Protein: E3 ubiquitin-protein ligase TRIM45 (Q9H8W5)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response. Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response. May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway
Subcellular location: Cytoplasm. Nucleus
Sequence: MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGHPHWSCCGKFNEKSECTWTGGQSAPRSLLRTVAL
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [29-98]
- IPR000315: B-box-type zinc finger (domain) [130-227]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [44-53]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [397-497]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [395-499]
- IPR047153: TRIM45/56/19-like (family) [28-554]
- IPR017868: Filamin/ABP280 repeat-like (repeat) [394-497]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [29-54]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [24-105]
- IPR003649: B-box, C-terminal (domain) [234-360]
- IPR001298: Filamin/ABP280 repeat (repeat) [398-500]
Interaction partners: - SH3 and cysteine-rich domain-containing protein
- Sorbin and SH3 domain-containing protein 1
- F-BAR and double SH3 domains protein 2
- Spartin
- Killer cell immunoglobulin-like receptor 2DL1
- T-cell receptor-associated transmembrane adapter 1
- Killer cell immunoglobulin-like receptor 2DL4
- E3 ubiquitin-protein ligase TRIM41
- Killer cell immunoglobulin-like receptor 3DL1
- Killer cell immunoglobulin-like receptor 3DL3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0001704 (formation of primary germ layer), GO:1901564 (organonitrogen compound metabolic process), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0043412 (macromolecule modification), GO:0048568 (embryonic organ development), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0007369 (gastrulation), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0032446 (protein modification by small protein conjugation), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0016567 (protein ubiquitination), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0051865 (protein autoubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045171 (intercellular bridge), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)