Protein: Small ubiquitin-related modifier 2 (SUMO-2) (SMT3 homolog 2) (Sentrin-2) (Ubiquitin-like protein SMT3A) (Smt3A) (P61959)
Organism: Rattus norvegicus (Rat)
Function: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
Sequence: MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
InterPro domains: - IPR022617: Rad60/SUMO-like domain (domain) [18-86]
- IPR000626: Ubiquitin-like domain (domain) [16-93]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-93]
Interaction partners: - E3 SUMO-protein ligase RanBP2
- SUMO-conjugating enzyme UBC9
- Tyrosyl-DNA phosphodiesterase 2
- E3 SUMO-protein ligase PIAS4
- Ran GTPase-activating protein 1
- Cellular tumor antigen p53
- SUMO-activating enzyme subunit 1
- Small ubiquitin-related modifier 1
- Protein kinase C zeta type
- SUMO specific peptidase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0019222 (regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0036211 (protein modification process), GO:0051247 (positive regulation of protein metabolic process), GO:0043412 (macromolecule modification), GO:0051246 (regulation of protein metabolic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0031401 (positive regulation of protein modification process), GO:0031399 (regulation of protein modification process), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:0031396 (regulation of protein ubiquitination), GO:0016567 (protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)