Protein: Cyclic nucleotide-gated channel beta-3 (CNG channel beta-3) (Cone photoreceptor cGMP-gated channel subunit beta) (Cyclic nucleotide-gated cation channel beta-3) (Cyclic nucleotide-gated cation channel modulatory subunit) (Q9NQW8)
Organism: Homo sapiens (Human)
Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12815043}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ
InterPro domains: - IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [515-645]
- IPR000595: Cyclic nucleotide-binding domain (domain) [524-643]
- IPR018488: Cyclic nucleotide-binding, conserved site (conserved_site) [551-610]
- IPR050866: Cyclic nucleotide-gated cation channel (family) [19-805]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [450-640]
- IPR005821: Ion transport domain (domain) [220-451]
Interaction partners: - Cyclic nucleotide-gated channel alpha-3
- Guanine nucleotide-binding protein G
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
- Cyclic nucleotide-gated channel alpha-1
- Cyclic nucleotide-gated channel alpha-2
- Cyclic nucleotide-gated channel alpha-4
- Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
- Very long chain fatty acid elongase 4
- Retinal-specific phospholipid-transporting ATPase ABCA4
- Melanopsin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0030553 (cGMP binding), GO:0017076 (purine nucleotide binding), GO:0005216 (monoatomic ion channel activity), GO:0030551 (cyclic nucleotide binding), GO:0032555 (purine ribonucleotide binding), GO:0019001 (guanyl nucleotide binding), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0032561 (guanyl ribonucleotide binding), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0043855 (cyclic nucleotide-gated monoatomic ion channel activity), GO:0005217 (intracellular ligand-gated monoatomic ion channel activity), GO:0005221 (intracellular cyclic nucleotide activated monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0033036 (macromolecule localization), GO:0009581 (detection of external stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0035556 (intracellular signal transduction), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0098660 (inorganic ion transmembrane transport), GO:0071214 (cellular response to abiotic stimulus), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0034220 (monoatomic ion transmembrane transport), GO:0071496 (cellular response to external stimulus), GO:0007602 (phototransduction), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:0062149 (detection of stimulus involved in sensory perception of pain), GO:0050907 (detection of chemical stimulus involved in sensory perception), GO:0008104 (protein localization), GO:0050982 (detection of mechanical stimulus), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:0072657 (protein localization to membrane), GO:0022607 (cellular component assembly), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain), GO:0006812 (monoatomic cation transport), GO:0071468 (cellular response to acidic pH), GO:0098659 (inorganic cation import across plasma membrane), GO:0007606 (sensory perception of chemical stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005798 (Golgi-associated vesicle), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0060170 (ciliary membrane), GO:0030660 (Golgi-associated vesicle membrane), GO:0097708 (intracellular vesicle)