Protein: Alpha-glucuronidase A (EC 3.2.1.139) (Alpha-glucosiduronase A) (Q5AQZ4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.
Subcellular location: Secreted {ECO:0000250}.
Sequence: MRSFLLLTALLGVAAVAEDGLAAWLRYAPIPHAKSYHKNLPSVIVPLNATAGRPIDTAAYELVDGIKGIFGKRVTLKNETRDDPNLPAVTVGTVEAYAEAGGDVSSVPELIDDGYYLSVAGPSVLILGQNERGALYGTFQYLERLAQGKVSDTSFASNPSAPIRWVNQWDNLQDGGTHGSVERGYGGDSIFFWDGRVRDDLTRASQYARLLASIGLNAVIVNNVNANETILTQENMDGVARIADAFRPYGIQLGLSLNFASPQSLGGLDTFDPFDERVISWWGEITDELYERIPDMAGYLVKANSEGQPGPFTYNRTLADGANLFARALQPHGGIVLFRAFVYDHENLNETLDWKADRANAAVEFFDGLDPQFEDNVVIQIKNGPIDFQVREPVSPLFAHLSQTASAVELQVTQEYLGQQCHLVYLAPMWKEVLDFDLRVDGKDSVVSDIVSGRRFNNTLGGYAGVVNVGLNTTWLGSHLAMSNLYAYGRLAWDPSADSVELLQEWIKMTFSHDQEVVDVITKMSMESWPAYENYSGNLGIQTLTDILLGHYGPNPASQDGNPWGQWTRADADSIGMDRTVWNGTGNAGQYPEEVYQMYENIDTTPDNLLLWFHHVPYTQRLKSGKTVIQHFYDAHYRGSATAQTFVSLWKTIKGKIDKERYEHVLFRLVYQAGHALVWRDSITNFYYNKSGIPDEAGRVGNHPYRIEAEDMELDGYEPYLVSPFEAASGSHCIVTSNNSTEGRASTPLKVKNGKYDIAVNYFDQAIGNSTWRLFLDDDLVGEWKGDLEYILGRAPSPYIDGQTAARITFKHVHIKSRSTLSIVGIPDGMEPAPIDYVSILPEGVID
InterPro domains: - IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [162-734]
- IPR037054: Alpha-glucuronidase, C-terminal domain superfamily (homologous_superfamily) [498-735]
- IPR011100: Glycosyl hydrolase family 67, catalytic domain (domain) [149-475]
- IPR029018: Beta-hexosaminidase-like, domain 2 (homologous_superfamily) [18-162]
- IPR011099: Glycosyl hydrolase family 67, C-terminal (domain) [477-699]
- IPR011395: Alpha glucuronidase (family) [1-728]
- IPR005154: Alpha glucuronidase, N-terminal (domain) [23-141]
Interaction partners: - Xylanolytic transcriptional activator xlnR
- Endo-1,4-beta-xylanase B
- Exo-1,4-beta-xylosidase xlnD
- DNA-binding protein creA
- Endo-1,4-beta-xylanase C
- Endo-1,4-beta-xylanase A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0071554 (cell wall organization or biogenesis), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044036 (cell wall macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:0010383 (cell wall polysaccharide metabolic process), GO:0016998 (cell wall macromolecule catabolic process), GO:0016052 (carbohydrate catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0005976 (polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0044347 (cell wall polysaccharide catabolic process), GO:0010410 (hemicellulose metabolic process), GO:2000895 (hemicellulose catabolic process), GO:0045491 (xylan metabolic process), GO:0045493 (xylan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)