Protein: Spectrin beta chain (F6W8M4)
Organism: Macaca mulatta (Rhesus macaque)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MSSTLSPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGETLPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGKHLTGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGVLRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPALSRTPEVQGRVPTLERHYEELQARAGKRARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDVAEQLLKASPPGKDRIVNTQEQLNHRWQQFRSLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIASRVGELTREANALAAGHPAQAAAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHRKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLGDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMQERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAQLQEMWKRLGHELELRGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSAQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVGGQTAPDTTWDRTQLRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEDSSSPEGPGPGPGDEANGPRGDRQTRTRGAAPPAMPQSRSTESAHAATLPPRGPEPSAQEQMEGVLCRKQEMEAFGKKAANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKLGLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGAEGPVVLRSKDGREREREKRFSFFKKNK
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [17-286]
- IPR001849: Pleckstrin homology domain (domain) [2218-2330]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [59-157]
- IPR016343: Spectrin, beta subunit (family) [2-2390]
- IPR018159: Spectrin/alpha-actinin (repeat) [306-2256]
- IPR001605: Pleckstrin homology domain, spectrin-type (domain) [2221-2321]
- IPR041681: Pleckstrin homology domain 9 (domain) [2222-2327]
- IPR002017: Spectrin repeat (repeat) [306-2076]
- IPR001715: Calponin homology domain (domain) [57-281]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [2214-2334]
Interaction partners: - Metabotropic glutamate receptor 1
- Spectrin alpha chain, erythrocytic 1
- Spectrin alpha chain, non-erythrocytic 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005200 (structural constituent of cytoskeleton)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0035264 (multicellular organism growth), GO:0071840 (cellular component organization or biogenesis), GO:0007610 (behavior), GO:0021549 (cerebellum development), GO:0021575 (hindbrain morphogenesis), GO:0044085 (cellular component biogenesis), GO:0021696 (cerebellar cortex morphogenesis), GO:0060322 (head development), GO:0021692 (cerebellar Purkinje cell layer morphogenesis), GO:0021680 (cerebellar Purkinje cell layer development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0021695 (cerebellar cortex development), GO:0016043 (cellular component organization), GO:0030534 (adult behavior), GO:0021587 (cerebellum morphogenesis), GO:0051128 (regulation of cellular component organization), GO:0022037 (metencephalon development), GO:0044087 (regulation of cellular component biogenesis), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0033043 (regulation of organelle organization), GO:0007417 (central nervous system development), GO:0099173 (postsynapse organization), GO:0034330 (cell junction organization), GO:1902115 (regulation of organelle assembly), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0099150 (regulation of postsynaptic specialization assembly), GO:0050808 (synapse organization), GO:0034329 (cell junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0043025 (neuronal cell body), GO:0005886 (plasma membrane), GO:0099571 (postsynaptic cytoskeleton), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0070161 (anchoring junction), GO:0016324 (apical plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0060076 (excitatory synapse), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0098978 (glutamatergic synapse), GO:0005856 (cytoskeleton), GO:0098688 (parallel fiber to Purkinje cell synapse)