Protein: Adenine phosphoribosyltransferase 3 (EC 2.4.2.7) (Q9SUW2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May contribute to the recycling of adenine into adenylate nucleotides and the inactivation of cytokinins by phosphoribosylation. Possesses low activity toward adenine and cytokinins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12010467}.
Sequence: MSGNKEEEDPRIHGIKTKIRVVPDFPKKGIMFQDITTVLLDPKAFKDTIDLFVERYRDKNISVVAGIEARGFLFGPPIALAIGAKFVPLRKPKKLPGETIFEEYELEYGNDRLEMHIGAVEAGDRALVVDDLIATGGTLCAAINLLERVGAEVVECACVIELPELKGRQRLKGKPLCMLVEYR
InterPro domains: - IPR029057: Phosphoribosyltransferase-like (homologous_superfamily) [2-182]
- IPR005764: Adenine phosphoribosyl transferase (family) [15-182]
- IPR050120: Adenine phosphoribosyltransferase (family) [7-182]
- IPR000836: Phosphoribosyltransferase domain (domain) [40-173]
Interaction partners: - Adenine phosphoribosyltransferase 5
- AMP deaminase
- GMP synthase
- Guanylate kinase 1
- Guanylate kinase 3, chloroplastic
- Guanylate kinase 2
- Inosine triphosphate pyrophosphatase
- Adenosine kinase 1
- Adenosine kinase 2
- Adenylosuccinate lyase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016763 (pentosyltransferase activity), GO:0106130 (purine phosphoribosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0043094 (cellular metabolic compound salvage), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009112 (nucleobase metabolic process), GO:0043101 (purine-containing compound salvage), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0072521 (purine-containing compound metabolic process), GO:0006144 (purine nucleobase metabolic process), GO:0046112 (nucleobase biosynthetic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009113 (purine nucleobase biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)