Protein: Two-component response regulator ARR12 (P62598)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the root-meristem size determination through the regulation of cell differentiation. Involved in activating SHY2 during meristem growth and controls PIN expression via activation of SHY2.
Subcellular location: Nucleus.
Sequence: MTVEQNLEALDQFPVGMRVLAVDDDQTCLKILESLLRHCQYHVTTTNQAQKALELLRENKNKFDLVISDVDMPDMDGFKLLELVGLEMDLPVIMLSAHSDPKYVMKGVTHGACDYLLKPVRIEELKNIWQHVVRSRFDKNRGSNNNGDKRDGSGNEGVGNSDQNNGKGNRKRKDQYNEDEDEDRDDNDDSCAQKKQRVVWTVELHKKFVAAVNQLGYEKAMPKKILDLMNVEKLTRENVASHLQKFRLYLKRISGVANQQAIMANSELHFMQMNGLDGFHHRPIPVGSGQYHGGAPAMRSFPPNGILGRLNTPSGIGVRSLSSPPAGMFLQNQTDIGKFHHVSSLPLNHSDGGNILQGLPMPLEFDQLQTNNNKSRNMNSNKSIAGTSMAFPSFSTQQNSLISAPNNNVVVLEGHPQATPPGFPGHQINKRLEHWSNAVSSSTHPPPPAHNSNSINHQFDVSPLPHSRPDPLEWNNVSSSYSIPFCDSANTLSSPALDTTNPRAFCRNTDFDSNTNVQPGVFYGPSTDAMALLSSSNPKEGFVVGQQKLQSGGFMVADAGSLDDIVNSTMKQEQSQGDLSGGDLGYGGFSSLRTCI
InterPro domains: - IPR001005: SANT/Myb domain (domain) [197-246]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [17-133]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [193-252]
- IPR017053: Response regulator B-type, plant (family) [1-596]
- IPR011006: CheY-like superfamily (homologous_superfamily) [16-136]
- IPR017930: Myb domain (domain) [192-251]
- IPR045279: Two-component response regulator ARR-like (family) [17-403]
- IPR006447: Myb domain, plants (domain) [195-248]
Interaction partners: - Histidine-containing phosphotransfer protein 5
- Histidine-containing phosphotransfer protein 3
- Pseudo histidine-containing phosphotransfer protein 6
- Histidine-containing phosphotransfer protein 4
- Histidine kinase 3
- Histidine kinase 4
- Histidine kinase 2
- Ethylene-responsive transcription factor CRF6
- Ethylene-responsive transcription factor CRF2
- Auxin-responsive protein IAA3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0010073 (meristem maintenance), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0098727 (maintenance of cell number), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:1990110 (callus formation), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0019827 (stem cell population maintenance), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0001101 (response to acid chemical), GO:0009414 (response to water deprivation), GO:0009611 (response to wounding), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010075 (regulation of meristem growth), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0080113 (regulation of seed growth), GO:0099402 (plant organ development), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:1905392 (plant organ morphogenesis), GO:0009888 (tissue development), GO:0009755 (hormone-mediated signaling pathway), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010074 (maintenance of meristem identity), GO:0048638 (regulation of developmental growth), GO:1902074 (response to salt), GO:0048364 (root development), GO:0009736 (cytokinin-activated signaling pathway), GO:0071310 (cellular response to organic substance), GO:1901401 (regulation of tetrapyrrole metabolic process), GO:0022622 (root system development), GO:0048367 (shoot system development), GO:0042060 (wound healing), GO:0032870 (cellular response to hormone stimulus), GO:0048507 (meristem development), GO:0010015 (root morphogenesis), GO:0031326 (regulation of cellular biosynthetic process), GO:0031537 (regulation of anthocyanin metabolic process), GO:0009735 (response to cytokinin), GO:0010082 (regulation of root meristem growth), GO:0071368 (cellular response to cytokinin stimulus), GO:1901463 (regulation of tetrapyrrole biosynthetic process), GO:0090056 (regulation of chlorophyll metabolic process), GO:0080022 (primary root development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)