Protein: Pleiotrophin (PTN) (Q502U6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU369117}.
Sequence: MQQQWVCVALLALLTVTATLADGGKTEKQGKKERKSDCGEWQWSVCVANEGDCGLGTREGTRSGNDCKQTIKTQRCKIPCNWKKQFGGECKYDFQAWGECDSTTGMKTRTGVLKRALMDANCPNTVSATKPCGKPKTKMQDSQKPKRDGKKKERNPTD
InterPro domains: - IPR020090: Pleiotrophin/Midkine, C-terminal domain (domain) [87-150]
- IPR020091: Pleiotrophin/Midkine disulphide-rich domain superfamily (homologous_superfamily) [25-132]
- IPR000762: Midkine heparin-binding growth factor (family) [5-153]
- IPR037122: Pleiotrophin/Midkine, N-terminal domain superfamily (homologous_superfamily) [24-87]
- IPR020089: Pleiotrophin/Midkine, N-terminal domain (domain) [25-86]
- IPR038130: Pleiotrophin/Midkine, C-terminal domain superfamily (homologous_superfamily) [90-132]
Interaction partners: - ALK tyrosine kinase receptor
- Protein tyrosine phosphatase receptor type Z1a.
- Protein tyrosine phosphatase receptor type Z1b.
- Tyrosine-protein kinase receptor
- Syndecan
- Midkine
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0008201 (heparin binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0040012 (regulation of locomotion), GO:0035295 (tube development), GO:0010632 (regulation of epithelial cell migration), GO:2000145 (regulation of cell motility), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0007420 (brain development), GO:0035282 (segmentation), GO:0051216 (cartilage development), GO:0010594 (regulation of endothelial cell migration), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0021915 (neural tube development), GO:0061448 (connective tissue development), GO:0072359 (circulatory system development), GO:0048732 (gland development), GO:0007417 (central nervous system development), GO:0060485 (mesenchyme development), GO:0030334 (regulation of cell migration), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0009952 (anterior/posterior pattern specification), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)