Protein: HFE protein (Homeostatic iron regulator) (Q6B0J5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Sequence: MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQEGSESSSLPGKVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTLVIGVISGIAVFVVILFIGILFIILRKRQGSRGAMGHYVLAERE
InterPro domains: - IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [27-202]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [210-296]
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [19-322]
- IPR011161: MHC class I-like antigen recognition-like (domain) [27-200]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [206-292]
- IPR007110: Immunoglobulin-like domain (domain) [188-283]
- IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [23-204]
- IPR001039: MHC class I alpha chain, alpha1 alpha2 domains (domain) [83-198]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [277-283]
- IPR003597: Immunoglobulin C1-set (domain) [211-289]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0002683 (negative regulation of immune system process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0048878 (chemical homeostasis), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0050777 (negative regulation of immune response), GO:0002695 (negative regulation of leukocyte activation), GO:0051047 (positive regulation of secretion), GO:0044085 (cellular component biogenesis), GO:0010469 (regulation of signaling receptor activity), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0002694 (regulation of leukocyte activation), GO:0060627 (regulation of vesicle-mediated transport), GO:0051098 (regulation of binding), GO:0001817 (regulation of cytokine production), GO:0009894 (regulation of catabolic process), GO:0055082 (intracellular chemical homeostasis), GO:0010035 (response to inorganic substance), GO:0050866 (negative regulation of cell activation), GO:0002701 (negative regulation of production of molecular mediator of immune response), GO:0007162 (negative regulation of cell adhesion), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0002698 (negative regulation of immune effector process), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050801 (monoatomic ion homeostasis), GO:0009967 (positive regulation of signal transduction), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1903530 (regulation of secretion by cell), GO:0002577 (regulation of antigen processing and presentation), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046887 (positive regulation of hormone secretion), GO:0044092 (negative regulation of molecular function), GO:0060341 (regulation of cellular localization), GO:0098771 (inorganic ion homeostasis), GO:0051130 (positive regulation of cellular component organization), GO:0010817 (regulation of hormone levels), GO:0031324 (negative regulation of cellular metabolic process), GO:0046883 (regulation of hormone secretion), GO:0050776 (regulation of immune response), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0001818 (negative regulation of cytokine production), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045807 (positive regulation of endocytosis), GO:1903532 (positive regulation of secretion by cell), GO:2000272 (negative regulation of signaling receptor activity), GO:0051100 (negative regulation of binding), GO:0002703 (regulation of leukocyte mediated immunity), GO:0051246 (regulation of protein metabolic process), GO:0022407 (regulation of cell-cell adhesion), GO:0002704 (negative regulation of leukocyte mediated immunity), GO:0031330 (negative regulation of cellular catabolic process), GO:0002793 (positive regulation of peptide secretion), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0048260 (positive regulation of receptor-mediated endocytosis), GO:0043393 (regulation of protein binding), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:0055072 (iron ion homeostasis), GO:0022607 (cellular component assembly), GO:0090276 (regulation of peptide hormone secretion), GO:0071772 (response to BMP), GO:0043933 (protein-containing complex organization), GO:0022408 (negative regulation of cell-cell adhesion), GO:0010629 (negative regulation of gene expression), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0010038 (response to metal ion), GO:0030100 (regulation of endocytosis), GO:0042177 (negative regulation of protein catabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0042176 (regulation of protein catabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0002718 (regulation of cytokine production involved in immune response), GO:0032880 (regulation of protein localization), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0002820 (negative regulation of adaptive immune response), GO:0051099 (positive regulation of binding), GO:0002719 (negative regulation of cytokine production involved in immune response), GO:0055080 (monoatomic cation homeostasis), GO:0090087 (regulation of peptide transport), GO:0071241 (cellular response to inorganic substance), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0051247 (positive regulation of protein metabolic process), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0043269 (regulation of monoatomic ion transport), GO:0031329 (regulation of cellular catabolic process), GO:0071363 (cellular response to growth factor stimulus), GO:0051174 (regulation of phosphorus metabolic process), GO:2000273 (positive regulation of signaling receptor activity), GO:0032092 (positive regulation of protein binding), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0050863 (regulation of T cell activation), GO:0030162 (regulation of proteolysis), GO:0065003 (protein-containing complex assembly), GO:0045937 (positive regulation of phosphate metabolic process), GO:1901799 (negative regulation of proteasomal protein catabolic process), GO:0010959 (regulation of metal ion transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation), GO:2000059 (negative regulation of ubiquitin-dependent protein catabolic process), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0031401 (positive regulation of protein modification process), GO:1900120 (regulation of receptor binding), GO:0002707 (negative regulation of lymphocyte mediated immunity), GO:0002724 (regulation of T cell cytokine production), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0006879 (intracellular iron ion homeostasis), GO:0071248 (cellular response to metal ion), GO:0002791 (regulation of peptide secretion), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0010039 (response to iron ion), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:2000008 (regulation of protein localization to cell surface), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0045861 (negative regulation of proteolysis), GO:0050868 (negative regulation of T cell activation), GO:0071773 (cellular response to BMP stimulus), GO:0002823 (negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0032091 (negative regulation of protein binding), GO:0001932 (regulation of protein phosphorylation), GO:0002710 (negative regulation of T cell mediated immunity), GO:0032435 (negative regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:1903051 (negative regulation of proteolysis involved in protein catabolic process), GO:0071281 (cellular response to iron ion), GO:0046634 (regulation of alpha-beta T cell activation), GO:1900122 (positive regulation of receptor binding), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0002709 (regulation of T cell mediated immunity), GO:0042325 (regulation of phosphorylation), GO:0034756 (regulation of iron ion transport), GO:0046636 (negative regulation of alpha-beta T cell activation), GO:0030509 (BMP signaling pathway), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:2001185 (regulation of CD8-positive, alpha-beta T cell activation), GO:0060393 (regulation of pathway-restricted SMAD protein phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0009986 (cell surface), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0045177 (apical part of cell), GO:0005615 (extracellular space), GO:0043235 (receptor complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0031410 (cytoplasmic vesicle), GO:0098802 (plasma membrane signaling receptor complex), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0009897 (external side of plasma membrane), GO:0098797 (plasma membrane protein complex), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0055037 (recycling endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)