Protein: Adhesion G-protein coupled receptor V1 (EC 3.4.-.-) (G-protein coupled receptor 98) (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Q6JAN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor that may have an important role in the development of the sensory nervous system.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8VHN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VHN7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q8VHN7}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q8VHN7}.
Sequence: MPAVLALSGLLLMLLTVSVRSESAELRFQGQTQFVVNESSRAIVRLVVERVGDPINVTALVLLQGDDTGDFEATTAAAFLLSSESSKTIFIAVKDDDIPEADETFVFILRLQSSSNGVTVGTPNTATITILSNDNAFGIISFNSSSLITVEESKGRSQYVPLTLLREKGTYGTVTVNFEIFGGPNPASEDLSPDMGNITFPPGRSVVVFSIMIQDDKLPEDDEIFTVQLTEAAGGALLNPNRSSVQIKISRNDAPIRFSKSTLVVPENIGVISLTVTRGRTEDGLLIGSDDKTVSVAYAIITGNGAASATPLTDFVDLQTERMVVFLPGVHEADLRFSIRDDNIPEIAESFQVVLLEETLLGDAVLVTPSLTLVTIEPNDKPYGVLSISPSPIQPHIINEDLNLIYEGMIIVRNGGTHGAVSVQWNITRNSTDRSPVSADLNPAAGTLRFSEGQMSAVLPLNITQDSLPEEAEAFLLKLIPGSVQGGAEVDEPMEMVFFIQDSDDVYGRFGFHPRENQSIQSQPEGRFLSLSFLREGGTLGEVRLTLTALYIPARPLDPSRARDGVLNGTSVNTVLFSSGQSRAQLILPIRNDAFLQNGAHFRIQLDSVELVNITPPIPSMSPRFAGALNISLIITPDIANGEIGFTSNQTVVALEPEDSNSSLITLQLRRDGTDGQAVVFWSLRPTGENKEDVTKGDISPFTGSVTFLSGQSEAVINLTVLADNIPEINETIILTLDRTNVDNQILKPGFTSREIVILENDDPGGVFEFSPVSKGPWFINEGETVELRVIRAQGQLLNQLIRYTVIPSGTAQFYGATGILEFQPGEREVMVALVAKPDGIPELDETFSVVLSSYSTPASRLGNRREVNITVRKSDDPFGVIEFIQPDLDFTINESKALGCLLSILPPLEKSRGRFGNVSIFWILEPTYSGDVKPVQGEIVFAEGEYQKNLTLSSVADEIPEKTENFTITLLNATGGARLGNILSARLSIRANDDPIYFAEPVGQRVREGGVANFTILRAGLANFVTTVNYRFEYGDTSSEDFIPESNDTMLVFHFGEWMKNISVAVVDDNIPETDEPFYIVLFNATGDAVVYGQITATVVIEANDDANGIFSLDSAQKPGEEGKTNNFYVLRDRGHFGNVTIYWQLFANDTPLEPYQEFVNTSGFITFRTGEKTKPIVLEVISDKLPEFNEFYELRLMNVSGGYPGEGGKLANRDLNASVLIPFNDDPFGVFAIAPDSLEREVAEDVLSVNDMTSVTSLTILRQQGTFGDVRVAWEILSGAFPRGLPPMEDLILMASFPSAVELQPHSRRRHAGTDALFFSGRPGAYGSISAETTLLVPQILANFTLSVWLKPKPNTDGFVVSKGNGNGTVYYGVQVQTNDSHVTIMLHYTTIGSNSTHVARATANTFVEDAWVHVIIAVEDGIIEFYLDGSPIPGGIKSLKGEAIVNDATPIRIGSNPDGEQRFTGLLQDVRLYSSCLNRSQIHELHNQPAKTDLHNVSGYLTYRQEEKEKSFLVEVRDDQEAEGEEVFYLQLVAVQGGARLPMPRPTAILKVMKSDNANGLFSFTGACIPDIAEEGSMISCVVERTRGALDYVYVNYTVTQLDSPADLSNASDFANATGFILFQPGQLSEVLNLLVVNDDLPEVDEHFRVRLVSAKSGDGKPGSTPTSGASIDPEKAVNNVTVKASDHPYGLLQFQTTPVPVGMIRPALEEARVTVQEEAGVVRLLVARAQGLLGRVMVGYRTSPFTAAGSEDYEGFLDFLPGERFKYINVTIIDNSVPELDKVFRVELYNPNGGVDPYFASEGSGSGESETDFFLPSFHYHHANLGAAARIIVTIAASDEAHGVFQFGADSLIVNGTEPEEGRSTVVLQVIRTFGALSNVTVYWEADAASEGELVYRSGNVNFEVGQTVRSIYLLISQDDVPELDKTFKVRLTNASHGRLGKETTATLTVLASDDPYGLFVFSDNTRPVRVAEANALVALTIQRRKGLMGRVRVAYRTLRDTDTVLYSTPGVGRASEGNDFIAVVDSVIFSANQSEVNVTLRVLDDNEPERAESVFLELVSVTLIEGLQPRPVALSPRLGPRNVTIAQVIIEASDDAFGVLQLSSSAVSVPEYYTGPIINVTRIGGIFADVSVKFRAVPLTARVGEDYRVASSDVVLLEGESSKPVPILIINDVVPELEETFRIELLNQTTGGALLGDLTQAIITILPSDDPFGLFVFQAAPITIEEPALTAFEVSVPIVRNAGTMGDVAVQWRATVNGRPATGDLRPVSGEVMFSPGETLKTLKVEVLPDDVPEIEEIIKVELVSATSGGNIGLEKVVDTIVPANDNPHGTVYFEQAVYRVQEPLEGIYIANVTIRRSGGNFGMLEVVYSTLEVDIVSNALKEGRNFLVYYDSRLAGVPSNAIRRPINITTSTNVLNFCAAFCLRERACQAFSFTNTTTPSCFWVTSGVSQLSPSPQTFTYLKNTTATASLFSSQAVAGSDFITMTAQTTTMLDGSGVANLTVPILTDSLPEMDESFIIKILKVSLVNVTATARNLPTIRQPDTALVTIGMNGDAFGIFLLYSINPNATQEGLYLEVREEPKTTVLLVIERRGGSMGQVTVEWKYVGGSATPNADFNGTGETLIFAEGDVKKTLEFIITDDTEPENNETLQIGLVSTEGGSRILPSSDTVTILILANDNAAGVVGFHTASRSRIVREGESVTLLVERTAPAIGNVAVDWRIEGPLVPTTFADTSGTLFFSEGILNNTIVLKLLEDTTPEDREEYRVILSNIQTTGVTKTGIAALSAQGREAVVSVEASDEPFGLLSIAPSSLQVTTDEKNTTIRIYINREFGASGAVNISYETVRGSLQDLRQTEGALAQPGQDFRYVSNSVIMQDGQTSVSIPITIIDDDIPELQEFFLVNITSAVLITTLPTAPKLNTEGLVAEIIINANDGIRGIIGWQNIDYVVNETIGVLTLVAYRDAGTYGNVSLFFYAQNLEAQLGLDFNATPSMIYFVDGERHKFIEVQILDDAVPEGGETFQLILANPSAGLQLGENTTATVMILANDDGHGIISFNNSEHFLLREPTSVSGLGTSVATLYIIRDPPQGTFGTVTVQFTITDVNGSLYTDDLTPSSGFVVLEDGVRYKTLEIWAVLDAEPEMNETFTVTLSNPTGGARLGVSLQTFITVLENQAPLGLFRISPSINRTLDTMTVEEHMGTVFLTVSRSNGLESAVSVEWETRSGTAFGMRGEQPVLAVYQSIRDSFASVWCSVPSGDAALVLRLIKGLTQNQTVLYKWQGVFVPVEFVSIQNPKSCVGFTVNGSSYVAVSHADNTVSLTTNISLFRVQADLNLTLEQTFSVSGFSVKHFSTDLKQYLIASSEIFVWNRGSFFLHQSLELQDIIAAVPFRRGSSNVQHLAVCRNRTSAACFIYQWTDGRFQNPQPLALNTEVKQVESHQMGGDTFLFIVTEGLNPACEVFLWGSQQTVFQQTQSILVPGLFSVHPFTTPSGIFHLLLAGVNGSALYSWRSELRQFAEMLKSASAQEFLYLPVPSINSPKSLILASGKSSSLVYELTSVSNQSDFIPSSGELFFQPGVQELEIAVNVIDDDVPEEEEHFRVSLKNPKGGAEIGFRGQVTFFIPANDDTYGIIGFSQNSLMREVEELQSDNPVSLSIERRRGRFGRLTVHWSAYGSLDDIFPTSGVVTFSESQAVATISLNVLADDIPELAEKVTIVLTKVTTIGIIDPSRGASIDYQRAQANLTIRANGSPYGVIGWHLDSQYFITPEPQKSPSNITLSIVRDQGSSGNVLVYYSTKPALHLLPLNQASGGTDYVAKEATVVMMENATVVLVFLTILPDDIPELAETFFVNITRVEVLGGDTGAAQPSVKRPGLEIAEVTIQENDDPRGVLSFNVSKDVSGAVLAFEVPSPGNVLRLAVMRMAGIFGRLVLYWETQSVTASTEDFTPSSGNITFQDGQAMAYIEITIIDDTIVESTETFMVKLIRVIGGARLGVETSVVVSIPANDSPFGRFGFEELKVSVSEPQFLNDPASVATLTVVRSSGGEGVVHLIWLLQEESRDDLSPRNGTLIFNGTESKKTLVIQALADAVLEGEESFTIQLLSPKNEPVIDPVRGVATVVIRPDVGALGTVGIADSSRNVLIGEPICSYNGTALISLIRGPGIFGEIEIFWNITTAAVSEFEETSGKVVMKDRQSAATIQLKALDDEIPEERRVYQLRLSSLTPGSVINPDRQFASITMAASDLPHGLFSFSQASLRATEEDRAVNVTIVRSMGLFGSVWVSFHTEGRTAISGQDFGQSSGRPLFRPGESSRVIPLVIFDDDLPEGPEEFFLNITLVELLNASSMDFTVREYGLQIDQPPAIGNLSSLMVIIQKNDNAEGILEFDPKYVNNTVEEDVGTLSIPVLRRVGSYGQVTVQFVSKGLTAQPDSDYILLNGSITFQHGQTLSYINVSIVDDTESEFNEIFELQLTGATGGAILGAQLIARITIAKSDSPNGVVRFINQSAITIPNPNSTVRLSLFAERADGLLGDATVMWHIQGPNSNEVLPSMNTDIEPVNGTFSFRDGEGGVRSIDLKILPHGEVEVTEKFIIMLSVISGEMGVDPRAGSVTLTIEKFGDPNGIVQFTEQDLKERIYSEPSDSEGPLKVSVLVTRREGVMGNITVFWEILSDADTSGDFAALRGSVIILAGQRLAEIILTLLPDSVPELEETYTLRLTSVEGGAELDLNRSSTRLKVRANDEPHGVFVMYSQNQSVVVNAADRSRQLIISVNRLAGAFGNASVGYRISFTTPGQSFTEDTITGNILVKDGEREASIRVPVSSQVFFVTGFNFSVELTDVTLIGPLLGSPPRIQLESKLAVVSVPEVAANPVVGFASLALRVLDIESGQCEALVTRTGLYGNITVRWSSGFPPGQTPPGYQPGEILPRSGSIMLAHGQRSELISFTALNNISVVTAHAIYLTSVESESPGGARLRTGYTVAEVEPLGLYQFHPNSQHLVIEEDVQTITLYVQRFYGFRSNRSSVSYRTWPGTAQPDKDYVPVTDGQLLFDSRQTSASIRLSILDDTLTEPDEDFYVNLTSVRVLSTTLPLITAQPGIVQKNSISTVTIRANDVVSGFLSIGPAVKLISEDSVEDSPQQKLQLRVRRTAGLSGVVSAKIRAYAGLKTPLVDASQFHREHKGTWALEGEDFALETQSVTLLEGQNEVEVTVIMLNDQEPEGQEAFFIYLSDAEGGAQIVSVPDELGFTSFAKIIILGSDLQNGIVGFSLSSLSGQVLDEDSVNRTVTLVLQRQENRAFEDVLVFWRVTFSTTDHALVSHGVDLSKELLQTSGTSIRRKGEVLCALKLEVQPDKNPEYEVWFLVEVYKVGEGAAINQTARFANITMLESDDPRGLVYFAQGSRLPVVTLKATSVSLQIYRDASTASSISVEYRMQELPKVESIGPSLVWPAVAGQDFVMSEGTLTFEIGQSSAGLNIDLTPNIGSSNLTPKRFQVVLSDATGGARVHPEFGLANVTLVSDTETQAVWALLDQLHQPLEETIINRVLHALINKVSRDITPEQLMAVLDASSKILSDAEQTPLKDSSRGLTYDLLCAMANPNRTDTQGVSQLSEVAERFAYSLLTDIKCGAEGKRGITILDNCPYFTIAAHHWYPMQINGHTFIGKNTDTFTLPETLLEVPALPADSTAPSACYKVHFTEYSTEHWFLTNKKPSALNGKVFSVSLYGRGSKPLSEGQEVVYRIHTPDRRGKPKPSQSLCLLWNQAAESWLSDGQFCRLVDDTQNYVECACSHLSIYTAYAEIESLASFNEAFYAAGFICISGFALAMVSHLMCARFLMFAAKLLTHMMVACLGTQICFLVSAFRGRMFSEDSCAALGLFFHYFHLSQFGWMLVQAINFWQILVMNDEHTERRYLLYFLLSWGLPALVIIVLVVVLLGGFGWSIHSVYGLVQGDLCFIPNVYAALCTAALVPLICLVGVLVIFIHAYQVTQQWKAYDDIYRGRTNSSEVPMMLYLFALVTLVCVWAGLHMAYRYIWMLILLVIFNIFLGLYVFSVYFVMHNQLFWPGKATYTVEMNGHSSPDSIYQSTGAATVGGGEISKSTQNLISAMEEISADWERASLRPSSQPSSIFKPSPQDEAYITEGGFINTSLVRDEESQEFDDLIFALKTGSGLNVSDNESIHGSHDGGSMANSQIVELRRIPIADTHL
InterPro domains: - IPR038081: CalX-like domain superfamily (homologous_superfamily) [25-5549]
- IPR006558: LamG-like jellyroll fold (domain) [1344-1483]
- IPR003609: PAN/Apple domain (domain) [2386-2470]
- IPR000832: GPCR, family 2, secretin-like (family) [5815-6043]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [1296-1497]
- IPR046338: GAIN domain superfamily (homologous_superfamily) [5644-5794]
- IPR009039: EAR (repeat) [3239-3513]
- IPR003644: Na-Ca exchanger/integrin-beta4 (domain) [31-5239]
- IPR057244: GAIN, subdomain B (domain) [5636-5801]
- IPR017981: GPCR, family 2-like, 7TM (domain) [5800-6051]
- IPR026919: Adhesion G-protein coupled receptor V1 (family) [1-6199]
Interaction partners: - Whirlin
- Usher syndrome 2A
- PDZ domain-containing 7a.
- Whirlin b
- Harmonin
- Si:ch211-57i17.5
- Usher syndrome 1Gb
- Cadherin-related 23.
- Cadherin-related 23
- Clarin 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0035295 (tube development), GO:2000026 (regulation of multicellular organismal development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0035239 (tube morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1901342 (regulation of vasculature development), GO:0045765 (regulation of angiogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0007219 (Notch signaling pathway), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0035904 (aorta development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)