Protein: Probable serine/threonine-protein phosphatase PP2A regulatory subunit (Protein phosphatase PP2A regulatory subunit A) (Q09543)
Organism: Caenorhabditis elegans
Function: Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras-MAP kinase signaling, probably by promoting lin-45 activation. Plays a positive role in axon guidance probably by inhibiting phosphatase let-92.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23336080}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23336080}. Note=Localizes to P granules in embryonic cells. {ECO:0000269|PubMed:23336080}.
Sequence: MSVVEEATDDALYPIAVLIDELRNEDVTLRLNSIRKLSTIALALGVERTRNELIQFLTDTIYDEDEVLLVLAEQLGNFTPLVGGPDHVHCLLLPLENLATVEETVVRDKAVESLRKIADKHSSASLEEHFVPMLRRLATGDWFTSRTSACGLFSVVYPRVSPAIKSELKSMFRTLCRDDTPMVRRAAAAKLGEFAKVFEKTAVIEGLHSSLTDLHVDEQDSVRLLTVESAIAFGTLLDKANKKKLIEPILIELFDDKSWRVRYMVAEKLIEIQNVLGEDMDTTHLVNMYTNLLKDPEGEVRCAATQRLQEFALNLPEDKRQNIICNSLLNVAKELVTDGNQLVKSELAGVIMGLAPLIGKEQTVSELLPIYMQLLNDQTPEVRLNIISSLDKVNEVIGAAQLSTSLLPAIVGLAEDGKWRVRLAIVQFMPLLASQLGQEFFDEKLLPLCLNWLTDHVFSIREASTLIMKELTQKFGGQWASTNIVPKMQKLQKDTNYLQRMTCLFCLNTLSEAMTQEQILKEIMPIVKDLVEDDVPNVRFNAAKSLKRIGKNLTPSTLTSEVKPLLEKLGKDSDFDVRYFSEEAKNSLGL
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [12-587]
- IPR051023: Protein Phosphatase 2A Regulatory Subunit A (family) [6-586]
- IPR021133: HEAT, type 2 (repeat) [14-561]
- IPR054573: Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat (domain) [280-359]
- IPR000357: HEAT repeat (repeat) [171-552]
- IPR011989: Armadillo-like helical (homologous_superfamily) [5-589]
Interaction partners: - Serine/threonine-protein phosphatase 2A catalytic subunit
- Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
- Serine/threonine protein phosphatase 2A regulatory subunit
- Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
- Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1
- Serine/threonine-protein phosphatase 2A activator
- EF-hand domain-containing protein
- Striatin N-terminal domain-containing protein
- Probable protein phosphatase methylesterase 1
- EF-hand domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:2000241 (regulation of reproductive process), GO:0007163 (establishment or maintenance of cell polarity), GO:0048584 (positive regulation of response to stimulus), GO:0022402 (cell cycle process), GO:0051240 (positive regulation of multicellular organismal process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:1903046 (meiotic cell cycle process), GO:0007017 (microtubule-based process), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0009967 (positive regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:1903047 (mitotic cell cycle process), GO:0030010 (establishment of cell polarity), GO:0080134 (regulation of response to stress), GO:0007051 (spindle organization), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0045132 (meiotic chromosome segregation), GO:0007062 (sister chromatid cohesion), GO:0000226 (microtubule cytoskeleton organization), GO:0045184 (establishment of protein localization), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:0061983 (meiosis II cell cycle process), GO:0140013 (meiotic nuclear division), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0051231 (spindle elongation), GO:0070727 (cellular macromolecule localization), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0000212 (meiotic spindle organization), GO:0010647 (positive regulation of cell communication), GO:0007143 (female meiotic nuclear division), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0098813 (nuclear chromosome segregation), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0140014 (mitotic nuclear division), GO:0007135 (meiosis II), GO:2001235 (positive regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:2001020 (regulation of response to DNA damage stimulus), GO:0009948 (anterior/posterior axis specification), GO:0051983 (regulation of chromosome segregation), GO:0051225 (spindle assembly), GO:0006886 (intracellular protein transport), GO:0051293 (establishment of spindle localization), GO:0007292 (female gamete generation), GO:0033043 (regulation of organelle organization), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051177 (meiotic sister chromatid cohesion), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0045144 (meiotic sister chromatid segregation), GO:1902531 (regulation of intracellular signal transduction), GO:0045144 (meiotic sister chromatid segregation), GO:0016311 (dephosphorylation), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0010965 (regulation of mitotic sister chromatid separation), GO:0033045 (regulation of sister chromatid segregation), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0007010 (cytoskeleton organization), GO:0000819 (sister chromatid segregation), GO:0000132 (establishment of mitotic spindle orientation), GO:0033044 (regulation of chromosome organization), GO:1901976 (regulation of cell cycle checkpoint), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0044297 (cell body), GO:1902494 (catalytic complex), GO:0030427 (site of polarized growth), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0043025 (neuronal cell body), GO:1903293 (phosphatase complex), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0030426 (growth cone), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043005 (neuron projection), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0008287 (protein serine/threonine phosphatase complex), GO:0044295 (axonal growth cone), GO:0005856 (cytoskeleton), GO:0000159 (protein phosphatase type 2A complex), GO:0030424 (axon), GO:0015630 (microtubule cytoskeleton)