Protein: Heat shock protein 60, mitochondrial (60 kDa chaperonin) (Protein Cpn60) (O74261)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity).
Subcellular location: Mitochondrion.
Sequence: MLRVNSKSSIKTFVRHLSHKELKFGVEGRAALLKGVNTLADAVSVTLGPKGRNVLIEQQFGAPKITKDGVTVAKAITLEDKFEDLGAKLLQEVASKTNESAGDGTTSATVLGRSIFTESVKNVAAGCNPMDLRRGSQAAVEAVIEFLQKNKKEITTSEEIAQVATISANGDKHIGDLLANAMEKVGKEGVITVKEGKTLEDELEVTEGMKFDRGFISPYFITNTKTGKVEFENPLILLSEKKISSIQDILPSLELSNQTRRPLLIIAEDVDGEALAACILNKLRGQVQVCAVKAPGFGDNRKNTLGDIAILSGGTVFTEELDIKPENATIEQLGSAGAVTITKEDTVLLNGEGSKDNLEARCEQIRSVIADVHTTEYEKEKLQERLAKLSGGVAVIKVGGASEVEVGEKKDRYEDALNATRAAVEEGILPGGGTALIKATKILDEVKEKAVNFDQKLGVDTIRAAITKPAKRIIENAGEEGAVIVGKIYDEPEFNKGYDSQKGEFTDMIAAGIIDPFKVVKNGLVDASGVASLLATTECAIVDAPQPKGSPAAPPAPGMGGMPGMF
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [153-427]
- IPR018370: Chaperonin Cpn60, conserved site (conserved_site) [422-433]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [200-393]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [39-543]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [22-542]
- IPR001844: Chaperonin Cpn60/GroEL (family) [18-565]
Interaction partners: - 10 kDa heat shock protein
- Heat shock protein SSC1, mitochondrial
- Hsp70 family ATPase
- GrpE protein homolog
- Cofilin
- Heat shock protein 78
- Heat shock protein HSP70
- T-complex protein 1 subunit alpha
- Endoplasmic reticulum chaperone BIP
- Heat shock protein homolog SSE1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0035821 (modulation of process of another organism), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009408 (response to heat), GO:0051701 (biological process involved in interaction with host), GO:0009266 (response to temperature stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0033554 (cellular response to stress), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0009636 (response to toxic substance), GO:0075136 (response to host), GO:0031349 (positive regulation of defense response), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0010286 (heat acclimation), GO:0034605 (cellular response to heat), GO:1900445 (positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0044416 (induction by symbiont of host defense response), GO:0044409 (entry into host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0062039 (biofilm matrix), GO:0009277 (fungal-type cell wall), GO:0062040 (fungal biofilm matrix), GO:0030446 (hyphal cell wall)