Protein: Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) (Q9TT37)
Organism: Oryctolagus cuniculus (Rabbit)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity).
Subcellular location: Cell membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
Sequence: MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQVPQIQKTEIAFRPSDPKSYEEYVVNIVRFLEKYKDSAQKDDMVFEDCGDVPSEPKERGEFNNERGQRKVCRFKLNWLGNCSGIDDETYGYKDGKPCIIIKLNRVLGFKPKPPKNDSLEFSPGTKYNPNVLPVQCTGKRDEDKEKVGSMEYFGMGDYAGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
InterPro domains: - IPR038702: Sodium/potassium-transporting ATPase subunit beta superfamily (homologous_superfamily) [62-303]
- IPR000402: Sodium/potassium-transporting ATPase subunit beta (family) [2-303]
Interaction partners: - FXYD domain-containing ion transport regulator
- Sodium/potassium-transporting ATPase subunit alpha-1
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit alpha
- Sodium/potassium-transporting ATPase subunit beta-2
- Sodium/potassium-transporting ATPase subunit beta-3
- Phospholemman
- Potassium-transporting ATPase alpha chain 2
- cAMP-dependent protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140677 (molecular function activator activity), GO:0060590 (ATPase regulator activity), GO:0005515 (protein binding), GO:0001671 (ATPase activator activity), GO:0019899 (enzyme binding), GO:0051117 (ATPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:1902495 (transmembrane transporter complex), GO:0098857 (membrane microdomain), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0045121 (membrane raft), GO:0098533 (ATPase dependent transmembrane transport complex), GO:0044853 (plasma membrane raft), GO:0016323 (basolateral plasma membrane), GO:0005890 (sodium:potassium-exchanging ATPase complex), GO:0005901 (caveola), GO:0090533 (cation-transporting ATPase complex)