Protein: Protein transport protein TIP20 (P33891)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8334998}; Peripheral membrane protein {ECO:0000269|PubMed:8334998}.
Sequence: MNGIDDLLNINDRIKQVQNERNELASKLQNLKQSLASNDTEVALSEVIAQDIIEVGASVEGLEQLRAKYGDLQILNKLEKVAVQQTQMQAGVDKLDSFERQLDELAEQPPDQFTLDDVKALHSKLTSVFATVPQINNIDSQYAAYNKLKSKVTGKYNDVIIQRLATNWSNTFDQKLLEAQWDTQKFASTSVGLVKCLRENSTKLYQLSLLYLPLEEETQNGDSERPLSRSNNNQEPVLWNFKSLANNFNVRFTYHFHATSSSSKIETYFQFLNDYLAENLYKCINIFHDDCNGLTKPVIHEQFINYVLQPIRDKVRSTLFQNDLKTLIVLISQILATDKNLLNSFHYHGLGLVSLISDEVWEKWINYEVEMANRQFINITKNPEDFPKSSQNFVKLINKIYDYLEPFYDLDFDLLVRYKLMTCSLIFMNLTSSYLDYILTVDSLNETRTKEQELYQTMAKLQHVNFVYRKIKSLSSNFIFIQLTDIVNSTESKKYNSLFQNVENDYEKAMSTDMQNSIVHRIQKLLKETLRNYFKISTWSTLEMSVDENIGPSSVPSAELVNSINVLRRLINKLDSMDIPLAISLKVKNELLNVIVNYFTESILKLNKFNQNGLNQFLHDFKSLSSILSLPSHATNYKCMSLHELVKILKLKYDPNNQQFLNPEYIKTGNFTSLKEAYSIKYLKDTKIQDALYRIIYGNIL
InterPro domains: - IPR042040: Protein transport protein Tip20, domain E (homologous_superfamily) [635-701]
- IPR042044: EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 (homologous_superfamily) [498-634]
- IPR042042: Protein transport protein Tip20, domain B (homologous_superfamily) [189-323]
- IPR007528: RINT-1/Tip20 (family) [6-701]
- IPR042041: Protein transport protein Tip20, domain A (homologous_superfamily) [1-188]
- IPR042043: Protein transport protein Tip20, domain C (homologous_superfamily) [324-497]
Interaction partners: - Syntaxin UFE1
- Protein transport protein SEC39
- Protein transport protein DSL1
- Protein transport protein SEC20
- Protein transport protein USE1
- Protein transport protein SEC22
- Pleckstrin homology domain protein OPY1
- Coatomer subunit delta
- Protein SLY1
- FKBP12-associated protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0051234 (establishment of localization), GO:0061919 (process utilizing autophagic mechanism), GO:0033036 (macromolecule localization), GO:0009056 (catabolic process), GO:0046907 (intracellular transport), GO:0032258 (cytoplasm to vacuole transport by the Cvt pathway), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0045184 (establishment of protein localization), GO:0006914 (autophagy), GO:0030242 (autophagy of peroxisome), GO:0016236 (macroautophagy), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0048193 (Golgi vesicle transport), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0006623 (protein targeting to vacuole), GO:0072665 (protein localization to vacuole)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099023 (vesicle tethering complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0000938 (GARP complex), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)