wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Target of rapamycin complex subunit lst8 (TORC subunit lst8) (P91040)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU369068}.
Sequence: MRFKKLKNRQIFIFFKKYFMTPEKSFETEKHFQNTNQVPTEAPPSFDPSPHALLVSASYDLTIRLWQLSTGKCIGTIPHNEGQVNALSLTSTGRDLAVGAWQKVRIYDVSSGKDPKATIELPKNVTVVGFEAAGRWMYTGGDDGVCRIWEMRNNQLVANRLLSFPGSTVTSIVPNTHQTHLFVSTNSAHVWVWDVVNHIFMRLPMPDDLKMQEFVQKLAVHPSGKKLTGITNKGRLLCWDLMTREVVESSAFDMFKSPIVPIEQDTGTYGCLRDEDKHYKMREGHGLSCRYSPDGKYIVASGSEKEVYVFNSETMEIKGSLQTECGWNWDAIFSSEGRYIFTGGNDNQVKIWDVENNKKVAQWDGHIKPLTAMCMNGPTPPP
InterPro domains: - IPR001680: WD40 repeat (repeat) [29-362]
- IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [54-354]
- IPR037588: Target of rapamycin complex subunit LST8 (family) [51-376]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [51-377]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [45-370]
- IPR019775: WD40 repeat, conserved site (conserved_site) [137-354]
Interaction partners: - RICTOR_N domain-containing protein
- Target of rapamycin homolog
- DAF-15
- Stress-activated map kinase-interacting protein 1 homolog
- GTP-binding protein
- GTP-binding protein Rheb homolog 1
- Ras-related GTP-binding protein C
- Autophagy-related protein 13 homolog
- Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4
- Serine/threonine-protein kinase smg-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0042330 (taxis), GO:0042221 (response to chemical), GO:0006935 (chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0016477 (cell migration), GO:0060326 (cell chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0005643 (nuclear pore), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0005634 (nucleus)
Protein: FAD/NAD(P)-binding domain-containing protein (Q38BX7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MYLPKQPVKVKESPFAVQKSRRFIAATGVAAFVTTAVASYFTLEKVRERQRRPDGVLLQHRNGKRVVIVGAGAAGCALAASITSACPDVHVTVIEREKKHVFHAVVPLAHVGHRSYDLNTTGGVDFLRSPATWNVTREAALVRGEVLRVDTTKNEVVVREDQEALTVTARAETSEQPSKNVLTWPMGLPSWLLGASLPPVNEHRYPYDVLVLACGAARSLGPLQKFLTGEQVDRYRIAVNPGITRDCLVHLYKGTVLHVKVPPTSFAEGATGVRSISTMRYVSRQHDGTFIGTVNTVWRYLFFFNKQKFCPYMAVTADRGPSDALPIEVNERVMDFWKQRSVNFMPCTYITHLDPRRSEATLYNYQTQQKQVVNYQLLLLDLPLVAPEFIRKSGLSRSEAAEGFAEVNPHTLQHVNHANIFAIGDCAALPTVKSYGAVFAQVPVVSHNVQQQLLHGAHGTGEMSNAAVRSRFARYDGYSSFHIVMTTWRAMWPEMTYGDWRDNLSFPTITDAPLSLTNNHIWDNLAWADVRGFLNAVYYQWFLYEVMFYFVFTRGAWYPPKWFSVPSFGDDGTML
InterPro domains: - IPR015904: Sulphide quinone-reductase (family) [33-567]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [64-496]
- IPR023753: FAD/NAD(P)-binding domain (domain) [65-219]
Interaction partners: - Stress-response A/B barrel domain-containing protein
- Rhodanese domain-containing protein
- Cytochrome oxidase assembly protein, putative
- Adrenodoxin, putative
- Electron transfer protein, putative
- ATP synthase subunit beta
- Mercaptopyruvate sulfurtransferase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0045333 (cellular respiration), GO:0009060 (aerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Group XIIB secretory phospholipase A2-like protein (Group XIII secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB) (Q99P27)
Organism: Mus musculus (Mouse)
Function: Not known; does not seem to have catalytic activity.
Subcellular location: Secreted.
Sequence: MKLLCGFFLLWLGLVGNLAQSDPSPKEEESYSDWGLRQLRGSFESVNSYVDSFMELLGGKNGVCQYRCRYGKAPMPRPGYKAQEPNGCSSYFLGIKVPGSMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRTLGFVSNVEAACDSLADTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL
InterPro domains: - IPR010711: Group XII secretory phospholipase A2 precursor (family) [7-195]
- IPR036444: Phospholipase A2 domain superfamily (homologous_superfamily) [59-174]
Interaction partners: - Group IIC secretory phospholipase A2
- Group 10 secretory phospholipase A2
- Group IIF secretory phospholipase A2
- Group IIE secretory phospholipase A2
- Group 3 secretory phospholipase A2
- Group IID secretory phospholipase A2
- Phospholipase A2
- Phospholipase A2 group V
- Cytochrome P450 2E1
- Polyunsaturated fatty acid lipoxygenase ALOX8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0031012 (extracellular matrix)
Protein: Putative ferric-chelate reductase 1 homolog (DmSDR2) (EC 1.-.-.-) (Q8MSU3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MMQALTMRSWLATLVTALLAVAIWPDPGQSLPQGAPETVCDTMLPFHSGGSVLPQNSVSPFSVETSSSTLGQGQTLRVDLTGVPAGLSFGGYMIQARNRNPPHQIIGQFGPARDGTIKLMNCENSVNNSATHSNAGPKQQVILEWQSPVDFLGQVVFNATIAQSYNEFWVGVPSQPVQIVRRDLSAAPPLPTQSPSAPAGTTRAPYVPPSYVAPNNVVAVSSDPIYNGCGQSKNCFGFPDGCVATKSCTSITVVTVRGDVFEFEIQSGKGTNAAYVAVGLSDDAKMGDDLTTECVPENGRVNLYSSLTSASPYSAVRSNVNQNSARLLDASIVDGVIYCRVQRDAVTNVQGRTFDLRNGKYHLLVASGSSLKENSVGYHDIGRLPSAQPINLAEVQDLSGSSRLLIQLHGAFMIAAWIGTTSLGIIFARYFKQTWVGSQSCGTDQWFAWHRLLMVTTWSLTVAAYVLIWVELKQAVWHAHSIIGLITVILCFIQPIGALFRPGPNDKKRPYFNWGHWLGGNLAHILGIVTIFFSVKLPKAELPEWMDWILVSFVVVHVLVHLIFSIGGMASERHLSQRANTFQMGDMSHHQQHAMRNGMSMERKMDAPYAGMRKGLLGVYGVVLILFVTVLILLVVLAPIEQFLGKS
InterPro domains: - IPR005018: DOMON domain (domain) [245-368]
- IPR002861: Reeler domain (domain) [25-195]
- IPR042307: Reeler domain superfamily (homologous_superfamily) [34-173]
- IPR051237: Ferric-chelate Reductase and Defense (family) [23-299]
- IPR006593: Cytochrome b561/ferric reductase transmembrane (domain) [372-570]
Interaction partners: - Large ribosomal subunit protein uL23m
- Fe2OG dioxygenase domain-containing protein
- Cytochrome c oxidase subunit 7C, mitochondrial
- Uncharacterized protein
- Uncharacterized protein, isoform B
- Large ribosomal subunit protein mL46
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein uL16m
- Large ribosomal subunit protein bL27m
- Small ribosomal subunit protein uS15m
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016722 (oxidoreductase activity, acting on metal ions), GO:0000293 (ferric-chelate reductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000139 (Golgi membrane)
Protein: Ribonuclease H2 subunit B (Ribonuclease HI subunit B) (A0A2R8Y6M7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKLGLPTGHFVMAAQRQKRGK
InterPro domains: - IPR041195: Rnh202, triple barrel domain (domain) [5-62]
- IPR019024: Ribonuclease H2 subunit B, wHTH domain (domain) [65-198]
- IPR040456: Ribonuclease H2 subunit B (family) [2-244]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0006325 (chromatin organization), GO:0008104 (protein localization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0033365 (protein localization to organelle), GO:0006334 (nucleosome assembly), GO:0051276 (chromosome organization), GO:0065004 (protein-DNA complex assembly), GO:0034502 (protein localization to chromosome), GO:0034728 (nucleosome organization), GO:0065004 (protein-DNA complex assembly), GO:0034508 (centromere complex assembly), GO:0071459 (protein localization to chromosome, centromeric region), GO:1903083 (protein localization to condensed chromosome), GO:0034501 (protein localization to kinetochore)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Max-like protein 1 (G5EEH5)
Organism: Caenorhabditis elegans
Function: Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mdl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging and may overlap with the insulin-like signaling pathway. Involved in promoting infection by the microsporidian pathogen N.parisii.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Sequence: MSDMSDLEDDQTGHCGSGEHSGPFDPKRHAREQHNALERRRRDNIKDMYTSLREVVPDANGERVQASRAVILKKAIESIEKGQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQSIIQ
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [29-88]
- IPR002418: Transcription regulator Myc (family) [22-78]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [25-114]
Interaction partners: - Mad-like protein 1
- Protein mxl-3
- Mitogen-activated protein kinase pmk-3
- Mitogen-activated protein kinase pmk-1
- Mitogen-activated protein kinase pmk-2
- Max-like protein homolog 2
- Protein WBSCR14 homolog
- 5'-tyrosyl-DNA phosphodiesterase
- BCL7-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0009791 (post-embryonic development), GO:0002164 (larval development), GO:0002119 (nematode larval development), GO:0040024 (dauer larval development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) (A0A384NL93)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004273}.
Sequence: MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLDPYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHYKLVPQQLAH
InterPro domains: - IPR036972: Cytochrome c oxidase, subunit Vb superfamily (homologous_superfamily) [32-129]
- IPR002124: Cytochrome c oxidase, subunit Vb (family) [1-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016675 (oxidoreductase activity, acting on a heme group of donors), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0004129 (cytochrome-c oxidase activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0015078 (proton transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0007585 (respiratory gaseous exchange by respiratory system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:0070069 (cytochrome complex), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0045277 (respiratory chain complex IV), GO:0019866 (organelle inner membrane), GO:0005751 (mitochondrial respiratory chain complex IV), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Interleukin-24 (IL-24) (Cytokine-like protein Mob-5) (Q9JI24)
Organism: Rattus norvegicus (Rat)
Function: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (By similarity). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q13007}.
Sequence: MQTSLRQQILPGLSLILLVLNQVPELQGQEFRFGPCQVTGVVLPELWEAFWTVKNTVKTQDELTSVRLLKPQVLQNVSDAESCYLAHSLLKFYLNTVFKNYHSKIVKFKVLKSFSTLANNFLVIMSKLQPSKDNAMLPISDSARRRFLLYHRTFKQLDIEVALAKAFGEVDILLAWMQNFYQL
InterPro domains: - IPR020423: Interleukin-10, conserved site (conserved_site) [78-98]
- IPR020444: Interleukin-24 (family) [53-178]
- IPR020443: Interleukin-10/19/20/24/26 (family) [8-182]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [28-183]
Interaction partners: - Interleukin 20 receptor subunit alpha
- Interleukin 22 receptor subunit alpha 1.
- Interleukin 20 receptor beta IL-20R2
- Interleukin family protein
- Interleukin family protein
- Interleukin 10 receptor subunit beta
- Interleukin-22 receptor subunit alpha-2
- Interleukin-10 receptor subunit alpha
- Interleukin 22
- Interleukin-23 receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0005126 (cytokine receptor binding), GO:0048018 (receptor ligand activity), GO:0005125 (cytokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Uncharacterized protein (Q38FB1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MPAKRRPVNIDNDEVIDFSTVGSSNMMKTPVPTTLLKSVVDLSSSEPPSSEAVTTASAMDMRLNAYTHRHAPRRRIGFCCNIAPQPIAVSGASALPKSTTAPTAASPSSAVSHGSNTTSMSADSKEQLDAFWREEAARREEKSKQVSRQQYEQQLCDLFRGAAPLVTPDPKPSGNEDGSRDMVEHRAYSLLEQFFTDGVPDVEPWDHWALTMPRYSRSNIAVGISLDRIYHPTLPPTHYSQLYLHAPNSEETVFRLPKTRDELRAERQERMRKAKEERDRAKKAAKQNEQLTVVESTGGGPAKVSITVSAKDRLSNRNLRYNLFGDSVLNPLGTDNKVFSQYQERFLEHQRRNHKRHVEAIPHQIEKRKQDIKRHSEERPVFRAYHIYPIYSSAHLGKLRNFANDGLLRGFVLWICRCHAIIVLTGGEVAVRHLERWILEKMKWESSETKAVRLMTCPLPDPATFSFVRQKSRKRDRQQQGDDGSRGREENQLEGDRHGTDGERAHVYMNFVESVQEGESFMCNMPAEGPWRDLTHVWRAAVGAVVAVGGGNNTESQSTV
InterPro domains: - IPR027104: U4/U6 small nuclear ribonucleoprotein Prp3 (family) [114-543]
- IPR010541: Small nuclear ribonucleoprotein Prp3, C-terminal domain (domain) [384-531]
- IPR013881: Pre-mRNA-splicing factor 3 domain (domain) [122-358]
Interaction partners: - PRP1 splicing factor N-terminal domain-containing protein
- PRP8 protein homologue
- Peptidyl-prolyl cis-trans isomerase
- Spliceosome-associated protein, putative
- U5 small nuclear ribonucleoprotein component, putative
- U6 snRNA-associated Sm-like protein LSm8p
- U6 snRNA-associated Sm-like protein LSm4
- Small nuclear ribonucleoprotein Sm D2
- H/ACA ribonucleoprotein complex subunit 2
- Sm protein G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000365 (mRNA trans splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)