Protein: Serine/threonine-protein kinase 4 homolog B (EC 2.7.11.1) (Kinase responsive to stress B) (STE20-like kinase krsB) (Q55FS2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable serine/threonine-protein kinase.
Sequence: MEESGQLSDFKLPEGIKDPSLEFDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNITNRVLNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQEVGYDNKADIWALGISAIEMAEFHPPYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFFEKKLKGSYVMKSLSETAQMVIERCGGREEAVKAAAERKSKQSGVSVDFIHCESVDEPDSSDEEDLLERNNKRLSTQIQQKKEQQAQQQQQQAQQQQQQQQQQQQQYQPPSPNNNNRTTTKNNDINELDSLLNNMMMSSSASASTSPSPSSISSNGNKSGTTTNDYHTGNGRTSSSSPQFGLQHQNSSNSFPSSPNTVPSVESKPRQPASELDDLLEEMMNPSFGNRARNSSGGGGGLTPIGSPITKRPTPTMQSSTTTTTSSSSLPLPMSPSVYLSPTRVSGIWSGESAGGCANTTLWRKNPQYLLQITATTTIRITLRQTGDKLVHIGFYFARSNTGANDQFRRRITLTKEYLVPGLDITFLKSTEVSAKITMEPGYYVIIPATFEPNQEGSFELDVTATSDNIGGQYNSNNNIKLSEIKGDRDWRIISDRFEWRGSSAGGSFSGSSATWKDNPKFFFETTQTSNTTIVLGKLSDIPKETYIGFYIFKADKNCPFISLTANNLYSKTSFVNGIEVVHTQQQMPPGCYIIVPCTYDSRQEGSFTLTCYSDCQQGSIYKLDLSEQILTVHGEWRGATSGGCLNHTTWRNNAQYLIHNTSSSPTKVTIMLEQLEKMDNQQLPFVGFYVAKSPTPNLDKKLFSLTPKDIVGNTEFINDYQVHFTSIMEPNTSYIIIPSTFTPGIEYPFNLRVITNQHNVIQISRLPEWSTRKLSGEWRGQSCGGRYSNTSSSWTLNPRFRFNLPRGGRFTIILAQAEKPSYNGIGFYYFKTLQDGTLREFVCKSGFICGKEIVLESSINEGVTGVVIPSTFEPNIQDSFNLTIYSEFDLDFYNN
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [22-449]
- IPR022683: Peptidase C2, calpain, domain III (domain) [548-1103]
- IPR036213: Calpain large subunit, domain III superfamily (homologous_superfamily) [552-1103]
- IPR050629: STE20/SPS1-related Proline-Alanine-rich Kinase (family) [18-496]
- IPR022682: Peptidase C2, calpain, large subunit, domain III (domain) [555-1095]
- IPR017441: Protein kinase, ATP binding site (binding_site) [29-52]
- IPR000719: Protein kinase domain (domain) [23-274]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:1903665 (negative regulation of asexual reproduction), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0042330 (taxis), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0099120 (socially cooperative development), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032506 (cytokinetic process), GO:0000910 (cytokinesis), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1903047 (mitotic cell cycle process), GO:0030154 (cell differentiation), GO:0031152 (aggregation involved in sorocarp development), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0006970 (response to osmotic stress), GO:0051649 (establishment of localization in cell), GO:0032101 (regulation of response to external stimulus), GO:0051098 (regulation of binding), GO:0030036 (actin cytoskeleton organization), GO:0030587 (sorocarp development), GO:0044087 (regulation of cellular component biogenesis), GO:0000902 (cell morphogenesis), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0016043 (cellular component organization), GO:0031668 (cellular response to extracellular stimulus), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0071496 (cellular response to external stimulus), GO:0090066 (regulation of anatomical structure size), GO:0000278 (mitotic cell cycle), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:0030030 (cell projection organization), GO:0009267 (cellular response to starvation), GO:0051336 (regulation of hydrolase activity), GO:0032956 (regulation of actin cytoskeleton organization), GO:1902532 (negative regulation of intracellular signal transduction), GO:1903667 (regulation of chemorepellent activity), GO:0043393 (regulation of protein binding), GO:0032104 (regulation of response to extracellular stimulus), GO:0051099 (positive regulation of binding), GO:1902903 (regulation of supramolecular fiber organization), GO:1903669 (positive regulation of chemorepellent activity), GO:0050923 (regulation of negative chemotaxis), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0031667 (response to nutrient levels), GO:0043085 (positive regulation of catalytic activity), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0031669 (cellular response to nutrient levels), GO:1902531 (regulation of intracellular signal transduction), GO:0000281 (mitotic cytokinesis), GO:2000273 (positive regulation of signaling receptor activity), GO:0051493 (regulation of cytoskeleton organization), GO:0032092 (positive regulation of protein binding), GO:0051346 (negative regulation of hydrolase activity), GO:0051494 (negative regulation of cytoskeleton organization), GO:0032271 (regulation of protein polymerization), GO:0030837 (negative regulation of actin filament polymerization), GO:0030832 (regulation of actin filament length), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007010 (cytoskeleton organization), GO:0043087 (regulation of GTPase activity), GO:0032107 (regulation of response to nutrient levels), GO:0006897 (endocytosis), GO:0032107 (regulation of response to nutrient levels), GO:0051345 (positive regulation of hydrolase activity), GO:0110053 (regulation of actin filament organization), GO:0014074 (response to purine-containing compound), GO:1903013 (response to differentiation-inducing factor 1), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0140582 (adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway), GO:0043547 (positive regulation of GTPase activity), GO:1900122 (positive regulation of receptor binding), GO:0030833 (regulation of actin filament polymerization), GO:0090630 (activation of GTPase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)