Protein: Unconventional myosin-VIIb (Q6PIF6)
Organism: Homo sapiens (Human)
Function: Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli (Probable).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, microvillus {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}. Note=Enriched in the microvilli of the intestinal brush border. {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}.
Sequence: MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEAKPGKVLVEDDEGKEHWIRAEDFGVLSPMHPNSVQGVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGTPSEYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFMASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFEQLCINFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIISLLDEESRFPQGTDLTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQLQGKLRQMTLGITDVWLRTDKDWKAGKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRKEFLRQRRAAVTLQAWWRGYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGYLVRQQVQAKRRAVVVIQAHARGMAARRNFQQRKANAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEMVEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDLDTVPMAEEPEEDVDGLAEYTFPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLYARSSQQGSSVMRQIHDTLGREHGAQVPQHSRSAQVASQLNIGEEALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLSENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQGPATYGPFCAERLRRTYANGVRAEPPTWLELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKFWSLGSGRDHMMDAIARCEQMAQERGESQRQSPWRIYFRKEFFTPWHDSREDPVSTELIYRQVLRGVWSGEYSFEKEEELVELLARHCYVQLGASAESKAVQELLPSCIPHKLYRTKPPDRWASLVTAACAKAPYTQKQVTPLAVREQVVDAARLQWPLLFSRLFEVITLSGPRLPKTQLILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQRLLLSTMHEEYEFVSPSSVAIAELVALFLEGLKERSIFAMALQDRKATDDTTLLAFKKGDLLVLTKKQGLLASENWTLGQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPEKRKLAAQEGQFTEPRPEEPPKEKLHTLEEFSYEFFRAPEKDMVSMAVLPLARARGHLWAYSCEPLRQPLLKRVHANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQHPALQDEVYCQILKQLTHNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQLASWEGCSLFIKISDKVISQKEGDFFFDSLREVSDWVKKNKPQKEGAPVTLPYQVYFMRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTSYVQQLLSAMNKQRGSKAPALAST
InterPro domains: - IPR000048: IQ motif, EF-hand binding site (binding_site) [762-876]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [1291-2007]
- IPR001609: Myosin head, motor domain-like (domain) [59-761]
- IPR019749: Band 4.1 domain (domain) [1193-2012]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1407-2104]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [1286-2007]
- IPR002404: IRS-type PTB domain (domain) [2012-2098]
- IPR041794: Myosin VII, FERM domain C-lobe, repeat 2 (domain) [2008-2103]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [1505-1567]
- IPR000857: MyTH4 domain (domain) [989-1793]
- IPR038185: MyTH4 domain superfamily (homologous_superfamily) [965-1793]
- IPR036106: Class VII myosin, motor domain (domain) [79-748]
- IPR051567: Unconventional Myosin ATPase (family) [5-1277]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [44-882]
- IPR041793: Myosin VII, FERM domain C-lobe, repeat 1 (domain) [1406-1502]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1192-1898]
- IPR000299: FERM domain (domain) [1197-2102]
- IPR001452: SH3 domain (domain) [1501-1567]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [68-686]
- IPR019748: FERM central domain (domain) [1910-2012]
Interaction partners: - Harmonin
- Ankyrin repeat and SAM domain-containing protein 4B
- Cadherin-related family member 2
- Cadherin-related family member 5
- pre-mRNA splicing regulator USH1G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0000146 (microfilament motor activity), GO:0051015 (actin filament binding), GO:0030507 (spectrin binding), GO:0005516 (calmodulin binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0003008 (system process), GO:0030048 (actin filament-based movement), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0050905 (neuromuscular process), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0006996 (organelle organization), GO:0007600 (sensory perception), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0050953 (sensory perception of light stimulus), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0007033 (vacuole organization), GO:0050885 (neuromuscular process controlling balance), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0050954 (sensory perception of mechanical stimulus), GO:0150063 (visual system development), GO:0007605 (sensory perception of sound), GO:0007601 (visual perception), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development), GO:0080171 (lytic vacuole organization), GO:0007040 (lysosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0001750 (photoreceptor outer segment), GO:0001917 (photoreceptor inner segment), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0005929 (cilium), GO:0098588 (bounding membrane of organelle), GO:0005764 (lysosome), GO:0098852 (lytic vacuole membrane), GO:0097730 (non-motile cilium), GO:0097733 (photoreceptor cell cilium), GO:0097731 (9+0 non-motile cilium), GO:0005765 (lysosomal membrane)