Protein: Upstream stimulatory factor 1 (Major late transcription factor 1) (Q61069)
Organism: Mus musculus (Mouse)
Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Subcellular location: Nucleus.
Sequence: MKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNVKYVFRTENGGQVMYRVIQVSEGQLDGQTEGSGAISGYPATQSMTQAVIQGAFTSDDAVDTEGAAAETHYTYFPSTAVGDGSGGTTSGSTTAVVTTQGSEALLGQATPPSTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLRHHGLEVVIKNDSN
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [199-260]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [192-290]
- IPR051732: Upstream Stimulatory Factor (family) [2-308]
Interaction partners: - Upstream stimulatory factor 2
- Transcription factor Sp1
- Histone acetyltransferase p300
- General transcription factor II-I
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
- Mediator of RNA polymerase II transcription subunit 1
- Estrogen receptor
- Interferon regulatory factor 1
- Catenin beta-1
- Cellular tumor antigen p53
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0021700 (developmental maturation), GO:0002262 (myeloid cell homeostasis), GO:0048522 (positive regulation of cellular process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0046649 (lymphocyte activation), GO:0071695 (anatomical structure maturation), GO:0048872 (homeostasis of number of cells), GO:0035295 (tube development), GO:0034101 (erythrocyte homeostasis), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0048469 (cell maturation), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0035239 (tube morphogenesis), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0002521 (leukocyte differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0055123 (digestive system development), GO:0071310 (cellular response to organic substance), GO:0048732 (gland development), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0030855 (epithelial cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0030323 (respiratory tube development), GO:0030218 (erythrocyte differentiation), GO:0002064 (epithelial cell development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0002070 (epithelial cell maturation), GO:0048565 (digestive tract development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0042113 (B cell activation), GO:0060541 (respiratory system development), GO:0060575 (intestinal epithelial cell differentiation), GO:0002066 (columnar/cuboidal epithelial cell development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071345 (cellular response to cytokine stimulus), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0071345 (cellular response to cytokine stimulus), GO:0070741 (response to interleukin-6), GO:1903131 (mononuclear cell differentiation), GO:1990823 (response to leukemia inhibitory factor), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0002573 (myeloid leukocyte differentiation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1990830 (cellular response to leukemia inhibitory factor), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0002067 (glandular epithelial cell differentiation), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)