Protein: Glutamate receptor (F1R366)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Postsynaptic density membrane
Sequence: MRLLLLAALFSCSCVRGGCEPKIVNIGAVLSQKRYEQVFKDAVTQANQVYGRDKFKLTAISVTHKANAIQMALSVCEDLISSQVYAILVSHPPQSNDHLTPTPVSYTAGFYRIPVVGLTTRMSIYSDKSIHLSFLRTVPPYSHQAHVWFDMMREFRWNHIILIVSDDHEGRAAQKRLETLLEERETKNKKRNYENQDQLSYDNKRGPKAEKVLQFNQETNLTALLLEAKELEARVIILSASEEDAAAVYKTARFLNMTGSGYVWLVGEREMSGKALSEAPDGLIGLQLINGKNESAHISDAVAVVAQSIQELFEKENITEPPRGCVGNTNIWKTGPLFKRVLMSSKYPEGLTGRVEFNDDGDRKYAHYSILNYQKSRLIQVGIYNGTQVVMNKQRKIIWPGGETERPRGFQMSTRLKIVTIHQEPFVYVKPTTLEGTCKEEYTPNGVLIKKVICTGPNETIPGRPIVPQCCYGFCIDLLIKLALTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLGGLADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLAILSSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIAAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQQYPPTDITGQLNLSDPSVSTVV
InterPro domains: - IPR001508: Ionotropic glutamate receptor, metazoa (family) [488-853]
- IPR049872: Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain (domain) [413-815]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [457-561]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [451-840]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [18-409]
- IPR015683: Ionotropic glutamate receptor (family) [25-860]
- IPR001828: Receptor, ligand binding region (domain) [39-375]
- IPR049873: Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domain (domain) [22-401]
Interaction partners: - Glutamate receptor
- Glutamate receptor
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor
- Glutamate receptor
- Calcium channel, voltage-dependent, gamma subunit 4a
- Calcium channel, voltage-dependent, gamma subunit 8a
- Metabotropic glutamate receptor 5
- Glutamate receptor
- Voltage-dependent calcium channel gamma-7 subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0008066 (glutamate receptor activity), GO:0004972 (NMDA glutamate receptor activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0004970 (ionotropic glutamate receptor activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0010043 (response to zinc ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0098878 (neurotransmitter receptor complex), GO:0034702 (ion channel complex), GO:0008328 (ionotropic glutamate receptor complex)