Protein: Transcription factor SOX-4 (Q06831)
Organism: Mus musculus (Mouse)
Function: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression. Involved in skeletal myoblast differentiation by promoting gene expression of CALD1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q06945}.
Sequence: MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHMADYPDYKYRPRKKVKSGNAGAGSAATAKPGEKGDKVAGSSGHAGSSHAGGGAGGSSKPAPKKSCGPKVAGSSVGKPHAKLVPAGGSKAAASFSPEQAALLPLGEPTAVYKVRTPSAATPAASSSPSSALATPAKHPADKKVKRVYLFGSLGASASPVGGLGASADPSDPLGLYEDGGPGCSPDGRSLSGRSSAASSPAASRSPADHRGYASLRAASPAPSSAPSHASSSLSSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY
InterPro domains: - IPR009071: High mobility group box domain (domain) [58-128]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [49-134]
- IPR050140: SRY-related HMG-box transcription factor-like (family) [20-419]
- IPR017386: Transcription factor SOX-12/11/4 (family) [1-440]
Interaction partners: - POU domain, class 5, transcription factor 1
- Catenin beta-1
- Lymphoid enhancer-binding factor 1
- Histone-lysine N-methyltransferase EZH2
- Transcription factor 7-like 1
- Trans-acting T-cell-specific transcription factor GATA-3
- Transcription factor 7-like 2
- Sulfhydryl oxidase 1
- Transcription factor 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0051094 (positive regulation of developmental process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0045597 (positive regulation of cell differentiation), GO:0002695 (negative regulation of leukocyte activation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:2000026 (regulation of multicellular organismal development), GO:0050866 (negative regulation of cell activation), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0045778 (positive regulation of ossification), GO:0050865 (regulation of cell activation), GO:0030278 (regulation of ossification), GO:0008284 (positive regulation of cell population proliferation), GO:0045664 (regulation of neuron differentiation), GO:0045666 (positive regulation of neuron differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0060284 (regulation of cell development), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0060251 (regulation of glial cell proliferation), GO:0010628 (positive regulation of gene expression), GO:0045669 (positive regulation of osteoblast differentiation), GO:0051960 (regulation of nervous system development), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0050768 (negative regulation of neurogenesis), GO:0007399 (nervous system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0070664 (negative regulation of leukocyte proliferation), GO:0072091 (regulation of stem cell proliferation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0060253 (negative regulation of glial cell proliferation), GO:2000648 (positive regulation of stem cell proliferation), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0045667 (regulation of osteoblast differentiation), GO:0010721 (negative regulation of cell development), GO:0051253 (negative regulation of RNA metabolic process), GO:0030182 (neuron differentiation), GO:0010629 (negative regulation of gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051249 (regulation of lymphocyte activation), GO:0050670 (regulation of lymphocyte proliferation), GO:0014014 (negative regulation of gliogenesis), GO:0032944 (regulation of mononuclear cell proliferation), GO:0050767 (regulation of neurogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0014013 (regulation of gliogenesis), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)