Protein: DNA mismatch repair protein MSH5 (AtMSH5) (MutS protein homolog 5) (F4JEP5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in meiotic recombination in association with MSH4. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation.
Subcellular location: Nucleus {ECO:0000269|PubMed:18318687}. Chromosome {ECO:0000269|PubMed:18318687}. Note=In pollen mother cells during meiosis, localizes to unsynapsed axes during leptotene and zygotene, but is not present on synapsed regions of zygotene nuclei. {ECO:0000269|PubMed:18318687}.
Sequence: MEEMEDTETEPQVYMACIQHGRRVGVSYYDCSVRQLHVLEFWEEDCSDFTLINMVKYQAKPSIIYASTKSEESFVAALQQNDGTDETTMVKLVKSSTFSYEQAWHRLVYLRVTGMDDGLNIKERICYLSSMMDVGSEVQVRVSGGLLAILESERIVETLEQNESGSASIAIDSVMEVPLNKFLKLDAAAHEALQIFQTDKHPSHMGIGRAKEGFSVFGMMNKCATPMGRRLLRSWFMRPILDLEVLDRRLNAISFFISSVELMASLRETLKSVKDISHLLKKFNSPTSLCTSNDWTAFLKSISALLHVNKIFEVGVSESLREHMRRFNLDIIEKAGLCISTELDYVYELVIGVIDVTRSKERGYQTLVKEGFCAELDELRQIYEELPEFLQEVSAMELEHFPHLHKEKLPPCIVYIQQIGYLMCIFGEKLDETALNRLTEFEFAFSDMDGETQRFFYHTSKTRELDNLLGDIYHKILDMERAIIRDLLSHTLLFSAHLLKAVNFVAELDCILSLACVAHQNNYVRPVLTVESLLDIRNGRHVLQEMAVDTFIPNDTEINDNGRIHIITGPNYSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIFCAMGSKFMTAEQSTFMIDLHQVGMMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISHFATCAEPPRVVVCTHLTELLNESCLPVSEKIKFYTMSVLRPDTESANMEEIVFLYRLIPGQTLLSYGLHCALLAGVPEEVVKRAAIVLDAFESNNNVDKLSLDKISSQDQAFKDAVDKFAELDISKGDIHAFFQDIFTS
InterPro domains: - IPR000432: DNA mismatch repair protein MutS, C-terminal (domain) [562-759]
- IPR045076: DNA mismatch repair MutS (family) [19-767]
- IPR007696: DNA mismatch repair protein MutS, core (domain) [189-547]
- IPR036187: DNA mismatch repair protein MutS, core domain superfamily (homologous_superfamily) [186-522]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [523-794]
- IPR011184: DNA mismatch repair Msh2-type (family) [1-803]
Interaction partners: - DNA mismatch repair protein MLH1
- DNA mismatch repair protein PMS1
- DNA mismatch repair protein MLH3
- DNA mismatch repair protein MSH3
- DNA mismatch repair protein MSH6
- Exonuclease 1
- DNA mismatch repair protein MSH7
- DNA mismatch repair protein MSH1, mitochondrial
- DNA mismatch repair protein MSH4
- ATP-dependent DNA helicase homolog MER3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0009987 (cellular process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:1903046 (meiotic cell cycle process), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0045132 (meiotic chromosome segregation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051026 (chiasma assembly), GO:0007131 (reciprocal meiotic recombination), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0006139 (nucleobase-containing compound metabolic process), GO:0016043 (cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0098813 (nuclear chromosome segregation), GO:0007127 (meiosis I), GO:0022607 (cellular component assembly), GO:0045143 (homologous chromosome segregation), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0007129 (homologous chromosome pairing at meiosis), GO:0006996 (organelle organization), GO:0048285 (organelle fission), GO:0006310 (DNA recombination), GO:0051276 (chromosome organization), GO:0000280 (nuclear division), GO:0035825 (homologous recombination), GO:0140527 (reciprocal homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)