Protein: High-affinity glucose transporter 1 (A0A1D8PCL1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: High-affinity glucose transporter. Acts as a multifunctional complement-evasion molecule that causes down-regulation of complement activation by acquisition of human complement factors FH and C4BP. Also functions as a human immunodeficiency virus (HIV) receptor via binding the viral gp160 protein. Modulates hyphae formation
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MSSKIERIFSGPALKINTYLDKLPKIYNVFFIASISTIAGMMFGFDISSMSAFIGAEHYMRYFNSPGSDIQGFITSSMALGSFFGSIASSFVSEPFGRRLSLLTCAFFWMVGAAIQSSVQNRAQLIIGRIISGIGVGFGSAVAPVYGAELAPRKIRGLIGGMFQFFVTLGIMIMFYLSFGLGHINGVASFRIAWGLQIVPGLCLFLGCFFIPESPRWLAKQGQWEAAEEIVAKIQAHGDRENPDVLIEISEIKDQLLLEESSKQIGYATLFTKKYIQRTFTAIFAQIWQQLTGMNVMMYYIVYIFQMAGYSGNSNLVASSIQYVINTCVTVPALYFIDKVGRRPLLIGGATMMMAFQFGLAGILGQYSIPWPDSGNDSVNIRIPEDNKSASKGAIACCYLFVASFAFTWGVGIWVYCAEIWGDNRVAQRGNAISTSANWILNFAIAMYTPTGFKNISWKTYIIYGVFCFAMATHVYFGFPETKGKRLEEIGQMWEERVPAWRSRSWQPTVPIASDAELARKMEVEHEEDKLMNEDSNSESRENQA
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [25-498]
- IPR050360: Major Facilitator Superfamily Sugar Transporters (family) [27-523]
- IPR005828: Major facilitator, sugar transporter-like (family) [34-494]
- IPR020846: Major facilitator superfamily domain (domain) [32-483]
- IPR005829: Sugar transporter, conserved site (conserved_site) [89-350]
- IPR003663: Sugar/inositol transporter (family) [25-490]
Interaction partners: - Hgt2p
- Bifunctional protein GAL10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0051119 (sugar transmembrane transporter activity), GO:0015145 (monosaccharide transmembrane transporter activity), GO:0015149 (hexose transmembrane transporter activity), GO:0015578 (mannose transmembrane transporter activity), GO:0005355 (glucose transmembrane transporter activity), GO:0005353 (fructose transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0055085 (transmembrane transport), GO:0002683 (negative regulation of immune system process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0050777 (negative regulation of immune response), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:0050776 (regulation of immune response), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0006810 (transport), GO:0002698 (negative regulation of immune effector process), GO:0009268 (response to pH), GO:0034219 (carbohydrate transmembrane transport), GO:0030449 (regulation of complement activation), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0002921 (negative regulation of humoral immune response), GO:0036176 (response to neutral pH), GO:0034605 (cellular response to heat), GO:0015749 (monosaccharide transmembrane transport), GO:0071702 (organic substance transport), GO:0045916 (negative regulation of complement activation), GO:0002920 (regulation of humoral immune response), GO:0071467 (cellular response to pH), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0008643 (carbohydrate transport), GO:0036244 (cellular response to neutral pH), GO:0008645 (hexose transmembrane transport), GO:1904659 (glucose transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)