Protein: Kinesin-related protein 6 (Kinesin family member 6) (Kinesin-13) (Q6S004)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Sequence: MDFENDQLYNWLQLANLESFYPNFIKKNVSCDSFLSFTMQDYGNVGITSLQDRKKLFHLLQQLKKQTPPISNTSSPVINSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSSGLRQPTSTSSLLSNNNLMSTQTQQSSSSSSSSSLSSKSNSNSDFMQKAQQLLKQRELERQQYAKQQQQQQSTQTKYQSSLKDFDITSSNKNNNLDDFFEDDNLYSQQQQQQQQQQQQQDFEFEEEEEEEDQQQQYDEEEEEEEEYEEDFYKEDLGEIDDGNVLDISDDEPDPNSSCIIVEGSPDEEDDDVEYIPQNESLVNGFGSMKIQQQQQQQFQPLQQQQQQQQQQQQQFYQQQIQQQQQQQQQQQQQQVQQQQQQFNNFNYSGLNEEQIKYYQQQAQYQQQVQQAQQAAIQQAQQAAALAQASQQQLQQQEQQRQQASNFFLDMNEYGQRIRVCVRKRPLNKKEIAKSEKDIIEVLPKKDLIVNEPKTKLDLSKFIEKHKFTFDGVFDESANNYQVYLHTAYPLVDSIFHKGKATCFAYGQTGSGKTHTQMGQQGDGLYALAARDIFHRLETYFKDQLQVCISFFEIYGGKLFDLLNERKKLACRENELQNVVIVGLSEKHVTSPQELMNCIIDGNKIRSTGSTGVNSDSSRSHAILQISLKNIKTNKLHGKFSFIDLAGSERGSDTYDNDKQTRKEGADINKSLLALKECIRALDQSSKHTPFRQSTLTQVLKDSFVGNSRTVMIANISPNQSSSEHTLNTLRYADRVKELGTSESNSNKKPVATYNIPAPLPPPDHLKQNFNDPILIPSTTTTTTTTATAINSQQPIIQQTSQPVSKIKQPVKQQQESQIPQTPQQQQQQQPPQQQPQQQQYNIPQTPQQTQQQFNIPQTPKQQQPIQTQPPMSPPKIDFVNYHRNHVDQFADILKKELISINQFESSKGSIPLENYINNIEQFLDSKQLLINHLRGIIQQHQQQPIQQQQQQQQPIQQQQQSTPQPSQLQTPQQRERARSQLQPPKPSIYSSRN
InterPro domains: - IPR001660: Sterile alpha motif domain (domain) [3-66]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [2-68]
- IPR027640: Kinesin-like protein (family) [403-894]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [674-685]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [437-774]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [425-774]
- IPR001752: Kinesin motor domain (domain) [451-783]
Interaction partners: - Aurora kinase
- Kinesin-related protein 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0003777 (microtubule motor activity), GO:0005515 (protein binding), GO:0008574 (plus-end-directed microtubule motor activity), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006996 (organelle organization), GO:0031122 (cytoplasmic microtubule organization), GO:0097435 (supramolecular fiber organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005819 (spindle), GO:0005634 (nucleus), GO:0005874 (microtubule), GO:0005876 (spindle microtubule), GO:0015630 (microtubule cytoskeleton), GO:0005828 (kinetochore microtubule)