Protein: Protein inhibitor of activated STAT 2 (A0A087WUY7)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus speckle
Sequence: HMAVPFYIPTSNVWSDPVSQHPRQHLVLSVFFILAILNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGFVNL
InterPro domains: - IPR036361: SAP domain superfamily (homologous_superfamily) [34-94]
- IPR023321: PINIT domain (domain) [163-328]
- IPR038654: PINIT domain superfamily (homologous_superfamily) [174-327]
- IPR004181: Zinc finger, MIZ-type (domain) [360-441]
- IPR003034: SAP domain (domain) [39-74]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [328-456]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0019789 (SUMO transferase activity), GO:0140297 (DNA-binding transcription factor binding), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0061665 (SUMO ligase activity), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0051246 (regulation of protein metabolic process), GO:0097696 (receptor signaling pathway via STAT), GO:0051247 (positive regulation of protein metabolic process), GO:0031399 (regulation of protein modification process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0007259 (receptor signaling pathway via JAK-STAT), GO:0031401 (positive regulation of protein modification process), GO:0018193 (peptidyl-amino acid modification), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0018205 (peptidyl-lysine modification), GO:0032446 (protein modification by small protein conjugation), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:0033235 (positive regulation of protein sumoylation), GO:0016925 (protein sumoylation), GO:0033233 (regulation of protein sumoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)