Protein: Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (P18519)
Organism: Gallus gallus (Chicken)
Function: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (By similarity). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (By similarity). Necessary for the circadian oscillation of clock genes in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9Z0W1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9Z0W1}. Perikaryon {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9Z0W1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z0W1}.
Sequence: MAGFVPLLLLLLPAGPTWGSKEKCLTKMYTTSGECCKACNLGEGVVQPCGVNQTVCEPCLDSVTYSDTVSATEPCKPCTQCVGLHSMSAPCVESDDAVCRCAYGYFQDELSGSCKECSICEVGFGLMFPCRDSQDTVCEECPEGTFSDEANFVDPCLPCTICEENEVMVKECTATSDAECRDLHPRWTTHTPSLAGSDSPEPITRDPFNTEGMATTLADIVTTVMGSSQPVVSRGTADNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANNRPVNQTPSPEGEKLHSDSGISVDSQSLHDQQPPNQSTQGPAPKGDGSLYASLPPSKQEEVEKLLSSSAEETWRQLAGELGYKEDLIDCFTREESPARALLADWSAKETATLDALLVALRKIQRGDIAESLYSESTATSPV
InterPro domains: - IPR034046: Tumor necrosis factor receptor 16, N-terminal (domain) [22-180]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [323-416]
- IPR001368: TNFR/NGFR cysteine-rich region (domain) [24-180]
- IPR041448: Tumor necrosis factor receptor member 16, transmembrane domain (domain) [235-272]
- IPR052302: Neurotrophin receptor-related death domain-containing protein (family) [8-416]
- IPR022325: Tumour necrosis factor receptor 16 (family) [42-157]
- IPR000488: Death domain (domain) [322-410]
Interaction partners: - Beta-nerve growth factor
- Neurotrophin-3
- Fibroblast growth factor
- Kit ligand
- TNF receptor-associated factor
- Disintegrin and metalloproteinase domain-containing protein 17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0012501 (programmed cell death), GO:0030968 (endoplasmic reticulum unfolded protein response), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0035966 (response to topologically incorrect protein), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0010033 (response to organic substance), GO:0034976 (response to endoplasmic reticulum stress), GO:0035967 (cellular response to topologically incorrect protein), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0071310 (cellular response to organic substance), GO:0006915 (apoptotic process), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0006986 (response to unfolded protein), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010976 (positive regulation of neuron projection development), GO:0034620 (cellular response to unfolded protein), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043233 (organelle lumen), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)