Protein: Epidermal growth factor receptor kinase substrate 8-like protein 3 (EPS8-like protein 3) (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-related protein 3) (Q8TE67)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14565974}.
Sequence: MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMTCKQGSQRVQGPEDALQKLFEMDAQGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEPGLPGTSTLLFQCQEVGAERLKTSLQKALEEELEQRPRLGGLQPGQDRWRGPAMERPLPMEQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDPERDEEVLNHVLRDIELFMGKLEKAQAKTSRKKKFGKKNKDQGGLTQAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDWQLPEPSSQAPLGYQDPVSLRRGSHRLGSTSHFPQEKTHNHDPQPGDPNSRPSSPKPAQPALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPLQPGTPGTQGQSPSRVPMLRLSSRPEEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQMLCPQEAPRILSRLEAVRRMLGISP
InterPro domains: - IPR035462: Eps8, SH3 domain (domain) [455-507]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [443-523]
- IPR033928: Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain (domain) [25-154]
- IPR039801: Epidermal growth factor receptor kinase substrate 8-like (family) [1-514]
- IPR001452: SH3 domain (domain) [450-509]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [514-592]
- IPR041418: SAM domain (domain) [524-583]
- IPR013625: Tensin/EPS8 phosphotyrosine-binding domain (domain) [28-156]
- IPR055093: EPS8, spectrin-like domain (domain) [237-377]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [23-155]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0050839 (cell adhesion molecule binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0008092 (cytoskeletal protein binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0045296 (cadherin binding), GO:0030695 (GTPase regulator activity), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0007264 (small GTPase mediated signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0060491 (regulation of cell projection assembly), GO:0007265 (Ras protein signal transduction), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1900029 (positive regulation of ruffle assembly), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0007266 (Rho protein signal transduction), GO:0046578 (regulation of Ras protein signal transduction), GO:1900027 (regulation of ruffle assembly), GO:0035023 (regulation of Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)