Protein: V-type proton ATPase catalytic subunit A (Q5AJB1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Mediates oxidative stress response, filamentous growth, and plays an important role in virulence
Subcellular location: Vacuole membrane; Peripheral membrane protein; Cytoplasmic side
Sequence: MAGALENATKEIKRLSLEDTHESQYGQIYSVSGPVVVAENMIGCAMYELVKVGHDNLVGEVIRINGDKATIQVYEETAGVTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKDESQSIYIPRGIDVPALSRTTQYDFTPGKLKVGDHITGGDIFGSIYENSLLDDHKILLPPRARGTITSIAESGSYNVEDTVLEVEFDGKKHKYSMMHTWPVRVPRPVAEKLSADYPLLTGQRVLDSLFPCVQGGTTCIPGAFGCGKTVISQSLSKFSNSDVIIYVGCGERGNEMAEVLMEFPELYTEISGRKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKATALGSPDRIGSVSIVAAVSPAGGDFSDPVTTATLGITQVFWGLDKKLAQRKHFPSINTSVSYSKYTNVLNKYYDSNYPEFAQLRDKIREILSNAEELEQVVQLVGKSALSDSDKITLDVATLIKEDFLQQNGYSSYDAFCPIWKTFDMMRAFISYYDEAQKAVANGAQWSKLAESTSDVKHSVSSAKFFEPSRGQKEGEKEFSELLSTISERFAEASE
InterPro domains: - IPR020003: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (active_site) [453-462]
- IPR004100: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain (domain) [28-90]
- IPR036121: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily (homologous_superfamily) [21-93]
- IPR000194: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain (domain) [237-462]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [95-467]
- IPR031686: ATPsynthase alpha/beta subunit, barrel-sandwich domain (domain) [131-219]
- IPR024034: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal (homologous_superfamily) [463-617]
- IPR022878: V-type ATP synthase catalytic alpha chain (family) [18-616]
- IPR023366: ATP synthase subunit alpha, N-terminal domain-like superfamily (homologous_superfamily) [17-93]
- IPR055190: ATP synthase A/B type, C-terminal domain (domain) [470-570]
- IPR005725: ATPase, V1 complex, subunit A (family) [24-608]
Interaction partners: - V-type proton ATPase subunit H
- V-type proton ATPase subunit D
- V-type proton ATPase subunit B
- H(+)-transporting V0 sector ATPase subunit c
- V-type proton ATPase subunit
- V-type proton ATPase subunit C
- H(+)-transporting V1 sector ATPase subunit E
- V-type proton ATPase subunit G
- V-type proton ATPase proteolipid subunit
- V-type proton ATPase subunit F
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0042625 (ATPase-coupled ion transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0044769 (ATPase activity, coupled to transmembrane movement of ions, rotational mechanism), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046961 (proton-transporting ATPase activity, rotational mechanism), GO:0015078 (proton transmembrane transporter activity), GO:0009678 (pyrophosphate hydrolysis-driven proton transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)