Protein: Prohibitin-1, mitochondrial (Atphb1) (O49460)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:12837548, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17883375, ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:21841088}; Single-pass type II membrane protein {ECO:0000269|PubMed:12837548, ECO:0000269|PubMed:14671022, ECO:0000269|PubMed:17883375, ECO:0000269|PubMed:18189341, ECO:0000269|PubMed:21841088}.
Sequence: MNNVKVPKIPGGGAISTLLKVGIIGGLGLYGATHSLYNVEGGHRAIMFNRLVGIKDKVYPEGTHLMIPWFERPVIYDVRARPYLVESTSGSRDLQMVKIGLRVLTRPMADQLPEIYRSLGENYSERVLPSIINETLKAVVAQYNASQLITQREAVSREIRKILTERAANFNVALDDVSITNLTFGKEFTAAIEAKQVAAQEAERAKFIVEKAEQDKRSAVIRAQGEAKSAQLIGQAIANNQAFITLRKIEAAREIAQTIANSANKVYLSSDDLLLNLQGMNLDVDAKN
InterPro domains: - IPR001107: Band 7 domain (domain) [35-213]
- IPR000163: Prohibitin (family) [2-283]
- IPR036013: Band 7/SPFH domain superfamily (homologous_superfamily) [64-203]
Interaction partners: - Prohibitin-3, mitochondrial
- Prohibitin-4, mitochondrial
- Prohibitin-5, mitochondrial
- SPFH/Band 7/PHB domain-containing membrane-associated protein family
- NADH dehydrogenase 1 beta subcomplex subunit 7
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Flotillin-like protein 3
- At5g54100
- Prohibitin-6, mitochondrial
- At5g40700
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:0048316 (seed development), GO:0009414 (response to water deprivation), GO:0048731 (system development), GO:0006970 (response to osmotic stress), GO:0071495 (cellular response to endogenous stimulus), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0090351 (seedling development), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:1902074 (response to salt), GO:0061458 (reproductive system development), GO:0097305 (response to alcohol), GO:0071310 (cellular response to organic substance), GO:0009651 (response to salt stress), GO:0009738 (abscisic acid-activated signaling pathway), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0009737 (response to abscisic acid), GO:1901701 (cellular response to oxygen-containing compound), GO:0010154 (fruit development), GO:0071215 (cellular response to abscisic acid stimulus), GO:0097306 (cellular response to alcohol), GO:0071396 (cellular response to lipid), GO:0071215 (cellular response to abscisic acid stimulus), GO:0097306 (cellular response to alcohol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005773 (vacuole), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:1990204 (oxidoreductase complex), GO:0030964 (NADH dehydrogenase complex), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0005740 (mitochondrial envelope), GO:0045271 (respiratory chain complex I), GO:0043231 (intracellular membrane-bounded organelle), GO:0005747 (mitochondrial respiratory chain complex I), GO:0019866 (organelle inner membrane), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)