Protein: Disease resistance RPP13-like protein 4 (Disease resistance protein ZAR1) (Protein HOPZ-ACTIVATED RESISTANCE 1) (AtZAR1) (Q38834)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: CC-NB-LRR receptor-like protein required for recognition of pathogenic bacteria type III effectors (T3E) such as Pseudomonas syringae HopZ1a and HopF2a and Xanthomonas campestris pv. campestris (Xcc) XopAC/AvrAC; this recognition requires ZED1-related kinases (e.g. PBL2, ZRK3 and ZED1/ZRK5). Confers allele-specific recognition and virulence attenuation of HopZ1a. Immunity mediated by RPP13L4/ZAR1 is independent of several genes required by other resistance protein signaling pathways such as NDR1 and RAR1. Together with ZED1/ZRK5, involved in the regulation of the ambient temperature-sensitive intersection of growth and immune response in the absence of pathogens.
Subcellular location: Cell membrane {ECO:0000269|PubMed:30948527}. Nucleus {ECO:0000269|PubMed:28652264}. Note=Associates with the plasma membrane in the presence of the Xanthomonas campestris effector XopAC/AvrAC. {ECO:0000269|PubMed:30948527}.
Sequence: MVDAVVTVFLEKTLNILEEKGRTVSDYRKQLEDLQSELKYMQSFLKDAERQKRTNETLRTLVADLRELVYEAEDILVDCQLADGDDGNEQRSSNAWLSRLHPARVPLQYKKSKRLQEINERITKIKSQVEPYFEFITPSNVGRDNGTDRWSSPVYDHTQVVGLEGDKRKIKEWLFRSNDSQLLIMAFVGMGGLGKTTIAQEVFNDKEIEHRFERRIWVSVSQTFTEEQIMRSILRNLGDASVGDDIGTLLRKIQQYLLGKRYLIVMDDVWDKNLSWWDKIYQGLPRGQGGSVIVTTRSESVAKRVQARDDKTHRPELLSPDNSWLLFCNVAFAANDGTCERPELEDVGKEIVTKCKGLPLTIKAVGGLLLCKDHVYHEWRRIAEHFQDELRGNTSETDNVMSSLQLSYDELPSHLKSCILTLSLYPEDCVIPKQQLVHGWIGEGFVMWRNGRSATESGEDCFSGLTNRCLIEVVDKTYSGTIITCKIHDMVRDLVIDIAKKDSFSNPEGLNCRHLGISGNFDEKQIKVNHKLRGVVSTTKTGEVNKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPARSNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNLVKMQEPFWGNENTHWRIEGLMLSSLSDLDMDWEVLQQSMPYLRTVTANWCPELESFAIEDVGFRGGVWMKTPLHRT
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [498-838]
- IPR055414: Disease resistance R13L4/SHOC-2-like, LRR domain (domain) [551-772]
- IPR042197: Apoptotic protease-activating factors, helical domain (homologous_superfamily) [318-412]
- IPR041118: Disease resistance, N-terminal (domain) [5-90]
- IPR038005: Virus X resistance protein-like, coiled-coil domain (domain) [3-127]
- IPR002182: NB-ARC (domain) [164-410]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [149-421]
- IPR044974: Disease resistance protein, plants (family) [31-830]
Interaction partners: - Probable serine/threonine-protein kinase PBL2
- Serine/threonine-protein kinase ZRK1
- Non-functional pseudokinase ZED1
- Toll/interleukin-1 receptor-like protein
- Probable disease resistance protein At5g45510
- Similarity to unknown protein
- RING-type E3 ubiquitin transferase
- Heavy metal-associated isoprenylated plant protein 33
- Heavy metal-associated isoprenylated plant protein 43
- AT5G12460.1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0008219 (cell death), GO:0006952 (defense response), GO:0012501 (programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0051702 (biological process involved in interaction with symbiont), GO:0033554 (cellular response to stress), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0009626 (plant-type hypersensitive response), GO:0034050 (programmed cell death induced by symbiont)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)