Protein: Transforming acidic coiled-coil protein, isoform K (A0A0B4JD97)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MDFLANIIKRPKSIATTGISTNQPTTMEALEAASPADECSTPRDKGGVTLVSAHLDSLLESASEELQRLEGKHCELFMESISNPLPAPEDSTDSREEIQKFLSEINFNLNQVSANEMEHLQAMSGELSPLAVKPSPKPTSMDQQKAMAAALGHQTAVPGGLKPEDDLVPKFGGLPEFDETQIPELAPLSTDMDTQLKSNHSDSDVFVECLSLHSERYTGDRSELEAYSSALNDVLEQQLSMTSVSTLGAEFNDPLAVSQHNNVSYEAMDVDDLNETMEMLKDVLNAEDRHLMQTHILSVTQSKPENNFVHYHPNQEQNRVELDQLAKHSKPNSDAKESESLVESVLSEESGTQSFEPKLTLSALDSTKDLAKHQEEMQTNTKDIFQKEKHHPVSSAQVKDAQNPKEPEKALNLKEASSELSTKSAKSLEYPNQEKQFSVAVESMERPCTAISLEQNASPAMEATEDRTVEELDQMDVDESMKVDDATVLNSCRQEQINAHSPVSSKFFLKLCVQNDTDCQDNKMDQKTAGKESALKMTEIELPVESVPSASLSPPTPALQAKIIELSLSPPIPTHRPKTAEELEFLALRELPLPDGVSTAGKVECKQLSHGLVPIVAVLPTPLYLDLKGNTTTASLPEPTSPSFPIKEPAEKQSHFPRSPRAQLEQKDMPYLEEAVVERSSHRKQSDFGVIAKSPIVFELTQPSPEKQHLNETLPMSEISPTSSNMTFDSGSITEDKSQKGTENIEPSSTLAVSLGSVDDKQRRTFSVVQPTKEEEEAKSRRTFCMENENPRRTFCMQQNASPAVEATEDTGADEVMDVDISMRADEVAVMKSHQQTWKERQAPISNSPPIPTHQRLNRPPEAISPVSPLGNGTVVLEEQTLSAKEQATLSASDEKDDVFLEHFGAISPVSDDMFKTSSASNNQAKFRVNADEETGGKGASAMIRKRSGTAGEQEEIFDAEFHDGVNNQNLILNSSDFDYLYTKGSNSVPIDRSSLLLKFDPLLGAPVPVNHPNQQEQALQNILGSNQHQNRLLSPTLEEHETSDGNQSFGVISSAKDTAKKWDFKPPVDRTKKHVKMSVDVIDNDCNKTFDNSNTNTEDKTHNYNDMDELEKKIKNEVTRSEDIEKKLKEGELREEALIKRITEKDKTNAKLNGVIEAYEKAIAELISEKEQQAQLHERQLQEVQADRDANYHHLTSLETTFSDLHVKYEKSKEMTSQLKSNEESLLAERKQMMDNLRLQEQRYDKMKNHAMQQLEIANKKLDTYSREHADETKKLKALLKKEEISRVSMTEQLQQKSRENADLLKICEELIYGKGQGGSS
InterPro domains: - IPR039915: TACC family (family) [5-1316]
- IPR007707: Transforming acidic coiled-coil-containing protein, C-terminal (domain) [1103-1313]
Interaction partners: - Protein mini spindles
- Aurora kinase
- Centrosomin
- Protein claret segregational
- Alkaline phosphatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0009566 (fertilization), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0033036 (macromolecule localization), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:1903046 (meiotic cell cycle process), GO:0007017 (microtubule-based process), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0051640 (organelle localization), GO:0035046 (pronuclear migration), GO:0007276 (gamete generation), GO:0007279 (pole cell formation), GO:0051129 (negative regulation of cellular component organization), GO:1903047 (mitotic cell cycle process), GO:0007349 (cellularization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007051 (spindle organization), GO:0051649 (establishment of localization in cell), GO:0000226 (microtubule cytoskeleton organization), GO:0032886 (regulation of microtubule-based process), GO:0140013 (meiotic nuclear division), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0007143 (female meiotic nuclear division), GO:0007277 (pole cell development), GO:0051128 (regulation of cellular component organization), GO:0000278 (mitotic cell cycle), GO:0007338 (single fertilization), GO:0051647 (nucleus localization), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0043244 (regulation of protein-containing complex disassembly), GO:0007052 (mitotic spindle organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0007292 (female gamete generation), GO:0007097 (nuclear migration), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:1901879 (regulation of protein depolymerization), GO:0031114 (regulation of microtubule depolymerization), GO:0048285 (organelle fission), GO:1901880 (negative regulation of protein depolymerization), GO:0031111 (negative regulation of microtubule polymerization or depolymerization), GO:0007010 (cytoskeleton organization), GO:0007026 (negative regulation of microtubule depolymerization), GO:0006997 (nucleus organization), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0048284 (organelle fusion), GO:0000280 (nuclear division), GO:0000741 (karyogamy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000922 (spindle pole), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0005881 (cytoplasmic microtubule), GO:0005818 (aster), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0099081 (supramolecular polymer), GO:0000235 (astral microtubule), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0005876 (spindle microtubule)