Protein: Major prion protein (X6RKS3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
Sequence: MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQ
InterPro domains: - IPR020949: Prion, copper binding octapeptide repeat region (repeat) [50-95]
- IPR000817: Prion protein (family) [7-217]
- IPR036924: Prion/Doppel beta-ribbon domain superfamily (homologous_superfamily) [90-217]
- IPR022416: Prion/Doppel protein, beta-ribbon domain (domain) [113-217]
- IPR025860: Major prion protein N-terminal (domain) [1-28]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0044877 (protein-containing complex binding), GO:0030674 (protein-macromolecule adaptor activity), GO:0043167 (ion binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0140693 (molecular condensate scaffold activity), GO:0005102 (signaling receptor binding), GO:0042277 (peptide binding), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0008092 (cytoskeletal protein binding), GO:0046872 (metal ion binding), GO:0035254 (glutamate receptor binding), GO:0001540 (amyloid-beta binding), GO:0001664 (G protein-coupled receptor binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0010942 (positive regulation of cell death), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0032409 (regulation of transporter activity), GO:0034762 (regulation of transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031647 (regulation of protein stability), GO:0010033 (response to organic substance), GO:0010035 (response to inorganic substance), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:1901216 (positive regulation of neuron death), GO:0010038 (response to metal ion), GO:0071417 (cellular response to organonitrogen compound), GO:1901652 (response to peptide), GO:0050890 (cognition), GO:0030030 (cell projection organization), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0051248 (negative regulation of protein metabolic process), GO:0043954 (cellular component maintenance), GO:1901699 (cellular response to nitrogen compound), GO:1901214 (regulation of neuron death), GO:0010468 (regulation of gene expression), GO:0019932 (second-messenger-mediated signaling), GO:0007613 (memory), GO:0010243 (response to organonitrogen compound), GO:0071241 (cellular response to inorganic substance), GO:0051247 (positive regulation of protein metabolic process), GO:0022898 (regulation of transmembrane transporter activity), GO:0051338 (regulation of transferase activity), GO:0099173 (postsynapse organization), GO:0043269 (regulation of monoatomic ion transport), GO:0043085 (positive regulation of catalytic activity), GO:0031648 (protein destabilization), GO:0034330 (cell junction organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0051347 (positive regulation of transferase activity), GO:0030162 (regulation of proteolysis), GO:0044070 (regulation of monoatomic anion transport), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0120036 (plasma membrane bounded cell projection organization), GO:0043523 (regulation of neuron apoptotic process), GO:0019722 (calcium-mediated signaling), GO:0019220 (regulation of phosphate metabolic process), GO:1903318 (negative regulation of protein maturation), GO:0071248 (cellular response to metal ion), GO:0043549 (regulation of kinase activity), GO:1901653 (cellular response to peptide), GO:1904645 (response to amyloid-beta), GO:0097061 (dendritic spine organization), GO:0046688 (response to copper ion), GO:0007616 (long-term memory), GO:0050808 (synapse organization), GO:1903959 (regulation of monoatomic anion transmembrane transport), GO:0045861 (negative regulation of proteolysis), GO:1903317 (regulation of protein maturation), GO:0031401 (positive regulation of protein modification process), GO:0043525 (positive regulation of neuron apoptotic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:1904646 (cellular response to amyloid-beta), GO:0033674 (positive regulation of kinase activity), GO:0010359 (regulation of anion channel activity), GO:0010955 (negative regulation of protein processing), GO:0045859 (regulation of protein kinase activity), GO:0070613 (regulation of protein processing), GO:0071280 (cellular response to copper ion), GO:0106027 (neuron projection organization), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0035584 (calcium-mediated signaling using intracellular calcium source), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0061097 (regulation of protein tyrosine kinase activity), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0045860 (positive regulation of protein kinase activity), GO:0061098 (positive regulation of protein tyrosine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)