Protein: Chromatin structure-remodeling complex subunit snf21 (EC 3.6.4.-) (ATP-dependent helicase snf21) (RSC complex subunit snf21) (Q9UTN6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Helicase. Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:16823372}. Note=Localizes to centromeric and flanking chromatin. {ECO:0000250}.
Sequence: MRAEKQYTRNEVEETIVRWKKLKESGATEHDNTEYAQLCDVLRSAQSEIEARRDLKGHIKRCFSSVDKNTEKLILKQQVLAYKKLSQNLPAPDDCILSVLLRLSKDEQLLQSIVKQPLQNSKVDGKVRRDFGSCQITPSAKQQRKYLQYQISEDDAIKNRMFRRMSDLESYPAVMRDVAELKDDNERLNLDTIKRNALVELKKLRLIKQQESLRHQVMHCQPHLRTIVNAVERMSCRRPKLVPQATRLTEVLERQQRSDRERRLKQKQCDYLQTVCAHGREINVRTKNAQARAQKANRAVLAYHSHIEKEEQRRAERNAKQRLQALKENDEEAYLKLIDQAKDTRITHLLRQTDHYLDSLAAAVKVQQSQFGESAYDEDMDRRMNPEDDRKIDYYNVAHNIREVVTEQPSILVGGKLKEYQLRGLQWMISLYNNHLNGILADEMGLGKTIQTISLITHLIEKKRQNGPFLVIVPLSTLTNWTMEFERWAPSIVKIVYKGPPQVRKALHPQVRHSNFQVLLTTYEYIIKDRPLLSRIKWIYMIIDEGHRMKNTQSKLTNTLTTYYSSRYRLILTGTPLQNNLPELWALLNFVLPRIFNSIKSFDEWFNTPFANTGGQDKMELTEEESLLVIRRLHKVLRPFLLRRLKKDVEAELPDKVEKVIRCQMSGLQQKLYYQMKKHGMLYVEDAKRGKTGIKGLQNTVMQLKKICNHPFVFEDVERSIDPTGFNYDMLWRVSGKFELLDRILPKLFRSGHRILMFFQMTQIMNIMEDYLHYRQWRYLRLDGSTKADDRSKLLGVFNDPTAEVNLFLLSTRAGGLGLNLQTADTVIIFDSDWNPHQDLQAQDRAHRIGQTKEVRIYRLITEKSVEENILARAQYKLDIDGKVIQAGKFDNKSTPEEREAFLRSLLENENGEEENDEKGELDDDELNEILARGDDELRLFKQMTEDLERESPYGKNKEKERLIQVSELPEFYQREEPEKTTDLLQEEPLGRGARRRTPVVYDEAVRDAQWMAEMDMESEARPTRGRPKRNIASVDETPALTLNGKPKKKRGPAPDTLTSEHRSLLRRVCLEIYKAVNELEDDNGRPLNKLFLELPSKKLYPDYYMIIKSPIALDAIRKHINGTFYKTLEAMKSDLMTMFNNARTYNEEGSFVYEDANKMQTAMETKIEELEEDGTLATLRGMEAEATSQLEDRIENEA
InterPro domains: - IPR000330: SNF2, N-terminal (domain) [420-712]
- IPR049730: SNF2/RAD5-like, C-terminal helicase domain (domain) [734-861]
- IPR038718: SNF2-like, N-terminal domain superfamily (homologous_superfamily) [408-653]
- IPR018359: Bromodomain, conserved site (conserved_site) [1089-1146]
- IPR014012: Helicase/SANT-associated domain (domain) [256-328]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [387-931]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [413-602]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [1049-1199]
- IPR001650: Helicase, C-terminal domain-like (domain) [737-903]
- IPR029295: Snf2, ATP coupling domain (domain) [946-1012]
- IPR001487: Bromodomain (domain) [1063-1173]
Interaction partners: - SWI/SNF and RSC complexes subunit arp9
- SWI/SNF and RSC complexes subunit arp42
- SWI/SNF and RSC complexes subunit ssr3
- SWI/SNF and RSC complexes subunit ssr1
- Chromatin structure-remodeling complex subunit rsc7
- SWI/SNF and RSC complexes subunit ssr2
- Chromatin structure-remodeling complex subunit sfh1
- Chromatin structure-remodeling complex subunit rsc9
- Chromatin structure-remodeling complex subunit rsc4
- Chromatin structure-remodeling complex subunit rsc1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0004386 (helicase activity), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0005515 (protein binding), GO:0140658 (ATP-dependent chromatin remodeler activity), GO:0140097 (catalytic activity, acting on DNA), GO:0003678 (DNA helicase activity), GO:0043138 (3'-5' DNA helicase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0044237 (cellular metabolic process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007131 (reciprocal meiotic recombination), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0007127 (meiosis I), GO:0048285 (organelle fission), GO:0006310 (DNA recombination), GO:0000280 (nuclear division), GO:0035825 (homologous recombination), GO:0140527 (reciprocal homologous recombination), GO:0035822 (gene conversion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0070603 (SWI/SNF superfamily-type complex), GO:0043229 (intracellular organelle), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0016586 (RSC-type complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)