Protein: Mitochondrial distribution and morphology protein 34 (Q9UUC9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.
Subcellular location: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03105}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03105}. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. {ECO:0000255|HAMAP-Rule:MF_03105}.
Sequence: MSFRVKGWSDQFSESFYERATTLLTAALNKGTKHSMIADHITVKELDLGPQPPQLEILEVGDLAPDRFQGLFNLHYSGDASLVLQTKIRANPLSVQKSNVPSFSSRNTMLASRAPLTVPMFLRLSDLKLNGIVVLVFSKQKGITVVFRNDPLESVRVSSSFDSIPAIARFLQREIEVQLVSLFQEELPSIIYKMSRIWFAKSDSNLSFQKIPFTSPNQSHTSLANYNPDLLDGPPDYHESTKVDTHLPIKMGPLDVQTHPNIRSIASLALSRKALLPISSPSIPMSIYRSTPPDTIIQQLTTQSDDISAVSSPATQYSASDYLGSNDTTARPSIFGRSHGTSQFRRRERVKKRHVIKIHEASNKSASSSETFVGSKNVDLTESAFDSIPDTPTKIITNINKLKRNYTITNNWLENLQQKIPSEVDNGKVSGLQYSAFKLLMLQRLMAAKGSF
InterPro domains: - IPR027536: Mitochondrial distribution and morphology protein 34 (family) [1-444]
- IPR031468: Synaptotagmin-like mitochondrial-lipid-binding domain (domain) [1-196]
Interaction partners: - Mitochondrial distribution and morphology protein 12
- Mitochondrial distribution and morphology protein 10
- Maintenance of mitochondrial morphology protein 1
- Mitochondrial Rho GTPase 1
- Dynamin-related protein dnm1
- Probable mitochondrial import receptor subunit tom70
- Peroxisomal biogenesis factor 11
- Mitochondrial import receptor subunit tom7
- Mitochondrial import receptor subunit tom20
- Probable mitochondrial import receptor subunit tom40
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0022406 (membrane docking), GO:0071840 (cellular component organization or biogenesis), GO:0051640 (organelle localization), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0140056 (organelle localization by membrane tethering), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:1990456 (mitochondrion-endoplasmic reticulum membrane tethering), GO:0006996 (organelle organization), GO:0015914 (phospholipid transport), GO:0007005 (mitochondrion organization), GO:0015748 (organophosphate ester transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140534 (endoplasmic reticulum protein-containing complex), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:0044232 (organelle membrane contact site), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0098799 (outer mitochondrial membrane protein complex), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0005739 (mitochondrion), GO:0005783 (endoplasmic reticulum), GO:0044233 (mitochondria-associated endoplasmic reticulum membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031968 (organelle outer membrane), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)