Protein: Large ribosomal subunit protein P2C (O14317)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel
Subcellular location: Cytoplasm
Sequence: MKYLAAYLLLTVGGKNSPSASDIESVLSTVGIESESERVEALIKELDGKDIDELIAAGNEKLATVPSGGAAAAAAPAAAGGAAPAAEEAAKEEAKEEEESDEDMGFGLFD
InterPro domains: - IPR027534: Large ribosomal subunit protein P1/P2 (family) [2-110]
- IPR044076: Large ribosomal subunit protein P2, eukaryota (family) [1-110]
- IPR038716: Large ribosomal subunit protein P1/P2, N-terminal domain (homologous_superfamily) [1-59]
- IPR001859: Large ribosomal subunit protein P1/P2, eukaryota (family) [21-108]
Interaction partners: - Large ribosomal subunit protein uL10
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL28
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL29
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)