Protein: Glutamate receptor (Q71E59)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system
Subcellular location: Postsynaptic cell membrane; Multi- pass membrane protein
Sequence: MRILVLIPLLWGLGEGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNATEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLVTPSFPAEGETQFVLQLRPSIRGALLSLLDHYDWSRFVFLYDTDRGYAVLQAIMEKAGQNGWQVSAICVENFNDASYRRLLEDLDRRQEKKFVIDLEAERLQNILEQIVSVGKHVKGYHYIVANLGFKDISLERFMHGGANVTGFQLVDFSKPMVIKLMQRWNKLDQREYPGSESPPRYTSSLTYDGVLVMAEAFRNLRRQKIDISRRGNAGDCLANPAAPWNQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVFELKSNGPRKIGYWNDLDKLVLVQNELSMGNDSAMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQFEGYCVDLASEVAKHIGIKYKISIVLDGKYGARDPETKIWNGMVGELVYGKAEIAVAPLAITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKSSQALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKKLKLTFSEAMRNKARLSITGSLGENGRVLTPDCPKAVHSGPSYRHGPALAVVSSDLP
InterPro domains: - IPR001508: Ionotropic glutamate receptor, metazoa (family) [454-834]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [410-524]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [410-821]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [16-386]
- IPR015683: Ionotropic glutamate receptor (family) [33-840]
- IPR001828: Receptor, ligand binding region (domain) [35-376]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0008066 (glutamate receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0007154 (cell communication), GO:0050794 (regulation of cellular process), GO:0099536 (synaptic signaling), GO:0050803 (regulation of synapse structure or activity), GO:0099536 (synaptic signaling), GO:0051128 (regulation of cellular component organization), GO:0009636 (response to toxic substance), GO:0099537 (trans-synaptic signaling), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission), GO:0035249 (synaptic transmission, glutamatergic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0005886 (plasma membrane), GO:0098878 (neurotransmitter receptor complex), GO:0034702 (ion channel complex), GO:0008328 (ionotropic glutamate receptor complex)