Protein: Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2-containing protein 5) (O54928)
Organism: Mus musculus (Mouse)
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Sequence: MDKVGKMWNNLKYRCQNLFSHEGGSRNENVEMNPNRCPSVKEKSISLGEAAPQQESSPLRENVALQLGLSPSKTFSRRNQNCAAEIPQVVEISIEKDSDSGATPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDTEKKFGRTRSGLQRRERRYGVSSMQDMDSVSSRAVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDGSAIPQTNCDSEEDSTTLCLQSRRQKQRQVSGDSHAHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
InterPro domains: - IPR022252: SOCS4/SOCS5 domain (domain) [147-195]
- IPR036036: SOCS box-like domain superfamily (homologous_superfamily) [482-523]
- IPR037343: SOCS5, SOCS box domain (domain) [479-534]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [362-532]
- IPR000980: SH2 domain (domain) [379-476]
- IPR001496: SOCS box domain (domain) [471-520]
Interaction partners: - Tyrosine-protein kinase JAK2
- Interleukin-4 receptor subunit alpha
- Elongin-C
- Cullin-5
- Non-receptor tyrosine-protein kinase TYK2
- Signal transducer and activator of transcription 3
- Elongin-B
- Suppressor of cytokine signaling 3
- Signal transducer and activator of transcription
- Signal transducer and activator of transcription 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0019900 (kinase binding), GO:0030971 (receptor tyrosine kinase binding), GO:0019901 (protein kinase binding), GO:1990782 (protein tyrosine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045598 (regulation of fat cell differentiation), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0032496 (response to lipopolysaccharide), GO:0002521 (leukocyte differentiation), GO:0032355 (response to estradiol), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0051248 (negative regulation of protein metabolic process), GO:0048732 (gland development), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0030099 (myeloid cell differentiation), GO:0061008 (hepaticobiliary system development), GO:0050727 (regulation of inflammatory response), GO:0033993 (response to lipid), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0045765 (regulation of angiogenesis), GO:0051338 (regulation of transferase activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:1903131 (mononuclear cell differentiation), GO:0043410 (positive regulation of MAPK cascade), GO:0002573 (myeloid leukocyte differentiation), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0043409 (negative regulation of MAPK cascade), GO:0032873 (negative regulation of stress-activated MAPK cascade), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0043407 (negative regulation of MAP kinase activity), GO:0045859 (regulation of protein kinase activity), GO:0071347 (cellular response to interleukin-1), GO:0071356 (cellular response to tumor necrosis factor), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0046329 (negative regulation of JNK cascade), GO:0043508 (negative regulation of JUN kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0043506 (regulation of JUN kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)