Protein: Calcium-transporting ATPase (A0A8M2BEU8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the hydrolysis of ATP coupled with the transport of calcium
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MENAHTKSVEEVYSNFSVNESTGLTLDQVKRNRDKWGPNELPAEEGKSIWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEVAVGDKVPADIRISAIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAIGVVVATGVNTEIGKIRDEMASTEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFIIDKAEGENCSLTEFTISGSTYAPEGDVCLDNRIVKCSQYDGLVELATICALCNDSSLDFNESKGVYEKVGEATETALTCLVEKMNVFDTDVRNLSKIERANACNAVIKQLMKKEFTLEFSRDRKSMSVYCSPNKAKSSSSKMFVKGAPEGVIDRCAYVRVGGSKVPLTQGIKDKIMSVIREYGTGRDTLRCLALATRDNPLKKEEMVLSDTARFADYESDLTFVGCVGMLDPPRTEVAASIKLCRHAGIRVIMITGDNKGTAVAICRRIGIFSDEDDVHRMAFTGREFDDLSPHAQREAVTVARCFARVEPSHKSKIVEFLQGFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRSAKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIVADDGPMITLYQLSHFLQCSPDNPDFQDLECHVFESPYPMTMALSVLVTIEMCNALNSLSENQSLVRMPPWENIWLLGAICLSMSLHFLILYVEPLPVIFQITPLNVTQWMMVLKISLPVILLDELLKFVARTYLEPGKDLKEEKEDRRGWSFSACTDGVSWPFIALTLPLVVWLYSTNITQLFRHS
InterPro domains: - IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [3-77]
- IPR023214: HAD superfamily (homologous_superfamily) [346-743]
- IPR036412: HAD-like superfamily (homologous_superfamily) [585-747]
- IPR005782: P-type ATPase, subfamily IIA, SERCA-type (family) [53-854]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [330-751]
- IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [131-237]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [356-600]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [351-357]
- IPR001757: P-type ATPase (family) [93-780]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [782-985]
- IPR059000: P-type ATPase, A domain (domain) [123-239]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [1-990]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0140358 (P-type transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0009799 (specification of symmetry), GO:0048513 (animal organ development), GO:0003002 (regionalization), GO:0048731 (system development), GO:0009855 (determination of bilateral symmetry), GO:0060972 (left/right pattern formation), GO:0072359 (circulatory system development), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0098588 (bounding membrane of organelle), GO:0033017 (sarcoplasmic reticulum membrane)