Protein: NAD-dependent histone deacetylase HST3 (Q5A1W9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability
Subcellular location: Cytoplasm. Nucleus
Sequence: MISIDLLDNSGTSMPADTSIKLHEVIKFISKSKKMTVLTGAGISCNAGIPDFRSSDGLYNMVKAKHPKAVVRGQDLFDISLFRDEMSLSVFCTFMESLYKSSLNAKPTETHKFIKILKDKNKLLRCYTQNIDCIEQHINLKLGINLQEFDNNKFKQVWNQLDVVQLHGNLHKLSCTNCFSQFNWNEEFQTLLANGLNPECSKCMDKYQQRLYSGKRLTGQTIGLLRPDIVLYGEHHPQMEILTQGLNSDLKSRPDCLIIMGTSLKVAGVKSLVKSLSKIIHNKGGKVIYVNKTKLSASSWKNYIDYEVVSDCDEFVRMLKTEIPDLFLTQEQLDSEKLNQVAVKGSSLNKPIVKPEAKVKIEPGIKQEDAIQYSPEREVTIKQEVNIKQEPIVKREVESVSVKEEPIPTPPTTPHKPKQATKLKRKSPDEISANEVHSRVKRLRPRNDQLSSPASSINGSEEEEEEDEPVAKVLFENARKGITLDQH
InterPro domains: - IPR026591: Sirtuin, catalytic core small domain superfamily (homologous_superfamily) [46-237]
- IPR029035: DHS-like NAD/FAD-binding domain superfamily (homologous_superfamily) [13-335]
- IPR003000: Sirtuin family (family) [40-267]
- IPR026590: Sirtuin family, catalytic core domain (domain) [15-336]
- IPR050134: NAD-dependent sirtuin protein deacylases (family) [21-330]
Interaction partners: - Nicotinamide-nucleotide adenylyltransferase
- nicotinamidase
- Glutamine-dependent NAD(+) synthetase
- NADH/NAD(+) kinase
- Histone acetyltransferase RTT109
- Trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
- Purine nucleoside phosphorylase
- NAD(+) diphosphatase
- Nicotinamide-nucleotide adenylyltransferase
- Histone H3.1/H3.2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides), GO:0034979 (NAD-dependent protein deacetylase activity), GO:0017136 (NAD-dependent histone deacetylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019222 (regulation of metabolic process), GO:0045927 (positive regulation of growth), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0010570 (regulation of filamentous growth), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0009991 (response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0010468 (regulation of gene expression), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0031669 (cellular response to nutrient levels), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)