Protein: Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (P52709)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MRLNCFRIFVHIQKPTQIFKPFYRSLSSEASDKYHFVNGHKMSKAPTDMAPWPAFIEERIKLWDKLKAEYDAEIAAKESEPIQITLPDGKIHEGKTWRTTPFEIAERISKGLAEAAVIAKVNGAVWDLDRPFEGNAKLELLKFDDDEAKQVFWHSSAHVLGEAMERYCGGHLCYGPPIQEGFYYDMWHENRTICPDDFPKIDQIVKAAVKDKQKFERLEMTKEDLLEMFKYNEFKVRIITEKIHTPKTTVYRCGPLIDLCRGPHVRHTGKVKAMAITKNSSSYWEGKADAESLQRLYGISFPDSKQLKEWQKLQEEAAKRDHRKLGKEHDLFFFHQLSPGSAFWYPKGAHIYNKLVDFIRKQYRRRGFTEVITPNMYNKKLWETSGHWQHYSEDMFKIEVEKEEFGLKPMNCPGHCLMFGHMPHTYNELPFRFADFGVLHRNEMSGALTGLTRVRRFQQDDAHIFCRQDQISEEIKQCLDFLEYAYEKVFGFTFKLNLSTRPEGFLGNIETWDKAEADLTNALNASGRKWVLNPGDGAFYGPKIDITIQDALKRNFQCATIQLDFQLPNQFDLSYFDEKGEKQRPVMIHRAVLGSVERMTAILTESYGGKWPFWLSPRQCKIITVHESVRDYANDVKKQIFEAGFEIEYEENCGDTMNKQVRKAQLAQFNFILVIGAKEKENGTVNVRTRDNAVRGEVALDKLISKFRRFADEYVADTEKSEEWA
InterPro domains: - IPR012947: Threonyl/alanyl tRNA synthetase, SAD (domain) [248-297]
- IPR047246: Threonine-tRNA ligase, class IIa, anticodon-binding domain (domain) [617-708]
- IPR036621: Anticodon-binding domain superfamily (homologous_superfamily) [611-723]
- IPR033728: Threonine-tRNA ligase catalytic core domain (domain) [320-617]
- IPR045864: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) (homologous_superfamily) [303-610]
- IPR012676: TGS-like (homologous_superfamily) [82-142]
- IPR004154: Anticodon-binding (domain) [619-708]
- IPR004095: TGS (domain) [80-142]
- IPR002320: Threonine-tRNA ligase, class IIa (family) [147-709]
- IPR006195: Aminoacyl-tRNA synthetase, class II (domain) [340-612]
- IPR012675: Beta-grasp domain superfamily (homologous_superfamily) [80-141]
- IPR018163: Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily (homologous_superfamily) [144-319]
- IPR002314: Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) (domain) [396-607]
Interaction partners: - Histidine--tRNA ligase
- Leucine--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Lysine--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- Obg-like ATPase 1
- Asparagine--tRNA ligase, cytoplasmic
- Valine--tRNA ligase
- Methionine--tRNA ligase, cytoplasmic
- Probable glutamine--tRNA ligase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016875 (ligase activity, forming carbon-oxygen bonds), GO:0004812 (aminoacyl-tRNA ligase activity), GO:0140101 (catalytic activity, acting on a tRNA)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0008340 (determination of adult lifespan)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)