wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Importin subunit alpha (Q7ZVY9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
Sequence: MSDSEKLDKQRLKNFKNKGRDLETMRRQRTEVVVELRKNKRDEHLLKRRNVPHEDICDDSDADGDFRSQNTSLEAIVQNATSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLDRDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPYLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALGHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIILLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQQVIPPFCNLLTVKDAQVVQVVLDGLSNILKMADDEAETVANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDSNLVPEAIQGGTYSFNSSTNVPAEGFQF
InterPro domains: - IPR002652: Importin-alpha, importin-beta-binding domain (domain) [1-93]
- IPR016024: Armadillo-type fold (homologous_superfamily) [8-486]
- IPR011989: Armadillo-like helical (homologous_superfamily) [68-487]
- IPR036975: Importin-alpha, importin-beta-binding domain superfamily (homologous_superfamily) [10-51]
- IPR024931: Importin subunit alpha (family) [3-521]
- IPR000225: Armadillo (repeat) [103-440]
- IPR032413: Atypical Arm repeat (repeat) [448-499]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Extracellular superoxide dismutase [Cu-Zn] (A5PLA4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen
Subcellular location: Golgi apparatus, trans-Golgi network. Secreted, extracellular space
Sequence: MKKLISVILLALHIQRGDFSDNSDFHLIEAPKLEVFEFNNTIYATCEVSPIPNLPAGQPKIFGQVLFRQVFPNGTAEVKINLRGFPETDNQVRAIHIHQYGDLSQGCVTAGPHYNPQDVPHPNHPGDMGNFMPKQGLIRRFLKLPEVKLFGGQSVLGRAVVVHEKEDDLGMGADEESKRSGNAGRRIAGCVIGITKPHLWQKTEHVEEEESKR
InterPro domains: - IPR024134: Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone (family) [44-208]
- IPR036423: Superoxide dismutase-like, copper/zinc binding domain superfamily (homologous_superfamily) [40-204]
- IPR018152: Superoxide dismutase, copper/zinc, binding site (binding_site) [94-104]
- IPR001424: Superoxide dismutase, copper/zinc binding domain (domain) [56-193]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004784 (superoxide dismutase activity), GO:0016491 (oxidoreductase activity), GO:0016721 (oxidoreductase activity, acting on superoxide radicals as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0071466 (cellular response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: N-sulfoglucosamine sulfohydrolase (sulfamidase) (B0V3V9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MAFVFAWTLLCLLLCFDVGGCRSRNVLLIIADDGGFETDVYNNTVVQTPHLRALSKRSLIFKNAFTSVSSCSPSRSTILTGLPQHQNGMYGLHQGVHHFNSFDGVQSLPLLLKRANIHTGIIGKKHVGPGPVYPFDFAYTEETNSVLQVGRNITKIKLLVRKFFQSHKEERSETKEERPFFLYVAFHDPHRCGHSQPQYGVFCEKFGNGESGMGRIPDWEPKYYSPDQVKVPYFIPDTPAARADIAAQYTTVSRLDQGIGLVLEELRKAGFENDTLVIYSSDNGIPFPNGRTNLYGSGVKEPMLLSSPEHQQRWGKLSQAYVSLLDITPTILDWFSLPYPSYSLSMSQPVELTGRSLLPALISEPSWDTVFSSQSLHEVTMFYPMRSIHKGPYRLLHNLHYRMPFPIDQDFYISPTFQDLLNRTQSGRPTGWFKTLNEYYYRQRWELFDVRTDPMEKVNLAGDLDYSEVLESLKDLLLKWQWRTEDPWVCEPDAVLEAKLEPECRPLYNGL
InterPro domains: - IPR024607: Sulfatase, conserved site (conserved_site) [69-81]
- IPR000917: Sulfatase, N-terminal (domain) [24-335]
- IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [23-506]
Interaction partners: - Heparan-alpha-glucosaminide N-acetyltransferase
- Alpha-L-iduronidase
- Si:dkey-192p21.6
- Alpha-N-acetylglucosaminidase
- N-acetylglucosamine-6-sulfatase
- AP complex subunit sigma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0009057 (macromolecule catabolic process), GO:0044273 (sulfur compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009100 (glycoprotein metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0006029 (proteoglycan metabolic process), GO:0006516 (glycoprotein catabolic process), GO:0030167 (proteoglycan catabolic process), GO:0030201 (heparan sulfate proteoglycan metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0005764 (lysosome), GO:0043202 (lysosomal lumen)
Protein: Formylglycine-generating enzyme (F1QHA4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE
Subcellular location: Endoplasmic reticulum lumen
Sequence: MAMAPVLNICVVLFFSILAVSCDVGDIVQEQRSESPESQGTDCGCQGLKREVSVGVSDVNTLDHHDDANIYSKTANEGPDKTESDVRSKLVLLQGGWFLMGTDDPGIPQDGEGPQRKVKLDAFYIEEHEVTNQQFQHFTNQTGYITEAERFGDSFVFEGLLSEEVKSTLSHAVAAAPWWSPVKGADWRHPEGPDSTIHNRMNHPALHVSWDDARAYCQWAKRRLPTEAEWELACRGGLQDRMYPWGNKLMPRGQHYANLWQGDFPNHNTAEDGYANTSPVMSFPANGFGLYDMVGNAWEWTADWWTVHHSAEDKFNPKGPESGTDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCASDVDP
InterPro domains: - IPR051043: Sulfatase Modifying Factor and Kinase (family) [77-368]
- IPR042095: Sulfatase-modifying factor enzyme superfamily (homologous_superfamily) [74-369]
- IPR005532: Sulfatase-modifying factor enzyme-like domain (domain) [89-365]
- IPR016187: C-type lectin fold (homologous_superfamily) [89-368]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0016670 (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043687 (post-translational protein modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: non-specific serine/threonine protein kinase (Q7ZTX0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, cilium. Cytoplasm, cytoskeleton. Nucleus
Sequence: MNRYTTLKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFVFEYMKENLYQLMKDRENKMFTENEIRNIMFQVLSGLAFVHKHGFFHRDMKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSPVYSSPIDIWAVGCIMAELYTLRPLFPGNSEVDEIFKICQVLGTVKKSDWPEGHQLASAMNFRFPQCVPTPLKTLIPNATNEALDIMRDLLQWDPKKRPSAVKALRYPYFQVGQLLGPRPMTPDVRKAPVKAVLPSELRSEMQSVSEPVLPSQTKGQSRNSHQPLQQIPLPQSLTQTDTVALHTQKVVGGENSLMGLKNGRRRWGQTNMKPSDSWDDSDCSDTAASLSKKPSKGPEEEKTTPQPKEQKPLYTFSTVTKLPNTSRLNQSDSSHQSTSSARQHYLRQSRYMPGLISKNTQSLSSKESQQDFWDTSALMSKPLAPIGGAPMSRISPGNFVTTTYNLSGGYIPSFQKKEVGSVGQRIQLAPLGHQHALDLSATADCKTGKAKPSKSKPSSTVSVNDNSEDYDGWKRRAERTQLKGTSYSALGKNSANLITHAPSVQPVHGRIDWAAKYGSHR
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [122-134]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1-286]
- IPR017441: Protein kinase, ATP binding site (binding_site) [10-33]
- IPR000719: Protein kinase domain (domain) [4-285]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [3-353]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0044087 (regulation of cellular component biogenesis), GO:0031344 (regulation of cell projection organization), GO:1902115 (regulation of organelle assembly), GO:0033043 (regulation of organelle organization), GO:0060491 (regulation of cell projection assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1902017 (regulation of cilium assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)
Protein: Large ribosomal subunit protein uL3 (A0A2R8Q924)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm. Nucleus, nucleolus
Sequence: MSHRKFSAPRHGSLGFLPRKRCKRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTVVETPPMIVVGVVGYVMTPRGLRSFKTIFAEHISDECKRRFYKNWYKSKKKAFTKYCKRWQDEEGKKQLEKDFSSMKKYCQIIRIIAHTQMRLLPHRQKKSHLMEIQLNGGTISDKVDWAREKLEQSIPIANVFSQDEMIDVIGVTKGHGCKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGVGYHNKDGKLVKNNASTDYDLSNKSINPLGGFVHYGEVTNDFLMLKGCVVGTKKRVLTLRKSLLVQTSRRAQEKIDLKFIDTTSKFGHGRFQTIEEKKNFMGPLKKDRLAKEEMA
InterPro domains: - IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [4-375]
- IPR044892: Ribosomal protein L3, domain 3, archaeal-type superfamily (homologous_superfamily) [1-273]
- IPR019926: Large ribosomal subunit protein uL3, conserved site (conserved_site) [211-234]
- IPR000597: Large ribosomal subunit protein uL3 (family) [1-375]
- IPR045077: Large ribosomal subunit protein uL3, archaea/eukaryota (family) [1-393]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0055123 (digestive system development), GO:0031016 (pancreas development), GO:0031017 (exocrine pancreas development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: hypoxia-inducible factor-proline dioxygenase (Q6NY85)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MPFLQHDLDTQLESLAFAQVVPALLDQGFFYVDHFLGDIAGHMVLGQVKRMHSCGLLNDGQLAGQSSGVCRRNIRGDKITWVNGTERGTEAVNFLLTLIDKLISLCVGRLGKSIRARSKAMVACYPGNGAGYVKHVDNPNADGRCVTCIYYLNKNWNAKEHGGLLRIFPEGKPYVADIEPLFDRLLLFWSDRRNPHEVQPSYATRYAITVWYFDSEERAEAKRKYLTAISQEGSSS
InterPro domains: - IPR051559: Hypoxia-inducible factor prolyl hydroxylases (family) [11-228]
- IPR006620: Prolyl 4-hydroxylase, alpha subunit (domain) [27-213]
- IPR005123: Oxoglutarate/iron-dependent dioxygenase domain (domain) [112-214]
- IPR044862: Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain (domain) [121-212]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0031543 (peptidyl-proline dioxygenase activity), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048736 (appendage development), GO:0009790 (embryo development), GO:0035107 (appendage morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0033333 (fin development), GO:0060173 (limb development), GO:0033334 (fin morphogenesis), GO:0035113 (embryonic appendage morphogenesis), GO:0035118 (embryonic pectoral fin morphogenesis), GO:0033339 (pectoral fin development), GO:0035138 (pectoral fin morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0005634 (nucleus)
Protein: Tyrosyl-DNA phosphodiesterase 1 (F8W5U2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate
Subcellular location: Cytoplasm. Nucleus
Sequence: MSQDSQHGKWSISDSEDEDIIPPTPQKDSVKPIVKPDSQSKPEETPTFLKQEPRLSPKRNENSVKTASAPSMGSEARKSAHVNQANPVKYERNASPAVKRKRETEEGGWNLSSSDDETPAPRNEPQKVNISPKRKKKTEDKRPPSPHGTSYYKEEPADFFETNLMPTNDIYRFYLNKVTGIPKKYNTGALHIKEILSPMFGTLKESVQFNYCFDIPWMVEQYPPEFRNKPVVLVHGEKRESKACLIEQAKPYPHISFCQAKLDIAFGTHHTKMMLLWYEEGFRVIILTSNLIRADWYQKTQGMWMSPLYPRLPQGSPGTAGESLTGFKRDLLEYLEAYRAPELANWIERIKQHDLSETRVYLIGSTPGRYQGPAMEKWGHLRLRKLLSEHTQPMQNEERWHVLGQFSSIGSMGLDKTKWLAAEFQRTLTTLGKAGKSLASPETQMLLIYPSVENVRTSLEGYPAGGSLPYSIQTAQKQLWLHSYFHGWHADVTGRSNAMPHIKTYMRISPDFTQLAWFLVTSANLSKAAWGALEKNNTQIMVRSYELGVLYLPSAFNMSTFPVEKNVFPACSSSIGFPVPFDLPPQRYSSKDRPWIWNIPYTQAPDTHGNVWVPS
InterPro domains: - IPR010347: Tyrosyl-DNA phosphodiesterase I (family) [31-612]
Interaction partners: - Tyrosyl-DNA phosphodiesterase 2
- Aprataxin
- DNA repair protein XRCC1
- Bifunctional polynucleotide phosphatase/kinase
- DNA ligase
- DNA helicase
- DNA ligase
- Structure-specific endonuclease subunit MUS81
- DNA polymerase beta
- N-glycosylase/DNA lyase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Large ribosomal subunit protein eL22 (F1QG80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm
Sequence: MRFFSSSFLPKLSAMAPIKKQVTKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVSIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANTKESYELRYFQINQDEEEEDED
InterPro domains: - IPR038526: Large ribosomal subunit protein eL22 superfamily (homologous_superfamily) [21-141]
- IPR002671: Large ribosomal subunit protein eL22 (family) [13-139]
Interaction partners: - Large ribosomal subunit protein eL33
- Large ribosomal subunit protein eL14
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL30
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein eL38
- Ribosomal protein L4
- Large ribosomal subunit protein eL21
- 40S ribosomal protein S6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)