Protein: Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (Silica-induced gene 41 protein) (SIG-41) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B) (P62996)
Organism: Mus musculus (Mouse)
Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:28785060}.
Sequence: MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMSTRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRGFAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRRRDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRSRSRSRSYSPRRY
InterPro domains: - IPR050441: RNA-binding motif (family) [115-283]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [88-211]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [2-203]
- IPR000504: RNA recognition motif domain (domain) [118-196]
Interaction partners: - Serine/arginine-rich splicing factor 3
- Serine/arginine-rich splicing factor 7
- Serine/arginine-rich splicing factor 1
- Serine/arginine-rich splicing factor 9
- Serine/arginine-rich splicing factor 2
- Serine/arginine-rich splicing factor 10
- Heterogeneous nuclear ribonucleoproteins A2/B1
- Serine/arginine-rich splicing factor 6
- Heterogeneous nuclear ribonucleoproteins C1/C2
- Serine/arginine-rich splicing factor 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010628 (positive regulation of gene expression), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing), GO:1903311 (regulation of mRNA metabolic process), GO:0033120 (positive regulation of RNA splicing), GO:1903313 (positive regulation of mRNA metabolic process), GO:0048026 (positive regulation of mRNA splicing, via spliceosome), GO:0050684 (regulation of mRNA processing), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0050685 (positive regulation of mRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)