Protein: NAD-dependent protein deacetylase HST2 (Q5A985)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity)
Subcellular location: Cytoplasm. Nucleus
Sequence: MPSLDDILKPVAEAVKNGKKVTFFNGAGISTGAGIPDFRSPDTGLYANLAKLNLPFAEAVFDIDFFKEDPKPFYTLAEELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVEDKYIVEAHGSFASNHCVDCHKEMTTETLKTYMKDKKIPSCQHCEGYVKPDIVFFGEGLPVKFFDLWEDDCEDVEVAIVAGTSLTVFPFASLPGEVNKKCLRVLVNKEKVGTFKHEPRKSDIIALHDCDIVAEKLCTLLGLDDKLNEVYEKEKIKYSKAETKETKMHEIEDKLKEEAHLKEDKHTTKVDKKEKQNDANDKELEQLIDKLKI
InterPro domains: - IPR026591: Sirtuin, catalytic core small domain superfamily (homologous_superfamily) [32-180]
- IPR029035: DHS-like NAD/FAD-binding domain superfamily (homologous_superfamily) [4-277]
- IPR003000: Sirtuin family (family) [26-208]
- IPR026590: Sirtuin family, catalytic core domain (domain) [1-262]
- IPR050134: NAD-dependent sirtuin protein deacylases (family) [8-270]
- IPR017328: Sirtuin, class I (family) [7-321]
Interaction partners: - Glutamine-dependent NAD(+) synthetase
- Nicotinamide-nucleotide adenylyltransferase
- nicotinamidase
- NADH/NAD(+) kinase
- NAD(+) diphosphatase
- Trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
- Purine nucleoside phosphorylase
- Nicotinamide-nucleotide adenylyltransferase
- Histone deacetylase
- Histone deacetylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides), GO:0034979 (NAD-dependent protein deacetylase activity), GO:0017136 (NAD-dependent histone deacetylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:1990700 (nucleolar chromatin organization), GO:0006325 (chromatin organization), GO:0006996 (organelle organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0006997 (nucleus organization), GO:0000183 (rDNA heterochromatin formation), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:0051276 (chromosome organization), GO:0016570 (histone modification), GO:0032200 (telomere organization), GO:0016573 (histone acetylation), GO:0031507 (heterochromatin formation), GO:0006473 (protein acetylation), GO:0018205 (peptidyl-lysine modification), GO:0070828 (heterochromatin organization), GO:0140718 (facultative heterochromatin formation), GO:0018394 (peptidyl-lysine acetylation), GO:0006475 (internal protein amino acid acetylation), GO:0031509 (subtelomeric heterochromatin formation), GO:0140719 (constitutive heterochromatin formation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)