Protein: (+)-epi-alpha-bisabolol synthase (EC 4.2.3.138) (Terpene synthase 8) (LdTPS8) (J7LH11)
Organism: Phyla dulcis (Aztec sweet herb) (Lippia dulcis)
Function: Sesquiterpene synthase involved in the biosynthesis of (+)-epi-alpha-bisabolol, a precursor of the natural sweetner hernandulcin.
Sequence: MNSTSRRSANYKPTIWNNEYLQSLNSIYGEKRFLEQAEKLKDEVRMLLEKTSDPLDHIELVDVLQRLAISYHFTEYIDRNLKNIYDILIDGRRWNHADNLHATTLSFRLLRQHGYQVSPEVFRNFMDETGNFKKNLCDDIKGLLSLYEASYLLTEGETIMDSAQAFATHHLKQKLEENMNKNLGDEIAHALELPLHWRVPKLDVRWSIDAYERRQDMNPLLLELAKLDFNIAQSMYQDELKELSRWYSKTHLPEKLAFARDRLVESYLWGLGLASEPHHKYCRMMVAQSTTLISIIDDIYDVYGTLDELQLFTHAVDRWDIKYLEQLPEYMQICFLALFNTVNERSYDFLLDKGFNVIPHSSYRWAELCKTYLIEANWYHSGYKPSLNEYLNQGLISVAGPHALSHTYLCMTDSLKEKHILDLRTNPPVIKWVSILVRLADDLGTSTDELKRGDNPKSIQCHMHDTGCNEEETRAYIKNLIGSTWKKINKDVLMNFEYSMDFRTAAMNGARVSQFMYQYDDDGHGVPEGKSKERVCSLIVEPIPLP
InterPro domains: - IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [12-217]
- IPR005630: Terpene synthase, metal-binding domain (domain) [250-487]
- IPR001906: Terpene synthase, N-terminal domain (domain) [15-191]
- IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [13-543]
- IPR034741: Terpene cyclase-like 1, C-terminal domain (domain) [217-544]
- IPR050148: Terpene synthase-like (family) [2-543]
- IPR044814: Terpene cyclases, class 1, plant (family) [6-542]
- IPR036965: Terpene synthase, N-terminal domain superfamily (homologous_superfamily) [52-217]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016838 (carbon-oxygen lyase activity, acting on phosphates), GO:0010333 (terpene synthase activity), GO:0010334 (sesquiterpene synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0045338 (farnesyl diphosphate metabolic process), GO:0051761 (sesquiterpene metabolic process), GO:0006721 (terpenoid metabolic process), GO:0046246 (terpene biosynthetic process), GO:0051762 (sesquiterpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)