Protein: Lysosomal acid lipase/cholesteryl ester hydrolase (Q9Z0M5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions
Subcellular location: Lysosome
Sequence: MQLQGLVFVFTIGILLSRVPTGTVSAVDPEVNMNVTEIIMRWGYPGEEHSVLTGDGYILSIHRIPRGRKNHFGKGPRPVVYLQHGLLADSSNWVTNIDNSSLGFLLADAGFDVWMGNSRGNTWSLKHKTLSVSQDEFWAFSFDEMAKYDLPASINYILNKTGQEQIYYVGHSQGCTIGFIAFSQMPELAKKIKMFLVLAPVLSLNFASGPLLQLGRLPDPLLKDMFGQKQFLPQSAMLKWLSIHVCTHVIMKELCANVFFLLCGFNEKNLNMSRVDVYTTHCPAGTSVQNMLHWGQVFKYRKLQAFDWGSSEKNYFHYNQSFPPSYNIKNMRLPTALWSGGRDWLADINDITILLTQIPKLVYHKNIPEWDHLDFIWGLDAPWKLYDEIISLMKKYQ
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [21-395]
- IPR025483: Lipase, eukaryotic (family) [8-397]
- IPR000073: Alpha/beta hydrolase fold-1 (domain) [78-378]
Interaction partners: - 7-dehydrocholesterol reductase
- Bile salt-activated lipase
- Delta(24)-sterol reductase
- Cholesterol 25-hydroxylase
- Cytochrome P450 7A1
- Sterol 26-hydroxylase, mitochondrial
- Apolipoprotein B-100
- Cholesterol 24-hydroxylase
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Sulfotransferase 2B1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0001776 (leukocyte homeostasis), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0008283 (cell population proliferation), GO:0048771 (tissue remodeling), GO:0006952 (defense response), GO:0035295 (tube development), GO:0048872 (homeostasis of number of cells), GO:0000902 (cell morphogenesis), GO:0001894 (tissue homeostasis), GO:0048513 (animal organ development), GO:0060249 (anatomical structure homeostasis), GO:0048731 (system development), GO:0050673 (epithelial cell proliferation), GO:0060541 (respiratory system development), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0006954 (inflammatory response), GO:0048873 (homeostasis of number of cells within a tissue)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)