Protein: Kruppel-like factor 1 (Erythroid krueppel-like transcription factor) (Kruppel-like factor d) (Q90XE6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription regulator. Plays a role in erythropoiesis, binding to promoters and activating transcription of embryonic alpha globin e1 hbae1.1 and microRNA mir-144, in erythroid progenitors; perhaps acting as part of a negative feedback loop with mir-144. May coordinate repression of genes controlling myocardial differentiation and mitochondrial metabolism with positive modulation of cell proliferation genes. Required for regeneration of the myocardium after injury, probably acting by stimulating renewal of preexisting cardiomyocytes in adult hearts.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:33833125}. Nucleus {ECO:0000305|PubMed:18941117, ECO:0000305|PubMed:33833125}. Note=Colocalizes with the cytosolic muscle marker troponin C. {ECO:0000269|PubMed:33833125}.
Sequence: MAVTQAVLPSFSNFCTNSENMKFEKGFLDLDSKDLHQSPASYKPSQFLTDEHQDDSEGCWDMEFLLSDWASMSPERSNSQNYTPQRPTLQDQLHSPDLYQELNAPKPNRHQVCVASSLAELLPPEATLSSSLPPDLQFNCGFLDQQAAKSYSQAENPQQFSAFPVTSNVNRDSSMGKMGKSWDFGHYYQPAPLISFPDSKFVQTQGITMETVVFPPHHHYNFIPSYSHPRLYQQQANYVHRPPPQSHFPSTQSMVPDSTVPPAGLESKRIRRGLVKRKATVHSCEYPGCQKTYTKSSHLKAHLRTHTGEKPYHCTWDGCGWKFARSDELTRHFRKHTGQKPYECLLCHRAFSRSDHLALHMKRHV
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [282-365]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [296-364]
Interaction partners: - GATA-binding protein 1a.
- T-cell acute lymphocytic leukemia protein 1 homolog
- Endothelial transcription factor GATA-2a
- Rhombotin-2
- LIM domain-binding protein 1-A.
- 5-aminolevulinate synthase, erythroid-specific, mitochondrial
- Hemoglobin subunit beta-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035265 (organ growth), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0002262 (myeloid cell homeostasis), GO:0040012 (regulation of locomotion), GO:0035295 (tube development), GO:0021675 (nerve development), GO:0042127 (regulation of cell population proliferation), GO:2000145 (regulation of cell motility), GO:0034101 (erythrocyte homeostasis), GO:0048468 (cell development), GO:0021603 (cranial nerve formation), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0021602 (cranial nerve morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0071695 (anatomical structure maturation), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0007399 (nervous system development), GO:0030218 (erythrocyte differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0055123 (digestive system development), GO:0072091 (regulation of stem cell proliferation), GO:0021545 (cranial nerve development), GO:0031326 (regulation of cellular biosynthetic process), GO:0048732 (gland development), GO:0043249 (erythrocyte maturation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0030334 (regulation of cell migration), GO:0030099 (myeloid cell differentiation), GO:0048565 (digestive tract development), GO:0061008 (hepaticobiliary system development), GO:0010468 (regulation of gene expression), GO:0031016 (pancreas development), GO:0061515 (myeloid cell development), GO:0048821 (erythrocyte development), GO:0001889 (liver development), GO:0021554 (optic nerve development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)