wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cell division protein DrpB (P76334)
Organism: Escherichia coli (strain K12)
Function: A non-essential division protein that localizes to the septal ring in low ionic strength medium
Subcellular location: Cell inner membrane; Multi-pass membrane protein. Note=Localizes to the septal ring before constriction, only when cells are grown at low ionic strength
Sequence: MEYGSTKMEERLSRSPGGKLALWAFYTWCGYFVWAMARYIWVMSRIPDAPVSGFESDLGSTAGKWLGALVGFLFMALVGALLGSIAWYTRPRPARSRRYE
InterPro domains: - IPR046385: Cell division protein DrpB (family) [8-94]
Interaction partners: - Uncharacterized protein YedJ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0055085 (transmembrane transport), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0071806 (protein transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport), GO:0043952 (protein transport by the Sec complex), GO:0015031 (protein transport), GO:0090150 (establishment of protein localization to membrane), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0051205 (protein insertion into membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Dual specificity protein phosphatase OPG106 (P07239)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Serine/tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the OPG144 protein
Subcellular location: Virion. Host cytoplasm. Note=Approximately 200 molecules of OPG106 are packaged within the virion and are essential for the viability of the virus
Sequence: MDKKSLYKYLLLRSTGDMHKAKSPTIMTRVTNNVYLGNYKNAMDAPSSEVKFKYVLNLTMDKYTLPNSNINIIHIPLVDDTTTDISKYFDDVTAFLSKCDQRNEPVLVHCAAGVNRSGAMILAYLMSKNKESLPMLYFLYVYHSMRDLRGAFVENPSFKRQIIEKYVIDKN
InterPro domains: - IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [68-168]
- IPR052103: Dual Specificity Protein Phosphatases (family) [22-164]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [108-118]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [86-160]
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1-171]
- IPR020422: Dual specificity protein phosphatase domain (domain) [23-171]
- IPR000340: Dual specificity phosphatase, catalytic domain (domain) [34-166]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation), GO:0035335 (peptidyl-tyrosine dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005739 (mitochondrion), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix)
Protein: Early estrogen-induced gene 1 protein (Q78T81)
Organism: Mus musculus (Mouse)
Function: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions. Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downsteam transcription of NFATC1 and activation of PLCG2. Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors. May play a role in estrogen action (By similarity)
Subcellular location: Nucleus. Cytoplasm. Membrane raft
Sequence: MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCIFRVSVRKELKGGKAYSKLGFTDLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSSGGSSSTNSLTGSRPPKTRPTILGSGLPEEPDQSLSSPEEVFHSGHSRNSSYASQQSKLSGYSTEHSRSSSLSDLTHRRNTSTSSSASGGLSMAVEGPEGMEREHRPSEKPPRPPEKPPRPPRPLHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTDGSNTEDSNLRLFVSRDGSTTLSGIQLGNRVSSGVYEPVVIESH
InterPro domains: - IPR039931: EEIG1/2-like (family) [1-391]
- IPR019448: NT-type C2 domain (domain) [2-152]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048839 (inner ear development), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0048568 (embryonic organ development), GO:0042472 (inner ear morphogenesis), GO:0060872 (semicircular canal development), GO:0048562 (embryonic organ morphogenesis), GO:0048752 (semicircular canal morphogenesis), GO:0007423 (sensory organ development), GO:0042471 (ear morphogenesis), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005802 (trans-Golgi network)
Protein: Elongation factor 1-alpha 2 (Q59QD6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis
Subcellular location: Cytoplasm
Sequence: MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYHVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDSVKWDKNRFEEIIKETSNFVKKVGYNPKTVPFVPISGWNGDNMIEPSTNCPWYKGWEKETKSGKVTGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPAGVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKNDPPKGCDSFNAQVIVLNHPGQISAGYSPVLDCHTAHIACKFDTLVEKIDRRTGKKLEENPKFVKSGDAAIVKMVPTKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKSDKAGKVTKAAQKAAKK
InterPro domains: - IPR000795: Translational (tr)-type GTP-binding domain (domain) [5-240]
- IPR004539: Translation elongation factor EF1A, eukaryotic/archaeal (family) [1-444]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [241-332]
- IPR050100: Translation factor GTPase superfamily members (family) [1-443]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-259]
- IPR031157: Tr-type G domain, conserved site (conserved_site) [61-76]
- IPR009001: Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (homologous_superfamily) [335-439]
- IPR004161: Translation elongation factor EFTu-like, domain 2 (domain) [258-324]
- IPR054696: GTP-eEF1A, C-terminal domain (domain) [337-437]
Interaction partners: - Cam1-1p
- Translation elongation factor EF1B gamma
- Tef4p
- Transcription factor SKN7
- Translation elongation factor 1 subunit beta
- Elongation factor 3
- Small ribosomal subunit protein uS5
- Adenylyl-sulfate kinase
- Translation termination factor eRF1
- Small ribosomal subunit protein eS1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall), GO:0030445 (yeast-form cell wall)
Protein: Epithelial splicing regulatory protein 2 (Q7ZVR8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of fgfr2. Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of fgfr2 (By similarity)
Subcellular location: Nucleus
Sequence: MASHSDTLVVFFGATAGANGGKLGSDERELILLVWQIVDLHENKVGKLHRTLVQPDSVDLSEQCKEETGLTAEELCKAEPLESVLQQFHQSVSAELKSLGRSSYTLCVDGPLLIRQVLHPEASKKNLVLPECFYTFVDLKKEFHKCCPNAGPVKDLTLLSMLDYVCIQATVEQEAGLREVKDMVLLILHVLADPYNHKFSAFETVNYKFESGACSKTEAVDSETVIRARGLPWQSSDQDIARFFKGLNIAKGGVALCLNAQGRRNGEALVRFINSEHRDMALDRHKHHMGSRYIEVYKATGEEFLKIAGGTSNEVAQFLSKENQMIIRMRGLPFTATPQDVLGFLGPECPVTDGTEGLLFVKYPDGRPTGDAFVLFACEEYAQNALKKHKQILGKRYIELFRSTAAEVQQVLNRYMSTPLISTLPPPPPPMVSVPVLATPPFITTGNTRDCIRLRGLPYTAAIEDILEFMGEHTIDIKPHGVHMVLNQQGRPSGDAFIQMKSADRAFMVAQKCHKKMMKDRYVEVFQCSTEEMSFVLMGGTLNRSGLSPPPCKLPCLSPPTYAAFPAAPAMLPTEAALYQPPLLATPRTPQAPTHSPAPAFAYYSPQLYMNMNMSYTTYYPSPPVSPSTVSYFAAPPGSVAAAVAAQPTPAILPPQPGALVRMQGLPYNAGVKDILSFFQGYQLQADSVLVLYNWSGQRSGEALVTFPSEKAARRAVAECSNIPLSGHPIHLACCE
InterPro domains: - IPR050666: Epithelial Splicing Regulatory (family) [218-528]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [2-200]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [217-733]
- IPR000504: RNA recognition motif domain (domain) [225-736]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [4-159]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [210-736]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Carboxylesterase 3 (Q6UWW8)
Organism: Homo sapiens (Human)
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics
Subcellular location: Endoplasmic reticulum lumen
Sequence: MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL
InterPro domains: - IPR002018: Carboxylesterase, type B (domain) [33-547]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [30-563]
- IPR050309: Type-B Carboxylesterase/Lipase (family) [26-554]
- IPR019826: Carboxylesterase type B, active site (active_site) [216-231]
Interaction partners: - S-formylglutathione hydrolase
- Hormone-sensitive lipase
- Tumor necrosis factor receptor superfamily member 13C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0044237 (cellular metabolic process), GO:0097006 (regulation of plasma lipoprotein particle levels), GO:0034381 (plasma lipoprotein particle clearance), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0006805 (xenobiotic metabolic process), GO:0071466 (cellular response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Electron transfer flavoprotein regulatory factor 1 homolog (Q9VJG4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (By similarity). May act with the ETF complex to coordinate lipid homeostasis in the fat body in response to stage-specific demands
Subcellular location: Mitochondrion
Sequence: MSQLRSKVISLYKHLQYLGREYPGLNGPQKFRKQIHDAFMNHKDEQDPKKIVALLAQGRYLAKEVEALYSLKKYRSVKQRYSYND
InterPro domains: - IPR052000: Electron transfer flavoprotein regulatory factor 1 (family) [2-83]
- IPR045296: ETFRF1, LYR domain (domain) [5-80]
- IPR008011: Complex 1 LYR protein domain (domain) [7-60]
Interaction partners: - Electron transfer flavoprotein subunit alpha
- Acyl carrier protein, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein FRA10AC1 (Q70Z53)
Organism: Homo sapiens (Human)
Function: May be involved in pre-mRNA splicing
Subcellular location: Nucleus
Sequence: MHGHGGYDSDFSDDERCGESSKRKKRTVEDDLLLQKPFQKEKHGKVAHKQVAAELLDREEARNRRFHLIAMDAYQRHTKFVNDYILYYGGKKEDFKRLGENDKTDLDVIRENHRFLWNEEDEMDMTWEKRLAKKYYDKLFKEYCIADLSKYKENKFGFRWRVEKEVISGKGQFFCGNKYCDKKEGLKSWEVNFGYIEHGEKRNALVKLRLCQECSIKLNFHHRRKEIKSKKRKDKTKKDCEESSHKKSRLSSAEEASKKKDKGHSSSKKSEDSLLRNSDEEESASESELWKGPLPETDEKSQEEEFDEYFQDLFL
InterPro domains: - IPR050645: Histidine Acid Phosphatase (family) [52-265]
- IPR019129: Folate-sensitive fragile site protein Fra10Ac1 (family) [104-219]
Interaction partners: - Zinc finger protein 32
- Spliceosome-associated protein CWC27 homolog
- Splicing factor ESS-2 homolog
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
- Calcium homeostasis endoplasmic reticulum protein
- Leucine-rich glioma-inactivated protein 1
- Splicing factor 3B subunit 2
- Protein Red
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0070603 (SWI/SNF superfamily-type complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome)
Protein: Anthocyanidin 3-O-galactosyltransferase 3GT1 (P0DO58)
Organism: Rhododendron delavayi (Rhododendron) (Rhododendron arboreum subsp
Function: Flavonoid 3-O-glycosyltransferase involved in the biosynthesis of anthocyanins conferring flower red/pink colors, mainly anthocyanidin 3-O-glycosides. Catalyzes the addition of UDP-sugar to the 3-OH of anthocyanidin, with a preference for UDP- galactose (UDP-Gal) as sugar donor and cyanidin as substrate; able to use delphinidin, pelargonidin, peonidin, malvidin and petunidin as substrates in the presence of UDP-Gal. Can also use UDP-glucose (UDP-Glu) as sugar donor with delphinidin, cyanidin and malvidin as substrates, but not active on pelargonidin, peonidin and petunidin
Sequence: MTKNISRDRHVAVLPFPFSSHAGRLLTLVRRLAAAAPNVTFSFYSTPKSIESLFSPAERVPGNVRPYAVPDGVPEGHVFSGEPVEHVNLYLTAVGEGESLRGVLKAAEAETGRRIGCVMSDAFMWFAGDLAEEMGVPWVPFMAGGANSITAHFYTDLIRETVGMHDIVGRENDIVKFIPGFSELRLGDLPTGVLFGNLESPFAIMLHKMGRALPKATAIAINSFEELDPDIIQDLKSKFKMILNVSPFSAISLPSSPPPPPTSYTDEYGCMPWLDNRKAASVAYIGFGTLATPPPVEIAALAEALEASGTPFLWSLKDNPKEFFPEGFIKRTSERQKIVPWAPQEQVLAHGSVGVFVTHCGWNSALESIAAGVPLIGRPFFGDHQLNAWLVENVWKIGVRVEGGVFTKSGTMSALELVLTHEKQKELRARVEMFKKLALKAVGPEQSSTRNLHTLLEIVAGYNL
InterPro domains: - IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [10-435]
- IPR035595: UDP-glycosyltransferase family, conserved site (conserved_site) [341-384]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042440 (pigment metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0046283 (anthocyanin-containing compound metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046148 (pigment biosynthetic process), GO:0009718 (anthocyanin-containing compound biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)