Protein: Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) (A0A494C1K5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFRISSRIPYYIWPSYLHRLL
InterPro domains: - IPR006941: Ribonuclease CAF1 (family) [4-390]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [431-521]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [437-528]
- IPR051181: CAF1 family poly(A)-specific ribonucleases (family) [1-520]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [1-403]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [1-436]
- IPR014789: Poly(A)-specific ribonuclease, RNA-binding (domain) [437-514]
- IPR036867: R3H domain superfamily (homologous_superfamily) [170-255]
- IPR001374: R3H domain (domain) [178-245]
- IPR034042: PARN, R3H domain (domain) [181-246]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0043169 (cation binding), GO:0019899 (enzyme binding), GO:0004518 (nuclease activity), GO:0019900 (kinase binding), GO:0003723 (RNA binding), GO:0004540 (ribonuclease activity), GO:0070034 (telomerase RNA binding), GO:0004532 (exoribonuclease activity), GO:0003729 (mRNA binding), GO:0004527 (exonuclease activity), GO:0019901 (protein kinase binding), GO:0008408 (3'-5' exonuclease activity), GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters), GO:0016796 (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0003730 (mRNA 3'-UTR binding), GO:0000175 (3'-5'-RNA exonuclease activity), GO:0004535 (poly(A)-specific ribonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0009056 (catabolic process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0043487 (regulation of RNA stability), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process), GO:0031330 (negative regulation of cellular catabolic process), GO:0019439 (aromatic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0009057 (macromolecule catabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0007292 (female gamete generation), GO:0090304 (nucleic acid metabolic process), GO:0043489 (RNA stabilization), GO:0044265 (cellular macromolecule catabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:1901361 (organic cyclic compound catabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0051252 (regulation of RNA metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0031329 (regulation of cellular catabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0010638 (positive regulation of organelle organization), GO:0010467 (gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051972 (regulation of telomerase activity), GO:0016070 (RNA metabolic process), GO:0051347 (positive regulation of transferase activity), GO:0032204 (regulation of telomere maintenance), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0006401 (RNA catabolic process), GO:0006396 (RNA processing), GO:1902369 (negative regulation of RNA catabolic process), GO:0009451 (RNA modification), GO:2000573 (positive regulation of DNA biosynthetic process), GO:2001252 (positive regulation of chromosome organization), GO:0032206 (positive regulation of telomere maintenance), GO:2000278 (regulation of DNA biosynthetic process), GO:0033044 (regulation of chromosome organization), GO:0010608 (post-transcriptional regulation of gene expression), GO:0032210 (regulation of telomere maintenance via telomerase), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0034470 (ncRNA processing), GO:0031123 (RNA 3'-end processing), GO:0032212 (positive regulation of telomere maintenance via telomerase), GO:1904358 (positive regulation of telomere maintenance via telomere lengthening), GO:0034661 (ncRNA catabolic process), GO:0051973 (positive regulation of telomerase activity), GO:1904356 (regulation of telomere maintenance via telomere lengthening), GO:0034660 (ncRNA metabolic process), GO:0043144 (sno(s)RNA processing), GO:0010586 (miRNA metabolic process), GO:0016074 (sno(s)RNA metabolic process), GO:0090503 (RNA phosphodiester bond hydrolysis, exonucleolytic), GO:0043628 (regulatory ncRNA 3'-end processing), GO:0031126 (sno(s)RNA 3'-end processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005654 (nucleoplasm), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)