Protein: Morphogenetic regulator of filamentous growth protein 1 (Q59Y46)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional regulator with a general role in all morphogenetically distinct forms of filamentous growth, namely invasive growth and biofilm formation. May control FLO11 gene expression as part of a promoter-bound complex with FLO8 and MSS1. Important for virulence
Subcellular location: Nucleus
Sequence: MNGNNNTGNLQQSHGPPQQQQQQQMFNQTPQMGFQQAPPPGMQGRGNNAQTPLQQQRFNMSQQQMMAAQQQQQQQQLQQQNAMAAAAAAAAASGRPVPQRNPNYNGSPNPGQTLPLNNNNNNSNNNNNKTGMYNPNALATGMPSSNLQPTSSAGNSRGHTPRMVNQPQPFIPHQQNQPPLPPQQQQQQQQQQQQPTPQLPPQGQTPQQVQMGYPKKVNNGNLVANQSLKSGPMGGPVPMGGPQQARIPPNSSFQQSPQTQFAMPPNSNGPINPQQQQQQHGPNQNPQPTVSGRSPIQRQMIIATTTATGGKGDTNNSVQEQVQQEINTRIIKRNLGNAAIIRVLDLIEFISNQHYENLSNIEFWTKITPANFLPTAILKFNTTNITGGNGNKSLNDITGLNLNFLNSNKATSNNNNNNTNTNTNNSNNNNKPHQFELTTSTAPRFFASCIQTESILKCNISLSGSKFQVLSNGSIVIVSKIGLHFHYKDGSNSALHGTIKILMSKDLRIEWVDLNFSDYQSNISVSALEEKLKSIITDNTSITKKDIKRQKELLDELVKNSQASKLQLTFGIEPQSLRILQLGDVMSSMKSLMEFSMVNNIPSPMKSMELLIASQKNQQMQAFQAQMAVQAQAQAQAQVQAQAQGQNLANFSGSTNLQTDAQRSRQQQQQQQQQQQQQQQQQSLNTSNNNSNSNNSNNNNNNNSNNNNNNNNNNNGKGGIANGSNNISSPSPRTVNAEEPKRKRKQSVNMSNENKRRK
InterPro domains: - IPR052145: Mediator complex and homeobox domain-containing protein (family) [141-646]
- IPR029005: LIM-domain binding protein/SEUSS (family) [341-609]
Interaction partners: - Transcriptional regulator of filamentous growth FLO8
- Transcription activator MSS11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)