Protein: Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (mISK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) (MinK) (P23299)
Organism: Mus musculus (Mouse)
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15382}. Apical cell membrane {ECO:0000250|UniProtKB:P15383}. Membrane raft {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (By similarity). {ECO:0000250|UniProtKB:P15382, ECO:0000250|UniProtKB:P15383}.
Sequence: MSLPNSTTVLPFLARLWQETAEQGGNVSGLARKSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKAVFQARVLESFRACYVIENQAAVEQPATHLPELKPLS
InterPro domains: - IPR005424: Potassium voltage-gated channel subfamily E member 1 (family) [9-125]
- IPR000369: Potassium channel, voltage-dependent, beta subunit, KCNE (family) [1-128]
Interaction partners: - Potassium voltage-gated channel subfamily KQT member 1
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- Potassium voltage-gated channel subfamily E member 3
- Voltage-gated inwardly rectifying potassium channel KCNH2
- Sodium channel protein type 5 subunit alpha
- A-type voltage-gated potassium channel KCND2
- Potassium voltage-gated channel subfamily E regulatory beta subunit 5
- Potassium voltage-gated channel subfamily E member 4
- Potassium voltage-gated channel subfamily KQT member 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0060306 (regulation of membrane repolarization), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0051606 (detection of stimulus), GO:0140352 (export from cell), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009581 (detection of external stimulus), GO:0021675 (nerve development), GO:0050790 (regulation of catalytic activity), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0098660 (inorganic ion transmembrane transport), GO:0044092 (negative regulation of molecular function), GO:0048513 (animal organ development), GO:0034762 (regulation of transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0009582 (detection of abiotic stimulus), GO:0034764 (positive regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0003013 (circulatory system process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0060004 (reflex), GO:0003012 (muscle system process), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0002027 (regulation of heart rate), GO:0098739 (import across plasma membrane), GO:0009888 (tissue development), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0043270 (positive regulation of monoatomic ion transport), GO:0006810 (transport), GO:0099623 (regulation of cardiac muscle cell membrane repolarization), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0032940 (secretion by cell), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0006935 (chemotaxis), GO:0030278 (regulation of ossification), GO:0090066 (regulation of anatomical structure size), GO:0009896 (positive regulation of catabolic process), GO:0098655 (monoatomic cation transmembrane transport), GO:0003018 (vascular process in circulatory system), GO:0043086 (negative regulation of catalytic activity), GO:0055006 (cardiac cell development), GO:0008015 (blood circulation), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0055001 (muscle cell development), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0006936 (muscle contraction), GO:0034694 (response to prostaglandin), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0050982 (detection of mechanical stimulus), GO:0099587 (inorganic ion import across plasma membrane), GO:0033273 (response to vitamin), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:1903522 (regulation of blood circulation), GO:0030855 (epithelial cell differentiation), GO:0035150 (regulation of tube size), GO:0043434 (response to peptide hormone), GO:0051591 (response to cAMP), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0007399 (nervous system development), GO:0086009 (membrane repolarization), GO:0003015 (heart process), GO:0051247 (positive regulation of protein metabolic process), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0060429 (epithelium development), GO:1901701 (cellular response to oxygen-containing compound), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0098659 (inorganic cation import across plasma membrane), GO:1904064 (positive regulation of cation transmembrane transport), GO:0031399 (regulation of protein modification process), GO:0060047 (heart contraction), GO:0098659 (inorganic cation import across plasma membrane), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0070588 (calcium ion transmembrane transport), GO:0097746 (blood vessel diameter maintenance), GO:0008016 (regulation of heart contraction), GO:0071805 (potassium ion transmembrane transport), GO:0035296 (regulation of tube diameter), GO:0001885 (endothelial cell development), GO:0003158 (endothelium development), GO:0014032 (neural crest cell development), GO:0050954 (sensory perception of mechanical stimulus), GO:0006939 (smooth muscle contraction), GO:1901016 (regulation of potassium ion transmembrane transporter activity), GO:0061337 (cardiac conduction), GO:1901379 (regulation of potassium ion transmembrane transport), GO:2001257 (regulation of cation channel activity), GO:0060048 (cardiac muscle contraction), GO:0030001 (metal ion transport), GO:1990573 (potassium ion import across plasma membrane), GO:0051924 (regulation of calcium ion transport), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)