Protein: Acyl-CoA-binding protein (ACBP) [Cleaved into: SDF-2] (Q5FXM5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to acyl-CoA. Processed into the SDF-2 (spore differentiation factor 2) a peptide which triggers sporulation. SDF-2 appears to stimulate prestalk cells to release additional SDF-2 by acting through a signal transduction pathway that also involves dhkA, regA and PKA. Induces encapsulation of prespore cells in a dhkA-dependent manner. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor and is also able to inhibit induction of sporulation by SDF-2.
Sequence: MTTFEEAAQKVKEFTKKPSNDELLSLYGLYKQGTDGDCNISEPWAVQVEAKAKYNAWNALKGTSKEDAKAKYVALYEQLATKYA
InterPro domains: - IPR022408: Acyl-CoA-binding protein, ACBP, conserved site (conserved_site) [18-36]
- IPR000582: Acyl-CoA-binding protein, ACBP (domain) [1-84]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [1-84]
- IPR035984: Acyl-CoA binding protein superfamily (homologous_superfamily) [3-83]
Interaction partners: - Golgi reassembly stacking protein
- Serine protease/ABC transporter B family protein tagC
- Hybrid signal transduction histidine kinase A
- 3',5'-cyclic-nucleotide phosphodiesterase regA
- Hybrid signal transduction histidine kinase B
- acetyl-CoA C-acyltransferase
- Peroxisomal acyl-coenzyme A oxidase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0008289 (lipid binding), GO:1901681 (sulfur compound binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0033218 (amide binding), GO:0097367 (carbohydrate derivative binding), GO:1901265 (nucleoside phosphate binding), GO:1901567 (fatty acid derivative binding), GO:0120227 (acyl-CoA binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0000062 (fatty-acyl-CoA binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0000038 (very long-chain fatty acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0042761 (very long-chain fatty acid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)