wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: SP9 (Q64HY4)
Organism: Gallus gallus (Chicken)
Function: Not known
Sequence: RRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHNGGGGGKKGSDSDTDASNLETPRSESPDLLLHDGAAAARGPGKEPPGGPGDS
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [33-117]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [46-102]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048736 (appendage development), GO:0009790 (embryo development), GO:0035107 (appendage morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0035108 (limb morphogenesis), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0030326 (embryonic limb morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: (thale cress) hypothetical protein (A0A384LCJ3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MDTVNDSFSPGSSRPSPATLSREDCWSEEATFTLIQAWGNRYVDLSRGNLRQKHWQEVANAVNDRHYNTGRNVSAAKSQPYRTDVQCKNRIDTLKKKYKVEKARVSESNPGAYISPWPFFSALDDLLRESFPTSSNPDSTDNIPHQRLSLPMSINPVPVAPRSAIPRRPATSPAIIPHAGDDLLGFRGNLNAFAAAAAAAACPASEDDSEGSRSRSSGRSGSNKKRERKIEKKQGYKEVADAIERLGQIYERVEEKKRKEMVELEKQRMRFAKELECHRMQLFTEMQVRLHKLRRTSGSKGPTSSASAALDYGMMDFPSYF
InterPro domains: - IPR044823: Trihelix transcription factor ASIL1/2-like (family) [17-296]
- IPR044822: Myb/SANT-like DNA-binding domain 4 (domain) [24-126]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82) (O54804)
Organism: Mus musculus (Mouse)
Function: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. May contribute to tumor cell growth.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35790}.; SUBCELLULAR LOCATION: [Isoform 1]: Lipid droplet {ECO:0000250|UniProtKB:P35790}. Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. {ECO:0000250|UniProtKB:P35790}.
Sequence: MKTKFCTGGEAEPSPLGLLLSCGGNAAPTPGVGQQRDAAGELESKQLGGRTQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELRLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKILSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSERRKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPSRKQQLHFISSYLTTFQNDFESLSSEEQFATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFEAYFDQKRKLGV
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [77-451]
Interaction partners: - Ethanolamine-phosphate cytidylyltransferase
- Choline-phosphate cytidylyltransferase A
- Choline-phosphate cytidylyltransferase B
- Glycerophosphocholine phosphodiesterase GPCPD1
- Choline O-acetyltransferase
- Ethanolamine-phosphate phospho-lyase
- Phosphoethanolamine/phosphocholine phosphatase
- Choline/ethanolamine kinase
- Acetylcholinesterase
- Choline/ethanolaminephosphotransferase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006629 (lipid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)
Protein: Abortive infection protein AbiGI (Q8DZ36)
Organism: Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Function: Not known
Sequence: MSKKEILLDFIEKNNGIVTNKDCKALGIPTIYLTRLEKEGIIFRVEKGIFLTQNGDYDEYYFFQYRFPKAIFSYISALYLQQFTDEIPQYFDVTVPRGYRFNTPPANLNIHFVSKEYSELGMTTVPTPMGNNVRVYDFERIICDFVIHREKIDSELFVKTLQSYGNYPKKNLAKLYEYATKMNTLEKVKQTLEVLI
InterPro domains: - IPR025159: Transcriptional regulator, AbiEi antitoxin (family) [5-51]
Interaction partners: - Abortive infection protein AbiGII
- SNF2 family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004519 (endonuclease activity), GO:0004521 (RNA endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Acyltransferase 3 domain-containing protein (Q9I1M7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
Sequence: MKKRWIQMDVTRGVGILIIVFGHSWFVASSPTVLYPLLSPFILPLFFFISGVFFRTEQPFGEMALRKADALLKPFFVTMLGYVILRDLLRGQPLLPDIGGVLYASVDTLPWQALWYLPHFWVATLFAWFMLRVIQRLGLSLAASCVLLAVQLGLGILFLKTFWQIPVEFGGEQYLLPGLPFSLDITLISSAHFMFGYVLRDVLRRHQSSLLTLCIALAVTTASFLYYPTVVDMAQRRYDHWFWATVQAVSGVYLCWALSGLMMKIDWLGKAMTYIGQSTLILLIFHGEIQHKTFNLLVHLGLSEPAAASVALVISVIVSLLIGEVIKRVALLRALYFPFPVRKKTAAVQGGGEAR
InterPro domains: - IPR052734: Nodulation factor acetyltransferase (family) [2-350]
- IPR002656: Acyltransferase 3 domain (domain) [7-322]
Interaction partners: - PslA
- PslJ
- PslH
- PslD
- PslF
- PslE
- PslI
- Alginate biosynthesis protein AlgA
- PslG
- FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0044042 (glucan metabolic process), GO:0006073 (cellular glucan metabolic process), GO:0009250 (glucan biosynthetic process), GO:0051273 (beta-glucan metabolic process), GO:0051274 (beta-glucan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (F1QJE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MGAYLSQPNTEKSTGNGGSKNLNYGFSAMQGWRVSMEDAHNCIPELDDETAMFAVYDGHGGEEVALYCSKYLPGIIKEQKTYKEGKLQKALEDAFLDIDARITTEEVIKELVQIAGRPQEETEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNQNKNAKKPCPEASKESEDGEKSHAEKGINGETECGPSVVDSIGKKPAGAGNAAEGSKMRACRRAAASGGSASEGSAEKSGDAGPSCSSSAAAPPGSAKSKFFEDSEESGEEEEEEEGSEEEDGSEEDGENSSENEEEDDTEEGEEEDTDEEEEMCLPGMDGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEKGKALDMSYDHKPEDELELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKALPAEEQMISALPDVKVLTLNDDHEFMVIACDGIWNVMSSQEVIDFVSERMKTESGKNNPLSAIIDELLDHCLAPDTSGDGTGCDNMTCMIVTFSPRSGSNVAEGTKKRKPEETAVEENGNDSKKPKTE
InterPro domains: - IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [1-503]
- IPR000222: PPM-type phosphatase, divalent cation binding (binding_site) [52-60]
- IPR015655: Protein phosphatase 2C (family) [20-499]
- IPR001932: PPM-type phosphatase-like domain (domain) [13-502]
Interaction partners: - E3 ubiquitin-protein ligase TRIP12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: DELLA protein GAI (GhGAI) (Gibberellic acid-insensitive mutant protein) (Q84TQ7)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Probably acts by participating in large multiprotein complexes that represses transcription of GA-inducible genes. Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MKRDHQEISGSGSNPAESSSIKGKLWEEDPDAGGMDDELLAVLGYKVRSSDMADVAQKLEMLEKVMGTAQEDGISQLGDTVHFNPSDLSGWVQNLLIEFNGSTTTPDPNFNDDSEYDLRAIPGVAAYPPVKSDPGLEITRKRAKTESSSSSSSTTTRPVVLIDSQEAGVRLVHTLMACAEAVQQDNLKLADALVKHIGLLASSQTGAMRKVATYFAEALARRIYRIFPPDSLDPSYNDKLQIPFYETCPYLKFAHFTANQAILEAFSMASRVHVIDFGLKQGMQWPALMQALALRPGGPPAFRLTGIGPPQPDNTDALQQVGWKLAQLAERIGIEFEFRGFVANSLADLEPEMLDIRPPEIEVVAVNAVFELHPLLARPGGIEKVVSSIKAMKPKIVTVVEQEANHNGPVFLDRFTEALHYYSTLFDSLEGSGVAPASQDLAMSELYLGRQICNVVACEGMDRVERHEPLTQWRTRMETAGVSPVHLGSNAYKQASMLLALFASGDGYRVEENNGCLMLGWHTRPLIAHLGLATRWY
InterPro domains: - IPR005202: Transcription factor GRAS (family) [148-533]
- IPR021914: Transcriptional factor DELLA, N-terminal (domain) [37-102]
- IPR038088: DELLA, N-terminal domain superfamily (homologous_superfamily) [34-99]
Interaction partners: - F-box protein GID2
- Flowering promoting factor 1
- Phytochrome
- Phytochrome
- Phytochrome
- Phytochrome
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Kinesin (Q583I7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MEASVGVEVAWSSEIVGSPQVGGYLQLVKQAQPVDVASDAVPSNTSDLVEGMSSSTSLSSVEMITTQHTRRFDGDGWKCVLDNHMVALCDVFVKDAAAACDVPLENVALRELRLGSLYVTFHVTHDADIDEEEIQQRVDLYPFREVMRLYANRDAPPDGVDALLKRNAELEAETKAMIARLKDENDKRIEKLIRDHEKALKDLQEKVDERERELVGINNDLEALLQQMTEQKNSLEEERKKAIEAIKRERARNEKLAHRNSELVAAIIQENKKEMEAKEREFEEQLLEKDVVIENLRAKLRTKNEATNGDVPHAGRSPMSNADPDRAEEFAKLMGRMEEMAIVLEKTQESETEARSEIQKLSEALKLSEEARQSDAVIYENNTLALKQQLQSFWDTKLAEDHQKRQEESRARRGASGVRGEKTNETIVKQYEAALENIIRTLQDRLTILREEHASFIKVSEKETINERDILNENEAESQRVRQTFRTVSLTLQRVFWGTRDDEVPPLITELDNAAACSEKSRASVKMTLALLDSRLQSFVEQKEWMETHQQALEELMTSLRTLNKRAFERQLSLMNEQSARLPSAP
InterPro domains: - IPR056614: Flagellar attachment zone protein 1, conserved domain (domain) [63-153]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051301 (cell division), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle), GO:0000910 (cytokinesis), GO:1903047 (mitotic cell cycle process), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0000281 (mitotic cytokinesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)
Protein: Kinetoplast polyadenylation/uridylation factor 2 (Q381Z9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MFACRRLLGLTAVGAPTHVRFNHSNNSTESTRDTDKTAASVGDPSKVVSSDSAQKLNLSLRLTDADFGAMVKATKAAMAKERLWRDLTVGSEVDISSESGPNVAIIPKHTVLPKPLGDRSSCFTTVAAEPQGARVDLSGDTRDNVLGNDNPMSSTVTSAVQDRTLTPGVRYGLMDTLRDCLISGDWPKSMRMFESAIQTACNNGKGAETSFTAMRSSDSVINNEMLEGLHRFNATTPVGSFAMNLERYRGILRWSGGHYYLLMKLLLSRHRIEEVERVWDVMKRIGYVEYRMNERTCNQLIALCRTDTKQDIVSPLLHPTKETHNREKEFRTSLVLELENWAEKKHVTLSGRNETTARVARVAHMLRSEGSKDGKDEAVGSIGHGLRVGDFSGLLRRCNSEESTARVLQMMEKLNVPRDGQIYSALIAALRQPHYQLCGSEENLSQSDGTKEAYDAHRKRRLKRARQWYDECPEESRTIDVCNEMLLITRGGSAEDVDYANLLTDIRGTPLTILGSDDTGSDTIAFSKNEGRSRPQIPVPRWRIPPNGRTYEVMVLHCRHHEEWPVVWALYDEMMERNVKGTQRLYQMLLEIVQRHPPCGRDRNTVVLELYEDMKRFGLDVTDIKSTASVVNSWCATRRKRRW
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [172-643]
Interaction partners: - 30S Ribosomal protein S17, putative
- Large ribosomal subunit protein uL3m
- Kinetoplast polyadenylation/uridylation factor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0045333 (cellular respiration), GO:0009060 (aerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Histone H3-like 3 (Q9LR02)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Sequence: MARTKQTARKSHGGKAPRTLLATKAARKSAPTTGGVKKPHRYRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDYKTDLRFQSHAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDVQLARRIRGERA
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [2-136]
- IPR000164: Histone H3/CENP-A (family) [1-136]
- IPR007125: Histone H2A/H2B/H3 (domain) [8-132]
Interaction partners: - Histone H4
- Protein TONSOKU
- Histone H2B.6
- Chromo domain-containing protein LHP1
- Lysine-specific demethylase ELF6
- DNA
- Histone acetyltransferase GCN5
- Histone-lysine N-methyltransferase CLF
- Histone-lysine N-methyltransferase ASHH2
- Chromatin structure-remodeling complex protein SYD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0055046 (microgametogenesis), GO:0007275 (multicellular organism development), GO:0009566 (fertilization), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0009567 (double fertilization forming a zygote and endosperm), GO:0048229 (gametophyte development), GO:0048235 (pollen sperm cell differentiation), GO:0030154 (cell differentiation), GO:0009555 (pollen development), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0000785 (chromatin), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome)