wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Chemokine-like protein TAFA-1 (Q7TPG8)
Organism: Mus musculus (Mouse)
Function: Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation.
Subcellular location: Secreted {ECO:0000269|PubMed:29799787}.
Sequence: MAMVSAMSWALYLWISACAMLLCHGSLQHTFQQHHLHRPEGGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGKVAGTTRNRPSCVDASIVIGKWWCEMEPCLEGEECKTLPDNSGWMCATGNKIKTTRIHPRT
InterPro domains: - IPR051743: TAFA chemokine-like (family) [7-129]
- IPR020350: Chemokine-like protein TAFA (family) [41-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0065008 (regulation of biological quality), GO:0048870 (cell motility), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0097529 (myeloid leukocyte migration), GO:0010469 (regulation of signaling receptor activity), GO:0072593 (reactive oxygen species metabolic process), GO:0010646 (regulation of cell communication), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0060326 (cell chemotaxis), GO:0006801 (superoxide metabolic process), GO:0031644 (regulation of nervous system process), GO:1905517 (macrophage migration), GO:0016192 (vesicle-mediated transport), GO:0048246 (macrophage chemotaxis), GO:0051931 (regulation of sensory perception), GO:0006909 (phagocytosis), GO:0051930 (regulation of sensory perception of pain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase) (P9WGV1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00086}.
Sequence: MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTTGQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLKRAI
InterPro domains: - IPR002133: S-adenosylmethionine synthetase (family) [1-403]
- IPR022631: S-adenosylmethionine synthetase, conserved site (conserved_site) [131-287]
- IPR022636: S-adenosylmethionine synthetase superfamily (homologous_superfamily) [6-401]
- IPR022628: S-adenosylmethionine synthetase, N-terminal (domain) [7-106]
- IPR022630: S-adenosylmethionine synthetase, C-terminal (domain) [253-392]
- IPR022629: S-adenosylmethionine synthetase, central domain (domain) [130-251]
Interaction partners: - 6,7-dimethyl-8-ribityllumazine synthase
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- Methionine synthase
- Large-conductance mechanosensitive channel
- S-methylmethionine:homocysteine methyltransferase
- Adenosylhomocysteinase
- Guanylate kinase
- Ribulose-phosphate 3-epimerase
- GMP synthase
- Phosphoglycerate kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0046500 (S-adenosylmethionine metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044272 (sulfur compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Spn43Ac (Q6V6U7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: FSSELFKEIIKSQSQQNVVFSPFSVHALLALIYGASDGKTFRELQKAGEFSKNAMAVAQDFESVIKYKKHLEGADLTLATKVYYNRELGGVNHSYDEYAKFYFSAGTEAVDMQNAKDTAAKINAWVMDTTRNKIRDLVTPTDVDPQTQALLVNAVYFQGRWEHEFATMDTSPYDFQHTNGRISKVAMMFNDDVYGLAELPELGATALELAYKDSATSMLILLPNETTGLGKMLQQLSRPEFDLNRVAHRLRRQSVAVRLPKFQFEFEQDMTEPLKNLGVHQMFTPNSQVTKLMDQPVRVSKILQKAYINVGEAGTEASAASYAKFVPLSLPPKPTEFVANRPFVFAVRTPASVLL
InterPro domains: - IPR042178: Serpin superfamily, domain 1 (homologous_superfamily) [5-307]
- IPR000215: Serpin family (family) [1-348]
- IPR036186: Serpin superfamily (homologous_superfamily) [1-350]
- IPR042185: Serpin superfamily, domain 2 (homologous_superfamily) [157-352]
- IPR023796: Serpin domain (domain) [1-355]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009620 (response to fungus), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Protein BIIDXI (Q8LAR0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:29238286, ECO:0000269|PubMed:30253266}. Note=Accumulates at the cell wall upon root-knot nematode Meloidogyne incognita infection (PubMed:29238286). Observed in epidermal cells of both hypocotyls and primary roots (PubMed:30253266). {ECO:0000269|PubMed:29238286, ECO:0000269|PubMed:30253266}.
Sequence: MKEMGVIVLLLLHSFFYVAFCFNDGLLPNGDFELGPRHSDMKGTQVINITAIPNWELSGFVEYIPSGHKQGDMILVVPKGAFAVRLGNEASIKQKISVKKGSYYSITFSAARTCAQDERLNVSVAPHHAVMPIQTVYSSSGWDLYSWAFKAQSDYADIVIHNPGVEEDPACGPLIDGVAMRALFPPRPTNKNILKNGGFEEGPWVLPNISSGVLIPPNSIDDHSPLPGWMVESLKAVKYIDSDHFSVPQGRRAVELVAGKESAVAQVVRTIPGKTYVLSFSVGDASNACAGSMIVEAFAGKDTIKVPYESKGKGGFKRSSLRFVAVSSRTRVMFYSTFYAMRNDDFSSLCGPVIDDVKLLSARRP
InterPro domains: - IPR052437: Pectin Methylation Modulator (family) [8-362]
- IPR006946: DUF642 L-galactono-1,4-lactone-responsive gene 2-like domain (domain) [25-359]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [22-181]
Interaction partners: - Proline-tRNA ligase
- Protein RALF-like 22
- Helicase and polymerase-containing protein TEBICHI
- Putative beta-glucosidase 41
- Signal peptide peptidase
- At4g12520
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:1905392 (plant organ morphogenesis), GO:0099402 (plant organ development), GO:0048731 (system development), GO:0048364 (root development), GO:0010015 (root morphogenesis), GO:0022622 (root system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: N-sulfoglucosamine sulfohydrolase (sulfamidase) (B1ATE0)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MHCPGLACCTILLVLGLCGAHSRNVLLIVADDGGFESGVYNNTAIATPHLDALSRHSLIFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVQSLPLLLNQAGVRTGIIGKKHVGPETVYPFDFAFTEENSSVMQVGRNITRIKQLVQKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGYIPDWTPQIYDPQDVMVPYFVPDTPAARADLAAQYTTIGRMDQERQDQPVLARYSRAFAGVISRAPTALGPGQRRLREPSRPHPYHPGLVLHPVPQLCHLWLKDDPAHRPIPPAGAGGRAPLGHCLQQPEPPRGHHVLPDALGVPPELPPHSQPELQDAISHRPRFLCLADLPGPPEPNHHRPAHGLVQGPPPLLLPGTLGTLRHQPGPSRDTEPGR
InterPro domains: - IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [22-251]
- IPR024607: Sulfatase, conserved site (conserved_site) [68-125]
- IPR000917: Sulfatase, N-terminal (domain) [23-248]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0009057 (macromolecule catabolic process), GO:0044273 (sulfur compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009100 (glycoprotein metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0006029 (proteoglycan metabolic process), GO:0006516 (glycoprotein catabolic process), GO:0030167 (proteoglycan catabolic process), GO:0030201 (heparan sulfate proteoglycan metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0005764 (lysosome), GO:0043202 (lysosomal lumen)
Protein: Potassium channel subfamily K member 6 (G3V8R8)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Late endosome membrane {ECO:0000269|PubMed:28381826}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:28381826}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MRRGALLASALVAYAGYLALGALLVARLERPHEARLRAELGTLREQLLRHSPCVAAHALDAFVERVLAAGRLGRAVLANASGPANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLLTHAPLSWLSLRWGWHPQRAARWHLVALLMVIVAIFFLIPAAVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRSLYKVLVTAYLFLGLVAMVLVLQTFRRVSDLHGLTELILLPDPDPARLHQDEDDQVDILDARTDLHQHLSAASHANYASIPR
InterPro domains: - IPR013099: Potassium channel domain (domain) [90-258]
- IPR005408: Two pore domain potassium channel, TWIK family (family) [53-272]
- IPR003280: Two pore domain potassium channel (family) [5-256]
- IPR005409: Two pore domain potassium channel, TWIK-2 (family) [153-295]
- IPR003092: Two pore domain potassium channel, TASK family (family) [1-313]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity), GO:0005242 (inward rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Large ribosomal subunit protein eL34A (60S ribosomal protein L34-A) (O42846)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Sequence: MAQRVTYRRRLAYNTRSNRTRIIKTPGNNIRYLHIKKLGTIPRCGDTGVPLQGIPALRPREFARLSHNKKTVQRAYGGCLSANAVKDRIVRAFLIEEQKIVKQKLKQLSSQK
InterPro domains: - IPR008195: Large ribosomal subunit protein eL34 (family) [1-111]
- IPR038562: Large ribosomal subunit protein eL34, C-terminal domain superfamily (homologous_superfamily) [40-107]
- IPR018065: Large ribosomal subunit protein eL34, conserved site (conserved_site) [15-28]
Interaction partners: - Large ribosomal subunit protein eL39
- Large ribosomal subunit protein eL31
- Large ribosomal subunit protein uL29
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL29
- Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein eL22
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Nodulin-like domain-containing protein (Q381C3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MACSLRQCLLSYGVAESAMLREQVEEDVTTPVSEHEEEEEAAPTTHLLSPRGTVRLIDGYESTGHRDTHCLSPDSRERGSWIYHRPPIYGLQALSEPKRFWQLVVGALCCFVVSSSFTFNLYSGQLQAKFNFTQNDITSIFTGSDVAGILMLPLGAVYDKYGARPVFILALLTQPVGAILQALTYDDFIKGNLYLFIFYSALQAVGTWLLDTAAVMTLLSIFPSDKGPVVALSKVITGIGYGVIGAIHSAFFYGGEAKDTRNFFIFLASIGVVATVLGYMYLEDPPYVVKGSEVDTITRKERVTRRRLRRIYLRQRPSGLRFAIGFGIVAVLMVYLPVQAIVSMYFNLGHRYRVSFACTTVAILALYPVMALPLQCLERSQSLILPMTSTRCSERSSCVSRAASESVGSVACVDDLDYMAPQFHIKLADNIKTLRFWALMWTMFSLSGAEVLVLANMRFLLAAFDGGLLADTYVGYLLVLTSVGSGFGRIILSLFEMVSQNRSAEERIPITAALFVPAVVQVVALSLFFVLPAPLLAIPCFLVSFAGGCSAAASVIVVRTIFASDVGKYYNCITVATVVSSLLINRGLYGEVYTHEAMKEGKTICLGRQCVILPIIVVLVACVSSLLAVGYIHRDYSQHCEHMFELHKQRHASNEAPVKADHIGFNFKRSGKQSPAGGSAANI
InterPro domains: - IPR011701: Major facilitator superfamily (family) [105-365]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [95-595]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Glutathione S-transferase U1 (AtGSTU1) (EC 2.5.1.18) (GST class-tau member 1) (Glutathione S-transferase 19) (Q9ZW30)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Subcellular location: Cytoplasm, cytosol {ECO:0000305}.
Sequence: MAEKEESVKLLGFWASPFSRRVEMALKLKGVPYEYLEEDLPNKTPLLLELNPLHKKVPVLVHNDKILLESHLILEYIDQTWKNSPILPQDPYEKAMARFWAKFIDDQILTLGFRSLVKAEKGREVAIEETRELLMFLEKEVTGKDFFGGKTIGFLDMIAGSMIPFCLARLWKGIGIDMIPEEKFPELNRWIKNLEEVEAVRGCIPPREKQIERMTKIAETIKSA
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [7-108]
- IPR045074: Glutathione S-transferases Tau, C-terminal alpha-helical domain, plant (domain) [91-217]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [79-220]
- IPR045073: Glutathione S-transferase Omega/Tau-like (family) [4-223]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [106-196]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [90-217]
- IPR040079: Glutathione transferase family (family) [4-223]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [6-85]
Interaction partners: - Glutathione S-transferase DHAR2
- Glutathione S-transferase U25
- Glutathione S-transferase DHAR3, chloroplastic
- Glutathione S-transferase DHAR1, mitochondrial
- Glutathione S-transferase F2
- Glutathione S-transferase U7
- Probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial
- Glutathione S-transferase U26
- Glutathione S-transferase F7
- Glutathione synthetase, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004364 (glutathione transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009407 (toxin catabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0042221 (response to chemical), GO:0044248 (cellular catabolic process), GO:0009404 (toxin metabolic process), GO:0009636 (response to toxic substance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)