wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Dynactin subunit 5 (Q54XU5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Sequence: MQVQPKYFEKSQYIETLNGNKVSKSSILCGIMNIRLHGKTIIKPGVIVRGDLASVNIGRLSIISENTVIRPSSKKFKGSLVYFPQNIGDHVLVGEGCVISAASIGSNVYIGNNCIISKRCILKDCCIIADNTILPPDTVVPPFTYYSGTPGVYKEDLPDCIEQFQKEYTTSLYESFLPNTPASKGLPSTPTKLQTTTT
InterPro domains: - IPR011004: Trimeric LpxA-like superfamily (homologous_superfamily) [10-176]
- IPR047125: Dynactin subunit 5 (family) [1-180]
Interaction partners: - Dynactin subunit 4
- Dynactin subunit 6
- Dynactin subunit 2
- Dynactin 150 kDa subunit
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
- Cytoplasmic dynein 1 light intermediate chain 1
- Uncharacterized protein
- Actin-related protein 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0070840 (dynein complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0000003 (reproduction), GO:0051234 (establishment of localization), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0007276 (gamete generation), GO:0046907 (intracellular transport), GO:0007283 (spermatogenesis), GO:0006810 (transport), GO:0010970 (transport along microtubule), GO:0048232 (male gamete generation), GO:0099111 (microtubule-based transport), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0008088 (axo-dendritic transport), GO:0098930 (axonal transport), GO:0008090 (retrograde axonal transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005869 (dynactin complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: D-galactonate dehydratase family member EGBG_01401 (C8ZZN2)
Organism: Enterococcus gallinarum (strain EG2)
Function: Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Sequence: MTPTIITDVKSFAIKPDRHNLVVVKVETNKGISGLGCSTFQFRPLAVKTVVDEYLRPLLMGRDANEIEDIWQVMNVNSYWRNGPITNNAISGIDMALWDIKGQLADMPLYQLLGGKARTAIPAYTHAVADNLDDLYHEIDRFLAAGYRYIRCQLGFYGGNPSQLQTPEEPISGSYFDQTDYMETTLKMFAAIKEKYGNQFQMLHDVHERLHPNQAIQFAKAAEPYQLFFLEDILPPDQSHWLTQLRSQSATPIATGELFNNPMEWQELVKNRQIDFMRAHVSQIGGITPALKLAHFCDAMGVRIAWHTPSDISPVGLAVNTHLNIHLHNAAIQETIELPANTQSVFVGSPQPKGGFFYPMEKSGIGITFDEEAAADFPVVYRPHEWTQSRTPDGTLITP
InterPro domains: - IPR029065: Enolase C-terminal domain-like (domain) [181-373]
- IPR018110: Mandelate racemase/muconate lactonizing enzyme, conserved site (conserved_site) [89-114]
- IPR013341: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain (domain) [19-114]
- IPR013342: Mandelate racemase/muconate lactonizing enzyme, C-terminal (domain) [132-252]
- IPR029017: Enolase-like, N-terminal (homologous_superfamily) [7-384]
- IPR034593: D-galactonate dehydratase DgoD-like (family) [6-378]
- IPR036849: Enolase-like, C-terminal domain superfamily (homologous_superfamily) [102-379]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009274 (peptidoglycan-based cell wall)
Protein: C2H2-type domain-containing protein (Q8BLA2)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MVTHDTMSVFCPGTRLPQHPRGYSTEKPYKCEECGKAFRRASHLSQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYTCKECGKAFTQSSQLILHHRIHTGEKPYKCEACGKAFIRSSQLSRHQKVHTGEEPFECKECGKAFTQNSQLTLHQRLHTGEKLYDCKECRKVFTQLSQLILHRRIHTGEKPYECNECGKAFICGSQLSQHRKIHNGEKPYECKECGKAFIRGSLLMQHQRIHTGEKPYKCDECGKAFIRGSQLTQHQRVHTNEKPYECKECGKTFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYKCKECGKNFSRGSELTQHERIHTGEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCSECGKAFARGLLLIQHQRIHTGEKPYQCRECGKAFIRSSQLTQHQRTHTGEKPYECRECGKAFGHGSQLTLHQRVHTGEKPYECKECRKAFTQSSHLSRHQRVHTGEKPYQCKECEKAFTRESQLMRHQRIHIRGKSLDCKECRIDFNHHSQIFI
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [29-560]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [27-555]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071684 (organism emergence from protective structure), GO:0007275 (multicellular organism development), GO:0001824 (blastocyst development), GO:0009790 (embryo development), GO:0035188 (hatching), GO:0009792 (embryo development ending in birth or egg hatching), GO:0001835 (blastocyst hatching), GO:0043009 (chordate embryonic development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Plasma membrane intrinsic protein 1B (A8MRW1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MEGKEEDVRVGANKFPERQPIGTSAQSDKDYKEPPPAPLFEPGELASWSFWRAGIAEFIATFLFLYITVLTVMGVKRSPNMCASVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLARKLSLTRAVYYIVMQCLGAICGAGVVKGFQPKQYQALGGGANTIAHGYTKGSGLGAEIIGTFVLVYTVFSATDAKRNARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDNAWDDHVMGLLGWTIHWCCTCCSLPRYSHQSHPIQVQKLKLIEFYLKSGFCS
InterPro domains: - IPR000425: Major intrinsic protein (family) [44-261]
- IPR034294: Aquaporin transporter (family) [12-264]
- IPR022357: Major intrinsic protein, conserved site (conserved_site) [112-120]
- IPR023271: Aquaporin-like (homologous_superfamily) [37-273]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015267 (channel activity), GO:0005372 (water transmembrane transporter activity), GO:0015250 (water channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0010033 (response to organic substance), GO:0006810 (transport), GO:1902074 (response to salt), GO:0071702 (organic substance transport), GO:0042044 (fluid transport), GO:0006833 (water transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Chorismate mutase (CM) (EC 5.4.99.5) (TpARO7) (A0A0S0FTT9)
Organism: Trichoderma parareesei (Filamentous fungus)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P32178}.
Sequence: MDSAVDMADSERALNLTHIRFQLIRLEDTITFHLIERVQFPYNKTIYTPGAISIPDSKLSFFDWYFFQQEKLQSLIRRFESPDEYPYFPEAVQKPILKPLNYPKILHNNTVCVNDKIKKFYIEKFLPKVCPDFGREDRGEAQENYGSTSTCDIACLQALSRRIHFGKFVAESKFQSDPEYYTKLIQAEDREAIGESITNAAVEKQVLDRLRLKVETYGKDPSLLEGVEQPIKINVDAVVSMYKDFVIPLTKEVEVEYLMQRLIPEE
InterPro domains: - IPR037039: Chorismate mutase, AroQ class superfamily, eukaryotic (homologous_superfamily) [7-264]
- IPR036263: Chorismate mutase type II superfamily (homologous_superfamily) [6-262]
- IPR008238: Chorismate mutase, AroQ class, eukaryotic type (family) [1-263]
- IPR002701: Chorismate mutase II, prokaryotic-type (domain) [146-254]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0039694 (viral RNA genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0039689 (negative stranded viral RNA replication), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033655 (host cell cytoplasm part), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0044165 (host cell endoplasmic reticulum), GO:0042025 (host cell nucleus)
Protein: Dynein axonemal assembly factor 3 (F1Q7Z7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
Subcellular location: Cytoplasm {ECO:0000250}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q32NQ7}.
Sequence: MSAGRTFEGAGCVTWWGFGPARDLLNSDTHKVRLQEELNVLLVGSGDPRHILKTITGLTHSDTLHVWVIENSMEVIARQLLLLYISLLPPDKMSVHKKTEVFLEVFGNLEIRKETEESVKKAAAQLSISITYSLSSDSLSHSCLDTSLLKFKERDELVRIFKLWERPPSAPASVSKVWDARVRQHLGSRYDSRQGAFDWDLNMKLHQRGCGVINKHQYAKWRETGVTFEMREGLYQTANQSLLSTRVFNHRGNGVALRGYWGDIVSSPYLSFGIETENKELLKTQNNHYVKTAQDISEVNLLELFECLAARGRSPLNEDPPNTSSSCCQSTESRKTEENSQSDPSASQTQPVEHSPTQELDLLNVNGVKVSFLSPDSLSKLPLKSKYRNLFNTIFCSASMVHQLDSALREIAAPDAALVIELATFLLDLSKEQVSGFAVKVKEIAEESGFTPAHDQNSDKYAVFTQKNN
InterPro domains: - IPR028235: Dynein assembly factor 3, C-terminal domain (domain) [144-453]
- IPR039304: Dynein assembly factor 3, axonemal (family) [1-467]
- IPR027974: Domain of unknown function DUF4470 (domain) [15-111]
Interaction partners: - Dynein axonemal assembly factor 4.
- Dynein axonemal assembly factor 11
- Zinc finger MYND domain-containing protein 10
- Dynein axonemal assembly factor 19
- Dynein axonemal assembly factor 1
- Sperm-associated antigen 1A
- Dynein, axonemal, intermediate chain 1, paralog 1.
- Axonemal dynein light intermediate polypeptide 1
- Cilia- and flagella-associated protein 298
- PIH1 domain containing 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0009799 (specification of symmetry), GO:0048513 (animal organ development), GO:0003002 (regionalization), GO:0048731 (system development), GO:0009855 (determination of bilateral symmetry), GO:0060972 (left/right pattern formation), GO:0072359 (circulatory system development), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0043231 (intracellular membrane-bounded organelle), GO:0031514 (motile cilium), GO:0005634 (nucleus)
Protein: Cell wall integrity and stress response component 1 (P87179)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000269|PubMed:10759889}; Single-pass membrane protein {ECO:0000269|PubMed:10759889}.
Sequence: MVFLNSSPFKGRLLFFVYLLIISTRLVAADMNTQYGCYLVDSSLTEQGTFTYLDPAYCYNNICGGSDNIAFVAIRNNQCYCGSTLTATEVSSSLCTTPCPGYGSLMCGGDLYWSVYLTGNGVLQTTVSSSSVSSTTSSSSSSSPSSSSTTTTTSPSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSVPITSSTSSSHSSSSSSSSSSSSSSRPSSSSSFITTMSSSTFISTVTVTPSSSSSSTSSEVPSSTAALALNASKASNHTSLNAGAIVGIVIGCVAFAVVMALCIFLYFYFRRFKIRMSDSANEGKYPSYASELDSRLDPAMMNRKSSESLADSQDYSRKILRVTNLN
InterPro domains: - IPR002889: Carbohydrate-binding WSC (domain) [31-119]
- IPR051836: Kremen receptor (family) [36-273]
Interaction partners: - Rho1 guanine nucleotide exchange factor 2
- Rho1 guanine nucleotide exchange factor 1
- GTP-binding protein rho1
- Protein kinase C-like 2
- MAP kinase kinase skh1/pek1
- Uncharacterized aminotransferase C6B12.04c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0035556 (intracellular signal transduction), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0030242 (autophagy of peroxisome), GO:0007264 (small GTPase mediated signal transduction), GO:0007265 (Ras protein signal transduction), GO:0007266 (Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030427 (site of polarized growth), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0060187 (cell pole), GO:0098590 (plasma membrane region), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043332 (mating projection tip), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031520 (plasma membrane of cell tip), GO:0043231 (intracellular membrane-bounded organelle), GO:0005937 (mating projection)
Protein: Exocyst subunit Exo70 family protein (Q9C8H6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MAESKRLERLKAMRSLLKSEMEKSETFSLVLNKTGSKIEEINHKLSSLEADLKVERWKASPFSDHIRHTIAPISAVLRVFATVQELERSLVSSDGVLGYVSDVKRLGEAMKLLSSSCVLALNWLEDTIEYLTEKGMPEDHPCGLRFKTSIELLRELQMTESRAYLKGGILYTALKNLETEFKRILQEKPVFSEDNLRKLQAIIKRLHAHTRLTSCVPVYIKVRTKVIQKRFEISYLEKTITEADNVHDIEGDIDQWRLHMEIAVKEIYEFESKLCYDVFEDIGEDVPLRCFGEIASNSVILQLLRFGSRISKCKREPPKLIKLLDCFSTMDNFRIEFNRLFRGEQCSEIRRVTRELISNLVKGVSEIFWELPCQVELQRPNCPPLDGGVPKLVSVVTEYCNKLLGNNNKPILSKVLEIDLGWKNAKYQEELLTGHIYNILREIALNLDAWSSSNKETALSCIFMMNNHSHFCGLRETYLGEMMGESWLNAHEQYRDYYAALYVKESWGHLLSLLTNKAQTTSSSSSSSSESSPVKGKRARESIKRTLQAFCKGFDEIYTKQSNWVVEDDKLVWKICQAMVKTVVPRYKSYLQSYIKLLVEEDPTSDSKHLYYTPKGLEMKLKTMFQKKEETEKRDKDSHFVNKVMDLEITQNSRSTLEAI
InterPro domains: - IPR004140: Exocyst complex component Exo70 (family) [39-625]
- IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [76-625]
- IPR046364: Exocyst complex subunit Exo70, C-terminal (domain) [255-622]
Interaction partners: - Exocyst complex component EXO84C
- Exocyst complex component SEC8
- Exocyst complex component SEC6
- Exocyst complex component SEC5A
- Exocyst complex component SEC5B
- Exocyst complex component SEC3B
- Exocyst complex component SEC3A
- Exocyst complex component EXO84A
- Exocyst complex component SEC15B
- Exocyst complex component EXO84B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Lutropin subunit beta (Luteinizing hormone subunit beta) (LH-B) (LSH-B) (LSH-beta) (Lutropin beta chain) (P04651)
Organism: Bos taurus (Bovine)
Function: Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
Subcellular location: Secreted.
Sequence: MEMFQGLLLWLLLGVAGVWASRGPLRPLCQPINATLAAEKEACPVCITFTTSICAGYCPSMKRVLPVILPPMPQRVCTYHELRFASVRLPGCPPGVDPMVSFPVALSCHCGPCRLSSTDCGGPRTQPLACDHPPLPDILFL
InterPro domains: - IPR006208: Glycoprotein hormone subunit beta (domain) [27-130]
- IPR018245: Gonadotropin, beta subunit, conserved site (conserved_site) [54-130]
- IPR001545: Gonadotropin, beta subunit (family) [1-133]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [21-131]
Interaction partners: - Glycoprotein hormones alpha chain
- Lutropin-choriogonadotropic hormone receptor
- Carbohydrate sulfotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0046660 (female sex differentiation), GO:1901360 (organic cyclic compound metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048608 (reproductive structure development), GO:0001541 (ovarian follicle development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0061458 (reproductive system development), GO:0046545 (development of primary female sexual characteristics), GO:0008406 (gonad development), GO:0008585 (female gonad development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)