Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (H3BUD0)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: XAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNSIEERRIHQESELHSYLSRLIAAERERELEECQRNHEGDEDDSHVRAQQACIEAKHDKYMADMDELFSQVDEKRKKRDIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQVRPAAGGAGPVAWSWAP
InterPro domains: - IPR041312: CHIP, N-terminal tetratricopeptide repeat domain (domain) [48-131]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [132-178]
- IPR003613: U-box domain (domain) [132-185]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060090 (molecular adaptor activity), GO:0016740 (transferase activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0031072 (heat shock protein binding), GO:0005102 (signaling receptor binding), GO:0051087 (chaperone binding), GO:0046332 (SMAD binding), GO:0046983 (protein dimerization activity), GO:0019787 (ubiquitin-like protein transferase activity), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0051787 (misfolded protein binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0044389 (ubiquitin-like protein ligase binding), GO:0051879 (Hsp90 protein binding), GO:0042803 (protein homodimerization activity), GO:0019900 (kinase binding), GO:0030544 (Hsp70 protein binding), GO:0001664 (G protein-coupled receptor binding), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity), GO:0031625 (ubiquitin protein ligase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0031647 (regulation of protein stability), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0046907 (intracellular transport), GO:0031325 (positive regulation of cellular metabolic process), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0071705 (nitrogen compound transport), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0051246 (regulation of protein metabolic process), GO:0010256 (endomembrane system organization), GO:0072594 (establishment of protein localization to organelle), GO:0030163 (protein catabolic process), GO:0071702 (organic substance transport), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0044265 (cellular macromolecule catabolic process), GO:0015031 (protein transport), GO:0051247 (positive regulation of protein metabolic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0033365 (protein localization to organelle), GO:0031399 (regulation of protein modification process), GO:0006998 (nuclear envelope organization), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0007029 (endoplasmic reticulum organization), GO:0006605 (protein targeting), GO:0007030 (Golgi organization), GO:0006626 (protein targeting to mitochondrion), GO:0031401 (positive regulation of protein modification process), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:0070972 (protein localization to endoplasmic reticulum), GO:0032446 (protein modification by small protein conjugation), GO:0019941 (modification-dependent protein catabolic process), GO:0031396 (regulation of protein ubiquitination), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0016567 (protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)