Protein: ATP-dependent zinc metalloprotease FTSH 5, chloroplastic (AtFTSH5) (EC 3.4.24.-) (Protein VARIEGATED 1) (Q9FH02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Part of a complex that function as an ATP-dependent zinc metallopeptidase. Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions. Not involved in the degradation of the light-harvesting complex of photosystem II (LHC II) or in thermotolerance.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:12167156, ECO:0000269|PubMed:14630971, ECO:0000269|PubMed:18431481}; Single-pass membrane protein {ECO:0000269|PubMed:12167156, ECO:0000269|PubMed:14630971}; Stromal side {ECO:0000269|PubMed:12167156, ECO:0000269|PubMed:14630971}.
Sequence: MATTSSNPLLLSSNFLGSQIIISAPTPKTTTKSLPFSVISRKRYQISQSEKLMKSLPSQAALAALLFSSSSPQALAVNEPVQPPAPTITAEAQSPNLSTFGQNVLMTAPNPQAQSSDLPDGTQWRYSEFLNAVKKGKVERVKFSKDGSVLQLTAVDNRRATVIVPNDPDLIDILAMNGVDISVSEGEGGNGLFDFIGNLLFPLLAFGGLFYLFRGGQGGAGGPGGLGGPMDFGRSKSKFQEVPETGVTFGDVAGADQAKLELQEVVDFLKNPDKYTALGAKIPKGCLLVGPPGTGKTLLARAVAGEAGVPFFSCAASEFVELFVGVGASRVRDLFEKAKSKAPCIVFIDEIDAVGRQRGAGMGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATNRPDVLDSALLRPGRFDRQVTVDRPDVAGRVQILKVHSRGKAIGKDVDYEKVARRTPGFTGADLQNLMNEAAILAARRELKEISKDEISDALERIIAGPEKKNAVVSEEKKRLVAYHEAGHALVGALMPEYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALGGRVAEEVIFGDENVTTGASNDFMQVSRVARQMVERFGFSKKIGQVAVGGAGGNPFLGQSMSSQKDYSMATADVVDAEVRELVEKAYVRAKEIITTQIDILHKLAQLLIEKETVDGEEFMSLFIDGQAELYVS
InterPro domains: - IPR000642: Peptidase M41 (domain) [500-692]
- IPR003593: AAA+ ATPase domain (domain) [282-421]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [441-484]
- IPR003959: ATPase, AAA-type, core (domain) [286-418]
- IPR037219: Peptidase M41-like (homologous_superfamily) [496-699]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [237-490]
- IPR005936: ATP-dependent zinc metalloprotease, FtsH (family) [7-704]
- IPR003960: ATPase, AAA-type, conserved site (conserved_site) [389-407]
Interaction partners: - ATP-dependent zinc metalloprotease FTSH 8, chloroplastic
- Zinc finger protein VAR3, chloroplastic
- Protease Do-like 1, chloroplastic
- Translation initiation factor IF-2
- ATP-dependent Clp protease proteolytic subunit 3, chloroplastic
- AT5g02160
- Protease Do-like 5, chloroplastic
- Protease Do-like 8, chloroplastic
- ATP-dependent Clp protease proteolytic subunit-related protein 3, chloroplastic
- Protein THYLAKOID FORMATION 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015979 (photosynthesis), GO:0009057 (macromolecule catabolic process), GO:0030091 (protein repair), GO:0009765 (photosynthesis, light harvesting), GO:1901565 (organonitrogen compound catabolic process), GO:0030163 (protein catabolic process), GO:0019684 (photosynthesis, light reaction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031977 (thylakoid lumen), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0043227 (membrane-bounded organelle), GO:0009507 (chloroplast), GO:0042651 (thylakoid membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0031968 (organelle outer membrane), GO:0009941 (chloroplast envelope), GO:0009579 (thylakoid), GO:0055035 (plastid thylakoid membrane), GO:0005634 (nucleus), GO:0009535 (chloroplast thylakoid membrane), GO:0009534 (chloroplast thylakoid)