Protein: Mitogen-activated protein kinase kinase kinase 9 (MAP kinase kinase kinase 9) (EC 2.7.11.24) (MAPK/ERK kinase kinase 2) (AtMEKK2) (Protein SUPPRESSOR OF MKK1 MKK2 1) (O81472)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Triggers SUMM2-mediated immune responses, including cell death and defense responses. Probably inhibited by the MEKK1-MKK1/ MKK2-MPK4 kinase cascade to adjust plant defense. Seems to contribute in transducing external glutamate (L-Glu) signal that elicits large-scale changes in root architecture.
Sequence: MKKSSDKSPVRQHDTATQINSDAVSSSTSFTDSDSTCSFLTPSMEFPDRISFRRIDFSEAAPTGVVLPSTSSELTRSNSSENKIPNEDISVSTSSRYLVFDKILALMKKSPGRRGDKTSPARRLDRSDAVRRNIDYDAGEDSSSLLITRSLDFPNRTSFRVDGVDDGEIDRIYQYIGVSGPEDFAISSDAWKARMEHERSSSDVVNKLKSLDLDSREAGPSGGVVASSSMNHKFQGHDLSEAGSIGVVVASNFTLSESNKIENLNSLRDKEIVDGDMVENRCGIERKPTILVKSRGYLVHNDDVGVGGGIKGVRPPVLNVPRADKEVVDGGTVESKSGIEWKPTILVKSKGYLVSNDGGIKGVTSPVLNLRPTDKEVVDSGTVENRRGIKGVRPSVLKPPPVMKLPPVDLPGSSWDILTHFAPDSEIVRRPSSSSSSENGCDEEEAEDDKVEKEETGDMFIQLEDTTDEACSFTTNEGDSSSTVSNTSPICVSGGSINTSWQKGQLLRQGSFGSVYEAISEDGDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNILRYRGTDKDGSNLYIFLELVTQGSLLELYRRYQIRDSLISLYTKQILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETLFWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDLEPVEALFRIRRGTLPEVPDTLSLDARHFILKCLKLNPEERPTATELLNHPFVRRPLPSSGSGSTSPLIRR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [500-758]
- IPR050538: Mitogen-activated protein kinase kinase kinase (family) [88-767]
- IPR000719: Protein kinase domain (domain) [501-755]
Interaction partners: - Mitogen-activated protein kinase 4
- Disease resistance protein SUMM2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:0099402 (plant organ development), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0009611 (response to wounding), GO:1901698 (response to nitrogen compound), GO:0009888 (tissue development), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0006970 (response to osmotic stress), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0048364 (root development), GO:0048507 (meristem development), GO:0043412 (macromolecule modification), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound), GO:0000165 (MAPK cascade), GO:0009651 (response to salt stress), GO:0006796 (phosphate-containing compound metabolic process), GO:1902065 (response to L-glutamate), GO:0009631 (cold acclimation), GO:0022622 (root system development), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)