Protein: Autophagy-related protein 13 homolog (Q9VHR6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1-Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.
Subcellular location: Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.
Sequence: MSAQRLNAAERDLEKFIKFLVLKSTQVVVQSRLGEKMQTQCNPLAGSDWFNIAVQDHPEVLDETKRALNLKTGESILQRLPLCVEISLKTTEGDQMVLEVWSLDLLQPQNGASPATNDLNPEGQTLKAAHAIYNRMGIMLKSLISLTRTTPAYKLSRRQCPDSYGIFYRIYVDRPQVHTLGEGHKHVKIGQLSTIVGSLVMSVAYRTKLTISPTAAQSESNTIMLKSDHFRPATDANTPGNQQQTQNGTVVAKKLGLGALNPAQGTADRRFIDIEKPLRPGAFTDMGKLKQYTEDDFVLPETPPFEWLLRGRGSVESLNRLDNNSVASVNISNNNNSTQDSKFNQISNLNNNSAGFKSFEKNSENSVSPIKSLLIPASATATYRHHSEPSLQPPPDDDNLLKELHFPFASPTSHVNDLAKFYRECYHAPPLKGLNELQAEISSISSTPPASSGSGGVAACGPTAAATAIATSSADASAMDDLSRQLEQFETSLEDYDKLVSQFGLTGSSSTGSRSSGGLQMSN
InterPro domains: - IPR040182: Autophagy-related protein 13 (family) [10-388]
- IPR018731: Autophagy-related protein 13, N-terminal (domain) [92-208]
- IPR036570: HORMA domain superfamily (homologous_superfamily) [8-216]
Interaction partners: - RB1-inducible coiled-coil protein 1
- Autophagy-related protein 101
- Autophagy-related 1, isoform B
- Autophagy-related 14
- Autophagy-related protein 9
- Phosphatidylinositol 3-kinase catalytic subunit type 3
- Raptor, isoform B
- Autophagy-related 8a, isoform A
- non-specific serine/threonine protein kinase
- Autophagy protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060033 (anatomical structure regression), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0009791 (post-embryonic development), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0061919 (process utilizing autophagic mechanism), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009880 (embryonic pattern specification), GO:0006914 (autophagy), GO:0098542 (defense response to other organism), GO:0006793 (phosphorus metabolic process), GO:0010876 (lipid localization), GO:0051726 (regulation of cell cycle), GO:0009887 (animal organ morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0035282 (segmentation), GO:0007346 (regulation of mitotic cell cycle), GO:0010562 (positive regulation of phosphorus metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0030163 (protein catabolic process), GO:0007423 (sensory organ development), GO:0048707 (instar larval or pupal morphogenesis), GO:0090596 (sensory organ morphogenesis), GO:0060811 (intracellular mRNA localization involved in anterior/posterior axis specification), GO:0006796 (phosphate-containing compound metabolic process), GO:0007350 (blastoderm segmentation), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0044265 (cellular macromolecule catabolic process), GO:0042742 (defense response to bacterium), GO:0048569 (post-embryonic animal organ development), GO:0051247 (positive regulation of protein metabolic process), GO:0000578 (embryonic axis specification), GO:0016192 (vesicle-mediated transport), GO:0007560 (imaginal disc morphogenesis), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0007351 (tripartite regional subdivision), GO:0030182 (neuron differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0070925 (organelle assembly), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0031399 (regulation of protein modification process), GO:0065003 (protein-containing complex assembly), GO:0045937 (positive regulation of phosphate metabolic process), GO:0006468 (protein phosphorylation), GO:0120036 (plasma membrane bounded cell projection organization), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0150063 (visual system development), GO:0016310 (phosphorylation), GO:0007010 (cytoskeleton organization), GO:0042461 (photoreceptor cell development), GO:0008595 (anterior/posterior axis specification, embryo), GO:0042052 (rhabdomere development), GO:0048699 (generation of neurons), GO:0048749 (compound eye development), GO:0001745 (compound eye morphogenesis), GO:0042327 (positive regulation of phosphorylation), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0000045 (autophagosome assembly), GO:0046777 (protein autophosphorylation), GO:0019941 (modification-dependent protein catabolic process), GO:0042051 (compound eye photoreceptor development), GO:0001751 (compound eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0030427 (site of polarized growth), GO:0000922 (spindle pole), GO:0071944 (cell periphery), GO:0140535 (intracellular protein-containing complex), GO:1902494 (catalytic complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:1990234 (transferase complex), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:1990316 (Atg1/ULK1 kinase complex), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0099081 (supramolecular polymer), GO:0043025 (neuronal cell body), GO:0099081 (supramolecular polymer), GO:0043025 (neuronal cell body), GO:1990316 (Atg1/ULK1 kinase complex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0030424 (axon), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0005876 (spindle microtubule)