Protein: DNA damage-binding protein 1 (UV-damaged DNA-binding protein 1) (OsUV-DDB1) (Q6L4S0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (Probable). May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MSVWNYVVTAHKPTSVTHSCVGNFTGPNQLNLIVAKCTRIEIHLLTPQGLQPMIDVPIYGRIATLELFRPHNETQDFLFIATERYKFCVLQWDGEKSELLTRAMGDVSDRIGRPTDNGQIGIIDPDCRLIGLHLYDGLFKVIPFDNKGQLKEAFNIRLEELQVLDIKFLYGCVKPTIVVLYQDNKDARHVKTYEVALKDKDFVEGPWSQNNLDNGAGLLIPVPAPLGGVIIIGEETIVYCNANSTFRAIPIKQSIIRAYGRVDPDGSRYLLGDNAGILHLLVLTHERERVTGLKIEYLGETSIASSISYLDNGVVYVGSRFGDSQLVKLNLQADPNGSYVEVLERYVNLGPIVDFCVVDLDRQGQGQVVTCSGAFKDGSLRVVRNGIGINEQASVELQGIKGLWSLKSSFNDPYDMYLVVSFISETRFLAMNMEDELEETEIEGFDAQTQTLFCQNAINDLLIQVTANSVRLVSCTSRELVDQWNAPEGFSVNVASANASQVLLATGGGHLVYLEIKDSKLVEVKHIQLEHEISCVDLNPIGENPQYSSLAAVGMWTDISVRILSLPDLELIRKENLGGEIVPRSVLLCTLEGVSYLLCALGDGHLFSFLLNASTGELTDRKKVSLGTQPISLRTFSSKGTTHVFASSDRPTVIYSSNKKLLYSNVNLKEVNHMCPFNTAAIPDSLAIAKEGELSIGTIDDIQKLHIRTIPLNEQARRICHQEQSRTLAFCSFKHNQTSIEESETHFVRLLDHQTFEFLSIYQLDQYEHGCSIISCSFSDDNNVYYCVGTAYVLPEENEPSKGRILVFAVEDGRLQLIVEKETKGAVYSLNAFNGKLLAAINQKIQLYKWMLREDGSHELQSECGHHGHILALYTQTRGDFIVVGDLMKSISLLVYKHEESAIEELARDYNANWMSAVEMLDDEIYIGAENNYNIFTVRKNSDAATDEERGRLEVVGEYHLGEFVNRLRHGSLVMRLPDSEMGQIPTVIFGTINGVIGIIASLPHEQYVFLEKLQSTLVKFIKGVGNLSHEQWRSFHNDKKTSEARNFLDGDLIESFLDLSRNKMEEVAKGMGVPVEELSKRVEELTRLH
InterPro domains: - IPR004871: Cleavage/polyadenylation specificity factor, A subunit, C-terminal (domain) [746-1059]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [5-999]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [491-888]
- IPR018846: RSE1/DDB1/CPSF1, first beta-propeller domain (domain) [15-345]
- IPR050358: RSE1/DDB1/CFT1/CPSF1 (family) [5-1079]
Interaction partners: - Os04g0691200 protein
- Os01g0580300 protein
- Os03g0786800 protein
- Os03g0699100 protein
- Expressed protein
- COP9 signalosome complex subunit 5
- Os03g0187300 protein
- Os02g0307200 protein
- Os01g0857900 protein
- COP9 signalosome complex subunit 1, putative, expressed
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140535 (intracellular protein-containing complex), GO:0043229 (intracellular organelle), GO:1990234 (transferase complex), GO:0043227 (membrane-bounded organelle), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0080008 (Cul4-RING E3 ubiquitin ligase complex), GO:0005634 (nucleus)