wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Ceramide synthase 5 (A0A0G2JXZ1)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus
Sequence: MATAAAEALGLLWGWLWSGRFWLPQNVSWADLEGPGDGYGYPRARHVLSVFPLAAGLFSVRMLFERFIAKPCALRIGIEDSAVYQVESNVTLEKVFTSISKYPDEKRLKGLSKQLDWDVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYFCIFCYGVRFLWSVSLNSLSSHWLYYYYLTQLAFYWSLVFSQFIDVKRKDFLMMFMHHLIAVTLISFSYINNMVRVGAIILCLHDSADSLLEAAKLANYARQERLCNTLFVIFGAAFMVTRLGIFPLWILNTTLFESWEIIGPFPSWWLFNGLLLILQMLHVIWSYLIARTAFKALVRGKVSKDDRSDVESSSEEDETTHTNNLSGSSSSNGANCMNGRMGGSHLAEEQGTCKAAGNLHFGASPRIHSCD
InterPro domains: - IPR016439: Sphingosine N-acyltransferase Lag1/Lac1-like (family) [9-376]
- IPR001356: Homeodomain (domain) [90-136]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [82-134]
- IPR006634: TRAM/LAG1/CLN8 homology domain (domain) [139-340]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:2000026 (regulation of multicellular organismal development), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0008285 (negative regulation of cell population proliferation), GO:0050768 (negative regulation of neurogenesis), GO:0006996 (organelle organization), GO:0010721 (negative regulation of cell development), GO:0010256 (endomembrane system organization), GO:0060284 (regulation of cell development), GO:0061024 (membrane organization), GO:0006998 (nuclear envelope organization), GO:0006997 (nucleus organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: E3 ubiquitin-protein ligase TRIM8 (D3ZQE3)
Organism: Rattus norvegicus (Rat)
Function: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction
Sequence: MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPTALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQERLEEREQDIEDQLYKLESDKRLVEEKVSQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTGSSLSPPKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVNSSGAEKRKHSTAFPEASFLETSSGPVGSQYGAAGPASSEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSATQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLSGLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [15-56]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [30-39]
- IPR051051: E3 ubiquitin-protein ligase TRIM/RNF (family) [10-347]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [15-53]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1-53]
- IPR058030: TRIM8/14/16/25/29/45/65, coiled-coil region (domain) [205-323]
Interaction partners: - Suppressor of cytokine signaling 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0009991 (response to extracellular stimulus), GO:1901700 (response to oxygen-containing compound), GO:0007584 (response to nutrient), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0014070 (response to organic cyclic compound), GO:0043627 (response to estrogen), GO:0033273 (response to vitamin), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0033280 (response to vitamin D)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: LOC687713 protein (B5DFC7)
Organism: Rattus norvegicus (Rat)
Sequence: MRTEVEAAGQPLEPEDFVQLPVPTIQQLYHWDCGLACSRMVLRYLGQLDDREFENALQELQLTRSIWTIDLAYLMRHFGVRHRFCTQTLGVDKGYKNQSFYRKHFDTEETRVNQLFAQAKACKVQVEKCTVSVQDIQAHLAQGHVAIVLVNSGVLHCELCSSPVKYCCFTPRGHRCFCRAPDYQGHFIVLRGYNRATGCIFYNNPAYADRMCSTSISNFEEARTSYGTDEDILFVYLDS
InterPro domains: - IPR018616: Protein GUCD1 (family) [6-238]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0031100 (animal organ regeneration), GO:0046683 (response to organophosphorus), GO:0051591 (response to cAMP), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0061008 (hepaticobiliary system development), GO:0097421 (liver regeneration), GO:0014074 (response to purine-containing compound), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Zinc finger E-box binding homeobox 2 (A0A8I6A027)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
Sequence: MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDAGSETDEEDKLHIAEDDGIANPLDQETSPASMPNHESSPHMSQGLLPREEEEDEIRESVVEHSWHSGEILQASVDGPDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGT
InterPro domains: - IPR051574: Zinc finger E-box-binding homeobox (family) [78-219]
- IPR008598: Di19, zinc-binding domain (domain) [124-175]
- IPR013087: Zinc finger C2H2-type (domain) [124-220]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [124-219]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001217 (DNA-binding transcription repressor activity), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Proline dehydrogenase (B4F7D0)
Organism: Rattus norvegicus (Rat)
Function: Converts proline to delta-1-pyrroline-5-carboxylate
Subcellular location: Mitochondrion matrix
Sequence: AVDTKLEVAVLQESIAKMGISSRAEIERWFTPETLGVSGTVDLLDWNSLIDSRTQLSRHLVVPNVQTGQLEPLLSRFTEEEEQQMKRMLQRMDVLAKRAREAGVRLMIDAEQSYFQPAISRLTLEMQRRFNVDKPFIFNTFQCYLKDAYDNVTIDMELSRREGWCFGAKLVRGAYMAQERARAVEIGYEDPINPTYEATNAMYHRCLNYVLEELKHSTKAEVMVASHNEDTVSFTLCRMKELGLHPADGQVCFGQLLGMCDQISFPLGQAGFPVYKYVPYGPVMEVLPYLSRRALENSSIMKGAQRERQLLWQELCRRLRTGSLFHHPA
InterPro domains: - IPR015659: Proline oxidase family (family) [5-319]
- IPR002872: Proline dehydrogenase domain (domain) [65-301]
- IPR029041: FAD-linked oxidoreductase-like (homologous_superfamily) [79-328]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0043168 (anion binding), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0043177 (organic acid binding), GO:0016649 (oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor), GO:0031406 (carboxylic acid binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009063 (amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009065 (glutamine family amino acid catabolic process), GO:0006560 (proline metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cardiac titin adult N2BA isoform (Q5VJM3)
Organism: Rattus norvegicus (Rat)
Sequence: YKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLEMKPPDIPDSRVPIPTMPIRAVPPEEIPPAVAPSIPLLLPLPEEKKPPAKRIEVTKKGVKKDTKKVVAKPKEEAPPPPPVPEVAKKPPPPTPMIPAKPSEIIDVSSKAEEVKITTITRKKEIHKEKEAVYERKEAVYEKKVLIEPWEEPYEELETEPYTEPYEEPYYEEPDEDYEEIKVEAKKEVHEEWEEDYEEGQEYYEREEGYDEGEEEWEEIYHEREIIQVQKEVHEDLHEKKIPAKVPEKKVPPPKVPEAPKKPAPEEKTAVPVAKKKEAPPPKVLEEPEEYVVEEKLHVISKRVEVEPAKVPEKHEKKIIPRPKVPAKIEEPPPTKVPEVPKKPVPEEKAPVPVPKKVEPPPAKVPEVPKKPVPEKKVPAPTPKKVEAPPAKAPEVPPKEVTPEKKVPVVPPKKPEAPPPKVPTAEKKVRKLLPEPKPQPKEEVVLKSVLRKRPEEEEPKVEPKKVEKVKKPEEPPPPPKAVEVEAPPEPKPKERKVPEPTKVPEIKPAIPLPGPEPKPKPEPEVKTMKAPPIEPAPTPIAAPVTAPVVGKKAEAKPKDEAAKPKGPIKGVAKKTPSPIEAERKKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIVLTE
InterPro domains: - IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-67]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [1-57]
- IPR004168: PPAK motif (repeat) [340-447]
- IPR013098: Immunoglobulin I-set (domain) [2-55]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019900 (kinase binding), GO:0003779 (actin binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Intraflagellar transport 88 (A0A096MJE9)
Organism: Rattus norvegicus (Rat)
Sequence: MGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWL
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0035869 (ciliary transition zone), GO:0036064 (ciliary basal body), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)
Protein: T-box transcription factor 1 (D4A2E9)
Organism: Rattus norvegicus (Rat)
Subcellular location: Nucleus
Sequence: MHFSTVTRDMEAFAASSLSGLGAPSPGADPFGPREPPPPRYDPCTAAPGAPGPPPPPRAYPFAPAPGAASSSAAESEGPGASRAAAAKAPVKKNPKVASVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLVSAFARSRNPVASPTQPNGADKDVAEARREFDRDSGPAALGDATHPPQLLARVLSPALPGPGGLVPLPGGSGGRHSPPHADLRLEAPGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHAHPHHHHHPAVNPAAAAAAAAAANVYSSAAAPPGAYDYCPR
InterPro domains: - IPR036960: T-box superfamily (homologous_superfamily) [88-287]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [100-287]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [109-203]
- IPR046360: T-box transcription factor, DNA-binding domain (domain) [99-292]
- IPR001699: T-box transcription factor (family) [61-466]
Interaction partners: - Transmembrane protein 26
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0060485 (mesenchyme development), GO:0060541 (respiratory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Ceramide synthase 5 (D4AA91)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus
Sequence: MATAAAEALGLLWGWLWSGRFWLPQNVSWADLEGPGDGYGYPRARHVLSVFPLAAGLFSVRMLFERFIAKPCALRIGIEDSAVYQVESNVTLEKVFTSISKYPDEKRLKGLSKQLDWDVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYFCIFCYGVRFLWSMPWLWDTRQCWYNYPYQPLSRELYYYYLTQLAFYWSLVFSQFIDVKRKDFLMMFMHHLIAVTLISFSYINNMVRVGAIILCLHDSADSLLEAAKLANYARQERLCNTLFVIFGAAFMVTRLGIFPLWILNTTLFESWEIIGPFPSWWLFNGLLLILQMLHVIWSYLIARTAFKALVRGKVTYPGGISPGSVPSALFSPPSSFLCLVAAGQSHPLHVSKDDRSDVESSSEEDETTHTNNLSGSSSSNGANCMNGRMGGSHLAEEQGTCKAAGNLHFGASPRIHSCD
InterPro domains: - IPR016439: Sphingosine N-acyltransferase Lag1/Lac1-like (family) [9-412]
- IPR001356: Homeodomain (domain) [90-136]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [82-134]
- IPR006634: TRAM/LAG1/CLN8 homology domain (domain) [139-340]
Interaction partners: - 3-ketodihydrosphingosine reductase
- Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
- Sphingolipid delta(4)-desaturase DES1
- Acid ceramidase
- Alkaline ceramidase
- Sphingomyelin phosphodiesterase 2
- Neutral ceramidase
- Alkaline ceramidase
- Ceramide glucosyltransferase
- Ceramide kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0048545 (response to steroid hormone), GO:0032870 (cellular response to hormone stimulus), GO:0014070 (response to organic cyclic compound), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0071383 (cellular response to steroid hormone stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Forkhead box protein H1 (B0BN92)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)
Subcellular location: Nucleus
Sequence: TLSPQLVQALAQGYIPCMGPLDNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYRPPSPPPPSREDFSIKSLLGDPGKASTWPQHPRLAGQSTPAQASTLSKGEEGIGAGPSNVSDKPLWPLSSLPRPTRIEGETSQGEVIRPSPVSSDQGSWPLHLLQDSSDSMGMSRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPPTSCPRCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM
InterPro domains: - IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [36-126]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [49-119]
- IPR001766: Fork head domain (domain) [48-135]
- IPR052327: Activin-responsive transcriptional regulator (family) [12-373]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [80-86]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)