Protein: Zw10 protein (Q8UUR2)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MSVSVTVISPQGEVCTMITKKYSEFLPGMQSAEELVARVDGLSRSVDLLRAGVENEVQRDLTVAVAEFTELKQQLEQDTLVLSILKKLQEFDTALKEYNTALLEKRYIEAAQQLEKARSSLKTLESRKGFELKILKALRTELTVQTQNMLYHLGEEWQKLAVWKLPPSKETIGPESVMHSELHLCTLPSKEEEIAGPPVASVLQAFAVLGELHTKLKTFGKLLLKYILKPLISYPFLQPFVEEQSDVVILKFKSEKPDLDHSSPVEVFDKIKFILEVLHKYLLNVPVEQCVEDKKECRVTLAELLGDMMWEELSDCLIQNCLVNSIPTNSSKLEQYIEVIKSTEEFEKALKKMQFLKGDTTDLLKYARNVNSHFANKKCQDVIVAARNLMTSEIHNTVKITPDSSVALPKLPDPGSGDHVKMQKTSKLPNEMVNLENDSKLSQYTFSLPTCRISASVEKLMELAYQTLLETTASTDQCCIQLFYSVRNIFQLFYDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHLLTMGHQFRYRLTNILCDGACYLVDLEPGYRRLGMECFLAQMRVQKGEILERLSSARNFSNMDDEENYSAANKAIRQVLHQLKRLGKVWQDVLPVNVYCKAMGTLLNTALSEIVTRIAALEDISAEDADRLYSLCRIMVEEGPQVFTPLPEEDKNKKYQEEVPVYVQKWTTFKELMIILQANLQEIVDQWADGKGPLAAEFSPAEVKSLIRALFQNTERRAAALAKIK
InterPro domains: - IPR048343: Centromere/kinetochore protein zw10, C-terminal domain (domain) [446-576]
- IPR009361: Centromere/kinetochore protein zw10, N-terminal (domain) [11-95]
- IPR048344: Centromere/kinetochore protein zw10, middle domain (domain) [153-390]
- IPR055148: ZW10, C-terminal helical domain (domain) [598-752]
- IPR046362: Zw10/DSL1, C-terminal (homologous_superfamily) [555-753]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0042162 (telomeric DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051726 (regulation of cell cycle), GO:1903047 (mitotic cell cycle process), GO:0051129 (negative regulation of cellular component organization), GO:0035556 (intracellular signal transduction), GO:0045786 (negative regulation of cell cycle), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0010639 (negative regulation of organelle organization), GO:0051983 (regulation of chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0000075 (cell cycle checkpoint signaling), GO:0045839 (negative regulation of mitotic nuclear division), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:1905819 (negative regulation of chromosome separation), GO:0033043 (regulation of organelle organization), GO:1905818 (regulation of chromosome separation), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0051985 (negative regulation of chromosome segregation), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902099 (regulation of metaphase/anaphase transition of cell cycle), GO:0033048 (negative regulation of mitotic sister chromatid segregation), GO:0051783 (regulation of nuclear division), GO:0031577 (spindle checkpoint signaling), GO:0051784 (negative regulation of nuclear division), GO:0010965 (regulation of mitotic sister chromatid separation), GO:0045841 (negative regulation of mitotic metaphase/anaphase transition), GO:0033047 (regulation of mitotic sister chromatid segregation), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0033045 (regulation of sister chromatid segregation), GO:1902100 (negative regulation of metaphase/anaphase transition of cell cycle), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:2000816 (negative regulation of mitotic sister chromatid separation), GO:0033046 (negative regulation of sister chromatid segregation), GO:2001251 (negative regulation of chromosome organization), GO:0033044 (regulation of chromosome organization), GO:0071174 (mitotic spindle checkpoint signaling), GO:0071173 (spindle assembly checkpoint signaling), GO:0030071 (regulation of mitotic metaphase/anaphase transition), GO:0007094 (mitotic spindle assembly checkpoint signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)