Protein: Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like) (Q8WW43)
Organism: Homo sapiens (Human)
Function: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR
InterPro domains: - IPR009294: Gamma-secretase subunit Aph-1 (family) [1-250]
Interaction partners: - Nicastrin
- Gamma-secretase subunit PEN-2
- Presenilin-2
- Presenilin-1
- Gamma-secretase subunit APH-1A
- Amyloid-beta precursor protein
- Transmembrane emp24 domain-containing protein 10
- Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 3
- Neurogenic locus notch homolog protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030234 (enzyme regulator activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0061134 (peptidase regulator activity), GO:0008047 (enzyme activator activity), GO:0016504 (peptidase activator activity), GO:0061135 (endopeptidase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0007267 (cell-cell signaling), GO:0006807 (nitrogen compound metabolic process), GO:0048583 (regulation of response to stimulus), GO:0071704 (organic substance metabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0003008 (system process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0099536 (synaptic signaling), GO:1901564 (organonitrogen compound metabolic process), GO:0007611 (learning or memory), GO:0019538 (protein metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0050877 (nervous system process), GO:0043603 (amide metabolic process), GO:0043170 (macromolecule metabolic process), GO:0001964 (startle response), GO:0032102 (negative regulation of response to external stimulus), GO:0007613 (memory), GO:0050905 (neuromuscular process), GO:0050890 (cognition), GO:0006518 (peptide metabolic process), GO:0006508 (proteolysis), GO:0099537 (trans-synaptic signaling), GO:0042982 (amyloid precursor protein metabolic process), GO:0050435 (amyloid-beta metabolic process), GO:0098916 (anterograde trans-synaptic signaling), GO:0042987 (amyloid precursor protein catabolic process), GO:0033619 (membrane protein proteolysis), GO:0007614 (short-term memory), GO:0007268 (chemical synaptic transmission), GO:0006509 (membrane protein ectodomain proteolysis), GO:0001963 (synaptic transmission, dopaminergic), GO:0035249 (synaptic transmission, glutamatergic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0098797 (plasma membrane protein complex), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0070765 (gamma-secretase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)