Protein: Protein-methionine methyltransferase laeA (EC 2.1.1.-) (Secondary metabolism regulator laeA) (Velvet complex subunit laeA) (C8VQG9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Methyltransferase that performs automethylation at Met-207. No other methyl-accepting substrate has been identified yet. Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters. Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development. Within the velvet complex, controls light-dependent secondary metabolism. Involved in the defense response against Drosophila melanogaster larval grazing.
Subcellular location: Nucleus {ECO:0000269|PubMed:18556559}.
Sequence: MFEMGPVGTRLPAMTSPAHNHYSYHSPTSSDRGRSRQNSDAMDIQSITEREPATRYAVAGGPAPWNRNGSPSMSPMYSNNSERNQFHEENGRTYHGFRRGMYFLPCDEQEQDRLDIFHKLFTVARVSESLIYAPHPTNGRFLDLGCGTGIWAIEVANKYPDAFVAGVDLAPIQPPNHPKNCEFYAPFDFEAPWAMGEDSWDLIHLQMGCGSVMGWPNLYRRIFAHLRPGAWFEQVEIDFEPRCDDRSLDGTALRHWYDCLKQATAETMRPIAHSSRDTIKDLQDAGFTEIDHQIVGLPLNPWHQDEHERKVARWYNLAVSESIENLSLAPFSRVYRWPLERIQQLAADVKSEAFNKEIHAYNILHIYQARKPLR
InterPro domains: - IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [84-317]
Interaction partners: - Developmental and secondary metabolism regulator veA
- Velvet complex subunit B
- C2H2 type master regulator of conidiophore development brlA
- Spore development regulator vosA
- Sexual development regulator velC
- pH-response transcription factor pacC/RIM101
- Sterigmatocystin biosynthesis regulatory protein
- Conidiophore development regulator abaA
- Orotidine 5'-phosphate decarboxylase
- DNA-binding protein creA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0016274 (protein-arginine N-methyltransferase activity), GO:0008469 (histone arginine N-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016273 (arginine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0044550 (secondary metabolite biosynthetic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0043207 (response to external biotic stimulus), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0043455 (regulation of secondary metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:1900376 (regulation of secondary metabolite biosynthetic process), GO:1900378 (positive regulation of secondary metabolite biosynthetic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0033238 (regulation of amine metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0042762 (regulation of sulfur metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902932 (positive regulation of alcohol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)