Protein: Vinculin (Metavinculin) (B3DI32)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004278}. Cell projection, podosome {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MPVFHTKTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTSPVAAVQAAVSNLVRVGKETVQTTEDKIMKRDMPSAFIKVENACAKLVEAAQMLRTDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLITYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVTSMNTVKELLPVLISAIKIFVTTKCTKSHGVEEALKNRNYTFDKMTAEINEIIRVLQLTSWDEDAWANKKDTEAMKRALALIESKMGQAKGWLRDPNALPGDPGEHALRQILDEAGKVGELCAGKERREILGTAKTLGQMTDQVSDVRARGQGATPMGMQKAQQVAQGLDILVGKVENAARKLEALTNAKQAIAKRIDNAQSWLADPNGGPEGEENIRALLAEAKRIADLCEDPKERDDILRSIGEIAGLTARLVELRRIGKGDTPEARALAKQIGTALQNLQAKTNRAVANMRPAKAAVTLEGKMEQALRWINNPGVDDHGVGQAAIRGLIAEGRRLASSLPGPYRQELLAKCEQVEQLMMQLADLAARGEGESPQARAVAAHLLEAIKDLKAKMQEAMTQEVSDVFSDTTTPIKLLAVAATAPLEAPNREEVFEERASNFENHASRLGATAEKAAAVGTANKSTVEGIQAAVKSARDLTPQVTSAARILLKNPGNQAAYEHFDTMKNQWIDNIEKMTSLVDEAIDTKSLLDASEEAIKKDIDKCRVAMANVQPQMLVAGATSIARRANRVLLVAKREVENSEDPKFRELVKAASDELGRTISPMVMAAKGVAGNIQDPGLQKGFLDSGYRILAAVGKVREAFQPQELDFPPPPPDLDQLHVNDDQAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEMVSEPMMVAARSLHDEARKWSSKPEVPDEGFEAAEAEVDIDDEDEFTDNEDDYEPELLLMSSNQPVNQPILAAAQSLHQEARKWSSKGNDIIGAAKRMALLMAEMSRLVRGGSGNKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISEEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
InterPro domains: - IPR017997: Vinculin (family) [1-1129]
- IPR000633: Vinculin, conserved site (conserved_site) [162-508]
- IPR006077: Vinculin/alpha-catenin (family) [371-1131]
- IPR036723: Alpha-catenin/vinculin-like superfamily (homologous_superfamily) [39-1126]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0007155 (cell adhesion), GO:0016043 (cellular component organization), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0098609 (cell-cell adhesion), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0090136 (epithelial cell-cell adhesion), GO:0034330 (cell junction organization), GO:0022607 (cellular component assembly), GO:0045216 (cell-cell junction organization), GO:0034329 (cell junction assembly), GO:0007043 (cell-cell junction assembly), GO:0034332 (adherens junction organization), GO:0034333 (adherens junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction)