Protein: Tryptophan decarboxylase 2 (EC 4.1.1.-) (Q7XHL3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in serotonin biosynthesis. Catalyzes the decarboxylation of L-tryptophan to tryptamine, which is converted to serotonin by tryptamine 5-hydroxylase. May play a minor role in serotonin biosynthetis during senescence. Accumulation of serotonin attenuates leaf senescence.
Sequence: MEGVGGGGGGEEWLRPMDAEQLRECGHRMVDFVADYYKSIEAFPVLSQVQPGYLKEVLPDSAPRQPDTLDSLFDDIQQKIIPGVTHWQSPNYFAYYPSNSSTAGFLGEMLSAAFNIVGFSWITSPAATELEVIVLDWFAKMLQLPSQFLSTALGGGVIQGTASEAVLVALLAARDRALKKHGKHSLEKLVVYASDQTHSALQKACQIAGIFSENVRVVIADCNKNYAVAPEAVSEALSIDLSSGLIPFFICATVGTTSSSAVDPLPELGQIAKSNDMWFHIDAAYAGSACICPEYRHHLNGVEEADSFNMNAHKWFLTNFDCSLLWVKDRSFLIQSLSTNPEFLKNKASQANSVVDFKDWQIPLGRRFRSLKLWMVLRLYGVDNLQSYIRKHIHLAEHFEQLLLSDSRFEVVTPRTFSLVCFRLVPPTSDHENGRKLNYDMMDGVNSSGKIFLSHTVLSGKFVLRFAVGAPLTEERHVDAAWKLLRDEATKVLGKMV
InterPro domains: - IPR002129: Pyridoxal phosphate-dependent decarboxylase (family) [51-424]
- IPR010977: Aromatic-L-amino-acid decarboxylase (family) [14-494]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [99-390]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [17-490]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [391-497]
- IPR021115: Pyridoxal-phosphate binding site (binding_site) [307-328]
Interaction partners: - Serotonin N-acetyltransferase 1, chloroplastic
- Serotonin N-acetyltransferase 2, chloroplastic
- histidinol-phosphate transaminase
- Aspartate aminotransferase
- Aspartate aminotransferase
- Amine oxidase
- Tryptophan aminotransferase-related protein 1
- Tryptophan aminotransferase-related protein 2
- Aspartate aminotransferase
- Aspartate aminotransferase, cytoplasmic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0001101 (response to acid chemical), GO:1901615 (organic hydroxy compound metabolic process), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009415 (response to water), GO:0046483 (heterocycle metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0018958 (phenol-containing compound metabolic process), GO:0009820 (alkaloid metabolic process), GO:0046189 (phenol-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)