Protein: Protein DETOXIFICATION 41 (Q9LYT3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as a flavonoid/H(+)-antiporter that control the vacuolar sequestration of flavonoids in the seed coat endothelium. Could transport the anthocyanin cyanidin-3-O-glucoside and epicatechin 3'-O-glucoside in vitro
Subcellular location: Vacuole membrane; Multi-pass membrane protein. Note=Tonoplast
Sequence: MSSTETYEPLLTRLHSDSQITERSSPEIEEFLRRRGSTVTPRWWLKLAVWESKLLWTLSGASIVVSVLNYMLSFVTVMFTGHLGSLQLAGASIATVGIQGLAYGIMLGMASAVQTVCGQAYGARQYSSMGIICQRAMVLHLAAAVFLTFLYWYSGPILKTMGQSVAIAHEGQIFARGMIPQIYAFALACPMQRFLQAQNIVNPLAYMSLGVFLLHTLLTWLVTNVLDFGLLGAALILSFSWWLLVAVNGMYILMSPNCKETWTGFSTRAFRGIWPYFKLTVASAVMLCLEIWYNQGLVIISGLLSNPTISLDAISICMYYLNWDMQFMLGLSAAISVRVSNELGAGNPRVAMLSVVVVNITTVLISSVLCVIVLVFRVGLSKAFTSDAEVIAAVSDLFPLLAVSIFLNGIQPILSGVAIGSGWQAVVAYVNLVTYYVIGLPIGCVLGFKTSLGVAGIWWGMIAGVILQTLTLIVLTLKTNWTSEVENAAQRVKTSATENQEMANAGV
InterPro domains: - IPR002528: Multi antimicrobial extrusion protein (family) [62-458]
- IPR045069: Multidrug and toxic compound extrusion family, eukaryotic (family) [51-487]
Interaction partners: - ATPase 10, plasma membrane-type
- Glutathione S-transferase F12
- Transcription factor TT2
- Transcription factor TT8
- Anthocyanidin reductase
- Protein TRANSPARENT TESTA 1
- Leucoanthocyanidin dioxygenase
- Dihydroflavonol 4-reductase
- Protein TRANSPARENT TESTA 16
- Protein TRANSPARENT TESTA GLABRA 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016787 (hydrolase activity), GO:0015562 (efflux transmembrane transporter activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016812 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0010162 (seed dormancy process), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0022611 (dormancy process), GO:0044237 (cellular metabolic process), GO:0009791 (post-embryonic development), GO:0021700 (developmental maturation), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0044550 (secondary metabolite biosynthetic process), GO:0048316 (seed development), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0009698 (phenylpropanoid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0048608 (reproductive structure development), GO:0010431 (seed maturation), GO:0006725 (cellular aromatic compound metabolic process), GO:0071695 (anatomical structure maturation), GO:0061458 (reproductive system development), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0010154 (fruit development), GO:0009699 (phenylpropanoid biosynthetic process), GO:0018958 (phenol-containing compound metabolic process), GO:0046189 (phenol-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0009705 (plant-type vacuole membrane)