Protein: Thymidylate kinase (PfTMK) (PfTMPK) (EC 2.7.4.8) (EC 2.7.4.9) (Thymidine monophosphate kinase) (Thymidylate/guanylate kinase) (Q8I4S1)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP. Can also phosphorylate dGMP and to a lesser extent GMP, dUMP and dIMP. Can use either ATP or dATP as phosphate donors in presence of Mg(2+).
Sequence: MTDDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIGQIISKYLKMENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAYSGVAYSSGALNLNKTWCMNPDQGLIKPDVVFYLNVPPNYAQNRSDYGEEIYEKVETQKKIYETYKHFAHEDYWINIDATRKIEDIHNDIVKEVTKIKVEPEEFNFLWS
InterPro domains: - IPR018095: Thymidylate kinase, conserved site (conserved_site) [96-108]
- IPR039430: Thymidylate kinase-like domain (domain) [13-191]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-210]
- IPR018094: Thymidylate kinase (family) [7-199]
Interaction partners: - Bifunctional dihydrofolate reductase-thymidylate synthase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Ribonucleoside-diphosphate reductase
- Nucleoside diphosphate kinase
- nucleoside-diphosphate kinase
- Ribonucleoside-diphosphate reductase small chain, putative
- Ribonucleoside-diphosphate reductase small chain, putative
- Uncharacterized protein
- orotate phosphoribosyltransferase
- Thioredoxin-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016776 (phosphotransferase activity, phosphate group as acceptor), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0050145 (nucleoside monophosphate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019692 (deoxyribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0009262 (deoxyribonucleotide metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0046385 (deoxyribose phosphate biosynthetic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0009263 (deoxyribonucleotide biosynthetic process), GO:0009394 (2'-deoxyribonucleotide metabolic process), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0009265 (2'-deoxyribonucleotide biosynthetic process), GO:0009133 (nucleoside diphosphate biosynthetic process), GO:0009219 (pyrimidine deoxyribonucleotide metabolic process), GO:0009147 (pyrimidine nucleoside triphosphate metabolic process), GO:0009138 (pyrimidine nucleoside diphosphate metabolic process), GO:0009186 (deoxyribonucleoside diphosphate metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006221 (pyrimidine nucleotide biosynthetic process), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009221 (pyrimidine deoxyribonucleotide biosynthetic process), GO:0009148 (pyrimidine nucleoside triphosphate biosynthetic process), GO:0009139 (pyrimidine nucleoside diphosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)