Protein: Non-structural protein V (P33483)
Organism: Mumps virus (strain SBL) (MuV)
Function: Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state (By similarity). Blocks the type I and II interferon signaling pathways by interacting with host STAT1, STAT2 and STAT3, and mediating their ubiquitination and subsequent proteasomal degradation (By similarity)
Subcellular location: Virion. Host cytoplasm
Sequence: MDQFIKQDETGDLIETGMNVANHFLSAPIQGTNSLSKASIIPGVAPVLIGNPEQKNIQHPTASHQGSKSKGSGSGVRSIIVPPSEAGNGGTQDPEPLFAQTGQGGIVTTVYQDPTIQPTGSSRSVELAKIGKERMINRFVEKPRISTPVTEFKRGAGSGCSRPDNPRGGHRREWSLSWVQGEVRVFEWCNPICSPITAAARFHSCKCGNCPAKCDQCERDYGPP
InterPro domains: - IPR024279: Paramyxovirinae protein V, zinc-binding domain (domain) [175-218]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0044068 (modulation by symbiont of host cellular process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0035821 (modulation of process of another organism), GO:0048523 (negative regulation of cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0052027 (modulation by symbiont of host signal transduction pathway), GO:0044501 (modulation of signal transduction in another organism), GO:0051701 (biological process involved in interaction with host), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0009966 (regulation of signal transduction), GO:0075136 (response to host), GO:0031348 (negative regulation of defense response), GO:0044414 (suppression of host defenses by symbiont), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0140418 (effector-mediated modulation of host process by symbiont), GO:0052029 (suppression by symbiont of host signal transduction pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:0052031 (modulation by symbiont of host defense response), GO:1902531 (regulation of intracellular signal transduction), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response), GO:0052562 (suppression by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0005576 (extracellular region), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)