Protein: RecQ-like DNA helicase BLM (A0A8M6YW51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MSSLPQNNLKEHLERHNNAAQNKLSLLKPKPGGFCFKKKSSSGISKVEVPQKVTGSSVLANRSVNIPSNFEVTKNPVTFSQKPERVAPKVNFFTAPSKPKTNTVNPLANPFALNKTPLVQSTIKALPKSAALPKDSTNDQTVELKHDISQLSFNEWDDLDDFETPVKSRVASPVAGTSTKKPSVSDQNTSSSCSSKCEETKVNEESQATETITAPKDVLSAANGVSTETAEREPEDSPIKKSKRPKKSVQHTALLSDTEDEEIIHCVSPDTNQKNFKSVAVAEKDKWGEPNVIDSDDCEENNHYEGFEDFIPPSPIPEEISLSVSDKEKSSSEPVTPANKKESSRSASGLPAPLDQSAKGLKGADDALFSVMESICCLVDTIPEHELIALTCGTELLLQRAHRKRILAKGGSSRTSHSDSVSTPGFLNRPTFGVTPSNLTSLTPVTSGKREGVKTGFSFRKSIASVMSVGDESVFEDSDCIINGVETPGGTWNPNSSTKISAGRDTFNGSIQTLSKPESKTDKCYSRLSFNESSNQTDLFYSPKRVDSGSRNADSSVEINIAGSSSLRTGAEPVDDFLLDDFDIDDFDENDIPDYYEEPPSVLESRNNSGVKTPSVQEGGSSKSFERKTFTPPAPKSIKTPNPEPLYRNPAHDRFRGFNFPHSPEMMKIFHKKFGLHQFRFNQLEAINASLLGEDTFVLMPTGGGKSLCYQLPACVSAGVTVVISPLRSLIVDQVQKLTTLDICATSLSGDKKDSEAARIYMQLSRKDPAIKLLYATPEKVCASGRMISALQNLYERGLLARLVIDEAHCVSQWGHDFRPDYKRLHELRRMFPNVPIMALTATATPRVQKDILNQLAMTRPQVFTMSFNRNNLKYSVLPKKPKKVDEECIQWIKKYYPRDSGIVYCLSRNDCDTLADSLQRAGIAALAYHAGLSDSDREYVQNKWINQDGCQVMCATIAFGMGIDKPDVRYVIHASLPKSVEGYYQESGRAGRDGEISHCVLFYSYSDVIRIKRLIAMDKDGNQQSKATHINNLHSMVHFCENVAECRRIQLLAYFGEHTFNTSFCKEHPEVICDNCARPNKYKSRNVTDDVKKIARFVQDNCEKVGNRYGKSAQQNRLTLNMLVEIFLGSKSARIQTGMFGVGAAYSKHNAERLFKKLVLDNVLMEDLYITNSGQAVAYISAGPKAMSVLNGCMQVEFHETESASSIRKHRASVCEKVSKREEMVKKCLGELNDLCKKLGKVFGIHYYNIFSTATLKKIAETLSADPEVLLQIDGVTEDKLEKYGAEFIELLQKYSEWQLPAEAQAESSGWIDTTRGHQNDEDDNDDDDEGGGDVTSTYFRSNSGRGAKRKQGSYSRKPKRRKGSSGQNSSAKGGYSSNWSSSRGGGRGGGYRGGSRGAGRGSRSAPSGSAAKRPGFMSLPTPQAAARPFLKPSFSHL
InterPro domains: - IPR010997: HRDC-like superfamily (homologous_superfamily) [1228-1299]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [683-850]
- IPR004589: DNA helicase, ATP-dependent, RecQ type (family) [668-1152]
- IPR001650: Helicase, C-terminal domain-like (domain) [888-1035]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [675-878]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [638-1115]
- IPR032284: ATP-dependent DNA helicase RecQ, zinc-binding domain (domain) [1006-1077]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [1084-1204]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [1087-1199]
- IPR002121: HRDC domain (domain) [1223-1303]
- IPR002464: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (conserved_site) [801-810]
- IPR018982: RQC domain (domain) [1084-1205]
- IPR044876: HRDC domain superfamily (homologous_superfamily) [1218-1309]
- IPR012532: BDHCT (domain) [368-408]
- IPR032437: RecQ-like DNA helicase BLM, N-terminal domain (domain) [1-336]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0004386 (helicase activity), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0140097 (catalytic activity, acting on DNA), GO:0003678 (DNA helicase activity), GO:0043138 (3'-5' DNA helicase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051053 (negative regulation of DNA metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0045910 (negative regulation of DNA recombination), GO:0000018 (regulation of DNA recombination), GO:0000019 (regulation of mitotic recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)