Protein: Protein O-mannosyl-transferase Tmtc2 (Q9V3X5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Transfers mannosyl residues to the hydroxyl group of serine or threonine residues
Subcellular location: Membrane; Multi-pass membrane protein. Endoplasmic reticulum
Sequence: MPSLEPWLWGDSCSWLGMLAMLRLRLHKSNMDFTCLFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAVAGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQWLALGATLILAAAGLLCKETAITALLVCALFDVMRGLSGQVDKQRLRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINPPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGDAITLGNLAKLGVTNV
InterPro domains: - IPR013618: Protein O-mannosyl-transferase TMTC, DUF1736 (domain) [272-343]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [567-937]
- IPR052384: O-mannosyl-transferase TMTC (family) [28-935]
- IPR019734: Tetratricopeptide repeat (repeat) [602-923]
Interaction partners: - FXNA-like protease
- FXNA-like protease
- Uncharacterized protein
- LD33689p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0008219 (cell death), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0012501 (programmed cell death), GO:0035556 (intracellular signal transduction), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0097190 (apoptotic signaling pathway), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0072331 (signal transduction by p53 class mediator), GO:0010212 (response to ionizing radiation), GO:0006974 (cellular response to DNA damage stimulus), GO:0006915 (apoptotic process), GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage), GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator), GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)