Protein: Regulator of G-protein signaling 2 (RGS2) (Q9JHX0)
Organism: Rattus norvegicus (Rat)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P41220}. Cytoplasm {ECO:0000250|UniProtKB:P41220}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P41220}.
Sequence: MQSAMFLAVQHDCVPMDKSAGNGPKVEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQTFIKPSPEEALLWAEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
InterPro domains: - IPR044926: RGS, subdomain 2 (homologous_superfamily) [105-184]
- IPR034947: Regulator of G-protein signalling 2, regulator of G protein signaling domain (domain) [84-197]
- IPR016137: RGS domain (domain) [80-199]
- IPR024066: RGS, subdomain 1/3 (homologous_superfamily) [78-198]
- IPR036305: RGS domain superfamily (homologous_superfamily) [72-200]
Interaction partners: - Guanine nucleotide-binding protein G
- Adenylate cyclase type 3
- cGMP-dependent protein kinase 2
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha
- Neurabin-2
- Guanine nucleotide-binding protein subunit beta-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0001965 (G-protein alpha-subunit binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0019900 (kinase binding), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0065009 (regulation of molecular function), GO:0045926 (negative regulation of growth), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0048731 (system development), GO:0046621 (negative regulation of organ growth), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0046620 (regulation of organ growth), GO:0043502 (regulation of muscle adaptation), GO:0032970 (regulation of actin filament-based process), GO:0034763 (negative regulation of transmembrane transport), GO:0002027 (regulation of heart rate), GO:0042391 (regulation of membrane potential), GO:0030308 (negative regulation of cell growth), GO:0045595 (regulation of cell differentiation), GO:0051128 (regulation of cellular component organization), GO:0014741 (negative regulation of muscle hypertrophy), GO:0048638 (regulation of developmental growth), GO:1902074 (response to salt), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0032891 (negative regulation of organic acid transport), GO:0001558 (regulation of cell growth), GO:0034762 (regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0051953 (negative regulation of amine transport), GO:0010033 (response to organic substance), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:1901698 (response to nitrogen compound), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:1903524 (positive regulation of blood circulation), GO:0043271 (negative regulation of monoatomic ion transport), GO:0010647 (positive regulation of cell communication), GO:0099177 (regulation of trans-synaptic signaling), GO:0097305 (response to alcohol), GO:0045823 (positive regulation of heart contraction), GO:0061548 (ganglion development), GO:0061117 (negative regulation of heart growth), GO:1903789 (regulation of amino acid transmembrane transport), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0098815 (modulation of excitatory postsynaptic potential), GO:0032956 (regulation of actin cytoskeleton organization), GO:0051148 (negative regulation of muscle cell differentiation), GO:0090257 (regulation of muscle system process), GO:1903522 (regulation of blood circulation), GO:0007420 (brain development), GO:0045744 (negative regulation of G protein-coupled receptor signaling pathway), GO:1902903 (regulation of supramolecular fiber organization), GO:0055021 (regulation of cardiac muscle tissue growth), GO:0060420 (regulation of heart growth), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0007399 (nervous system development), GO:0031644 (regulation of nervous system process), GO:0010460 (positive regulation of heart rate), GO:0061050 (regulation of cell growth involved in cardiac muscle cell development), GO:0007417 (central nervous system development), GO:0043085 (positive regulation of catalytic activity), GO:2000463 (positive regulation of excitatory postsynaptic potential), GO:0010614 (negative regulation of cardiac muscle hypertrophy), GO:0051956 (negative regulation of amino acid transport), GO:0051952 (regulation of amine transport), GO:0043278 (response to morphine), GO:0051336 (regulation of hydrolase activity), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0050804 (modulation of chemical synaptic transmission), GO:0051147 (regulation of muscle cell differentiation), GO:0043267 (negative regulation of potassium ion transport), GO:0055022 (negative regulation of cardiac muscle tissue growth), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0032890 (regulation of organic acid transport), GO:0010611 (regulation of cardiac muscle hypertrophy), GO:0033043 (regulation of organelle organization), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0051154 (negative regulation of striated muscle cell differentiation), GO:0051493 (regulation of cytoskeleton organization), GO:0045471 (response to ethanol), GO:0010959 (regulation of metal ion transport), GO:0043087 (regulation of GTPase activity), GO:0008016 (regulation of heart contraction), GO:1901380 (negative regulation of potassium ion transmembrane transport), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0051345 (positive regulation of hydrolase activity), GO:0010958 (regulation of amino acid import across plasma membrane), GO:0043279 (response to alkaloid), GO:0014072 (response to isoquinoline alkaloid), GO:0014743 (regulation of muscle hypertrophy), GO:0051955 (regulation of amino acid transport), GO:0014075 (response to amine), GO:0051153 (regulation of striated muscle cell differentiation), GO:1904063 (negative regulation of cation transmembrane transport), GO:0110053 (regulation of actin filament organization), GO:1901379 (regulation of potassium ion transmembrane transport), GO:0043547 (positive regulation of GTPase activity), GO:0043266 (regulation of potassium ion transport), GO:0051924 (regulation of calcium ion transport), GO:0001975 (response to amphetamine)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)