Protein: Kynurenine aminotransferase (EC 2.6.1.-) (EC 2.6.1.63) (EC 2.6.1.7) (AeKAT) (Q17CS8)
Organism: Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Also catalyzes the irreversible transamination of several amino acids including cysteine, tyrosine, glutamine, methionine, histidine and phenylalanine. Can use various keto-acids as the amino group acceptor.
Subcellular location: Mitochondrion {ECO:0000255}.
Sequence: MMFLRNHNSVGGAIRTAVVLQDLQFIVSNKSSALTGAVSSVHRQQIRTMSSTSNETMHNKFDLPKRYQGSTKSVWVEYIQLAAQYKPLNLGQGFPDYHAPKYALDALAAAANSPDPLANQYTRGFGHPRLVQALSKLYSQLVDRTINPMTEVLVTVGAYEALYATIQGHVDEGDEVIIIEPFFDCYEPMVKAAGGIPRFIPLKPNKTGGTISSADWVLDNNELEALFNEKTKMIIINTPHNPLGKVMDRAELEVVANLCKKWNVLCVSDEVYEHMVFEPFEHIRICTLPGMWERTITIGSAGKTFSLTGWKIGWAYGPEALLKNLQMVHQNCVYTCATPIQEAIAVGFETELKRLKSPECYFNSISGELMAKRDYMASFLAEVGMNPTVPQGGYFMVADWSSLDSKVDLTQETDARKDYRFTKWMTKSVGLQGIPPSAFYSEPNKHLGEDFVRYCFFKKDENLQKAAEILRKWKGSS
InterPro domains: - IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [101-357]
- IPR004839: Aminotransferase, class I/classII, large domain (domain) [87-469]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [61-473]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [75-470]
- IPR051326: Kynurenine--oxoglutarate transaminase (family) [63-475]
Interaction partners: - Aspartate aminotransferase
- Kynurenine 3-monooxygenase
- Kynurenine formamidase
- Aspartate aminotransferase
- 5-methyltetrahydrofolate:homocysteine methyltransferase
- thioredoxin-disulfide reductase
- Cystathionine beta-synthase
- Cystathionine beta-synthase
- Adenosylhomocysteinase
- Adenosylhomocysteinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0019842 (vitamin binding), GO:0043168 (anion binding), GO:0016769 (transferase activity, transferring nitrogenous groups), GO:0070279 (vitamin B6 binding), GO:0008483 (transaminase activity), GO:0030170 (pyridoxal phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0070189 (kynurenine metabolic process), GO:0042537 (benzene-containing compound metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006103 (2-oxoglutarate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)