wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Battenin (Q5U392)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Sequence: MDRSVNSGTASTSDTEGRCQRWRNCVAFWLLGLCNNFAYVVMLSAAHDILQKQESQNTTAPSPAPNGTNIEFRNSSNSSRYDCNPVSTAAVLLADILPTLLIKLTAPFYIHKVPYGFRVLVCFFTAVVSFLMVSFSSTISMSIIGVIFASVSSGLGELSFLSLSVFFSSDVLSGWGSGTGAAGVAGALLYSALTQAGLTPQVTLWIMLVVPVILAVSYFVLLVFPHSFPQWRCPEVSQSLSRGLNSEERRALIEEDTDTDEDSEPALEDQDDKHIGPLTFTEKKYIIKGLLKFIFPLALVYFAEYFINQGLMELLYFPDSRLSHAEQYRWYQTVYQIGVFVSRTSLFCFKIRKIFLMSLLQCANAVLLVFAVYYQFLPNISVVFVIIAFEGLLGGAAYVNTFFFIREESVEREREFAMATATVGDSLGIAFSAAAAFPVHHYFCSL
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [17-444]
- IPR018460: Batten's disease protein Cln3, subgroup (family) [11-446]
- IPR003492: Batten's disease protein Cln3 (family) [19-445]
Interaction partners: - Uncharacterized protein.
- CLN6 transmembrane ER protein a.
- Major facilitator superfamily domain-containing protein 8
- Palmitoyl-protein thioesterase 1
- 3-hydroxy-3-methylglutaryl-CoA lyase.
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Tripeptidyl-peptidase 1
- Cathepsin D
- Cathepsin F
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0003008 (system process), GO:0050794 (regulation of cellular process), GO:0032101 (regulation of response to external stimulus), GO:0050877 (nervous system process), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0007600 (sensory perception), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0043410 (positive regulation of MAPK cascade), GO:0007601 (visual perception)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Glucan endo-1,3-beta-glucosidase 4 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase 4) ((1->3)-beta-glucanase 4) (Beta-1,3-endoglucanase 4) (Beta-1,3-glucanase 4) (Q94CD8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Sequence: MLLPRWFAEALLLLLSILACSNAAFIGVNIGTDLTNMPPPSDIVTLLKSQQITHVRLYDANSHMLKAFANTSIEVMVGVTNEEILKIGRFPSAAAAWVNKNVAAYIPSTNITAIAVGSEVLTTIPHVAPILASALNNIHKALVASNLNFKVKVSSPMSMDIMPKPFPPSTSTFSPSWNTTVYQLLQFLKNTGSFFMLNAYPYYGYTTANGIFPLDYALFKQLSPVKQIVDPNTLLHYNSMFDAMVDAAYYSMEALNFSKIPVVVTETGWPSSGGSDEAAATVANAETFNTNLIKRVLNNSGPPSQPDIPINTYIYELYNEDKRSGPVSERNWGILFPNGTSVYPLSLSGGSSSAALNGSSMFCVAKADADDDKLVDGLNWACGQGRANCAAIQPGQPCYLPNDVKSHASFAFNDYYQKMKSAGGTCDFDGTAITTTRDPSYRTCAYTGSLNANATNGNFPPDALGPASPLGGNANARIIFSYHLPILAPLALTLLQLLLQHDRLL
InterPro domains: - IPR000490: Glycoside hydrolase family 17 (family) [26-345]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [26-346]
- IPR044965: Glycoside hydrolase family 17, plant (family) [16-435]
- IPR012946: X8 domain (domain) [361-446]
Interaction partners: - Non-structural maintenance of chromosomes element 1 homolog
- alpha-D-xyloside xylohydrolase
- Structural maintenance of chromosomes protein 5
- E3 SUMO-protein ligase MMS21
- Beta-glucosidase 31
- Non-structural maintenance of chromosomes element 4 homolog B
- Non-structural maintenance of chromosomes element 4 homolog A
- Structural maintenance of chromosomes protein 6A
- Structural maintenance of chromosomes protein 6B
- Probable pectate lyase 12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0003676 (nucleic acid binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0003677 (DNA binding), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0050832 (defense response to fungus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Phosducin-like protein (PHLP) (Q9DBX2)
Organism: Mus musculus (Mouse)
Function: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:29290584}.
Sequence: MTTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPAISSTPAEAELAGEGISINTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKEFGTKDKNLDDEEFLQQYRKQRMEEMRQQFHKGPQFKQVFEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLATEYPAVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [56-276]
- IPR023196: Phosducin, N-terminal domain superfamily (homologous_superfamily) [51-143]
- IPR051499: Phosducin-like regulator (family) [1-300]
- IPR024253: Phosducin, thioredoxin-like domain (domain) [36-299]
- IPR001200: Phosducin (family) [47-272]
Interaction partners: - Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- T-complex protein 1 subunit eta
- Guanine nucleotide-binding protein G
- T-complex protein 1 subunit epsilon
- Guanine nucleotide-binding protein G
- T-complex protein 1 subunit gamma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0008277 (regulation of G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: S-adenosylmethionine synthase (EC 2.5.1.6) (Q586G3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSVRQIFFTSEHVSEGHPDKLCDQVSDAVLDACLEQDPLSKVACETCSKTGMVLVFGEITTKAVIDYQKVVRDTVKEIGFDNTEKGLDYRSLNLLVAVEQQSPDIYQGLGDFGGENLGAGDQGMMFGYATNETETLMPLSYELARGLAMTYSELRRNGGLPWARPDAKTQVTVQYEYDTRGGKQLLTPKRVAVILVSAQHDDGVSNETIREDLVKKVISTTIPAKFLDENTKYHLNPSGRFVIGGPHGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSLVAAGLADRCLVQLSYAIGVAEPLNIHVDTYGTGKRDDEYILGIVQKNFRLRPYDIIKELDLRRPIYRQTACFGHFGRVDTNGKGGFTWEVPKTLEGLSDVQ
InterPro domains: - IPR002133: S-adenosylmethionine synthetase (family) [1-397]
- IPR022631: S-adenosylmethionine synthetase, conserved site (conserved_site) [118-277]
- IPR022636: S-adenosylmethionine synthetase superfamily (homologous_superfamily) [5-393]
- IPR022628: S-adenosylmethionine synthetase, N-terminal (domain) [6-103]
- IPR022630: S-adenosylmethionine synthetase, C-terminal (domain) [243-375]
- IPR022629: S-adenosylmethionine synthetase, central domain (domain) [117-241]
Interaction partners: - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- S-adenosylmethionine decarboxylase proenzyme-like, putative
- S-adenosylmethionine decarboxylase proenzyme
- Homocysteine S-methyltransferase, putative
- DNA
- S-adenosylmethionine synthase
- S-adenosylmethionine synthase
- NAD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0046500 (S-adenosylmethionine metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006790 (sulfur compound metabolic process), GO:0044272 (sulfur compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0097014 (ciliary plasm)
Protein: ATPase inhibitor mai-1, mitochondrial (ATP synthase F1 subunit epsilon) (P37209)
Organism: Caenorhabditis elegans
Function: Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.
Subcellular location: Mitochondrion {ECO:0000305}.
Sequence: MSGSGSGSGAGHGGGSGGSIREAGGSLGMMGATREEEYFRRQQKDQLDNLKKKLEADMTQSQQEIRDHEKVLEQHQQRLKEIEKGHGT
InterPro domains: - IPR007648: Mitochondrial ATPase inhibitor (family) [6-73]
Interaction partners: - Nuclear Hormone Receptor family
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0060590 (ATPase regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0042030 (ATPase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009892 (negative regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0062014 (negative regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0044092 (negative regulation of molecular function), GO:0043462 (regulation of ATP-dependent activity), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006140 (regulation of nucleotide metabolic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0032780 (negative regulation of ATP-dependent activity), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0045980 (negative regulation of nucleotide metabolic process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Jupiter microtubule associated homolog 1 (J3KT51)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKVSVTA
InterPro domains: - IPR033335: Microtubule-associated protein Jupiter (family) [1-101]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0044093 (positive regulation of molecular function), GO:0031325 (positive regulation of cellular metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0043549 (regulation of kinase activity), GO:0051347 (positive regulation of transferase activity), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0042327 (positive regulation of phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Ephrin-A3 (EFL-2) (EHK1 ligand) (EHK1-L) (EPH-related receptor tyrosine kinase ligand 3) (LERK-3) (P52797)
Organism: Homo sapiens (Human)
Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Sequence: MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNASQGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS
InterPro domains: - IPR031328: Ephrin (family) [13-179]
- IPR001799: Ephrin receptor-binding domain (domain) [30-169]
- IPR008972: Cupredoxin (homologous_superfamily) [28-177]
- IPR034252: Ephrin-A ectodomain (domain) [31-166]
- IPR019765: Ephrin, conserved site (conserved_site) [121-148]
Interaction partners: - Ephrin type-A receptor 1
- Ephrin type-A receptor 4
- Ephrin type-A receptor 2
- Ephrin type-A receptor 3
- Ephrin type-A receptor 5
- Ephrin type-A receptor 10
- Ephrin type-A receptor 7
- Ephrin type-A receptor 8
- Ras GTPase-activating protein 1
- Tyrosine-protein kinase Fyn
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046875 (ephrin receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007154 (cell communication), GO:0007267 (cell-cell signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Isoflavone reductase homolog P3 (EC 1.3.1.-) (P52577)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MATEKSKILVIGGTGYIGKFLVEASAKAGHSTFALVREATLSDPVKGKTVQSFKDLGVTILHGDLNDHESLVKAIKQVDVVISTVGSMQILDQTKIISAIKEAGNVKRFLPSEFGVDVDRTSAVEPAKSAFAGKIQIRRTIEAEGIPYTYAVTGCFGGYYLPTLVQFEPGLTSPPRDKVTILGDGNAKAVINKEEDIAAYTIKAVDDPRTLNKILYIKPSNNTLSMNEIVTLWEKKIGKSLEKTHLPEEQLLKSIQESPIPINVVLSINHAVFVNGDTNISIEPSFGVEASELYPDVKYTSVDEYLSYFA
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [5-273]
- IPR050608: NmrA-type oxidoreductase, Isoflavone reductase subfamily (family) [4-308]
- IPR008030: NmrA-like domain (domain) [4-306]
- IPR045312: Phenylcoumaran benzylic ether reductase-like (domain) [7-305]
Interaction partners: - RING-H2 finger protein ATL48
- Small ribosomal subunit protein uS19y
- Probable quinone oxidoreductase
- Methionine aminopeptidase 1A
- non-specific serine/threonine protein kinase
- Large ribosomal subunit protein uL11x
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0050664 (oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009698 (phenylpropanoid metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009806 (lignan metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009699 (phenylpropanoid biosynthetic process), GO:0009807 (lignan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II) (P20231)
Organism: Homo sapiens (Human)
Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.
Subcellular location: Secreted. Note=Released from the secretory granules upon mast cell activation.
Sequence: MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [60-229]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [31-267]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [70-75]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [218-229]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [3-271]
- IPR001254: Serine proteases, trypsin domain (domain) [30-272]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0017171 (serine hydrolase activity), GO:0042802 (identical protein binding), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006952 (defense response), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045229 (external encapsulating structure organization), GO:0006508 (proteolysis), GO:0043062 (extracellular structure organization), GO:0022411 (cellular component disassembly), GO:0022617 (extracellular matrix disassembly), GO:0030198 (extracellular matrix organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0030312 (external encapsulating structure), GO:0005615 (extracellular space), GO:1905368 (peptidase complex), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)