Protein: RING-type E3 ubiquitin transferase (E9PBG3)
Organism: Homo sapiens (Human)
Subcellular location: Cytoplasmic vesicle, secretory vesicle
Sequence: MCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
InterPro domains: - IPR050617: E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins (family) [1-564]
- IPR003879: Butyrophylin-like, SPRY domain (domain) [401-526]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [353-554]
- IPR000315: B-box-type zinc finger (domain) [52-94]
- IPR047065: E3 ubiquitin-protein ligase Trim36, B-box-type 2 zinc finger (domain) [55-99]
- IPR040859: Midline-1, COS domain (domain) [204-252]
- IPR001870: B30.2/SPRY domain (domain) [340-565]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [371-559]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [276-356]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [265-354]
- IPR017903: COS domain (domain) [201-258]
- IPR003961: Fibronectin type III (domain) [264-355]
- IPR035727: TRIM36, PRY/SPRY domain (domain) [360-563]
- IPR047066: E3 ubiquitin-protein ligase Trim36, B-box-type 1 zinc finger (domain) [1-50]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0042802 (identical protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003723 (RNA binding), GO:0015631 (tubulin binding), GO:0043014 (alpha-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0045926 (negative regulation of growth), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0045786 (negative regulation of cell cycle), GO:0051129 (negative regulation of cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0046605 (regulation of centrosome cycle), GO:0010826 (negative regulation of centrosome duplication), GO:0010824 (regulation of centrosome duplication), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)