Protein: Serine/threonine transporter SstT (Na(+)/serine-threonine symporter) (P0AGE4)
Organism: Escherichia coli (strain K12)
Function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01582, ECO:0000269|PubMed:15919996}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01582}.
Sequence: MTTQRSPGLFRRLAHGSLVKQILVGLVLGILLAWISKPAAEAVGLLGTLFVGALKAVAPILVLMLVMASIANHQHGQKTNIRPILFLYLLGTFSAALAAVVFSFAFPSTLHLSSSAGDISPPSGIVEVMRGLVMSMVSNPIDALLKGNYIGILVWAIGLGFALRHGNETTKNLVNDMSNAVTFMVKLVIRFAPIGIFGLVSSTLATTGFSTLWGYAQLLVVLVGCMLLVALVVNPLLVWWKIRRNPFPLVLLCLRESGVYAFFTRSSAANIPVNMALCEKLNLDRDTYSVSIPLGATINMAGAAITITVLTLAAVNTLGIPVDLPTALLLSVVASLCACGASGVAGGSLLLIPLACNMFGISNDIAMQVVAVGFIIGVLQDSCETALNSSTDVLFTAAACQAEDDRLANSALRN
InterPro domains: - IPR023025: Serine/threonine transporter SstT (family) [6-407]
- IPR036458: Sodium:dicarboxylate symporter superfamily (homologous_superfamily) [8-406]
- IPR001991: Sodium:dicarboxylate symporter (family) [18-408]
Interaction partners: - Serine transporter SdaC
- D-serine/D-alanine/glycine transporter
- Threonine/serine transporter TdcC
- Dipeptide-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015141 (succinate transmembrane transporter activity), GO:0015556 (C4-dicarboxylate transmembrane transporter activity), GO:0015293 (symporter activity), GO:0005310 (dicarboxylic acid transmembrane transporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity), GO:0015172 (acidic amino acid transmembrane transporter activity), GO:0015183 (L-aspartate transmembrane transporter activity), GO:0015295 (solute:proton symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006835 (dicarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)