Protein: Striatin-interacting protein 1 (Protein FAM40A) (Q8C079)
Organism: Mus musculus (Mouse)
Function: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Note=Enriched on the plasma membrane. {ECO:0000250}.
Sequence: MEPAAAGPGPLIVNNKQPQPPPPPPPATAQPPPGAPRAAGGLLPGGKAREFNRNQRKDSEGYSESPDLEFEYADTDKWAAELAELYSYTEGPEFLMNRKCFEEDFRIHVSDKKWTELDTNQHRTHAMRLLDGLEVTAREKRLKVARAILYVAQGTFGECSSEAEVQFWMRYNIFLLLEVGTFNALVELLNMEIDNSAACSSAVRKPAISLADSTDLRVLLNIMYLIVETVHQDCDGDKAEWRTMRQTFRAELGSPLYNNEPFAIMLFGMVTKFCSGHAPHFPMKKVLLLLWKTVLCTLGGFEELQSMKAEKRTLLGLPPLPEDSIKVIRNMRAASPPASASDLIEQQQKRGRREHKALIKQDNLDAFNERDPYKADDSREEEEENDDDSSLEGEAFPLERDEVMPPPLQHPQTDRLTCPKGLPWAPKVREKDIEMFLESSRSKFIGYTLGSDTNTVVGLPRPIHESIKTLKQHKYTSIAEVQAQMEEEYLRSPLSGGEEEVEQVPAETLYQGLLPSLPQYMIALLKILLAAAPTSKAKTDSINILADVLPEEMPTTVLQSMKLGVDVNRHKEVIVKAISAVLLLLLKHFKLNHIYQFEYMAQHLVFANCIPLILKFFNQNIMSYITAKNSISVLDYPHCVVNELPELTAESLEAGDNNQFCWRNLFSCINLLRILNKLTKWKHSRTMMLVVFKSAPILKRALKVKQAMMQLYVLKLLKVQTKYLGRQWRKSNMKTMSAIYQKVRHRLNDDWAYGNDLDARPWDFQAEECALRANIERFNARRYDRTHSNPDFLPVDNCLQSVLGQRVDLPEDFQMNYDLWLEREVFSKPISWEELLQ
InterPro domains: - IPR012486: Far11/STRP, N-terminal (domain) [65-363]
- IPR040185: Far11/STRP (family) [7-837]
- IPR021819: Far11/STRP, C-terminal (domain) [437-817]
Interaction partners: - Striatin-3
- Striatin
- Programmed cell death protein 10
- Striatin-4
- Serine/threonine-protein kinase 26
- CTTNBP2 N-terminal-like protein
- Serine/threonine-protein kinase 25
- MOB-like protein phocein
- Sarcolemmal membrane-associated protein
- Suppressor of IKBKE 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0000902 (cell morphogenesis), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0060674 (placenta blood vessel development), GO:0051147 (regulation of muscle cell differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)