Protein: E3 ubiquitin-protein ligase (D6WYJ4)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side
Sequence: MSNAPTSRRNGAQKIRLTILCARNLVRKDLFRLPDPFAKISVDGSGQCHSTEFVKNTLEPKWNSHYDLYIGRNDSITISVWNHRKVIKKQGSGFLGCVRIVNSHIQRLRDTGYQCLDLGKACPADSEPVKGQIIISLLSRDGPCSGTPLAVVGPQGELRGPTDRDSSPSNNDDLPPGWEERRTENGRPYYVNHITRSTQWIKPQSTNKTRRRSTHQNDNNNTNNENTIGGTQMGVQEILNNNTGETLTPSSSTSPVSPVVSPQKTTSTPQTTDNRNNFITLSPTSTSVIPAPNNISCNAPNGENTNVVSPQMGQGQGQRAIVRSERRQRSAEERRDGSSRRRSGRNNRNSGGTTAQGPVTQNSKLDLPPGYELRTTQQGQVYFYHIPTGVSTWHDPRIPKDLAPLSLALDHLGPLPPGWEMRQTASGRIYFVDHNNRTTQFTDPRLNTQILNNILRRASATSTTTPTTRTTPTTTTASTTSPSTSTTTVTTTTTTTAVPQNPAPLSPPPRTRIVEELPQSLLNDCDHLPKYRRDLVAKLKTLRAELTALQPQSGHCRLEVSRNEVFEESYRLIMKMRPKDMRKRLMVKFKGEEGLDYGGVAREWLHLLSREMLNPQYGLFQYSRDDHYTLQINPDSAVNPEHLSYFHFVGRILGIAVFHNHQLEGGFTLPFYKQLLNKPITLQDIEGVDPELHRSLTWMLENNIDGVLDTTFSVENNSFGIVKVHELKPSGATIPVTEDNKREYVKLYVNYRFMRGIEQQFLALQKGFTELIPPSLLRPFDERELELVISGIGSIDIADWRSHTRLKHCTPETPVVQWFWQVVESYSEEMRARLLQFVTGSSRVPLQGFKALQGSTGAAGPRLFTIHCIDCSPQNLPKAHTCFNRIDIPPYDSYQTLADKLTQAVEETCGFAVE
InterPro domains: - IPR000569: HECT domain (domain) [556-914]
- IPR036020: WW domain superfamily (homologous_superfamily) [169-447]
- IPR035983: HECT, E3 ligase catalytic domain (homologous_superfamily) [546-907]
- IPR001202: WW domain (domain) [172-446]
- IPR024928: E3 ubiquitin-protein ligase, SMURF1 type (family) [6-913]
- IPR000008: C2 domain (domain) [1-118]
- IPR050409: E3 ubiquitin-protein ligase (family) [164-911]
- IPR035892: C2 domain superfamily (homologous_superfamily) [10-140]
Interaction partners: - Mothers against decapentaplegic homolog
- Patched
- Receptor protein-tyrosine kinase
- TNF-receptor-associated factor 2
- E3 ubiquitin-protein ligase CBL
- E3 ubiquitin-protein ligase
- E3 ubiquitin-protein ligase NRDP1
- Ubiquitin-ribosomal protein eL40 fusion protein
- Uncharacterized protein
- receptor protein-tyrosine kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0009888 (tissue development), GO:0043170 (macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0009966 (regulation of signal transduction), GO:0036211 (protein modification process), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030514 (negative regulation of BMP signaling pathway), GO:0043412 (macromolecule modification), GO:0030510 (regulation of BMP signaling pathway), GO:0007398 (ectoderm development), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)