wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase (EC 2.4.1.297) (3-O-glucoside-2''-O-glucosyltransferase) (In3GGT) (Protein dusky) (Dy) (Q53UH4)
Organism: Ipomoea nil (Japanese morning glory) (Pharbitis nil)
Function: Glycosyltransferase that mediates the glucosylation of anthocyanidin 3-O-glucosides to yield anthocyanidin 3-O-sophorosides. 3-O-sophoroside derivatives are required for the bright blue or red color of flowers.
Sequence: MGSQATTYHMAMYPWFGVGHLTGFFRLANKLAGKGHRISFLIPKNTQSKLESFNLHPHLISFVPIVVPSIPGLPPGAETTSDVPFPSTHLLMEAMDKTQNDIEIILKDLKVDVVFYDFTHWLPSLARKIGIKSVFYSTISPLMHGYALSPERRVVGKQLTEADMMKAPASFPDPSIKLHAHEARGFTARTVMKFGGDITFFDRIFTAVSESDGLAYSTCREIEGQFCDYIETQFQKPVLLAGPALPVPSKSTMEQKWSDWLGKFKEGSVIYCAFGSECTLRKDKFQELLWGLELTGMPFFAALKPPFEAESIEAAIPEELKEKIQGRGIVHGEWVQQQLFLQHPSVGCFVSHCGWASLSEALVNDCQIVLLPQVGDQIINARIMSVSLKVGVEVEKGEEDGVFSRESVCKAVKAVMDEKSEIGREVRGNHDKLRGFLLNADLDSKYMDSFNQKLQDLLG
InterPro domains: - IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [8-420]
- IPR050481: UDP-glycosyltransferase, plant-type (family) [9-451]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016763 (pentosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0035252 (UDP-xylosyltransferase activity), GO:0042285 (xylosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042440 (pigment metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0046283 (anthocyanin-containing compound metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046148 (pigment biosynthetic process), GO:0009718 (anthocyanin-containing compound biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: GH16843p (Q8I941)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSSEELAPINEQDFKDLKERMKLIVEADPKQYHNDFSLRRYLRAFKTTDDAFQAILKTNKWRETYGVDKLSEMDRSQLDKKARLLRHRDCIGRPVIYIPAKNHSSERDIDELTRFIVYNLEEACKKCFEEVTDRLCIVFDLAEFSTSCMDYQLVQNLIWLLGKHFPERLGVCLIINSPGLFSTIWPAIRVLLDDNTAKKVKFVADEAELCQYLIPDILPTDM
InterPro domains: - IPR036273: CRAL/TRIO, N-terminal domain superfamily (homologous_superfamily) [5-71]
- IPR052432: Phosphatidylinositol transfer protein/CRAL-TRIO domain (family) [29-222]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [2-222]
- IPR001251: CRAL-TRIO lipid binding domain (domain) [72-222]
Interaction partners: - Golgin 104
- FI01459p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051606 (detection of stimulus), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0009581 (detection of external stimulus), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0009314 (response to radiation), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0009582 (detection of abiotic stimulus), GO:0007602 (phototransduction), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009416 (response to light stimulus), GO:0007603 (phototransduction, visible light), GO:0046486 (glycerolipid metabolic process), GO:0006643 (membrane lipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0009583 (detection of light stimulus), GO:0009639 (response to red or far red light), GO:0009584 (detection of visible light)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Shewanella-like protein phosphatase 2 (EC 3.1.3.16) (Q8I5Y5)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MNISYLRNFSCIYFLIIIWKFSYVYNESYSNIKWEHDLFSISDLHSDLDALKKTLLTENIIDEENNAIRENVFVIITGDVLDPAYDDIEILYFIQNYNIKAKPLNSKIQLILGNHEVQNICLDFIGNKKYGEEYKARNKLFKKGEVLYNYLLDLPFVIKVNDILFSHASILPYYAKRGIDYINDEGRSEIKNNCTLLKFKRKTGQRFCVCCYNGPTFNRYFSRAAEMPFRREVCKSLFKTLNKLSAKKLVNGHTIQRNRKVNEYCKGGLIMADTGISKWKYGVINYVQYFQDGSYKVNYINSDI
InterPro domains: - IPR004843: Calcineurin-like, phosphoesterase domain (domain) [41-254]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [8-301]
Interaction partners: - Protein phosphatase inhibitor 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044248 (cellular catabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0044275 (cellular carbohydrate catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0044242 (cellular lipid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0016042 (lipid catabolic process), GO:0006643 (membrane lipid metabolic process), GO:0016311 (dephosphorylation), GO:0030149 (sphingolipid catabolic process), GO:0019377 (glycolipid catabolic process), GO:0006664 (glycolipid metabolic process), GO:0006687 (glycosphingolipid metabolic process), GO:0046466 (membrane lipid catabolic process), GO:0046479 (glycosphingolipid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)
Protein: Cyclin-D5-3 (G1/S-specific cyclin-D5-3) (CycD5;3) (Q10QA2)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Not known
Sequence: MGDASASTSAPATPTSTLICREDGNDLFSADPADDDGGGGSGGDWELSIADDDHVLLMDRDDEYLALMLSKERCAGGGGGGERGDEEEEEMVEEWMKNARAWCVGWIVKTNAGFRFSLKTAYVAVTYLDRFLARRCVDRDKEWALQLLSVACLSLAAKVEERRPPRLPEFKLDMYDCASLMRMELLVLTTLKWQMITETPFSYLNCFTAKFRHDERKAIVLRAIECIFASIKVISSVGYQPSTIALAAILIARNKETAPNLDELKSVVGSLWQQLDTGHVYSCYNKMMIQEDRSMQSTTEVASSGVSVAHIGGSEDSAMGGANNATTLEATPDKKRKRLHSPQRQ
InterPro domains: - IPR013763: Cyclin-like domain (domain) [105-189]
- IPR039361: Cyclin (family) [67-288]
- IPR006671: Cyclin, N-terminal (domain) [96-195]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [94-195]
Interaction partners: - Retinoblastoma-related protein 2
- Retinoblastoma-related protein 1
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase A-1
- Proliferating cell nuclear antigen
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinases regulatory subunit 1
- Os05g0483900 protein
- [RNA-polymerase]-subunit kinase
- Os05g0484000 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0048608 (reproductive structure development), GO:0010374 (stomatal complex development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0010440 (stomatal lineage progression), GO:0090558 (plant epidermis development), GO:0061458 (reproductive system development), GO:1905421 (regulation of plant organ morphogenesis), GO:0090627 (plant epidermal cell differentiation), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Peroxin 11 (RE39562p) (Q7JZE1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Sequence: MDQLVQLNNQAGGRDKIARLIQYASRAMWDSLESANSNPALVDNFKTVEYILSTFRKLLRFGKCVDVFYGALKTIHHPDLNIRVTLTLSKLSQSLFLFADHFLWLARTGLTAVNAKRWSNIANKYWLFSIIMNLCRDFYEILRVLDLHRSGSKSGISRCRIPASINSPEDFKRLALQSYVLMQGHKDIVVDTVKNACDFFIPLTALGYTSLTPRTIGLLGAISSLAGLWALLEPRAKLTPA
InterPro domains: - IPR008733: Peroxisomal biogenesis factor 11 (family) [1-231]
Interaction partners: - Peroxin-19
- Peroxisomal membrane protein PEX13
- Peroxin 11c, isoform B
- Peroxisome assembly protein 12
- Peroxisomal membrane protein PEX14
- FI14123p
- Peroxisomal biogenesis factor 3
- Peroxisomal membrane protein PEX16
- RING-type E3 ubiquitin transferase
- Peroxisomal targeting signal 1 receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0016043 (cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0006996 (organelle organization), GO:0032535 (regulation of cellular component size), GO:0007031 (peroxisome organization), GO:0048285 (organelle fission), GO:0016559 (peroxisome fission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (P60521)
Organism: Mus musculus (Mouse)
Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).
Subcellular location: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:14530254}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P60520}. Golgi apparatus {ECO:0000250|UniProtKB:P60519}.
Sequence: MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF
InterPro domains: - IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-116]
- IPR004241: Autophagy protein Atg8 ubiquitin-like (family) [2-116]
Interaction partners: - Ubiquitin-like modifier-activating enzyme ATG7
- Ubiquitin-like-conjugating enzyme ATG3
- Cysteine protease ATG4B
- Sequestosome-1
- Ubiquitin-like protein ATG12
- Next to BRCA1 gene 1 protein
- Calcium-binding and coiled-coil domain-containing protein 2
- Cysteine protease ATG4A
- Autophagy protein 5
- Beclin 1-associated autophagy-related key regulator
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0005776 (autophagosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005764 (lysosome), GO:0097014 (ciliary plasm), GO:0044754 (autolysosome), GO:0005767 (secondary lysosome)
Protein: Protein phosphatase inhibitor 2 (IPP-2) (P11845)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Inhibitor of protein-phosphatase 1.
Sequence: MAASTASHRPIKGILKNKTSSTSSRVASAEQPRGSVDEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMIGDDDDAYSDTETTEAMTPDTLAKKLAAAEGSEPKYRIREQESSGEEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLHDDEEDEEMSETADGESMNTEESNQGSTPSDQRQNKSQSS
InterPro domains: - IPR007062: Protein phosphatase inhibitor 2 (IPP-2) (family) [12-188]
Interaction partners: - Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
- Serine/threonine-protein phosphatase
- Lysozyme E
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0019899 (enzyme binding), GO:0004857 (enzyme inhibitor activity), GO:0019208 (phosphatase regulator activity), GO:0019902 (phosphatase binding), GO:0019888 (protein phosphatase regulator activity), GO:0019212 (phosphatase inhibitor activity), GO:0004864 (protein phosphatase inhibitor activity), GO:0019903 (protein phosphatase binding), GO:0008157 (protein phosphatase 1 binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0010921 (regulation of phosphatase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0043666 (regulation of phosphoprotein phosphatase activity), GO:0035303 (regulation of dephosphorylation), GO:0035304 (regulation of protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) (Q9JKE3)
Organism: Rattus norvegicus (Rat)
Function: Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Recycling endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium-triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.
Sequence: MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHLSLTKRLYYLWMLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSSFSFMAFFFTFMAQLVISIIQAVGIPGWGVCGWIATISFFGTNIGSAVVMLIPTVMFTVVAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQPQTQYSTTPNYTYSNEM
InterPro domains: - IPR007273: SCAMP (family) [3-202]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0072599 (establishment of protein localization to endoplasmic reticulum), GO:0045047 (protein targeting to ER), GO:0070972 (protein localization to endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78) (P52888)
Organism: Homo sapiens (Human)
Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P47788}.
Sequence: MKPPAACAGDMADAASPCSVVNDLRWDLSAQQIEERTRELIEQTKRVYDQVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNEDTTFLPFTLQELGGLPEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKRAECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC
InterPro domains: - IPR024080: Neurolysin/Thimet oligopeptidase, N-terminal (homologous_superfamily) [16-151]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [361-511]
- IPR045090: Peptidase M3A/M3B (family) [12-678]
- IPR001567: Peptidase M3A/M3B catalytic domain (domain) [227-675]
- IPR024077: Neurolysin/Thimet oligopeptidase, domain 2 (homologous_superfamily) [159-672]
Interaction partners: - Kininogen-1
- Calmodulin-1
- Prolyl endopeptidase
- Syntaxin-6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006518 (peptide metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)