Protein: Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) (P00813)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:8101391}; Peripheral membrane protein; Extracellular side. Cell junction {ECO:0000269|PubMed:11772392}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000269|PubMed:8452534}. Note=Colocalized with DPP4 at the cell surface. {ECO:0000269|PubMed:11772392}.
Sequence: MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL
InterPro domains: - IPR001365: Adenosine deaminase domain (domain) [10-349]
- IPR006650: Adenosine/AMP deaminase active site (active_site) [291-297]
- IPR028893: Adenosine deaminase (family) [4-348]
- IPR032466: Metal-dependent hydrolase (homologous_superfamily) [6-348]
- IPR006330: Adenosine/adenine deaminase (family) [8-354]
Interaction partners: - Dipeptidyl peptidase 4
- Purine nucleoside phosphorylase
- Adenosine deaminase 2
- Adenosine kinase
- 5'-nucleotidase
- Double-stranded RNA-specific adenosine deaminase
- Deoxycytidine kinase
- 5'
- 5'
- Cytosolic purine 5'-nucleotidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0019239 (deaminase activity), GO:0042803 (protein homodimerization activity), GO:0046872 (metal ion binding), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0046914 (transition metal ion binding), GO:0004000 (adenosine deaminase activity), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044282 (small molecule catabolic process), GO:0060548 (negative regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0009410 (response to xenobiotic stimulus), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006805 (xenobiotic metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:1901565 (organonitrogen compound catabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:0019439 (aromatic compound catabolic process), GO:0009116 (nucleoside metabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0019693 (ribose phosphate metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901657 (glycosyl compound metabolic process), GO:0034656 (nucleobase-containing small molecule catabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046434 (organophosphate catabolic process), GO:0009261 (ribonucleotide catabolic process), GO:0072523 (purine-containing compound catabolic process), GO:0042981 (regulation of apoptotic process), GO:0009117 (nucleotide metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0043066 (negative regulation of apoptotic process), GO:0009164 (nucleoside catabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:1901292 (nucleoside phosphate catabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:1901292 (nucleoside phosphate catabolic process), GO:1901658 (glycosyl compound catabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0042278 (purine nucleoside metabolic process), GO:0009119 (ribonucleoside metabolic process), GO:0009125 (nucleoside monophosphate catabolic process), GO:0009154 (purine ribonucleotide catabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009166 (nucleotide catabolic process), GO:0006195 (purine nucleotide catabolic process), GO:0009151 (purine deoxyribonucleotide metabolic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0009113 (purine nucleobase biosynthetic process), GO:0009165 (nucleotide biosynthetic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0006152 (purine nucleoside catabolic process), GO:0009167 (purine ribonucleoside monophosphate metabolic process), GO:0046033 (AMP metabolic process), GO:0046040 (IMP metabolic process), GO:0009128 (purine nucleoside monophosphate catabolic process), GO:0009127 (purine nucleoside monophosphate biosynthetic process), GO:0009156 (ribonucleoside monophosphate biosynthetic process), GO:0009158 (ribonucleoside monophosphate catabolic process), GO:0009169 (purine ribonucleoside monophosphate catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)