Protein: Cadaverine/lysine antiporter (P0AAE8)
Organism: Escherichia coli (strain K12)
Function: Under acidic conditions, in the presence of lysine, functions as a cadaverine:lysine antiporter that facilitates the excretion of cadaverine and the uptake of lysine. At neutral pH, also catalyzes the uptake of cadaverine via a proton symport mechanism, however the physiological relevance of this uptake activity is probably negligible because the expression of cadB is low at neutral pH. Cadaverine uptake activity is low at acidic pH.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:16877381}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVPAGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAIVGWHWFDAATYAANWNTADTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQVLSGMYPSSVMAASGAPFAISASTILGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDSNGIPKKGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGVNIRNFVSLICSVLGCVFCFIALMGASSFELAGTFIVSLIILMFYARKMHERQSHSMDNHTASNAH
InterPro domains: - IPR050367: Amino acid-polyamine-organocation superfamily (family) [3-428]
- IPR002293: Amino acid/polyamine transporter I (family) [7-417]
- IPR004754: Amino acid antiporter (family) [2-443]
Interaction partners: - Inducible lysine decarboxylase
- Transcriptional activator CadC
- Inducible ornithine decarboxylase
- Constitutive lysine decarboxylase
- Glutamate decarboxylase alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0015101 (organic cation transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015203 (polyamine transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015293 (symporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0071941 (nitrogen cycle metabolic process), GO:0043605 (amide catabolic process), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0044270 (cellular nitrogen compound catabolic process), GO:0071705 (nitrogen compound transport), GO:1901565 (organonitrogen compound catabolic process), GO:0072521 (purine-containing compound metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0003333 (amino acid transmembrane transport), GO:0072337 (modified amino acid transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015807 (L-amino acid transport), GO:1902475 (L-alpha-amino acid transmembrane transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)