Protein: Delta-1-pyrroline-5-carboxylate synthase B (P5CS B) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] (P54888)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants.
Sequence: MTEIDRSRAFAKDVKRIVVKVGTAVVTGKGGRLALGRLGAICEQLAELNSDGFEVILVSSGAVGLGRQRLRYRQLVNSSFADLQKPQMELDGKACAGVGQSSLMAYYETMFDQLDVTVAQMLVTDSSFRDKDFRKQLSETVKAMLRMRVIPVFNENDAISTRRAPYKDSTGIFWDNDSLAALLSLELKADLLILLSDVEGLYTGPPSDSTSKLIHTFIKEKHQDEITFGEKSKLGRGGMTAKVKAAVNAAYGGVPVIITSGYAAENISKVLRGLRVGTLFHQDAHLWAPVVDTTSRDMAVAARESSRKLQALSSEDRKQILHDIANALEVNEKTIKAENDLDVAAAQEAGYEESLVARLVMKPGKISSLAASVRQLAEMEDPIGRVLKKTQVADDLILEKTSSPIGVLLIVFESRPDALVQIASLAIRSGNGLLLKGGKEARRSNAILHKVITDAIPETVGGKLIGLVTSREEIPDLLKLDDVIDLVIPRGSNKLVSQIKNSTKIPVLGHADGICHVYVDKSGKLDMAKRIVSDAKLDYPAACNAMETLLVHKDLEQNGFLDDLIYVLQTKGVTLYGGPRASAKLNIPETKSFHHEYSSKACTVEIVEDVYGAIDHIHQHGSAHTDCIVTEDSEVAEIFLRQVDSAAVFHNASTRFSDGFRFGLGAEVGISTSRIHARGPVGVEGLLTTRWIMRGKGQVVDGDNGIVYTHKDLPVLQRTEAVENGI
InterPro domains: - IPR001048: Aspartate/glutamate/uridylate kinase (domain) [15-260]
- IPR015590: Aldehyde dehydrogenase domain (domain) [298-564]
- IPR000965: GPR domain (domain) [294-700]
- IPR036393: Acetylglutamate kinase-like superfamily (homologous_superfamily) [4-286]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [297-699]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [303-698]
- IPR005715: Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase (family) [15-284]
- IPR041744: Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain (domain) [7-281]
- IPR020593: Gamma-glutamyl phosphate reductase GPR, conserved site (conserved_site) [607-628]
- IPR005766: Delta l-pyrroline-5-carboxylate synthetase (family) [1-723]
- IPR001057: Glutamate/acetylglutamate kinase (family) [52-254]
- IPR019797: Glutamate 5-kinase, conserved site (conserved_site) [232-249]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [512-658]
Interaction partners: - Delta-1-pyrroline-5-carboxylate synthase A
- Ornithine aminotransferase, mitochondrial
- Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial
- Pyrroline-5-carboxylate reductase
- Glutamate synthase 1, chloroplastic
- Glutamate dehydrogenase 2
- glutamate dehydrogenase
- Glutamate dehydrogenase 1
- Probable glutamate dehydrogenase 3
- Proline dehydrogenase 1, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016301 (kinase activity), GO:0016774 (phosphotransferase activity, carboxyl group as acceptor), GO:0019202 (amino acid kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0001101 (response to acid chemical), GO:0099402 (plant organ development), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009415 (response to water), GO:0044283 (small molecule biosynthetic process), GO:0006979 (response to oxidative stress), GO:0006082 (organic acid metabolic process), GO:0048731 (system development), GO:0006970 (response to osmotic stress), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006520 (amino acid metabolic process), GO:0048229 (gametophyte development), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:1901566 (organonitrogen compound biosynthetic process), GO:0048364 (root development), GO:0009555 (pollen development), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0009651 (response to salt stress), GO:0006972 (hyperosmotic response), GO:1901605 (alpha-amino acid metabolic process), GO:0022622 (root system development), GO:0019752 (carboxylic acid metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0042538 (hyperosmotic salinity response), GO:0046394 (carboxylic acid biosynthetic process), GO:0006560 (proline metabolic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0006561 (proline biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)