Protein: DNA replication licensing factor MCM5 (EC 3.6.4.12) (Q6NV07)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368063}.
Sequence: MSGFDDPGVYYSDSFGGGESVGDEGVVKRSQIKKKFREFLRQFRVGTDRTGFTYKYRDELKRHYTLGEYWIEVEMEDLASFDEDLSDCLYKLPSENLPLLEEAAQEVADEVTRPRPVGEETVQDIQVMLKSDAHPASIRSLKSEQVSRLVKIPGIIISSTAVRAKATRVCLQCRGCRAVISNIPLPPGLQGYALPRKCNTEQAGRVKCPVDPYFIIPDRCVCVDFQTQRLQEAPDAVPHGEMPRHMQLYCDRYLCDRVVPGNRVTVMGIYSIKKVAQTKAKGRDKGTGVGIRSAYLRVVGIDVDTEGAGRGATGSVSPQEEEELRSLAASPSVYDSLARSLAPSIYGSDDLKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVLRDPTTRGFVMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTKGEDNIDFMPTILSRFDMIFIIKDHHDQQRDMTLARHVMNVHLSAQTQTEGVEGEIPLATLKKYIAYSRVKCGPRLSAAAAEKLKNRYVLMRSGAKEHERETDRRVSIPITVRQLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVSTLDAALSGSLSGVEGFTTQEDQEMISRIEKQLKRRFAIGSQVSEHSIIQDFAKQKYPEHAIQKVLYLMLRRGELQHRMQRKVLYRVK
InterPro domains: - IPR054125: MCM5, C-terminal domain (domain) [676-734]
- IPR031327: Mini-chromosome maintenance protein (family) [29-707]
- IPR027925: MCM, N-terminal domain (domain) [33-130]
- IPR008048: DNA replication licensing factor Mcm5 (family) [139-661]
- IPR033762: MCM OB domain (domain) [138-272]
- IPR041562: MCM, AAA-lid domain (domain) [560-649]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [314-661]
- IPR018525: Mini-chromosome maintenance, conserved site (conserved_site) [442-450]
- IPR001208: MCM domain (domain) [321-542]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [40-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016887 (ATP hydrolysis activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0048872 (homeostasis of number of cells), GO:0072001 (renal system development), GO:0090304 (nucleic acid metabolic process), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0001822 (kidney development), GO:0006260 (DNA replication), GO:0001654 (eye development), GO:0006270 (DNA replication initiation), GO:0051276 (chromosome organization), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0098687 (chromosomal region), GO:0031974 (membrane-enclosed lumen), GO:0140513 (nuclear protein-containing complex), GO:0042555 (MCM complex), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0031261 (DNA replication preinitiation complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000781 (chromosome, telomeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0071162 (CMG complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)