Protein: Phosphoprotein OPG062 (P07396)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Plays an essential role in virion assembly and morphogenesis. Also plays a role in the inhibition of host immune response by dysregulating mTOR. Sequesters host RICTOR and RPTOR, thereby disrupting mTORC1 and mTORC2 crosstalk. In turn, blocks the host antiviral response in part through mTOR-dependent degradation of cGAS, the primary poxvirus sensor
Subcellular location: Virion. Note=Major component of the virion comprising about 10% of the virion mass
Sequence: MNSHFASAHTPFYINTKEGRYLVLKAVKVCDVRTVECEGSKASCVLKVDKPSSPACERRPSSPSRCERMNNPRKQVPFMRTDMLQNMFAANRDNVASRLLN
InterPro domains: - IPR006854: Phosphoprotein F17 (family) [1-101]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0009605 (response to external stimulus), GO:0044068 (modulation by symbiont of host cellular process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0035821 (modulation of process of another organism), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075528 (modulation by virus of host immune response), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0075136 (response to host), GO:0039503 (suppression by virus of host innate immune response), GO:0019054 (modulation by virus of host cellular process), GO:0031348 (negative regulation of defense response), GO:0044414 (suppression of host defenses by symbiont), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0052031 (modulation by symbiont of host defense response), GO:0019049 (mitigation of host antiviral defense response), GO:0052170 (suppression by symbiont of host innate immune response), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response), GO:0052562 (suppression by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)