Protein: Fatty acid metabolism regulator protein (P0A8V6)
Organism: Escherichia coli (strain K12)
Function: Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes
Subcellular location: Cytoplasm
Sequence: MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGLNILETLARLDHESVPQLIDNLLSVRTNISTIFIRTAFRQHPDKAQEVLATANEVADHADAFAELDYNIFRGLAFASGNPIYGLILNGMKGLYTRIGRHYFANPEARSLALGFYHKLSALCSEGAHDQVYETVRRYGHESGEIWHRMQKNLPGDLAIQGR
InterPro domains: - IPR028374: FadR, C-terminal domain (domain) [72-234]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [1-79]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [11-88]
- IPR000524: Transcription regulator HTH, GntR (domain) [6-74]
- IPR014178: Fatty acid response transcription factor FadR (family) [1-239]
- IPR008920: Transcription regulator FadR/GntR, C-terminal (homologous_superfamily) [79-239]
Interaction partners: - HTH-type transcriptional repressor FabR
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
- Acyl-coenzyme A dehydrogenase
- Long-chain-fatty-acid--CoA ligase
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- 3-oxoacyl-[acyl-carrier-protein] synthase 1
- HTH-type transcriptional regulator GntR
- HTH-type transcriptional regulator GntR
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0045834 (positive regulation of lipid metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0046890 (regulation of lipid biosynthetic process), GO:0045723 (positive regulation of fatty acid biosynthetic process), GO:0042304 (regulation of fatty acid biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019217 (regulation of fatty acid metabolic process), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)