Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (A0A0B4LHX7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNGGGRTPALTRSCSSPAVYDIETHPASPVFPHLLLGNGRDADDPSSVGANCVLNVTCQSPNESHLQGLKYMQIPASDTPHQNIKQYFQEAYDFIEDARKTGSRVLLHCHAGISRSATIAIAYVMRYKSLSLLEAYKLVKVARPIISPNLNFMGQLLELEQNLRKSGVLAPATPHLNSPSNPSSSSVGLSTQSSQLVEQPEEEEKREQRERGKSKSDSEAMDEDGFDYDDVDSGSGSLAGSNCSSRLTSPPITPDDEAPSTSAAASSVSELDSPSSTSSSSGICSLLQSTSSSVSPRAISKPNLLSPTRQLALFKRNSPAKLRLDLESSYAPASPIPNTMPWLSVPSTPVCEEAPDSRINHVASNLTRD
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [12-169]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [85-144]
- IPR020422: Dual specificity protein phosphatase domain (domain) [25-165]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [107-117]
- IPR000340: Dual specificity phosphatase, catalytic domain (domain) [49-161]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008138 (protein tyrosine/serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0007389 (pattern specification process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:2000243 (positive regulation of reproductive process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0002683 (negative regulation of immune system process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0008340 (determination of adult lifespan), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:1903684 (regulation of border follicle cell migration), GO:0060759 (regulation of response to cytokine stimulus), GO:0002165 (instar larval or pupal development), GO:0009968 (negative regulation of signal transduction), GO:0007552 (metamorphosis), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:1903688 (positive regulation of border follicle cell migration), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0048608 (reproductive structure development), GO:0061060 (negative regulation of peptidoglycan recognition protein signaling pathway), GO:0042335 (cuticle development), GO:0060761 (negative regulation of response to cytokine stimulus), GO:0045184 (establishment of protein localization), GO:0031348 (negative regulation of defense response), GO:0006793 (phosphorus metabolic process), GO:0035295 (tube development), GO:0051726 (regulation of cell cycle), GO:0010632 (regulation of epithelial cell migration), GO:0009887 (animal organ morphogenesis), GO:0035112 (genitalia morphogenesis), GO:0050778 (positive regulation of immune response), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0007548 (sex differentiation), GO:0009886 (post-embryonic animal morphogenesis), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0010564 (regulation of cell cycle process), GO:0035239 (tube morphogenesis), GO:0007276 (gamete generation), GO:0030707 (follicle cell of egg chamber development), GO:0007281 (germ cell development), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0009611 (response to wounding), GO:0006979 (response to oxidative stress), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009799 (specification of symmetry), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0090598 (male anatomical structure morphogenesis), GO:0002831 (regulation of response to biotic stimulus), GO:0048598 (embryonic morphogenesis), GO:0050776 (regulation of immune response), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0046843 (dorsal appendage formation), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0007306 (egg chorion assembly), GO:0046661 (male sex differentiation), GO:0002832 (negative regulation of response to biotic stimulus), GO:0032102 (negative regulation of response to external stimulus), GO:0034599 (cellular response to oxidative stress), GO:0035592 (establishment of protein localization to extracellular region), GO:0031347 (regulation of defense response), GO:0007346 (regulation of mitotic cell cycle), GO:0071705 (nitrogen compound transport), GO:0046529 (imaginal disc fusion, thorax closure), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0055123 (digestive system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0048880 (sensory system development), GO:0000165 (MAPK cascade), GO:0048707 (instar larval or pupal morphogenesis), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0071702 (organic substance transport), GO:0002009 (morphogenesis of an epithelium), GO:0030334 (regulation of cell migration), GO:0016331 (morphogenesis of embryonic epithelium), GO:1900424 (regulation of defense response to bacterium), GO:0010468 (regulation of gene expression), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0022607 (cellular component assembly), GO:0040003 (chitin-based cuticle development), GO:0043412 (macromolecule modification), GO:0048568 (embryonic organ development), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0008544 (epidermis development), GO:0015031 (protein transport), GO:1900425 (negative regulation of defense response to bacterium), GO:0030335 (positive regulation of cell migration), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0001960 (negative regulation of cytokine-mediated signaling pathway), GO:0061458 (reproductive system development), GO:0045088 (regulation of innate immune response), GO:0009306 (protein secretion), GO:0048562 (embryonic organ morphogenesis), GO:0046528 (imaginal disc fusion), GO:0062197 (cellular response to chemical stress), GO:0007423 (sensory organ development), GO:0048477 (oogenesis), GO:0048806 (genitalia development), GO:0046903 (secretion), GO:0010628 (positive regulation of gene expression), GO:0062207 (regulation of pattern recognition receptor signaling pathway), GO:0006796 (phosphate-containing compound metabolic process), GO:0030539 (male genitalia development), GO:1902532 (negative regulation of intracellular signal transduction), GO:0045229 (external encapsulating structure organization), GO:0048546 (digestive tract morphogenesis), GO:0030855 (epithelial cell differentiation), GO:0035126 (post-embryonic genitalia morphogenesis), GO:0036211 (protein modification process), GO:0009855 (determination of bilateral symmetry), GO:0048808 (male genitalia morphogenesis), GO:0042060 (wound healing), GO:0060972 (left/right pattern formation), GO:1901987 (regulation of cell cycle phase transition), GO:0048569 (post-embryonic animal organ development), GO:0010634 (positive regulation of epithelial cell migration), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0048565 (digestive tract development), GO:1902531 (regulation of intracellular signal transduction), GO:0009792 (embryo development ending in birth or egg hatching)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)