Protein: T-complex protein 1 subunit epsilon (CCT-epsilon) (V9HW37)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [154-416]
- IPR053374: TCP-1 chaperonin-containing T-complex (family) [15-533]
- IPR017998: Chaperone tailless complex polypeptide 1 (TCP-1) (family) [30-534]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [221-389]
- IPR054827: Thermosome subunit alpha (family) [15-533]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [44-533]
- IPR002194: Chaperonin TCP-1, conserved site (conserved_site) [49-106]
- IPR012718: T-complex protein 1, epsilon subunit (family) [6-536]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [25-533]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044183 (protein folding chaperone), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0008092 (cytoskeletal protein binding), GO:0031681 (G-protein beta-subunit binding), GO:0003723 (RNA binding), GO:0015631 (tubulin binding), GO:0003729 (mRNA binding), GO:0048487 (beta-tubulin binding), GO:0048027 (mRNA 5'-UTR binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0065008 (regulation of biological quality), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0032879 (regulation of localization), GO:0006457 (protein folding), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:1903829 (positive regulation of protein localization), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0060341 (regulation of cellular localization), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0061077 (chaperone-mediated protein folding), GO:0031647 (regulation of protein stability), GO:0051128 (regulation of cellular component organization), GO:0009615 (response to virus), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051052 (regulation of DNA metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0051054 (positive regulation of DNA metabolic process), GO:0070201 (regulation of establishment of protein localization), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0050821 (protein stabilization), GO:0032880 (regulation of protein localization), GO:1900182 (positive regulation of protein localization to nucleus), GO:0010638 (positive regulation of organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2000573 (positive regulation of DNA biosynthetic process), GO:2001252 (positive regulation of chromosome organization), GO:0032206 (positive regulation of telomere maintenance), GO:0032204 (regulation of telomere maintenance), GO:2000278 (regulation of DNA biosynthetic process), GO:1900180 (regulation of protein localization to nucleus), GO:0033044 (regulation of chromosome organization), GO:0032210 (regulation of telomere maintenance via telomerase), GO:0032212 (positive regulation of telomere maintenance via telomerase), GO:1904356 (regulation of telomere maintenance via telomere lengthening), GO:1904358 (positive regulation of telomere maintenance via telomere lengthening)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0140535 (intracellular protein-containing complex), GO:0099080 (supramolecular complex), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0101031 (chaperone complex), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0005832 (chaperonin-containing T-complex), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0031982 (vesicle), GO:0099513 (polymeric cytoskeletal fiber), GO:1903561 (extracellular vesicle), GO:0005856 (cytoskeleton), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)