Protein: Probable proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain subunit pts1) (Multicatalytic endopeptidase complex subunit pts1) (Proteasome component pts1) (P30655)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809, ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MNSIVSKYTQSTNNDDPKKIIEEEGFTNRFDVVPVPQSSLYLRNLTDETKNKHCLIKMNHGTTTLAFRYQHGIVVCVDSRASAGPLIASQTVKKVIEINPYLLGTLAGGAADCQFWETVLGMECRLHQLRNKELISVSAASKILSNITYSYKGYGLSMGTMLAGTGKGGTALYYIDSDGTRLKGDLFSVGSGSTFAYGVLDSGYRWDLSKQEALYLAQRSIVAATHRDAYSGGSVNLYHIDENGWVFHGNFDVDSLIWEAKDNENSFAHIPR
InterPro domains: - IPR023333: Proteasome B-type subunit (family) [49-248]
- IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [41-269]
- IPR001353: Proteasome, subunit alpha/beta (family) [58-240]
- IPR016050: Proteasome beta-type subunit, conserved site (conserved_site) [65-112]
- IPR000243: Peptidase T1A, proteasome beta-subunit (family) [69-237]
Interaction partners: - Probable proteasome subunit alpha type-5
- Probable proteasome subunit beta type-3
- Probable proteasome subunit alpha type-3
- Probable proteasome subunit beta type-7
- Probable proteasome subunit beta type-4
- Probable proteasome subunit beta type-2
- Probable proteasome subunit beta type-1
- Probable proteasome subunit alpha type-1
- Probable proteasome subunit alpha type-6
- Probable proteasome subunit alpha type-7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0140535 (intracellular protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0019774 (proteasome core complex, beta-subunit complex), GO:0000502 (proteasome complex), GO:0005839 (proteasome core complex), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)