Protein: PI-3 kinase (Phosphatidylinositol 3-kinase 92E, isoform A (EC 2.7.1.137, EC 2.7.1.153, EC 2.7.1.154)) (Phosphatidylinositol 3-kinase 92E, isoform B) (Phosphatidylinositol 3-kinase 92E, isoform C) (Phosphoinositide 3-kinase, Dp110) (SD05105p) (Uncharacterized protein Pi3K92E) (P91634)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNMMDNRALAYVAHQPKYETPPEEAEPPCMRFSVNLWKNEMLNWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKNNKQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [532-722]
- IPR035892: C2 domain superfamily (homologous_superfamily) [344-513]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [752-1078]
- IPR015433: Phosphatidylinositol 3-/4-kinase (family) [218-1083]
- IPR000341: Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain (domain) [200-307]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [136-305]
- IPR002420: C2 phosphatidylinositol 3-kinase-type domain (domain) [336-522]
- IPR003113: Phosphatidylinositol 3-kinase, adaptor-binding domain (domain) [41-132]
- IPR042236: Phosphoinositide 3-kinase, accessory (PIK) domain superfamily (homologous_superfamily) [515-722]
- IPR018936: Phosphatidylinositol 3-/4-kinase, conserved site (conserved_site) [820-941]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [872-1078]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [788-1085]
- IPR001263: Phosphoinositide 3-kinase, accessory (PIK) domain (domain) [544-731]
Interaction partners: - Pi3K21B, isoform B
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Insulin-like receptor
- non-specific serine/threonine protein kinase
- Insulin receptor substrate 1
- RAC serine/threonine-protein kinase
- Autophagy-related 14
- Ras-like protein 1
- Serine/threonine-protein kinase mTor
- Beclin-1-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0052742 (phosphatidylinositol kinase activity), GO:0035004 (phosphatidylinositol 3-kinase activity), GO:0016303 (1-phosphatidylinositol-3-kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0045927 (positive regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0019637 (organophosphate metabolic process), GO:0001558 (regulation of cell growth), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0050803 (regulation of synapse structure or activity), GO:0051128 (regulation of cellular component organization), GO:0048638 (regulation of developmental growth), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0050807 (regulation of synapse organization), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0006644 (phospholipid metabolic process), GO:1901888 (regulation of cell junction assembly), GO:0090407 (organophosphate biosynthetic process), GO:0008582 (regulation of synaptic assembly at neuromuscular junction), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0051963 (regulation of synapse assembly), GO:0008654 (phospholipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:1904396 (regulation of neuromuscular junction development), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0046488 (phosphatidylinositol metabolic process), GO:0046854 (phosphatidylinositol phosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0019898 (extrinsic component of membrane), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0005942 (phosphatidylinositol 3-kinase complex), GO:1990234 (transferase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups)