Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (Q9SFV7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
Sequence: MGALDEGCLNLELDIGMKNGCIELAFEHQPETLAIQDAVKLLLQGLHEDVNREGIKKTPFRVAKALREGTRGYKQKVKDYVQSALFPEAGLDEGVGQAGGVGGLVVVRDLDHYSYCESCLLPFHVKCHIGYVPSGQRVLGLSKFSRVTDVFAKRLQDPQRLADDICSALQHWVKPAGVAVVLECSHIHFPSLDLDSLNLSSHRGFVKLLVSSGSGVFEDESSNLWGEFQSFLMFKGVKTQALCRNGSSVKEWCPSVKSSSKLSPEVDPEMVSAVVSILKSLGEDPLRKELIATPTRFLKWMLNFQRTNLEMKLNSFNPAKVNGEVKEKRLHCELNMPFWSMCEHHLLPFYGVVHIGYFCAEGSNPNPVGSSLMKAIVHFYGFKLQVQERMTRQIAETLSPLVGGDVIVVAEAGHTCMISRGIEKFGSSTATIAVLGRFSSDNSARAMFLDKIHTTNALKTESSSPF
InterPro domains: - IPR043134: GTP cyclohydrolase I, N-terminal domain (homologous_superfamily) [27-310]
- IPR001474: GTP cyclohydrolase I (family) [30-187]
- IPR043133: GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase (homologous_superfamily) [99-455]
- IPR020602: GTP cyclohydrolase I domain (domain) [35-452]
Interaction partners: - Folate synthesis bifunctional protein
- Folate synthesis bifunctional protein
- Probable dihydroneopterin aldolase 3
- Dihydroneopterin aldolase 1
- Dihydroneopterin aldolase 2
- Protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5
- Folylpolyglutamate synthase
- Dihydrofolate synthetase
- Folylpolyglutamate synthase
- Folylpolyglutamate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0019238 (cyclohydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0042559 (pteridine-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)