Protein: Serine/threonine-protein kinase TBK1 (Q0GKD6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MQSTANYLWMMSDLLGQGATANVYRGRHKKTGDLYAVKVFNNLSFLRPLDVQMREFEVLKKLNHKNIVKLFAVEEESNTRHKVLVMEYCPCGSLYTVLEEPTNAYGLPEDEFLIVLQDVVAGMNHLREYGIVHRDIKPGNIMRVIGDDGFSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITEKPPGAISGHQKFENGKIEWSSEMPISCSLSKGLQSLLTPVLANILEADQEKCWGFDQFFAETSDILHRIVVYVFSLQQATLHHVYIHTYNTANLFQELLFRRTNITPSHQELLYEGRRLVLDPNRQAQTFPKTSRDNPIMLLCRDPVNTVGLLFEDPSPPKVQPRYDLDLDASYAKTFAGDVGYLWKTSDSLLLYQELVRKGVRGLNELIRDEYSETMHKKTEVFHLCSHCSQTLERSEQLCEALMQGNILSAEYDEIRDTRKKVLRLSGSLASMDQTLQDINSMFLPGGSLTDTWTQQVGTHPEDRNVEKIKVLLDAIGAIYQQFKKDKAERRLPYNEEQIHKFDKQKLVLHATKARALFTDECAMKYRLFISKSEEWMKKFHHVRKHLLSLTGQFSSLEQEVTLLMQRLYKLLEQFPQKVVPMASGVLKPQAYLSPSTLVEMTLGMKKLKEEMEGVVKELAENNLFLERFGSLTVDGGMRTVERM
InterPro domains: - IPR051180: Inhibitor of nuclear factor kappa-B kinase (family) [1-714]
- IPR041309: TANK-binding kinase 1, coiled-coil domain 1 (domain) [400-654]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [9-307]
- IPR017441: Protein kinase, ATP binding site (binding_site) [15-38]
- IPR000719: Protein kinase domain (domain) [9-310]
- IPR041087: TANK binding kinase 1, ubiquitin-like domain (domain) [308-395]
Interaction partners: - Interferon regulatory factor 3
- TNF receptor-associated factor
- Stimulator of interferon genes protein
- Protein ref(2)P
- Guanine nucleotide exchange protein smcr8b
- Mitochondrial antiviral-signaling protein
- TNF receptor-associated factor 6
- Optineurin
- RNA helicase
- Interferon regulatory factor 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0007379 (segment specification), GO:0009966 (regulation of signal transduction), GO:0009790 (embryo development), GO:0009880 (embryonic pattern specification), GO:0035282 (segmentation), GO:0055113 (epiboly involved in gastrulation with mouth forming second), GO:0007399 (nervous system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0007369 (gastrulation), GO:0007249 (I-kappaB kinase/NF-kappaB signaling), GO:0007417 (central nervous system development), GO:0002009 (morphogenesis of an epithelium), GO:1902532 (negative regulation of intracellular signal transduction), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:1902531 (regulation of intracellular signal transduction), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0042981 (regulation of apoptotic process), GO:0002011 (morphogenesis of an epithelial sheet), GO:0001702 (gastrulation with mouth forming second), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043066 (negative regulation of apoptotic process), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)