Protein: Ubiquitin-protein ligase E3A (EC 2.3.2.26) (F1M7B8)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|PIRNR:PIRNR037201}. Nucleus {ECO:0000256|PIRNR:PIRNR037201}.
Sequence: MATACKRSSGESQSEDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGASNNSEIKMNKKEEFKEVDYLTEEKVYEIYEFCREREDYSPLIRVIGRIFSSAEALVQSFRKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAMEEDSEASSSRMGDSSQGDNNVQKLGPDDVTVDIDAIRRVYSSLLSDEKIETAFLNALVYLSPNVECDLTYHNVYTRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYSADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETEIGVKTLDCRKPLISFEEFINEPLNDVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATRLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFCDLGDSHPILYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVSLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML
InterPro domains: - IPR000569: HECT domain (domain) [516-868]
- IPR017134: Ubiquitin-protein ligase E3A (family) [1-868]
- IPR032353: Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (domain) [27-81]
- IPR035983: HECT, E3 ligase catalytic domain (homologous_superfamily) [514-861]
- IPR042556: Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily (homologous_superfamily) [22-85]
- IPR044611: Ubiquitin-protein ligase E3A/B/C-like (family) [27-867]
Interaction partners: - Cellular tumor antigen p53
- Tuberin
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Catenin beta-1
- Hamartin
- Transcriptional repressor NF-X1
- Disks large homolog 1
- Proteasome
- Protein scribble homolog
- Disks large homolog 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0007610 (behavior), GO:0060998 (regulation of dendritic spine development), GO:0010035 (response to inorganic substance), GO:0051129 (negative regulation of cellular component organization), GO:1901698 (response to nitrogen compound), GO:0006979 (response to oxidative stress), GO:0007611 (learning or memory), GO:0070848 (response to growth factor), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0071495 (cellular response to endogenous stimulus), GO:0050803 (regulation of synapse structure or activity), GO:1901700 (response to oxygen-containing compound), GO:0050877 (nervous system process), GO:0035640 (exploration behavior), GO:0051128 (regulation of cellular component organization), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0007626 (locomotory behavior), GO:0050890 (cognition), GO:0061001 (regulation of dendritic spine morphogenesis), GO:0035641 (locomotory exploration behavior), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:1990089 (response to nerve growth factor), GO:0007612 (learning), GO:0014070 (response to organic cyclic compound), GO:0042542 (response to hydrogen peroxide), GO:0031345 (negative regulation of cell projection organization), GO:0000302 (response to reactive oxygen species), GO:0071363 (cellular response to growth factor stimulus), GO:0043279 (response to alkaloid), GO:0099175 (regulation of postsynapse organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010977 (negative regulation of neuron projection development), GO:1990090 (cellular response to nerve growth factor stimulus), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098978 (glutamatergic synapse), GO:0005634 (nucleus)