Protein: Glycerol-3-phosphate dehydrogenase [NAD(+)] 1 (EC 1.1.1.8) (Q00055)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the production and accumulation of glycerol during hyperosmotic stress conditions. Glycerol acts as a osmoregulator that prevents loss of water and turgor of the cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15210723}. Peroxisome {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15210723}.
Sequence: MSAAADRLNLTSGHLNAGRKRSSSSVSLKAAEKPFKVTVIGSGNWGTTIAKVVAENCKGYPEVFAPIVQMWVFEEEINGEKLTEIINTRHQNVKYLPGITLPDNLVANPDLIDSVKDVDIIVFNIPHQFLPRICSQLKGHVDSHVRAISCLKGFEVGAKGVQLLSSYITEELGIQCGALSGANIATEVAQEHWSETTVAYHIPKDFRGEGKDVDHKVLKALFHRPYFHVSVIEDVAGISICGALKNVVALGCGFVEGLGWGNNASAAIQRVGLGEIIRFGQMFFPESREETYYQESAGVADLITTCAGGRNVKVARLMATSGKDAWECEKELLNGQSAQGLITCKEVHEWLETCGSVEDFPLFEAVYQIVYNNYPMKNLPDMIEELDLHED
InterPro domains: - IPR008927: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily (homologous_superfamily) [233-391]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [34-234]
- IPR006109: Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal (domain) [234-379]
- IPR013328: 6-phosphogluconate dehydrogenase, domain 2 (homologous_superfamily) [234-391]
- IPR011128: Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal (domain) [36-201]
- IPR017751: Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic (family) [36-382]
- IPR006168: Glycerol-3-phosphate dehydrogenase, NAD-dependent (family) [29-391]
Interaction partners: - Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Glycerol-3-phosphate O-acyltransferase 2
- Glycerol-3-phosphate O-acyltransferase 1
- Dihydroxyacetone kinase 1
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- Nicotinamidase
- Dihydroxyacetone kinase 2
- Lipid phosphate phosphatase 1
- Diacylglycerol pyrophosphate phosphatase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0003676 (nucleic acid binding), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0019400 (alditol metabolic process), GO:0019751 (polyol metabolic process), GO:0052646 (alditol phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0016052 (carbohydrate catabolic process), GO:0006071 (glycerol metabolic process), GO:0046174 (polyol catabolic process), GO:0006113 (fermentation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)