Protein: AMP deaminase, putative (Q386C9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MGQRWHDILIAGDEGDRSFSDAAPFVVEALEIIFHTRLLHSGVGVECDSAELSTIKDDHLAFRVARKDVEALRGMMATLLESAHDSLLTLQAADILPDDSAENAVNPGRSLLSCDRGLVSPRILKLNPFLRSHPTFDYKVFRAKFERLCQIVADARLFSACEPRVKILQSRYRLYRAFNMRREEHFHPTLGPGNLRRAPKTDVRRVGTCMSASSVVDFVQKTVSNEPNLVLSTSSVLSTATDKGRARNPIGRGFTSEVQLAVPQQTFSMPTKDSGTHDSTGERTVTLKALADAFFGPSLPPQDRVFTMEGLGLRLSSSKTTSHTVDILEARNEHHTAANAVPILRQFLDVYSGNGGALLGRLVTPMISRISRNKKDVLEVEFTVTGHRPGEVQHIASWCVRTGFFASGGNWPSLRITMRPSAGDGGECTAKSMEDVLKHIFEPIWLALLCPEKYPDVAQLFRRLVSVSVLVSGEAGVQEMPTEGDPAMYSVEKGDMPPSSFFIYHVWRNVQLLNCFIATHVVSSLSAKEPPTSTTEDVKVEFGNSTAHPSHVQRPLFQRYEPLKRQPLRFRLYTSGTRKKTFVETVIGLLVTDQVVGPLEVLAWSSLTYFYYLTQRSIVVTPYHTYDSTPYSMLKRAIPFAVETGLRVSVSTIDPLYFHTNEEALNEELNGIMKIHQVSTPEVMEICLNSAGYINFDIEKRCKFIGGPWRRVSAQNNNFTVTQVNSLRLRFRELSLTHEMDLLFRKGLTKWGGHSESKRLSEDFLVHGGWSLLATGSSASTSAERRRENLWRFFDIPPLPEKVSGAMTMPGSGRRLFVDKLIKFPRIVVLGPRGRKRSEARCVVEALQRREYYKAFTVHYELAAPLASLAGTAGVEALLASQRSSRSSGRGFTSTEKWREHHDKGEQTQQPSTRASGNISSSIRSFSSPVVREQGVTVPTTFCFRDGVRDVVVPANANATTKEYFRPLPSWAKFQADARQLRALSSDSSMLRYANRRLDMLECKFNLHVALTNDDQETQEGHLTDMLREKSDIYKCVKVDVHCHMASGMTAKELLKFIKEKVRMNRNDVVDIDRSTGFPITLGELFAKIHAEKLSGTTFDVEDLTIASLNVKAGKATFNRFDVFNGRYSPLGQSALRSLLLKTDNFIGGRYFAELIRTVFDRQAADGYSFSEYRLSIYGRCHDEWDRLSRWFLTHDMLHPTNRWIVQVPRLYGIYRQNKILSSFEDLLTNIFLPLWQASIDPEKHPFLNYFLAHVSGFDLVDNESERETDSLINTSPSQWTSVENPPFMYWLYYMWANITSLNRYRAARGLTTFSLRPHAGESGDPGHMAEAFLVADGVNHGINLKDTPVLQYLYYLGQIPLGITPLSNNALFCRYNENPFALFFRRGLNVALSTDGALIFHHTEEPLIEEYSTAANYWNLSQVDLCEIAKNSVLMSGFPSYRKKKWLGELYALRSAVGNDMRLTRVPQSRCTFRYEVYLEELSYLEAVASKEVSPSQIMTWQLEGLYTMTTLGLTRDEVMKQRLKNQGVGEYASPVESRTKATTVLTGPIIVAPSRL
InterPro domains: - IPR032466: Metal-dependent hydrolase (homologous_superfamily) [21-1486]
- IPR006329: AMP deaminase (family) [354-1493]
Interaction partners: - Bifunctional dihydrofolate reductase-thymidylate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0019239 (deaminase activity), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009126 (purine nucleoside monophosphate metabolic process), GO:0009167 (purine ribonucleoside monophosphate metabolic process), GO:0046040 (IMP metabolic process), GO:0046037 (GMP metabolic process), GO:0006163 (purine nucleotide metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0099080 (supramolecular complex), GO:0097740 (paraflagellar rod), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium)