wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Alpha-amylase (A0A8M2B5V6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MKLLVVAALVGLCLSQHNTNFKHNRTSIVHLFEWRWADIAKECERYLAPNGYGGVQISPPSESIVLTKPWHPWWQRYQPISYNLCSRSGTEEELKDMIARCNNVGVNIYADAVINHMCGASGGEGTHSSCGTYFNAKNEDFPSVPYSSWDFNDNKCKTANEDIENYSDIFQVRDCRLVSLLDLALEKDYVRGKVAEYMNKLIDIGVAGFRVDACKHMWPGDLSNVYSRLKTLNTTWFSPGTKPFIYQEVIDLGGEPIKASEYVSLGRVTEFKYSAKLGTVIRKWEKEKLCYLKNWGEGWGFMPSHKALVFVDNHDNQRGHGAGGASVLTFWDSRLYKIATGLMLAHPYGVTAVMSSYRWDRHFVNGKDQNDWMGPPSNADGSTKSVPINPDSTCGDNWICEHRWRQIRNMVIFRNVVNGQPLSNWWDNNNNQIAFSRGSKGFIVINNDDWDLNVTLKTGLPSGTYCDIISGDKSGNSCTGKQVTVDSDGQATFSICHTEEDPFMAIHADSKL
InterPro domains: - IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [17-415]
- IPR006048: Alpha-amylase/branching enzyme, C-terminal all beta (domain) [426-508]
- IPR031319: Alpha-amylase, C-terminal domain (domain) [423-511]
- IPR006047: Glycosyl hydrolase family 13, catalytic domain (domain) [26-414]
- IPR013780: Glycosyl hydrolase, all-beta (homologous_superfamily) [420-512]
- IPR006046: Alpha amylase (family) [73-317]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0016160 (amylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0043627 (response to estrogen), GO:0071310 (cellular response to organic substance), GO:0032870 (cellular response to hormone stimulus), GO:0071391 (cellular response to estrogen stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Tissue factor (C7S6G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MDSNMRQITLHTLVLALVSFFTTSCASDVFPKAKNVSWSSVNFKSMLTWSPKPTNYSYTVEFSELSQDRERTPYCIRTMDTECDLTAVLKNLKAYYSADVLSEPMRGVSSDLVEFPHVSSGKFSPYHDTDIGRPEFKIEVSSDKRMTKLHVTDVPTALFDDQKKRLNIRDVFGDELQYKVIYRKAKSTGKKEMLSKKSIIEMPDLDRGVGYCFNVQAYLPSRAANKQFGELSSVHCSTEENTTVFEEYGTGVITGVIVFILSAIIVIVLVIVMCCRRRRRAENEGKEGLALNGL
InterPro domains: - IPR001187: Tissue factor (family) [33-266]
- IPR015373: Interferon/interleukin receptor domain (domain) [129-238]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [31-237]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [26-238]
- IPR003961: Fibronectin type III (domain) [13-109]
- IPR050650: Type II Cytokine and Tissue Factor Receptors (family) [15-275]
Interaction partners: - Prothrombin
- Coagulation factor IX
- Antithrombin-III
- TLC domain-containing 4a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009611 (response to wounding), GO:0042060 (wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ribosomal protein L18 (Q6DGL0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm, cytosol
Sequence: MGVDIRHNKDRKVHRKEPKSQDIYLRLLVKLYRFLSRRSDAPFNKVILRRLFMSKTNRPPLALSRLIRKMKLPGRENLTAVVVGTITDDVRIQNIPKLKVCALKVTDRARSRILKAGGQIMTFDQLALTSPRGRGTVLLSGPRKGRQVYRHFGKAPGTPHSHTKPYVRSKGRKFERARGRRH
InterPro domains: - IPR036227: Large ribosomal subunit protein uL15/eL18 superfamily (homologous_superfamily) [19-139]
- IPR000039: Large ribosomal subunit protein eL18 (family) [1-181]
- IPR021132: Large ribosomal subunit protein eL18, conserved site (conserved_site) [49-66]
- IPR021131: Large ribosomal subunit protein uL15/eL18 (domain) [2-182]
Interaction partners: - Small ribosomal subunit protein uS15
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL6
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein uL29
- Small ribosomal subunit protein uS14
- 60S ribosomal protein L37a
- 40S ribosomal protein S24
- Large ribosomal subunit protein uL10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Hexosyltransferase (A0A8M1NHC5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein
Sequence: MPRRGLPLQGRARWLLLGVFLLVILLLFAYLLECTPPADVSQVLPGLAGDPYGKEYYQALLQEQEERHLSRAASLKRQIAQLKQELQEMSEKLRVLQEKKEGPGPQSLNDGRDQEPGDLLEYLHSQIDKAEVNTGARLPSEYALVPFESFTTTKVYQLEMGLTRHPEEKPVRKDRRDELVEVIEAGLDIINNPEEDDGQEDNIPMQRQTFTESQFFEGLYRTERDKGTLYELYFAKENSHEYRHVTLFRPFGPLMKVRSTSVDTASAIINIIVPLSGRTEAFVQFLHNFREVCIQQDKRVHLTVVYFGQAGLQDVKESLKKMASEESFSNYTLIPVDEEFSRGRGLDIGAHAWEKGGDVLMFFCDVDIYFTLEFLSTCRLNTAPGKRVFYPVVFSLYNPAIVYGNLEFPPPIESQLIHKKDAGFWRDFGFGMTCQYRSDFLNIGGFDLEVKGWGVEDVHLYRKYLRSDPIVIRTPVSGLFHLWHEKLCADELTPEQYRMCIQSKAMNEASHSHLGMLVFREEIETHLRKQAYKTQSRPAE
InterPro domains: - IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [259-535]
- IPR008428: Chondroitin N-acetylgalactosaminyltransferase (family) [72-514]
- IPR051227: Chondroitin sulfate glycosyltransferase (family) [169-515]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0008376 (acetylgalactosaminyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0009100 (glycoprotein metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0015012 (heparan sulfate proteoglycan biosynthetic process), GO:0006029 (proteoglycan metabolic process), GO:0009101 (glycoprotein biosynthetic process), GO:0050654 (chondroitin sulfate proteoglycan metabolic process), GO:0030166 (proteoglycan biosynthetic process), GO:0050650 (chondroitin sulfate proteoglycan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Vigilin (A0A8M2BDG6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol
Subcellular location: Cytoplasm. Nucleus
Sequence: MSSVAVLTQESFNEHRSGLLPEQVKAAAGGDPSSVEDDDSLPTYKDAFPPLPEKPLPEGVQETENAWTTKIKPLKSSIITQVFHVPLEERKYKDMNQFGEGDQAKVCLDIMHKTGAHLELSMAKDQGLSIMVSGKYDAVMKARKEIVSRLQTQASATVAIPKEHHRFVIGKSGEKLQELELKTATKIQIPRPDDPSNQIKISGTKEGLEKAKHEILLISAEQDKRAVERMNIDKVFHPFITGAHGKLVGDLMQETGARINVPPPSVNKTEIVITGEKEQVALAMVKIKKLYEEKKKNATTIAVEVKKSQHKYVIGPKGNTLQEILERTGVSVEIPPLDSSSETVILRGEPARLGQALTEVYAKANSYTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTKDVQIVQGQIEVIVTDLVSRMDYTEISVDPKFHRHLIGKGGANINRIKELHKVSVRIPPDNEKSNLIRIEGDPQGVQEAKKELLELASRMENERTKDMIIEQRFHRAIIGQKGEKIKEIRDKFPEVIINFPDPAQKSDIVQLRGPRTEVEKCSKFMQKMVAEMVENSFSVSVPIFKQFHKNIIGKGGANIKKIREETNTKIDLPAENSNSEMIVITGKKANCEAAKNRILAIQKELANITEVEVSIPSKLHNSLIGSKGRFVRSIMEECGGVHIHFPTEGSGIDAVTIRGPAEEVEKAKKQLLSLAEEKQTKSHTVELRAKPEYHKFLIGKGGGNIRKVRDSTGARIIFPTAEDKDHELITVIGTEEAVAEAQKELEALIKSLDNIVEDFMIVDPKHHRFFVARRGQVLRDIADEYGGVIVSFPRTAAQSDKVTLKGAKDCVEAAKKRMLEMIEDLDAQVTMECVIPQKFHRSIMGPKGSRIQQITKDHNVQIKFPDREEQQQADASVQENGEANGEVKEPVDPTAPKKCDVIVLSGRKERCEAAVEALKALVPVTIAVEVPFELHRYIIGQKGSGIRKMMDEFEVNIQVPAHELQSDIISITGLASHLDRAKEGLLERVKELQAEQEDRALRSFKLTITVEPKYHPKIIGRKGAIISHIRHDHEVNIQFPEKNDENQDQITITGYEQNAIAARDAIQAIVDELEEMISEDITLDSRVHARIIGARGKGIRKIMDEFKVDVRFPQSGAADPNLVTVTGRPEHVDEAIDHLLNLEEEYMADVVENEAKMAYMKPSGSSASSMEEPRGPSKGFVVREAPWATGNEKAPDMSSSEEFPSFGAPVAAAARASPWGPKRF
InterPro domains: - IPR057778: Vigilin, N-terminal KH domain (domain) [88-154]
- IPR004087: K Homology domain (domain) [152-1192]
- IPR004088: K Homology domain, type 1 (domain) [156-1188]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [147-1200]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0043627 (response to estrogen), GO:0071310 (cellular response to organic substance), GO:0032870 (cellular response to hormone stimulus), GO:0071391 (cellular response to estrogen stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Pannexin (F1QSR7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Structural component of the gap junctions and the hemichannels
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi- pass membrane protein
Sequence: MAIARVATEYVFSDFLLKEQSDSKYKGVRLELATDKLVSFIAVGLPLLLISLAFAQEVSVGTQITCFPPTNFTMRQAAYADSFCWAAVEHHPSENETYSAPLHLHKFFPYILLLLAILMYIPALFWRFTAAPSLSSDLSFIMEELDRCYNRAIRLAKSITTKQDKDIAEDPHSGLELTEACFKYPLVEQYLKTKRSSWALAAKYLLCRVLTFLTLLLGCFYLTYYIFWVSPSDQFSCHLRRGILVNQSEVPDVVQCKLVAVGVFRLLSCMNLVVYLLLVPAVVYAGLQPARQHQRGQFLRPYHLLPAFGHVLDLQPATRRYDDLSIYLLFLEENLSELKSYKCLQVLELLSEGGEAAFDTMCLLRTLGQVKTDMVDKRQAQTVNGNPEIVISEIKDVSVLLDDGVQADKSCSCVKDVRQRVV
InterPro domains: - IPR039099: Pannexin (family) [1-385]
- IPR000990: Innexin (family) [27-388]
Interaction partners: - Caspase a
- Pannexin
- Ectonucleoside triphosphate diphosphohydrolase 8
- Gap junction protein
- Gap junction alpha-1 protein
- Caspase b,-like
- Calcium homeostasis modulator 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015267 (channel activity), GO:0022829 (wide pore channel activity), GO:0022836 (gated channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0001503 (ossification), GO:0048856 (anatomical structure development), GO:1904888 (cranial skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Nociceptin receptor (A0A0R4IZH2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle
Sequence: MEFPNDSIGFTDPRHFHLYNESLFQNNFSTFNESDSFFPKGFKITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLALADALVLATLPFQGTDVFLGFWPFGNALCKVVVSIDYYNMFTSVFTLTVMSMDRYVAVCHPVKALDMRTPHKAKVVNICVWVLASAIGVPAMVLGDVEQDNGIECILVLPDPRSYWDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLRSVRILSGSKEKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQSLGFNLASVQTVVFMHFCIALGYVNSSLNPVLYAFLDENFKRCFREFCHPSRFGIDAQQSGRMRHITREVAFNCKTTDGNSNPA
InterPro domains: - IPR001420: X opioid receptor (family) [99-359]
- IPR001418: Opioid receptor (family) [70-321]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [45-325]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-310]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0042923 (neuropeptide binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate-binding) (A0A8M2B4U7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MSQNKGYSRFDNAVDGDDPSPPPPPGFVMPPAYEAAVQYGHADATVPVAVPVGPPYAFESPAYGQGVSGYPQQPYPVAAPYSTDPYSQPFPNVVAMGEPGQSNDPPEYDSDQFTSSGLDNKEIRRVFIRKVFSVLSLQLAITTAFVAIFTFEPHVKLFVMQNSWTYWVGYLVFLVPYFVILCCGEFRRKHPWNLICLSVLTLAMSYMVGVISSFYDTDIVIMAIGITVVVCFTVIIFSMQTKYDFTSCYGVLFVCGIVLFVFGILCIIFYSKIMDLIYSTLGALLFTCFLAVDTQLLLGNKNLSLSPEEYIFASLNLYLDIIQIFLFILRILGRSRS
InterPro domains: - IPR006214: Bax inhibitor 1-related (family) [70-334]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0008219 (cell death), GO:0090559 (regulation of membrane permeability), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0012501 (programmed cell death), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006839 (mitochondrial transport), GO:0046902 (regulation of mitochondrial membrane permeability), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0006915 (apoptotic process), GO:0007005 (mitochondrion organization), GO:0007006 (mitochondrial membrane organization), GO:0008637 (apoptotic mitochondrial changes), GO:1902108 (regulation of mitochondrial membrane permeability involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Unconventional myosin-Ic (A0A8M3APY8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, ruffle membrane. Cell projection, stereocilium membrane. Cytoplasm, cell cortex. Cytoplasmic vesicle
Sequence: MMESALTARDRVGVQDFVLLENHTSEVAFIENLRKRFKENLIYTYIGSVLVSVNPYKDLEIYTKQHMERYRGVNFYEVSPHIYAVADNAYRSMRTERRDQCILISGESGAGKTEASKKVLQYYAVTCPASDHVQTVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFKGAPVGGHILNYLLEKSRVVHQSNGERNFHIFYQLIEGGEDDLLRRLGLERNAQQYQYLVKGNCPKVSSINDRNDWKTVRKALSVIGFTDDEVEELLNIIASVLHLGNVQYGGEDSGSAYITTDTQIKYLARLLGVDGTVLKEALTHKKIIAKGEELMSPLNQEQAASARDALSKAIYGRTFSWLVNKINDSLAFKDESFSSKNASVIGLLDIYGFEVFQNNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGITWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGDASDITFLEKLENTVGGHAHFLTHKLADGKTRKVMGREEFRLIHYAGEVNYNVKGFLDKNNDLLFRNLKQVMCMSENKILNQCFDREELSDKKRPETAATQFKNSLAKLMEILMSKEPSYVRCIKPNDAKQAGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRRYETFLQRYKSLCPDTWPNWDGRQVDGVSTLVKHLGYKPEEYKLGRTKIFIRFPKTLFATEDALEVRKHSLATQLQSSWKGYSQKTKYQKMRHSAVWIQAWWRGILARRAAKRRREAADTIRRFIKGFIYRHQPRCPENEYFLDYVRYSFLMNLHRCQPKTVLDKSWPTPPPALVEASQHLRKLCMQNMVRKYCKNINPEWKHQMEQKVVASKIFKDKKDNYPQSVPKLFVNTRLNGEDINPKVLQALGNEKMKYAVPVIKYDRKGYKARNRQLLLMSDSAVIVEEGKLKQRIDYNSLKGISVSSLSDGMFVFHVASEDNKQKGDVVLQNEHVIETLTKVAICADKMDDININQGSIKFDVAQGKEGIIDFTAGSELLIVKAKNGHLSVTAPRLNSR
InterPro domains: - IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [13-626]
- IPR001609: Myosin head, motor domain-like (domain) [6-697]
- IPR036072: Class I myosin, motor domain (domain) [28-683]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [10-750]
- IPR000048: IQ motif, EF-hand binding site (binding_site) [698-766]
- IPR010926: Class I myosin tail homology domain (domain) [850-1024]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0008289 (lipid binding), GO:0000146 (microfilament motor activity), GO:0044877 (protein-containing complex binding), GO:0043167 (ion binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0043325 (phosphatidylinositol-3,4-bisphosphate binding), GO:0035091 (phosphatidylinositol binding), GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0072006 (nephron development), GO:0048731 (system development), GO:0032835 (glomerulus development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)