Protein: Engulfment and cell motility 1 (ced-12 homolog, C. elegans) (A0A8M3ASM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1
Subcellular location: Cytoplasm. Membrane
Sequence: MPPPADIVKVAIEWPGAFPKLMEIDQKKPLSAIIKEVCEGWNLPNPETYALQNADATNFYITEKNRNNIKNGSILRLTTSAAQMAQQLHERIQSSSMDMKLDALKDLANSSRDITFAQEFINLDGISLLTQMVESGTERYQKLQKIMKPCFGDLLSFTLTAFVELMDHGIVSWDTFSVAFIKKIASYVCKSAMDTAVLQRSLAILESMVLNSQDLYQKVAQEITIGQLIPHLQGTDQDIQTYTIAVINALFLKAPEEKRQFDGDNVNILDCPLTEMAHILAQKQLRSIILSNVIRSNKPINDEMAHQLYVLQVLTFNLLEDRMMTKMDPQDQAQRDIIFELRRIAFDVECESNNSGSIEKRKSMYTRDYKKLGFINHVNPAVDFTQIPPGMLALDNMLYFARHHQDAYIRIVLENSSREDKHECPFGRSSIELTKMLCEILKVGELPSENCHDFHPMFFTHDRSFEEFFCICIQLLNKTWKEMRATSEDFNKVMQVVKEQITRALTIKPNSLDQFKSRLQNLSYTEILKLRQSERMNQEDFQSRPILELREKIQPEIMELIKQQRLNRLCEGTCFRKISSRRRQDKFWYCRLSPNHKVLHYGDLEESPQGEVPHDSLQDKLPVADIKAVVTGKDCPHMKEKGALKQNKEVLELAFSVLYESDEYLNFIAPDKHEYCVWTDGLNALLGKEMSSEFTRSDMDTLLNMEMKLRLLDLENIQIPEVPPPIPKEPSNYDFVYDCN
InterPro domains: - IPR011993: PH-like domain superfamily (homologous_superfamily) [572-688]
- IPR016024: Armadillo-type fold (homologous_superfamily) [81-259]
- IPR011989: Armadillo-like helical (homologous_superfamily) [15-270]
- IPR001849: Pleckstrin homology domain (domain) [561-687]
- IPR024574: ELMO, armadillo-like helical domain (domain) [115-294]
- IPR050868: Engulfment and cell motility domain-containing protein (family) [62-638]
- IPR006816: ELMO domain (domain) [317-505]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0044085 (cellular component biogenesis), GO:0036303 (lymph vessel morphogenesis), GO:0048731 (system development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0001945 (lymph vessel development), GO:0001946 (lymphangiogenesis), GO:0030030 (cell projection organization), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0060271 (cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)