Protein: Putative inactive cadmium/zinc-transporting ATPase HMA3 (Putative inactive cadmium/zinc-transporting ATPase 4) (Putative inactive protein HEAVY METAL ATPASE 3) (P0CW77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MAEGEESKKMNLQTSYFDVVGICCSSEVSIVGNVLRQVDGVKEFSVIVPSRTVIVVHDTFLISPLQIVKALNQARLEASVRPYGETSLKSQWPSPFAIVSGVLLVLSFFKYFYSPLEWLAIVAVVAGVFPILAKAVASVTRFRLDINALTLIAVIATLCMQDFTEAATIVFLFSVADWLESSAAHKASIVMSSLMSLAPRKAVIADTGLEVDVDEVGINTVVSVKAGESIPIDGVVVDGSCDVDEKTLTGESFPVSKQRESTVMAATINLNGYIKVKTTALARDCVVAKMTKLVEEAQKSQTKTQRFIDKCSRYYTPAVVVSAACFAVIPVLLKVQDLSHWFHLALVVLVSGCPCGLILSTPVATFCALTKAATSGFLIKTGDCLETLAKIKIVAFDKTGTITKAEFMVSDFRSLSPSINLHKLLYWVSSIECKSSHPMAAALIDYARSVSVEPKPDIVENFQNFPGEGVYGRIDGQDIYIGNKRIAQRAGCLTDNVPDIEATMKRGKTIGYIYMGAKLTGSFNLLDGCRYGVAQALKELKS
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [208-294]
- IPR001757: P-type ATPase (family) [169-412]
- IPR051014: Cation Transport ATPase Type IB (family) [9-542]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [397-529]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [397-403]
- IPR036163: Heavy metal-associated domain superfamily (homologous_superfamily) [11-84]
- IPR023214: HAD superfamily (homologous_superfamily) [386-541]
- IPR027256: P-type ATPase, subfamily IB (family) [146-541]
- IPR006121: Heavy metal-associated domain, HMA (domain) [13-79]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [148-389]
Interaction partners: - Copper chaperone for superoxide dismutase, chloroplastic/cytosolic
- Metal tolerance protein A2
- Metal tolerance protein 1
- Solute carrier family 40 member 2
- Metal transporter Nramp5
- Metal transporter Nramp3
- Metal transporter Nramp4
- Fe
- Fe
- Protein ZINC INDUCED FACILITATOR 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005375 (copper ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0061687 (detoxification of inorganic compound), GO:0010035 (response to inorganic substance), GO:0071585 (detoxification of cadmium ion), GO:0097501 (stress response to metal ion), GO:0009636 (response to toxic substance), GO:1990170 (stress response to cadmium ion), GO:0010038 (response to metal ion), GO:0046686 (response to cadmium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)