Protein: TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) (Q99576)
Organism: Homo sapiens (Human)
Function: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q9Z2S7}. Nucleus {ECO:0000250|UniProtKB:Q9Z2S7}. Note=Localization depends on differentiation status of myoblasts (By similarity). In undifferentiated myoblasts; localizes to the cytoplasm, but in differentiating myoblast; localizes to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Z2S7}.
Sequence: MNTEMYQTPMEVAVYQLHNFSISFFSSLLGGDVVSVKLDNSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELVEKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
InterPro domains: - IPR047862: TSC22/Bun, conserved site (conserved_site) [58-74]
- IPR000580: TSC22/Bun (family) [58-113]
Interaction partners: - RAF proto-oncogene serine/threonine-protein kinase
- Serine/threonine-protein kinase Sgk1
- Nuclear receptor-binding protein
- E3 ubiquitin-protein ligase NEDD4-like
- TSC22 domain family protein 1
- TSC22 domain family protein 2
- Glucocorticoid receptor
- Peptidyl-prolyl cis-trans isomerase FKBP5
- Dual specificity protein phosphatase 1
- Tubulin polyglutamylase TTLL5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0050777 (negative regulation of immune response), GO:0010942 (positive regulation of cell death), GO:0050776 (regulation of immune response), GO:0010941 (regulation of cell death), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0036293 (response to decreased oxygen levels), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)