Protein: HECT-type E3 ubiquitin transferase (D6W6Q2)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Nucleus
Sequence: MKIDRSRVRKSTSDVPIECQQLIERLQACSRTELLEELSKINTWTFGKCELLHWALVLDVFDKILGEAGRKSFENKWALKCDTHYNSTEKKLLLWILHFTTLLIEHSFSRHLYNSLEHLLVLLESNDMSVVLGVLNLLYMFSKRSNFISRLSPDKKNSLLSRLHHLAENWGGKENGFGLADCCRADETLPFSATTVHVEFHRESDDPKEAPSKNSKNSPHIIHIEHVDKIHRTPAEIMKSLLGIYYVPPDKQMWLFTRVRLAYHFADYNNRLLCVQARLQALSVLVYSNAIQDSPHNLLYNGLLEELVELVEMKDPHLVEIRSAALRTLTAIIHLDRNPHIPKKPGSRLNNIIDVTGASQYHGFLPLLVRNCIITLTNQSSENQSKKDDTEIIDVDCDEAKVMENSDVTMSPQQIADPNAKFPLSLATALFSFLYHLASYEAGGEALVSCGMMESLLQVINWHGVELEHITFVTRAVRVIDLITNIDMQAFQTHGGLQSFINRLDVEVKLCKAEQLYEIKTTVTDQTFLEEGAAGPSTEAPENSSEPTKLVDLEYHSENVGKTCLPQRAALLKSMLNFLKKALQDSTFSDNIRHLMEGTLPNSLKNIIANAEYYGPSLFLLATDVVTVYVYQEPSLLSALQDNGLIEVVLHSLLVKEIPATREVLGSLPNVFSALCLNNRGLQQFIKMKPFEKTFSVLLSPDYLPAMRRRRSSEPMADTACNLGNAMDELMRHQPSLKSDAIKAIIDLLEELVNLGTDPKYICWKPHSKSEVSPSSSTRSATNTEGSSDEEDEDEEEASTSSQNAQNDAQVQQENSERTPIALIDYILNTMKFIDAILSNNSTDDHCREFVQQGGLRPLLKILGLPNLPVNCPVTNPAQAVATVCKSILNLAHETNLFKEGLAQLSEVLEVLKPMYTKLDVPSGPKLLLELAGASNVENAFNNASVTPLLHAMGAAHGYIIMLVHVCRTGQSEIRNLSLQNWGSEEGLRVIKGLADLYTSLVWESTLLLAYCSEEFIPSDFTREDIEKLNAFFDKCESSNTGSDSTVNVASAMEALTTNPPSIEMDVDQEGITLNLSTSLKYIKPLLGASSRLGRALAELFGLLVKLCVGSPIRQRRGQNIIAAPPLPTPYARSVATALNVLLADGLDYERLPACPLIKSRITFLICSVGFTSPMLFDEKRYPYHLMLKKFVALGGQATFFNTFRWALSAGGTIPIEKAFEDGPLPEGTAGFLDAWLMLLEKMVNPKAILESPHIISNRSSQSSTYRGYNFDPLKYLIQIHKLAFEAVILLWNKAPLTTYGTRLSENILTVLRHILRGEKIIKEKLKSEENMSTDLSRPKSSSGNSSREPEVNPDSLRQLMDMGFSREHVTDALLNTLTVEQATDYLLTNPPSLYRISQSFMNSDEDDQMMQAIAISLGVSNNLPSVSKKRQIQDDGKPLAESLIDEFTNHALEACLRLLDNTPECVHKICELLVTIMKRNGRTFRDNLLDTLVKEIYENAKNVCYALKQPECELPSVAKLPCATRLANYLHLYILFFEVSSYFEMKIPCALAVHKIDLINLLIKLICMAEKVMSRSEKVTEPKWLASSFLLIDAASKVATCAHRKRNMHLSTTRVWRWFHLETGKWTPYSNSNNKLINDAYWNGEQSVRVICGRRRYTVTFSNMLQLNDESGNNRPICMTLINSGLSSCSDVFIVNLEESLRAELTEKEDKRCQYVRNLDKAQETKIIRACVKLMHLTIEKDLLHSILQICIRLTRDFELAKIFVQEGGVKCLIAMKQVREFPSFGILATILIRHTLEEPNTLSYAIEKIIRARTLSTIPPYYKELLYLTRQIGGAVTRSPETFFEVAKNILRVDTDVNREDVDSRIPVKTEPPTRTRAPPLEEVVSNEVICDLLNALLNPLEVVDDTQPQTSPQNAPPETSSTKPSESVTGDNNDSGSETPAQAEANADDQSEPIQSMKKMMLPKSVILKILGDAVVSYGPVARIITEYTYKAGSNECIKEDCTALAFILDYILPEADDLSDSDCATMCRMLIAAIASSNHSPEAQFTLVSEVRAALLRALVMPESTEKHSQVQLIAGIISIMIDNCPSSQARVKSQPPTPQMNNIVRLMIRKSLFNDLARVPHFLDLSSPNTPFTVNACLKSLEALSRIVNQPVPANVQKSRKNQQATDESAGTQSGTSTEGTNAQREVVIDDSVVIEDSENTEHDIAVVTSTIEVEANENENVLVHMIDQLLEQGNDNNQSFSDVASSRNHTMDIDEDGNLTFEHERDATEELMSTDSGESDSNPSDQVEDEENDDNEGDDENIDDADDTNYDDDDGSDRRRASYMDRNDDVLMIQYTNPGAENEVVTRMVAYPMGDHAAFPMPLFDEINNSSDHTGPIVHPLLLSRTANESNSNTATRTQRVTRARRYQYLFNPRNPNPPVILQRLLGPHEPQVTLASANSILGGPPEMRESARLVVMDNFGLLPSHEEQIDFVDQSSGYLLGPSLAATLNHISPVLHWWNIESKCLDYESVYDVTTEVCNKLIPILIKQRNVEIVEKRKSHDTLRRFKFFEDDYIKPAEDSTEPNATDGTDEDIDGVPLETSSNDDRSEANNRMDSSPFIGFDNGTEQVRRNSRPSIRSDTVRHNEENNEGGDRNGRSVNPFEIPTLSPYTPPSRLPVIFFPPNVLHSPDAVEQAYQENNEENNESGDRNGRSVNPFGISTIGTLSPYTPPSRLTDMFSPSVLHPPEMVEHADQENNEAPLTRENEDENYCCNRNRPTCDSVGDIFEDSLNQQINSLANSERDPIPTEEAPTTNSIQESGEITAMPQQQTTSEPGPSSDQTEEIPDGVDPSFLEALPPDMRQEVLEQHRILRLQQRIAARTENPEAAAGTTTEVSPEFLAALPPSLQEEVLSQQRLEQQRQAAAQANPNEPVDAGAFFETLQPSLRTMILSDMEDSQMSALPPDLAAEAQTLRRDWEARNRQLVQERILQSNLTSIIRHSARARQQPLHHSSGHFHRAQWTHWNREFMNNSATPTPPLKIRGRQLLDHEGLSCLLVLLFTDDPHLGKLRLHRVIRNLCYHAPTREWIVNALLSIIDKSVHVKPDESLNKPARKMPKPGPLSSKLMTDSKLLQNNGNWLNIRMEAALGCSANVFIINRSSTGKRSDRSAASSISIHPQAAPIVCRNALDLFTSLAKAFPSCLLPLKCIRDDREDKNNLSPVRVKSESFGDFWEILLRLDSASTKKGKSIPKSSSSNTAVEPDNKVITFEQSVFGQLLNMLASPVVNRNTQLTDNLLRLLSVITSGMPELAKPPTVPIKATKNKLKENTTPTNALHLAVNVITYKNCSEEGLEFITNLLLNLASSTLEMSYMILNLLLSGAVRIGEIVREQINNMLIELKEYNAQKRKVTNNDELGPSTSKGTIADRFTKETVIITASTKVKASCELQLPSMVPLTSKSSSQLFFLRVLRVIVQIRNSFKQNVKRADASWCYDIPALSEQLSSIDSLWETLSQCLSELEHTPDHHAVLVLQPAVEAFFLVHSPQQGPSKKQQDTEPSSSQAPESRTTTSAESGDLPPAPSTENKFVNPETELHTAESTSKTVPPEQQKFLSFAEKHRRVLNQILRQSTSHLADGPFAVLVDHTRILDFDIKRRYFRSELERMDQGIRREETAVHVRRSNIFEDSFRELYRRTPEEWKNRFYIVFEDEEGQDAGGLLREWYVIISRDIFNPMYALFTVSPGDRVTYMINSASHYNPNHLCYYKFVGRVIAKAIYDNKLLECYFTRSFYKHILGIPVKYTDMESEDYSFYRGLVYLMENNINNLGLDLTFSTEINEFGVTETRDLIVNGRHVPVTEETKMEYIRLSCQMKMTGAIKQQLNAFLDGFYDIIPMRLISIFNEQELELLISGLPNVDIDDLKANTEYHKYQANSLQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGVQKFQIHRDDRSTDRLPSAHTCFNQLDLPVYETYDKLRSYLLKAIHECSEGFGFA
InterPro domains: - IPR004170: WWE domain (domain) [1603-1680]
- IPR000569: HECT domain (domain) [3657-4012]
- IPR010309: E3 ubiquitin ligase, domain of unknown function DUF908 (domain) [89-373]
- IPR016024: Armadillo-type fold (homologous_superfamily) [1392-2323]
- IPR025527: HUWE1/REV1, ubiquitin-binding motif (conserved_site) [2829-2944]
- IPR035983: HECT, E3 ligase catalytic domain (homologous_superfamily) [3639-4005]
- IPR010314: E3 ubiquitin ligase, domain of unknown function DUF913 (domain) [474-870]
- IPR041918: HUWE1, UBA domain (domain) [1352-1391]
- IPR037197: WWE domain superfamily (homologous_superfamily) [1600-1694]
- IPR009060: UBA-like superfamily (homologous_superfamily) [1341-1393]
- IPR050409: E3 ubiquitin-protein ligase (family) [227-4010]
- IPR015940: Ubiquitin-associated domain (domain) [1351-1390]
Interaction partners: - Polyubiquitin-like Protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin carboxyl-terminal hydrolase 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0006403 (RNA localization), GO:0051236 (establishment of RNA localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0050658 (RNA transport), GO:0071705 (nitrogen compound transport), GO:0015931 (nucleobase-containing compound transport), GO:0033227 (dsRNA transport), GO:0050657 (nucleic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)