Protein: Mannosyl-oligosaccharide glucosidase (EC 3.2.1.106) (Glucosidase I) (Q4WDB9)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004648, ECO:0000256|RuleBase:RU368089}.
Sequence: MHFPNLRFLLAPFLYNVVVSGWQASAADDLSVLATETAKANNDSLLWGPYKSNLYFGVRPRIANSLSAGLMWAKVDNYATAQASFRHTCEQNEGMAGYGWDEYDIRKGGRQTIHDTGNSLDLTIDFIKVPGGQHGGSWAARVRGIPREDGSPDQPTSIVFYATLEGLGNLGVATESGPIGYQGDVKLMGYTTELGDFSIDVTAGPETNEHPEHGHPSYEDKPLDRTLVSSSTIAPENLWQVKPIFFAQLKSEVNEMIQRFGQENPPPPAQVFTIKNAPGDGNIHLIQKVFKGAFEFDILFNSGSSPDPVTSDKLTEVISSASQSFSERFNKVLLPQSPFQTAEYSEFSKAMLSNLVGGIGFFHGDDIVDRSAAPEYDEENEGFWEETAEARARAQPVHEGPKDLFTCVPSRPFFPRGFLWDEGFHLIPVIDWDTDLALEIVKSWLNLMDEDGWIAREQILGAEARSKVPPEFTVQYPHYANPPTLFMVLEAFLDKLEASKGAYSQNSGGQEALDSLRMTYLQKPELGEAFIRSIYPLLKRHYFWYRTTQKGDIKSYDREAFSTKEAYRWRGRSVQHILTSGLDDYPRPQPPHPGELHVDLISWMGMMTRAMRRIAEFVGETEDVEEFRGYETAIERNIDDLHWDEEAQTYCDATIDEFEESVHVCHKGYISLFPFLTGMLGPDSPRLKAVLDLIRDPDELWSDYGIRSLSKKDEFYGTAENYWRSPIWMPINYLVVKNLYDIAMTSGPHQEQAREMYSSLRKNLVENVFRQWKETGFAWEQYNPETGKGQRTQHFTGWTSMVVKIMSMPDLPANKQIGHDEL
InterPro domains: - IPR012341: Six-hairpin glycosidase-like superfamily (homologous_superfamily) [337-810]
- IPR031631: Glycosyl hydrolase family 63, N-terminal (domain) [44-271]
- IPR004888: Glycoside hydrolase family 63 (family) [34-807]
- IPR031335: Glycosyl hydrolase family 63, C-terminal (domain) [310-808]
- IPR038518: Glycosyl hydrolase family 63, N-terminal domain superfamily (homologous_superfamily) [32-334]
- IPR008928: Six-hairpin glycosidase superfamily (homologous_superfamily) [335-808]
Interaction partners: - Oligosaccharyl transferase subunit
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3
- alpha-glucosidase
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2
- Oligosaccharyltransferase subunit ribophorin II, putative
- Calnexin homolog
- Geranylgeranyl diphosphate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044036 (cell wall macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0097502 (mannosylation), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0009100 (glycoprotein metabolic process), GO:0035268 (protein mannosylation), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0006996 (organelle organization), GO:0009101 (glycoprotein biosynthetic process), GO:0006493 (protein O-linked glycosylation), GO:0035269 (protein O-linked mannosylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)