Protein: Growth arrest and DNA damage-inducible protein GADD45 alpha (A0A087WZQ0)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER
InterPro domains: - IPR004038: Ribosomal protein eL8/eL30/eS12/Gadd45 (domain) [21-99]
- IPR029064: Ribosomal protein eL30-like superfamily (homologous_superfamily) [1-147]
- IPR024824: Growth arrest and DNA damage-inducible protein GADD45 (family) [49-147]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0019900 (kinase binding), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007017 (microtubule-based process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0080134 (regulation of response to stress), GO:0007051 (spindle organization), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0000226 (microtubule cytoskeleton organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0051726 (regulation of cell cycle), GO:2001022 (positive regulation of response to DNA damage stimulus), GO:0007059 (chromosome segregation), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:2001235 (positive regulation of apoptotic signaling pathway), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0010468 (regulation of gene expression), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:1901988 (negative regulation of cell cycle phase transition), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0031399 (regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway), GO:0007010 (cytoskeleton organization), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0043410 (positive regulation of MAPK cascade), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade), GO:0042325 (regulation of phosphorylation), GO:0046328 (regulation of JNK cascade), GO:0001932 (regulation of protein phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032874 (positive regulation of stress-activated MAPK cascade), GO:0046330 (positive regulation of JNK cascade), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016604 (nuclear body), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)