Protein: Actin-binding protein WASF3 (Protein WAVE-3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3) (Q8VHI6)
Organism: Mus musculus (Mouse)
Function: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Sequence: MPLVKRNIEPRHLCRGALPEGVTSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTIQDQQVVSKNSIPNPVADIYNQSDKPPPLSILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRVDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVHHGASSEGSLSPDTRSHTSDVTDYSYPATPNHALQAQPATPSYTAGDAPLHGTTNQGAEHEYRPSSASARHMALNRPQQPPPPPPPQAPEGSQASTSVAPADYGMLPAQIIEYYSPSGPPPPPPPPMIPSAQTAFVSPLQMPTQPPFPASAVSTYPTPPHQPSTGLLATAPPPPGPPPPPPGPPGPSSLSSSPMHGPPVAEAKRPEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSDDDSEFDENDWSD
InterPro domains: - IPR028288: SCAR/WAVE family (family) [1-249]
- IPR003124: WH2 domain (domain) [437-462]
Interaction partners: - Nck-associated protein 1
- Cytoplasmic FMR1-interacting protein 1
- Abl interactor 1
- Nck-associated protein 1-like
- Cytoplasmic FMR1-interacting protein 2
- Abl interactor 2
- Protein BRICK1
- ABI gene family member 3
- Actin-binding protein WASF2
- Actin, cytoplasmic 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0048584 (positive regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0030029 (actin filament-based process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0030048 (actin filament-based movement), GO:0044085 (cellular component biogenesis), GO:0035556 (intracellular signal transduction), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:0030036 (actin cytoskeleton organization), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0046907 (intracellular transport), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0010647 (positive regulation of cell communication), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0030030 (cell projection organization), GO:0098751 (bone cell development), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0007264 (small GTPase mediated signal transduction), GO:0051650 (establishment of vesicle localization), GO:0001667 (ameboidal-type cell migration), GO:0022607 (cellular component assembly), GO:0045880 (positive regulation of smoothened signaling pathway), GO:0060348 (bone development), GO:0048514 (blood vessel morphogenesis), GO:0001501 (skeletal system development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0006915 (apoptotic process), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0008104 (protein localization), GO:0007264 (small GTPase mediated signal transduction), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0007507 (heart development), GO:0060840 (artery development), GO:0007015 (actin filament organization), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0035904 (aorta development), GO:0048745 (smooth muscle tissue development), GO:0001654 (eye development), GO:0030031 (cell projection assembly), GO:0010592 (positive regulation of lamellipodium assembly), GO:0048844 (artery morphogenesis), GO:0044782 (cilium organization), GO:0035909 (aorta morphogenesis), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0048593 (camera-type eye morphogenesis), GO:0016601 (Rac protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0031975 (envelope), GO:0098794 (postsynapse), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0019867 (outer membrane), GO:0030027 (lamellipodium), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031968 (organelle outer membrane), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)