Protein: NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (H3BNV2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Sequence: MKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
InterPro domains: - IPR003680: Flavodoxin-like fold (domain) [3-190]
- IPR029039: Flavoprotein-like superfamily (homologous_superfamily) [1-253]
- IPR051545: NAD(P)H dehydrogenase (quinone) (family) [1-209]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0003676 (nucleic acid binding), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0042802 (identical protein binding), GO:0003954 (NADH dehydrogenase activity), GO:0016653 (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor), GO:0003723 (RNA binding), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0098754 (detoxification), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1990748 (cellular detoxification), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0019725 (cellular homeostasis), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0045454 (cell redox homeostasis), GO:0006979 (response to oxidative stress), GO:0072593 (reactive oxygen species metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0009636 (response to toxic substance), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006805 (xenobiotic metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006766 (vitamin metabolic process), GO:0009894 (regulation of catabolic process), GO:0010035 (response to inorganic substance), GO:0099536 (synaptic signaling), GO:1901360 (organic cyclic compound metabolic process), GO:0098869 (cellular oxidant detoxification), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:2001057 (reactive nitrogen species metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0034599 (cellular response to oxidative stress), GO:0042177 (negative regulation of protein catabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0062197 (cellular response to chemical stress), GO:0051248 (negative regulation of protein metabolic process), GO:1901661 (quinone metabolic process), GO:0019430 (removal of superoxide radicals), GO:0006775 (fat-soluble vitamin metabolic process), GO:0000305 (response to oxygen radical), GO:0097237 (cellular response to toxic substance), GO:0006801 (superoxide metabolic process), GO:0099537 (trans-synaptic signaling), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0046209 (nitric oxide metabolic process), GO:0000303 (response to superoxide), GO:0006809 (nitric oxide biosynthetic process), GO:0098916 (anterograde trans-synaptic signaling), GO:0006743 (ubiquinone metabolic process), GO:0042373 (vitamin K metabolic process), GO:0034614 (cellular response to reactive oxygen species), GO:0071450 (cellular response to oxygen radical), GO:0007268 (chemical synaptic transmission), GO:0071451 (cellular response to superoxide), GO:0007271 (synaptic transmission, cholinergic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)