Protein: Skywalker, isoform D (Skywalker, isoform E) (Skywalker, isoform G) (Q0E8N9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000256|ARBA:ARBA00004156}. Endomembrane system {ECO:0000256|ARBA:ARBA00004184}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004184}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Sequence: MPYHRGGDASSQADKLSGIVEESDLYEGFAPHVETSEIKTLDFYNLPKQTGKEPALRSYTEIQQLLQQGKKRDVKNILRENSWPINSPIRAQLWPMLCGQHQTKQQMLDGFYWEMVHQVFGTTELSEKPIMLPAFVDATHCLPYHLTSTGRAVADRIVNVLGYDCPDITYSPVLYPITSILLHFMSEEEAYICLAGLVGSKEKVFINQTKLQHEVTWKTVMQIAKKHTKSATSYFQRICPGLKLERIFMDWCWWILAGLPFQHLVRIMDCYFHEGIKVLYRVALVILNLFHKECQSNNEWSPDNIKNDIGNALIKFCKKIPVSPAKLLHAAFSIRGLSTQYISRIFIKTEMLLKSRSVLTSGSKQLIKSRSSDNLPTSQSQVNIQMMSHTLTIRELFTLWSWLPVRITMYQPVLLYTTEEHGCSLTTFYVRVEQHEPTLLMIKTCNNEVFGAYCSSRWFERNVKDDKGQRQAYFGTGETFLFSLYPERAKYPWVGIEGDKDLGHSSELFMAADSKMITIGGGEGQAIWMDENIRFGKTDSCKTFNNPPLCPSGDFEIRVLEVYGFVGI
InterPro domains: - IPR035969: Rab-GAP-TBC domain superfamily (homologous_superfamily) [83-202]
- IPR000195: Rab-GAP-TBC domain (domain) [81-298]
- IPR006571: TLDc domain (domain) [388-566]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0007267 (cell-cell signaling), GO:0051641 (cellular localization), GO:0065008 (regulation of biological quality), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0099536 (synaptic signaling), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0001505 (regulation of neurotransmitter levels), GO:0099177 (regulation of trans-synaptic signaling), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0051588 (regulation of neurotransmitter transport), GO:0036465 (synaptic vesicle recycling), GO:0099504 (synaptic vesicle cycle), GO:0046928 (regulation of neurotransmitter secretion), GO:0016197 (endosomal transport), GO:0050804 (modulation of chemical synaptic transmission), GO:0099537 (trans-synaptic signaling), GO:0036466 (synaptic vesicle recycling via endosome), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:1903421 (regulation of synaptic vesicle recycling), GO:0098916 (anterograde trans-synaptic signaling), GO:0099003 (vesicle-mediated transport in synapse), GO:0099532 (synaptic vesicle endosomal processing), GO:0007268 (chemical synaptic transmission), GO:0007274 (neuromuscular synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098793 (presynapse), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0043195 (terminal bouton), GO:0043005 (neuron projection), GO:0031594 (neuromuscular junction), GO:0030424 (axon)