Protein: SH3 and PX domain-containing protein 2B isoform X1 (A0A0R4IMX7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, podosome. Cytoplasm
Sequence: MPRRTVLEVTVQDVQKRRNPNKHYVYIIKVAWSDGSTEVIFRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKILFRRSHIRDVAMKRLKPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPSGKKKSGIVERASSFLKRGGDSSSADPLLLDQYVAVTDYEKQESSEISLYVGQVVEVIEKNESGWWFVSTEDAQGWVPATCLEAQDDPDDFSLPAEEEEKYTAIYPYSARDQDEIDLERGMTVEVIQKNLEGWWKIRYQGKEGWAPASYLKKADILSQKMAAGAPVHASTNDLDVACKQQNANKENKENQRDRFSPFSDSKRKVGARQRPPPRRDLTIPRGVNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGLKVEVIEKNSSGWWYIQIEDKEGWAPVTFIDKYKKTSSASRPNFLAPLPGEMEQLKLEDTSSNSTNSEHTWSKPLPDEPSSNSDLSTRSKLREWKPNAAKSSSHFSGPLPPPPSSPTAEEKPALPPRRESINKSLELEDKPKAELSKPLPPKPPVPGVIAPLVTPKAAPLKPDKPPEMKKDDKNKQLFLRNEMGLECGHNISVKEVKKFNLKHVAKQPPTKPKPDLQEDKPESPNPAPFLKPKPVIRPKPAPAAKPEPVAKNELDITNLRSKLRPSKPPELNSSDANQQNDTSSSSPPNNSRTNEEPKCLPKQQNGHGPSETTKPPKEPPQRPSVAPRRPPPPKKSSEPASPTDTRAPQKDLPEAKPAPPPQSRPPPPKTKAFPLPAPKDKEKEEPKPKVPVPPKPLVKPDKPGPPRDKLPPLIKEPSKEELFLAVADFEGDEQTPGFKEGAVFEVMERNTSGWWFCKNVSDGPVMEGWIPSNYLTKKP
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [163-878]
- IPR051228: NADPH Oxidase and PX Domain-Containing (family) [2-651]
- IPR036871: PX domain superfamily (homologous_superfamily) [2-138]
- IPR001452: SH3 domain (domain) [163-880]
- IPR035479: SH3PXD2B, SH3 domain 3 (domain) [371-423]
- IPR001683: Phox homology (domain) [4-128]
- IPR035480: SH3PXD2B, SH3 domain 4 (domain) [823-878]
- IPR037961: SH3PXD2, PX domain (domain) [6-124]
- IPR035477: SH3PXD2B, SH3 domain 1 (domain) [166-220]
- IPR001655: Neutrophil cytosol factor 1 (family) [110-213]
- IPR035478: SH3PXD2B, SH3 domain 2 (domain) [234-287]
Interaction partners: - PX domain-containing protein kinase-like protein
- SR-related CTD-associated factor 1
- Sorting nexin family member 21
- Hyaluronan mediated motility receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0005543 (phospholipid binding), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0035091 (phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0048870 (cell motility), GO:0009790 (embryo development), GO:0072593 (reactive oxygen species metabolic process), GO:0048513 (animal organ development), GO:0016477 (cell migration), GO:0048568 (embryonic organ development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0002102 (podosome), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)