wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Polyamine oxidase (A0A8I6A890)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MAARGPRVLVVGGGIAGLGAVQRLCHHRAAPHLRVLEATACAGGRIRSERCFGFLKEHQDTFFEPPLPAKKAEAIRKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDTSPLQDSPLSLQDTWFKKLIGFLVLPSFESSHVLCAFIAGLQSEFMETLSDEEVLLSLTQVLRRVTGNPQLPAAKSVLRSRWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLPADGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREADRLIGLWDSQAEQSRPRL
InterPro domains: - IPR050281: Flavin monoamine oxidase and related enzymes (family) [53-264]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [4-261]
- IPR002937: Amine oxidase (domain) [63-260]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0016647 (oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0009308 (amine metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006576 (biogenic amine metabolic process), GO:0009310 (amine catabolic process), GO:0042402 (cellular biogenic amine catabolic process), GO:0006595 (polyamine metabolic process), GO:0008216 (spermidine metabolic process), GO:0006598 (polyamine catabolic process), GO:0008215 (spermine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: Protocadherin gamma-B5 (PCDH-gamma-B5) (Q9Y5G0)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Sequence: MGSGAGELGRAERLPVLFLFLLSLFCPALCEQIRYRIPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEICGKKPACALEFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGTRFILEVAEDADIGLNSLQKYKLSLNPSFSLIIKEKQDGSKYPELALEKTLDREQQSYHRLVLTALDGGHPPLSGTTELRIQVTDANDNPPVFNRDVYRVSLRENVPPGTTVLQVSATDQDEGINSEITYSFYRTGQIFSLNSKSGEITTQKKLDFEETKEYSMVVEGRDGGGLVAQCTVEINIQDENDNSPEVTFHSLLEMILENAVPGTLIALIKIHDQDSGENGEVNCQLQGEVPFKIISSSKNSYKLVTDGTLDREQTPEYNVTITATDRGKPPLSSSISVILHIRDVNDNAPVFHQASYLVSVPENNPPGASIAQVCASDLDLGLNGQVSYSIMASDLEPLALASYVSMSAQSGVVFAQRAFDYEQLRTFELTLQARDQGSPALSANVSLRVLVGDRNDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQPPLSATATLHLVFADSLQEVLPDITDRPVPSDPQAELQFYLVVALALISVLFLLAVILAVALRLRRSSSPAAWSCFQPGLCVKSGPVVPPNYSQGTLPYSYNLCVAHTGKTEFNFLKCSEQLSSGQDILCGDSSGALFPLCNSSESTSHPELQAPPNTDWRFSQAQRPGTSGSQNGDDTGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [18-814]
- IPR002126: Cadherin-like (domain) [37-671]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [802-923]
- IPR032455: Cadherin, cytoplasmic C-terminal domain (domain) [683-764]
- IPR013164: Cadherin, N-terminal (domain) [32-112]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [32-660]
- IPR020894: Cadherin conserved site (conserved_site) [230-556]
Interaction partners: - Protocadherin gamma-B3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Terminase small subunit (EC 3.6.4.-) (DNA-packaging protein Nu1) (Gene product Nu1) (gpNu1) (P03707)
Organism: Escherichia phage lambda (Bacteriophage lambda)
Function: The small subunit is responsible for the binding to multiple recognition elements within the packaging initiation site cos. The terminase lies at a unique vertex of the procapsid and is composed of two subunits, a small terminase subunit involved in viral DNA recognition (binding to packaging sequence cos), and a large terminase subunit possessing endonucleolytic, ATPase and helicase activities (DNA maturation and packaging) (Probable). The terminase binds, cooperatively with the host factor IHFA/IHFB, to the cos site at the junction of adjacent viral genomes in the concatemeric DNA. The endonuclease and helicase activities of the large subunit cleave the viral DNA generating 5'overhangs of 12 bp in length (Probable). The terminase remains bound to the left end of the genome to be packaged, forming a stable DNA-terminase complex (Probable). In a reaction facilitated by the viral assembly catalyst gpFI, the DNA-terminase complex binds to the portal of the procapsid and the terminase packages the viral DNA into the procapsid until the next cos site on the concatemer reaches the complex (Probable). The downstream cos site is then cut generating the mature right end of the genome, the heterotrimer undocks from the DNA-filled head and remains bound to the left end of concatemer's next genome (Probable).
Subcellular location: Host cytoplasm {ECO:0000305}. Note=The terminase lies at a unique vertex of the procapsid during viral DNA packaging. {ECO:0000305}.
Sequence: MEVNKKQLADIFGASIRTIQNWQEQGMPVLRGGGKGNEVLYDSAAVIKWYAERDAEIENEKLRREVEELRQASEADLQPGTIEYERHRLTRAQADAQELKNARDSAEVVETAFCTFVLSRIAGEIASILDGLPLSVQRRFPELENRHVDFLKRDIIKAMNKAAALDELIPGLLSEYIEQSG
InterPro domains: - IPR010906: Bacteriophage lambda, Nu1, terminase small subunit (family) [1-164]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [1-68]
- IPR009061: Putative DNA-binding domain superfamily (homologous_superfamily) [2-64]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019068 (virion assembly), GO:0019072 (viral genome packaging), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019028 (viral capsid)
Protein: Ribosomal protein L24 (O77067)
Organism: Trypanosoma brucei
Function: Not known
Sequence: MRTIDCEFSHFAVHPGHGRRYVPFAFLSTKPVLTFARPKCFAMYMRKKNPRFIAWTRTYRRIHRKTTTDRVGRRRAARTVRAERAIVGAELSYIQEVRAKAKKVDRTAKGKAVREEMAARKAAKK
InterPro domains: - IPR056366: Large ribosomal subunit protein eL24 (family) [1-119]
- IPR000988: Large ribosomal subunit protein eL24-related, N-terminal (domain) [1-69]
- IPR038630: Ribosomal protein L24e/L24 superfamily (homologous_superfamily) [1-64]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043168 (anion binding), GO:0042301 (phosphate ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: 11-oxo-beta-amyrin 30-oxidase (EC 1.14.14.115) (Cytochrome P450 72A63) (H1A981)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Involved in the biosynthesis of triterpenoid saponins. Catalyzes three sequential oxidation steps at C-30 of 11-oxo-beta-amyrin. Also able to catalyze sequential C-30 hydroxylation of beta-amyrin to produce 30-hydroxy-beta-amyrin and 11-deoxoglycyrrhetinic acid.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MEVFMFPTGTTVIISVLSVLLAVIPWYLLNKLWLKPKRFEKLLKAQGFQGEPYNLSVLKDKSKQNYMLKLQQEDKSKSIGLSKEAAPSIFTPVHQTVRKYGNNSFLWEGTTPRVIITDPDQIKDVFNKIDDFPKPKLRSIAKYLSVGILDHEGKKWAKHRKIANPAFHLEKLKVMLPAFSHSCNEMISKWKELLSSDGTCEIDVWPSLQNFTCDVISRTAFGSSYAEGTKLFQLLKKQGFLLMTGRHTNNPLWGLLATTTKTKMKEIDREIHDSLEGIIEKREKALKNGETTNDDLLGILLQSNHAEKQGQGNSKNIGMTTQDVIDECKLFYLAGQETTSSLLVWTMVLLGRYPEWQARAREEVLQVFGNQNPNNEGLSQLKIVTMILYEVLRLFPPLIYFNRALRKDLKLGNLLLPEGTQISLPILLIHQDHDLWGDDAKEFKPERFAEGIAKATKGQVSYFPFGWGPRICLGQNFALLEAKIAVSLLLQNFSFELSPNYVHVPTTVLTLQPKNGASIILHKL
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [82-523]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [465-474]
- IPR001128: Cytochrome P450 (family) [93-500]
- IPR002401: Cytochrome P450, E-class, group I (family) [97-495]
- IPR050665: Plant Cytochrome P450 Monooxygenases (family) [24-517]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:1901657 (glycosyl compound metabolic process), GO:0016137 (glycoside metabolic process), GO:1901659 (glycosyl compound biosynthetic process), GO:0016138 (glycoside biosynthetic process), GO:0016134 (saponin metabolic process), GO:0016135 (saponin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: SH3 domain-containing protein (Q59U90)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MVVDQLKNNIVSISSNIGTHIKDGYKYTESEFKNISYNIKDTVTFHTRDYDKDDELVEIYYHDIKQSVSGLKYITSQNHHLSKSFLPHVLSSNIKIIKGFINLIGQDSLRFDKINEYYQEFDSWQATQEIPHVHPKEMQFLNESINEELNNYLITVENLKFDLENNWEAYDESLKYRIDEMKKYLKKTLKLIKKRNMKRTEQDHLHRKIEKLNQKAIPLDEKDNDKLEKLETTYQTVDAAFNSLNKKCIQLLPNIVSFLDEFVENITKMILCQQLETFKKLTDTFQYFTEFYGLIKENSPKSYTEIIDDWESNSTATRLQIESLLTIVHEKHPDLLDKEINDEDSSSNYYRFWRNMSNKFVEKKHVVNTKDKVNGIFNDTLEIDPLVAYKQYQDPSMNPSETYHPRKLVDEEDIKVPAVPKKDGPELPPRSNTAIVRHSVLVSPMSSAGASRLYSISTDSMDSISLSDFEDESATIMSEASSISSMSSVSYSNHDSSEAKLRRIYNGSKNEIKESPITTKPIQYEPFTFEKPMSLTYKLNLIQSFFEKLNINTDNKVLKTAKYDFSGYEPGDLSFKQGDNIEILLDFQNIDTLYHSDELNWLIGVSRIDDESYRIGFVPNNYVE
InterPro domains: - IPR001452: SH3 domain (domain) [554-624]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [20-301]
- IPR046982: Bridging integrator 3/RVS161-like (family) [22-624]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [559-624]
Interaction partners: - RVS161-like protein RVS162
- Abp1p
- Regulator of cytoskeleton and endocytosis RVS161
- Regulator of cytoskeleton and endocytosis RVS167
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0016043 (cellular component organization), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: glutathione transferase (EC 2.5.1.18) (C8BLR5)
Organism: Meleagris gallopavo (Wild turkey)
Function: Not known
Sequence: MSEKPRLTYINGRGRMESIRWLLAAAGVEFEEIFLQTREQLLKLGQDGSLMFHQLPLVEIDGMKLVQCRAILSYIAGKYNLYGKDLKERALIDMYVEGISDLMQLILMFPFSPPEAKEKNIATISEKATERYFPVFEKVLKQHGQDFLVGNRFSWADVQLMEAILAVEEKVPSVLSGFPQLQAFKTKMSNMPTIKKFLQPGSPRKPPPDENYVATVMKIFKLD
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [5-80]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [80-220]
- IPR003080: Glutathione S-transferase, alpha class (family) [15-209]
- IPR050213: Glutathione S-transferase superfamily (family) [5-202]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [101-199]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [85-209]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [3-83]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004364 (glutathione transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0009404 (toxin metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009636 (response to toxic substance), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:0043385 (mycotoxin metabolic process), GO:0046222 (aflatoxin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Protein ABHD15 (Alpha/beta hydrolase domain-containing protein 15) (Abhydrolase domain-containing protein 15) (Q6UXT9)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000305}.
Sequence: MPPWGAALALILAVLALLGLLGPRLRGPWGRAVGERTLPGAQDRDDGEEADGGGPADQFSDGREPLPGGCSLVCKPSALAQCLLRALRRSEALEAGPRSWFSGPHLQTLCHFVLPVAPGPELAREYLQLADDGLVALDWVVGPCVRGRRITSAGGLPAVLLVIPNAWGRLTRNVLGLCLLALERGYYPVIFHRRGHHGCPLVSPRLQPFGDPSDLKEAVTYIRFRHPAAPLFAVSEGSGSALLLSYLGECGSSSYVTGAACISPVLRCREWFEAGLPWPYERGFLLHQKIALSRYATALEDTVDTSRLFRSRSLREFEEALFCHTKSFPISWDTYWDRNDPLRDVDEAAVPVLCICSADDPVCGPPDHTLTTELFHSNPYFFLLLSRHGGHCGFLRQEPLPAWSHEVILESFRALTEFFRTEERIKGLSRHRASFLGGRRRGGALQRREVSSSSNLEEIFNWKRSYTR
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [124-422]
- IPR050960: AB hydrolase superfamily, subfamily 4 (family) [71-419]
Interaction partners: - cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) (P04080)
Organism: Homo sapiens (Human)
Function: This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11139332}. Nucleus {ECO:0000269|PubMed:11139332}.
Sequence: MMCGAPSATQPATAETQHIADQVRSQLEEKENKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKPLTLSNYQTNKAKHDELTYF
InterPro domains: - IPR046350: Cystatin superfamily (homologous_superfamily) [1-98]
- IPR000010: Cystatin domain (domain) [1-98]
- IPR018073: Proteinase inhibitor I25, cystatin, conserved site (conserved_site) [45-58]
- IPR001713: Proteinase inhibitor I25A, stefin (family) [1-98]
Interaction partners: - Procathepsin L
- Cathepsin B
- Cathepsin S
- Ribosomal RNA processing protein 1 homolog B
- Cystatin-C
- E3 ubiquitin-protein ligase NHLRC1
- Ribosomal RNA processing protein 1 homolog A
- Prickle-like protein 1
- Trafficking protein particle complex subunit 10
- Apolipoprotein D
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0019899 (enzyme binding), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0002020 (protease binding), GO:0004866 (endopeptidase inhibitor activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1990000 (amyloid fibril formation), GO:0097435 (supramolecular fiber organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: dihydrofolate reductase (EC 1.5.1.3) (Q76S40)
Organism: Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Not known
Sequence: MDPTLYCVVAVDTKLGIGKNRCLPWPALRGDMRRFRQLTTDCAPGKQNMVVMGRRTWLSIPAGCRPLAGRINVVLSRTLETPPPGAHFLASSLDAALGLARSPELAQQIDKVWVIGGGDLYREALTGPWPVRLFLTRVLHDFACDVFLSHDSLAAYARVNPKPGEQERVFQERGIFYMFETYIKVTQSSDTALPDLERPRPATPPFSETS
InterPro domains: - IPR017925: Dihydrofolate reductase conserved site (conserved_site) [16-39]
- IPR001796: Dihydrofolate reductase domain (domain) [4-184]
- IPR012259: Dihydrofolate reductase (family) [2-184]
- IPR024072: Dihydrofolate reductase-like domain superfamily (homologous_superfamily) [3-185]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)