Protein: Transcription factor atoh7 (Atonal bHLH transcription factor 7) (Helix-loop-helix protein zATH-5) (zATH5) (Protein atonal homolog 5) (Protein atonal homolog 7) (Protein lakritz) (Q8AW52)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (By similarity). Involved in the differentiation of retinal ganglion cells, photoreceptor population and optic nerve development. Required for retinal circadian rhythm photoentrainment (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8N100}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5}.
Sequence: MKPRRPSCADSGSDSDSRDPEKFESAMRRRMAANARERKRMQGLNTAFDRLRKVVPQWGQDKKLSKYETLQMALSYIMALNRILSDAGRHVDPQKDWLNLQFDGLQTEGYFMHYDSPVESDCMLSSFSYHYESL
InterPro domains: - IPR050359: Basic helix-loop-helix transcription factors (family) [22-88]
- IPR032663: Transcription factor ATOH7, basic helix-loop-helix (domain) [22-90]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [24-90]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [28-86]
Interaction partners: - Visual system homeobox 2
- Visual system homeobox 1
- POU domain protein
- Transcription factor HES-5
- Paired box protein Pax-6
- Six3
- Insulin gene enhancer protein isl-1
- Forkhead box protein N4
- Growth-associated protein 43.
- Sine oculis homeobox homolog 3a.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0045165 (cell fate commitment), GO:0048840 (otolith development), GO:0001709 (cell fate determination), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048839 (inner ear development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048663 (neuron fate commitment), GO:0008544 (epidermis development), GO:0007423 (sensory organ development), GO:0048664 (neuron fate determination), GO:0060113 (inner ear receptor cell differentiation), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0030855 (epithelial cell differentiation), GO:0042490 (mechanoreceptor differentiation), GO:0035315 (hair cell differentiation), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0043583 (ear development), GO:0042491 (inner ear auditory receptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)