Protein: RILP-like protein 2 (Rab-interacting lysosomal-like protein 2) (Q99LE1)
Organism: Mus musculus (Mouse)
Function: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23264467}. Cell projection, cilium {ECO:0000269|PubMed:23264467}.
Sequence: MEDHPVREEEDGEEDEGALAKSPLQLTTDDVYDISYVVGRELMALGSDPRVTRLQFKIVRVMEMLETLVNEGSLAVEELRMERDNLKQEVEGLRKAGVSGAQVNLGPDKMVVDLTDPNRPRFTLQELREVLQERNKLKSQLLLVQEELQCYRSGLLPPRETPGGRREKDAVVAMGNGEKEERTIMKKLFSFRSGKHT
InterPro domains: - IPR021563: Rab interacting lysosomal protein, dimerization domain (domain) [123-189]
- IPR051241: DZIP and RILPL (family) [108-153]
- IPR034743: RH1 domain (domain) [14-96]
- IPR034744: RH2 domain (domain) [119-184]
Interaction partners: - Ras-related protein Rab-8A
- Ras-related protein Rab-10
- Unconventional myosin-Va
- Melanophilin
- Ras-related protein Rab-8B
- Ras-related protein Rab-7L1
- Protein phosphatase 1H
- Ras-related protein Rab-36
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0051050 (positive regulation of transport), GO:0007018 (microtubule-based movement), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0046907 (intracellular transport), GO:0032388 (positive regulation of intracellular transport), GO:0060341 (regulation of cellular localization), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0051222 (positive regulation of protein transport), GO:0010970 (transport along microtubule), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0032386 (regulation of intracellular transport), GO:1904951 (positive regulation of establishment of protein localization), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0070201 (regulation of establishment of protein localization), GO:0016482 (cytosolic transport), GO:0031122 (cytoplasmic microtubule organization), GO:0032880 (regulation of protein localization), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0099111 (microtubule-based transport), GO:0097435 (supramolecular fiber organization), GO:0072384 (organelle transport along microtubule), GO:0032386 (regulation of intracellular transport), GO:0007010 (cytoskeleton organization), GO:0030473 (nuclear migration along microtubule), GO:0034764 (positive regulation of transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)