Protein: Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PsmB) (Q58634)
Organism: Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.jannaschii proteasome is able to cleave oligopeptides after Glu, Asp, Tyr, Phe, Trp, slightly after Arg, but not after Ala. Thus, displays caspase-like and chymotrypsin-like activities and low level of trypsin-like activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02113}.
Sequence: MDVMKGTTTVGLICDDAVILATDKRASLGNLVADKEAKKLYKIDDYIAMTIAGSVGDAQAIVRLLIAEAKLYKMRTGRNIPPLACATLLSNILHSSRMFPFLTQIIIGGYDLLEGAKLFSLDPLGGMNEEKTFTATGSGSPIAYGVLEAGYDRDMSVEEGIKLALNALKSAMERDTFSGNGISLAVITKDGVKIFEDEEIEKILDSMKAKPKKKTTKRSRRKSK
InterPro domains: - IPR023333: Proteasome B-type subunit (family) [4-193]
- IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [1-223]
- IPR001353: Proteasome, subunit alpha/beta (family) [4-187]
- IPR016050: Proteasome beta-type subunit, conserved site (conserved_site) [10-57]
- IPR019983: Peptidase T1A, proteasome beta-subunit, archaeal (family) [2-199]
- IPR000243: Peptidase T1A, proteasome beta-subunit (family) [14-184]
Interaction partners: - Proteasome subunit alpha
- Proteasome-activating nucleotidase
- Large ribosomal subunit protein eL40
- Tetrahydromethanopterin S-methyltransferase subunit A
- Cell division cycle protein 48 homolog MJ1156
- Uncharacterized protein MJ0106
- Transcription termination factor FttA
- Ribose 1,5-bisphosphate isomerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0019773 (proteasome core complex, alpha-subunit complex), GO:0140535 (intracellular protein-containing complex), GO:0005839 (proteasome core complex), GO:1905368 (peptidase complex), GO:0000502 (proteasome complex), GO:1905369 (endopeptidase complex)