Protein: hypoxia-inducible factor-proline dioxygenase (R4SCQ0)
Organism: Homo sapiens (Human)
Subcellular location: Nucleus
Sequence: MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
InterPro domains: - IPR005123: Oxoglutarate/iron-dependent dioxygenase domain (domain) [291-392]
- IPR044862: Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain (domain) [299-390]
- IPR002893: Zinc finger, MYND-type (domain) [21-58]
- IPR051559: Hypoxia-inducible factor prolyl hydroxylases (family) [25-405]
- IPR006620: Prolyl 4-hydroxylase, alpha subunit (domain) [205-391]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0043169 (cation binding), GO:0031543 (peptidyl-proline dioxygenase activity), GO:0031545 (peptidyl-proline 4-dioxygenase activity), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0008198 (ferrous iron binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0055082 (intracellular chemical homeostasis), GO:0001666 (response to hypoxia), GO:0010035 (response to inorganic substance), GO:1901564 (organonitrogen compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0044092 (negative regulation of molecular function), GO:0070482 (response to oxygen levels), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0019538 (protein metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0036293 (response to decreased oxygen levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0071731 (response to nitric oxide), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:2001141 (regulation of RNA biosynthetic process), GO:0018126 (protein hydroxylation), GO:0006355 (regulation of DNA-templated transcription), GO:0018193 (peptidyl-amino acid modification), GO:0019511 (peptidyl-proline hydroxylation), GO:0018208 (peptidyl-proline modification), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)