Protein: Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.4.19.12) (Deubiquitinating enzyme 30) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Ub-specific protease 30) (A2BGT0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Deubiquitinating enzyme that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q70CQ3}.
Sequence: MPWCKQGTTDKLVREFLRTGAAARNKMMKNWGVIGGIAAAMAAGVYVLWGPISDRRKKRKGMVPGLLNLGNTCFMNSLLQGLAACPSFIRWLEDFTSQNSADRERTERETQLSRSLMQLLKALSSHDPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELFHVLTSSLEEEQERQPRVAHLFDMQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRHPFHGRLTSYMACKRCEQQSPVHYDSFDSLSLSIPSIQWGRPVTLDQCLQHFISSETIKEVECENCTKQQAGELVNGEVLESQRTTFVKQLKLGKRLTWSKEGSPIKRQEHVQFTEYLSLDRYKHCSAAQSQQKTSRTNKAKASADPKDKAIANGVDSEHCNNNKPQSNGTFPSVFLHSPGLSSQLNLTYDYSTSEYLFRLTAVLVHHGDMHSGHFITYRRCPAAPRGTSPFSSQWLWVSDDSVRKASLQEVLSSSAYLLFYERMQRPGLRVEE
InterPro domains: - IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [55-483]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [65-433]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [65-479]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [61-481]
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [64-482]
Interaction partners: - Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-C
- Polyubiquitin-B
- Si:ch211-202a12.4.
- Ubiquitin-ribosomal protein eL40 fusion protein
- DUSP domain-containing protein.
- Transcription and mRNA export factor ENY2
- Peroxisomal biogenesis factor 5.
- Ubiquitin-specific peptidase 19.
- Ubiquitin-specific peptidase 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis), GO:0006996 (organelle organization), GO:0070646 (protein modification by small protein removal), GO:0007005 (mitochondrion organization), GO:0070647 (protein modification by small protein conjugation or removal), GO:0048284 (organelle fusion), GO:0016579 (protein deubiquitination), GO:0008053 (mitochondrial fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)