wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: PhoP/PhoQ regulator MgrB (P64512)
Organism: Escherichia coli (strain K12)
Function: Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway; the 2 periplasmic Cys residues of MgrB are required for its action on PhoQ, and thus PhoP.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:20041203}; Single-pass membrane protein {ECO:0000305|PubMed:20041203}.
Sequence: MKKFRWVVLVVVVLACLLLWAQVFNMMCDQDVQFFSGICAINQFIPW
InterPro domains: - IPR020907: PhoP/PhoQ regulator MgrB (family) [1-47]
Interaction partners: - Sensor protein PhoQ
- Signal transduction protein PmrD
- Transcriptional regulatory protein PhoP
- Sensor protein BasS
- Transcriptional regulatory protein BasR
- Phosphoethanolamine transferase EptA
- Uncharacterized protein YebO
- Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
- Magnesium-transporting ATPase, P-type 1
- Two-component-system connector protein SafA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006521 (regulation of cellular amino acid metabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0033238 (regulation of amine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Pickpocket 29, isoform D (Pickpocket 29, isoform G) (A8DYP1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MWRKSVMNFRGFIRSFVENKGLLWIFVIGISGWSTVSILVLLKTRYETDSTTIGVSTAYSRWINTFPSIGICLTKSRAFNEFKAMMREYFQEDFAFSFTRMIYEYAFLNPNNIFTKEPTKNTSYPYNFNILDIRRKMFPTNCTECFKEIYFRGELVTDCEEIFKFHVTEMGYCFLANNLLDYDSIEEMPLRYSSLDNNRSLRLYMRSSVMYKYEMYVNSPEDLPFFNSLTYTISTDPTTYAFNVEEIHNHEGVIDEPISQRKCKFPSESSIEGFPYSFSACMSIIRSEFEMKTCDCSLFNPKDRNESLYCGLQHADCLIKEGFATRVKEYVGSSTVCLPSCVEQQISLVGVITENGTLYNNNTQITEIQIASPPTVRYERKVTQTKLDLIVGIGSVAGLFFGASLLNLLEIISYFIKKLKTMIFG
InterPro domains: - IPR001873: Epithelial sodium channel (family) [9-422]
Interaction partners: - Amiloride-sensitive Na+ channel
- Pickpocket protein 11
- Gustatory and pheromone receptor 32a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019098 (reproductive behavior), GO:0032504 (multicellular organism reproduction), GO:0019222 (regulation of metabolic process), GO:0007610 (behavior), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0002118 (aggressive behavior), GO:0007617 (mating behavior), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0002121 (inter-male aggressive behavior), GO:0007619 (courtship behavior), GO:0060179 (male mating behavior), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0016441 (post-transcriptional gene silencing), GO:0031047 (RNA-mediated gene silencing), GO:0008049 (male courtship behavior), GO:0010608 (post-transcriptional regulation of gene expression), GO:0035194 (RNA-mediated post-transcriptional gene silencing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Arginine/ornithine antiporter (Arginine-ornithine exchanger) (P18275)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway. Also mediates the proton motive force-driven uptake of arginine and ornithine, but the exchange is several orders of magnitude faster than the proton motive force-driven transport.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:1311296, ECO:0000269|PubMed:8449902}; Multi-pass membrane protein {ECO:0000269|PubMed:8449902}.
Sequence: MSQESSQKLRLGALTALVVGSMIGGGIFSLPQNMAASADVGAVLIGWAITAVGMLTLAFVFQTLANRKPELDGGVYAYAKAGFGDYMGFSSAWGYWISAWLGNVGYFVLLFSTLGYFFPIFGKGDTVAAIVCASVLLWALHFLVLRGIKEAAFINTVTTVAKVVPLFLFILICLFAFKLDIFTADIWGKSNPDLGSVMNQVRNMMLVTVWVFIGIEGASIFSSRAEKRSDVGKATVIGFITVLLLLVLVNVLSMGVMTQPELAKLQNPSMALVLEHVVGHWGAVLISVGLLISLLGALLSWVLLCAEIMFAAAKDHTMPEFLRRENANQVPANALWLTNICVQVFLVVVFFTSGDPDGMDPYTKMLLLATSMILIPYFWSAAYGLLLTLKGETYENDARERSKDLVIAGIAVAYAVWLLYAGGLKYLLLSALLYAPGAILFAKAKHEVGQPIFTGIEKLIFAAVVIGALVAAYGLYDGFLTL
InterPro domains: - IPR050367: Amino acid-polyamine-organocation superfamily (family) [1-447]
- IPR002293: Amino acid/polyamine transporter I (family) [13-421]
- IPR022461: Arginine/ornithine antiporter (family) [7-481]
- IPR004754: Amino acid antiporter (family) [1-482]
Interaction partners: - Arginine deiminase
- Carbamate kinase
- Ornithine carbamoyltransferase, catabolic
- 2-oxo-hept-3-ene-1,7-dioate hydratase
- Cytochrome c551 peroxidase
- Outer membrane protein OprG
- UspA domain-containing protein
- UspA domain-containing protein
- UspA domain-containing protein
- alcohol dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0072337 (modified amino acid transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) (allergen Aca s 4) (B0KZK1)
Organism: Acarus siro (Flour mite) (Tyroglyphus farinae)
Function: Not known
Subcellular location: Secreted {ECO:0000305|PubMed:22292590}.
Sequence: MAHLLLAVVAITLALSQSVFGGSPYSNPHFTGSRSVITHLMQWKFDDIAAECERFLGPKGYGGIQLSPVNEHAVLGNRPWYELYQPVGYKIQSRSGNEEQFKGMVQRCNKVGVRIYVDIVMNHMSGAQEGHGNCWFKLQWHHDVSRCSLLVPNDFHGRESCHTDNMDIKNYDNPEEARNCRLSGLRDLKQSSEYVRQKQADFLNHLIDLGVAGSRSDASKHMWPGDLEAIYGKLHNLNTAYFPANSRPFIYHEVIYYGGDGIKSSDYTKLGRAIEFHFYRDIANVVRRHNQLKTVKNFGQPWGMVPSDDALVMVDSHDLQRFHTGQVGVNINYFESRLLKVATAFMLAWPYGVPRVMSSYHWDQKIEDGKDKNDWIGPPSDGSGNILSVTPQPDDTCNKEWICEHRWRQIYNMVHFRNVAGNEAVSHWWDNGDYQIAFGRGSKAFIAINLQDGQGLNRKLATGLPQGTYCDLVTGNLAGGKCTGGTVTVDGSGNADINIAKTAEDPFVAIHVEAKLH
InterPro domains: - IPR006048: Alpha-amylase/branching enzyme, C-terminal all beta (domain) [429-513]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [28-418]
- IPR006046: Alpha amylase (family) [80-320]
- IPR006047: Glycosyl hydrolase family 13, catalytic domain (domain) [35-417]
- IPR013780: Glycosyl hydrolase, all-beta (homologous_superfamily) [423-517]
- IPR031319: Alpha-amylase, C-terminal domain (domain) [426-515]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0016160 (amylase activity), GO:0004556 (alpha-amylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0005975 (carbohydrate metabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009313 (oligosaccharide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Large ribosomal subunit protein mL54 (39S ribosomal protein L54, mitochondrial) (L54mt) (MRP-L54) (Q3MHJ5)
Organism: Bos taurus (Bovine)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11551941}.
Sequence: MAARRLFGATGSWARWRAWELPDPAGSVRLHVRDYAKRPVFKGGKGAKGAAVGETLKDPEVCTDPVQLTTHPMGVNIYKEGQDVVLKPDSEYPEWLFQMNVGPPKKLEELDPETREYWRLLRKHNIWRHNRLSKNQKF
InterPro domains: - IPR013870: Large ribosomal subunit protein mL54 (family) [1-135]
Interaction partners: - Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL2m
- Small ribosomal subunit protein mS22
- Large ribosomal subunit protein mL46
- Uncharacterized protein.
- Large ribosomal subunit protein uL10m
- Large ribosomal subunit protein uL14m
- Large ribosomal subunit protein mL62
- Small ribosomal subunit protein uS9m
- MRPL41 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0140053 (mitochondrial gene expression), GO:0043043 (peptide biosynthetic process), GO:0032543 (mitochondrial translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) (Q925B0)
Organism: Mus musculus (Mouse)
Function: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity). {ECO:0000250}.
Sequence: MATGGYRSGGSTTTDFLEEWKAKREKMRAKQNPAGPGSSGGDPAAKSPAGSLTPTAVAGTSELNHGPAGAAAPAAPAPGALNCAHGSSTLPRAAPGSRRAEDECPSAAAASGAPGSRGDEEEPDSAREKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAATLPDPGTSYLPQDPSRTVPGRYKSTTSAPEDEISNRYPRTDRSGFSRHNRDANAPASFSSSSTLEKRIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR
InterPro domains: - IPR026117: Prostate apoptosis response 4 (family) [1-332]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019900 (kinase binding), GO:0019902 (phosphatase binding), GO:0003779 (actin binding), GO:0019901 (protein kinase binding), GO:0019903 (protein phosphatase binding), GO:0005080 (protein kinase C binding), GO:0008157 (protein phosphatase 1 binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0003008 (system process), GO:0003013 (circulatory system process), GO:0043114 (regulation of vascular permeability), GO:0008015 (blood circulation), GO:0003018 (vascular process in circulatory system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005634 (nucleus), GO:0015629 (actin cytoskeleton)
Protein: Kanadaptin (O54716)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLGEDSDEEEEANTTEGKSSRSGQDDELGCTWGMGEDAVEDEAEENPIALDFQQDREAFYIKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMVQCSLEACRVLDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLVEKKRLNRMKKAGKLDEKPETFESLVAKLNDAERELAEISERLKASSKVLSEPSSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKLVKPAEIPELKKTELQTTNAENKTKKLALPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPALMQMKDEPEVEEEEEEEEEEEEKVKEEHEERVEDGGVRLLQEPELELEAAVEHPSAPSEPSCSKETKSHAAPANEYKQDRDEPKKKKSPGPGKFPPILSSKYREDDPDYCIWVPREGQSGDGRTHLNDKYGY
InterPro domains: - IPR014720: Double-stranded RNA-binding domain (domain) [108-176]
- IPR050923: Cellular Process Regulator and RNA Processing Protein (family) [1-322]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0019222 (regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0035196 (miRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Transducin/WD40 repeat-like superfamily protein (Q9M1E5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MARPRRRNTEIGDGFTEIFNREIGFSHPITISRRISASEGRVKKLDLYGKLNGHEGCVNAVEFNSTGDVLVSGSDDRQIMLWNWLSGSRKLSYPSGHCENVFQTKFIPFTDDRTIITSGADGQVRLGQILENGKVETKRLGRHHGRVYKLAVLPGDPNVFYSCGEDGFVQHFDIRSNSATMVLYSSPFTQGCRRHHSSSRIRLNSIAIDPRNSYYLAVGGSDEYARVYDTRRVQLAPVCRHVLPDAPVNTFCPRHLRETNSVHITGLAYSKAGELLVSYNDELIYLFEKNMGYGSSPVSVSPEKLQEMEEPQVYIGHRNAQTVKGVNFFGPNDEYVTSGSDCGHIFIWKKKGGKLVRAMVGDRRVVNQLESHPHIPLLASCGIEKSVKLWTPMSNDVLSLPEKIDKVMELNRVGREDQSRVTLTPDVIMHVLRLQRRQTSAFTERRYVSTDIGSDEGNDARFIASLVANDDESSDRECTVS
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [36-392]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [43-390]
- IPR001680: WD40 repeat (repeat) [44-391]
- IPR045151: DDB1- and CUL4-associated factor 8-like (family) [17-458]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:1901700 (response to oxygen-containing compound), GO:0010648 (negative regulation of cell communication), GO:1905957 (regulation of cellular response to alcohol), GO:1901420 (negative regulation of response to alcohol), GO:0010646 (regulation of cell communication), GO:0010033 (response to organic substance), GO:1901419 (regulation of response to alcohol), GO:0009966 (regulation of signal transduction), GO:0009788 (negative regulation of abscisic acid-activated signaling pathway), GO:0009743 (response to carbohydrate), GO:0009787 (regulation of abscisic acid-activated signaling pathway), GO:0034285 (response to disaccharide), GO:0009744 (response to sucrose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0080008 (Cul4-RING E3 ubiquitin ligase complex)
Protein: Casein kinase I homolog 1 (EC 2.7.11.1) (P40233)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.
Subcellular location: Cytoplasm.
Sequence: MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFGQEGLHNILVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLERLNTTEDENFDWNLLNNGKGWQSLKSRNAETENQRSSKPPAPKLESKSPALQNHASTQNVVSKRSDYEKPFAEPHLNSASDSAEPNQNSLPNPPTETKATTTVPDRSGLATNQPAPVDVHDSSEERVTREQVQNATKETEAPKKKKSFWASILSCCSGSNEDT
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [8-296]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [127-139]
- IPR050235: Casein Kinase 1 Ser/Thr Protein Kinase (family) [16-345]
- IPR017441: Protein kinase, ATP binding site (binding_site) [18-41]
- IPR000719: Protein kinase domain (domain) [12-296]
Interaction partners: - Casein kinase I homolog 3
- Pheromone P-factor receptor
- Casein kinase I homolog 2
- Pheromone M-factor receptor
- Meiotic recombination protein rec8
- Meiotic recombination protein rec11
- Separin
- Linear element protein rec10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0032879 (regulation of localization), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0032878 (regulation of establishment or maintenance of cell polarity), GO:0032880 (regulation of protein localization), GO:2000114 (regulation of establishment of cell polarity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0032153 (cell division site), GO:0051286 (cell tip)