Protein: 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12) (Q03393)
Organism: Homo sapiens (Human)
Function: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
Sequence: MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE
InterPro domains: - IPR022470: 6-pyruvoyl tetrahydropterin synthase, cysteine active site (active_site) [43-53]
- IPR038418: 6-pyruvoyl tetrahydropterin synthase/QueD superfamily (homologous_superfamily) [6-145]
- IPR007115: 6-pyruvoyl tetrahydropterin synthase/QueD family (family) [8-145]
- IPR022469: 6-pyruvoyl tetrahydropterin synthase, histidine active site (active_site) [89-96]
Interaction partners: - GTP cyclohydrolase 1
- Sepiapterin reductase
- Receptor-type tyrosine-protein phosphatase alpha
- Tyrosine-protein phosphatase non-receptor type 12
- Tyrosine-protein phosphatase non-receptor type 7
- Carbonyl reductase 1])
- Aldo-keto reductase family 1 member B1
- Aldo-keto reductase family 1 member C3
- Alkaline phosphatase, placental type
- Alkaline phosphatase, tissue-nonspecific isozyme
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0042802 (identical protein binding), GO:0016835 (carbon-oxygen lyase activity), GO:0016838 (carbon-oxygen lyase activity, acting on phosphates)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019751 (polyol metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0042559 (pteridine-containing compound biosynthetic process), GO:0034311 (diol metabolic process), GO:0046173 (polyol biosynthetic process), GO:0034312 (diol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)