Protein: Glycosylphosphatidylinositol anchor biosynthesis protein 11 (PIGF homolog) (Q06636)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. Required for the formation of complete GPI precursors CP1 and CP2.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Sequence: MPAKKRTRKTVKKTVSFSDDTTLTTHQNREKKNVDHDRPPVYVRKTPLMTFPYHLVALLYYYVFVSSNFNTVKLLSFLIPTQVAYLVLQFNKCTVYGNKIIKINYSLTIICLGVTFLLSFPTMLLTILFGAPLMDLLWETWLLSLHFAFLAYPAVYSVFNCDFKVGLWKKYFIFIVVGGWISCVVIPLDWDRDWQNWPIPIVVGGYLGALVGYTIGAYI
InterPro domains: - IPR009580: GPI biosynthesis protein Pig-F (family) [54-216]
Interaction partners: - GPI ethanolamine phosphate transferase 3
- GPI mannosyltransferase 3
- GPI-anchor transamidase
- GPI ethanolamine phosphate transferase 2
- GPI transamidase component GPI16
- GPI transamidase component GPI17
- GPI transamidase component GAA1
- GPI transamidase component GAB1
- GPI mannosyltransferase 2
- GPI mannosyltransferase 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016780 (phosphotransferase activity, for other substituted phosphate groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046907 (intracellular transport), GO:0019538 (protein metabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0051668 (localization within membrane), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0071702 (organic substance transport), GO:0034645 (cellular macromolecule biosynthetic process), GO:0008104 (protein localization), GO:0042157 (lipoprotein metabolic process), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0042158 (lipoprotein biosynthetic process), GO:0006497 (protein lipidation), GO:0006612 (protein targeting to membrane), GO:0006605 (protein targeting), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:0018198 (peptidyl-cysteine modification), GO:0018345 (protein palmitoylation), GO:0018231 (peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine), GO:0018230 (peptidyl-L-cysteine S-palmitoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)