Protein: Utx histone demethylase, isoform D (EC 1.14.11.68) (M9MRG4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGQLTFEDDCLIRELDSRYYGFLDLSNSKNAELRNLVQQTITNLQNYIANGQVHESKNSSDNKNAIQKFEPSTQAGEHMENTSSRNNDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGHLHLLLGEYSEALSAYQKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKHCGEFHIALKHLQLALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQLRDAYACYLNATKQISFQSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLCSIEEAWNLPISLEMNSRQQQTAQMLPRQVTKQSPVQGPPPPYPHSQLSQSPIPSKRIKEDGTSQQEVTQNNSQTSAQNLINISESLNQRNFNAMPESNKSSEQSVLDTFDDISNDIYKQNESIKLERLSQDALSNNEDSRHDFIGGDNADISTTFKIQMDSKQLMVAVKLLPIDEPPVHCTILQVNAPPPSPPDCPPQKLTRDQLLPPTPSVHLENKKHAFSPQLQEFCLKHPIAVVRGLAGVLKLDLGLFSTKTLVEANPDHSVEVRTQVHQSPDENWDTSQGKRVWACISHRSHTTIAKYAQYQASSFQDSLKDESDKGFPGSQAMSDSDSKDSVSNSNIVLKRKKHKINSKMLRFGTNVDLSDEKKWKPQLTELQKLPAFARVISAANMLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGGVHNLCEKNNISYLHGSWWPVLEDLYKENIPVYRFIQKPGDLVWVNAGCVHWVQSIGWCNNIAWNVGPLTARQYSLAIERYEWNKVQAFKSIVPMVHLSWNLARNIKVSDTKLFELIKMCLLQTLKNVLHIQEYVKSKGVEIRFNGRGKNEASHYCGQCEVEVFNVLFIKEQEKRHVVHCLSCALKLSPSLQGIVCLEEYRLSELQRVYDSFTLHRTQGLAYTQ
InterPro domains: - IPR046941: Lysine-specific demethylase 6, GATA-like domain superfamily (homologous_superfamily) [1044-1107]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [93-428]
- IPR051630: Transcriptional Corepressor and Histone Demethylase (family) [40-1121]
- IPR019734: Tetratricopeptide repeat (repeat) [114-407]
- IPR003347: JmjC domain (domain) [826-989]
- IPR048562: Lysine-specific demethylase 6A/B-like, C-terminal helical domain (domain) [979-1033]
- IPR048560: Lysine-specific demethylase 6A/B-like, GATA-like (domain) [1052-1108]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0003682 (chromatin binding), GO:0003712 (transcription coregulator activity), GO:0032451 (demethylase activity), GO:0016491 (oxidoreductase activity), GO:1990841 (promoter-specific chromatin binding), GO:0140457 (protein demethylase activity), GO:0003713 (transcription coactivator activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity), GO:0032452 (histone demethylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060033 (anatomical structure regression), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009791 (post-embryonic development), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0002165 (instar larval or pupal development), GO:0010942 (positive regulation of cell death), GO:0007552 (metamorphosis), GO:0012501 (programmed cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009611 (response to wounding), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0035070 (salivary gland histolysis), GO:0009891 (positive regulation of biosynthetic process), GO:0009887 (animal organ morphogenesis), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010623 (programmed cell death involved in cell development), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0071478 (cellular response to radiation), GO:0097305 (response to alcohol), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0036314 (response to sterol), GO:0043067 (regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043068 (positive regulation of programmed cell death), GO:0006974 (cellular response to DNA damage stimulus), GO:0007423 (sensory organ development), GO:0048707 (instar larval or pupal morphogenesis), GO:0048732 (gland development), GO:0006325 (chromatin organization), GO:0010628 (positive regulation of gene expression), GO:0048102 (autophagic cell death), GO:0035272 (exocrine system development), GO:0035071 (salivary gland cell autophagic cell death), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0042060 (wound healing), GO:0051254 (positive regulation of RNA metabolic process), GO:0033993 (response to lipid), GO:0043620 (regulation of DNA-templated transcription in response to stress), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0014070 (response to organic cyclic compound), GO:0010212 (response to ionizing radiation), GO:0022612 (gland morphogenesis), GO:1901701 (cellular response to oxygen-containing compound), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1901655 (cellular response to ketone), GO:0007431 (salivary gland development), GO:0036315 (cellular response to sterol), GO:0071479 (cellular response to ionizing radiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045815 (transcription initiation-coupled chromatin remodeling), GO:0010332 (response to gamma radiation), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0040029 (epigenetic regulation of gene expression), GO:0007435 (salivary gland morphogenesis), GO:0006338 (chromatin remodeling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0035075 (response to ecdysone), GO:0043618 (regulation of transcription from RNA polymerase II promoter in response to stress), GO:0097306 (cellular response to alcohol), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0071390 (cellular response to ecdysone), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0071480 (cellular response to gamma radiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0000791 (euchromatin), GO:1990234 (transferase complex), GO:0035097 (histone methyltransferase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0043227 (membrane-bounded organelle), GO:0005705 (polytene chromosome interband), GO:0043228 (non-membrane-bounded organelle), GO:0044666 (MLL3/4 complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0005700 (polytene chromosome)