Protein: Guanine nucleotide-binding protein subunit alpha (Q00743)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sequence: MGCGMSTEDKEGKARNEEIENQLKRDKMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDERESFKEIIYSNTVQSMRVILEAMESLELPLEDARNEYHVQTVFMQPAQIEGDSLPSEVGNAIAALWQDAGVQECFKRSREYQLNDSAKYYFDSIERIAQSDYLPTDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDRFKEKLPVSPMKNYFPDYEGGADYAAACDYILNRFVSLNQAEQKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRLCGLI
InterPro domains: - IPR011025: G protein alpha subunit, helical insertion (homologous_superfamily) [61-181]
- IPR002975: Fungal G-protein, alpha subunit (family) [59-339]
- IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit (family) [10-353]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [30-350]
Interaction partners: - G-protein beta subunit
- Developmental regulator flbA
- Adenylate cyclase
- Guanine nucleotide-binding protein subunit gamma
- Guanine nucleotide-binding protein alpha-3 subunit
- cAMP-dependent protein kinase
- DUF7582 domain-containing protein
- Protein fluG
- Regulator of G protein signaling domain protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:1903665 (negative regulation of asexual reproduction), GO:0019954 (asexual reproduction), GO:0043934 (sporulation), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:1903664 (regulation of asexual reproduction), GO:0071704 (organic substance metabolic process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0009847 (spore germination), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0045596 (negative regulation of cell differentiation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0044248 (cellular catabolic process), GO:0043937 (regulation of sporulation), GO:0045595 (regulation of cell differentiation), GO:0034305 (regulation of asexual sporulation), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0030436 (asexual sporulation), GO:0043939 (negative regulation of sporulation), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0048315 (conidium formation), GO:0061794 (conidium development), GO:0005984 (disaccharide metabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0060284 (regulation of cell development), GO:0075306 (regulation of conidium formation), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0016052 (carbohydrate catabolic process), GO:0010721 (negative regulation of cell development), GO:0005991 (trehalose metabolic process), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0009313 (oligosaccharide catabolic process), GO:0046352 (disaccharide catabolic process), GO:0005993 (trehalose catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0001750 (photoreceptor outer segment), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane), GO:0005929 (cilium), GO:0098588 (bounding membrane of organelle), GO:0043005 (neuron projection), GO:0060170 (ciliary membrane), GO:0097733 (photoreceptor cell cilium), GO:0097730 (non-motile cilium), GO:0097731 (9+0 non-motile cilium)