Protein: Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin] (P02458)
Organism: Homo sapiens (Human)
Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Sequence: MIRLGAPQTLVLLTLLVAAVLRCQGQDVQEAGSCVQDGQRYNDKDVWKPEPCRICVCDTGTVLCDDIICEDVKDCLSPEIPFGECCPICPTDLATASGQPGPKGQKGEPGDIKDIVGPKGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREKGPDPLQYMRADQAAGGLRQHDAEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPANVPKKNWWSSKSKEKKHIWFGETINGGFHFSYGDDNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSIAYLDEAAGNLKKALLIQGSNDVEIRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKTSRLPIIDIAPMDIGGPEQEFGVDIGPVCFL
InterPro domains: - IPR050149: Collagen superfamily (family) [888-1233]
- IPR000885: Fibrillar collagen, C-terminal (domain) [1252-1487]
- IPR008160: Collagen triple helix repeat (repeat) [117-1216]
- IPR001007: VWFC domain (domain) [32-90]
Interaction partners: - Collagen alpha-1
- Collagen alpha-2
- Transcription factor SOX-9
- CD44 antigen
- Collagen alpha-1
- Platelet glycoprotein VI
- Collagen alpha-2
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005201 (extracellular matrix structural constituent), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019838 (growth factor binding), GO:0019899 (enzyme binding), GO:0030020 (extracellular matrix structural constituent conferring tensile strength), GO:0002020 (protease binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0051094 (positive regulation of developmental process), GO:0032963 (collagen metabolic process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:2000145 (regulation of cell motility), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0010718 (positive regulation of epithelial to mesenchymal transition), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0001944 (vasculature development), GO:0042476 (odontogenesis), GO:0030111 (regulation of Wnt signaling pathway), GO:0043588 (skin development), GO:0030334 (regulation of cell migration), GO:0045229 (external encapsulating structure organization), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0007600 (sensory perception), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0001501 (skeletal system development), GO:0043062 (extracellular structure organization), GO:0072359 (circulatory system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0031214 (biomineral tissue development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0030335 (positive regulation of cell migration), GO:0051252 (regulation of RNA metabolic process), GO:0008104 (protein localization), GO:0010717 (regulation of epithelial to mesenchymal transition), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0097435 (supramolecular fiber organization), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0050953 (sensory perception of light stimulus), GO:0033365 (protein localization to organelle), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0048706 (embryonic skeletal system development), GO:0034505 (tooth mineralization), GO:0030198 (extracellular matrix organization), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0030199 (collagen fibril organization), GO:0050954 (sensory perception of mechanical stimulus), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0090263 (positive regulation of canonical Wnt signaling pathway), GO:0034504 (protein localization to nucleus), GO:0045893 (positive regulation of DNA-templated transcription), GO:0007601 (visual perception), GO:0007605 (sensory perception of sound), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005581 (collagen trimer), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0099080 (supramolecular complex), GO:0098644 (complex of collagen trimers), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043230 (extracellular organelle), GO:0099081 (supramolecular polymer), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0005583 (fibrillar collagen trimer), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0065010 (extracellular membrane-bounded organelle), GO:0098643 (banded collagen fibril), GO:0099512 (supramolecular fiber), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)