Protein: Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1) (E5FYH1)
Organism: Mus musculus (Mouse)
Function: Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22069478}.
Sequence: MRPPATPPDPTKEPGCKGTTRGLRKRGLPLTPEPGEGGGCSLEARGCEEESRQKQRMVTQASGREETEGDKLAKENGKITEAPSDDPQPGTDLVRKTSITSSESLQTVECSEFQNMAFLQSLDKEELGEGIKRRMRIKKCKSLENPPLEITKNEATQNIKVEFQDELFKNTPKHSCNSLSPGVEKNCSFELHDYSFLHSEGCNNENNFEDKPHDVCLHTEENSLKLKKENLRNLAEKDDTRTTTKLLKTEKSVIASKLLLEESHLYQNKNNGLTSCLQSEKNKYSVEENNTGRKHRKKMKSGKEEKNINLTLSNVCNNSVLVLQENQMGMEGKEAETLEPKKSFLKALRKINHNTLPPVDHLCLPKTVGKTSSRHHINAMLQKTLESSLKEDIKNTSESLGCKRIEPEKYNKSMISSTVKSPSDGHHMEKRSPRGDLRSETEESKVSCCRTIPMTGKRVWPFYSCARISAQCWKKTSLSDLNYSLLGPLENVRQHDSIIHQMNQTHLPDSKLLQPSLTERTTESSRKEMYDSDLSCLSSVSSVESTVMDIKEAMSHDKKTKLEEPSRNGAEVVSNATEDTQLSNITQSLTGNKKRKGNLSKLNLTVASQESQETNNCANKTVHRKVCITKQTLVAPDLVKILNTGRLTNFKIPLLKNKTGKRGAVSARSSEREAYSPLELLDSLSGVEAKQNRNKENICTTSGPQSLNLHSCIAPGQASSHSFYNKNSCTSSSFTKKGYDNKACNHISEPGNIISNKESISMKIENNTFSCDLGYIDQSSFCSKKQEAFVPISSEISGRKMTKSISELKLGFPDILKAYEDDVLLIDVIQDDPELFGISSEGDLSFASEVSKISQEPRVSEDQPTADFKHMHLPGKKEPGDLSKEVALLDPGLLKLESCPSLSAAKEPQHDPEGAAISLEATEETVVSGSLEGLSEQARASDSDAKCISSDKATVMEEQESTHEIFKSKDSRNVESATECQLATLGPNPLCSSALPVNLSSHQDVVSTPWINDVRFPGRHSVLQLQNPETCEIFKREKNMGVFQKPLGLLIPHRYCKLHFNTLRGCERAQCKFVHVPEQGDEKICMDVFRKYISVNEQRLLHRAAYIFLEYYRKFPPGIHFSLQVLNDLLISLLKHCLLKEVFQVVQLSIMAKMLPALKILLKIFEYVAAMKLRNAVPALIEIFCKFIEAGMVPDPEHLNYIVKLLHQAQASQQEISAVLQAKSRLRVRQLKKNWKCDLDSALSEVETCKEKSDWTKLGNLYISIKMSCEEFADLQRFCACVAETLTEDYKEERPGVPFCEFAETVSKDPQYSEVDKTLLGRIGISAVYFYHRLLLWAKGRKVLDILYELKIHFTSLKGLTGPEKEAPRCQIVNVAAEIFIKSGSLDGAIWVLRESEWIINTPLWPCDRMDVLNRHNLLCTIAHEILGKNLYKQTFEVLRNLPSFQNSQEMMGVSQSSLLFNELLDACIESNSLGISSSVAEFMVAKSIPIDFSFLRRLITSLGRSCLWLKARAHYKSALSLGCYPPLEGNLHRKLLLVPSYLSEIEMLLAMEIFLVSNASGIQSAGMGAPTQVLQIVLKRCEESKSRSKDEYQAAVERLVMAARISDPKLFIKHMTVNINKEQVYSLEHCSALKWLKENMKWAGKVWLFTNH
InterPro domains: - IPR029435: Protein TOPAZ1 domain (domain) [1246-1421]
- IPR038952: Protein TOPAZ1 (family) [1-1650]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)