Protein: HECT-type E3 ubiquitin transferase (EC 2.3.2.26) (Q9VTH1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNGGGGGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGML
InterPro domains: - IPR000569: HECT domain (domain) [620-973]
- IPR017134: Ubiquitin-protein ligase E3A (family) [1-973]
- IPR032353: Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (domain) [41-94]
- IPR035983: HECT, E3 ligase catalytic domain (homologous_superfamily) [619-966]
- IPR042556: Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain superfamily (homologous_superfamily) [35-97]
- IPR044611: Ubiquitin-protein ligase E3A/B/C-like (family) [146-972]
Interaction partners: - Fragile X messenger ribonucleoprotein 1 homolog
- 26S proteasome non-ATPase regulatory subunit 4
- Sodium/potassium-transporting ATPase subunit alpha
- Protein cycle
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051050 (positive regulation of transport), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0007276 (gamete generation), GO:0009967 (positive regulation of signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0007281 (germ cell development), GO:0010648 (negative regulation of cell communication), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0007293 (germarium-derived egg chamber formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0007442 (hindgut morphogenesis), GO:0060627 (regulation of vesicle-mediated transport), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:0051130 (positive regulation of cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0035295 (tube development), GO:0048598 (embryonic morphogenesis), GO:0010646 (regulation of cell communication), GO:0010647 (positive regulation of cell communication), GO:0009790 (embryo development), GO:0045807 (positive regulation of endocytosis), GO:1901575 (organic substance catabolic process), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0035239 (tube morphogenesis), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0048619 (embryonic hindgut morphogenesis), GO:0030100 (regulation of endocytosis), GO:0030514 (negative regulation of BMP signaling pathway), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0055123 (digestive system development), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030163 (protein catabolic process), GO:0048477 (oogenesis), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030510 (regulation of BMP signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:0048260 (positive regulation of receptor-mediated endocytosis), GO:0048546 (digestive tract morphogenesis), GO:0008589 (regulation of smoothened signaling pathway), GO:0036211 (protein modification process), GO:0045880 (positive regulation of smoothened signaling pathway), GO:0009057 (macromolecule catabolic process), GO:0043412 (macromolecule modification), GO:0007292 (female gamete generation), GO:0044265 (cellular macromolecule catabolic process), GO:0048232 (male gamete generation), GO:0048565 (digestive tract development), GO:1902531 (regulation of intracellular signal transduction), GO:0009792 (embryo development ending in birth or egg hatching), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0035331 (negative regulation of hippo signaling), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0061525 (hindgut development), GO:0051603 (proteolysis involved in protein catabolic process), GO:0035330 (regulation of hippo signaling), GO:0032446 (protein modification by small protein conjugation), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)