Protein: Mitochondrial DnaJ homolog 2 (P42834)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Plays a role in mitochondrial biogenesis and protein folding. Participates in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, probably by stimulating activity of mtHSP70 (SSC1).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:9325105}.
Sequence: MVLPIIIGLGVTMVALSVKSGLNAWTVYKTLSPLTIAKLNNIRIENPTAGYRDALKFKSSLIDEELKNRLNQYQGGFAPRMTEPEALLILDISAREINHLDEKLLKKKHRKAMVRNHPDRGGSPYMAAKINEAKEVLERSVLLRKR
InterPro domains: - IPR001623: DnaJ domain (domain) [84-146]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [72-142]
Interaction partners: - Mitochondrial import inner membrane translocase subunit TIM44
- DnaJ homolog 1
- Mitochondrial import inner membrane translocase subunit TIM16
- Import motor subunit, mitochondrial
- GrpE protein homolog
- J domain-containing protein 1
- Mitochondrial import inner membrane translocase subunit TIM17
- Mitochondrial import inner membrane translocase subunit TIM21
- Mitochondrial import inner membrane translocase subunit TIM14
- Mitochondrial import inner membrane translocase subunit TIM50
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060590 (ATPase regulator activity), GO:0005515 (protein binding), GO:0140677 (molecular function activator activity), GO:0001671 (ATPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0022413 (reproductive process in single-celled organism), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0043934 (sporulation), GO:0009653 (anatomical structure morphogenesis), GO:1903046 (meiotic cell cycle process), GO:0032505 (reproduction of a single-celled organism), GO:0051321 (meiotic cell cycle), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0030435 (sporulation resulting in formation of a cellular spore), GO:0016043 (cellular component organization), GO:0030437 (ascospore formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0034293 (sexual sporulation), GO:0043935 (sexual sporulation resulting in formation of a cellular spore), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)