Protein: WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1) (P59328)
Organism: Mus musculus (Mouse)
Function: Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.
Subcellular location: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O75717}.
Sequence: MPATQKPMRYGHTEGHTEVCFDDSGSYIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGVPDGILTRFTTNANHVVFNGAGNKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDIFLASASCDGTVRVWNISDQTCAVSWPVLQKSNDVVNAKSICRLAWQPKAGKLLAVPVEKSVKLYRRETWSNPFDLSDSSISQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKDCMERVKHEKGYAICGLAWHPTCSRICYTDVEGNLGVLENVCDLSGKVSSNKVSSRVEKDYNDLFDGDDTSSAGDFLNDNAVEIPSFSKGIINEDDDNDDIMLAADHDLGDDENSVDVTMLKADLSHKEEGDDDQARSIHNLPLIRPQRPFYDGPMPTPRQKPFQSSSTPLHLSHRFMVWNSVGIIRCYNDDQDSAIDVEFHDTSIHHATHLLNAFNYTMGTLSHEAILLACESADELASKLHCLHFSSWDSSKEWMVDMPQNEDIEAICLGLGWAAAATTALLLRLFTIGGVQKEVFCLPGPVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKNQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAETQSEEEKEEDFREKLNAGYSHTTTEWSRPRVRSQVEDAEDREDTVSEEKPESHNHGQNLFQSANSSDTPALKSGAVFSSSQGWVNPFKVVVSSKEPAVSANSTRSANILDSMNKSSRKSTSLNRMENNEKSPVIKPLTPKPRSKQASAASYFQKRTPQADKTEEVKENPKSSSSDAPAVCLQNSENQRPKTGFQMWLEENRSQILSDNPDISDETDIIKEGMIRFRVLSAEERKAWTNKAKGETASDGAEAKKRKRVVSEICETENQEETVKENLDLSKKQKALNLPANQKLSAFAFKQ
InterPro domains: - IPR019775: WD40 repeat, conserved site (conserved_site) [151-259]
- IPR001680: WD40 repeat (repeat) [4-301]
- IPR009071: High mobility group box domain (domain) [1003-1073]
- IPR055339: WD repeat and HMG-box DNA-binding protein 1, HMG-box (domain) [1003-1065]
- IPR057646: WDHD1, first WD40 domain (domain) [9-299]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [3-302]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [1002-1060]
- IPR022100: WDHD1/CFT4, second beta-propeller (domain) [424-707]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [9-297]
- IPR048591: WDHD1/CFT4, helical bundle (domain) [716-815]
Interaction partners: - DNA polymerase alpha catalytic subunit
- DNA replication licensing factor MCM4
- TIMELESS-interacting protein
- Cell division control protein 45 homolog
- DNA replication licensing factor MCM3
- DNA replication complex GINS protein SLD5
- DNA replication licensing factor MCM5
- DNA replication complex GINS protein PSF3
- Protein timeless homolog
- DNA replication licensing factor MCM6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0090304 (nucleic acid metabolic process), GO:0000723 (telomere maintenance), GO:0051276 (chromosome organization), GO:0032200 (telomere organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)