Protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X4 (A0A0R4IM47)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Golgi apparatus. Membrane
Sequence: MRSSSSRLSSFSSRDSLWSRMPDQISVSEFLSETTEDYNSPTTSSFTTRLQSCRNTVNVLEEALDQDRTALQKVKKSVKAIYNSGQEHVQNEENYGQALDKFGSNFISRDNSDLGTAFIKFSGLIKELAALLKNLLQSLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRIFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSKQSGYSMHQLQGNKEFGSEKKGYLFKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPVRLNLLTCQVKPSGEDKKCFDLISHNRTYHFQAEDEQEFVIWISVLTNSKEEALNMAFRGEQSAGDDSLEDLTKAIIEDVLRIPGNEVCCDCGAPEPKWLSTNLGILTCIECSGIHREMGVHISRIQSMELDKLGTSELLLAKNVGNSSFNEILEGNLPSPSPKPAPSSDMTERKEYINAKYVEHRFARRTATTATARQGDLYEAVRTRDLMALIQLYADGVELMDPFPEAGQDPGETALHFAVRTSDQTSLHLVDFLVQNSGTLDRQTESGNAALHYCCTYEKPECLKLLLRGKPSIDLVNQNGETALDIARRLRNVQCEELLVEAAAGRFNPHVHVEYEWNLRLEEIDESDDDLDDKPSPVKKERSPRPQSFCHSSSVSPQEKLTLPGYLGHRDKQRLSYGAFANPVYSTSTETPASPVSEGPTIASKTPAKGSESTPPSANRTSPANKFEGIQQQQSTTSMNTKATFGPRVLPKLPQKVALRKIDTIHLPSVDKSGPDVLQKPPQAQDAPPTRASDTITRPTEPPPKIPQVAERSQPVDVPQKPHISDLPPKPQLSDLPPKPQLSDLPPKPQLSDLPPKPQLKDLPPKPQISDLPSKPAVCSASEATQRQSTQEETSPKPQLTETQSFSQQEELSPRQASEDTNGAPAGALEMPVPMPRKINTVAKNKAKRVKTIYDCQADNDDELTFVEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPMSFVHILSD
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [1037-1096]
- IPR038016: ASAP1, SH3 domain (domain) [1039-1095]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [319-432]
- IPR037928: ASAP1, BAR domain (domain) [54-268]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [438-555]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [433-564]
- IPR001849: Pleckstrin homology domain (domain) [324-418]
- IPR001452: SH3 domain (domain) [1035-1097]
- IPR002110: Ankyrin repeat (repeat) [600-701]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [561-709]
- IPR043593: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein (family) [21-1097]
- IPR037844: ASAP, PH domain (domain) [316-422]
- IPR001164: Arf GTPase activating protein (domain) [439-560]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [32-347]
- IPR004148: BAR domain (domain) [54-286]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0003824 (catalytic activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0005096 (GTPase activator activity), GO:0030695 (GTPase regulator activity), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0010842 (retina layer formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003407 (neural retina development), GO:0016043 (cellular component organization), GO:0060041 (retina development in camera-type eye), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0060219 (camera-type eye photoreceptor cell differentiation), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction)