Protein: receptor protein-tyrosine kinase (EC 2.7.10.1) (A0A0G2K2H0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MGRVPLAWCVALCCWGCAAPKDTQTEADSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVMWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVAGYSFQHSLQAPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHNLHVVSRHPTELEVAWIPSLSGIYPLTHCTLQAVLSDDGVGVWLGESDPPEEPLTVQVSVPPHQLRLEKLLPHTPYHIRVSCTSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQALVRWQEPREPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVAAYTSAGDGPWSLPVPLEPWRPVSEPPPPAFSWPWWYVLLGALVAAACVLILTLFLVHRRKKETRYGEVFEPTVERGELVVRYRARKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPLDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDSCSCLTEADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [513-803]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [218-415]
- IPR050122: Receptor Tyrosine Kinase (family) [72-793]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [25-218]
- IPR003961: Fibronectin type III (domain) [219-422]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [28-419]
- IPR007110: Immunoglobulin-like domain (domain) [20-216]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [522-788]
- IPR017441: Protein kinase, ATP binding site (binding_site) [527-552]
- IPR003599: Immunoglobulin domain subtype (domain) [35-218]
- IPR000719: Protein kinase domain (domain) [521-792]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [653-665]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [521-788]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0043548 (phosphatidylinositol 3-kinase binding), GO:0019838 (growth factor binding), GO:0017022 (myosin binding), GO:0032036 (myosin heavy chain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048771 (tissue remodeling), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0010035 (response to inorganic substance), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0009611 (response to wounding), GO:0006979 (response to oxidative stress), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0042246 (tissue regeneration), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0034599 (cellular response to oxidative stress), GO:0031100 (animal organ regeneration), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0062197 (cellular response to chemical stress), GO:0042542 (response to hydrogen peroxide), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0048678 (response to axon injury), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0034614 (cellular response to reactive oxygen species), GO:0070301 (cellular response to hydrogen peroxide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)