Protein: Peroxiredoxin-1 (EC 1.11.1.24) (Macrophage 23 kDa stress protein) (Osteoblast-specific factor 3) (OSF-3) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1) (P35700)
Organism: Mus musculus (Mouse)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q06830}.
Sequence: MSSGNAKIGYPAPNFKATAVMPDGQFKDISLSEYKGKYVVFFFYPLDFTFVCPTEIIAFSDRADEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLISDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEIIRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK
InterPro domains: - IPR024706: Peroxiredoxin, AhpC-type (family) [1-199]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [7-197]
- IPR013766: Thioredoxin domain (domain) [6-165]
- IPR019479: Peroxiredoxin, C-terminal (domain) [162-197]
- IPR000866: Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant (domain) [8-141]
- IPR050217: Thiol-specific antioxidant peroxiredoxin (family) [5-198]
Interaction partners: - Sulfiredoxin-1
- Thioredoxin
- Peroxiredoxin-5, mitochondrial
- Tyrosine-protein kinase ABL1
- Thioredoxin, mitochondrial
- Cyclin-dependent kinase 5
- Thioredoxin reductase 1, cytoplasmic
- Peroxiredoxin-2
- Glutathione peroxidase 1
- Cyclin-dependent kinase 5 activator 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004601 (peroxidase activity), GO:0016491 (oxidoreductase activity), GO:0005515 (protein binding), GO:0051920 (peroxiredoxin activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor), GO:0140824 (thioredoxin-dependent peroxiredoxin activity), GO:0008379 (thioredoxin peroxidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0098754 (detoxification), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:1900048 (positive regulation of hemostasis), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:1900046 (regulation of hemostasis), GO:0002532 (production of molecular mediator involved in inflammatory response), GO:0001776 (leukocyte homeostasis), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:1990748 (cellular detoxification), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0002520 (immune system development), GO:0045730 (respiratory burst), GO:0002252 (immune effector process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0050818 (regulation of coagulation), GO:0002260 (lymphocyte homeostasis), GO:0009968 (negative regulation of signal transduction), GO:0002695 (negative regulation of leukocyte activation), GO:0012501 (programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0060548 (negative regulation of cell death), GO:0072593 (reactive oxygen species metabolic process), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0042743 (hydrogen peroxide metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002694 (regulation of leukocyte activation), GO:0030193 (regulation of blood coagulation), GO:1903706 (regulation of hemopoiesis), GO:0046649 (lymphocyte activation), GO:1903707 (negative regulation of hemopoiesis), GO:0050820 (positive regulation of coagulation), GO:0010035 (response to inorganic substance), GO:0050878 (regulation of body fluid levels), GO:0050866 (negative regulation of cell activation), GO:0070661 (leukocyte proliferation), GO:0007162 (negative regulation of cell adhesion), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:1901575 (organic substance catabolic process), GO:0050865 (regulation of cell activation), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0006979 (response to oxidative stress), GO:0044092 (negative regulation of molecular function), GO:0009636 (response to toxic substance), GO:0030194 (positive regulation of blood coagulation), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:1903036 (positive regulation of response to wounding), GO:0010033 (response to organic substance), GO:0048872 (homeostasis of number of cells), GO:0002831 (regulation of response to biotic stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0098869 (cellular oxidant detoxification), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0045596 (negative regulation of cell differentiation), GO:0009617 (response to bacterium), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0048534 (hematopoietic or lymphoid organ development), GO:0032102 (negative regulation of response to external stimulus), GO:0034599 (cellular response to oxidative stress), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0022407 (regulation of cell-cell adhesion), GO:0048732 (gland development), GO:0002237 (response to molecule of bacterial origin), GO:0019430 (removal of superoxide radicals), GO:0048538 (thymus development), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:1901099 (negative regulation of signal transduction in absence of ligand), GO:0097237 (cellular response to toxic substance), GO:0090303 (positive regulation of wound healing), GO:1902105 (regulation of leukocyte differentiation), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0022408 (negative regulation of cell-cell adhesion), GO:1901701 (cellular response to oxygen-containing compound), GO:0051249 (regulation of lymphocyte activation), GO:0046651 (lymphocyte proliferation), GO:0032496 (response to lipopolysaccharide), GO:1902106 (negative regulation of leukocyte differentiation), GO:0010310 (regulation of hydrogen peroxide metabolic process), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:1903034 (regulation of response to wounding), GO:0042744 (hydrogen peroxide catabolic process), GO:0062197 (cellular response to chemical stress), GO:0060284 (regulation of cell development), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:0032943 (mononuclear cell proliferation), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0000305 (response to oxygen radical), GO:0006954 (inflammatory response), GO:0033993 (response to lipid), GO:0006801 (superoxide metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006915 (apoptotic process), GO:0043029 (T cell homeostasis), GO:0042110 (T cell activation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0031664 (regulation of lipopolysaccharide-mediated signaling pathway), GO:0097191 (extrinsic apoptotic signaling pathway), GO:0010721 (negative regulation of cell development), GO:0000302 (response to reactive oxygen species), GO:1902531 (regulation of intracellular signal transduction), GO:0042981 (regulation of apoptotic process), GO:0045619 (regulation of lymphocyte differentiation), GO:0050863 (regulation of T cell activation), GO:2001141 (regulation of RNA biosynthetic process), GO:0042098 (T cell proliferation), GO:0000303 (response to superoxide), GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:0043410 (positive regulation of MAPK cascade), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:0034614 (cellular response to reactive oxygen species), GO:0071450 (cellular response to oxygen radical), GO:0061041 (regulation of wound healing), GO:0043408 (regulation of MAPK cascade), GO:2001239 (regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:0043066 (negative regulation of apoptotic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045620 (negative regulation of lymphocyte differentiation), GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:0050868 (negative regulation of T cell activation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045581 (negative regulation of T cell differentiation), GO:0071451 (cellular response to superoxide), GO:0045580 (regulation of T cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043209 (myelin sheath), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)