Protein: Intermembrane lipid transfer protein VPS13 (Vacuolar protein sorting-associated protein 13) (G0S3B8)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Function: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phospholipids, including phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), and phosphatidylserine (PS). May play a role in mitochondrial lipid homeostasis, Golgi vesicle transport, reticulophagy, actin cytoskeleton organization and formation of the prospore membrane (By similarity).
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Sequence: MLEGLVAGLLNRFLGMYVKNFDPKQLKWEVWNGKVRLDNLELQREALDQLKLPINVIKGHLGHLVLHIPWKTLASEQVKINIEDVFLLASPKEEAEYDEDEEARRRHRLKMEKLDSAELLKERSQEGLSEEEQKRTQTFAQALVTKIVDNLQITIRNIHIRYEDAISAPGHPFALGITLEEFSAVSTDSDWTPAFITSIQSAHKLATLESLAIYWDTDAKLIGPGREPHEHSDQIPHDEMLKFFREMIAKGEADLSSEHQFILKPVSGQAKIEIDKTGSHTVPRYKANLLFDEIGVVLDDQQYRDALMMVDLFHYFIRHQEYKKFQPKGVTPKEDPRAWFRFAGNAVLSKIHERNRRWSWDYFRERRDDRRRYIELFKKTKQNIQLTPEEREDLDKLEWKLSYEDLRFWRSLARNQLKKENAEALKNKPPPQPQQQQGWLSWVWGSKPVQPQQEEQQGDENTRITEAQRKELYEVIQWDEKAALAAEIDVPRDSVRLLIETSLSTGSFTLRQNPHGDARDLISLHFDLFRAKGLTRPDSFLIDISLGGFRVNDNTTPDSLYKEIVRVKDAPNTEGQKRYSIADLELTVDEEAFFELQVEQHPLDGQGDVAVTMKLKPLEIIWNPNVVVGIADFFRPPERHMESINALLETANATVEGLRAQTRAGLQFALEEHKTVNAKLDLQAPLIILPESITTPNSTCLIVDAGHISVNSELVDKETMKQVQSTQDRPCTEEDLRRLEELMYDRFLVKLTSTQVLIGPSVEITKQQLVQRDEKRQLHIVDQINLDFVVAMSILPKAPNLTKLKISGHLPVLQVNASDSKYKHLMRIIEVAIPKLYDVEPVLAPSGSHPTIRPRLASDASTRSRRASFRKASTQFLQFVSQQQEIVLDESDSDDDSEKFEDAKDTSVDEQLRIQQRIFDFKFTVDQLRGSLYRSDPEGKHPDQLLVELVAENFGVEYHLRPYDMSAMVSLGSVTMDDFVENPPAEFKSIVSSGDIEDRKQARDLVRVKFVRVKKESPEFMSVYDGIETNVDVAISTINLVVTRKTLLTLLDFILVTFSNPQPAAPVATRMAVTDQESETNIIVQPPPIESGPIRVKVDLKSIRMILNNDGIRLATLSFNHADVGVYILGRYMRVSAKLGDLSLVDDVNLGVSEDSSLRQLVTIQGNELADFRYEYFDPDKPEKNPGYDSSIYLRAGSVKVNFIEEPFRKIVDFLVKFGKMQAIYNAARMAAANQAQQLQQSQSRIKFDIVVKTPIVVFPRVVMSPKPKRDVITAYLGEIYAQNAFVPLDDSEKADMAMKLTTGIRNIRLTSHFHYSEGRDEVLELIDHVDLGFTIIYAEHKEGIKRPDLEIEGSMSDFNLRITPYQLSALLAISQSVPTVFAADVEQHTADAERDVDVATLERARTMPSYSGASEEKVIDMAPELGTHGEAWTKLDLVFTVNTIGLELINAEEDYPVGDLEAASLSRFSLNSSRLKTRMDSNGSLEAEFVIQAFTIYDTRHRETNKFRRIMTSGNSNVDQLMASITMTGGKDRNIIAMVAIDSPRFIFALDYLFAIQKFITIGTTLPEAPIPEKSPMETPEETSDADSVRVGSSGRHSESSAGSGQQLVPVGSQQQQPVLAASEQATTSIAFRVNIVDAQVILIANPLSSSSEAMVLGTKQVVLSQQHSLTFQISECGMFLCRMDRFDDSRLRIIDDFSVKVAVDMSKPNITQVHADIEPLILRLSLRDILLVMQTIAKASELSGGTPSETASKTVAERKAQQLRAAGLKHRTASGKGTSTLATRTRHASQSAASHSGKTTTLVMQEVAKQTQRFEELILTVEGTRMVLLGDVHELPIIDMSVKTFTIHAENWTSNLKAETAFDMYMNVYNFAKSAWEPLIEPWQVGFGITREAKTGVLSVDVTSKKTFDVTITAATIALLSQSFAFFSKEQDVLTKPRGVEAPYRIRNYTGFDVIISTKRQIPGASPTTEQQLPTMTLRLEDGQEAPWSFEEWEKMRESLMTESSTANSISVQLVGSGFQEVKSIRLTREGEFLFGLKPKTQQVLHKLLVEIKLGKDNIKYVTLRSPLLVENDTGIVVELGVYDAHEGHLLKIERINPGESKPAPVGAAYFKSLLVRPDPGFKYGWSSDTLWWRDLLKRPTKTLVCKSEQYGGEVFYFRLHARWDQANPLTRNYPYMRLKLTAPLTIENLLPYDFKYKIYDRVNKQEWNNFLRKGGSIPVHMVDLSHTFLLGIEMQDTPFQASEFVVINTGNADDFKKDSHLVVKDNAGMPLNLRLHYFRIPDGGGSFKVTVYSPYVILNKTGLDVSVRSKGFMQSARAAAGQTLIDVGGDGQKKARPLMFSFHNDDHRNRALLKAGDSEWSKPQSFDAIGSTTEVVLQTANRNAEIHLGVTVDSGQGKYKMVKVVTLAPRYVIHNKLGEDINIREPSSSFWIPLKHGAHRPLHWLQRGAVKQLCLCYPGVDNQWTAPFNISDLGITHLKIARAGQRQRLIRVEILMEDATIFLNLSMEQRNWPFSMRNESDTEFTFYQVNPTIEEDASEDRSGWRPVRYRLPPRSIMPYAWDFPAAKHKEICICAYNKERHVKLQEIGNLMPMKLALPNGESKTIDINVTADGPTQTLILSNYRQSKSLYRQRSNAGSISGREGFEAKEFDTGTTFRATLRLSGIGVSIINTQLKELAYITLRDVQLRYSDSALYQTFSLAVKWIQIDNQLYGGIFPMILYPSVVPKRAQEIDAHPSLHAMVTRVKDESYGVEYIKYATVLLQEMTVELDEDFIYAVLEFSKIPGASWESTQEEDRLCDDSVDVPQPKQQQAGRDIYFEVLNIQPMQLDLSFVRTERVNVEDKTSSRNPVMFFFNVMTMAIGNINDAPVRFNALMLENVRVSIPVLIQNISNHYSQEALYQIHKILGSADFLGNPVGLFNNISSGFADIFYEPYQGLIMSDRPEDFGLGLARGAGSFFKKSVYGFTDSFSKVTGSFAKGLAAATMDKQFQDRRRITRARNRPKHALFGVTAGANSLISSVASGVGGLARKPLEGAEQEGALGFFKGIGKGVVGLATKPAIGVLDFASNISEGVRNTTTVFSSSEASELDRVRLPRHIAADGIVRPYSQREALGQSWLKQVDNGKYFDEAYIGHLELPTEDMVVMVTYARILLIRSRRLQTEWDVPLKDVQTIAKERTGLSLTLRGGTNGPFIPVAQESGRAFLYRMVAVAVEEFNRRFRGLE
InterPro domains: - IPR026847: Vacuolar protein sorting-associated protein 13 (family) [1-3176]
- IPR026854: Vacuolar protein sorting-associated protein 13, N-terminal domain (domain) [1-906]
- IPR056747: VPS13-like, middle region (domain) [1182-1918]
- IPR017148: Vacuolar protein sorting-associated protein 13, fungi (family) [1-3225]
- IPR009543: Vacuolar protein sorting-associated protein 13, VPS13 adaptor binding domain (domain) [1994-2570]
- IPR056748: Intermembrane lipid transfer protein VPS13-like, C-terminal (domain) [3094-3199]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)