Protein: Frizzled-10 (Fz-10) (CD antigen CD350) (Q8BKG4)
Organism: Mus musculus (Mouse)
Function: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:15923619}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MQHPGPRLWLVLQVMIGSCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQREAAIQLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFKFRWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAGCDNPGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKMNNQTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPAQPSACV
InterPro domains: - IPR036790: Frizzled cysteine-rich domain superfamily (homologous_superfamily) [31-155]
- IPR015526: Frizzled/secreted frizzled-related protein (family) [30-533]
- IPR020067: Frizzled domain (domain) [30-153]
- IPR017981: GPCR, family 2-like, 7TM (domain) [228-531]
- IPR000539: Frizzled/Smoothened, 7TM (domain) [218-542]
Interaction partners: - Protein Wnt-7a
- Proto-oncogene Wnt-1
- Protein Wnt-11
- Protein Wnt-7b
- Tyrosine-protein kinase RYK
- E3 ubiquitin-protein ligase RNF43
- E3 ubiquitin-protein ligase ZNRF3
- Low-density lipoprotein receptor-related protein 5
- Protein Wnt-3a
- Low-density lipoprotein receptor-related protein 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0042813 (Wnt receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0045321 (leukocyte activation), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0007267 (cell-cell signaling), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0021700 (developmental maturation), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0001763 (morphogenesis of a branching structure), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0048729 (tissue morphogenesis), GO:0012501 (programmed cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0001817 (regulation of cytokine production), GO:0046649 (lymphocyte activation), GO:0044087 (regulation of cellular component biogenesis), GO:0071695 (anatomical structure maturation), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048469 (cell maturation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0001819 (positive regulation of cytokine production), GO:0051128 (regulation of cellular component organization), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:1902742 (apoptotic process involved in development), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0001568 (blood vessel development), GO:0008285 (negative regulation of cell population proliferation), GO:0060706 (cell differentiation involved in embryonic placenta development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0061138 (morphogenesis of a branching epithelium), GO:0060561 (apoptotic process involved in morphogenesis), GO:0009891 (positive regulation of biosynthetic process), GO:0001525 (angiogenesis), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0060711 (labyrinthine layer development), GO:0080090 (regulation of primary metabolic process), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0055123 (digestive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0016055 (Wnt signaling pathway), GO:0001944 (vasculature development), GO:0090596 (sensory organ morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0060669 (embryonic placenta morphogenesis), GO:0048568 (embryonic organ development), GO:0002064 (epithelial cell development), GO:0072359 (circulatory system development), GO:0032732 (positive regulation of interleukin-1 production), GO:1902533 (positive regulation of intracellular signal transduction), GO:0060674 (placenta blood vessel development), GO:0060716 (labyrinthine layer blood vessel development), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0048562 (embryonic organ morphogenesis), GO:1901888 (regulation of cell junction assembly), GO:0007423 (sensory organ development), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0010628 (positive regulation of gene expression), GO:0032652 (regulation of interleukin-1 production), GO:0001890 (placenta development), GO:0030855 (epithelial cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048514 (blood vessel morphogenesis), GO:0060713 (labyrinthine layer morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:0042110 (T cell activation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051338 (regulation of transferase activity), GO:0060429 (epithelium development), GO:0002070 (epithelial cell maturation), GO:0048565 (digestive tract development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060575 (intestinal epithelial cell differentiation), GO:0048592 (eye morphogenesis), GO:0002066 (columnar/cuboidal epithelial cell development), GO:0045937 (positive regulation of phosphate metabolic process), GO:0001892 (embryonic placenta development), GO:2001141 (regulation of RNA biosynthetic process), GO:0031076 (embryonic camera-type eye development), GO:0150063 (visual system development), GO:0032651 (regulation of interleukin-1 beta production), GO:0060070 (canonical Wnt signaling pathway), GO:0043549 (regulation of kinase activity), GO:1903131 (mononuclear cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0031401 (positive regulation of protein modification process), GO:0032731 (positive regulation of interleukin-1 beta production), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0043408 (regulation of MAPK cascade), GO:0043009 (chordate embryonic development), GO:0051347 (positive regulation of transferase activity), GO:0001654 (eye development), GO:0048048 (embryonic eye morphogenesis), GO:0030217 (T cell differentiation), GO:0031399 (regulation of protein modification process), GO:0006355 (regulation of DNA-templated transcription), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0019220 (regulation of phosphate metabolic process), GO:2000810 (regulation of bicellular tight junction assembly), GO:0032680 (regulation of tumor necrosis factor production), GO:0001932 (regulation of protein phosphorylation), GO:0001701 (in utero embryonic development), GO:0045859 (regulation of protein kinase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0002068 (glandular epithelial cell development), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0043406 (positive regulation of MAP kinase activity), GO:0048596 (embryonic camera-type eye morphogenesis), GO:0001934 (positive regulation of protein phosphorylation), GO:0002067 (glandular epithelial cell differentiation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0060576 (intestinal epithelial cell development), GO:0033077 (T cell differentiation in thymus), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0043507 (positive regulation of JUN kinase activity), GO:0045860 (positive regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:0043506 (regulation of JUN kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0098858 (actin-based cell projection), GO:0031253 (cell projection membrane), GO:0030175 (filopodium)