Protein: Neuregulin 1 (Pro-neuregulin-1, membrane-bound isoform isoform IIa) (A0A0R4IDP7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MAILPGRSSSLTVSVLYGAAVCLSLWTRVVRCGSFACSPPGASVQELARRSGVVFEGKLQEEERAERNWTETPMNASRQVRVRVQQVWQLKAGGLIKDSVVSLVWFEGGRCFQLNTGIRYMFFIEPTNDTSVFTAVFPPVETKRTVRKDVSQVLCQDCAEPKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTCEAVNSLGKTNTTANLFIINTATSTTPSAKTSSHVTPCNESEKEYCVNHGKCFTLEVTPGNIRRLCRCPPGFTGNRCQNRDPVRVVDHKQAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRERNAAAKGPQHPHPPPENLQLVNHYMPTNPVPAHMTDKEAETSLSTNEFTSPTHPSTAITHSSSQCWSNGKAESVVSDSHAVLMKPSAENCQHGTPSHRGRLNATGGVHQLNDYLKNSREAQGSNRDSPYSERYVSAMTTPTRLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTSPSGEEERPLLFRTPPILRDKSASTQGRKSGHNLRNSAHYNHGLDIPSPPPSPLHIEEEIDCLEQYKSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSSSESETEDERVGEDTPFLGLQNPLAAGSLVLDGLEGSRTNPALHLSPQHELQNRLTAVMANQDPIAV
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [164-257]
- IPR013098: Immunoglobulin I-set (domain) [165-255]
- IPR007110: Immunoglobulin-like domain (domain) [161-254]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [147-255]
- IPR003598: Immunoglobulin subtype 2 (domain) [172-245]
- IPR002154: Neuregulin, C-terminal (domain) [360-707]
- IPR003599: Immunoglobulin domain subtype (domain) [166-256]
- IPR000742: EGF-like domain (domain) [271-315]
- IPR057909: Neuregulin 2, N-terminal domain (domain) [47-142]
- IPR040180: Neuregulin (family) [32-725]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0021575 (hindbrain morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0001708 (cell fate specification), GO:0021695 (cerebellar cortex development), GO:0003205 (cardiac chamber development), GO:0022037 (metencephalon development), GO:0021696 (cerebellar cortex morphogenesis), GO:0045165 (cell fate commitment), GO:0021549 (cerebellum development), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0021697 (cerebellar cortex formation), GO:0009888 (tissue development), GO:0060322 (head development), GO:0003206 (cardiac chamber morphogenesis), GO:0021587 (cerebellum morphogenesis), GO:0042246 (tissue regeneration), GO:0061383 (trabecula morphogenesis), GO:0031099 (regeneration), GO:0016477 (cell migration), GO:0021781 (glial cell fate commitment), GO:0055006 (cardiac cell development), GO:0048864 (stem cell development), GO:0021533 (cell differentiation in hindbrain), GO:0060415 (muscle tissue morphogenesis), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0048644 (muscle organ morphogenesis), GO:0003231 (cardiac ventricle development), GO:0060485 (mesenchyme development), GO:0048666 (neuron development), GO:0001667 (ameboidal-type cell migration), GO:0031101 (fin regeneration), GO:0003208 (cardiac ventricle morphogenesis), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0007399 (nervous system development), GO:0003007 (heart morphogenesis), GO:0061384 (heart trabecula morphogenesis), GO:0007422 (peripheral nervous system development), GO:0072359 (circulatory system development), GO:0008347 (glial cell migration), GO:0060537 (muscle tissue development), GO:0048484 (enteric nervous system development), GO:0007417 (central nervous system development), GO:0007517 (muscle organ development), GO:0048762 (mesenchymal cell differentiation), GO:0035051 (cardiocyte differentiation), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0048483 (autonomic nervous system development), GO:0014033 (neural crest cell differentiation), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0048709 (oligodendrocyte differentiation), GO:0055008 (cardiac muscle tissue morphogenesis), GO:0021953 (central nervous system neuron differentiation), GO:0014044 (Schwann cell development), GO:0090497 (mesenchymal cell migration), GO:0042063 (gliogenesis), GO:0003222 (ventricular trabecula myocardium morphogenesis), GO:0048699 (generation of neurons), GO:0014037 (Schwann cell differentiation), GO:0014032 (neural crest cell development), GO:0055010 (ventricular cardiac muscle tissue morphogenesis), GO:0003229 (ventricular cardiac muscle tissue development), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)