Protein: Pyridoxal kinase (EC 2.7.1.35) (Pyridoxine kinase) (O00764)
Organism: Homo sapiens (Human)
Function: Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:9099727}.
Sequence: MEEECRVLSIQSHVIRGYVGNRAATFPLQVLGFEIDAVNSVQFSNHTGYAHWKGQVLNSDELQELYEGLRLNNMNKYDYVLTGYTRDKSFLAMVVDIVQELKQQNPRLVYVCDPVLGDKWDGEGSMYVPEDLLPVYKEKVVPLADIITPNQFEAELLSGRKIHSQEEALRVMDMLHSMGPDTVVITSSDLPSPQGSNYLIVLGSQRRRNPAGSVVMERIRMDIRKVDAVFVGTGDLFAAMLLAWTHKHPNNLKVACEKTVSTLHHVLQRTIQCAKAQAGEGVRPSPMQLELRMVQSKRDIEDPEIVVQATVL
InterPro domains: - IPR013749: Pyridoxamine kinase/Phosphomethylpyrimidine kinase (domain) [94-275]
- IPR029056: Ribokinase-like (homologous_superfamily) [1-312]
- IPR004625: Pyridoxine kinase (family) [2-306]
Interaction partners: - Pyridoxine-5'-phosphate oxidase
- Chronophin
- Aldehyde oxidase
- Pyridoxal phosphate phosphatase PHOSPHO2
- Pyridoxal phosphate homeostasis protein
- Thyrotroph embryonic factor
- Adrenodoxin, mitochondrial
- Ferredoxin-2, mitochondrial
- EKC/KEOPS complex subunit TP53RK
- Proliferating cell nuclear antigen
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0009636 (response to toxic substance), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006766 (vitamin metabolic process), GO:0010033 (response to organic substance), GO:0006081 (cellular aldehyde metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0010941 (regulation of cell death), GO:1901362 (organic cyclic compound biosynthetic process), GO:1901654 (response to ketone), GO:0009110 (vitamin biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0019438 (aromatic compound biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0042822 (pyridoxal phosphate metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0046184 (aldehyde biosynthetic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0033993 (response to lipid), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0014075 (response to amine), GO:0042364 (water-soluble vitamin biosynthetic process), GO:0042816 (vitamin B6 metabolic process), GO:0042823 (pyridoxal phosphate biosynthetic process), GO:0072525 (pyridine-containing compound biosynthetic process), GO:0042819 (vitamin B6 biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)