Protein: Elongator complex protein 5 (Q24050)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Binding by the elongator complex stabilizes microtubules and promotes their growth. This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During asymmetric cell division of sensory organ precursor cells the elongator complex preferentially binds and stabilizes microtubules on the anterior side (pIIb daughter cell) of the spindle
Sequence: MLSNLVVTKQKVVLVIDELNRERIAPKFIGSLLHEQGQGADTIKALPTGVSLKHVATFEALIDKYANNNTGSTTDSNSTGFNVILPTLADLLCYQTPAFIFGFLNRLRRSDNVRRVFLWASPQHLQDPHADYILAGCEYLAELVLRLESDKLLSLISRKPGGGVSNRRYSCEVSKTQFKVTPLDGGLPAGASPKQPSPEAEQTTEPASSTFKIELDEDEVLARNALTLPYERTSEPSEGNIIYTPDADDDFDEEDPDEDLCI
InterPro domains: - IPR019519: Elongator complex protein 5 (family) [55-262]
Interaction partners: - Elongator complex protein 1
- Elongator complex protein 3
- Elongator complex protein 2
- Elongator complex protein 4
- Elongator complex protein 6
- Tetraspanin 68C, isoform A
- RE67794p
- Protein KTI12 homolog
- Cytoplasmic tRNA 2-thiolation protein 1
- Adenylyltransferase and sulfurtransferase MOCS3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0006807 (nitrogen compound metabolic process), GO:0050877 (nervous system process), GO:0006725 (cellular aromatic compound metabolic process), GO:0030534 (adult behavior), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0007611 (learning or memory), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0009112 (nucleobase metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0019674 (NAD metabolic process), GO:0006734 (NADH metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex)