Protein: Zinc finger protein 488 (B8A5Y1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional repressor (By similarity). May have histone methyltransferase activity (Probable). Negatively regulates shh signaling activity in pMN progenitor cells which prevents their switch from motor neuron to oligodendrocyte precursor cell production. Independently of shh activity, also regulates oligodendrocyte formation
Subcellular location: Nucleus
Sequence: MEHSIFPRSLWTNDSKILHHHVADFFSSVQVTQDIPAGTSFGPCVLHNTFYDTIAFIALKSFDKRNKSYVFRVDPEAMKGSPLVVPWLRLVQAAMSEEDQNTEAYLKGGQLHFRTIRDVKEGEELLVWYDEELSHLLGFRDIKAKALTDGYTCTRCGQAFKNENPFLAHCRFLCTQEKVDIIRPINQQKPEVKRHRKVIDFHNIARDLEDKMNTSSFEDTTILRKRKQEPFLTPKSKKTVLLEKTNITNESNTTNANKDCRAFRDLSEPTDNAQTNESKISKNSAFTEVRKAPEPSNPEKSSRDIMAPEVGLQSNCSAFSFVVPKSARSEQKSAFCEPSKRALAEAQNPSPPDTDNSLDSFKSKSSLGYRNVLASHLFPTDLAGSHSGGGMSAPLTSGGSYYYAPEHWTRAIGGQLQSTSSLTLLPPTFTPLGVSVQNWCAKCNLSFRMTSDLVFHMRSHHKKEFAAEAQVRRRREEKLTCPICHEYFRERHHLSRHMTSHN
InterPro domains: - IPR044402: PRDM8-like, PR/SET domain (domain) [5-137]
- IPR046341: SET domain superfamily (homologous_superfamily) [3-137]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [439-501]
- IPR013087: Zinc finger C2H2-type (domain) [151-502]
- IPR052296: Transcriptional Repressor and Histone Methyltransferase (family) [1-502]
- IPR001214: SET domain (domain) [8-138]
Interaction partners: - Class E basic helix-loop-helix protein 22
- PR domain zinc finger protein 5
- PR domain zinc finger protein 10
- PR domain zinc finger protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity), GO:0042800 (histone H3K4 methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003407 (neural retina development), GO:0060041 (retina development in camera-type eye), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0060219 (camera-type eye photoreceptor cell differentiation), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0042670 (retinal cone cell differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)