Protein: Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3] (P69525)
Organism: Mus musculus (Mouse)
Function: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Sequence: MEPTAPDLQLVPEVTKAVSVSAPDPGPCRTAVIAVVGISMAIVTLGVLSAFFSAQGAHVEHIAELHGIRFTSSLQQENSDFYRLLTHALQTLLHFLLRALQPLSLKQEADILQKGIQARLQEQGLSLAAYGTIVSVELTGRCEGPVTERDLKSGHCPGNVFSCQNGQCVSKENPECDDRVDCSDESDEAQCDCGWQPAWRSAGRIVGGVEAAPGEFPWQVSLRENHEHFCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRTRVLRIAKHPAYDADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYTRVTRLRDWILEVTSAADMPVVPTATPAPATPSTPWPTSPESWAPNTFAKPTAAPSPVPLHPSTTAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGPRHFCGATVVGDRWLLSAAHCFNHTKVEQVQAHLGTVSLLGVGGSPVKLGLRRVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQKASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSMARPHTSSTRLIPSEPPKTTAAGLIIPEATTSRLATPRATIRVTTRPLNTTLSARSTTTRGQTAAPSAPGTTIHSHLPDCGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDIYGDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPARPPDGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWIGQNIQE
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [231-394]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [198-1064]
- IPR017324: Transmembrane protease serine 9 (family) [1-1065]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [241-876]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [383-694]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [151-193]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [181-1064]
- IPR001254: Serine proteases, trypsin domain (domain) [204-1064]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [155-193]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0009653 (anatomical structure morphogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0009887 (animal organ morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0097186 (amelogenesis), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0048513 (animal organ development), GO:0009057 (macromolecule catabolic process), GO:0045229 (external encapsulating structure organization), GO:1901565 (organonitrogen compound catabolic process), GO:0043062 (extracellular structure organization), GO:0022411 (cellular component disassembly), GO:0030163 (protein catabolic process), GO:0042476 (odontogenesis), GO:0022617 (extracellular matrix disassembly), GO:0030198 (extracellular matrix organization), GO:0042475 (odontogenesis of dentin-containing tooth)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)