Protein: DNA-directed RNA polymerase subunit (EC 2.7.7.6) (Q7TSI4)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNNHAPLLYGVLDHRMGTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQEEKQQFLDFLKRPGLTYLQKRGLKKKISDKCRKKSTCHYCGAFNGTVKKCGLLKIIHEKYKTNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLMNPESGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISGAKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVRNGPDVHPGANFIQQRHMQMKRFLKYGNREKMAQELKFGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARVKPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQIFSVILRPSDDNPVRANLRTKGKQYCGKGEDLCVNDSLSPFQMSPSRTVS
InterPro domains: - IPR035697: DNA-directed RNA polymerase III subunit RPC1, N-terminal (domain) [24-636]
- IPR006592: RNA polymerase, N-terminal (domain) [248-553]
- IPR007080: RNA polymerase Rpb1, domain 1 (domain) [13-356]
- IPR044893: RNA polymerase Rpb1, clamp domain superfamily (homologous_superfamily) [1-138]
- IPR015700: DNA-directed RNA polymerase III subunit RPC1 (family) [3-641]
- IPR000722: RNA polymerase, alpha subunit (domain) [358-524]
- IPR042102: RNA polymerase Rpb1, domain 3 superfamily (homologous_superfamily) [533-641]
- IPR007066: RNA polymerase Rpb1, domain 3 (domain) [528-636]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0019222 (regulation of metabolic process), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0043207 (response to external biotic stimulus), GO:0001817 (regulation of cytokine production), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0010628 (positive regulation of gene expression), GO:0032481 (positive regulation of type I interferon production), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0032648 (regulation of interferon-beta production), GO:0032728 (positive regulation of interferon-beta production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0000791 (euchromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)