Protein: Bifunctional aspartate aminotransferase and L-aspartate beta-decarboxylase (EC 2.6.1.1) (EC 4.1.1.12) (Aspartate 4-decarboxylase) (ASD) (AsdA) (Q93QX0)
Organism: Comamonas testosteroni (Pseudomonas testosteroni)
Function: Bifunctional enzyme that has both L-aspartate decarboxylase and transaminase activity.
Sequence: MSKDYQSLAKLSPFELKDELIKIASSDGNRLMLNAGRGNPNFLATTPRRAFFRLGLFAAAESELSYSYMTTVGVGGLAKIDGIEGRFERYIAENRDQEGVRFLGKSLSYVRDQLGLDPAAFLHEMVDGILGCNYPVPPRMLNISEKIVRQYIIREMGADAIPSESVNLFAVEGGTAAMAYIFESLKLNGLLKAGDKVAIGMPVFTPYIEIPELAQYALEEVAINADPSLNWQYPDSELDKLKDPAIKIFFCVNPSNPPSVKMDQRSLERVRNIVAEHRPDLMILTDDVYGTFADDFQSLFAICPENTLLVYSFSKYFGATGWRLGVVAAHQQNVFDLALDKLQESEKVALDHRYRSLLPDVRSLKFIDRLVADSRAVALNHTAGLSTPQQVQMALFSLFALMDEADEYKHTLKQLIRRRETTLYRELGMPPLRDENAVDYYTLIDLQDVTAKLYGEAFSEWAVKQSSTGDMLFRIADETGIVLLPGRGFGSNRPSGRASLANLNEYEYAAIGRALRKMADELYAEYSGQAQNL
InterPro domains: - IPR022518: Aspartate 4-decarboxylase (family) [11-526]
- IPR050596: Aspartate/prephenate aminotransferase-like (family) [167-343]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [162-382]
- IPR004839: Aminotransferase, class I/classII, large domain (domain) [165-508]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [72-518]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [29-526]
- IPR004838: Aminotransferases, class-I, pyridoxal-phosphate-binding site (binding_site) [312-325]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0042802 (identical protein binding), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0009078 (pyruvate family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0006522 (alanine metabolic process), GO:0006531 (aspartate metabolic process), GO:0043648 (dicarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)