wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Fusexin 1 (P0DW65)
Organism: Haloplanus natans (strain DSM 17983 / JCM 14081 / CGMCC 1.8972 / RE-101)
Function: Exhibits fusogenic activity. Mediates cell- cell fusion in mammalian cells (bilateral fusion)
Subcellular location: Cell surface. Cell membrane; Multi-pass membrane protein
Sequence: MKRVGNCWKASVAAFFLLMFTAFAAADTTSVDTVSYKSNSEFFDGEVLQAGYVSNFATDKINVHLGASEIESKTGATAEEDLTLSVSHQNTYARYPLQETGLKKIYGWEGMKKTFDTKDQLWNWVTSNCADFTEGGVAIGDRTSKVEAAAKSWYDYWTGSYNYQAFCLRKNGYYGDVADIGSPDEIFRTEWRLQAGDKNPQTAIITNGDGGSGVVSNLGRYAKVKWQGNLDTGQNPPLVDDELAIHGNNYEGGWRVISEQRYDNYWNYIKNDGNRLLDKWKSGDYSESYIEGLLNGKAENAQKRYSESPLANAEVLDSSFQSGALKADMDSRLAYPEFNVYVDAGENGYITVSKPVGKPKIVSSSGASFGELSSGRISVDVKNVGGAEGSFSARAGSCSQYFQADALQNTKRVAPGETASYSFRVTFTSTSMQQASYTGRCSITVEDTGSGREVSTSVSVEATQQSECTQGKEIVKQKNGNDVIYSCPDGLKIQKQDTCTGELKAVFVNNDIQYDCREEGTGGGSGGGLFGKRFTLPITGTQLSNPLNAFENIWSGDANALNWLQVFVTFIAFLGGFALVGVKLGKIVDGLATEFIPVKDSHVRLVIGLLGGGMIATAVYQLVTDPLGLLVTVLGLVVMGYLYLSASAPEINL
InterPro domains: - IPR049902: Fusexin 1 (family) [8-628]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0019049 (mitigation of host antiviral defense response), GO:0030682 (mitigation of host defenses by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033655 (host cell cytoplasm part), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0044165 (host cell endoplasmic reticulum), GO:0042025 (host cell nucleus)
Protein: Fusexin 1 (L9ZES0)
Organism: Natrinema altunense (strain JCM 12890 / CGMCC 1.3731 / AJ2)
Function: Exhibits fusogenic activity. Mediates cell- cell fusion in mammalian cells (bilateral fusion)
Subcellular location: Cell surface. Cell membrane; Multi-pass membrane protein
Sequence: MRAVSDFLKNKWVAVPAVALLILSLGFLAQNYITGSFVSGDQIEYTSNSEFFDGEVFVINYIGDRTTDKIHAEIPASELASAADGEVTKELTIDITSQETYARYSTTSTSLSRIYAFKAINSEVFTDTSSSEVESRKQSWAEQNCYDIDGDSEIEQGDDYTQRFWVDGAIADYYNAQVYCVRENGYYGNIAELSSPDKEFEAEVEVKADGETPQSTTLSNSDLGQGRCDNIGEYVRACWTGLNPTGEGVPEPYNVYAIHSNTFSPEWRVISAERYSSYNSYVENNLYSQIEAWKEGSLSQEEVVSTANDQAAQAAQRVSSGSFTDYQVEDSSYENGQIRLNPSYDIAWPEFTFYVDGADYISVEKPVGEPRIVNVEGDEFGEKQSGTVTAEVENTASYEGSFSARVSKCSDSFGYDSLQETKTVGPGETVSFDFRVSFTSDSFDQKTVSGSCEIVVSDTGDSSNSDTAVVDVEATQSNECTPNEEFVRTINSTHSRILECSSDGLTTTEVDVCGDGEEAAFRDSSWTCVSDGTLPGGGDGSGGSGGGGDTDDCVVFAVGDLEIEDPFCADGPLEMLSKMFHLVAGTAVAFFTGSLGYRAGRWVDGEYQIKGGFDPLKSRSVSRAKRGRFLIGLIAELVSFLLGFYVILLVPIWAQLMVILGYVLFKYYTPF
InterPro domains: - IPR049902: Fusexin 1 (family) [17-643]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033655 (host cell cytoplasm part), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0044165 (host cell endoplasmic reticulum), GO:0042025 (host cell nucleus)
Protein: Fusexin 1 (C0HM55)
Organism: Uncultured archaeon
Function: Exhibits fusogenic activity. Mediates cell- cell fusion in mammalian cells when present in both cells (bilateral fusion)
Subcellular location: Cell surface. Cell membrane; Multi-pass membrane protein
Sequence: MRRAALILAFVLFIGLSSATVTSADSITYNSGTSEFFDGDVFAIEVTADQSTDEIDIYLGASELSEKTDGEVNQDLSIEFTHQDSKLKYSTSTSDELRDIVTLTTYYEDGFDTEQDAIDAIKSDCYDLNQNGNGSGRYSRYYSVTSPVYDYEIYCFQKNEKLATPAYIDNPDEIFTAKAELQAGDKTIQSATLSNGDAGDGTVTDLGDSKISWNGNLDLGASEPENSRVIALYSNDFENGWRIGNKQSYEDYKTFIGGGDAYDLLIDWQDGTYTASEVEDELVNTDANQAVEEASSSTTDLVNAKVKDSSLDTGSFVYDTPELLSYPSFTVYVDAGENGYIEVTKPTGDPDIISTSSTEIKEGDEGTVTATVENVGDGEGEFSGRLSSCGEGFSIVDDQNTKNVGAGESVTYSFDVAFSSVSSESKEISGSCTFEVNGVESSDSTSVSVTGIQQSECNPGDQRREKNENDRWEIYTCQDNGLTYEYDVTCAEDEKAVAQGDNQFSCEKQDDDSGGGDNTGSDSGLFSNLFGGSGSGDLLTQVHTALSILAGLVAGFFGYRGARWIHGETDIKGGFKLESRNVSRVKRGSPVAGIVGAVLGFVVGYGVASVFHPVVQIIVVLGIAVGLYYFR
InterPro domains: - IPR013783: Immunoglobulin-like fold (homologous_superfamily) [350-470]
- IPR049902: Fusexin 1 (family) [2-604]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006353 (DNA-templated transcription termination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033655 (host cell cytoplasm part), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0044165 (host cell endoplasmic reticulum), GO:0042025 (host cell nucleus)
Protein: GRB2-associated-binding protein 3 (Q8BSM5)
Organism: Mus musculus (Mouse)
Sequence: MSTGDTVCMGWLIKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSNKPIRVIDLSECTVWKHAGPGFIRKEFQKNFVFIVKTTSRTFYLVAKTEEEMQVWVHSISQVCNFSHLEDGADSMESLSHMPSSFQPSPASSLHTVHVANSALLKDDRNTNSVVTEETRRESEFLFLPDYLILSNCETGRLHHASLPTRCDSWSNSNHSLAQTSFDDVFLDGLQPFISNNLVHPLHHGKVSQDFPSIRPQASLIWNREINGPSRNLMSSSPLLESSLNPTVHVEEKQVSLPSGVKELNIMSNTPPPRPPKPSYLSEQRQDQPLLTGHSSNKKPGYTMVPRRISLSGLDHVGSWKGDVQSQSLRHRDKRLSLNLPCKFSPIYPTASPSAEDSYVPMSPKGTASELRPHCSQDDYIPMSSSMLPELPADLEPPPVNRNLKPQRKSRPPPLDSRNLSTIQEHTSLTRTYTVPCNRTSFLSPQRNGINCARLFSTPSEEEEEEEEEEEEEEEEEKYIQMEEYGTVSSLSRSALSWTKKFSLDYLALDFNSTSPAPVQKKLLLSEEQRVDYVQVDEQKTQALRSTKQEWTDERQSKV
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [5-119]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1-128]
- IPR046355: GRB2-associated-binding protein 1-4-like (family) [1-594]
Interaction partners: - Growth factor receptor-bound protein 2
- Tyrosine-protein phosphatase non-receptor type 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0030097 (hemopoiesis), GO:0030099 (myeloid cell differentiation), GO:0002521 (leukocyte differentiation), GO:0002573 (myeloid leukocyte differentiation), GO:0030225 (macrophage differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: D-tagatose-1,6-bisphosphate aldolase subunit GatY (P0C8J6)
Organism: Escherichia coli (strain K12)
Function: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. Has a high aldolase activity for TBP and a very low one for fructose 1,6-bisphosphate (FBP)
Sequence: MYVVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAANLHAPVIIAGTPGTFTHAGTENLLALVSAMAKQYHHPLAIHLDHHTKFDDIAQKVRSGVRSVMIDASHLPFAQNISRVKEVVDFCHRFDVSVEAELGQLGGQEDDVQVNEADALYTNPAQAREFAEATGIDSLAVAIGTAHGMYASAPALDFSRLENIRQWVNLPLVLHGASGLSTKDIQQTIKLGICKINVATELKNAFSQALKNYLTEHPEATDPRDYLQSAKSAMRDVVSKVIADCGCEGRA
InterPro domains: - IPR023955: D-tagatose-bisphosphate aldolase, class II, subunit GatY (family) [1-284]
- IPR050246: Class II Fructose-bisphosphate Aldolase (family) [4-278]
- IPR011288: D-tagatose-bisphosphate aldolase, class II, subunit KbaY/GatY (family) [3-284]
- IPR000771: Fructose-bisphosphate aldolase, class-II (family) [1-284]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-284]
Interaction partners: - D-tagatose-1,6-bisphosphate aldolase subunit GatZ
- D-tagatose-1,6-bisphosphate aldolase subunit GatZ
- PTS system galactitol-specific EIIA component
- D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
- ATP-dependent 6-phosphofructokinase isozyme 1
- PTS system galactitol-specific EIIB component
- ATP-dependent 6-phosphofructokinase isozyme 2
- L-threonate dehydrogenase
- 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0043169 (cation binding), GO:0016832 (aldehyde-lyase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0022607 (cellular component assembly), GO:0043933 (protein-containing complex organization), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Glutathione exchanger 1 (P25596)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway
Subcellular location: Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein
Sequence: MSSSVVGASSNKKSGIRQSCEIIERERHSNDDTYSMTSTFFKLKENEIMSAQFDSLKYKILLISTAFVCGFGISLDYTLRSTYTGYATNSYSEHSLLSTVQVINAVVSVGSQVVYSRLSDHFGRLRLFLVATIFYIMGTIIQSQATRLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLKWRMFYQYASYWPYIIIPWISGNIITAANPQKNWSWNIAMWAFIYPLSALPIIFLILYMKYKSSKTAEWRSLKEQARKERTGGLFENLVFLFWKLDIVGILLITVSLGCILVPLTLANETSQKWHNSKIIATLVSGGCLFFIFLYWEAKFAKSPLLPFKLLSDRGIWAPLGVTFFNFFTFFISCDYLYPVLLVSMKESSTSAARIVNLPDFVAATASPFYSLLVAKTRKLKLSVIGGCAAWMVCMGLFYKYRGGSGSHEGVIAASVIMGLSGLLCSNSVIVILQAMTTHSRMAVITGIQYTFSKLGAAIGASVSGAIWTQTMPNQLYKNLGNDTLAEIAYASPYTFISDYPWGSPERDAVVESYRYVQRIIMTVGLACTVPFFAFTMFMRDPELIDKATHEEFTEDGLVVLPDEENIFSQIKALFRHNRSNKKLGC
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [54-573]
- IPR011701: Major facilitator superfamily (family) [67-490]
Interaction partners: - Vacuolar basic amino acid transporter 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015343 (siderophore-iron transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015711 (organic anion transport), GO:0034635 (glutathione transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle)
Protein: Glucosamine 6-phosphate N-acetyltransferase (O93806)
Organism: Candida albicans (Yeast)
Sequence: MMLPQGYTFRKLKLTDYDNQYLETLKVLTTVGEISKEDFTELYNHWSSLPSIYHPYVITNASGIVVATGMLFVEKKLIHECGKVGHIEDISVAKSEQGKKLGYYLVTSLTKVAQENDCYKVILDCSPENVGFYEKCGYKDGGVEMVCRF
InterPro domains: - IPR000182: GNAT domain (domain) [7-149]
- IPR039143: Glucosamine 6-phosphate N-acetyltransferase-like (family) [4-145]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [1-147]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0009225 (nucleotide-sugar metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0006047 (UDP-N-acetylglucosamine metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0006040 (amino sugar metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0046349 (amino sugar biosynthetic process), GO:0009226 (nucleotide-sugar biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Glucosamine 6-phosphate N-acetyltransferase (E3Q1H1)
Organism: Trypanosoma brucei brucei
Function: Involved in the biosynthesis of UDP-N-acetyl-alpha-D- glucosamine. Catalyzes the formation of N-acetyl-D-glucosamine 6- phosphate from acetyl-coenzyme A (acetyl-CoA) and D-glucosamine 6- phosphate
Subcellular location: Glycosome. Note=Predominantly located in glycosome microbodies in the bloodstream form of T.brucei
Sequence: MTDIVDLELRVLEESDLSSHLELLGHLTEAPPLSGVELANIADMRRRAGIVTKVFCHQPTGRIVGSASLMIQPKFTRGGRAVGHIEDVVVDPSYRGAGLGKALIMDLCEISRSKGCYKVILDSSEKSLPFYEKLGFRAHERQMRLDL
InterPro domains: - IPR000182: GNAT domain (domain) [7-147]
- IPR039143: Glucosamine 6-phosphate N-acetyltransferase-like (family) [5-143]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [6-144]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006040 (amino sugar metabolic process), GO:1901071 (glucosamine-containing compound metabolic process), GO:0006044 (N-acetylglucosamine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0020015 (glycosome)
Protein: O-antigen biosynthesis glycosyltransferase WclY (B8QSK0)
Organism: Escherichia coli
Function: Involved in the assembly of the O-repeating unit during O- antigen biosynthesis. N- acetylglucosamine transferase accountable for the alpha-D-GlcNAc-1,4- beta-D-Gal linkage within the O-antigen
Subcellular location: Membrane; Single-pass membrane protein
Sequence: MKIAYVVSSKKKCGPNIVILNIVKELANKHEMEIFFLDESDDDVFECVNVKSTQIKKASDLKEHLKRFDIIHSSGIRPDALVVLCKVIYRVKCKIITTIHNYVFQDLYYSYGLVKSLIWGLLWCSIWLFFDKLVILSKNADNYYWFLPSAKKNIIYNGIDDNDCLQNKKCNYRKEFNIPDDGILAGSCANLTKCKGIDLVIQTLTKEHKIYYIVAGDGIEKHNLINLVKARKLHERVYFIDFLDEPESFMSQLDVFLMPSRSEGFGLTVLESTKLGIPVITSNIPIFMELFDQMCLTFDIKNPSTLIDVITYAKKNRLHLSQKFHAIFQDRFTSSKMATKYENVYNNLFREVL
InterPro domains: - IPR028098: Glycosyltransferase subfamily 4-like, N-terminal domain (domain) [14-161]
- IPR001296: Glycosyl transferase, family 1 (domain) [171-319]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0009311 (oligosaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0008653 (lipopolysaccharide metabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0009103 (lipopolysaccharide biosynthetic process), GO:0009312 (oligosaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0046401 (lipopolysaccharide core region metabolic process), GO:0009244 (lipopolysaccharide core region biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)