Protein: GRB2-related adaptor protein 2 (O89100)
Organism: Mus musculus (Mouse)
Function: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc
Subcellular location: Nucleus. Cytoplasm. Endosome
Sequence: MEATAKFDFMASGEDELSFRTGDILKILSNQEEWLKAELGSQEGYVPKNFIDIEFPEWFHEGLSRHQAENLLMGKDIGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDTKGNYFLWTEKFPSLNKLVDYYRTTSISKQKQVFLRDGTQDQGHRGNSLDRRSQGGPHPSGTVGEEIRPSVNRKLSDHLPLGPQQFHPHQQPSPQFTPGPQPPQQQRYLQHFHQDRRGGSLDINDGHCGLGSEVNATLMHRRHTDPVQLQAAGRVRWARALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMMR
InterPro domains: - IPR043539: Grb2-like (family) [1-321]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [3-319]
- IPR001452: SH3 domain (domain) [1-322]
- IPR035646: GRAP2, C-terminal SH3 domain (domain) [267-319]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [49-155]
- IPR000980: SH2 domain (domain) [56-149]
Interaction partners: - Lymphocyte cytosolic protein 2
- Linker for activation of T-cells family member 1
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- Growth factor receptor-bound protein 2
- Proto-oncogene vav
- SHC-transforming protein 1
- Mitogen-activated protein kinase kinase kinase kinase 1
- Tyrosine-protein kinase ITK/TSK
- Tyrosine-protein kinase ZAP-70
- Tyrosine-protein phosphatase non-receptor type 23
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0048666 (neuron development), GO:0043408 (regulation of MAPK cascade), GO:0031175 (neuron projection development), GO:0043410 (positive regulation of MAPK cascade), GO:0048699 (generation of neurons), GO:0120036 (plasma membrane bounded cell projection organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)