Protein: Nitric oxide synthase (EC 1.14.13.39) (B3VK56)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004468}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004468}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}.
Sequence: MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQVDRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [4-126]
- IPR001433: Oxidoreductase FAD/NAD(P)-binding (domain) [1251-1363]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [995-1242]
- IPR044943: Nitric oxide synthase, domain 1 superfamily (homologous_superfamily) [319-684]
- IPR012144: Nitric-oxide synthase, eukaryote (family) [80-1427]
- IPR023173: NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily (homologous_superfamily) [989-1176]
- IPR001094: Flavodoxin-like (domain) [761-924]
- IPR036119: Nitric oxide synthase, N-terminal domain superfamily (homologous_superfamily) [305-721]
- IPR003097: Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding (domain) [991-1219]
- IPR001478: PDZ domain (domain) [17-100]
- IPR050607: Nitric Oxide Synthase (NOS) (family) [274-1429]
- IPR001709: Flavoprotein pyridine nucleotide cytochrome reductase (domain) [1032-1358]
- IPR029039: Flavoprotein-like superfamily (homologous_superfamily) [747-955]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [1238-1402]
- IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [969-1236]
- IPR044940: Nitric oxide synthase, domain 2 superfamily (homologous_superfamily) [436-547]
- IPR044944: Nitric oxide synthase, domain 3 superfamily (homologous_superfamily) [548-658]
- IPR004030: Nitric oxide synthase, N-terminal (domain) [357-717]
- IPR008254: Flavodoxin/nitric oxide synthase (domain) [760-940]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0043177 (organic acid binding), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0043168 (anion binding), GO:0044325 (transmembrane transporter binding), GO:0043169 (cation binding), GO:0031406 (carboxylic acid binding), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0051051 (negative regulation of transport), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0044237 (cellular metabolic process), GO:0033555 (multicellular organismal response to stress), GO:0140253 (cell-cell fusion), GO:0044281 (small molecule metabolic process), GO:0006949 (syncytium formation), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009266 (response to temperature stimulus), GO:0001666 (response to hypoxia), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0045454 (cell redox homeostasis), GO:0030154 (cell differentiation), GO:0051282 (regulation of sequestering of calcium ion), GO:0032409 (regulation of transporter activity), GO:0060341 (regulation of cellular localization), GO:0044248 (cellular catabolic process), GO:0070482 (response to oxygen levels), GO:0044057 (regulation of system process), GO:0034762 (regulation of transmembrane transport), GO:0060255 (regulation of macromolecule metabolic process), GO:0001505 (regulation of neurotransmitter levels), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0003013 (circulatory system process), GO:0034763 (negative regulation of transmembrane transport), GO:0009408 (response to heat), GO:0061061 (muscle structure development), GO:0042133 (neurotransmitter metabolic process), GO:0000768 (syncytium formation by plasma membrane fusion), GO:0031325 (positive regulation of cellular metabolic process), GO:0010522 (regulation of calcium ion transport into cytosol), GO:0006082 (organic acid metabolic process), GO:0051481 (negative regulation of cytosolic calcium ion concentration), GO:0043271 (negative regulation of monoatomic ion transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0090066 (regulation of anatomical structure size), GO:0003018 (vascular process in circulatory system), GO:0010562 (positive regulation of phosphorus metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0007520 (myoblast fusion), GO:0008015 (blood circulation), GO:0051246 (regulation of protein metabolic process), GO:0043436 (oxoacid metabolic process), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0090257 (regulation of muscle system process), GO:1901605 (alpha-amino acid metabolic process), GO:1903522 (regulation of blood circulation), GO:0035150 (regulation of tube size), GO:0016054 (organic acid catabolic process), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0042692 (muscle cell differentiation), GO:0036293 (response to decreased oxygen levels), GO:0009063 (amino acid catabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0051926 (negative regulation of calcium ion transport), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:0051174 (regulation of phosphorus metabolic process), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0006937 (regulation of muscle contraction), GO:0009065 (glutamine family amino acid catabolic process), GO:0031399 (regulation of protein modification process), GO:0009064 (glutamine family amino acid metabolic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:1904063 (negative regulation of cation transmembrane transport), GO:0010959 (regulation of metal ion transport), GO:0019220 (regulation of phosphate metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0097746 (blood vessel diameter maintenance), GO:0008016 (regulation of heart contraction), GO:0051146 (striated muscle cell differentiation), GO:0035296 (regulation of tube diameter), GO:1903170 (negative regulation of calcium ion transmembrane transport), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1901606 (alpha-amino acid catabolic process), GO:0031401 (positive regulation of protein modification process), GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity), GO:0042325 (regulation of phosphorylation), GO:0055117 (regulation of cardiac muscle contraction), GO:0006527 (arginine catabolic process), GO:0001932 (regulation of protein phosphorylation), GO:2001257 (regulation of cation channel activity), GO:0042311 (vasodilation), GO:0006942 (regulation of striated muscle contraction), GO:0014902 (myotube differentiation), GO:0051924 (regulation of calcium ion transport), GO:0042327 (positive regulation of phosphorylation), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0001934 (positive regulation of protein phosphorylation), GO:0006525 (arginine metabolic process), GO:0033138 (positive regulation of peptidyl-serine phosphorylation), GO:0033135 (regulation of peptidyl-serine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle), GO:0042383 (sarcolemma), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)