Protein: Monocarboxylate transporter 3 (MCT 3) (Solute carrier family 16 member 8) (O95907)
Organism: Homo sapiens (Human)
Function: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity).
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217}.
Sequence: MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [17-432]
- IPR020846: Major facilitator superfamily domain (domain) [18-435]
- IPR004743: Monocarboxylate transporter (family) [1-460]
- IPR050327: Proton-linked Monocarboxylate Transporter (family) [13-433]
- IPR011701: Major facilitator superfamily (family) [27-396]
Interaction partners: - Basigin
- Embigin
- Sialin
- Monocarboxylate transporter 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0097159 (organic cyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0003676 (nucleic acid binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0003723 (RNA binding), GO:0015355 (secondary active monocarboxylate transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015295 (solute:proton symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)