Protein: Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-) (Q7SXM0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of non-histone proteins. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9BY41}. Chromosome {ECO:0000250|UniProtKB:Q9BY41}. Cytoplasm {ECO:0000250|UniProtKB:Q9BY41}. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. {ECO:0000250|UniProtKB:Q9BY41}.
Sequence: MSEKSDSNDDKSRTRSVVYVYSPEYIQTCDSLSKVPNRASMVHSLIEAYGLLKYMRVVKPHVASIEEMAVFHTDSYLQHLHKISQDGDNDDPQSADFGLGYDCPVVEGIFDYAAAVGGATLTAAQNLLDGKCDVAINWAGGWHHAKKDEASGSCYVNDAVLGILKLREKYDRVLYVDVDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVTDTGLGKGRWYAVNVPFEDGVRDDRYCQTFTSVMQEVKALFNPEAVVMQLGADTMAGDPMCSFNMTPVGVAKCLTYILGWELPTLLLGGGGYNLANTARCWTYLTGTVLGQTLSSEIPDHEFFTEYGPDYSLEISPSCRPDRNESQHLERVISTIKGNLKNVV
InterPro domains: - IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [3-378]
- IPR000286: Histone deacetylase HDAC (family) [140-268]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [16-376]
- IPR003084: Class I/II Histone deacetylase HDAC (family) [1-378]
- IPR023801: Histone deacetylase domain (domain) [35-321]
Interaction partners: - Structural maintenance of chromosomes protein.
- Si:ch211-262i1.5
- Si:ch211-9d9.1.
- AT-rich interactive domain-containing protein 4B
- AT-rich interactive domain-containing protein 4A
- Mortality factor 4-like protein 1
- SDS3 homolog, SIN3A corepressor complex component)
- Structural maintenance of chromosomes protein
- F-box-like/WD repeat-containing protein TBL1XR1a
- F-box-like/WD repeat-containing protein TBL1X
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0003714 (transcription corepressor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0035239 (tube morphogenesis), GO:0022008 (neurogenesis), GO:0048882 (lateral line development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0002064 (epithelial cell development), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0007423 (sensory organ development), GO:0006325 (chromatin organization), GO:0060429 (epithelium development), GO:0002040 (sprouting angiogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0030855 (epithelial cell differentiation), GO:0045446 (endothelial cell differentiation), GO:0048925 (lateral line system development), GO:0035315 (hair cell differentiation), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0048884 (neuromast development), GO:0048916 (posterior lateral line development), GO:0048881 (mechanosensory lateral line system development), GO:0048886 (neuromast hair cell differentiation), GO:0048915 (posterior lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0000118 (histone deacetylase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)