Protein: HD protein homolog (Q76P24)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May play a role in microtubule-mediated transport or vesicle function
Subcellular location: Cytoplasm. Nucleus
Sequence: MDLIRGLDILSASPIDTEDQNLRKEKIEACRTISEQICAPSLRNTADFPRFLSIAISLLLRAHGDKDLNVYSVAEESLNRTIKILVYSYHERILFELFKVLKGKPHQHNNEKRLSTNLTDHLSQNSVTPSVPTTPNYQQSPSTQSPSHSTSNSSNNLYNNFSSNSNSNSNSNSNSSSNNNSGNTTPGNNTNNSNGNANSIFNTANQILSKPFPLKSQRIALIKFGEICSFIRPSKCRKYILSLVPPINSLLSIIEDESLQESISISMENISKILIPYLKENEVHQLIDLFSRNLQQPSAAVRRAASLSITSICRYHPRPLFEFTIEFLYNFTFPNSPPISSITSASCIPASSNTNTLQNSKILGVLFSYLQLIKLAEELSSNDIKILDGFSLKIQFFVHFILKYIQVPIDGEPYDHNIVGLSLELLQQLLVTFGPYEYSWPKPLVREVIAQLRHLCFNQQSSIRVSLKAVVLNCLAQSVKFFPKLFNDEFFKHQPSTIDSNTVTSAEDHICRDYLLNISPSDLNFKLFTPITQQQQQQQQQQQQQQQQQQQHNLTSSTMSGINSTTGVSNHTFSLEPKEEFLYYLNDSDPLLRGGTALMIGCLIRGYLETDHITSNQIYPTNIALLEDNLSIPTLLIFLLRALMDSSSITAKLACTGISECLPILSQSKFSDWALVTLRHLLCVSSSTYWLVKLEILETLSMIDYIVIEYLEQNIQQKSNVMNVVINGPNLSISTSSIKINENNNNSNNSNNNKNNSETGGAVAIPIQSKVLDFLIEQLSDNDFRVRNSAGKSLVRVIPKLVFTAPLERHSMKGISSKVRETFDVQDYENTVLRKRKIFANLSHVIGLLVNQLSNPHPDDKIRGCYGALNLICKTYSFPPDTPEQCRTLSSVLANPMLSFVGDILPLALDRVGLTWVATDFDVHIDIIEILGYLSRGAENVLGTYCHNVLRHIVRIINIATNIIQFRPTPPLKEVKSNPSGIHVNSPLLKAPTHLGSFTHSIHYIKLYSKLLTARINSITIFGIDRFSQLRQACFETLSVMLKCAGKTILPYTEEIIGYLTTHFEQEPVSVIKCINELFLVTMKPTPIVSISSLSQKSRDLNIGGGFISTGGGGGGGSGGINSSSSSLKQYEPRSIESHSSSSNSHDEMFLNSRSVFSSLLTFGTPNLKQHYDFINEVPSSHNINYSYSNSEINRIISNEDRKLNFKLFEPLIIGSMIEYQTTHSHELKIAILLMLSKLSKFGLDLSLFDKENHFPTYFIEELKETHCLLSKPNQVLSYSYDLLGSMFIYRKLFPDSSVSIDDIKKLFFQPPPQQQQQTNQNKSQSLNSTPNISSNNNNNNNNNNNNNNNNNNNNNNNSNSSQSLNNSTVIGNNSSHPYSYTIPTIIENCHSFVRYLYDPNDKYPDTDFRERFLSFLLSNLQYSQTIDILILIVTIVQPNSTLHQKFSQQISHQLFTNLSLGDSPFFIINSIEEVERLYVLIDKLHSSSLSAARWADALLSVSPQFVNKSTSSSSSSSSTATSPSSSSSSTTTTTTTSTNTTTTTPSDPLIRKRILLLRESILEAYELRWLPPLLVLLRTGCKLPEEARISAARQSRFLSNHDNKHQPGPSAAIISTLLLKLIRNAVSVFSLYKPKNVLFTQLINHLLYYSSIFFNKNLVPHISAQSLSNSPNFGATNTTTGSGSVSPLSSSSSSTITVTTMAMGSSLMKQPSSSLLLSPTVGGSSSTINLFMDSLKGILALDNGTIIQEITTSLLSYGGTSTSIHAVKLLLLLGRLPNQQVIEGADLVWKQYALSNNWQSCGCEHFLTHHIIFLLYCQSIVVLKSQNIELSETFLDKIVLLINESTVKKLIEFLVKGGSNSDQNQYIEIFTQHLVKIFSRVSNSLDLRKKQKLLRLLSYLPANRETLELLIVNFLQTDDISLQVSGERILNLNINNLIETYGPQNSLEIIQELYQIFMSNFVKSTTNQSVQSLFLKLIKNLSPSSAYQGITPTHNNVIEKLKEKELTNNNNNNNNNIIEKEEEEKEKEKEKVKEEEEGNNIEKLIQLQIETIKKNNQISDLKTVPWDYFVELIKSRYYSNNLNQHSFNNISILSQIDKDATISLLESKSLDGTLLPAFISSVYSLEFQDEIQAYLLKKVDTLLGLAGEIGTDPLKGGPPFLSDSVWDELRETTRCLSNFINKFGLGELCESKLLKVSTWAFIESFRRWRAEIINPYDFKLVLELSRSIILKSTASILTITDDSEWCSLLLCLYKLYCLVIRPHFGYISGQRELEENFSQDPTQISLTQSNEMIKFLVSLLTNVKSYTPMPGSHIGQLIFDSFIRAIIPLSTKAFDFIYPTVSTSSEDEFGGGIIPNCPIFSSNVSPEQNIKALVSFIHFVDIDDEFKFKQIWEMLEPIFVSPLGDAEMGSDEITEECKCLSLSGMATMIIKVCFEVTGVNSQVNLLETSTIPKSTYNHIPREKDLMFLNTPTGKKLNHLLSTIYGDMPQSELPLGGAIESVSSSSSMFGESSGNHQNMSSSSLSAYHFNIERSFSSNQFGSDQISLSDLRLFKTPYFIGVNFTPIIQKLLESFESFLVNPMCPPMLKKDILKSTVLLSDLFNREQVIWMFKTFTTIYAQDEIDDFLLKQHLILGICKGIAILQTPPNVGDSNAHSVGIFEMLKSALDHQNISLQVSALDGILYLLEGKVNKYIQGSLLQFLFRWIPTRLSSVPFPPVSLTLRVLATMFLMIEQYSREAEETLFTKRAVTTCIQLGQQQSTPVPIVYGVFRGLDRLLVSFSLSHSQRELISHFSLKSLPSENPIRSLLALGLMVTCIYTGDETGINSPSFTKSSISSIGSGGVNSLTAFEGSFSSSSIESPLNSALDSVMSSFIMDDNYSGSGGNSLINGGGGGDPLSSLDRQKFSRVNNMEKVKMLFDKIRLVSHFSYESHVLSEVLPVVIVDLFPSVDQVLSFILGEFLKQSKTNSKLMCQIISKVFDFLVENDTSENTNQHLINYWIIICLQNFFQIQNPTHCLWALTYLFLTSSPKRSFKLLESEFASKIQTNEKLFIIIASEFYFNKELSKENKQLFKDSFSKLKIEPYISLLKVINTTQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [196-1289]
- IPR011989: Armadillo-like helical (homologous_superfamily) [193-1085]
- IPR048413: Huntingtin, C-terminal HEAT repeats (repeat) [2582-3030]
- IPR028426: Huntingtin family (family) [433-3091]
- IPR024613: Huntingtin, N-terminal, HEAT repeats 2 (repeat) [585-1078]
- IPR048411: Huntingtin, N-terminal, HEAT repeats 1 (repeat) [215-316]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0007155 (cell adhesion), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0099120 (socially cooperative development), GO:0065009 (regulation of molecular function), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032506 (cytokinetic process), GO:0050801 (monoatomic ion homeostasis), GO:0050790 (regulation of catalytic activity), GO:0000910 (cytokinesis), GO:0060176 (regulation of aggregation involved in sorocarp development), GO:1903047 (mitotic cell cycle process), GO:0031156 (regulation of sorocarp development), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0098609 (cell-cell adhesion), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0006970 (response to osmotic stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0032970 (regulation of actin filament-based process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0044087 (regulation of cellular component biogenesis), GO:0030587 (sorocarp development), GO:0010035 (response to inorganic substance), GO:0031154 (culmination involved in sorocarp development), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0043603 (amide metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031150 (sorocarp stalk development), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0044260 (cellular macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0009059 (macromolecule biosynthetic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0006518 (peptide metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0031149 (sorocarp stalk cell differentiation), GO:0032956 (regulation of actin cytoskeleton organization), GO:0043604 (amide biosynthetic process), GO:0010628 (positive regulation of gene expression), GO:0032104 (regulation of response to extracellular stimulus), GO:0010468 (regulation of gene expression), GO:1901566 (organonitrogen compound biosynthetic process), GO:1902903 (regulation of supramolecular fiber organization), GO:0006412 (translation), GO:0051592 (response to calcium ion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0055080 (monoatomic cation homeostasis), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:1902410 (mitotic cytokinetic process), GO:0035864 (response to potassium ion), GO:0033043 (regulation of organelle organization), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0043327 (chemotaxis to cAMP), GO:0034645 (cellular macromolecule biosynthetic process), GO:0008104 (protein localization), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0010467 (gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0000281 (mitotic cytokinesis), GO:0006971 (hypotonic response), GO:0061024 (membrane organization), GO:0051493 (regulation of cytoskeleton organization), GO:0043043 (peptide biosynthetic process), GO:0031399 (regulation of protein modification process), GO:0010921 (regulation of phosphatase activity), GO:0043519 (regulation of myosin II filament organization), GO:0019220 (regulation of phosphate metabolic process), GO:0016339 (calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules), GO:0032107 (regulation of response to nutrient levels), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0061952 (midbody abscission), GO:0043666 (regulation of phosphoprotein phosphatase activity), GO:0140582 (adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway), GO:0035303 (regulation of dephosphorylation), GO:0035304 (regulation of protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)