Protein: E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127) (Q13064)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Subcellular location: Nucleus {ECO:0000269|PubMed:34692086}.
Sequence: MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPVAPVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHDLSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPPAASSLSLPVIGSAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSSETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRACIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWRSARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRGNCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQLVEPVRMGEGNMLYKSIKKELVVLRLASLLFKRFLSLRDELPFSEDQWDLLHYELEEYFNLIL
InterPro domains: - IPR045072: MKRN-like (family) [100-427]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [335-344]
- IPR018957: Zinc finger, C3HC4 RING-type (domain) [311-364]
- IPR041367: E3 ligase, CCCH-type zinc finger (domain) [100-120]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [291-398]
- IPR031644: E3 ubiquitin-protein ligase makorin 1, C-terminal (domain) [422-507]
- IPR036855: Zinc finger, CCCH-type superfamily (homologous_superfamily) [96-120]
- IPR000571: Zinc finger, CCCH-type (domain) [95-423]
- IPR001841: Zinc finger, RING-type (domain) [311-365]
Interaction partners: - MAGE-like protein 2
- Small nuclear ribonucleoprotein-associated protein N
- Necdin
- Phospholipid-transporting ATPase VA
- SNRPN upstream reading frame protein
- Nuclear pore-associated protein 1
- Ubiquitin-protein ligase E3A
- P protein
- Gamma-aminobutyric acid receptor subunit beta-3
- Progonadoliberin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0003723 (RNA binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)