Protein: Fructose-6-phosphate aldolase 2 (P32669)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize hydroxyacetone as an alternative donor substrate. Is also able to catalyze the direct self-aldol addition of glycolaldehyde. Is less catalytically efficient than the isozyme FsaA. Does not display transaldolase activity
Subcellular location: Cytoplasm
Sequence: MELYLDTANVAEVERLARIFPIAGVTTNPSIIAASKESIWEVLPRLQKAIGDEGILFAQTMSRDAQGMVEEAKRLRDAIPGIVVKIPVTSEGLAAIKILKKEGITTLGTAVYSAAQGLLAALAGAKYVAPYVNRVDAQGGDGIRTVQELQTLLEMHAPESMVLAASFKTPRQALDCLLAGCESITLPLDVAQQMLNTPAVESAIEKFEHDWNAAFGTTHL
InterPro domains: - IPR004731: Transaldolase type 3B/Fructose-6-phosphate aldolase (family) [1-215]
- IPR018225: Transaldolase, active site (active_site) [24-99]
- IPR033919: Transaldolase/Fructose-6-phosphate aldolase, archaeal/bacterial (family) [2-213]
- IPR001585: Transaldolase/Fructose-6-phosphate aldolase (family) [3-209]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-220]
- IPR023001: Fructose-6-phosphate aldolase (family) [1-220]
Interaction partners: - Multiphosphoryl transfer protein 2
- Glycerol dehydrogenase
- 6-phosphogluconate dehydrogenase, decarboxylating
- Arabinose 5-phosphate isomerase KdsD
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate 1-dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016832 (aldehyde-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0009117 (nucleotide metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0072525 (pyridine-containing compound biosynthetic process), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0019363 (pyridine nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0006531 (aspartate metabolic process), GO:0019674 (NAD metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0009435 (NAD biosynthetic process), GO:0019359 (nicotinamide nucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)