Protein: BOS complex subunit NOMO1 (Q15155)
Organism: complex subunit NOMO1 {ECO:0000305};
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein
Sequence: MLVGQGAGPLGPAVVTAAVVLLLSGVGPAHGSEDIVVGCGGFVKSDVEINYSLIEIKLYTKHGTLKYQTDCAPNNGYFMIPLYDKGDFILKIEPPLGWSFEPTTVELHVDGVSDICTKGGDINFVFTGFSVNGKVLSKGQPLGPAGVQVSLRNTGTEAKIQSTVTQPGGKFAFFKVLPGDYEILATHPTWALKEASTTVRVTNSNANAASPLIVAGYNVSGSVRSDGEPMKGVKFLLFSSLVTKEDVLGCNVSPVPGFQPQDESLVYLCYTVSREDGSFSFYSLPSGGYTVIPFYRGERITFDVAPSRLDFTVEHDSLKIEPVFHVMGFSVTGRVLNGPEGDGVPEAVVTLNNQIKVKTKADGSFRLENITTGTYTIHAQKEHLYFETVTIKIAPNTPQLADIIATGFSVCGQISIIRFPDTVKQMNKYKVVLSSQDKDKSLVTVETDAHGSFCFKAKPGTYKVQVMVPEAETRAGLTLKPQTFPLTVTNRPMMDVAFVQFLASVSGKVSCLDTCGDLLVTLQSLSRQGEKRSLQLSGKVNAMTFTFDNVLPGKYKISIMHEDWCWKNKSLEVEVLEDDMSAVEFRQTGYMLRCSLSHAITLEFYQDGNGRENVGIYNLSKGVNRFCLSKPGVYKVTPRSCHRFEQAFYTYDTSSPSILTLTAIRHHVLGTITTDKMMDVTVTIKSSIDSEPALVLGPLKSVQELRREQQLAEIEARRQEREKNGNEEGEERMTKPPVQEMVDELQGPFSYDFSYWARSGEKITVTPSSKELLFYPPSMEAVVSGESCPGKLIEIHGKAGLFLEGQIHPELEGVEIVISEKGASSPLITVFTDDKGAYSVGPLHSDLEYTVTSQKEGYVLTAVEGTIGDFKAYALAGVSFEIKAEDDQPLPGVLLSLSGGLFRSNLLTQDNGILTFSNLSPGQYYFKPMMKEFRFEPSSQMIEVQEGQNLKITITGYRTAYSCYGTVSSLNGEPEQGVAMEAVGQNDCSIYGEDTVTDEEGKFRLRGLLPGCVYHVQLKAEGNDHIERALPHHRVIEVGNNDIDDVNIIVFRQINQFDLSGNVITSSEYLPTLWVKLYKSENLDNPIQTVSLGQSLFFHFPPLLRDGENYVVLLDSTLPRSQYDYILPQVSFTAVGYHKHITLIFNPTRKLPEQDIAQGSYIALPLTLLVLLAGYNHDKLIPLLLQLTSRLQGVRALGQAASDNSGPEDAKRQAKKQKTRRT
InterPro domains: - IPR056187: NOMO, eighth prealbumin-like domain (domain) [746-798]
- IPR051417: Serine-Aspartate Repeat-Containing (family) [44-1213]
- IPR041033: SpaA-like, prealbumin fold domain subgroup 1 (domain) [874-955]
- IPR013784: Carbohydrate-binding-like fold (homologous_superfamily) [127-954]
- IPR055073: NOMO-like, ninth beta-sandwich domain (domain) [799-873]
- IPR056189: NOMO, third transthyretin-like domain (domain) [226-325]
- IPR008969: Carboxypeptidase-like, regulatory domain superfamily (homologous_superfamily) [964-1053]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [122-226]
- IPR055075: NOMO-like, N-terminal beta-sandwich domain (domain) [40-124]
- IPR056319: NOMO, seventh transthyretin-like domain (domain) [592-664]
- IPR056190: NOMO, fifth transthyretin-like domain (domain) [409-498]
- IPR055074: NOMO, second beta-sandwich domain (domain) [126-581]
- IPR056191: NOMO, C-terminal transthyretin-like domain (domain) [1054-1147]
Interaction partners: - BOS complex subunit NCLN
- Pyridoxal-dependent decarboxylase domain-containing protein 1
- Bifunctional apoptosis regulator
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0043021 (ribonucleoprotein complex binding), GO:0043022 (ribosome binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0070206 (protein trimerization), GO:0070207 (protein homotrimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)