Protein: GDNF family receptor alpha-3 (GDNF receptor alpha-3) (GDNFR-alpha-3) (GFR-alpha-3) (O60609)
Organism: Homo sapiens (Human)
Function: Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9576965}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:9576965}.
Sequence: MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFSCTLPLILLLSLW
InterPro domains: - IPR037193: GDNF receptor alpha (homologous_superfamily) [246-347]
- IPR016017: GDNF/GAS1 (domain) [44-340]
- IPR003505: Glial cell line-derived neurotrophic factor receptor, alpha 3 (family) [9-360]
- IPR003438: Glial cell line-derived neurotrophic factor receptor (family) [35-352]
Interaction partners: - Artemin
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Persephin
- Neurturin
- Glial cell line-derived neurotrophic factor
- GDNF family receptor alpha-1
- High affinity nerve growth factor receptor
- GDNF family receptor alpha-4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0015026 (coreceptor activity), GO:0008046 (axon guidance receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0048485 (sympathetic nervous system development), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0001764 (neuron migration), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048483 (autonomic nervous system development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)