Protein: INO80 complex subunit 1 (Q9UTM0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm {ECO:0000269|PubMed:16823372}.
Sequence: MSISSDTSGSVPGSPIDLEPESETICHWQSCEQDLLTLDNLVHHIHNGTTSNLRLISNINSILDHIGNRRPKYTCEWDDCPRKGMVQTSRFALVAHLRSHTGEKPFICSVPECDRSFTRSDALAKHMRTVHEADTLRPSDPIPKAHPMHPQNVANAMVQSAREARAQQQMHGVGNTNEDVENWLDAASMPKTSHDMYRLQKRKLQWVKEERTMLANHLEALERKLIDARNRKEKILNEIVKQVDPSISR
InterPro domains: - IPR056436: ZIC1-5/GLI1-3like, C2H2 zinc finger (domain) [75-104]
- IPR013087: Zinc finger C2H2-type (domain) [73-136]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [90-132]
- IPR043359: C2H2-type zinc-finger protein GLI-like (family) [19-128]
Interaction partners: - Chromatin-remodeling complex subunit ies6
- INO80 complex subunit 3
- RuvB-like helicase 1
- Actin-like protein arp5
- Probable actin-related protein 8
- INO80 complex subunit 4
- INO80 complex subunit 5
- HMG box-containing protein C10F6.08c
- Actin
- Chromatin-remodeling ATPase INO80
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)