Protein: Arginine biosynthesis bifunctional protein ArgJ, mitochondrial [Cleaved into: Arginine biosynthesis bifunctional protein ArgJ alpha chain; Arginine biosynthesis bifunctional protein ArgJ beta chain] [Includes: Glutamate N-acetyltransferase (GAT) (EC 2.3.1.35) (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGS)] (Q5AVF8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
Subcellular location: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03124}.
Sequence: MAPSAQPTAAMATFTRMVKGQMRCYSAPVDAAIPASKRKYIPTSGTYPKGFFVSGTHVGVKASNTKFPDLALITSETPCSAAAVFTTNKFQAAPVQVSKKILNATQGQGIRSVIINSGCANAVTGKGGLEDAMSMATKVDEYTGVAENGTLVMSTGVIGQRLPISKILSKIPEATSSLSSTHDAWLTTARAICTTDTFPKLLSQTFTLPSSPGRTYNIAGMTKGAGMIHPNMATLLGVIATDAPIVPSALQSLLKTSVARSFNAISVDGDTSTNDTVAILANGAAGGAPINSTQNDDYVVMQNILTSFLQSLSQLVVRDGEGATKFVTVRIQNSPDYPSAQLIASTIARSPLVKTALYGRDANWGRILCAIGYTQGVAPGTVVPERTSVSFKPADGSPVLKLLVNGEPEQVDEERASAILQDEDLEIIVDLGGGEKGELGGEEGVYWFCDFSHEYVTINGDYRT
InterPro domains: - IPR002813: Arginine biosynthesis protein ArgJ (family) [32-464]
- IPR042195: ArgJ beta chain, C-terminal domain (homologous_superfamily) [320-464]
- IPR016117: ArgJ-like domain superfamily (homologous_superfamily) [47-461]
Interaction partners: - Acetylglutamate kinase
- Amino-acid acetyltransferase, mitochondrial
- Ornithine carbamoyltransferase, mitochondrial
- acetylornithine transaminase
- Argininosuccinate synthase
- argininosuccinate lyase
- Probable carboxypeptidase AN5749
- Glutamate pyruvate transaminase
- NAD-specific glutamate dehydrogenase
- NADP-specific glutamate dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0009067 (aspartate family amino acid biosynthetic process), GO:0006553 (lysine metabolic process), GO:0009085 (lysine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)