Protein: 26S proteasome regulatory subunit 4 homolog (Tat-binding homolog 5) (P40327)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Has ATPase activity.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Sequence: MGQGVSSGQDKKKKKGSNQKPKYEPPVQSKFGRKKRKGGPATAEKLPNIYPSTRCKLKLLRMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNPLSIGTLEEIIDDDHAIVTSPTMPDYYVSILSFVDKELLEPGCSVLLHHKTMSIVGVLQDDADPMVSVMKMDKSPTESYSDIGGLESQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDLSTKKKILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRERRMQVTAEDFKQAKERVMKNKVEENLEGLYL
InterPro domains: - IPR003960: ATPase, AAA-type, conserved site (conserved_site) [322-340]
- IPR003593: AAA+ ATPase domain (domain) [215-354]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [374-417]
- IPR003959: ATPase, AAA-type, core (domain) [219-351]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [172-431]
- IPR050221: 26S Proteasome Regulatory ATPase (family) [53-428]
- IPR032501: Proteasomal ATPase, second OB domain (domain) [106-160]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [104-171]
Interaction partners: - 26S proteasome regulatory subunit RPN9
- Probable 26S proteasome regulatory subunit p28
- 26S proteasome regulatory subunit RPN13
- Proteasome subunit alpha type-5
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit RPN2
- 26S proteasome regulatory subunit 7 homolog
- Proteasome subunit alpha type-1
- Probable proteasome subunit alpha type-7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0044093 (positive regulation of molecular function), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044092 (negative regulation of molecular function), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0044087 (regulation of cellular component biogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0043254 (regulation of protein-containing complex assembly), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0019439 (aromatic compound catabolic process), GO:0030163 (protein catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006325 (chromatin organization), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0009057 (macromolecule catabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006259 (DNA metabolic process), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0016070 (RNA metabolic process), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006401 (RNA catabolic process), GO:0006281 (DNA repair), GO:0051603 (proteolysis involved in protein catabolic process), GO:0006338 (chromatin remodeling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0010498 (proteasomal protein catabolic process), GO:0045898 (regulation of RNA polymerase II transcription preinitiation complex assembly), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0032784 (regulation of DNA-templated transcription elongation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0043248 (proteasome assembly), GO:0006289 (nucleotide-excision repair), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:2000142 (regulation of DNA-templated transcription initiation), GO:0034661 (ncRNA catabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0019941 (modification-dependent protein catabolic process), GO:0034660 (ncRNA metabolic process), GO:0034243 (regulation of transcription elongation by RNA polymerase II), GO:0032786 (positive regulation of DNA-templated transcription, elongation), GO:2000144 (positive regulation of DNA-templated transcription initiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0060260 (regulation of transcription initiation by RNA polymerase II), GO:0016075 (rRNA catabolic process), GO:0016072 (rRNA metabolic process), GO:0060261 (positive regulation of transcription initiation by RNA polymerase II), GO:0032968 (positive regulation of transcription elongation by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0022624 (proteasome accessory complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0008540 (proteasome regulatory particle, base subcomplex), GO:0005838 (proteasome regulatory particle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:1905368 (peptidase complex), GO:0034515 (proteasome storage granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)