Protein: Heat shock protein STI1 (P15705)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May play a role in mediating the heat shock response of some HSP70 genes. It is required for optimal growth of yeast cells at both low and high temperature.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Sequence: MSLTADEYKQQGNAAFTAKDYDKAIELFTKAIEVSETPNHVLYSNRSACYTSLKKFSDALNDANECVKINPSWSKGYNRLGAAHLGLGDLDEAESNYKKALELDASNKAAKEGLDQVHRTQQARQAQPDLGLTQLFADPNLIENLKKNPKTSEMMKDPQLVAKLIGYKQNPQAIGQDLFTDPRLMTIMATLMGVDLNMDDINQSNSMPKEPETSKSTEQKKDAEPQSDSTTSKENSSKAPQKEESKESEPMEVDEDDSKIEADKEKAEGNKFYKARQFDEAIEHYNKAWELHKDITYLNNRAAAEYEKGEYETAISTLNDAVEQGREMRADYKVISKSFARIGNAYHKLGDLKKTIEYYQKSLTEHRTADILTKLRNAEKELKKAEAEAYVNPEKAEEARLEGKEYFTKSDWPNAVKAYTEMIKRAPEDARGYSNRAAALAKLMSFPEAIADCNKAIEKDPNFVRAYIRKATAQIAVKEYASALETLDAARTKDAEVNNGSSAREIDQLYYKASQQRFQPGTSNETPEETYQRAMKDPEVAAIMQDPVMQSILQQAQQNPAALQEHMKNPEVFKKIQTLIAAGIIRTGR
InterPro domains: - IPR041243: STI1/HOP, DP domain (domain) [138-580]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [2-518]
- IPR019734: Tetratricopeptide repeat (repeat) [5-497]
- IPR006636: Heat shock chaperonin-binding (domain) [138-576]
Interaction partners: - ATP-dependent molecular chaperone HSP82
- ATP-dependent molecular chaperone HSC82
- Hsp90 co-chaperone AHA1
- Heat shock protein SSA1
- Heat shock protein 104
- Peptidyl-prolyl cis-trans isomerase CPR6
- Peptidyl-prolyl cis-trans isomerase CYP7
- Heat shock protein homolog SSE1
- Protein SIS1
- Hsp90 co-chaperone Cdc37
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding), GO:0051087 (chaperone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006457 (protein folding), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:1901564 (organonitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0030163 (protein catabolic process), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0007031 (peroxisome organization), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0045324 (late endosome to vacuole transport), GO:0051603 (proteolysis involved in protein catabolic process), GO:0070972 (protein localization to endoplasmic reticulum), GO:0019941 (modification-dependent protein catabolic process), GO:0072665 (protein localization to vacuole), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0043162 (ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042579 (microbody), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)