Protein: Rap guanine nucleotide exchange factor 1 (A0A8I5ZQV4)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKTPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTEREMEILNKTSVSPSTELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRAVSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQTPPQAACNLSPLPESMGESGPPFVGYSFQLPLGSCLQQDGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEDDLQNPAQPVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPPKQRQLQASYAASSFSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSEPPSGKDGHPRDLSVSSASGKDSRENGERSPKSLDALESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQCRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSVIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQVHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
InterPro domains: - IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [879-1123]
- IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [882-1111]
- IPR019804: Ras guanine-nucleotide exchange factor, conserved site (conserved_site) [1028-1057]
- IPR000651: Ras-like guanine nucleotide exchange factor, N-terminal (domain) [733-875]
- IPR008937: Ras-like guanine nucleotide exchange factor (family) [651-1113]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [714-1111]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0023051 (regulation of signaling), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0051049 (regulation of transport), GO:0050776 (regulation of immune response), GO:0010646 (regulation of cell communication), GO:0002697 (regulation of immune effector process), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0050766 (positive regulation of phagocytosis), GO:0009966 (regulation of signal transduction), GO:0050778 (positive regulation of immune response), GO:0010647 (positive regulation of cell communication), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0002699 (positive regulation of immune effector process), GO:0051128 (regulation of cellular component organization), GO:0050764 (regulation of phagocytosis), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0043410 (positive regulation of MAPK cascade), GO:0010976 (positive regulation of neuron projection development), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0046328 (regulation of JNK cascade), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0010975 (regulation of neuron projection development), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0045335 (phagocytic vesicle), GO:0030666 (endocytic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0030670 (phagocytic vesicle membrane)