Protein: Defensin beta 136 (Beta-defensin 136) (DEFB137) (Q30KP8)
Organism: Homo sapiens (Human)
Function: Host defense peptide that exhibits antibacterial and antifungal activity. Exhibits antimicrobial activity against E.coli, S.aureus and C.albicans (in vitro). Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be involved in immunoregulation through LPS neutralization.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P60022}.
Sequence: MNLCLSALLFFLVILLPSGKGMFGNDGVKVRTCTSQKAVCFFGCPPGYRWIAFCHNILSCCKNMTRFQPPQAKDPWVH
InterPro domains: - IPR035307: Beta-defensin 136/42 (family) [1-75]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0009607 (response to biotic stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:2000145 (regulation of cell motility), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002685 (regulation of leukocyte migration), GO:0050920 (regulation of chemotaxis), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:1901700 (response to oxygen-containing compound), GO:0001817 (regulation of cytokine production), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0045087 (innate immune response), GO:0002687 (positive regulation of leukocyte migration), GO:0098542 (defense response to other organism), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0070887 (cellular response to chemical stimulus), GO:0002697 (regulation of immune effector process), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0001819 (positive regulation of cytokine production), GO:0002699 (positive regulation of immune effector process), GO:0050921 (positive regulation of chemotaxis), GO:0019730 (antimicrobial humoral response), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032642 (regulation of chemokine production), GO:0032722 (positive regulation of chemokine production), GO:0002718 (regulation of cytokine production involved in immune response), GO:0002237 (response to molecule of bacterial origin), GO:0010628 (positive regulation of gene expression), GO:0030334 (regulation of cell migration), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0010468 (regulation of gene expression), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:0002688 (regulation of leukocyte chemotaxis), GO:0071675 (regulation of mononuclear cell migration), GO:1901701 (cellular response to oxygen-containing compound), GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide), GO:0090026 (positive regulation of monocyte chemotaxis), GO:0090025 (regulation of monocyte chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)