Protein: Regulator of G-protein signaling 8 (RGS8) (P49804)
Organism: Rattus norvegicus (Rat)
Function: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12880183}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane {ECO:0000269|PubMed:9394004}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:12880183}. Cell projection, dendrite {ECO:0000269|PubMed:12880183}. Nucleus {ECO:0000269|PubMed:12880183}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000269|PubMed:12880183}.
Sequence: MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVTKAHRIFEEFVDVQAPREVNIDFQTREATRKNMQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
InterPro domains: - IPR044926: RGS, subdomain 2 (homologous_superfamily) [83-152]
- IPR016137: RGS domain (domain) [53-172]
- IPR034949: Regulator of G-protein signalling 8, RGS domain (domain) [46-170]
- IPR024066: RGS, subdomain 1/3 (homologous_superfamily) [45-169]
- IPR036305: RGS domain superfamily (homologous_superfamily) [42-174]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-5
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Regulator of G-protein signaling 7-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0019900 (kinase binding), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009966 (regulation of signal transduction), GO:0097305 (response to alcohol), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0045471 (response to ethanol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)