Protein: Syntaxin-3 (Q08849)
Organism: Rattus norvegicus (Rat)
Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. Apical receptor involved in membrane fusion of apical vesicles. Essential for survival of retinal photoreceetors.
Subcellular location: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Localized to the inner and outer plexiform layers, the cell body and the inner segments of photoreceptors. {ECO:0000250|UniProtKB:Q64704}.
Sequence: MKDRLEQLKAKQLTQDDDTDEVEIAIDNTAFMDEFFSEIEETRLNIDKISEHVEEAKKLYSIILSAPIPEPKTKDDLEQLTTEIKKRANNVRNKLKSMEKHIEEDEVRSSADLRIRKSQHSVLSRKFVEVMTKYNEAQVDFRERSKGRIQRQLEITGKKTTDEELEEMLESGNPAIFTSGIIDSQISKQALSEIEGRHKDIVRLESSIKELHDMFMDIAMLVENQGEMLDNIELNVMHTVDHVEKARDETKRAMKYQGQARKKLIIIIVIVVVLLGILALIIGLSVGLK
InterPro domains: - IPR006011: Syntaxin, N-terminal domain (domain) [27-181]
- IPR031186: Syntaxin-3, SNARE motif (domain) [190-257]
- IPR045242: Syntaxin (family) [29-271]
- IPR000727: Target SNARE coiled-coil homology domain (domain) [186-278]
- IPR006012: Syntaxin/epimorphin, conserved site (conserved_site) [197-237]
- IPR010989: SNARE (homologous_superfamily) [31-246]
Interaction partners: - Vesicle-associated membrane protein 2
- Synaptosomal-associated protein 23
- Vesicle-associated membrane protein 8
- Syntaxin-binding protein 1
- Vesicle-associated membrane protein 3
- Vesicle-associated membrane protein 4
- Vesicle-associated membrane protein 1
- Syntaxin-binding protein 2
- Vesicle-trafficking protein SEC22b
- Synaptosomal-associated protein 29
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0000149 (SNARE binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0031503 (protein-containing complex localization), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0140352 (export from cell), GO:0033036 (macromolecule localization), GO:0048167 (regulation of synaptic plasticity), GO:0099637 (neurotransmitter receptor transport), GO:0050806 (positive regulation of synaptic transmission), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0010647 (positive regulation of cell communication), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0099177 (regulation of trans-synaptic signaling), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0097120 (receptor localization to synapse), GO:0098969 (neurotransmitter receptor transport to postsynaptic membrane), GO:0006887 (exocytosis), GO:0071705 (nitrogen compound transport), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0015031 (protein transport), GO:0050804 (modulation of chemical synaptic transmission), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0098877 (neurotransmitter receptor transport to plasma membrane), GO:0060291 (long-term synaptic potentiation), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:1902414 (protein localization to cell junction), GO:0099003 (vesicle-mediated transport in synapse), GO:1903539 (protein localization to postsynaptic membrane), GO:1990778 (protein localization to cell periphery), GO:1903540 (establishment of protein localization to postsynaptic membrane), GO:0035418 (protein localization to synapse), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030496 (midbody), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)