Protein: Hydroxysteroid 11-beta-dehydrogenase 1-like protein (11-beta-hydroxysteroid dehydrogenase type 3) (A0A087WWR3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MANLGTLQLLPPRFKRFSCLSLPNIWITGMPVPATSVPCPSAGPHRTMKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIRQELNVTAAAA
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [72-325]
- IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [212-240]
- IPR051253: 11-beta-hydroxysteroid dehydrogenase (family) [47-331]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [78-254]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016229 (steroid dehydrogenase activity), GO:1901265 (nucleoside phosphate binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0000166 (nucleotide binding), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0042803 (protein homodimerization activity), GO:0017076 (purine nucleotide binding), GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0065008 (regulation of biological quality), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0042445 (hormone metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0009991 (response to extracellular stimulus), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0006140 (regulation of nucleotide metabolic process), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:1901362 (organic cyclic compound biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0043470 (regulation of carbohydrate catabolic process), GO:0032355 (response to estradiol), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0008202 (steroid metabolic process), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0043471 (regulation of cellular carbohydrate catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0014070 (response to organic cyclic compound), GO:0031329 (regulation of cellular catabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0008610 (lipid biosynthetic process), GO:0016042 (lipid catabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1900542 (regulation of purine nucleotide metabolic process), GO:0006706 (steroid catabolic process), GO:0006694 (steroid biosynthetic process), GO:0071392 (cellular response to estradiol stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0008211 (glucocorticoid metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0120178 (steroid hormone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)