Protein: DNA mismatch repair protein spellchecker 1 (P43248)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MQAKATDSRQEPTLNMDTNARRNFIKFHAKLGEKPATTVRFFDHTDRYTVHGSDDCELVAKIVYKSTAFIGALLPDDKKETLQFVSMSKGNFELAVRELLLVRNYRVEVYVKNSSDWEIEYRGSPGNLLQFEDILFSNKEVLVGNSIISLLVKLDGGGQRRVGVASVEQNDCKFQLLEFLDDDFFTELEATVVLLGPKECLLPSIEGEYSAVKTLLDRNGVMITMPKKSGDNDLLQDLNRLLRFAKGQQEDATGLKELQLQLASNALKTAIKYLDLVNDAGNLGHYEIKQLDLNRFVHLDSAAVAALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLESPDTMETLSLDYLKRIPDILMLTKKLMRRKANLQDLFRIYQVILRTPKILKVLHELDNSTIESVICAPFKSFLKDLTGLKQMVEQVVDFEAIERGEYLVKASFDSRLMELQQMMTELYSKMEELQFKCSQELNLDGKNQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQQLSIVEEIIHVAVGYAAPLTLLNNELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLEDVRHPCLELQEHVNFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADDFTLLYQVRSGVMEKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDINVEDLTQLVTQFTKDIEQLDSDYFKSVLATSEA
InterPro domains: - IPR036678: MutS, connector domain superfamily (homologous_superfamily) [125-294]
- IPR000432: DNA mismatch repair protein MutS, C-terminal (domain) [660-850]
- IPR007860: DNA mismatch repair protein MutS, connector domain (domain) [145-287]
- IPR045076: DNA mismatch repair MutS (family) [67-862]
- IPR007696: DNA mismatch repair protein MutS, core (domain) [303-643]
- IPR007861: DNA mismatch repair protein MutS, clamp (domain) [472-566]
- IPR036187: DNA mismatch repair protein MutS, core domain superfamily (homologous_superfamily) [300-612]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [617-913]
- IPR007695: DNA mismatch repair protein MutS-like, N-terminal (domain) [24-131]
- IPR016151: DNA mismatch repair protein MutS, N-terminal (homologous_superfamily) [7-124]
- IPR011184: DNA mismatch repair Msh2-type (family) [6-916]
Interaction partners: - Probable DNA mismatch repair protein Msh6
- Pms2
- Mlh1, isoform A
- Exonuclease 1
- DNA excision repair protein ERCC-1
- DNA repair endonuclease XPF
- Proliferating cell nuclear antigen
- DNA polymerase delta catalytic subunit
- Flap endonuclease 1
- DNA polymerase epsilon catalytic subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0042802 (identical protein binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0000217 (DNA secondary structure binding), GO:0030983 (mismatched DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006298 (mismatch repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032300 (mismatch repair complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)