Protein: Mevalonate kinase (MK) (EC 2.7.1.36) (Q86AG7)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MISNQDNIIQVSAPGKIILFGEHAVVLEKTAIASALSLRTTVTFTPNTNNTLLLDFPDLAGFGVREWSLDEFKKLDHFPNDIDILKPIECSELFQQELNKIIDIKGIHTFLFLFCALTKCTKAYNIKITSDLPIGAGLGSSASFCVSICAGLLKAFDTYICGGCKQCIGGQGQQQQICNEQLNLINLWSLQGEKIMHGTPSGIDNAVATFGKALTFTRKNGYKILENGIPPLRILITNTRVSRSTKTLVEGVIQRSKLYPTLIDPVSNLIDTISSQCIESFNQYHTDKDYEKLQQTMDLMFDMNQHLLSGCYGVGHSSIDTIVSITKSLGFHTKLTGAGGGGCVITLLKQDTTIDQLSNLKLTLSSNGFESWEATIGDPGVSINILPIQK
InterPro domains: - IPR013750: GHMP kinase, C-terminal domain (domain) [289-357]
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [11-381]
- IPR006203: GHMP kinase, ATP-binding, conserved site (conserved_site) [132-143]
- IPR006205: Mevalonate kinase (family) [9-384]
- IPR006204: GHMP kinase N-terminal domain (domain) [119-211]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [6-220]
- IPR036554: GHMP kinase, C-terminal domain superfamily (homologous_superfamily) [229-384]
Interaction partners: - Diphosphomevalonate decarboxylase
- phosphomevalonate kinase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
- Probable acetyl-CoA acetyltransferase
- GMP synthase
- Farnesyl diphosphate synthase
- hydroxymethylglutaryl-CoA lyase
- Acetyl-CoA C-acyltransferase
- 2-Hydroxyacid oxidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0044262 (cellular carbohydrate metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0006020 (inositol metabolic process), GO:0046165 (alcohol biosynthetic process), GO:0019751 (polyol metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0046173 (polyol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)