Protein: Actin cytoskeleton-regulatory complex protein PAN1 (Q5AHB1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Localizes at sites of polarized growth like the hyphal tip
Sequence: MYNPYQQQQQGMGYNPQQQTGYGYNNYQMPQQPQFNQQPMYPQATGFVPQQPNLYGSNFQTSGGSGMAPQQTGFSQQQTMQPQQTGYIQTQPTGFGGTAPIVTENSELKIPSIRLSFISAEDQKKFEHLFRTAVPKGEQSISGDSASGILLRSGLSAVTLAEIWNLSDIDKTGSLLFPEFALSLHLCSMAKRGEPLPGILPEKWLNEVRSFVDQINFTVPDDPSKILANTPFANFAPKKESDWLAPQSTGYLQNQSAPPMTSFQPQVTGFGGQGLVSQATGGVPMPSTTFGNAAGLTAQRTGGGTLIPLQPQQTAGLIPAQKTGPLNPQTTGFNQQSLQQQRTGGLPQQLTGYQGPPQGQGQQLQQQRTGGFPQVQSQPTGGFVPQTSFQQPQLVSQRTGPMQAQPTGSLQAQPTGRPGEWGFVSMPTGGIPGLNAMQQHFLPNNQLPTSNLHSAMDNKLKENVTWAITKQEKQIYDGLFQAWDNQKKGYVDSNVALNVFTKSGLSRSDLESIWTLVDTDDTGKLNKNQFAVAMHLIYRRLNGYDIPLRLPPELIPPADRTLKDTMDSLKNSLKGGVNNKPTKPPKPQSKPDGTRFKNDDNNFGYVSNVRHRRKSTSDESHKSSVKSSSDYDLSIEDMKKLIHEKRILLDALDTEDQANNYSRSSSSMHEKQIIENLKKEIMAVQTKLDERGNDGPSSDERNKLLATLDHLTRDVVPRLISDIHKVNQEISRKKAEVFKLELLKKNPSWNPEDDESQIQGTGPNGEVTDYDRIKYQSRQKLKQRMAALTGKSTGGNSDLDLELKQATEKAQDEASRQSEMIQDIAAGIKTMEDECAAKLSSSVTEDVGHEKWEQGKGISSEVAKFVKELEAFSKEQRRNIAKSQKQEQTREPLAKQQTNASLVSDSGAAKSAYATPEERAAYIKQQAEKRMNERLAKLGITRKSKSTEQKPPVESKSVSNHSPVPDSEVKSVTRNANEVEVQKPKPDSQPVSKNREPAEQPNSKADTNSVGSQNVVSNTNDDTSGDDDDEEYKAILKQKQEMEARERERKLRKQKAKEERLAKIKKEMEEMKKREMEESQDEEEEEAKQVTSVHVSRAQSSNANSNVIPQQETATENVNTVSQPTSTDTAKQSYHPHESNPFSKMNNNTSQNSTVTNTGTNPFFKSTSQETKIDPHKAEAQRASQRGVASSGGWSDSEEEESEEESPNRAGAAKLASLLFGGMPQPPTTSSSSLNNDAEKVSEQEHENAKQVASTPLSNDDNGKTDSGPSGFAGENESSFSQAPPIPVDAPPAPNSIPPPPPPPPQFSNEAPPVPDSIPPPPPPPSVPSTVPALPDSMPPPPPPPPPPAAPNNTSSSQQASGAPNIGALLGQITGGASLRKVETKVSSGATVGRVL
InterPro domains: - IPR003124: WH2 domain (domain) [1365-1382]
- IPR000261: EH domain (domain) [115-561]
- IPR011992: EF-hand domain pair (homologous_superfamily) [110-560]
- IPR013182: Domain of unknown function DUF1720 (domain) [17-333]
- IPR002048: EF-hand domain (domain) [159-540]
Interaction partners: - Actin cytoskeleton-regulatory complex protein END3
- Epsin
- Actin-binding protein
- AP-2 complex subunit alpha
- Polyubiquitin
- Actin cytoskeleton-regulatory complex protein SLA1
- Sla2p
- Clathrin heavy chain
- MHD domain-containing protein
- Clathrin light chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0061919 (process utilizing autophagic mechanism), GO:0033036 (macromolecule localization), GO:0009056 (catabolic process), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0045184 (establishment of protein localization), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0016197 (endosomal transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0016482 (cytosolic transport), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0007033 (vacuole organization), GO:0065003 (protein-containing complex assembly), GO:0042147 (retrograde transport, endosome to Golgi), GO:0006623 (protein targeting to vacuole), GO:0045324 (late endosome to vacuole transport), GO:0000045 (autophagosome assembly), GO:0072665 (protein localization to vacuole)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0061645 (endocytic patch), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0030479 (actin cortical patch), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030864 (cortical actin cytoskeleton), GO:0005634 (nucleus), GO:0015629 (actin cytoskeleton)