Protein: EGF-like-domain, multiple 6 (Q6DHG1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence: MSGLGVCRYGSRLECCYGWKKNTKGQCEAQCDLGCKHGECVGPNKCKCFPGYTGKTCSQDLNECGLKPRPCEHRCMNTFGSYMCYCLNGYMLMPDGSCANSRTCSLAHCQYGCEEVQSEVRCLCPSPGLQLGSDGKTCEDIDECATGKNQCPFNRQCTNTFGSYYCKCQPGYDLKYINGKYDCVDVNECTSNTHKCSHHAECINTLGSYKCKCKQGFRGSGFDCSVKPFYHRSWDSSKGNTDVLVNAIPDFPSKTRILGKFENSIPEPVLTESPRQHLQPFDYDGEVYIGAPQETPVFPEEEEVEEEEEEDTENQLEDEELTSRGDVFSQDDFVSFYQSELELKEIQAAPLKERFLTDCDFDRGACEWVQDNADDLDWTIKYHPDGREYYLALEGPVGNRREQARMKLLLEDHMRQSSFCLRFDFRIEGPQTGVLRVKLDNSAISIWERKQSQKQSWQSEQISISWTDSNPEAVVFEAERGRSGTGEIALDHVLLISGECSEDKTLDF
InterPro domains: - IPR000742: EGF-like domain (domain) [30-225]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [357-500]
- IPR000998: MAM domain (domain) [354-502]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [185-211]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [75-213]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [60-224]
- IPR052235: Nephronectin domain-containing protein (family) [5-500]
- IPR001881: EGF-like calcium-binding domain (domain) [60-225]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [104-225]
Interaction partners: - Rhomboid-related protein 1
- WD repeat-containing protein 90
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0023051 (regulation of signaling), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:0009790 (embryo development), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0048513 (animal organ development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045766 (positive regulation of angiogenesis), GO:0048568 (embryonic organ development), GO:0045765 (regulation of angiogenesis), GO:0008593 (regulation of Notch signaling pathway), GO:1901342 (regulation of vasculature development), GO:0030903 (notochord development), GO:1903670 (regulation of sprouting angiogenesis), GO:1903672 (positive regulation of sprouting angiogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0005604 (basement membrane)