Protein: D(1B) dopamine receptor (D(5) dopamine receptor) (Dopamine D5 receptor) (Q8BLD9)
Organism: Mus musculus (Mouse)
Function: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MLPPGRNGTAHRARLGLQRQLAQVDAPGGSAAPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVALAWTLSILISFIPVQLNWHRDKAGSQGREGLLSNETPWEEGWELDGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGACEPDPSLRASIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCSSGDAQGPRTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHLCFRTPVQTVNISNELISYNQDTVFHREIAAAYVHMIPNAVSSGDREVGEEEEAEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFHKTA
InterPro domains: - IPR000929: Dopamine receptor family (family) [60-369]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [55-354]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [40-368]
- IPR000497: Dopamine D5 receptor (family) [38-413]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Pro-opiomelanocortin
- VIP peptides
- Pro-glucagon
- Pituitary adenylate cyclase-activating polypeptide
- Natriuretic peptides A
- Gastric inhibitory polypeptide
- Thyrotropin subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0004952 (dopamine neurotransmitter receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0003008 (system process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0040013 (negative regulation of locomotion), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0007610 (behavior), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:2000145 (regulation of cell motility), GO:0009314 (response to radiation), GO:0044092 (negative regulation of molecular function), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:1901698 (response to nitrogen compound), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007632 (visual behavior), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:2000146 (negative regulation of cell motility), GO:0007212 (dopamine receptor signaling pathway), GO:0071417 (cellular response to organonitrogen compound), GO:0050890 (cognition), GO:0009416 (response to light stimulus), GO:0043086 (negative regulation of catalytic activity), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0051248 (negative regulation of protein metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0007612 (learning), GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway), GO:0030334 (regulation of cell migration), GO:0071869 (response to catecholamine), GO:0030336 (negative regulation of cell migration), GO:0008542 (visual learning), GO:0010243 (response to organonitrogen compound), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0014070 (response to organic cyclic compound), GO:0051338 (regulation of transferase activity), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:1901701 (cellular response to oxygen-containing compound), GO:0051174 (regulation of phosphorus metabolic process), GO:0071870 (cellular response to catecholamine stimulus), GO:1903350 (response to dopamine), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0071868 (cellular response to monoamine stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0071867 (response to monoamine), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0008306 (associative learning), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:1903351 (cellular response to dopamine), GO:0006469 (negative regulation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0098862 (cluster of actin-based cell projections), GO:0120025 (plasma membrane bounded cell projection), GO:0005903 (brush border), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0031253 (cell projection membrane), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0031526 (brush border membrane), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane), GO:0030424 (axon), GO:0044309 (neuron spine)