Protein: Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF) (O43915)
Organism: Homo sapiens (Human)
Function: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Subcellular location: Secreted.
Sequence: MYREWVVVNVFMMLYVQLVQGSSNEHGPVKRSSQSTLERSEQQIRAASSLEELLRITHSEDWKLWRCRLRLKSFTSMDSRSASHRSTRFAATFYDIETLKVIDEEWQRTQCSPRETCVEVASELGKSTNTFFKPPCVNVFRCGGCCNEESLICMNTSTSYISKQLFEISVPLTSVPELVPVKVANHTGCKCLPTAPRHPYSIIRRSIQIPEEDRCSHSKKLCPIDMLWDSNKCKCVLQEENPLAGTEDHSHLQEPALCGPHMMFDEDRCECVCKTPCPKDLIQHPKNCSCFECKESLETCCQKHKLFHPDTCSCEDRCPFHTRPCASGKTACAKHCRFPKEKRAAQGPHSRKNP
InterPro domains: - IPR023581: Platelet-derived growth factor, conserved site (conserved_site) [134-146]
- IPR050507: Platelet-derived/Vascular endothelial growth factor (family) [29-315]
- IPR004153: CXCXC repeat (repeat) [261-273]
- IPR000072: PDGF/VEGF domain (domain) [97-196]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [33-200]
Interaction partners: - Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 3
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor B
- Vascular endothelial growth factor C
- Lymphatic vessel endothelial hyaluronic acid receptor 1
- Neuropilin-2
- Fibroblast growth factor receptor 1
- High affinity nerve growth factor receptor
- Angiopoietin-1 receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0042802 (identical protein binding), GO:0030546 (signaling receptor activator activity), GO:0070851 (growth factor receptor binding), GO:0048018 (receptor ligand activity), GO:0005126 (cytokine receptor binding), GO:0005172 (vascular endothelial growth factor receptor binding), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048870 (cell motility), GO:0048584 (positive regulation of response to stimulus), GO:0040017 (positive regulation of locomotion), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0042127 (regulation of cell population proliferation), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0050920 (regulation of chemotaxis), GO:0032101 (regulation of response to external stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0050921 (positive regulation of chemotaxis), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:0008284 (positive regulation of cell population proliferation), GO:0016477 (cell migration), GO:0006929 (substrate-dependent cell migration), GO:0050927 (positive regulation of positive chemotaxis), GO:0050926 (regulation of positive chemotaxis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0030335 (positive regulation of cell migration), GO:0002688 (regulation of leukocyte chemotaxis), GO:0030334 (regulation of cell migration), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0050930 (induction of positive chemotaxis), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0043233 (organelle lumen), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0031091 (platelet alpha granule), GO:0097708 (intracellular vesicle), GO:0031093 (platelet alpha granule lumen)