Protein: Chloride channel protein (D4A3H5)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
Sequence: MAGCRGSVCCCCRWCCCCGERESRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRHEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTCILSTAPLFQTLGFSRLFLPVAAGSGIPEIKCYLNGVKVPGIVRLRTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGAFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFCPNDTYNDMATLFFNSQESAILQLFHQDGTFSPVTLALFFALYFLMACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHIGLRGVPLLEWETEVEMDRLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTTEFLQARLRQHYQTL
InterPro domains: - IPR001807: Chloride channel (family) [130-573]
- IPR014743: Chloride channel, core (homologous_superfamily) [71-575]
- IPR002248: Chloride channel ClC-6 (family) [2-110]
- IPR046342: CBS domain superfamily (homologous_superfamily) [575-850]
- IPR051280: Voltage-gated chloride channel/antiporter (family) [17-841]
- IPR000644: CBS domain (domain) [585-852]
Interaction partners: - Osteoclastogenesis associated transmembrane protein 1
- Inositol polyphosphate 5-phosphatase OCRL
- Mediator of RNA polymerase II transcription subunit 19
- U4/U6 small nuclear ribonucleoprotein Prp3
- Glucose-6-phosphate 1-dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0040017 (positive regulation of locomotion), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0019538 (protein metabolic process), GO:0006810 (transport), GO:0044249 (cellular biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0034220 (monoatomic ion transmembrane transport), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0071705 (nitrogen compound transport), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:0071702 (organic substance transport), GO:0030334 (regulation of cell migration), GO:0034645 (cellular macromolecule biosynthetic process), GO:0030334 (regulation of cell migration), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0044264 (cellular polysaccharide metabolic process), GO:0006821 (chloride transport), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006821 (chloride transport), GO:0003712 (transcription coregulator activity), GO:0000082 (G1/S transition of mitotic cell cycle), GO:0015711 (organic anion transport), GO:1902476 (chloride transmembrane transport), GO:0034645 (cellular macromolecule biosynthetic process), GO:0030334 (regulation of cell migration), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)