Protein: Acetyl-CoA hydrolase (P83773)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Presumably involved in regulating the intracellular acetyl- CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation
Subcellular location: Cytoplasm
Sequence: MSAILKQRVRYAPYLKKLRTGEQCIDLFKHGQYLGWSGFTGVGAPKVIPTTLVDHVEKNNLQGKLGFHLFVGASAGPEESRWAENNMILTRAPHQVGKPIAAAINDGRTQFFDKHLSMFPQDLTYGFYTKDKPNGSNLDYTIIEATAITEDGSIVPGPAVGASPEMISVSDKIIIEVNTKTPSFEGIHDIDMPVNPPFRQPYPHTSADFKIGKTAIPVDPEKVVAIVESTSGDKVPPNTPSDEQSRGIANHLIEFLEHEVKQGRLPANLHPLQSGIGNIANAVVEGLASSNFKNLTVWTEVLQDSFLDFFESGSLDYATATSIRLTNDGFKKFYDNWDTYSKKLCLRSQVVSNSPEIIRRLGVIAMNTPVEVDIYGHANSTNVMGSRMLNGLGGSADFLRNAKLSIMHTPSARPSKVDPTGLSCIVPMASHVDQTEHDLDVVVTEQGLADLRGLAPKARAKVIIDKCSHPDYKPQLQEYYDRSVFYATKKKTLHEPHILRDVFKMHLNFQENGTMKLDSWDQKF
InterPro domains: - IPR003702: Acetyl-CoA hydrolase/transferase, N-terminal (domain) [10-228]
- IPR038460: Acetyl-CoA hydrolase/transferase, C-terminal domain superfamily (homologous_superfamily) [350-496]
- IPR026888: Acetyl-CoA hydrolase/transferase, C-terminal domain (domain) [329-479]
- IPR037171: NagB/RpiA transferase-like (homologous_superfamily) [6-516]
- IPR046433: Acetyl-CoA hydrolase/transferase (family) [2-520]
Interaction partners: - Acetyl-coenzyme A synthetase 2
- Malate synthase
- Acetyl-coenzyme A synthetase
- Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
- Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial
- Acetyl-CoA acetyltransferase
- Aldehyde dehydrogenase (NAD(P)(+))
- Acetyltransferase component of pyruvate dehydrogenase complex
- Acetyl-CoA carboxylase
- Aldehyde dehydrogenase domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0008410 (CoA-transferase activity), GO:0016790 (thiolester hydrolase activity), GO:0016289 (CoA hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0019541 (propionate metabolic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0019679 (propionate metabolic process, methylcitrate cycle), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046459 (short-chain fatty acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0030445 (yeast-form cell wall)