Protein: Host cell factor 2 (HCF-2) (C2 factor) (Q5RKG2)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9Y5Z7}. Nucleus {ECO:0000250|UniProtKB:Q9Y5Z7}.
Sequence: MAAPSLLNWRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTVTNQWFLPAVRGDIPPGCAAHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPQPPPSGLPPCPRLGHSFSLYGNKCYLFAGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSVPATKGTVPSPRESHTAVIYCKRDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTENSPHDCEWRCTSSFSYLNLDTAEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVPTVEGYLLQLNTDLTHQAASPDASAAPNTLGGRTDPHRQGSNSILHNSVSDPANCTKPEHTAVAARGMSLKSKPDSRAADSSVALHSPLAPNTSNNNSCMADMLWKSEVDEICALPATKISRVEAHAAATPFSKETPSNPVAILKAEQWCDVGIFKNNTALVSQFYLLPKGKQSMSKVGNADVPDYSLLKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKTCIPGFPGAPSTVRISKNVEGIHLSWEPPTSPSGNILEYSAYLAIRTAQVQDNPSQLVFMRIYCGLKTSCIVTAGQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQGNSKKAPLS
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [356-712]
- IPR003961: Fibronectin type III (domain) [357-709]
- IPR015915: Kelch-type beta-propeller (homologous_superfamily) [2-356]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [523-722]
- IPR043536: Host cell factor (family) [5-432]
Interaction partners: - Host cell factor 1
- Set1/Ash2 histone methyltransferase complex subunit ASH2
- Retinoblastoma-binding protein 5
- WD repeat-containing protein 5
- [histone H3]-lysine
- Histone-lysine N-methyltransferase 2B
- [histone H3]-lysine
- Histone-lysine N-methyltransferase
- CXXC-type zinc finger protein 1
- UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0044877 (protein-containing complex binding), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0042802 (identical protein binding), GO:0003713 (transcription coactivator activity), GO:0140297 (DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044092 (negative regulation of molecular function), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0019867 (outer membrane), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005640 (nuclear outer membrane), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031968 (organelle outer membrane), GO:0005634 (nucleus)