Protein: Signal transducer and activator of transcription (A0A384N5W4)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU046415}.
Sequence: MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
InterPro domains: - IPR001217: Transcription factor STAT (family) [1-726]
- IPR048988: Signal transducer and activator of transcription, linker domain (domain) [492-574]
- IPR012345: STAT transcription factor, DNA-binding, N-terminal (homologous_superfamily) [333-471]
- IPR015988: STAT transcription factor, coiled coil (homologous_superfamily) [136-332]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [327-584]
- IPR036535: STAT transcription factor, N-terminal domain superfamily (homologous_superfamily) [1-128]
- IPR013799: STAT transcription factor, protein interaction (domain) [2-126]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [587-703]
- IPR013801: STAT transcription factor, DNA-binding (domain) [336-469]
- IPR046994: STAT5a/5b, coiled-coil domain (domain) [139-330]
- IPR035858: STAT5a/5b, DNA-binding domain (domain) [332-489]
- IPR013800: STAT transcription factor, all-alpha domain (domain) [146-324]
- IPR000980: SH2 domain (domain) [587-700]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0140297 (DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0019222 (regulation of metabolic process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0010632 (regulation of epithelial cell migration), GO:0042127 (regulation of cell population proliferation), GO:2000145 (regulation of cell motility), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0080090 (regulation of primary metabolic process), GO:2000147 (positive regulation of cell motility), GO:0008284 (positive regulation of cell population proliferation), GO:0010594 (regulation of endothelial cell migration), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0097696 (receptor signaling pathway via STAT), GO:0031326 (regulation of cellular biosynthetic process), GO:0010634 (positive regulation of epithelial cell migration), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0030335 (positive regulation of cell migration), GO:0051252 (regulation of RNA metabolic process), GO:0030334 (regulation of cell migration), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0001938 (positive regulation of endothelial cell proliferation), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0001936 (regulation of endothelial cell proliferation), GO:2001141 (regulation of RNA biosynthetic process), GO:0010595 (positive regulation of endothelial cell migration), GO:0007259 (receptor signaling pathway via JAK-STAT), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0043536 (positive regulation of blood vessel endothelial cell migration), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)