wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: mRNA degradation protein pet127, mitochondrial (O74832)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for the degradation of mRNA in mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Sequence: MLIYKKKNFGRRSVYNLKKCLHKGFQINSCNIKAADNVLHSKASAFEKVNVVDKESIGNLQHHLDTVLPKKKFQFLRDPKTNDYKWDEYLSKILPVDKFNFGLLSKFRPPSEDEQLQKVANSIGAEFVGSTSSLTGLMSQLHFFISKWKFPNFSDLSKGFYISPNERNFTRLCRSASSVHISYQNGLYCIDKDKSLTKEPSVNIILMNVGKSLETFFTVDKDQFLLYKKPPSSNGVLKPLKDVFQYGRCSSLLVRSQLDCYDKKIPESGVFDLKTRAVFGVRMNQTQPELFKSYKLTHYYGNRISFEREYFDLIRSAFMKYSLQARLGYMQGVFVAYHNTSDIFGFQYIPLVAMDRAIHGSSEIGEAEFNLNLQLLEKILQYATSIFPKRSFRVMLSTTEDVPNPPLKVYLEVADDKENRGFDLLDGQKNLEAKTVSPSNFCALEVCALQFVNGVHKSVVKHLDEKETWSIKYHFRKPRDQDNLLRNYIRLRDDIKRRESKISNPPESLLHDYYACSEQYYKRN
InterPro domains: - IPR013943: Mitochondrial protein Pet127 (family) [26-524]
Interaction partners: - ATP-dependent RNA helicase suv3, mitochondrial
- Exoribonuclease II, mitochondrial
- ATP synthase subunit a
- Uncharacterized exonuclease C637.09
- Ribonuclease Z 1
- Pentatricopeptide repeat-containing protein 5
- Probable oligoribonuclease
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004527 (exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0140053 (mitochondrial gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0000963 (mitochondrial RNA processing), GO:0000966 (RNA 5'-end processing), GO:0000959 (mitochondrial RNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65) (Q64375)
Organism: Rattus norvegicus (Rat)
Function: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q92791}.
Sequence: MARAAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLATAYGHALEQYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPATSQPRPAPGPDGDNEGDGEDWARELRLFGHVLERAACLRRCKRTLPAFQVPYPSRQLLRDFQNRLPYQYLHYAHFKANRLEKAVAAAYTFLQRNPKHELTAKYLNYYRGMLDIGDESLTDLEAQPYEAVFLQAVKLYNSGDFRSSTEHMERALADYMTVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCEANLTPNVGGFFVDKFVATMYHYLQFAYYKLNDVHQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEAVLYHNQTSELRELLDFTHMYLQSDDEMELEETESLPEPEKPLSDAEFEGEGDYEEGLYADWWQEPDAKGDEDEAEPEPELA
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [210-345]
- IPR056585: Leprecan-like alpha-helical domain (domain) [35-346]
- IPR052284: Collagen-modifying leprecan protein (family) [5-436]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: MecKel-Gruber Syndrome (MKS) homolog (C8JQP7)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MISNVRSSLVYQILLSLQKTLSIVYFLVIFILYFYKGAILPYPRYVRVMEFFVIIPFIPIEYLRINWGSRGNLLESTAFLALSTVLSIPIIIILVYLEFFQNYVLFIEEIFTYVMGFFVILETLLSLVLTITFSSSGQPASG
InterPro domains: - IPR019184: Uncharacterised protein family, transmembrane-17 (family) [3-137]
Interaction partners: - Meckelin
- C2 domain-containing protein
- B9 domain-containing protein 1
- MecKel-Gruber Syndrome
- NePHronoPhthisis
- TMEM
- ADP-ribosylation factor-like protein 6
- Intraflagellar transport protein 46 homolog
- Protein fantom
- B9 domain-containing protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly), GO:1905515 (non-motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0035869 (ciliary transition zone), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)
Protein: Syntaxin-11 (Q9D3G5)
Organism: Mus musculus (Mouse)
Function: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
Subcellular location: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Sequence: MKDRLAELQELSRSYDQQFPDGDNDFDAPREDIVFETDNILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKELSEQAEARHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDMSGEQIEDMFEQGKWDVFSENLLADLKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQEDTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN
InterPro domains: - IPR006011: Syntaxin, N-terminal domain (domain) [36-193]
- IPR042781: Syntaxin 11, SNARE motif (domain) [203-265]
- IPR045242: Syntaxin (family) [57-282]
- IPR000727: Target SNARE coiled-coil homology domain (domain) [199-266]
- IPR006012: Syntaxin/epimorphin, conserved site (conserved_site) [210-249]
- IPR010989: SNARE (homologous_superfamily) [39-259]
Interaction partners: - Synaptosomal-associated protein 23
- Syntaxin-binding protein 2
- Vesicle-associated membrane protein 8
- Protein unc-13 homolog D
- Vesicle-associated membrane protein 2
- Syntaxin-binding protein 5
- Syntaxin-19
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 4
- Syntaxin-12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0044706 (multi-multicellular organism process), GO:0007275 (multicellular organism development), GO:0009566 (fertilization), GO:0007566 (embryo implantation), GO:0007340 (acrosome reaction), GO:0044703 (multi-organism reproductive process), GO:0007565 (female pregnancy), GO:0030154 (cell differentiation), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0098857 (membrane microdomain), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0045121 (membrane raft), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005911 (cell-cell junction), GO:0097708 (intracellular vesicle)
Protein: Neuropeptide Y receptor type 4 (NPY4-R) (NPYR-D) (Pancreatic polypeptide receptor 1) (PP1) (Q61041)
Organism: Mus musculus (Mouse)
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP >> PYY >= NPY.
Subcellular location: Cell membrane {ECO:0000269|PubMed:8641440}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MNTSHFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFIITTYSIETILGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSIFQAYLGIVVIWFVSCFLSLPFLANSTLNDLFHYNHSKVVEFLEDKVVCFVSWSSDHHRLIYTTFLLLFQYCIPLAFILVCYIRIYQRLQRQKHVFHAHACSSRAGQMKRINSMLMTMVTAFAVLWLPLHVFNTLEDWYQEAIPACHGNLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIKALVLTCHCRSPRGESEHLPLSTVHTDLSKGSMRMGSKSNFI
InterPro domains: - IPR000611: Neuropeptide Y receptor family (family) [68-333]
- IPR001933: Neuropeptide Y4 receptor (family) [2-373]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [58-322]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [43-330]
Interaction partners: - Pro-neuropeptide Y
- Peptide YY
- Pancreatic polypeptide prohormone
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008188 (neuropeptide receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0003008 (system process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0007631 (feeding behavior), GO:0008217 (regulation of blood pressure), GO:0048638 (regulation of developmental growth), GO:0005996 (monosaccharide metabolic process), GO:0050877 (nervous system process), GO:0005975 (carbohydrate metabolic process), GO:0040014 (regulation of multicellular organism growth), GO:0003013 (circulatory system process), GO:0007626 (locomotory behavior), GO:0019318 (hexose metabolic process), GO:0008015 (blood circulation), GO:0007600 (sensory perception), GO:0006006 (glucose metabolic process), GO:0019233 (sensory perception of pain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: BBG-LP29 (Q15K32)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: TRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKICFA
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [111-224]
- IPR001478: PDZ domain (domain) [141-222]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0090130 (tissue migration), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0030707 (follicle cell of egg chamber development), GO:0007281 (germ cell development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0090132 (epithelium migration), GO:0007297 (follicle cell of egg chamber migration), GO:0016477 (cell migration), GO:0010631 (epithelial cell migration), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0048477 (oogenesis), GO:0007298 (border follicle cell migration), GO:0060429 (epithelium development), GO:0001667 (ameboidal-type cell migration), GO:0030855 (epithelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005911 (cell-cell junction), GO:0043231 (intracellular membrane-bounded organelle), GO:0043296 (apical junction complex), GO:0070160 (tight junction), GO:0005634 (nucleus), GO:0005918 (septate junction)
Protein: Transforming acidic coiled-coil containing protein 1 (E5RFM9)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MGGSHSQTPRGREPAGERHPRPTETASDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD
InterPro domains: - IPR039915: TACC family (family) [533-746]
- IPR007707: Transforming acidic coiled-coil-containing protein, C-terminal (domain) [542-741]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0005102 (signaling receptor binding), GO:0003713 (transcription coactivator activity), GO:0030374 (nuclear receptor coactivator activity), GO:0140297 (DNA-binding transcription factor binding), GO:0042975 (peroxisome proliferator activated receptor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0016922 (nuclear receptor binding), GO:0042974 (nuclear retinoic acid receptor binding), GO:0030331 (nuclear estrogen receptor binding), GO:0046966 (nuclear thyroid hormone receptor binding), GO:0035259 (nuclear glucocorticoid receptor binding), GO:0046965 (nuclear retinoid X receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0061351 (neural precursor cell proliferation), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0007405 (neuroblast proliferation), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: OmpA family protein (Q72C62)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Not known
Subcellular location: Cell outer membrane {ECO:0000256|ARBA:ARBA00004442}.
Sequence: MPESGETSDLEAYMKFARYLALLAALVFACASSALAASPEKVLVPKISSFDFFVDYSGSMAMKHAKLGKDKIVVAKELMTAINAKIPALGYKGGLHTFAPSSEVIAQGPWDRAGYEKGIKSLKSNFDIFGRLTPMSQGFEKALPYVQNMQRKAAVILISDGEANVGMDPVTAAKAVAALKDVCIHVISLADTAKGQATLDAISKLSPCSVSVNGADLLNNEKALDKFVRDVFYDEQAPKAAAAPMEEVIVLRNVQFALNSAKLDASATSILTEAARIIKANPGKKLLVAGHTCNLGTDAYNLKLSDARAKSVKDFLVKQGVEASRLDTFGFGESQPKYDNGTEQGRSMNRRVELSFR
InterPro domains: - IPR036737: OmpA-like domain superfamily (homologous_superfamily) [224-357]
- IPR006665: OmpA-like domain (domain) [244-357]
- IPR050330: Bacterial Outer Membrane Structural/Functional (family) [197-356]
- IPR006664: Outer membrane protein, bacterial (domain) [256-317]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [52-223]
Interaction partners: - Tol-Pal system protein TolB
- Desulfoferrodoxin
- WD40 domain protein beta Propeller
- DNA-binding protein HU
- Adenylylsulphate reductase, beta subunit
- Adenylyl-sulphate reductase, alpha subunit
- TPR domain protein
- Pyruvate:ferredoxin oxidoreductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044000 (movement in host), GO:0044409 (entry into host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042597 (periplasmic space)
Protein: Chitinase 12 (EC 3.2.1.14) (Q8MLW8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MTSFQYVFMIMIFLICGCIAKEYNVFCQYDLGSYYYKGRSQFFEWHLDSRLCTHLVLGSGIGVDGDSGELRITDKILLLEKDKLSSVKTMKWDSIKKVMFTIGGWEEDSSSFSRMVASPKKRDNFYSSMLEFMFRWGFDGVQIDWRYPTLLGGHPDDRQNFVILLEELGLIFRKNQLILMVAVLGRRDNRILESYNIPEIVNHSDFIHLMMHDEQDPYHLRLAYNAPLVGYEGSVTDSIMHWKRNGGAPEKLILGIPLFVRSFTMDRNQSTVGSACKGPGRQTKQSHRPGFMTYNEWCVQQSKWSRMFDQLAKVPYATRGDQWVSYENPRSIWAKMHLLQEHKLGGAMAWTIDVDDFRGRCGEQHGLLRVIFSALGDKNGLTTEKPTTEASGLCPHDGFSRDGWDCRLYHECRDGERIYYECLEGQYFDENQIVCRPAAEVKCDQNFVIWRPGMPVYSYDNMPLNLKIVE
InterPro domains: - IPR036508: Chitin binding domain superfamily (homologous_superfamily) [388-447]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [25-375]
- IPR050314: Glycosyl Hydrolase Family 18 (family) [21-373]
- IPR011583: Chitinase II/V-like, catalytic domain (domain) [29-355]
- IPR001223: Glycoside hydrolase family 18, catalytic domain (domain) [29-378]
- IPR002557: Chitin binding domain (domain) [391-445]
- IPR029070: Chitinase insertion domain superfamily (homologous_superfamily) [258-326]
Interaction partners: - N-acetyl-D-glucosamine kinase
- beta-N-acetylhexosaminidase
- beta-N-acetylhexosaminidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008061 (chitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0042303 (molting cycle), GO:0022404 (molting cycle process), GO:0006950 (response to stress), GO:0009611 (response to wounding), GO:0018990 (ecdysis, chitin-based cuticle), GO:0007591 (molting cycle, chitin-based cuticle), GO:0042060 (wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)