Protein: PAX-interacting protein 1 (D2A4R5)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Nucleus
Sequence: MAESGQNQAGADVPEDLFRGVKFFVSGEIAEKVVDLLKVGGAERLNYFSDYVTHLICGENAEENDITDATDLYEIPAVTSKWVFASARLKKLVNTKPYVYNLNKLFTNLVFCLSKVGSDREALWAVITYHGGLVQLNLTNKCTHLVTVDTNSPKYEKAANLGADKITVITPDWVVESVKNNALAQADLFHPKLIQWPKVAKHESTIAITGFEPEKVESVEKTNDMVTDSTQALLDKLKQRMPWIQPQTTTTADIVPPNVVAPSFLNKNQPNQPVRTFPQQQSPQPAVVQTNQQIPRSIVHHTPQPQQLVQQQQPPPQQFNVPNQVHLNRLIGQQQQQQQRPTLQQLRGQLAPNQLHQHLLQQRIAQQNQQNAQRPLTIQQQQLLQQQIAQRQLLQNQQQQQPQPQTQFSNVIQQQHILQQQKIFVSQQPNLAVQQQFNQNQQPQQFNQQFVQNQPDLNQPQLVQQPAQFQPNQQLLLNQQTQFNQQQQQAAQPQQQRPQINQHLWQQQQQMTIRHPVNVVQGPRIQWSPTQQPNQPQRQFIHLDAQTHNELQKMNPEQQAMFVQRLKQKQLLMQKQLTQRAGGGHILIRGSVPPGLNPQQQMQWLQRQAKQQGVVLQQQTITQPNIQQQHAPGLSPIQQQQQQQQQQQPQQFDQNQQQQLQLRQYRLQQLQLQREQAQKNQIAAVQQQPVQAGVVRPLGPVIPDSTTNPPEANSQQLVVNAKTKTALANMLSNRLQSGGGTVPVPETIPEPSAAGTLRLMTAQHNAALNPNNRPQDLIALQQQRRVINGPNGEIIRALVPQSGVPGPVIAQTEPPKVQFSPRPAVPMQHRPGPFYGHNPNLKLPPDLFLLGCIFVVVEIERYLDESLPGWKQKIEKHGGEVEKQYCNRVTHVLCETQRHGVVMQALRDCKRCITIYWLSDVMMRKQVLPPWTALHLPTIYLDTTPAAKHLITLSGFTGCERNRVKHMINYTGAKFTSYFSKHNTLLIAAKGEGAKYNHAKKWGIPVVNVQWLTDIMLGNFSALNQMEHIMYQQFPTPPNFSFDPKLVPNLMHAWKMPINISQESYERVKRSSSPVLMPKKAKKMKTEQTDENDNVDEGVEVNANYRILFSMSSETATLQKIVKQLGGIVAKSHHDCTHLVMPSLSRTNKLLFCICREVFIMPEQWLRDSHTAQKFLDEASYSLDTKEFNSEYKCDFTQTLNTRNRSKLFEGKFFWVTPSVFPSKKVLVELVQSCGGIVEKIRRTSAQIEATNINSPYSYIIITHENDIHLVADLLRNKKDKVRIVCSAELIFSAILKQTFEVEPFAVKVL
InterPro domains: - IPR001357: BRCT domain (domain) [13-1302]
- IPR051579: DNA Damage Response and Transcriptional Regulator (family) [14-1305]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [4-1307]
Interaction partners: - Lysine-specific demethylase 6A-like Protein
- non-specific serine/threonine protein kinase
- DNA topoisomerase 2-binding protein 1-A-like Protein
- Structural maintenance of chromosomes 6
- Nibrin
- Retinoblastoma-binding protein 5 homolog-like Protein
- Lysine-specific demethylase 6A-like Protein
- Histone-lysine N-methyltransferase 2C
- E3 ubiquitin-protein ligase CHFR
- Set1/Ash2 histone methyltransferase complex subunit ASH2-like Protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:2000241 (regulation of reproductive process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051726 (regulation of cell cycle), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0051445 (regulation of meiotic cell cycle), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0010564 (regulation of cell cycle process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0040020 (regulation of meiotic nuclear division), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0051783 (regulation of nuclear division), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:1990234 (transferase complex), GO:0035097 (histone methyltransferase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0043227 (membrane-bounded organelle), GO:0044666 (MLL3/4 complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)