Protein: RHOMBOID-like protein 10, chloroplastic (AtRBL10) (EC 3.4.21.-) (F4ICF4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Required for correct root growth, floral development, fertility and photoprotection. May be involved in TIC22 processing during its import and in AOS accumulation in the chloroplast membrane.
Subcellular location: Plastid, chloroplast membrane {ECO:0000269|PubMed:22416142, ECO:0000269|PubMed:22738221}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes probably to the inner membrane. {ECO:0000303|PubMed:22738221}.
Sequence: MVSVSLSHHNLWPPESGSTAFRGFATAASVHACHHVSRHLRLDFHLRSSLKKLQHFSDDARMKFARYQRVFVFNGANFLKSRVDIRLSQSSPFVCFFNGGESRLNPRGGEEGSSNPETSKRNTVNGRRWTNVLLAINVIMYIAQIASDGKVLTWGAKINSLIERGQLWRLATASVLHANPMHLMINCYSLNSIGPTAESLGGPKRFLAVYLTSAVAKPILRVLGSAMSYWFNKAPSVGASGAIFGLVGSVAVFVIRHKQMVRGGNEDLMQIAQIIALNMAMGLMSRRIDNWGHIGGLLGGTAMTWLLGPQWKYEYTTRDGRRVFMDSAPIPLLLRWRNEQRRL
InterPro domains: - IPR035952: Rhomboid-like superfamily (homologous_superfamily) [123-312]
- IPR022764: Peptidase S54, rhomboid domain (domain) [164-309]
- IPR050925: Rhomboid protease S54 (family) [21-311]
Interaction partners: - Rhomboid-like protein 11, chloroplastic
- Rhomboid-like protein 16, chloroplastic
- Rhomboid-like protein 17, chloroplastic
- Sec-independent protein translocase protein TATA, chloroplastic
- Signal peptide peptidase
- Rhomboid-like protein 20
- Rhomboid-like protein 18
- Rhomboid-like protein 15
- RHOMBOID-like protein 13
- Rhomboid-like protein 14, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051604 (protein maturation), GO:0006508 (proteolysis), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0061024 (membrane organization), GO:0009668 (plastid membrane organization), GO:0009657 (plastid organization), GO:0010027 (thylakoid membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0009507 (chloroplast), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031969 (chloroplast membrane), GO:0009941 (chloroplast envelope), GO:0009528 (plastid inner membrane), GO:0009706 (chloroplast inner membrane)