Protein: Sodium-dependent phosphate transporter 2 (Q63488)
Organism: Rattus norvegicus (Rat)
Function: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion. Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules. Parathyroid hormone decreases its abundance in brush border membrane
Sequence: MAMDGYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQWMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYTGAPVLGLSLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQEAESPVFKELPGAKASDDSAVPLTSLAGEAAGASEGTSAGNHPRASYGRALSMTHGSAKSPISNGTFGFEGHMRNDGHVYHTVHKDSGLYKDLLHKIHVDKGPEEKPAQENNYRLLRRNNSYTCYTAAICGMPVHATFRASDTSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMRLASELTDPDQPHEDPAEDEKEEKDSAEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFIAWFVTVPVAGLFSAAIMALLMYICGFVSSSR
InterPro domains: - IPR001204: Phosphate transporter (family) [1-648]
Interaction partners: - Solute carrier family 53 member 1
- Sodium-dependent phosphate transport protein 2C
- Sodium-dependent phosphate transport protein 2A
- Myogenesis-regulating glycosidase
- Fibroblast growth factor 23
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0005436 (sodium:phosphate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)