Protein: Lumican (Keratan sulfate proteoglycan lumican) (KSPG lumican) (P51884)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Sequence: MSLSAFTLFLALIGGTSGQYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLN
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [33-338]
- IPR050333: Small Leucine-Rich Proteoglycans (family) [33-337]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [36-70]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [66-328]
- IPR001611: Leucine-rich repeat (repeat) [66-276]
Interaction partners: - Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Decorin
- Fibrillin-1
- Tumor necrosis factor ligand superfamily member 6
- Fibronectin
- Collagen alpha-2
- SPARC
- Collagen alpha-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0042303 (molting cycle), GO:0022404 (molting cycle process), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0022405 (hair cycle process), GO:0042633 (hair cycle), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0048513 (animal organ development), GO:0001942 (hair follicle development), GO:0009966 (regulation of signal transduction), GO:0030111 (regulation of Wnt signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0043588 (skin development), GO:0060429 (epithelium development), GO:0008544 (epidermis development), GO:0098773 (skin epidermis development), GO:0060828 (regulation of canonical Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030312 (external encapsulating structure), GO:0071944 (cell periphery), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043230 (extracellular organelle), GO:0030133 (transport vesicle), GO:0005773 (vacuole), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0005796 (Golgi lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0005775 (vacuolar lumen), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0005764 (lysosome), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0043202 (lysosomal lumen)