wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) (P97687)
Organism: Rattus norvegicus (Rat)
Function: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Subcellular location: Membrane {ECO:0000250|UniProtKB:P49961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49961}. Membrane, caveola {ECO:0000250|UniProtKB:P49961}.
Sequence: MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYISLMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
InterPro domains: - IPR000407: Nucleoside phosphatase GDA1/CD39 (family) [20-471]
Interaction partners: - 5'-nucleotidase
- Adenosine kinase
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
- Ectonucleoside triphosphate diphosphohydrolase 6
- Ectonucleoside triphosphate diphosphohydrolase 2
- Ectonucleoside triphosphate diphosphohydrolase 5
- AMP deaminase 2
- UMP-CMP kinase
- AMP deaminase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050896 (response to stimulus), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0097305 (response to alcohol), GO:0046688 (response to copper ion), GO:0045471 (response to ethanol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane)
Protein: Discoidin-1 subunit B/C (Discoidin I chain C/D) (Discoidin-1 subunit beta/gamma) (P02887)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Galactose- and N-acetylgalactosamine-binding lectin. May play a role in cell-substratum adhesion rather than in cell-cell adhesion. May be necessary for the maintenance of normal elongate morphology during aggregation.
Subcellular location: Cytoplasm.
Sequence: MSTQGLVQLISNAQCHLRTSTNYNDVHTQFNAVLNYKNKGTNTIDGSEAWCSSIVDTNQYIVAGCEVPRTFMCVALQGRGDHDQWVTSYKIRYSLDNVTWSEYRNGAAITGVTDRNTVVNHFFDTPIRARSIAIHPLTWNNHISLRCEFYTQPVQSSVTQVGADIYTGDNCALNTGSGKREVVVPVKFQFEFATLPKVALNFDQIDCTDATNQTRIGVQPRNITTKGFDCVFYTWNANKVYSLRADYIATALE
InterPro domains: - IPR000421: Coagulation factor 5/8, C-terminal domain (domain) [1-152]
- IPR052487: Galactose-binding lectin (family) [2-252]
- IPR037221: H-type lectin domain superfamily (homologous_superfamily) [155-253]
- IPR019019: H-type lectin domain (domain) [184-250]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [19-154]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030246 (carbohydrate binding), GO:0097367 (carbohydrate derivative binding), GO:0030247 (polysaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0071840 (cellular component organization or biogenesis), GO:0098609 (cell-cell adhesion), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0098636 (protein complex involved in cell adhesion), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle)
Protein: Putative cysteine transferase (Q83XN4)
Organism: Streptantibioticus cattleyicolor (Streptomyces cattleya)
Function: Not known
Sequence: MDPEAGSRARGLKGVHRVSANSGGIGGVPGPHNGLTDVPGVRVGHAGRTGDGWLTGVTVVLAPPGGAVAAVDVRGGGPGTRETDALDPRNLVQTIDAVVLTGGSAFGLDAAGGVAAWLEEQGRGFPVGADPSQVVPVVPAAALFDLGRGGTWRARPDAALGRAAVEAAAARPEGDPVEQGGVGAGTGAVVGGLKGGIGTASVVLDSGATVAALAAVNAAGSAVDPATGVLYGARTGLPGEFAGYGVPDAIGADTHARARARLAEAAEETARRRAGGAATLNTTLAVVATDATLTRAQAQKLAGTAHDGLARAVRPVHLLSDGDTVFALSTGRRPLLPDRPDATAARAFGVHLEAGALNEVLAAGADVLTRAVVHAVLAATGVDTPGGVHPSYRELYARP
InterPro domains: - IPR005321: Peptidase S58, DmpA (family) [28-388]
- IPR016117: ArgJ-like domain superfamily (homologous_superfamily) [25-383]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Formamidase (G5EB67)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MGTKAIRTAVKVDLNKPAREQKGLHNRWHPDIPSYGTIANNEVVKIECLDWTGGQIKNDDSADDIKNVDLTQIHYLSGPFDIETAEPGDVLLVEIQDVQPFEDQPWGFTGVFARENGGGFLDEIYPEPAKAIWDFEGIFCSSRHIPHVRFAGLIHPGILGCAPSAEVLAEWNRREGELIAANTLGRDVAKPPEPSNVHAGSADGELAAKIGREGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGVITLKFTVIKDGMAKMAMKSPIFHPGPVEPQFGPGRYLTFEGFSVDEKGKQHYLDATVAYRQTCLRVIEYLRRYGYNDYQIYLLLSCAPVQGHIAGLVDIPNACTTLGVPMDIFDFDIRPEADAVKLDMGSCAFASK
InterPro domains: - IPR054833: Acetamidase/formamidase family (family) [8-399]
- IPR004304: Acetamidase/Formamidase (family) [3-394]
Interaction partners: - Glutamine synthetase
- CN hydrolase domain-containing protein
- Nitrilase
- Cyanide hydratase
- Glutamine synthetase
- NADP-specific glutamate dehydrogenase
- NAD-specific glutamate dehydrogenase
- Nitrite reductase [NAD
- Formate dehydrogenase
- Cupin type-1 domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0019748 (secondary metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Complement C8 gamma chain (A0A8I6A1Y6)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MWTSGLCFLWHWTVDSDLEQCTPPPPCPITYCHRTAMLSPGAVLFFTLILMASSLGQRTRKPYGSTSPISTIQAQANFNAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHIAPQGAAMAASTFRKLDGICWQVRQLYGITGVPGRFLLQAPRARGPVHVVVAETDYQSFAILYLEQARRLSVKLYTRTLPVSDSALNAFEERVRGANLTEDQIFFFPKYGFCETADQFHILNGECQQGRAVGWRG
InterPro domains: - IPR012674: Calycin (homologous_superfamily) [57-238]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [84-220]
- IPR022272: Lipocalin family conserved site (conserved_site) [77-90]
- IPR002968: Alpha-1-microglobulin (family) [75-228]
- IPR043245: Complement component C8 gamma chain (family) [18-234]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0001848 (complement binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009743 (response to carbohydrate), GO:0034284 (response to monosaccharide), GO:0009746 (response to hexose), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: GH14758p (Q95SM0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKAS
InterPro domains: - IPR003439: ABC transporter-like, ATP-binding domain (domain) [1-170]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [73-87]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-172]
- IPR039421: Type 1 protein exporter (family) [2-167]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Calcium sensing receptor, chloroplastic (Sulfurtransferase 3) (AtStr3) (Q9FN48)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Modulates cytoplasmic Ca(2+) concentration and is crucial for proper stomatal regulation in response to elevated levels of external Ca(2+). May function by regulating concentrations of inositol 1,4,5-trisphosphate (IP3), which in turn triggers release of Ca(2+) from internal stores. May play a role in de-etiolation.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000269|PubMed:18331354, ECO:0000269|PubMed:18507772}; Single-pass membrane protein {ECO:0000269|PubMed:18331354, ECO:0000269|PubMed:18507772}; Stromal side {ECO:0000269|PubMed:18331354, ECO:0000269|PubMed:18507772}.
Sequence: MAMAEMATKSSLSAKLTLPSSSTKKTLSLRQVSVSLPTSTSISLLSLFASPPHEAKAAVSIPKDQIVSSLTEVEKTINQVQETGSSVFDATQRVFQVVGDALKPALDTALPIAKQAGEEAMKLASPAFSEASKKAQEAMQSSGFDSEPVFNAAKTVTDVAQQTSKAIEDAKPIASSTMDTISSADPSVIVVAAGAAFLAYLLLPPVFSAISFNFRGYKGDLTPAQTLDLLCTKNYLMVDIRSEKDKEKAGIPRLPSNAKNRVISIPLEELPNKVKGIVRNSKRVEAEIAALKISYLKKINKGSNIIILDSYTDSAKIVAKTLKVLGYKNCYIVTDGFSGGRGWLQSRLGTDSYNFSFAQVLSPSRIIPAASRSFGTRSGTKFLPSSD
InterPro domains: - IPR001763: Rhodanese-like domain (domain) [223-352]
- IPR044690: Calcium sensing receptor, plant (family) [25-350]
- IPR036873: Rhodanese-like domain superfamily (homologous_superfamily) [207-357]
Interaction partners: - AP-2 complex subunit sigma
- AP-2 complex subunit alpha-2
- AP-2 complex subunit alpha-1
- Uncharacterized protein At1g03900
- Adaptin ear-binding coat-associated protein 1 NECAP-1
- Beta-adaptin-like protein B
- Beta-adaptin-like protein A
- 50S ribosomal protein L27
- Beta-adaptin-like protein C
- At5g57460
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015979 (photosynthesis), GO:0022900 (electron transport chain), GO:0019684 (photosynthesis, light reaction), GO:0009767 (photosynthetic electron transport chain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0009536 (plastid), GO:0043227 (membrane-bounded organelle), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0031968 (organelle outer membrane), GO:0031969 (chloroplast membrane), GO:0009941 (chloroplast envelope), GO:0009527 (plastid outer membrane), GO:0009707 (chloroplast outer membrane)
Protein: Stellate protein CG33236/CG33240/CG33244/CG33245 (Q7KV12)
Organism: Drosophila melanogaster (Fruit fly)
Function: Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.
Sequence: MSSSQNNNSSWIDWFLGIKGNQFLCRVPTDYVQDTFNQMGLEYFSEILDVILKPVIDSSSGLLYGDEKKWYGMIHARYIRSERGLIAMHRKYLRGDFGSCPNISCDRQNTLPVGLSAVWGKSTVKIHCPRCKSNFHPKSDTQLDGAMFGPSFPDIFFSMLPNLTSPLDDPRT
InterPro domains: - IPR016149: Casein kinase II, regulatory subunit, N-terminal (homologous_superfamily) [3-96]
- IPR035991: Casein kinase II subunit beta-like (homologous_superfamily) [9-165]
- IPR000704: Casein kinase II, regulatory subunit (family) [2-167]
Interaction partners: - Casein kinase II subunit alpha
- Casein kinase II subunit beta
- Stellate protein CG33246
- Segment polarity protein dishevelled
- Stellate protein CG33243
- Ste:CG33242
- Stellate protein CG33247
- Stellate protein CG33238
- Stellate protein CG33237
- Stellate protein CG33239/CG33241
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0019207 (kinase regulator activity), GO:0019887 (protein kinase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0010921 (regulation of phosphatase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0043666 (regulation of phosphoprotein phosphatase activity), GO:0035303 (regulation of dephosphorylation), GO:0035304 (regulation of protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0005956 (protein kinase CK2 complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005634 (nucleus), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex)
Protein: L-erythrulose 1-kinase (EC 2.7.1.209) (A0R758)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Kinase that has a preference for L-erythrulose, producing L-erythrulose-1P. Involved in the degradation pathway of L-threitol, that allows M.smegmatis to grow on this compound as the sole carbon source. Is also able to phosphorylate D-erythrulose and dihydroxyacetone in vitro.
Sequence: MTYLLNSPDDFADEAVRGLVAANPDLLTEVPGGVVRSTETPKGQPALVIGGGSGHYPAFAGWVGPGMGHGAPCGNIFSSPSASEVYSVVRNAENGGGVILGFGNYAGDVLHFGLAAEKLRHEGIDVRIVTVSDDIASNSPENHRDRRGVAGDLPVFKIAGAAIEAGADLDEAERVAWKANDATRSFGLAFEGCTLPGATEPLFHVEKGWMGVGLGIHGEPGVRDNRLGTAAEVADMLFDEVTAEEPPRGENGYDGRVAVILNGLGTVKYEELFVVYGRIAERLAQQGFTVVRPEVGEFVTSLDMAGVSLTMVFLDDELERLWTAPVETPAYRRGAMPAVDRTPRTTTWDAAETTIPEASEGSRECARNIVAVLETFQQVCADNEAELGRIDAVAGDGDHGQGMSFGSRGAAQAARDAVDRNAGARTTLLLAGQAWADAAGGTSGALWGAALTSAGGVFSDTDGADEQAAVDAICAGIDAILRLGGAQPGDKTMVDAAVPFRDALVKAFDTQAGPAITSAARVAREAAEKTADITARRGRARVLGEKSVGTPDPGALSFAMLMKALGEHLTR
InterPro domains: - IPR004006: DhaK domain (domain) [7-331]
- IPR036117: DhaL domain superfamily (homologous_superfamily) [364-568]
- IPR050861: Dihydroxyacetone Kinase (DAK) (family) [6-569]
- IPR004007: DhaL domain (domain) [367-567]
Interaction partners: - Phosphocarrier protein HPr
- D-erythrulose-4-phosphate isomerase 2
- L-erythrulose-1-phosphate isomerase
- AP endonuclease, family protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0030246 (carbohydrate binding), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016301 (kinase activity), GO:0019200 (carbohydrate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901700 (response to oxygen-containing compound), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009743 (response to carbohydrate), GO:0016052 (carbohydrate catabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0071310 (cellular response to organic substance), GO:0031667 (response to nutrient levels), GO:0071322 (cellular response to carbohydrate stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40) (Q8N1N4)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSLSPCRAQRGFSARSACSARSRGRSRGGFSSRGGFSSRSLNSFGGCLEGSRGSTWGSGGRLGVRFGEWSGGPGLSLCPPGGIQEVTINQNLLTPLKIEIDPQFQVVRTQETQEIRTLNNQFASFIDKVRFLEQQNKVLETKWHLLQQQGLSGSQQGLEPVFEACLDQLRKQLEQLQGERGALDAELKACRDQEEEYKSKYEEEAHRRATLENDFVVLKKDVDGVFLSKMELEGKLEALREYLYFLKHLNEEELGQLQTQASDTSVVLSMDNNRYLDFSSIITEVRARYEEIARSSKAEAEALYQTKYQELQVSAQLHGDRMQETKVQISQLHQEIQRLQSQTENLKKQNASLQAAITDAEQRGELALKDAQAKVDELEAALRMAKQNLARLLCEYQELTSTKLSLDVEIATYRRLLEGEECRMSGECTSQVTISSVGGSAVMSGGVGGGLGSTCGLGSGKGSPGSCCTSIVTGGSNIILGSGKDPVLDSCSVSGSSAGSSCHTILKKTVESSLKTSITY
InterPro domains: - IPR018039: Intermediate filament protein, conserved site (conserved_site) [410-418]
- IPR003054: Keratin, type II (family) [113-378]
- IPR032444: Keratin type II head (domain) [51-107]
- IPR039008: Intermediate filament, rod domain (domain) [110-424]
Interaction partners: - Keratinocyte proline-rich protein
- Cornulin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0045103 (intermediate filament-based process), GO:0045104 (intermediate filament cytoskeleton organization), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043230 (extracellular organelle), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:1903561 (extracellular vesicle), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton), GO:0045095 (keratin filament)