Protein: Neurofibromin 1, isoform D (Q59DT9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MTQKPGEWASALLARFEDQLPNRIGAYGTQARMSQDQLVACLIHISRYRFSLVISGLTKMLQRVNEAALQNRHEPERCYFESLVIILTTLERCLTNQTKDTARFEEAMNVKLLLREISQFVDVQSDSNPNAAQLKALASKVLFALSQNHFSAVFNRISARIQELTSCSEENPDYNDIELIQHIDMDMIKLTKLLQETITKFRSKRAPPLILLYSLEKAIWNWIEYHPQEFQDLQRGTNRDISTCWEPLMDFVEYFKTENKKSKTLVWPLQMLLLILNPSCLEAVVNELQQSEKEKEKDKEKVASKSAQSTSRDKDFSAKQFIESIKRGLGQHSPSKQVTESAAIACVKLCKASTYINNTDSNNVVFKLVQFFINDLKALLFNPAKPFSRGQGYNFADIELMIDCWVSCFRINPHNIEALKVCLNLSSPQAYHFVIVCSLLRLAHIYVDFRLQNKNPFRIVNQPRLSWWPQTDVVHYRSAELRALFTDTLNKATQGYIAHTPLRYITSLTLKSKDTQKGLTRAEEGPAHKMLLLLLVRLIHADPTLLLNTQGKVAHEVQSSTLELINGLVSLVHQTTMPDVAQEAMEALLALHAPEKIEVWNPEAPINTFWDVSSQVLFSISQKLIQHQIANYTDVLKWLREILICRNTFLQRHKDYAHVGSQIAICKQAHIKMEVVFFMYLWSVDLDAVLTSLSCFGLLCEEAEICCSSDELTVGFIMPNYHIYQELAQLSTSATDSRICFFDNTHGNVLSRLTLQKRIMTLLRKIEHCVHGVQPAWEETFRNWEVSSKVLQTYPKCKGEDGQAEVFHRGMGKRRASHQSSEHDLEEQINEWANMTWFLLALGGVCLHKRSSSRQMLLQQSQNNASLGSLAQNSLYSSSTSSGHGSLHPSTVSLSTLPPAPPQDVSYCPVTQFVGQLLRLLVCSNEKIGLNIQKNVKELVGEEMSTQLYPILFDQVRAIVEKFFDQQGQVNVNVTDINTQFIEHTIYIMKSILDPKANKDPNNDQPSPSEHLGVTSIEGMMLGIVRYVRHLDMTVYAIRIKTKLCQLVEVMMKRRDDLAFRQEMKFRNKLVEYLTDWVMGTSHQIAPPSSADAAILTNTSLIFRDLDQACMEAVAALLRGLPLQPEESDRGDLMDAKSALFLKYFTLFMNLLNDCIDSSEAEKEMNNTPLLPPRPRMAAGKLTALRNATILAMSNLLGANIDSGLMHSIDLGYNPDLQTRAAFMEVLTQILQQGTEFDTLAETVLADRFEQLVQLVTMISDKGELPIAMALANVVTTSQMDELARVLVTLFDAKHLLSPLLWNMFYREVEVSDCMQTLFRGNSLGSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTEDIEQHRNNLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNIGAVGTVIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMSKILQNIANHVEFSKEQHMLCFNDFLRDHFEAGRRFFIQIASDCETVDQTSHSMSFISDANVLALHRLLWTHQEKIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHKPVDSHMMFSSYARWSSIDMSSTNFEEIMVKHQMHEKEEFKTLKSMNIFYQAGTSKSGYPVFYYIARRYKIGETNGDLLIYHVILTLKPFCHSPFEVVIDFTHTCSDNRFRTEFLQKWFYVLPTVAYENVHAVYIYNCNSWVREYTKFHDRILAPLKGNRKLLFLESPNKLTDFIDAEQQKLPGATLSLDEDLKVFSNALKLSHKDTKVAIKVGPTALQITSAEKTKVLAHSVLLNDVYYASEIEEVCLVDDNQFTLSITNESGQLSFIHNDCDNIVQAIIHIRNRWELSQPDSVTVHQKIRPKDVPGTLLNMALLNLGSCDPNLRTAAYNLLCALTATFDLKIEGQLLETQGLCIPSNNTIFIKSVSEKLATNEPHLTLEFLEESIQGFQRSTIELKHLCLEYMTPWLKNLVKFCKSNDDSKKLKVSQILDKLINLTIDQKEMYPSVQAKIWGSIGQIPELIDMVLDNFLHKSITYGLGSPQVEIMADTAVALASANVQLVSKKVITRICRVMDKSCTNPTQYLEQHMMWDDIAILGRYLLMLSFNNCLDVATSVPYLFHTITFLVCSGSLSMRASTHGLVINIIHSLCTCTNPSFSEEAQRVLRLSLDEFSLPKFYLLFGISKVKSAAVTAFRSSCRHPTDKWLGNERVTQPLPADRERLSLPSLEVITDALLEIMEACMRDVPDCEWLNTWTSLARSFAFCYNPALQPRALIVYGCISKSVTDHEVKQLLRILVKALESFNDLILIEALVMCLTRIQPLLRPESPIHRALFWVAISVLQLDEITLYGAGLALLEQNLHTLKSQGCFDKKETIAEVMMKTREKLEWHFKQLDHAVGLSFRSNFHFALVGHLIKGFRHPTPTTVSRTSRVLTMLLGIIAKPLHRDKFEVTPDSVAYLTALVAVSEEVRSRCHVKHALPRWPADLSSSVENGEASGGVQAIGLPLSRRQKSWDILDQSALQFARQHKVPTLQNARVLFKTQRSFSVPTTKDPNNATGIEERQERGSRSSVSNESNVLLDPEVLPDLSIQALVLTVLATLVKYSSDEGETRVLYQYLAEGSVVFPKVFPVIHSLLDQKINNILSVSHDQVVLNSVQNIIQNMLASEDPSQQQLHFLQSCGFGGLWRFAGPFTKYNMMGESSELFVNCLEAMVETCLPGDESAPVPPSPRPYNLSSSLSSLTLGSPTDKAA
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [320-2683]
- IPR001251: CRAL-TRIO lipid binding domain (domain) [1611-1769]
- IPR054071: Neurofibromin, PH domain-like (domain) [1768-1862]
- IPR039360: Ras GTPase-activating protein (family) [62-2021]
- IPR001936: Ras GTPase-activating domain (domain) [1227-1581]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [1242-1573]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [1612-1757]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1758-1868]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048589 (developmental growth), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0008340 (determination of adult lifespan), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0007623 (circadian rhythm), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0003008 (system process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0016049 (cell growth), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0007165 (signal transduction), GO:0048639 (positive regulation of developmental growth), GO:0009266 (response to temperature stimulus), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051129 (negative regulation of cellular component organization), GO:0035556 (intracellular signal transduction), GO:0006979 (response to oxidative stress), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0048512 (circadian behavior), GO:0050803 (regulation of synapse structure or activity), GO:0030534 (adult behavior), GO:0044087 (regulation of cellular component biogenesis), GO:0007626 (locomotory behavior), GO:0009408 (response to heat), GO:0048588 (developmental cell growth), GO:2000026 (regulation of multicellular organismal development), GO:0040018 (positive regulation of multicellular organism growth), GO:0040014 (regulation of multicellular organism growth), GO:0010646 (regulation of cell communication), GO:0007635 (chemosensory behavior), GO:0007611 (learning or memory), GO:0048640 (negative regulation of developmental growth), GO:0050877 (nervous system process), GO:0051128 (regulation of cellular component organization), GO:0007622 (rhythmic behavior), GO:0048638 (regulation of developmental growth), GO:0051964 (negative regulation of synapse assembly), GO:0050890 (cognition), GO:0050807 (regulation of synapse organization), GO:0045475 (locomotor rhythm), GO:1901888 (regulation of cell junction assembly), GO:0031279 (regulation of cyclase activity), GO:0007612 (learning), GO:0051960 (regulation of nervous system development), GO:1901889 (negative regulation of cell junction assembly), GO:0007613 (memory), GO:1905809 (negative regulation of synapse organization), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0008344 (adult locomotory behavior), GO:0051339 (regulation of lyase activity), GO:0045886 (negative regulation of synaptic assembly at neuromuscular junction), GO:0008582 (regulation of synaptic assembly at neuromuscular junction), GO:0007264 (small GTPase mediated signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:1902531 (regulation of intracellular signal transduction), GO:0042048 (olfactory behavior), GO:0008355 (olfactory learning), GO:0045761 (regulation of adenylate cyclase activity), GO:0031281 (positive regulation of cyclase activity), GO:1904397 (negative regulation of neuromuscular junction development), GO:1904396 (regulation of neuromuscular junction development), GO:0051963 (regulation of synapse assembly), GO:0007265 (Ras protein signal transduction), GO:0042063 (gliogenesis), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0007616 (long-term memory), GO:0051349 (positive regulation of lyase activity), GO:0007614 (short-term memory), GO:0008306 (associative learning), GO:0046578 (regulation of Ras protein signal transduction), GO:0045762 (positive regulation of adenylate cyclase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0045179 (apical cortex), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0098562 (cytoplasmic side of membrane), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0098592 (cytoplasmic side of apical plasma membrane), GO:0005911 (cell-cell junction), GO:0099738 (cell cortex region), GO:0005912 (adherens junction)