Protein: Nuclear hormone receptor FTZ-F1 (FTZ-F1 alpha) (Nuclear receptor subfamily 5 group A member 3) (P33244)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts as a cofactor to fushi tarazu (ftz). Facilitates the binding of ftz to DNA. Binds the sequence element 5'-YCYYGGYCR-3' in the zebra element of ftz. Probably also functions as a receptor for a yet unknown ligand.
Subcellular location: Nucleus.
Sequence: MDTFNVPMLAESSNTNYATEATSNHHHLQHQHQQQHSHQQQQQQQLLMPHHHKDQMLAAGSSPMLPFYSHLQLQQKDATATIGPAAAAAAVEAATTSANADNFSSLQTIDASQLDGGISLSGLCDRFFVASPNPHSNSNMTLMGTATAATTTTTNNNNNNNTNNNNNNNVEAKTVRPSNGNSVIIESVTMPSFANILFPTHRSANECIDPALLQKNPQNPNGNNSSIIVPPVEYHQLKPLEVNSSTSVSTSNFLSSTTAQLLDFEVQVGKDDGHISTTTTTGPGSGSASGSGSGSGSGSGSIARTIGTATPTTTTSMSNTANPTRSSLHSIEELAASSCAPRAASPNSNHTSSASTTPQQQQQQQHHMQSGNHSGSNLSSDDESMSEDEFGLEIDDNGGYQDTTSSHSQQSGGGGGGGGGNLLNGSSGGSSAGGGYMLLPQAASSSGNNGNPNAGHMSSGSVGNGSGGAGNGGAGGNSGPGNPMGGTSATPGHGGEVIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRNSMGPDIKPTPISPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNASTGGVIATPMNAGTGGSGGGGLNGPSSVGNGNSSNGSSNGNNNSSTGNGTSGGGGGNNAGGGGGGTNSNDGLHRNGGNGNSSCHEAGIGSLQNTADSKLCFDSGTHPSSTADALIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPSVRGIVNRKTVSEGHDNVQAALLDYTLTCYPSVNDKFRGLVNILPEIHAMAVRGEDHLYTKHCAGSAPTQTLLMEMLHAKRKG
InterPro domains: - IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [554-1027]
- IPR016355: Nuclear hormone receptor family 5-like (family) [337-1026]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [792-1024]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [505-580]
- IPR001723: Nuclear hormone receptor (family) [569-941]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [501-609]
Interaction partners: - Segmentation protein fushi tarazu
- Armadillo segment polarity protein
- Taiman, isoform G
- Ecdysone receptor
- Uridine-cytidine kinase
- Uridine kinase
- FI18188p1
- Pre-mRNA-splicing factor RBM22
- Multiprotein bridging factor 1, isoform E
- Nuclear hormone receptor FTZ-F1 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0004879 (nuclear receptor activity), GO:0098531 (ligand-activated transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0042303 (molting cycle), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0009791 (post-embryonic development), GO:0048522 (positive regulation of cellular process), GO:0007591 (molting cycle, chitin-based cuticle), GO:0002165 (instar larval or pupal development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0002164 (larval development), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0040003 (chitin-based cuticle development), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)