Protein: NF-kappa-B essential modulator (Inhibitor of nuclear factor kappa B kinase subunit gamma) (DmIKKgamma) (NEMO homolog) (Q9GYV5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for NF-kappa-B (Rel) activation. Required for antibacterial immune response.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Sequence: MSDEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAEETVASTSTQPPTVNCIPVSITASQQQHKSLDSGSSQQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLDKVNQTMLNYHNLTQQWRQEAADREHQYKEHVKECQAQIAILRVENQELKRDLETKIEQIEGVHTIRLKEQDELRKSVSEKQSLIDNMRVEIDKLKQLNHSFEFVPEYATESKSQELIKKMQLDINELKARDIQKQEVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQRRNQELIEALAESHKASKACSTASPLSSSRSNLREEQRPILDPTGASSRTSDTTLRCPICSKSFNALSVLQSHVNDCLDKN
InterPro domains: - IPR032419: NF-kappa-B essential modulator NEMO, CC2-LZ domain (domain) [242-312]
- IPR034735: NEMO, Zinc finger (domain) [355-385]
- IPR051301: Optineurin/NF-kappa-B Essential Modulator (family) [241-385]
Interaction partners: - Inhibitor of nuclear factor kappa-B kinase subunit beta
- Mitogen-activated protein kinase kinase kinase 7
- Nuclear factor NF-kappa-B p110 subunit
- LD40663p
- Fas-associated death domain protein
- Putative mitogen-activated protein kinase kinase kinase 7-like
- FI16976p1
- Protein immune deficiency
- ubiquitinyl hydrolase 1
- GEO06356p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0045786 (negative regulation of cell cycle), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0045787 (positive regulation of cell cycle), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0000075 (cell cycle checkpoint signaling), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:1901988 (negative regulation of cell cycle phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:0032006 (regulation of TOR signaling), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0032007 (negative regulation of TOR signaling), GO:0070647 (protein modification by small protein conjugation or removal), GO:0035330 (regulation of hippo signaling), GO:0000077 (DNA damage checkpoint signaling), GO:1904262 (negative regulation of TORC1 signaling), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)