Protein: Fructose-bisphosphate aldolase 2, chloroplastic (AtFBA2) (EC 4.1.2.13) (Q944G9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a key role in glycolysis and gluconeogenesis.
Subcellular location: Plastid, chloroplast, plastoglobule {ECO:0000269|PubMed:16414959, ECO:0000269|PubMed:16461379}. Plastid, chloroplast stroma {ECO:0000269|PubMed:16414959}.
Sequence: MASTSLLKASPVLDKSEWVKGQSVLFRQPSSASVVLRNRATSLTVRAASSYADELVKTAKTIASPGRGILAMDESNATCGKRLDSIGLENTEANRQAFRTLLVSAPGLGQYVSGAILFEETLYQSTTEGKKMVDVLVEQNIVPGIKVDKGLVPLVGSNNESWCQGLDGLSSRTAAYYQQGARFAKWRTVVSIPNGPSALAVKEAAWGLARYAAISQDSGLVPIVEPEILLDGEHDIDRTYDVAEKVWAEVFFYLAQNNVMFEGILLKPSMVTPGAESKDRATPEQVAAYTLKLLRNRVPPAVPGIMFLSGGQSEVEATLNLNAMNQAPNPWHVSFSYARALQNTCLKTWGGRPENVNAAQTTLLARAKANSLAQLGKYTGEGESEEAKEGMFVKGYTY
InterPro domains: - IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [32-397]
- IPR029768: Fructose-bisphosphate aldolase class-I active site (conserved_site) [259-269]
- IPR000741: Fructose-bisphosphate aldolase, class-I (family) [51-398]
Interaction partners: - Sedoheptulose-1,7-bisphosphatase, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPB, chloroplastic
- Transketolase-1, chloroplastic
- Triosephosphate isomerase, chloroplastic
- Triosephosphate isomerase, cytosolic
- Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic
- Transketolase-2, chloroplastic
- Fructose-1,6-bisphosphatase 1, chloroplastic
- Glyceraldehyde-3-phosphate dehydrogenase GAPA2, chloroplastic
- NADP-dependent glyceraldehyde-3-phosphate dehydrogenase])
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0003676 (nucleic acid binding), GO:0043177 (organic acid binding), GO:1901149 (salicylic acid binding), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0016832 (aldehyde-lyase activity), GO:0003723 (RNA binding), GO:0031406 (carboxylic acid binding), GO:0046872 (metal ion binding), GO:0003729 (mRNA binding), GO:0046914 (transition metal ion binding), GO:0004332 (fructose-bisphosphate aldolase activity), GO:0033293 (monocarboxylic acid binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0070482 (response to oxygen levels), GO:0019637 (organophosphate metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0071456 (cellular response to hypoxia), GO:0006753 (nucleoside phosphate metabolic process), GO:0019318 (hexose metabolic process), GO:0071453 (cellular response to oxygen levels), GO:0006757 (ATP generation from ADP), GO:0043436 (oxoacid metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0036293 (response to decreased oxygen levels), GO:0016052 (carbohydrate catabolic process), GO:0006006 (glucose metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006096 (glycolytic process), GO:0019319 (hexose biosynthetic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0016310 (phosphorylation), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0036294 (cellular response to decreased oxygen levels), GO:0006163 (purine nucleotide metabolic process), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0006094 (gluconeogenesis), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0046031 (ADP metabolic process), GO:0006090 (pyruvate metabolic process), GO:0046034 (ATP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0010287 (plastoglobule), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031977 (thylakoid lumen), GO:0005576 (extracellular region), GO:0031967 (organelle envelope), GO:0048046 (apoplast), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0009941 (chloroplast envelope), GO:0009579 (thylakoid), GO:0005840 (ribosome), GO:0009534 (chloroplast thylakoid)