Protein: Sodium/potassium-transporting ATPase subunit beta-2 (Protein nervana 2) (Sodium/potassium-dependent ATPase subunit beta-2) (Q24048)
Organism: Drosophila melanogaster (Fruit fly)
Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDPRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID
InterPro domains: - IPR038702: Sodium/potassium-transporting ATPase subunit beta superfamily (homologous_superfamily) [20-323]
- IPR000402: Sodium/potassium-transporting ATPase subunit beta (family) [18-323]
Interaction partners: - Sodium/potassium-transporting ATPase subunit alpha
- Multidrug resistance protein homolog 65
- Sodium/potassium-transporting ATPase subunit beta-1
- Neurexin-4
- Neuroglian
- Sodium/potassium-transporting ATPase subunit alpha
- GH05443p
- Uncharacterized protein, isoform A
- G-protein coupled receptor moody
- Lachesin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060590 (ATPase regulator activity), GO:0005515 (protein binding), GO:0140677 (molecular function activator activity), GO:0001671 (ATPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0032504 (multicellular organism reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0007276 (gamete generation), GO:0090068 (positive regulation of cell cycle process), GO:0140013 (meiotic nuclear division), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0045132 (meiotic chromosome segregation), GO:0007143 (female meiotic nuclear division), GO:0016321 (female meiosis chromosome segregation), GO:0045787 (positive regulation of cell cycle), GO:0010564 (regulation of cell cycle process), GO:0007140 (male meiotic nuclear division), GO:0045787 (positive regulation of cell cycle), GO:0051984 (positive regulation of chromosome segregation), GO:0098813 (nuclear chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:1901989 (positive regulation of cell cycle phase transition), GO:1901987 (regulation of cell cycle phase transition), GO:0045931 (positive regulation of mitotic cell cycle), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0048285 (organelle fission), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0005890 (sodium:potassium-exchanging ATPase complex), GO:0098533 (ATPase dependent transmembrane transport complex), GO:0090533 (cation-transporting ATPase complex)