Protein: Cullin-associated NEDD8-dissociated protein 1 (Q5ADW3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable)
Sequence: MHDINFNILKDRAMDVDPDIRFMALEDLRKFLQDESAASTRTTLNQSLENFFPILLNMLNDQNPDVQTQAIKSFEPMVKYLSNETFSKLVKKLFALVQQNSSSTGNVTGMKSFTVSVPNIALRSLFAQSNSRDKSEFVSDKLSNSNYRFDPHLARYIMDYLIPQIVGNPVTIDSIELLIDLVTEIGYVLTQDELLNLSLYLTKVALTETGLIGKKSMVALERVVALVRTEVVIDKLLAQINQSIEPTKLFVIFQLYSVCLKRGIKPNSIDTIYNTITSNLNIEATEEEDDDDLDFDNLVKENSLKDEALTTLIDLVSQHFLPVESKNTVIALIKSYVNYNPLAQDEDFIDDEEDDISFSDDEQEDDGDGENDGSWKLRAKATILTRALLKSFPDTLELLSKEVLPVFSFADSNDQVVSEVIKSSIAIVNSTSPRDSTNVSELFPIIAARMKLAKETQVPLFLKLVESLNRFDNTSLVLEVFKIIKDRKLITSGSFDYLQFYSSTLKFHDNLPPLVIERMSSDFIKNLDDKSFNMITDSIKCLSLLFHQDSLEKLDAIVDLLIYKVENSKQYPSDLVRQSIIALGEAYGRADKQKILNVFKHSIEYEGTSKTTIDVLTQIYSTDIPSEYSYLILKKLSTSIMSSTEATSVASLLLMNKIFERLPSGDYDDTAGNLVQLLAVTNKANYECIFHILIKLVGTVLQETHRAPLLQTIVKLVNEGKIEVADNSFFQFITTACNQIPDLYNFFEDGLNLNSELSAKILAICASQNKLENKIMERREEFQNYYNSNINDSRLAFDILFLGYVGTHIEVKELDVQTLIGLLSNSQLTNDDNISAASTALGLIAQKHIDSAVPIILNAYESSEKTIIRGSLVDSLSIAADACNEDQKRVIWDKVFNFPVEFDHEVITELKKSGELLGKIPVVDELTINTDNLKTTYLILVITKSLLNNLQATKVNNTLLDSLIKSSIEWLNIVNIDIRQIVVGNLLTGLHSKPDTILPILDSIILPKIFDQLQAEDSFKKIITMGPYKYVLDEGLEIRKLCYEFIYSVISLENAVIKKYNINLEKIASKIIEVGLIDTQTDITVLACINLTNYIELHKDSAVELITRDGGNAFTTMINNLKKQLSKKLSAKASTQDSESHQERIKSIIKLSKKFASVVEAAESIELAAAIRVWNEYNNDLKTNFTIYYNSTDGV
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [5-1188]
- IPR011989: Armadillo-like helical (homologous_superfamily) [2-1178]
- IPR039852: Cullin-associated NEDD8-dissociated protein 1/2 (family) [4-1185]
- IPR013932: TATA-binding protein interacting (TIP20) (domain) [1003-1181]
- IPR021133: HEAT, type 2 (repeat) [51-89]
- IPR000357: HEAT repeat (repeat) [51-80]
Interaction partners: - SCF ubiquitin ligase complex subunit
- Cullin
- Cullin
- Cullin
- COP9 signalosome complex subunit 5
- E3 ubiquitin ligase complex SCF subunit
- NEDD8 family protein
- Elongin-C
- NEDD8-conjugating enzyme UBC12
- Defective in cullin neddylation protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)