Protein: nicotinate phosphoribosyltransferase (EC 6.3.4.21) (Q389I2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MKPIIKSILDTDAYKLHMQQAVFHFYPTIHVVYEFQCRSSENKLGDAADAIREQVDLMRHVALTDDEYAYLSTKRYLKKDYLDWLREYRFKPDQVIIDAVPKTRCNGETNITYRELAITIKGPWVETILWEVPLLAIVCEVVHSKRTQHIGAAEAVEHLNAKLDKLFATYVNGELDMFRVTDFGTRRRYSFDVQEAIVRTLQSHPSFGRNFSGTSNYHLAMKLGLPAVGTQAHEWFQAHQQLSPVLRDFQRVALKQWLLEYPQDLHIALTDCISMDGFLGDFDADLAQAYVGLRHDSGNPYVWGRKAIEHYKRFNIDPKLKTLVFSDSLDLERAAKLHCTFAQESNVMCGIGTQLTCSIPGVQPLSIVIKMTECDGKPVAKISDEPEKTTFRDLDYVQLLGRTFNVELQDMIDAGCGRSAVHHPTQVQ
InterPro domains: - IPR040727: Nicotinate phosphoribosyltransferase, N-terminal domain (domain) [9-138]
- IPR041525: Nicotinate/nicotinamide phosphoribosyltransferase (domain) [178-407]
- IPR006406: Nicotinate phosphoribosyltransferase (family) [1-408]
- IPR036068: Nicotinate phosphoribosyltransferase-like, C-terminal (homologous_superfamily) [129-405]
- IPR007229: Nicotinate phosphoribosyltransferase family (family) [1-400]
Interaction partners: - Cytidyltransferase-like domain-containing protein
- DNA-directed RNA polymerase subunit beta
- Tubulin gamma chain
- nicotinamidase
- NAD+ synthase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0072525 (pyridine-containing compound biosynthetic process), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0019363 (pyridine nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0019674 (NAD metabolic process), GO:0009435 (NAD biosynthetic process), GO:0019359 (nicotinamide nucleotide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)