Protein: Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14] (G5EBM1)
Organism: Caenorhabditis elegans
Function: Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels.
Sequence: MVLKTIEDNCKSQFDDDLVEDFNNFQTTSSMSSSTTISTEDFNTIEIESTFEICRSGSYTEEPILGENDEFLIDFEMERFLKFLKDKTKQVEKRKEPFSQKEIYAVFQRRIKSELCIETVKKKFQPLLPNAIQTCEFDEETMIRMIYGAGIRIDSVDFWNRFTSKATISLDCYSRLISYSSDSLTLSGTHRSGFTYHWISTPPVTYHRTENKDPNIQEPSPVEFLDVQSSLGSSMKPPILDKPTKLDDPAETRHDCSYSLEEYDSQSRMPRTDAKKSNHKHKYCYEMNSNPRGTVLILSNENFKNMERRVGTKQDEVNLTKLFQKLQYTVICKRNLEAESMLEAIKEFAEMAHTDSIILFLLSHGDGAGSVFGIDDMPVNVMEVSTYLAYHQNLLLKPKWVAVSACRGGKLNMGVPVDGLPALEDKCAPISKFWNLMMSRIMPGTFTSLNADVIISFSTTDGFTSYRDEEAGTWYIKSMCKVFNKHSKTMHLLDILTETGRNVVTKYENVQGNVVLKQAPEILSRLTKQWHFSRSM
InterPro domains: - IPR011600: Peptidase C14, caspase domain (domain) [292-529]
- IPR006570: SPK domain (domain) [76-188]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [284-534]
- IPR016129: Peptidase family C14A, His active site (active_site) [353-365]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [450-534]
- IPR052039: Caspase-related proteases and regulators (family) [210-532]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [278-533]
- IPR001309: Peptidase C14, p20 domain (domain) [291-410]
Interaction partners: - RING-type domain-containing protein
- Cell death protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051321 (meiotic cell cycle), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:1903046 (meiotic cell cycle process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0050790 (regulation of catalytic activity), GO:0007281 (germ cell development), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0045132 (meiotic chromosome segregation), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0010453 (regulation of cell fate commitment), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:0140013 (meiotic nuclear division), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0045786 (negative regulation of cell cycle), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0002164 (larval development), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0043086 (negative regulation of catalytic activity), GO:0098813 (nuclear chromosome segregation), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0051336 (regulation of hydrolase activity), GO:0048477 (oogenesis), GO:1901214 (regulation of neuron death), GO:0010939 (regulation of necrotic cell death), GO:0036211 (protein modification process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0007292 (female gamete generation), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0009792 (embryo development ending in birth or egg hatching), GO:0042981 (regulation of apoptotic process), GO:0000018 (regulation of DNA recombination), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0043066 (negative regulation of apoptotic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043523 (regulation of neuron apoptotic process), GO:0051276 (chromosome organization), GO:1903318 (negative regulation of protein maturation), GO:0045862 (positive regulation of proteolysis), GO:0032984 (protein-containing complex disassembly), GO:0051345 (positive regulation of hydrolase activity), GO:1903317 (regulation of protein maturation), GO:1903319 (positive regulation of protein maturation), GO:0044093 (positive regulation of molecular function), GO:0010952 (positive regulation of peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:0051261 (protein depolymerization), GO:0010954 (positive regulation of protein processing), GO:0070613 (regulation of protein processing), GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0032446 (protein modification by small protein conjugation), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0010950 (positive regulation of endopeptidase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0016567 (protein ubiquitination), GO:2001056 (positive regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)