Protein: NPHS1 adhesion molecule, nephrin (A0A8M9QPY5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MDSWLSLVFLSGCFLLLVDFKGVCGQQAFKTEPRNVTVRAGATALLKCEVLRASGAVQWVKDGLLLGPLRSLPGYPRYSMTGDQKKGQYHLQILDVTLEDDGPYECQVGRSESSRPIVSRTVWLNVQIPSSQPYFQLESEEPWVEGEQYTVTCIAPDAKPPAEITMFRDGEELLESESYTMSGSQDKLQNTHAEVTIRARSSDDTRRLTCRAKNPASPRALETGMTMKVYFPPQAPMIMGLENEEVKAGSFLKVVCMSYGGNPLATLHWTKNGEVLSTSWDVDFVSRRASSVLKMEVKPEDNHAVLQCQSINQVTRSPMSLTRTLTVLFEPAEVTLLGSFEAVEGEEINLSCSTSSSNPPVHIRWWLGFKELNRTEVTFAEGDNGGMMTVSNLTHKVSREDNGLSLQCEAFNKGTRFSSVRAAELIVYYPPQKVWLDAPPPNVFLHSGSTLRLVCFSSGGNPTGQLTWLKNNKVVLTASKQVSSERGVSRELLLILHPSDNLATYRCDSSNKAKKVLSTQTKFRVLFPAVSVKIVAKQKELRRGQTLDLDCLAGSSNPTANISWSLGPVILKGVDQAPKRAEFGGMSRTSKLSLTLESHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSDEQPDEVQVIEDETATLPAKVSANPDEITCEWIFQGEKLVKERDPRYTFSDWTLEIVNVSRRDGGDYIIECSNAEGSNRTKLRLDVQYSPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKWMGEGERDELGEESEDDGTGVLTIYEVTRDRAGVYQCTADNGISPTGSVEGQLIVRFAPDLQKGPQWRKVASRGDGSNDANVVCQAQGVPRVQFRWAKNGFPLDLGNPRYEETTESTGTIHTSILTVINVSAALDYAIFTCTAHNSMGEDSLDIQLLSTNHPDPPSDLKLLRVDQTSVTLEWMPGFDGGLTQIFRVRYQWAGSASYMYVDVFPPTATVYTVTGLNPSTMYNFSVNALNSIGESSYADNNKILMVTTADAKEADGGVSTADQDSALAGGGLPVYVVVILVVGGVLFLLNPFICFLLARWKRRRSLKGDTSSISQETKSEEQRSTASSSTRYASRELINASAQRTLLVDSSSEPDSSVYESYGRQENPHYYYPTEAYSPALYAHPEGPEDYDGRHGTSPFTHVYEEVRGMYEDLQACSPLPPAAHIHPQAPFSTYYEGRAYSKADVDVTIGAYDSMVYRRRRDTDLPFELRGELV
InterPro domains: - IPR013098: Immunoglobulin I-set (domain) [28-915]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [23-924]
- IPR007110: Immunoglobulin-like domain (domain) [27-914]
- IPR003598: Immunoglobulin subtype 2 (domain) [39-907]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [441-512]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [907-1006]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [24-1021]
- IPR051275: Cellular adhesion and signaling domain-containing protein (family) [15-335]
- IPR003961: Fibronectin type III (domain) [921-1018]
- IPR013162: CD80-like, immunoglobulin C2-set (domain) [139-612]
- IPR003599: Immunoglobulin domain subtype (domain) [33-918]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0035295 (tube development), GO:0001945 (lymph vessel development), GO:0036303 (lymph vessel morphogenesis), GO:0001946 (lymphangiogenesis), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)