Protein: Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] (P60709)
Organism: Homo sapiens (Human)
Function: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:29925947}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:17289661}.
Sequence: MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
InterPro domains: - IPR020902: Actin/actin-like conserved site (conserved_site) [104-116]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [3-375]
- IPR004000: Actin family (family) [3-375]
- IPR004001: Actin, conserved site (conserved_site) [53-364]
Interaction partners: - Profilin-3
- Actin-like protein 6A
- Profilin-1
- Actin, cytoplasmic 2
- Cofilin-1
- Profilin-4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
- Cofilin-2
- RuvB-like 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0007155 (cell adhesion), GO:0032879 (regulation of localization), GO:0071840 (cellular component organization or biogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0050817 (coagulation), GO:0006950 (response to stress), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0030168 (platelet activation), GO:0048729 (tissue morphogenesis), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009611 (response to wounding), GO:0001568 (blood vessel development), GO:0098609 (cell-cell adhesion), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0032970 (regulation of actin filament-based process), GO:1903036 (positive regulation of response to wounding), GO:0060249 (anatomical structure homeostasis), GO:2000147 (positive regulation of cell motility), GO:0044087 (regulation of cellular component biogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0050878 (regulation of body fluid levels), GO:0007596 (blood coagulation), GO:0009888 (tissue development), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0051128 (regulation of cellular component organization), GO:0035239 (tube morphogenesis), GO:1903034 (regulation of response to wounding), GO:0010810 (regulation of cell-substrate adhesion), GO:0034109 (homotypic cell-cell adhesion), GO:1901888 (regulation of cell junction assembly), GO:0001944 (vasculature development), GO:0070527 (platelet aggregation), GO:0032956 (regulation of actin cytoskeleton organization), GO:0010628 (positive regulation of gene expression), GO:0002009 (morphogenesis of an epithelium), GO:0001895 (retina homeostasis), GO:0030334 (regulation of cell migration), GO:0150116 (regulation of cell-substrate junction organization), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:1902903 (regulation of supramolecular fiber organization), GO:0042060 (wound healing), GO:0048514 (blood vessel morphogenesis), GO:0032231 (regulation of actin filament bundle assembly), GO:0072359 (circulatory system development), GO:0090303 (positive regulation of wound healing), GO:0030335 (positive regulation of cell migration), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0007599 (hemostasis), GO:0060429 (epithelium development), GO:0034330 (cell junction organization), GO:0051493 (regulation of cytoskeleton organization), GO:1902414 (protein localization to cell junction), GO:0001952 (regulation of cell-matrix adhesion), GO:0034329 (cell junction assembly), GO:0110020 (regulation of actomyosin structure organization), GO:0090109 (regulation of cell-substrate junction assembly), GO:0001738 (morphogenesis of a polarized epithelium), GO:0110053 (regulation of actin filament organization), GO:0051492 (regulation of stress fiber assembly), GO:0045216 (cell-cell junction organization), GO:0061041 (regulation of wound healing), GO:0150105 (protein localization to cell-cell junction), GO:0007043 (cell-cell junction assembly), GO:0120193 (tight junction organization), GO:0051893 (regulation of focal adhesion assembly), GO:0120192 (tight junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)