Protein: Sialic acid-binding Ig-like lectin 12 (Siglec-12) (Myeloid inhibitory siglec) (MIS) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (Sialic acid-binding Ig-like lectin E) (Siglec-E) (mSiglec-E) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Q91Y57)
Organism: Mus musculus (Mouse)
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MLLLLLLLLLWGIKGVEGQNPQEVFTLNVERKVVVQEGLCVLVPCNFSYLKKRLTDWTDSDPVHGFWYREGTDRRKDSIVATNNPIRKAVKETRNRFFLLGDPWRNDCSLNIREIRKKDAGLYFFRLERGKTKYNYMWDKMTLVVTALTNTPQILLPETLEAGHPSNLTCSVPWDCGWTAPPIFSWTGTSVSFLSTNTTGSSVLTITPQPQDHGTNLTCQVTLPGTNVSTRMTIRLNVSYAPKNLTVTIYQGADSVSTILKNGSSLPISEGQSLRLICSTDSYPPANLSWSWDNLTLCPSKLSKPGLLELFPVHLKHGGVYTCQAQHALGSQHISLSLSPQSSATLSEMMMGTFVGSGVTALLFLSVCILLLAVRSYRRKPARPAVVAPHPDALKVSVSQNPLVESQADDSSEPLPSILEAAPSSTEEEIHYATLSFHEMKPMNLWGQQDTTTEYSEIKFPQRTAWP
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [29-145]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [30-343]
- IPR007110: Immunoglobulin-like domain (domain) [21-339]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [17-347]
- IPR003598: Immunoglobulin subtype 2 (domain) [269-330]
- IPR051036: Sialic acid-binding Ig-like lectin (family) [1-459]
- IPR003599: Immunoglobulin domain subtype (domain) [30-339]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [321-327]
Interaction partners: - Mucin-1
- Amine oxidase [copper-containing] 3
- Tyrosine-protein phosphatase non-receptor type 11
- Toll-like receptor 4
- Toll-like receptor 2
- Elongation factor 1-alpha 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002683 (negative regulation of immune system process), GO:0048585 (negative regulation of response to stimulus), GO:0050777 (negative regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0002697 (regulation of immune effector process), GO:0030449 (regulation of complement activation), GO:0045916 (negative regulation of complement activation), GO:0002920 (regulation of humoral immune response), GO:0002921 (negative regulation of humoral immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)