Protein: SKI-like proto-oncogene (D3ZWL1)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MENLQSNFSLVQGSNKKLSGMEDDGSPPVKKMMTDIHANGKTLTQVKKEHLDDYGDASVEPDGEHAKRNCPSLPETLNLNPSLKHTLAQFHLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSWAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPPWYPVIKQEGDHGPQTHSFLHPSYYLYMCDKVVAPNVSLASAASQSKAVTKAETSKSISKQSEKPHDSSKRQKTVSYPDVSLEEQEKMDLKTSRELYSCLDSSVSNNSTSKKKCESTICDLVRDTDKQGSGASSPLVVRDVTCEDDKGKIVEDVMRTYVRQQEKLSSILQKKQQLQMEVEMLSSSKAMKELTEEQQNLQKELESLQNEHAQRMEEFYIEQRDLEKKLEQVMKQKCTCDSNVEKDKEAEYAAQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIVKSSKTAKE
InterPro domains: - IPR037000: Ski-like, DNA-binding domain superfamily (homologous_superfamily) [129-232]
- IPR009061: Putative DNA-binding domain superfamily (homologous_superfamily) [129-232]
- IPR014890: c-SKI SMAD4-binding domain (domain) [258-353]
- IPR023216: Transcription regulator SKI/SnoN (family) [78-673]
- IPR003380: SKI/SNO/DAC domain (domain) [124-231]
- IPR010919: SAND-like domain superfamily (homologous_superfamily) [256-354]
Interaction partners: - Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 3
- Nuclear receptor corepressor 2
- RING-type E3 ubiquitin transferase
- E3 ubiquitin-protein ligase
- Mothers against decapentaplegic homolog 7
- TGFB-induced factor homeobox 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0050793 (regulation of developmental process), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0010033 (response to organic substance), GO:0007283 (spermatogenesis), GO:0034097 (response to cytokine), GO:0050770 (regulation of axonogenesis), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0048232 (male gamete generation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050767 (regulation of neurogenesis), GO:0050772 (positive regulation of axonogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)