Protein: Growth hormone-inducible transmembrane protein (Q91VC9)
Organism: Mus musculus (Mouse)
Function: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (By similarity)
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MLAARLVCLRTLPSRVFQPTFITKASPLVKNSITKNQWLVTPSREYATKTRIRTHRGKTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGMSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSALAVARTPALMNFMMTGSWVTIGATFAAMIGAGMLVHSISYEQSPGPKHLAWMLHSGVMGAVVAPLTILGGPLLLRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFASSLGSMFLPPTSVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEITPMYGAQKYDPINSMLTIYMDTLNIFMRVATMLATGSNRKK
InterPro domains: - IPR006214: Bax inhibitor 1-related (family) [114-338]
- IPR035871: Growth hormone-inducible transmembrane protein (domain) [82-345]
Interaction partners: - Cytochrome b-c1 complex subunit 2, mitochondrial
- Protein lifeguard 3
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
- Bax inhibitor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0044057 (regulation of system process), GO:1901215 (negative regulation of neuron death), GO:0090257 (regulation of muscle system process), GO:0034330 (cell junction organization), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0007600 (sensory perception), GO:0061024 (membrane organization), GO:0007005 (mitochondrion organization), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0007006 (mitochondrial membrane organization), GO:0043524 (negative regulation of neuron apoptotic process), GO:0050954 (sensory perception of mechanical stimulus), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)