Protein: Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331) (Q04589)
Organism: Rattus norvegicus (Rat)
Function: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15117958}; Single-pass type I membrane protein {ECO:0000269|PubMed:15117958}. Nucleus {ECO:0000269|PubMed:15117958}. Cytoplasm, cytosol {ECO:0000269|PubMed:15117958}. Cytoplasmic vesicle {ECO:0000250}. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity). {ECO:0000250}.
Sequence: MWGWRGLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACVTNSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYDQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQDSPSFPDTRSSTCSSGEDSVFSHEPFPEEPCLPRHPTQLANGGLNRR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [468-754]
- IPR016248: Fibroblast growth factor receptor family (family) [6-820]
- IPR050122: Receptor Tyrosine Kinase (family) [82-762]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [39-358]
- IPR000719: Protein kinase domain (domain) [478-767]
- IPR013098: Immunoglobulin I-set (domain) [168-358]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [25-365]
- IPR007110: Immunoglobulin-like domain (domain) [25-357]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [42-113]
- IPR003598: Immunoglobulin subtype 2 (domain) [46-348]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [479-754]
- IPR017441: Protein kinase, ATP binding site (binding_site) [484-514]
- IPR003599: Immunoglobulin domain subtype (domain) [40-359]
- IPR028174: Fibroblast growth factor receptor 1, catalytic domain (domain) [464-765]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [619-631]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [478-754]
Interaction partners: - Klotho
- Fibroblast growth factor 2
- Fibroblast growth factor 1
- Fibroblast growth factor 23
- Fibroblast growth factor 9
- Fibroblast growth factor 16
- Klotho beta
- Fibroblast growth factor 10
- Fibroblast growth factor 7
- Fibroblast growth factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004888 (transmembrane signaling receptor activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019838 (growth factor binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0017134 (fibroblast growth factor binding), GO:0004714 (transmembrane receptor protein tyrosine kinase activity), GO:0005007 (fibroblast growth factor receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035265 (organ growth), GO:0042221 (response to chemical), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0048729 (tissue morphogenesis), GO:0043207 (response to external biotic stimulus), GO:0009611 (response to wounding), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0098868 (bone growth), GO:0001704 (formation of primary germ layer), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0008284 (positive regulation of cell population proliferation), GO:0003416 (endochondral bone growth), GO:0048333 (mesodermal cell differentiation), GO:0071559 (response to transforming growth factor beta), GO:0097305 (response to alcohol), GO:0032496 (response to lipopolysaccharide), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071310 (cellular response to organic substance), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:0071774 (response to fibroblast growth factor), GO:0002237 (response to molecule of bacterial origin), GO:0060485 (mesenchyme development), GO:0050678 (regulation of epithelial cell proliferation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0042060 (wound healing), GO:0060348 (bone development), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0001501 (skeletal system development), GO:0033993 (response to lipid), GO:0048332 (mesoderm morphogenesis), GO:0007498 (mesoderm development), GO:0048762 (mesenchymal cell differentiation), GO:1901701 (cellular response to oxygen-containing compound), GO:0071363 (cellular response to growth factor stimulus), GO:0032526 (response to retinoic acid), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0001837 (epithelial to mesenchymal transition), GO:0045471 (response to ethanol), GO:0071300 (cellular response to retinoic acid), GO:0071396 (cellular response to lipid), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0044344 (cellular response to fibroblast growth factor stimulus), GO:0008543 (fibroblast growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)