wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: AP complex subunit sigma (Q78AM7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal
Subcellular location: Endomembrane system; Peripheral membrane protein
Sequence: MIKFLLMVNKQGQTRLSKYYEAVDLGKRAALEADVVRGCLARRKEECSFVEYKDYKLVYRQYAALFIVVGVTENENELSIYELVHNFVEVLDKYFSRVIMFNLDKVHIILDEMILNGHIVETNKNRILAPLLALDKMTES
InterPro domains: - IPR022775: AP complex, mu/sigma subunit (domain) [1-137]
- IPR016635: Adaptor protein complex, sigma subunit (family) [1-139]
- IPR011012: Longin-like domain superfamily (homologous_superfamily) [1-132]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048731 (system development), GO:0045229 (external encapsulating structure organization), GO:0043062 (extracellular structure organization), GO:0007399 (nervous system development), GO:0030198 (extracellular matrix organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: N-glycosylase/DNA lyase (A0A8N7V0N6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion
Subcellular location: Nucleus matrix. Nucleus speckle. Nucleus, nucleoplasm
Sequence: MSQHALLSASCKAWRSLSCPRSELRLDLTLGCGQTFRWRETADSHWTGVMRGKVWTLTQTEDTLWYYVYSHNNNPGPENRQKGKVEEEEQLLGKMSKRTTCIKQEDEGLCTVLSEPDKKEEELLRDYFQLDVKLGDLYKNWSTVDPHFKHTANIFTGVRLLRQDPVECLFSFICSSNNHISRIQGMVERLCQTLGTLLCKLDDVAYHDFPSLQDLTDPCVEMRLRDLGFGYRARFLQQSSQMIMNSHHPDWLQSLRSTPYLQARDALRTLPGVGLKVADCVCLMSLDKFEALPVDTHVWQIAKRDYNFAPGTSQKTLTDRVYKEIGDFYRKLWGPYAGWAQSVLFCADLKKFQKLKEEVLSEDKTELKIDERKRDRCAEKQKTQKKKSKRT
InterPro domains: - IPR052054: Oxidative DNA damage repair enzyme (family) [12-380]
- IPR003265: HhH-GPD domain (domain) [167-342]
- IPR011257: DNA glycosylase (homologous_superfamily) [164-348]
- IPR012904: 8-oxoguanine DNA glycosylase, N-terminal (domain) [17-169]
- IPR023170: Helix-hairpin-helix, base-excision DNA repair, C-terminal (homologous_superfamily) [136-349]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0140097 (catalytic activity, acting on DNA), GO:0003906 (DNA-(apurinic or apyrimidinic site) endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006310 (DNA recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: G protein-coupled receptor 185 b (F1QSZ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MIHSLAAAMSNQLQNTSSLSTAGTWNLLDVRNSSPVRTTELRPLPVSPWDIALCVTGTLISCENAIVIAILFYTPTLRAPMFILIGSLAFADLLAGLGLILNFVFIYMLNTEFVTLISVGMLIAAFSASVLNILAITVDRYLSLYNALTYHTERTVTFTYVVVVLIWLVCITLGLLPVLGWNCLRDEASCSICRPVTKNNAVVLAVTFLLVFALMMQLYLQICKIAFRHAQQIAVQHQFMAISTTKGVSTLSVILCTFAVCWMPFAMYSIVADSSYPMIYTYATVLPATCNSVINPIIYAYRNPDIQKSLWLACCGCVPSNFSLRPRTSSDV
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [63-299]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [48-311]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [63-311]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: 2',3'-cyclic-nucleotide 3'-phosphodiesterase (A0A8M3B0U8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Lipid- anchor
Sequence: MEAEQNQEVQEAVPETQEVAAQQEEKSEPKSEEAPQAPSEAAADPPAAATEPEKPQEREPSAEEQQKATESAAPPAKPSEPEAKSPEDSSEKTPEQQQKSSEEPSLQVNSEPEKQEEEAVKEAESKKEEPVKEADSKPAAVNEVKPEESEKSETTKAEGEKVQVPDSDGVQAEPPKEAEPEEKKPELPLFYGWFLLKEEEERIKCATMDFLKTLDTLEAFKEHISEFTSEANKEVDLEQYFQNPLPLHCTTKFCDYGKAEGAKEYAELQVVKEATGKSEELSVTALIVTPRTFGARVALTETQLNLWPEGEDKVGVAPTLLPGVESLPAGSRAHVTLGCSAGVEAVQTGLDLLEILVLQKEGKEGTQVEMDMGTLSYLSEGRWYLALREAITADTTFSSFSEDKPVSDQGKKDGEKKKKKCTIL
InterPro domains: - IPR047325: Cyclic nucleotide phosphodiesterase, catalytic domain (domain) [187-423]
- IPR008431: Cyclic nucleotide phosphodiesterase (family) [20-424]
- IPR009097: Cyclic phosphodiesterase (homologous_superfamily) [183-400]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004112 (cyclic-nucleotide phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RNA 3'-terminal phosphate cyclase-like protein (Q6DRI3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: As part of the small subunit (SSU) processome, it plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA. Activates BMS1 by promoting GDP/GTP exchange. Does not have cyclase activity
Subcellular location: Nucleus, nucleolus
Sequence: MEFEGCSGFRQRLVLSTLSGKPVKIRNIRSKDDNPGLRDFEASFIRMLDKLTNGTRIEINQTGTVLFYQPGLLYGGSVEHECNVQRSVGYYLEALLMLAPFMKTPIKAVLKGITNHPTDPSVDLLKVTAVPLMKRFGINGDGLEIKVVKRGMAPGGGGEVHFSCPVSRSMKPVQLTEAGKIKRIRGTAFSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGPNSGKSPGFGLVLVAETLNGVFLGAEVVSTPQGQGEMQLPEDLGRNCAKLLLEEIYRGGCVDSTNQSLALLYMTLGQQEVSKTLLGPLSPYTMDFLRHIRDFFQIMFKIETQKPSEDECKGGEKVLMTCVGAGYNNISKSIK
InterPro domains: - IPR036553: RNA 3'-terminal phosphate cyclase, insert domain superfamily (homologous_superfamily) [177-277]
- IPR037136: RNA 3'-terminal phosphate cyclase domain superfamily (homologous_superfamily) [3-337]
- IPR016443: RNA 3'-terminal phosphate cyclase type 2 (family) [1-366]
- IPR013791: RNA 3'-terminal phosphate cyclase, insert domain (domain) [176-280]
- IPR013792: RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (homologous_superfamily) [5-227]
- IPR020719: RNA 3'-terminal phosphate cyclase-like, conserved site (conserved_site) [150-160]
- IPR000228: RNA 3'-terminal phosphate cyclase (family) [2-359]
- IPR023797: RNA 3'-terminal phosphate cyclase domain (domain) [2-334]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Si:ch211-203l9.2 (A3KNM2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MEENDKGTQRPDFIQEVGEEAVDAAPCSPCTVLTEQEQAELHSELQKVEEEIQTLSQVLAAKEKQVAEIKRKLGITPLNELKQNLSKGWHDVTTSTAYKKTSETLSQVGQKATTAFSSVGTAITRKLEDVRNTPSFKSFEEKVETLKTKMSPKPSTSDIEEVSDSTPDGEPMIKQPDDTFSPDQQPH
InterPro domains: - IPR007327: Tumour protein D52 (family) [11-163]
Interaction partners: - Mal, T cell differentiation protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Translation initiation factor eIF2B subunit gamma (Q7ZTY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed
Subcellular location: Cytoplasm, cytosol
Sequence: MELQAVLMAAGGGSRMMDLTYNTPKPLLPVGNKPLIWYPLNLLERVGFEEVIVITTKEVQKALSTDQRLKTDVKMKLDVVCIQEEADMGTADALRHIQQKIKTDILVLSCDLITDVALHEVVDLFRAHNATLSMLMSKVHEFTETVPGQKGKKKAGEQRDFVGVDVTGKRLLFMANEADLEEGLVLRKSIMRKHPRMFIKTGLLDAHLYCLKRSVVDFLVHNKSVTSIRGELVPYLVRKQFSKSLNSQHVTEDSEKNQKQQEAHINMDLLSTSKDEALLQLARERSCWNDHRGDMSEAYHGGKIRCYVHIMEDGMCYRVNTLAAYIEANRVVPKLFEEPPIHPTAVVSERSLVGSDSIIGPSCQISDKTSIKRSNVGTSTVIKEKVKITNSIIMNGVTIEEGCNIQGSVICSHAVIGRGADIKYCLVGSGQRVDPEAERTNEVIVGSDQLMEI
InterPro domains: - IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [1-429]
- IPR051960: Eukaryotic Initiation Factor 2B Subunit Gamma (family) [1-447]
- IPR005835: Nucleotidyl transferase domain (domain) [5-141]
- IPR056764: EIF2B subunit epsilon/gamma, LbH domain (domain) [345-436]
Interaction partners: - Translation initiation factor eIF2B subunit delta
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 2 subunit 3
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 2 subunit 1
- Eukaryotic translation initiation factor 5
- U3 small nucleolar RNA-interacting protein 2
- GDP-mannose 4,6 dehydratase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Oxidation resistance protein 1 (A9JTH8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May be involved in protection from oxidative damage
Subcellular location: Mitochondrion
Sequence: MSFQRPKGTIEYSVESRDTLNNIALKFDTTPNELVQLNKLFSRNVVPGQVLYVPDPEYVSSAGSSPSFSPSSPLSPTSSEADLEKVTTDSNGPPRSDAPAPPVLSALRSSRVVSSTSEEEEALTEKFLKINCKYITDGKGVVSGVLLVTPNNIMFDPHRTDPLVLEKGCEEYGIMCPLEEVQSAAVYKEIIDSKIRDSVTDLEAVFSSFSHQTDQRYDSASTAPRSTEGSFSEDVFTESELSPIREEHQSTEELQQEDKSSGASSQSVQTLLQEPQSHTEEEDNDGEPAGDTAKPIQDEPTSRDHQQTPHCRDSETDVEELRKMCKTHTMQQAKEQRESVQQAQRESEQQTTEQSQRLSSAEGPVVSKERQKSHKFLCLRVGKAMKKTFVSNASASMQQYAQRDRKHEYWFAVPQERSDHLYVFFIQWSPDVFGDGLGSISRDPGFIVVKKIEESEANEEQQPEESSEKEWEVVSWTEYHRRIDALNSEDLRSLCKRLQITTKEDVNSKHGTSITASLEPETFKPNLNEPSDLLEAEQIEKLAKHLPPRTIGYPWNLAFSTSKHGMSIKTLYRAMQDQDSPMLLVIKDSDGQIFGALASEPFKVSEGFYGTGETFLFTFYPEFEAYKWTGDNLFFIKGDMDSLAFGGGSGEFGLWLDGDLYHGRNHSCKTFGNPMLSMKEDFFVQDIEIWSFE
InterPro domains: - IPR036779: LysM domain superfamily (homologous_superfamily) [3-63]
- IPR018392: LysM domain (domain) [10-54]
- IPR006571: TLDc domain (domain) [528-693]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0006979 (response to oxidative stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Serine protease (A0A8M1PSA1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MVPNWRLGLAHPCCIGLLFLLLLPSSVSVREPRHQSHVHRTLLKPHATLPLSRSRFSAKTQLDFTTHCNESCYHKAEDQDKEHLAFETLYADGSRTLTTVDLDEVDVDPPPRQLTSRHKRLKRQIYGADGRFNIRGDHFLLDYPFSTAVRISTGCTGVLVSQQHVLTAAHCVHDGKDYVKGAKKLRVGFLIPPSVNGTRSGQAPVKKPLVRWVRVKRTRVPKGWIQGPQEVSMDFDYALLELRWPHRRPFMRLAVAPTSDHLAGKRIHFSGFDSDRPGELVYRFCPVEDESNDLIYQHCDARPGASGSGVYGRVWDDILERWERKVIGIFSGHQWLEINGENRDYNVAVRFTPLKFAQICYWVHGNKVDCSQD
InterPro domains: - IPR008256: Peptidase S1B (family) [155-311]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [124-355]
- IPR050966: Glutamyl Endopeptidase (family) [17-370]
- IPR001254: Serine proteases, trypsin domain (domain) [143-275]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [166-171]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [126-329]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0071466 (cellular response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Mitofusin-2 (A0A8M2BJP0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein
Sequence: MSLVFPRPNTSVIGKKDKRLMAEVNASPLKHFVTAKKKINGIFEQLGAYIKESSAFLEETYSNEELDPVTTEEQVAEVRGYLSKVAGIGEVLSRRHMKVVFFGRTSNGKSSVINAMLWDKVLPSGIGHTTNCFLRVEGTDGNESFLLTEGSDERKSVKTVNQLAHALHQDEDLDAGSLVCVMWPKAKCALLRDDLVLVDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKSFFHKVNERLSSPNIFILNNRWDASANEPEYMEEVRRQHMDRCTSFLVDELRVVDRSHAGDRIFFVSAKEVLQARVQKAQGMPEAGGALAEGFQARMFEFQNFERRFEECISQSAVKTKFEQHTTRAKQISEALRLIMDSVHIAAQEQRIHCLEMKEEREDRLEFIDKQLDLLTLDCKSKIKKITEEVEKQVSNAMAEEIRRLAVLVDDFHMDFHPSPVVLKVYKNELHRHIEEGLGRNMSERCSSAITVALQTTQTDMIDGLKPLLPITIREQVDKMVPRQCFALSYDLNCDKLCSDFQEDIGFHFSLGWTMLVNRFLGPKNTRRALMGYNDQVPRSLAITPVSTSMPPFPQGSMTQEELMVSMVTGLASLTSRTSMGIIVVGGVIWKAVGWRLIALSVGLYGLLYVYERLTWTTRAKERTFKRQFVDYASEKLQLIVSYTGSNCSHQVQQELASTFSQLCQQVDVTRQQLEDEIGDLNSKIEQLDTLQSKAKLLRNKAGWLDSELNMFIQQYLQQGR
InterPro domains: - IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [78-360]
- IPR030381: Dynamin-type guanine nucleotide-binding (G) domain (domain) [93-342]
- IPR045063: Dynamin, N-terminal (domain) [99-258]
- IPR006884: Fzo/mitofusin HR2 domain (domain) [594-754]
- IPR027094: Mitofusin family (family) [25-741]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0035845 (photoreceptor cell outer segment organization), GO:0007399 (nervous system development), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0007005 (mitochondrion organization), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0048284 (organelle fusion), GO:0008053 (mitochondrial fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)