Protein: E3 ubiquitin-protein ligase TRIM15 (Q9C019)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Also plays a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8- mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm. Also plays an important regulatory effect on the activation of hepatic stellate cells (HSCs)
Subcellular location: Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=Localizes to focal adhesions during the early stage of adhesion biogenesis
Sequence: MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG
InterPro domains: - IPR003879: Butyrophylin-like, SPRY domain (domain) [292-454]
- IPR001841: Zinc finger, RING-type (domain) [16-61]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [296-459]
- IPR000315: B-box-type zinc finger (domain) [78-119]
- IPR018957: Zinc finger, C3HC4 RING-type (domain) [16-60]
- IPR006574: SPRY-associated (domain) [293-345]
- IPR001870: B30.2/SPRY domain (domain) [276-465]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [31-40]
- IPR003877: SPRY domain (domain) [346-464]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [293-464]
- IPR050143: Tripartite motif-containing (family) [16-461]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [11-68]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0005488 (binding), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0003713 (transcription coactivator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048525 (negative regulation of viral process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0032103 (positive regulation of response to external stimulus), GO:0044093 (positive regulation of molecular function), GO:0048729 (tissue morphogenesis), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:1903901 (negative regulation of viral life cycle), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0045165 (cell fate commitment), GO:0001704 (formation of primary germ layer), GO:0002831 (regulation of response to biotic stimulus), GO:0001709 (cell fate determination), GO:0048598 (embryonic morphogenesis), GO:0050776 (regulation of immune response), GO:1903900 (regulation of viral life cycle), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0002833 (positive regulation of response to biotic stimulus), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0010647 (positive regulation of cell communication), GO:0031349 (positive regulation of defense response), GO:0080090 (regulation of primary metabolic process), GO:0009615 (response to virus), GO:0031347 (regulation of defense response), GO:0048333 (mesodermal cell differentiation), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051607 (defense response to virus), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0062207 (regulation of pattern recognition receptor signaling pathway), GO:0010628 (positive regulation of gene expression), GO:0060795 (cell fate commitment involved in formation of primary germ layer), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0062208 (positive regulation of pattern recognition receptor signaling pathway), GO:0140546 (defense response to symbiont), GO:0032481 (positive regulation of type I interferon production), GO:0031326 (regulation of cellular biosynthetic process), GO:0048332 (mesoderm morphogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0007498 (mesoderm development), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0039531 (regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0001710 (mesodermal cell fate commitment), GO:0044790 (suppression of viral release by host), GO:0039535 (regulation of RIG-I signaling pathway), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)