Protein: White-opaque regulator 2 (Q5ANB1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MTQLPSVSELINRTGSIGSSSNITRVPPMTTTSATNTTTAATATTVTSTTPRSENSYSPNSPYSLPTRPSNTSLTNYSAGSGITVASSSFQFSQPSPGRSKHNSTSSQSSSGDSFQQHQSNPSGVSMSSNTSPRTSIVQSMSSVPTPPSTGPAPQQFVYQESQLPVQPPPQQQQLQQPPPPPPQQQQHIYPQQQPNFPYHNNFVSPPTYTTAYPQYYYQPVMTPPHHQPHQQAPIHLANNVSILQSQAVMQNAYPTTHYLQHVGPHHIYANVNSQVYYQDMAREEANKALINKRRIIKRRTRTGCLTCRKRRIKCDERKPTCFNCERSKKSCLGYQDLSKLPPRKRNRDTSLDLPDGNQQQQQQQQNQQSIVGGAGNVSDEPHNETHQITSISGSSTNSRNLDMMIPQSFRNNISSQPINFYGPVATTASGASAVINRVSVADLLK
InterPro domains: - IPR036864: Zn(2)-C6 fungal-type DNA-binding domain superfamily (homologous_superfamily) [296-369]
- IPR001138: Zn(2)Cys(6) fungal-type DNA-binding domain (domain) [299-343]
- IPR052360: Transcriptional Regulatory Proteins (family) [197-373]
Interaction partners: - White-opaque regulator 1
- White-opaque regulator 3
- Wor4p
- Enhanced filamentous growth protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0007584 (response to nutrient), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0071496 (cellular response to external stimulus), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0031670 (cellular response to nutrient), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0031669 (cellular response to nutrient levels), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)