Protein: MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) (Q13368)
Organism: Homo sapiens (Human)
Function: Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:24503895}. Apical cell membrane {ECO:0000269|PubMed:16519681}. Cell junction, adherens junction {ECO:0000269|PubMed:16519681}. Note=Localized in apical villi of Mueller glia cells (By similarity). Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (By similarity). Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (PubMed:16519681). {ECO:0000250|UniProtKB:O88910, ECO:0000269|PubMed:16519681}.
Sequence: MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWVR
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [131-218]
- IPR008144: Guanylate kinase-like domain (domain) [385-570]
- IPR036892: L27 domain superfamily (homologous_superfamily) [67-118]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [181-312]
- IPR001452: SH3 domain (domain) [226-296]
- IPR020590: Guanylate kinase, conserved site (conserved_site) [420-437]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [372-585]
- IPR014775: L27 domain, C-terminal (domain) [12-120]
- IPR050716: Membrane-associated guanylate kinase (family) [7-584]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [384-573]
- IPR001478: PDZ domain (domain) [137-218]
- IPR004172: L27 domain (domain) [6-121]
- IPR035604: MPP3, SH3 domain (domain) [230-291]
Interaction partners: - Protein lin-7 homolog C
- Cell adhesion molecule 1
- Protein lin-7 homolog A
- Cell adhesion molecule 3
- Glutamate receptor ionotropic, NMDA 2A
- Protein lin-7 homolog B
- Glutamate receptor ionotropic, NMDA 2B
- F-box/SPRY domain-containing protein 1
- Tyrosine-protein kinase Lck
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0009888 (tissue development), GO:0048729 (tissue morphogenesis), GO:0060429 (epithelium development), GO:0002009 (morphogenesis of an epithelium), GO:0002011 (morphogenesis of an epithelial sheet)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)