Protein: Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) (P27615)
Organism: Rattus norvegicus (Rat)
Function: Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting.
Subcellular location: Lysosome membrane {ECO:0000269|PubMed:1715871, ECO:0000269|PubMed:1859403}; Multi-pass membrane protein {ECO:0000269|PubMed:1715871, ECO:0000269|PubMed:1859403}.
Sequence: MARCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQTIEKNMVLQNGTKVFDSWEKPPLPVYIQFYFFNVTNPEEILQGEIPLLEEVGPYTYRELRNKANVQFGENGTTISAVTNKAYIFERNQSVGDPTVDLIRTINIPLLTVVEMAQQPFLREIIEAMLKAYQQTLFVTHTVHELLWGYKDEVLSLVHIFRPDVSPNFGLFYERNGTNDGEYVFLTGEDNYLNFTKIVEWNGKTSLDWWTTDTCNMINGTDGDSFHPLISKDETLYIFPSDFCRSVYITFSSFENVEGLPAFRYKVPAEILANSSENAGFCIPEGNCMDAGVLNVSICKNGAPIIMSFPHFYQADEKFVSAIKGMRPNKEEHESFVDINPLTGIILRGAKRFQINTYVKKLDDFVETGNIRTMVFPVMYLNESVLIDKETASQLKSVINTTLIVTNIPYIIMALGVFFGLIFTWLACRGQGSTDEGTADERAPLIRT
InterPro domains: - IPR002159: CD36 family (family) [9-461]
- IPR005429: Lysosome membrane protein II (family) [3-477]
Interaction partners: - Thrombospondin-1
- Toll-like receptor 4
- Leukocyte surface antigen CD47
- Toll-like receptor 2
- Toll-like receptor
- CD63 antigen
- Apolipoprotein B-100
- Glucosylceramidase
- Thrombospondin-2
- Tyrosine-protein kinase Lyn
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038024 (cargo receptor activity), GO:0038023 (signaling receptor activity), GO:0005044 (scavenger receptor activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0019899 (enzyme binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0099637 (neurotransmitter receptor transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0060627 (regulation of vesicle-mediated transport), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0097120 (receptor localization to synapse), GO:0098969 (neurotransmitter receptor transport to postsynaptic membrane), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0017157 (regulation of exocytosis), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0098877 (neurotransmitter receptor transport to plasma membrane), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0033365 (protein localization to organelle), GO:1902414 (protein localization to cell junction), GO:0099003 (vesicle-mediated transport in synapse), GO:0072659 (protein localization to plasma membrane), GO:1903539 (protein localization to postsynaptic membrane), GO:1990778 (protein localization to cell periphery), GO:1903540 (establishment of protein localization to postsynaptic membrane), GO:0061951 (establishment of protein localization to plasma membrane), GO:0035418 (protein localization to synapse), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005774 (vacuolar membrane), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0030666 (endocytic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0098852 (lytic vacuole membrane), GO:0043202 (lysosomal lumen), GO:0005765 (lysosomal membrane)