Protein: Histamine-gated chloride channel subunit (A1KYB5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MVFQIIILVICTICMKHYAKGEFQQSLAITDILPEDIKRYDKMRPPKKEGQPTIVYFHVTVMGLDSIDENSMTYVADVFFAQTWKNHRLRLPENMTQEYRLLEVDWLKNMWRPDSFFKNAKSVTFQTMTIPNHYMWLYKDKTILYMVKLTLKLSCIMNFAIYPHDTQECKLQMESLSHTTDDLIFQWDPTTPLVVDENIELPQVALIRNETADCTQVYSTGNFTCLEVVFTLKRRLVYYVFNTYIPTCMIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQSSLPPVSYLKAVDAFMSVCTVFVFMALMEYCLINIVLSDTPIPKPMAYPPKPVAGDGPKKEGEGAPPGGSNSTASKQQATMLPLADEKIEKIEKIFDEMTKNRRIVTTTRRVVRPPLDADGPWIPRQESRIILTPTIAPPPPPPQPAAPEPELPKPKLTPAQERLKRAIYIDRSSRVLFPALFASLNGIYWCVFYEYL
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [234-484]
- IPR006201: Neurotransmitter-gated ion-channel (family) [6-352]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [20-235]
- IPR006028: Gamma-aminobutyric acid A receptor/Glycine receptor alpha (family) [239-481]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [155-169]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [237-482]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [243-333]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [37-235]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0005253 (monoatomic anion channel activity), GO:0005254 (chloride channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0009605 (response to external stimulus), GO:0007267 (cell-cell signaling), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0009266 (response to temperature stimulus), GO:0043052 (thermotaxis), GO:1901700 (response to oxygen-containing compound), GO:0099536 (synaptic signaling), GO:0030534 (adult behavior), GO:0010033 (response to organic substance), GO:0006810 (transport), GO:0009636 (response to toxic substance), GO:0045472 (response to ether), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0099537 (trans-synaptic signaling), GO:0006821 (chloride transport), GO:0098916 (anterograde trans-synaptic signaling), GO:0006820 (monoatomic anion transport), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex)