Protein: MFS-type transporter patC (Patulin biosynthesis cluster protein C) (A0A075TRA9)
Organism: Penicillium expansum (Blue mold rot fungus)
Function: MFS-type transporter; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria. May be involved in the secretion of E-ascladiol to be converted to patulin by the secreted patulin synthase patE (Probable).
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:30680886}; Multi-pass membrane protein {ECO:0000269|PubMed:30680886}. Cell membrane {ECO:0000269|PubMed:30680886}; Multi-pass membrane protein {ECO:0000269|PubMed:30680886}.
Sequence: MSIDASPSESVLESQTPDRVDESIPIKAEETEKDAAPGRDIVGFRWLLVCIAVFSANLLYGLDNTIVADIQAPIAGDFNEYTRLGWLGVGFTLGSVVFILPLGKAYAIFDTKWLFLGCLTMFAAGSALCGAAPSMNAIIVGRVWAGAGGAGMYLGNLNLITILTTPKEQPVYVGLVGLIYGTGCILGPIIGGAFSDSSATWRWSFYLNLVIFGVMSPIYVFLLPSLPRPAGEGRSFFKKLVELDWVGTVLSAGMHISIILFIVFGGVEWSWTDGRNIALYVVSAVLTIAFVLSQYFCIGTTKQDRLFPGEFLRDPTMLLLYIIMACGGAALFVAVYYIPLYFQFVHGDSGIMSAVRLLPFVCFYVATILLCGYVMPKTGYFIIWYLMSGVFMLIGAVLMYTVKLDTSPSNVYGYSILMGLGMTTTQAAYAVGPAIVTPDRVAECLQFMNIGQGQSQLLGLAIASAIFQTKTLSGLTALLGDKGYSQVDIQSAVAGAQSTLMERLPPALKTAALKVIVSSISDVYVMAISAGALYVVASCLLPRRRF
InterPro domains: - IPR011701: Major facilitator superfamily (family) [54-438]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [29-539]
- IPR020846: Major facilitator superfamily domain (domain) [49-545]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0019534 (toxin transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0044249 (cellular biosynthetic process), GO:0009404 (toxin metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0030638 (polyketide metabolic process), GO:1901334 (lactone metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043385 (mycotoxin metabolic process), GO:0009403 (toxin biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0030639 (polyketide biosynthetic process), GO:0043386 (mycotoxin biosynthetic process), GO:1901336 (lactone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)