Protein: 3-aminoacrylate deaminase RutC (P0AFQ5)
Organism: Escherichia coli (strain K12)
Function: Involved in pyrimidine catabolism. Catalyzes the deamination of 3-aminoacrylate to malonic semialdehyde, a reaction that can also occur spontaneously. RutC may facilitate the reaction and modulate the metabolic fitness, rather than catalyzing essential functions. In vitro, can also deaminate 2-aminoacrylate
Sequence: MPKSVIIPAGSSAPLAPFVPGTLADGVVYVSGTLAFDQHNNVLFADDPKAQTRHVLETIRKVIETAGGTMADVTFNSIFITDWKNYAAINEIYAEFFPGDKPARFCIQCGLVKPDALVEIATIAHIAK
InterPro domains: - IPR019898: 3-aminoacrylate deaminase RutC (family) [1-128]
- IPR035959: RutC-like superfamily (homologous_superfamily) [1-128]
- IPR006175: YjgF/YER057c/UK114 family (family) [13-126]
- IPR019897: RidA, conserved site (conserved_site) [102-120]
Interaction partners: - Putative carbamate hydrolase RutD
- Ureidoacrylate amidohydrolase RutB
- Probable malonic semialdehyde reductase RutE
- Pyrimidine monooxygenase RutA
- FMN reductase (NADH) RutF
- Putative pyrimidine permease RutG
- NADP-dependent 3-hydroxy acid dehydrogenase YdfG
- RutC family protein YoaB
- RutC family protein YoaB
- RutC family protein YoaB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0051082 (unfolded protein binding), GO:0019239 (deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0044248 (cellular catabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0009112 (nucleobase metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0031667 (response to nutrient levels), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0046113 (nucleobase catabolic process), GO:0019740 (nitrogen utilization), GO:0006206 (pyrimidine nucleobase metabolic process), GO:0072529 (pyrimidine-containing compound catabolic process), GO:0006208 (pyrimidine nucleobase catabolic process), GO:0019860 (uracil metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0016020 (membrane)