Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q9V433)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MAHESAVHEALKKHFGHSKFKSDLQEKAVKCAVKKKQDVYVSMPTGSGKSLCFQLPGLMSENQITIVFSPLLALIKDQIDHLTKLKVPADSLNSKMSTKERDRVIMDLKAVRTNLKFLYITPEQAATKFFQDLLQTLHKHNKLAYFAVDEAHCVSQWGHDFRPDYLKLGELRSKYSDVIWLALTATASREVKEDIYKQLRLHQPVAQFSTPSFRKNLFYDIVYKNSIEDDFQHLADFARHCLGNPKEFKDTPKPQRGCGIVYCRTRDQVERMAIGVTKQGIGAVAYHAGLKTGERTEVQEAWMRGDQPIICATNSFGMGVDKPSVRFVIHWDVPQNVAAYYQESGRAGRDGLQSYCRLYYGREDVRSIRFLLQNDAHRARGRGDKELLTERAIKQFEKITEFCERTTCRHKLFSDFFGDPTPDCSGQCDVCKRPKKAEKALEIFHRLCMDDAFKSHISLQDCADLYEGGRPGIKRAAQEYAGGESGSDDDSGQSHSSMAKRAKKESQDFIKQQFNLRKQISAARQLEQETIAQISRVRMAEATEKKIAGLQATHREKYLTALIDALKANVDKCKDEPGQQPKSVLKYNDYEAMSVNMEYDVFRQNKVANMYRHALVKEISTIKKLTEQTKLLPLLVDYIPKPETSSKGAWTGGSVAYFERKLKELEEQRPQSLKEVPKALKDRKGFKQENSKQTSISSFFKKEIKEEPIDSPIQEERVNIKSEQMDLEESTPKDIASNHVKEESVTPESSSSDRELELQPDSIIGERKFKLMSNGDGSYDTHRRKRVSHETQPKEKESIKTKSSMQHLFGSFKSESEESNQSLNGFKTARQMLEENNSKLEGVPEKLPIKDGEKRVLENRADSIGFTSAREMLERSKQREGDDKSSNKLEKLGFISAREMLEKNKLNERCLDKKDVKEKKLESRETKRSLQNNELQHKQEEDRKDKASHRKTSKESLSNLKKEGSDSRVLQKDTKPETRNHQKTDVSKNVVQWLNPYYKRKIATKELFKALAKLLTQRICDGSLGDGDAGKCYIKETFHGLQMINNDQDIEKYFIKSK
InterPro domains: - IPR032284: ATP-dependent DNA helicase RecQ, zinc-binding domain (domain) [363-432]
- IPR013257: Set2 Rpb1 interacting domain (domain) [985-1021]
- IPR004589: DNA helicase, ATP-dependent, RecQ type (family) [10-436]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-449]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [16-222]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [23-193]
- IPR001650: Helicase, C-terminal domain-like (domain) [244-394]
Interaction partners: - DEAD-box ATP-dependent DNA helicase Fancm
- Crossover junction endonuclease MUS81
- DNA topoisomerase 3-alpha
- DNA topoisomerase 3-beta
- Serine/threonine-protein kinase ATR
- DNA repair protein Rad51 homolog
- DNA replication ATP-dependent helicase/nuclease
- Flap endonuclease 1
- DNA topoisomerase 1
- Double-strand break repair protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0140657 (ATP-dependent activity), GO:0036094 (small molecule binding), GO:0004386 (helicase activity), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0003678 (DNA helicase activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0140097 (catalytic activity, acting on DNA), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0017116 (single-stranded DNA helicase activity), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0009314 (response to radiation), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0098813 (nuclear chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0140014 (mitotic nuclear division), GO:0045930 (negative regulation of mitotic cell cycle), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0010212 (response to ionizing radiation), GO:0000819 (sister chromatid segregation), GO:0010165 (response to X-ray), GO:0048285 (organelle fission), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0000280 (nuclear division), GO:0006302 (double-strand break repair), GO:0045002 (double-strand break repair via single-strand annealing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)