Protein: Dyslexia-associated protein KIAA0319 homolog (Q5SZV5)
Organism: Mus musculus (Mouse)
Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5VV43}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q5VV43}. Early endosome membrane {ECO:0000250|UniProtKB:Q5VV43}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q5VV43}.
Sequence: MVSPPGVLSSLLLLAAMAGGSSQQCSEGRTYSDAIISPNPETIRIMRVSQTFSVGDCTAACCDLLTCDLAWWFEGSCYLVKCMRSENCEPRTTGPIRSYLTFVRRPVQRPGQLLDYGDMMLSRGSPSGAWGDSLEDLRKDLPFLGKDGGPEETTEYSDEYKDLERGLLQPSNQQDPRGSAEYPDWSLLPSNEGGFNATATGDNSAASMEKLQDPTPHPLDQEQLQALNESTWSPTPGHSSISSVWPSSASPLPTEEGLEGEETLQLQEQPSNSSGKEVPMPSHNPSPASLESSPATTEKNSNFTVTPRSRKHSTPTFPTSTVLTGLTPPPWPLSPTASRTVKALAVSAGDNLVLTLPDREAELKASVEPAPPADTTYSYEWSLMSHPVDFQGKIKQENKPTLHLSQLSVGLYAFRVAVSSENAFGEGYVNVTVMPAARVNQPPVAVVSPQTQELSVPLTSALIDGSQSTDDTEIVSYHWEEVDGPFLGEEFPADTPILRLSNLVPGNYTFRLTITDSDGATNSTTASLVIRDAVDYPPVANAGPNQTITLPQNTIILNGNQSSDDHQIVLYEWFAGPGGESKEMVMQGAQTPYLHLSELQEGEYTFQLMVTDSSGQQSTALVAVTVQAENNQAPVAVAGPDKELVFPVQSATLDGSRSSDDHGIVCYHWEHIRGPSAVEMENVDKAIATVTGLQVGIYHFRLTVRDQQGLSSTSTLTVAVKKENNSPPRAQAGGRHVLILPNNSITLDGSRSTDDRGIVSYLWIRDGQSPAAGDVIGGSDHRAALQLTNLVEGVYTFHLLVTDSQGASDSDAATVEVLPDPKKDGLVELILQVGVEQLTEQQKETLVRQLAVLLNVLDSDVKVLKIQAHTDVSTVIVFYVQSGSPFKVLRAAAVARNLHKRLSKEKEAFLLFKVLRVDTAGCLLKCSGHGHCDPITKRCICSQLWMENLIQRYMWDGESNCEWSVFYVAALALTLTLLTGAVSWLCICCCRRRKRTKIRKKTKYTILDSMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFESDQDTLFSRERMERGVLKGSLNGCARNGVSFGYYSKDR
InterPro domains: - IPR056502: KIAA0319-like, C-terminal domain (domain) [826-919]
- IPR011106: Seven cysteines, N-terminal (domain) [20-102]
- IPR029865: Dyslexia-associated protein KIAA0319-like (family) [12-1079]
- IPR022409: PKD/Chitinase domain (domain) [345-820]
- IPR000601: PKD domain (domain) [466-633]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [341-824]
- IPR013980: MANSC domain (domain) [13-106]
- IPR035986: PKD domain superfamily (homologous_superfamily) [440-821]
Interaction partners: - Doublecortin domain-containing protein 2
- Dynein axonemal assembly factor 4
- Tyrosyl-DNA phosphodiesterase 2
- Acyl-coenzyme A thioesterase 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0009653 (anatomical structure morphogenesis), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0001666 (response to hypoxia), GO:0051129 (negative regulation of cellular component organization), GO:0009611 (response to wounding), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0001558 (regulation of cell growth), GO:0048513 (animal organ development), GO:0080135 (regulation of cellular response to stress), GO:0032101 (regulation of response to external stimulus), GO:0000902 (cell morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0050878 (regulation of body fluid levels), GO:0060322 (head development), GO:0045596 (negative regulation of cell differentiation), GO:0030900 (forebrain development), GO:0048640 (negative regulation of developmental growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0032102 (negative regulation of response to external stimulus), GO:0048681 (negative regulation of axon regeneration), GO:0032535 (regulation of cellular component size), GO:0030030 (cell projection organization), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0032990 (cell part morphogenesis), GO:0060284 (regulation of cell development), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0051960 (regulation of nervous system development), GO:0048666 (neuron development), GO:0061387 (regulation of extent of cell growth), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:0050768 (negative regulation of neurogenesis), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030516 (regulation of axon extension), GO:0007417 (central nervous system development), GO:0030517 (negative regulation of axon extension), GO:0031345 (negative regulation of cell projection organization), GO:0048858 (cell projection morphogenesis), GO:0010721 (negative regulation of cell development), GO:0030182 (neuron differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:0050771 (negative regulation of axonogenesis), GO:0031175 (neuron projection development), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0048812 (neuron projection morphogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005802 (trans-Golgi network)