Protein: Rhomboid-related protein 1 (RRP) (EC 3.4.21.105) (Rhomboid-like protein 1) (O75783)
Organism: Homo sapiens (Human)
Function: May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPALWSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNEQGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAVFWNVFAYDLLGAHIPPPP
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [77-134]
- IPR035952: Rhomboid-like superfamily (homologous_superfamily) [193-402]
- IPR051739: Rhomboid-related Intramembrane Serine Proteases (family) [74-427]
- IPR022764: Peptidase S54, rhomboid domain (domain) [244-393]
Interaction partners: - Rhomboid-related protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0016486 (peptide hormone processing), GO:1901564 (organonitrogen compound metabolic process), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0050886 (endocrine process), GO:0032101 (regulation of response to external stimulus), GO:0043603 (amide metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0003013 (circulatory system process), GO:0031347 (regulation of defense response), GO:0050727 (regulation of inflammatory response), GO:0006518 (peptide metabolic process), GO:0006508 (proteolysis), GO:0008015 (blood circulation), GO:0003073 (regulation of systemic arterial blood pressure), GO:0051604 (protein maturation), GO:0001990 (regulation of systemic arterial blood pressure by hormone), GO:0010467 (gene expression), GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin), GO:0003044 (regulation of systemic arterial blood pressure mediated by a chemical signal), GO:0016485 (protein processing), GO:0001991 (regulation of systemic arterial blood pressure by circulatory renin-angiotensin), GO:0140448 (signaling receptor ligand precursor processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)