Protein: FK506-binding protein 1 (FKBP) (12-kDa cytosolic FK506-binding protein) (FKBP-12) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (EC 5.2.1.8) (Rapamycin-binding protein) (P20081)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular location: Cytoplasm. Mitochondrion {ECO:0000269|PubMed:16823961}.
Sequence: MSEVIEGNVKIDRISPGDGATFPKTGDLVTIHYTGTLENGQKFDSSVDRGSPFQCNIGVGQVIKGWDVGIPKLSVGEKARLTIPGPYAYGPRGFPGLIPPNSTLVFDVELLKVN
InterPro domains: - IPR001179: FKBP-type peptidyl-prolyl cis-trans isomerase domain (domain) [20-114]
- IPR046357: Peptidyl-prolyl cis-trans isomerase domain superfamily (homologous_superfamily) [2-114]
- IPR050689: FKBP-type Peptidyl-prolyl cis-trans Isomerase (family) [7-113]
Interaction partners: - Serine/threonine-protein kinase TOR2
- Serine/threonine-protein kinase TOR1
- Peptidyl-prolyl cis-trans isomerase
- Calcineurin subunit B
- Target of rapamycin complex 1 subunit KOG1
- Peptidyl-prolyl cis-trans isomerase C, mitochondrial
- FKBP12-associated protein 1
- Peptidyl-prolyl cis-trans isomerase B
- Peptidyl-prolyl cis-trans isomerase CPR6
- Serine/threonine-protein phosphatase 2B catalytic subunit A1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0006457 (protein folding), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0009408 (response to heat), GO:0009991 (response to extracellular stimulus), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0007584 (response to nutrient), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0019538 (protein metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0043170 (macromolecule metabolic process), GO:0071456 (cellular response to hypoxia), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0071453 (cellular response to oxygen levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0031670 (cellular response to nutrient), GO:0031669 (cellular response to nutrient levels), GO:0036294 (cellular response to decreased oxygen levels), GO:0006995 (cellular response to nitrogen starvation), GO:0036294 (cellular response to decreased oxygen levels), GO:0043562 (cellular response to nitrogen levels), GO:0070647 (protein modification by small protein conjugation or removal), GO:0018193 (peptidyl-amino acid modification), GO:0018205 (peptidyl-lysine modification), GO:0032446 (protein modification by small protein conjugation), GO:0016925 (protein sumoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)