Protein: Glucagon receptor (Q61606)
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Is rapidly internalized after ligand-binding
Sequence: MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNASQCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQEGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRLADSPT
InterPro domains: - IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [15-150]
- IPR003290: GPCR, family 2, glucagon-like peptide-1/glucagon receptor (family) [12-384]
- IPR003291: GPCR, family 2, glucagon receptor (family) [18-484]
- IPR050332: G-protein coupled receptor 2 (family) [13-434]
- IPR017981: GPCR, family 2-like, 7TM (domain) [142-405]
- IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [43-131]
- IPR017983: GPCR, family 2, secretin-like, conserved site (conserved_site) [59-408]
- IPR000832: GPCR, family 2, secretin-like (family) [141-404]
Interaction partners: - Pro-glucagon
- Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
- Guanine nucleotide-binding protein G(q) subunit alpha
- Gastric inhibitory polypeptide
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
- Insulin-2
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- Dipeptidyl peptidase 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0048878 (chemical homeostasis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0033500 (carbohydrate homeostasis), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0042593 (glucose homeostasis), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0032881 (regulation of polysaccharide metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0010628 (positive regulation of gene expression), GO:0006109 (regulation of carbohydrate metabolic process), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:1901701 (cellular response to oxygen-containing compound), GO:0031669 (cellular response to nutrient levels), GO:0010468 (regulation of gene expression), GO:0033762 (response to glucagon), GO:1901653 (cellular response to peptide), GO:0070873 (regulation of glycogen metabolic process), GO:0071375 (cellular response to peptide hormone stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)