Protein: Transcriptional regulator SKO1 (Q59VR1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Also controls the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress
Subcellular location: Nucleus
Sequence: MSSDHKSKFDLELNPFERSFATKESSSVSLNELAAASNNDAISDVNSVATSGSSINNGSSSNKHNLHIPNISSVNQQQGVNGKLPGITPPLFTPGGRRLPPIGLSPGGTTSRQYSNSTNSGSLQSNTDTLGSNIWGGLPTNQTFQPQPQPQPQPQQQQQPQQQQQTQQPHNFNQFMSGMRKTGLTPNESNIRSGLTPGGLTNFGFGSNLVPGLSTPGALLNGPITPGLSSLLGITQTPSSLLVPTTSSFSQNNQSHLIQPAANTSVGPIPESTALGPHVNIPQANQLQQDQSSQALVGGLPPSQPQPQPQPVIAQQIHTIPENQSIAFDMTQPAVANAHLPESKPDLSETANLQRDLNPTADTTTNTTTATKKRKNDTAGGTNKKAKVAKGKKKEPKSKSKGKNNQEDDQNASNKPEDENVPGKENGNEENHKVEAESKEEHLQNGNETTTTKTNNTGNSSNGTTTTTTTKSKSKKNSNVSEDDKRKNFLERNRVAASKCRQRKKLLIQKMEEELEFYSNGYRELSAEVNELRGAILLLKEKHNIQDEIIDGLLSKPTTVPTNVTSIPSTIPTTLNPT
InterPro domains: - IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [485-541]
- IPR004827: Basic-leucine zipper domain (domain) [481-545]
- IPR051027: Basic leucine zipper (bZIP) transcription factors (family) [139-542]
Interaction partners: - Mitogen-activated protein kinase HOG1
- Transcriptional repressor TUP1
- Transcriptional repressor TUP1
- Transcription regulator
- Amino acid starvation-responsive transcription factor
- Mitogen-activated protein kinase MKC1
- Transcription activator GCR1-like domain-containing protein
- Mid1p
- Transcriptional regulator MNL1
- Transcription factor SKN7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0044010 (single-species biofilm formation), GO:0050794 (regulation of cellular process), GO:0098743 (cell aggregation), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048522 (positive regulation of cellular process), GO:1900190 (regulation of single-species biofilm formation), GO:0009266 (response to temperature stimulus), GO:0098630 (aggregation of unicellular organisms), GO:0010035 (response to inorganic substance), GO:0104004 (cellular response to environmental stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0045785 (positive regulation of cell adhesion), GO:0090609 (single-species submerged biofilm formation), GO:0080090 (regulation of primary metabolic process), GO:0009409 (response to cold), GO:0010038 (response to metal ion), GO:0070417 (cellular response to cold), GO:0010811 (positive regulation of cell-substrate adhesion), GO:1900231 (regulation of single-species biofilm formation on inanimate substrate), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071241 (cellular response to inorganic substance), GO:0010810 (regulation of cell-substrate adhesion), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042710 (biofilm formation), GO:0051252 (regulation of RNA metabolic process), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0010468 (regulation of gene expression), GO:0071467 (cellular response to pH), GO:0071248 (cellular response to metal ion), GO:1900187 (regulation of cell adhesion involved in single-species biofilm formation), GO:0090605 (submerged biofilm formation), GO:0046688 (response to copper ion), GO:0071468 (cellular response to acidic pH), GO:2001141 (regulation of RNA biosynthetic process), GO:1900189 (positive regulation of cell adhesion involved in single-species biofilm formation), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0071280 (cellular response to copper ion), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)