Protein: Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)] (P9WHF1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Sequence: MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKLGHDLAGLDDFHESVHLPGEFGGAL
InterPro domains: - IPR016299: Riboflavin biosynthesis protein RibBA (family) [3-403]
- IPR032677: GTP cyclohydrolase II (domain) [210-381]
- IPR036144: GTP cyclohydrolase II superfamily (homologous_superfamily) [207-384]
- IPR017945: DHBP synthase RibB-like alpha/beta domain superfamily (homologous_superfamily) [5-208]
- IPR000422: 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB (family) [2-206]
- IPR000926: GTP cyclohydrolase II, RibA (family) [207-407]
Interaction partners: - 6,7-dimethyl-8-ribityllumazine synthase
- Riboflavin synthase
- Riboflavin biosynthesis protein RibD
- GTP cyclohydrolase 1
- 3,4-dihydroxy-2-butanone-4-phosphate synthase
- Bacterial bifunctional deaminase-reductase C-terminal domain-containing protein
- GTP 3',8-cyclase 1
- GTP 3',8-cyclase 2
- Nucleoside diphosphate kinase
- Uncharacterized protein Rv1417
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0042803 (protein homodimerization activity), GO:0046872 (metal ion binding), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0000287 (magnesium ion binding), GO:0019238 (cyclohydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006766 (vitamin metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0009110 (vitamin biosynthetic process), GO:0042726 (flavin-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0006771 (riboflavin metabolic process), GO:0042364 (water-soluble vitamin biosynthetic process), GO:0042727 (flavin-containing compound biosynthetic process), GO:0009231 (riboflavin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)