Protein: Transmembrane protein 132D (Mature oligodendrocytes transmembrane protein) (Mature OL transmembrane protein) (Q14C87)
Organism: Homo sapiens (Human)
Function: May serve as a cell-surface marker for oligodendrocyte differentiation.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MCPSEMGTLWHHWSPVLISLAALFSKVTEGRGILESIQRFSLLPTYLPVTYHINNADVSFFLKEANQDIMRNSSLQSRVESFLIYKSRRLPVLNASYGPFSIEQVVPQDLMLPSNPFGFTNKFSLNWKLKAHILRDKVYLSRPKVQVLFHIMGRDWDDRSAGEKLPCLRVFAFRETREVRGSCRLQGDLGLCVAELELLSSWFSPPTVVAGRRKSVDQPEGTPVELYYTVHPGGERGDCVREDARRSNGIRTGHSDIDESGPPLQRIGSIFLYQTHRKPSLRELRLDNSVAIHYIPKTVRKGDVLTFPVSISRNSTEDRFTLRAKVKKGVNIIGVRASSPSIWDVKERTDYTGKYAPAVIVCQKKAAGSENSADGASYEVMQIDVEVEEPGDLPATQLVTWQVEYPGEITSDLGVSKIYVSPKDLIGVVPLAMEAEILNTAILTGKTVAVPVKVVSVEDDGTVTELLESVECRSSDEDVIKVSDRCDYVFVNGKEMKGKVNVVVNFTYQHLSSPLEMTVWVPRLPLQIEVSDTELNQIKGWRVPIVSSRRPAGDSEEEEDDERRGRGCTLQYQHAMVRVLTQFVAEAAGPGGHLAHLLGSDWQVDITELINDFMQVEEPRIAKLQGGQILMGQELGMTTIQILSPLSDTILAEKTITVLDEKVTITDLGVQLVTGLSLSLQLSPGSNRAIFATAVAQELLQRPKQEAAISCWVQFSDGSVTPLDIYDGKDFSLMATSLDEKVVSIHQDPKFKWPIIAAETEGQGTLVKVEMVISESCQKSKRKSVLAVGTANIKVKFGQNDANPNTSDSRHTGAGVHMENNVSDRRPKKPSQEWGSQEGQYYGSSSMGLMEGRGTTTDRSILQKKKGQESLLDDNSHLQTIPSDLTSFPAQVDLPRSNGEMDGNDLMQASKGLSDLEIGMYALLGVFCLAILVFLINCVTFALKYRHKQVPFEEQEGMSHSHDWVGLSNRTELLENHINFASSQDEQITAIDRGMDFEESKYLLSTNSQKSINGQLFKPLGPIIIDGKDQKSEPPTSPTSKRKRVKFTTFTAVSSDDEYPTRNSIVMSSEDDIKWVCQDLDPGDCKELHNYMERLHENV
InterPro domains: - IPR031436: Transmembrane protein TMEM132, C-terminal (domain) [887-971]
- IPR031435: Transmembrane protein TMEM132, N-terminal (domain) [49-111]
- IPR055423: Transmembrane protein TMEM132, fifth domain (domain) [527-663]
- IPR055422: Transmembrane protein TMEM132, second Ig-like domain (domain) [128-266]
- IPR055421: Transmembrane protein TMEM132, cohesin-like domain (domain) [281-425]
- IPR026307: Transmembrane protein 132 (family) [23-1098]
- IPR031437: Transmembrane protein family 132, middle domain (domain) [427-524]
- IPR055424: Transmembrane protein TMEM132, sixth domain (domain) [664-779]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0022008 (neurogenesis), GO:0048882 (lateral line development), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0008544 (epidermis development), GO:0007423 (sensory organ development), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0030855 (epithelial cell differentiation), GO:0042490 (mechanoreceptor differentiation), GO:0048925 (lateral line system development), GO:0035315 (hair cell differentiation), GO:0035675 (neuromast hair cell development), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0048884 (neuromast development), GO:0048916 (posterior lateral line development), GO:0048881 (mechanosensory lateral line system development), GO:0048886 (neuromast hair cell differentiation), GO:0048919 (posterior lateral line neuromast development), GO:0048915 (posterior lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)