Protein: Ceramide synthase 6 (F1LTP8)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus
Sequence: MAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFIAKPCAVALNIQANGPQIAQPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFSYGVRFLKQTPWLWNTRHCWYNYPYQPLTADLHYYYILELSFYWSLMVSQFTDIKRKDFGIMFLHHLATIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMCDLLFVMFAVVFITTRLGIFPLWVLNTTLFESWEIVGPYPSWWVFNLLLLLLQGLNCFWSYLIVKIACKTVSKGKAGKWNPVHVSKDDRSDIESSSDDEDSEPPGKKLHSSTTTNGTSGTNGYLLTGPCSMDD
InterPro domains: - IPR016439: Sphingosine N-acyltransferase Lag1/Lac1-like (family) [5-373]
- IPR001356: Homeodomain (domain) [80-127]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [79-126]
- IPR006634: TRAM/LAG1/CLN8 homology domain (domain) [130-331]
Interaction partners: - 3-ketodihydrosphingosine reductase
- Alkaline ceramidase
- Neutral ceramidase
- Alkaline ceramidase
- Alkaline ceramidase
- Acid ceramidase
- sphingosine kinase
- Sphingomyelin phosphodiesterase 2
- Ceramide kinase
- Ceramide glucosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0040013 (negative regulation of locomotion), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:2000145 (regulation of cell motility), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0008285 (negative regulation of cell population proliferation), GO:0045595 (regulation of cell differentiation), GO:2000146 (negative regulation of cell motility), GO:0050768 (negative regulation of neurogenesis), GO:0060284 (regulation of cell development), GO:0060251 (regulation of glial cell proliferation), GO:0060253 (negative regulation of glial cell proliferation), GO:0051960 (regulation of nervous system development), GO:0030334 (regulation of cell migration), GO:0010721 (negative regulation of cell development), GO:0030336 (negative regulation of cell migration), GO:1903975 (regulation of glial cell migration), GO:0014014 (negative regulation of gliogenesis), GO:0050767 (regulation of neurogenesis), GO:0014013 (regulation of gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)