Protein: Potassium voltage-gated channel subfamily A member 3 (RCK3) (RGK5) (Voltage-gated potassium channel subunit Kv1.3) (Voltage-gated potassium channel subunit Kv3) (P15384)
Organism: Rattus norvegicus (Rat)
Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19773357, ECO:0000269|PubMed:22613618, ECO:0000269|PubMed:27802162, ECO:0000269|PubMed:32370164}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MTVVPGDHLLEPEAAGGGGGDPPQGGCVSGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
InterPro domains: - IPR028325: Voltage-gated potassium channel (family) [54-454]
- IPR004050: Potassium channel, voltage dependent, Kv1.3 (family) [1-237]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [154-330]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [56-146]
- IPR003968: Potassium channel, voltage dependent, Kv (family) [96-429]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [54-153]
- IPR000210: BTB/POZ domain (domain) [54-154]
- IPR003972: Potassium channel, voltage dependent, Kv1 (family) [83-208]
- IPR005821: Ion transport domain (domain) [187-440]
Interaction partners: - Voltage-gated potassium channel subunit beta-2
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-3
- Potassium voltage-gated channel subfamily A member 1
- Intermediate conductance calcium-activated potassium channel protein 4
- Potassium voltage-gated channel subfamily A member 2
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Carbohydrate kinase-like, isoform CRA_b.
- Parvalbumin alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005102 (signaling receptor binding), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022832 (voltage-gated channel activity), GO:0005251 (delayed rectifier potassium channel activity), GO:0015271 (outward rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0001666 (response to hypoxia), GO:0090068 (positive regulation of cell cycle process), GO:0044085 (cellular component biogenesis), GO:0006979 (response to oxidative stress), GO:0098660 (inorganic ion transmembrane transport), GO:0070482 (response to oxygen levels), GO:0055093 (response to hyperoxia), GO:1901700 (response to oxygen-containing compound), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0010035 (response to inorganic substance), GO:0042127 (regulation of cell population proliferation), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0051481 (negative regulation of cytosolic calcium ion concentration), GO:0140115 (export across plasma membrane), GO:0016043 (cellular component organization), GO:0009612 (response to mechanical stimulus), GO:0010564 (regulation of cell cycle process), GO:0008284 (positive regulation of cell population proliferation), GO:0098655 (monoatomic cation transmembrane transport), GO:2000291 (regulation of myoblast proliferation), GO:0055075 (potassium ion homeostasis), GO:0007346 (regulation of mitotic cell cycle), GO:1901989 (positive regulation of cell cycle phase transition), GO:0036296 (response to increased oxygen levels), GO:0045931 (positive regulation of mitotic cell cycle), GO:0006811 (monoatomic ion transport), GO:0022607 (cellular component assembly), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:1901987 (regulation of cell cycle phase transition), GO:0036293 (response to decreased oxygen levels), GO:0097623 (potassium ion export across plasma membrane), GO:0043933 (protein-containing complex organization), GO:0042542 (response to hydrogen peroxide), GO:0000302 (response to reactive oxygen species), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0065003 (protein-containing complex assembly), GO:1902808 (positive regulation of cell cycle G1/S phase transition), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:0030001 (metal ion transport), GO:0051259 (protein complex oligomerization), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:1990351 (transporter complex), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0098797 (plasma membrane protein complex), GO:0042734 (presynaptic membrane), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:1902495 (transmembrane transporter complex), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0008076 (voltage-gated potassium channel complex), GO:0032279 (asymmetric synapse), GO:0034703 (cation channel complex), GO:0030424 (axon), GO:0044309 (neuron spine), GO:0034705 (potassium channel complex)