Protein: AP-4 complex subunit epsilon (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon) (Epsilon subunit of AP-4) (Epsilon-adaptin) (Q8L7A9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Associated with the trans-Golgi network. {ECO:0000250}.
Sequence: MEQLKTIGRELAMGSQGGFGQSKEFLDLVKSIGEARSKAEEDRIVLSEVDILKRRLLEPDIPKRKMKEYIIRLVYIEMLGHDASFGYIYAVKMTHDDNLLLKRTGYLAVTLFLNEDHDLIILIVNTIQKDLRSDNYLVVCAALNAICRLINEETIPAVLPQVVELLNHQKEAVRKKAIMALHRFHRKSPSSVSHLVSNFRKRLCDNDPGVMGATLCPLFDLISEDVNSYKDLVSSFVSILKQVTERRLPKSYDYHQMPAPFIQIKLLKIMALLGSGDKNASDIMSMVLGDLFRKCDSSTNIGNAILYECIRCISCILPNPKLLEAAADAISKFLKSDSHNLKYMGIDGLGRLIKISPDIAEQHQLAVIDCLEDPDDTLKRKTFELLYKMTKSSNVEVIVDRMIDYMISINDNHYKTEIASRCVELAEQFAPSNQWFIQIMNKVFEHAGDLVNIKVAHNLMRLIAEGFGEDDDDADSKLRLSAVESYLQLISEPKLPSLFLQVISWVLGEYGTADGKYSASYISGKLCDVADAYSSDETVKGYAVSALMKIYAFEIASGRKVDVLPECQSLIEELLASHSTDLQQRAYELQALLALDARAVETILPLDASCEDIEVDKDLSFLNGYIQQAIESGAQPYISERERSGMFETTDYHPQDHHEVPTHALRFEAYELPKPSVPPQASNELVPVPEPSYYSESHQPISTSLVSERESSEIKLRLDGVKQKWGRPSYQSTTAASSTTPQAANGISTHSDAGVGSSSSKPRSSYEPKKPEIDPEKQRLAASLFGGSSSRTDKRSSSGGHKPAKGTANKTATVPKENQTPVQPPPDLLDFGEPTATTATAMDPFKELEGLMDSSSQDGGSSDVMGLYSDAAPVTTTTSVDSLLSELSDSSKGNSRTYQPQTSKGPNTKEALEKDALVRQMGVNPTSQNPTLFKDLLG
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [22-597]
- IPR017109: Adaptor protein complex AP-4, epsilon subunit (family) [11-938]
- IPR050840: Adaptor Complexes Large Subunit (family) [27-815]
- IPR011989: Armadillo-like helical (homologous_superfamily) [12-606]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [59-594]
Interaction partners: - Beta-adaptin-like protein C
- AP-1 complex subunit mu-2
- Beta-adaptin-like protein A
- Beta-adaptin-like protein B
- AP-4 complex subunit mu
- Clathrin heavy chain 2
- AP-4 complex subunit sigma
- AP-2 complex subunit mu
- AP3-complex subunit beta-A
- Clathrin heavy chain 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0016192 (vesicle-mediated transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0048193 (Golgi vesicle transport), GO:0033365 (protein localization to organelle), GO:0006623 (protein targeting to vacuole), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0006896 (Golgi to vacuole transport), GO:0006892 (post-Golgi vesicle-mediated transport), GO:0072665 (protein localization to vacuole)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005905 (clathrin-coated pit), GO:0005794 (Golgi apparatus), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098791 (Golgi apparatus subcompartment), GO:0030135 (coated vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005802 (trans-Golgi network), GO:0030136 (clathrin-coated vesicle), GO:0097708 (intracellular vesicle)