Protein: Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2) (P59266)
Organism: Mus musculus (Mouse)
Function: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18160536, ECO:0000269|PubMed:22106267}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03230}.
Sequence: MEHLERCAWFLRGTLVRATVRRHLPWALVAAMLAGSVVKELSPLPESYLSNKRNVLNVYFVKLAWAWTVCLLLPFIALTNYHLTGKTSLVLRRLSTLLVGTAIWYICTALFSNIEHYTGSCYQSPALEGIRQEHRSKQQCHREGGFWHGFDISGHSFLLTFCALMIVEEMAVLHEVKTDRGHHLHAAITTLVVALGFLTFIWVWMFLCTAVYFHDLTQKVFGTMFGLLGWYGTYGYWYLKSFSPGLPPQSCSLTLKRDTYKK
InterPro domains: - IPR019388: Fat storage-inducing transmembrane protein (family) [1-262]
- IPR046401: Fat storage-inducing transmembrane protein 1/2 (family) [3-259]
Interaction partners: - Seipin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051235 (maintenance of location), GO:0044238 (primary metabolic process), GO:0055088 (lipid homeostasis), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0035383 (thioester metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0010876 (lipid localization), GO:1901360 (organic cyclic compound metabolic process), GO:0006629 (lipid metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0019915 (lipid storage), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0006790 (sulfur compound metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0022604 (regulation of cell morphogenesis), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0044273 (sulfur compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0019439 (aromatic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0140042 (lipid droplet formation), GO:0016042 (lipid catabolic process), GO:0022607 (cellular component assembly), GO:0006637 (acyl-CoA metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0019693 (ribose phosphate metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:1901568 (fatty acid derivative metabolic process), GO:0006996 (organelle organization), GO:0046434 (organophosphate catabolic process), GO:0070925 (organelle assembly), GO:0009261 (ribonucleotide catabolic process), GO:0072523 (purine-containing compound catabolic process), GO:0009117 (nucleotide metabolic process), GO:0035337 (fatty-acyl-CoA metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0007010 (cytoskeleton organization), GO:0034389 (lipid droplet organization), GO:1901292 (nucleoside phosphate catabolic process), GO:0006163 (purine nucleotide metabolic process), GO:1901569 (fatty acid derivative catabolic process), GO:0009154 (purine ribonucleotide catabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009166 (nucleotide catabolic process), GO:0006195 (purine nucleotide catabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process), GO:0034034 (purine nucleoside bisphosphate catabolic process), GO:0140694 (non-membrane-bounded organelle assembly), GO:0033869 (nucleoside bisphosphate catabolic process), GO:0034031 (ribonucleoside bisphosphate catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)