wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: C2H2-type zinc finger family protein (Putative C2H2-type zinc finger protein) (O81013)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MKRTRDLYGDESSSSESEEFHREKIRVKVKLPEERSEDEDESPQPQRKHFCVICEKQFSSGKAYGGHVRIHSIEYNNKGKMKKMKKMKLKKKKKRKIGLVKKEKEKEIDLARTDVEGKIRCCLCGKEFQTMHSLFGHMRRHPDRTWKGIRPPPPSEKFNLSYLDDDVDDEDEDDDDVMSRSMMMSDVPEDVQGAACILMMLSYASRNYWAGIEESPKSEVRSSSFYKDDEGKDKVLGDSRMDEKKGLIVDMKIKMEMEVKVNSPRDEAKRSLGFDLNQPPYHEDHP
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [49-143]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [47-141]
Interaction partners: - C2H2 and C2HC zinc fingers superfamily protein
- HAT family dimerization domain-containing protein
- Ac-like transposase
- C2H2-type zinc finger family protein
- Zinc finger protein ZAT8
- Zinc finger protein ZAT5
- Zinc finger protein ZAT18
- Zinc finger protein ZAT11
- Zinc finger protein AZF3
- Zinc finger protein ZAT7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Small ubiquitin-related modifier 3-like (SUMO-3-A) (Q6NV25)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
Sequence: MSEDKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSIRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGSC
InterPro domains: - IPR022617: Rad60/SUMO-like domain (domain) [17-85]
- IPR000626: Ubiquitin-like domain (domain) [15-92]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [3-92]
Interaction partners: - SUMO-conjugating enzyme UBC9-A
- Si:ch1073-55a19.2.
- SUMO-conjugating enzyme UBC9-B
- SUMO-activating enzyme subunit 1
- SUMO-activating enzyme subunit 2
- FinTRIM family, member 52, pseudogene.
- Proliferating cell nuclear antigen
- RING finger protein 4
- Ubiquitin-like protein NEDD8
- NEDD8 ubiquitin-like modifier, like.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0019789 (SUMO transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Fig1p (Q59WR6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MNLPLKFTIVFTIIIQFITAALLSFLLLGCIDTSSNYSNVYLLSYKFNQSSPLYDYLSTSSNSSITTTTTTNNNSTAIDELSVKVGYMGVCLSSSSKDISCTTYTGLDSFPKFSISMLSGDLDLVQLAQSFSNICHPRILLATIILTLIGLIILCYCVIPIVPGKSIMKKLNAGLSFILLLLWGLGSMLQHQAVVTSVEMMQQSSFQLLIGTRGGRAEAMTWTAFSFILMMFLSACLSWWMEIRMSKLNGKSSQHQQQPSVDTKI
InterPro domains: - IPR033481: Cell fusion protein Dni1/Fig1 (family) [2-255]
- IPR016509: Factor-induced gene 1 protein (family) [1-257]
Interaction partners: - Fus1p
- Alpha-factor pheromone receptor
- Kar4p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0030447 (filamentous growth), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0016043 (cellular component organization), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: General regulatory factor 8 (F4KHY7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MATTLSRDQYVYMAKLAEQAERYEEMVQFMEQLVSGATPAGELTVEERNLLSVAYKNVIGSLRAAWRIVSSIEQKEESRKNEEHVSLVKDYRSKVETELSSICSGILRLLDSHLIPSATASESKVFYLKMKGDYHRYLAEFKSGDERKTAAEDTMIAYKAAQDVAVADLAPTHPIRLGLALNFSVFYYEILNSSEKACSMAKQAFEEAIAELDTLGEESYKDSTLIMQLLRDNLTLWTSDMQVCPILYFHIQLHHQKLAY
InterPro domains: - IPR023409: 14-3-3 protein, conserved site (conserved_site) [48-239]
- IPR036815: 14-3-3 domain superfamily (homologous_superfamily) [1-245]
- IPR000308: 14-3-3 protein (family) [1-245]
- IPR023410: 14-3-3 domain (domain) [7-251]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051117 (ATPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050794 (regulation of cellular process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009755 (hormone-mediated signaling pathway), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0009741 (response to brassinosteroid), GO:0032870 (cellular response to hormone stimulus), GO:0014070 (response to organic cyclic compound), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:1901701 (cellular response to oxygen-containing compound), GO:0043401 (steroid hormone mediated signaling pathway), GO:0071367 (cellular response to brassinosteroid stimulus), GO:0071383 (cellular response to steroid hormone stimulus), GO:0071396 (cellular response to lipid), GO:0071407 (cellular response to organic cyclic compound), GO:0009742 (brassinosteroid mediated signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: HTH LytTR-type domain-containing protein (A0A0H2URK9)
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Function: Not known
Sequence: MMKLRIEIDGNLEETEIVIKTPTLTDEIADLQRLLQESKAPRLTFYKGTGEYYLDLSEILFFETEGSKIYAHNQKEAYEVRLKLYELESILPRYFNRVSKSTIANIRQIYSVDKSFSGTGTISFYQTHKEVHVSRHYQSLLKENLRNMR
InterPro domains: - IPR007492: LytTR DNA-binding domain (domain) [43-147]
- IPR046947: Transcriptional regulatory protein LytR-like (family) [35-146]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Small ribosomal subunit protein eS7x (40S ribosomal protein S7-3) (Q8LD03)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MFSAQNKIKKDKNAEPTECEEQVAQALFDLENTNQELKSELKDLYINQAVHMDISGNRKAVVIYVPFRLRKAFRKIHPRLVRELEKKFSGKDVIFVTTRRIMRPPKKGAAVQRPRNRTLTSVHEAMLEDVAFPAEIVGKRTRYRLDGSKIMKVFLDAKEKNNTEYKLETMVGVYRKLTGKDVVFEYPVEA
InterPro domains: - IPR047861: Small ribosomal subunit protein eS7, conserved site (conserved_site) [79-92]
- IPR000554: Small ribosomal subunit protein eS7 (family) [1-189]
Interaction partners: - Small ribosomal subunit protein uS9x
- Small ribosomal subunit protein eS10x
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Small ribosomal subunit protein uS15z
- Small ribosomal subunit protein eS30z/eS30y/eS30x
- Small ribosomal subunit protein eS24z
- Small ribosomal subunit protein eS6z
- Small ribosomal subunit protein eS24y
- Small ribosomal subunit protein eS1y
- Small ribosomal subunit protein eS1z
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0003735 (structural constituent of ribosome), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009561 (megagametogenesis), GO:0016043 (cellular component organization), GO:0009559 (embryo sac central cell differentiation), GO:0048229 (gametophyte development), GO:0030154 (cell differentiation), GO:0010197 (polar nucleus fusion), GO:0006996 (organelle organization), GO:0009553 (embryo sac development), GO:0048284 (organelle fusion), GO:0006997 (nucleus organization), GO:0000741 (karyogamy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0022627 (cytosolic small ribosomal subunit), GO:0009507 (chloroplast), GO:0015935 (small ribosomal subunit), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005840 (ribosome)
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A0R4IIN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MPSSVRAGSLKDPEVAELFYKEDPEKLFTDLREIGHGSFGAVYFAHDIRTNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPNTVEYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLVYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSNHWSDYFRNFVDSCLQKISQDRPTSDVLLKHHFLCRERPVTVVMDLIARTKDAVRELDNLQYRKMKKILFQETHNGPATEGTEEEEDVEQYMLRTGTVNSMESSHSLPSMSISASSQSSSVNSLADGSDDSGEMAMMQEGEHTVTSNSSVLHKALNHDNIYDDPYQPEMDSQQQQQQGPSGGRRRRGRDHFATIRTASLVTRQIQEHEQGSALREQMSGYKRMRRQHQKQLMALENKLKAEMDEHQLRLDKELETQRNNFGSEADKLSKKHQAILEKETKGAIAEEKKFQQHILGQQKKELTSLLESQKRHYRQRKEQLKEELNENQSTPKREKQEWLVQQKECLQQVQAEEEAGLLRRQRQYYELQGRQYKRKMLLSRHNLEQDLLREDLNKKQTLKDLECAMLLRHHESTQELEFRQLALVQRTRADLIRTQHQTELTNQMEYNKRREQELRQKHAVEVRQQPKSLRSKELQIKRQFQDTCKIQTRQYKALRNHLLENTPKSDHKAVLKRLKDEQTRKLAILAEQYDHSINDMLSTQALRLDETQEAEYQVLRMQLQQELELLNAYQSKIKMHTDTQHEREGKDLEQRVSIRRALLEQRIEEEMLALQNERSERIRSLLERQASEIEAFDSESLRLGFSSLALTGIPSEAHPKQGYPSSQTPRPSGHWSHGGGPHPHPRRGPSRAESTSSSSVSHALGLARDGPLHHSSRSSSSSSSSSSSSHHNRHHLPQHYHHQSTPQLYRDREREREREREKEKEWGGGGSRADHPHLFPHHLPSRSSSQSLALLPPPPPAPMLSASSAQSSGSQGVYGGGGGGLVVRGPSLMALRNSPQPLRRTASGGPGAPAGADGVLSRSTSVTSHISNGSHLSYS
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [27-296]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [147-159]
- IPR051234: TAO Serine/Threonine-Protein Kinase (family) [1-1120]
- IPR017441: Protein kinase, ATP binding site (binding_site) [34-58]
- IPR000719: Protein kinase domain (domain) [28-281]
Interaction partners: - Dual specificity mitogen-activated protein kinase kinase 6
- HIRA-interacting protein 3.
- PAXIP1-associated glutamate-rich protein 1
- Aspartate beta-hydroxylase domain-containing protein 2
- Seizure-related 6 homolog
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
- Double C2-like domain-containing protein alpha isoform X2
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
- TLC domain-containing 3Ba.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005938 (cell cortex)
Protein: S-methyl-5'-thioadenosine phosphorylase (EC 2.4.2.28) (5'-methylthioadenosine phosphorylase) (MTA phosphorylase) (MTAP) (MTAPase) (A0A384ME80)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03155}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03155}.
Sequence: MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
InterPro domains: - IPR000845: Nucleoside phosphorylase domain (domain) [11-255]
- IPR018099: Purine phosphorylase, family 2, conserved site (conserved_site) [58-98]
- IPR035994: Nucleoside phosphorylase superfamily (homologous_superfamily) [9-283]
- IPR010044: Methylthioadenosine phosphorylase (MTAP) (family) [3-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0004645 (1,4-alpha-oligoglucan phosphorylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0031981 (nuclear lumen), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)
Protein: Protein TOS4 (Target of SBF protein 4) (Q06266)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in pheromone response, polarized growth and transcription.
Subcellular location: Nucleus {ECO:0000269|PubMed:15282802}.
Sequence: MSSQFPSSPYRTVDPYSPPNYKQQPNCPSSNYEKAGKTASESIGNFGKGDYPTPFPSSSIGRVSSPVRSNKVDAIPSSPAFPGQLAETSPKFSSKLSSPSRHTRVINAELDPSKISTITVGRNSSQCDVALCKNKFISRVHASITYLPQTNEVKIHCFSMNGLIVTYRKQFDCYQLKDTMNNNNRAYRLVPRFSNEKCVKEIQDEGGFINFTLEEGDTVYMTYYKGIMLDFRQVLLRISLKEKNSSSEPLRFEKKAEFESESETKHMGSIRKHPLIFTDTSMDRPKKILKDSNKISIGSDSGVAERMLNHFLNSKSSPLSSVSSVDHEEQTLRQDSLSSDKNPMTMKKPKLNKRVLPSKPKKSVKENLDELSRRNIDVMHLQHILTNHLAFANVQQTPLFQLQQVNSQISELSRDELRSILSDAKCVGVIYRHGKDAAGKPLDEEYFYDLENDDDYERRNLVSSLKGGRTGLRSCRRTHKQYFWKKPAK
InterPro domains: - IPR000253: Forkhead-associated (FHA) domain (domain) [117-177]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [117-177]
Interaction partners: - Probable histone deacetylase HOS2
- Histone deacetylase RPD3
- Transcriptional regulatory protein ASH1
- SET domain-containing protein 3
- Cyclin-dependent kinase 1
- Transcriptional regulatory protein DOT6
- Transcriptional regulatory protein UME1
- Transcriptional regulatory protein UME6
- Transcriptional regulatory protein SIN3
- Transcriptional regulatory protein PHO23
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)