Protein: Synapsin-2 (Synapsin II) (Q64332)
Organism: Mus musculus (Mouse)
Function: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.
Subcellular location: Synapse.
Sequence: MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPAPGPGAATASAATSAASPGPERRPPPAQAPAPQPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPSAASRKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLVIGMQYAGLPSINSLESIYNFCDKPWVFAQMVAIFKTLGGEKFPLIEQTYYPNHREMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDACSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITDLVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKEPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPSGPSLPSSSSSSSSSSSSSSAPQRPGGPTTTHGDASSSSNSLAEAQAPQAAPAQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD
InterPro domains: - IPR019735: Synapsin, conserved site (conserved_site) [272-282]
- IPR016185: Pre-ATP-grasp domain superfamily (homologous_superfamily) [113-214]
- IPR001359: Synapsin (family) [126-371]
- IPR020898: Synapsin, ATP-binding domain (domain) [215-417]
- IPR020897: Synapsin, pre-ATP-grasp domain (domain) [111-213]
- IPR019736: Synapsin, phosphorylation site (ptm) [2-30]
- IPR013815: ATP-grasp fold, subdomain 1 (homologous_superfamily) [249-308]
Interaction partners: - Synaptosomal-associated protein 25
- Vesicle-associated membrane protein 2
- Syntaxin-1A
- Complexin-1
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 4
- Beta-soluble NSF attachment protein
- Syntaxin-4
- Syntaxin-3
- Vesicle-associated membrane protein 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0007154 (cell communication), GO:0099536 (synaptic signaling), GO:0099537 (trans-synaptic signaling), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0070382 (exocytic vesicle), GO:0043005 (neuron projection), GO:0030672 (synaptic vesicle membrane), GO:0098984 (neuron to neuron synapse), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0032279 (asymmetric synapse), GO:0097708 (intracellular vesicle), GO:0099501 (exocytic vesicle membrane), GO:0030424 (axon)