Protein: Protein PROCA1 (Protein interacting with cyclin A1) (Q8NCQ7)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MWVRTTLTIERWTKEKTEPKARSWDEALSDVNRLPSWERGHLLAGVASSTDVSTFSEGGDCKEPDKCCWRHKQCTGHIIYPFASDCVRHSLHLHSVNHCNCNSRLKDSSEDSSSSRGAGPTCSHVIESPCFELTPEEEHVERFRYGWCKSYRPVSVAVIHHPLYHECGADDLNEEEEEEEEESKPPIPTQVGPATASPDLGTSMATGTPDSTAPITIWRSESPTGKGQGSKVIKKVKKKKEKEKDKEEMDEKAKLKKKAKKGQLTKKKSPVKLEPSPPDVSRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKTGAKPSQARKVNKRKSPPGSNPNLS
InterPro domains: - IPR016090: Phospholipase A2-like, central domain (domain) [54-132]
- IPR036444: Phospholipase A2 domain superfamily (homologous_superfamily) [47-167]
Interaction partners: - Ubiquitin-like protein FUBI
- TBC1 domain family member 22B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0004623 (phospholipase A2 activity), GO:0004620 (phospholipase activity), GO:0047498 (calcium-dependent phospholipase A2 activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071827 (plasma lipoprotein particle organization), GO:0048523 (negative regulation of cellular process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0097006 (regulation of plasma lipoprotein particle levels), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0051047 (positive regulation of secretion), GO:0044085 (cellular component biogenesis), GO:0060548 (negative regulation of cell death), GO:0080134 (regulation of response to stress), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0002694 (regulation of leukocyte activation), GO:0006793 (phosphorus metabolic process), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0050865 (regulation of cell activation), GO:0045597 (positive regulation of cell differentiation), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0046887 (positive regulation of hormone secretion), GO:0060341 (regulation of cellular localization), GO:0019637 (organophosphate metabolic process), GO:0034369 (plasma lipoprotein particle remodeling), GO:0051130 (positive regulation of cellular component organization), GO:0010817 (regulation of hormone levels), GO:0009891 (positive regulation of biosynthetic process), GO:0050867 (positive regulation of cell activation), GO:0046883 (regulation of hormone secretion), GO:0062013 (positive regulation of small molecule metabolic process), GO:0002696 (positive regulation of leukocyte activation), GO:0006575 (cellular modified amino acid metabolic process), GO:0050776 (regulation of immune response), GO:0006629 (lipid metabolic process), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0045834 (positive regulation of lipid metabolic process), GO:1903532 (positive regulation of secretion by cell), GO:0043300 (regulation of leukocyte degranulation), GO:0031347 (regulation of defense response), GO:0030030 (cell projection organization), GO:0002703 (regulation of leukocyte mediated immunity), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0006644 (phospholipid metabolic process), GO:0033006 (regulation of mast cell activation involved in immune response), GO:2001135 (regulation of endocytic recycling), GO:0010743 (regulation of macrophage derived foam cell differentiation), GO:0006658 (phosphatidylserine metabolic process), GO:0033005 (positive regulation of mast cell activation), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0046470 (phosphatidylcholine metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0050729 (positive regulation of inflammatory response), GO:0043933 (protein-containing complex organization), GO:0033008 (positive regulation of mast cell activation involved in immune response), GO:0010744 (positive regulation of macrophage derived foam cell differentiation), GO:0010629 (negative regulation of gene expression), GO:0032386 (regulation of intracellular transport), GO:1901215 (negative regulation of neuron death), GO:0010565 (regulation of cellular ketone metabolic process), GO:0031344 (regulation of cell projection organization), GO:0033003 (regulation of mast cell activation), GO:0043302 (positive regulation of leukocyte degranulation), GO:0017157 (regulation of exocytosis), GO:0046889 (positive regulation of lipid biosynthetic process), GO:1901214 (regulation of neuron death), GO:0006796 (phosphate-containing compound metabolic process), GO:0045921 (positive regulation of exocytosis), GO:0046890 (regulation of lipid biosynthetic process), GO:0050727 (regulation of inflammatory response), GO:0031346 (positive regulation of cell projection organization), GO:0031326 (regulation of cellular biosynthetic process), GO:0051046 (regulation of secretion), GO:0019216 (regulation of lipid metabolic process), GO:0006996 (organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0042981 (regulation of apoptotic process), GO:0042304 (regulation of fatty acid biosynthetic process), GO:0071825 (protein-lipid complex subunit organization), GO:0043523 (regulation of neuron apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0002886 (regulation of myeloid leukocyte mediated immunity), GO:0044782 (cilium organization), GO:0019217 (regulation of fatty acid metabolic process), GO:0070925 (organelle assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0030031 (cell projection assembly), GO:0034367 (protein-containing complex remodeling), GO:0043066 (negative regulation of apoptotic process), GO:0010976 (positive regulation of neuron projection development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0043306 (positive regulation of mast cell degranulation), GO:0045723 (positive regulation of fatty acid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0043304 (regulation of mast cell degranulation), GO:1903307 (positive regulation of regulated secretory pathway), GO:1903305 (regulation of regulated secretory pathway), GO:0034368 (protein-lipid complex remodeling), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0010975 (regulation of neuron projection development), GO:0046337 (phosphatidylethanolamine metabolic process), GO:0060271 (cilium assembly), GO:0046488 (phosphatidylinositol metabolic process), GO:2001279 (regulation of unsaturated fatty acid biosynthetic process), GO:0046471 (phosphatidylglycerol metabolic process), GO:0046473 (phosphatidic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0070820 (tertiary granule), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0070821 (tertiary granule membrane), GO:0035579 (specific granule membrane)