Protein: Leptin receptor overlapping transcript-like 1 (Endospanin-2) (Q6PDU4)
Organism: Rattus norvegicus (Rat)
Function: Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGVVVSAFGLPVVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW
InterPro domains: - IPR007262: Vps55/LEPROT (family) [1-131]
Interaction partners: - Tmem50a protein
- Transmembrane protein 50B, isoform CRA_b.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0032388 (positive regulation of intracellular transport), GO:0010646 (regulation of cell communication), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0009966 (regulation of signal transduction), GO:0051222 (positive regulation of protein transport), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:1904893 (negative regulation of receptor signaling pathway via STAT), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0032880 (regulation of protein localization), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0032386 (regulation of intracellular transport), GO:1903955 (positive regulation of protein targeting to mitochondrion), GO:1903747 (regulation of establishment of protein localization to mitochondrion), GO:0046425 (regulation of receptor signaling pathway via JAK-STAT), GO:2000008 (regulation of protein localization to cell surface), GO:0033157 (regulation of intracellular protein transport), GO:1903749 (positive regulation of establishment of protein localization to mitochondrion), GO:0046426 (negative regulation of receptor signaling pathway via JAK-STAT), GO:1903214 (regulation of protein targeting to mitochondrion), GO:1903533 (regulation of protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)