Protein: Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha) (O43184)
Organism: Homo sapiens (Human)
Function: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000305}.
Sequence: MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
InterPro domains: - IPR018358: Disintegrin, conserved site (conserved_site) [464-483]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [214-416]
- IPR001762: Disintegrin domain (domain) [424-510]
- IPR036436: Disintegrin domain superfamily (homologous_superfamily) [424-508]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [209-421]
- IPR006586: ADAM, cysteine-rich domain (domain) [509-652]
- IPR034027: Reprolysin domain, adamalysin-type (domain) [214-414]
- IPR000742: EGF-like domain (domain) [656-688]
- IPR002870: Peptidase M12B, propeptide (domain) [61-126]
Interaction partners: - SH3 and PX domain-containing protein 2A
- TGF-beta receptor type-2
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Syndecan-1
- Growth factor receptor-bound protein 2
- Integrin alpha-7
- Pappalysin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0005102 (signaling receptor binding), GO:0019904 (protein domain specific binding), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0017124 (SH3 domain binding), GO:0008237 (metallopeptidase activity), GO:0004175 (endopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0001775 (cell activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0032879 (regulation of localization), GO:0071704 (organic substance metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0060142 (regulation of syncytium formation by plasma membrane fusion), GO:0033627 (cell adhesion mediated by integrin), GO:0051047 (positive regulation of secretion), GO:0043207 (response to external biotic stimulus), GO:2000145 (regulation of cell motility), GO:0060143 (positive regulation of syncytium formation by plasma membrane fusion), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0010632 (regulation of epithelial cell migration), GO:0010035 (response to inorganic substance), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0031589 (cell-substrate adhesion), GO:1902074 (response to salt), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:1903530 (regulation of secretion by cell), GO:0044093 (positive regulation of molecular function), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0098609 (cell-cell adhesion), GO:0006979 (response to oxidative stress), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:2000147 (positive regulation of cell motility), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0002274 (myeloid leukocyte activation), GO:0080090 (regulation of primary metabolic process), GO:0051222 (positive regulation of protein transport), GO:1903532 (positive regulation of secretion by cell), GO:0051246 (regulation of protein metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0002237 (response to molecule of bacterial origin), GO:0033630 (positive regulation of cell adhesion mediated by integrin), GO:0043588 (skin development), GO:0030334 (regulation of cell migration), GO:0007160 (cell-matrix adhesion), GO:0051592 (response to calcium ion), GO:0051223 (regulation of protein transport), GO:0008544 (epidermis development), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:0050708 (regulation of protein secretion), GO:1901701 (cellular response to oxygen-containing compound), GO:0010467 (gene expression), GO:0010038 (response to metal ion), GO:0071559 (response to transforming growth factor beta), GO:0034097 (response to cytokine), GO:0007229 (integrin-mediated signaling pathway), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0006508 (proteolysis), GO:0071310 (cellular response to organic substance), GO:0051604 (protein maturation), GO:0032880 (regulation of protein localization), GO:0042982 (amyloid precursor protein metabolic process), GO:0050714 (positive regulation of protein secretion), GO:0030855 (epithelial cell differentiation), GO:0033993 (response to lipid), GO:0010634 (positive regulation of epithelial cell migration), GO:0051247 (positive regulation of protein metabolic process), GO:0051046 (regulation of secretion), GO:0033628 (regulation of cell adhesion mediated by integrin), GO:0042542 (response to hydrogen peroxide), GO:0051338 (regulation of transferase activity), GO:0060429 (epithelium development), GO:0000302 (response to reactive oxygen species), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0071222 (cellular response to lipopolysaccharide), GO:0045937 (positive regulation of phosphate metabolic process), GO:0010042 (response to manganese ion), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0043549 (regulation of kinase activity), GO:0030216 (keratinocyte differentiation), GO:0043410 (positive regulation of MAPK cascade), GO:0031401 (positive regulation of protein modification process), GO:0043408 (regulation of MAPK cascade), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0071396 (cellular response to lipid), GO:0034612 (response to tumor necrosis factor), GO:0009913 (epidermal cell differentiation), GO:0042987 (amyloid precursor protein catabolic process), GO:0033619 (membrane protein proteolysis), GO:0016485 (protein processing), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0043406 (positive regulation of MAP kinase activity), GO:0001934 (positive regulation of protein phosphorylation), GO:0042325 (regulation of phosphorylation), GO:0031293 (membrane protein intracellular domain proteolysis), GO:0033674 (positive regulation of kinase activity), GO:0007179 (transforming growth factor beta receptor signaling pathway), GO:0006509 (membrane protein ectodomain proteolysis), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0045860 (positive regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0005634 (nucleus)