Protein: BRCA1 associated RING domain 1 (A0AVN2)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHMDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS
InterPro domains: - IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [66-75]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [420-555]
- IPR039503: BARD1, Zinc finger, RING-type (domain) [33-118]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [26-122]
- IPR002110: Ankyrin repeat (repeat) [427-525]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [568-776]
- IPR001357: BRCT domain (domain) [560-777]
- IPR001841: Zinc finger, RING-type (domain) [50-86]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0046983 (protein dimerization activity), GO:0019787 (ubiquitin-like protein transferase activity), GO:0042802 (identical protein binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0042803 (protein homodimerization activity), GO:0003723 (RNA binding), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0009628 (response to abiotic stimulus), GO:0051651 (maintenance of location in cell), GO:0051051 (negative regulation of transport), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0051235 (maintenance of location), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0010942 (positive regulation of cell death), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0009314 (response to radiation), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0051224 (negative regulation of protein transport), GO:0032507 (maintenance of protein location in cell), GO:0043170 (macromolecule metabolic process), GO:0060249 (anatomical structure homeostasis), GO:0104004 (cellular response to environmental stimulus), GO:0010941 (regulation of cell death), GO:0071214 (cellular response to abiotic stimulus), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0001894 (tissue homeostasis), GO:0045185 (maintenance of protein location), GO:0032387 (negative regulation of intracellular transport), GO:0071478 (cellular response to radiation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0070201 (regulation of establishment of protein localization), GO:0072595 (maintenance of protein localization in organelle), GO:0032880 (regulation of protein localization), GO:0046823 (negative regulation of nucleocytoplasmic transport), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0008104 (protein localization), GO:0090317 (negative regulation of intracellular protein transport), GO:1904950 (negative regulation of establishment of protein localization), GO:0010212 (response to ionizing radiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0032386 (regulation of intracellular transport), GO:0043065 (positive regulation of apoptotic process), GO:0033365 (protein localization to organelle), GO:0042981 (regulation of apoptotic process), GO:0051457 (maintenance of protein location in nucleus), GO:0071479 (cellular response to ionizing radiation), GO:0043066 (negative regulation of apoptotic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0033157 (regulation of intracellular protein transport), GO:0019220 (regulation of phosphate metabolic process), GO:0046822 (regulation of nucleocytoplasmic transport), GO:0042325 (regulation of phosphorylation), GO:0034504 (protein localization to nucleus), GO:0046825 (regulation of protein export from nucleus), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140535 (intracellular protein-containing complex), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0099080 (supramolecular complex), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:1990234 (transferase complex), GO:0000152 (nuclear ubiquitin ligase complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0035770 (ribonucleoprotein granule), GO:0043233 (organelle lumen), GO:0000151 (ubiquitin ligase complex), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)