Protein: Non-homologous end-joining factor 1 (H7C0G7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKELNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWNFHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLKTEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGEPSRGDPHTSNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS
InterPro domains: - IPR038051: XRCC4-like, N-terminal domain superfamily (homologous_superfamily) [1-139]
- IPR053829: XLF-like, coiled-coil region (domain) [127-174]
- IPR015381: XLF-like, N-terminal (domain) [12-124]
- IPR052287: Non-homologous end-joining factor (family) [1-304]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0019899 (enzyme binding), GO:0003677 (DNA binding), GO:0070182 (DNA polymerase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0002440 (production of molecular mediator of immune response), GO:0045321 (leukocyte activation), GO:0002200 (somatic diversification of immune receptors), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0002520 (immune system development), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0002562 (somatic diversification of immune receptors via germline recombination within a single locus), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046649 (lymphocyte activation), GO:0002377 (immunoglobulin production), GO:1901360 (organic cyclic compound metabolic process), GO:0016445 (somatic diversification of immunoglobulins), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0044260 (cellular macromolecule metabolic process), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0006974 (cellular response to DNA damage stimulus), GO:0033151 (V(D)J recombination), GO:0030098 (lymphocyte differentiation), GO:0016447 (somatic recombination of immunoglobulin gene segments), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0042110 (T cell activation), GO:0010212 (response to ionizing radiation), GO:0010467 (gene expression), GO:0042113 (B cell activation), GO:0030217 (T cell differentiation), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0006266 (DNA ligation), GO:1903131 (mononuclear cell differentiation), GO:0030183 (B cell differentiation), GO:0016444 (somatic cell DNA recombination), GO:0006302 (double-strand break repair), GO:0006303 (double-strand break repair via nonhomologous end joining)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0090734 (site of DNA damage), GO:0001650 (fibrillar center), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0140535 (intracellular protein-containing complex), GO:0043233 (organelle lumen), GO:1990391 (DNA repair complex), GO:0035861 (site of double-strand break), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005694 (chromosome), GO:0005634 (nucleus)