Protein: Bud site selection protein BUD4 (P53705)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis
Subcellular location: Cell surface. Bud neck. Spore, perispore. Note=Localizes to a ring at the mother-bud neck of yeast and pseudohyphal cells. Localizes to single or double rings distal to the junction of the mother cell and germ tube in hyphal cells. Requires septins for proper localization. Also found at the cell-surface of blastospores
Sequence: MQTSISTTTIEDHLHHYSPEESQKLLSRESSINTDLFKHENESVDLLLKEMNSTPSKLLPIDKHSHLQLQPQSSSASIFNSPTKPLNFPRTNSKPSLDPNSSSDTYTSEQDQEKGKEEKKDTAFQTSFDRNFDLDNSIDIQQTIQHQQQQPQQQQQLPQTDNNLIDEFSFQTPMTSTLDLTKQNPTVDKINENHAPTYINTSPNKSIMKKATPKASPKKVAFTATNPEIHHYPDNRVEEEDQSQQKEDSVEPPSIQHQWKDPSQFNYSDEDTNASVPPTPPLHTTKPTFAQLLNKNNEVNSEPEALTDMKLKHENFSNLSLDEKVNLYLSPTNNNNSKNVSDMDSHLQNLQDASKNKTNENIHNLSFALKAPKNDIENPLNSLTNADISLRSSGSSQSSLQSLRDDNRVLESTPGSPKKVNPGLSLNDGIKGFSDEVVESLLPRDLSRDKLETTKENDAPEHNNENFIDAKSTNTNKGQLLVSSDDHLDSFDRSYNHTEQSILNLLNSASQSQISLNALEKQKQIQEQEQTQAAEPEEETSFSDNIKVKQEPKSNLEFVKVTIKKEPVSATEIKAPKREFSSRILRIKNEDEIAEPADIHPKKENEANSHVEDTDALLKKALNDDEESDTTQNSTKMSIRFHIDSDWKLEDSNDGDREDNDDISRFEKSDILNDVSQTSDIIGDKYGNSSSEITTKTLAPPRSDNNDKENSKSFEDPANNESSQQQLEVPHTKEDDSILANSSNIAPPEELTLPVVEANDYSSFNDVTKTFDAYSSFEESLSREHETDSKPINFISIWHKQEKQKKHQIHKVPTKQIIASYQQYKNEQESRVTSDKVKIPNAIQSKKFKEVNVMSRRVVSPDMDDLNVSQFLPELSEDSGFKDLNFANYSNNTNRPRSFTPLSTKNVLSNIDNDPNVVEPPEPKSYAEIRNARRLSANKAAPNQAPPLPPQRQPSSTRSNSNKRVSRFRVPTFEIRRTSSALAPCDMYNDIFDDFGAGSKPTIKAEGMKTLPSMDKDDVKRILNAKKGVTQDEYINAKLVDQKPKKNSIVTDPEDRYEELQQTASIHNATIDSSIYGRPDSISTDMLPYLSDELKKPPTALLSADRLFMEQEVHPLRSNSVLVHPGAGAATNSSMLPEPDFELINSPTRNVSNNSDNVAISGNASTISFNQLDMNFDDQATIGQKIQEQPASKSANTVRGDDDGLASAPETPRTPTKKESISSKPAKLSSASPRKSPIKIGSPVRVIKKNGSIAGIEPIPKATHKPKKSFQGNEISNHKVRDGGISPSSGSEHQQHNPSMVSVPSQYTDATSTVPDENKDVQHKPREKQKQKHHHRHHHHKQKTDIPGVVDDEIPDVGLQERGKLFFRVLGIKNINLPDINTHKGRFTLTLDNGVHCVTTPEYNMDDHNVAIGKEFELTVADSLEFILTLKASYEKPRGTLVEVTEKKVVKSRNRLSRLFGSKDIITTTKFVPTEVKDTWANKFAPDGSFARCYIDLQQFEDQITGKALQFDLNCFNEWETMSNGNQPMKRGKPYKIAQLEVKMLYVPRSDPREILPTSIRSAYESINELNNEQNNYFEGYLHQEGGDCPIFKKRFFKLMGTSLLAHSEISHKTRAKINLSKVVDLIYVDKENIDRSNHRNFSDVLLLDHAFKIKFANGELIDFCAPNKHEMKIWIQNLQEIIYRNRFRRQPWVNLMLQQQQQQQSSQQ
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [1575-1686]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1561-1686]
- IPR052007: Bud site selection protein 4 (family) [42-1709]
Interaction partners: - Riboflavin synthase
- Cell division control protein 10
- Serine/threonine-protein kinase GIN4
- Septin
- DH domain-containing protein
- Septin
- 6,7-dimethyl-8-ribityllumazine synthase
- Axl2p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0033043 (regulation of organelle organization), GO:0031122 (cytoplasmic microtubule organization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007010 (cytoskeleton organization), GO:0033365 (protein localization to organelle), GO:0051493 (regulation of cytoskeleton organization), GO:0044380 (protein localization to cytoskeleton), GO:0072698 (protein localization to microtubule cytoskeleton), GO:1905508 (protein localization to microtubule organizing center), GO:0071539 (protein localization to centrosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005816 (spindle pole body), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0044732 (mitotic spindle pole body), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)