Protein: Chaperonin GroEL 1 (EC 5.6.1.7) (60 kDa chaperonin 1) (Chaperonin-60 1) (Cpn60 1) (P9WPE9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Prevents aggregation of substrate proteins and promotes their refolding. In vitro, activity may be independent of the presence or absence of the GroES co-chaperonin or ATP. Shows weak ATPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00600}.
Sequence: MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [136-408]
- IPR018370: Chaperonin Cpn60, conserved site (conserved_site) [403-414]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [183-374]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [22-525]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [5-522]
- IPR001844: Chaperonin Cpn60/GroEL (family) [1-537]
Interaction partners: - Co-chaperonin GroES
- Chaperone protein DnaK
- Chaperonin GroEL 2
- Protein GrpE
- Chaperone protein DnaJ 1
- Possible formate hydrogenase HycE
- Chaperone protein HtpG
- Chaperone protein DnaJ 2
- Heat-inducible transcription repressor HrcA
- Conserved hypothetical proline rich protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009628 (response to abiotic stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0006457 (protein folding), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0051701 (biological process involved in interaction with host), GO:0001666 (response to hypoxia), GO:0044093 (positive regulation of molecular function), GO:0051098 (regulation of binding), GO:0042026 (protein refolding), GO:0070482 (response to oxygen levels), GO:0051099 (positive regulation of binding), GO:0051101 (regulation of DNA binding), GO:0044406 (adhesion of symbiont to host), GO:0036293 (response to decreased oxygen levels), GO:2000677 (regulation of transcription regulatory region DNA binding), GO:0043388 (positive regulation of DNA binding), GO:2000679 (positive regulation of transcription regulatory region DNA binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)