Protein: Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Q6P689)
Organism: Rattus norvegicus (Rat)
Function: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T9L3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T9L3}. Cell membrane {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q5T9L3}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVSYVAAKCVDVRKNHHKTRWLMPWGPNKCNKINDFEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQIDIAFKLNNQIRENAEVSMDVSLGYRDDMFSEWTEMAHERVPRKLRCTFTSPKTPEHEGRHYECDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE
InterPro domains: - IPR009551: Protein wntless (family) [1-541]
- IPR053936: Wntless, GOLD domain (domain) [49-226]
- IPR047843: Wntless-like, transmembrane domain (domain) [227-496]
Interaction partners: - Protein Wnt
- Sorting nexin-3
- Protein Wnt
- Protein Wnt
- Protein Wnt
- Protein Wnt-5a
- Protein Wnt-4
- Protein Wnt
- Vacuolar protein sorting-associated protein 35
- Protein Wnt
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0017147 (Wnt-protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051050 (positive regulation of transport), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0035556 (intracellular signal transduction), GO:0010646 (regulation of cell communication), GO:0060341 (regulation of cellular localization), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0051222 (positive regulation of protein transport), GO:1903532 (positive regulation of secretion by cell), GO:0051223 (regulation of protein transport), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0051046 (regulation of secretion), GO:1902533 (positive regulation of intracellular signal transduction), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:0050714 (positive regulation of protein secretion), GO:1902531 (regulation of intracellular signal transduction), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0002791 (regulation of peptide secretion), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0032008 (positive regulation of TOR signaling), GO:0051057 (positive regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031984 (organelle subcompartment), GO:0098794 (postsynapse), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043230 (extracellular organelle), GO:0030133 (transport vesicle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0045211 (postsynaptic membrane), GO:0005794 (Golgi apparatus), GO:0042734 (presynaptic membrane), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0070062 (extracellular exosome), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0030658 (transport vesicle membrane), GO:0099634 (postsynaptic specialization membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0070382 (exocytic vesicle), GO:0065010 (extracellular membrane-bounded organelle), GO:0098984 (neuron to neuron synapse), GO:0005789 (endoplasmic reticulum membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane), GO:0097708 (intracellular vesicle), GO:0099501 (exocytic vesicle membrane)