Protein: Inositol polyphosphate 1-phosphatase (IPP) (IPPase) (EC 3.1.3.57) (P49441)
Organism: Homo sapiens (Human)
Function: Mg(2+)-dependent phosphatase that catalyzes the hydrolysis of the 1-position phosphate from inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate and participates in inositol phosphate metabolism.
Sequence: MSDILRELLCVSEKAANIARACRQQEALFQLLIEEKKEGEKNKKFAVDFKTLADVLVQEVIKQNMENKFPGLEKNIFGEESNEFTNDWGEKITLRLCSTEEETAELLSKVLNGNKVASEALARVVHQDVAFTDPTLDSTEINVPQDILGIWVDPIDSTYQYIKGSADIKSNQGIFPCGLQCVTILIGVYDIQTGVPLMGVINQPFVSRDPNTLRWKGQCYWGLSYMGTNMHSLQLTISRRNGSETHTGNTGSEAAFSPSFSAVISTSEKETIKAALSRVCGDRIFGAAGAGYKSLCVVQGLVDIYIFSEDTTFKWDSCAAHAILRAMGGGIVDLKECLERNPETGLDLPQLVYHVENEGAAGVDRWANKGGLIAYRSRKRLETFLSLLVQNLAPAETHT
InterPro domains: - IPR050725: CysQ/Inositol Monophosphatase (family) [3-380]
- IPR020550: Inositol monophosphatase, conserved site (conserved_site) [315-329]
- IPR020583: Inositol monophosphatase, metal-binding site (binding_site) [151-163]
- IPR000760: Inositol monophosphatase-like (family) [82-377]
- IPR044897: Inositol polyphosphate 1-phosphatase, domain 1 (homologous_superfamily) [81-127]
Interaction partners: - Inositol monophosphatase 2
- Inositol monophosphatase 1
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
- Inositol-tetrakisphosphate 1-kinase
- Inositol polyphosphate-4-phosphatase type I A
- Inositol polyphosphate-5-phosphatase A
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- Inositol polyphosphate 4-phosphatase type II
- Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0042803 (protein homodimerization activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding), GO:0016791 (phosphatase activity), GO:0008252 (nucleotidase activity), GO:0052745 (inositol phosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0000096 (sulfur amino acid metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0000097 (sulfur amino acid biosynthetic process), GO:0009069 (serine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0006555 (methionine metabolic process), GO:0009070 (serine family amino acid biosynthetic process), GO:0009086 (methionine biosynthetic process), GO:0009067 (aspartate family amino acid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)