Protein: N-alpha-acetyltransferase 20 (EC 2.3.1.254) (Methionine N-acetyltransferase) (N-acetyltransferase 5) (N-terminal acetyltransferase B complex catalytic subunit NAA20) (N-terminal acetyltransferase B complex catalytic subunit NAT5) (NatB complex subunit NAT5) (NatB catalytic subunit) (P61599)
Organism: Homo sapiens (Human)
Function: Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18570629, ECO:0000269|PubMed:25732826}. Nucleus {ECO:0000269|PubMed:18570629, ECO:0000269|PubMed:25732826}.
Sequence: MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
InterPro domains: - IPR051646: N-terminal NatB acetyltransferase catalytic subunit (family) [1-177]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [1-156]
- IPR000182: GNAT domain (domain) [2-157]
Interaction partners: - N-alpha-acetyltransferase 25, NatB auxiliary subunit
- N-alpha-acetyltransferase 15, NatA auxiliary subunit
- N-alpha-acetyltransferase 30
- N-alpha-acetyltransferase 50
- N-alpha-acetyltransferase 35, NatC auxiliary subunit
- N-alpha-acetyltransferase 40
- N-alpha-acetyltransferase 16, NatA auxiliary subunit
- N-alpha-acetyltransferase 60
- N-alpha-acetyltransferase 10
- N-alpha-acetyltransferase 38, NatC auxiliary subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity), GO:0004596 (peptide alpha-N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0010639 (negative regulation of organelle organization), GO:0043412 (macromolecule modification), GO:0031344 (regulation of cell projection organization), GO:0006325 (chromatin organization), GO:0032880 (regulation of protein localization), GO:0031345 (negative regulation of cell projection organization), GO:0006996 (organelle organization), GO:0006338 (chromatin remodeling), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:0006473 (protein acetylation), GO:0018205 (peptidyl-lysine modification), GO:0010975 (regulation of neuron projection development), GO:0018394 (peptidyl-lysine acetylation), GO:0006475 (internal protein amino acid acetylation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)