Protein: Cysteine/serine-rich nuclear protein 1 (CSRNP-1) (Axin-1 up-regulated gene 1 protein) (TGF-beta-induced apoptosis protein 3) (TAIP-3) (P59054)
Organism: Mus musculus (Mouse)
Function: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:17726538}.
Sequence: MTGLLKRKFDQLEEDDSSSSSSSSFSSRLSLSSFPASSASPAWNSDEEGPGGQAPQSDQDSCGLQSFTPPSILKRAPRERPGHVAFNGITVYYFPRCQGFTSVPSRGGCTLGMASRHSTCRLFSLAEFTQEQVRARREKLRRRLKEEKLEMLRWKFSVAGVPESGAGVPLTADAIDDASVEEDLAVAVANGRLEEANFLQPHPPRQRRALLRASGVRRIDREEKRELQVLRQSREDCGCHCDGVCDPETCSCSLAGIKCQMDHTSFPCGCCREGCENPNGRVEFNQTRVQTHFIHTLTRLQMEQGAESLGDLESPVEDTPVEQAALSPFPPSKPPVSSELGDSSCSSDMTDSSTTLSSGSSEPPNHPAHPSLPGPSFRSGVDEDSLEQILNFSDSDLGIEEEEEEGGGVGNLDNLSCFHLADIFGTGDPGSLASWTHSQSGSSLASGILDENANLDASCFLNSGLGGLREGSLPGSSGSPEGDAVQSSSWDLSLSSCDSFELLQALPDYSLGPHYTSRRVSGSPDSLETFHPLPSFSPPRDASTCFLESLVGLSEPVTEVLAPLLESQFEDAALAPLLEPVPV
InterPro domains: - IPR031972: Cysteine/serine-rich nuclear protein, N-terminal domain (domain) [82-304]
- IPR023260: Cysteine/serine-rich nuclear protein family (family) [1-577]
Interaction partners: - Homeobox protein MSX-1
- Growth arrest and DNA damage-inducible protein GADD45 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0010941 (regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)