wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Erythrocyte membrane protein band 4.1 like 2 (A0A2R8Y5B3)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: SEVKKDSSQLGTDATKEKPKEVAENQQNQSSDPEEEKGSQPPPAAESQSSLRRQKREKETSESRGISRFIPPWLKKQKSYTLVVAKDGGDKKEPTQAVVEEQVLDKEEPLPEEQRQAKGDAEEMAQKKQEIKVEVKEEKPSVSKEEKPSVSKVEMQPTELVSKEREEKVKETQEDKLEGGAAKRETKEVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTLGSKFRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKTVSMCPPSPLIHRTSSFSPNLLPVPEMDLLSDISEEDPFGEADQITLDSLEHLSTGEISEQGDSEVAMPDLVLDSAIAPSQPDCPSPIHGKTLKAADDSDSEFGYFSFSFSKCFPSGFPSLLDEDGYLAFPSLPKVWVSFLPAGVQHYVPITSPSFIPSLILIFGLLLSASQSVPFSLAFSLPLALSLCYLEAKAASFNVSYDCDLNDKLEEEEVVAGMPT
InterPro domains: - IPR035963: FERM superfamily, second domain (homologous_superfamily) [291-396]
- IPR019747: FERM conserved site (conserved_site) [264-400]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [211-290]
- IPR000798: Ezrin/radixin/moesin-like (family) [223-424]
- IPR018979: FERM, N-terminal (domain) [214-276]
- IPR000299: FERM domain (domain) [210-491]
- IPR019749: Band 4.1 domain (domain) [206-401]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [288-395]
- IPR018980: FERM, C-terminal PH-like domain (domain) [405-495]
- IPR014847: FERM adjacent (domain) [498-544]
- IPR019748: FERM central domain (domain) [292-401]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [396-490]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: NAD(P)H quinone oxidoreductase PST2 (EC 1.6.5.2) (Flavodoxin-like protein PST2) (FLP PST2) (Q59Y37)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Subcellular location: Cell membrane {ECO:0000269|PubMed:26325183}; Peripheral membrane protein {ECO:0000269|PubMed:26325183}.
Sequence: MSKPRVAIIIYSLYHHVYTLAESAKIGIEAAGVKPDLFQVPETLTPEILKLVKAPPKPDIPIAEPKILNNYDAFLFGIPTRFGNMPAQWKGFWDGTGGQWARGDLRGKYAGVFVSTGTPGGGQETTVINTLSTLAHHGIVYVPFGYGSPRLADLNEVHGGSPWGAGTFAGADGSREVTELEKSIAQQQGEDFIKTITQFKQ
InterPro domains: - IPR029039: Flavoprotein-like superfamily (homologous_superfamily) [2-201]
- IPR005025: NADPH-dependent FMN reductase-like domain (domain) [18-143]
- IPR008254: Flavodoxin/nitric oxide synthase (domain) [6-192]
- IPR010089: Flavoprotein WrbA-like (family) [5-193]
Interaction partners: - NAD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0034599 (cellular response to oxidative stress), GO:0062197 (cellular response to chemical stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Metal transporter Nramp1 (AtNramp1) (Q9SAH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: High affinity manganese (Mn) transporter involved in Mn acquisition from the soil. Required for Mn uptake into the root in conditions of low Mn availability. Can transport iron (Fe), cadmium (Cd) and cobalt (Co).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20228245}; Multi-pass membrane protein {ECO:0000269|PubMed:20228245}.
Sequence: MAATGSGRSQFISSSGGNRSFSNSPLIENSDSNQIIVSEKKSWKNFFAYLGPGFLVSIAYIDPGNFETDLQAGAHYKYELLWIILVASCAALVIQSLAANLGVVTGKHLAEQCRAEYSKVPNFMLWVVAEIAVVACDIPEVIGTAFALNMLFSIPVWIGVLLTGLSTLILLALQKYGVRKLEFLIAFLVFTIAICFFVELHYSKPDPGEVLHGLFVPQLKGNGATGLAISLLGAMVMPHNLFLHSALVLSRKIPRSASGIKEACRFYLIESGLALMVAFLINVSVISVSGAVCNAPNLSPEDRANCEDLDLNKASFLLRNVVGKWSSKLFAIALLASGQSSTITGTYAGQYVMQGFLDLRLEPWLRNLLTRCLAIIPSLIVALIGGSAGAGKLIIIASMILSFELPFALVPLLKFTSCKTKMGSHVNPMAITALTWVIGGLIMGINIYYLVSSFIKLLIHSHMKLILVVFCGILGFAGIALYLAAIAYLVFRKNRVATSLLISRDSQNVETLPRQDIVNMQLPCRVSTSDVD
InterPro domains: - IPR001046: NRAMP family (family) [31-491]
Interaction partners: - Fe
- Putative cadmium/zinc-transporting ATPase HMA4
- Ferric reduction oxidase 2
- Metal tolerance protein 11
- Solute carrier family 40 member 1
- Putative metal tolerance protein C3
- Vacuolar iron transporter 1
- Metal tolerance protein 1
- Protein DETOXIFICATION 43
- Probable ferric reduction oxidase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005384 (manganese ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:0009624 (response to nematode), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015851 (nucleobase transport), GO:0006863 (purine nucleobase transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ferric-chelate reductase (NADPH) (EC 1.16.1.9) (A0A1D8PKY2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MAIPFDQQFFVEKDRNNKYEWLIFVLTFIVLAGHGILFYWIPRYLRVNNKRNNYFRLLKVWDAWTSCVHVWGDFYFQPSLVLLGILFVGLNVGFCFAEINDLDYQSRFYIISKRLSKVAVGNLPILLFAVMKNDLLTSITGLQHDRLEFVHKWLSRLMWVMITIHMGMACYYWLNLNFKIMIMIPPQIFGFMAYGSFSILNWASLKFIRQFAYDFFLVQHRIFAFMMLFFTFIHNQGNRAVVLISVHGLVIDRVVSKVFAYLHAKKSPTKGRCTFRIIDDSTISVVIPVSEAGYTSKSWYTRFLPKYKTWKAGQHIYLNVGKIKFFQYHPFTISSLAESGEMKLLIRVERGFTRKLMRHLEQVDHDEVTIKAMFHGPYGARYQPLITFDTCLFFAAGSGGAFTFPVCLDLLNQIDRRDQEGDVLFRPKNQFIKFVWAIRKQDNIEWFEDSLKQFAGRCSVDIYITQETKEELPLQRKNSIIEITKSLTNDYNILYGRPQIQDIIQQHSQSLGANQSMAVTSCGSPSFTNSIKHHCQSARRVKGAPEVYCYTESF
InterPro domains: - IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [304-380]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [270-384]
- IPR051410: Ferric/Cupric Reductase Transmembrane Component (family) [5-554]
- IPR013121: Ferric reductase, NAD binding domain (domain) [388-535]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [373-554]
- IPR013112: FAD-binding 8 (domain) [305-380]
- IPR013130: Ferric reductase transmembrane component-like domain (domain) [118-230]
Interaction partners: - Fth1p
- Siderophore transporter
- GPI-anchored hemophore PGA7
- High-affinity iron permease
- GPI-anchored hemophore RBT5
- Fre9p
- Hap43p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016722 (oxidoreductase activity, acting on metal ions), GO:0000293 (ferric-chelate reductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Pseudouridine synthase (EC 5.4.99.-) (F4KBV6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MKRKQQEDDNDDGVEKAVSPVLATTSNTMSTDLLLQSSSKLSQKQDYIFHGGRRHVRPYYFEFISHVNKRWTGKTIVDLFADEFKGRPRDYYVGAVKSGRIKVDGEIVPVSYIVKSSQKITHFLHRHEPPVMIDDVVILHQEPDVVTVCKPASVPVHPCGQYRKNTIVGILDAEHDLGTLFPIHRLDRLVSGLLIIARTAAKADFFRQQIEGGMVKKRYIAKVIGVFPEDEMIVDANINYNGSEGRSTAEDANSSGDDKKVKGKPACTKFTRIDTNGTHSLVSCEPVTGRTHQIRVHLQYTGHPIANDPLYLNQHIDNLETYIAKRIDAGERKIVSPDDYVYSSEDFSIDPMCTNCPKLIPQGYEEHDEALWLHCVQYCGTGWEYEWYQVDSLYSKILSFIDSKFYVIII
InterPro domains: - IPR020103: Pseudouridine synthase, catalytic domain superfamily (homologous_superfamily) [127-382]
- IPR006224: Pseudouridine synthase, RluA-like, conserved site (conserved_site) [183-197]
- IPR006145: Pseudouridine synthase, RsuA/RluA-like (domain) [144-299]
- IPR006225: Pseudouridine synthase, RluC/RluD (family) [69-317]
- IPR050188: RluA Pseudouridine Synthase (family) [46-384]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0009982 (pseudouridine synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0042445 (hormone metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0046483 (heterocycle metabolic process), GO:0010817 (regulation of hormone levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Lambda-carrageenase (EC 3.2.1.162) (Q0JRK4)
Organism: Pseudoalteromonas carrageenovora (Alteromonas carrageenovora)
Function: Hydrolyzes lambda-carrageenan with inversion of anomeric configuration. Does not hydrolyze iota- and kappa-carrageenans, agarose or porphyran.
Subcellular location: Secreted {ECO:0000269|PubMed:17269933}.
Sequence: MKIKILSAMVASSLLIGCVIPTVKASQSAIKSIETNRTITKVRTGMLSGGSSIITTSYEGTVAAYKFNGEKLWENELSGFMNHDIWVQDINGDGLVEIFAANADGNVYCINSDGSLKWTFGLNEVPMNSVTVISDADKKYVVAGGYDKNLYYISTNGELLKTIESGTYSEEGVFGDGVKPEARTHTVNFVRPVKSSDGTEKLVVLGTNNSLQSSGRFYIFEPFADLPSEKSRISIKKGIGDLRTVDFDNDGNDELTLGNSAQIGDAAISVMNLDDLSQKKSQINDIARRIDRFGYRVAQTEVVMNEGTPTYLTLFGSRILLTPESFDVNDSEILANKYSYYDMWKDKSSNKLVLASAQSGGSQVHIIDTSNPSWKSAYEELEPQGKLAAIQENTRAIERQLSNFQKPTRERAPLPVYFISESRNEIPTTIERSEFLYDSPVFLNYSTLPNVENWDRSEVLADNPKYRDKRDRRKNYTLSSEEMFNKLSAGYDNSDGISQWAGHGNDPYMISLATMKRIISSGDGKKTVNIYPEIEGHGDAFNKVLSDHFYPLAEFSSENNANLFMRNKHTFWQSTIYAPEWSELRSGRLADAFVPAMEETTDKSMEMSVAGRMGLWAAGSVDNWGERYARDNPSFDRLRQHSHQMVPNHALRQIIYKIASGARYINNFGFNQEYMSLAWELIGKGALYVPKREELLSLSPVHISMKEPDPIYRETSNNVKWTTFYDEEKDSIPYVFSRLNGTWPGAKTLPWDYSNYAADTKERRLDFIPKFPKGLVLITPVQQGKFKDEGTVRGTLADNMHPIYKDIMKEYITDGKNYYNPNGEQVMAADSVRYRQIKNKIEEKSNLLPMTVSGEAAWVVAQSAEKHLRLTLVDSGYLNPSNKVAKVKFNSVTPVAIVDVLSGETFSPDSNGVVEIPVLAGAFRFIDVKITEDLRNMQSSTL
InterPro domains: - IPR057420: Lambda-carrageenase, beta-propeller domain (domain) [53-367]
- IPR057421: Lambda-carrageenase, middle domain (domain) [453-823]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [24-220]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [49-539]
- IPR057422: Lambda-carrageenase, C-terminal domain (domain) [851-929]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0005976 (polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: PslL (Q9I1M8)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MLGSAFWLTLATLLGLCLGFAREWLLVASWGAGERSDAFLIALFLPEALRMSLAGGVLSAAALPLFLERQGERRLDWLAAILPALLGIAVALSLLLLAAAPWLVRLLGPGLAETASAQAAANLRVLAWCVPGLMLHALFSIPLQAAERFVLAGLGSLLFNLPPVLYLALHGQASQPEQLALACLLGSLLMPLVLLPSLWIEGWRPWHWRLSGVELGELGGRIAPLLLSNAASQGLALVERLVASLLGEGAVTWVNLARKLMNLPLIALMSLNQVLLGMMSRRQGGERLALLRRGLETASLLTLPAGVGLVAAAPGLVALLLPRQTAGSPLPALLAWFAVPLVFGAWNALLARYAYAAGDTRLPLRCELLGSALNAALLAVLPLIFGLPGIPLAALGGVLCTALLLMRRQALLGALPWARLWLLNALAMALAAGLLFRIDGIWLQLGLGTVAGCLALLGMALWLRPWRTD
InterPro domains: - IPR004268: Peptidoglycan biosynthesis protein MurJ (family) [30-443]
Interaction partners: - PslJ
- PslE
- PslH
- PslG
- PslF
- PslD
- PslI
- PslA
- dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase
- FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0005319 (lipid transporter activity), GO:0140303 (intramembrane lipid transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)
Protein: RE01730p (Secreted Wg-interacting molecule, isoform A) (Secreted Wg-interacting molecule, isoform B) (Q7JWQ7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSIKCVHLVGLLVLLMGGANALFDHTLKRDFPGPYCARENTCCKDRHDGCSVPISNTLCYCDEFCDRDDSSDCCPDYRSFCIGEVDPIISCEHNGVYFSKYNTTWDNCNECRCLEGGSVQCDEDLCLTDDAIVHSVNSIHRLGWSARKYDQWWGRKYSEGLKLRLGTKEPTYRVKAMTRLKNPTDGLPSSFNALDKWSSYISEVPDQGWCGASWVLSTTSVASDRFAIQSKGKENVQLSAQNILSCTRRQQGCEGGHLDAAWRYLHKKGVVDENCYPYTQHRDTCKIRHNSRSLRANGCQKPVNVDRDSLYTVGPAYSLNREADIMAEIFHSGPVQATMRVNRDFFAYSGGVYRETAANRKAPTGFHSVKLVGWGEEHNGEKYWIAANSWGSWWGEHGYFRILRGSNECGIEEYVLASWPYVYSYYNVKSA
InterPro domains: - IPR013128: Peptidase C1A (family) [196-412]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [383-402]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [187-419]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [128-420]
- IPR001212: Somatomedin B domain (domain) [38-86]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [365-375]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0017147 (Wnt-protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0045184 (establishment of protein localization), GO:0035592 (establishment of protein localization to extracellular region), GO:0030111 (regulation of Wnt signaling pathway), GO:0008104 (protein localization), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0071692 (protein localization to extracellular region), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0090263 (positive regulation of canonical Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Peptide YY (PYY) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3-36) (PYY-II)] (Q9EPS2)
Organism: Mus musculus (Mouse)
Function: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Subcellular location: Secreted.
Sequence: MVAVRRPWPVTVAMLLILLACLGALVDAYPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRYGKRDVPAALFSKLLFTDDSDSENLPFRPEGLDQW
InterPro domains: - IPR020392: Pancreatic hormone-like, conserved site (conserved_site) [48-64]
- IPR001955: Pancreatic hormone-like (family) [29-65]
Interaction partners: - Neuropeptide Y receptor type 2
- Pancreatic polypeptide prohormone
- Pro-neuropeptide Y
- Neuropeptide Y receptor type 1
- Neuropeptide Y receptor type 5
- Appetite-regulating hormone
- Pro-glucagon
- Pro-opiomelanocortin
- Neuropeptide Y receptor type 4
- Somatostatin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0003008 (system process), GO:0007154 (cell communication), GO:0008217 (regulation of blood pressure), GO:0003013 (circulatory system process), GO:0099536 (synaptic signaling), GO:0008015 (blood circulation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0005576 (extracellular region), GO:0005615 (extracellular space)