Protein: Aminopeptidase (EC 3.4.11.-) (B0BCZ2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004401}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
Sequence: MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPNHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
InterPro domains: - IPR001930: Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase (family) [228-421]
- IPR024571: ERAP1-like C-terminal domain (domain) [616-933]
- IPR045357: Aminopeptidase N-like , N-terminal domain (domain) [99-286]
- IPR034016: Aminopeptidase N-type (family) [100-540]
- IPR050344: Peptidase M1 family aminopeptidases (family) [60-950]
- IPR014782: Peptidase M1, membrane alanine aminopeptidase (domain) [321-538]
- IPR042097: Aminopeptidase N-like , N-terminal domain superfamliy (homologous_superfamily) [76-294]
- IPR027268: Peptidase M4/M1, CTD superfamily (homologous_superfamily) [295-543]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity), GO:0008235 (metalloexopeptidase activity), GO:0070006 (metalloaminopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048870 (cell motility), GO:0008283 (cell population proliferation), GO:0003008 (system process), GO:0008217 (regulation of blood pressure), GO:0003013 (circulatory system process), GO:0016477 (cell migration), GO:0050886 (endocrine process), GO:0008015 (blood circulation), GO:0001990 (regulation of systemic arterial blood pressure by hormone), GO:0003073 (regulation of systemic arterial blood pressure), GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin), GO:0003044 (regulation of systemic arterial blood pressure mediated by a chemical signal)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0005764 (lysosome), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)