Protein: Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein) (Q86X45)
Organism: Homo sapiens (Human)
Function: Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia. Acts as a crucial component in the formation and motility of spermatozoal flagella.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23122589, ECO:0000269|PubMed:23527195, ECO:0000269|PubMed:33403504}. Cell projection, cilium {ECO:0000269|PubMed:23122589}. Dynein axonemal particle {ECO:0000250|UniProtKB:A0A1L8G016}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:33403504}.
Sequence: MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKPDSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDPSKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [1-174]
- IPR007052: CS domain (domain) [301-396]
- IPR003603: U2A'/phosphoprotein 32 family A, C-terminal (domain) [128-146]
- IPR056496: Dynein axonemal assembly factor 11-like, CS domain (domain) [261-380]
- IPR001611: Leucine-rich repeat (repeat) [45-88]
Interaction partners: - Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 3
- Dynein axonemal intermediate chain 1
- Dynein axonemal assembly factor 6
- Dynein axonemal assembly factor 5
- Dynein axonemal assembly factor 19
- Coiled-coil domain-containing protein 39
- Dynein axonemal assembly factor 4
- Coiled-coil domain-containing protein 40
- Sperm-associated antigen 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0006725 (cellular aromatic compound metabolic process), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)