Protein: Prostaglandin E2 receptor EP4 subtype (Prostanoid EP4 receptor) (Q2N1D9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MEPTVPTIPAIMFIFGVISNLIAIVVLCKSRREQKETTFYTLVCGLAVTDLLGTVLASPVTIATYVKGAWPDGDPLCQYFGFVLLFFSLAGLSIICAMSIERYIAINHAYFYNDYVDKRLAGVTLLAIYASNILFCALPSVGFGEVKMQYPQTWCFIDWRTNVSAHAAFSYMYAGCSSLLILVTVVCNVLVCGALIRMHRRFVRRTSLGTDPQRAADPGRSRSFSRLAGAEIQMVILLIATSAVVLICSIPLVVQVFLNQLYKTPVEKRLDKNPDLLAIRFASTNPILDPWIYILLRKAVLSKVVENIKCLFCRSDSRGQQTQNSLLCINGQQFSSRDSPSGVSRELQDVSSTSQTSLNLAKAPAGGQNSSSESCRCSSHDGQCKKQSLQMSITNDSVQEKSI
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [19-293]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [4-301]
- IPR001244: Prostaglandin DP receptor (family) [7-187]
- IPR008365: Prostanoid receptor (family) [9-353]
- IPR001758: Prostanoid EP4 receptor (family) [28-214]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0004953 (icosanoid receptor activity), GO:0004954 (prostanoid receptor activity), GO:0004955 (prostaglandin receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0003012 (muscle system process), GO:1901698 (response to nitrogen compound), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009891 (positive regulation of biosynthetic process), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0031326 (regulation of cellular biosynthetic process), GO:1901699 (cellular response to nitrogen compound), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0019932 (second-messenger-mediated signaling), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1901699 (cellular response to nitrogen compound), GO:0006355 (regulation of DNA-templated transcription), GO:0019722 (calcium-mediated signaling), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)