Protein: E3 ubiquitin-protein ligase (EC 2.3.2.26) (A0A590UJW8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [13-155]
- IPR000569: HECT domain (domain) [475-830]
- IPR001202: WW domain (domain) [285-438]
- IPR024928: E3 ubiquitin-protein ligase, SMURF1 type (family) [6-830]
- IPR000008: C2 domain (domain) [1-115]
- IPR050409: E3 ubiquitin-protein ligase (family) [129-828]
- IPR035983: HECT, E3 ligase catalytic domain (homologous_superfamily) [457-824]
- IPR036020: WW domain superfamily (homologous_superfamily) [280-437]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0043021 (ribonucleoprotein complex binding), GO:0005102 (signaling receptor binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0019899 (enzyme binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0044389 (ubiquitin-like protein ligase binding), GO:0005126 (cytokine receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity), GO:0042379 (chemokine receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009056 (catabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0032103 (positive regulation of response to external stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0046718 (viral entry into host cell), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0030522 (intracellular receptor signaling pathway), GO:0001817 (regulation of cytokine production), GO:0043170 (macromolecule metabolic process), GO:0002218 (activation of innate immune response), GO:0031348 (negative regulation of defense response), GO:0009894 (regulation of catabolic process), GO:0051701 (biological process involved in interaction with host), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0001818 (negative regulation of cytokine production), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0031349 (positive regulation of defense response), GO:0002832 (negative regulation of response to biotic stimulus), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:0050687 (negative regulation of defense response to virus), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0030163 (protein catabolic process), GO:0044000 (movement in host), GO:2000736 (regulation of stem cell differentiation), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0043412 (macromolecule modification), GO:0044265 (cellular macromolecule catabolic process), GO:0050688 (regulation of defense response to virus), GO:0032480 (negative regulation of type I interferon production), GO:0002753 (cytosolic pattern recognition receptor signaling pathway), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0010629 (negative regulation of gene expression), GO:0042981 (regulation of apoptotic process), GO:0002221 (pattern recognition receptor signaling pathway), GO:0043066 (negative regulation of apoptotic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:1902036 (regulation of hematopoietic stem cell differentiation), GO:0044409 (entry into host), GO:0010498 (proteasomal protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0032446 (protein modification by small protein conjugation), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0016567 (protein ubiquitination), GO:0051865 (protein autoubiquitination), GO:0006513 (protein monoubiquitination), GO:0000209 (protein polyubiquitination), GO:0070936 (protein K48-linked ubiquitination), GO:0070534 (protein K63-linked ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043233 (organelle lumen), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0065010 (extracellular membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)