wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cuscuta receptor 1 (A0A3Q7HJG4)
Organism: Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Function: Involved in plant defense. Contributes to resistance against parasitic plant C.reflexa. Acts as a receptor for the 11 kDa glycine-rich protein (GRP) of C.reflexa inducing immune responses such as emission of stress-related phytohormone ethylene, reactive oxygen species (ROS) release, and hypersensitive cell death. Recognizes a specific pathogen-associated molecular pattern (PAMP), a cysteine-rich peptide 21 (crip21), from GRP located on the cell wall of C.reflexa
Subcellular location: Cell membrane; Single-pass membrane protein. Cell surface
Sequence: MGNIKFLLLVFFLIVVVVNGCWEEERNALLELQTNIMSSNGELLVDWAGYNAAHFVDCCFWDRVKCSLETGRVIKLDLEADFGTGDGWLFNASLFLPFKSLQVLLLSSQNIIGWTKNEGFSKLRQLPNLKEVDLQYNPIDPKVLLSSLCWISSLEVLKLGVDVDTSFSIPMTYNTNMMSKKCGGLSNLRELWFEGYEINDINILSALGELRNLEKLILDDNNFNSTIFSSLKIFPSLKHLNLAANEINGNVEMNDIIDLSNLEYLDLSDNNIHSFATTKGNKKMTSLRSLLLGSSYSNSSRVIRSLKSFSSLKSLSYKNSNLTSPSIIYALRNLSTVEYLYFKGSSLNDNFLPNIGQMTSLKVLNMPSGGNNGTLPNQGWCELKYIEELDFLNNNFVGTLPLCLGNLTSLRWLSLAGNNLHGNIASHSIWRRLTSLEYLDIADNQFDVPLSFSQFSDHKKLIYLNVGYNTIITDTEYQNWIPNFQLEFFAIQRCIALQKLPSFLHYQYDLRILAIEGNQLQGKFPTWLLENNTRLAAIYGRDNAFSGPLKLPSSVHLHLEAVDVSNNKLNGHIPQNMSLAFPKLLSLNMSHNHLEGPIPSKISGIYLTILDLSVNFLSGEVPGDLAVVDSPQLFYLRLSNNKLKGKIFSEEFRPHVLSFLYLNDNNFEGALPSNVFLSSLITLDASRNNFSGEIPGCTRDNRRLLQLDLSKNHLQGLIPVEICNLKIINVLAISENKISGSIPSCVSSLPLKHIHLQKNQLGGELGHVIFNFSSLITLDLRYNNFAGNIPYTIGSLSNLNYLLLSNNKLEGDIPTQICMLNNLSIVDLSFNKLYGPLPPCLGYLTQTKKDAEISWTYFAENYRGSWLNFVIWMRSKRHYHDSHGLLSDLFLMDVETQVQFSTKKNSYTYKGNILKYMSGIDLSSNRLTGEIPVELGNMSNIHALNLSHNHLNGRIPNTFSNLQEIESLDLSCNRLNGSIPVGLLELNSLAVFSVAYNNLSGAVPDFKAQFGTFNKSSYEGNPFLCGYPLDNKCGMSPKLSNTSNINGDEESSELEDIQCFYIGFVVSFGAILLGLAAALCLNRHWRRAWFRMIEALMFYCYYFVLDNIVTPIKSRWYKNVG
InterPro domains: - IPR003591: Leucine-rich repeat, typical subtype (repeat) [126-986]
- IPR051502: Receptor-like Defense Trigger (family) [379-1094]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [18-1040]
- IPR001611: Leucine-rich repeat (repeat) [211-983]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein dao-4 (Q23262)
Organism: Caenorhabditis elegans
Function: Probably acts downstream of the Wnt signaling pathway
Subcellular location: Nucleus. Secreted
Sequence: MKIALYSILLITVCYLSSTDAYLFDPKAVDALLREIRARLQATGKEPHARKIEQETEEIKKEELMQAEDVEGSGSGEEIEGSGEVISTITGVPIMDNEEKKDLKPENFPRPEPIFDKYGNLKSKDKLEALTYSNFKKQAPATLQDHYNLNPTGTLQMLQGLDIHGGSGGYHRALSGGYLPPSTYDPYNVNWHSYGDEGVKMKDKAISVFRRVIAPGR
Interaction partners: - Cuticle collagen 49
- Cuticle collagen 71
- Nematode cuticle collagen N-terminal domain-containing protein
- Cuticle collagen 38
- peptidylprolyl isomerase
- Prion-like-(Q/N-rich)-domain-bearing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0045927 (positive regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:0040008 (regulation of growth), GO:0048639 (positive regulation of developmental growth), GO:0010171 (body morphogenesis), GO:0040014 (regulation of multicellular organism growth), GO:0048638 (regulation of developmental growth), GO:0040018 (positive regulation of multicellular organism growth)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0060102 (collagen and cuticulin-based cuticle extracellular matrix)
Protein: Death-associated protein-like 1 (Q9D757)
Organism: Mus musculus (Mouse)
Function: May play a role in the early stages of epithelial differentiation or in apoptosis
Sequence: MANEVQVLPSPLKGRYAPAVKAGGMRISKKQEMGVLERHTKKTGLEKTSAITNVAKIQMLDALTDTLDKLNHKFPATVHTAHQKPTPALEKAAPMKRAYIIQQPRKC
InterPro domains: - IPR024130: DAP1/DAPL1 (family) [1-106]
Interaction partners: - Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein eS1
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL24
- Small ribosomal subunit protein eS19
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein eL30
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Diacylglycerol O-acyltransferase 3-2 (I1MRZ6)
Organism: Glycine max (Soybean) (Glycine hispida)
Function: Involved in triacylglycerol (TAG) biosynthesis. Catalyzes the acylation of the sn-3 hydroxy group of sn-1,2-diacylglycerol using acyl-CoA. Incorporates preferentially monounsaturated fatty acids (MUFAs), especially oleic acid (C18:1) and to some extent palmitoleic acid (C16:1), into TAGs accumulating in seeds oil. Can also use, with low efficiency, hexadecanoic acid (C16:0), linoleic acid (C18:2) and linolenic acid (C18:3) as acyl-CoA substrates
Subcellular location: Cytoplasm
Sequence: MEISGTVLRQVSYVSGYGTHTRSRGLAPRFGVRMGMGSGFCDEGHLRYYQDTKKVLTPKKKLKLLKGFSKLGLASDPEKLAMFYDLQQNLTSDAGDVLLRELEAARAKEKEVKKKRKQEKKAKLKAAKMNCESSSSSSSESSDSDCGCDQVVDMNTFRAGVGVGVGVGVGVVAPAPVEESPLPKTAPIVEDANAHCVAMELCSKNDIYVSSASNGFKNESAVVTSAPQKRIEVCMGNKCKRSGAAALMQEFEKVVGVEGVAVVACKCMGKCKTAPNVKVQNSVDHNSLAQGLDDSVKIPANPLCIGVGLEDVDAIVARYFWESHTDIGMAGAGAATAT
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [226-285]
Interaction partners: - Diacylglycerol O-acyltransferase 1B
- Acyltransferase
- Diacylglycerol O-acyltransferase 2D
- Acyltransferase
- Acyltransferase
- Diacylglycerol O-acyltransferase 3-1
- diacylglycerol O-acyltransferase
- Diacylglycerol O-acyltransferase 1A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016740 (transferase activity), GO:0043169 (cation binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006638 (neutral lipid metabolic process), GO:0046460 (neutral lipid biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0046463 (acylglycerol biosynthetic process), GO:0006639 (acylglycerol metabolic process), GO:0006641 (triglyceride metabolic process), GO:0019432 (triglyceride biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Cell-surface associated glycoprotein DFI1 (Q5AFI4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cell-surface associated glycoprotein that acts as a plasma membrane receptor-type protein which senses the presence of matrix. Binds to calmodulin in response to environmental conditions and initiates a signaling cascade that activates CEK1, thus promoting invasive filamentation. Involved in the maintenance of the cell wall
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell septum. Secreted, cell wall. Note=A part becomes cross-linked to the cell wall and thus links the cell wall to the plasma membrane and cytoplasm
Sequence: MEKLSINNNNNNRRYQSRRFDGITIIRIVVLVFIVTVSTYFVNSYTCNQPHHNHSTRPSHYLPINGTHGLMNNDDSLHNKGAIGHYNTTVSLERRADENNSTTNGLFPSTSSSTFIFTPSSSSSSTFQQSRSSPQTTSTSSFVATTSSFQQETSQTSIPDTTTDFSFSSFSEAPTTSTTSSTSEFSSTPQETSNTVTSTSSTSTSSSSSPTSSPATTSASQHVTTFSSVDNGKTIVVTRTSVISSSPTASNSNNNKNNDNGGGLSHTNRIVVGVVVGVGGSILIGLLAVLFYLRKRNNRDYEGGWTFWRKNEKLGSDEFFNGELGVRDRNINQGSNF
InterPro domains: - IPR007567: Mid2 domain (domain) [224-293]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Repressor protein of division inhibition gene dicB (P06965)
Organism: Escherichia coli (strain K12)
Function: This protein is a repressor of division inhibition gene dicB
Sequence: MLKTDALLYFGSKTKLAQAAGIRLASLYSWKGDLVPEGRAMRLQEASGGELQYDPKVYDEYRKTKRAGRLNNENHS
InterPro domains: - IPR010982: Lambda repressor-like, DNA-binding domain superfamily (homologous_superfamily) [1-61]
Interaction partners: - HTH-type transcriptional regulator DicA
- Division inhibition protein DicB
- Uncharacterized protein YdfA
- Uncharacterized protein YdfA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex), GO:0032993 (protein-DNA complex), GO:0017053 (transcription repressor complex), GO:0110001 (toxin-antitoxin complex)
Protein: DNA damage-inducible protein I (P0ABR1)
Organism: Escherichia coli (strain K12)
Function: Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA
Sequence: MRIEVTIAKTSPLPAGAIDALAGELSRRIQYAFPDNEGHVSVRYAAANNLSVIGATKEDKQRISEILQETWESADDWFVSE
InterPro domains: - IPR036687: DinI-like superfamily (homologous_superfamily) [1-81]
- IPR010391: DNA damage-inducible protein DinI-like (family) [1-81]
Interaction partners: - Protein RecA
- Protein RecA
- Protein RecA
- Protein RecA
- LexA repressor
- Uncharacterized protein YebG
- Uncharacterized protein YebG
- Uncharacterized protein YebG
- Protein UmuD
- Regulatory protein RecX
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0006950 (response to stress), GO:0009991 (response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus), GO:0009432 (SOS response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1905348 (endonuclease complex), GO:1905347 (endodeoxyribonuclease complex)
Protein: DnaJ homolog subfamily C member 16 (Q9Y2G8)
Organism: Homo sapiens (Human)
Function: Plays an important role in regulating the size of autophagosomes during the formation process
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
Sequence: MEVRKLSISWQFLIVLVLILQILSALDFDPYRVLGVSRTASQADIKKAYKKLAREWHPDKNKDPGAEDKFIQISKAYEILSNEEKRSNYDQYGDAGENQGYQKQQQQREYRFRHFHENFYFDESFFHFPFNSERRDSIDEKYLLHFSHYVNEVVPDSFKKPYLIKITSDWCFSCIHIEPVWKEVIQELEELGVGIGVVHAGYERRLAHHLGAHSTPSILGIINGKISFFHNAVVRENLRQFVESLLPGNLVEKVTNKNYVRFLSGWQQENKPHVLLFDQTPIVPLLYKLTAFAYKDYLSFGYVYVGLRGTEEMTRRYNINIYAPTLLVFKEHINRPADVIQARGMKKQIIDDFITRNKYLLAARLTSQKLFHELCPVKRSHRQRKYCVVLLTAETTKLSKPFEAFLSFALANTQDTVRFVHVYSNRQQEFADTLLPDSEAFQGKSAVSILERRNTAGRVVYKTLEDPWIGSESDKFILLGYLDQLRKDPALLSSEAVLPDLTDELAPVFLLRWFYSASDYISDCWDSIFHNNWREMMPLLSLIFSALFILFGTVIVQAFSDSNDERESSPPEKEEAQEKTGKTEPSFTKENSSKIPKKGFVEVTELTDVTYTSNLVRLRPGHMNVVLILSNSTKTSLLQKFALEVYTFTGSSCLHFSFLSLDKHREWLEYLLEFAQDAAPIPNQYDKHFMERDYTGYVLALNGHKKYFCLFKPQKTVEEEEAIGSCSDVDSSLYLGESRGKPSCGLGSRPIKGKLSKLSLWMERLLEGSLQRFYIPSWPELD
InterPro domains: - IPR013766: Thioredoxin domain (domain) [119-247]
- IPR043361: DnaJ homolog subfamily C member 16, TRX domain (domain) [136-245]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [146-247]
- IPR018253: DnaJ domain, conserved site (conserved_site) [70-89]
- IPR052448: DnaJ Homolog Subfamily C Member 16 (family) [1-741]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [27-137]
- IPR001623: DnaJ domain (domain) [28-104]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0051056 (regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: DnaJ homolog subfamily C member 18 (Q9H819)
Organism: Homo sapiens (Human)
Function: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection. Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane. The foci represent the site from which SV40 penetrates into the cytosol
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Sequence: MAATLGSGERWTEAYIDAVRRNKYPEDTPPESHDPCGCCNCMKAQKEKKSENEWTQTRQGEGNSTYSEEQLLGVQRIKKCRNYYEILGVSRDASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRARPYNYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTYYYRRRHRHERTQTQKEEEEEKPQTTYSAFIQLLPVLVIVIISVITQLLATNPPYSLFYKSTLGYTISRETQNLQVPYFVDKNFDKAYRGASLHDLEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLIGLRRGG
InterPro domains: - IPR051100: DnaJ subfamily B/C chaperone co-factors (family) [45-350]
- IPR018253: DnaJ domain, conserved site (conserved_site) [123-142]
- IPR015399: Domain of unknown function DUF1977, DnaJ-like (domain) [250-348]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [77-191]
- IPR001623: DnaJ domain (domain) [81-157]
Interaction partners: - Heat shock protein 105 kDa
- Heat shock cognate 71 kDa protein
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
- Heat shock-related 70 kDa protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0031072 (heat shock protein binding), GO:0030544 (Hsp70 protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0071840 (cellular component organization or biogenesis), GO:0006458 ('de novo' protein folding), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0061077 (chaperone-mediated protein folding), GO:0051084 ('de novo' post-translational protein folding), GO:0051085 (chaperone cofactor-dependent protein refolding), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Deoxyhypusine hydroxylase (Q59Z14)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor
Subcellular location: Cytoplasm. Nucleus
Sequence: MSADEVNIDTASLEELRDILINKTGNTKLANRFRALFNLKSVGSEDSDKERAHKAIKYIAECFNDDSELLKHEVAYVLGQTKDLYAAPYLREVLENDNQQCMVRHEAAEALGALGDKESLPLLEKYFKEDPLLEIRQTCELAIERIHWENSEKAKNEVLEKSLYTSIDPAPPLATNDSTSKVEKLKEILNDQDKPLFERYRAMFRLRDIGTDEACLALASGFDDPSALFKHEIAYVFGQMCNPVTVPSLIKVLKDESEAGMVRHEAAEALGSIATDECLPVLQSFLNDSEPVVRDSAIVALDMYEYENSNELEYATVK
InterPro domains: - IPR004155: PBS lyase HEAT-like repeat (repeat) [68-289]
- IPR016024: Armadillo-type fold (homologous_superfamily) [68-302]
- IPR011989: Armadillo-like helical (homologous_superfamily) [9-313]
- IPR021133: HEAT, type 2 (repeat) [245-285]
- IPR027517: Deoxyhypusine hydroxylase (family) [13-313]
Interaction partners: - Eukaryotic translation initiation factor 5A
- Deoxyhypusine synthase
- Elf1p
- Ribosome biosynthesis protein
- Elongation factor 3
- malate dehydrogenase (oxaloacetate-decarboxylating)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0030447 (filamentous growth), GO:0009628 (response to abiotic stimulus), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0009268 (response to pH), GO:0042710 (biofilm formation), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0036176 (response to neutral pH), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)