Protein: ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) (P47857)
Organism: Mus musculus (Mouse)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:19889946}. Note=Principal piece region of the sperm flagellum. {ECO:0000269|PubMed:19889946}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:19889946}. Note=Principal piece region of the sperm flagellum. {ECO:0000269|PubMed:19889946}.
Sequence: MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV
InterPro domains: - IPR000023: Phosphofructokinase domain (domain) [18-686]
- IPR009161: ATP-dependent 6-phosphofructokinase, eukaryotic-type (family) [1-763]
- IPR022953: ATP-dependent 6-phosphofructokinase (family) [20-310]
- IPR041914: ATP-dependent 6-phosphofructokinase, vertebrate-type (family) [13-774]
- IPR015912: Phosphofructokinase, conserved site (conserved_site) [292-673]
- IPR035966: Phosphofructokinase superfamily (homologous_superfamily) [16-753]
Interaction partners: - Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase A
- ATP-dependent 6-phosphofructokinase, platelet type
- Fructose-bisphosphate aldolase B
- Hexokinase-2
- ATP-dependent 6-phosphofructokinase, liver type
- Hexokinase-1
- Fructose-bisphosphate aldolase C
- 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2
- Hexokinase-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0019200 (carbohydrate kinase activity), GO:0008443 (phosphofructokinase activity), GO:0003872 (6-phosphofructokinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0051051 (negative regulation of transport), GO:0042221 (response to chemical), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0019637 (organophosphate metabolic process), GO:0051224 (negative regulation of protein transport), GO:1901700 (response to oxygen-containing compound), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:1901135 (carbohydrate derivative metabolic process), GO:0051048 (negative regulation of secretion), GO:0046883 (regulation of hormone secretion), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010646 (regulation of cell communication), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:1903531 (negative regulation of secretion by cell), GO:0006002 (fructose 6-phosphate metabolic process), GO:0009743 (response to carbohydrate), GO:0006753 (nucleoside phosphate metabolic process), GO:0006757 (ATP generation from ADP), GO:0043436 (oxoacid metabolic process), GO:0070201 (regulation of establishment of protein localization), GO:0002792 (negative regulation of peptide secretion), GO:0050709 (negative regulation of protein secretion), GO:0006796 (phosphate-containing compound metabolic process), GO:0032880 (regulation of protein localization), GO:0072521 (purine-containing compound metabolic process), GO:0090278 (negative regulation of peptide hormone secretion), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0019693 (ribose phosphate metabolic process), GO:0051046 (regulation of secretion), GO:0016052 (carbohydrate catabolic process), GO:0050708 (regulation of protein secretion), GO:1904950 (negative regulation of establishment of protein localization), GO:0046676 (negative regulation of insulin secretion), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0050796 (regulation of insulin secretion), GO:0034284 (response to monosaccharide), GO:0016310 (phosphorylation), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0002791 (regulation of peptide secretion), GO:0006163 (purine nucleotide metabolic process), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0009746 (response to hexose), GO:0061615 (glycolytic process through fructose-6-phosphate), GO:0046031 (ADP metabolic process), GO:0006090 (pyruvate metabolic process), GO:0009749 (response to glucose), GO:0046034 (ATP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)