Protein: Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] (P00786)
Organism: Rattus norvegicus (Rat)
Function: Important for the overall degradation of proteins in lysosomes.
Subcellular location: Lysosome.
Sequence: MWTALPLLCAGAWLLSAGATAELTVNAIEKFHFTSWMKQHQKTYSSREYSHRLQVFANNWRKIQAHNQRNHTFKMGLNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMMTLAEQQLVDCAQNFNNHGCQGGLPSQAFEYILYNKGIMGEDSYPYIGKNGQCKFNPEKAVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFMMYKSGVYSSNSCHKTPDKVNHAVLAVGYGEQNGLLYWIVKNSWGSNWGNNGYFLIERGKNMCGLAACASYPIPQV
InterPro domains: - IPR013128: Peptidase C1A (family) [29-324]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [294-313]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [133-144]
- IPR039417: Papain-like cysteine endopeptidase (domain) [115-329]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [114-330]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [30-331]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [277-287]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [33-88]
Interaction partners: - Apoptosis regulator Bcl-2
- BH3-interacting domain death agonist
- Bcl-2-like protein 1
- Napsin A aspartic peptidase, isoform CRA_a
- Pulmonary surfactant-associated protein B
- Surfactant protein C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0033218 (amide binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0042277 (peptide binding), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:1901565 (organonitrogen compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)