Protein: Aromatase (EC 1.14.14.14) (CYPXIX) (Cytochrome P-450AROM) (Cytochrome P450 19A1) (Estrogen synthase) (Q92112)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Subcellular location: Membrane; Peripheral membrane protein.
Sequence: MVLETLNPLHYNITSLVPDTMPVATVPILILMCFLFLIWNHEETSSIPGPGYCMGIGPLISHGRFLWMGVGNACNYYNKTYGDFVRVWISGEETFIISKSSSVSHVMKHWHYVSRFGSKLGLQCIGMYENGIIFNNNPAHWKEIRPFFTKALSGPGLVRMIAICVESTTEHLDRLQEVTTELGNINALNLMRRIMLDTSNKLFLGVPLDENAIVLKIQNYFDAWQALLLKPDIFFKISWLCKKYKDAVKDLKGAMEILIEQKRQKLSTVEKLDEHMDFASQLIFAQNRGDLTAENVNQCVLEMMIAAPDTLSVTLFFMLILIAEHPTVEEEMMREIETVVGDRDIQSDDMPNLKIVENFIYESMRYQPVVDLIMRKALQDDVIDGYPVKKGTNIILNIGRMHKLEFFPKPNEFSLENFEKNVPSRYFQPFGFGPRSCVGKFIAMVMMKAILVTLLRRCRVQTMKGRGLNNIQKNNDLSMHPIERQPLLEMVFTPRRNANENQGDGMDQH
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [45-503]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [430-439]
- IPR001128: Cytochrome P450 (family) [49-484]
- IPR002401: Cytochrome P450, E-class, group I (family) [78-460]
- IPR050196: Cytochrome P450 Monooxygenases (family) [77-468]
Interaction partners: - Estradiol 17-beta-dehydrogenase
- Hydroxysteroid 17-beta dehydrogenase 12
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cytochrome P450 1A
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- unspecific monooxygenase
- Hydroxysteroid 17-beta dehydrogenase 2
- 3-oxo-5-alpha-steroid 4-dehydrogenase
- Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
- 3-oxo-5-alpha-steroid 4-dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:1905953 (negative regulation of lipid localization), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:1905954 (positive regulation of lipid localization), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0051051 (negative regulation of transport), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0035176 (social behavior), GO:0042445 (hormone metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:1901576 (organic substance biosynthetic process), GO:0046887 (positive regulation of hormone secretion), GO:0032370 (positive regulation of lipid transport), GO:1905952 (regulation of lipid localization), GO:0048731 (system development), GO:0008210 (estrogen metabolic process), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0042446 (hormone biosynthetic process), GO:0051048 (negative regulation of secretion), GO:0046883 (regulation of hormone secretion), GO:1901360 (organic cyclic compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0006629 (lipid metabolic process), GO:0009888 (tissue development), GO:2000833 (positive regulation of steroid hormone secretion), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0032369 (negative regulation of lipid transport), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:1903531 (negative regulation of secretion by cell), GO:0008284 (positive regulation of cell population proliferation), GO:1903532 (positive regulation of secretion by cell), GO:0050890 (cognition), GO:1901362 (organic cyclic compound biosynthetic process), GO:2000831 (regulation of steroid hormone secretion), GO:0032355 (response to estradiol), GO:0071310 (cellular response to organic substance), GO:0008202 (steroid metabolic process), GO:0006703 (estrogen biosynthetic process), GO:0044060 (regulation of endocrine process), GO:0032368 (regulation of lipid transport), GO:0007613 (memory), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0033993 (response to lipid), GO:2000843 (regulation of testosterone secretion), GO:0007417 (central nervous system development), GO:0051046 (regulation of secretion), GO:0014070 (response to organic cyclic compound), GO:2000027 (regulation of animal organ morphogenesis), GO:1901701 (cellular response to oxygen-containing compound), GO:0008610 (lipid biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0071392 (cellular response to estradiol stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0120178 (steroid hormone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0043195 (terminal bouton), GO:0043005 (neuron projection), GO:0030425 (dendrite), GO:0030424 (axon)