Protein: rRNA-processing protein EFG1 (Exit from G1 protein 1) (Q3E705)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in rRNA processing. Required growth at elevated temperatures, resistance to hydroxyurea and for cell cycle progression.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Sequence: MAKLQRKRSKALGSSLEMSQIMDAGTNKIKRRIRDLERLLKKKKDILPSTVIIEKERNLQALRLELQNNELKNKIKANAKKYHMVRFFEKKKALRKYNRLLKKIKESGADDKDLQQKLRATKIELCYVINFPKTEKYIALYPNDTPSTDPKGVELTNLRREQFLKLVAERMDANTLNVSFEEILKGKKLDEDSIGLTLSPDKDHEDGSQVSPTQDRKELDQVVGEDEKDDFFE
InterPro domains: - IPR019310: rRNA-processing protein Efg1 (family) [29-141]
- IPR050786: EFG1 rRNA-processing (family) [6-218]
Interaction partners: - Essential nuclear protein 1
- ATP-dependent RNA helicase FAL1
- Nucleolar protein 9
- Protein SOK2
- KRR1 small subunit processome component
- U3 small nucleolar RNA-associated protein 7
- Nucleolar complex protein 14
- Protein LTV1
- Dimethyladenosine transferase
- Bud site selection protein 22
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0019843 (rRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0042274 (ribosomal small subunit biogenesis), GO:0016070 (RNA metabolic process), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0006396 (RNA processing), GO:0042254 (ribosome biogenesis), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0034470 (ncRNA processing), GO:0030490 (maturation of SSU-rRNA), GO:0006364 (rRNA processing), GO:0036260 (RNA capping), GO:0000966 (RNA 5'-end processing), GO:0034660 (ncRNA metabolic process), GO:0000460 (maturation of 5.8S rRNA), GO:0000469 (cleavage involved in rRNA processing), GO:0000967 (rRNA 5'-end processing), GO:0000462 (maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0034471 (ncRNA 5'-end processing), GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic), GO:0016072 (rRNA metabolic process), GO:0000478 (endonucleolytic cleavage involved in rRNA processing), GO:0000447 (endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000472 (endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000480 (endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000466 (maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000479 (endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA))
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)