Protein: Voltage-gated inwardly rectifying potassium channel KCNH2 (Q108P2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MPVRRGHVAPQNTFLDTIIRKFEGQNRKFIIANARVENCAIIFCNDGFCGMCGYTRSEVMQKPCTCSFLYGPHTGRPAVAQMAKALLGSEERKVEISLYRKDGVCLPCLVDVVPVKNEDGLVIMFILNFELADQQDRPLDSSPGRDINNKNPIPWLSKARRRRLRLPLPLLHSLSGSKQSLHEDTEKGFMQPMPHMGHESVALDKLLSLPERSALGGSQLLFWEDKAQTESESELRPSEVSPPLPQGFSQSSPRLHNLTSEASPSSCSMAHSRSCESLCGMRPSPSTNDFNWDRKLPVRPSSTGAMHRKASLQNATSDSDLIRLRSSGRGTQISHNLIDMKPDALIAVPTGEIDIIAPCKLIDRTHNVTEKVTQVLSLGADVLPEYKLQAPRIHKWTILHYSPFKAVWDWVILLLVIYTAIFTPYSAAFLLSDEEEEVIQRCGYSCSTLNVVDLIVDIMFVVDIVINFRTTYVNSNDEVVSQPGRIAVHYFKGWFLIDMVAAIPFDLLIYRSEEETTTSTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERSGPSRIGWLNSLGDQLGKPYNSSVRGSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGALMYASIFGNVSAIIQRLNSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRTLLQSCKAFKGSSKGCLRALAMKFKTTHAPPGDTLVHAGDVISALYFISRGSIEILKGDVVVAILGKNDIFGEPINSYARPGKSSADVRALTYCDLHKIHRDDVLEVLEMYPEFSDYFWSNLEITFNLRDTNTKAGSMSSDPDDSDNGGLDHHTRRAKLFFQSKRNSISRDTERTEDRLNRMTFRTQTSGKQHENRQTAHRSSDIFASQSSSDEEEETQRPSVMVDCSQSHINSVSNANRDKDHNSSNSFNALSGAFSGVSNIFSLWGDSSRGHHYQEVPSHSMSFPSSSVPSNTVLHNVTYGQCSEVENRLEMMHRQLYRLEKRMSKDIGAIMQLLQRQMVQVPPAYSSVTSPTEASPIPPKPGQKLVQPVNPLETETPSILSEILDPHDFADSPIKASESLSGAMELQLLDCSSQPPSENPSGAYMGRWSRSVSHHTNTTGDPTAHIHLQQTAIADQAHYSFLDAEPIGTLRQPQAVQSLHLETSECSRRQSLPVKHQVEDDCSMQKRHPSDPGS
InterPro domains: - IPR003938: Potassium channel, voltage-dependent, EAG/ELK/ERG-like (family) [400-832]
- IPR035965: PAS domain superfamily (homologous_superfamily) [38-127]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [669-858]
- IPR050818: Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type (family) [26-1243]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [711-879]
- IPR005821: Ion transport domain (domain) [407-670]
- IPR000014: PAS domain (domain) [37-130]
- IPR003967: Potassium channel, voltage-dependent, ERG (family) [417-812]
- IPR000595: Cyclic nucleotide-binding domain (domain) [744-862]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0060306 (regulation of membrane repolarization), GO:0044057 (regulation of system process), GO:0003013 (circulatory system process), GO:0042391 (regulation of membrane potential), GO:0099623 (regulation of cardiac muscle cell membrane repolarization), GO:0086009 (membrane repolarization), GO:0003015 (heart process), GO:0008015 (blood circulation), GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization), GO:0001508 (action potential), GO:1903522 (regulation of blood circulation), GO:0008016 (regulation of heart contraction), GO:0086001 (cardiac muscle cell action potential), GO:0060047 (heart contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)