Protein: T-box transcription factor T-A (Brachyury protein homolog-A) (No tail protein A-A) (No tail protein-A) (Protein T homolog-A) (T-box protein ZfT-A) (Zf-T-A) (Q07998)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail formation. Required for the morphogenesis of Kupffer's vesicle and regulates left-right asymmetry.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201, ECO:0000269|PubMed:1295726, ECO:0000269|PubMed:7600949}.
Sequence: MSASSPDQRLDHLLSAVESEFQKGSEKGDASERDIKLSLEDAELWTKFKELTNEMIVTKTGRRMFPVLRASVTGLDPNAMYSVLLDFVAADNNRWKYVNGEWVPGGKPEPQSPSCVYIHPDSPNFGAHWMKAPVSFSKVKLSNKLNGGGQIMLNSLHKYEPRIHIVKVGGIQKMISSQSFPETQFIAVTAYQNEEITALKIKHNPFAKAFLDAKERSDHKEVPDHSTDNQQSGYSQLGGWFLPSNGPMGPSSSPPQFNGAPVHSSGSYCERYSSLRNHRAAPYPSHYSHRSTTTNNYMDNSSGSLASHDSWSALQIPNSSGMGTLAHTTNTTSNTSQYPSLWSVAGTTLTPSGSASGSITGGLTSQFLRGSSMSYSGLTSSLPVSSPSSMYDPGLSEVGVGDAQFESSIARLTASWAPVAQSY
InterPro domains: - IPR002070: Transcription factor, Brachyury (family) [12-284]
- IPR046360: T-box transcription factor, DNA-binding domain (domain) [34-217]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [34-215]
- IPR001699: T-box transcription factor (family) [6-386]
- IPR036960: T-box superfamily (homologous_superfamily) [33-223]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [44-136]
Interaction partners: - Homeobox protein goosecoid
- Notochord homeobox.
- Forkhead box protein A2
- Homeobox protein MIXL1
- SRY-box containing gene 17
- Chordin
- Bone morphogenetic protein 4.
- Nanog
- POU domain, class 5, transcription factor 1
- Fibroblast growth factor 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048736 (appendage development), GO:0009790 (embryo development), GO:0035107 (appendage morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0033333 (fin development), GO:0060173 (limb development), GO:0033334 (fin morphogenesis), GO:0035113 (embryonic appendage morphogenesis), GO:0035108 (limb morphogenesis), GO:0030326 (embryonic limb morphogenesis), GO:0035137 (hindlimb morphogenesis), GO:0035116 (embryonic hindlimb morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)