Protein: Mitogen-activated protein kinase 9 (MAP kinase 9) (MAPK 9) (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (P79996)
Organism: Gallus gallus (Chicken)
Function: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).
Sequence: MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESDRDKLKTSQARDLLSKMLVVDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSAQMQQ
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [13-356]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [147-159]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [24-343]
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [61-163]
- IPR000719: Protein kinase domain (domain) [26-321]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [76-335]
Interaction partners: - mitogen-activated protein kinase kinase
- Transcription factor Jun
- Stress-activated protein kinase JNK
- Mitogen-activated protein kinase.
- Mitogen-activated protein kinase kinase 7.
- Transcription factor JunD
- Nuclear factor of activated T cells 3
- Protein c-Fos
- Mitogen-activated protein kinase 8 interacting protein 2.
- Dual specificity protein phosphatase 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0140297 (DNA-binding transcription factor binding), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0033554 (cellular response to stress), GO:0000165 (MAPK cascade), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0051403 (stress-activated MAPK cascade), GO:0007254 (JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)