Protein: WD repeat-containing protein 55 (Q9CX97)
Organism: Mus musculus (Mouse)
Function: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:18769712}. Cytoplasm {ECO:0000269|PubMed:18769712}.
Sequence: MDPTCEESPAEDSNNEEEDLDSTKAAPRIRDTPEDIVLEAPASGLAFHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESIDCIVPVTENLLCTGSTDGIIRAVNILPNRVVGTVGQHAGEPVEALALSHCGHFLASSGHDQRLKFWDMTQLRTVVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREDEEDAKAPEEVVRESDDDDDDSD
InterPro domains: - IPR019775: WD40 repeat, conserved site (conserved_site) [311-325]
- IPR001680: WD40 repeat (repeat) [31-333]
- IPR017422: WD repeat-containing protein 55 (family) [22-387]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [39-359]
- IPR050505: WD repeat-containing protein 55/POC1 (family) [40-386]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [41-326]
Interaction partners: - Protein Red
- Ribosome biogenesis protein WDR12
- Tetratricopeptide repeat protein 27
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0002520 (immune system development), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0035295 (tube development), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0060322 (head development), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060465 (pharynx development), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0048534 (hematopoietic or lymphoid organ development), GO:0043170 (macromolecule metabolic process), GO:0055123 (digestive system development), GO:0090304 (nucleic acid metabolic process), GO:0048880 (sensory system development), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0007423 (sensory organ development), GO:0048732 (gland development), GO:0048536 (spleen development), GO:0048565 (digestive tract development), GO:0048538 (thymus development), GO:0061008 (hepaticobiliary system development), GO:0010467 (gene expression), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0001654 (eye development), GO:0001889 (liver development), GO:0006396 (RNA processing), GO:0150063 (visual system development), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0006364 (rRNA processing), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)