Protein: Fibrocystin-L (Polycystic kidney and hepatic disease 1-like protein 1) (PKHD1-like protein 1) (Protein D86) (Q80ZA4)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, stereocilium membrane {ECO:0000269|PubMed:31444330}. Note=Predominantly located at the upper half of the stereocilia of inner ear outer hair cell. {ECO:0000269|PubMed:31444330}.
Sequence: MGHLWLSGTWFLFGLLWCAADSHKGSSETIPKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNTELGNHVQLVSSFQSITCDVEKDSSHSTQITCYTRAMPEDTYSVRVSVDGVPVAENNTCKGVASSWACSFSTKSFRTPTIRSITPLSGTPGTLITIKGRLFTDVYGSNTALSSNGRNVRILRIYIGGMPCELLIPHSDDLYGLKLDHANGDTGSVTCKTTGTYIGHHNVSFILDSDYGRSFPEKMTYFVSSLNKISMFQTYPEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILKATYPGGRGLKVEVWNNSRPAHLEDILEYNEHTPGYMGATWTDSASYVWPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSQTGRTEDKVRIAYYSGNANTYFSNSTQRSDEIHLQKGKEYYIEILLQEYTLSAFVDVGLYQYKNVFTEQQTGDALNEEQVIKSQSTVVPEVQIITLENWETADVTNEVQQVTVTSPCVGANSCSLSQYRFIYNMEKTVWLPADASDFTLKSALNDLWSIKPDSVQVTSKRDLQSYIYTITFVSTRGDFDLLGYEVFEGSNVTLSITEQTKGKPNLETFTLNWDGIASKPLTPESSEAEFQVAVEEMVSAKCPPEIAHLEEGFLVKYFRDYETDFELEHINRGQKTAETDAYCGRYSLKNPAVLFDSTDVKPNKSPYGDILLFPYNQLCLAYKGSLANFIDLKFKYQDSGKIIRSADVQFEYNFASGNKWTYTCIDLLDFLQTKYAGTSFSLQRITLQKSSEFQSIYVDAVYIGQTPTVSVLDDMPKRRPPALANKGIFLKHFQVNRTKLNGSAMTIQYSVTITSYNCSHNIPMMAVSFGQIITNETKNELVYRGNNWPGESKIRIQKIQEASPPISGSFDVQAYGHTLKGIPAAVPAADLQFALQSLEEIEQVSVNREGTCAGYSWSIRWTSPRGKQPLLQINDSNIIGEKANVTVTTIKEGGLFRQRIPGDMLRTLNQQPQVEVYVNGIPAKCSGDCGFTWDAMITPLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQNLEGEGSHFIYRSQISHVWPDSGSLAGGTLLTISGFGFSENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQVTAKDSFSYSCLQTPVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLPPGKHDIYVKVRNWGLASTRNKLNASILYILEVIHMFPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTLHSTGTVFRITNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPFLRGIGYRIFSVSSPGSVTYDDKGFTNGRQKSASGSFSYQFTSPGIYYYSSGYVDEAHSISLQGVINVFPAEARHIPLYLFVGNIEATYVPAGPAHLQLASTAAGCLATEPLCGLNDTRVKHSNKLFFELSNCISPSIINITPSTGTANELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIREIVTLIVYNLGTAINTLTKAFDRRFVLLPNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVPAQCQSNCSFSYLENIAPYVTGIFPNSIQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNLTISSPAVASVSPTSGSIAGGTTLMITGNGFSPGNTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAIIYPPLSFTYAMEDTPFLKRIIPNRGLPGTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHAGGIFPVTMLHKTKGSAVSSVAFEYPLSIQNIYPTQGSFGGGQTLTVTGMGFDPWNSTILVCNSECAVDKLRSNSTTLFCVIPPNNGKGHDQVCGVSVVNGKDSSHSTKLFTYTLSLTPLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNIKNIGLAKLENADFLYADVWSANSSWGGSPPPEEGSLAVITKGQIILLDQSTPILKMLLIQGGTLIFDEANIELQAENILITDGGVLQIGTEASPFQHRAVITLHGHLRSPELPVYGAKTLGVREGTLDLHGLPIPVVWTRLTHTANAGEWTLTVQEAVTWKAGDNIVIASTGHRHSQAENEKRTIASVSADGMHITLTKPLNYTHLGITTTLPDGTVFEARAEVGILTRNILIRGSDNVEWNDKIPSCPDGFDTGEFATQTCLQGKFGEEMGSDQFGGCIMLHAPLPGADMVTGRIEYVEVFHAGQSFRLGRYPIHWHLLGDLQFKSYVKGCAIHQSYNRAITIHNTHHLLVERNIIYDIKGGAFFIEDGIEHGNILQYNLAVFVQQSTSLLNDDVTPAAFWVTNPNNTIRHNAAAGGTHFGFWYRMNDHPDGPSFDRNICQKRIPLGEFFNNTVHSQGWFGLWIFEEYFPMQTGSCTSTVPVPAIFNSLTVWNCQKGAEWVNGGALQFHNFVMVNNNEAGIETKRILAPYVGGWGESNGAVIKNAKIVGHLDELGMGPTFCTSKGLVLPFSQGLTVSSVHFMNFDRHACVALGVTSITGVCNDRCGGWSAKFVGIRYFHAPNKGGFRWEHEAVLIDVDGSLTGHRGHTVVPHSSLLDPSHCTQEPAWSIGFPGSICDASVSFHRLAFNKPSPVSLLEKDVVLSDSFGTSIVPFQKKRLTHMSGWMALIPNANHINWYFKGVEHLTNISYTSTFYGFKEEDYVIISHNFTQNPDMFNVVDMRNGSANPLNWNSSKNGDWHLEANTSTLYYLVSGRSDLPQSQPISGTLDPGVKDVIINFQAYCCVLQDCFPVHPPSRKPIPRKRPAAYNLWSNESFWQSSPENNYTVPRPGANVIIPEGTWIVADVDIPPVERLIIWGVLEMEDKSEIGVAGPTYRRVVLNATYISVQGGRLIGGWEDNPFKGELQIVLRGNHSTPEWAFPDGPNQGAKVLGVFGELDLHGLPHSVYKTKLLETAEAGSKILSLVDAVDWQEGEDVVITTTSYDLHQTEIRRIAKILHGHKILILNDSLSYTHLAERQWISGTAQSYTLSADVGILSRNIKIVGDDYSVLSKDSFGARILVGSFTGNMMTFKGNARISNVEFHHSGQEGYRDSTDPRYAVTFLNLGQIQDHGLSYVRGCAFHHVFSPAIGVFGTDGVDIDDNIIYFTVGEGIRIWGDANRVRGNLVTLSVWPGTYQNRKDLSSTLWHAAIEINRGTNTVLQNNVVAGFGRVGYRIDGEPCSSQANSMENWFNNEAHGGLYGIYMNQDGLPGCSLIQGFTIWTCWDYGIYFQTTESVHIYNVTLVNNGMSIFSMVYMPPSVSHKISSKTVKIKNSLIVGSSPEFNCSDVLTNDSPDVELTSAHRSSRPPSGGRSGICWPTFASAHNMAPRKPHAGIMSYNAISGLLHVSDSTFVGFKDVCSGETNVIFITNPLNEDLQHPIHVKNVQLIDTIEQSKVFIHRPDISKVNPSDCVDMVCDAKRKSFLRDLDGSFLGNSGSVIPQAEYEWDGNSQLGIGDYRIPKAMLTYLNGSRIPVTEKAPHKGIIRDATCKYIPEWQSYQCSGMEYAMMVLESLDSDTETRRLSPVAIMSNGYVDLINGPQDHGWCAGYTCQRRLSLFHGIVALNKKYEVYFTGTSPQNLRLMLLNVEHNKAVLVGIFFSTLQRLDVYVNNSLVCPKNTAWNAQKKHCELERHLSTEQFLPNLGSTVPGENYFDRTYQMLYLFLKGTTPVEVHTATVIFVSFHLPVMTADEFFSSHNLVRNLALFLKIPSDKIRVSRIIGASLRKKRSTGHIMEFEIGAAPTQFLSNSTTGQMQLSELQEITDSLGQAVVLGKISTILGFNISSMSITSPIPQPTDSGWIKVTAQPVERSAFPVHYLALVSSLSVVAQPVAAQPGQPFPQQPSVKAVDPEGNCVSVGITSLTLKAILKDSNNNQVGGLSGNTTIPFSTCWANYTDLTPHRTGKNYKIEFVLDNTVRVDSRPFSLSAQSVPGGSGSSPGSGSSSSGHSKASSVGTPVQTLAVITACLVGRLLLLEVFMAAVFILNTTVGIN
InterPro domains: - IPR002909: IPT domain (domain) [30-2176]
- IPR011658: PA14 domain (domain) [338-489]
- IPR006626: Parallel beta-helix repeat (repeat) [398-3514]
- IPR052387: Fibrocystin (family) [16-4195]
- IPR055401: CEMIP, beta-helix domain (domain) [2435-3374]
- IPR011050: Pectin lyase fold/virulence factor (homologous_superfamily) [3254-3535]
- IPR008972: Cupredoxin (homologous_superfamily) [1403-1505]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [30-2179]
- IPR037524: PA14/GLEYA domain (domain) [337-492]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [32-2175]
- IPR019316: G8 domain (domain) [2183-3173]
- IPR012334: Pectin lyase fold (homologous_superfamily) [3261-3535]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0009888 (tissue development), GO:0001817 (regulation of cytokine production), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0006810 (transport), GO:0030097 (hemopoiesis), GO:0071702 (organic substance transport), GO:0010628 (positive regulation of gene expression), GO:0002521 (leukocyte differentiation), GO:0060429 (epithelium development), GO:0010468 (regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0002573 (myeloid leukocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0150063 (visual system development), GO:0042325 (regulation of phosphorylation), GO:0030851 (granulocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0016324 (apical plasma membrane), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0097730 (non-motile cilium), GO:0097731 (9+0 non-motile cilium)