Protein: Transmembrane protein 39B (Q7ZW11)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May protect the cells against DNA damage caused by exposure to the cold-warming stress and facilitates tissue damage repair during the recovery phase
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MAGGRRGANRTTYCRSPLSNDTGSVGNGNHSTSSPVTGVRSRTRNGSGTGMSSPPLATQTVVPLKHCKIPELSMDKNVLFELHLFACHLIALFVHYVNIYKTVWWYPPSHPPSHTSLNFHLIDYNMLVFTVIVLARRLIAAIVKEASQSGKLSFPHSVFLVTARFAVLTLAGWSLCRSLIYLFKTYSVLSLLFLCYPFGMYIPFFRLSCDFRRAGSMSPLSGIGSKDVGAAALGRGGRDYLSVLKETWKQHTSQLYSAQPMPTHACCLSPDLIRKEVEYLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKSTQYVDKRWSCELFILVSVSTSVILMRHLLPPRYCDLLHKAAAHLGCWQKVDPSLCSNVLQHIWTEEYMWPQGVLVKHSKNVYKAMGHYNVAVPSDVSHYRFYFFFNKPLRILNILIILEGAMIFYQLYSLMCSEKWHQTISLALILFSNYYAFFKLLRDRIVLGKAYSYSASASNQKVS
InterPro domains: - IPR019397: Uncharacterised protein family TMEM39 (family) [1-488]
Interaction partners: - StAR-related lipid transfer (START) domain-containing 9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:0045596 (negative regulation of cell differentiation), GO:0060341 (regulation of cellular localization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0045595 (regulation of cell differentiation), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0045664 (regulation of neuron differentiation), GO:0007399 (nervous system development), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0032880 (regulation of protein localization), GO:0008589 (regulation of smoothened signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)