Protein: ATP-dependent 6-phosphofructokinase 7 (ATP-PFK 7) (Phosphofructokinase 7) (EC 2.7.1.11) (Phosphohexokinase 7) (Q9C5J7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03186, ECO:0000269|PubMed:17485088}.
Sequence: MSSPRSNKPKIVNGPGGYILQDVPHLIDYLPDLPTYPNPLQDNPAYSVVKQYFVHADDSVPEKVVVHKDGPRGVHFRRAGPRQKVYFESDEVHACIVTCGGLCPGLNTVIREVVSSLSYMYGVKRILGIDGGYRGFYAKNTIPLNSKVVNDIHKRGGTIIGTSRGGHDTNKIVDSIQDRGINQVYIIGGDGTQRGASVIFEEIRRRRLKVAVVGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESNENGIGFVKLMGRYSGYIAMYATLASRDVDCCLIPESPFYLEGEGGLFEFIERRLKDHGHMVIVLAEGAGQDLMCKSMESTPMDASGNKLLKDVGLWLSQSIKDHFKKNKMVMNLKYIDPTYMIRAVPSNASDNVYCTLLAQSAVHGAMAGYTGYTSGLVNGRQTYIPFYRITETQNNVVITDRMWARLLSSTNQPSFLGPKDTSEEKKELPETPLLDDGAVDIPPVTKEVTK
InterPro domains: - IPR000023: Phosphofructokinase domain (domain) [95-398]
- IPR022953: ATP-dependent 6-phosphofructokinase (family) [96-321]
- IPR012004: Pyrophosphate-dependent phosphofructokinase TP0108-type (family) [4-455]
- IPR050929: Phosphofructokinase type A (family) [5-458]
- IPR035966: Phosphofructokinase superfamily (homologous_superfamily) [26-451]
Interaction partners: - Glucose-6-phosphate isomerase, cytosolic
- Glucose-6-phosphate isomerase 1, chloroplastic
- Aldolase-type TIM barrel family protein
- transaldolase
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
- Mannose-6-phosphate isomerase 1
- Mannose-6-phosphate isomerase 2
- Hexokinase-4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0019200 (carbohydrate kinase activity), GO:0008443 (phosphofructokinase activity), GO:0003872 (6-phosphofructokinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0019637 (organophosphate metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0099402 (plant organ development), GO:1901360 (organic cyclic compound metabolic process), GO:1905392 (plant organ morphogenesis), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0071456 (cellular response to hypoxia), GO:0048364 (root development), GO:0006753 (nucleoside phosphate metabolic process), GO:0071453 (cellular response to oxygen levels), GO:0006757 (ATP generation from ADP), GO:0043436 (oxoacid metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0090627 (plant epidermal cell differentiation), GO:0072521 (purine-containing compound metabolic process), GO:0022622 (root system development), GO:0010015 (root morphogenesis), GO:0019693 (ribose phosphate metabolic process), GO:0036293 (response to decreased oxygen levels), GO:0090558 (plant epidermis development), GO:0016052 (carbohydrate catabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0010053 (root epidermal cell differentiation), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0016310 (phosphorylation), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0036294 (cellular response to decreased oxygen levels), GO:0006163 (purine nucleotide metabolic process), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0046031 (ADP metabolic process), GO:0006090 (pyruvate metabolic process), GO:0046034 (ATP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)