Protein: MAGUK p55 subfamily member 3 (O88910)
Organism: Mus musculus (Mouse)
Function: Participates in cell spreading through the phosphoinositide- 3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (By similarity). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions
Subcellular location: Apical cell membrane. Cell membrane. Cell junction, adherens junction. Note=Localized in apical villi of Mueller glia cells. Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins. Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (By similarity)
Sequence: MPVLSEDSGLHETLALLTSQLRPDSNHREEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAMALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRFKDSKVFMRALFHYDPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLSYRRTTGTLPSPQNFKKPPYDQPCDKETCDCDGYFKGHYVAGLRRSFRLGCRERLGGSQEAKVPTGAESQVLLTYEEVARYQHQPGERPRLVVLIGSLGAHLHELKQRVVAEDPQQFAVAVPHTTRPRKSHERDGVEYHFVSKQAFEADVHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQERRKTPPVSPDSEDIASSLDEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQEPAASSELS
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [181-311]
- IPR035604: MPP3, SH3 domain (domain) [230-291]
- IPR001478: PDZ domain (domain) [137-218]
- IPR001452: SH3 domain (domain) [226-296]
- IPR014775: L27 domain, C-terminal (domain) [12-120]
- IPR050716: Membrane-associated guanylate kinase (family) [7-560]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [372-565]
- IPR004172: L27 domain (domain) [6-121]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [384-568]
- IPR020590: Guanylate kinase, conserved site (conserved_site) [420-437]
- IPR008144: Guanylate kinase-like domain (domain) [385-568]
- IPR036034: PDZ superfamily (homologous_superfamily) [131-218]
- IPR036892: L27 domain superfamily (homologous_superfamily) [67-118]
Interaction partners: - CD48 antigen
- Signaling lymphocytic activation molecule
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051129 (negative regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0044087 (regulation of cellular component biogenesis), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0032231 (regulation of actin filament bundle assembly), GO:0032232 (negative regulation of actin filament bundle assembly), GO:0110053 (regulation of actin filament organization), GO:0110020 (regulation of actomyosin structure organization), GO:0051493 (regulation of cytoskeleton organization), GO:0051492 (regulation of stress fiber assembly), GO:0051494 (negative regulation of cytoskeleton organization), GO:0051497 (negative regulation of stress fiber assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0032589 (neuron projection membrane), GO:0045211 (postsynaptic membrane), GO:0005794 (Golgi apparatus), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0014069 (postsynaptic density), GO:0043005 (neuron projection), GO:0032590 (dendrite membrane), GO:0098984 (neuron to neuron synapse), GO:0000139 (Golgi membrane), GO:0032279 (asymmetric synapse)