Protein: Small ribosomal subunit protein eS4 (P62702)
Organism: Mus musculus (Mouse)
Function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Sequence: MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG
InterPro domains: - IPR038237: Small ribosomal subunit protein eS4, central domain superfamily (homologous_superfamily) [122-172]
- IPR032277: Small ribosomal subunit protein eS4, C-terminal domain (domain) [212-259]
- IPR000876: Small ribosomal subunit protein eS4 (family) [1-255]
- IPR041982: Small ribosomal subunit protein eS4, KOW domain (domain) [175-229]
- IPR018199: Small ribosomal subunit protein eS4, N-terminal, conserved site (conserved_site) [8-22]
- IPR005824: KOW (domain) [178-211]
- IPR014722: Large ribosomal subunit protein uL2, domain 2 (homologous_superfamily) [175-245]
- IPR036986: RNA-binding S4 domain superfamily (homologous_superfamily) [1-117]
- IPR013845: Small ribosomal subunit protein eS4, central region (domain) [95-169]
- IPR013843: Small ribosomal subunit protein eS4, N-terminal (domain) [3-39]
- IPR002942: RNA-binding S4 domain (domain) [42-106]
Interaction partners: - Small ribosomal subunit protein uS15
- Small ribosomal subunit protein uS10
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein uS7
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL24
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS10
- Small ribosomal subunit protein eS10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0071310 (cellular response to organic substance), GO:0034097 (response to cytokine), GO:0070670 (response to interleukin-4), GO:0071345 (cellular response to cytokine stimulus), GO:0071353 (cellular response to interleukin-4)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0045202 (synapse)