wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: O-antigen ligase (EC 2.4.99.26) (Surface polymer:lipid A-core ligase) (P27243)
Organism: Escherichia coli (strain K12)
Function: Adds the O-antigen on the glucose group of LPS.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:19019161, ECO:0000269|PubMed:30047569}; Multi-pass membrane protein {ECO:0000269|PubMed:19019161, ECO:0000269|PubMed:30047569, ECO:0000305|PubMed:15919996}.
Sequence: MLTSFKLHSLKPYTLKSSMILEIITYILCFFSMIIAFVDNTFSIKIYNITAIVCLLSLILRGRQENYNIKNLILPLSIFLIGLLDLIWYSAFKVDNSPFRATYHSYLNTAKIFIFGSFIVFLTLTSQLKSKKESVLYTLYSLSFLIAGYAMYINSIHENDRISFGVGTATGAAYSTMLIGIVSGVAILYTKKNHPFLFLLNSCAVLYVLALTQTRATLLLFPIICVAALIAYYNKSPKKFTSSIVLLIAILASIVIIFNKPIQNRYNEALNDLNSYTNANSVTSLGARLAMYEIGLNIFIKSPFSFRSAESRAESMNLLVAEHNRLRGALEFSNVHLHNEIIEAGSLKGLMGIFSTLFLYFSLFYIAYKKRALGLLILTLGIVGIGLSDVIIWARSIPIIIISAIVLLLVINNRNNTIN
InterPro domains: - IPR007016: O-antigen ligase-related domain (domain) [205-354]
- IPR051533: O-antigen ligase-like (family) [1-407]
Interaction partners: - Lipopolysaccharide heptosyltransferase 2
- Lipopolysaccharide heptosyltransferase 1
- Putative lipopolysaccharide heptosyltransferase 4
- UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
- Putative O-antigen transporter
- Lipid III flippase
- Lipopolysaccharide biosynthesis protein WzxC
- ADP-L-glycero-D-manno-heptose-6-epimerase
- Lipopolysaccharide 1,2-glucosyltransferase
- Lipopolysaccharide glucosyltransferase WaaO
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) (Q97WG4)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
Sequence: MRIIPRTMSTQHPDNAKVPEWAKSEVIEGEDEVKEAFLAYSMYGVHEVMWDAEGKDVDTHVVRKLLSNYPDYFREHILGKDLFLTYRLPNPKVEGADRKVFAETMESIPITYDLAEKFYGNGITIPVFEVILPMTTSSLEIISVARYYEKAVANEDELELYDGVKVKDLVGEIYPKVIEVIPLVEDRDSLQNINNIVEGYYKVIKPKYMRVFLARSDPAMNYGMITAVLSVKIALSELYKLSESLNFEIYPIIGVGSLPFRGHLSPENYEKVLEEYKGVYTYTIQSAFKYDYDYDKVKSAISSINNSRISPARILEKYEEDVLRKITILYTERYQPIIESLANAINDVSVLLPRRRARKLHIGLFGYSRSAGKVSLPRAISFVGSLYSIGIPPELIGISSLSNLDEKEWDIFKQNYVNFKHDLQTAARFLNWESFKLIKDIWKISEDTIAKIKEDIDYAESVIGIKLGGIDYDSRKHILMSSLFLLSFKEKILQESKKYLYEMALIRRSLG
InterPro domains: - IPR007566: Phosphoenolpyruvate carboxylase, archaeal-type (family) [1-511]
- IPR015813: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (homologous_superfamily) [71-456]
Interaction partners: - Malate dehydrogenase
- Phosphoenolpyruvate synthase
- Phosphoenolpyruvate carboxykinase
- Pyruvate kinase
- Enolase
- Citrate synthase
- Formate dehydrogenase Alpha subunit
- Cyclase family protein
- Formate dehydrogenase Alpha subunit
- ATPase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0043169 (cation binding), GO:0016831 (carboxy-lyase activity), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding), GO:0004611 (phosphoenolpyruvate carboxykinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0015977 (carbon fixation), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006107 (oxaloacetate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein R) (Transcobalamin I) (TC I) (TCI) (P20061)
Organism: Homo sapiens (Human)
Function: Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
Subcellular location: Secreted.
Sequence: MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
InterPro domains: - IPR027954: Transcobalamin-like, C-terminal domain (domain) [355-431]
- IPR051588: Eukaryotic Cobalamin Transport (family) [1-433]
- IPR002157: Cobalamin (vitamin B12)-binding protein (family) [9-328]
Interaction partners: - E3 ubiquitin-protein ligase CBL
- Lactotransferrin
- Neutrophil collagenase
- Cobalamin binding intrinsic factor
- Neutrophil gelatinase-associated lipocalin
- Ankyrin repeat and KH domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0019842 (vitamin binding), GO:0046906 (tetrapyrrole binding), GO:0031419 (cobalamin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051180 (vitamin transport), GO:0071705 (nitrogen compound transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005576 (extracellular region), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0005764 (lysosome), GO:0043202 (lysosomal lumen)
Protein: IS605 transposase (TnpA) (O34754)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Not known
Sequence: MRKNHYPLRGYISTNRSKHNLKAHLILVCKYRKKLLQGDLNNFIKSVIDEIATQSNFIIIAMESDIDHLHLMVQYIPRMSISSIISRIKQITTYRVWRDKRFIPLLQKHFWKEKTFWTDGFFVCSIGEANPETIKAYIENQG
InterPro domains: - IPR002686: Transposase IS200-like (domain) [18-141]
- IPR036515: Transposase IS200-like superfamily (homologous_superfamily) [6-142]
Interaction partners: - Urease subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032196 (transposition), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006310 (DNA recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Cyanate hydratase (Cyanase) (EC 4.2.1.104) (Cyanate hydrolase) (Cyanate lyase) (Q9FWK4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
Sequence: MEGGGGERAAGVVRRLMAAKAESRKSFSEIGEEAGLTNVYVAQLLRRQAQLKPETAPALRAAVPGLTDDLVALMMEPPFRSYHPDIVHEPAIYRLNEAVMHFGESIKEIINEEFGDGIMSAIDFYCSVDKVQGADGKDRVVVTFDGKYLPYSEQRSDHMMSRLTRKTS
InterPro domains: - IPR036581: Cyanate lyase, C-terminal domain superfamily (homologous_superfamily) [88-154]
- IPR010982: Lambda repressor-like, DNA-binding domain superfamily (homologous_superfamily) [7-87]
- IPR008076: Cyanate hydratase (family) [1-168]
- IPR003712: Cyanate lyase, C-terminal (domain) [81-154]
Interaction partners: - Signal peptidase complex subunit 1
- Signal peptidase complex catalytic subunit SEC11
- Signal peptidase complex catalytic subunit SEC11
- Os12g0122400 protein
- Os05g0485500 protein
- Hexosyltransferase
- Hexosyltransferase
- Signal peptidase complex subunit 3
- Signal peptidase complex subunit 3
- Hexosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0042802 (identical protein binding), GO:0016840 (carbon-nitrogen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006970 (response to osmotic stress), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0009651 (response to salt stress), GO:0044270 (cellular nitrogen compound catabolic process), GO:1901565 (organonitrogen compound catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Dynactin subunit 2 (Q54N50)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Sequence: MSEGNQPKRVLGLPDVDPSQQDTFETPDPPESISNLADESSELVNESIDRSSLKPAKSHLKFANRKFNNDNEDFSDSIYKKSVPRTGGLLKNQTVFDILPSDESKVETPLQKFQRLQYEVMSFREEMQVIADNGGEVEKDIKGVDLTHQLADLQNQLSHLLENEKLQPILDENKQVIHYSQIQNNSSKKLISEIESFTQQSLSSSTTEQNTQQPSNNNTTTNITSSSSITPNHVTYELFYTGEQSKSQQLQRIQDLEKRLAKLETATGNKTTDSVPITQSILEIKEKLSLLDTTKIDVLQQKMKTVSKEMESLKIQDETSTKALTTNEKKINDIFETMNKWDIVGQQVPAIINRLYTLRSLHEEGISFSNHVSNLEKQQNDITSLLISNSSLMNKMDDSFKSNLLTIKSNIQQLESRIETLQNRQQQQQQ
InterPro domains: - IPR028133: Dynamitin (family) [10-428]
Interaction partners: - Dynactin 150 kDa subunit
- Dynactin subunit 4
- Dynactin subunit 6
- Dynactin subunit 5
- Dynein heavy chain, cytoplasmic
- F-actin-capping protein subunit beta
- Cytoplasmic dynein 1 intermediate chain
- F-actin-capping protein subunit alpha
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynamin-like protein B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0022402 (cell cycle process), GO:0051640 (organelle localization), GO:0007049 (cell cycle), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:1903047 (mitotic cell cycle process), GO:0051653 (spindle localization), GO:0051656 (establishment of organelle localization), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0051294 (establishment of spindle orientation), GO:0006996 (organelle organization), GO:0051293 (establishment of spindle localization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005869 (dynactin complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: Cell wall protein CWP1 (Glycoprotein GP40) (P28319)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the cell wall.
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) as well as protein covalently linked via an alkali-sensitive bond not requiring the GPI-derived structure. Can also be double-anchored to the cell wall through both types of linkages. Incorporated into the birth scar of a daughter cell.
Sequence: MKFSTALSVALFALAKMVIADSEEFGLVSIRSGSDLQYLSVYSDNGTLKLGSGSGSFEATITDDGKLKFDDDKYAVVNEDGSFKEGSESDAATGFSIKDGHLNYKSSSGFYAIKDGSSYIFSSKQSDDATGVAIRPTSKSGSVAADFSPSDSSSSSSASASSASASSSTKHSSSIESVETSTTVETSSASSPTASVISQITDGQIQAPNTVYEQTENAGAKAAVGMGAGALAVAAAYLL
InterPro domains: - IPR000420: Cell wall mannoprotein PIR repeat (repeat) [194-212]
Interaction partners: - ERAD-associated E3 ubiquitin-protein ligase HRD1
- Cell wall protein SED1
- Covalently-linked cell wall protein 14
- Cell wall mannoprotein PIR3
- Congo red hypersensitive protein 1
- Cell wall mannoprotein PIR1
- Glucan 1,3-beta-glucosidase
- Mannan endo-1,6-alpha-mannosidase DFG5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0016043 (cellular component organization), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030312 (external encapsulating structure), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0043231 (intracellular membrane-bounded organelle)
Protein: CG2257 (LD13772p) (LD17992p) (Ubiquitin conjugating enzyme E2H, isoform A (EC 2.3.2.23)) (Ubiquitin conjugating enzyme E2H, isoform B) (Ubiquitin conjugating enzyme E2H, isoform C) (Q7JW03)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSSPSAGKRRMDNDVIKLIESKHEVTILGGLNEFHVKFFGPTETPYEGGVWKVRVYLPDNYPFKSPSIGFVNKIYHPNIDESSGTVCLDVINQAWTALYDLSNIFESFLPQLLTYPNPVDPLNRDAAALYLHEPEEYHRKVADYVQRYATEDALRAAQQERESSDSESSMSDYSEDEARDMEL
InterPro domains: - IPR023313: Ubiquitin-conjugating enzyme, active site (active_site) [75-91]
- IPR016135: Ubiquitin-conjugating enzyme/RWD-like (homologous_superfamily) [6-160]
- IPR000608: Ubiquitin-conjugating (UBC), catalytic core domain (domain) [1-150]
Interaction partners: - WD repeat-containing protein 26 homolog
- FI21269p1
- GH10162p
- Ran-binding proteins 9/10 homolog
- lysozyme
- AT28509p
- LD28546p
- E1 ubiquitin-activating enzyme
- E3 ubiquitin-protein transferase MAEA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0061650 (ubiquitin-like protein conjugating enzyme activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061631 (ubiquitin conjugating enzyme activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Kazal-like domain-containing protein (Q8BM18)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MKTATVPMLLTLAFYLTQDAAGEKGNQDPCMKFQAQMKNGTLTCPKGNNSSQSLNDIIFQSECILCKRALEQGAPTKIMNVKVLSRANRATDPAKLNCESFKQRRKDGDFICPSDTSSVCGTDGKTYRSRCELCAENAKSQNHVDVKSEGECGSSHLETDMCSDFRAYVQDGRLGCTRESDPILGPDGRTHGNRCAMCAELFLKEAKENATRNRESRIRRDAEKELCKEFENQVRNGRLFCTRESDPIRGPDGKMHGNKCALCAEIFMRQFTEEKGKAEKNQKDAEERAKAKMEIQKRCSEFQDRARNGTLFCTRENDPIRGLDGKTHGNLCSMCQAFFKTEAEEKKAEAGSRNRRGSEESETYAKLCDEYRKARKNGQLYCTRENAPIRGPDGKIHGNTCSMCQAFFIQEDKARAKVKREAAKEMCSEFRNQARNGMLMCTRENDPVVGPDGKRHSNKCAMCASVFLLEEEEKKKDDKTEKVDAGKAKKEAVQELCRKYHTQLRNGPLRCTRRNNPIEGLDGKMYKNACFMCWAFFQQEAKKSGAGFRPKVKREVKVDCSEYLALSKRGEIFCTRENDPVRGPDGKTHGNKCAMCKAVFK
InterPro domains: - IPR002350: Kazal domain (domain) [92-601]
- IPR050159: Kazal-type Serine Protease Inhibitor (family) [87-152]
- IPR036058: Kazal domain superfamily (homologous_superfamily) [26-600]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0004857 (enzyme inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0030414 (peptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0009892 (negative regulation of metabolic process), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0045861 (negative regulation of proteolysis), GO:1902571 (regulation of serine-type peptidase activity), GO:0010466 (negative regulation of peptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)