Protein: Prohibitin (C9JW96)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU366048}.
Sequence: MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAED
InterPro domains: - IPR001107: Band 7 domain (domain) [26-206]
- IPR000163: Prohibitin (family) [12-245]
- IPR036013: Band 7/SPFH domain superfamily (homologous_superfamily) [55-194]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0005515 (protein binding), GO:0003712 (transcription coregulator activity), GO:0003714 (transcription corepressor activity), GO:0005102 (signaling receptor binding), GO:0001846 (opsonin binding), GO:0046983 (protein dimerization activity), GO:0001848 (complement binding), GO:0019899 (enzyme binding), GO:0046982 (protein heterodimerization activity), GO:0042826 (histone deacetylase binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0001503 (ossification), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0032103 (positive regulation of response to external stimulus), GO:0002250 (adaptive immune response), GO:0043207 (response to external biotic stimulus), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:0009725 (response to hormone), GO:0002218 (activation of innate immune response), GO:0009894 (regulation of catabolic process), GO:0009755 (hormone-mediated signaling pathway), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0030308 (negative regulation of cell growth), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0009615 (response to virus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001649 (osteoblast differentiation), GO:0008285 (negative regulation of cell population proliferation), GO:0001558 (regulation of cell growth), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0030522 (intracellular receptor signaling pathway), GO:0031647 (regulation of protein stability), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0002757 (immune response-activating signaling pathway), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0009895 (negative regulation of catabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0002699 (positive regulation of immune effector process), GO:0033143 (regulation of intracellular steroid hormone receptor signaling pathway), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0033144 (negative regulation of intracellular steroid hormone receptor signaling pathway), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0048545 (response to steroid hormone), GO:0010468 (regulation of gene expression), GO:0043401 (steroid hormone mediated signaling pathway), GO:0043412 (macromolecule modification), GO:0140374 (antiviral innate immune response), GO:0002753 (cytosolic pattern recognition receptor signaling pathway), GO:0032740 (positive regulation of interleukin-17 production), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0002920 (regulation of humoral immune response), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0034097 (response to cytokine), GO:0042177 (negative regulation of protein catabolic process), GO:0030449 (regulation of complement activation), GO:0045088 (regulation of innate immune response), GO:0042176 (regulation of protein catabolic process), GO:0051607 (defense response to virus), GO:0071310 (cellular response to organic substance), GO:0002922 (positive regulation of humoral immune response), GO:0051248 (negative regulation of protein metabolic process), GO:0045745 (positive regulation of G protein-coupled receptor signaling pathway), GO:0010628 (positive regulation of gene expression), GO:1902532 (negative regulation of intracellular signal transduction), GO:0032660 (regulation of interleukin-17 production), GO:0036211 (protein modification process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0030518 (intracellular steroid hormone receptor signaling pathway), GO:0032870 (cellular response to hormone stimulus), GO:0140546 (defense response to symbiont), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0050821 (protein stabilization), GO:0034341 (response to type II interferon), GO:0014070 (response to organic cyclic compound), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0007005 (mitochondrion organization), GO:0042981 (regulation of apoptotic process), GO:0002221 (pattern recognition receptor signaling pathway), GO:0098732 (macromolecule deacylation), GO:2001141 (regulation of RNA biosynthetic process), GO:0071345 (cellular response to cytokine stimulus), GO:0035601 (protein deacylation), GO:0043410 (positive regulation of MAPK cascade), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0060765 (regulation of androgen receptor signaling pathway), GO:0043409 (negative regulation of MAPK cascade), GO:0043408 (regulation of MAPK cascade), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0070741 (response to interleukin-6), GO:0071383 (cellular response to steroid hormone stimulus), GO:0016570 (histone modification), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0006476 (protein deacetylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0071354 (cellular response to interleukin-6), GO:0016575 (histone deacetylation), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)