Protein: Neuroendocrine protein 7B2 (Secretogranin V) (Secretogranin-5) (Secretory granule endocrine protein I) [Cleaved into: N-terminal peptide; C-terminal peptide] (P01165)
Organism: Sus scrofa (Pig)
Function: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Subcellular location: Secreted {ECO:0000269|PubMed:6514132}. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000269|PubMed:6514132}.
Sequence: MVSTMLSGLVLWLTFGWTPALAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNTPKDFSEDQGYPDPPNPCPIGKTDDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE
InterPro domains: - IPR007945: Neuroendocrine 7B2 precursor (family) [5-206]
Interaction partners: - Rho GTPase activating protein 11A.
- Neuroendocrine convertase 2
- Proprotein convertase subtilisin/kexin type 7.
- Secretogranin-2
- Secretogranin-1
- Proprotein convertase subtilisin/kexin type 4
- Membrane-bound transcription factor site-1 protease
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0023056 (positive regulation of signaling), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:1901564 (organonitrogen compound metabolic process), GO:0046887 (positive regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:0060341 (regulation of cellular localization), GO:0006082 (organic acid metabolic process), GO:0019538 (protein metabolic process), GO:0010647 (positive regulation of cell communication), GO:0043603 (amide metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0046883 (regulation of hormone secretion), GO:1903532 (positive regulation of secretion by cell), GO:0036211 (protein modification process), GO:0006631 (fatty acid metabolic process), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0043436 (oxoacid metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:0050714 (positive regulation of protein secretion), GO:0019752 (carboxylic acid metabolic process), GO:0032024 (positive regulation of insulin secretion), GO:0002791 (regulation of peptide secretion), GO:0050796 (regulation of insulin secretion), GO:0043066 (negative regulation of apoptotic process), GO:0006468 (protein phosphorylation), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)