Protein: Helix-loop-helix protein 14 (Q09961)
Organism: Caenorhabditis elegans
Function: Probable transcription factor, involved in determining neuroblast cell fate, morphogenesis and aspects of terminal differentiation in both left/right symmetric and asymmetric neuronal lineages.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14627726}.
Sequence: MAKKNQVARNERERKRVHQVNHGFDVLRNRLQPKNHTKKWSKADTLREAVKYIQQLQVLLNQDPQQPSVSSSTPDYTMNNSNNFNNYAVKEEFSMYLPQNYCPQNQMSVPHGDVSHNFNSPTSSVSSSSYSPTQMCYPPVSYSNYPHH
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [4-62]
- IPR015660: Achaete-scute transcription factor-related (family) [3-90]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [2-68]
Interaction partners: - Helix-loop-helix protein hlh-2
- Protein lin-32
- Helix-loop-helix protein lin-22
- BHLH domain-containing protein
- Helix-loop-helix protein ngn-1
- T-box protein 37
- T-box protein 38
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0046983 (protein dimerization activity), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0046982 (protein heterodimerization activity), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0071840 (cellular component organization or biogenesis), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0045165 (cell fate commitment), GO:0008038 (neuron recognition), GO:0040028 (regulation of vulval development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001708 (cell fate specification), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0040026 (positive regulation of vulval development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007413 (axonal fasciculation), GO:0007399 (nervous system development), GO:0048663 (neuron fate commitment), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0106030 (neuron projection fasciculation), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)