Protein: Structural maintenance of chromosomes protein 5 (Protein EMBRYO DEFECTIVE 2782) (Q9LFS8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of the SMC5-SMC6 complex that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates with chromatin. {ECO:0000250}.
Sequence: MSERRAKRPKISRGEDDFLPGNIIEIELHNFMTFNHLVCKPGSRLNLVIGPNGSGKSSLVCAIALCLGGEPQLLGRATSVGAYVKRGEDSGYVKISLRGNTREENLTIFRKIDTRNKSEWMFNGSTVSKKDIVEIIQKFNIQVNNLTQFLPQDRVCEFAKLTPVQLLEETEKAVGDPQLPVHHRALVEKSRDLKQLERAVAKNGETLNQLKALVDEQEKDVERVRQRELFLTKVDSMKKKLPWLKYDMKKAEYMDAKKRMKEAEKKLDEAAKNLNSMKEPIEKQKKEKAETDSKCKKVKNLMDANGRNRCHLLEKEDEADARVVATYKELEELKKQEEHRQERILKATEDLVAAERELQNLPVYERPVAKLEELSSQVTELHHSINGKKNQKEDNEKLLSQKRYTLRQCVDKLKDMENANNKLLKALANSGADRIFDAYQWVQQNRHEFKREVYGPVLVEVNVPNRENACFLEGHVSFYIWKSFITQDPEDRDLLVKNLKRFDVPVLNYVGNSGNQKAPFHISDQMRSLGIHARLDQIFDAPDAVKEVLNSQFGLEDSYIGSKITDQRAEEVYKLGIKDFWTPDNHYRWSSSRYGGHSSASVDSVYQSRLLLCGVDVGELEKLRSRKEELEDSILFMEETHKSLQTEQRRLEEEAAKLHKEREEIVNVSYLEKKKRRELESRYQQRKTKLESLEQEEDMDASVAKLIDQASRANADRYTYAINLKKLLVEAVAHKWSYAEKHMASIELERKIRESEINIKQYEKTAQQLSLAVEYCKKEVEGKQQRLATAKRDAESVATITPELKKEFMEMPTTVEELEAAIQDNLSQANSILFINENILQEYEHRQSQIYTISTKLETDKRDLSICMKEIDSLKEKWLPTLRQLVGQINETFSHNFQEMAVAGEVSLDERDTDFDQYGIHIKVKFRESGQLQVLSSHHQSGGERSVSTILYLVSLQDLTNCPFRVVDEINQGMDPINERKMFQQLVRAASQPNTPQCFLLTPKLLPELEYSEACSILNIMNGPYIAEPSKVWSLGDSWGSLNRRRTEASQCS
InterPro domains: - IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [22-1021]
- IPR003395: RecF/RecN/SMC, N-terminal (domain) [23-989]
Interaction partners: - E3 SUMO-protein ligase MMS21
- Non-structural maintenance of chromosomes element 4 homolog A
- Non-structural maintenance of chromosomes element 4 homolog B
- Structural maintenance of chromosomes protein 6A
- Structural maintenance of chromosomes protein 6B
- Structural maintenance of chromosomes protein 3
- Non-structural maintenance of chromosomes element 1 homolog
- Sister chromatid cohesion protein SCC2
- Protein CHROMOSOME TRANSMISSION FIDELITY 7
- Sister chromatid cohesion 1 protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0051304 (chromosome separation), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0000723 (telomere maintenance), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0032200 (telomere organization), GO:0006312 (mitotic recombination), GO:0000725 (recombinational repair), GO:0006302 (double-strand break repair), GO:0000724 (double-strand break repair via homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)