Protein: Sorcin (22 kDa protein) (CP-22) (V19) (P05044)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the sarcoplasmic reticulum in the heart. Modulates the activity of RYR2 calcium channels.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15754088}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15754088}; Peripheral membrane protein {ECO:0000269|PubMed:15754088}; Cytoplasmic side {ECO:0000269|PubMed:15754088}. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels and phosphorylation.
Sequence: MAYPGHPGAGGGYYPGGYGGAPGGPSFPGQTQDPLYGYFASVAGQDGQIDADELQRCLTQSGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDSDRSGTVDPQELQKALTTMGFRLNPQTVNSIAKRYSTSGKITFDDYIACCVKLRALTDSFRRRDSAQQGMVNFSYDDFIQCVMTV
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [33-196]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [113-125]
- IPR002048: EF-hand domain (domain) [45-135]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051129 (negative regulation of cellular component organization), GO:0060548 (negative regulation of cell death), GO:0060341 (regulation of cellular localization), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:0098771 (inorganic ion homeostasis), GO:0032970 (regulation of actin filament-based process), GO:0043462 (regulation of ATP-dependent activity), GO:0055082 (intracellular chemical homeostasis), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0051301 (cell division), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0030104 (water homeostasis), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:1904377 (positive regulation of protein localization to cell periphery), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0098801 (regulation of renal system process), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0032956 (regulation of actin cytoskeleton organization), GO:0032880 (regulation of protein localization), GO:1902532 (negative regulation of intracellular signal transduction), GO:0006873 (intracellular monoatomic ion homeostasis), GO:1905477 (positive regulation of protein localization to membrane), GO:0055074 (calcium ion homeostasis), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0051223 (regulation of protein transport), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0033043 (regulation of organelle organization), GO:0007417 (central nervous system development), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0043269 (regulation of monoatomic ion transport), GO:0031648 (protein destabilization), GO:0010638 (positive regulation of organelle organization), GO:1902531 (regulation of intracellular signal transduction), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0043408 (regulation of MAPK cascade), GO:0042981 (regulation of apoptotic process), GO:0051493 (regulation of cytoskeleton organization), GO:1905475 (regulation of protein localization to membrane), GO:0051494 (negative regulation of cytoskeleton organization), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0048193 (Golgi vesicle transport), GO:1905475 (regulation of protein localization to membrane), GO:0051494 (negative regulation of cytoskeleton organization), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043066 (negative regulation of apoptotic process), GO:0006874 (intracellular calcium ion homeostasis), GO:0090201 (negative regulation of release of cytochrome c from mitochondria), GO:0090199 (regulation of release of cytochrome c from mitochondria), GO:0010823 (negative regulation of mitochondrion organization), GO:0043409 (negative regulation of MAPK cascade), GO:1903076 (regulation of protein localization to plasma membrane), GO:0006898 (receptor-mediated endocytosis), GO:0030833 (regulation of actin filament polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0030018 (Z disc), GO:0071944 (cell periphery), GO:0031984 (organelle subcompartment), GO:0030315 (T-tubule), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0099080 (supramolecular complex), GO:0031090 (organelle membrane), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043228 (non-membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0099081 (supramolecular polymer), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0033017 (sarcoplasmic reticulum membrane), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)