Protein: 5'-3' exoribonuclease 1 (D4ABN8)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSALKEKITFKYDIEKIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYIAILPELGGYINESGHLNLPRFERYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGAAAEEAKSCKDKRKVKGQENSLSWAALDKREGEGVASRDNFEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDEFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIRNISTLKIHFELGKPFKPFEQLLAVLPSASKTLLPTCYQHLMTSEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDSDTEFTYSSPWPEKFPAIERCSTRYKIISLDAWRVDINKNKITRVDQKALYFCGFPTLKHIKHKFFLKKSGVQVFQQSSRGENMMLEITVNAEPDELSIENIASSVLGKSVFVNWPHLEEARVVAVSDGETKFYMEEPPGTQKVYLGKTAPPCKVIQLSDKEQSNWTKEIQGISEQYLRRKGIMINETSAVVYAQLLTGRRYQVNQNGEVRLEKQWSKQSLPFVYQTIVKDVRAFDSRFSNIKTLDDLFPPRSVVFMLGTPYYGCTGEVQDSGDVITEGRIRVVFSIPCEPNLDALIQNQHKYSIKYNPGYVLAGRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKRVGSEWMYSSAAEQLLAEYIERAPELFSYIAQNSQEDVFYEDDIWPGESESGAEKVQEIITWLKGHPVSTLSRSSCDLHILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLFRPLEQQHGAIPDRDAEFRLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRCETGNQKLTAIVKPQPAVSHCSVNSSVSSGHMGGLNHSPQSLFLPTQVPTKGDDEFCNIWQSLQGSGKIQHLQPTVQEKGAVLPQEISQVTESHKSGFNDHSVRHQQRKHDPHRKFKEEYKSPKAECQNQKLSNKQTSGASARCNIKLLKRNESPGTSEAQKVVTSYPNAVHKPHSGIESFLASLNISKESEVQLPHGEPPDEAHLSPQSFAMKGTRMLKEILKIDSPDTTDSKNDVKKFDNEVMVSSSRRDEHGPSSHPKPSKKLASHVSQPHSTNEYQSVDSVCWPGHMPPVSTPVTELSRICSLVGMPQPDFSFLRTTQTMTVCQVKLSNGLLVHGPQCHSESEAKERAALFALQQLGSLGVNFPLPPPIFTNYPPAVPPGAVPPVFPQPTANMMPSSSHLFGSVPWRPPVPVPGNAYHYPSYPATMPLAGGMPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPLQTNKPGSSEATRMTPQEGSPASSASSQATQPVSSHVETASQGHVVSHQRSAPSSSRRKSRKLAVNFSVSKPSE
InterPro domains: - IPR027073: 5'-3' exoribonuclease (family) [1-1178]
- IPR041106: Exoribonuclease Xrn1, D2/D3 domain (domain) [850-1075]
- IPR047007: 5'-3' exoribonuclease 1, D1 domain superfamily (homologous_superfamily) [662-845]
- IPR004859: Xrn1, N-terminal (domain) [1-227]
- IPR047008: 5'-3' exoribonuclease 1, SH3-like domain superfamily (homologous_superfamily) [1088-1187]
- IPR016494: 5'-3' exoribonuclease 1 (family) [1-1723]
- IPR041412: Xrn1, helical domain (domain) [272-597]
- IPR040992: 5'-3' exoribonuclease 1, D1 domain (domain) [654-844]
- IPR041385: 5'-3' exoribonuclease 1, SH3-like domain (domain) [1101-1171]
Interaction partners: - Decapping mRNA 2
- 5'-
- Protein PAT1 homolog 1
- U6 snRNA-associated Sm-like protein LSm1
- 5'-3' exoribonuclease
- Enhancer of mRNA-decapping protein 3
- PAT1 homolog 2
- H/ACA ribonucleoprotein complex subunit DKC1
- RNA helicase
- Superkiller complex protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0000723 (telomere maintenance), GO:0006396 (RNA processing), GO:0051276 (chromosome organization), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0032200 (telomere organization), GO:0090503 (RNA phosphodiester bond hydrolysis, exonucleolytic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0043025 (neuronal cell body), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0000932 (P-body), GO:0043232 (intracellular non-membrane-bounded organelle)