Protein: E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728) (Q9NQ86)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:28087737}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q80WG7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80WG7}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250|UniProtKB:Q80WG7}.
Sequence: MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKELLLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVPEINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [431-511]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [508-709]
- IPR027370: Zinc finger, RING-type, eukaryotic (domain) [33-59]
- IPR050617: E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins (family) [33-719]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [48-57]
- IPR017903: COS domain (domain) [356-413]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [420-509]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [15-129]
- IPR000315: B-box-type zinc finger (domain) [207-249]
- IPR003961: Fibronectin type III (domain) [419-510]
- IPR001870: B30.2/SPRY domain (domain) [495-720]
- IPR040859: Midline-1, COS domain (domain) [359-407]
- IPR035727: TRIM36, PRY/SPRY domain (domain) [515-718]
- IPR047066: E3 ubiquitin-protein ligase Trim36, B-box-type 1 zinc finger (domain) [151-205]
- IPR047065: E3 ubiquitin-protein ligase Trim36, B-box-type 2 zinc finger (domain) [210-254]
- IPR003879: Butyrophylin-like, SPRY domain (domain) [556-681]
- IPR027726: E3 ubiquitin-protein ligase Trim36, RING finger, HC subclass (domain) [28-125]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [527-714]
- IPR001841: Zinc finger, RING-type (domain) [33-118]
Interaction partners: - Centromere protein H
- Trimethyllysine dioxygenase, mitochondrial
- T-cell receptor-associated transmembrane adapter 1
- Gamma-butyrobetaine dioxygenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0008092 (cytoskeletal protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0015631 (tubulin binding), GO:0043014 (alpha-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0060627 (regulation of vesicle-mediated transport), GO:0043170 (macromolecule metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0032535 (regulation of cellular component size), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0031344 (regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0030163 (protein catabolic process), GO:0032880 (regulation of protein localization), GO:0051960 (regulation of nervous system development), GO:0036211 (protein modification process), GO:0061387 (regulation of extent of cell growth), GO:0050770 (regulation of axonogenesis), GO:0043412 (macromolecule modification), GO:0044265 (cellular macromolecule catabolic process), GO:0031345 (negative regulation of cell projection organization), GO:0010721 (negative regulation of cell development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0008361 (regulation of cell size), GO:0051603 (proteolysis involved in protein catabolic process), GO:0050771 (negative regulation of axonogenesis), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0032446 (protein modification by small protein conjugation), GO:0019941 (modification-dependent protein catabolic process), GO:0010975 (regulation of neuron projection development), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0016567 (protein ubiquitination), GO:0006513 (protein monoubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)