Protein: DNA helicase (EC 3.6.4.12) (Q9U9L0)
Organism: Trypanosoma brucei
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MADGPTQEQTKKAAFAVAATSKYPNYLADRDLCRRFFEEFRDASGGMKYMDMAARVARRETNVFTVDLDDIQLYGQLYLAQRIQMNVMGYREEVYRVVDEIIPEAYFEEDMIDHLILEAQTAGQHLPPLLTRRYELVVMPLTSFSEPVPLRQLKGGLIGTLVVLRGICIAATAVRPKLSMLVSVCEVCAETTFQQVIGDRLTPLMVCQSQRCRLNNTVGRLLPQYKASKFTKHQELRLQELPQYVPRGAIPRTIRVICEGEQTRIATPGQVVKVVGTYCPDPSTGQGHEAFRASTMVKTLFRALRIELERRSYQEAADDLKIQVDNVKQHPDKEVVIEKLTRSVAPEIWGMEDVKKALLCLLVGGSSIANGIRIRSDTNICLMGDPGVAKSQLLKWIASVAPRSIFTTGKGSSGVGLTAAVTRDTYTGEVMLEGGALVLSDRGICCIDEFDKMDDSDRTALHEVMEQQMVSIAKAGIITSLNARTSILAAANPKYGRWRRNLTPSENVNLPPALLSRFDVLWLLLDESNRERDAELSMHVTYVHLHGVAPGTVSDNGFYGLSSDYFGKDFLQAYVGEAKKIHPIVDSSAAKVISDIYCEMRAQSVRHTNVVTARTLLSIIRLSQACARLRFSDRVVEADVREAGRLLDCSKISLQERVDTGGRRMVTTSDAAIFSTIKELARSRGSIDLAEVRPALMIKGIDESHLQRCLNTYADVGVWEVSGNTVHFSLE
InterPro domains: - IPR031327: Mini-chromosome maintenance protein (family) [35-653]
- IPR027925: MCM, N-terminal domain (domain) [34-105]
- IPR033762: MCM OB domain (domain) [150-279]
- IPR041562: MCM, AAA-lid domain (domain) [569-650]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [321-667]
- IPR018525: Mini-chromosome maintenance, conserved site (conserved_site) [443-451]
- IPR001208: MCM domain (domain) [324-544]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [33-302]
- IPR008050: DNA replication licensing factor Mcm7 (family) [339-650]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0004386 (helicase activity), GO:1901363 (heterocyclic compound binding), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0003676 (nucleic acid binding), GO:0003678 (DNA helicase activity), GO:0140097 (catalytic activity, acting on DNA), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044786 (cell cycle DNA replication), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0006260 (DNA replication), GO:0006270 (DNA replication initiation), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0031974 (membrane-enclosed lumen), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0042555 (MCM complex), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0031261 (DNA replication preinitiation complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0071162 (CMG complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)