Protein: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Q92047)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L- asparaginyl residues in aging peptides and proteins
Subcellular location: Cytoplasm, cytosol
Sequence: MAWKSGGASHAELVNNLRKNGIIKSDRVYEVMLATDRSHFSRCNPYMDSPQSIGYQATISAPHMHAYALELLHDHLYEGAKALDVGSGSGILSVCFSRMVGPTGKVIGIDHIKELVEDSIANVKKDDPSLITSGRIKLIVGDGRMGFTEEAPYDAIHVGAAAPTVPQALLDQLKPGGRLILPVGPAGGNQMLEQYDKLEDGSTKMKPLMGVIYVPLTDKDKQWSRDEL
InterPro domains: - IPR000682: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (family) [2-223]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [2-227]
Interaction partners: - Transmembrane serine protease 15
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0051998 (protein carboxyl O-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008171 (O-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0010340 (carboxyl-O-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0043414 (macromolecule methylation), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0055123 (digestive system development), GO:0009100 (glycoprotein metabolic process), GO:0060537 (muscle tissue development), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0060429 (epithelium development), GO:0048565 (digestive tract development), GO:0030182 (neuron differentiation), GO:0061008 (hepaticobiliary system development), GO:0030855 (epithelial cell differentiation), GO:0008213 (protein alkylation), GO:0001889 (liver development), GO:0035315 (hair cell differentiation), GO:0001889 (liver development), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0046530 (photoreceptor cell differentiation), GO:0018193 (peptidyl-amino acid modification), GO:0030001 (metal ion transport), GO:0018205 (peptidyl-lysine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)