Protein: Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) (P48768)
Organism: Rattus norvegicus (Rat)
Function: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells (By similarity). Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Plays a role in regulating urinary Ca(2+) and Na(+) excretion (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16914199, ECO:0000269|PubMed:8021246, ECO:0000269|PubMed:9486131}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K596}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K596}. Perikaryon {ECO:0000269|PubMed:16914199}. Cell projection, dendrite {ECO:0000269|PubMed:16914199}. Cell projection, dendritic spine {ECO:0000269|PubMed:16914199}.
Sequence: MAPLALVGVALLLGAPHCLGEATPTPSLPPPPANDSDASPGGCQGSYRCQPGVLLPVWEPDDPSLGDKAARAVVYFVAMVYMFLGLSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPGANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGISALLLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPSCFDYVMHFLTVFWKVLFACLPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAVLLYRRRPHIGGELGGPRGPKLATTALFLGLWFLYILFASLEAYCHIRGF
InterPro domains: - IPR038081: CalX-like domain superfamily (homologous_superfamily) [385-674]
- IPR032452: Sodium/calcium exchanger domain, C-terminal extension (domain) [248-378]
- IPR004837: Sodium/calcium exchanger membrane region (domain) [75-910]
- IPR004836: Sodium/calcium exchanger protein (family) [1-921]
- IPR003644: Na-Ca exchanger/integrin-beta4 (domain) [383-619]
- IPR051171: Calcium/Cation Antiporter (family) [35-920]
- IPR044880: NCX, central ion-binding domain superfamily (homologous_superfamily) [125-912]
Interaction partners: - Sodium/calcium exchanger 3
- Sodium/calcium exchanger 1
- cAMP-dependent protein kinase catalytic subunit alpha
- cAMP-dependent protein kinase catalytic subunit beta
- cGMP-dependent protein kinase 2
- Mitochondrial sodium/calcium exchanger protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015368 (calcium:monoatomic cation antiporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005432 (calcium:sodium antiporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0050801 (monoatomic ion homeostasis), GO:0001666 (response to hypoxia), GO:0070482 (response to oxygen levels), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0055082 (intracellular chemical homeostasis), GO:0098739 (import across plasma membrane), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0140115 (export across plasma membrane), GO:0098655 (monoatomic cation transmembrane transport), GO:0071417 (cellular response to organonitrogen compound), GO:0046683 (response to organophosphorus), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:0099587 (inorganic ion import across plasma membrane), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0055074 (calcium ion homeostasis), GO:0006851 (mitochondrial calcium ion transmembrane transport), GO:0051591 (response to cAMP), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0055080 (monoatomic cation homeostasis), GO:0036293 (response to decreased oxygen levels), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0006812 (monoatomic cation transport), GO:0098659 (inorganic cation import across plasma membrane), GO:0071320 (cellular response to cAMP), GO:0071407 (cellular response to organic cyclic compound), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0070588 (calcium ion transmembrane transport), GO:0036294 (cellular response to decreased oxygen levels), GO:0006816 (calcium ion transport), GO:0014074 (response to purine-containing compound), GO:0098703 (calcium ion import across plasma membrane), GO:0030001 (metal ion transport), GO:0097553 (calcium ion transmembrane import into cytosol), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0099080 (supramolecular complex), GO:0031975 (envelope), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0019867 (outer membrane), GO:0043228 (non-membrane-bounded organelle), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0005739 (mitochondrion), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099081 (supramolecular polymer), GO:0097060 (synaptic membrane), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0042383 (sarcolemma), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0031968 (organelle outer membrane), GO:0099512 (supramolecular fiber), GO:0031966 (mitochondrial membrane), GO:0099513 (polymeric cytoskeletal fiber), GO:0005741 (mitochondrial outer membrane), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0044309 (neuron spine), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)