Protein: Sex-determining transformer protein 1 (Cbr-tra-1) (Q17308)
Organism: Caenorhabditis briggsae
Function: Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes (By similarity). Promotes female development (By similarity). Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development. Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2 (By similarity). With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate. In hermaphrodites, binds to an intronic regulatory site in the ceh-30 gene, preventing ceh-30 transcription and thereby preventing survival of the CEM (cephalic male) sensory neurons (By similarity). Represses the expression of the transcription factor dmd-3 in hermaphrodites to govern the timing and extent of male tail tip morphogenesis (By similarity). Plays a role in controlling the sex-specific differentiation of PHC sensory neurons and represses the development of male-specific morphological features (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P34708}. Cytoplasm {ECO:0000250|UniProtKB:P34708}. Note=Localization with chromatin in the nucleus in part depends on normal function of wdr-5.1. {ECO:0000250|UniProtKB:P34708}.
Sequence: MMAPSTEDPETVVEAQRRGSFSKKNGNGWTKPGLANGSESKHMEPVTGTNALMAAIDADDQETKLKDPLEKEASTYKSATDRFFQSSHPPSHQTVENPIKLEPPTSSGVTQNGSPVTNSLVPEAAQPLQTVAESSEPTAASAEPTDASSAESSTITVTPVVPVVKFTNQTTPNGSTVATSVGQNVRLTINGKRVGRPPGTFKRPPNNPTTNTSHGEETDSEASTDLICRWKDCMLKFANLKGLVEHVQEKHVQSTEQEHHAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHTGEKPYKCEFSDCEKAFSNASDRAKHQNRTHSNLKPYSCQIGGCQKSYTDPSSLRKHIKAVHGDEEYEKAKKSRPPNYSNRRRPDHRMPPPTSAMSHPYLAPPHVLPPVAAPGVHQQNFINLALAQHHHNQRAQFIANNAALMDPNGSGAAQAAAAAQAAQAQQAQMYQAQAMQQHQFAAQMQQQAVMQVHMQQAALQQAQVAIIQNNLLSTQGIMNQFPMMSPLLTPRAPGNVMSLLQQQQVTPPTPTMMQLTPHTPITPITPITPLTPMGATTGPMFSMPNIMMTTPVRMDIPTSVPAAVPVAPVAPVAPVAPAAPVAPPASSLAEATEPRFRLLRQHMEGAEVAPVLAPQQPLEEDDDMTDDEESGNVAPAVIRNGDGPDDRNSGTGSSSPRSSASSGSGTLEVAGSVAQNGNRSSSTGERGMRSFLIADILQMAHDFQNGRIITDALHKAIFDTSDVTAMFHIYRTFECVCEYLQFTFSAGERLPTWPEVRTIHEYYHSDYDRTRFHASETVRRRDNLFWRFVNYCNSDLPIGGRPILSVSYDEGFEESIDQGSNFGTIPQQLISRMAAEAFDDEDDGFDDAFDIPGLRLGGVEVLIQQQRHRVRRAALKQAQIDYPTAEEDLGYVGGGFGQEDDDHHSYAIYEQQKTVAFVDLSEKPKVEVLTDEDFMEQFKAAEARCQARLAIEPMVKVARTVINGKVVEYTESQLFSPPVSRRTIYSMLKQFPEHQENLLKFITLHVDKCELENVIPSREYMSDMESSFFAHHRIVRAALRARGEITEAEEAEYQQSSNLMYNQDFAALMFPELDESHDDFLNDLPISSRRRSSDSDSKEAPSMKKPRSF
InterPro domains: - IPR056436: ZIC1-5/GLI1-3like, C2H2 zinc finger (domain) [264-292]
- IPR013087: Zinc finger C2H2-type (domain) [226-385]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [226-375]
- IPR043359: C2H2-type zinc-finger protein GLI-like (family) [85-518]
Interaction partners: - Sex-determining transformer protein 2
- Sex-determination protein fem-3
- Protein CBR-DMD-3
- Protein CBR-HER-1
- Protein CBR-MAB-3.1
- Protein CBR-MAB-3.2
- XO lethal protein 1 homolog
- FOG-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0010942 (positive regulation of cell death), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048731 (system development), GO:0018992 (germ-line sex determination), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0031324 (negative regulation of cellular metabolic process), GO:0007538 (primary sex determination), GO:0007283 (spermatogenesis), GO:0010941 (regulation of cell death), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0007548 (sex differentiation), GO:0018993 (somatic sex determination), GO:0080090 (regulation of primary metabolic process), GO:0007530 (sex determination), GO:1901216 (positive regulation of neuron death), GO:0061458 (reproductive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0008406 (gonad development), GO:1901214 (regulation of neuron death), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0048232 (male gamete generation), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043523 (regulation of neuron apoptotic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0043525 (positive regulation of neuron apoptotic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)