Protein: Cyclin-dependent kinase B1-1 (CDKB1;1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog B) (P25859)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May control G2/M (mitosis) phase progression. Plays a role in regulating seedling growth in darkness via regulation of hypocotyl cell elongation and cotyledon cell development. Plays a role in stomatal development. Required to suppress endoreduplication. Together with CDKB1-2, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage.
Subcellular location: Nucleus {ECO:0000269|PubMed:20675570}.
Sequence: MEKYEKLEKVGEGTYGKVYKAMEKGTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSTSIYVVRLLCVEHVHQPSTKSQSTKSNLYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLMFQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVPLKSYTHEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLGTPTEQQWPGVSTLRDWHVYPKWEPQDLTLAVPSLSPQGVDLLTKMLKYNPAERISAKTALDHPYFDSLDKSQF
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1-304]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [138-150]
- IPR050108: Cyclin-dependent kinase (family) [2-301]
- IPR017441: Protein kinase, ATP binding site (binding_site) [10-33]
- IPR000719: Protein kinase domain (domain) [4-301]
Interaction partners: - Cyclin-A2-3
- Cyclin-dependent kinases regulatory subunit 1
- Retinoblastoma-related protein 1
- Cyclin-dependent kinases regulatory subunit 2
- Cyclin-B1-2
- Cyclin-D4-1
- Cyclin-A2-1
- Cyclin-A1-1
- Cyclin-A2-4
- Cyclin-A2-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0030332 (cyclin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0009791 (post-embryonic development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010374 (stomatal complex development), GO:0009888 (tissue development), GO:0010564 (regulation of cell cycle process), GO:0030154 (cell differentiation), GO:0010440 (stomatal lineage progression), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0090558 (plant epidermis development), GO:0032875 (regulation of DNA endoreduplication), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0090627 (plant epidermal cell differentiation), GO:0051052 (regulation of DNA metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:0006275 (regulation of DNA replication), GO:0090329 (regulation of DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)