Protein: Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) (O13782)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta(cpp1) subunit is responsible for peptide-binding.
Sequence: MDELSETQVMQNETATAVLPLLNGESQSFNLQKHLKYLTKMLDPLPSPFTVLDASRAWMVYWELSSLAILGKLDSSVCERAISSVRQLKGPSGGFCGGNGQDEHLLSTYASILSICLCDSTDAYSLIERDRLYDWLFSLKNPDGSFRVNNEGESDARSVYAAVCVSSLVGISMDDPLFEGTLQWLCKCQTYEGGLSGVPYAEAHGGYTFCALAAIALLGGLDNLNEIKLSTWLVQRQDPALYGFSGRSNKLVDGCYSWWVGASHVIVASGYGSASHKSLPNLFYNPEKLLGYILQCCQSTSGGLRDKPPKRPDQYHTCYCLLGLSSIAYDYRYHTSDGWSYKPSILHSSLSSLLPAHPIYCVPFGFEERIKSYFLSQESSKF
InterPro domains: - IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [11-375]
- IPR026872: Protein farnesyltransferase subunit beta (family) [32-327]
- IPR045089: Prenyltransferase subunit beta (family) [29-375]
- IPR001330: Prenyltransferase alpha-alpha toroid domain (domain) [29-362]
Interaction partners: - Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
- Probable CAAX prenyl protease 1
- Probable CAAX prenyl protease 2
- Dehydrodolichyl diphosphate synthase complex subunit SPAC4D7.04c-farnesyl diphosphate specific))
- Geranylgeranyl pyrophosphate synthase
- Farnesyl pyrophosphate synthase
- Dehydrodolichyl diphosphate synthase complex subunit nus1
- Decaprenyl-diphosphate synthase subunit 1
- Squalene synthase
- Protein-S-isoprenylcysteine O-methyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0008318 (protein prenyltransferase activity), GO:0004659 (prenyltransferase activity), GO:0004661 (protein geranylgeranyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0051668 (localization within membrane), GO:0070727 (cellular macromolecule localization), GO:0045184 (establishment of protein localization), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0008104 (protein localization), GO:1990778 (protein localization to cell periphery), GO:0061951 (establishment of protein localization to plasma membrane), GO:0072659 (protein localization to plasma membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0043229 (intracellular organelle), GO:1990234 (transferase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)