Protein: Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3) (P33622)
Organism: Mus musculus (Mouse)
Function: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02656}.
Sequence: MQPRTLLTVALLALLASARAEEVEGSLLLGSVQGYMEQASKTVQDALSSVQESDIAVVARGWMDNHFRFLKGYWSKFTDKFTGFWDSNPEDQPTPAIES
InterPro domains: - IPR038195: Apolipoprotein CIII superfamily (homologous_superfamily) [21-99]
- IPR008403: Apolipoprotein CIII (family) [1-98]
Interaction partners: - Apolipoprotein A-I
- Apolipoprotein C-II
- Apolipoprotein A-II
- Apolipoprotein B-100
- Apolipoprotein C-I
- Apolipoprotein E
- Apolipoprotein A-IV
- Apolipoprotein A-V
- Lipoprotein lipase
- Toll-like receptor 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0071814 (protein-lipid complex binding), GO:0071813 (lipoprotein particle binding), GO:0008035 (high-density lipoprotein particle binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0044281 (small molecule metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:1901615 (organic hydroxy compound metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051049 (regulation of transport), GO:1901360 (organic cyclic compound metabolic process), GO:0055088 (lipid homeostasis), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1905952 (regulation of lipid localization), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0044057 (regulation of system process), GO:0006810 (transport), GO:0006066 (alcohol metabolic process), GO:0043170 (macromolecule metabolic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:0006869 (lipid transport), GO:0043086 (negative regulation of catalytic activity), GO:0055092 (sterol homeostasis), GO:0051336 (regulation of hydrolase activity), GO:0008202 (steroid metabolic process), GO:0044058 (regulation of digestive system process), GO:0071702 (organic substance transport), GO:1904478 (regulation of intestinal absorption), GO:0042157 (lipoprotein metabolic process), GO:0032368 (regulation of lipid transport), GO:1904729 (regulation of intestinal lipid absorption), GO:0051346 (negative regulation of hydrolase activity), GO:0060191 (regulation of lipase activity), GO:0032371 (regulation of sterol transport), GO:0008203 (cholesterol metabolic process), GO:0042632 (cholesterol homeostasis), GO:0060192 (negative regulation of lipase activity), GO:0032374 (regulation of cholesterol transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005615 (extracellular space)