Protein: LEM domain-containing protein Heh1/Lem2 (B6JYS7)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Subcellular location: Nucleus inner membrane
Sequence: MDWKDLDFNLATLRVIDLKRILSSYGISLPHNAKKVDFVNLVQQLRSQLYNQDSDEGSESLDGKESNSDTDLRYYSSSPSNSTSSPLTNSMNKEDLSDNASSPVANVRKNYDRDSNIFQKQRSSSPPDHQFTYSRRRTIANDTEPVSIKKPVHRMSMGPIEHETPRRSVTRNRKSFPFGGRYMDTSMIRTSPAFQGKVQSPTSSPLLSGSTNVKRNASEASYPVQFRREDGEEKEAITEEESGDDDDDELFKTFIRESATRDNTQKEKNVRKSDSPKGFLKRAELSLRTRSVTIYHFAVAGLKGIVYLFRKFWRITAYNTVTLSLLLVLVFVLGLWHEEVYRTGFCNVPSEAPTILRSLGIGPMCIPCPPNALCFSRLEVECKPGYILSEPWYSRLHIWPSKQCLNDSVREQNIKVFYEECLNTLRKLNARLLTKKISAETIAKNKTAVLPADIVVPSVVTAKPPSCKTAFSVAFLYDLLLSRKVPSLPVSEFNDLFAASLPLLLQTDEISMNGKLIESSSWVAIPWFTRVRRQLFLSALTYKTYILAALTIASLALLIVHKVQQTLFLRRESERIATFCLQALKQHKARYQASKVQQSAIPLMELRDIVFHAGGPMSKKRVSKHLENRLWSLVVNKLGSMATIRTREAEVEGEWTRVWEWVGVNTLNETQVN
InterPro domains: - IPR025856: HeH/LEM domain (domain) [10-44]
- IPR041885: MAN1, winged-helix domain (homologous_superfamily) [560-661]
- IPR044780: Heh2/Src1-like (family) [1-672]
- IPR018996: Man1/Src1-like, C-terminal (domain) [326-663]
Interaction partners: - Bouquet formation protein Bqt4
- Vacuolar sorting protein
- Fungal protein
- Integral inner nuclear membrane protein Ima1
- Nuclear pore complex protein Nup85
- Vacuolar-sorting protein SNF7
- Spindle pole body protein Sad1
- Nucleoporin Pom152
- Set1C complex subunit Swd1
- Ash2-trithorax family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0033036 (macromolecule localization), GO:0051640 (organelle localization), GO:0009892 (negative regulation of metabolic process), GO:0007059 (chromosome segregation), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0051656 (establishment of organelle localization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0050000 (chromosome localization), GO:0097240 (chromosome attachment to the nuclear envelope), GO:0070727 (cellular macromolecule localization), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0000278 (mitotic cell cycle), GO:0031109 (microtubule polymerization or depolymerization), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0007020 (microtubule nucleation), GO:0098813 (nuclear chromosome segregation), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0051303 (establishment of chromosome localization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0033365 (protein localization to organelle), GO:0006997 (nucleus organization), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0046785 (microtubule polymerization), GO:0034502 (protein localization to chromosome), GO:0051258 (protein polymerization), GO:0051259 (protein complex oligomerization), GO:0000280 (nuclear division), GO:0051260 (protein homooligomerization), GO:0090435 (protein localization to nuclear envelope), GO:0051291 (protein heterooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0000785 (chromatin), GO:0048471 (perinuclear region of cytoplasm), GO:0098687 (chromosomal region), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0099080 (supramolecular complex), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034506 (chromosome, centromeric core domain), GO:0043229 (intracellular organelle), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000779 (condensed chromosome, centromeric region), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome), GO:0000793 (condensed chromosome)