Protein: Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor) (P04823)
Organism: Rattus norvegicus (Rat)
Function: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Stimulates also mature basophils, eosinophils, and monocytes to become functionally activated. In addition, plays an important role in neural cell proliferation and survival. Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation. Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (By similarity). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program. Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (By similarity).
Subcellular location: Secreted.
Sequence: MVLASSTTSILCMLLPLLMLFHQGLQISDRGSDAHHLLRTLDCRTIALEILVKLPVSGLNNSDDKANLRNSTLRRVNLDEFLKSQEEFDSQDTTDIKSKLQKLKCCIPAAASDSVLPGVYNKDLDDFKKKLRFYVIHLKDLQPVSVSRPPQPTSSSDNFRPMTVEC
InterPro domains: - IPR002183: Interleukin-3 (family) [8-153]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [30-156]
Interaction partners: - Interleukin-3 receptor subunit alpha
- Interleukin-5
- Colony stimulating factor 2 receptor subunit beta
- Interleukin-2
- Granulocyte-macrophage colony-stimulating factor
- Kit ligand
- Interleukin-6
- Interferon gamma
- Interleukin-1 alpha
- Interleukin-7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005126 (cytokine receptor binding), GO:0070851 (growth factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:0042127 (regulation of cell population proliferation), GO:0043207 (response to external biotic stimulus), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0048731 (system development), GO:0009617 (response to bacterium), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:0009617 (response to bacterium), GO:0009790 (embryo development), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0031099 (regeneration), GO:0010033 (response to organic substance), GO:0008284 (positive regulation of cell population proliferation), GO:0031100 (animal organ regeneration), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0032496 (response to lipopolysaccharide), GO:0007399 (nervous system development), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0036293 (response to decreased oxygen levels), GO:0007417 (central nervous system development), GO:0007417 (central nervous system development), GO:0002237 (response to molecule of bacterial origin), GO:0007417 (central nervous system development), GO:0030855 (epithelial cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0045471 (response to ethanol), GO:0048699 (generation of neurons), GO:0010821 (regulation of mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)