Protein: Oxidoreductase PigB (EC 1.-.-.-) (Q5W270)
Organism: Serratia sp. (strain ATCC 39006) (Prodigiosinella confusarubida)
Function: Involved in the biosynthesis of 2-methyl-3-n-amyl-pyrrole (MAP), one of the terminal products involved in the biosynthesis of the red antibiotic prodigiosin (Pig). Catalyzes the oxidation of dihydro form of MAP (H2MAP) to yield MAP.
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MIIQRLFGILYMLAGLAKAFPQFENVPAVLRQAAIANQGTWYAAASIWLGAHGDVINILVGVVLFGSGVILMLNPLWTTLVIYAQLLMMAVFVVILHQSQPQVMLLDGVFALAALYMLRGQYHRKPKPRTFPTTSFSLPTPSSESSFSAPLGDEYDVVIIGGGASGLTAASEFTHERVLVLEKSSTFGGNARYHTFNRLKHPTAGVCFQEPFPGSNMLRLLKKIGLEGKYKSNEKDTLVFFDTFLLLKCLGEIVVGFIKQPRYLLKLSVWGLTSQLFLHAIIGKPYVVAAKQLGDPIFADLYTFLDKFSPRGDFYPRLPWTPNGSWSKAHMELLDNISLYTYLFEPDKLGRLPEQLRPPARLGKLVENAVSTTLRVECLDIHDVSAYVGLHFLVGYLRGNLVTLPGGNGSISAGLCKYLSHQRNVTLQNHVQLTAVEPQHNGTCIQFTINGQPRQVQAQQIIWAAPKTQLATWLPGLPAKQLAAIKNIRHEDYYLANVFLSKPVLGHSFGGYMIEPDSNKDPFSWCKAGTCLVANWMDDHADVDVGVLTLLKPTTRSERQDRTAQNAFLALQQQTYAEIAKVLRNIGIGAEVIEDIQIWYWPAGLVTSVVGQQAEGVFETARQSFENIHFANQDSVGVGNIESAILSGIDAANAVKAQLMDTENVVEVAG
InterPro domains: - IPR046104: Protein of unknown function DUF6041 (family) [1-137]
- IPR002937: Amine oxidase (domain) [165-655]
- IPR050703: Flavin Monoamine Oxidase (family) [154-660]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [149-660]
Interaction partners: - Prodigiosin synthesizing transferase PigC
- Aminotransferase PigE
- Uroporphyrinogen decarboxylase
- Ferrochelatase
- Probable NAD
- L-prolyl-[peptidyl-carrier protein] dehydrogenase
- S-adenosyl-L-methionine-dependent methyl transferase PigF
- Oxygen-dependent coproporphyrinogen-III oxidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016634 (oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0120254 (olefinic compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0009404 (toxin metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0018904 (ether metabolic process), GO:0030638 (polyketide metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1902652 (secondary alcohol metabolic process), GO:1901503 (ether biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043385 (mycotoxin metabolic process), GO:0120255 (olefinic compound biosynthetic process), GO:0009403 (toxin biosynthetic process), GO:1902644 (tertiary alcohol metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0042181 (ketone biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0030639 (polyketide biosynthetic process), GO:0018958 (phenol-containing compound metabolic process), GO:0043386 (mycotoxin biosynthetic process), GO:1902645 (tertiary alcohol biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process), GO:0046189 (phenol-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)