Protein: Antileukoproteinase (ALP) (Secretory leukocyte protease inhibitor) (P97430)
Organism: Mus musculus (Mouse)
Function: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the innate immune response after bacterial infection. Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity. Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:18322212, ECO:0000269|PubMed:9126337}.
Sequence: MKSCGLLPFTVLLALGILAPWTVEGGKNDAIKIGACPAKKPAQCLKLEKPQCRTDWECPGKQRCCQDACGSKCVNPVPIRKPVWRKPGRCVKTQARCMMLNPPNVCQRDGQCDGKYKCCEGICGKVCLPPM
InterPro domains: - IPR008197: WAP-type 'four-disulfide core' domain (domain) [29-131]
- IPR050514: WAP four-disulfide core domain (family) [6-128]
- IPR036645: Elafin-like superfamily (homologous_superfamily) [28-130]
Interaction partners: - Neutrophil elastase
- Progranulin
- Myeloblastin
- Lactotransferrin
- Cathepsin G
- Neutrophil gelatinase-associated lipocalin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048525 (negative regulation of viral process), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0045069 (regulation of viral genome replication), GO:0045071 (negative regulation of viral genome replication), GO:0051098 (regulation of binding), GO:1903900 (regulation of viral life cycle), GO:0043207 (response to external biotic stimulus), GO:0044092 (negative regulation of molecular function), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0098542 (defense response to other organism), GO:0019730 (antimicrobial humoral response), GO:0043393 (regulation of protein binding), GO:0051100 (negative regulation of binding), GO:0042742 (defense response to bacterium), GO:0019731 (antibacterial humoral response), GO:0032091 (negative regulation of protein binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)