Protein: Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein) (P70288)
Organism: Mus musculus (Mouse)
Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR (By similarity). Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity (By similarity). May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. In addition to protein deacetylase activity, also acts as protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q92769}. Cytoplasm {ECO:0000250|UniProtKB:Q92769}.
Sequence: MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVAKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDPKGAKSEQLSNP
InterPro domains: - IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [8-381]
- IPR000286: Histone deacetylase HDAC (family) [138-265]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [10-374]
- IPR003084: Class I/II Histone deacetylase HDAC (family) [1-479]
- IPR023801: Histone deacetylase domain (domain) [29-319]
Interaction partners: - Chromodomain-helicase-DNA-binding protein 4
- Histone-binding protein RBBP7
- DNA helicase
- DNA
- Paired amphipathic helix protein Sin3a
- Lysine-specific histone demethylase 1A
- Histone deacetylase 1
- Histone deacetylase complex subunit SAP30
- Histone-binding protein RBBP4
- Histone-lysine N-methyltransferase EZH2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0031490 (chromatin DNA binding), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0140297 (DNA-binding transcription factor binding), GO:0003677 (DNA binding), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0042752 (regulation of circadian rhythm), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0007623 (circadian rhythm), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048638 (regulation of developmental growth), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0120161 (regulation of cold-induced thermogenesis), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0120162 (positive regulation of cold-induced thermogenesis), GO:1905208 (negative regulation of cardiocyte differentiation), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051726 (regulation of cell cycle), GO:1901360 (organic cyclic compound metabolic process), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0040014 (regulation of multicellular organism growth), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0032922 (circadian regulation of gene expression), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0010256 (endomembrane system organization), GO:0019438 (aromatic compound biosynthetic process), GO:0006325 (chromatin organization), GO:0051148 (negative regulation of muscle cell differentiation), GO:0043588 (skin development), GO:0051147 (regulation of muscle cell differentiation), GO:0051247 (positive regulation of protein metabolic process), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0010468 (regulation of gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0008544 (epidermis development), GO:0018130 (heterocycle biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0061024 (membrane organization), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044091 (membrane biogenesis), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:1905207 (regulation of cardiocyte differentiation), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0051154 (negative regulation of striated muscle cell differentiation), GO:0043009 (chordate embryonic development), GO:0016070 (RNA metabolic process), GO:0031399 (regulation of protein modification process), GO:0098732 (macromolecule deacylation), GO:2001141 (regulation of RNA biosynthetic process), GO:0098773 (skin epidermis development), GO:0051153 (regulation of striated muscle cell differentiation), GO:0006355 (regulation of DNA-templated transcription), GO:0035601 (protein deacylation), GO:0071709 (membrane assembly), GO:0007009 (plasma membrane organization), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0031401 (positive regulation of protein modification process), GO:0016570 (histone modification), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0001701 (in utero embryonic development), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0006476 (protein deacetylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0061436 (establishment of skin barrier), GO:0016575 (histone deacetylation), GO:0006351 (DNA-templated transcription), GO:0031396 (regulation of protein ubiquitination), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0006366 (transcription by RNA polymerase II), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0098687 (chromosomal region), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0005667 (transcription regulator complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0000792 (heterochromatin), GO:0070603 (SWI/SNF superfamily-type complex), GO:0000118 (histone deacetylase complex), GO:0043229 (intracellular organelle), GO:0017053 (transcription repressor complex), GO:0016581 (NuRD complex), GO:0043228 (non-membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043233 (organelle lumen), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000781 (chromosome, telomeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0090545 (CHD-type complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome)