Protein: Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Q68KI4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes. Can also exchange Li(+) and Cs(+) with a lower affinity. Involved in vacuolar ion compartmentalization necessary for cell volume regulation and cytoplasmic Na(+) detoxification. Required during leaves expansion, probably to stimulate epidermal cell expansion. Confers competence to grow in high salinity conditions.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:10455050}; Multi-pass membrane protein {ECO:0000269|PubMed:10455050}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:10455050}; Multi-pass membrane protein {ECO:0000305|PubMed:10455050}. Golgi apparatus membrane {ECO:0000305|PubMed:10455050}; Multi-pass membrane protein {ECO:0000305|PubMed:10455050}. Note=Tonoplast. Possibly also present in endoplasmic reticulum (ER) and Golgi apparatus.
Sequence: MLDSLVSKLPSLSTSDHASVVALNLFVALLCACIVLGHLLEENRWMNESITALLIGLGTGVTILLISKGKSSHLLVFSEDLFFIYLLPPIIFNAGFQVKKKQFFRNFVTIMLFGAVGTIISCTIISLGVTQFFKKLDIGTFDLGDYLAIGAIFAATDSVCTLQVLNQDETPLLYSLVFGEGVVNDATSVVVFNAIQSFDLTHLNHEAAFHLLGNFLYLFLLSTLLGAATGLISAYVIKKLYFGRHSTDREVALMMLMAYLSYMLAELFDLSGILTVFFCGIVMSHYTWHNVTESSRITTKHTFATLSFLAETFIFLYVGMDALDIDKWRSVSDTPGTSIAVSSILMGLVMVGRAAFVFPLSFLSNLAKKNQSEKINFNMQVVIWWSGLMRGAVSMALAYNKFTRAGHTDVRGNAIMITSTITVCLFSTVVFGMLTKPLISYLLPHQNATTSMLSDDNTPKSIHIPLLDQDSFIEPSGNHNVPRPDSIRGFLTRPTRTVHYYWRQFDDSFMRPVFGGRGFVPFVPGSPTERNPPDLSKA
InterPro domains: - IPR006153: Cation/H+ exchanger, transmembrane domain (domain) [28-439]
- IPR004709: Na+/H+ exchanger (family) [21-455]
- IPR018422: Cation/H+ exchanger, CPA1 family (family) [13-514]
Interaction partners: - Sodium transporter HKT1
- Calcineurin B-like protein 4
- CBL-interacting serine/threonine-protein kinase 24
- Probable calcium-binding protein CML18
- Pyrophosphate-energized vacuolar membrane proton pump 1
- Delta-1-pyrroline-5-carboxylate synthase A
- Calcineurin B-like protein 10
- Cation/H
- Vacuolar cation/proton exchanger 1
- K
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0022821 (solute:potassium antiporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0015385 (sodium:proton antiporter activity), GO:0015386 (potassium:proton antiporter activity), GO:0051139 (metal cation:proton antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0048878 (chemical homeostasis), GO:0055085 (transmembrane transport), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0050801 (monoatomic ion homeostasis), GO:0098739 (import across plasma membrane), GO:0010119 (regulation of stomatal movement), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0090333 (regulation of stomatal closure), GO:0098655 (monoatomic cation transmembrane transport), GO:0055075 (potassium ion homeostasis), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0099587 (inorganic ion import across plasma membrane), GO:0006811 (monoatomic ion transport), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0098659 (inorganic cation import across plasma membrane), GO:0030001 (metal ion transport), GO:1990573 (potassium ion import across plasma membrane), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)