Protein: Kunitz-type protease inhibitor 1a precursor (Serine protease inhibitor, Kunitz type 1 b) (Spint1a protein) (Q7T363)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MTLAQLRLFGTAVFLLLFLHQSPSAAQEEEKLCKDKFSVGKEDFVLNTDESVKEGATFLGSPQVSKPEDCVMACCNDPNCNLALMEHREDPKSINTCFIINCLYKQKKVCHFVRKKGFTNYLRKSVFSDYLEQKATDVEDRPPRARAGQDRVVQPNEDVTLNGIESSDDKKIVKYEWEQVVGDPSAVMTKGHFADSVTVSNLSPGMYKFRLTVSDEAGQTGSAEVSILVLTREQSLHHCLVPKKEGPCRGSFPRWHYNAATEKCEEFKFGGCVPNRNNYLALNECQSACNKVSVSNIGSPAPHPSGRIGPIDAVEQCDRPCSPEHFTCDNKCCIGKDLVCDKEKQCSDGSDEKECDKWDYDLVKLRGISPDVSKARCVKPPVTGTCPGSQTKWYYNPNKRLCYRFNYGGCEGNQNRFETEAGCMTFCSGVTENDKFPEESQFDKQEGKSNNTVAIVMVIILAFAIAILLVIIIAYCLVKGRKKSRNKHQQLAVNGGHIYRYEDSEKLVYNSTTKPI
InterPro domains: - IPR011106: Seven cysteines, N-terminal (domain) [28-121]
- IPR022409: PKD/Chitinase domain (domain) [144-232]
- IPR020901: Proteinase inhibitor I2, Kunitz, conserved site (conserved_site) [267-423]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [143-233]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [333-355]
- IPR036880: Pancreatic trypsin inhibitor Kunitz domain superfamily (homologous_superfamily) [234-430]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [316-360]
- IPR002223: Pancreatic trypsin inhibitor Kunitz domain (domain) [236-428]
- IPR013980: MANSC domain (domain) [33-121]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [320-357]
- IPR035986: PKD domain superfamily (homologous_superfamily) [141-230]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0004857 (enzyme inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0030414 (peptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0008283 (cell population proliferation), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0097529 (myeloid leukocyte migration), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0071621 (granulocyte chemotaxis), GO:0060326 (cell chemotaxis), GO:0097530 (granulocyte migration), GO:0043062 (extracellular structure organization), GO:0008544 (epidermis development), GO:0002009 (morphogenesis of an epithelium), GO:0045229 (external encapsulating structure organization), GO:0060429 (epithelium development), GO:0097435 (supramolecular fiber organization), GO:0030198 (extracellular matrix organization), GO:0030593 (neutrophil chemotaxis), GO:0030199 (collagen fibril organization), GO:1990266 (neutrophil migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)