Protein: SKP1-like protein 21 (AtSK21) (Q8LF97)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MSEGEMAIIKPEMMKSYIWLETADGSIQQVEQEVAMFCPMICQEVIQKGVGSSKNYAISLPQRVNPAMLSLIFDYCRFHQVPGRSNKERKVYDEKFIRMDTKRLCELTSAADSLQLKPLVDLTSRALARIIEGKTPEEIREIFHLPDDLTEEEKLEPLKNTMDDPRIRLLNRLYAKKRKELKEREKLKSVEVEEHVDERSVDDLLSFINGRDPKVVKTSKSKKKNKKRKEQKNGSSNGTCEALEKDLHNLDSKSQSAEIVDNTASCLGDVSNLPSMEDDIFTPKTEFEDGYIDDEIDPALKELLDREVEDFARRLNSSWVLSIGQERQPVNFSINGNGTSRRLTGPAAGHK
InterPro domains: - IPR001232: S-phase kinase-associated protein 1-like (family) [15-116]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [12-162]
- IPR036296: SKP1-like, dimerisation domain superfamily (homologous_superfamily) [92-159]
- IPR016897: S-phase kinase-associated protein 1 (family) [13-156]
- IPR016072: SKP1 component, dimerisation (domain) [117-155]
Interaction partners: - RING-box protein 1a
- F-box protein 7
- U4/U6 small nuclear ribonucleoprotein PRP4-like protein
- CDT1-like protein b
- RING-box protein 1b
- Cullin-1
- Putative cullin-like protein 2
- Putative cullin-like protein 1
- Cullin-like protein 3
- SKP1-like protein 16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009755 (hormone-mediated signaling pathway), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009725 (response to hormone), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0009867 (jasmonic acid mediated signaling pathway), GO:0071398 (cellular response to fatty acid), GO:0071395 (cellular response to jasmonic acid stimulus), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)