Protein: Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (Q9Z101)
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q9NPB6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NPB6}. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism. {ECO:0000250|UniProtKB:Q9NPB6}.
Sequence: MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEGDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSVGPGPTDPDSDDDSSDLVIENRHPPCSNGLSQGPLCWDLQPGCLLPGAGSSLPSLDSREQANSGWGNGMRGDVSGFSL
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [128-253]
- IPR051741: Partitioning defective 6 homolog protein (family) [5-253]
- IPR053793: PB1-like domain (domain) [15-95]
- IPR000270: PB1 domain (domain) [15-95]
- IPR034868: Partitioning defective protein 6, PB1 domain (domain) [16-95]
- IPR001478: PDZ domain (domain) [157-250]
Interaction partners: - Protein kinase C zeta type
- Cell division control protein 42 homolog
- Partitioning defective 3 homolog
- Protein kinase C iota type
- Protein PALS1
- Segment polarity protein dishevelled homolog DVL-2
- Ras-related C3 botulinum toxin substrate 2
- Ras-related C3 botulinum toxin substrate 1
- Ras-related C3 botulinum toxin substrate 3
- Glycogen synthase kinase-3 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0060341 (regulation of cellular localization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0030427 (site of polarized growth), GO:0150034 (distal axon), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0030426 (growth cone), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0044295 (axonal growth cone), GO:0030424 (axon)