Protein: Urocortin-2 (Urocortin II) (Ucn II) (Q91WW1)
Organism: Rattus norvegicus (Rat)
Function: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity).
Subcellular location: Secreted.
Sequence: MTRWALVVFMVLMLDRVPGTPIPTFQLLPQNYPETTPSSVSSESPSDTTTGPSASWSNSKASPYLDTRVILSLDVPIGLLRILLEQARNKAARNQAATNAQILARVGRR
InterPro domains: - IPR024270: Urocortin II/III (family) [24-109]
- IPR000187: Corticotropin-releasing factor (domain) [71-106]
Interaction partners: - Corticotropin-releasing factor receptor 2
- Corticotropin-releasing factor receptor 1
- Urocortin
- Urocortin 3.
- Corticoliberin
- Corticotropin-releasing factor-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023056 (positive regulation of signaling), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051240 (positive regulation of multicellular organismal process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046887 (positive regulation of hormone secretion), GO:0060341 (regulation of cellular localization), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0046883 (regulation of hormone secretion), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0031668 (cellular response to extracellular stimulus), GO:0050877 (nervous system process), GO:0051222 (positive regulation of protein transport), GO:0071496 (cellular response to external stimulus), GO:0090066 (regulation of anatomical structure size), GO:1903532 (positive regulation of secretion by cell), GO:0071417 (cellular response to organonitrogen compound), GO:1901652 (response to peptide), GO:0003018 (vascular process in circulatory system), GO:0050890 (cognition), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0071310 (cellular response to organic substance), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:1901699 (cellular response to nitrogen compound), GO:0032880 (regulation of protein localization), GO:0050714 (positive regulation of protein secretion), GO:0010468 (regulation of gene expression), GO:0035150 (regulation of tube size), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0010243 (response to organonitrogen compound), GO:0090087 (regulation of peptide transport), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0072359 (circulatory system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0014070 (response to organic cyclic compound), GO:0051252 (regulation of RNA metabolic process), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0050708 (regulation of protein secretion), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0007507 (heart development), GO:0032024 (positive regulation of insulin secretion), GO:0050796 (regulation of insulin secretion), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0010959 (regulation of metal ion transport), GO:0002791 (regulation of peptide secretion), GO:1901653 (cellular response to peptide), GO:0002791 (regulation of peptide secretion), GO:0035296 (regulation of tube diameter), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0032869 (cellular response to insulin stimulus), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)