Protein: Dystrophin-1 (Q9TW65)
Organism: Caenorhabditis elegans
Function: Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Sequence: MLFSGASTAKPKKDEKKDKKSDRDPKNELQEWVFVRWANHLLGTERLTDYKSLQDGSNAIFVYQAIIGQTMAVLGNPSDDWPNVLQNIGDSKTNPQEVMEGQQKAVLSAWWQLVQFFWKNNAPVQLREEKLSEAIKQWCIEVMKSYEEIDVYDFTSSFRDGHAFNYLIHSYDRKLINLTKTAEMSAIDRIENAFAVAEKTWNVPRLLNPKDLHSDQLDSHSVLCYLMSLYLAMISTSKIETELEAQQIQQQKVAALLASHKMLSSQPSTSSSSALQIPPQTPPTAHHQAMLDRGKSFEQSAEGEVRSRKSSSSSQKSGKSKKARREEQLAEFKSCIEQVLTWLLEAEDELTTLTQMPRVELASVRSQFSDFESFMSSLTDSQDTVGRVLLRGQMLSNKSESEEEKESIGANLHLVNTRWEALREQAMQEQAVLQQQIHLLQQSELDTISQWLDAAELEIESFGPLAADSSQALRQIELHTKFQQKLNDFQETIDKLESFVAVVDEENDASVATLEDALSAVSVRWGHVCEWAEKRATKLDGLADLLDKTNEVFENLSGWLAERENELMTGLKSAHHLENEEQVAQQVRRLQKTEEQLEQEHASFVRLSQLSCELVGRLDDSNGAAANAVRLSLDSITQRWDNLVARIEEHGKTLVKSGKADVKQVQESQNEQKEQPASSEGLSTDTEGEEQKNQLVDKFLLHISKLSHELEPLQDWSEKFEVSRKKDDIRKMMNTCQEKLIQIKEQEARVNRLQLELEHLHVAKLNARQLKRANDAFEQFAKGWARIVTKISEAMNVLTGQEAGGNGNGSEEAAVAAKIEQWIEAVDKVINELSQLPVNERRSRIDKLEQQLQVQDKNVGFIEKDLLKKAILKKGLEIAGKRLAALKVEEKPVEKEEQLVLSNSEEPEAEKHVTFVQETTEKPAPLQEPTSEAQLLEELDGPWSRVGDVVAIEHDLLRAKRAVDTARNSQMSNETVEKAETRKAEMEEKRRVTMSARSKFRMAEETLEEIERNLDRLQVSDLEIADLVRGLEQEAAKLGERVSQRKEAERTAEKILSMDDDEISQEIVIKTKDSTEKLIKRWNQLELDLEENLRKAKRDQDVFIQKRLREGEEALNEIKTAIEGKRESLDAETAAENLDHLESSLDNISSLFGEIGSLPMDDNSREKLSKLAKAKDQITARANEALAALTRTVSECEDFEKQIMLFQNWSARIGFLLQARKSADISAFDIPHEYHEDLGNEAELIPKLSREFEEWTVKLNEMNSTATEKDDSARMREQLNHANETMAELKRKFNEFKRPKGFEEKLEKVITTLSNVEMGLDDTTGIDGSECGGALMEVRALVRMLDGAQEKWKDLAENREQLVKDRVLDEETSKETLQKLQYAKTKSKELYERSSTCIERLEDCVEMYQRLKMESDEIERFLEEMEGKLDQYAASDRPEEAEIVNELISEWNRNEAAMKNAEHLQRQLNERAIKIPDDVLSLKRLRADALKNRLNSWCRTIQEMSEDDESALLEIDELHQNLEKELKLVSDKEPSKIAEKLRFLRADRDRLSSRTRKLAAKNPRLAATSSDVLAGLNQKWKELEVKASAEKAPAPELRDARLSSPSEQPFDKRVQELCDLFENLEAQLDFNGSPVSMVTEYQKRVENLDEYLDEYRPALDDTIEEGRKIAETGRLELQTHSAIEKLDELTNRIEQVEVELDKHRDKVPSLVEQHEQLKKDIDSFLLVLDVFTDRNLDDVDIAKSTRKELAERDSHIVSLTSRATAIHCALPGKGPQLHDVTLDKLRDRIEKLEARLSATEKKPVETVKSTIPDRPEVPEEPEKSSPDRTSRSSLQLAMEAYGTATEDDSVISEAVTVGQKSVDQVDPVEQLEPVEPVEPKLEVKQLKDEATEEEEKRTIILPDETEKVIETIPAARPSAGPSEGTVAEVSTSEILKARPAQESIERTVREVPVDEYEETANISSGDELQDHKISSAVPDSESEIASMFEVLDSIEDSHTNFEEFPFDYLDSADDDLKKTLLKLESCEKTLAKNEMTINIAQAENARERITMLRQMALQRKDKLPKFNEEWNAMQELIQLADALVDEAERYESDQIPQMDRKSAPNVLGELRKRVANAEGPVIDLVKKLSQLVPRMQEDSPKSQDIRQKVYGIEDRFRRVGQAEGAAISKALSSALTEPELKLELDEVVRWCEMAEKEAAQNVNSLDGDGLEKLDGRLAQFTKELQERKDDMVQLEMAKNMIIPSLKGDAHHDLRRNFSDTAKRVAMVRDELSDAHKWVATSRDTCDTFWADIDSLEQLARDVVRRANGIRMAVIYTPSRENVEGVLRDVQRLKMSIGDVKKRVQTANLPPAIKLAGKNAKRVVQVLTETATTIADCHDIPTYLIDEMNDSGGDTTESRSTVVEMTSVHTKQSSSSSSNKTPSAGGESDDAHTLNGDDEQSEEDQKIYSRESSSTLPRGVSSLGSTGSSGVLDPVAVQLTHTRHWLHDVERDASITVDLAQWQPARELWQSIQGIIDEIRLRSVHVTGAHDASPNRQVRQQAAQLLTEMRRTIENCEKRCLILNQISDIARQNEASRNEMELWLKSASDVIGERRVEELSEEVVRQELQVLERVVEQLTERKDKMAEINSQANKIVDTYTKDEAHNLSHLLSRLNMSWTKFNDNIRIRRAVLEASLRSRRDFHSALSEFEKWLSRQEDNCSKLSADTSNHQAIKDTSKRKNWTQSFKTLNAELNAHEDVMKSVEKMGKMLAESLESGNEKVELLKRVGETTRRWTALRKTTNEIGERLEKAEQEWEKLSDGLADLLSWVEAKKQAIMDEQPTGGSLSAVMQQASFVKGLQREIESKTANYKSTVEEAHSFLMQHDLRPKLHSPHVLDDDYEKEELANLEQRRRGLEINANCERLKKNWAELGIEVESWDKLVQHAMQRLQELERNLAECQLHLTSSENEIETMKAVEKIHLEDLKIAREETDQISKRIDEVRLFVDDVNDAAARLLAEDLKLDEHAKGQIEHVNKRYSTLKRAIRIRQAAVRNAASDFGPTSEHFLNQSVTLPWQRAISKSNLLPYYIEQTSEKTQWEHPVWVEIVKELSQFNRVKFLAYRTAMKLRALQKRLCLDLVDLTLLEKAFVRLKGLSAEECPGLEGMVCALLPMYEALHAKYPNQVQSVSLAVDICINFLLNLFDQSRDGIMRVLSFKIAMIVFSNIPLEEKYRYLFKLVSQDGHATQKQIALLLYDLIHIPRLVGESAAFGGTNVEPSVRSCFETVRLAPTISEGAFIDWVKKEPQSIVWLAVMHRLVISESTKHASKCNVCKMFPIIGIRYRCLTCFNCDLCQNCFFSQRTAKSHRTNHPMQEYCEKTTSSDDARDFAKMIRNKFRASKRQKGYLPIDVAEEGIPLTCPPAKVTNQATEQMNADTSQMTAHLAKLSAEHGGGAEHMEPVQSPLQIINQVEQLQRDEMDQMLHRLQFENKQLRKELEWKRGAASTMEIDRSSKRHQERHQSESRGGTLPLRNGRSVVSLKSTQSQNDVMDEAKALRLHKQRLEHRSRILEQQNEQLEMQLQRLKKVIDAQKQQAPLSTNSLLRGSHHQPWSPERARSGSASTLDRGLIVSSRHQEQAEAAGGGAEDSSDEAGGAGGGPRGSSVGQMQNLMTACDDLGKAMESLVVSVVYDSDDEEND
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [18-237]
- IPR001202: WW domain (domain) [3047-3081]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [30-39]
- IPR050774: KCMF1 and Dystrophin (family) [2773-3658]
- IPR000433: Zinc finger, ZZ-type (domain) [3300-3357]
- IPR013087: Zinc finger C2H2-type (domain) [3327-3347]
- IPR056503: Dystrophin-1-like, spectrin repeat domain (domain) [2477-2564]
- IPR002017: Spectrin repeat (repeat) [328-539]
- IPR018159: Spectrin/alpha-actinin (repeat) [328-2915]
- IPR011992: EF-hand domain pair (homologous_superfamily) [3078-3298]
- IPR043145: Zinc finger, ZZ-type superfamily (homologous_superfamily) [3295-3355]
- IPR015153: EF-hand domain, type 1 (domain) [3083-3201]
- IPR015154: EF-hand domain, type 2 (domain) [3205-3294]
- IPR036020: WW domain superfamily (homologous_superfamily) [3039-3077]
- IPR001715: Calponin homology domain (domain) [129-234]
Interaction partners: - Syntrophin-1
- Dystrobrevin-1
- Dystrophin-like protein 1
- PDZ domain-containing protein
- Alpha-catulin
- Dystroglycan-type cadherin-like domain-containing protein
- Dystroglycan 1
- Sarcoglycan complex subunit protein
- Tropomyosin isoforms a/b/d/f
- Beta-sarcoglycan
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0016043 (cellular component organization), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0022607 (cellular component assembly), GO:0042692 (muscle cell differentiation), GO:0006996 (organelle organization), GO:0031032 (actomyosin structure organization), GO:0030239 (myofibril assembly), GO:0055001 (muscle cell development), GO:0097435 (supramolecular fiber organization), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0051146 (striated muscle cell differentiation), GO:0055002 (striated muscle cell development), GO:0045214 (sarcomere organization), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0040017 (positive regulation of locomotion), GO:0040012 (regulation of locomotion), GO:0030866 (cortical actin cytoskeleton organization), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030424 (axon)