Protein: Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) (O14522)
Organism: Homo sapiens (Human)
Function: May be involved in both signal transduction and cellular adhesion in the CNS.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTWEKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGALNVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCVRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [863-1441]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1063-1428]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [287-584]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [192-295]
- IPR003961: Fibronectin type III (domain) [288-590]
- IPR000998: MAM domain (domain) [27-191]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [30-189]
- IPR057598: Receptor-type tyrosine-protein phosphatase U-like, Fn3 domain (domain) [586-727]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [190-591]
- IPR007110: Immunoglobulin-like domain (domain) [193-284]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1041-1436]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1082-1386]
- IPR051622: Receptor-type Tyrosine-protein Phosphatases (family) [22-811]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [888-1439]
Interaction partners: - 6-pyruvoyl tetrahydrobiopterin synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0019899 (enzyme binding), GO:0004725 (protein tyrosine phosphatase activity), GO:0019900 (kinase binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0006979 (response to oxidative stress), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0051726 (regulation of cell cycle), GO:0010632 (regulation of epithelial cell migration), GO:0042127 (regulation of cell population proliferation), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0010633 (negative regulation of epithelial cell migration), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0045786 (negative regulation of cell cycle), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0031589 (cell-substrate adhesion), GO:0016477 (cell migration), GO:2000146 (negative regulation of cell motility), GO:0034599 (cellular response to oxidative stress), GO:0071559 (response to transforming growth factor beta), GO:0010812 (negative regulation of cell-substrate adhesion), GO:0048145 (regulation of fibroblast proliferation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0051246 (regulation of protein metabolic process), GO:0062197 (cellular response to chemical stress), GO:0051248 (negative regulation of protein metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0006796 (phosphate-containing compound metabolic process), GO:0030334 (regulation of cell migration), GO:0050678 (regulation of epithelial cell proliferation), GO:0030336 (negative regulation of cell migration), GO:0022607 (cellular component assembly), GO:0007160 (cell-matrix adhesion), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0008104 (protein localization), GO:0051338 (regulation of transferase activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0051174 (regulation of phosphorus metabolic process), GO:0016311 (dephosphorylation), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0031399 (regulation of protein modification process), GO:0030031 (cell projection assembly), GO:0031400 (negative regulation of protein modification process), GO:0006470 (protein dephosphorylation), GO:0019220 (regulation of phosphate metabolic process), GO:0034329 (cell junction assembly), GO:0007010 (cytoskeleton organization), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0034614 (cellular response to reactive oxygen species), GO:0045936 (negative regulation of phosphate metabolic process), GO:0071364 (cellular response to epidermal growth factor stimulus), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0048008 (platelet-derived growth factor receptor signaling pathway), GO:0046777 (protein autophosphorylation), GO:0061097 (regulation of protein tyrosine kinase activity), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050732 (negative regulation of peptidyl-tyrosine phosphorylation), GO:0006469 (negative regulation of protein kinase activity), GO:0061099 (negative regulation of protein tyrosine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0030027 (lamellipodium), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction)