLDQQRTSRVVQKMDVNFVESAFGSMGSAQSTGAISAASSSQTLTNNNRTESAGHQEEIDLSGWTTLTPQEIAMWIDSRARFVFPLSFLVFNLFFWTFVYCI
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [259-524]
- IPR006201: Neurotransmitter-gated ion-channel (family) [37-386]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [29-259]
- IPR006028: Gamma-aminobutyric acid A receptor/Glycine receptor alpha (family) [264-521]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [171-185]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [262-523]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [270-518]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [36-259]
Interaction partners: - Mitosis initiation protein fs
- CG5272 protein
- Chorion peroxidase
- Deubiquitinase otu
- Maternal effect protein oskar
- Female sterile
- Tubulin alpha-4 chain
- LD24340p
- EG:8D8.1 protein
- Protein swallow
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0030594 (neurotransmitter receptor activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0005216 (monoatomic ion channel activity), GO:0015108 (chloride transmembrane transporter activity), GO:0022835 (transmitter-gated channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0005253 (monoatomic anion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005254 (chloride channel activity), GO:0099095 (ligand-gated monoatomic anion channel activity), GO:0061797 (pH-gated chloride channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0042752 (regulation of circadian rhythm), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0010648 (negative regulation of cell communication), GO:0099536 (synaptic signaling), GO:0010646 (regulation of cell communication), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0031645 (negative regulation of nervous system process), GO:0098908 (regulation of neuronal action potential), GO:0070633 (transepithelial transport), GO:0051969 (regulation of transmission of nerve impulse), GO:0031644 (regulation of nervous system process), GO:0099537 (trans-synaptic signaling), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0098916 (anterograde trans-synaptic signaling), GO:0006820 (monoatomic anion transport), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0098862 (cluster of actin-based cell projections), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005903 (brush border), GO:0016324 (apical plasma membrane), GO:0005773 (vacuole), GO:0098590 (plasma membrane region), GO:1902495 (transmembrane transporter complex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005770 (late endosome), GO:0031526 (brush border membrane), GO:0005774 (vacuolar membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0031902 (late endosome membrane), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)