Protein: Vacuolar heme ABC transmembrane exporter abc3 (Q9P5N0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Iron-regulated vacuolar transporter that mobilizes stored heme from the vacuole to the cytosol in response to iron deficiency.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16849797, ECO:0000269|PubMed:19915076, ECO:0000269|PubMed:28193844}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16849797, ECO:0000269|PubMed:19915076, ECO:0000269|PubMed:28193844}.
Sequence: MITANKGLSLVLLIPNLFALVSGGLQYVFDVRRRIFRPHFSQFWTIWMKFFSIALVIITQIYVGYKTKNIGWNFFSVVTYCFVLFLQFAEQSTLRVPMASLLIFWLLKVVTSLLILLFSPYIAITSMARLLTLITLFCSLVCFISEVYVPPCNRVWYSDDTNEVEEKGIRPSEVRYANIFSKLSFSWISSFIKFGYTNYLKESDVWLLPPDERSGNLIIGFEDWWIYHSKNKRRSLFLWKLLFFNHWKLVALITITKLIQDVLAFVQPTLIQKTILFISSYTSPNPESPSRGFIIAILVLVANFLQTLLLQQYNQLIMLLGMRWKTELLASIYRKSLLLSSSARQNRSIGDIINYMAVDTQKISDLPIYLFIIVSGPFQIALALSNLYHLMGYSAFTGVAASVILFPCNIIVANVYKKFQSILMKNKDSRSKLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELSMLKKIGFITAIGDFAWIFTTIIVTTVAFGAFIIFHGKTQALTADIVFPAVSLFNLLQFPLAMLPTVISSLLEASVSVSRIYEFLIAQELDYNGVQRFPATEIPHEICLEIKSGTFSWSKKTLKQQVTPTLRQINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGSLAYAAQQPWIFDATIRENILFGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQKSRISLARAIYSQADIYLLDDVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLNVLKEADSIYILSNGKIVEKGNYEHLFVSTNSELKQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHVEGLETYSSSERKDSSNKYKSRKRNPIRQKVTEDDKGKCVAQTDELVQRGKVKWHVYWMYFKSCSIGLILLYFFFIISGIMMNVATNVWLKHWSEENGKSSSELNPSPYFYLGIYLFFGFLSCAFISSSSLTMTVLCGIRSGRYLHDSMLKTILRAPMGFFETTSSGRILNRFSNDVYKVDEVVSLTFMFFFRNSIQVLFILGVICYSAPLSLLLIVPLFFLYLYNRAYYVRTSRELKRLDNVTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMFFSSSRWQAIRVECIGDLIIFCTAFYGILSAIKGSPNPGLVGFSLSYAIQITQGLSFIVQQSVDAENNTVSVERILEYINVKSEAPEIIPENRPPCEWPTDGAVSFNHYSAKYREDLSFALNNINIEISPREKIGIVGRTGAGKSTLAMALFRIIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGNIRENLDPNHRLTDKKIWEVLEIASLKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARVLLTSTRILLLDEATASVHAETDAIVQQTIRKRFKDRTILTVAHRINTVMDSDRILVLDHGKVVEFDATKKLLENKDSMFYSLAKESGLI
InterPro domains: - IPR017871: ABC transporter-like, conserved site (conserved_site) [704-1377]
- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [228-1207]
- IPR003593: AAA+ ATPase domain (domain) [606-1437]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [558-1460]
- IPR044726: ABC transporter C family, six-transmembrane helical domain 2 (domain) [903-1201]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [575-1460]
- IPR050173: ATP-binding cassette transporter C-like (family) [176-1462]
- IPR011527: ABC transporter type 1, transmembrane domain (domain) [251-1189]
Interaction partners: - ATP-binding cassette transporter abc2
- Iron transport multicopper oxidase fio1
- Ferric reductase transmembrane component 1
- Vacuolar basic amino acid transporter vsb1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140359 (ABC-type transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:1904680 (peptide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:1990748 (cellular detoxification), GO:0061687 (detoxification of inorganic compound), GO:0010035 (response to inorganic substance), GO:0035672 (oligopeptide transmembrane transport), GO:0034486 (vacuolar transmembrane transport), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009636 (response to toxic substance), GO:0071585 (detoxification of cadmium ion), GO:0097501 (stress response to metal ion), GO:1990170 (stress response to cadmium ion), GO:0010038 (response to metal ion), GO:0097237 (cellular response to toxic substance), GO:0071705 (nitrogen compound transport), GO:0071241 (cellular response to inorganic substance), GO:0071702 (organic substance transport), GO:0071248 (cellular response to metal ion), GO:0042886 (amide transport), GO:0015833 (peptide transport), GO:0015711 (organic anion transport), GO:0046686 (response to cadmium ion), GO:0006857 (oligopeptide transport), GO:0034635 (glutathione transport), GO:0071276 (cellular response to cadmium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole), GO:0098852 (lytic vacuole membrane), GO:0000329 (fungal-type vacuole membrane)