Protein: Replication factor A protein 2 (Q92373)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to single-stranded sequences
Subcellular location: Nucleus
Sequence: MAYDAFGKPGYGPDFNSAFSPGMGGGAGFNEYDQSSQPSVDRQQGAGNKLRPVTIKQILNASQVHADAEFKIDGVEVGQVTFVGVLRNIHAQTTNTTYQIEDGTGMIEVRHWEHIDALSELATDTYVRVYGNIKIFSGKIYIASQYIRTIKDHNEVHFHFLEAIAVHLHFTQKANAVNGANAPGYGTSNALGYNNISSNGAANSLEQKLAEYSLTPAQMTVMQAIHSAPETNEGVHVRQLAQSVGPGIDLTAVTDFLQQEGIIYTTIDENHFKSVLQDQ
InterPro domains: - IPR014646: Replication factor A protein 2 (family) [11-275]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [210-276]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [213-275]
- IPR014892: Replication protein A, C-terminal (domain) [167-270]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [44-172]
- IPR004365: OB-fold nucleic acid binding domain, AA-tRNA synthetase-type (domain) [80-147]
- IPR040260: Replication factor A protein-like (family) [44-272]
Interaction partners: - Replication factor A protein 1
- Replication factor A protein 3
- DNA polymerase delta catalytic subunit
- DNA primase small subunit
- Proliferating cell nuclear antigen
- DNA polymerase subunit delta-2
- DNA primase large subunit
- Protein kinase rad3
- Replication factor C subunit 4
- ATP-dependent DNA helicase pfh1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003697 (single-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0051716 (cellular response to stimulus), GO:1903046 (meiotic cell cycle process), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0007131 (reciprocal meiotic recombination), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0019438 (aromatic compound biosynthetic process), GO:0007127 (meiosis I), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0071897 (DNA biosynthetic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0048285 (organelle fission), GO:0000723 (telomere maintenance), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0006265 (DNA topological change), GO:0006260 (DNA replication), GO:0006261 (DNA-templated DNA replication), GO:0000722 (telomere maintenance via recombination), GO:0000725 (recombinational repair), GO:0000280 (nuclear division), GO:0006289 (nucleotide-excision repair), GO:0006278 (RNA-templated DNA biosynthetic process), GO:0071103 (DNA conformation change), GO:0032200 (telomere organization), GO:0006312 (mitotic recombination), GO:0035825 (homologous recombination), GO:0032446 (protein modification by small protein conjugation), GO:0010833 (telomere maintenance via telomere lengthening), GO:0006302 (double-strand break repair), GO:0007004 (telomere maintenance via telomerase), GO:0000724 (double-strand break repair via homologous recombination), GO:0140527 (reciprocal homologous recombination), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0005829 (cytosol), GO:0090734 (site of DNA damage), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005657 (replication fork), GO:0005662 (DNA replication factor A complex), GO:0043233 (organelle lumen), GO:0035861 (site of double-strand break), GO:0030894 (replisome), GO:0043601 (nuclear replisome), GO:0043229 (intracellular organelle), GO:0043596 (nuclear replication fork), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)