Protein: DNA (cytosine-5-)-methyltransferase (Q588C2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MHPPTHTQRPKRDGDQQTQRHVWEKKVRLVQMSDTMDHQSAVGSQEDEPAMILPTIPIGGSRDKAGKKFEKKVRLVQMSDTMDHQSAVGSQEDEPAMILPTIPIGGSRDKAGKKFEKKVHLVLMSDTMDGQSAVGSQEDEPAMILPTIPQQQQKKVRLVLMSDTMDDQSAVGSQEDEPAMILPAIPQQQHTDPASPTVATTPEPPPVACGEKVLTGIAPIHQEYQDGLGYGIGELVWGKLRGFSWWPGRIVSCWITNRGPAAEGTRWVMWFGDGKLSMMCVEKLLPLSAFSKTFHQPTYNKQPVYRKAIFQVLLTGGLRAGKPFPHCEYTNYTPEGKMEENETQAQQMIKWASTGFLPSGPKGLEPPPAERNPYTEVYPEMWEPEAASYTAPPPAKKPRKNSVEKTKIKEIIDEGTRERLMLEVKQKCRNIEDICISCGSLNVTLEHPLFVGAMCQSCKNSFLECAYQYDEDGYQSFCTICCGGRQVLMCGNNNCCRCYCVECVDLLVGTGCAQAAISEDPWNCYMCCSRSVFGLLRRRDDWTSRLQLFFANNHDQDFEPPALYSPVAPEKRQPIRVLSLFDGIATGLLVLKDLGIQVDRYVASEVCEDSITVGMVRHFERITYVGDIRNITRKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLFEGTGRLFFEFYRLLHEARPKEGDDRPFFWLFENVVAMGVSDKKDISRFLECNPVMIDAKEVSAAHRARYFWGNLPGMNRPLTAMVNDKLDLQDCLEHGRTAKFNKVRTITTRSNSIKQGKDQHYPVYMNNKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKEYFAC
InterPro domains: - IPR025766: ADD domain (domain) [423-555]
- IPR040552: DNMT3, cysteine rich ADD domain, GATA1-like zinc finger (domain) [416-471]
- IPR018117: DNA methylase, C-5 cytosine-specific, active site (active_site) [643-655]
- IPR050390: DNA Cytosine-5 Methyltransferase (family) [43-681]
- IPR044108: DNA (cytosine-5)-methyltransferase 3A, ADD domain (domain) [428-555]
- IPR049554: DNMT3, ADD domain, PHD zinc finger (domain) [478-527]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [563-852]
- IPR001525: C-5 cytosine methyltransferase (family) [575-852]
- IPR000313: PWWP domain (domain) [230-309]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0140097 (catalytic activity, acting on DNA), GO:0009008 (DNA-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0003886 (DNA (cytosine-5-)-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0003002 (regionalization), GO:0046483 (heterocycle metabolic process), GO:0009799 (specification of symmetry), GO:0045595 (regulation of cell differentiation), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0048872 (homeostasis of number of cells), GO:0009855 (determination of bilateral symmetry), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:0043412 (macromolecule modification), GO:0060972 (left/right pattern formation), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:2000736 (regulation of stem cell differentiation), GO:0061484 (hematopoietic stem cell homeostasis), GO:0006306 (DNA methylation), GO:1902036 (regulation of hematopoietic stem cell differentiation), GO:0007368 (determination of left/right symmetry), GO:0006304 (DNA modification), GO:0032776 (DNA methylation on cytosine), GO:0006305 (DNA alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)