wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Dynein light chain roadblock (Q9SWQ6)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR009998}.
Sequence: MVDIAAVDETFKRLQSHKGVLGIIVINAEGIAIRTTFDNDLTVQYAALVSHFTVKARSAVRKLDGDNDLKFLRIRSKKHEIMIAPEFERSHEYYLVVVQDPSREA
InterPro domains: - IPR016561: Dynein light chain roadblock-type 1/2 (family) [3-103]
- IPR004942: Roadblock/LAMTOR2 domain (domain) [7-99]
Interaction partners: - Dynein light chain
- Uncharacterized protein
- Dynein light chain
- Uncharacterized protein
- Dynein light chain
- Mr19,000 outer arm dynein light chain
- Inner arm dynein light chain
- Dynein light chain 9
- Dynein light chain Tctex1
- Dynein light chain roadblock
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0070848 (response to growth factor), GO:0071559 (response to transforming growth factor beta), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071363 (cellular response to growth factor stimulus), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0007179 (transforming growth factor beta receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043228 (non-membrane-bounded organelle), GO:0005858 (axonemal dynein complex), GO:0030286 (dynein complex), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm), GO:0015630 (microtubule cytoskeleton)
Protein: Arabinogalactan endo-beta-1,4-galactanase (EC 3.2.1.89) (Endo-1,4-beta-galactanase) (Galactanase) (P83692)
Organism: Thermothelomyces thermophilus (Myceliophthora thermophila)
Function: Not known
Sequence: ALTYRGVDWSSVVVEERAGVSYKNTNGNAQPLENILAANGVNTVRQRVWVNPADGNYNLDYNIAIAKRAKAAGLGVYIDFHYSDTWADPAHQTMPAGWPSDIDNLSWKLYNYTLDAANKLQNAGIQPTIVSIGNEIRAGLLWPTGRTENWANIARLLHSAAWGIKDSSLSPKPKIMIHLDNGWDWGTQNWWYTNVLKQGTLELSDFDMMGVSFYPFYSSSATLSALKSSLDNMAKTWNKEIAVVETNWPISCPNPRYSFPSDVKNIPFSPEGQTTFITNVANIVSSVSRGVGLFYWEPAWIHNANLGSSCADNTMFSQSGQALSSLSVFQRI
InterPro domains: - IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [2-330]
- IPR011683: Glycosyl hydrolase family 53 (family) [3-331]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0030246 (carbohydrate binding), GO:0016787 (hydrolase activity), GO:0030247 (polysaccharide binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071554 (cell wall organization or biogenesis), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044036 (cell wall macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0016998 (cell wall macromolecule catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044265 (cellular macromolecule catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Allergen Ara h 1, clone P41B (Allergen Ara h I) (allergen Ara h 1) (P43238)
Organism: Arachis hypogaea (Peanut)
Function: Not known
Sequence: MRGRVSPLMLLLGILVLASVSATHAKSSPYQKKTENPCAQRCLQSCQQEPDDLKQKACESRCTKLEYDPRCVYDPRGHTGTTNQRSPPGERTRGRQPGDYDDDRRQPRREEGGRWGPAGPREREREEDWRQPREDWRRPSHQQPRKIRPEGREGEQEWGTPGSHVREETSRNNPFYFPSRRFSTRYGNQNGRIRVLQRFDQRSRQFQNLQNHRIVQIEAKPNTLVLPKHADADNILVIQQGQATVTVANGNNRKSFNLDEGHALRIPSGFISYILNRHDNQNLRVAKISMPVNTPGQFEDFFPASSRDQSSYLQGFSRNTLEAAFNAEFNEIRRVLLEENAGGEQEERGQRRWSTRSSENNEGVIVKVSKEHVEELTKHAKSVSKKGSEEEGDITNPINLREGEPDLSNNFGKLFEVKPDKKNPQLQDLDMMLTCVEIKEGALMLPHFNSKAMVIVVVNKGTGNLELVAVRKEQQQRGRREEEEDEDEEEEGSNREVRRYTARLKEGDVFIMPAAHPVAINASSELHLLGFGINAENNHRIFLAGDKDNVIDQIEKQAKDLAFPGSGEQVEKLIKNQKESHFVSARPQSQSQSPSSPEKESPEKEDQEEENQGGKGPLLSILKAFN
InterPro domains: - IPR006045: Cupin 1 (domain) [175-571]
- IPR011051: RmlC-like cupin domain superfamily (homologous_superfamily) [172-584]
- IPR050253: Seed Storage and Functional Proteins (family) [20-585]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [169-582]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045735 (nutrient reservoir activity)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0044085 (cellular component biogenesis), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0048608 (reproductive structure development), GO:0010431 (seed maturation), GO:0071695 (anatomical structure maturation), GO:0061458 (reproductive system development), GO:0043933 (protein-containing complex organization), GO:0010154 (fruit development), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0070206 (protein trimerization), GO:0070207 (protein homotrimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Putative N-acetyltransferase subunit ARD1 (Q9NFL8)
Organism: Trypanosoma brucei
Function: Not known
Sequence: MQVRRATMEDMYQMQHCNLRCLPENYNLRYYLYHILSWPQLLYVQEDNNGNVVGYVLAKMEEEEHAEKVFGHITSIAVLRTHRRLGIASRVMNAALHEMEHEYDANFCSLHVRKTNDAALHLYQNTLNFRCANVESKYYVDEEDAYHMKRFFKGSNPGFYVTESRQLVRQPNTGAGAAAGSAAEASGQRPDKKNSVDKQKEQLELAAELLEEDLKSSGKGRRQPHQQHQKGGKHGKGKK
InterPro domains: - IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [1-152]
- IPR045047: N-acetyltransferase Ard1-like (family) [1-181]
- IPR000182: GNAT domain (domain) [1-153]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0010467 (gene expression), GO:0031365 (N-terminal protein amino acid modification), GO:0006474 (N-terminal protein amino acid acetylation), GO:0043543 (protein acylation), GO:0006473 (protein acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Acyl-homoserine-lactone synthase (EC 2.3.1.184) (Autoinducer synthesis protein VanI) (P74945)
Organism: Vibrio anguillarum (Listonella anguillarum)
Function: Required for the synthesis of N-(3-oxodecanoyl)-L-homoserine lactone (ODHL), an autoinducer molecule which binds to VanR.
Sequence: MTISIYSHTFQSVPQADYVSLLKLRYKVFSQRLQWELKTNRGMETDEYDVPEAHYLYAKEEQGHLVGCWRILPTTSRYMLKDTFSELLGVQQAPKAKEIYELSRFAVDKDHSAQLGGVSNVTLQMFQSLYHHAQQYHINAYVTVTSASVEKLIKRMGIPCERLGDKKVHLLGSTRSVALHIPMNEAYRASVNA
InterPro domains: - IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [9-188]
- IPR018311: Autoinducer synthesis, conserved site (conserved_site) [24-49]
- IPR001690: Autoinducer synthase (family) [2-192]
Interaction partners: - Transcriptional activator protein VanR
- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
- Methionine adenosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009893 (positive regulation of metabolic process), GO:0035821 (modulation of process of another organism), GO:0044237 (cellular metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031323 (regulation of cellular metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0044003 (modulation by symbiont of host process), GO:0052111 (modification by symbiont of host structure), GO:0052043 (modification by symbiont of host cellular component)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein SMAX1-LIKE 8 (AtSMXL8) (Protein D53-like 3) (AtD53-like 3) (Protein D53-like SMXL 8) (F4IGZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of a transcriptional corepressor complex involved in branching control. Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation. Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds.
Subcellular location: Nucleus {ECO:0000269|PubMed:26546446}.
Sequence: MPTAVNVAKQCLTAEASYALEEAVNVARRRGHSQTTSLHAISALLSLPTSVLRDACARVRNSAYSPRLQFKALDLCLSVSLDRIQSGHQLGSDDSPPVSNSLMAAIKRSQAHQRRLPENFRIYQEMSQSQNQNSLSCVKVELRQLILSILDDPVVSRVFGEAGFRSSELKLSIIRPVPHLLRYSSQQPLFLCNLTGNPEPNPVRWGFTVPSLNFNGDLDYRRISAVFTKDKGRNPLLVGVSAYGVLTSYLNSLEKNQTDGMILPTKLHGLTAVNIGSEISDQISVKFDKTYTDTRFHDLGKLAEQGSGPGLLLHYGDLRVFTNGEGNVPAANYIVNRISELLRRHGRRVWLIGATTSNEVYEKMMRRFPNVEKDWDLQLLTITSLKPCLPHNKSSLIGSFVPFGGFFSTTPSELKLPFSGFKTEITGPVSSISDQTQSTLPPWLQMTTRTDLNQKSSAKVVQTKEGLESVCGNKFTSSASASTCSAKSVTTDLNLRVSSVTTGSGLKKHLDSKDFSQPQSVSSYSFDNPRDLNAESFKIIYRRLTDMVSGQDEAARVISCALSQPPKSVTRRDVWLNLVGPDTVGKRRMSLVLAEIVYQSEHRFMAVDLGAAEQGMGGCDDPMRLRGKTMVDHIFEVMCRNPFCVVFLENIEKADEKLQMSLSKAIETGKFMDSHGREVGIGNTIFVMTSSSQGSATTTSYSEEKLLRVKGRQVEIRIETVSSLPMVRSVYGPTSVNKRKLMGLGNLQETKDTVESVKRLNRTTNGVLDLNLPAQETEIEEKYHCEENSNVWLMNLKNHKRLIEVPFKPFDFEGLAEKIKKSVKENFDKCVRSDCLLEVDPKIIERLLAAVYFSDSRKDIKELLENIMSPVFLRIKERYEITTSCVVKLVGRDLDIFLEDQMDLFFVKSQ
InterPro domains: - IPR036628: Clp, N-terminal domain superfamily (homologous_superfamily) [10-175]
- IPR051650: Strigolactone signaling regulator (family) [1-868]
- IPR003959: ATPase, AAA-type, core (domain) [577-700]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [519-890]
- IPR004176: Clp, repeat (R) domain (domain) [7-179]
Interaction partners: - F-box protein MAX2
- Probable esterase KAI2
- Strigolactone esterase D14
- Carotenoid cleavage dioxygenase 8, chloroplastic
- Carotenoid cleavage dioxygenase 7, chloroplastic
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD2
- Cytochrome P450 711A1
- ATP-dependent Clp protease adapter protein CLPS1
- Topless-related protein 2
- F-box/kelch-repeat protein SKIP25
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: PGL/p-HBAD biosynthesis glycosyltransferase Rv2957 (EC 2.4.1.-) (P9WMX7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in glycosylation steps downstream of mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (mycoside B) during the p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Sequence: MAAPMFSIIIPTLNVAAVLPACLDSIARQTCGDFELVLVDGGSTDETLDIANIFAPNLGERLIIHRDTDQGVYDAMNRGVDLATGTWLLFLGADDSLYEADTLARVAAFIGEHEPSDLVYGDVIMRSTNFRWGGAFDLDRLLFKRNICHQAIFYRRGLFGTIGPYNLRYRVLADWDFNIRCFSNPALVTRYMHVVVASYNEFGGLSNTIVDKEFLKRLPMSTRLGIRLVIVLVRRWPKVISRAMVMRTVISWRRRR
InterPro domains: - IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [1-219]
- IPR001173: Glycosyltransferase 2-like (domain) [7-128]
Interaction partners: - Conserved protein
- GDP-L-fucose synthase
- PGL/p-HBAD biosynthesis glycosyltransferase Rv2958c
- Uncharacterized MFS-type transporter Rv2994
- Probable sugar transferase
- Uncharacterized protein Rv1520
- Conserved protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0035250 (UDP-galactosyltransferase activity), GO:0008378 (galactosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1903509 (liposaccharide metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0009247 (glycolipid biosynthetic process), GO:0006664 (glycolipid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Right handed beta helix domain-containing protein (Q388V9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MTEATNEGCLTPSWNVSSVRIAFANFMESAPSLLTTHASPATLPAELKKIAGSQSFRVCLQNGDYGQSYIKNGAPCLIMGAAPPAASTDGESADSRKESRGDSGRSLWSVFKQPVKIDAHSLIVFKCVWFANRVEVTGDGPVFFNECMFGAAAQRVHRGISSTESFASVHVSATNLCAFSECEFVHNCGSAADVGGSEIPVLLGSGRATLNVHNSSFLGSGVASTAMMLTDNASLEVENVSVSRCSGHSLIVSDTSSAVVFRSVFSQNSGSIWVRNQGSLEIRDSSLEAVYGGRSNLVLTEKGRCTSHGCTISATATSGFSSGRSLVVARDKAHLSLDTCELFWVNEKGLPEGRCKLPLKVPISGHDRDQLDELGLFLVMLMECSEGTFTRCLLRLPLVEEEGGWCAAVGVLLRSVPRVNTFPLYAVQNSVVYDREWGKRTPTKGKSSATADSQCMWGLVLPYTSDYRHAPDLQQLKSMWTETNHFFEGTGERLKDIAQAVTTYEVYCRATGRSPSMFHADNHENLPSFSTNSYTKEGDFSIVNHPSLENTSPPPASMAEKKPDQEEGTGNKQAQSEDHLRSSVRRTNEDGINSSSTSLTSYGDDEEENNDPSNPPTRRGSPVSVRAKPKNPSNGAASLQTEGKKHSNIVDDADVRQDTVLKEKHRQGNEMSPTANGLVSMPPIFVRAPEEPAAKGHSVSVANGQQNSDRQSGTRGSLQITNLRSLEKRESGRKGERSPNFLDGGSAPSVPRTRNNPVSKKRYKQFNGEKDISMHSDGLLLTCFTPCSASPPRRASSSVGIGELCTHKYYNNVSSASDMKPWDVRTAREMAGRGFELGKNGTYSKVSKGQAESVWDEEENFNYANGLSYASTDKDSSSVSRSRRYNATGSYNGKTYKSFTSARGGLGFHVRRVQSGHADDATARLYDEFLRKWKTTQHFSELLDELRNDQRRRERLSREAMERQAERLHSMGLQTRCERHSPQVAGSGRNYALQRRNEQRLRTNDDTTNDSTAGLCTPESVRRPAHANTTVNSEVVKRRAENGGESSCGGKSPSETVTASDKTPETKQARKGKKRGHTKRKRRKQKH
InterPro domains: - IPR011050: Pectin lyase fold/virulence factor (homologous_superfamily) [134-315]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0097014 (ciliary plasm)
Protein: Aldose reductase A (ARA) (EC 1.1.1.21) (Aldehyde reductase A) (AlrA) (Q6IMN8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Probably affects several metabolic pathways in addition to converting glucose to sorbitol. Affects group size.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14551196}.
Sequence: MEPSFKLSSGHKIPLVGFGTWKAETTLVGKAVEVALDAGYRHIDCAAVYLNEKEVGEAFTKKFTTEATVKREDVFITSKLWNTFHKKEHVRPALERTLSDLGLQYLDLYLVHWPVAFEYTSNDIQTSGSTQEFVSIRETWEEMEKLVDAGLVKSIGLSNFNVQGLMEVLSYARIKPAANQVELHPFLSQPELKKFCDKHNIHLTAYSPLGNGAFVDNEEVGAIAKKYNKTIPNVLCKWAIQKNFSVIPKSSTPSRVAENFDLFNFEIEEADMLFLDKMDKNLRTCDPAKFWGVPLFN
InterPro domains: - IPR018170: Aldo/keto reductase, conserved site (conserved_site) [39-160]
- IPR036812: NAD(P)-dependent oxidoreductase domain superfamily (homologous_superfamily) [1-295]
- IPR020471: Aldo-keto reductase (family) [1-296]
- IPR023210: NADP-dependent oxidoreductase domain (domain) [16-278]
Interaction partners: - Aldehyde dehydrogenase
- Aldehyde dehydrogenase
- Putative aldehyde dehydrogenase family 7 member A1 homolog
- Dihydropteridine reductase
- dihydrofolate reductase
- Sepiapterin reductase
- Probable glycerol kinase
- Aldose reductase C
- Beta-galactosidase 1
- Probable alpha-galactosidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006970 (response to osmotic stress), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)
Protein: Probable periplasmic serine endoprotease DegP-like (EC 3.4.21.107) (Protease Do) (Q57155)
Organism: Pseudomonas aeruginosa
Function: Not known
Subcellular location: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
Sequence: MHTLKRCMAAMVALLALSLAMTARAELPDFTPLVEQASPAVVNISTRQKLPDRAMARGQLSIPDLEGLPPMFRDFLERSIPQVPRNPRGQQREAQSLGSGFIISNDGYILTNNHVVADADEILVRLSDRSEHKAKLIGADPRSDVAVLKIEAKNLPTLKLGDSNKLKVGEWVLAIGSPFGFDHSVTAGIVSAKGRSLPNESYVPFIQTDVAINPGNSGGPLLNLQGEVVGINSQIFTRSGGFMGLSFAIPIDVALNVADQLKKAGKVSRGWLGVVIQEVNKDLAESFGLDKPSGALVAQLVEDGPAAKGGLQVGDVILSLNGQSINESADLPHLVGNMKPGDKINLDVIRNGQRKSLSMAVGSLPDDDEEIASMGAPGAERSSNRLGVTVADLTAEQRKSLDIQGGVVIKEVQDGPAAVIGLRPGDVITHLDNKAVTSTKVFADVAKALPKNRSVSMRVLRQGRASFITFKLAE
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [252-474]
- IPR001940: Peptidase S1C (family) [107-322]
- IPR011782: Peptidase S1C, Do (family) [28-470]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [6-279]
- IPR001478: PDZ domain (domain) [261-468]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042597 (periplasmic space)