Protein: Homeobox protein ceh-43 (Q18273)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Binds to the sequence motif 5'-ATAAT-3' in regulatory elements. Required for development of the anterior hypodermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability. Modulates and maintains dopaminergic neuron differentiation. May activate dopamine pathway genes in concert with ETS domain-containing protein ast-1, and homeobox proteins ceh-40 and ceh-20.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Sequence: MDPSKGFEYVAGDYYQTSGVAPPTSNGAGSNVSPYFPYHAYPTSSTNGATGGSMYGTPQQTSAYAMYPPGPGSSPEEAFPEHTTTKIVEGCEAKYNVKGKKMRKPRTIYNSSQLQMLQKKFQKTQYLALPDRAALAHELGLSQTQVKIWFQNRRSKQKKQKGGSSDHASDEEDDDTEESKPESPPMGESVMIQESSEPRTLVSSSIKTEMKEEYPPMTLNEQYASPYLYGSDFSTILPPSQGFPNNALYNTAGAYPSIDYTNGVYQNTLYKYV
InterPro domains: - IPR001356: Homeodomain (domain) [100-164]
- IPR050460: Distal-less homeobox transcription factors (family) [33-221]
- IPR020479: Homeodomain, metazoa (domain) [124-158]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [99-162]
- IPR017970: Homeobox, conserved site (conserved_site) [135-158]
- IPR000047: Helix-turn-helix motif (conserved_site) [131-156]
Interaction partners: - Homeobox protein ceh-32
- Transcription factor ast-1
- Homeobox protein ceh-20
- Homeobox protein ceh-40
- Paired domain-containing protein
- Transcription factor unc-86
- Homeobox protein unc-62
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0003008 (system process), GO:0009887 (animal organ morphogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0007399 (nervous system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0007600 (sensory perception), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0050953 (sensory perception of light stimulus), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0150063 (visual system development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0007601 (visual perception), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)