Protein: Nucleolar complex protein 1 (Q9VTE6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in rRNA processing and ribosome maturation. May also act as a transcription factor (Probable)
Subcellular location: Nucleus, nucleolus
Sequence: MPAAVATGVQFGGPPKNKKIVFDDSGEAVVKQNKKEHPQRPKFEGKEQVKKPQKIKFGEDGKAKGAKSFNKNHQKPDFANKPQRIKFGDDGEQVASKSFNQNHKNGPKPQKIKFGEDREAVHQKPFNKNNHKHNGQKSDFANKPQKIKFTDDGEDEVTANSSNTKTEPTKKSQKIKFGDDGESKENFKKPQRIKFDEDGAGKNVSDSDGDSDEELGDSISKKHNKYQSKIDEDEESQKKWYHVHPDYPSTDEVLDMKENDQLELYNLCKNSFEAEKITFNKRNPSDARWLQTALHKGTAKDRANAGALLVTSNPLGNLEALSTLIGFCKISNKASNDVIAVLTDLWQEVLLPPNRKLLAVHTRGADWKKLKKDENLRNEQKRRIYAYWHFESELKDQYHEFLKNVMQGLQTGQEHNKNSSIVSAARLLAYAPEKEQLLLTMLVNKLGDPIAKIASKALHHLSEVAQKHPNMCGVIVAEAEKLLFRNNISERAQHFALCFLSSIAPSGRPEVCTKLVNICFALFKVLVQKGAVNNRTMQAILRCLQKAIVEAKPAKDSNGELLTKEMQDTIYRLVHLADIRVAVQTLGLLLQLVAVKTEKSDRFYNALYVKLLDLNLINVGSKTAAHLLHIVHRAIHIDNHVARAQAFVKRLLQLTLYAPPHIAAGCLIVIHKLLRMRRELIGGTGASEEVEEGSKVVLPISADLDKFGSDDEEVYEDVKDEADDTKDSNPLEEKADNDVKSSASSWHHARVAATEAKVRDIDSCKYDPYHRVPAFAGAAYALRHELLLLRQHYHPTVQVFAEQILQQSRIDYYGDPLRDFGLPHFLERFAFKNPKKLEASQAAENATVAHKRYMAHGARGRPVKSLTKANCTEDEMFIFNFLEHKRRQAEIVAQNKKQKEIKKDAAEEGDDGEAGEEYLKEGEVDDDEFEAYLDGYFGKKFKEGVDEEQDEEELNFLQELGGEIKKDKSKDKKKKKQSDKAEDEMDDIDDDWGDDDLAEDEDDEIEGEDQSDDETGSIDLQPLDDDDDDDDDDDDEGSISEGGPGDSDSSDAPESPDEEDDDDEDAPPRSKKSRKDSTDMVGGRSFAKTLKQSHDMSSLFAAADDFSSLLEETAKVKGQGTSNAVFNKDKSSDKQLKWEENRRSNSKSYKGKKFAGKPAAKGGRPQKAGKKRKH
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [396-677]
- IPR040155: CEBPZ/Mak21-like (family) [125-1172]
- IPR005612: CCAAT-binding factor (domain) [582-801]
Interaction partners: - Nucleolar complex protein 2
- rRNA biogenesis protein RRP5
- LD27920p
- Probable ATP-dependent RNA helicase pitchoune
- LD11307p
- Probable ATP-dependent RNA helicase DDX56
- RRM domain-containing protein
- Pescadillo homolog
- Ribosome production factor 2 homolog
- Nucleolar complex protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005667 (transcription regulator complex), GO:0090575 (RNA polymerase II transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0016602 (CCAAT-binding factor complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)