wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Adhesion G-protein coupled receptor F1 (G protein-coupled receptor 110) (G protein-coupled receptor KPG_012) (G protein-coupled receptor PGR19) (Q5T601)
Organism: Homo sapiens (Human)
Function: Orphan receptor.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20149256}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:20149256}.
Sequence: MKVGVLWLISFFTFTDGHGGFLGKNDGIKTKKELIVNKKKHLGPVEEYQLLLQVTYRDSKEKRDLRNFLKLLKPPLLWSHGLIRIIRAKATTDCNSLNGVLQCTCEDSYTWFPPSCLDPQNCYLHTAGALPSCECHLNNLSQSVNFCERTKIWGTFKINERFTNDLLNSSSAIYSKYANGIEIQLKKAYERIQGFESVQVTQFRNGSIVAGYEVVGSSSASELLSAIEHVAEKAKTALHKLFPLEDGSFRVFGKAQCNDIVFGFGSKDDEYTLPCSSGYRGNITAKCESSGWQVIRETCVLSLLEELNKNFSMIVGNATEAAVSSFVQNLSVIIRQNPSTTVGNLASVVSILSNISSLSLASHFRVSNSTMEDVISIADNILNSASVTNWTVLLREEKYASSRLLETLENISTLVPPTALPLNFSRKFIDWKGIPVNKSQLKRGYSYQIKMCPQNTSIPIRGRVLIGSDQFQRSLPETIISMASLTLGNILPVSKNGNAQVNGPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFSHLQWNDAGCHLVNETQDIVTCQCTHLTSFSILMSPFVPSTIFPVVKWITYVGLGISIGSLILCLIIEALFWKQIKKSQTSHTRRICMVNIALSLLIADVWFIVGATVDTTVNPSGVCTAAVFFTHFFYLSLFFWMLMLGILLAYRIILVFHHMAQHLMMAVGFCLGYGCPLIISVITIAVTQPSNTYKRKDVCWLNWSNGSKPLLAFVVPALAIVAVNFVVVLLVLTKLWRPTVGERLSRDDKATIIRVGKSLLILTPLLGLTWGFGIGTIVDSQNLAWHVIFALLNAFQGFFILCFGILLDSKLRQLLFNKLSALSSWKQTEKQNSSDLSAKPKFSKPFNPLQNKGHYAFSHTGDSSDNIMLTQFVSNE
InterPro domains: - IPR008078: GPCR family 2, Ig-hepta-like receptor (family) [254-870]
- IPR000832: GPCR, family 2, secretin-like (family) [585-841]
- IPR000082: SEA domain (domain) [148-256]
- IPR046338: GAIN domain superfamily (homologous_superfamily) [436-576]
- IPR051587: Adhesion G-protein coupled receptor (family) [249-899]
- IPR057244: GAIN, subdomain B (domain) [437-579]
- IPR000203: GPS motif (conserved_site) [530-578]
- IPR017981: GPCR, family 2-like, 7TM (domain) [585-842]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Probable non-functional immunoglobulin heavy variable 3-16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: FI06026p (A1ZBR1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MLPNWLTEEYLQPKLRAYYKDDQLKVVKVWAKPATEKGQNYMSLMTRIHVEIQQGDGLLQNRTYIIKESLSEDCPQAKVFLEYDVYNREMDMYEFILPKMNELLQEVGLTGKFTADTIFVDREYRTIILEDLAQYNYVNADRVKQLDLAHTKLTLEVLAKFHAASIVVKQRHPELLTKSLFIHCFSRDNKGYTEVYEGVLSAFIRFINEQPVLKKKYGNKLQKIHENIMDYGARTFEVGEQELLTLSHGDCWTTNFLYQYDDASNPQSAVAIDFQFSNFTSPVNDLHQFFTVSLRDEVQDMESVLVEKYYSDLKTNVDTLSYKGIFPSLQGFQKQFESRRFMCLLAHLFKPVIIYDGTEVSSDFSSVYKDTEEGIRFQKAIYANERVLKSATKLLAMLDAKGVLNLQ
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [3-356]
- IPR004119: Ecdysteroid kinase-like (family) [37-322]
- IPR015897: CHK kinase-like (domain) [127-319]
Interaction partners: - GEO12048p1
- Uncharacterized protein
- Protein crossbronx-like
- FI17342p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0106389 (ecdysteroid 22-kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055070 (copper ion homeostasis), GO:0055080 (monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Cornichon protein (Q381F1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MGILQHQADVWHALRYPSKHSWGERKRAYLFVFAYCLAAIALFASVMHFIGAWIACGLLQVIMLIFAMLFALNIADCRDKCLNVLECERAINPVMEVYIGLRFIQFLHATFLLTNIPMGVSILVALLYSLWRMWCGTYFVDATSLWREVGRLERDSYIHICIEIALIVIYLIAIVFAMVDKYS
InterPro domains: - IPR003377: Cornichon (family) [50-172]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Oil body-associated protein 1B (Q8GWR2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MEKAVHSSTTSGPAVPGETTKTGTSIIDTAASAVQSFAPVNQIHQHLCAFHFYADDMARQVEAHHFCSHVNEEMRQCLIYDGPDANARLIGLEYIVSEKLFMTLPDEEKKLWHSHEWEVKGGFLFMPGVPGAIQRKDLDKVAKTYGKVFHFWQVDLGHELPIGLPNVMMAVTRDGQLFHEMIQEAEKRFGVSVEGERDSRAYMSGPELGIHPLANGGGKGMKLELREVDIKPVESVGSVFV
InterPro domains: - IPR010686: Oil body-associated protein-like (family) [6-234]
Interaction partners: - Oil body-associated protein 2C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051235 (maintenance of location), GO:0071840 (cellular component organization or biogenesis), GO:0003006 (developmental process involved in reproduction), GO:0033036 (macromolecule localization), GO:0009791 (post-embryonic development), GO:0010876 (lipid localization), GO:0048316 (seed development), GO:0044085 (cellular component biogenesis), GO:0019915 (lipid storage), GO:0048731 (system development), GO:0009790 (embryo development), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0009793 (embryo development ending in seed dormancy), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0061458 (reproductive system development), GO:0097305 (response to alcohol), GO:0033993 (response to lipid), GO:0009737 (response to abscisic acid), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)
Protein: Eyes absent homolog (EC 3.1.3.48) (D3ZHX6)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
InterPro domains: - IPR038102: EYA domain superfamily (homologous_superfamily) [256-496]
- IPR028472: Protein phosphatase EYA (family) [285-492]
- IPR036412: HAD-like superfamily (homologous_superfamily) [258-482]
- IPR006545: EYA domain (domain) [284-496]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0048513 (animal organ development), GO:0048839 (inner ear development), GO:0007423 (sensory organ development), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein DVR-1 (P35621)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.
Subcellular location: Secreted {ECO:0000250}.
Sequence: MFLVLLRACLLTLSLCSPAEDDGLVQEKLFLSSMGLWSRPKPSHHAAVPSQMWKIFKQASKQTVNDPCVVSEYGVRGNIVRFMQDQGSLISAPAVHSFNCVRKHLFFNMSVLEEVEQLSLAQLEMKFKQDLLLLGPHVFSVDLYRVLKTTLKGVTHESSRKLLQSQTLSPGAHASVLVNLTNLAQSWRKPEKNFGMQLELQVMHLNNMLHDHAYVQIPDIHATLVVVSLNPLQCRSRRKRSASYYLPVTPSNVCKPRRLYIDFKDVGWQDWIIAPQGYLANYCHGECPFPLSESLNGTNHAILQTLVHSFDPKGTPQPCCVPIKLSPISMLYYDNNDNVVLRHYEDMVVDECGCR
InterPro domains: - IPR015615: Transforming growth factor-beta-related (family) [27-355]
- IPR001839: Transforming growth factor-beta, C-terminal (domain) [237-355]
- IPR001111: TGF-beta, propeptide (domain) [28-201]
- IPR017948: Transforming growth factor beta, conserved site (conserved_site) [272-287]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [248-355]
Interaction partners: - Receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Receptor protein serine/threonine kinase
- Serine/threonine-protein kinase receptor
- Serine/threonine-protein kinase receptor
- receptor protein serine/threonine kinase
- Teratocarcinoma-derived growth factor 1
- POU domain, class 5, transcription factor 1
- Spalt-like transcription factor 2.
- Left-right determination factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0031128 (developmental induction), GO:0007389 (pattern specification process), GO:0009799 (specification of symmetry), GO:0060061 (Spemann organizer formation), GO:0003002 (regionalization), GO:0009855 (determination of bilateral symmetry), GO:0009953 (dorsal/ventral pattern formation), GO:0048264 (determination of ventral identity), GO:0048262 (determination of dorsal/ventral asymmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: CD164 sialomucin-like 2 protein (Q6UWJ8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MEAPGPRALRTALCGGCCCLLLCAQLAVAGKGARGFGRGALIRLNIWPAVQGACKQLEVCEHCVEGDGARNLSSCVWEQCRPEEPGHCVAQSEVVKEGCSIYNRSEACPAAHHHPTYEPKTVTTGSPPVPEAHSPGFDGASFIGGVVLVLSLQAVAFFVLHFLKAKDSTYQTLI
InterPro domains: - IPR007947: CD164-related protein (family) [1-173]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007155 (cell adhesion), GO:0006955 (immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005773 (vacuole), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030667 (secretory granule membrane), GO:0005774 (vacuolar membrane), GO:0042582 (azurophil granule), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0035577 (azurophil granule membrane), GO:0098852 (lytic vacuole membrane), GO:0005766 (primary lysosome), GO:0005765 (lysosomal membrane)
Protein: Nucleolar protein 10 (D3ZMP6)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRHRITIKKRFKVLMTQQPRPVL
InterPro domains: - IPR007264: H/ACA ribonucleoprotein complex, subunit Nop10 (family) [1-63]
- IPR036756: H/ACA ribonucleoprotein complex, subunit Nop10 superfamily (homologous_superfamily) [3-58]
Interaction partners: - H/ACA ribonucleoprotein complex subunit 1
- Ribonucloprotein
- Ribonucloprotein
- H/ACA ribonucleoprotein complex subunit DKC1
- Telomerase Cajal body protein 1
- Telomerase reverse transcriptase
- NHP2-like protein 1
- Nucleolar protein 56
- H/ACA ribonucleoprotein complex non-core subunit NAF1
- Nucleolar protein 58
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0010467 (gene expression), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0034470 (ncRNA processing), GO:0000154 (rRNA modification), GO:0001522 (pseudouridine synthesis), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0000469 (cleavage involved in rRNA processing), GO:0016072 (rRNA metabolic process), GO:0016073 (snRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Peroxidase (EC 1.11.1.7) (Q8RVP3)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Not known
Subcellular location: Secreted {ECO:0000256|RuleBase:RU362060}.
Sequence: MPEKMACFQYIVAALCFAVLLEGSLSKAQLTPTFYDETCPNVTAIIRHVLVNASFSDPRIGASLIRLHFHDCFVQGCDASILLDDPVNGEKEAIPNNNSARGYEVIDAMKAALESACPNTVSCADILAIASEQSVSTLAGGPSWAVPLGRRDGFTANRTLANSNLPGFNNTLDRLKNRFSNVGLNTSIDLVALSGAHTFGRAQCLTFTSRLYNFTGVGDTDPTLNATYLEELRQICPQGGNSSVLTNLDPTTPDGFDNNYFTNLQVNRGLLRSDQNLFSTEGADTIEIVNRFSSNQTAFFESFVESMIRMGNISPLTGTEGEIRSNCRAVNSATIRSNSDAALVSSI
InterPro domains: - IPR010255: Haem peroxidase superfamily (homologous_superfamily) [29-331]
- IPR019794: Peroxidase, active site (active_site) [61-72]
- IPR019793: Peroxidases heam-ligand binding site (binding_site) [189-199]
- IPR002016: Haem peroxidase (domain) [29-331]
- IPR033905: Secretory peroxidase (domain) [29-330]
- IPR000823: Plant peroxidase (family) [28-330]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004601 (peroxidase activity), GO:0016491 (oxidoreductase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0009505 (plant-type cell wall)
Protein: Phosphothreonine lyase OspF (EC 4.2.3.-) (Effector protein OspF) (Q8VSP9)
Organism: Shigella flexneri
Function: Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of pro-inflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host.
Subcellular location: Secreted {ECO:0000269|PubMed:11115111, ECO:0000269|PubMed:16988276, ECO:0000269|PubMed:17159983, ECO:0000269|PubMed:17305427}. Note=Secreted via the type III secretion system (T3SS). Localizes in the nucleus of the infected cell.
Sequence: MPIKKPCLKLNLDSLNVVRSEIPQMLSANERLKNNFNILYNQIRQYPAYYFKVASNVPTYSDICQSFSVMYQGFQIVNHSGDVFIHACRENPQSKGDFVGDKFHISIAREQVPLAFQILSGLLFSEDSPIDKWKITDMNRVSQQSRVGIGAQFTLYVKSDQECSQYSALLLHKIRQFIMCLESNLLRSKIAPGEYPASDVRPEDWKYVSYRNELRSDRDGSERQEQMLREEPFYRLMIE
InterPro domains: - IPR038498: OspF/SpvC superfamily (homologous_superfamily) [22-239]
- IPR003519: OspF/SpvC (family) [2-239]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0097747 (RNA polymerase activity), GO:0016779 (nucleotidyltransferase activity), GO:0034062 (5'-3' RNA polymerase activity), GO:0003899 (DNA-directed 5'-3' RNA polymerase activity), GO:0003896 (DNA primase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050792 (regulation of viral process), GO:0046782 (regulation of viral transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Ubiquinone biosynthesis O-methyltransferase, mitochondrial (3-demethylubiquinol 3-O-methyltransferase) (EC 2.1.1.64) (Polyprenyldihydroxybenzoate methyltransferase) (EC 2.1.1.114) (E1JHN2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|HAMAP-Rule:MF_03190}; Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_03190}; Matrix side {ECO:0000256|HAMAP-Rule:MF_03190}.
Sequence: MMRNALLVSGKLRHLLSCSIGRNSTRSSSTAKSLDAGTQKEVRHHENHASEWWNQNGTMGALHALNEIRVPFIRDGIVSRGTVKPGYVNTTKVLLGQNILEVGCGGGLLTEHLARLGAQVAGIDLGEKLIEAAREHLKCSSPELASNVVYKIEPVDQHAKANCECYDAVIVSEVLEHVKDKVSLLEASVRSLKPGGSIFITTLNKTIPSWFGGVLLSEYVLNLVPRGTHHWDKMISPLDVQRILDTMNCQTVLVNGSTYDFWSNTWRWINNNQMCYALQAVKQAQREYN
InterPro domains: - IPR013216: Methyltransferase type 11 (domain) [100-200]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [41-283]
- IPR010233: Ubiquinone biosynthesis O-methyltransferase (family) [41-283]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009611 (response to wounding), GO:0042060 (wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)