Protein: Ubiquitin-activating enzyme E1, putative (EC 6.3.2.19) (Q57XC5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MTSEEQRRQLYNRQEYVVGTETQAKYGCTDVLVVGACGLGAEIIKNLTLTGVRSIKVLDNGLATLQDLGTNFFLTPADMGKPRAEVVAARAQELNRFVSVTAVDVPLHEVIPAVHVVVFVNQRTTLLLAENAMARKHNVKFVACESRGVAGCVFVDAGPSFTVLDPDGEETVVCVVTNISRDGVVSLHEDKKHECEVGGRVFLTGLVSPESLNSTVDPFALHNGRATTECAQGDNSPTGASSSLRLFEVSEVVSPFHLRLKDFGAIVGDSPIETGYACYLHTTKRKVLVGFKDLQLSVMQPEFVTLFDSEKKMMAPMTLHALFRAVHSHGKLPTTPIEVRDVLKAAEAYFSSGNDQVHNGFDVETAESILSVMHGRLNPMDCFIGGLASQEVLKVCSGKFTPLRQWLYYDARELLVARGEMSETGCVSTAPGGSRYDGQIAVLGSSFQSFLSRQRVFIVGAGALGCELIKNVACMGFGAVSITDMDTIEMSNLSRQFLFRNSHIGQQKSKVAGEAARAINGDLKVSAYLEKVAQETENVFDEKFWESHSLVLNALDNVESRKYVDARCLFFRKPLFESGTLGPKCNVQCVIPYCTESYSSSYDPPEKSIPLCTLKNFPNVIEHTIQWARDNFDAVFFSTPSDVNGYLEDPTTFASNLERDPGTKSIVLKAVRDALVQWPKDAADCVRMARSLFHEYFNSSFRQLLHNLPLDKRNDNGDLFWSGAKKPPKPQEFSVDSELNVSFVYHCAKLLAQVYNLSAFTLSVKEVAELAMQVAVPGFVPREARFETNEAENKEGAAAQLVGDLTMQDLPPVSQFNSRRMNPLVFEKDDPNNSHMDYITACSNLRATAYSIPPADVHYTKRIAGRIIPAMVTTTALVTGLVGIEALKYLLLAHRENGAQGLAKANPITEKVQEEYLSLYRNAFVNVALPFMAFSDPIAAPAKTVPMPDGSSVRWGIWDRIDINEGRDITVKELVSILEKRHQLEIFIIALPCGKMVYSQFGNVKDRDKPVSVVVREKTKGEEKDELSCICFVATGSIGDNDVDIPLIYYRYKDF
InterPro domains: - IPR019572: Ubiquitin-activating enzyme, SCCH domain (domain) [618-861]
- IPR018965: Ubiquitin-activating enzyme E1, C-terminal (domain) [920-1048]
- IPR042302: Ubiquitin-activating enzyme E1, FCCH domain superfamily (homologous_superfamily) [170-283]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [962-974]
- IPR042449: Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 (homologous_superfamily) [1-118]
- IPR033127: Ubiquitin-activating enzyme E1, Cys active site (active_site) [610-618]
- IPR045886: ThiF/MoeB/HesA family (family) [434-1003]
- IPR000594: THIF-type NAD/FAD binding fold (domain) [11-913]
- IPR038252: Ubiquitin-activating enzyme E1, C-terminal domain superfamily (homologous_superfamily) [960-1053]
- IPR042063: Ubiquitin-activating enzyme E1, SCCH domain (homologous_superfamily) [603-868]
- IPR000011: Ubiquitin/SUMO-activating enzyme E1-like (family) [32-704]
- IPR035985: Ubiquitin-activating enzyme-like (homologous_superfamily) [5-890]
Interaction partners: - Ubiquitin-conjugating enzyme E2, putative
- Polyubiquitin, putative
- Ubiquitin-activating enzyme E1, putative
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-conjugating enzyme E2, putative
- E2 ubiquitin-conjugating enzyme
- Ubiquitin-conjugating enzyme E2, putative
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-like protein, putative
- Ubiquitin/ribosomal protein S27a, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0008641 (ubiquitin-like modifier activating enzyme activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016877 (ligase activity, forming carbon-sulfur bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)