wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Dimethylallyl tryptophan synthase (Q2UG12)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Not known
Sequence: MEISKKAATLLPKPFYVLSQALNLSNKDHTKWWYSTAPMFATMMAGAGYDVHAQYKFLCIHREVIIPALGPYPEKGQPMHWKSHLTRFGLPFELSFNYSKSLLRFAFEPLGSLTGTKDDPFNTQAIRPVLQDLKAMVPGLDLEWFDHFTKALVVSEEEARTLLDRDIEIPVFKTQNKLAADLEPSGDIVLKTYIYPRIKSIATGTPKERLMFDAIKAADKFGKVATPLAILEEFIAERAPTLLGHFLSCDLVKPSESRIKVYCMERQLDLASIEGIWTLNGRRNDPETLDGLDALRELWQLLPVTEGLCPLPNCFYEPGTSPQEQLPFIINFTLSPKSALPEPQIYFPAFGQNDKTIAEGLATFFESRGWGGLAKSYPADLASYYPDVDLQTANHLQAWISFSYKGKKPYMSVYLHTFEAFSAAAQEVAMCHDGHNP
InterPro domains: - IPR012148: Aromatic prenyltransferase DMATS-type, fungi (family) [5-434]
- IPR017795: Aromatic prenyltransferase, NscD-like (family) [11-418]
- IPR033964: Aromatic prenyltransferase (family) [12-421]
Interaction partners: - Beta-cyclopiazonate dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0030638 (polyketide metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0030639 (polyketide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: L-lactate dehydrogenase (EC 1.1.1.27) (Q5U077)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
InterPro domains: - IPR001557: L-lactate/malate dehydrogenase (family) [18-334]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [2-161]
- IPR001236: Lactate/malate dehydrogenase, N-terminal (domain) [23-161]
- IPR022383: Lactate/malate dehydrogenase, C-terminal (domain) [165-330]
- IPR011304: L-lactate dehydrogenase (family) [21-332]
- IPR015955: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (homologous_superfamily) [162-331]
- IPR018177: L-lactate dehydrogenase, active site (active_site) [191-197]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0006089 (lactate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006090 (pyruvate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0098857 (membrane microdomain), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0045121 (membrane raft), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane), GO:1903561 (extracellular vesicle)
Protein: CNR2 (O88690)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Sequence: MDFTTEGRLGTRCMLLSLLLLAAWEAGSGQLHYSVPEEPKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSVECSIHLEVIVDRPLQVFHVEVEVRDINDNPPVFSVKEQRMLIYESRLPDSLFPLEGASDADVGLNSMLTYKLSPSEYFGLDVKSNSDGNKQIRLLLKKSLDREDAPEHKLLLTATDGGKPELTGSVQLLVTVLDVNDNAPTFQHPEYEVRILENSDNGTTVIRLNASDKDEGTNSAISYSFNRLVPPKTLEQFSIDADTGEIITQGNLDFEQVDVYKIHVDATDKGHPPMVGHCTVLVKVLDENDNVPQITLTSLSLPVREDAALSTVIALISVSDLDSGSNGQVTCSLSPHVPFKLVSTFKNYYSLVLDSALDRETTADYQVVVTARDGGSPSLWTTASVSVEVADVNDNAPSFAQPDYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLLGPWTPGSGGVVSELVSPSVGAGQVVTKVRAVDADSGYNAWLSYELHPLAGGTRSLFRVGLYTGEISTTRALEEADAPRHRLLVLVKDHGEPALIATATVLVSLVENSQTPKASSRAQGATGQEVSLVNVNVYLIIAICAVSSLLVLTLMVYTALRCSVPPTEGVCGAGKPVLVCSSAVGSWSYSQQRRQKVCSGEGPPKTDLMAFSPSLPPCPVVGEHQDLNDDHCSRPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [17-769]
- IPR002126: Cadherin-like (domain) [21-678]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [796-929]
- IPR013164: Cadherin, N-terminal (domain) [30-111]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [30-670]
- IPR020894: Cadherin conserved site (conserved_site) [230-563]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Retinol dehydrogenase 10-A (EC 1.1.1.300) (A1L1W4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity).
Subcellular location: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MNIFVEFFLVMLKVCWAIVMAGFKWLIRPKEKSVAGQVCVITGAGGGLGRLFAKEFARRRATLVLWDINSHSNEETAEMVRQIYREQDNPMSKEGAVGGVEEVPPFQPQVYTYVLDVGKRESVYSTAEKVRREVGEVDLLINNAGVVSGHHLLECPDELIERTMVVNCHAHFWTTKAFLPKMLEMNHGHIVTVASSLGLFSTAGVEDYCASKFGAIGFHESLSHEIQASEKDGIKMTLVCPYLVDTGMFRGCRIRKEIEPFLPPLRPEFCVKQAMRAILTDQPMICTPRIVYMVNFMKSILPFEAIVCMYRFLGADKCMYPFLAQRKEAMNNNEAKNGI
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [32-313]
- IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [195-223]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [38-251]
Interaction partners: - Cytochrome P450 26A1
- Lecithin retinol acyltransferase b, tandem duplicate 2.
- Cytochrome P450 27C1
- Lecithin retinol acyltransferase a
- Aldehyde dehydrogenase 1 family member A3
- O-acyltransferase
- Patatin-like phospholipase domain-containing 4.
- O-acyltransferase.
- Lecithin retinol acyltransferase b, tandem duplicate 1.
- Retinoid isomerohydrolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004745 (NAD-retinol dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0048385 (regulation of retinoic acid receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Hyaluronidase-5 (Hyal-5) (EC 3.2.1.35) (Hyaluronoglucosaminidase-5) (Q812F3)
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments. Does not appear to be essential for fertilization.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16330764, ECO:0000269|PubMed:16925524}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:16330764, ECO:0000269|PubMed:16925524}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:16330764}. Secreted {ECO:0000269|PubMed:16330764}. Note=Located on the plasma and acrosomal membranes of acrosome-intact (AI) sperm and released during the acrosome reaction. {ECO:0000269|PubMed:16330764}.
Sequence: MRVLYFKHSFFRSLLKSNGLPQTLLVFLLIPCYLTVDFRAPPLIPDVPFLWAWNAPTESCFTRFNQPLDLGLFSLVGSPRKSATGQPVTIFYSDRLGLYPYIDDSQLIFNGGLPQLVSLKSHLEVAKTDILHYMPIDNVGLAVIDWEEWRPTWARNWKPKDIYRNKSIELVQQQNILLNFTEAVKWAKEEFEEAARHFMEETLRLGKSLRPNHLWGFYLFPDCYNNKFQVADYKGECPDIEKHRNDALFWIWEESTALYPSIYLKSSLKSSPQAALYVRNRVQEAIRVSKVKDPRNPLPIFVYFRIVFTDLTYQYLYEDDLVNTIGETIALGTSGMVMWGTLSLSQTMKSCLDLHDYLKTILNPYIINVTLAAKMCSQTLCQNQGVCSRKDWNSNDYLHLNPQNFQIHFVKHGKYEIRGNPTLENLLYFSQKFRCSCFAHLNCQERADIESVSTVSVCTLEDICINSLVISDKSELPKDWNRPYFVNSNQSDITSSATVSPCVPRKDVSGYLVVLSLYSQHLKYSL
InterPro domains: - IPR018155: Hyaluronidase (family) [1-525]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [48-368]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [38-456]
- IPR001439: Hyaluronidase PH20/Hyaluronidase-5 (family) [1-519]
Interaction partners: - Beta-glucuronidase
- Alpha-L-iduronidase
- Arylsulfatase B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015929 (hexosaminidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0009566 (fertilization), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0009897 (external side of plasma membrane), GO:0030141 (secretory granule), GO:0098857 (membrane microdomain), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Type II secretion system protein H (General secretion pathway protein H) (E0SLG0)
Organism: Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
Function: Not known
Subcellular location: Cell inner membrane {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004377}.
Sequence: MRQRGFTLLEIMLVVLLAGVAATLVMMAIPAPKQQDSGWQIARFKAQLQYAVEDSQMNDHILGIYIQPRRWQYALLQRQVVENSPDDQQRLRYVWVPWQPYRMSSPSELPDGFQIELSTQVGAAGDGAGFSPGNGDPHILILPGGEVTPFRLTLRNGNDSAWLQVDTNGRVQTSPEAEQ
InterPro domains: - IPR045584: Pilin-like (homologous_superfamily) [6-176]
- IPR049875: Type II secretion system minor pseudopilin GspH (family) [3-173]
- IPR022346: General secretion pathway, GspH (domain) [74-168]
- IPR012902: Prokaryotic N-terminal methylation site (ptm) [1-26]
- IPR002416: Type II secretion system protein GspH-like (family) [1-152]
Interaction partners: - Type II secretion system protein J
- Type II secretion system protein L
- Type II secretion system core protein G
- Type II secretion system protein M
- Type II secretion system protein K
- Type II secretion system protein C
- Type II secretion system protein I
- Secretin OutD
- Type II secretion system protein F
- Type II secretion system protein E
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0043107 (type IV pilus-dependent motility), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0030031 (cell projection assembly), GO:0043711 (pilus organization), GO:0009297 (pilus assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0043226 (organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium)
Protein: Sirohydrochlorin cobaltochelatase (EC 4.99.1.3) (Anaerobic cobalt chelatase) (Q05592)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
Sequence: MKKALLVVSFGTSYHDTCEKNIVACERDLAASCPDRDLFRAFTSGMIIRKLRQRDGIDIDTPLQALQKLAAQGYQDVAIQSLHIINGDEYEKIVREVQLLRPLFTRLTLGVPLLSSHNDYVQLMQALRQQMPSLRQTEKVVFMGHGASHHAFAAYACLDHMMTAQRFPARVGAVESYPEVDILIDSLRDEGVTGVHLMPLMLVAGDHAINDMASDDGDSWKMRFNAAGIPATPWLSGLGENPAIRAMFVAHLHQALNMAVEEAA
InterPro domains: - IPR010388: Anaerobic cobalt chelatase (family) [1-264]
Interaction partners: - Cobalt-precorrin-4 C
- Cobalt-precorrin-5A hydrolase
- Cobalt-precorrin-2 C
- Cobalt-precorrin-5B C
- Cobalt-precorrin-6A reductase
- Probable cobalt-factor III C
- Cobyrinate a,c-diamide synthase
- Cobalt-precorrin-8 methylmutase
- Cobalt-precorrin-7 C
- Siroheme synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:1901661 (quinone metabolic process), GO:0042181 (ketone biosynthetic process), GO:0006743 (ubiquinone metabolic process), GO:1901663 (quinone biosynthetic process), GO:0006744 (ubiquinone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Spore protein YabQ (P37559)
Organism: Bacillus subtilis (strain 168)
Function: Required for sporulation. Plays an important role in cortex and coat formation.
Subcellular location: Forespore outer membrane {ECO:0000269|PubMed:11283287, ECO:0000269|PubMed:15231775}; Multi-pass membrane protein {ECO:0000269|PubMed:11283287, ECO:0000269|PubMed:15231775}.
Sequence: MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIHDILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLVVSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFPIRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR
InterPro domains: - IPR019074: Spore cortex biosynthesis protein, YabQ (family) [3-90]
Interaction partners: - Spore protein YabP
- Cell division protein DivIC
- Stage III sporulation protein AC
- Sigma-K factor-processing regulatory protein BofA
- Anti-sigma-F factor Fin
- Stage IV sporulation protein FA
- Uncharacterized protein YqfD
- Uncharacterized protein YabS
- Stage II sporulation protein E
- Sporulation sigma-E factor-processing peptidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0051094 (positive regulation of developmental process), GO:0050793 (regulation of developmental process), GO:0043937 (regulation of sporulation), GO:0043938 (positive regulation of sporulation), GO:0042173 (regulation of sporulation resulting in formation of a cellular spore), GO:0045881 (positive regulation of sporulation resulting in formation of a cellular spore)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)
Protein: Cx9C motif-containing protein 4 (Mature T-cell proliferation 1 neighbor protein) (Mature T-cell proliferation-1 type A) (MTCP-1 type A) (Protein p8 MTCP-1) (p8MTCP1) (P56277)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000269|PubMed:7784073}.
Sequence: MPQKDPCQKQACEIQKCLQANSYMESKCQAVIQELRKCCAQYPKGRSVVCSGFEKEEEENLTRKSASK
InterPro domains: - IPR027179: Cx9C motif-containing protein 4 (family) [2-59]
- IPR009069: Cysteine alpha-hairpin motif superfamily (homologous_superfamily) [1-64]
Interaction partners: - COX assembly mitochondrial protein 2 homolog
- Cytochrome c oxidase assembly factor 4 homolog, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0061077 (chaperone-mediated protein folding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0031970 (organelle envelope lumen), GO:0070013 (intracellular organelle lumen), GO:0005758 (mitochondrial intermembrane space)
Protein: Eukaryotic translation initiation factor 1 (eIF1) (Protein translation factor SUI1 homolog) (P48024)
Organism: Mus musculus (Mouse)
Function: Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P41567}.
Sequence: MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIEHPEYGEVIQLQGDQRKNICQFLIEIGLAKDDQLKVHGF
InterPro domains: - IPR005874: Eukaryotic translation initiation factor SUI1 (family) [1-113]
- IPR001950: SUI1 domain (domain) [28-101]
- IPR036877: SUI1 domain superfamily (homologous_superfamily) [3-113]
Interaction partners: - Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
- Eukaryotic translation initiation factor 3 subunit I
- Eukaryotic translation initiation factor 3 subunit G
- Ubiquitin-like protein FUBI
- Eukaryotic translation initiation factor 2 subunit 2
- Eukaryotic translation initiation factor 3 subunit D
- Eukaryotic translation initiation factor 1A
- Eukaryotic translation initiation factor 3 subunit A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0034248 (regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0006446 (regulation of translational initiation), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0006417 (regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:2000112 (regulation of cellular macromolecule biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)