Protein: Cingulin (Q1L8T5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Note=Localizes to the apical junction complex composed of tight and adherens junctions
Subcellular location: Cell junction, tight junction
Sequence: MSSLSADRKPPLDYGVQIRFIKDLDDAGGGFPDKSRLANGVGGVSNGTSSPSKYGVAVRVQGISGQPYVVLQDGEKGDSYGVQLKTQPQIQSAPPVVSQTSPYNTLLLGQREGARTPQGSYNPTDQPSSPDEDFGSPLRRPPGDGQAGTQGEAEPRTTERFTPSALAPKLDKKDNDAFNEAGLRKVKQNGIGSSLNGTGLNGSFPPPSSAQDEDQAPAIDTKSLAPINKLISRFGGGGGGSGDILNSEAQTRPRLDNRVRSQSADALNKPSEEASSTSPTINPYAPNTSATVPKLNSTKPSSTGSLGRDATSVAKVAAIPNFKPLAFNQSPKLFAPKEAPPAVPKKPVTPDLIKSQTTSIENGNGEDDQTKQAIYNILKEGSIEKEEAIKRKASLIHERFCGVKAPQISVTDSNMKTELEQAFGRNTQLQQQLDKSRRELQENQDQMVELRMDREGAESRLRQQEDQLAQLQEELRRTLENSPQSDSMQLDLLTVQAELSESQLLRQKLEDTLRQRERELTALKGALKDEVASHDKEMEALREQFSQDMDALRHSMETVSQSQLEIEEERQKVNASILAMEEELEGYKEQSEQWKKQFSSANQELLKAQQGKRELEEKLLAVVKQTDETDSNSVMKELQQCRDSLKKAQSELEKQKAETLKKQEELKSATRASEKRETELKAEIDRLINQLKKEKEELSKAIEKTQQPLVSDQTKDPESNLELQEANARLRERIARMTRLHSSVPDSSSSDALEEENRSLKTQLEESRRAASRLGVEKEELNRRLEEREREREALRRGKSDLEEQKRLLDRSLDKINKEMESMMGDSRQSVQVLQSQLEEFRDRSRRELQDAQRLSKDRLVELQRAQALLKTTQEEVSRVKKELLSCTEERDSTQLDKELLSSRLKNMETELQTDRSSQTDRSREIRLLEDKVKTLEIELDEEKSGAELLNERITRCREQVDQLRSELMQERSARHDLEMDKSALERQIKELKSRIADMGTQSRPSAGVTMLENKVQELEDRLRSEEREKNTIQAAQRRLDRKLKDVTATLDQERNQHAEQRDQLSLRVKALKRQLDESEGEVERLEGVRRKVLRELEEQRELQAALQAKVNAMDNELRKIQQSRRSTLGSTLSSDEEDNYSDTKSITSILTDSPLQTTSC
InterPro domains: - IPR002928: Myosin tail (domain) [778-1118]
Interaction partners: - Rho guanine nucleotide exchange factor 2 isoform X1
- Rho guanine nucleotide exchange factor 2
- Rho guanine nucleotide exchange factor 18a isoform X1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0035295 (tube development), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0055006 (cardiac cell development), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0035051 (cardiocyte differentiation), GO:0097435 (supramolecular fiber organization), GO:0007507 (heart development), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0055003 (cardiac myofibril assembly), GO:0055002 (striated muscle cell development), GO:0055013 (cardiac muscle cell development), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005884 (actin filament), GO:0015629 (actin cytoskeleton)