Protein: Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206) (P22897)
Organism: Homo sapiens (Human)
Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}. Cell membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}.
Sequence: MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGCVAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI
InterPro domains: - IPR000772: Ricin B, lectin domain (domain) [22-150]
- IPR013806: Kringle-like fold (homologous_superfamily) [153-211]
- IPR036943: Fibronectin type II domain superfamily (homologous_superfamily) [155-210]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [219-1361]
- IPR018378: C-type lectin, conserved site (conserved_site) [316-1355]
- IPR050111: C-type lectin and snaclec domain-containing protein (family) [25-650]
- IPR016187: C-type lectin fold (homologous_superfamily) [230-1359]
- IPR001304: C-type lectin-like (domain) [216-1357]
- IPR000562: Fibronectin type II domain (domain) [161-211]
- IPR035992: Ricin B-like lectins (homologous_superfamily) [22-153]
Interaction partners: - WD repeat and HMG-box DNA-binding protein 1
- Protein MCM10 homolog
- Cell division control protein 45 homolog
- Integrin alpha-M
- Scavenger receptor cysteine-rich type 1 protein M130
- C-type mannose receptor 2
- TIMELESS-interacting protein
- Secretory phospholipase A2 receptor
- Arginase-1
- Macrosialin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0048029 (monosaccharide binding), GO:0005537 (mannose binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0009611 (response to wounding), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:1901135 (carbohydrate derivative metabolic process), GO:0022008 (neurogenesis), GO:0042060 (wound healing), GO:0007399 (nervous system development), GO:1901565 (organonitrogen compound catabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:1901136 (carbohydrate derivative catabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0030163 (protein catabolic process), GO:0042981 (regulation of apoptotic process), GO:1901657 (glycosyl compound metabolic process), GO:0014070 (response to organic cyclic compound), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048678 (response to axon injury), GO:0031103 (axon regeneration), GO:0042981 (regulation of apoptotic process), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0043066 (negative regulation of apoptotic process), GO:0030203 (glycosaminoglycan metabolic process), GO:0043066 (negative regulation of apoptotic process), GO:1904036 (negative regulation of epithelial cell apoptotic process), GO:1904035 (regulation of epithelial cell apoptotic process), GO:2000351 (regulation of endothelial cell apoptotic process), GO:2000352 (negative regulation of endothelial cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)