wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Protein sprouty homolog 4 (A0A8M9PQ80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MESRVPHHIPGVSSSIMVQPLLDSRVPYGRLQHPLTIYPIDQMKALHLENDYIDTPAVISQQPPSHKANPRGQEVLLGAPHHPNLSRCEVPDATTHPWISFSGRPSSISSSSSTSSDQRLLDHAAPTPVVDPYTTGNSHGRTLAAEQPKILSSKNIKTLAALPEEKKKHVLLCEKCGKCRCTECTLPRTLPSCWVCNQECLCSAQNLVDSVTCMCLVKGVFYHCTDEDEEGSCADKPCSCSHSNCCARWSFMAAVSLVLPCLVCYLPATGCAKLSQKCYDGVSRPGCRCKSTQSCKVAEIKACQPEKQAS
InterPro domains: - IPR051192: Sprouty domain-containing protein (family) [14-299]
- IPR007875: Sprouty (family) [175-290]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0030902 (hindbrain development), GO:0021593 (rhombomere morphogenesis), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:0021546 (rhombomere development), GO:0007420 (brain development), GO:0030097 (hemopoiesis), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0060537 (muscle tissue development), GO:0040037 (negative regulation of fibroblast growth factor receptor signaling pathway), GO:0007417 (central nervous system development), GO:0007517 (muscle organ development), GO:0040036 (regulation of fibroblast growth factor receptor signaling pathway), GO:0007519 (skeletal muscle tissue development), GO:0051146 (striated muscle cell differentiation), GO:0060538 (skeletal muscle organ development), GO:0014904 (myotube cell development), GO:0014902 (myotube differentiation), GO:0048741 (skeletal muscle fiber development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Asc-type amino acid transporter 1 (E7FE11)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MDGVERKKTEARRSIMKDSELKRDSGIPERVTLKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALVVWMLGGGVAALGSLCYAELGVTIPKSGGDYSYVTEIFGGLVGFLLLWSAVLIMYPTTLAVIALTFSSYVLQPVFPHCVPPYIATRMLSAICILFLTWVNCYSVRLATRIQDAFTVGKLLALGLIITVGLVQICGGNYESLTPQTAFTFNKAPSIGQIALAFLHASFAFSGWNFLNYVTEEVVDPRRNLPRAIYISIPLVTCVYTLTNIAYFSSMSPEELLSSNAVAVTFGEKLLGMFSTLMPISVALSTFGGINGYLFTSSRLCFSGAREGHLPSLLAMIHFKHCTPIPALLVCCTATIVILCIGETHNLINYVSFINYLSYGVTIAGLLYYRWKKPNLYRPIKVSLLVPVCYLLFWALLLAFSLHSEPLVCGVGLVIMLTGVPVYFLGVYWKDKPRCIYDFTEWATYLGQRVFFVVFPQIDPIELAEWTDKSSFTSKSSGHL
InterPro domains: - IPR002293: Amino acid/polyamine transporter I (family) [37-436]
- IPR050598: Cellular Amino Acid Transporter (family) [26-491]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0030097 (hemopoiesis), GO:0022008 (neurogenesis), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0002521 (leukocyte differentiation), GO:0030099 (myeloid cell differentiation), GO:0061515 (myeloid cell development), GO:0002573 (myeloid leukocyte differentiation), GO:0042063 (gliogenesis), GO:0030225 (macrophage differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Pyruvate kinase (Q6DG54)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MSQTKTTASGFIQTQQMPAAMAETFLEHLCLLDIDSEPTVSRNTGIVCTLGPASRSLETLREMILSGMNVARLNFSHGTHEYHAETIKSVREAIESFGAGTIDYRPVAIALDTKGPEIRTGLIKGSGTEEVKLVKGNIIKLTLDDKFMDNCDENTLWLDYKNITKVVQQGSHIYVDDGLISLKVKEIGSDFLNCEIENGGMLGSKKGVNLPGANVDLPAVSEKDIKDLQFGVEQGVDMVFASFIRKAADVHAVRKVLGEKGKDIRIISKLENHEGVRKFDEILEASDGIMVARGDLGIEIPTEKVFLAQKMMISRCNRIGKPIICATQMLESMIKKPRPTRAESSDVANAVLDGADCIMLSGETAKGEYPIESVLTQHLIAREAEAAMFHRQLFEELRRTSHLTRDPTESVAIGAVEASFKCCASAIICLTKTGRSAQLLSRYRPRAPIMAVTRNGQTSRQLHLYRGVIPILYTKPANDIWAEDVDLRVSFALEIGKHRKYFKSGDVIIVVTGWRPGSGYTNTMRIVVVP
InterPro domains: - IPR018209: Pyruvate kinase, active site (active_site) [264-276]
- IPR001697: Pyruvate kinase (family) [16-529]
- IPR015813: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (homologous_superfamily) [14-393]
- IPR015795: Pyruvate kinase, C-terminal (domain) [409-527]
- IPR015806: Pyruvate kinase, insert domain superfamily (homologous_superfamily) [116-218]
- IPR040442: Pyruvate kinase-like domain superfamily (homologous_superfamily) [44-384]
- IPR011037: Pyruvate kinase-like, insert domain superfamily (homologous_superfamily) [116-217]
- IPR015793: Pyruvate kinase, barrel (domain) [42-374]
- IPR036918: Pyruvate kinase, C-terminal domain superfamily (homologous_superfamily) [3-529]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004743 (pyruvate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: E3 ubiquitin-protein ligase LRSAM1 (A0A8M1NF66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MFLFKKKKPSGDSRKRLEYQLCLAKEAGADDILDISACELSEVPSCAFSMCKVLQKKVLILHTNDLRSLVPKGCCLGALATLKVLDLHENKLTSLPDEIGQLSSLQVLNAEKNQIKQLPDTIGGLLHLQTLNVKGNCLTVLPVSVGRMSSLRTLDISENSIRELPKELASVRTLESLILDAQVMSFPPASVCTGGTEEVQRYLCSDMGLEYCPPSQYLLPVLEHDGGKQEMDCVDGEEIVWQNKFMDYEKRKEQKQLEKLIFEKDLEEKQREHAKLLVLNSSLKEDVLLSVKLEQERLELGVSQQQKAQEAERLKVLDKVRQAESAVMSRISDLLLDNKRQEKSAAFLQALEKDRIRMEHLTTITQEEANSLRKKEVADAMQRMLSESCSVRLLQEAREAKTKFLVSETCKSLDNMDKKFDQVLSLQQLDKSKAISQILQEEEMQKAAFEALQLQKDSVHAYIRNQIKLIEAELMQLTKLEVKRRNLDTENLQEELSDQRTALTDLLQQLLKQKDQREEELRLVLMEIEKKSESNQQNYWMIQYQRLLDAKPLSLRMQEAAVDRDLGNLLCKLSAQHYLPIIAHHRITAEALRRMTAKDLRKLGINEVGVQKALLHWARDRTLSDPLPKTLKEMEEAGPFAQSVPLPHQLTPPLTPSAPLTPTTPNPDRFNSECVVCMELESQVIFLPCGHVCCCQTCSDALQSCPLCRGSISQRVRIYHG
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [674-709]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [555-622]
- IPR050216: Leucine-rich repeat domain-containing protein (family) [32-455]
- IPR001611: Leucine-rich repeat (repeat) [81-171]
- IPR055414: Disease resistance R13L4/SHOC-2-like, LRR domain (domain) [72-135]
- IPR001660: Sterile alpha motif domain (domain) [564-616]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [79-171]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [667-720]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [31-207]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0042110 (T cell activation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Tyrosine-protein kinase (Q1RLY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol
Sequence: MGNCGSFDPDDEFSYHPDEWCDQCNCPKPPVSQNFDPLIPYPSQYTPPPSSPLPENLVVAIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLCTRLVKPCQTRAPQKPWWQDEWEVPRESLKLERRLGQGQFGEVWMGLYNNNRQVAIKSLKPGTMSISAFLAEANLMKSLQHPRLVRLFAVVTQEPIYIITEYMENGSLVDFLKTPEGSDIPINTLIDMAAQVAEGMAYVEQKNYIHRDLRAANILVSHELTCKIADFGLARLIENNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVLLTEIVTYGRIPYPGMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVLEDFFTATEGQYQEQPC
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [56-165]
- IPR035749: Lck, SH3 domain (domain) [57-111]
- IPR001452: SH3 domain (domain) [53-114]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [111-257]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [238-486]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [225-491]
- IPR017441: Protein kinase, ATP binding site (binding_site) [244-266]
- IPR035850: Tyrosine-protein kinase Lck, SH2 domain (domain) [116-216]
- IPR000719: Protein kinase domain (domain) [238-491]
- IPR000980: SH2 domain (domain) [118-217]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [87-499]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [353-365]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [238-487]
Interaction partners: - CD4-1 molecule
- V(D)J recombination-activating protein 2
- V(D)J recombination-activating protein 1
- Tyrosine-protein kinase
- CD8 antigen, alpha polypeptide
- Interleukin 7 receptor
- Signal transducer and activator of transcription
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Basic helix-loop-helix transcription factor scleraxis (A0A8N7T827)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MSFAMVRPTPGHYLCSEINMHSEDDDNGSEGSGSEDKSFRTSSHGYGSFKLGVRKKRYSCRPLAIPTELCTPITEVRQRNTANARERERTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLVGEECGDGQPCLRSSGSLFHHHHNVSKSSTPSPDSENSQPRQICTFCLSNQRRLNKDRERKTVLRS
InterPro domains: - IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [73-138]
- IPR050283: E-box Binding Transcriptional Regulators (family) [16-194]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [77-135]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0048793 (pronephros development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Short transient receptor potential channel 4b (U3N7D8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSKRTETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKSTRANKSDTSASDVSHPEGSLQYSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSAVVLTEPILKDKARSDFPKDFTDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLAGKVEQDVNESKCLMEEDERVLEEQEMEHIASSHEH
InterPro domains: - IPR002153: Transient receptor potential channel, canonical (family) [9-785]
- IPR002110: Ankyrin repeat (repeat) [39-173]
- IPR005821: Ion transport domain (domain) [376-631]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [20-305]
- IPR013555: Transient receptor ion channel domain (domain) [176-238]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)
Protein: 5-hydroxytryptamine receptor 2B (Q0GH74)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Synapse, synaptosome
Sequence: MANVRQTDSVDWPSHWAALLILLVIVPTIGGNILVILAVSLERKLQNATNFFLMSLAVADLLVGLLVMPIALVTVLYNSTWPLADFLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQHSQFKSRAKVLAKIALVWLISIGIAIPIPIKGLQFFDHPNITFNKNHTCLLSPEGFRDFKVYGSLVAFFIPLAIMMIIYLLTIQVLRKKAYLLRSRAARPSISTVFQQELSVLASPEKMVISNGIKRDRTLNPVNPITGDEVPLRRMSTIGKRSMQNLTNEQRASKVLGIVFMLFVVMWCPFFITNVTSVLCERCNGNLVDQLLDIFQWVGYVSSGINPLVYTLFNRTFRLAFRRYITCNYKSVRTPKLQRRSKISFRSSVTENSKRFMKHGMKNGISPVGYQSPIRHRSTQLQTSANIMLDTLLLTDNEDCKPDEHVSHV
InterPro domains: - IPR000482: 5-Hydroxytryptamine 2B receptor (family) [121-427]
- IPR002231: 5-hydroxytryptamine receptor family (family) [35-350]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [16-359]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [31-344]
Interaction partners: - Guanine nucleotide-binding protein subunit alpha
- Guanine nucleotide-binding protein subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0043176 (amine binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0004888 (transmembrane signaling receptor activity), GO:0099589 (serotonin receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0004993 (G protein-coupled serotonin receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0007369 (gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0055113 (epiboly involved in gastrulation with mouth forming second), GO:0060429 (epithelium development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0001702 (gastrulation with mouth forming second), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane), GO:0097648 (G protein-coupled receptor complex)
Protein: Ribose-phosphate pyrophosphokinase 1 (Q6NYR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Sequence: MPNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINEWKNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKIQAQEFITLKIMI
InterPro domains: - IPR000842: Phosphoribosyl pyrophosphate synthetase, conserved site (conserved_site) [128-143]
- IPR029099: Ribose-phosphate pyrophosphokinase, N-terminal domain (domain) [4-120]
- IPR029057: Phosphoribosyltransferase-like (homologous_superfamily) [6-289]
- IPR000836: Phosphoribosyltransferase domain (domain) [147-274]
- IPR005946: Ribose-phosphate pyrophosphokinase (family) [1-294]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016778 (diphosphotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)