Protein: Sodium/potassium/calcium exchanger 1 (Q9QZM6)
Organism: Rattus norvegicus (Rat)
Function: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MGKLIRMGTQERRLLRPKRLHWSRLLFFLGMLIIGSTYQHLRRPQNPPSMWTKVSSQQPIKLAIRDLPNDEITVTDKDPPEASSEVEGEMLAPQDTVIIGEAAPSIAMEDTPNPPITTKITPTSLKNNYSPTTAGTRRQKENIPPTPSRAPSHFISTSGRQRVKSYTPKPRGGRKSSSPTHTREEGRMHTPSPAGAPRTISPTSTEKDSETTATYRMLEPRSERTAGKTSLKRMVPNTRTFLTREVETDLVTSPSLVGKNTLGSPRRGERNSSTTPLRAVLQPTPATSEEQVTASIRMGSTPATTEGSTAAQRIGNPLSGTSTPAVRIASVTDREKRPSTAHGTLVTPQVKAVLTTQVHRCVVVKPAPAVPMTPSPSMTAILFPEAPTSGPSALPPGWPNLHPKAEYPPDLFSVEDRRQGWVVLHIFGMTYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLSMLIVFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIERWVKEQLSRRPVAKVMALGDLSKPSDGAIEENEQQDNKKLKLPSVLTRGSSSASLHNSIIRSTIYHLMLHSLDPLGEARPSKDKQESLNQEARVLPQTKAESSSDEEEPAELPAVTVTPAPAPEDKGDQEEDPGCQEDVDEAEHRGDMTGEEGERETEAEGKKDEEGETEAERKEDGQEEETETKGKEKQEGETESEGKDEQEGETEAEGKEADHEGETEAEGKEVEHEGETEAEGTEDEQEGETEAEGKEVEQEGETEAEGKEVEHEVETEAERKETNHEGETEAEGKEADHEGETEAEGNVEHQGETEAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDGEGEAEANAEDQCETAQGEKGADGGGGSDGGDSEEEEDEEDEEEEEEEEEEEEEEESEEPLSLEWPESRQKQAIYLFLLPIVFPLWLTIPDVRRQEARKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINALQPIPVSSNGLFCAIVLLFLMLLFVIFSIASCKWRMNKILGFTMFLLYFVFLVISVMLEDRIISCPVSV
InterPro domains: - IPR004817: Sodium/potassium/calcium exchanger 1 (family) [1-1181]
- IPR004481: Sodium/potassium/calcium exchanger (family) [24-1181]
- IPR004837: Sodium/calcium exchanger membrane region (domain) [426-1168]
- IPR044880: NCX, central ion-binding domain superfamily (homologous_superfamily) [457-1169]
Interaction partners: - Potassium voltage-gated channel subfamily V member 2
- Phosphodiesterase
- Rod outer segment membrane protein 1
- Cyclic nucleotide-gated channel alpha-1
- Phosphodiesterase
- Cyclic nucleotide-gated channel alpha-3
- Photoreceptor-specific nuclear receptor
- Regulator of G protein signaling 9 binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015368 (calcium:monoatomic cation antiporter activity), GO:0022821 (solute:potassium antiporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005432 (calcium:sodium antiporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0071702 (organic substance transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0070588 (calcium ion transmembrane transport), GO:0006816 (calcium ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)