Protein: Guanine nucleotide-binding protein subunit alpha homolog (Protein concertina) (P25157)
Organism: Drosophila melanogaster (Fruit fly)
Function: May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:1899050}.
Sequence: MSGITLTKLTQERISIPNNNVITNGVENNIDSDTLSGTLTHLMEEHRTRVGAVTGPEAATTSTDGLISNGAERLRLQGSRLQTSRFACFRCCGNIITYLVRLRSTPEELEQRYKSKEIDKFLEKEKHTFRRQVKLLLLGAGESGKSTFLKQMRIIHGVNFDYELLLEYQSVIYQNVIRGMQVLLDAREKLNIAWGSDGREQDAYDAKLMECNSLDVPKFMEYAPPISRLWQDRGIRRAFERRREFQISDSVSYFLDEIQRLATPDYVPTHKDILHCRKATKGVYEFCVKVQNIPFVFVDVGGQRTQRQKWTRCFDSSVTSIIFLVSSSEFDQVLAEDRKTNRLEESKNIFDTIVNNATFKGISIILFLNKTDLLEQKVCNPETDIRWYYPHFNGNPHSVLDVQNFILQMFMSVRRSSSISRIYHHFTTAIDTRNINVVFNSVKDTILQRNLNALMLQ
InterPro domains: - IPR011025: G protein alpha subunit, helical insertion (homologous_superfamily) [160-280]
- IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit (family) [111-457]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [131-451]
- IPR000469: G-protein alpha subunit, group 12/13 (family) [158-457]
Interaction partners: - Rho guanine nucleotide exchange factor 2, isoform D
- Guanine nucleotide-binding protein subunit beta-1
- Ras-like GTP-binding protein Rho1
- G protein beta subunit 5
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit gamma-e
- Chaperone Ric-8
- Guanine nucleotide-binding protein subunit gamma-1
- Guanine nucleotide-binding protein subunit gamma
- G protein alpha s subunit subunit alpha)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:2000026 (regulation of multicellular organismal development), GO:0001558 (regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0044089 (positive regulation of cellular component biogenesis), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0044087 (regulation of cellular component biogenesis), GO:1901890 (positive regulation of cell junction assembly), GO:0032535 (regulation of cellular component size), GO:0050770 (regulation of axonogenesis), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0051965 (positive regulation of synapse assembly), GO:1901888 (regulation of cell junction assembly), GO:0045887 (positive regulation of synaptic assembly at neuromuscular junction), GO:0008582 (regulation of synaptic assembly at neuromuscular junction), GO:0051960 (regulation of nervous system development), GO:0034330 (cell junction organization), GO:1904398 (positive regulation of neuromuscular junction development), GO:0051963 (regulation of synapse assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050808 (synapse organization), GO:1904396 (regulation of neuromuscular junction development), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0019898 (extrinsic component of membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0019897 (extrinsic component of plasma membrane), GO:1905360 (GTPase complex), GO:0098562 (cytoplasmic side of membrane), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0005834 (heterotrimeric G-protein complex), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)