Protein: CMRF35-like molecule 7 (CLM-7) (CD300 antigen-like family member B) (CMRF35-A2) (Immune receptor expressed on myeloid cells 3) (IREM-3) (Leukocyte mono-Ig-like receptor 5) (Triggering receptor expressed on myeloid cells 5) (TREM-5) (CD antigen CD300b) (A8K4G0)
Organism: Homo sapiens (Human)
Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Sequence: MWLPPALLLLSLSGCFSIQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNHYMLLVFVKVPILLILVTAILWLKGSQRVPEEPGEQPIYMNFSEPLTKDMAT
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [19-120]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [18-123]
- IPR050671: CD300 family immune receptors (family) [1-169]
- IPR007110: Immunoglobulin-like domain (domain) [5-120]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [13-135]
- IPR003599: Immunoglobulin domain subtype (domain) [21-122]
Interaction partners: - TYRO protein tyrosine kinase-binding protein
- CMRF35-like molecule 6
- CMRF35-like molecule 1
- Hematopoietic cell signal transducer
- CMRF35-like molecule 8
- High affinity immunoglobulin epsilon receptor subunit gamma
- CMRF35-like molecule 2
- Triggering receptor expressed on myeloid cells 1
- CMRF35-like molecule 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0051239 (regulation of multicellular organismal process), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0002696 (positive regulation of leukocyte activation), GO:0043207 (response to external biotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0002443 (leukocyte mediated immunity), GO:0002694 (regulation of leukocyte activation), GO:1901700 (response to oxygen-containing compound), GO:0050865 (regulation of cell activation), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0050867 (positive regulation of cell activation), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0033003 (regulation of mast cell activation), GO:0002444 (myeloid leukocyte mediated immunity), GO:0002237 (response to molecule of bacterial origin), GO:1901701 (cellular response to oxygen-containing compound), GO:0033005 (positive regulation of mast cell activation), GO:0071222 (cellular response to lipopolysaccharide), GO:0002446 (neutrophil mediated immunity), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)