Protein: Phosphoacetylglucosamine mutase 1 (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Q09687)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MTKNKKYSYGTAGFRTKASDLEAAVYSSGVAAALRSMELKGKTIGVMITASHNPVEDNGVKIIDADGGMLAMEWEDKCTQLANAPSKAEFDFLIKQFLTPTTCQPKVIIGYDTRPSSPRLAELLKVCLDEMSASYIDYGYITTPQLHWLVRLINKSTAASFLEEGPPITEYYDTLTSAFSKIDPSMQDSPTVSRVVVDCANGVGSQPLKTVAGLVKDSLSIELVNTDVRASELLNNGCGADFVKTKQSPPLALEGKIKPNQLYASIDGDADRLIFYYINQNRKFHLLDGDKISTALVGYLNILVKKSGMPFSLGVVQTAYANGASTEYLQDLGITTVFTPTGVKHLHKAAKEFDIGVYFEANGHGTVLFSDKALANLAHPFFTPSPVQAAAIEQLQSYSVLINQAIGDAISDLLATISVLNALHWDASAWSNTYKDLPNKLAKVKVSDRTIYKSTDAERRLVSPDGLQEKIDALVAKYEKGRSFVRASGTEDVVRVYAEASTKQAADELCEKVCQLVL
InterPro domains: - IPR049023: Phosphoacetylglucosamine mutase AMG1, domain II (domain) [170-273]
- IPR016657: Phosphoacetylglucosamine mutase (family) [1-518]
- IPR049022: Phosphoacetylglucosamine mutase AMG1, domain III (domain) [288-425]
- IPR016066: Alpha-D-phosphohexomutase, conserved site (conserved_site) [45-54]
- IPR016055: Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III (homologous_superfamily) [5-366]
- IPR005843: Alpha-D-phosphohexomutase, C-terminal (domain) [443-514]
- IPR036900: Alpha-D-phosphohexomutase, C-terminal domain superfamily (homologous_superfamily) [426-517]
- IPR005844: Alpha-D-phosphohexomutase, alpha/beta/alpha domain I (domain) [32-154]
Interaction partners: - Probable UDP-N-acetylglucosamine pyrophosphorylase
- Glucosamine 6-phosphate N-acetyltransferase
- Probable glutamine--fructose-6-phosphate aminotransferase
- Phosphoacetylglucosamine mutase 2
- Phosphoglucomutase
- Ornithine carbamoyltransferase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0016868 (intramolecular transferase activity, phosphotransferases)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0009112 (nucleobase metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0006144 (purine nucleobase metabolic process), GO:0009117 (nucleotide metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0046112 (nucleobase biosynthetic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009124 (nucleoside monophosphate biosynthetic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0009113 (purine nucleobase biosynthetic process), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0009167 (purine ribonucleoside monophosphate metabolic process), GO:0046040 (IMP metabolic process), GO:0009127 (purine nucleoside monophosphate biosynthetic process), GO:0009156 (ribonucleoside monophosphate biosynthetic process), GO:0006188 (IMP biosynthetic process), GO:0009168 (purine ribonucleoside monophosphate biosynthetic process), GO:0006189 ('de novo' IMP biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)