Protein: DNA repair protein rad60 (Q9USX3)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for repair of DNA double strand breaks which occur during replication, or induced by UV or gamma radiation, via recombination between sister chromatids. This has a subsequent role in the maintenance of chromosome structure. May work in conjunction with the Smc5-Smc6 complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:11971984}.
Sequence: MDNLDEDDLAFFSKPIKKPPLNYAKQLIASSSDSEEESELDTNKQALEHINAQKNITHNENKSAEPLSRQSTILDADEGNQDVSDTTPNACLNEGRHSPKSAISCVTQPVSPVYNTRAAANLRNNSINSEAALSTTSSLLDDDFARRLEEIDRQVQEFEKSSSDMDVQIHTHKREIEEDDDNTSADVPLLKHSKSDHSTLYHSKSEFSTNEPVISVVLQLAVIGQRIPNSNISLPRDWEAPLFFKVKSNQQFRRVRIAYSERKKVDNVVLVFQNQRLWDYGTPKGAGMLKVDTRLVVHAYCHSDFISLKRIKELEVEKLSSVTEDSTAQTCKLITLLLRSSKSEDLRLSIPVDFTVKDLIKRYCTEVKISFHERIRLEFEGEWLDPNDQVQSTELEDEDQVSVVLD
InterPro domains: - IPR022617: Rad60/SUMO-like domain (domain) [334-405]
- IPR000626: Ubiquitin-like domain (domain) [334-406]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [239-405]
Interaction partners: - SUMO-conjugating enzyme ubc9
- Structural maintenance of chromosomes protein 6
- Ubiquitin-like protein pmt3/smt3
- E3 SUMO-protein ligase pli1
- E3 SUMO-protein ligase nse2
- Ubiquitin-activating enzyme E1-like
- E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8
- Ubiquitin-like-specific protease 1
- Asteroid homolog 1
- Serine/threonine-protein kinase cds1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0044786 (cell cycle DNA replication), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0033260 (nuclear DNA replication), GO:1902969 (mitotic DNA replication), GO:0006259 (DNA metabolic process), GO:0045005 (DNA-templated DNA replication maintenance of fidelity), GO:0006260 (DNA replication), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0006261 (DNA-templated DNA replication), GO:0000725 (recombinational repair), GO:0031297 (replication fork processing), GO:0006301 (postreplication repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)