Protein: Presenilin sel-12 (Suppressor/enhancer of lin-12 protein 12) (P52166)
Organism: Caenorhabditis elegans
Function: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Sequence: MPSTRRQQEGGGADAETHTVYGTNLITNRNSQEDENVVEEAELKYGASHVIHLFVPVSLCMALVVFTMNTITFYSQNNGRHLLYTPFVRETDSIVEKGLMSLGNALVMLCVVVLMTVLLIVFYKYKFYKLIHGWLIVSSFLLLFLFTTIYVQEVLKSFDVSPSALLVLFGLGNYGVLGMMCIHWKGPLRLQQFYLITMSALMALVFIKYLPEWTVWFVLFVISVWDLVAVLTPKGPLRYLVETAQERNEPIFPALIYSSGVIYPYVLVTAVENTTDPREPTSSDSNTSTAFPGEASCSSETPKRPKVKRIPQKVQIESNTTASTTQNSGVRVERELAAERPTVQDANFHRHEEEERGVKLGLGDFIFYSVLLGKASSYFDWNTTIACYVAILIGLCFTLVLLAVFKRALPALPISIFSGLIFYFCTRWIITPFVTQVSQKCLLY
InterPro domains: - IPR001686: Peptidase A22A, presenilin, nematode type (family) [24-353]
- IPR042524: Presenilin, C-terminal (homologous_superfamily) [334-436]
- IPR006639: Presenilin/signal peptide peptidase (family) [99-430]
- IPR001108: Peptidase A22A, presenilin (family) [30-442]
Interaction partners: - Gamma-secretase subunit pen-2
- Nicastrin
- Gamma-secretase subunit aph-1
- Protein lin-12
- Beta-catenin-like protein hmp-2
- Beta-catenin/armadillo-related protein 1
- cAMP-dependent protein kinase catalytic subunit
- Presenilin spe-4
- Presenilin hop-1
- Armadillo repeat-containing protein wrm-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:1901564 (organonitrogen compound metabolic process), GO:0002027 (regulation of heart rate), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0007166 (cell surface receptor signaling pathway), GO:0050877 (nervous system process), GO:0043170 (macromolecule metabolic process), GO:0007613 (memory), GO:0050890 (cognition), GO:0007447 (imaginal disc pattern formation), GO:0007220 (Notch receptor processing), GO:0006508 (proteolysis), GO:0008593 (regulation of Notch signaling pathway), GO:0051604 (protein maturation), GO:0007612 (learning), GO:0007444 (imaginal disc development), GO:0006811 (monoatomic ion transport), GO:0010467 (gene expression), GO:1903522 (regulation of blood circulation), GO:0007219 (Notch signaling pathway), GO:0035220 (wing disc development), GO:0007450 (dorsal/ventral pattern formation, imaginal disc), GO:0008016 (regulation of heart contraction), GO:0006812 (monoatomic cation transport), GO:0033619 (membrane protein proteolysis), GO:0007614 (short-term memory), GO:0035222 (wing disc pattern formation), GO:0008306 (associative learning), GO:0031293 (membrane protein intracellular domain proteolysis), GO:0030001 (metal ion transport), GO:0048190 (wing disc dorsal/ventral pattern formation), GO:0000041 (transition metal ion transport), GO:0006825 (copper ion transport), GO:0015677 (copper ion import)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0009986 (cell surface), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0045177 (apical part of cell), GO:1902494 (catalytic complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0016324 (apical plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0031982 (vesicle), GO:0099513 (polymeric cytoskeletal fiber), GO:0097708 (intracellular vesicle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton), GO:0005884 (actin filament)