Protein: Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Q503E1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Mediates the snRNAs 3' cleavage.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q5TA45}. Cytoplasm {ECO:0000250|UniProtKB:Q5TA45}.
Sequence: MPDIKVTPLGAGQDVGRSCILVSIGGKNIMLDCGMHMGFNDDRRFPDFSYITQNGRLTEFLDCVIISHFHLDHCGALPYMSEMVGYDGPIYMTHPTKAICPILLEDFRKITVDKKGETNFFTSQMIKDCMKKVVPLNLHQTVQVDDELEIKAYYAGHVLGAAMVQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPDILISESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKAPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRSYADNPGPMVVFATPGMLHAGQSLQIFKKWAGNEKNMVIMPGYCVQGTVGHKILNGQKKLEMEGRATLDVKLQVEYMSFSAHADAKGIMQLIRMAEPRNMLLVHGEAKKMEFLKDKIEQEFSISCFMPANGETTTIVTNPSVPVDISLNLLKREMALGGPLPDAKRPRTMHGTLIMKDNSLRLVSPEQALKELGLNEHQLRFTCRVQLHDPHSDTDTLSRIYTHLKSVLKSYSIQHVPDGTVIVESIVIKVTSSAEEPNLKVILLSWSYQDEELGSFLSTLLKKGLPS
InterPro domains: - IPR050698: RNA Processing Metallo-Beta-Lactamase (family) [5-595]
- IPR001279: Metallo-beta-lactamase (domain) [16-233]
- IPR048662: Integrator complex subunit 11, C-terminal domain (domain) [501-592]
- IPR036866: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like (homologous_superfamily) [4-446]
- IPR011108: Zn-dependent metallo-hydrolase, RNA specificity domain (domain) [378-438]
- IPR022712: Beta-Casp domain (domain) [245-363]
- IPR041897: Integrator complex subunit 11, MBL-fold (domain) [6-204]
Interaction partners: - Integrator complex subunit 3
- Integrator complex subunit 5
- Integrator complex subunit 4
- Integrator complex subunit 9
- Integrator complex subunit 1
- Integrator complex subunit 7
- Integrator complex subunit 6
- Integrator complex subunit 2
- Integrator complex subunit 12
- Integrator complex subunit 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004519 (endonuclease activity), GO:0004521 (RNA endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016180 (snRNA processing), GO:0016073 (snRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)