Protein: Protein REDUCED CHLOROPLAST COVERAGE 3 (F4HZK4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as the scaffold of a protein complex, which sequesters key factors that are required for the G2 to M transition in meristematic tissues (By similarity). Together with REC2, REC3 and FMT/CLU, contributes to the establishment of the cellular volume devoted to the chloroplast compartment.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:F4HS99, ECO:0000255|PROSITE-ProRule:PRU00768}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:F4HS99}.
Sequence: MAPRSSKGKSNNKGKGGDKKKRDDKLLAPSLVEITVTTPYETQVILKGVSTDKIIDVRRLLASHVETCHFTNYSLSHKVKGHKLNDNIQVLSLKPCFLRMIPEEYLEESQALTQVRRVIDIVACTTRFFSKSPNKSIVAGNANPTPAPDGLDMVAIHTTPKLSQFYEFFSIHHLSPPILHLKKVDGEEAGEKRDGDYFGLKVKICNGKVIHVIASVKGFFAVGKQLSHCHSIVDLLQNVSNAFAKAYESLMKAFTDRNKFGNLPFGLRSNTWLVPSPVSESASPLPTEDEHWGGNGGGQGRNGEYDHRPWAAEFSVLATLPCKTEEERVIRDKKAFLLHSQFIDTSVQRAVRAICNVMDTNQQTSGTTDLPAGSILLEDHVGDLSIVVKRDIASLDSKPEATFQNDAFVLSSEELAERNLLKGITADESVIVHDTPALGKVIVRQCGYTAVVNVKGQTQKAMSDFRDILIDDLPDGGANALNLNSLRVEFHRPHSVGTSVENQPTQLDWDDLESYRCIIQELVKINLTKLEETRVSSVRPIRWELGSTWVQHLQKKETDVCGKPATNDETELSVKGLGKQFKDLKSKSKKSENISAVNEKDTRLHELNEEDDLGQKSIDGLFTELKELLSEEAFSRLKETGTGLHLKSKEELTNMAYGYYDEIALPRLVADFGSLELSPVDGRTLTDFMHIRGLQMRSLGHVAKLAEKLPHIQSLCIHEMITRAFKHLLRAVIASVNNMAELPVAVAASLNFMLGRRELEGCDRIPGEEYCLRLQWLQKFLSRKFGWIQKDEFHHLKKFSILRGLCQKVGLELVSRDFDFDSPNPFMSSDIIGLVPVCKHVLCISSDGRTLLESSKLALDKGKLDDAVSYGTKALVKMIAVCGPYHRNTACAYSLLAVVLYHTGDFNQATIYQQKALDINERELGLDHPDTMKSYGDLSVFYYRLQHFELALKYVNRALFLLHFTCGLSHPNTAATYINVAMMEKEVGNDHLALRYLHEALKSNKRLLGADHIQTAASYHAIAVALSFMEAHSLSVQHEQTTLQILTAKLGADDLRTQDAAAWLEYFESRAIEQQEAGRNGIPKPDASIASKGHLSVSDLLDYISSDPDTKGNVAHRKHRRARILQVNDKVASADDDAHRVASQIDIVTWNNVAEADVTKSRSEVNDPDTVVDKTNIETGDIVVHRLNVDRQTVEESTLDEGWQEAYSKGRSGNGAGRKSRQRQPDLMKKRMLLNKHHNRNQDVQQQNIYSPLQKTSKGPSLSKSSPRRALKNAEIDVSTNTTKPQLKASGAAAVTSTTLASKSLSYKEVALAPPGTVLKPMLEKLELNLERTETQIYRTSSASSGEESKSDTVMLDLPIEGTELHCEKQESQESAESVENLTSESEGDLGSYRGKKTSDISRTKLSASAEPYNPGGFLVIDLQSSAATIGSYPIMVADPISWAVVSCGIHSPPYYSAIHSNGVGTPRSMNPDAPEFVPRRSLQNSSQHAGEDASVSVDSSSCLKAEKDAVDLKKRELASFIVKSSQKEVPAALSKTSPEAESGGTSEKDSAVTEIVYSREEENGANANETNGGEGFVIVAKKRRRKNKVRLTNVAAGLYHQPSSVCA
InterPro domains: - IPR027523: CLU domain containing protein (family) [1-1371]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [846-1084]
- IPR025697: CLU domain (domain) [288-564]
- IPR019734: Tetratricopeptide repeat (repeat) [890-1007]
- IPR033646: CLU central domain (domain) [677-820]
Interaction partners: - CASC3/Barentsz eIF4AIII binding protein
- SEED MATURATION PROTEIN 1
- Pentatricopeptide repeat-containing protein At1g30610, chloroplastic
- Eukaryotic initiation factor 4A-III homolog
- Ethylene-responsive transcription factor ERF022
- Protein SUPPRESSOR OF NIM1 1
- Peptidyl-prolyl cis-trans isomerase CYP63
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0051640 (organelle localization), GO:0050794 (regulation of cellular process), GO:0051644 (plastid localization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0010906 (regulation of glucose metabolic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0010675 (regulation of cellular carbohydrate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)