Protein: Alpha-N-acetylglucosaminidase (Q9VLL5)
Organism: Drosophila melanogaster (Fruit fly)
Sequence: MQLNWKLALALLAVLCLQLAQGSELNWDAASGPEMGLQMAAHLAPSTPKDVQETAAMAVISRVIGERSSQLFKVQVNKNMDLRSFQISMLDDGRILLMGWDGVSVCKALHHYLKYVLNKDVDWFKMRIELPTNLQLPNVTIESKSASPIIYHQNVCTWSYSFAWWGIEQWRRHLDWMALMGISLTIAPVQEAIWVKVYTDMGLRMEEIDEHLAGPAFQAWQRMGNIRGWAGPLTPAWRRYQLLLQQEIITAQRNLGMSVALPAFAGHVPRALKRLNPESTFMEVQRWNQFPDRYCCGLFVEPTENLFKEIASRFLHNIITKYGSNHIFFCDPFNELEPPVAKPEYMRSTAAAIYESMRGIDPQAIWLLQGWMFVKNPFWTTDMAEAFLTAAPRGRILVLDLQSEQFPQYELTRSYFGQPFIWCMLHNFGGTLGMFGSAKLINSGIEEARRLPNSSLVGTGITPEGIGQNYVMYSFTLERGWSNTSLDLDSWFTNFSHSRYGVKDERLEQAWLLLKNSVYSFRGLQKMRGQYVVTRRPSFNQEPFTWYNASAVLDAWHLLLTFRAIIPLEDNRYEIYEHDLVDITRQFLQISADQLYINLRSAYRKRQVSRFEFLSVKLLKLFDDMELILASSRNFLLGNWLQQAKQAAPNTGQQRNFEFNARNQITAWGPDGQILDYACKQWSGLVSDYYRPRWRLFLEDVTVALHAGRPFNGTAFKLKVSHEIELPFSNKDDVYPVTPVGNTWLISQDIFETWKGYSKDTLFLHNNRLSVPQKAGPK
InterPro domains: - IPR007781: Alpha-N-acetylglucosaminidase (family) [11-755]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [160-402]
- IPR024240: Alpha-N-acetylglucosaminidase, N-terminal (domain) [55-137]
- IPR024733: Alpha-N-acetylglucosaminidase, tim-barrel domain (domain) [151-482]
- IPR029018: Beta-hexosaminidase-like, domain 2 (homologous_superfamily) [37-144]
- IPR024732: Alpha-N-acetylglucosaminidase, C-terminal (domain) [491-752]
Interaction partners: - Heparan-alpha-glucosaminide N-acetyltransferase, isoform A
- Regulatory protein zeste
- N-sulfoglucosamine sulfohydrolase
- Iduronate 2-sulfatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015929 (hexosaminidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1901564 (organonitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0009100 (glycoprotein metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0006029 (proteoglycan metabolic process), GO:0006517 (protein deglycosylation), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0006516 (glycoprotein catabolic process), GO:0030167 (proteoglycan catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0005764 (lysosome), GO:0043202 (lysosomal lumen)