Protein: Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS) (P27106)
Organism: Mus musculus (Mouse)
Function: Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P03971}.
Sequence: MQGPHLSPLVLLLATMGAVLQPEAVENLATNTRGLIFLEDELWPPSSPPEPLCLVTVRGEGNTSRASLRVVGGLNSYEYAFLEAVQESRWGPQDLATFGVCSTDSQATLPALQRLGAWLGETGEQQLLVLHLAEVIWEPELLLKFQEPPPGGASRWEQALLVLYPGPGPQVTVTGTGLRGTQNLCPTRDTRYLVLTVDFPAGAWSGSGLILTLQPSREGATLSIDQLQAFLFGSDSRCFTRMTPTLVVLPPAEPSPQPAHGQLDTMPFPQPGLSLEPEALPHSADPFLETLTRLVRALRGPLTQASNTQLALDPGALASFPQGLVNLSDPAALGRLLDWEEPLLLLLSPAAATEREPMPLHGPASAPWAAGLQRRVAVELQAAASELRDLPGLPPTAPPLLARLLALCPNDSRSSGDPLRALLLLKALQGLRAEWHGREGRGRTGRSAGTGTDGPCALRELSVDLRAERSVLIPETYQANNCQGACAWPQSDRNPRYGNHVVLLLKMQARGAALGRLPCCVPTAYAGKLLISLSEERISAHHVPNMVATECGCV
InterPro domains: - IPR006799: Anti-Mullerian hormone, N-terminal (domain) [76-439]
- IPR001839: Transforming growth factor-beta, C-terminal (domain) [438-554]
- IPR021203: Muellerian-inhibiting factor (family) [1-554]
- IPR017948: Transforming growth factor beta, conserved site (conserved_site) [471-486]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [446-554]
Interaction partners: - Anti-Muellerian hormone type-2 receptor
- Bone morphogenetic protein receptor type-1A
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1B
- Chordin
- Noggin
- Neuroblastoma suppressor of tumorigenicity 1
- Bone morphogenetic protein receptor type-2
- Aromatase
- Steroidogenic factor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0005160 (transforming growth factor beta receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060033 (anatomical structure regression), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0050790 (regulation of catalytic activity), GO:0007281 (germ cell development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0048515 (spermatid differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007283 (spermatogenesis), GO:0006793 (phosphorus metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0002088 (lens development in camera-type eye), GO:0009888 (tissue development), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0009994 (oocyte differentiation), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0061458 (reproductive system development), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0051248 (negative regulation of protein metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0050678 (regulation of epithelial cell proliferation), GO:0030855 (epithelial cell differentiation), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0060429 (epithelium development), GO:0048232 (male gamete generation), GO:0051174 (regulation of phosphorus metabolic process), GO:0001654 (eye development), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0006468 (protein phosphorylation), GO:0018193 (peptidyl-amino acid modification), GO:0019220 (regulation of phosphate metabolic process), GO:0150063 (visual system development), GO:0016310 (phosphorylation), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0031401 (positive regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0018108 (peptidyl-tyrosine phosphorylation), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0043010 (camera-type eye development), GO:0042327 (positive regulation of phosphorylation), GO:0018105 (peptidyl-serine phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0018209 (peptidyl-serine modification), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)