Protein: Secreted aspartic protease 3 (ACP 3) (Aspartate protease 3) (EC 3.4.23.24) (Candidapepsin-3) (P0CY29)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P0CY27}.
Sequence: MFLKNIFIALAIALLADATPTTFNNSPGFVALNFDVIKTHKNVTGPQGEINTNVNVKRQTVPVKLINEQVSYASDITVGSNKQKLTVVIDTGSSDLWVPDSQVSCQAGQGQDPNFCKNEGTYSPSSSSSSQNLNSPFSIEYGDGTTSQGTWYKDTIGFGGISITKQQFADVTSTSVDQGILGIGYKTHEAEGNYDNVPVTLKNQGIISKNAYSLYLNSRQATSGQIIFGGVDNAKYSGTLIALPVTSDNELRIHLNTVKVAGQSINADVDVLLDSGTTITYLQQGVADQVISAFNGQETYDANGNLFYLVDCNLSGSVDFAFDKNAKISVPASEFTAPLYTEDGQVYDQCQLLFGTSDYNILGDNFLRSAYIVYDLDDNEISLAQVKYTTASNIAALT
InterPro domains: - IPR033121: Peptidase family A1 domain (domain) [71-386]
- IPR001461: Aspartic peptidase A1 (family) [55-384]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [59-398]
- IPR001969: Aspartic peptidase, active site (active_site) [87-282]
- IPR033876: Secreted aspartic endopeptidase (domain) [70-386]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0070001 (aspartic-type peptidase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044068 (modulation by symbiont of host cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0035821 (modulation of process of another organism), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009056 (catabolic process), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0044003 (modulation by symbiont of host process), GO:0009966 (regulation of signal transduction), GO:0075136 (response to host), GO:0031349 (positive regulation of defense response), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0031347 (regulation of defense response), GO:0009057 (macromolecule catabolic process), GO:0052200 (response to host defenses), GO:0044406 (adhesion of symbiont to host), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0006518 (peptide metabolic process), GO:0030163 (protein catabolic process), GO:0051604 (protein maturation), GO:0052031 (modulation by symbiont of host defense response), GO:0010467 (gene expression), GO:1902531 (regulation of intracellular signal transduction), GO:0044416 (induction by symbiont of host defense response), GO:0050848 (regulation of calcium-mediated signaling), GO:0052572 (response to host immune response), GO:0006465 (signal peptide processing), GO:0016485 (protein processing), GO:0052553 (modulation by symbiont of host immune response), GO:0052559 (induction by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)