Protein: Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Protein-tyrosine phosphatase-like member A) (Q9QY80)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:B0YJ81}; Multi-pass membrane protein {ECO:0000250|UniProtKB:B0YJ81}.
Sequence: MGKGDWRQGRVEMPCAHVSRLHKTCVQVRVRVTMASSEEDGTNGASEASDEKEAAGKRRRLGLLATAWLTFYNIAMTAGWLVLAIAMVRFYMEKGTHRGLYKSIQKTLKFFQTFALLEVVHCLIGIVPTSVLVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVSWTVTEITRYSFYTFSLLDHLPHFIKWARYNLFIILYPVGVAGELLTIYAALPYVKKSGMFSVRLPNKYNVSFDYYYFLLITMASYIPLFPQLYFHMLRQRRKVLHGEVIAEKDD
InterPro domains: - IPR007482: Protein-tyrosine phosphatase-like, PTPLA (family) [52-272]
Interaction partners: - Very-long-chain enoyl-CoA reductase
- Very-long-chain 3-oxoacyl-CoA reductase
- Very long chain fatty acid elongase 2
- Very long chain fatty acid elongase 4
- Acyl-CoA
- Very-long-chain
- Very long chain fatty acid elongase 5
- Very-long-chain
- Very-long-chain
- Trans-2,3-enoyl-CoA reductase-like
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity), GO:0004300 (enoyl-CoA hydratase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0048513 (animal organ development), GO:0030155 (regulation of cell adhesion), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0045785 (positive regulation of cell adhesion), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0016043 (cellular component organization), GO:0043603 (amide metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0010811 (positive regulation of cell-substrate adhesion), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0010810 (regulation of cell-substrate adhesion), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042476 (odontogenesis), GO:0043604 (amide biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0035384 (thioester biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006631 (fatty acid metabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0031214 (biomineral tissue development), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0043933 (protein-containing complex organization), GO:1901568 (fatty acid derivative metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0035337 (fatty-acyl-CoA metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0065003 (protein-containing complex assembly), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0030148 (sphingolipid biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0034505 (tooth mineralization), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0071616 (acyl-CoA biosynthetic process), GO:1901570 (fatty acid derivative biosynthetic process), GO:0000038 (very long-chain fatty acid metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0034033 (purine nucleoside bisphosphate biosynthetic process), GO:0046949 (fatty-acyl-CoA biosynthetic process), GO:0033875 (ribonucleoside bisphosphate metabolic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0009165 (nucleotide biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0030497 (fatty acid elongation), GO:0033866 (nucleoside bisphosphate biosynthetic process), GO:0035338 (long-chain fatty-acyl-CoA biosynthetic process), GO:0034030 (ribonucleoside bisphosphate biosynthetic process), GO:0009152 (purine ribonucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)