wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: LEM3 (Ligand-effect modulator 3) family / CDC50 family (Q382L6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MARGGVVRLPSFIDVPPSTETDREGGRSCFGKYGRTAYGGNPIVQQTLPSTFFYIAPQYVIPLFFAVSFVFIPISITLFITCNGHYEVRGNYQHIHKYQYIPSDPKVNINEGIRSFYVGNEVHRQGTRTRVSFKLEKPMKKPVYLYYTLGNFHQNFRAFHEGRSLDMLRGHRSIIGSYPECQPYERPGTINKAEKTEVKVVVDGENVTLKYEEFLYNPCGIAPWSMFNDTFVLYRSRDVSSAQNDSVKLDEGAELICNTSDFGPTGEPLYQSKTPNKCKKKGISWPADEKIRFRPLERDKKLWSLRYPHKNDNVYLTNGWYADEPGHRLTDPEDYDMQVWIRAAFLSNFSKLFRIIDEDLREGNYFLDIEEFFDVTTFHGTKGYLLRTSSMFGRSGTLFAATFLIVGSVAFVVGVAFAIQYCMAKKGLGNSLPQPKASWYTFNRTGLDIQNYFQLRTKRYEICPQSSDDE
InterPro domains: - IPR005045: CDC50/LEM3 family (family) [39-436]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0007267 (cell-cell signaling), GO:0007154 (cell communication), GO:0051606 (detection of stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0006810 (transport), GO:0009372 (quorum sensing), GO:0060245 (detection of cell density)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Dynein axonemal assembly factor 1 homolog (Defective transmitter-recycling protein) (Leucine-rich repeat-containing protein 50 homolog) (Q9U3W5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell projection, cilium {ECO:0000256|ARBA:ARBA00004138}.
Sequence: MGDADRAMNEPEAAKTVSGIQVIPAEDVASIEDIITIDPDCYELDLNHRRIEKLENFEPLTRIERLFLRWNLIKKIENLSSLKTLIELELYDNQITKIENLDDLPHLEVLDISFNRLTKIENLDKLVKLEKVYFVSNRITQIENLDMLTNLTMLELGDNKLKKIENIEMLVNLRQLFLGKNKIAKIENLDTLVNLEILSLQANRIVKIETLEKLANLRELYVSENGVETIENLSENTKLETLDLAKNRLKGIANLEKLELLEELWLNHNGVDDWKDIELLKVNKALQTIYLEYNPLAKDVRYRSKLRDILPQLQKIDATLCKVPGT
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [22-323]
- IPR050576: Ciliary and flagellar integrity-associated protein (family) [180-317]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [60-236]
- IPR001611: Leucine-rich repeat (repeat) [62-281]
- IPR025875: Leucine rich repeat 4 (repeat) [84-276]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009791 (post-embryonic development), GO:0007163 (establishment or maintenance of cell polarity), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0008285 (negative regulation of cell population proliferation), GO:0048513 (animal organ development), GO:0002164 (larval development), GO:0009886 (post-embryonic animal morphogenesis), GO:0016334 (establishment or maintenance of polarity of follicular epithelium), GO:0048707 (instar larval or pupal morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0060429 (epithelium development), GO:0002168 (instar larval development), GO:0016333 (morphogenesis of follicular epithelium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell)
Protein: Protein kinase, putative (EC 2.7.1.-) (Q57YD1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MLLHYRTLAMATSRKQVVGKYELGKVLASGYFDCRTRICTHIVTGAQYVVRIYSKSTLAEAQWMWDRTRDAIHVMRTLPKHENIIEISELFETESSLYILMQLFAPMHLTKMYTTVGESGQRERVPIQRTKALFLQVVRGLRHMHDCSVVHLGLAPDHVMVNDRDHVKIGNLVSCKYVPKGTKLCRDIRGTMHTVAPEVLRNGEYDPYLADSWSMGVLLYFMLHNGRYPHDGANTTKNILYNRIRPPDPKLPAEALNLLQQLLSHNPGSRMRVEQIADHPFFATEHKDVDTGRTEQQAARYTGVVPNLWASRTAHIPVVLRAPLKERVQYSGNREDAAAYLIQMCYKAFRGRKRRFSDRFLSTQPRGSINRSRSQVVEVVCPSSRSRRRKNYQTPHGDTEAAFGQERTHLSSQHYQQRWSAVTNTEMQQGELGSRTSSINSGFAKCGEGPADPAEGSSFFGFSGSESEGSPMNATQGSHFNFSLKSGNLPLTLPPLRRQGGPCKLGCDPTLDAPVGTPPNSTFDGPDNASPTTASVCNEVVRAASFRLRVPSMLHLKAAEAFSRDLDLRGPGFTHFNTRVDPGRRCPVCDRPPAQRMNRKQPYLNTPYEYKEGKFTIKTVADSD
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [13-288]
- IPR000719: Protein kinase domain (domain) [21-282]
Interaction partners: - glutathione-specific gamma-glutamylcyclotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Axoneme central apparatus protein, putative importin alpha-1 subunit, putative (Q4GYV5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MPNRQIIQVFEEYQRARVKFVQTVADFASKPQHIDALQQAGVMQLLRPLLLDNVPSIQQSAALALGRLANYNEELAESVVSGDILAQLVYSLGDQSRFYKKSAAFVLRSVARHNAQLAQAVVGSQAVEALVGCLEDFDPTVKESAVWALGYVARHNAHLAQEVVDKGAIPPLVLCVQEPELSLKRTAASTLADIAKHLPELAQAVVDQDAVTHLAPLIGSNDGKLKRQVCQCLAQIAKHSVELAELVVEGEIFPRIFSLLKDSDETVRKNASTCIREVAKHTPELAQLIVNAGGVGALVDYTNESTGSARLPGIMTLGYISAFSETLALAVIVSCGIEPLSNALEKEQEDHIKSAAAWSLGQIGRHSADHAKAVADCNVLPKLLDLYLHPSSSDDLRMKSKRALKNIIQRCVQLPALEPLLHPEAPKNVLKYVCGQFAKVLPTDIAAKREFVANRGLATVQRIQPEPGSKLAEYIQSINNCYPPEIVQYYSPQYAQTFLEKIENYHVQQVQQH
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [15-424]
- IPR011989: Armadillo-like helical (homologous_superfamily) [10-433]
- IPR000357: HEAT repeat (repeat) [252-281]
- IPR000225: Armadillo (repeat) [30-409]
Interaction partners: - Importin beta-1 subunit, putative
- Importin-alpha re-exporter protein, putative
- HYDIN/VesB/CFA65-like Ig-like domain-containing protein
- RanBD1 domain-containing protein
- Ran-binding protein 1, putative
- Ribosomal RNA-processing protein 8
- SUMO1/Ulp2, putative
- Dynein arm light chain, axonemal, putative
- Uncharacterized protein
- GTP-binding nuclear protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0007059 (chromosome segregation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)
Protein: Inner membrane protein YjeO (P39284)
Organism: Escherichia coli (strain K12)
Function: Not known
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Sequence: MSARMFVLCCIWFIVAFLWITITSALDKEWMIDGRGINNVCDVLMYLEEDDTRDVGVIMTLPLFFPFLWFALWRKKRGWFMYATALAIFGYWLWQFFLRYQFCL
InterPro domains: - IPR022553: Protein of unknown function DUF2645 (family) [6-103]
Interaction partners: - Uncharacterized protein YjeN
- Inner membrane transporter YjeM
- Elongation factor P--
- D-allose import ATP-binding protein AlsA
- D-allose-binding periplasmic protein
- D-allose kinase
- Linear primary-alkylsulfatase
- Sel1-repeat-containing protein YjcO
- D-allulose-6-phosphate 3-epimerase
- 3-oxo-tetronate 4-phosphate decarboxylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: 6-oxocamphor hydrolase (OCH) (EC 3.7.1.18) (Beta-diketone hydrolase) (Q93TU6)
Organism: Rhodococcus sp
Function: Catalyzes the carbon-carbon bond cleavage of the bicyclic beta-diketone 6-oxocamphor via a retro-Claisen reaction to yield the optically active (2R,4S)-beta-campholinic acid. It is also able to cleave 2,2-disubstituted cyclohexa-1,3-diones such as 2-methyl-2-propylcyclohexa-1,3-dione and 2-methyl-2-butylcyclohexa-1,3-dione which result in racemic keto acid products. Transformations of the bicyclic diketone substrates bicyclo[2.2.1]heptane 2,6-dione and bicyclo[2.2.2]octane-2,6-dione yield (S)-keto acid products.
Sequence: MKQLATPFQEYSQKYENIRLERDGGVLLVTVHTEGKSLVWTSTAHDELAYCFHDIACDRENKVVILTGTGPSFCNEIDFTSFNLGTPHDWDEIIFEGQRLLNNLLSIEVPVIAAVNGPVTNHPEIPVMSDIVLAAESATFQDGPHFPSGIVPGDGAHVVWPHVLGSNRGRYFLLTGQELDARTALDYGAVNEVLSEQELLPRAWELARGIAEKPLLARRYARKVLTRQLRRVMEADLSLGLAHEALAAIDLGMESEQ
InterPro domains: - IPR029045: ClpP/crotonase-like domain superfamily (homologous_superfamily) [8-238]
- IPR001753: Enoyl-CoA hydratase/isomerase (family) [24-237]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0030258 (lipid modification), GO:0006631 (fatty acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0044242 (cellular lipid catabolic process), GO:0043436 (oxoacid metabolic process), GO:0016042 (lipid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0034440 (lipid oxidation), GO:0019395 (fatty acid oxidation), GO:0009062 (fatty acid catabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0006635 (fatty acid beta-oxidation), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: Histone deacetylase 11 (HD11) (EC 3.5.1.98) (Q9GKU5)
Organism: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIEKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRHVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSISAQNSDTPLLPPAVP
InterPro domains: - IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [16-337]
- IPR000286: Histone deacetylase HDAC (family) [139-261]
- IPR044150: Histone deacetylase 11 (domain) [35-319]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [13-320]
- IPR023801: Histone deacetylase domain (domain) [35-316]
Interaction partners: - AT-rich interactive domain-containing protein 4A
- AT-rich interactive domain-containing protein 4B
- Core histone macro-H2A
- Histone H2A
- Histone H2A
- Histone H2A
- Histone H2B
- Nuclear receptor corepressor 1.
- Nuclear receptor corepressor 2.
- Histone H2A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Subtilisin-like protease SBT3.15 (EC 3.4.21.-) (Subtilase subfamily 3 member 15) (AtSBT3.15) (F4JJL8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q84WS0}.
Sequence: MENSFLSSKLVFLLAIALVLFLNTELSFLTAEGASDSNSKVYIVYLGQREHDDPELLTASHHQMLESLLQSKEDAHNSMIYSYQHGFSGFAALLTSSQAKKISEHPEVIHVIPNRILKLKTTRIWDHLGLSPIPTSFSSSSSAKAKGLLHNTSMGSEAIIGVVDSGIWPESKVFNDQGLGPIPKRWRGKCRSGEKFNATMHCNKKLIGAKYYQSGLLAMNGGKFNRIIIRDFKSNRDATGHGTHTATIAGGSFVPNASFYGLARGTVRGGAPRARIASYKACWNVVGWGGICSSADMWKAYDDAIHDQVDVLSVSIGASIPEDSERVDFIAAFHAVAKGITVVAAAGNDGSGAQTICNVAPWLLTVAATTLDRSFPTKITLGNNQTFFVSNLAESLFTGPEISTGLAFLDDDVDVKGKTILEFDSTHPSSIAGRGVVAVILAKKPDDRPAPDNSYIFTDYEIGTHILQYIRTTRSPTVRISAATTLTGQPATPKVAAFSSRGPNSVSPAILKPDIAAPGVSILAAVSPLDPGAFNGFKLHSGTSMSTPVVSGIIVLLKSLHPKWSPAAMRSALVTTAWRTSPSGEPIFAQGSNKKLADPFDYGGGLVNPEKAAKPGLVYDMGIKDYINYMCSAGYNDSSISRVLGKKTKCPIPKPSMLDINLPSITIPNLEKEVTLTRTVTNVGPIKSVYRAVIESPLGITLTVNPTILVFKSAAKRVLTFSVKAKTSHKVNSGYFFGSLTWTDGVHDVTIPVSVKTTISM
InterPro domains: - IPR015500: Peptidase S8, subtilisin-related (family) [155-557]
- IPR034197: Cucumisin-like catalytic domain (domain) [117-578]
- IPR010259: Peptidase S8 propeptide/proteinase inhibitor I9 (domain) [41-119]
- IPR023828: Peptidase S8, subtilisin, Ser-active site (active_site) [542-552]
- IPR000209: Peptidase S8/S53 domain (domain) [155-585]
- IPR041469: Subtilisin-like protease, fibronectin type-III domain (domain) [659-755]
- IPR036852: Peptidase S8/S53 domain superfamily (homologous_superfamily) [12-677]
- IPR037045: Peptidase S8 propeptide/proteinase inhibitor I9 superfamily (homologous_superfamily) [27-120]
- IPR045051: Subtilisin-like protease (family) [42-755]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0045087 (innate immune response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0009682 (induced systemic resistance), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: L-asparagine permease 2 (L-asparagine transport protein 2) (P9WQM7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Dual function in both nitrogen assimilation and in protection against acid stress during infection. Involved in asparagine uptake.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MPPLDITDERLTREDTGYHKGLHSRQLQMIALGGAIGTGLFLGAGGRLASAGPGLFLVYGICGIFVFLILRALGELVLHRPSSGSFVSYAREFYGEKVAFVAGWMYFLNWAMTGIVDTTAIAHYCHYWRAFQPIPQWTLALIALLVVLSMNLISVRLFGELEFWASLIKVIALVTFLIVGTVFLAGRYKIDGQETGVSLWSSHGGIVPTGLLPIVLVTSGVVFAYAAIELVGIAAGETAEPAKIMPRAINSVVLRIACFYVGSTVLLALLLPYTAYKEHVSPFVTFFSKIGIDAAGSVMNLVVLTAALSSLNAGLYSTGRILRSMAINGSGPRFTAPMSKTGVPYGGILLTAGIGLLGIILNAIKPSQAFEIVLHIAATGVIAAWATIVACQLRLHRMANAGQLQRPKFRMPLSPFSGYLTLAFLAGVLILMYFDEQHGPWMIAATVIGVPALIGGWYLVRNRVTAVAHHAIDHTKSVAVVHSADPI
InterPro domains: - IPR004841: Amino acid permease/ SLC12A domain (domain) [27-436]
- IPR004840: Amino acid permease, conserved site (conserved_site) [51-81]
Interaction partners: - L-asparaginase
- Probable conserved membrane protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015174 (basic amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0009067 (aspartate family amino acid biosynthetic process), GO:0006553 (lysine metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0009085 (lysine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)