wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: SERPINE1 mRNA-binding protein 1 (Q9CY58)
Organism: Mus musculus (Mouse)
Function: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A- site of the ribosome and promoting ribosome stabilization and storage in an inactive state. May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). Seems to play a role in PML-nuclear bodies formation (By similarity)
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region
Sequence: MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVADKKEETQPPVALKKEGIRRVGRRPDQQLQGDGKLIDRRAERRPPRERRFEKPLEEKGEGGEFSVDRPIIERPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLDQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA
InterPro domains: - IPR032381: Intracellular hyaluronan-binding protein 4, N-terminal domain (domain) [5-151]
- IPR039764: RNA binding protein HABP4/SERBP1-like (family) [14-407]
- IPR006861: Hyaluronan/mRNA-binding protein (domain) [189-313]
Interaction partners: - Small ribosomal subunit protein RACK1
- Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS10
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein eL15
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL15
- Small ribosomal subunit protein uS5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0050794 (regulation of cellular process), GO:0010941 (regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0030054 (cell junction), GO:0045202 (synapse)
Protein: SERPINE1 mRNA-binding protein 1 (G1SW77)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A- site of the ribosome and promoting ribosome stabilization and storage in an inactive state. May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (By similarity)
Sequence: MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPNVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGEGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLDQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA
InterPro domains: - IPR032381: Intracellular hyaluronan-binding protein 4, N-terminal domain (domain) [5-151]
- IPR039764: RNA binding protein HABP4/SERBP1-like (family) [14-407]
- IPR006861: Hyaluronan/mRNA-binding protein (domain) [189-313]
Interaction partners: - Uncharacterized protein
- Uncharacterized protein
- Uncharacterized protein
- Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Small ribosomal subunit protein uS7
- Small ribosomal subunit protein uS19
- Large ribosomal subunit protein eL20
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS28
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0017022 (myosin binding), GO:0045159 (myosin II binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0006997 (nucleus organization), GO:0030575 (nuclear body organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)
Protein: Probable serpin E3 (B0UYL8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probable serine protease inhibitor
Subcellular location: Secreted
Sequence: MPQLSASSLFICLWLVDLCHVANSVLSSSFSDLHTQFGISLYQTLTETENKSNLIVSPASVSLCLGLLQLGARGNTLVQLEGTLGYDVNDVRVQNILSRPQGDLANSSEGLRLQLANALFIQTGVKLLPEFTQHALGWGNTSLLSVNFSNPNHTHSRLQQWAHYQSKADDHLQTREELHHSSGEEEEATRQDHLLYMALVSTLVFHGAWQKQFLFTETQNLPFTFSDGSTVKVPMMYQSSEVNIGHFRLPSEQEYTVLELPYLDHSLRLLVALPSDRKTPLSQLEKQITARAVGLWDTGLRRTKMDIFLPRFKMQSKINLKPVLQSLGVSDIFSPSAADFRGISDTDGIFVSEAFHEARIEVTEAGTKAASATAMVLLKRSRSAVFKADRPFLFILRQISTGSLLFIGRVVNPADMP
InterPro domains: - IPR036186: Serpin superfamily (homologous_superfamily) [29-413]
- IPR031172: Serpin E3 (family) [22-413]
- IPR042178: Serpin superfamily, domain 1 (homologous_superfamily) [41-379]
- IPR042185: Serpin superfamily, domain 2 (homologous_superfamily) [205-413]
- IPR023796: Serpin domain (domain) [34-413]
- IPR023795: Serpin, conserved site (conserved_site) [386-396]
- IPR000215: Serpin family (family) [30-413]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0031099 (regeneration), GO:0042246 (tissue regeneration), GO:0031101 (fin regeneration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Transcription factor SFL1 (Q5A287)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia
Subcellular location: Nucleus. Note=Localizes to the nucleus in both yeast and hyphal cells
Sequence: MSHLVSSSLGTTTTATPTSRSPHTNHSTPYNQNSITSNRSSPVPKNSVNSRIIPQTMNPPIDMKSNNILNPEKDTDTSRGDHSESKASSISSASGTTTTNNNNVSNNNSTGKTQIVFIHKLYDMLHDESISHLIWWSPSLDSFYVTPGEEFSRVLSQYFKHTNIASFIRQLNMYGFHKVNEPFLNQDDQQQQQQLQSNRWEFRHSTNQFRKGDTESLKNIKRRSSKTLNAQKEVVNIKSLPPTSHPMEYNTGYSYQNEDSAHYFVHHHSITTMQSPADMRPRSPSTPIPMQPLAQQQQQQQQQQQQQQQQLPSQPVPNGPPVFSGPIPPGAVNQSPQEYLTRPSILNNVQGSFENATNFKFVELTNQINLLRNDFFTMNNRYEILQNELKYQTADSMAVLEILEKLSNDNRIATDIRDLKNVVSQRMQRLNNQFIPQQSNFAPHIPGQQQQQQHGNSVSSNYHLESTNVSRNPSTTNLNVAPQPYPLNPHYTIYANNRASGSSEINNGVFRAREDSNNSKRNLSVYDPLQPVPSRNSSRILIEESTPTHPPTNFNPQQSQSQSQVQLGPAMPPQGFRNRAESTYSPLSHSSNKSQILNKAPTPVNHSPLVQQQQKEAKQELNDSSVAPPSQSSLPVTRPLSRQQQQQQQTLHHPSTTSSRTNSLPNPVAEHPAPQSSYFMQRNSFNTVYEHQKSLRVPSPKRVRYATPPRSIPEQPISSTAPTTMITSTSKPTSTSGAAISRSENHSVVSLTGGALPSVSELDKSIRTGSSVSLPPIKSIKDNDNKNDNGNSDDNGNDHKKRKLE
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [116-223]
- IPR000232: Heat shock factor (HSF)-type, DNA-binding (domain) [113-223]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [110-225]
Interaction partners: - Transcription activator TEC1
- Transcriptional regulator NRG1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0040007 (growth), GO:0009987 (cellular process), GO:0030447 (filamentous growth), GO:0009628 (response to abiotic stimulus), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Sideroflexin-5 (Q925N0)
Organism: Mus musculus (Mouse)
Function: Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MADTATTASAASAAASAPNASTDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTEKRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDADGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVHSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIARATSSRTVVYNKGL
InterPro domains: - IPR004686: Tricarboxylate/iron carrier (family) [26-342]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015746 (citrate transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006842 (tricarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Homeobox protein SIX5 (Q8N196)
Organism: Homo sapiens (Human)
Function: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity)
Subcellular location: Cytoplasm. Nucleus
Sequence: MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVALQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEPLEL
InterPro domains: - IPR001356: Homeodomain (domain) [201-263]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [199-259]
- IPR017970: Homeobox, conserved site (conserved_site) [234-257]
- IPR031701: Homeobox protein SIX1, N-terminal SD domain (domain) [86-196]
Interaction partners: - Protein phosphatase EYA1
- Zinc finger protein 143
- Dystrophia myotonica WD repeat-containing protein
- Transcriptional repressor CTCF
- Myotonin-protein kinase
- Protein phosphatase EYA3
- Muscleblind-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Probable protease SohB (P0AG14)
Organism: Escherichia coli (strain K12)
Function: Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability
Subcellular location: Cell inner membrane; Single-pass membrane protein
Sequence: MELLSEYGLFLAKIVTVVLAIAAIAAIIVNVAQRNKRQRGELRVNNLSEQYKEMKEELAAALMDSHQQKQWHKAQKKKHKQEAKAAKAKAKLGEVATDSKPRVWVLDFKGSMDAHEVNSLREEITAVLAAFKPQDQVVLRLESPGGMVHGYGLAASQLQRLRDKNIPLTVTVDKVAASGGYMMACVADKIVSAPFAIVGSIGVVAQMPNFNRFLKSKDIDIELHTAGQYKRTLTLLGENTEEGREKFREELNETHQLFKDFVKRMRPSLDIEQVATGEHWYGQQAVEKGLVDEINTSDEVILSLMEGREVVNVRYMQRKRLIDRFTGSAAESADRLLLRWWQRGQKPLM
InterPro domains: - IPR013703: Peptidase S49, N-terminal proteobacteria (domain) [2-158]
- IPR047272: Signal peptide peptidase A-like, C-terminal (domain) [102-305]
- IPR029045: ClpP/crotonase-like domain superfamily (homologous_superfamily) [100-299]
- IPR002142: Peptidase S49 (domain) [161-310]
Interaction partners: - Uncharacterized oxidoreductase YciK
- Corrinoid adenosyltransferase
- Corrinoid adenosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0033554 (cellular response to stress), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006974 (cellular response to DNA damage stimulus), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Serine proteinase inhibitor 2 (P07385)
Organism: Cowpox virus (strain Brighton Red) (CPV)
Function: Viral serpin that inhibits both cysteine and serine proteinases involved in the regulation of host inflammatory and apoptosis processes. Major anti-apoptotic protein which inhibits both intrinsic and extrinsic pathways and strongly cleaves host CASP1 and CASP8 but is a rather poor inhibitor of host CASP3. Prevents the proteolytic activity of host interleukin-1-beta converting enzyme (ICE) and ICE-like enzymes. Can also block apoptosis through host tumor necrosis factor (TNF) receptor
Subcellular location: Host cytoplasm
Sequence: MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLSKYVEKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQTVDFTDCRTVDAINKCVDIFTEGKINPLLDEPLSPDTCLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWCDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMCNSDVSVDAMIHKTYIDVNEEYTEAAAATCALVADCASTVTNEFCADHPFIYVIRHVDGKILFVGRYCSPTTN
InterPro domains: - IPR036186: Serpin superfamily (homologous_superfamily) [1-338]
- IPR042178: Serpin superfamily, domain 1 (homologous_superfamily) [73-297]
- IPR042185: Serpin superfamily, domain 2 (homologous_superfamily) [133-293]
- IPR023796: Serpin domain (domain) [1-338]
- IPR023795: Serpin, conserved site (conserved_site) [312-322]
- IPR000215: Serpin family (family) [4-339]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Stationary-phase-induced ribosome-associated protein (P68191)
Organism: Escherichia coli (strain K12)
Function: Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein
Subcellular location: Cytoplasm. Note=Enriched in the periphery of the cell, excluded from the nucleoid
Sequence: MKSNRQARHILGLDHKISNQRKIVTEGDKSSVVNNPTGRKRPAEK
InterPro domains: - IPR012607: Ribosome hibernation factor SRA (family) [1-44]
Interaction partners: - Small ribosomal subunit protein bS16
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein bS16
- Small ribosomal subunit protein bS18
- Ribosome-associated ATPase
- Small ribosomal subunit protein uS9
- Ribosome-associated factor Y
- Ribosome-associated factor Y
- Ribosome-associated inhibitor A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0004857 (enzyme inhibitor activity), GO:0008047 (enzyme activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0022627 (cytosolic small ribosomal subunit), GO:0015935 (small ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005840 (ribosome)
Protein: Sarcospan (Q62147)
Organism: Mus musculus (Mouse)
Function: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions
Sequence: MGRKPSPRAQELPEEEARTCCGCRFPLLLALLQLALGIAVTVLGFLMASISPSLLVRDTPFWAGSIVCVVAYLGLFMLCVSYQVDERTCVQFSMKVFYFLLSALGLMVCMLAVAFAAHHYSLLAQFTCETSLDSCQCKLPSSEPLSRAFVYRDVTDCTSVTGTFKLFLIIQMVLNLVCGLVCLLACFVMWKHRYQVFYVGVGLRSLMASDGQLPKA
InterPro domains: - IPR030429: Sarcospan (family) [4-215]
- IPR007237: CD20-like family (family) [28-183]
Interaction partners: - Dystrophin
- Dystroglycan 1
- Dystrobrevin alpha
- Delta-sarcoglycan
- Alpha-sarcoglycan
- Beta-sarcoglycan
- Utrophin
- Gamma-sarcoglycan
- Epsilon-sarcoglycan
- Zeta-sarcoglycan
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0007155 (cell adhesion), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0006936 (muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane), GO:0042383 (sarcolemma)