Protein: Transcription elongation factor TFIIS (Protein REDUCED DORMANCY 2) (Q9ZVH8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites (Probable). Involved in the control of seed dormancy and germination.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000269|PubMed:19150360}.
Sequence: MESDLIDLFEGAKKAADAAALDGVTSSGPEVSQCIDALKQLKKFPVTYDTLVATQVGKKLRSLAKHPVEDIKSVATDLLEIWKKVVIEETAKAKKTEGTNGCKEAKVNKMDVEKPSNPAPVKVQKLQRGDSAKSIKVERKEPDNKVVTGVKIERKVPDIKVTNGTKIDYRGQAVKDEKVSKDNQSSMKAPAKAANAPPKLTAMLKCNDPVRDKIRELLVEALCRVAGEADDYERESVNASDPLRVAVSVESLMFEKLGRSTGAQKLKYRSIMFNLRDSNNPDLRRRVLTGEISPEKLITLSAEDMASDKRKQENNQIKEKALFDCERGLAAKASTDQFKCGRCGQRKCTYYQMQTRSADEPMTTYVTCVNCDNHWKFC
InterPro domains: - IPR036575: Transcription elongation factor S-II, central domain superfamily (homologous_superfamily) [181-308]
- IPR017923: Transcription factor IIS, N-terminal (domain) [10-89]
- IPR035441: TFIIS/LEDGF domain superfamily (homologous_superfamily) [1-101]
- IPR001222: Zinc finger, TFIIS-type (domain) [336-377]
- IPR035100: Transcription elongation factor, IIS-type (family) [2-378]
- IPR006289: Transcription elongation factor, TFIIS (family) [11-378]
- IPR003618: Transcription elongation factor S-II, central domain (domain) [207-333]
- IPR003617: Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type (domain) [8-88]
Interaction partners: - Transcription elongation factor SPT4 homolog 2
- Transcription initiation factor IIB-1
- Transcription elongation factor SPT6 homolog
- DNA-directed RNA polymerase II subunit 4
- FACT complex subunit SPT16
- DNA-directed RNA polymerase II subunit 2
- DNA-directed RNA polymerase II subunit RPB1
- DNA-directed RNA polymerases II, IV and V subunit 11
- FACT complex subunit SSRP1
- Mediator of RNA polymerase II transcription subunit 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)