Protein: Glial fibrillary acidic protein (GFAP) (P47819)
Organism: Rattus norvegicus (Rat)
Function: GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P14136}. Note=Associated with intermediate filaments. {ECO:0000250|UniProtKB:P14136}.
Sequence: MERRRITSARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPLPARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTTNSARLEVERDNLTQDLGTLRQKLQDETNLRLEAENNLAVYRQEADEATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
InterPro domains: - IPR050405: Intermediate filament structural protein (family) [9-423]
- IPR006821: Intermediate filament head, DNA-binding domain (domain) [7-64]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [361-369]
- IPR039008: Intermediate filament, rod domain (domain) [66-375]
Interaction partners: - Elongation factor 1-alpha 1
- RNA binding protein fox-1 homolog 3
- Allograft inflammatory factor 1
- Oligodendrocyte transcription factor 2
- Myelin basic protein
- Synaptophysin
- Protein S100-B
- Neuronal migration protein doublecortin
- Macrosialin
- Peroxidasin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019902 (phosphatase binding), GO:0019901 (protein kinase binding), GO:0019903 (protein phosphatase binding), GO:0051721 (protein phosphatase 2A binding), GO:1990782 (protein tyrosine kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009991 (response to extracellular stimulus), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0007417 (central nervous system development), GO:0014070 (response to organic cyclic compound), GO:0030182 (neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0043209 (myelin sheath), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0030424 (axon), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)