Protein: Nucleolar protein 19 (P53317)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Ribosome biogenesis factor required for cleavage of pre-rRNA at A0, A1 and A2 sites. Essential for the incorporation of UTP25 in pre-ribosomes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:21941128}.
Sequence: MSRAKELQEKLNLQAKLQSTFSNNTAAVLDWLKESDETGISNDTERNKQLKDHKELEDGKKAFFKLPVLQIGSGLHFRTQDDASAKEDIHTIGEFIEGDKKVSSLAKKKKRSDPGLQRNNMYRITKDDTKAMIALKRKMRKGEKEGLRKKQEHSKSSVSNSYSASDEEDEDAGTMPQKSTKKKFGLLFDKKKKARK
InterPro domains: - IPR022592: Nucleolar protein 19 (family) [1-148]
Interaction partners: - Protein SQS1
- Casein kinase II subunit alpha
- U3 small nucleolar RNA-associated protein 18
- U3 small nucleolar RNA-associated protein 13
- Casein kinase II subunit alpha'
- rRNA biogenesis protein RRP36
- Casein kinase II subunit beta
- U3 small nucleolar RNA-associated protein 22
- Probable ATP-dependent RNA helicase DHR2
- Something about silencing protein 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0010467 (gene expression), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis), GO:0016070 (RNA metabolic process), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0006396 (RNA processing), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0034470 (ncRNA processing), GO:0030490 (maturation of SSU-rRNA), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0000460 (maturation of 5.8S rRNA), GO:0000469 (cleavage involved in rRNA processing), GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic), GO:0016072 (rRNA metabolic process), GO:0000462 (maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000478 (endonucleolytic cleavage involved in rRNA processing), GO:0000447 (endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000466 (maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000479 (endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA))
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0140535 (intracellular protein-containing complex), GO:0030880 (RNA polymerase complex), GO:0043233 (organelle lumen), GO:0055029 (nuclear DNA-directed RNA polymerase complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0030684 (preribosome), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0000428 (DNA-directed RNA polymerase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0032040 (small-subunit processome), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)