Protein: Arginine and glutamate-rich protein 1 (Q9VL63)
Organism: Drosophila melanogaster (Fruit fly)
Function: Post-transcriptional regulator of gene expression; modulates splicing and premature cleavage at cryptic polyadenylation sites of its own pre-mRNA through binding and regulation of the U1-snRNP complex
Subcellular location: Nucleus. Nucleus speckle. Note=Phase separation and localization to nuclear speckle-like structures is enhanced by binding to sisRNA
Sequence: MGSRSRTPSPSGKRRHHKSKHKKRSKSHHDHERPSTRTDRDKSSEVNNHGRHRERDRDRERDRHRSDRHTERDYRHSPSILKSRKRSSSSSSDSQYSEQESQRSKQKRSRFKKLDEQNQMQVERLAEMERQRRAKELEQKTIEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVETAKAEMEREMMLELERRREQIREEERRREEDEKQKREELEEILAENNRKIEEAQRKLAEERLAIIEEQRLMDEERQRMRKEQEKRVKEEQKVILGKNNSRPKLSFSLKPGAL
InterPro domains: - IPR033371: Arginine and glutamate-rich protein 1 (family) [3-286]
Interaction partners: - U1 small nuclear ribonucleoprotein 70 kDa
- Uncharacterized protein, isoform B
- non-specific serine/threonine protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0007283 (spermatogenesis), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0007292 (female gamete generation), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0048477 (oogenesis), GO:0090596 (sensory organ morphogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0030182 (neuron differentiation), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0042461 (photoreceptor cell development), GO:0001654 (eye development), GO:0098916 (anterograde trans-synaptic signaling), GO:0048699 (generation of neurons), GO:0065003 (protein-containing complex assembly), GO:0046530 (photoreceptor cell differentiation), GO:0150063 (visual system development), GO:0046785 (microtubule polymerization), GO:0048749 (compound eye development), GO:0001745 (compound eye morphogenesis), GO:0140694 (non-membrane-bounded organelle assembly), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development), GO:0042051 (compound eye photoreceptor development), GO:0001751 (compound eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)