Protein: Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (B0BL87)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}. Membrane raft {ECO:0000256|ARBA:ARBA00004285}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MRGAALLLLALGLQQAEGRCVFNRTQEYCLCYRLTQESAGSVIQCLAASAVEFQGGDLEKYADFPIEDLDDSTIDMLGSLQIRKIIFSDLLVPEVLLARVLRFFSYTQVQEMVFKSCSFVGRSSWADMAGRALPIVSLRFHNVTAAALAGREQDLSPLSRWLGALQELSVTASRLAVLPCAVGQALRALRSLDLARNSLGDDSLAPAFCQGAFTQLRVLSLRHNNLTSYSGVCGSVRLLGELQHLDLSHNALTAGTPSSPCQWPATLRIFNLSSAGLDHVLAPLPPALEVLDLSSNRLHAVDISLRSLQALFLSRNALPAAPSIRGCPALHTLHLDNNLIAELPRDEALLLEHLQDVAVAGNPFNCTCGGAGAVQALAAVGCLRQGWPQGYVCHAPARYQGVLLRDVPTSVLQCNPAAVLAPVCTGLALLCVAMAGGLLWARGARPRWLCGLGQREDACSGAEHL
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [23-420]
- IPR016337: Monocyte differentiation antigen CD14 (family) [6-383]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [162-351]
- IPR001611: Leucine-rich repeat (repeat) [189-350]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [362-415]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048584 (positive regulation of response to stimulus), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0002253 (activation of immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0031349 (positive regulation of defense response), GO:0002218 (activation of innate immune response), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0002221 (pattern recognition receptor signaling pathway), GO:0002224 (toll-like receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)