Protein: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (G4XH65)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR002527}.
Sequence: MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
InterPro domains: - IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [303-555]
- IPR024736: Oestrogen-type nuclear receptor final C-terminal domain (domain) [552-595]
- IPR024178: Estrogen receptor/oestrogen-related receptor (family) [37-583]
- IPR001292: Estrogen receptor (family) [1-595]
- IPR046944: Estrogen receptor, N-terminal (domain) [42-181]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [311-547]
- IPR050200: Nuclear hormone receptor family NR3 subfamily (family) [87-546]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [182-257]
- IPR001723: Nuclear hormone receptor (family) [246-523]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [175-279]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003682 (chromatin binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003707 (nuclear steroid receptor activity), GO:0004879 (nuclear receptor activity), GO:0042802 (identical protein binding), GO:0008013 (beta-catenin binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0098531 (ligand-activated transcription factor activity), GO:0001098 (basal transcription machinery binding), GO:0019899 (enzyme binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0019900 (kinase binding), GO:0140296 (general transcription initiation factor binding), GO:0051117 (ATPase binding), GO:0140297 (DNA-binding transcription factor binding), GO:0003677 (DNA binding), GO:0001099 (basal RNA polymerase II transcription machinery binding), GO:0001221 (transcription coregulator binding), GO:0043565 (sequence-specific DNA binding), GO:0001091 (RNA polymerase II general transcription initiation factor binding), GO:0001222 (transcription corepressor binding), GO:0000976 (transcription cis-regulatory region binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0017025 (TBP-class protein binding), GO:0001223 (transcription coactivator binding), GO:0019901 (protein kinase binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0016922 (nuclear receptor binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0030331 (nuclear estrogen receptor binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0019222 (regulation of metabolic process), GO:0033036 (macromolecule localization), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0009725 (response to hormone), GO:0044087 (regulation of cellular component biogenesis), GO:0009755 (hormone-mediated signaling pathway), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051128 (regulation of cellular component organization), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0030522 (intracellular receptor signaling pathway), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0051341 (regulation of oxidoreductase activity), GO:0043254 (regulation of protein-containing complex assembly), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0032355 (response to estradiol), GO:0048545 (response to steroid hormone), GO:0043627 (response to estrogen), GO:0010468 (regulation of gene expression), GO:0043401 (steroid hormone mediated signaling pathway), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:1904407 (positive regulation of nitric oxide metabolic process), GO:0071310 (cellular response to organic substance), GO:1902532 (negative regulation of intracellular signal transduction), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0030518 (intracellular steroid hormone receptor signaling pathway), GO:0032870 (cellular response to hormone stimulus), GO:0080164 (regulation of nitric oxide metabolic process), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0008104 (protein localization), GO:0051253 (negative regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0051353 (positive regulation of oxidoreductase activity), GO:0030520 (intracellular estrogen receptor signaling pathway), GO:2001141 (regulation of RNA biosynthetic process), GO:2000629 (negative regulation of miRNA metabolic process), GO:0045429 (positive regulation of nitric oxide biosynthetic process), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0045898 (regulation of RNA polymerase II transcription preinitiation complex assembly), GO:0033365 (protein localization to organelle), GO:0071392 (cellular response to estradiol stimulus), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0071383 (cellular response to steroid hormone stimulus), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0045428 (regulation of nitric oxide biosynthetic process), GO:2000628 (regulation of miRNA metabolic process), GO:0032768 (regulation of monooxygenase activity), GO:0034502 (protein localization to chromosome), GO:0045892 (negative regulation of DNA-templated transcription), GO:0032770 (positive regulation of monooxygenase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:1902893 (regulation of miRNA transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:2000142 (regulation of DNA-templated transcription initiation), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0050999 (regulation of nitric-oxide synthase activity), GO:1902894 (negative regulation of miRNA transcription), GO:2000144 (positive regulation of DNA-templated transcription initiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0051000 (positive regulation of nitric-oxide synthase activity), GO:0060260 (regulation of transcription initiation by RNA polymerase II), GO:0071168 (protein localization to chromatin), GO:0060261 (positive regulation of transcription initiation by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0016020 (membrane), GO:0000785 (chromatin), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005667 (transcription regulator complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0000791 (euchromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)