Protein: Dipeptidyl peptidase 4 (B0R1C4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein
Sequence: MGCNKVCVALVGAVVVITLIAIPTAIYVNRDDSALKRTYSFDDFYNDTIRYKTYNLRWISDNEYLHKTNEGHIYLHNAETKESSVYLSNSTFAQVDATDYILSADRKFAAFESNYSKQWRHSFTASYSIYNVESGEFLSKVQIPHVTQLLTWAPVGNKLAYVWNFNIYLKASATAEAVQVTHNGKGNEILNGVPDWVYEEEVFASNEAIWWSPQGKYLAYLQVNDTGVHSIEYSLYGNDQYPVTVFVPYPKAGSVIPRARLFVIDVENPSRQSEVVVPKSVGSGDHYLSTVTWVTDDRLAVQWMPRRQDSVLLQIYDYDGTKWKESTKFEQKSKTGWVGRYFPSAPYFAANNMSFYKVMSNDNGYKHLHYVNAGKATPITSGKWEVIYISKVTKDSIYYVSNEHMARPGQRNLYKISISSSGHSAPKCLTCALYEDRCQYNSAYFSLNASYFRMDCYGPGLPLFTMMDNRGPAKETQVLEDNKKLENILTTELLMPTKKRGTLKIAGFDLWYQMMFPPNFDSSKKYPLLIDVYGGPASQNIDYVFRLEWATYLCSTERIIVASFDGRGSGFQGDEIMHAIYERLGTYEVEDQITAVRKFIEMGFIDKDRIAMWGWSYGGYVTSMALGSGSGLFKCGIAVAPVAKWEYYDAVYTERYMHRPQDNFESYKNSTVTDRAKNFKSVQYLLVHGTADDNVHFQQAAQISKALVENQVDFEAMWYTDKDHSLSGKARYHLYTHLNHFLKNCFAEKK
InterPro domains: - IPR040522: Dipeptidyl peptidase 4, low complexity region (domain) [35-54]
- IPR002469: Dipeptidylpeptidase IV, N-terminal domain (domain) [103-462]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [487-749]
- IPR050278: Serine protease S9B/DPPIV (family) [10-746]
- IPR002471: Peptidase S9, serine active site (active_site) [591-621]
- IPR001375: Peptidase S9, prolyl oligopeptidase, catalytic domain (domain) [547-747]
Interaction partners: - Glucagon b
- Mapk-regulated corepressor-interacting protein 1
- Adenosine deaminase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008238 (exopeptidase activity), GO:0008239 (dipeptidyl-peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0003206 (cardiac chamber morphogenesis), GO:0003170 (heart valve development), GO:0003179 (heart valve morphogenesis), GO:0003205 (cardiac chamber development), GO:0007626 (locomotory behavior), GO:0003208 (cardiac ventricle morphogenesis), GO:0003209 (cardiac atrium morphogenesis), GO:0003171 (atrioventricular valve development), GO:0003007 (heart morphogenesis), GO:0042692 (muscle cell differentiation), GO:1903034 (regulation of response to wounding), GO:0055001 (muscle cell development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0010611 (regulation of cardiac muscle hypertrophy), GO:0003230 (cardiac atrium development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0003230 (cardiac atrium development), GO:0007517 (muscle organ development), GO:1902531 (regulation of intracellular signal transduction), GO:0003181 (atrioventricular valve morphogenesis), GO:0007507 (heart development), GO:0022607 (cellular component assembly), GO:0007519 (skeletal muscle tissue development), GO:0043408 (regulation of MAPK cascade), GO:0051146 (striated muscle cell differentiation), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0060538 (skeletal muscle organ development), GO:0055008 (cardiac muscle tissue morphogenesis), GO:0055010 (ventricular cardiac muscle tissue morphogenesis), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0005764 (lysosome), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)