Protein: Sodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4) (P31652)
Organism: Rattus norvegicus (Rat)
Function: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11709063, ECO:0000269|PubMed:15627510, ECO:0000269|PubMed:16870614, ECO:0000269|PubMed:1948036, ECO:0000269|PubMed:8601815}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:16870614}; Multi-pass membrane protein {ECO:0000255}. Synapse {ECO:0000250|UniProtKB:Q60857}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q60857}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q60857}. Note=Could be part of recycling endosomes (PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (PubMed:11709063). Density of transporter molecules on the plasma membrane is also regulated by serotonin (By similarity). Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity). {ECO:0000250|UniProtKB:P31645, ECO:0000250|UniProtKB:Q60857, ECO:0000269|PubMed:11709063, ECO:0000269|PubMed:16870614}.
Sequence: METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
InterPro domains: - IPR013086: Sodium:neurotransmitter symporter, serotonin, N-terminal (domain) [23-64]
- IPR000175: Sodium:neurotransmitter symporter (family) [72-615]
- IPR037272: Sodium:neurotransmitter symporter superfamily (homologous_superfamily) [79-597]
Interaction partners: - 5-hydroxytryptamine receptor 1A
- 5-hydroxytryptamine receptor 2A
- Synaptic vesicular amine transporter
- 5-hydroxytryptamine receptor 1B
- Amine oxidase [flavin-containing] A
- 5-hydroxytryptamine receptor 2B
- Tryptophan 5-hydroxylase 1
- 5-hydroxytryptamine receptor 1D
- Tryptophan 5-hydroxylase 2
- 5-hydroxytryptamine receptor 2C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008504 (monoamine transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015296 (monoatomic anion:monoatomic cation symporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015370 (solute:sodium symporter activity), GO:0015377 (chloride:monoatomic cation symporter activity), GO:0015378 (sodium:chloride symporter activity), GO:0015373 (monoatomic anion:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0071702 (organic substance transport), GO:0098662 (inorganic cation transmembrane transport), GO:0071705 (nitrogen compound transport), GO:0015844 (monoamine transport), GO:0015850 (organic hydroxy compound transport), GO:0015695 (organic cation transport), GO:0051937 (catecholamine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0042734 (presynaptic membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0098691 (dopaminergic synapse), GO:0043005 (neuron projection), GO:0097060 (synaptic membrane)