Protein: Cation channel sperm-associated auxiliary subunit epsilon (CatSper-epsilon) (CatSperepsilon) (C1orf101-like protein) (P0DP43)
Organism: Mus musculus (Mouse)
Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:28226241}; Single-pass type I membrane protein {ECO:0000255}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000269|PubMed:28226241}.
Sequence: MPSAGQRKPGSLLALQALQKWLLRGGVGAMLARQVVAALLLWLSCCVSALWRYYINSQDYSIFSTRSSIKLEYEGNSFVSWKIPESCKVENTTSPKTTLHCKRAGIHTIKPIAGNQEVERHLTVDNSYICYLWYFTVVDVYYNLSQIVTIWVYDPESASTEELIWTAKKPSLSSRVLTKQMNTLGQRPFIFTVEKRLTYHPGPLTSEGTWVIHLPMSSDDIAKVIRGNKVAFQDCFIANLYFMLTYPMTIISEPPGYEPLTVPPGSPLMLSWDTCISTFALLATDQETFQTNDSFQTWTRVRAPPGILSDAQRHSLRDVIIFDQGTLFLVDGTVYLRTEDEFTKLDESRGISETGILGFSKRRWCQIRYLYKLASKKSILIAWSKTTVYAGYATFRFVTLTDTAKLKDFLKLPQTDTLEVMSVEYLWHPLEAAVLLSHCSVCTTNTRNIRIVIYSAIFQTWTLQDFELQLPKEAILEFRFLYSAMPDIIMWDQHHVYYSYKNFTVVGTISTPSGETNLSSLSQGSKIHQVLTDRIGNVVVKMENNVMFYIKADITEAVILHTWVNTTAKTVVLFDKSFEVCILYYNENLDEKYQLQTQPYPLILELQSINKDLGDWCPYLAFQHNIHSQFYHMDKGESLTIWSQIVYPENRGLYIVVEHYGSSVMTWTQNLEYEIASGFCTKTMITRFFQTTNYELVDNYYQLQKENTGLMLLQFRPSEFSRTCLTAKPVFEIDVGCDSSKYIMVRGFNKSRCQRRDFSYVIDKELLRESLSDNLKVRYDVAKYGCPLTLELGQMFQPIVELYDENGFIKIVDANFILWEIHGRNDYTFNSTMEQNGCINEAQTWDSMIEENPDIPLDDVWGPQNYRPCFSYAIGKPGDLGQPYEILNYSNKNHIKWPMTYAGMYVYRLKILDPNYSFCNLTTIFAIESLGMIPRSSVYLVAALIFVLMLTFISILVLSYFWYLKIYRQFIIEPLHKRPAKQKKN
InterPro domains: - IPR053816: CATSPERE, beta-propeller domain (domain) [257-610]
- IPR053815: CATSPERE, Ig-like domain (domain) [621-731]
- IPR028751: Cation channel sperm-associated auxiliary subunit delta/epsilon (family) [39-985]
- IPR053817: CATSPERE, second N-terminal domain (domain) [130-215]
- IPR053814: CATSPERD/E, C-terminal domain (domain) [758-960]
- IPR053818: CATSPERE, first N-terminal domain (domain) [39-125]
Interaction partners: - Cation channel sperm-associated auxiliary subunit gamma 2
- Cation channel sperm-associated protein 2
- Cation channel sperm-associated auxiliary subunit beta
- Cation channel sperm-associated auxiliary subunit delta
- Cation channel sperm-associated auxiliary subunit zeta
- EF-hand calcium-binding domain-containing protein 9
- Cation channel sperm-associated protein 1
- Cation channel sperm-associated protein 4
- Cation channel sperm-associated protein 3
- Solute carrier organic anion transporter family member 6C1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007018 (microtubule-based movement), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048515 (spermatid differentiation), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0030317 (flagellated sperm motility), GO:0048240 (sperm capacitation), GO:0007283 (spermatogenesis), GO:0071695 (anatomical structure maturation), GO:0003341 (cilium movement), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0060294 (cilium movement involved in cell motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097228 (sperm principal piece), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium), GO:0036126 (sperm flagellum)