Protein: Histocompatibility 2, M region locus 2 (MHC class Ib antigen) (Q6W9L1)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: METSAFFTLLFTLYLLLGASLALAQTFKGSHSLRYFDIAVSRPGLEETHYMTVGYVDDTEFVHFDNEAENPRFEPRVPWMEQMGQKYWDDQTRIAKAAEQQIRVYFQKLRDYYNQSQNSSHTIQRMTGCYIGPDGHLLHAYRQFGYDGQDYLTLNEDLSTWTAADAAAEITRREWEATNVAEFWRVYLEGPCMVWLFKYLTVGNETLLRTEPPKAYVTHHPRPEGDVTLRCWALGFYPSDIIMIWQRDGEDQTQDMDVIETRPAGDGTFQKWVAVVVPSGKEQNYTCHVAHEGLPEPLTLRWSRPPQSFIFIIIVAVGLVLLGASVATLVMWKKSSGGERGSL
InterPro domains: - IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [30-209]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [212-303]
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [22-335]
- IPR011161: MHC class I-like antigen recognition-like (domain) [29-207]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [210-312]
- IPR007110: Immunoglobulin-like domain (domain) [213-301]
- IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [28-209]
- IPR001039: MHC class I alpha chain, alpha1 alpha2 domains (domain) [87-203]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [285-291]
- IPR003597: Immunoglobulin C1-set (domain) [224-297]
Interaction partners: - H2-O alpha
- Histocompatibility 2, class II antigen E beta2
- H-2 class II histocompatibility antigen, A-B alpha chain
- Beta-2-microglobulin
- Class II histocompatibility antigen, M alpha chain
- H-2 class II histocompatibility antigen, E-B beta chain
- H-2 class II histocompatibility antigen gamma chain
- Class II histocompatibility antigen, M beta 1 chain
- H2-M beta 2
- Tapasin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003823 (antigen binding), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0042605 (peptide antigen binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0001775 (cell activation), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0019882 (antigen processing and presentation), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0019884 (antigen processing and presentation of exogenous antigen), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002366 (leukocyte activation involved in immune response), GO:0080134 (regulation of response to stress), GO:0031343 (positive regulation of cell killing), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0032101 (regulation of response to external stimulus), GO:0034641 (cellular nitrogen compound metabolic process), GO:0001817 (regulation of cytokine production), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0046649 (lymphocyte activation), GO:0098542 (defense response to other organism), GO:0019883 (antigen processing and presentation of endogenous antigen), GO:0031341 (regulation of cell killing), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0031325 (positive regulation of cellular metabolic process), GO:0002697 (regulation of immune effector process), GO:2001057 (reactive nitrogen species metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009617 (response to bacterium), GO:0002263 (cell activation involved in immune response), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0031323 (regulation of cellular metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0031347 (regulation of defense response), GO:1904407 (positive regulation of nitric oxide metabolic process), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0002478 (antigen processing and presentation of exogenous peptide antigen), GO:0002703 (regulation of leukocyte mediated immunity), GO:0032649 (regulation of type II interferon production), GO:0002237 (response to molecule of bacterial origin), GO:0010628 (positive regulation of gene expression), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0032729 (positive regulation of type II interferon production), GO:0010468 (regulation of gene expression), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0080164 (regulation of nitric oxide metabolic process), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0042742 (defense response to bacterium), GO:0031326 (regulation of cellular biosynthetic process), GO:0002483 (antigen processing and presentation of endogenous peptide antigen), GO:0042110 (T cell activation), GO:0002821 (positive regulation of adaptive immune response), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0002285 (lymphocyte activation involved in immune response), GO:0046209 (nitric oxide metabolic process), GO:0002819 (regulation of adaptive immune response), GO:0002286 (T cell activation involved in immune response), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity), GO:0002717 (positive regulation of natural killer cell mediated immunity), GO:0001914 (regulation of T cell mediated cytotoxicity), GO:0045429 (positive regulation of nitric oxide biosynthetic process), GO:0006809 (nitric oxide biosynthetic process), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0045428 (regulation of nitric oxide biosynthetic process), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0046631 (alpha-beta T cell activation), GO:0001916 (positive regulation of T cell mediated cytotoxicity), GO:0002715 (regulation of natural killer cell mediated immunity), GO:0002711 (positive regulation of T cell mediated immunity), GO:0002709 (regulation of T cell mediated immunity), GO:0002287 (alpha-beta T cell activation involved in immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)