Protein: phospholipase A2 (EC 3.1.1.4) (A0A590UK51)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKAAETVRLSDTSQSNSPIACGWGAWDPEWEASPKIIQQIGSRACSEANKRGSGRAQRLTPVIPALWEAEGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP
InterPro domains: - IPR016035: Acyl transferase/acyl hydrolase/lysophospholipase (homologous_superfamily) [427-808]
- IPR047148: 85/88 kDa calcium-independent phospholipase A2 (family) [1-627]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [138-399]
- IPR002110: Ankyrin repeat (repeat) [151-381]
- IPR002641: Patatin-like phospholipase domain (domain) [427-611]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042802 (identical protein binding), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0016790 (thiolester hydrolase activity), GO:0004622 (lysophospholipase activity), GO:0016289 (CoA hydrolase activity), GO:0004623 (phospholipase A2 activity), GO:0004620 (phospholipase activity), GO:0047499 (calcium-independent phospholipase A2 activity), GO:0047617 (acyl-CoA hydrolase activity), GO:0016290 (palmitoyl-CoA hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006952 (defense response), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0098542 (defense response to other organism), GO:0006793 (phosphorus metabolic process), GO:0050776 (regulation of immune response), GO:0002433 (immune response-regulating cell surface receptor signaling pathway involved in phagocytosis), GO:0006629 (lipid metabolic process), GO:0002757 (immune response-activating signaling pathway), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0006959 (humoral immune response), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:1901575 (organic substance catabolic process), GO:0019730 (antimicrobial humoral response), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:1901565 (organonitrogen compound catabolic process), GO:0006644 (phospholipid metabolic process), GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis), GO:0006796 (phosphate-containing compound metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0045017 (glycerolipid biosynthetic process), GO:0046470 (phosphatidylcholine metabolic process), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0046486 (glycerolipid metabolic process), GO:0042742 (defense response to bacterium), GO:0090407 (organophosphate biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:0046434 (organophosphate catabolic process), GO:0008610 (lipid biosynthetic process), GO:0038093 (Fc receptor signaling pathway), GO:0006909 (phagocytosis), GO:0002431 (Fc receptor mediated stimulatory signaling pathway), GO:0046474 (glycerophospholipid biosynthetic process), GO:0019731 (antibacterial humoral response), GO:0046503 (glycerolipid catabolic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0009395 (phospholipid catabolic process), GO:0034638 (phosphatidylcholine catabolic process), GO:0006655 (phosphatidylglycerol biosynthetic process), GO:0046475 (glycerophospholipid catabolic process), GO:0046471 (phosphatidylglycerol metabolic process), GO:0038094 (Fc-gamma receptor signaling pathway), GO:0032048 (cardiolipin metabolic process), GO:0032049 (cardiolipin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)