Protein: Major intrinsically disordered Notch2-binding receptor 1 (Membrane integral NOTCH2-associated receptor 1) (Ubiquitination and mTOR signaling protein) (D3ZJ47)
Organism: Rattus norvegicus (Rat)
Function: Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. Negatively regulates angiogenesis (By similarity). Negatively regulates cell growth (By similarity). Negatively regulates neurite outgrowth in hippocampal neurons.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9UPX6}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9UPX6}.
Sequence: MEANQEASLFLVKILEELDSKQNTVSYQDLCKSLCAQFDLSQLAKLRSVLFYTACLDPNFPATLFKDKMKCSVNNQQSKKIMVAADIVTIFNLIQMNGGTAKEKLPTSCHKVRKEEASFESCRSDAEVCSPTVCEPLNCELSERPFSRGYPTRQSSKCRKMDCKECPQFVPASEPNFLLGVSKEVKNRAASLDRLQALSPYSVASPQPCEMQRTYFPMNIENESISDQDSLPIGQGIKETFISSEEPFMVQSCVQKRNIFKEDFHNLMTVSPSLVGTTNKAEEDHGEPRSQKELHKPPFFNHSFEMPYHSQYLNPVYSPIPDKRRAKHESLDDLQASTYFGPTPVMGTQDTRRCPGRPSKQTPWPAKSWSLNTEEVPDFERSFFNRNPSEEKLRYPNSGNQTPNFSGPDRHPVYLVPKDQQKVLPAGYAVKPNGLKSKEIPSPVDLEKHEAVKKFKDKSISCTSGQHSSDTSSVGTQTEQHVLDPPKCKDLCSAGQAKYSDRHAMKHSDDDSEIVSDDISDIFRFLDDMSISGSTGVIQSSCYNSTGSLSQLHKSDCDSSPEHNLAKITNGVSGSKGDKCNRPENVHHSEEELKSSVCKLVLRIGEIERKLESLAGVREEISQVLGKLNKLDQKIQQPEKVNVQIDLNSLTSEAPSDDSASPRVFHAHSGSHGPKLENSPDWCCSDVSGSNSESLRVKALKKSLFTRPSSRSLTEENSATESKIASISNSPRDWRTITYTNRMSLNEEEIKDAGPANNKDWHRKSKEADRQYDIPPQHRLPKQPKDGFLVEQVFSPHPYPSSLKAHMKSNPLYTDMRLTELAEVKRGQPSWNIEEYARNTGDKGKLTALDLQTQESLNPNNLEYWMEDIYTPGYDSLLKRKEAEFRRAKVCKIAALITAAACTVILVIVVPICTMKS
InterPro domains: - IPR055117: MINAR1, N-terminal helical domain (domain) [6-99]
- IPR039706: Major intrinsically disordered Notch2-binding receptor 1-like (family) [1-917]
- IPR009626: Major intrinsically disordered Notch2-binding receptor 1-like, C-terminal (domain) [760-915]
Interaction partners: - Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0009892 (negative regulation of metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009966 (regulation of signal transduction), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0060255 (regulation of macromolecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:1901343 (negative regulation of vasculature development), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:1901342 (regulation of vasculature development), GO:0045765 (regulation of angiogenesis), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0032006 (regulation of TOR signaling), GO:0031399 (regulation of protein modification process), GO:0032007 (negative regulation of TOR signaling), GO:0031400 (negative regulation of protein modification process), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903321 (negative regulation of protein modification by small protein conjugation or removal), GO:0031396 (regulation of protein ubiquitination), GO:0031397 (negative regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0045211 (postsynaptic membrane), GO:0045202 (synapse), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane)