Protein: Acyl-CoA desaturase (B6K5G8)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Function: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MTPQATTTSSQPTAQSASKRAERQKVGGVIPVVPSVPQRRVDPNAPKHIIDQPWTLTNWYKHLNWLHVPLLFGLPLIALYGILTTPLNAKTAIFAFLYYFYSGLGITAGYHRLWSHRCYKASQPLQRFLEFGGAAAFEGSIRWWSRDHRAHHRYTDTDRDPYSVKKGFWYAHMGWMIIKQNPQRIGRADISDLNADPLVMHNHRSFLKIALFAAFIFPTLVCGLLWNDWRGGFFYAGVCRLVFVHHATFCVNSLAHLIGDQPFDDTNSARDHVLTALVTLGEGYHNFHHAFPNDYRNALKWYQYDPTKVFIWLCSLVGLSSQLKTFPKNEIQKGLVQQKQKQLDKWRTRLNWGVPLDQLPVMEFEEFLEQSKTRPLVLIAGVVHDMTGFDHPGGQALLRSSYGKDATAAFNGGVYDHTNGAHNLLANYRVAVVRGGMEVEVWKSGAGKQIPMKDTAGNGIVRSGQQITRTAVPVEAAAAN
InterPro domains: - IPR009160: Acyl-CoA desaturase, haem/steroid binding domain-containing (family) [16-449]
- IPR001199: Cytochrome b5-like heme/steroid binding domain (domain) [362-434]
- IPR015876: Acyl-CoA desaturase (family) [26-345]
- IPR001522: Fatty acid desaturase type 1, conserved site (conserved_site) [281-295]
- IPR036400: Cytochrome b5-like heme/steroid binding domain superfamily (homologous_superfamily) [352-443]
- IPR005804: Fatty acid desaturase domain (domain) [95-306]
Interaction partners: - Elongation of fatty acids protein
- Elongation of fatty acids protein
- Very-long-chain 3-oxoacyl-CoA reductase
- Enoyl reductase
- IPT/TIG ankyrin repeat protein
- Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
- Transcription factor Pap1/Caf3
- Tryptophan synthase
- Type I ferredoxin Etp1/cytochrome oxidase cofactor Cox15
- Short chain dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016717 (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water), GO:0016215 (acyl-CoA desaturase activity), GO:0004768 (stearoyl-CoA 9-desaturase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0033559 (unsaturated fatty acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0006636 (unsaturated fatty acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)