Protein: Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25) (Q9D6H2)
Organism: Mus musculus (Mouse)
Function: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19253336}.
Sequence: MRKVDLCSVTEGTEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVKIEKLVIQSYLVRTLRIEKTTSKEPLDFEQWVEKDLVHTEGQLQNEEIVARDGYATFLRFIIVSAFDHFASVHSISAEGLTVSSLP
InterPro domains: - IPR033558: Intraflagellar transport protein 25 (family) [1-140]
- IPR000421: Coagulation factor 5/8, C-terminal domain (domain) [18-90]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [13-136]
Interaction partners: - Intraflagellar transport protein 27 homolog
- Intraflagellar transport protein 22 homolog
- Intraflagellar transport protein 46 homolog
- Intraflagellar transport protein 52 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 20 homolog
- Intraflagellar transport protein 88 homolog
- TRAF3-interacting protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0008037 (cell recognition), GO:0019953 (sexual reproduction), GO:0009566 (fertilization), GO:0035036 (sperm-egg recognition), GO:0009988 (cell-cell recognition), GO:0007339 (binding of sperm to zona pellucida), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030990 (intraciliary transport particle), GO:0097225 (sperm midpiece), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0098797 (plasma membrane protein complex), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium), GO:0036126 (sperm flagellum)