Protein: Polynucleotide kinase 3'-phosphatase (Q6AXV0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MSELGSRGRLWLQSPTGGPPPIFLPSDGQALVLGRGPLTQVMDRKCSRNQVELIADPETRTVAVKQLGVNPSTVGVQELKPGVSGSLSVGDVLYLVNGLYPLTLRWEEISTPGSPPDTPPGNPVDPEEGKDTEPQKKRMRKSSPGWESFKQLLVFTASGVKPRGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVILTNQMGIGRGKLPAEVFKAKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEKGNEGIPISIGDSVFVGDAAGRPANWAPGKKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSFLLSPNPEVVVAVGFPGAGKSTFIQKHLVSAGYVHVNRDTLGSWQRCVNSCQAALRQGKQVVIDNTNPDIQSRARYIQCAKDAGVPCRCFSFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEGFLEILQVPFRLQEHLDPALQRLYCQFSEG
InterPro domains: - IPR013954: Polynucleotide kinase 3 phosphatase (family) [165-327]
- IPR041388: PNK, FHA domain (domain) [11-80]
- IPR036412: HAD-like superfamily (homologous_superfamily) [150-337]
- IPR006550: Bifunctional polynucleotide phosphatase/kinase PNKP (family) [3-522]
- IPR023214: HAD superfamily (homologous_superfamily) [143-337]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [338-522]
- IPR006551: Polynucleotide 3'-phosphatase (domain) [152-327]
- IPR006549: HAD-superfamily hydrolase,subfamily IIIA (domain) [165-309]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [5-110]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016301 (kinase activity), GO:0003677 (DNA binding), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0004713 (protein tyrosine kinase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0033554 (cellular response to stress), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006974 (cellular response to DNA damage stimulus), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination), GO:0070534 (protein K63-linked ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)