Protein: Exocyst complex component EXO70B2 (AtExo70b2) (Exocyst subunit Exo70 family protein B2) (Q9LMJ4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of an exocyst subcomplex specifically involved in autophagy-related, Golgi-independent membrane traffic to the vacuole. Regulates autophagosome formation and autophagy-related Golgi-independent import into the vacuole (By similarity). Positive regulator of defense responses to pathogenic bacteria (e.g. P.syringae pv. maculicola), to the biotrophic oomycete H.arabidopsidis and to fungi (e.g. B.graminis hordei), especially in cell wall apposition formation related to plant defense. Required for both immediate and later responses triggered by pathogen-associated molecular patterns (PAMPs). Positive regulator of abscisic acid (ABA)-independent mannitol (drought)-promoted stomatal closure.
Subcellular location: Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9FGH9}. Cytoplasm {ECO:0000269|PubMed:19895414, ECO:0000269|PubMed:21193573, ECO:0000269|PubMed:21199889}. Nucleus {ECO:0000269|PubMed:19895414, ECO:0000269|PubMed:21199889}. Note=In the cytoplasm, localized in a peri-nuclear pattern. {ECO:0000269|PubMed:21199889}.
Sequence: MAEAGDENLYAAARDIARALGKDPSAAGDILQILSGYGASGNRGGDPRPTPSRGGSNVNFDRALTSLERQISSYIVEDRPIWSDPVDSRTFLDSVDELLAIAGDLRSMAGDKSVAVCQSRADELIQQVMFRLQEEFGFVMDRAPDSFDSDDEFPGEEDNDTSDGVIVARPITDYKIVIEALQSSVIGDLNAIAVRMVAGGFAKECSRVYSSRRREFLEESLSRLHLRGLSMEEVQESPWQDLEDEIDRWIKAVTLIFHVFFPSERLLCDRVFSDLPVSSVTDLSFMEVCRGTTTQLLNFADAIALGSRLPERLFKVVDLYEAMQDLIPKMETLFSDRYCSPLRHEALAIHKRLGEAIRGIFMELENLIRRDPPKTAFPGGGIHPITRYVMNYLRAACKSRQSLEQILDQTGNETGSDTRPLSVQIIWVLELLESNLEGKKRTYRDPSLCFLFMMNNDKYILDKAKDNELGLVLGEDWIVKHAAKLRQYHSNYRRSSWNQVVGLLRTDGPYPKLVENLRLFKSQFDEVCKVQSQWVVSDGQLREELRSSVAGIVSPAYSNFIRRLKESPEINGRRGEPFIPYTVEDVEFIIKRLFKESSS
InterPro domains: - IPR004140: Exocyst complex component Exo70 (family) [62-595]
- IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [82-594]
- IPR046364: Exocyst complex subunit Exo70, C-terminal (domain) [248-591]
Interaction partners: - Exocyst complex component SEC6
- Exocyst complex component SEC5A
- Exocyst complex component SEC8
- Exocyst complex component SEC3A
- E3 ubiquitin-protein ligase PUB22
- SNAP25 homologous protein SNAP33
- Exocyst complex component SEC15B
- Exocyst complex component SEC10a
- Exocyst complex component EXO84B
- Exocyst complex component SEC5B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0001101 (response to acid chemical), GO:0009967 (positive regulation of signal transduction), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0043207 (response to external biotic stimulus), GO:0033037 (polysaccharide localization), GO:0010646 (regulation of cell communication), GO:0010119 (regulation of stomatal movement), GO:1902074 (response to salt), GO:0009617 (response to bacterium), GO:1901419 (regulation of response to alcohol), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0010647 (positive regulation of cell communication), GO:1901700 (response to oxygen-containing compound), GO:1905957 (regulation of cellular response to alcohol), GO:0010033 (response to organic substance), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0090333 (regulation of stomatal closure), GO:0009743 (response to carbohydrate), GO:0052545 (callose localization), GO:0009787 (regulation of abscisic acid-activated signaling pathway), GO:0009789 (positive regulation of abscisic acid-activated signaling pathway), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium), GO:0052542 (defense response by callose deposition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0099023 (vesicle tethering complex), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0000145 (exocyst), GO:0005938 (cell cortex), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)