Protein: Glutaredoxin-1 (Thioltransferase-1) (TTase-1) (P35754)
Organism: Homo sapiens (Human)
Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location: Cytoplasm.
Sequence: MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ
InterPro domains: - IPR011767: Glutaredoxin active site (active_site) [17-33]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [4-105]
- IPR014025: Glutaredoxin subgroup (domain) [15-90]
- IPR011899: Glutaredoxin, eukaryotic/virial (domain) [15-97]
- IPR047185: Glutaredoxin-1 (family) [1-106]
- IPR002109: Glutaredoxin (domain) [15-80]
Interaction partners: - Glutathione reductase, mitochondrial
- Ribonucleoside-diphosphate reductase large subunit
- Thioredoxin
- Thioredoxin reductase 1, cytoplasmic
- Glutaredoxin-related protein 5, mitochondrial
- Mitochondrial peptide methionine sulfoxide reductase
- Glutaredoxin-3
- Glutathione peroxidase 2
- Glutathione peroxidase 3
- Glutathione peroxidase 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0004601 (peroxidase activity), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0003676 (nucleic acid binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0000166 (nucleotide binding), GO:0015035 (protein-disulfide reductase activity), GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor), GO:0015036 (disulfide oxidoreductase activity), GO:0003723 (RNA binding), GO:0017076 (purine nucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0032879 (regulation of localization), GO:0044238 (primary metabolic process), GO:0050794 (regulation of cellular process), GO:0006793 (phosphorus metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006979 (response to oxidative stress), GO:0043170 (macromolecule metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0034599 (cellular response to oxidative stress), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0062197 (cellular response to chemical stress), GO:0006796 (phosphate-containing compound metabolic process), GO:0050764 (regulation of phagocytosis), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0031981 (nuclear lumen), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)