Protein: P2X purinoceptor 6 (P2X6) (ATP receptor) (P2XM) (Purinergic receptor) (Purinergic receptor P2X-like 1) (P51579)
Organism: Rattus norvegicus (Rat)
Function: Receptor for ATP that acts as a ligand-gated ion channel.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15044628, ECO:0000269|PubMed:16452399}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:12077178, ECO:0000269|PubMed:16452399}. Nucleus {ECO:0000250|UniProtKB:O54803}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54803}; Multi-pass membrane protein {ECO:0000255}. Note=Monomers remain anchored to the endoplasmic reticulum (ER) membrane by the hydrophobic N-terminal end (PubMed:12077178, PubMed:15044628, PubMed:16452399). Heteromerization of P2RX6 subunits with either P2RX2 or P2RX4 subunits guides the P2RX6 subunit to the plasma membrane (PubMed:16452399). Retention of P2RX6 subunit in the ER allows it to reach the nucleus (PubMed:16452399). In neurons, mainly expressed in the cell body of the hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000269|PubMed:12077178, ECO:0000269|PubMed:15044628, ECO:0000269|PubMed:16452399}.
Sequence: MQLQPAGTGSMASAVAAALVSWGFLDYKTEKYVMTRNCWVGISQRLLQLGVVVYVIGWALLAKKGYQEWDMDPQISVITKLKGVSVTQVKELEKRLWDVADFVRPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGEMGTYSHGIKTGQCVAFNGTHRTCEIWSWCPVESSAVPRKPLLAQAKNFTLFIKNTVTFNKFNFSRTNALDTWDNTYFKYCLYDSLSSPYCPVFRIGDLVAMTGGDFEDLALLGGAVGINIHWDCNLDTKGSDCSPQYSFQLQERGYNFRTANYWWAASGVESRSLLKLYGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKATTNSA
InterPro domains: - IPR001429: P2X purinoreceptor (family) [11-389]
- IPR027309: P2X purinoreceptor extracellular domain superfamily (homologous_superfamily) [70-346]
- IPR053792: ATP P2X receptor, conserved site (conserved_site) [263-289]
- IPR003049: P2X6 purinoceptor (family) [21-388]
Interaction partners: - P2X purinoceptor 2
- P2X purinoceptor 4
- P2X purinoceptor 1
- P2X purinoceptor 3
- P2X purinoceptor 5
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2D
- Glutamate receptor ionotropic, NMDA 2A
- P2Y purinoceptor 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0035381 (ATP-gated ion channel activity), GO:0004931 (extracellularly ATP-gated monoatomic cation channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0023056 (positive regulation of signaling), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0033555 (multicellular organismal response to stress), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0040012 (regulation of locomotion), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0051049 (regulation of transport), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0009611 (response to wounding), GO:0050920 (regulation of chemotaxis), GO:0098660 (inorganic ion transmembrane transport), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0032101 (regulation of response to external stimulus), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0048266 (behavioral response to pain), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:0010035 (response to inorganic substance), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0019226 (transmission of nerve impulse), GO:0006810 (transport), GO:0048265 (response to pain), GO:0042391 (regulation of membrane potential), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0002931 (response to ischemia), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0071417 (cellular response to organonitrogen compound), GO:0046683 (response to organophosphorus), GO:1905523 (positive regulation of macrophage migration), GO:1905521 (regulation of macrophage migration), GO:0071310 (cellular response to organic substance), GO:1902075 (cellular response to salt), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:0030334 (regulation of cell migration), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:0001508 (action potential), GO:0048678 (response to axon injury), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0071241 (cellular response to inorganic substance), GO:0019228 (neuronal action potential), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0033198 (response to ATP), GO:1901701 (cellular response to oxygen-containing compound), GO:1902531 (regulation of intracellular signal transduction), GO:0006812 (monoatomic cation transport), GO:0051897 (positive regulation of protein kinase B signaling), GO:0010959 (regulation of metal ion transport), GO:0071407 (cellular response to organic cyclic compound), GO:0070588 (calcium ion transmembrane transport), GO:0071248 (cellular response to metal ion), GO:1903975 (regulation of glial cell migration), GO:0051896 (regulation of protein kinase B signaling), GO:0010043 (response to zinc ion), GO:0019233 (sensory perception of pain), GO:1903977 (positive regulation of glial cell migration), GO:0006816 (calcium ion transport), GO:0014074 (response to purine-containing compound), GO:0050954 (sensory perception of mechanical stimulus), GO:0071318 (cellular response to ATP), GO:0050975 (sensory perception of touch), GO:0071294 (cellular response to zinc ion), GO:0030001 (metal ion transport), GO:0002028 (regulation of sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0043025 (neuronal cell body), GO:0043197 (dendritic spine), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0043195 (terminal bouton), GO:0099572 (postsynaptic specialization), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0032279 (asymmetric synapse), GO:0030424 (axon), GO:0044309 (neuron spine)