Protein: Protein distal antenna-related (Q9VBW9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:12571108}.
Sequence: MDISAYQHMNIRMSTRGKRPLRNLTPNDKVRAIQRIHNGETKASVSRDIGVPESTLRGWCKNEQKLRFMCRQLGPDHLGLDTPPEKRAKFELQLQLPPKFVALPPNYEELGFGALPYSPADYPVQNESLLEKLSLVEFVKKNGGLHPEGALHPGQAGVMDYSNNMLHQLNLLALLNSKLTPQTADVLVDAQPKSEDNKVIDSPAASEDYSKNNYPLLSVKNWAKDPAKRVNSANQPEQVNDKNNNALEANSSAPQALVTEQAKTPMFSDTTMPLLPAPFPNPADLAPVIAPVTPANAPPTGTDNQGAALLDWCKLFNASLNFLAFAAAAASMQPGGGGPGGPSYNPNQMASGGSEPDLETYPFNEALLKRLSPLAHSEASNESYCDSEPEDLSVRSCASKASSRSHTPDKSVGSSDAEQ
InterPro domains: - IPR051839: Retinal determination transcriptional regulator (family) [9-235]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [18-77]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [15-79]
- IPR007889: DNA binding HTH domain, Psq-type (domain) [15-69]
Interaction partners: - Protein distal antenna
- Homeobox protein homothorax
- Protein teashirt
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0021551 (central nervous system morphogenesis), GO:0048736 (appendage development), GO:0003002 (regionalization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007379 (segment specification), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0035107 (appendage morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0035282 (segmentation), GO:0007399 (nervous system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048737 (imaginal disc-derived appendage development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0007444 (imaginal disc development), GO:0010468 (regulation of gene expression), GO:0001654 (eye development), GO:0035214 (eye-antennal disc development), GO:0007469 (antennal development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0150063 (visual system development), GO:0048749 (compound eye development), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)