Protein: IQ domain-containing protein N (A0A1D5RMD1)
Organism: Mus musculus (Mouse)
Function: Essential for spermiogenesis and fertilization. May be required for manchette assembly in elongating spermatids
Sequence: MAAMQPAAQLQFQNLMSPSGPSLPQPTPIHQEKVAKLCPQLQHDFYPSEELAVLPSQEVPRLRAVVESQAFRNILVDEMDMMVSRAATVIQASWKGYRLRQKLISQMTAAKAIQEAWRRFSTRRLMHSNRLTVKKAKREDEEDIPYHQPQQVRFHAPEDQPPVMVTKETQFPSFDNLVPSQATAGPCASRVPGGGLHPQYVINRLTVPKYQPCMLTKTFRSSCLMRHLEGDSLKIRHVASKTIKVGALEAAATGRYGQAMHGSLKTQTQAHTESDVPKAPLRIYPVNKTHTKVCPMAAAVPESSATMSTAPRSAPQARPTSPATVMKMQATTSPTSPVIRLPAPVGPNSSLSNTTPQMQVRYMMPGARIQPPGSAVASTIKALPHFGAPVMKVPLQTGPGFTMTKTSLQMRPMTRSQAQTYTVSTSSKTSPSSPTVKPSPQTRLAAMLTKTPAQLRSVAAVFRTLCGGTTEAVASSPRCSPQSPVVAGNTPSQVHLNSTRTKVTVSTKQATTVVKVNSQSYLGRCGSQGNLDTIVPKPPATYPLEVEKMKSCPARSPKKEAALKTNTTIAARALSWTKMMEDRSKALTQIKQRAEIIKVHFRVYMPEEIPVTLTQAQLAVPLTKSSSQIQPPPCHARTQPTSPFCKAVSQSCMPSGLAHGTPEGQRPPVGLSASLSSSPLAAHLMSLTAQLQPACEQARSVSRDHLTRSCPASASLQARSSGTIVPPEVYPNTYSPTSAPQHHMASLLAKSSSQLHPPAEHAKTMNTKTTKAACQVCPSTKLSKAPSLAQLITCLAKVPSQAQLATETAKCLLAAHPTTDHRSKTQSQTFLSSSKASVQLWQHLGTLSTGSRAKPDDRSVAQPQLHSHAPNKTMQNPRSVVTDSQGMLIPLMTPSGHPVCNAESWGDSGRAQTPPPSPVPNQAVPCHDDLAASVASLCADLVAMLGSPEDLRTLLVKTLSQGEVRTALSQALSREVLGPSVVKALPQGMLGMALMKALSWGELGISLSRALSRGELRPELNKATQGKLAEVLCKALTEEERATLSQALCQGELGAVFTQSLAQMAQRTGTFLPKATSKTVGSRMTTAPAPVEVTCSGSLSVAWGPAMGPVGARCSKGPVDAGLASGQSWNSKVPNVSVRATAHAGAPQGVWYPSRGHKPWDPIGAEAELDRKPSAELLMSVQGMEKVVVQAVVTIQACARGYLVRRTVKVWHQWATIIQATWRGYRVRRNLERLFRATTIIQAAWRGYCIRRARARQVLLPIAWPEHSGRTKGTLDNRNSSEHRCFLSCQPDVCSVCQSLGPPVESPPSVVMLVGSQPRTCHVCGHTLSTRVVQGFGQGISGQPVSRWASASQQNTLLSQQHRACTIIQAAWKGYRTRRQLSQKQSAAKMVQAVWRGHYTRSCLTTDALLGTGGPWSISRDTSRHSSRAYSLHWPGV
InterPro domains: - IPR052318: Cell Division and Developmental Signaling Domain-Containing Protein (family) [341-1113]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [69-1254]
- IPR000048: IQ motif, EF-hand binding site (binding_site) [82-1405]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:2000243 (positive regulation of reproductive process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:2000241 (regulation of reproductive process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048515 (spermatid differentiation), GO:0060046 (regulation of acrosome reaction), GO:0032886 (regulation of microtubule-based process), GO:0048240 (sperm capacitation), GO:1901317 (regulation of flagellated sperm motility), GO:2000147 (positive regulation of cell motility), GO:0007283 (spermatogenesis), GO:0071695 (anatomical structure maturation), GO:1902019 (regulation of cilium-dependent cell motility), GO:2000155 (positive regulation of cilium-dependent cell motility), GO:0060632 (regulation of microtubule-based movement), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0003352 (regulation of cilium movement), GO:0060295 (regulation of cilium movement involved in cell motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)