Protein: Nucleoporin NUP35 (35 kDa nucleoporin) (Nuclear pore complex protein Nup53) (Nucleoporin NUP53) (Nucleoporin npp-19) (Q09601)
Organism: Caenorhabditis elegans
Function: Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Thereby required for nuclear import. Required for the proper organization of chromosomes on the mitotic spindle during anaphase.
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8NFH5}. Nucleus membrane {ECO:0000269|PubMed:12937276, ECO:0000269|PubMed:35852146}.
Sequence: MFSHLNQNTSGRHNSMDLNNSSISNFGTPVEQSTPALLFGKRKATVPSSYTASPLNTASAPCSDIFAVSAPAVPQHLKDTPGSKSVHWSPSLVQSGEKSAAQTQNTPANLSFGGNSSFSAPTKPAPQSIQTSSFGGQAMHAPPLRSLRDKVEPAKKISRRNTFTARSTPLSTPITQRVTSRLAEAEEQPMEEEADAADTWVTVFGFQPSQVSILLNLFSRHGEVVSHQTPSKGNFIHMRYSCVTHAQQAISRNGTLLDQDTFIGVVQCTNKDVINGSASGIVARSSNIAAAANRSASMYNSFVENDMADQSVNHNENSVLNSSNVFDANNSLNSSRISVRSGVGMRPLAADQRTNILQGTPSVRKAPDGLLNKFWNTIGLN
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [197-273]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [195-268]
- IPR007846: RNA-recognition motif (RRM) Nup35-type domain (domain) [193-276]
Interaction partners: - Nucleoporin_N domain-containing protein
- Nsp1_C domain-containing protein
- Nuclear pore protein
- Nuclear Pore complex Protein
- Nuclear pore complex protein 5
- Nucleoporin ndc-1
- Nucleoporin Nup54 alpha-helical domain-containing protein
- Nuclear pore complex protein 15
- WD_REPEATS_REGION domain-containing protein
- Nuclear pore complex protein Nup85
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0051640 (organelle localization), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0043487 (regulation of RNA stability), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0007051 (spindle organization), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0000226 (microtubule cytoskeleton organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0045184 (establishment of protein localization), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:0046907 (intracellular transport), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0007346 (regulation of mitotic cell cycle), GO:0098813 (nuclear chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0010256 (endomembrane system organization), GO:0072594 (establishment of protein localization to organelle), GO:0140014 (mitotic nuclear division), GO:0051248 (negative regulation of protein metabolic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0009792 (embryo development ending in birth or egg hatching), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0051225 (spindle assembly), GO:0006886 (intracellular protein transport), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0031326 (regulation of cellular biosynthetic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0000070 (mitotic sister chromatid segregation), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0061024 (membrane organization), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0006998 (nuclear envelope organization), GO:0031399 (regulation of protein modification process), GO:0006998 (nuclear envelope organization), GO:2001141 (regulation of RNA biosynthetic process), GO:0048285 (organelle fission), GO:0006355 (regulation of DNA-templated transcription), GO:0051276 (chromosome organization), GO:0019220 (regulation of phosphate metabolic process), GO:0071763 (nuclear membrane organization), GO:0006997 (nucleus organization), GO:0000819 (sister chromatid segregation), GO:0071709 (membrane assembly), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0048284 (organelle fusion), GO:0045936 (negative regulation of phosphate metabolic process), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0000280 (nuclear division), GO:0042326 (negative regulation of phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0030261 (chromosome condensation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0065004 (protein-DNA complex assembly), GO:0051649 (establishment of localization in cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)