Protein: Myocyte enhancer factor 2ca (Q6PCS3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MGRKKIQIARIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDIDAEDSGHSPESEDKYRKINEDIDLMISRQRLCAIPQSNYDMPVSIPVSNPNSLIYGHPGASLGNPNLLPLTHPSLQRNSMSPGVTHRPPSAGNTGGLMAADLGSGAGTSTGNGYGNHRNSPGLLVSPGNMSKNLQAKSPPSMNMSLSRKPDLRVLIPPGAKNTMPSINQRISSSQSAQSLSTPVVSVATPTLPGEVMGGYPSAINTSYGTEYSLSSGDLSSLSAFNSSASLHLGSMTGWPQNMQHSGLGHLGNCSSAQLCQSSALSLPSNQNLHIKSEPVSPPRDRASGTPGLYGVPQQTPLRQDSGRSPVDSLSSCGSSYDGSDRDEHRANFHSPVGLMRAAENERQSPSVKRMRLSEAGWAS
InterPro domains: - IPR036879: Transcription factor, MADS-box superfamily (homologous_superfamily) [2-94]
- IPR022102: Holliday junction regulator protein family C-terminal (domain) [95-153]
- IPR033896: MADS MEF2-like, N-terminal (domain) [2-78]
- IPR002100: Transcription factor, MADS-box (domain) [1-61]
Interaction partners: - T-box transcription factor TBX5-A
- Mitogen-activated protein kinase 14B
- mitogen-activated protein kinase
- mitogen-activated protein kinase
- mitogen-activated protein kinase
- Mitogen-activated protein kinase 14A
- Mitogen-activated protein kinase 12
- Myocyte enhancer factor 2cb
- Heart- and neural crest derivatives-expressed protein 2
- Myoblast determination protein 1 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0001503 (ossification), GO:0030029 (actin filament-based process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0048645 (animal organ formation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0051216 (cartilage development), GO:1901362 (organic cyclic compound biosynthetic process), GO:0055006 (cardiac cell development), GO:0048705 (skeletal system morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0055001 (muscle cell development), GO:0019438 (aromatic compound biosynthetic process), GO:0061448 (connective tissue development), GO:0031033 (myosin filament organization), GO:0030239 (myofibril assembly), GO:0060536 (cartilage morphogenesis), GO:0010468 (regulation of gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0060914 (heart formation), GO:0060348 (bone development), GO:0003007 (heart morphogenesis), GO:0042692 (muscle cell differentiation), GO:0001501 (skeletal system development), GO:0090304 (nucleic acid metabolic process), GO:0072359 (circulatory system development), GO:0018130 (heterocycle biosynthetic process), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0071688 (striated muscle myosin thick filament assembly), GO:0060349 (bone morphogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0043933 (protein-containing complex organization), GO:0045667 (regulation of osteoblast differentiation), GO:0006996 (organelle organization), GO:0035051 (cardiocyte differentiation), GO:0031032 (actomyosin structure organization), GO:0010467 (gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0097435 (supramolecular fiber organization), GO:0007507 (heart development), GO:0070925 (organelle assembly), GO:0016070 (RNA metabolic process), GO:0014866 (skeletal myofibril assembly), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0031034 (myosin filament assembly), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0055013 (cardiac muscle cell development), GO:0007010 (cytoskeleton organization), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0055002 (striated muscle cell development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0140694 (non-membrane-bounded organelle assembly), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)