Protein: ubiquitinyl hydrolase 1 (EC 3.4.19.12) (D3ZN39)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKAAEECRLDRDEERAYVLYMKYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRKQLEEKDRREEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKIQRVNGEKSEGGAAAERGAVTAKELYTMMMDKNTSLIIMDARKIQDYQHSCILGSLSVPEEAISPGVTANWIEAKLSDDSKDTWKKRGSVDYVVLLDWFSSAKDLLLGTTLRSLKDALFKWESKAVLHHEPLVLEGGYENWLLCYPQFTTNAKVTPPPRSRPEEVSVSLDFTYPSLEEPVPSKLPAQMPPPPLEANEKAQLVTDQDGKPRPLVQSALAGPSVAPKAEASPIIQPVPATKNVPQVDRTKKPAVKLPEDHRMKSESTDQSGRVLSDRSTKPVFTSPATMLTDEEKARIHEETALLMEKNRQEKELWERQQKEQKEKLRREEQERKAGKTQDAEERDFTENQHKAKDGQEKRDSKQTKAEDREPPADGAQDATGTQRQSKSEHDASDAKVSVEGKRCPMSEVQKRPADVSSASSMSGELSAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSVPPSTPPTHKVKPQIPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPTVNRENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKSSLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSAAYILFYTSLGPRVTEAAT
InterPro domains: - IPR001763: Rhodanese-like domain (domain) [184-313]
- IPR015063: USP8 dimerisation domain (domain) [8-115]
- IPR036873: Rhodanese-like domain superfamily (homologous_superfamily) [180-321]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [741-1031]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [740-1069]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [736-1069]
- IPR048498: USP8, WW domain (domain) [611-643]
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [740-1072]
- IPR050185: Ubiquitin carboxyl-terminal hydrolase (family) [522-1070]
Interaction partners: - RING-type E3 ubiquitin transferase
- Receptor protein-tyrosine kinase
- Signal transducing adapter molecule 2
- E3 ubiquitin-protein ligase parkin
- Polyubiquitin-C
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin thioesterase OTUB1
- 14-3-3 protein zeta/delta
- STAM-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0009894 (regulation of catabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0070848 (response to growth factor), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0032870 (cellular response to hormone stimulus), GO:1901654 (response to ketone), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:1990089 (response to nerve growth factor), GO:0050804 (modulation of chemical synaptic transmission), GO:0048545 (response to steroid hormone), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0071363 (cellular response to growth factor stimulus), GO:1901655 (cellular response to ketone), GO:0071548 (response to dexamethasone), GO:0071383 (cellular response to steroid hormone stimulus), GO:1990090 (cellular response to nerve growth factor stimulus), GO:0031960 (response to corticosteroid), GO:0071407 (cellular response to organic cyclic compound), GO:0099170 (postsynaptic modulation of chemical synaptic transmission), GO:0071396 (cellular response to lipid), GO:0071549 (cellular response to dexamethasone stimulus), GO:0051384 (response to glucocorticoid), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0005769 (early endosome), GO:0098984 (neuron to neuron synapse), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0098978 (glutamatergic synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0097708 (intracellular vesicle)