Protein: Integrin subunit alpha 6 (A0A8I6AJE9)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Sequence: MAVAGQLCLLYLSAGLLARLSTAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQKANRTGGLYSCDITSRGPCTRIVFDNDADPMSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETDHDESLVPVPANSYLGLLFLTSLSYTDPDQFVYKTRPPRERPDTSPDVMMNSYLGFSLDSGKGIVSKDDITFVSGAPRANHSGAVVLLKRDMKSAHLLLEYIFDGEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGRWSNVKPVRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLEGTTPFFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINILKTITVTPSRIDLRQKSMCGSPSGICLKVKACFEYTAKPSGYNPPISILGILEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKEGCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNGPSDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLKNLGTATLNIQWPKEISNGKWLLYLMKVESKGLEQVVCEPHNEINFLKLKESHNSRKKRELPEKQIDDSRKFSLFSERKYQTLNCSVNVRCVNIRCPLRGLDSKASLVLRSRLWNSTFLEEYSKLNYLDILVRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVAQYSGIAWWIILLAVLAGILMLALLVFLLWKCGFFKRSRYDDSVPRYHAVRIRKEEREINDEKHTDNPEKKWPPKWNENESYS
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [665-830]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1076-1083]
- IPR000413: Integrin alpha chain (family) [294-1083]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [503-663]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [24-506]
- IPR013517: FG-GAP repeat (repeat) [355-449]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [505-1057]
- IPR013519: Integrin alpha beta-propellor (repeat) [30-522]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [836-1042]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0050840 (extracellular matrix binding), GO:0005515 (protein binding), GO:0043236 (laminin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0030155 (regulation of cell adhesion), GO:0045785 (positive regulation of cell adhesion), GO:0098609 (cell-cell adhesion), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0014070 (response to organic cyclic compound), GO:0010810 (regulation of cell-substrate adhesion), GO:0071310 (cellular response to organic substance), GO:0071407 (cellular response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0098636 (protein complex involved in cell adhesion), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0098802 (plasma membrane signaling receptor complex), GO:0070161 (anchoring junction), GO:0008305 (integrin complex), GO:0098858 (actin-based cell projection), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction), GO:0030175 (filopodium)