Protein: Sorting nexin-20 (Selectin ligand-interactor cytoplasmic 1) (SLIC-1) (Q7Z614)
Organism: Homo sapiens (Human)
Function: May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
Subcellular location: Early endosome membrane {ECO:0000269|PubMed:18196517}; Peripheral membrane protein {ECO:0000269|PubMed:18196517}; Cytoplasmic side {ECO:0000269|PubMed:18196517}. Cell membrane {ECO:0000269|PubMed:18196517}. Cytoplasm {ECO:0000269|PubMed:18196517}. Nucleus {ECO:0000269|PubMed:18196517}.
Sequence: MASPEHPGSPGCMGPITQCTARTQQEAPATGPDLPHPGPDGHLDTHSGLSSNSSMTTRELQQYWQNQKCRWKHVKLLFEIASARIEERKVSKFVVYQIIVIQTGSFDNNKAVLERRYSDFAKLQKALLKTFREEIEDVEFPRKHLTGNFAEEMICERRRALQEYLGLLYAIRCVRRSREFLDFLTRPELREAFGCLRAGQYPRALELLLRVLPLQEKLTAHCPAAAVPALCAVLLCHRDLDRPAEAFAAGERALQRLQAREGHRYYAPLLDAMVRLAYALGKDFVTLQERLEESQLRRPTPRGITLKELTVREYLH
InterPro domains: - IPR039937: Sorting nexin SNX20/SNX21 (family) [45-316]
- IPR001683: Phox homology (domain) [72-191]
- IPR036871: PX domain superfamily (homologous_superfamily) [59-194]
Interaction partners: - P-selectin glycoprotein ligand 1
- Headcase protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0035091 (phosphatidylinositol binding), GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0045184 (establishment of protein localization), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0016197 (endosomal transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0016482 (cytosolic transport), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0098927 (vesicle-mediated transport between endosomal compartments), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0007041 (lysosomal transport), GO:0006623 (protein targeting to vacuole), GO:0008333 (endosome to lysosome transport), GO:0006622 (protein targeting to lysosome), GO:0072665 (protein localization to vacuole), GO:0061462 (protein localization to lysosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane)