Protein: Aminopeptidase 2 (Q59KZ1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Metalloprotease that specifically hydrolyzes peptides with N- terminal alanine, arginine and leucine residues
Subcellular location: Secreted, cell wall
Sequence: MASNNTSQRSGFSSFFCRLKTYFCNHFLCLFVLSFFPLSFRRLCLLCHLCEKSNLWLSSDNSASVVKQEREVLPTNVKPLHYDLTIEPIFDNFTFKGEETIDFQVNEKTNFITLNSLEIEVQEAKIDGKSVTDISFDAGKQTVTFKFDDDLSTGSIAKLYIKFTGELNDKMAGFYRASYQEDGKTKYMATTQMEPTDCRRAFPSYDEPAAKSKFTISLIADKELVCLSNSSEKETVSLDGNKKKVTFQTTPLMSTYLVAFIVGDLRYISNDNYRVPIRVYSTPGTEHLGEYSANIAAQTLKFFDQQFGIDYPYDKLDMVAVPSFSAGAMENCGLVTFRTVDLLIDADNANVNTKQRVTEVVMHELAHQWFGDLVTMEFWDGLWLNEGFATWMSWYACNSLYPDWKVWESYVSDSLQHALTLDALRASHPIEVPVKRADEINQIFDAISYSKGSSLLRMISKWLGEDVFVKGVSNYLKKHKWGNTKTSDLWEALSEASGEDVVKVMDIWTKNIGFPIVKVEEIGNGEIKVTQNRFLATGDVKESEDKTLYPVFLGLKTSEGVDESSVLETRSKTIKLPTSDDFFKINGDQSGIYRTAYEPARWTKLGKAGVEGKLSVEDRVGLVADAGSLASSGFIKTSSLLDLVKSWSKESNYVVWNEILTRIGSIKAALMFEDEATKKALEIFTRDLISEKLKETGWEFSADDSFADQQLKSSLFASAANAEDPEAVAFAKEAFAKFIAGDKKAIHPNLRASIFNTNAKYGDEKTFDELYNIYRNPSSVEEKIAALRSFGRFTKPEILDKVTGLLLQTDIVKQQDIYIPMQGLRAHKLGVEKLWTWLSENWDQIYILLPPGLSMLGSVVTLGTSGFTKEEQKKKVEEFFAQKDNKGYDQSLAQSLDIITAKSKWTDRDAKSIYEWLEANEYTK
InterPro domains: - IPR034016: Aminopeptidase N-type (family) [80-510]
- IPR050344: Peptidase M1 family aminopeptidases (family) [61-918]
- IPR027268: Peptidase M4/M1, CTD superfamily (homologous_superfamily) [268-513]
- IPR045357: Aminopeptidase N-like , N-terminal domain (domain) [78-257]
- IPR024571: ERAP1-like C-terminal domain (domain) [582-900]
- IPR001930: Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (family) [199-391]
- IPR014782: Peptidase M1, membrane alanine aminopeptidase (domain) [291-508]
- IPR042097: Aminopeptidase N-like , N-terminal domain superfamliy (homologous_superfamily) [58-264]
Interaction partners: - 14-3-3 protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity), GO:0008235 (metalloexopeptidase activity), GO:0070006 (metalloaminopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0006518 (peptide metabolic process), GO:0006508 (proteolysis), GO:1901565 (organonitrogen compound catabolic process), GO:0043171 (peptide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)