Protein: Perilipin-3 (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Q9DBG5)
Organism: Mus musculus (Mouse)
Function: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
Subcellular location: Lipid droplet {ECO:0000250|UniProtKB:O60664}. Endosome membrane {ECO:0000250|UniProtKB:O60664}; Peripheral membrane protein {ECO:0000250|UniProtKB:O60664}; Cytoplasmic side {ECO:0000250|UniProtKB:O60664}. Cytoplasm {ECO:0000250|UniProtKB:O60664}. Note=Membrane associated on endosomes. Detected in the envelope and the core of lipid bodies and in lipid sails. {ECO:0000250|UniProtKB:O60664}.
Sequence: MSSNGTDAPAEAQAAMEEPVVQPSVVDRVAGLPLISSTYGMVSAAYTSTKENYPHVRTVCDVAEKGVKTLTTAAVSTAQPILSKLEPQIATASEYAHRGLDRLQESLPILQQPTEKVLADTKELVSSTVSGAQEMVSSSVSSAKETVATRVTGAVDVTLGAVQNSVDKTKSAMTSGVQSVMGSRVGQMVISGVDRVLVKSEAWADNRLPLTEAELALIATPPEDSDMASLQQQRQEQNYFVRLGSLSERLRNHAYEHSLGKLQNARQKAQETLQQLTSVLGLMESVKQGVDQRLGEGQEKLHQMWLSWNQKTPQDAEKDPAKPEQVEARALSMFRDITQQLQSMCVALGASIQGLPSHVREQAQQARSQVNDLQATFSGIHSFQDLSAGVLAQTRERIARAREALDNTVEYVAQNTPAMWLVGPFAPGITEKTPEGK
InterPro domains: - IPR004279: Perilipin (family) [1-437]
Interaction partners: - Heat shock cognate 71 kDa protein
- Cation-independent mannose-6-phosphate receptor
- 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
- Hormone-sensitive lipase
- Rab9 effector protein with kelch motifs
- Vesicle-associated membrane protein 3
- Rho-related BTB domain-containing protein 3
- Ras-related protein Rab-18
- Cation-dependent mannose-6-phosphate receptor
- Patatin-like phospholipase domain-containing protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:1905954 (positive regulation of lipid localization), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0051235 (maintenance of location), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0045833 (negative regulation of lipid metabolic process), GO:0051646 (mitochondrion localization), GO:1905952 (regulation of lipid localization), GO:0044092 (negative regulation of molecular function), GO:0009966 (regulation of signal transduction), GO:0010883 (regulation of lipid storage), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010876 (lipid localization), GO:0009894 (regulation of catabolic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0019915 (lipid storage), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0062014 (negative regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010884 (positive regulation of lipid storage), GO:0045834 (positive regulation of lipid metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0050996 (positive regulation of lipid catabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0010565 (regulation of cellular ketone metabolic process), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0090209 (negative regulation of triglyceride metabolic process), GO:0051336 (regulation of hydrolase activity), GO:2000378 (negative regulation of reactive oxygen species metabolic process), GO:0031330 (negative regulation of cellular catabolic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0090208 (positive regulation of triglyceride metabolic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0050995 (negative regulation of lipid catabolic process), GO:0045922 (negative regulation of fatty acid metabolic process), GO:0010889 (regulation of sequestering of triglyceride), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0090207 (regulation of triglyceride metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0050994 (regulation of lipid catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0006996 (organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0032000 (positive regulation of fatty acid beta-oxidation), GO:0051346 (negative regulation of hydrolase activity), GO:0010896 (regulation of triglyceride catabolic process), GO:0031998 (regulation of fatty acid beta-oxidation), GO:0046321 (positive regulation of fatty acid oxidation), GO:0046322 (negative regulation of fatty acid oxidation), GO:0034389 (lipid droplet organization), GO:0060191 (regulation of lipase activity), GO:0010866 (regulation of triglyceride biosynthetic process), GO:0010867 (positive regulation of triglyceride biosynthetic process), GO:0019217 (regulation of fatty acid metabolic process), GO:0060192 (negative regulation of lipase activity), GO:0046320 (regulation of fatty acid oxidation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)