Protein: Cytoplasmic dynein 2 light intermediate chain 1 (Q7SXY4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q8TCX1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8TCX1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K0T2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8TCX1}. Note=Localizes to the apical cytoplasm. {ECO:0000250|UniProtKB:Q8K0T2}.
Sequence: MPKVSSDTLWDIAAAEVRSRESRTDEEEAEEEDAHFPSQRTVFFMGSKAGGKTTILLRFLERDETAKPTLALEYTFGRRARGHNTPKDIAHLWELGGGISLSDLVQIPITADNVSFLSVVLVLDLSKPNALWETMESLLGSARNQVEKVCAALQKTGESRSGKQRVPRVLHKDYPDRELISPFPVPLLIVGSKFDIFQDFDSEKRKVICKTLRFLAHFYGASLIFTSSKSETTMSKSRSFINQLAFGTERPKSISTDPSKPLAIPAGSDSLSQIGPPVATEVDIGTLHAKNPFDLWKKVFEKVFPHESTRERKELKDPVKDPQFSEPLIDSIRAQKDQELDQYKREQAKSWKSLALDP
InterPro domains: - IPR022780: Dynein family light intermediate chain (family) [33-149]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [22-245]
- IPR040045: Cytoplasmic dynein 2 light intermediate chain 1 (family) [1-354]
Interaction partners: - Cytoplasmic dynein 2 intermediate chain 1 isoform X2
- WD repeat domain 34
- Tctex1 domain-containing 2.
- Dynein cytoplasmic 2 heavy chain 1.
- Dynein light chain roadblock-type 2.
- Dynein light chain roadblock
- Dynein light chain Tctex-type 1
- Dynein light chain
- WD repeat-containing protein 35
- WD repeat domain 19.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0009799 (specification of symmetry), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0003002 (regionalization), GO:0009855 (determination of bilateral symmetry), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0060972 (left/right pattern formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0007368 (determination of left/right symmetry), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)