Protein: ATP-dependent RNA helicase DHX8 (A0A8M9Q925)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome
Subcellular location: Nucleus
Sequence: MAEIGEDELKKLEYLSLVSKVCTELDNHLGINDKDLAEFVISLAEKNTAFDGFKSALVKNGADFTDSLIGNLLRLIQTMRPPAKASTSKASFPAAKPKNEKDKLKELFPALCRPDNPTTRNMLDEDDVKVAADAMKELEMFMPSVSGTEPSSSKHRSETSSSSRKKRRSRSRSRDRDRDRDRDRERDRDRDRRRRHRSRSRSRSRSNERDRRKRRSRWHSRSRSRSPARTDRDKGSDRWKDKHVDRPPPEEPSVADIYNGKVTSIMQFGCFVQLEGLRKRWEGLVHISELRREGRVANVADVVSKGQRVKVKVLSFTGSKTSLSMKDVDQDTGEDLNPNRRRNVGGEGQEESAMRNPDRPTNLNLGHAPEVEDDTLERKRLTKISDPEKWEIKQMIAANVLSKEEFPDFDEETGILPKVDDEEDEDLEIELVEEEPPFLRGHTKQSMDMSPVKIVKNPDGSLSQAAMMQSALAKERREVKQAQREAEMDSIPMGLNKHWVDPLPDVDGRQIAANMRGIGMMPNDIPEWKKHAFGGNKASYGKKTQLSILEQRESLPIYKLKEQLIQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTTRGKIGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRTDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEVLYTKEPETDYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQPEGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKATVRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPTRLSKQKKQQRLEPLYNRYEEPNAWRISRAFRRR
InterPro domains: - IPR044762: DHX8/ Prp22, DEXH-box helicase domain (domain) [550-728]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [561-711]
- IPR001650: Helicase, C-terminal domain-like (domain) [746-926]
- IPR049588: DHX8, GH2-like domain (domain) [12-79]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [553-737]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [523-1169]
- IPR049621: DHX8 helicase, S1 domain (domain) [257-333]
- IPR003029: S1 domain (domain) [252-326]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [249-337]
- IPR048333: Helicase associated domain (HA2), winged-helix domain (domain) [947-975]
- IPR002464: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (conserved_site) [670-679]
- IPR007502: Helicase-associated domain (domain) [946-1036]
- IPR011709: DEAD-box helicase, OB fold (domain) [1093-1169]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0009790 (embryo development), GO:0007283 (spermatogenesis), GO:0048513 (animal organ development), GO:0048568 (embryonic organ development), GO:0048232 (male gamete generation), GO:0010467 (gene expression), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001892 (embryonic placenta development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)