Protein: Tropomyosin-1, isoforms 9A/A/B (Cytoskeletal tropomyosin) (Tropomyosin II) (P06754)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Subcellular location: [Isoform 9A]: Cytoplasm, cytoskeleton.
Sequence: MDAIKKKMQAMKVDKDGALERALVCEQEARDANTRAEKAEEEARQLQKKIQTVENELDQTQEALTLVTGKLEEKNKALQNKKKTTKMTTSIPQGTLLDVLKKKMRQTKEEMEKYKDECEEFHKRLQLEVVRREEAESEVAALNRRIQLLEEDLERSEERLGSATAKLSEASQAADESERARKILENRALADEERMDALENQLKEARFLAEEADKKYDEVARKLAMVEADLERAEERAEQGENKIVELEEELRVVGNNLKSLEVSEEKANQREEEYKNQIKTLNTRLKEAEARAEFAERSVQKLQKEVDRLEDDLVLEKERYKDIGDDLDTAFVELILKE
InterPro domains: - IPR000533: Tropomyosin (family) [1-335]
Interaction partners: - KxDL motif-containing protein CG10681
- Tropomyosin-2
- GEO12017p1
- Degringolade, isoform A
- Kinesin heavy chain
- Calmodulin-related protein 97A
- Yuri gagarin, isoform B
- Dynamin
- LIM and SH3 domain protein Lasp
- Cortactin, isoform A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0003008 (system process), GO:0007610 (behavior), GO:0032989 (cellular component morphogenesis), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0051128 (regulation of cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0050807 (regulation of synapse organization), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:1901888 (regulation of cell junction assembly), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0030182 (neuron differentiation), GO:0097435 (supramolecular fiber organization), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0051963 (regulation of synapse assembly), GO:0031175 (neuron projection development), GO:0051017 (actin filament bundle assembly), GO:0048699 (generation of neurons), GO:0061572 (actin filament bundle organization), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0055002 (striated muscle cell development), GO:1904396 (regulation of neuromuscular junction development), GO:0140694 (non-membrane-bounded organelle assembly), GO:0048812 (neuron projection morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0032432 (actin filament bundle), GO:0070864 (sperm individualization complex), GO:0071944 (cell periphery), GO:0042641 (actomyosin), GO:0099080 (supramolecular complex), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043292 (contractile fiber), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0016528 (sarcoplasm), GO:0045495 (pole plasm), GO:0043228 (non-membrane-bounded organelle), GO:0097517 (contractile actin filament bundle), GO:0001725 (stress fiber), GO:0099081 (supramolecular polymer), GO:0043233 (organelle lumen), GO:0097517 (contractile actin filament bundle), GO:0001725 (stress fiber), GO:0043227 (membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0043186 (P granule), GO:0060293 (germ plasm), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0030864 (cortical actin cytoskeleton), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)