Protein: Sensor histidine kinase RcsC (EC 2.7.13.3) (Capsular synthesis regulator component C) (P0DMC5)
Organism: Escherichia coli (strain K12)
Function: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. RcsC has also phosphatase activity. The system controls expression of genes involved in colanic acid capsule synthesis, biofilm formation and cell division.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_00979, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2404948}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00979, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2404948}.
Sequence: MKYLASFRTTLKASRYMFRALALVLWLLIAFSSVFYIVNALHQRESEIRQEFNLSSDQAQRFIQRTSDVMKELKYIAENRLSAENGVLSPRGRETQADVPAFEPLFADSDCSAMSNTWRGSLESLAWFMRYWRDNFSAAYDLNRVFLIGSDNLCMANFGLRDMPVERDTALKALHERINKYRNAPQDDSGSNLYWISEGPRPGVGYFYALTPVYLANRLQALLGVEQTIRMENFFLPGTLPMGVTILDENGHTLISLTGPESKIKGDPRWMQERSWFGYTEGFRELVLKKNLPPSSLSIVYSVPVDKVLERIRMLILNAILLNVLAGAALFTLARMYERRIFIPAESDALRLEEHEQFNRKIVASAPVGICILRTADGVNILSNELAHTYLNMLTHEDRQRLTQIICGQQVNFVDVLTSNNTNLQISFVHSRYRNENVAICVLVDVSSRVKMEESLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPREFSPREVMNHITANYLPLVVRKQLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRADGDYLSIRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLISMMDGDISVDSEPGMGSQFTVRIPLYGAQYPQKKGVEGLSGKRCWLAVRNASLCQFLETSLQRSGIVVTTYEGQEPTPEDVLITDEVVSKKWQGRAVVTFCRRHIGIPLEKAPGEWVHSVAAPHELPALLARIYLIEMESDDPANALPSTDKAVSDNDDMMILVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLSDVNMPNMDGYRLTQRIRQLGLTLPVIGVTANALAEEKQRCLESGMDSCLSKPVTLDVIKQTLTLYAERVRKSRDS
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [523-694]
- IPR038388: RcsC, C-terminal domain superfamily (homologous_superfamily) [707-820]
- IPR019017: Signal transduction histidine kinase RcsC, alpha-beta loop, C-terminal (domain) [705-805]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [581-692]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [825-940]
- IPR005467: Histidine kinase domain (domain) [476-692]
- IPR030856: Sensor histidine kinase RcsC (family) [24-941]
- IPR036097: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (homologous_superfamily) [453-535]
- IPR011006: CheY-like superfamily (homologous_superfamily) [701-947]
- IPR004358: Signal transduction histidine kinase-related protein, C-terminal (domain) [617-689]
- IPR003661: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (domain) [467-534]
Interaction partners: - Phosphotransferase RcsD
- Outer membrane lipoprotein RcsF
- Transcriptional regulatory protein RcsB
- Transcriptional regulatory protein RcsA
- Aerobic respiration control sensor protein ArcB
- Putative membrane protein IgaA homolog
- Sensor protein EvgS
- Signal transduction histidine-protein kinase BarA
- Sensor protein TorS
- Sensor protein PhoQ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)