Protein: Neurogenic locus notch homolog protein 1 (P46530)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence: MNRFLVKLTLLTAASLATVAQGQRCSEYCQNGGICEYKPSGEASCRCPADFVGAQCQFPNPCNPSPCRNGGVCRPQMQGNEVGVKCDCVLGFSDRLCLTPVNHACMNSPCRNGGTCSLLTLDTFTCRCQPGWSGKTCQLADPCASNPCANGGQCSAFESHYICTCPPNFHGQTCRQDVNECAVSPSPCRNGGTCINEVGSYLCRCPPEYTGPHCQRLYQPCLPSPCRSGGTCVQTSDTTHTCSCLPGFTGQTCEHNVDDCTQHACENGGPCIDGINTYNCHCDKHWTGQYCTEDVDECELSPNACQNGGTCHNTIGGFHCVCVNGWTGDDCSENIDDCASAACSHGATCHDRVASFFCECPHGRTGLLCHLDDACISNPCQKGSNCDTNPVSGKAICTCPPGYTGSACNQDIDECSLGANPCEHGGRCLNTKGSFQCKCLQGYEGPRCEMDVNECKSNPCQNDATCLDQIGGFHCICMPGYEGVFCQINSDDCASQPCLNGKCIDKINSFHCECPKGFSGSLCQVDVDECASTPCKNGAKCTDGPNKYTCECTPGFSGIHCELDINECASSPCHYGVCRDGVASFTCDCRPGYTGRLCETNINECLSQPCRNGGTCQDRENAYICTCPKGTTGVNCEINIDDCKRKPCDYGKCIDKINGYECVCEPGYSGSMCNINIDDCALNPCHNGGTCIDGVNSFTCLCPDGFRDATCLSQHNECSSNPCIHGSCLDQINSYRCVCEAGWMGRNCDININECLSNPCVNGGTCKDMTSGYLCTCRAGFSGPNCQMNINECASNPCLNQGSCIDDVAGFKCNCMLPYTGEVCENVLAPCSPRPCKNGGVCRESEDFQSFSCNCPAGWQGQTCEVDINECVRNPCTNGGVCENLRGGFQCRCNPGFTGALCENDIDDCEPNPCSNGGVCQDRVNGFVCVCLAGFRGERCAEDIDECVSAPCRNGGNCTDCVNSYTCSCPAGFSGINCEINTPDCTESSCFNGGTCVDGISSFSCVCLPGFTGNYCQHDVNECDSRPCQNGGSCQDGYGTYKCTCPHGYTGLNCQSLVRWCDSSPCKNGGSCWQQGASFTCQCASGWTGIYCDVPSVSCEVAARQQGVSVAVLCRHAGQCVDAGNTHLCRCQAGYTGSYCQEQVDECQPNPCQNGATCTDYLGGYSCECVPGYHGMNCSKEINECLSQPCQNGGTCIDLVNTYKCSCPRGTQGVHCEIDIDDCSPSVDPLTGEPRCFNGGRCVDRVGGYGCVCPAGFVGERCEGDVNECLSDPCDPSGSYNCVQLINDFRCECRTGYTGKRCETVFNGCKDTPCKNGGTCAVASNTKHGYICKCQPGYSGSSCEYDSQSCGSLRCRNGATCVSGHLSPRCLCAPGFSGHECQTRMDSPCLVNPCYNGGTCQPISDAPFYRCSCPANFNGLLCHILDYSFSGGQGRDIAPPVEVEIRCEIAQCEGRGGNAICDTQCNNHACGWDGGDCSLNFDDPWQNCSAALQCWRYFNDGKCDEQCATAGCLYDGFDCQRLEGQCNPLYDQYCRDHYADGHCDQGCNNAECEWDGLDCADDVPQKLAVGSLVLVVHIPPDELRNRSSSFLRELSSLLHTNVVFRRDANGEALIFPYYGSEHELSKHKRSDWTDPGQLMQRARRSLTSFLKPRTRRELDHMEVKGSIVYLEIDNRQCFQQSDECFQSATDVAAFLGALASSGNLNVPYIIEAVTSEGGPPKTGEMYPMFLVLLALAVLALAAVGVVVSRKRKREHGQLWFPEGFKVNEPKKKRREPVGEDSVGLKPLKNSDSSLMDEQLSEWAEDDTNKRFRFEGQSILEMSGQLDHRQWTQQHLDAADLRLNSMAPTPPQGQIENDCMDVNVRGPDGFTPLMIASCSGGGLENENGEAEEDPSADVITDFIYHGANLHNQTDRTGETALHLAARYARSDAAKRLLESCADANVQDNMGRTPLHAAVAADAQGVFQILIRNRATDLDARMHDGTTPLILATRLAVEGMVEELINCHADPNAVDDSGKSALHWAAAVNNVDAAVVLLKNGANKDLQNNKEETPLFLAAREGSYETAKVLLDHLANRDIADHLDQLPRDIAHERMHHDIVRLLEEYNLVRSPPLPLSPPLCCPNTYLGIKPSPGNNNNTAKKTRKPGGKGVGGKDSGKDIRTKKKKSGDGKNGGIMEVGVLSPVDSLESPHGYLSDVSSPPMMTSPFQQSPPISLNQLQGLADSHMGGALQGLGKPFDSAPRLSHLPVANNVGGAQAGACDWLQRVQQQQQQQQQQQQAGMLMPTMLSATNMPQVMGYPTMQSSHLGAPSHMIAHQNMAPMQHQNISHHFLGDLSGLDLQSSSGHAPIQTILPQDSQRMAPPISSTQFLTPPSQHSYSNPMDNTPNHQQVPDHPFLTPSAGSPDQWSSSSPHSNLSDWSEGISSPPTSMQMNHIPEAFK
InterPro domains: - IPR000742: EGF-like domain (domain) [21-1423]
- IPR035993: Notch-like domain superfamily (homologous_superfamily) [1446-1559]
- IPR011656: Notch, NODP domain (domain) [1662-1724]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [177-1251]
- IPR051355: Notch and Slit guidance protein (family) [85-1362]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [194-1253]
- IPR002110: Ankyrin repeat (repeat) [1867-2101]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [177-444]
- IPR008297: Notch (family) [5-2429]
- IPR000800: Notch domain (domain) [1440-1566]
- IPR010660: Notch, NOD domain (domain) [1564-1620]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [1856-2113]
- IPR022362: Neurogenic locus notch homolog protein 1 (family) [1423-2266]
- IPR001881: EGF-like calcium-binding domain (domain) [105-1382]
- IPR013032: EGF-like, conserved site (conserved_site) [265-1376]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [287-1310]
- IPR024600: Notch, C-terminal (domain) [2363-2425]
Interaction partners: - Protein jagged-1a
- Protein jagged-1b
- NUMB-like endocytic adaptor protein
- Recombination signal-binding protein for immunoglobulin kappa J region b
- Catenin beta-1
- Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
- ADAM metallopeptidase domain 17b
- Hairy/enhancer-of-split related with YRPW motif protein 1
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0038023 (signaling receptor activity), GO:0003712 (transcription coregulator activity), GO:0003713 (transcription coactivator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0032879 (regulation of localization), GO:0007389 (pattern specification process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051093 (negative regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032989 (cellular component morphogenesis), GO:0051049 (regulation of transport), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0060627 (regulation of vesicle-mediated transport), GO:0010453 (regulation of cell fate commitment), GO:0021986 (habenula development), GO:0000902 (cell morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0021536 (diencephalon development), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060322 (head development), GO:0045596 (negative regulation of cell differentiation), GO:0045597 (positive regulation of cell differentiation), GO:0030900 (forebrain development), GO:0021517 (ventral spinal cord development), GO:0021538 (epithalamus development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0030100 (regulation of endocytosis), GO:0030097 (hemopoiesis), GO:0021510 (spinal cord development), GO:0035282 (segmentation), GO:0030030 (cell projection organization), GO:0055123 (digestive system development), GO:0001944 (vasculature development), GO:0032990 (cell part morphogenesis), GO:0060284 (regulation of cell development), GO:0021522 (spinal cord motor neuron differentiation), GO:0048732 (gland development), GO:1903224 (regulation of endodermal cell differentiation), GO:0010001 (glial cell differentiation), GO:0051960 (regulation of nervous system development), GO:0035272 (exocrine system development), GO:0061053 (somite development), GO:0021515 (cell differentiation in spinal cord), GO:0048666 (neuron development), GO:0007219 (Notch signaling pathway), GO:0007420 (brain development), GO:0009855 (determination of bilateral symmetry), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0042659 (regulation of cell fate specification), GO:0050768 (negative regulation of neurogenesis), GO:0048568 (embryonic organ development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0060972 (left/right pattern formation), GO:0010455 (positive regulation of cell fate commitment), GO:0072359 (circulatory system development), GO:0007422 (peripheral nervous system development), GO:0021514 (ventral spinal cord interneuron differentiation), GO:0007417 (central nervous system development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0060429 (epithelium development), GO:1905770 (regulation of mesodermal cell differentiation), GO:0010721 (negative regulation of cell development), GO:0048858 (cell projection morphogenesis), GO:2000027 (regulation of animal organ morphogenesis), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0031016 (pancreas development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060840 (artery development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0042661 (regulation of mesodermal cell fate specification), GO:0043009 (chordate embryonic development), GO:0007368 (determination of left/right symmetry), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0042663 (regulation of endodermal cell fate specification), GO:0048934 (peripheral nervous system neuron differentiation), GO:0060218 (hematopoietic stem cell differentiation), GO:0021953 (central nervous system neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048935 (peripheral nervous system neuron development), GO:0031017 (exocrine pancreas development), GO:0042063 (gliogenesis), GO:0035904 (aorta development), GO:0001840 (neural plate development), GO:0031175 (neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0048812 (neuron projection morphogenesis), GO:0048936 (peripheral nervous system neuron axonogenesis), GO:0061564 (axon development), GO:0035907 (dorsal aorta development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)