Protein: Mannose-binding protein (MBP) (Mannan-binding protein) (Q98TA4)
Organism: Gallus gallus (Chicken)
Function: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P19999}.
Sequence: MTLLQPFSALLLCLSLMMATSLLTTDKPEEKMYSCPIIQCSAPAVNGLPGRDGRDGPKGEKGDPGEGLRGLQGLPGKAGPQGLKGEVGPQGEKGQKGERGIAVTDDLHRQITDLEAKIRVLEDDLSRYKKALSLKDFVNVGKKMFVSTGKKYNFEKGKSLCAKAGSVLASPRNEAENTALKDLIDPSSQAYIGISDAQTEGRFMYLSGGPLTYSNWKPGEPNNHKNEDCAVIEDSGKWNDLDCSNSNIFIICEL
InterPro domains: - IPR008160: Collagen triple helix repeat (repeat) [47-100]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [119-254]
- IPR018378: C-type lectin, conserved site (conserved_site) [229-252]
- IPR033990: Collectin, C-type lectin-like domain (domain) [142-254]
- IPR016187: C-type lectin fold (homologous_superfamily) [136-253]
- IPR051077: Calcium-dependent Lectin (family) [1-253]
- IPR001304: C-type lectin-like (domain) [133-253]
Interaction partners: - Uncharacterized protein
- Galectin 3
- Fibrinogen C-terminal domain-containing protein.
- complement subcomponent C1r
- Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Surfactant protein A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0070492 (oligosaccharide binding), GO:0030247 (polysaccharide binding), GO:0048306 (calcium-dependent protein binding), GO:0048029 (monosaccharide binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0042803 (protein homodimerization activity), GO:0005537 (mannose binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0044403 (biological process involved in symbiotic interaction), GO:0051050 (positive regulation of transport), GO:0051707 (response to other organism), GO:0051049 (regulation of transport), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0051702 (biological process involved in interaction with symbiont), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0050766 (positive regulation of phagocytosis), GO:0006952 (defense response), GO:0050778 (positive regulation of immune response), GO:0060627 (regulation of vesicle-mediated transport), GO:0006956 (complement activation), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0050764 (regulation of phagocytosis), GO:0042742 (defense response to bacterium), GO:0051873 (killing by host of symbiont cells), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)