Protein: Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) (P26045)
Organism: Homo sapiens (Human)
Function: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Sequence: MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLAPQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDDFHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRINPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRRAVRSFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQMLDPS
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [495-597]
- IPR018979: FERM, N-terminal (domain) [33-96]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [109-216]
- IPR019749: Band 4.1 domain (domain) [25-222]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [217-311]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [112-217]
- IPR012151: Protein-tyrosine phosphatase, non-receptor type-3, -4 (family) [1-913]
- IPR001478: PDZ domain (domain) [510-598]
- IPR041783: PTPN3/4, FERM domain C-lobe (domain) [216-309]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [819-892]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [840-850]
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [629-911]
- IPR019747: FERM conserved site (conserved_site) [84-221]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [27-112]
- IPR000299: FERM domain (domain) [29-312]
- IPR018980: FERM, C-terminal PH-like domain (domain) [226-316]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [800-900]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [645-903]
- IPR019748: FERM central domain (domain) [113-222]
Interaction partners: - Mitogen-activated protein kinase 12
- 6-pyruvoyl tetrahydrobiopterin synthase
- Transitional endoplasmic reticulum ATPase
- Epidermal growth factor receptor substrate 15
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity), GO:0004726 (non-membrane spanning protein tyrosine phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005886 (plasma membrane), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0009898 (cytoplasmic side of plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)