Protein: MARCKS-related protein 1-A (MARCKS-like protein 1-A) (MARCKS-like protein 1-B) (Q6PD99)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49006}. Cell membrane {ECO:0000250|UniProtKB:P49006}; Lipid-anchor {ECO:0000250|UniProtKB:P49006}. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. {ECO:0000250|UniProtKB:P49006}.
Sequence: MGAQLTKGEATVEGKAVADKANGQENGHVKTNGDVSTKPDGEAVAADGNGTAEVAKDEAPKTEEGDGIEAAPATEAEASKSDGEAAKETKKKKKFSLKNSFKFKGISLKKNKKASEEAAEAVATPTTAEDKPEENGQAATETKEEEPAAETNETPAPEAEAEPKVEEAEPKAEEPAQQTETAPTEETTKSEESPAPVEETTPTESSDPEPAAE
InterPro domains: - IPR002101: Myristoylated alanine-rich C-kinase substrate MARCKS (family) [1-209]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0032879 (regulation of localization), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051050 (positive regulation of transport), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0048729 (tissue morphogenesis), GO:0051047 (positive regulation of secretion), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0060341 (regulation of cellular localization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003407 (neural retina development), GO:0060041 (retina development in camera-type eye), GO:0000902 (cell morphogenesis), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0010842 (retina layer formation), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0010647 (positive regulation of cell communication), GO:0009790 (embryo development), GO:0051222 (positive regulation of protein transport), GO:1903532 (positive regulation of secretion by cell), GO:0051216 (cartilage development), GO:1904951 (positive regulation of establishment of protein localization), GO:0048880 (sensory system development), GO:0070201 (regulation of establishment of protein localization), GO:0061448 (connective tissue development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0032880 (regulation of protein localization), GO:0050714 (positive regulation of protein secretion), GO:0035914 (skeletal muscle cell differentiation), GO:0030855 (epithelial cell differentiation), GO:0007420 (brain development), GO:0051223 (regulation of protein transport), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0002064 (epithelial cell development), GO:0001501 (skeletal system development), GO:0060537 (muscle tissue development), GO:0060541 (respiratory system development), GO:0007417 (central nervous system development), GO:0051046 (regulation of secretion), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0050708 (regulation of protein secretion), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0003381 (epithelial cell morphogenesis involved in gastrulation), GO:0060538 (skeletal muscle organ development), GO:0003382 (epithelial cell morphogenesis), GO:0150063 (visual system development), GO:0007519 (skeletal muscle tissue development), GO:0060026 (convergent extension), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005884 (actin filament), GO:0015629 (actin cytoskeleton)