Protein: Ras-interacting protein RIP3 (Ras-interacting protein A) (Q9Y0C9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation.
Sequence: MSVYCELVDVVQQIRYKTQIFYETFKRDSIAEQIYNFSNESTSEIDPDIPFSKSLDKDYSLLYRPVSTSNNNATSGNSTPPNNAISPNQQQQQQQQAQQQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQQQQQQAQQQQQQAQQQAQVQAQQQQQKPTTATTASTVTTTPQQQPSPNNTTSSCTSSSSGSSSGTTNTTSNTTTSTNTSTVTSATNSSTISSLTSTNASTSSAYSTDQQKPNQPPQQPQNISQPQNISQQQNTNNVQQNNQQQQQQQQQQQQQQTSTSPKKCKIVTFTGTSVKLNSKTLQKSDKTSEKENKQQQPDSSKTQQQQQAQQQQSQQQQQAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPVFIFVKEKVNKVNHDLPITPPPSLLTRLVKPNSEEAEYGDIVPPPGMGLTLSIHTGNTGAGQLKVRVIEKATIIQTIFATLKLHHNNGGTGLIPDPKAYNLRIADSNGRIDQDFPPLDPNQYITKFKDEVLVLCPNPKFDLKKSSSSLSISGGVPQQNNNNSVNSNSSNNSNSSNNNMKSSGFQPQQSQQQQQQTQQTQQTQQQAQQAPQQQQSQQQQQQQQQHPQQIQQQLSSNQLQPDQVGGGGGGGGGNFHRTHHRNVSSGPDAPLVVKITLPDSSITKVVFQKTMLLKDLLESTCKKRKLLISDHYFTLENGQTCNGTLPMEKLGGADLILVSRRPIEQMTALSPTDTDSTGSSSDLQQDIFWYDALAWQYKTYEVTKTKKYGPKQDRIIGIDRERVTNMSPKDTETKRPARLIKDISKVALLEKPKYFTIEYNDGKSYIYEAKTTSLANNYLCK
InterPro domains: - IPR031567: Sin1, middle CRIM domain (domain) [441-515]
- IPR008828: TORC2 component Sin1/Avo1 (family) [1-559]
- IPR003116: Raf-like Ras-binding (domain) [650-695]
Interaction partners: - Protein LST8 homolog
- Protein pianissimo A
- DNA-directed RNA polymerase I subunit rpa2
- DNA-directed RNA polymerase II subunit rpb4
- DNA-directed RNA polymerases I and III subunit rpac1
- DNA-directed RNA polymerase III subunit rpc2
- Nucleolar protein 56
- DNA-directed RNA polymerase II subunit rpb2
- DNA-directed RNA polymerase II subunit rpb3
- DNA-directed RNA polymerases I, II, and III subunit rpabc1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0008047 (enzyme activator activity), GO:0005543 (phospholipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0099120 (socially cooperative development), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0031152 (aggregation involved in sorocarp development), GO:0033554 (cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0031668 (cellular response to extracellular stimulus), GO:0006935 (chemotaxis), GO:0071496 (cellular response to external stimulus), GO:0030587 (sorocarp development), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0043327 (chemotaxis to cAMP), GO:0031669 (cellular response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0140535 (intracellular protein-containing complex), GO:0038201 (TOR complex), GO:0031932 (TORC2 complex)