Protein: Exocyst complex component EXO70A1 (AtExo70a1) (Exocyst subunit Exo70 family protein A1) (Q9LZD3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall. Participates in polarized pectin delivery required for the polarized development of the mucilage-producing volcano cells of the seed coat. Involved in the recycling and localization of auxin efflux carriers PIN1 and PIN2, and thus in polar auxin transport regulation. Functions in vesicle trafficking in tracheary elements to regulate patterned secondary cell wall (SCW) thickening.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:19895414}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000269|PubMed:20870962}. Cell membrane {ECO:0000269|PubMed:23163883}. Secreted, cell wall {ECO:0000269|PubMed:20870962}. Note=During cytokinesis, localizes to the nascent cell plate and later to the cell plate insertion site and along the post-cytokinetic wall (PubMed:20870962). Localized at vesicle-like small compartments at cortical microtubules, especially in the presence of FPP3/VETH1, FPP2/VETH2 and COG2 (PubMed:25541219). Confined to helical/annular plasma membrane (PM) domains in protoxylem of roots before the secondary cell wall (SCW) is deposited. After the induction of xylem differentiation, first associated with plasma membrane (PM) foci and later co-localizes with microtubules (MT) organized into regular bundles, especially at the cell cortex (PubMed:27801942). {ECO:0000269|PubMed:20870962, ECO:0000269|PubMed:25541219, ECO:0000269|PubMed:27801942}.
Sequence: MAVDSRMDLLSERAVLMRASLQKSQTITDNVVSILGSFDSRLSALETAMRPTQIRTHAIRKAHENIDRTLKAAEVILSQFDLLRQAETKVLKGPHEDLESYLDAIAQLRKIIRYFMSNKSFKSSDGVLNHANSLLAKAQSKLEEEFKQLLASYSKAVEPDRLFDGLPNSLRPSSDGDGGGKPHGGHHNDDAETAAYTLPILIPSRVLPLLHDLAQQMVQAGHQQQLLQIYRDTRSFVLEESLKKLGVEKLSKEDVQRMQWEVLEAKIGNWIHFMRIAVKLLFAGERQVCDQIFRGFDSLSDQCFAEVTVSSVSMLLSFGDAIARSKRSPEKLFVLLDMYEIMRELHTEIETIFKGKACLEIRDSATGLTKRLAQTAQETFGDFEEAVEKDATKTAVLDGTVHPLTSYVINYVKFLFDYQTTLKQLFLEFGNGDDSNSQLASVTMRIMQALQNNLDGKSKQYKDPALTHLFLMNNIHYMVRSVRRSEAKDLLGDDWVQRHRRIVQQHANQYKRVAWTKILQSSSAQGLTSSGGGSLEGGNSSGVSRGLLKERFKMFNMQFDELHQRQSQWTVPDTELRESLRLAVAEVLLPAYRSFLKRFGPLVESGKNPQKYIKYTAEDLERLLGELFEGKSMNEPRR
InterPro domains: - IPR004140: Exocyst complex component Exo70 (family) [55-630]
- IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [76-629]
- IPR046364: Exocyst complex subunit Exo70, C-terminal (domain) [269-625]
Interaction partners: - Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC3A
- Exocyst complex component EXO84B
- Exocyst complex component SEC10a
- Exocyst complex component SEC15B
- Exocyst complex component SEC5A
- Exocyst complex component SEC5B
- Protein ROH1A
- Exocyst complex component EXO84C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0140352 (export from cell), GO:0051234 (establishment of localization), GO:0032940 (secretion by cell), GO:0006810 (transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030427 (site of polarized growth), GO:0042995 (cell projection), GO:0060187 (cell pole), GO:0035838 (growing cell tip), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0090406 (pollen tube)