Protein: G protein-activated inward rectifier potassium channel 3 (F1R7M8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence: MGAARVKRRFSAVVDTPLDEEEVMRLAQSDDGTSSHSGTLPSPNCNGKVLSILHSNGGRSGERDEDEDDDDADKDDDDEEEGGGRRGGGGRGSALSGESGVEGRWERNKRASLPSLSPTPLRDRRRQSRRPRRRFVGKDGRCNVTFVNMSERGQRYLTDLFTTCVDIRWRWMLVVFTLSFLLTWLLFGFTFWLIAAAHGDLNPLASSSSSPSSLSSSLAPLDATEGSSRVEMVAETEEPCFQQVNSFMAAFLFSLETQTSIGYGFRSVTEACPLAVLAVVLQCIVGCIIDAFIIGAVMAKIAKPKKRNETLVFSDVAVVAVRDGKLCMMWRVGNLRKSHLVEAHVRAQLLKPRVTPEGEFLPLDNSDLNVGFDTGTDRIFLVSPVTIVHEINEESPFFEMDKGALEGDKDLEVVVILEGMVEATAMTTQCRSSFLASEILWGHRFEPVLFERKNCYQVDYSYFNRTYEVTDTPTCSAKELAEKKYIARSRSSFCYENEVALQLSSSVPPCADQFSPSPCSSPPQSPTPPPRQDSCSEHPHKH
InterPro domains: - IPR016449: Potassium channel, inwardly rectifying, Kir (family) [115-484]
- IPR041647: Inward rectifier potassium channel, C-terminal (domain) [311-484]
- IPR013518: Potassium channel, inwardly rectifying, Kir, cytoplasmic (homologous_superfamily) [134-479]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [286-485]
- IPR040445: Potassium channel, inwardly rectifying, transmembrane domain (domain) [136-304]
Interaction partners: - Ankyrin repeat domain 33Ab
- Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
- WD repeat domain 17
- Coiled-coil domain-containing 126
- Potassium voltage-gated channel subfamily B member 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity), GO:0005242 (inward rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0031018 (endocrine pancreas development), GO:0035270 (endocrine system development), GO:0003309 (type B pancreatic cell differentiation), GO:0002064 (epithelial cell development), GO:0060429 (epithelium development), GO:0031016 (pancreas development), GO:0030855 (epithelial cell differentiation), GO:0002066 (columnar/cuboidal epithelial cell development), GO:0003323 (type B pancreatic cell development), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0002068 (glandular epithelial cell development), GO:0002067 (glandular epithelial cell differentiation), GO:0035883 (enteroendocrine cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)