Protein: Proteasome subunit alpha type (Q38B02)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Sequence: MFKNQYDTDTTTWSPTGRLFQVEYANEAVNNGSAAVGVKGADYVVLTALKRNPVSGLSSYQEKAFKLDEHVGMAISGLVADGRALSRFLRTECMNYRYMHDSDAPLVMLADMVGAKHQRHIQFAGKRPFGVGLLIAGYDRQGPRLYQTVPSGDVFDFKATAMGLRSQAARTYLERHFRGFPACDLDELVMHALRALGAATSGGVELNIKNTTIAIVGKGTPFTILTEEEARKYLDGFKTRPEDIPAVADNEEDDDELHEQPPDVEE
InterPro domains: - IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [4-240]
- IPR035144: Proteasome subunit alpha 1 (family) [6-217]
- IPR001353: Proteasome, subunit alpha/beta (family) [29-216]
- IPR050115: Proteasome subunit alpha (family) [10-234]
- IPR000426: Proteasome alpha-subunit, N-terminal domain (domain) [6-28]
- IPR023332: Proteasome alpha-type subunit (family) [21-234]
Interaction partners: - Proteasome subunit beta
- Proteasome regulatory non-ATPase subunit 8
- Proteasome regulatory ATPase subunit 5
- Proteasome subunit beta
- Probable 26S proteasome regulatory subunit rpn-6.2
- 26S proteasome regulatory non-ATPase subunit
- Proteasome subunit alpha type
- Proteasome regulatory non-ATP-ase subunit 5
- Proteasome regulatory non-ATP-ase subunit
- Proteasome subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:0043233 (organelle lumen), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:1905369 (endopeptidase complex), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)