Protein: 5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (ST-B17) (Serotonin receptor 6) (P31388)
Organism: Rattus norvegicus (Rat)
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P50406}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
InterPro domains: - IPR002232: 5-Hydroxytryptamine 6 receptor (family) [29-331]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [43-320]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [28-335]
Interaction partners: - Guanine nucleotide-binding protein G
- Basigin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0035295 (tube development), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0046887 (positive regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0060341 (regulation of cellular localization), GO:0010647 (positive regulation of cell communication), GO:0051222 (positive regulation of protein transport), GO:0010817 (regulation of hormone levels), GO:0046883 (regulation of hormone secretion), GO:1903532 (positive regulation of secretion by cell), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0007399 (nervous system development), GO:0090087 (regulation of peptide transport), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:0050714 (positive regulation of protein secretion), GO:0002791 (regulation of peptide secretion), GO:0032024 (positive regulation of insulin secretion), GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0050796 (regulation of insulin secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0043226 (organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium)