wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Proteasome subunit alpha type (B5XG08)
Organism: Salmo salar (Atlantic salmon)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.
Sequence: MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSLAIRGQDCAVVVTQKKVPDKLLDASTVTHLFKITENIGCVMSGMAADSKSQVQRARYEAANWKYKYGYEIPVDMLCKRMADVSQVYTQNAEMRPLGCCMIVIGVDEECGPQVYKCDPAGYYCGFKATAAGVKQTEATTFLEKKVKKKLDWTFAQTIETAITCLSTVLSIDFKPSELEIGVITTEDPKFRILTETEIDVHLVSLSERD
InterPro domains: - IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [1-246]
- IPR034642: Proteasome subunit alpha6 (family) [8-220]
- IPR001353: Proteasome, subunit alpha/beta (family) [35-220]
- IPR050115: Proteasome subunit alpha (family) [13-238]
- IPR000426: Proteasome alpha-subunit, N-terminal domain (domain) [9-31]
- IPR023332: Proteasome alpha-type subunit (family) [24-239]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0019899 (enzyme binding), GO:0035375 (zymogen binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0097677 (STAT family protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0034097 (response to cytokine), GO:0034341 (response to type II interferon), GO:0071310 (cellular response to organic substance), GO:0071346 (cellular response to type II interferon), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Microfibrillar-associated protein 5 (MFAP-5) (MP25) (Microfibril-associated glycoprotein 2) (MAGP-2) (Q28022)
Organism: Bos taurus (Bovine)
Function: May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Sequence: MTFFGPKVLLLLTALIMSSGRTPLGVSGQRGDDVTTVTSETFTEDPNLVNDPATDETVLADIQPSTDDLASLNDKNTTTECRDEKFACTRLYSVHRPIKQCLHQICFTSSRRMYVINNEICSRLVCKEHEAMKDELCRQKAGLPPRRLRRSNYFRLPPCDNVNLQGPSGL
InterPro domains: - IPR008673: Microfibril-associated glycoprotein (family) [3-160]
Interaction partners: - Fibrillin-1
- Microfibrillar-associated protein 2
- Elastin
- Fibulin-5
- Lysyl oxidase homolog 1
- Fibrillin-2
- Multiple EGF like domains 6
- Microfibril-associated glycoprotein 3
- Microfibril-associated glycoprotein 4
- Myocilin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005201 (extracellular matrix structural constituent)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009893 (positive regulation of metabolic process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:0045597 (positive regulation of cell differentiation), GO:0045595 (regulation of cell differentiation), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030858 (positive regulation of epithelial cell differentiation), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0043588 (skin development), GO:0060429 (epithelium development), GO:0008544 (epidermis development), GO:0030855 (epithelial cell differentiation), GO:0009913 (epidermal cell differentiation), GO:0030216 (keratinocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0099080 (supramolecular complex), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0099081 (supramolecular polymer), GO:0031012 (extracellular matrix), GO:0001527 (microfibril), GO:0099512 (supramolecular fiber), GO:0062023 (collagen-containing extracellular matrix)
Protein: E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb protein X 1) (Ligand of Numb-binding protein 1) (Numb-binding protein 1) (RING-type E3 ubiquitin transferase LNX) (O70263)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
Subcellular location: Cytoplasm.
Sequence: MNQPDLADDPDPSPEPLCIVCGQNHSPEENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPVDRKPVVLQHCKKSSILVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDGEPVANSSDSGRSNRTRARPFERSTMRSRSFKKINRALSALRRTKSGSVVANHVDQGRDNSENTTVPEVFPRLFHLIPDGEITSIKINRADPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLRLTVLREQKFRSRSNAHVPDSYGPRDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQSSPDIFQEAGWISNGQQSPGPGERNTASKPAATCHEKVVSVWKDPSESLGMTVGGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVNGIELTEVSRTEAVAILKSAPSSVVLKALEVKEQEAQEDCSPAALDSNHNVTPPGDWSPSWVMWLELPQYLCNCKDVILRRNTAGSLGFCIVGGYEEYSGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARMLKELKGRITLTIASWPGTFL
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [269-725]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [60-69]
- IPR051342: PDZ domain-containing scaffold protein (family) [30-720]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [15-142]
- IPR001478: PDZ domain (domain) [278-724]
- IPR001841: Zinc finger, RING-type (domain) [45-83]
Interaction partners: - Protein numb homolog
- Numb-like protein
- Melanoma-associated antigen B18
- Coxsackievirus and adenovirus receptor homolog
- Ubiquitin-conjugating enzyme E2 N
- Ubiquitin-ribosomal protein eS31 fusion protein
- Immunoglobulin superfamily member 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0008283 (cell population proliferation), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0061351 (neural precursor cell proliferation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Uncharacterized membrane protein C1322.03 (O94543)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000269|PubMed:16823372}.
Sequence: MKPRPYSVFLFLHIVFYSLLSAVNGSPSLDYFETCSNFVPRAGIPTFSPYAVIKNFDEVNRMYYIQVVGNLSGVITIVGGNGSHIHAASVYSETYALGKLVTSNTTKLCDVVMDPHSFEVPIKCPWAAGSAAFMVKVPFKSTLSDYSKYELTTLTTRVIVVDGTPEKNVITCMKFGLSTTLYYFYPVISYLVVVSLAYVSFSIIYALFLNPWTGSLDPFKSIFNFNMDPDALRLTSLGFFDFVQYLQFAVSTAQVSVMFPKFYINIMAALSWGTALFRFPIFSEPAEYQFADFADLSVASSSYADYLPKSYGMYSFLDSIGIGTACWLPFLIVMVIYLFAALFVALLVIFLKWLMSRIFNETIAETRWDTWSFIAGSLIRLYFLTYFPTVAYMSFQFVAPPTGYEIIPVLWFIFFGIFIPVYLYMNLAFVEPSSKLLEDQTYLHLFGSIYNSFREERVMFWIFPIAVQFMRGITVGVIGSSGSAQLAIFFILEVANVVAYAYVRPHFPQTSMNTLNTFISTMRLITVILMIPLDPRLKVLGISRDLLAYAILFIHIMVCILFLLLSTQRFMEVSARLLGAKSESKGVPLDRPFGWARVFGINELRRRRLKDPYSNGNTMMFDHSTYNSNEMSVPLTPVSVCSNSLKKDGEAAPPKLFVQTNCIPPVTQASSLVPSKNNTASSSSLMLDSPVTPSSPYSTSQGYSFYRPPKPKSSVRKRDMDQLRALQLDFLNNKPNLLRHDVNYAVREADVYHPHVDTSIDSLSQISSQPFEMRPTAIPPPPKNAFQRAWQIVQSTAKSIWHSDPPKESEKGFVVLRSRPRPNLQKPLPQLHIEPSRDEQYSMERKKTDDSLAESAWSIPHP
InterPro domains: - IPR032800: ML-like domain (domain) [25-184]
- IPR040241: Transient receptor potential channel Flc/Pkd2-like (family) [8-819]
- IPR010308: TRP, C-terminal (domain) [321-565]
Interaction partners: - Uncharacterized membrane protein C663.14c
- TRP-like ion channel pkd2
- Stretch-activated cation channel yam8
- Vacuolar calcium ion transporter
- Uncharacterized serine-rich protein C1E8.05
- Calcium-channel protein cch1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ASTRA-associated protein 1 (Q06822)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ASTRA complex involved in chromatin remodeling.
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MRGFSNEIILKRTLTLSDFTLRYHKRGITALQVIKAPSVSNVPVLLSGDNYGYFVMWDLVTKRPITHIEIEGNSHIIAFWWVETTNVLYILSKDSMLRIFELDSSTQLSIDLVRKLSQANKTDHLQWTKIYEMPINTLNFANFIIEAEVKPTKDNKSYRLVCCHTDDSETIDIYQIIEDSTFKLKRPFNNINFPRFLKQQNFLGISKDSKFGIIMRFAKLNDVIFLGYENGFVVGFKITFDEGLQRDIAELVHVSNDHYPNPILDMCVSGDELYSCSTDDFITKYKIPVNLQLETKYLRDDALLIKCPSSLRVSEPSKVHLPLKNIGHIDKVKDDYLVVSSWSGMTIVYNMRTSEVEQTFVKSKNNLVVSDSSMGDLTNGSGSNTESSSKSHNYKVGAMTCLESFDVQSDGLRLGQLRRIKALAKCNWCLIGYEDGTIKLNKI
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [8-211]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [19-360]
Interaction partners: - TEL2-interacting protein 1
- RuvB-like protein 1
- RuvB-like protein 2
- Telomere length regulation protein TEL2
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- TEL2-interacting protein 2
- Protein interacting with Hsp90 1
- SAGA complex/transcription factor TFIID complex subunit TAF9
- SAGA complex/transcription factor TFIID complex subunit TAF12
- TATA-box-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0051640 (organelle localization), GO:0050794 (regulation of cellular process), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0051656 (establishment of organelle localization), GO:0051647 (nucleus localization), GO:0007097 (nuclear migration), GO:0010970 (transport along microtubule), GO:0006996 (organelle organization), GO:0099111 (microtubule-based transport), GO:0072384 (organelle transport along microtubule), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0007010 (cytoskeleton organization), GO:0030473 (nuclear migration along microtubule), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein MAK10 homolog (O17003)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MPGAMESPNESEDVSKTFFKLCDGLRLGELVTTEHFRLSDVMSAIELGEPKMDVGVGSKHIKTLKEAISGGLYADDYPFQLAIMDSTLAMVVAWLEGSALGSTVWTNVLLSNVTFVKHPVFHPFASGVNLFIRNAHALINSVGNLEELPEDFNPQMLFSHQRWAPRRVVVQLMREQVTLLGTTGRKWRESAFSKQAYDICCAVASRLEMFIMLLEIIGLLVAPEIEDPNFDHKVHLGDFYVHEKEYEGAEENSDEKSEESTSDPTPSSEAKSETTEKKEQKSNDEATDETDQNDDENVGDDEDEDDMKQFKPNFGFASILAERLCKVTKAYAETVKLGRRAPDNIDGDGDYLWLGAYEPKTCIRMIPACFPRKIKVPSRQEAADWWVKCAERIYHLCIVTPKTSKDLNYLFYFARTFGQNACVFTRSLLQICMFPVDNHLCGDENRSIADAVEYSLSNCFCPQILDRVSPVYKDQTAQSLYVLFLNHMSKLAITVYGSFGCNLSRQRDRLEMAIEDLGQIHSYAGRLEERTDEVLLSGKMVTAKEQNYSYHSVATFVFHNLLAIINHYFELGFRMDLYVPYEFPYIYWFIGSVQAHWMRTTLERSQEIQLNVYQANPLRETKNKKLWEERCKLGEELKRRVAAHQFSVLNQIAISMISDGVVRLTVVLIRKGIIKMPKGGDDAEKLRFERRFEPFDSLGPPVRVDYERFKSDSGIDQMYEDKIETLIDQAQKSFNEAREHLEKIDNSVEQNREMMQLIHVAKSNIIACRVLKLDLTDRNVVWSFSEEIPMFPCLKISKK
InterPro domains: - IPR007244: NAA35-like (family) [3-798]
- IPR057982: NAA35-like, TPR repeats (domain) [407-792]
- IPR057983: NAA35-like, N-terminal (domain) [28-112]
Interaction partners: - N-terminal methionine N
- N-alpha-acetyltransferase daf-31
- Sm domain-containing protein
- N-alpha-acetyltransferase 16, NatA auxiliary subunit
- Probable small nuclear ribonucleoprotein-associated protein B
- Histidine ammonia-lyase
- Zinc transporter ttm-1
- PID domain-containing protein
- Probable small nuclear ribonucleoprotein E
- N-terminal acetyltransferase B complex subunit NAA25 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0008340 (determination of adult lifespan)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Putrescine hydroxycinnamoyltransferase 2 (OsPHT2) (EC 2.3.1.-) (Q5SMQ0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Hydroxycinnamoyl transferase that catalyzes the transfer of an acyl from p-coumaryol-CoA to putrescine, to produce coumaroyl putrescine.
Sequence: MATVEVLTSEVVAPAEETPAGAVWLSNLDLAARRGYTPTVYFYRRNGDDEAAFFAADAVRDGLARALVPFYPLAGRLGLAGGGEDGRVQIDCTGEGAVFVTARSGHYALDDLMNEFVPCDEMRDLFVPPTPPPNPPCALLLVQVTHLRCGGVVLGMALHHSVVDARSAAHFAETWASIVRGAPAGDAPVPPCFDHKLLAARPARAVLYDHPEYKPEPAPAPAHAATASTYASAIITLTKQQVGALKAACAGASTFRAVVALVWQCACRARSLPPDKANLFLLYKYISEDWVDIQLNIQQRDNCIYAPTLKANCCFTPTF
InterPro domains: - IPR050317: Plant and Fungal Acyltransferase (family) [9-275]
- IPR023213: Chloramphenicol acetyltransferase-like domain superfamily (homologous_superfamily) [2-284]
Interaction partners: - 4-coumarate--CoA ligase 2
- 4-coumarate--CoA ligase-like 9
- Hydrolase, alpha/beta fold family protein, putative, expressed
- Nitrate reductase
- Nitrate reductase
- Nitrate reductase 1
- Os12g0262700 protein
- Os01g0315700 protein
- Probable 5'-adenylylsulfate reductase 1, chloroplastic
- Os01g0820000 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009698 (phenylpropanoid metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009699 (phenylpropanoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Major capsid protein 1 (MCP1) (Major capsid protein VP1) (A0A6M3VZT9)
Organism: Pyrobaculum filamentous virus 2 (PFV2)
Function: Self-assembles to form a helical, filamentous nucleocapsid mesuring 400 nm in length and 20 nm in width (Probable). Together with capsid protein 2, wraps arounds the DNA and maintains it in an A-form (Probable). Capsid proteins probably maintain the DNA in A-form by non-specific desolvation and specific coordination of the DNA phosphate groups by positively charged residues (Probable). This certainly protects the viral DNA under conditions such as the extreme desiccation of its host (Probable).
Subcellular location: Virion {ECO:0000269|PubMed:32368353}.
Sequence: MSVVTTRARIAETLTEKHTLGIEKVVATDSWRVGITSREKKLERINISAEISRRIQDEAIAYARNKGIPYLPGINGIAWKLLRLKWLGYTDQINVVMRTVPAEWRDFLTQIMENTQMESMYSELRKVRV
InterPro domains: - IPR057994: Major capsid protein 1, PFV (family) [1-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0039693 (viral DNA genome replication), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0033643 (host cell part), GO:0043229 (intracellular organelle), GO:0043657 (host cell), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0020003 (symbiont-containing vacuole), GO:0033655 (host cell cytoplasm part), GO:0030430 (host cell cytoplasm)