Protein: SOS Ras/Rac guanine nucleotide exchange factor 1 (A0A8I6B4D6)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MWRFVFKGQCSTHLIVHTSWEFVKGFTIATSTGSEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPAERIHHLLREVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSSYDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDVLRPGFHERFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECMKQAITALLNVQSGMEKICSKNLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEHMRLPSADVYRFAEPDSEENILFEENVQPKAGIPIIKAGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDVDLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQNSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASSASSNTDVCSVFDSDHSASPFHSRSASVSSISLSKGTEEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQLIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [9-141]
- IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [723-983]
- IPR000219: Dbl homology domain (domain) [164-354]
- IPR001849: Pleckstrin homology domain (domain) [407-512]
- IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [740-984]
- IPR019804: Ras guanine-nucleotide exchange factor, conserved site (conserved_site) [891-924]
- IPR008937: Ras-like guanine nucleotide exchange factor (family) [384-993]
- IPR000651: Ras-like guanine nucleotide exchange factor, N-terminal (domain) [560-705]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [407-505]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [162-383]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [531-1007]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [384-493]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0019904 (protein domain specific binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005102 (signaling receptor binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0070851 (growth factor receptor binding), GO:0017124 (SH3 domain binding), GO:0030695 (GTPase regulator activity), GO:0005154 (epidermal growth factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0035556 (intracellular signal transduction), GO:0010646 (regulation of cell communication), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0010647 (positive regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0002931 (response to ischemia), GO:0038179 (neurotrophin signaling pathway), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:1901184 (regulation of ERBB signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007264 (small GTPase mediated signal transduction), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:1901186 (positive regulation of ERBB signaling pathway), GO:0042058 (regulation of epidermal growth factor receptor signaling pathway), GO:0007265 (Ras protein signal transduction), GO:0045742 (positive regulation of epidermal growth factor receptor signaling pathway), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0051057 (positive regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0043025 (neuronal cell body), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0032279 (asymmetric synapse)