wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cysteine-rich secretory protein LCCL domain containing 2 (A0A0G2JUW3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MSCLLNNMVPVGLALLVCGVQAFFLPNTMSLERLLSKYQHTEPHSRVRRAIPMSDRQEILMLHNKLRGQVYPPASNMEYMTWDEELERSAAAWAQRCLWEHGPASLLVSIGQNLAVHWGRYRSPGFHVQSWYDEVKDYTYPYPHECNPWCPERCSGAMCTHYTQMVWATTNKIGCAVHTCRSMSVWGDIWENAVYLVCNYSPKGNWIGEAPYKHGRPCSECPSSYGGGCRNNLCYRAEEHYHQKPEVDEMNEVESPPAPEETHVWVQPRVVKPSKTKKTPVVNFMTQVVHCDTKMKDSCKGSTCNRYQCPAGCLNNKAKVFGSLFYESSSSICRAAIHYGVIDDRGGLVDVTRNGMVPFFVKSQKNGLESLSKYKPSSSFTVSKVKETAVDCHTTVAQLCPFEKPATHCPRVRCPSRCGEEPSYWAPVYGTNIYADTSSICKAAVHAGVIVDEVGGYADVMPVDKKKSYVGSLRNGVQSESPSTPQNGNAFRIFPVRQ
InterPro domains: - IPR018244: Allergen V5/Tpx-1-related, conserved site (conserved_site) [195-206]
- IPR001283: Cysteine-rich secretory protein-related (family) [80-208]
- IPR051957: Cysteine-rich secretory LCCL domain-containing protein (family) [164-386]
- IPR004043: LCCL domain (domain) [285-489]
- IPR035940: CAP superfamily (homologous_superfamily) [34-245]
- IPR036609: LCCL domain superfamily (homologous_superfamily) [285-493]
- IPR014044: CAP domain (domain) [54-208]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0008201 (heparin binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0060324 (face development), GO:0060322 (head development), GO:0060323 (head morphogenesis), GO:0060325 (face morphogenesis), GO:0010171 (body morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: NCK adaptor protein 1 (H7C5C7)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: XVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKCDYIRPSLTGKFAGNPWYYGK
InterPro domains: - IPR039801: Epidermal growth factor receptor kinase substrate 8-like (family) [2-83]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [2-49]
- IPR001452: SH3 domain (domain) [1-49]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: C2 domain-containing protein (Q57WH0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSIFGEPLPHEDDTATSLIRREGFPPFSTYDQMPVHYACSCCAEINPSRGRNHLLRTAKQEKELEREKLMQINIIEERAKNPHPSIPRPRTSNLQRVMEDEELNQPAIPLPPTTLDELRKSRRQTNTTRLIVTVHHGKSINVDPRDPVSVLVRCGAFEGQTAKVPRGRSAICTWEELFEFPYPNEEEGLEVLVVDDTLPAENDHMFGGIVVPPHALRNRARGDEETLPVCAAGEMHRSYGRMKETPMGSIVVSWYVKRDGEDDADGAALKQNLEGGPINCNFVVHRLFQYTDNGALPYNGGVLCLLRDTDDNCSESGLYTFNSEGAMSSSPYYGKGGCTYLPQDRSQMLQLITPKKLGHVLICVTKDEVENEEDEELIVVGAVPLDFEKLYHKGSAVLLVESKVKEDVLWGEIAVEWGIISYATIQKSNEEDRQGTQMSNDRTGQRDGSGPRESLFLTVVRGLNLTDREGEPLAQGQVSVFACDMEGSTYSAPAVVEADGLAHVITWNQEVRFIEMDGGQAFIDVQVLDDKRIVSSGRFELLNDSDALTVKMHDPQNETVKRGEILVSYKLIRSTEEDDGESKRELSNEKEEEGSSPRRGASGRSGRGGSKRQSEMRSDQLSSRRNEDGSEYASDSREKSAEKGRSAREKSPSKQRSQKRSPRSSRKSNSKGSTARQTSRSPKSTSPKRNEEEGGRYLDELDEQQVKSAEDGRSPKERPLSKRSEEERGSDRFNESAAKSAEDDRSAQDKPLSKRNEENEDLEELDEQQVKSAEDDRSAQERPLSKRSEEERGSDRFNESAAKSAEDDRSAQDKPLSKRNEEDEDLEELDDPQGHAAEDEQHPSGGERKKKRSPKESEKSRKSPKEGKEKRSPRETTGKSKEESEKSRKSPKEGKEKRSPRETTGKSKEGSEKSRKSPKKSKEKRTPTEAAGKSADEEGYGDDGPLSKRTAEEESLEELDEPQGLAGADERYPVKEDEYTRSPKELAEEDLEELDEPKAEEPTEEQPLSKRNEEGGERLSSKGSEGRFEKEGGKEQRTVKLDVPPTPSPDRKPPIGKGDERSAKKKAASQGGSEKRSGSGKKPVSPEAATKKGRLSGQRDSAENVRGRGDSAGRTRAAEGKPSTSEAESSDVGAAANTRNRSPRSSVRRPSERLDEHNFSISPGASLTSGNWQPWHPTKNASNEDHIPLEKRTTFRNRTETIKQLEMRSRDSRLSSGHPSGNRDSSRRASTNRESSVGRGF
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [124-217]
- IPR000008: C2 domain (domain) [111-227]
Interaction partners: - Telomerase-associated protein, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0060285 (cilium-dependent cell motility), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0035869 (ciliary transition zone), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)
Protein: GATA zinc finger protein (Q5BPJ1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MRPPYNSFQPQARPYRPQHQLQQQQQINGFSNHQQQQHNGYQNPMNANQLGMMNPQMMNNPMMGHNMPMPNMPIHPQFFNNMPQQLPQFAMPNHINQLLPNLLGNLQFAVANSNLMGHSLPNFFQPSLEPHAFSSRPQLNSFNSLPYPPVPNPHQNHQSGPPGFSEPRPQGQSVDNTNGSGPNGNDFRNKFPKHQNFKGPGQGFQRPQLHQADNGKRKSGFNKDHRGKGNNNKMKTGLDGSDTGNIAKEKKRSYALMYTPREVQQWREARRKNYPTKFLVEKKVKKNVSASILDEEAKMRRQQLREVLAKQAELGVEVAEVPSHYLSNNDEQVNGDRGNNNGRKGRFQNNRRNKRRHDRKDKFDNKKPRLEDKKSSQDSSITTRKPTLLEKLLSADIKRDKSQLLQVFRFMVMNSLLKEFPEQPLKLPLITVKETGCEDAMEDPSIEGLCDGLSDGDDVDGDDSSCDEDV
InterPro domains: - IPR039136: NUFIP1-like (family) [1-441]
- IPR019496: FMR1-interacting protein 1, conserved domain (domain) [242-291]
Interaction partners: - 30-kDa cleavage and polyadenylation specificity factor 30
- Cleavage and polyadenylation specificity factor subunit 1
- Cleavage and polyadenylation specificity factor subunit 3-I
- Cleavage and polyadenylation specificity factor subunit 2
- Nucleolin 1
- 18S rRNA
- Small ribosomal subunit protein uS9c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0016043 (cellular component organization), GO:0048229 (gametophyte development), GO:0044085 (cellular component biogenesis), GO:0048235 (pollen sperm cell differentiation), GO:0030154 (cell differentiation), GO:0009555 (pollen development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0006997 (nucleus organization), GO:0007000 (nucleolus organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: PRADC1-like protein (PAP21-like protein) (Q9W1W9)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in iversification of muscle cell fates.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q9BSG0}.
Sequence: MLIAWLVLAATLSRSIRASTTISIPITTQDIIAGDVFFEILSPSELEYTYRLRPAKDFGSAFSERLEGVPLVITDPPGACQEIRNARDLNGGVALIDRGECSFLTKTLRAEAAGALAAIITEYNPSSPEFEHYIEMIHDNSQQDANIPAGFLLGKNGVIIRSTLQRLKRVHALINIPVNLTFTPPSKINHPPWLGW
InterPro domains: - IPR037323: PRADC1-like protein, PA domain (domain) [57-176]
- IPR003137: PA domain (domain) [70-157]
- IPR046450: PA domain superfamily (homologous_superfamily) [87-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006413 (translational initiation), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0002183 (cytoplasmic translational initiation), GO:0006518 (peptide metabolic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: F-box protein PP2-B1 (Protein PHLOEM PROTEIN 2-LIKE B1) (AtPP2-B1) (SKP1-interacting partner 21) (Q6NPT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MEQIHGGDSNSGGGGGGSSRNDEISVTRASRFDALPEDCISKVISHTSPRDACVVASVSKSVKSAAQSDLVWEMFLPSEYSSLVLQSANHLSKKEIFLSLADNSVLVENGKKSFWVEKASGKKCYMLSAMELTIIWGDSPAYWKWITVPESKFEKVAELRNVCWFEVRGKISCGMLSKGTHYSVYVVFKTANGRSYGFDLVPVEAGVGFVGKVATKKSVYFESGNADSRSATSHYSGISYAMVSRAFRMRRPWMQVQREEEEEVEGERERGMNVVGPKERVDGWSEVELGKFYINNGGCGDDGSDEIEISIMETQNGNWKSGLIIQGIEIRPERSN
InterPro domains: - IPR001810: F-box domain (domain) [29-75]
- IPR025886: Phloem protein 2-like (family) [122-332]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [30-127]
Interaction partners: - Protein PHLOEM PROTEIN 2-LIKE A2
- Protein PHLOEM PROTEIN 2-LIKE A9
- Immune-associated nucleotide-binding protein 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0010073 (meristem maintenance), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0051302 (regulation of cell division), GO:0099402 (plant organ development), GO:0016043 (cellular component organization), GO:0009798 (axis specification), GO:0044085 (cellular component biogenesis), GO:1905392 (plant organ morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048638 (regulation of developmental growth), GO:0048364 (root development), GO:0048507 (meristem development), GO:0010015 (root morphogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007010 (cytoskeleton organization), GO:0048366 (leaf development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protocadherin gamma subfamily A, 8 (Q6PHX8)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Sequence: MAASKNQHRHGRLVLLCTLMGTLCKISVGQIRYSVPEETDKGTVVGNISKDLGLEPRELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELCAQSTPCLVNINILVEEKGKLFGVEIEITDINDNNPKFHVGDLEVKINEIAAPGARYPLPEAVDPDVGINSLQSYQLSPNRHFSLHLQTGDDGTINPELVLERTLDREEEPTHHLVLTASDGGEPRRSSTALIQITVLDTNDNAPVFDQPVYRVKVLENVAPGTLLLTVRASDPDEGVNGKVTYKFRKINEKQSLLFHLHGNTGEMTVAKNLDYEECSLYEMEIQAEDVGALLGRSKVIIMVEDVNDNRPEVTITSLFNPVLENSLPGTVIAFLNVHDQDSGKNGQVVCYTHDNLPFKLEKSIDNYYRLVTWKYLDREKVSTYNITVIASDLGAPPLSTETYIALTVADTNDNPPRFSHTSYTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSVSEDTIQGVPLSSYISINSDTGILYALQSFDFEKIQDLQLLVIATDSGSPPLSSNVSLSLFVLDQNDNAPEILYPSFPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDALKQNLVMAVQDHGQPPLSATVTLTVAVANSIPEVLADLSSIMTPEVPEDSDLTLHLVVAVAVVSCVFLVFVIVLLALRLQRWQKSRQLQGSRSGLAPAPPSHFVGIDGVQAFLQTYSHEVSLTSGSQTSHIIFPQPNYADMLINQESCEKNDSLLTSIDFHENKDEDACAPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [16-823]
- IPR002126: Cadherin-like (domain) [31-683]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [811-932]
- IPR032455: Cadherin, cytoplasmic C-terminal domain (domain) [688-772]
- IPR013164: Cadherin, N-terminal (domain) [30-112]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [28-665]
- IPR020894: Cadherin conserved site (conserved_site) [230-560]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0043933 (protein-containing complex organization), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007041 (lysosomal transport), GO:0071825 (protein-lipid complex subunit organization), GO:0048284 (organelle fusion), GO:0008333 (endosome to lysosome transport), GO:0065005 (protein-lipid complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Major urinary protein 18 (Major urinary protein 4 like 4) (A0A8I6AMI2)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MKLLLLLLCLGLTLVCGHAEEANSKRGNLDVDKLNGDWFSIVVASNKREKIEENGSMRVFMQHIDVLENSLGFKFRIKENGECRELYLVAYKTPEDGEYFVEYDGGNTFTILKTDYDRYVMFHLVNFKNGETFQLMELYGRTKDLSSDIKEKFAKLCVAHGITRDNIIDLTKTDRCLQARG
InterPro domains: - IPR012674: Calycin (homologous_superfamily) [16-181]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [35-174]
- IPR022272: Lipocalin family conserved site (conserved_site) [28-41]
- IPR002345: Lipocalin (family) [6-177]
- IPR002971: Major urinary protein (family) [18-177]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005549 (odorant binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3) (Q5JTY5)
Organism: Homo sapiens (Human)
Function: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1C to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
Sequence: MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT
InterPro domains: - IPR011629: Zinc chaperone CobW-like, C-terminal (domain) [274-377]
- IPR051316: Zinc-regulated GTPase metalloprotein activator (family) [36-376]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [40-257]
- IPR003495: CobW/HypB/UreG, nucleotide-binding domain (domain) [43-229]
- IPR036627: CobW-like, C-terminal domain superfamily (homologous_superfamily) [256-375]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140104 (molecular carrier activity), GO:0016530 (metallochaperone activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0042802 (identical protein binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006882 (intracellular zinc ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Serine-repeat antigen protein 6 (EC 3.4.22.-) (Cysteine protease SERA6) (Q9TY96)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Cysteine protease which plays an essential role in merozoite egress from host erythrocytes. May cleave host SPTB/beta spectrin and ANK1/ankyrin-1 which disrupts host erythrocyte actin cytoskeleton and leads to host erythrocyte cell membrane rupture.
Subcellular location: Parasitophorous vacuole lumen {ECO:0000269|PubMed:22984267}. Parasitophorous vacuole membrane {ECO:0000269|PubMed:22984267}; Peripheral membrane protein {ECO:0000305}.
Sequence: MICPIFFLYIINVLFTQYFIKCEGNKVTVISHNNGHNDNLDVNKNGVISQENVFDTSESLNLPSNKKVGSDDLNTTTISFTVPDNLENEVKVVSSSESGKGATVSHTKVTSEGLSDTQPNVTQSVSSSTHTPGSLDSTMSTEQHSSVSQSSLPTESSSETLNKATVPEIPIQINSGLLKNYNGVKVTGSCGSYFRVYLVPHILIYALTKYSVIQLESLFNDNARIDVEHKGELQNKCSEGYHFKLVVYITHNVLNLKWKTYKPNEESKSEDSDVRKYRIPKLERPFTSIQVYTANSKAGVIETKNYNIRTDIPDTCDAIATDCFLNGNVNIEKCFQCTLLVQKKDKSHECFKYVSSEMKKKMNEIKVKAQDDFNPNEYKLIESIDNILSKIYKKANKPFEISKDLINLEDLDYQFKNELLEYCKLLKKVDTSGTLEEYELGNAEDIYNNLTRLLKSHSDENIVTLQGKLRNTAICIKNVDEWILNKRGLTLPSESPSESSSKSDSYLNTFNDKDKNEDKDDMSKNSKEEFKNDDKENSDDQNNNDSNKKDDENNINNGDTNYVYDFDDDDYDNNSYEKDMYESPIKENKNGVIDLEKYGNQIKLKSPYFKNSKYCNYEYCNRWRDKTSCISQIEVEEQGNCGLCWIFASKLHFETIRCMRGYGHFRSSALYVANCSKRKPIDRCEEGSNPLEFLRILDEKKFLPLESNYPYSYTSAGNSCPKLPNSWTNLWGDTKLLFNKKVHRYIGNKGFISHETSYFKNNMDLFIDMVKREVQNKGSVIIYIKTQDVIGYDFNGKGVHSMCGDRTPDHAANIIGYGNYINKKGEKRSYWLIRNSWSYYWGDEGNFRVDMLGPKNCLYNFIHTVVFFKLDLGTIHVPKKKSWKKNVYFLRHNPDFMYSLYYNNYEPETSQDFESENDYDNAFVHGQSNESDETNKEGKNVHNSVEKKIQILHILKHIKDSQIKRGLVKYDNINETKDEHTCSRVNSQDAEKYEECKKFCLTKWNECKDHYSPGYCLTDLYKGEDCNFCYV
InterPro domains: - IPR013128: Peptidase C1A (family) [526-849]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [617-868]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [638-649]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [575-870]
Interaction partners: - Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0050776 (regulation of immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043657 (host cell), GO:0043227 (membrane-bounded organelle), GO:0033643 (host cell part), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0020003 (symbiont-containing vacuole), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part)