Protein: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A, B subunit, B' delta isoform) (Protein RTS1) (Protein SCS1) (P38903)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7565713}. Nucleus {ECO:0000269|PubMed:7565713}.
Sequence: MMRGFKQRLIKKTTGSSSSSSSKKKDKEKEKEKSSTTSSTSKKPASASSSSHGTTHSSASSTGSKSTTEKGKQSGSVPSQGKHHSSSTSKTKTATTPSSSSSSSRSSSVSRSGSSSTKKTSSRKGQEQSKQSQQPSQSQKQGSSSSSAAIMNPTPVLTVTKDDKSTSGEDHAHPTLLGAVSAVPSSPISNASGTAVSSDVENGNSNNNNMNINTSNTQDANHASSQSIDIPRSSHSFERLPTPTKLNPDTDLELIKTPQRHSSSRFEPSRYTPLTKLPNFNEVSPEERIPLFIAKVDQCNTMFDFNDPSFDIQGKEIKRSTLDELIEFLVTNRFTYTNEMYAHVVNMFKINLFRPIPPPVNPVGDIYDPDEDEPVNELAWPHMQAVYEFFLRFVESPDFNHQIAKQYIDQDFILKLLELFDSEDIRERDCLKTTLHRIYGKFLSLRSFIRRSMNNIFLQFIYETEKFNGVAELLEILGSIINGFALPLKEEHKVFLVRILIPLHKVRCLSLYHPQLAYCIVQFLEKDPLLTEEVVMGLLRYWPKINSTKEIMFLNEIEDIFEVIEPLEFIKVEVPLFVQLAKCISSPHFQVAEKVLSYWNNEYFLNLCIENAEVILPIIFPALYELTSQLELDTANGEDSISDPYMLVEQAINSGSWNRAIHAMAFKALKIFLETNPVLYENCNALYLSSVKETQQRKVQREENWSKLEEYVKNLRINNDKDQYTIKNPELRNSFNTASENNTLNEENENDCDSEIQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [291-708]
- IPR002554: Protein phosphatase 2A, regulatory B subunit, B56 (family) [1-757]
- IPR011989: Armadillo-like helical (homologous_superfamily) [284-711]
Interaction partners: - Protein phosphatase PP2A regulatory subunit B
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Protein phosphatase PP2A regulatory subunit A
- Shugoshin
- Spindle assembly checkpoint serine/threonine-protein kinase BUB1
- Protein phosphatase methylesterase 1
- Serine/threonine-protein phosphatase 4 catalytic subunit
- Serine/threonine-protein phosphatase PP1-1
- Spindle assembly checkpoint component MAD3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0051179 (localization), GO:0007267 (cell-cell signaling), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0051640 (organelle localization), GO:0016043 (cellular component organization), GO:0099536 (synaptic signaling), GO:0051648 (vesicle localization), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0034330 (cell junction organization), GO:0097479 (synaptic vesicle localization), GO:0099537 (trans-synaptic signaling), GO:0050808 (synapse organization), GO:0098916 (anterograde trans-synaptic signaling), GO:0007528 (neuromuscular junction development), GO:0007268 (chemical synaptic transmission), GO:0007274 (neuromuscular synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1903293 (phosphatase complex), GO:0008287 (protein serine/threonine phosphatase complex), GO:0000159 (protein phosphatase type 2A complex)