Protein: Serine/threonine-protein kinase nekl-2 (EC 2.7.11.1) (Never in mitosis A kinase-like 2) (NimA-kinase-like 2) (O01775)
Organism: Caenorhabditis elegans
Function: Probable serine/threonine-protein kinase required for the completion of molting. May play a role in endocytosis in the hypodermis syncytium.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25523392}. Note=In hyp7 syncytium, localizes in puncta and small tubules near the plasma membrane apical region. Does not co-localize with nekl-3. {ECO:0000269|PubMed:25523392}.
Sequence: MDNYEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTKSAASTVIGTPNYLSPEICESRPYNQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSDPLVLPYLISIHCDLGRIEPPPTDKRKPSASLSSRLRTYPTQSTLRPYSLSSNAPTTHLTQLTPMPSHIDSGFFSSGRTSNQRTQSRSQVHSKY
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1-350]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [133-145]
- IPR051131: NEK Ser/Thr protein kinase family, NIMA subfamily (family) [1-270]
- IPR017441: Protein kinase, ATP binding site (binding_site) [10-35]
- IPR000719: Protein kinase domain (domain) [4-267]
Interaction partners: - SAM domain-containing protein
- ANK_REP_REGION domain-containing protein
- ANK_REP_REGION domain-containing protein
- JmjC domain-containing protein
- Probable [pyruvate dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051726 (regulation of cell cycle), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0045786 (negative regulation of cell cycle), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0009416 (response to light stimulus), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:1901988 (negative regulation of cell cycle phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0044819 (mitotic G1/S transition checkpoint signaling), GO:0009411 (response to UV), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902807 (negative regulation of cell cycle G1/S phase transition), GO:0000077 (DNA damage checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:2000134 (negative regulation of G1/S transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)