Protein: Dystroglycan 1 (Dystroglycan) (Dystrophin-associated glycoprotein 1) [Cleaved into: Alpha-dystroglycan (Alpha-DG); Beta-dystroglycan (Beta-DG)] (O18738)
Organism: Bos taurus (Bovine)
Function: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
Subcellular location: [Alpha-dystroglycan]: Secreted, extracellular space {ECO:0000250}.; SUBCELLULAR LOCATION: [Beta-dystroglycan]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). Colocalizes with ERM proteins in Schwann-cell microvilli (By similarity). In peripheral nerves, localizes to the Schwann cell membrane. {ECO:0000250}.
Sequence: MRMSVGSAVPLPLWGRTFLLLLSVAVTQSHWPSEPSEAVRDWENQLEASMHSALSDLHETVPTVVGIPDGTAVVGRSFRVTIPTDLIASNGEVIKVSAAGKEALPSWLHWDPQSHTLEGLPLDTDKGVHYISVSAARLGANGSHVPQTSSVFSIEVYPEDHSEPQSLRAASPDPGEVVSLVCAADEPVTVLTVILDADLTKMTPKQRIDLLRRMRGFSEVEPHNMKLVPVVNNRLFDMSAFMAGPGNAKKVVENGALLSWKLGCCLNQNSVPDIRGVEVPAREGAMSAQLGYPVVGWHIANKKPSLPKRIRRQIHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTETMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVSEAGTTVPSQIRPTMTIPGYMEPSTVTTPPTTTTKKPRVSTPRPATPSTDSSTTTTRRPTKKPRTSRPVPRVTTKAPITRLETASPATRMRTTTSGVPHGGEPNQRPELKNHIDRVDAWVGTYFEVKIPSDTFYDNEDTTTDKLKLTLKLREQQLVGEKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLSAVDAFEIHVHRRPQGDKAPARFKAKLTGDPAAVTNDIHKKIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTLPLEPCPKEQITALSRRIAEDDGKPRGAFVNALEPDFQAMSITVTGSGSCRHLQFVPVAPPMRVPSEAPATEVPDRDPEKSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKGKLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQEEKAPLPPPEYPNQSMPETTPLNQDTVGEYAPLRDEDPSAPPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP
InterPro domains: - IPR030398: DG-type SEA domain (domain) [603-712]
- IPR008465: Dystroglycan, C-terminal (domain) [607-895]
- IPR027468: Alpha-dystroglycan domain 2 (homologous_superfamily) [181-315]
- IPR041631: Alpha-dystroglycan N-terminal domain 2 (domain) [181-304]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [52-599]
- IPR006644: Dystroglycan-type cadherin-like (domain) [62-602]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [62-597]
Interaction partners: - Agrin
- Dystrophin
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
- Neurexin-3-beta
- Pikachurin
- Neurexin 2.
- Neurexin-1
- Uncharacterized protein.
- Dolichyl-phosphate-mannose--protein mannosyltransferase
- Dolichyl-phosphate-mannose--protein mannosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0043395 (heparan sulfate proteoglycan binding), GO:0043394 (proteoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0006807 (nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0051668 (localization within membrane), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0072657 (protein localization to membrane), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0008104 (protein localization), GO:0042157 (lipoprotein metabolic process), GO:0042158 (lipoprotein biosynthetic process), GO:0006497 (protein lipidation), GO:1990778 (protein localization to cell periphery), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:0018198 (peptidyl-cysteine modification), GO:0018345 (protein palmitoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)