Protein: Ras-related protein Rab-25 (F1Q9W8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB25 regulates epithelial cell differentiation, proliferation and survival, thereby playing key roles in tumorigenesis. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis
Subcellular location: Cell projection, pseudopodium membrane. Endomembrane system; Lipid-anchor
Sequence: MGSDEAYNFVFKVVLIGESGVGKSNLLSRFTKNEFSHDSRTTIGVEFSTRTVQLNGLTIKAQIWDTAGLERYRAITSAYYRGAVGALLVYDISKHLTYESAERWLKELYDHADPHIVVMLVGNKSDLAAVRSVPTEDAKDFAEKNGLLFMETSALESVNVEAAFNTVLTEIHKKVNSKEVTRGSISAVTLSQPKTPAETQEEKKTCCKNL
InterPro domains: - IPR050209: Rab GTPases family involved in membrane trafficking (family) [7-192]
- IPR001806: Small GTPase (family) [5-210]
- IPR005225: Small GTP-binding domain (domain) [11-168]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4-207]
Interaction partners: - Cytochrome P450 2F2-like
- Cytochrome P450 2X10.2 isoform 2
- ADP-ribosylation factor-like 4Ca
- Organic solute transporter subunit alpha
- Phosphatidylinositol 4-kinase beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0033059 (cellular pigmentation), GO:0051234 (establishment of localization), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051640 (organelle localization), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0051875 (pigment granule localization), GO:0001568 (blood vessel development), GO:0051656 (establishment of organelle localization), GO:0048731 (system development), GO:0006810 (transport), GO:0070121 (Kupffer's vesicle development), GO:0051649 (establishment of localization in cell), GO:0051648 (vesicle localization), GO:0035239 (tube morphogenesis), GO:0051904 (pigment granule transport), GO:0051905 (establishment of pigment granule localization), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0032400 (melanosome localization), GO:0051650 (establishment of vesicle localization), GO:0032402 (melanosome transport), GO:0032401 (establishment of melanosome localization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0055037 (recycling endosome), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)