Protein: Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.1) (EC 2.8.2.2) (Q6IMI6)
Organism: Homo sapiens (Human)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor. Has sulfotransferase activity towards various substrates, such as bile acids, thyroid hormones and toward xenobiotic compounds such as chloro phenols and hydroxypyrenes. Lithocholic acid appears to be the best substrate among the endogenous compounds tested and 3,3',5,5'-tetrachloro-4,4'-biphenyldiol shows the highest specific activity among the xenobiotic compounds.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q80VR3}.
Sequence: MAKIEKNAPTMEKKPELFNIMEVDGVPTLILSKEWWEKVCNFQAKPDDLILATYPKSGTTWMHEILDMILNDGDVEKCKRAQTLDRHAFLELKFPHKEKPDLEFVLEMSSPQLIKTHLPSHLIPPSIWKENCKIVYVARNPKDCLVSYYHFHRMASFMPDPQNLEEFYEKFMSGKVVGGSWFDHVKGWWAAKDMHRILYLFYEDIKKDPKREIEKILKFLEKDISEEILNKIIYHTSFDVMKQNPMTNYTTLPTSIMDHSISPFMRKGMPGDWKNYFTVAQNEEFDKDYQKKMAGSTLTFRTEI
InterPro domains: - IPR000863: Sulfotransferase domain (domain) [46-296]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [10-304]
Interaction partners: - Carbohydrate sulfotransferase 6
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Heparan sulfate glucosamine 3-O-sulfotransferase 1
- Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
- Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
- Heparan sulfate glucosamine 3-O-sulfotransferase 2
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0008146 (sulfotransferase activity), GO:0004062 (aryl sulfotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006066 (alcohol metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0006805 (xenobiotic metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0030638 (polyketide metabolic process), GO:0006793 (phosphorus metabolic process), GO:0050427 (3'-phosphoadenosine 5'-phosphosulfate metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:1902644 (tertiary alcohol metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0034308 (primary alcohol metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901661 (quinone metabolic process), GO:1901657 (glycosyl compound metabolic process), GO:0051923 (sulfation), GO:0072521 (purine-containing compound metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0009117 (nucleotide metabolic process), GO:0016137 (glycoside metabolic process), GO:0034310 (primary alcohol catabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0006067 (ethanol metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0034035 (purine ribonucleoside bisphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)