Protein: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein (Cnt-b) (Centaurin-beta) (A2ADA6)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Endosome membrane {ECO:0000256|RuleBase:RU369028}; Peripheral membrane protein {ECO:0000256|RuleBase:RU369028}.
Sequence: MTVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFVSGVRDLSQQCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRSVRQQLHNFVKEDVRKFKETKKQFDKVREDMELSLVRNAQAPRHRPHEVEEATGALTVTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRDFSYDEPKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSTTDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQCEGPGVRKPTASSSRQDKEAWIKDKYVEKKFLRKLTSAPAREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAALSSAATMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRELHPGLLAHQAARTRDLPALAAALAHGAEVNWADAADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREAEAPPGQPGPLPGSSPTELQYRRCIQEFIGLHLEES
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [264-361]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-287]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [662-800]
- IPR045258: ArfGAP ACAP1/2/3-like (family) [4-800]
- IPR001164: Arf GTPase activating protein (domain) [399-521]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [400-516]
- IPR002110: Ankyrin repeat (repeat) [667-761]
- IPR042695: ACAP3, BAR domain (domain) [16-215]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [259-370]
- IPR004148: BAR domain (domain) [3-236]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [381-520]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016477 (cell migration), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:0001764 (neuron migration), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0048699 (generation of neurons), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030427 (site of polarized growth), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0030426 (growth cone), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)