Protein: Transcription factor MAR1 (Q6FXJ5)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
Function: Transcription factor that contributes to plasma membrane sphingolipid incorporation and membrane permeability, decreasing fluconazole accumulation. Regulates 337 genes under fluconazole stress, including several related to lipid biosynthesis pathways such as RSB1, encoding a sphingoid long-chain base efflux transporter. Associates with the promoter of RSB1 in the region containing two 5'-CCCCTCC-3' motifs and increases its promoter occupancy upon fluconazole stress
Subcellular location: Nucleus
Sequence: MSTTTTIPGAAPKKKRNRIPLSCTICRKRKVKCDKTRPHCNQCTKTGVAHLCHYMEQNWAQDAKKEISKDNELKNLKERCKILEEKLARYMHNPAVTASLGASVVNSPVGLSSPVDAPIKLTNSPMVKLEDDTNMVDDMARPVKEHDYDELDLTRQFDLLHIKSNGTIHLGATHWLAIMKGDPYLKLLWTHIFTMREKLLEYYTNGSGHKRRKRQKNGGKCPIDHSKFKAAESEQKNHFVKTTPMVNDTPKSSIGKCPIDHRAMSNPVGVNSNAGQFQPMHPPHTHIVQNKCPVDHKVNDSNLTSANTDNKNAATKKCPINHSKYTKEKMQGAGLNDKPLTKQEVIEKLCQLLPPKRIIMLYIDKFFKHFYPVIPILDELNFKNNINQIFDLNSLISNTIMSTSSDLELEPITSMTLNKPTDYSNLGILIIIMRLVWLSLPMNSCKIDIENPLLNKLRTDHDFKNEDYESGSLASSLRLKDELQLLKYEVDGFALDLVKKHLIKFDEISSISNTNVNMSTIQFAVFFKFYLMNCANASSQGNSAGNFDNESHQILLSSIMMMAFSCGLHRDPDNFPQLNVVSANLTTDNTRSGPPSNSNRNGSETPSVSPKDTNVSIERAKHTWRKVWYYIVSLDVQQSLLLGSPRLIRNLNDISDTKLPSASKIDYVKDIKELIIIKNYTLFYQLDLCIVAVLNHTLNISIAKNVRKFELDALISNLQKLTDGEKGINDVINSLINHGLLSTSEVPIGLQKFDDIYDLPRMEDILLARKSEQEIVGDENERIGQDVDKKLDLPHEMTSKALFFSKHMTLRMLLYLLNYILFTHYEPLGAEDPTTTILAKNYAQKALDYALDGYRNCMLYFVGVSDQNPLFKYMNVILCFHSLDIGHRALQFIICLILRVKCGPLNGLKETQTIFGTSVPSSCNSSSVEDENTEEPNNLNQDNQFQDDLMQNINLDNSDSLAEKLMSRMVLFKQLTEKLAPKYSFSVRVMKSTGFFISLLTTPSGSFGSKKNGSKHKHGVGKLLLSNWKHPKISNIPALLSSDSDQLKKCPVYQDALGFMPSRPSVTNLPSISNVEGLLPNAQANGRMTPQLPPIRSYQPITYSSSHMRVTPNSESDARKLGPDSHQVTNPLIPSPLSPANQQQNQVNVLHMHQQRSMSPAPMPMMNPTAMTTNQNMIPERKYAPHSGAATPILPGTNSDIQQQTQMTRNDPYPTEQFSLPPISSAKNNMAWGTTPESEQGDHLTPNTTTSSLDTPDFEDFIIQNSNFNGLLINPNSLAEAMGSLPSGRDGAILNVNSFKDFTTSTNDKTITPNSADQTDLFSVDMASTDFLPIDNFAIDGFMDSANLDIGSIWE
InterPro domains: - IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [57-89]
- IPR036864: Zn(2)-C6 fungal-type DNA-binding domain superfamily (homologous_superfamily) [12-59]
- IPR001138: Zn(2)Cys(6) fungal-type DNA-binding domain (domain) [17-63]
- IPR007219: Xylanolytic transcriptional activator, regulatory domain (domain) [363-666]
- IPR051430: Fungal Transcription Factors for Environmental Response (family) [11-1176]
Interaction partners: - Candida glabrata strain CBS138 chromosome D complete sequence
- Histone H4
- Candida glabrata strain CBS138 chromosome G complete sequence
- Sphingoid long-chain base transporter RSB1
- Candida glabrata strain CBS138 chromosome B complete sequence
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0003677 (DNA binding), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)