Protein: Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3) (O95394)
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.
Sequence: MDLGAITKYSALHAKPNGLILQYGTAGFRTKAEHLDHVMFRMGLLAVLRSKQTKSTIGVMVTASHNPEEDNGVKLVDPLGEMLAPSWEEHATCLANAEEQDMQRVLIDISEKEAVNLQQDAFVVIGRDTRPSSEKLSQSVIDGVTVLGGQFHDYGLLTTPQLHYMVYCRNTGGRYGKATIEGYYQKLSKAFVELTKQASCSGDEYRSLKVDCANGIGALKLREMEHYFSQGLSVQLFNDGSKGKLNHLCGADFVKSHQKPPQGMEIKSNERCCSFDGDADRIVYYYHDADGHFHLIDGDKIATLISSFLKELLVEIGESLNIGVVQTAYANGSSTRYLEEVMKVPVYCTKTGVKHLHHKAQEFDIGVYFEANGHGTALFSTAVEMKIKQSAEQLEDKKRKAAKMLENIIDLFNQAAGDAISDMLVIEAILALKGLTVQQWDALYTDLPNRQLKVQVADRRVISTTDAERQAVTPPGLQEAINDLVKKYKLSRAFVRPSGTEDVVRVYAEADSQESADHLAHEVSLAVFQLAGGIGERPQPGF
InterPro domains: - IPR049023: Phosphoacetylglucosamine mutase AMG1, domain II (domain) [178-283]
- IPR016657: Phosphoacetylglucosamine mutase (family) [1-533]
- IPR049022: Phosphoacetylglucosamine mutase AMG1, domain III (domain) [297-434]
- IPR016066: Alpha-D-phosphohexomutase, conserved site (conserved_site) [58-67]
- IPR016055: Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (homologous_superfamily) [75-376]
- IPR005843: Alpha-D-phosphohexomutase, C-terminal (domain) [476-524]
- IPR036900: Alpha-D-phosphohexomutase, C-terminal domain superfamily (homologous_superfamily) [436-539]
- IPR005844: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (domain) [51-167]
Interaction partners: - Glucosamine 6-phosphate N-acetyltransferase
- UDP-N-acetylhexosamine pyrophosphorylase
- UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
- N-acetyl-D-glucosamine kinase
- N-acetylglucosamine-6-phosphate deacetylase
- Phosphoglucomutase-1
- Phosphoglucomutase-like protein 5
- Glutamine--fructose-6-phosphate aminotransferase 1
- Phosphopentomutase
- Immunoglobulin lambda-like polypeptide 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0005515 (protein binding), GO:0016866 (intramolecular transferase activity), GO:0016868 (intramolecular transferase activity, phosphotransferases)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0045333 (cellular respiration), GO:0009117 (nucleotide metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009060 (aerobic respiration), GO:0009165 (nucleotide biosynthetic process), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009201 (ribonucleoside triphosphate biosynthetic process), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0046034 (ATP metabolic process), GO:0009145 (purine nucleoside triphosphate biosynthetic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0006119 (oxidative phosphorylation), GO:0006754 (ATP biosynthetic process), GO:0042776 (proton motive force-driven mitochondrial ATP synthesis), GO:0009206 (purine ribonucleoside triphosphate biosynthetic process), GO:0015986 (proton motive force-driven ATP synthesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)