Protein: Kinesin light chain 1 (KLC 1) (O88447)
Organism: Mus musculus (Mouse)
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Subcellular location: Cell projection, growth cone {ECO:0000250|UniProtKB:P37285}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P37285}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P37285}.
Sequence: MYDNMSTMVYIKEEKLENVTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSSMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQNVRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDSDSSKEPLDDLFPNDEDEPGQGIQHSDSSAAAARQGYEIPARLRTLHNLVIQYASQGRYEVAVPSCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGRDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALGIYQTKLGPDRTPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEAEFGSVDDENKPIWMHAEEREECKGKQKDGSAFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPESMEKRRSRESLNMDVVKYESGPDGGEEA
InterPro domains: - IPR002151: Kinesin light chain (family) [5-520]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [191-496]
- IPR019734: Tetratricopeptide repeat (repeat) [211-496]
Interaction partners: - Kinesin-1 heavy chain
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Kinesin light chain 2
- C-Jun-amino-terminal kinase-interacting protein 3
- Kinesin light chain 4
- C-Jun-amino-terminal kinase-interacting protein 1
- Kinesin light chain 3
- Calsyntenin-1
- Glycogen synthase kinase-3 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0031503 (protein-containing complex localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0033036 (macromolecule localization), GO:0097722 (sperm motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0120316 (sperm flagellum assembly), GO:0051649 (establishment of localization in cell), GO:0030317 (flagellated sperm motility), GO:0007283 (spermatogenesis), GO:0045184 (establishment of protein localization), GO:0007018 (microtubule-based movement), GO:0099118 (microtubule-based protein transport), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0071705 (nitrogen compound transport), GO:0003341 (cilium movement), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0071702 (organic substance transport), GO:0007286 (spermatid development), GO:0099111 (microtubule-based transport), GO:0022607 (cellular component assembly), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0008088 (axo-dendritic transport), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060294 (cilium movement involved in cell motility), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0044458 (motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0005929 (cilium), GO:0030425 (dendrite)