Protein: Protein wings apart-like (Q9W517)
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in female meiotic chromosome segregation in females; proximal heterochromatin is involved in chromosome pairing during female meiosis. Is a dominant suppressor of both white and Stubble position-effect variegation (PEV), while it is a weak enhancer of brown variegation
Sequence: MSRWGKNIVVPLDSLCKEKENTNRPTVARSVGTVGKWGKMGFTSTRTYTLPAIHPMAAAAAAAAAAASPSQSPASTQDHDPNDLSVSVPEPPKPKKFFKSRNTAPPEVIAQIIQQLPHCGAGASPMRDHFSSAGAGAGGLTPTSGAQEAGGVKLKPGKGASSAERKRKSPKKKAATTSASTPSTPGAFYGASDRDGDGLSDPASEQPEQPSSASGKQKQKKPKEEKKLKPEAPPSRVLGRARKAVNYREVDEDERYPTPTKDLIIPKAGRQPAEVAATATLAAASSEAFISSTFGSPGSEPSLPPPTSAPSASASTSSQLPSASGSASNPPSASRTPEHPPIVLRISKGTSRLVSTDSEEPPSSSPAHQNQLNQLSVTEEEPAERSGDETVPASTPKITVKPLRPPTAADSVDGSSAAVGGASAGDSFEERKSQSLEPNEDEEEEEEEEDEEEEPPEINYCTVKISPDKPPKERLKLIIKTDVIRNAIAKAAAAAESRSEKKSRSKKHKHKQLLAAGSGAAPASGATPAEINSEFKTPSPHLALSEANSQQAQHTPSHLHQLHQLHPQRGSAVISPTTRSDHDFDSQSSVLGSISSKGNSTPQLLAQAVQEDSCVIRSRGSSVITSDLETSQHSSLVAPPSDIESRLESMMMTIDGAGTGAASAVPETPLQEDILAVLRGEVPRLNGNTDPEPTEEEDQQQQPKRATRGRGRKANNNVDVTPPATETRTRGRAKGADATTAAISPPTGKRNTRGTRGSRKAEQEVDMEVDETAMTTVPANEEQLEQATLPPRRGRNAAARANNNNLASVNNNINKIAANLSAKAEASRLAEGGVAGGAARSYGRKRKNQQVTQVLQQEPVPEEQETPDAEEEQPTPAKIPHTDHREHSPDHDPDPDPDELSNNSNNSSLQHDGSSSSPPPRDFKFKDKFKRTLTLDTQGAANAGAGGAAAAAPPESSGEQRGAVKLVISKKKGSIFKSRALVPSDQAEQATVAKRHLYKHSWDAALEANGGGTNSDASNASASGVGVAGAKDHLHHLAAGKSDGDFGDSPSSNNNGSSSACSSASTLRGDSPALGKISRLAGKQGVPATSTSSDAFDLDLEPIAGELDLERSAAGASAGGTGATTGGGGATGGGGPVRVDRKTKDYYPVVRNVKTAHQIQEIGEYQEMDDDVEYILDALQPHNPPATRCLSALQLAAKCMMPAFRMHVRAHGVVTKFFKALSDANKDLSLGLCTSAIMYILSQEGLNMDLDRDSLELMINLLEADGVGGSTETGHPDRAGYDRNKQKVRELCEEIKAQGKGTHLNVDSLTVGTLAMETLLSLTSKRAGEWFKEDLRKLGGLEHIIKTISDFCRPVIACDTEIDWQPTLLDNMQTVARCLRVLENVTQHNETNQRYMLTSGQGKAVETLCQLYRLCSRQIMLHPSDGGGSNKEHPGVAMRELLVPVLKVLINLTHTFNEAQPSLGAELLGQRGDVVETSFRLLLLSANYIPDQCVFELSILVLTLLINLCMHTVPNRAALMQAAAPAEYVADNPPAQGSVSALQALLEYFYKCEELARLVEKNTDAFLESNEKGKKKQEEVEETVNNLVQRAGHHMEHTLKGSYAAILVGNLIADNELYESVVRRQLRGNSFKEIIGVLEKYHTFMNLTSSLEAAFVAHMKSTKRIIDNFKKRDYIYEHSDEHDNPLPLNLETTAQVLAVGADASHAATSSTTVGSGSAPSSTSATGTTRAPRVYKTYSSHR
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [1169-1557]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1138-1671]
- IPR012502: WAPL domain (domain) [1140-1648]
- IPR039874: Wings apart-like protein (family) [845-1673]
- IPR022771: Wings apart-like protein, C-terminal (domain) [1152-1513]
Interaction partners: - Precocious dissociation of sisters 5, isoform A
- Structural maintenance of chromosomes protein
- FI11703p
- MAU2 chromatid cohesion factor homolog
- Nipped-B protein
- LD34181p
- separase
- Structural maintenance of chromosomes protein
- Chromosomal protein D1
- CTCF
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0003682 (chromatin binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0042802 (identical protein binding), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0046975 (histone H3K36 methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0051129 (negative regulation of cellular component organization), GO:0044092 (negative regulation of molecular function), GO:0016043 (cellular component organization), GO:0007062 (sister chromatid cohesion), GO:0045786 (negative regulation of cell cycle), GO:0051098 (regulation of binding), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0010639 (negative regulation of organelle organization), GO:0051100 (negative regulation of binding), GO:0051101 (regulation of DNA binding), GO:0007063 (regulation of sister chromatid cohesion), GO:0006325 (chromatin organization), GO:0033043 (regulation of organelle organization), GO:0006996 (organelle organization), GO:0043392 (negative regulation of DNA binding), GO:2001251 (negative regulation of chromosome organization), GO:0033044 (regulation of chromosome organization), GO:0051276 (chromosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome), GO:0005700 (polytene chromosome)