Protein: C-reactive protein [Cleaved into: C-reactive protein(1-205)] (P02741)
Organism: Homo sapiens (Human)
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Subcellular location: Secreted.
Sequence: MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
InterPro domains: - IPR001759: Pentraxin-related (family) [19-224]
- IPR030476: Pentaxin, conserved site (conserved_site) [113-120]
- IPR051005: Pentraxin domain-containing protein (family) [1-223]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [20-224]
Interaction partners: - Complement factor H
- Low affinity immunoglobulin gamma Fc region receptor II-a
- Complement factor H-related protein 4
- Complement C3
- Interleukin-6
- Oxidized low-density lipoprotein receptor 1
- Tumor necrosis factor
- Albumin
- Alanine aminotransferase 1
- Leptin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0001848 (complement binding), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0051082 (unfolded protein binding), GO:0001846 (opsonin binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048525 (negative regulation of viral process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0006457 (protein folding), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0044092 (negative regulation of molecular function), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:1903706 (regulation of hemopoiesis), GO:0031324 (negative regulation of cellular metabolic process), GO:1903901 (negative regulation of viral life cycle), GO:0045087 (innate immune response), GO:1903707 (negative regulation of hemopoiesis), GO:0098542 (defense response to other organism), GO:0031348 (negative regulation of defense response), GO:2000026 (regulation of multicellular organismal development), GO:1903900 (regulation of viral life cycle), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0052372 (modulation by symbiont of entry into host), GO:1903035 (negative regulation of response to wounding), GO:0032102 (negative regulation of response to external stimulus), GO:0046596 (regulation of viral entry into host cell), GO:0031347 (regulation of defense response), GO:0043086 (negative regulation of catalytic activity), GO:0050728 (negative regulation of inflammatory response), GO:0061045 (negative regulation of wound healing), GO:1902106 (negative regulation of leukocyte differentiation), GO:1903034 (regulation of response to wounding), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0060284 (regulation of cell development), GO:0051248 (negative regulation of protein metabolic process), GO:1903018 (regulation of glycoprotein metabolic process), GO:0022607 (cellular component assembly), GO:0045637 (regulation of myeloid cell differentiation), GO:0006954 (inflammatory response), GO:0050727 (regulation of inflammatory response), GO:0045638 (negative regulation of myeloid cell differentiation), GO:1902105 (regulation of leukocyte differentiation), GO:0043933 (protein-containing complex organization), GO:0046597 (negative regulation of viral entry into host cell), GO:0010721 (negative regulation of cell development), GO:0002762 (negative regulation of myeloid leukocyte differentiation), GO:0051346 (negative regulation of hydrolase activity), GO:0065003 (protein-containing complex assembly), GO:0002673 (regulation of acute inflammatory response), GO:0002526 (acute inflammatory response), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:0061041 (regulation of wound healing), GO:0006953 (acute-phase response), GO:0045655 (regulation of monocyte differentiation), GO:0051131 (chaperone-mediated protein complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0072562 (blood microparticle), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030312 (external encapsulating structure), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)