Protein: Glyceraldehyde-3-phosphate dehydrogenase GAPCP2, chloroplastic (EC 1.2.1.12) (Glyceraldehyde-3-phosphate dehydrogenase of plastid 2) (NAD-dependent glyceraldehydephosphate dehydrogenase chloroplastic 2) (Q5E924)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in plastidial glycolytic pathway and plays a specific role in glycolytic energy production in non-green plastids and chloroplasts. Essential for breakdown of starch to form sucrose for export to non-photosynthetic tissues, and to generate primary metabolites for anabolic pathways such as fatty acid and amino acid synthesis. Plays an important role in plant development by providing substrates for the phosphorylated pathway of serine biosynthesis in roots. Plays a crucial role in pollen development. Functionally redundant with GAPCP1.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:19675149}.
Sequence: MALSSLLRSAATSAAAPRVELYPSSSYNHSQVTSSLGFSHSLTSSRFSGAAVSTGKYNAKRVQPIKATATEAPPAVHRSRSSGKTKVGINGFGRIGRLVLRIATFRDDIEVVAVNDPFIDAKYMAYMFKYDSTHGNYKGTINVIDDSTLEINGKQVKVVSKRDPAEIPWADLGAEYVVESSGVFTTVGQASSHLKGGAKKVIISAPSADAPMFVVGVNEKTYLPNMDIVSNASCTTNCLAPLAKVVHEEFGILEGLMTTVHATTATQKTVDGPSMKDWRGGRGASQNIIPSSTGAAKAVGKVLPELNGKLTGMAFRVPTPNVSVVDLTCRLEKDASYEDVKAAIKFASEGPLRGILGYTEEDVVSNDFLGDSRSSIFDANAGIGLSKSFMKLVSWYDNEWGYSNRVLDLIEHMALVAASR
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [85-255]
- IPR020828: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (domain) [85-234]
- IPR006424: Glyceraldehyde-3-phosphate dehydrogenase, type I (family) [86-408]
- IPR020831: Glyceraldehyde/Erythrose phosphate dehydrogenase family (family) [84-414]
- IPR020829: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (domain) [239-396]
- IPR020830: Glyceraldehyde 3-phosphate dehydrogenase, active site (active_site) [232-239]
Interaction partners: - Triosephosphate isomerase, cytosolic
- Triosephosphate isomerase, chloroplastic
- Phosphoribulokinase, chloroplastic
- Phosphoglycerate kinase 3, cytosolic
- Phosphoglycerate kinase 1, chloroplastic
- Phosphoglycerate kinase 2, chloroplastic
- Transketolase-2, chloroplastic
- Transketolase-1, chloroplastic
- Glucose-6-phosphate isomerase, cytosolic
- transaldolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0043169 (cation binding), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0046872 (metal ion binding), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0046914 (transition metal ion binding), GO:0043891 (glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity), GO:0004365 (glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity), GO:0005507 (copper ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0048878 (chemical homeostasis), GO:0007275 (multicellular organism development), GO:0019725 (cellular homeostasis), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0044238 (primary metabolic process), GO:0009791 (post-embryonic development), GO:0048658 (anther wall tapetum development), GO:0099402 (plant organ development), GO:0055082 (intracellular chemical homeostasis), GO:0090567 (reproductive shoot system development), GO:0048731 (system development), GO:0048608 (reproductive structure development), GO:0005975 (carbohydrate metabolic process), GO:0048437 (floral organ development), GO:0048438 (floral whorl development), GO:0048229 (gametophyte development), GO:0048653 (anther development), GO:0048443 (stamen development), GO:0048367 (shoot system development), GO:0061458 (reproductive system development), GO:0048364 (root development), GO:0009555 (pollen development), GO:0048466 (androecium development), GO:0048827 (phyllome development), GO:0080144 (intracellular amino acid homeostasis), GO:0009908 (flower development), GO:0022622 (root system development), GO:0080022 (primary root development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)