Protein: Protein-lysine N-methyltransferase SMYD4 (Q08C84)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (By similarity). May also act as a histone methyltransferase. Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1
Subcellular location: Nucleus. Cytoplasm
Sequence: MDLPCQDWVCHVEQKWAELRSEETERFSLLTDIDAIFNYGLSLICPEDLNILSRISEKFSVKKSPETASEFRQQGNLSFKVKDYPAAVLHYSKGVCHADKNTDELSLCYANRSAALFYQGLYQACLEDIRRSLEAGYPSHLQDKLQTRQTACQNQLRKAEKPNIPHTDHQLSPCQKTVNSTGHLSDGVSVYFSSDKGRHMLVMENKPAGEVVLEDEAYCSVLIPANIFNTGTNKAVETFGTEDRHCHHCLSQSLSFVPCPKCSYARYCGESCQKDAWDQWHQWECPVGADLLAIGVLGHLALRVVLKAGQTEVQMGIKNTKDHVTTYKNDSPVQLSLGGDCGKSLDHTDCFHGSSYMGIYSLLPHVAQHSPASRFLMAITMAVIYGKLQGGPPPNKWMSFKDEGVKASWQPEMSMLGATALRHMMQLRCNAQAITAVRVKEESGMAVQSSSEIRIATAIFPVLSLLNHSCSPNTSISFTTGFQPDPHNQLGCSEGHFDHPKGSRSGVTVTVRASKDLTAGQEILHCYGPHRSRMEVKERQRLLLEQYFFQCVCQACQRDLSEGSPNAKEHTAPGMKCVKCGKPLQSHTDGYTCSWSSCGHQISSADVQNRLQGFQLLLDEAVHLMEQDRLNEALHILQSAFSQANSILTETHPFQGELADALARLYASTGEWSLAASHLKRSLVAIQAQFGEDSIELGRQLFKLAQLHFNGRDGVASLSVIPRARRLLSLHCSPRCEELQELSEMEHCLQGLL
InterPro domains: - IPR044421: SMYD4, SET domain (domain) [352-556]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [65-751]
- IPR046341: SET domain superfamily (homologous_superfamily) [184-554]
- IPR002893: Zinc finger, MYND-type (domain) [246-285]
- IPR052097: SET and MYND domain-containing protein (family) [6-748]
- IPR001214: SET domain (domain) [186-528]
Interaction partners: - Protein-lysine N-trimethyltransferase SMYD5
- PR domain zinc finger protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0009892 (negative regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048729 (tissue morphogenesis), GO:0044092 (negative regulation of molecular function), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009799 (specification of symmetry), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0035239 (tube morphogenesis), GO:0043086 (negative regulation of catalytic activity), GO:0060562 (epithelial tube morphogenesis), GO:0051246 (regulation of protein metabolic process), GO:0048562 (embryonic organ morphogenesis), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0009855 (determination of bilateral symmetry), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0060429 (epithelium development), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0051346 (negative regulation of hydrolase activity), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0001947 (heart looping), GO:0031057 (negative regulation of histone modification), GO:0031056 (regulation of histone modification), GO:0090311 (regulation of protein deacetylation), GO:0031063 (regulation of histone deacetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)