Protein: Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) (P42773)
Organism: Homo sapiens (Human)
Function: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Sequence: MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [1-168]
- IPR002110: Ankyrin repeat (repeat) [11-167]
- IPR050776: Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor (family) [7-159]
Interaction partners: - Cyclin-dependent kinase 6
- Cyclin-dependent kinase 4
- G1/S-specific cyclin-D3
- G1/S-specific cyclin-D1
- G1/S-specific cyclin-D2
- Cellular tumor antigen p53
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase inhibitor 1
- Cyclin-dependent kinase inhibitor 1C
- Cyclin-L2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030291 (protein serine/threonine kinase inhibitor activity), GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity), GO:0004861 (cyclin-dependent protein serine/threonine kinase inhibitor activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051726 (regulation of cell cycle), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0072089 (stem cell proliferation), GO:0008285 (negative regulation of cell population proliferation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0045786 (negative regulation of cell cycle), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0072091 (regulation of stem cell proliferation), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051338 (regulation of transferase activity), GO:0051174 (regulation of phosphorus metabolic process), GO:2000647 (negative regulation of stem cell proliferation), GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:1904030 (negative regulation of cyclin-dependent protein kinase activity), GO:0031400 (negative regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)