Protein: Chromosome-associated kinesin KIF4 (Chromokinesin) (P33174)
Organism: Mus musculus (Mouse)
Function: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (By similarity). Required for mitotic chromosomal positioning and bipolar spindle stabilization.
Subcellular location: Nucleus {ECO:0000269|PubMed:7929562}. Chromosome {ECO:0000269|PubMed:7929562}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:7929562}.
Sequence: MKEEVKGIPVRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGNDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEINKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAAELNHLKQQVQQLQILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAACMTATIDTAGEADTQVQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHLNGLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFSYDEIHGQDSGAEDSIAKQIESLETELELRSAQIADLQQKLLDAESEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVSKLESSLNQSKASCIDVQKMLFEEQNHFAKIETELKEELVKVEQQHQEKVLYLLSQLQQSQMTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQQLLQENSAIKQKLTLLQVASKQKPHLTRNIFQSPDSSFEYIPPKPKPCRIKEKCLEQSFAVEGLQYYSEPSVAEQDNEDSDDHADEEWIPTKLVKVSKKSIQGCSCKGWCGNKQCGCRKQKSDCNVSCSCDPTKCRNRHQNQDNSDAIELNQDSENSFKLEDPTEVTSGLSFFHPICATPSSKILKEMCDADQVQLKQPVFVSSSDHPELKSIASESQENKAIGKKKKRALASNTSFFSGCSPIQEESH
InterPro domains: - IPR033467: Tesmin/TSO1-like CXC domain (domain) [1081-1123]
- IPR027640: Kinesin-like protein (family) [6-1123]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [235-246]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [10-369]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [2-349]
- IPR001752: Kinesin motor domain (domain) [7-345]
Interaction partners: - Protein regulator of cytokinesis 1
- Kinesin-like protein KIF20A
- Kinesin-like protein KIF11
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Kinesin-like protein KIF22
- Abnormal spindle-like microcephaly-associated protein homolog
- Kinesin-like protein KIF23
- Maternal embryonic leucine zipper kinase
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Disks large-associated protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0007059 (chromosome segregation), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0007051 (spindle organization), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0051225 (spindle assembly), GO:0098813 (nuclear chromosome segregation), GO:0140014 (mitotic nuclear division), GO:0007052 (mitotic spindle organization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0000819 (sister chromatid segregation), GO:0048285 (organelle fission), GO:0090307 (mitotic spindle assembly), GO:0051276 (chromosome organization), GO:0000280 (nuclear division), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0097542 (ciliary tip), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)