Protein: PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc) [Includes: Glucose permease IIC component (PTS system glucose-specific EIIC component); Glucose-specific phosphotransferase enzyme IIB component (EC 2.7.1.199) (PTS system glucose-specific EIIB component)] (P69786)
Organism: Escherichia coli (strain K12)
Function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration and an effector modulating the activity of the transcriptional repressor Mlc.
Subcellular location: Cell inner membrane {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000269|PubMed:15919996, ECO:0000305|PubMed:3129430}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00426, ECO:0000305|PubMed:15919996}.
Sequence: MFKNAFANLQKVGKSLMLPVSVLPIAGILLGVGSANFSWLPAVVSHVMAEAGGSVFANMPLIFAIGVALGFTNNDGVSALAAVVAYGIMVKTMAVVAPLVLHLPAEEIASKHLADTGVLGGIISGAIAAYMFNRFYRIKLPEYLGFFAGKRFVPIISGLAAIFTGVVLSFIWPPIGSAIQTFSQWAAYQNPVVAFGIYGFIERCLVPFGLHHIWNVPFQMQIGEYTNAAGQVFHGDIPRYMAGDPTAGKLSGGFLFKMYGLPAAAIAIWHSAKPENRAKVGGIMISAALTSFLTGITEPIEFSFMFVAPILYIIHAILAGLAFPICILLGMRDGTSFSHGLIDFIVLSGNSSKLWLFPIVGIGYAIVYYTIFRVLIKALDLKTPGREDATEDAKATGTSEMAPALVAAFGGKENITNLDACITRLRVSVADVSKVDQAGLKKLGAAGVVVAGSGVQAIFGTKSDNLKTEMDEYIRNH
InterPro domains: - IPR013013: Phosphotransferase system, EIIC component, type 1 (domain) [3-388]
- IPR011299: PTS system glucose-specific IIBC component (domain) [2-475]
- IPR001996: Phosphotransferase system, IIB component, type 1 (domain) [378-477]
- IPR004719: Phosphotransferase system, maltose/glucose-specific subfamily IIC component (domain) [52-331]
- IPR018113: Phosphotransferase system EIIB, cysteine phosphorylation site (conserved_site) [399-474]
- IPR003352: Phosphotransferase system, EIIC (domain) [13-320]
- IPR050429: Phosphotransferase System Glucose-Specific EIICBA (family) [1-476]
- IPR036878: Glucose permease domain IIB (homologous_superfamily) [396-477]
Interaction partners: - PTS system glucose-specific EIIA component
- DNA-binding transcriptional repressor Mlc
- Phosphocarrier protein HPr
- Glucokinase
- Glucose-6-phosphate isomerase
- Phosphoenolpyruvate-protein phosphotransferase
- PTS system beta-glucoside-specific EIIBCA component
- Glucose-6-phosphate 1-dehydrogenase
- PTS system maltose-specific EIICB component
- PTS system fructose-specific EIIB'BC component
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098739 (import across plasma membrane), GO:0034219 (carbohydrate transmembrane transport), GO:0006810 (transport), GO:0098704 (carbohydrate import across plasma membrane), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0009401 (phosphoenolpyruvate-dependent sugar phosphotransferase system), GO:0008643 (carbohydrate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)