Protein: Centriole, cilia and spindle-associated protein (Q6P3G4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in embryonic development, including proper left-right asymmetry formation. Also required for proper cilia beating. Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, axon {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6IQ19}. Note=Localizes at specific foci at the apical surface of neuroepithelial cells where cilia form along the brain ventricle lumen. {ECO:0000269|PubMed:22493317}.
Sequence: MVTKRIRSEYMKKFKDPKWDTYAKCYEDLLKYRLSRRLLEQAHKPWFWGEWGSETASSGKSTPLSRNKVEPLKTLDEKPERSACVTPEPAAEAETQAAEVQDREHADTNLVPCDAEVAHPEGEEVRGKERSPAVNPDSDTQIQNMSKSKRRSSHKYTRSKVKPQAPKDPDKENRHPFALYGAGEKQTDMASKKTHNVGPAASTAEIHESALRAKTRREVEKQIKRFDKQRARSADLEKSRNKIIPDFNPWMTEYMRCFSARSR
InterPro domains: - IPR029774: Centriole, cilia and spindle-associated protein (family) [1-263]
Interaction partners: - Centrosomal protein 120.
- Centrosomal protein of 135 kDa
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0032989 (cellular component morphogenesis), GO:0007018 (microtubule-based movement), GO:0000902 (cell morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0060041 (retina development in camera-type eye), GO:0031109 (microtubule polymerization or depolymerization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0032990 (cell part morphogenesis), GO:0007423 (sensory organ development), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0007052 (mitotic spindle organization), GO:0006996 (organelle organization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0097435 (supramolecular fiber organization), GO:0048666 (neuron development), GO:0007010 (cytoskeleton organization), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048925 (lateral line system development), GO:0051493 (regulation of cytoskeleton organization), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0021954 (central nervous system neuron development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0031400 (negative regulation of protein modification process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0021955 (central nervous system neuron axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0005879 (axonemal microtubule), GO:0005881 (cytoplasmic microtubule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0097014 (ciliary plasm), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)