Protein: Biogenesis of lysosome-related organelles complex-1 subunit 2 (BLOC-1 subunit 2) (Spinal cord-expressed protein 1) (Q32WR5)
Organism: Rattus norvegicus (Rat)
Function: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6QNY1}. Lysosome membrane {ECO:0000250|UniProtKB:Q6QNY1}. Note=Localizes to the centrosomes in a microtubule-dependent manner. {ECO:0000250|UniProtKB:Q6QNY1}.
Sequence: MAAAAEGVPATRREEPPRDDAAVETAEEAKEPAEADINELCRDMFSKMATYLTGELTATSEDYKLLENMNKLTSLKYLEMKDIAINISRNLKDLNQKYAGLQPYLDQINVIEEQVAALEQAAYKLDAYSKKLEAKYKKLEKR
InterPro domains: - IPR019269: Biogenesis of lysosome-related organelles complex-1, subunit 2 (family) [12-142]
Interaction partners: - Biogenesis of lysosome-related organelles complex 1 subunit 1
- SNARE-associated protein Snapin
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- Dysbindin
- BLOC-1 related complex subunit 8
- KxDL motif-containing protein 1
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Biogenesis of lysosomal organelles complex 1 subunit 4
- BLOC-1-related complex subunit 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0051222 (positive regulation of protein transport), GO:1903532 (positive regulation of secretion by cell), GO:0060341 (regulation of cellular localization), GO:0051046 (regulation of secretion), GO:0051223 (regulation of protein transport), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:1904951 (positive regulation of establishment of protein localization), GO:0050714 (positive regulation of protein secretion), GO:0070201 (regulation of establishment of protein localization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0031082 (BLOC complex), GO:0031083 (BLOC-1 complex)