Protein: Cullin 2 (A0A0G2K761)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYAETKIFLENHVRHLYKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHSECHSIIRHERKNDMANMYVLLRAVSSGLPHMIEELQRHIHDEGLRATSNLTQEHMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA
InterPro domains: - IPR036317: Cullin homology domain superfamily (homologous_superfamily) [382-654]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [662-706]
- IPR045093: Cullin (family) [11-659]
- IPR016158: Cullin homology domain (domain) [386-618]
- IPR001373: Cullin, N-terminal (domain) [14-644]
- IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [10-380]
- IPR016157: Cullin, conserved site (conserved_site) [679-706]
- IPR019559: Cullin protein, neddylation domain (domain) [645-700]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [661-706]
Interaction partners: - Elongin-C
- von Hippel-Lindau disease tumor suppressor
- Elongin-B
- E3 ubiquitin-protein ligase RBX1
- Elongin-B
- Hypoxia-inducible factor 1-alpha
- Ubiquitin-like protein NEDD8
- Leucine-rich repeat protein 1
- Protein zer-1 homolog
- Endothelial PAS domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0044877 (protein-containing complex binding), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0030163 (protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0000153 (cytoplasmic ubiquitin ligase complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex)