Protein: RNA-binding protein 24 (Q76LC6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre- mRNA alternative splicing events of several pluripotency and/or differentiation genes. Plays a role in the regulation of mRNA stability and mRNA translation to which it is bound. Involved in myogenic differentiation by regulating myog levels. Binds to a huge amount of mRNAs (By similarity). Required for embryonic heart development, sarcomer and M-band formation in striated muscles
Subcellular location: Nucleus. Cytoplasm
Sequence: MHTTQKDTTYTKIFVGGLPYHTTDSSLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMADRSAADRACKDPNPIIDGRKANVNLAYLGAKPRVMQPGFTFGVPQIHPAFIQRPYGIPTHYVYPQAFMQPSVVIPHIQPTATSATASSPYIDYTGAAYAQYASAATAAAAAAYEQYPYAASPAATGYVAAAGYGYAMQQPLATAAPGSAAAAAAAFGQYQPQQLQAERMQ
InterPro domains: - IPR000504: RNA recognition motif domain (domain) [11-88]
- IPR050886: RNA-binding_regulatory_proteins (family) [5-203]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [6-92]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [2-93]
Interaction partners: - RNA binding protein fox-1 homolog 1
- RNA binding protein fox-1 homolog 1-like
- Coronin
- Small muscular protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051094 (positive regulation of developmental process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0048729 (tissue morphogenesis), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0051130 (positive regulation of cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0032970 (regulation of actin filament-based process), GO:0043170 (macromolecule metabolic process), GO:0035295 (tube development), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0006139 (nucleobase-containing compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0051128 (regulation of cellular component organization), GO:1904888 (cranial skeletal system development), GO:0035239 (tube morphogenesis), GO:0035282 (segmentation), GO:0048705 (skeletal system morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0048702 (embryonic neurocranium morphogenesis), GO:0048562 (embryonic organ morphogenesis), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0032956 (regulation of actin cytoskeleton organization), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0061053 (somite development), GO:0051147 (regulation of muscle cell differentiation), GO:0051149 (positive regulation of muscle cell differentiation), GO:0009855 (determination of bilateral symmetry), GO:1902903 (regulation of supramolecular fiber organization), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0001501 (skeletal system development), GO:0090304 (nucleic acid metabolic process), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0060537 (muscle tissue development), GO:0033043 (regulation of organelle organization), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0010638 (positive regulation of organelle organization), GO:0010467 (gene expression), GO:0009952 (anterior/posterior pattern specification), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0060297 (regulation of sarcomere organization), GO:0043009 (chordate embryonic development), GO:0007368 (determination of left/right symmetry), GO:0016070 (RNA metabolic process), GO:0051493 (regulation of cytoskeleton organization), GO:0014706 (striated muscle tissue development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048738 (cardiac muscle tissue development), GO:0060538 (skeletal muscle organ development), GO:0051153 (regulation of striated muscle cell differentiation), GO:0060298 (positive regulation of sarcomere organization), GO:0006396 (RNA processing), GO:0051155 (positive regulation of striated muscle cell differentiation), GO:0048706 (embryonic skeletal system development), GO:0001947 (heart looping), GO:0007519 (skeletal muscle tissue development), GO:0110020 (regulation of actomyosin structure organization), GO:0051495 (positive regulation of cytoskeleton organization), GO:0003228 (atrial cardiac muscle tissue development), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)