Protein: Leucine-rich repeat-containing G protein-coupled receptor 8 (Relaxin family peptide receptor 2) (Q5ECL0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MWLLLHVVLLMEVKDFTLAGSNMVAPLCPKGYFPCGNLTKCLPRAFHCDGVDDCGNGADEDNCGDTSGWTTIFGTVHGNVNKVTLTEECFLSRYPQHCYCRENELECVNADLKAVPKVSSNVTLLSLKKNKIHRLPVKVFSKYAELRKIFLQHNCITHISRRAFLGLHNLQILYLSHNCITSLRPGIFKDLHQLAWLILDDNPITRISQRSFTGLNSLFFLSMVSNRLEALPERLCAQMPQLNWVDLANNGIKFITNSTFLTCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNVIAKLPAHLFSDLHLLQKLNLSSNPLLYVHKNQFGSLKQLQSLDLERIEIPNINTGMFRPMKNLSHIYLKTFRYCSYVPHVRICMPSTDGISSSEDLLANSILRVSVWVIAFITCAGNFLVIAVRSLIKAENTTHAMSIKILCCADCLMGVYLFSVGVFDIKYRGQYQKYALLWMESVPCRLLGFLATLSTEVSVLLLTFLTLEKFLVIVFPFSNLRLGKRQTAVVLASIWVAGFLIAAVPFTSEDYFGNFYGKNGVCFPLHYDQAEDFGSRGYSLGIFLGVNLLAFLVITFSYVTMFCSIQKTALQTAEVRSHIGKEVAVANRFFFIVFSDAICWIPVFVVKILSLLQVEIPGTITSWIVVFFLPVNSALNPILYTLTTSLFKDKLKQLLHKHRRKSIFKVKKKSLSASIVWTDDSSLKLGVLNKIALGDSIMKPVSP
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [96-375]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [415-674]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [400-682]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [120-358]
- IPR001611: Leucine-rich repeat (repeat) [145-324]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [41-63]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [22-64]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [27-65]
- IPR008112: Relaxin receptor (family) [31-657]
Interaction partners: - Insulin-like 3
- Relaxin-3/INSL7 receptor 1 long form.
- Relaxin-3
- Prorelaxin 1
- Relaxin receptor 1
- Guanine nucleotide-binding protein G
- Neuroendocrine secretory protein 55
- Insulin-2
- Insulin-1
- Adhesion G protein-coupled receptor L3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0009967 (positive regulation of signal transduction), GO:0007281 (germ cell development), GO:0042127 (regulation of cell population proliferation), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009994 (oocyte differentiation), GO:0001556 (oocyte maturation), GO:0071695 (anatomical structure maturation), GO:0007292 (female gamete generation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0042981 (regulation of apoptotic process), GO:0043950 (positive regulation of cAMP-mediated signaling), GO:0043066 (negative regulation of apoptotic process), GO:0043949 (regulation of cAMP-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)