Protein: Stage IV sporulation protein FA (P26936)
Organism: Bacillus subtilis (strain 168)
Function: Implicated in the coupling of mother cell to forespore gene expression. Required for spore formation at 37 degrees Celsius, but not at 30 degrees Celsius. SpoIVFA plays a central role in both maintaining the SpoIVFA/BofA/SpoIVFB complex and anchoring it to the outer forespore membrane. SpoIVFA brings BofA into close proximity to SpoIVFB, allowing BofA to inhibit SpoIVFB. Increased accumulation of SpoIVFA seems to inhibit the activity of SpoIVFB and thus regulates the activation of sigma-K.
Subcellular location: Forespore outer membrane.
Sequence: MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTDQEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIKPAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQDFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVDVALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE
InterPro domains: - IPR011055: Duplicated hybrid motif (homologous_superfamily) [130-262]
- IPR016047: M23ase, beta-sheet core domain (domain) [167-257]
Interaction partners: - Stage IV sporulation protein FB
- Sigma-K factor-processing regulatory protein BofA
- SpoIVB peptidase
- Carboxy-terminal processing protease CtpB
- Stage II sporulation protein M
- Stage II sporulation protein P
- Stage II sporulation protein Q
- Stage III sporulation protein AH
- Stage II sporulation protein D
- Stage III sporulation protein AG
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0071554 (cell wall organization or biogenesis), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0044036 (cell wall macromolecule metabolic process), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006037 (cell wall chitin metabolic process), GO:0042546 (cell wall biogenesis), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0009273 (peptidoglycan-based cell wall biogenesis), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0044038 (cell wall macromolecule biosynthetic process), GO:0070589 (cellular component macromolecule biosynthetic process), GO:0006022 (aminoglycan metabolic process), GO:0030203 (glycosaminoglycan metabolic process), GO:0006023 (aminoglycan biosynthetic process), GO:0009252 (peptidoglycan biosynthetic process), GO:0006024 (glycosaminoglycan biosynthetic process), GO:0000270 (peptidoglycan metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009295 (nucleoid), GO:0043229 (intracellular organelle), GO:0043590 (bacterial nucleoid), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle)