Protein: Teneurin-2 (Ten-2) (Neurestin) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)] (Q9DER5)
Organism: Gallus gallus (Chicken)
Function: Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediate axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer.
Subcellular location: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Note=Localized at plasma membrane of neurites and growth cones. Enriched in cell-cell contact areas.; SUBCELLULAR LOCATION: [Ten-2 intracellular domain]: Nucleus, PML body. Note=Upon proteolytic cleavage, is translocated into the nucleus and accumulates within PML bodies.
Sequence: MDIKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPAQKSYSSSETLKAYGHDTRMHYGNRVSDLVHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDIGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSSRSSGLSSRENSALTLTDSDNENKSDEENDFHTHLSEKLKDRQTSWQQLAETKNSLIRRPIPPTSSSSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPSNHHSQSTLRPPLPPPHNHSLSHHHSSANSLNRNSLTNRRNQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGTTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRNAFKLKKPSKYCSWKCAALSAIAAAVLLAILLAYFIAMHLLGLNWQLQPADGHTFSNGLRPGAAGAEDGAAAPPAGRGPWVTRNSSIDSGETEVGRKVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEVVSFSTVILDSVQDCPRNCHGNGECVSGVCHCFPGFHGADCAKAACPVLCSGNGQYSKGTCLCYSGWKGPECDVPISQCIDPSCGGHGSCIEGNCVCSIGYKGENCEEVDCLDPTCSNHGVCVNGECLCSPGWGGINCELPRAQCPDQCSGHGTYLSDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGVACDQRVCHPRCTEHGTCKDGKCECREGWNGEHCTIGRQTTGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLVPDCCLQSTCQNSLLCRGSRDPLDIIQQSHSGSPAVKSFYDRIKLLVGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGMFDLVANGGSSLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPVIISSPLSTFFSDAPGRNPIVPETQVLHEEIEVPGSSIKLIYLSSRTAGYKSLLKIIMTQSLVPLNLIKVHLMVAVEGHLFQKSFLASPNLAYTFIWDKTDAYGQKVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHVLNVKSGILHKGNGENQFLTQQPAVITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLFVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYKVKSLTGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAVDATLMSPRGIAVDKYGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVSQVRLEWPTDLAVDPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYISETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDGYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNRPILNSFNQYEAASPGEQELYVFNADGIHQYTLSLVTGEYLYNFTYSSDNDVTEVMDSNGNSLKVRRDASGMPRHLLMPDNQIVTLAVGTNGGLKLVSTQTLELGLMTYNGNSGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMSISFHSEPHVLAGTVTPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTVFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQLGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIISRMFADGKVWSYTYLEKSMVLLLQSQRQYIFEYDSSDRLHAVTMPSVARHSMSTHTSVGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIASIKPIISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVTKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDIPYKIDDDGFLCQRGSDVFEYNSKGLLTRAYNKANGWNVQYRYDGLGRRASCKTNLGHHLQYFYADLHNPTRVTHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQLVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNIGREPAPFNLYMFKSNNPLSNELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVSPPYELTESQACENGQLITGVQQTTERHNQAFMALEGQVISKRLHASIREKAGHWFATSTPIIGKGIMFAVKKGRVTTGISSIATDDSRKIASVLNSAHYLEKMHYSIEGKDTHYFVKIGSADSDLVTLAMTSGRKVLDSGVNVTVSQPTLLINGRTRRFTNIEFQYSTLLINIRYGLTADTLDEEKARVLDQARQRALGSAWAKEQQKARDGREGSRVWTDGEKQQLLNTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR
InterPro domains: - IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [1298-1599]
- IPR022385: Rhs repeat-associated core (domain) [2419-2495]
- IPR008969: Carboxypeptidase-like, regulatory domain superfamily (homologous_superfamily) [960-1035]
- IPR001881: EGF-like calcium-binding domain (domain) [697-869]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [1304-1751]
- IPR057629: Teneurin-1-4-like, galactose-binding domain-like (domain) [474-597]
- IPR051216: Teneurin (family) [4-2797]
- IPR057627: Teneurin 1-4-like, FN-plug domain (domain) [1111-1195]
- IPR000742: EGF-like domain (domain) [603-869]
- IPR009471: Teneurin intracellular, N-terminal (domain) [1-403]
- IPR056823: Teneurin, YD-shell (domain) [1603-2512]
- IPR028916: Tox-GHH domain (domain) [2718-2795]
- IPR056820: Teneurin, TTR-like domain (domain) [952-1037]
- IPR056822: Teneurin, NHL domain (domain) [1236-1599]
- IPR006530: YD repeat (repeat) [1713-1751]
Interaction partners: - Adhesion G protein-coupled receptor L2
- Leucine-rich repeat transmembrane protein FLRT3
- Adhesion G protein-coupled receptor L3
- E3 ubiquitin-protein ligase TRIM71
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0050839 (cell adhesion molecule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:0032990 (cell part morphogenesis), GO:0031345 (negative regulation of cell projection organization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0010977 (negative regulation of neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0019898 (extrinsic component of membrane), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0019897 (extrinsic component of plasma membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0097060 (synaptic membrane), GO:0098890 (extrinsic component of postsynaptic membrane), GO:0099243 (extrinsic component of synaptic membrane), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0044309 (neuron spine)