Protein: Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3) (Q6QBQ4)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (By similarity). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:29171872}; Single-pass type II membrane protein {ECO:0000305|PubMed:29171872}. Nucleus {ECO:0000250|UniProtKB:Q9JIZ9}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9JIZ9}.
Sequence: MAGYLPPKGYAPSPPPPYPVPAGYPEAAALHPGPGQAPVPTQGPAPAPGFSLFPSPGPVVPGPPGPFVPLPGVPSGLEFLVQIDQILIHQKAERVETFLGWETCNRYELRSGTGQQLGQAAEESNCCARLCCGARRPLRIRLADPGDREVLRLLRPLHCGCSCCPCGLQEMEVQAPPGTTIGHVLQTWHPFIPKFSILDADRQPVLRVVGPCCTCGCGTDTNFEVKTKDESRSVGRISKQWGGLLREALTDADDFGLQFPVDLDVRVKAVLLGATFLIDYMFFEKRGGAGPSAITS
InterPro domains: - IPR005552: Scramblase (family) [29-292]
Interaction partners: - Calcium homeostasis endoplasmic reticulum protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0006955 (immune response), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0050776 (regulation of immune response), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0097035 (regulation of membrane lipid distribution), GO:0009966 (regulation of signal transduction), GO:0016043 (cellular component organization), GO:0002694 (regulation of leukocyte activation), GO:0050865 (regulation of cell activation), GO:0006869 (lipid transport), GO:0034204 (lipid translocation), GO:0010256 (endomembrane system organization), GO:0033003 (regulation of mast cell activation), GO:0071702 (organic substance transport), GO:0061024 (membrane organization), GO:0015914 (phospholipid transport), GO:0045332 (phospholipid translocation), GO:0015748 (organophosphate ester transport), GO:0007009 (plasma membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)