Protein: Beta-site APP-cleaving enzyme, isoform A (Beta-site APP-cleaving enzyme, isoform B (EC 3.4.23.-)) (GH11417p) (Q9VLK3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MFKTIAVVVLLAALASAELHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLRSVDEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDDCQAIADTGTSLIVAPYNAYITLSEILNVGEDGYLDCSSVSSLPDVTFNIGGTNFVLKPSAYIIQSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFAPVA
InterPro domains: - IPR033121: Peptidase family A1 domain (domain) [68-371]
- IPR001969: Aspartic peptidase, active site (active_site) [84-278]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [7-371]
- IPR001461: Aspartic peptidase A1 (family) [17-369]
Interaction partners: - Cathepsin B, isoform A)
- cathepsin L
- Cathepsin L1
- FI04419p
- Cathepsin F
- Amyloid-beta-like protein
- Trypsin alpha
- RH58587p
- Presenilin homolog
- Vacuolar protein sorting-associated protein 35
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0006950 (response to stress), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0051707 (response to other organism), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1902742 (apoptotic process involved in development), GO:0012501 (programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009617 (response to bacterium), GO:0010623 (programmed cell death involved in cell development), GO:0006952 (defense response), GO:0098542 (defense response to other organism), GO:0007292 (female gamete generation), GO:0042742 (defense response to bacterium), GO:0006915 (apoptotic process), GO:0048477 (oogenesis), GO:0050829 (defense response to Gram-negative bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)