Protein: Negative regulator of sporulation MDS3 (Q5ADT1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Negatively regulates early sporulation-specific genes (By similarity). TOR signaling pathway component that contributes to morphogenesis as a regulator of this key morphogenetic pathway. Required for growth and hyphal formation at pH 9, for full virulence in a mouse model of systemic infection and for biofilm formation. Involved in chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens
Subcellular location: Cytoplasm
Sequence: MSTLIPTASACYSLQLPPTEKDDRLNLNVRTGSASTLYNSLIFVHGGLTIGLELLNYTIPELNEIFYNRINISASKYKTVEKYLSGELFYLSLIERNWSRVVLEELEIRPKPRLLHQICAFNNCLYLFGGLALSQENDEDPTLVPCNDLWEFDLVLKKWTLLDDGSNYELDDAVPSPRFNHKLTVISSLSFANRKDHFGLFIAGGKDKQSNEIYDNSIFDLVEKRYVGSQPFRLVATTGDDTKDKETGLNEFVSNPEHFLNVDQTRNAILSITDDADTPNRKQNKNPSNHHESIVVYGPTRQTGDCQNSLVSFKVGKREIKGGKVLRLHKNSRVAKLKQSIIPYNLRYPTAGLFGQNVVLTGFLPDEYEISIFVYNRPTGKWSRLNIFCSHEYGSHRFWGGFAWQSHHKVILIGNSMTSRTTSSVRFFSIMLTVSLPITNILVSSELSKGRSNNRTSSFVSHGEQRHHRNKSQNDSLLKAELSLESTTEDSTDSSSDKTAESVLDAPVPLANSRRQSFSSLGSDKSPTAVSFSDYVHYAAPKTTYTTIRSVFPPEAITLGRNAFNRIGDLIADIELVSCNGDRIPVSSAVLMERWGQHFISLLAKGYINAVDKFETDQALGLDENQRLRSKSSNSESSSSDIPKLKLSLSESLLSSSSGEHDKKEKMGLSSAHKPQKDVPQFRLPFQDSSESVNREEGSDCSKDRKTGGSSVSTAIDPHHVMPRKNSTSSFQSNSSSLLTSHLQDIPPQLPLPDEQIPAVPAAPVSYRSASRKNSQDHSSPRSSLIHTLTVLRNIPVSKSPRESPFSSPRPSMSGPSGGSADLFSSPFPSLKANYGKPPSNLRKKSYDMNDGTIESSLDSFSSGKSSMAKVSSVPGENPDSDESSIGFQEFNKNPISMFDNALLNFDNIDSENFRMEPSLIPRKLYIPFMTLTVKAFCEYLYTGQIGNKWLLAPTLMDNLLISKFYRVPLLYDLISEILFGVIGKKEAYIIGEARKLKARYFKLLRGANIPIDSNYEFPMDEYDGFLDTVDDGYLDITLLKKASKIHADSVAMSLKKKSVTSNNSRNASIRKEGSTTAESVLEEGEKQEEIVSKDDEDESRTGSTSEEDEVDKEYGLVYLEAKDKSLPTIGPRSKSIFDRQGLAAIEKLEEEQNDHQVHSIVEGEDHENLITLDELVASDAPSDYAIDLIFETATLVTDMKMLLRTSNLKAMTAKFRKCKADIEKEMADIEYQLTQMPSGSRNLAMKSANQLKESQLQSKSSPIIPTVSTVTPSPLPSISGVPSPRLPQQQLPEAQLPKLTKSTSSLSRIASHTSFKALRSMTDVTPMEKSTSDKSFRGKLQQTMLSRTPTNRNEDQDSSSASSIKSSSKKRGIFGLLTGLKR
InterPro domains: - IPR015915: Kelch-type beta-propeller (homologous_superfamily) [4-242]
Interaction partners: - ATP-dependent RNA helicase SUV3, mitochondrial
- Nuclear pore complex protein Nup85
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)