Protein: Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) (Q9PTS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (By similarity). In vitro also decarboxylates pentacarboxylate porphyrinogen I.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P70697}.
Sequence: MMDKDSFILPKDFPELRNDTFLRAARGEEIEHIPVWCMRQAGRYLPEFRESRAGKDFFETCRSPEACCELTLQPLRRFPFDAAIIFSDILVVPQAMGMEVQMCPGKGPTFPEPLKEPEDLQRLKTQVDVYSELDYVFKAITLTRHKIEGKVPLIGFTGAPWTLMSYMIEGGGSATHSKAKRWLYRYPEASHKLLSQLTDVIVEYLLGQVKAGAQALQVFESHTGCLGPVEFKEFSLPYLRDIARRVKDKIKESGLDNVPMIVFAKDGHYGLEDLSESAYEVVGLDWTIDPRSARVRTGGKVSLQGNMDPCALYGTKESISEIVRRMLEGFGTKGYIANLGHGLYPDMDPENVGAFVEAVHNHSRQLLKR
InterPro domains: - IPR038071: UROD/MetE-like superfamily (homologous_superfamily) [6-368]
- IPR006361: Uroporphyrinogen decarboxylase HemE (family) [18-363]
- IPR000257: Uroporphyrinogen decarboxylase (URO-D) (domain) [17-362]
Interaction partners: - Protoporphyrinogen oxidase
- Uroporphyrinogen III synthase.
- Coproporphyrinogen oxidase.
- Ferrochelatase
- Hydroxymethylbilane synthase a.
- Delta-aminolevulinic acid dehydratase
- Hydroxymethylbilane synthase, b.
- Uncharacterized protein.
- 5-aminolevulinate synthase.
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0031018 (endocrine pancreas development), GO:0035270 (endocrine system development), GO:0003309 (type B pancreatic cell differentiation), GO:0002064 (epithelial cell development), GO:0060429 (epithelium development), GO:0031016 (pancreas development), GO:0030855 (epithelial cell differentiation), GO:0002066 (columnar/cuboidal epithelial cell development), GO:0003323 (type B pancreatic cell development), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0002068 (glandular epithelial cell development), GO:0002067 (glandular epithelial cell differentiation), GO:0035883 (enteroendocrine cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)