Protein: Receptor homology region, transmembrane domain- and RING domain-containing protein 2 (AtRMR2) (ReMembR-H2 protein JR702) (Q8VZ14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the trafficking of vacuolar proteins. May function as a sorting receptor for protein trafficking to the protein storage vacuole (PSV) (By similarity).
Subcellular location: Protein storage vacuole membrane {ECO:0000269|PubMed:10953001}. Golgi apparatus membrane {ECO:0000305|PubMed:10953001}; Single-pass type I membrane protein {ECO:0000305|PubMed:10953001}. Note=Traffics through the Golgi apparatus before reaching the vacuolar compartment.
Sequence: MNRALVLLLYVCTVSCLASSKVILMRNNITLSFDDIEANFAPSVKGTGEIGVVYVAEPLDACQNLMNKPEQSSNETSPFVLIVRGGCSFEEKVRKAQRAGFKAAIIYDNEDRGTLIAMAGNSGGIRIHAVFVTKETGEVLKEYAGFPDTKVWLIPSFENSAWSIMAVSFISLLAMSAVLATCFFVRRHRIRRRTSRSSRVREFHGMSRRLVKAMPSLIFSSFHEDNTTAFTCAICLEDYTVGDKLRLLPCCHKFHAACVDSWLTSWRTFCPVCKRDARTSTGEPPASESTPLLSSAASSFTSSSLHSSVRSSALLIGPSLGSLPTSISFSPAYASSSYIRQSFQSSSNRRSPPISVSRSSVDLRQQAASPSPSPSQRSYISHMASPQSLGYPTISPFNTRYMSPYRPSPSNASPAMAGSSNYPLNPLRYSESAGTFSPYASANSLPDC
InterPro domains: - IPR051653: E3 ubiquitin-protein ligase and sorting receptor (family) [19-289]
- IPR046450: PA domain superfamily (homologous_superfamily) [31-162]
- IPR044744: ZNRF4 /RNF13/RNF167, PA domain (domain) [11-161]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [191-279]
- IPR003137: PA domain (domain) [52-140]
- IPR001841: Zinc finger, RING-type (domain) [231-274]
Interaction partners: - AT4G21215 protein
- Protein POLAR-like 1
- Vacuolar-sorting receptor 1
- Thiamine phosphate phosphatase-like protein
- non-specific serine/threonine protein kinase
- ARM repeat superfamily protein
- Alpha/beta-Hydrolases superfamily protein
- Phosphatidylglycerophosphate phosphatase 1, chloroplastic/mitochondrial
- ARM repeat superfamily protein
- Vesicle-associated protein 2-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005802 (trans-Golgi network), GO:0097708 (intracellular vesicle)