Protein: Sialate:O-sulfotransferase 2 (D4PHA7)
Organism: Mus musculus (Mouse)
Function: Sialate:O-sulfotransferase that catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycoproteins such as TF/transferrin
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence: MAKLWFKFQRCFRYFRRKPVRFFTLLAIYLTAGSLVFLHSGFVGQPAVPQSQASPAAGSPVEGAELPFLGDLHLGRGFRDTVEASSIARRYGPTFKGKDTSERAKLGDYGGAWSRALKGRVVREKEKEKEEEKAKYIGCYLDDTQSRALRGVSFFDYKKMTVFRCQDNCAERGYLYAGLEFGAECYCGHKIQAANVSESDCDMECKGERGSVCGGINRLSVYRLQLAQESARRYGSAVFRGCFRRPNNLSLALPVSAAMPNMSVDKCVDLCTEKEFPLAALAGTACHCGFPTTRFPLHDREDEQLCAQKCSAEEFESCGTPSYFIVYQTQVQDNRCMDRRFLPAKSKKLIALASFPGAGNTWARHLIELATGFYTGSYYFDGSLYNKGFKGERDHWRSGRTICIKTHESGQKEIEAFDAAILLIRNPYKALMAEFNRKYGGHIGFAAHAHWKGKEWPEFVRNYAPWWATHTLDWLKFGKTVLVVHFEDLKQDLFTQLGRMVSLLGVAVREDRLLCVESQKDGNFKRSGLRKLEYDPYTAEMRRTIAAYIRMVDTALRSRNLTGVPDAYGPR
InterPro domains: - IPR051589: Sialate:O-sulfotransferase (family) [13-568]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [318-550]
- IPR002889: Carbohydrate-binding WSC (domain) [133-330]
Interaction partners: - Fanconi anemia group M protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0008146 (sulfotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0002252 (immune effector process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:0016486 (peptide hormone processing), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0019538 (protein metabolic process), GO:0050886 (endocrine process), GO:0044249 (cellular biosynthetic process), GO:0002443 (leukocyte mediated immunity), GO:0008217 (regulation of blood pressure), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0003013 (circulatory system process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0008015 (blood circulation), GO:0003073 (regulation of systemic arterial blood pressure), GO:0002444 (myeloid leukocyte mediated immunity), GO:0003073 (regulation of systemic arterial blood pressure), GO:0002444 (myeloid leukocyte mediated immunity), GO:0003071 (renal system process involved in regulation of systemic arterial blood pressure), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0001990 (regulation of systemic arterial blood pressure by hormone), GO:0010467 (gene expression), GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin), GO:0006029 (proteoglycan metabolic process), GO:0002448 (mast cell mediated immunity), GO:0019233 (sensory perception of pain), GO:0003044 (regulation of systemic arterial blood pressure mediated by a chemical signal), GO:0009101 (glycoprotein biosynthetic process), GO:0003044 (regulation of systemic arterial blood pressure mediated by a chemical signal), GO:0030166 (proteoglycan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)