Protein: Fet99p (A0A1D8PPE6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane; Single-pass membrane protein
Sequence: MRFIVSSFIFFISFLSSLITAETHTWYFKTSWVDANPDGVFPRKMIGFNDSWPLPTLRAKKGDRIQLYLINGFEDLNTTLHFHGLFQHGTNQMDGPEMVTQCPIPPGETYLYNFTIDDQVGTYWYHSHTSGQYGDGMRGVFIIEDDDFPYDYDEEIVLTLSEHYHDYSKDLMPGFLSRFNPTGAEPIPSNILFNETRNNTWKVEPGKTYLLRIANTGRFVTQYLWMEDHEFTVVEVDGVYVEKNTTDMLYITIAQRYGVLITTKNSTDKNYAFMNRVDDTMLDTIPKDLQLNGTNYIVYNESAPLPDAYDVDSIDDYLDDFYLKPLNKEKLLDDADYTITVDVQMDNLGNGVNYAFFNNITYMTPKVPTLLNVLSAGDASTNELVYGSNTNSFVLQGGDVVDIVLNNLDTGRHPFHLHGHVFQLIERHEEIPDTEDPVSYNVSDHAEWPEYPMSRDTVYVKPQSYIVMRFKADNPGVWFFHCHIEWHLDQGLAIVLIEDPEAIQKNSSQHLTDNHKQICEKVGVSWEGNAAANSNNYLDLKGENIQVKRLPTGFTARGIVALVFSCIAAFLGIAAIAYYGMNDIEDVEERVARDLDVDLDEENEDEEEAEIVNEGSSSSGSNSKQH
InterPro domains: - IPR044130: Iron transport multicopper oxidase Fet3-like, the second Cupredoxin domain (domain) [154-301]
- IPR008972: Cupredoxin (homologous_superfamily) [16-537]
- IPR011707: Multicopper oxidase-like, N-terminal (domain) [31-146]
- IPR045087: Multicopper oxidase (family) [43-499]
- IPR001117: Multicopper oxidase, second cupredoxin domain (domain) [154-302]
- IPR011706: Multicopper oxidase, C-terminal (domain) [362-501]
- IPR033138: Multicopper oxidases, conserved site (conserved_site) [121-496]
- IPR002355: Multicopper oxidase, copper-binding site (binding_site) [481-492]
Interaction partners: - Fth1p
- Fth2p
- High-affinity iron permease
- Ftr2p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016722 (oxidoreductase activity, acting on metal ions), GO:0016724 (oxidoreductase activity, acting on metal ions, oxygen as acceptor), GO:0004322 (ferroxidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0044281 (small molecule metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0098660 (inorganic ion transmembrane transport), GO:0006082 (organic acid metabolic process), GO:0006810 (transport), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034220 (monoatomic ion transmembrane transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0006631 (fatty acid metabolic process), GO:0098662 (inorganic cation transmembrane transport), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0006811 (monoatomic ion transport), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0006812 (monoatomic cation transport), GO:0033559 (unsaturated fatty acid metabolic process), GO:0034755 (iron ion transmembrane transport), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0030001 (metal ion transport), GO:0032787 (monocarboxylic acid metabolic process), GO:0006690 (icosanoid metabolic process), GO:0046456 (icosanoid biosynthetic process), GO:0006636 (unsaturated fatty acid biosynthetic process), GO:0006692 (prostanoid metabolic process), GO:0006693 (prostaglandin metabolic process), GO:0000041 (transition metal ion transport), GO:0046457 (prostanoid biosynthetic process), GO:0001516 (prostaglandin biosynthetic process), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0005886 (plasma membrane)