wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Non-structural protein V (Q9EMA9)
Organism: Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Function: Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling (By similarity).
Subcellular location: Host cytoplasm {ECO:0000250}.
Sequence: MAEEQARHVKNGLECIRALKAEPIGSLAIEEAMAAWSEISDNPGQERATCREEKAGSSGLSKPCLSAIGSTEGGAPRIRGQGPGESDDDAETLGIPPRNLQASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSETPIKKGHRREISLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE
InterPro domains: - IPR028243: Paramyxovirus structural protein P/V, N-terminal domain (domain) [4-234]
- IPR024279: Paramyxovirinae protein V, zinc-binding domain (domain) [237-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019080 (viral gene expression), GO:0019083 (viral transcription), GO:0039695 (DNA-templated viral transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Receptor activity-modifying protein 1 (Q9WTJ5)
Organism: Mus musculus (Mouse)
Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O60894}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60894}.
Sequence: MAPGLRGLPRCGLWLLLAHHLFMVTACRDPDYGTLIQELCLSRFKENMETIGKTLWCDWGKTIQSYGELTYCTKHVAHTIGCFWPNPEVDRFFIAVHHRYFSKCPISGRALRDPPNSILCPFIALPITVTLLMTALVVWRSKRTEGIV
InterPro domains: - IPR038126: RAMP domain superfamily (homologous_superfamily) [20-112]
- IPR006985: Receptor activity modifying protein (family) [2-148]
Interaction partners: - Calcitonin receptor
- Calcitonin gene-related peptide type 1 receptor
- Calcitonin gene-related peptide 2
- Pro-adrenomedullin
- Islet amyloid polypeptide
- Receptor activity-modifying protein 3
- Receptor activity-modifying protein 2
- DNA-directed RNA polymerase III subunit RPC9
- Calcitonin
- Protein ADM2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0015026 (coreceptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Probable oxidoreductase (O33263)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MTSLQGKVVFITGAARGIGAEVARRLHNKGAKLVLTDLSKSELAVMGAELGGDDRLLTVVADVRDLPAMQAAAETAVERFGGIDVVVANAGIASYGSVLKVDPQAFRRVLDVNLLGNFHTVRATLPALIDRRGYVLIVSSLAAFAAPPGMAPYNMSKAGNEHFANALRLEVAHLGVSVGSAHMSWIDTALVRDTKADLPAFAELLARLPWPLNKTTSVNKCAAAFVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIRNTVAKLMPQMDAEVAALGRFASAYTESLENS
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1-258]
- IPR057326: Ketoreductase domain (domain) [7-188]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [7-197]
Interaction partners: - Probable short-chain type dehydrogenase/reductase
- L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity), GO:0008106 (alcohol dehydrogenase (NADP+) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:1901661 (quinone metabolic process), GO:0042181 (ketone biosynthetic process), GO:0006743 (ubiquinone metabolic process), GO:1901663 (quinone biosynthetic process), GO:0006744 (ubiquinone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Xrn1 N-terminal domain-containing protein (Q386Z9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MGTKGLRNYVEKHGLVRSSSRGRDGVVKRTNHLLLDMNAIVHYIVPTNVFTTKSVIEGVVEAVQKLISAFPPSETLVILFDGVAPCAKLQTQKTRRASYNKRHSSECTSSLELRYNHDYIGQEISFSREEIIAGSEFLLACEDAVRCAFGIGGEFCVPPGEGRNYTIIMSGCAEGGEGELKVVCVLRTIWLEQRKSQTYTGDDEIIVVGNDSDLVLVGVACTPYTKFTIVDPRDYALTDVGELFKHWGSSSPGNQIRPDLLPSYRIDFVFLMLLSGGDWFEGIGKVALVFWRRYRELRLHCGYFKRSLIRGEGFDVDIEFLRAVMAVKDVSSPAKYMSKIKQMTMKESPLSREAIEEGVELLKGAVWALRSIVAGQCYDYKFRAHTKKPTAGMLKGASHVKGLLGKIRPVSESPLPCFSPLEQCIAVLGLRGRFSSPIHMVIKEESVNQGEKLTNSFSSEFLLDETRRLMSQVKVDELTAAEQDLLQVRHMRFLESEDGKITFMSFHPEKQAVADVRVCDGGVK
InterPro domains: - IPR004859: Xrn1, N-terminal (domain) [24-228]
- IPR027073: 5'-3' exoribonuclease (family) [6-294]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0042162 (telomeric DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0030097 (hemopoiesis), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Actin depolymerizing factor (Q4JHK7)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Not known
Sequence: MANAASGMAVHDDCKLKFLELKAKRTYRFIVFKIEEKQKQVVVEKVGEPTDSYEAFTASLPADECRYAVYDFDFVTDENCQKSRIFFIAWSPDTSKVRSKMIYASSKDRFKRELDGIQVELQATDPSEMDLDVIRSRAN
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [1-139]
- IPR017904: ADF/Cofilin (family) [2-138]
- IPR002108: Actin-depolymerising factor homology domain (domain) [5-139]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0016049 (cell growth), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0000902 (cell morphogenesis), GO:0048316 (seed development), GO:0090378 (seed trichome elongation), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0009826 (unidimensional cell growth), GO:0048731 (system development), GO:0090376 (seed trichome differentiation), GO:0048608 (reproductive structure development), GO:0061458 (reproductive system development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0090558 (plant epidermis development), GO:0010026 (trichome differentiation), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cobalt-dependent inorganic pyrophosphatase (EC 3.6.1.1) (CBS domain-containing pyrophosphatase) (cpCBS-PPase) (Nucleotide-regulated inorganic pyrophosphatase) (Pyrophosphate phospho-hydrolase) (PPase) (Q8XIQ9)
Organism: Clostridium perfringens (strain 13 / Type A)
Function: Not known
Sequence: MKDVIYITGHKNPDSDSICAALAYAEFKNKTQDTPAIPVRLGNVSQETQYILDYFGVEAPQFLETVKLKVEDLEMDKIAPLAPEVSLKMAWNIMRDKNLKSIPVADGNNHLLGMLSTSNITATYMDIWDSNILAKSATSLDNILDTLSAEAQNINEERKVFPGKVVVAAMQAESLKEFISEGDIAIAGDRAEIQAELIELKVSLLIVTGGHTPSKEIIELAKKNNITVITTPHDSFTASRLIVQSLPVDYVMTKDNLVAVSTDDLVEDVKVTMSETRYSNYPVIDENNKVVGSIARFHLISTHKKKVIQVDHNERGQSVHGLEDAEVLEIIDHHRVADIQTGNPIYFRNEPLGSTSTIVAKRFFENGIRPSREAAGLLCGAIISDTLLFKSPTCTPQDVKMCRKLAEIAGIVPETFAKEMFKAGTSLKGKSIEEIFNADFKPFTIEGVKVGVAQVNTMDIEGFMPLKGEMLDYMNQKAESMGLEMIMLLLTDIINEGSQILVAGRSPEIAEEAFKVKLEDSTTFLPGVLSRKKQVVPPLTQIITTRVSK
InterPro domains: - IPR038763: DHH phosphoesterase superfamily (homologous_superfamily) [3-542]
- IPR038222: DHHA2 domain superfamily (homologous_superfamily) [426-547]
- IPR010766: DRTGG (domain) [142-244]
- IPR001667: DDH domain (domain) [5-382]
- IPR046342: CBS domain superfamily (homologous_superfamily) [68-300]
- IPR028979: HPr(Ser) kinase/phosphorylase-like, N-terminal domain superfamily (homologous_superfamily) [130-252]
- IPR004097: DHHA2 domain (domain) [417-543]
- IPR000644: CBS domain (domain) [70-310]
Interaction partners: - Putative pyrophosphatase PpaX
- ATP synthase subunit a
- Inosine-5'-monophosphate dehydrogenase
- ATP synthase subunit c
- V-type sodium ATP synthase subunit K
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009308 (amine metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006576 (biogenic amine metabolic process), GO:0009310 (amine catabolic process), GO:0042402 (cellular biogenic amine catabolic process), GO:0006595 (polyamine metabolic process), GO:0009445 (putrescine metabolic process), GO:0006598 (polyamine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Inner membrane protein YgaP (P55734)
Organism: Escherichia coli (strain K12)
Function: Not known
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Sequence: MALTTISPHDAQELIARGAKLIDIRDADEYLREHIPEADLAPLSVLEQSGLPAKLRHEQIIFHCQAGKRTSNNADKLAAIAAPAEIFLLEDGIDGWKKAGLPVAVNKSQPLPLMRQVQIAAGGLILIGVVLGYTVNSGFFLLSGFVGAGLLFAGISGFCGMARLLDKMPWNQRA
InterPro domains: - IPR001763: Rhodanese-like domain (domain) [6-105]
- IPR021309: Inner membrane protein YgaP-like, transmembrane domain (domain) [115-166]
- IPR036873: Rhodanese-like domain superfamily (homologous_superfamily) [2-154]
Interaction partners: - HTH-type transcriptional regulator YgaV
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0016783 (sulfurtransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0046417 (chorismate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Q9D8Y7)
Organism: Mus musculus (Mouse)
Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6P589}. Nucleus {ECO:0000250|UniProtKB:Q6P589}. Lysosome {ECO:0000250|UniProtKB:Q6P589}.
Sequence: MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALYGPDFTQHLGKICDGLRKLLDEGKL
InterPro domains: - IPR038355: Tumor necrosis factor alpha-induced protein 8-like superfamily (homologous_superfamily) [1-184]
- IPR008477: Tumor necrosis factor alpha-induced protein 8-like (family) [1-184]
Interaction partners: - Caspase-8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Large ribosomal subunit protein eL38 (60S ribosomal protein L38) (P63173)
Organism: Homo sapiens (Human)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23636399}.
Sequence: MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK
InterPro domains: - IPR038464: Large ribosomal subunit protein eL38 superfamily (homologous_superfamily) [1-70]
- IPR002675: Large ribosomal subunit protein eL38 (family) [1-69]
Interaction partners: - Large ribosomal subunit protein uL30
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS24
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein eS10
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0003735 (structural constituent of ribosome), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Growth hormone (H6UQ58)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613, ECO:0000256|RuleBase:RU003618}.
Sequence: MAPGSWFSPLLIAVVTLGLPQEAAATFPAMPLSNLFANAVLRAQHLHLLAAETYKEFERTYIPEDQRYTNKNSQAAFCYSETIPAPTGKDDAQQKSDMEVVRFSLVFIQSWLTPVQYLSKVFTNKLVFGTSDRVFEKLKDLEEGIQALMRELEDRSPRGPQLLRPTYDKFDIHLRNEDALLKNYGLLSCFKKDLHKVETYLKVMKCRRFGESNCTI
InterPro domains: - IPR018116: Somatotropin hormone, conserved site (conserved_site) [78-206]
- IPR034975: Somatotropin (family) [35-214]
- IPR001400: Somatotropin/prolactin (family) [4-214]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [20-214]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity), GO:0097153 (cysteine-type endopeptidase activity involved in apoptotic process)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0035295 (tube development), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009888 (tissue development), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0048731 (system development), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0061458 (reproductive system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0010628 (positive regulation of gene expression), GO:0060066 (oviduct development), GO:0060429 (epithelium development), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0042981 (regulation of apoptotic process), GO:0043066 (negative regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)