wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: FpvR (Q9I192)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
Sequence: MKTPSPADSDTLVQDAAHWCMRLHAEDFSEEERGEFQRWLAADPRHAAEYAEMEEIWALSELLPRTPAPELRNHAATRPLGRRRRGWKSQARAAALALLMLPTAGYLGWLQGWIPSNYQRYEAEGNVRHAVLPDGSEVELDLNTQLSFANFKDIRRVSLDRGEAYFHVTHDSAHPFVVKAGNGSITVTGTRFNVWKYQDNVVVTVTEGSVKVRSEGSGNDSSLTPGMQASYYPGLLQPLVEAVDTRQTLAWREGRLVLDDLPLSKALPLINRYLDAPLVLGDRSAAKLRIGGIYSTRDIRSLVDALPKVLPVDLEHREDGSIRISSRYAQL
InterPro domains: - IPR006860: FecR protein (domain) [124-211]
- IPR032623: FecR, N-terminal (domain) [14-55]
- IPR012373: Fe(2+)-dicitrate sensor, transmembrane component (family) [4-327]
Interaction partners: - FpvI
- Ferripyoverdine receptor
- Sigma factor PvdS
- ECF sigma factor FoxI
- Lysyl endopeptidase
- ECF sigma factor, FemI
- ECF sigma factor, VreI
- Probable sigma-70 factor, ECF subfamily
- Pyoverdine export membrane fusion protein PvdR
- Pyoverdine export outer membrane protein OpmQ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0003714 (transcription corepressor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032879 (regulation of localization), GO:0051049 (regulation of transport), GO:0043269 (regulation of monoatomic ion transport), GO:0010959 (regulation of metal ion transport), GO:0034756 (regulation of iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) (P27633)
Organism: Xenopus laevis (African clawed frog)
Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis. Binds to the promoters of select genes.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P20226}.
Sequence: MDQNNSIPPFQGLASPQGSLTPGINIFSPLITYGTGLTPQPVQTTNSLSILEEQQRQQQQTQQSTLQQGNQGSGQTPQLFHPQTLTTAPLPGNTPLYPSPITPMTPISPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT
InterPro domains: - IPR012295: TBP domain superfamily (homologous_superfamily) [124-293]
- IPR030491: TATA-box binding protein, conserved site (conserved_site) [241-290]
- IPR033710: TATA-box binding protein, eukaryotic (family) [120-293]
- IPR000814: TATA-box binding protein (family) [57-296]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Klrc3 protein (A1L3Q6)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Sequence: MSHLLGTEQASEPRKATKKTQAQLHFSNAAGDRLLEFSLQHASQKHLKASRHGYCKNFASPPEKLIAGILGTIWFTLLIALVISTRIVSPYAELKKQIHPFLVRTQKGSHVLLSKDINHSLSSAQTYAHCPKEWILYSHNCYYIGMERKSWNDSLVSCISKNCSLLHIDSEEEQDFLQSLSLVSWTGILRKGRGQPWVWKKDSTFKPKIAEILHNECNCAMMSASGLTADSCTTLHPYLCKCKFPI
InterPro domains: - IPR050919: NKG2/CD94 Natural Killer Receptors (family) [30-243]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [116-244]
- IPR016187: C-type lectin fold (homologous_superfamily) [119-244]
- IPR001304: C-type lectin-like (domain) [130-241]
- IPR033992: Natural killer cell receptor-like, C-type lectin-like domain (domain) [130-242]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:0051049 (regulation of transport), GO:0051282 (regulation of sequestering of calcium ion), GO:0043270 (positive regulation of monoatomic ion transport), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0043269 (regulation of monoatomic ion transport), GO:0051928 (positive regulation of calcium ion transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1904064 (positive regulation of cation transmembrane transport), GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol), GO:0010959 (regulation of metal ion transport), GO:1904427 (positive regulation of calcium ion transmembrane transport), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0051924 (regulation of calcium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)
Protein: Trace amine-associated receptor 1 (Q5QNP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MDDHINISQTESWEKPLLCYEFSNRSCQKFVYPLDTRILLYMLFSISSIITIIGNLLVIITVVHFRQLHTPTNYLILSLAVADLLVGGVVMPPSMLRSIETCWYLGDLFCKIHSSLDVTLCTASILNLCIISLDRYYAICHPFQYHSKMTSLATLIMIIICWTVSAVLGFGMIFMELNILGVEDFYYENIRCDGGCFVFQSKTGGTVFSLICFYIPAFVMLGVYLKILHEAQRQVQAIQSVNSELKKEGKATKTLAIIMGVFLTFWIPFFLCNLIDPLIGYSVPSLVFDLFLWVGYYNSTCNPIVYAFFYSWFRHAFRVILSKRVFQTNSSRTILM
InterPro domains: - IPR009132: Trace amine associated receptor family (family) [61-289]
- IPR050569: Trace Amine-Associated Receptor (family) [24-321]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [54-306]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [39-321]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050793 (regulation of developmental process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0050795 (regulation of behavior), GO:1901343 (negative regulation of vasculature development), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0090398 (cellular senescence), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0007600 (sensory perception), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Putative indole-3-acetic acid-amido synthetase GH3.9 (EC 6.3.2.-) (Auxin-responsive GH3-like protein 9) (AtGH3-9) (O82243)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the synthesis of indole-3-acetic acid (IAA)-amino acid conjugates, providing a mechanism for the plant to cope with the presence of excess auxin.
Sequence: MDVMKLDHDSVLKELERITSKAAEVQDNILRGILERNKDTEYLSKYMNGSKDVLEFKRAVPIIIYKDIYPYIQRIANGEDSSLITGHSITEILCSSGTSAGEPKLMPTIPEDLDRRTFLYNLIIPIVNKYITGLDKGKAMYLNFVKAETSTPCGLPIRAVLTSYYKSKHFQCRPYDPFNDLTSPIQTILCEDSNQSMYCQLLAGLIHRHKVMRLGAVFASAFLRAISYLEKKWSQLCEDIRTGSLNPMITDPGCQMAMSCLLMSPNPELASEIEEICGRSSWKGILCQLWPKAKFIEAVVTGSMAQYIPALEFFSQGKIPLVCPMYASSETYFGVNVEPLSKPSDVVFTLLPNMCYFEFIPLGKNGTLSFDLDDDEQVPCDKVVDLVNVKLGRYYELVVTTFAGLYRYRIGDVLQVAGFYNGAPQFRFICRRNVVLSIDLDKTNEEDLHRSITLAKKKLGSNAFLAEYTSYADTSSVPGHYVLFWEIQGHLEPKLMEECCVAVEEELDYIYRQCRTKERSIGALEIRVVKPGTFEKLMDLIISQGGSFNQYKTPRCVKSNSATFKLLNGHVMASFFSPRDPTWVP
InterPro domains: - IPR055378: GH3, C-terminal domain (domain) [446-560]
- IPR055377: GH3, middle domain (domain) [348-431]
- IPR004993: GH3 family (family) [6-578]
Interaction partners: - Auxin transporter protein 1
- Alpha/beta-Hydrolases superfamily protein
- Two-component response regulator ARR16
- Serine/threonine-protein kinase SRK2J
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0010252 (auxin homeostasis), GO:0009733 (response to auxin)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Heterogeneous nuclear ribonucleoprotein U (A0A1W2PP34)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MFTLDVKSNTVFDIITDNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGVSNFLCALCTLIVF
InterPro domains: - IPR035778: Heterogeneous nuclear ribonucleoprotein U, SPRY domain (domain) [16-187]
- IPR003877: SPRY domain (domain) [55-187]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [16-190]
- IPR001870: B30.2/SPRY domain (domain) [1-188]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [218-394]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [12-221]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:0009615 (response to virus), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Glycosyltransferase (Homeodomain-like superfamily protein) (Q7X887)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGKSSGRNGNGSFNGNKFHGVRPYVRSPVPRLRWTPDLHRCFVHAVEILGGQHRATPKLVLKMMDVKGLTISHVKSHLQMYRGGSKLTLEKPEESSSSSIRRRQDSEEDYYLHDNLSLHTRNDCLLGFHSFPLSSHSSFRGGGGGRTKEQQTSESGGYDDDADFLHIKKMNDTTTFLSHHFPKGTEEWREQEHEEEEEDLSLSLSLNHHHWRSNGSSVVSETSEAAVSTCSAPFVSKDCFGSSKIDLNLSISLLGS
InterPro domains: - IPR001005: SANT/Myb domain (domain) [31-82]
- IPR046955: Myb family transcription factor PHR1-like (family) [19-226]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [30-82]
- IPR017930: Myb domain (domain) [26-86]
- IPR006447: Myb domain, plants (domain) [30-82]
Interaction partners: - Uncharacterized protein At4g19900
- Glycosyltransferase-pyrophosphoryl-undecaprenol N-acetylglucosamine transferase)
- Glycosyltransferase
- At3g57630
- At1g19710
- dolichyl-phosphate beta-glucosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase 1
- Pentatricopeptide repeat-containing protein At5g03800
- Beta-arabinofuranosyltransferase RAY1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q38EW0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein {ECO:0000256|RuleBase:RU365079}.
Sequence: MVRTTRFSRNSSKPLFQQLQLITSYGLFQEYPPIWSLPLPPQQPRDTGKPTLVLDIDETLIHTVGMRNEGSDSVSFSFFLRPHAKEFLAEVRELYEVVFWTAGTASYCSAVMDALEVQVLQLPRSFYNIDELRVEARGGISTKNVNFYALSRTQTLQGHNYMKYLPMLGRPLNRVIVIDSDVRSFPLHPRNGVKIEPFLPNERVLSEYARVVTDEVKYGQVGQRQYEGEMAKVIERGEEEVARLQADHALMDLIPMLRSAASSTDLTHELDHWRTDEYTKCDDFRETMNSLSVTRQKILGNVLKERRNVPIPPLKQHVMNHGFMEEANAAMKLEQMRHTPSRL
InterPro domains: - IPR004274: FCP1 homology domain (domain) [45-218]
- IPR023214: HAD superfamily (homologous_superfamily) [35-276]
- IPR050365: Mitochondrial import inner membrane translocase subunit TIM50 (family) [44-271]
- IPR036412: HAD-like superfamily (homologous_superfamily) [37-202]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0020015 (glycosome)
Protein: E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Tripartite motif-containing protein 47) (Q8C0E3)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q96LD4}. Nucleus {ECO:0000250|UniProtKB:Q96LD4}.
Sequence: MDGSGPFSCPICLEPLREPVTLPCGHNFCLACLGALWPHRSAGGTGGSGGPARCPLCQEPFPDGLQLRKNHTLSELLQLRQGSVPGPMSAPASGSTRGATPEPSAPSAPPPAPEPSAPCAPEQWPAGEEPVRCDACPEGAALPAALSCLSCLASFCSAHLAPHERSPALRGHRLVPPLRRLEESLCPRHLRPLERYCRVERVCLCEACATQDHRGHELVPLEQERALQEVEQSKVLSAAEDRMDELGAGIAQSRRTVALIKSAAVAERERVSQMFAEATATLQSFQNEVMGFIEEGEATMLGRSQGDLRRQEEQRSRLSKARHNLGQVPEADSVSFLQELLALRLALEEGCGPGPGPPRELSFTKSSQVVKAVRDTLISACASQWEQLRGLGSNEDGLQKLGSEDVESQDPDSTSLLESEAPRDYFLKFAYIVDLDSDTADKFLQLFGTKGVKRVLCPINYPESPTRFTHCEQVLGEGALDRGTYYWEVEIIEGWVSVGVMAEGFSPQEPYDRGRLGRNAHSCCLQWNGRGFSVWFCGLEAPLPHAFSPTVGVCLEYADHALAFYAVRDGKLSLLRRLKASRPRRSGALASPTDPFQSRLDSHFSGLFNHRLKPAFFLESVDAHLQIGPLKKSCITVLKRR
InterPro domains: - IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [24-33]
- IPR000315: B-box-type zinc finger (domain) [128-221]
- IPR042780: TRIM47, PRY/SPRY domain (domain) [424-629]
- IPR058030: TRIM8/14/16/25/29/45/65, coiled-coil region (domain) [250-381]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [423-575]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [9-38]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [4-82]
- IPR001870: B30.2/SPRY domain (domain) [413-634]
- IPR051051: E3 ubiquitin-protein ligase TRIM/RNF (family) [7-616]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [415-593]
- IPR001841: Zinc finger, RING-type (domain) [9-58]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)