Protein: 1-phosphatidylinositol 3-phosphate 5-kinase (B2KTE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein
Sequence: MAADDKASSSSSVMDWSSEPPPSPTSPSHLTHFKPLTPEQDEPPLRSAYSSFVSLFRFNKEEGRPPSVTEKSQSASSSPQGPRRNWSSPSHSIHGSETHRKHPELLRRTSAASEGRRKSEAPLGSHDPRTAVQLRTALKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCNEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSSSIGEDLSALSDSPCSVCVLEPTEPRTPVGGRKASRNIFLEEDLAWQRKNSIGMRKNHQESQNSGLNSRLTVVQEDIGKSPARKRSASVTNLSLDRSGSSMVPAYESSVSPQNSRALPKTDHSEEERKILLDSFQLKDIWKKICHNTTGMEFQDHRYWLRTYPNCIVGKELVNWLLRNGTISTRAQAIAIGQALVDGRWLDCVTHHDQIFRDEYALYRPLQSTEFSETPSPDSDSVNSLEGHSEPSWFKDIKFDDSDTEQLADENDYVTPSSSSPSKRTSVSSFHSAVDSDSAASISLNMEQDNVNFHIKKQAKYPHVPPYPAEQKMEVLLSEDGGQHISISDAFIKESLFNRRVEEKAKEMLFTPLGWHHSSLDQLREENGEKKAMERLLSANHSHMMALLQQLLYSESLSLSWRDIIVPVVRQVVQTVRPDVRSCDDDMDIRQFVHIKKIPGGKKFDSAVVNGFVCTKNIAHKKMNSYIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPNLVLVEKTVSRIAQDMLLEHGIAIVINVKPQVLDRVSRMTQGDLVISMDQLLTKPRLGTCHKFYLHSFQLPNSEVKTLMFFEGCPPQLGCTIKLRGASEYELARVKEIIIFMVCVAYHSQLEISFLMDEFAMPPSLAESSSFPCLLESTTLREEDETSGERESQDNDESTLGDDNLTLVPGDDFETGFTGTIKAHSREPSTSESSHKDGESPRINKNASITSFSGGEEENIKTSTPLSSFSSTFPQPVTPPFLISDVKEMSQEVVKGSGEGEKNKYLESTLVHQDSTSSETSLPPTRLFRDPLQDDTGLFVTEHVASSDDRLKSISALFKQELKDIILCISPFITFREPFLLTPAGLRCPSRDYFPEQVYLSPLLNKDSKELDGRRKRQLLKESSPGSGSLTNGSVSHQRAIQILPCHKLTSARIAEQVGSSQQLARMLADYRAQGGRIRQREGTQFREAPPPKAPIKADSEEDKGAGVIDMTWSTKLDCLNPINHQRLCVLFSSSSAQSNNAPNPCVSPWIVTMEFYGKNDLTLGVFLERYCFRPSYQCPSMYCETPMVHHIRRFVHGKGCVQIVLKELDSPVPGYQHTILNYSWCRICKQVTPVVPLSNDSWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHKDYHQYFSYNQMVASFSYIPVRLLEICLPPPKIIIRNQGPSKSSLQQDLKDFSQKVAQVYLAIDDRLTSLKTDTFSKTREEKMEDMFAQKDMEESELRGWIEKLQVRLQTSVIDSSQQLQAVLESVVVKKQGLCETLQSWNNRLQELFQQEKGRKRLSVPPSPGRHRQPTTDESKTSALESSPRNPSPVVPNGDKEDRHLNTFPSSSGSSSLLQLPSPAEQPSDVITSGPSFPDQDSVSNPEDMFDGHLLGSNDSQVKEKSTMKTILANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEREPSSIIAFALSCKEYKTALEELTKTTAKTGGDDTSQTISAGESRVKNSPAKPSDNSMSQLSRSSVDADPLKEPESADKQKKQTGNPHIELQFSDANAKFYCRIYYAEEFHKMREEIMESTEDDFVRSLSHCVNWQARGGKSGAVFYATEDDRFILKQMPRLEVQSFLDFAPHYFTYITGAVHLKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDQGKESCEVVLLDENLLKLVHDNPLYIRSHCKAILRAAIHSDALFLSSHLIIDYSLLVGRDDSTDELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWSGLGLNC
InterPro domains: - IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [157-229]
- IPR000591: DEP domain (domain) [375-450]
- IPR002498: Phosphatidylinositol-4-phosphate 4/5-kinase, core (domain) [1747-2071]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [687-854]
- IPR027483: Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily (homologous_superfamily) [1927-2071]
- IPR000306: FYVE zinc finger (domain) [153-222]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [362-499]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [622-867]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [362-492]
- IPR037378: PIKfyve, DEP domain (domain) [367-448]
- IPR027484: Phosphatidylinositol-4-phosphate 5-kinase, N-terminal (homologous_superfamily) [1761-1925]
- IPR043548: 1-phosphatidylinositol-3phosphate-5-kinase (family) [1-2084]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [145-222]
- IPR044769: 1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain (domain) [1804-2070]
- IPR017455: Zinc finger, FYVE-related (domain) [161-221]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0016307 (phosphatidylinositol phosphate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007272 (ensheathment of neurons), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0050900 (leukocyte migration), GO:0033059 (cellular pigmentation), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0097529 (myeloid leukocyte migration), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0008366 (axon ensheathment), GO:0035556 (intracellular signal transduction), GO:0048731 (system development), GO:0019637 (organophosphate metabolic process), GO:0019538 (protein metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0051649 (establishment of localization in cell), GO:0051668 (localization within membrane), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0006793 (phosphorus metabolic process), GO:0006629 (lipid metabolic process), GO:0046907 (intracellular transport), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0016477 (cell migration), GO:0048753 (pigment granule organization), GO:0006935 (chemotaxis), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0071621 (granulocyte chemotaxis), GO:0097530 (granulocyte migration), GO:0071705 (nitrogen compound transport), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0042552 (myelination), GO:0006644 (phospholipid metabolic process), GO:0032438 (melanosome organization), GO:0071702 (organic substance transport), GO:0006796 (phosphate-containing compound metabolic process), GO:0090150 (establishment of protein localization to membrane), GO:0022607 (cellular component assembly), GO:0036211 (protein modification process), GO:0060326 (cell chemotaxis), GO:0032288 (myelin assembly), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0046486 (glycerolipid metabolic process), GO:0007399 (nervous system development), GO:0015031 (protein transport), GO:1903426 (regulation of reactive oxygen species biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0070925 (organelle assembly), GO:0006909 (phagocytosis), GO:0006612 (protein targeting to membrane), GO:0030593 (neutrophil chemotaxis), GO:0016050 (vesicle organization), GO:0006468 (protein phosphorylation), GO:1990266 (neutrophil migration), GO:0018193 (peptidyl-amino acid modification), GO:0016310 (phosphorylation), GO:0006650 (glycerophospholipid metabolic process), GO:0006605 (protein targeting), GO:0007033 (vacuole organization), GO:0006906 (vesicle fusion), GO:0048284 (organelle fusion), GO:0061025 (membrane fusion), GO:0090382 (phagosome maturation), GO:0001845 (phagolysosome assembly), GO:0090385 (phagosome-lysosome fusion), GO:0090174 (organelle membrane fusion), GO:0046488 (phosphatidylinositol metabolic process), GO:0018105 (peptidyl-serine phosphorylation), GO:0080171 (lytic vacuole organization), GO:0018209 (peptidyl-serine modification), GO:0046777 (protein autophosphorylation), GO:0007040 (lysosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0016020 (membrane)