Protein: Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2) (Q86UC2)
Organism: Homo sapiens (Human)
Function: Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305}.
Sequence: MTVKPAKAASLARNLAKRRRTYLGGAAGRSQEPEVPCAAVLPGKPGDRNCPEFPPPDRTLGCWATDAAPAAGLCGAGSEPSIAPTSCAGNLPSRPPPLLSPLLASRNPCPWHYLHLSGSHNTLAPTCFKAKLHRKRGSQPPDMASALTDRTSRAPSTYTYTSRPRALPCQRSRYRDSLTQPDEEPMHYGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLRPQTPEPVEGRKHVDVQTELYLEEIADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRASQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYDPIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRLCMYEHGEDTHQSPEPEDEPGGPGAMTESLEASEFLEQSMSQTRELLLDGGYLQRTTYDRRSSQERKFMEERELLGQDEETAMRKSLGEEELS
InterPro domains: - IPR009290: Radial spoke 3 (family) [149-558]
Interaction partners: - N-acylneuraminate-9-phosphatase
- Protein phosphatase 1 regulatory subunit 21
- Inhibitor of growth protein 3
- Pre-mRNA-splicing regulator WTAP
- Radial spoke head protein 6 homolog A
- Radial spoke head protein 4 homolog A
- Radial spoke head protein 9 homolog
- Dystrobrevin alpha
- Dystrobrevin beta
- T-cell activation Rho GTPase-activating protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007018 (microtubule-based movement), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0120316 (sperm flagellum assembly), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0016043 (cellular component organization), GO:0007288 (sperm axoneme assembly), GO:0000226 (microtubule cytoskeleton organization), GO:0030317 (flagellated sperm motility), GO:0007283 (spermatogenesis), GO:0030030 (cell projection organization), GO:0003341 (cilium movement), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0060294 (cilium movement involved in cell motility), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0060271 (cilium assembly), GO:0044458 (motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)