Protein: DNA topoisomerase 2 (EC 5.6.2.2) (Q383C4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSGRTVEEIYQKKTQHEHILARPDMYIGTIEPVTEDVWVYDEADNVMKLRKCTWTPGLYKIFDEILVNAADNKVRDPHGQTTIKVWVDAARGLVRVYNNGEGIPVQRHREHDLWVPEMIFGHLLTSSNYDDTEAKVTGGRNGFGAKLTNVFSTRFEVETVHSRSRKKFFMRWRNNMLENEEAVITPCDGPDYTVVTFYPDFEKFNLEGFTEDMVLIMQRRVYDIAGCTDKSLCCYLNDTRIACRSFPEYVDLYPTMGEERKPSSYSRVNDRWEVCVRVSNVGFQQVSFVNSIATTRGGTHVKYIVDQIIAKVTDQAMRKSKTEVKPHMIRPHLFIFVNSLIENPSFDSQTKETLNTPKARFGSTCDLPASLIDCVLKSSIVERAVEMANSRLNREMAMKMRNTNRKQILGIPKLDDANEAGGKYSQRCTLILTEGDSAKALCTAGLAVENRDYFGVFPLRGKPLNVRDASVKKVMGCAEFQAVSKIMGLDLSQKYTSTEGLRYGHLMIMSDQDHDGSHIKGLIINMIHNYWPDLLKVPGFLQQFITPIVKARKKGRGNNDEGTISFFSMPDYFEWKNAVGEGIKNYELRYYKGLGTSGAKEGREYFENIDRHRLNFVYEDRKDDDDIVMAFAKDKVDERKRWITEFKANTNINESMNYNVRNVSYSEFVHKELILFSVADCERSIPSVVDGLKPGQRKIMFSAFKRNLVRSLKVAQLAGYVSEHAAYHHGEQSLVQTIVGLAQDYVGANNVPLLYRDGQFGTRLQGGKDHAAGRYIFTRLTDIARRIYHPSDDFIVEYRDDDGLSVEPFYYVPVIPMVLVNGTAGIGTGFATNIPNYSPLDVIDNLNRLLSGEELQPMKPWYFGFTGTIEEREKGKFVSSGCATVRPDGVVHITELPIGTWTQQYKKFLEDLREREIVIQYREHNTDVTVDFEVFIHPEVLRQWVAQGCVEERLQLREYIHATNIIAFDREGKITKYLDAESVLKEFYLVRLEYYARRREFLLEQLQRAALKLENMVRFVNEVIDGTFIVTRRSMKDVLKDLKQRGYTPFPPQQKKKMSSTTIVDEEDNDGARKILPDVFEFESVPLCEQVIGKILCTAEPEEINMWKGVLVEYDYLLSLRMVDLTVEMAMYFRTKREQMLNKHNFVLSASSKDLWREDLDLLRSDIEKLFDERRREIALIQCKKLEKRQFFDVSRLRVPLLSDAARKADRSLALRQSNCKREMSSKCASESFALLVDAGVRVSGLTEGSSICDINEARRKYGHSVAGGKRRLVRHDEVSKRGKFSSCGDQRHVSLSDGSDTDDCSIGAPSVSPSDATPATQKSRKISDSSYGFGIEGEVDIFFEDTVGEDFSEPATQANIVRSKSESPVLDFSAEYATEPKSRKRPRSIEDNDENTCPFYVDVVGEDVEYDSDQCIGFDACVF
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [8-255]
- IPR013758: DNA topoisomerase, type IIA, domain A, alpha-beta (homologous_superfamily) [685-977]
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [264-390]
- IPR013760: DNA topoisomerase, type IIA-like domain superfamily (homologous_superfamily) [405-1178]
- IPR001154: DNA topoisomerase II, eukaryotic-type (family) [413-998]
- IPR013757: DNA topoisomerase, type IIA, alpha-helical domain superfamily (homologous_superfamily) [980-1177]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [57-156]
- IPR034157: DNA topoisomerase 2, TOPRIM domain (domain) [428-546]
- IPR013759: DNA topoisomerase, type IIA, subunit B, C-terminal (homologous_superfamily) [414-684]
- IPR002205: DNA topoisomerase, type IIA, domain A (domain) [663-1161]
- IPR013506: DNA topoisomerase, type IIA, subunit B, domain 2 (domain) [268-395]
- IPR031660: C-terminal associated domain of TOPRIM (domain) [544-681]
- IPR050634: DNA Topoisomerase II (family) [4-1203]
- IPR018522: DNA topoisomerase, type IIA, conserved site (conserved_site) [432-440]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [234-388]
- IPR006171: TOPRIM domain (domain) [428-542]
- IPR001241: DNA topoisomerase, type IIA (family) [57-648]
Interaction partners: - Structural maintenance of chromosomes protein
- Small ubiquitin protein, putative
- Bifunctional dihydrofolate reductase-thymidylate synthase
- SUMO-conjugating enzyme UBC9
- DNA topoisomerase I
- DNA topoisomerase type IB small subunit
- Structural maintenance of chromosomes protein
- DNA topoisomerase
- Ubiquitin-conjugating enzyme E2, putative
- Proliferating cell nuclear antigen
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016853 (isomerase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0005515 (protein binding), GO:0003916 (DNA topoisomerase activity), GO:0140097 (catalytic activity, acting on DNA), GO:0003918 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051301 (cell division), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006260 (DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0020023 (kinetoplast), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)