Protein: Phosphoglycerate mutase 1 (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B) (P25113)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate. Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate.
Sequence: MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKVKK
InterPro domains: - IPR005952: Phosphoglycerate mutase 1 (family) [3-251]
- IPR001345: Phosphoglycerate/bisphosphoglycerate mutase, active site (active_site) [8-17]
- IPR029033: Histidine phosphatase superfamily (homologous_superfamily) [1-254]
- IPR013078: Histidine phosphatase superfamily, clade-1 (family) [5-228]
Interaction partners: - Phosphoglycerate kinase 1
- Alpha-enolase
- Gamma-enolase
- Phosphoglycerate kinase
- Beta-enolase
- Phosphoglycerate mutase 2
- Glucose-6-phosphate isomerase
- Fructose-bisphosphate aldolase A
- Enolase 4
- D-3-phosphoglycerate dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0016868 (intramolecular transferase activity, phosphotransferases), GO:0004619 (phosphoglycerate mutase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0044281 (small molecule metabolic process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:0005996 (monosaccharide metabolic process), GO:0010035 (response to inorganic substance), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0007283 (spermatogenesis), GO:0010038 (response to metal ion), GO:0019318 (hexose metabolic process), GO:0048232 (male gamete generation), GO:0046364 (monosaccharide biosynthetic process), GO:0016051 (carbohydrate biosynthetic process), GO:0006006 (glucose metabolic process), GO:0046689 (response to mercury ion), GO:0019319 (hexose biosynthetic process), GO:0006094 (gluconeogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)