wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Hemoglobin subunit gamma-1 (P69891)
Organism: Homo sapiens (Human)
Function: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
Sequence: MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFDSFGNLSSASAIMGNPKVKAHGKKVLTSLGDATKHLDDLKGTFAQLSELHCDKLHVDPENFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH
InterPro domains: - IPR050056: Hemoglobin and related oxygen transporters (family) [4-147]
- IPR012292: Globin/Protoglobin (homologous_superfamily) [3-147]
- IPR000971: Globin (domain) [3-147]
- IPR002337: Hemoglobin, beta-type (family) [8-146]
- IPR009050: Globin-like superfamily (homologous_superfamily) [3-147]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0015669 (gas transport), GO:0015671 (oxygen transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0072562 (blood microparticle), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005833 (hemoglobin complex), GO:0005615 (extracellular space)
Protein: Acid stress chaperone HdeA (P0AES9)
Organism: Escherichia coli (strain K12)
Function: Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non- specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
Subcellular location: Periplasm
Sequence: MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLAVDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGEWDKIKKDM
InterPro domains: - IPR010486: HNS-dependent expression A/B (family) [11-96]
- IPR024972: HNS-dependent expression A (family) [1-107]
- IPR036831: HNS-dependent expression A superfamily (homologous_superfamily) [30-108]
- IPR038303: HNS-dependent expression A/B superfamily (homologous_superfamily) [22-110]
Interaction partners: - Glutamate decarboxylase beta
- Glutamate decarboxylase beta
- Glutamate decarboxylase beta
- Acid stress chaperone HdeB
- Protein HdeD
- Glutamate/gamma-aminobutyrate antiporter
- Glutamate/gamma-aminobutyrate antiporter
- Glutamate decarboxylase alpha
- Transcriptional regulator GadE
- Outer membrane protein Slp
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044183 (protein folding chaperone), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0051087 (chaperone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009268 (response to pH), GO:0071214 (cellular response to abiotic stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0071467 (cellular response to pH), GO:0010447 (response to acidic pH), GO:0071468 (cellular response to acidic pH)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: Antitoxin HicB (P67697)
Organism: Escherichia coli (strain K12)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HicA-mediated cessation of cell growth and inhibition of cell proliferation
Sequence: MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKVLLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
InterPro domains: - IPR051404: Type II Toxin-Antitoxin System Antitoxin (family) [1-73]
- IPR010982: Lambda repressor-like, DNA-binding domain superfamily (homologous_superfamily) [82-136]
- IPR001387: Cro/C1-type, helix-turn-helix domain (domain) [81-136]
- IPR035069: Antitoxin HicB/UPF0150 (homologous_superfamily) [1-64]
- IPR031807: HicB-like antitoxin of toxin-antitoxin system (domain) [3-66]
Interaction partners: - Probable mRNA interferase toxin HicA
- Antitoxin HigA
- mRNA interferase toxin HigB
- Antitoxin MazE
- mRNA interferase toxin RelE
- Antitoxin RelB
- Antitoxin MqsA
- Endoribonuclease toxin MazF
- Antitoxin ChpS
- Antitoxin DinJ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex), GO:0017053 (transcription repressor complex), GO:0110001 (toxin-antitoxin complex)
Protein: Protein HIR1 (Q5ACW8)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle
Subcellular location: Nucleus
Sequence: MQILKIPWFGHKTENKTVECYAVTINKDGTRLASGGLDGNVKIWDLTTINVFYKMADQPHKSKKDSTSTKLEESLPDKSLRRPLCSMSRHNGVVTSLKFSPDGRWLASGSDDKICLIWEKDNTQIAKSFGTDEHDLEHWTVRKRLVAHDNDIQDICWSPDGNLLVTVGLDRSVIIWNALTFEKIKRYDIHQSMVKGIVFDPANKFFATASDDRTVRIFRYYKKLNEYNNYEFQMEHVVVDPFKKSPLTSYFRRMSWSPDGQHIAVPNATNGPVPSVAIINRGNWGSDISLIGHEAPVEVCSFSPTLFQIADTPANEEIKFQTVVATGGQDRTLAIWSTCNSRPIVVCSDIVDSSITDICWSPDGETLYFSCLDGSITGVKFGARELGQPVKEDLIDQQLNRYGADRESTILPESVEQLQLEEQSKDSRAISIRRMMPIQEAKPEQTPPISTPASAAIDIERLRKQTVTMTKSGKKRVAPLLVSTSAAPKNVLQKPLEKKRRTKSSSKISQAAYLLPKMGVQTTVHGIKKKAESMSNDTEVEENNDNDDIGENVMANTNSVSDAALKRQRNRRKRKLMELKYPSSFKYISNLPEGLFNNHTLQNIEINKIYKAHSKHKDISAEISSSTAVEIDEDLVFSVVFRVFDHMRKENEVLGQTSGRIRTTIEVRNGKPWDDDISDRDFDDATKVIVTEEGNDKREYCLFFPFRVQHVLPIILNDVLKYYVLCSFHGSVQIISADTGSYRCPTFELGESVVTMRHSQGYMLVLTSSGLFYSWDLKAMKVTMTGISIAAILNNYEIGGKIVVSPIVRGLEINPQDGSPLVLLDMTNDIYGYSIDLQCWVKTVDSWYYGVGADKDLDVVLTGLVKKSKMSYEEDKVTEKIFTYKFDSSNDLEDAMRKRGQELLDLI
InterPro domains: - IPR019015: HIRA B motif (conserved_site) [464-485]
- IPR031120: WD repeat HIR1-like (family) [1-848]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [20-381]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [6-438]
- IPR001680: WD40 repeat (repeat) [1-380]
- IPR055410: CAF1B/HIR1, beta-propeller domain (domain) [84-386]
- IPR019775: WD40 repeat, conserved site (conserved_site) [32-46]
- IPR011494: Protein HIRA-like, C-terminal (domain) [742-849]
Interaction partners: - Histone chaperone ASF1
- Protein HIR2
- Hpc2p
- Histone transcription regulator 3 homolog
- Histone H2A.Z-specific chaperone CHZ1
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0044877 (protein-containing complex binding), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0031491 (nucleosome binding), GO:0003714 (transcription corepressor activity), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0007059 (chromosome segregation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: Histidine biosynthesis bifunctional protein HisIE (P06989)
Organism: Escherichia coli (strain K12)
Subcellular location: Cytoplasm
Sequence: MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ
InterPro domains: - IPR021130: Phosphoribosyl-ATP pyrophosphohydrolase-like (family) [115-202]
- IPR002496: Phosphoribosyl-AMP cyclohydrolase domain (domain) [33-105]
- IPR023019: Histidine biosynthesis bifunctional protein HisIE (family) [8-203]
- IPR008179: Phosphoribosyl-ATP pyrophosphohydrolase (family) [112-198]
- IPR038019: Phosphoribosyl-AMP cyclohydrolase domain superfamily (homologous_superfamily) [2-122]
Interaction partners: - Histidinol-phosphate aminotransferase
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
- Histidine biosynthesis bifunctional protein HisB
- Imidazole glycerol phosphate synthase subunit HisF
- Histidinol dehydrogenase
- Imidazole glycerol phosphate synthase subunit HisH
- ATP phosphoribosyltransferase
- Tryptophan biosynthesis protein TrpCF
- Phosphoserine phosphatase
- Phosphatidylglycerophosphatase C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0016462 (pyrophosphatase activity), GO:0019238 (cyclohydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006547 (histidine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0000105 (histidine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: 5-hydroxyisourate hydrolase (P76341)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)
Subcellular location: Periplasm
Sequence: MLKRYLVLSVATAAFSLPSLVNAAQQNILSVHILNQQTGKPAADVTVTLEKKADNGWLQLNTAKTDKDGRIKALWPEQTATTGDYRVVFKTGDYFKKQNLESFFPEIPVEFHINKVNEHYHVPLLLSQYGYSTYRGS
InterPro domains: - IPR036817: Transthyretin/hydroxyisourate hydrolase domain superfamily (homologous_superfamily) [24-137]
- IPR014306: Hydroxyisourate hydrolase (family) [27-137]
- IPR023419: Transthyretin, conserved site (conserved_site) [120-132]
- IPR023418: Transthyretin, thyroxine binding site (binding_site) [32-47]
- IPR000895: Transthyretin/hydroxyisourate hydrolase (family) [28-137]
- IPR023416: Transthyretin/hydroxyisourate hydrolase domain (domain) [23-137]
Interaction partners: - Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ
- Protein-methionine-sulfoxide reductase catalytic subunit MsrP
- Transcriptional regulatory protein HprR
- Guanine deaminase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016812 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Gamma-hemolysin component B (Q2FVK1)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity. Promotes host AMFR-mediated inflammation by mediating 'Lys-27'-linked ubiquitination of TAB3, TAK1-TAB3 complex formation and phosphorylation of TAK1/MAP3K7. In turn, activates host NF-kappa-B signaling pathway
Subcellular location: Secreted
Sequence: MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
InterPro domains: - IPR036435: Leukocidin/porin MspA superfamily (homologous_superfamily) [28-324]
- IPR016183: Leukocidin/Hemolysin toxin (domain) [60-310]
- IPR003963: Bi-component toxin, staphylococci (family) [5-315]
Interaction partners: - Gamma-hemolysin component C
- Gamma-hemolysin h-gamma-ii subunit, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0001906 (cell killing), GO:0031640 (killing of cells of another organism)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0010033 (response to organic substance)
Protein: Transcription factor 12 (A0A0R4IBL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3') (By similarity). May be involved in the functional network that regulates the development of the GnRH axis
Subcellular location: Nucleus
Sequence: MNPQQRIAAIGTDKELSDLLDFSAMFSPPVNSGKNRPTTLGSSQFTASGMDERTSQASWASGGQSSPSFESSRGFADSHYADHLSDSRLVSHEGLSPTPFMSSSIMGKSERPPFSGYGREPGVSGCQSNLRSDIQLASPGPVTTPGKSPTPFYSYTGPNPRRRPLQDSASMDPLQTKKVRKPPPGLPTSVYAPSPSSEDFNRDSPSYPSPKPPGSMFASTFFDGTHNSSDQWNLSNGISQPGYGGMLGGSSSHMPQSGNYSNLHSHDRLNYPPHSVSPTDINASLPPMSSFHRSSASTSPFVTASHTPPVNTTEGVMAAANRGNATGSSQTGDALGKALASIYSPDHTSSSFPSNPSTPVGSPSPLAVQAGAATAGTVVTASGPAGRAGTTQWTRATGQAPSSPSYENSLHSLKNRVHQQLHEHLQDAMSFLKDVCESRMEDRLDRLDDAIHVLRNHAVGSTAALSNDIHSLLGQAHNGPISAIGSSFPSSGLVTNRTAQMGSVHREESGSLNNNNHSALQASAAPTSSSELNHQADAFRAIAGVLASQVASPLGLKVENQDKDDMHDSHASDDLKSDDESDKRDMKQNRGSSRPSCELSCSSINEDEDLNPEQKAERERERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVSGDPQQAHPAVHPGLTDTSNPMGHL
InterPro domains: - IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [607-688]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [621-680]
- IPR051098: Neuronal Differentiation E-box Binding Transcription Factors (family) [5-725]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0061061 (muscle structure development), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0051146 (striated muscle cell differentiation), GO:0055002 (striated muscle cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Hyphal wall protein 1 (P46593)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence factors and host inflammatory responses when protective immunity is absent
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI- anchor. Note=Hyphal surface. Localizes to the a/a Portion of the conjugation bridge during mating
Sequence: MRLSTAQLIAIAYYMLSIGATVPQVDGQGETEEALIQKRSYDYYQEPCDDYPQQQQQQEPCDYPQQQQQEEPCDYPQQQPQEPCDYPQQPQEPCDYPQQPQEPCDYPQQPQEPCDNPPQPDVPCDNPPQPDVPCDNPPQPDVPCDNPPQPDVPCDNPPQPDQPDDNPPIPNIPTDWIPNIPTDWIPDIPEKPTTPATTPNIPATTTTSESSSSSSSSSSSTTPKTSASTTPESSVPATTPNTSVPTTSSESTTPATSPESSVPVTSGSSILATTSESSSAPATTPNTSVPTTTTEAKSSSTPLTTTTEHDTTVVTVTSCSNSVCTESEVTTGVIVITSKDTIYTTYCPLTETTPVSTAPATETPTGTVSTSTEQSTTVITVTSCSESSCTESEVTTGVVVVTSEETVYTTFCPLTENTPGTDSTPEASIPPMETIPAGSEPSMPAGETSPAVPKSDVPATESAPVPEMTPAGSQPSIPAGETSPAVPKSDVSATESAPAPEMTPAGTETKPAAPKSSAPATEPSPVAPGTESAPAGPGASSSPKSSVLASETSPIAPGAETAPAGSSGAITIPESSAVVSTTEGAIPTTLESVPLMQPSANYSSVAPISTFEGAGNNMRLTFGAAIIGIAAFLI
InterPro domains: - IPR025928: Flocculin type 3 repeat (repeat) [311-415]
Interaction partners: - Agglutinin-like protein 3
- Extent of cell elongation protein 1
- Hyphally regulated cell wall protein 1
- Transcriptional regulatory protein UME6
- Transcriptional regulator NRG1
- Agglutinin-like protein 1
- Hypha-specific G1 cyclin-related protein 1
- Secreted aspartic protease 5
- Enhanced filamentous growth protein 1
- Secreted aspartic protease 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall), GO:1903561 (extracellular vesicle), GO:0030445 (yeast-form cell wall)
Protein: Hyphal wall protein 2 (Q59PF9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein required for mating efficiency, biofilm formation, adhesion, filamentous growth, and oxidative stress tolerance. Involved in normal disseminated infection in a mouse systemic candidiasis model
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor. Note=localizes to the cell wall of hyphae
Sequence: MRFATTQLATLACFILTAEATFPLRGLFNDAPVDVDLGVYHEESGNNKEQKVDGFNMSPNIKKRTNENNAANVVSTNGGLFITSTKELKTTVVVTSCFNNVCSETSITTPKTAVTATTSKHSTSKPTYTTTSKHSTSHSSTPASTSKHSTSTSTHPATSEHSTSKSTHATSSKHSTSKSSVSVTTSKHSTHDTTSKSFVTPPASSTTSEHTKHKSHKPSKTVVTLTSCSNNACSQSEITTGAIVVTDKETVYTTYCPLTDTETETESTTATTSKHSTHTTTSKHSSVESTSVTSSSKHSVSKSTDVTTSKHSSSESSHATTMKHSTSKHSTHATTSKHSTTESTSGITSKHSTHATSSKYSTVESSSSFASTSESSVPVSSSKSTTFESSISTTTSKHLTLKSSTPASTLEYSTSIPPAPATTSNSLSTKSTTLTTISRSSTSGSSVPNTTRESSTSTTTPNSSSSESKVSSAIPKYSSSEVSSSATTLKSYSTTHSIPTTLVYSSSTSLGFSVTEFRNLTTTSKSSLSTSTTELLTSGTTVRSSTSESSVTSATSIYTSSESTTSSESTTSIETPKSIASKSSSSVTLPKSSTFAWSTSTTTPESSPITLKLSTSKPPKPSATMESSASTTKNSSIQSTSEATTSGSSGVESSVLTATTKSSVPVTTSEWSSVVTTPKSSAPNTTLEHSTSASETSSGSVYTTFDQSTTVITVTSCSDNLCSKTEVTTGVTVITSDTTSYTTYCPLTGTTTVSSALESLVTANKSTSYVGATPIVSSVVSTTPIISSASTTPIISSASTTSVISSASTTSVISNAISNPVSTDVKPTTSSQGTKSTPVDTDSKSTSETTVMVYTTKSVTPTTVESISVAVSSAAQSSIAAISSYEGTGNNMKLSFGVVIAGVAAFAI
InterPro domains: - IPR025928: Flocculin type 3 repeat (repeat) [221-748]
Interaction partners: - Agglutinin-like protein 3
- Hyphally regulated cell wall protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0031589 (cell-substrate adhesion), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:0042710 (biofilm formation), GO:0043708 (cell adhesion involved in biofilm formation), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0009277 (fungal-type cell wall), GO:1903561 (extracellular vesicle), GO:0030445 (yeast-form cell wall)