Protein: ESX-5 secretion system protein EccC5 (ESX conserved component C5) (Type VII secretion system protein EccC5) (T7SS protein EccC5) (P9WNA5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.
Subcellular location: Cell inner membrane {ECO:0000250|UniProtKB:B2HST4}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MKRGFARPTPEKPPVIKPENIVLSTPLSIPPPEGKPWWLIVVGVVVVGLLGGMVAMVFASGSHVFGGIGSIFPLFMMVGIMMMMFRGMGGGQQQMSRPKLDAMRAQFMLMLDMLRETAQESADSMDANYRWFHPAPNTLAAAVGSPRMWERKPDGKDLNFGVVRVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSVVYNLPKMVSLLVEPWYALVGEREQVLGLMRAIICQLAFSHGPDHVQMIVVSSDLDQWDWVKWLPHFGDSRRHDAAGNARMVYTSVREFAAEQAELFAGRGSFTPRHASSSAQTPTPHTVIIADVDDPQWEYVISAEGVDGVTFFDLTGSSMWTDIPERKLQFDKTGVIEALPRDRDTWMVIDDKAWFFALTDQVSIAEAEEFAQKLAQWRLAEAYEEIGQRVAHIGARDILSYYGIDDPGNIDFDSLWASRTDTMGRSRLRAPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTLVRTVIESLMLSHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQALMERFLDALWGEIARRKAICDSAGVDDAKEYNSVRARMRARGQDMAPLPMLVVVIDEFYEWFRIMPTAVDVLDSIGRQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGVPNAVNLPAQAGLGYFRKSLEDIIRFQAEFLWRDYFQPGVSIDGEEAPALVHSIDYIRPQLFTNSFTPLEVSVGGPDIEPVVAQPNGEVLESDDIEGGEDEDEEGVRTPKVGTVIIDQLRKIKFEPYRLWQPPLTQPVAIDDLVNRFLGRPWHKEYGSACNLVFPIGIIDRPYKHDQPPWTVDTSGPGANVLILGAGGSGKTTALQTLICSAALTHTPQQVQFYCLAYSSTALTTVSRIPHVGEVAGPTDPYGVRRTVAELLALVRERKRSFLECGIASMEMFRRRKFGGEAGPVPDDGFGDVYLVIDNYRALAEENEVLIEQVNVIINQGPSFGVHVVVTADRESELRPPVRSGFGSRIELRLAAVEDAKLVRSRFAKDVPVKPGRGMVAVNYVRLDSDPQAGLHTLVARPALGSTPDNVFECDSVVAAVSRLTSAQAPPVRRLPARFGVEQVRELASRDTRQGVGAGGIAWAISELDLAPVYLNFAENSHLMVTGRRECGRTTTLATIMSEIGRLYAPGASSAPPPAPGRPSAQVWLVDPRRQLLTALGSDYVERFAYNLDGVVAMMGELAAALAGREPPPGLSAEELLSRSWWSGPEIFLIVDDIQQLPPGFDSPLHKAVPFVNRAADVGLHVIVTRTFGGWSSAGSDPMLRALHQANAPLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDTGVFVQVAATEVRR
InterPro domains: - IPR002543: FtsK domain (domain) [462-1354]
- IPR023837: EccCb-like, Actinobacteria (family) [794-1384]
- IPR023836: EccCa-like, Actinobacteria (family) [24-716]
- IPR003593: AAA+ ATPase domain (domain) [491-1372]
- IPR050206: FtsK/SpoIIIE/SftA cell division and DNA translocation (family) [37-786]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [230-1388]
Interaction partners: - ESX-5 secretion system protein EccD5
- ESX-5 secretion system ATPase EccB5
- ESX-5 secretion system protein EccE5
- Mycosin-5
- ESX-3 secretion system ATPase EccB3
- ESX-5 secretion-associated protein EspG5
- ESX-3 secretion system protein EccD3
- ESX-4 secretion system protein eccD4
- ESX-2 secretion system protein eccD2
- ESAT-6-like protein EsxB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0009607 (response to biotic stimulus), GO:0051234 (establishment of localization), GO:0140352 (export from cell), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0033036 (macromolecule localization), GO:0051701 (biological process involved in interaction with host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0071806 (protein transmembrane transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0075136 (response to host), GO:0032940 (secretion by cell), GO:0045184 (establishment of protein localization), GO:0035592 (establishment of protein localization to extracellular region), GO:0052200 (response to host defenses), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0015031 (protein transport), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0008104 (protein localization), GO:0071692 (protein localization to extracellular region), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)