Protein: SLIT-ROBO Rho GTPase-activating protein 2 (B0S6J3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation
Subcellular location: Cell membrane. Cell projection, dendritic spine. Postsynaptic density. Postsynaptic cell membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome. Nucleus. Cytoplasm, cytosol
Sequence: MTSPAKFRKDKEIIAEYETQVKEIRAQLVEQLKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRYTKDPQFKKEQNILSPVNCWNLLLAQVKRESRDHATLSDLYLNNIIPRFAQISEDSGRLFKKSKEVGLQLQEDLMKVLNELYTVMKTYHMYNMDSINAESKLKEAEKQEEKQMSRSVRHEEKQTPRSPDSLTNIKIEDKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNSCVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEFNVETSKHGGLETIENAAENLEANSDKQRLMETYNNVFCPPMRFDFQSHMGDMVGHLCAQQPVQGELIQRCQQLQSRLSTLNIENEEVKKTMEATLQTIQDMVTIEDFDVTDCFHHSNSMESVKSTVSESFMSKPSLAKRRANQQETEQFYFTKLKEFLEGRNLITKLQAKHDLIQKTLGESQKTDYCLASGRRDSTVRKQEAIQIIPLMVESCIRFISRHGLHHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLENALFPKEVFHDLMSCVSIESLQERAVHIRKVLLSLPSNILVIMRYLFAFLNHLSQYSDDNMMDPYNLAICFGPTLMSVPEGHDQVSCQAHVNELIKTIIIHHESIFPGPRELEGPVYDRGGAPEEYCDSPHIEPPLVDEPAPDTVSVIHNSDDVKSGPLTVSESDPIEAIARFDYSGRTNRELSFKKGASLLLYSRASDDWWEGRHNGTEGLVPHQYIVVQDMPDGYAGRGSPKADLEGSHDSVEEKVSTRASASSPTGGHVADIYLANLNKLRKRPEATSIRRTIRPVEEGSSGAAGGLKTSSMPAGGLAKDSSDKRPVSAHSVLNSITRHSSLKTKVEGPQVRKSTPTGRSKSFSNHRPLDPEVIAQVEHSSQDIEATMNTALSELRELERQSNVKHAPDVVLDTLEQLKSGGTSEPSSPLHSRLLREAESSQHPLQRSASSASDMPSTFRPSKTTGPKSPLSSMTTASGSTFRDNKPPATRPKPVVFPKSSSAGGSPAMGSPTTTIPPTPPPPPPPTDKSCPV
InterPro domains: - IPR001060: FCH domain (domain) [22-120]
- IPR051627: SLIT-ROBO Rho GTPase-activating (family) [6-1040]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [739-797]
- IPR031160: F-BAR domain (domain) [19-324]
- IPR000198: Rho GTPase-activating protein domain (domain) [496-680]
- IPR001452: SH3 domain (domain) [738-797]
- IPR035648: srGAP1/2/3, SH3 domain (domain) [742-794]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [24-347]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [382-690]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0071840 (cellular component organization or biogenesis), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0016358 (dendrite development), GO:0051014 (actin filament severing), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0016043 (cellular component organization), GO:0060996 (dendritic spine development), GO:0016477 (cell migration), GO:0031589 (cell-substrate adhesion), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0051336 (regulation of hydrolase activity), GO:0030334 (regulation of cell migration), GO:0043085 (positive regulation of catalytic activity), GO:0034330 (cell junction organization), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0048666 (neuron development), GO:0001667 (ameboidal-type cell migration), GO:0034446 (substrate adhesion-dependent cell spreading), GO:0030336 (negative regulation of cell migration), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0043087 (regulation of GTPase activity), GO:2001222 (regulation of neuron migration), GO:0031175 (neuron projection development), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0048699 (generation of neurons), GO:0030031 (cell projection assembly), GO:0050808 (synapse organization), GO:0051345 (positive regulation of hydrolase activity), GO:0120036 (plasma membrane bounded cell projection organization), GO:0034329 (cell junction assembly), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0097581 (lamellipodium organization), GO:1904862 (inhibitory synapse assembly), GO:1904861 (excitatory synapse assembly), GO:0043547 (positive regulation of GTPase activity), GO:0030032 (lamellipodium assembly), GO:0046847 (filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)