Protein: COP9 signalosome complex subunit 6a (AtCSN6a) (Signalosome subunit 6a) (Q8W206)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex. Essential for the structural integrity of the CSN holocomplex.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Sequence: MAPSSSSGLTFKLHPLVIVNISDHYTRVKTQLNPPASICASGHGSNNGEAMFQQNPRVYGCVIGVQRGRTVEIFNSFELLYDPSTQTLDRSFLEKKQELYKKVFPDFYILGWYSTGSDAEESDMHIHKALMDINESPVYVLLNPAINHTQKDLPVTIYESELHVIDGIPQLIFAHTSYTIETVEAERISVDHVAHLKPSDGGSAATQLAAHLTGIHSAIKMLNSRIRVLYQNLAAMQKGDKSCDNSVLRQVSSLLRRLPAMESERFQDNFLMEYNDKLLITYLAMITNCSSNMNEMVDKFNTAYDRNTRRGGRTAFM
InterPro domains: - IPR033859: COP9 signalosome subunit 6 (family) [9-313]
- IPR000555: JAB1/MPN/MOV34 metalloenzyme domain (domain) [7-163]
- IPR037518: MPN domain (domain) [30-164]
- IPR024969: EIF3F/CSN6-like, C-terminal (domain) [184-298]
Interaction partners: - COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 1
- COP9 signalosome complex subunit 5b
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 5a
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 7
- COP9 signalosome complex-related / CSN complex-like protein
- NEDD8-like protein RUB3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044085 (cellular component biogenesis), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043933 (protein-containing complex organization), GO:0006508 (proteolysis), GO:0022607 (cellular component assembly), GO:0070646 (protein modification by small protein removal), GO:0065003 (protein-containing complex assembly), GO:0070647 (protein modification by small protein conjugation or removal), GO:0000338 (protein deneddylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0000502 (proteasome complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)