Protein: Phospholipid-transporting ATPase (EC 7.6.2.1) (Q386H6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
Sequence: MAEDAAPDTSHQSSNTSDEGGAKSEVIVHMNNREANEEYGYPNNFIKTSHYTALSFLPLGLIAQFMRVSNFYFLVCMCLTLIPGLSPVNPVTAILPLLFVIGVSLAKEGVEEFRRHTADRLANSVEVDVLINGVMQRVPSRDIRVGDIVRVSNGEEVRADLLCLSTSDEEDQVYIDMCNLDGETSLKNRKPHEHTASLRTPEQLQEAQVKIVTTQPDAELHSWSGCIESNGEAFAVDIGNFLCRGSVLRKTDWVWGVVVYAGVDTKMFRNLKGHPMKMSDLDRRLNVMIVALLLFKCVVLATLAFLLVWWNRNNKEHIWYLHWYMNQYGSTVLLLRSFVTIFLLLSYFIPISLFVTIEVCKVIQAYWMVADGKMTDVVNGRLCRCRPNTSNLNEQLAMVRFIFTDKTGTLTENVMKFKQGDFQGFRLDSACGTKPTDLLDRCNPAREAAYEYFLSIALCNTVQPTEDPNAEGGISYDGTSPDEVALVSMAAEHGFRLKKRTTREMVLDIEGVEHEYRILATLEFTPERKMMSIIVRDNVSHHIVLFTKGADSSLLPRTCTNRQAQNYVQKLRGTLQDMSVCGLRTLVIGRRFLLPEEYKNWEDSYKTASRTLIDRSAALDDVCMRIEGDLWPVGATAIEDKLQQEVPETISFFLEAGVVIWMLTGDKRETAVTVAATAKLCDPQKDSIIHIDIGSFDPKSAEAIRKVDSDLSKVRRTLESGGENGSKCTIVIDGLALGVAMSEHFLTFLDLSMRVNSAVCCRLTPLQKAEVVRMFQGSTGLTAIAIGDGANDVSMIQEGRVGVGIIGLEGSQAALSADYAIPRFRHLRRLCAVHGRYSLVRNSGCIMISFYKNAVLGMMMILFCFHSAFSGGTLFDGWLLTFFNILLTSIPPFFLGVFDKDLPEDALLRRPHLFTQLSHGLYFDVMTTVRWFGEALIHGTLIFYLFYLTIRNLDWSTHNISMIELGTMQIFIVVLVVLVRCGLAVRCWRSLQLLGLLASLAITLALTLTYSSFKSVGGSSIYWQMFDLALGPKFWLYMLLVLGSLIMINLSVLYFQKRRYPTLRDTADEENRVMCRGSLLDENVSQGDKAGYVTFGVESTQSSDREDKSIDIQDMRRREIEAGDTLHG
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [126-270]
- IPR001757: P-type ATPase (family) [758-867]
- IPR032630: P-type ATPase, C-terminal (domain) [814-1062]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [399-635]
- IPR036412: HAD-like superfamily (homologous_superfamily) [398-841]
- IPR006539: P-type ATPase, subfamily IV (family) [443-1066]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [387-837]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [405-411]
- IPR023214: HAD superfamily (homologous_superfamily) [636-824]
- IPR032631: P-type ATPase, N-terminal (domain) [28-94]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [41-1060]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0140326 (ATPase-coupled intramembrane lipid transporter activity), GO:0005319 (lipid transporter activity), GO:0140303 (intramembrane lipid transporter activity), GO:0005548 (phospholipid transporter activity), GO:0140327 (flippase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:0061024 (membrane organization), GO:0015914 (phospholipid transport), GO:0120009 (intermembrane lipid transfer), GO:0015748 (organophosphate ester transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0020016 (ciliary pocket), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)