Protein: FHA domain-containing protein FHA2 (Protein FORKHEAD-ASSOCIATED DOMAIN 2) (AtFHA2) (Q9SFV2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in the control of plant organ development and specifically in the regulation of stamen development. Does not show transactivation activity in yeast.
Subcellular location: Nucleus {ECO:0000269|PubMed:23192389, ECO:0000269|Ref.4}. Note=Detected at discrete loci in the nucleus. {ECO:0000269|PubMed:23192389}.
Sequence: MATAVGGGSDVEVGFAKLQGEDFEYYMQSYSIILGRNSKKATVDVDLSSLGGGMNISRNHARIFYDFTRRRFSLEVLGKNGCLVEGVLHLPGNPNVKLDSQDLLQIGDKEFYFLLPVRSILGGPLGPRHHVSGQTSVVPYHNYQSGPGSGSGKKGVRSRELYEYDDEDDDDDDDEEDDMRGSGKKTRRDGHEVVYASGEKKREGRSKVDREADDQQFLQLEEKDVVSSVATVLSDLCGPGEWMPMEKLHSVILKEYGNVWHHSRVRRYLSQEDWAIPEAKGKPWYGLLMLLRKYPEHFVINTRSKGRVTLEFVSLVTLLS
InterPro domains: - IPR000253: Forkhead-associated (FHA) domain (domain) [31-107]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [18-118]
- IPR045178: Transcription regulator Fhl1/FHA1 (family) [10-169]
Interaction partners: - Homeobox-DDT domain protein RLT2
- Homeobox-DDT domain protein RLT1
- FHA domain-containing protein At4g14490
- DEAD-box ATP-dependent RNA helicase 27
- Transcriptional repressor ILP1
- Small RNA degrading nuclease 1
- WD-40 repeat-containing protein MSI3
- Zinc-finger domain of monoamine-oxidase A repressor R1 protein
- DDT domain-containing protein DDR4
- Transcription factor bHLH140
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051053 (negative regulation of DNA metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0000018 (regulation of DNA recombination), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0008156 (negative regulation of DNA replication), GO:0090329 (regulation of DNA-templated DNA replication), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0046777 (protein autophosphorylation), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)