Protein: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (A5PL98)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non- canonical enol form of oxaloacetate, enol-oxaloacetate. Enol- oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Sequence: MAAVCFSLSRCCSAVHRPAVTAVRFAQTAAAPAAQPRIKKFQIYRWDPDTVGDKPRMQTYEIDLNTCGPMVLDALIKIKNEMDSTLTFRRSCREGICGSCAMNINGGNTLACLNKIDTNTSKVTKIYPLPHMYVVKDLVPDMSNFYAQYKSIEPYLKKKDESQQGKQQYLQSVEDRQKLDGLYECILCACCSTSCPSYWWNADKYLGPAVLMQAYRWMIDSRDDFTEDRLSKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMVTYKQKDAVAA
InterPro domains: - IPR001041: 2Fe-2S ferredoxin-type iron-sulfur binding domain (domain) [39-129]
- IPR036010: 2Fe-2S ferredoxin-like superfamily (homologous_superfamily) [38-141]
- IPR012675: Beta-grasp domain superfamily (homologous_superfamily) [28-141]
- IPR017900: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site (conserved_site) [185-196]
- IPR009051: Alpha-helical ferredoxin (homologous_superfamily) [142-280]
- IPR004489: Succinate dehydrogenase/fumarate reductase iron-sulphur protein (family) [43-266]
- IPR017896: 4Fe-4S ferredoxin-type, iron-sulphur binding domain (domain) [175-205]
- IPR050573: Succinate Dehydrogenase/Fumarate Reductase Iron-Sulfur (family) [26-275]
- IPR006058: 2Fe-2S ferredoxin, iron-sulphur binding site (binding_site) [92-100]
- IPR025192: Succinate dehydogenase/fumarate reductase N-terminal (domain) [40-146]
Interaction partners: - Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
- Succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial
- Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- Cytochrome c oxidase subunit 1
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
- NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
- Fumarate hydratase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016635 (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)