Protein: Epithelial sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (Gamma-ENaC) (Amiloride-sensitive sodium channel subunit gamma) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG) (Q9WU39)
Organism: Mus musculus (Mouse)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Subcellular location: Apical cell membrane {ECO:0000305|PubMed:10409305}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51170}.
Sequence: MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRIVVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKDWWARRRTPPSTETPSSQQGQDNPALDTDDDLPTFTSAMRLPPAPEAPVPGTPPPRYNTLRLDSAFSSQLTDTQLTNEF
InterPro domains: - IPR020903: Epithelial sodium channel, conserved site (conserved_site) [395-415]
- IPR004724: Epithelial sodium channel, chordates (family) [24-636]
- IPR001873: Epithelial sodium channel (family) [24-569]
Interaction partners: - Epithelial sodium channel subunit beta
- E3 ubiquitin-protein ligase NEDD4-like
- Epithelial sodium channel subunit alpha
- E3 ubiquitin-protein ligase NEDD4
- Protein unc-80 homolog
- Solute carrier family 12 member 1-chloride cotransporter 1)
- Cystic fibrosis transmembrane conductance regulator
- Serine/threonine-protein kinase Sgk1
- Sodium/hydrogen exchanger 3
- Sodium channel protein type 5 subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0019904 (protein domain specific binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0050699 (WW domain binding), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0015280 (ligand-gated sodium channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0050801 (monoatomic ion homeostasis), GO:0001666 (response to hypoxia), GO:0048729 (tissue morphogenesis), GO:0009611 (response to wounding), GO:0098660 (inorganic ion transmembrane transport), GO:0070482 (response to oxygen levels), GO:0071495 (cellular response to endogenous stimulus), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0055082 (intracellular chemical homeostasis), GO:0098739 (import across plasma membrane), GO:1901698 (response to nitrogen compound), GO:0009888 (tissue development), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:1902074 (response to salt), GO:0016477 (cell migration), GO:0098655 (monoatomic cation transmembrane transport), GO:0071417 (cellular response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1902075 (cellular response to salt), GO:1901699 (cellular response to nitrogen compound), GO:0044319 (wound healing, spreading of cells), GO:0002009 (morphogenesis of an epithelium), GO:0099587 (inorganic ion import across plasma membrane), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0042060 (wound healing), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0055080 (monoatomic cation homeostasis), GO:0055078 (sodium ion homeostasis), GO:0036293 (response to decreased oxygen levels), GO:0014070 (response to organic cyclic compound), GO:0060429 (epithelium development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0006812 (monoatomic cation transport), GO:0090505 (epiboly involved in wound healing), GO:0098659 (inorganic cation import across plasma membrane), GO:0035725 (sodium ion transmembrane transport), GO:0071407 (cellular response to organic cyclic compound), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0035313 (wound healing, spreading of epidermal cells), GO:0006883 (intracellular sodium ion homeostasis), GO:0098719 (sodium ion import across plasma membrane), GO:0030001 (metal ion transport), GO:0090504 (epiboly), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0009897 (external side of plasma membrane), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0034703 (cation channel complex), GO:0034706 (sodium channel complex)