Protein: Vesicle-associated membrane protein-associated protein A (A8KA83)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell junction, tight junction {ECO:0000256|ARBA:ARBA00004435}. Cell membrane {ECO:0000256|ARBA:ARBA00004521}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004521}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004163}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004163}.
Sequence: MAKHEQILVLDPPTDLKFKGPFTDVVTTNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGSTVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPPNTSDMEAVWKEAKPDELMDSKLRCVFEMPNENDKLNDMEPSKAVPLNASKQDGPMPKPHSVSLNDTETRKLMEECKRLQGEMMKLSEENRHLRDEGLRLRKVAHSDKPGSTSTASFRDNVTSPLPSLLVVIAAIFIGFFLGKFIL
InterPro domains: - IPR000535: Major sperm protein (MSP) domain (domain) [7-124]
- IPR008962: PapD-like superfamily (homologous_superfamily) [2-130]
- IPR016763: Vesicle-associated membrane-protein-associated protein (family) [1-242]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-128]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0050839 (cell adhesion molecule binding), GO:0008092 (cytoskeletal protein binding), GO:0046983 (protein dimerization activity), GO:0045296 (cadherin binding), GO:0046982 (protein heterodimerization activity), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0019076 (viral release from host cell), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0044827 (modulation by host of viral genome replication), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051702 (biological process involved in interaction with symbiont), GO:0048731 (system development), GO:0019637 (organophosphate metabolic process), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006793 (phosphorus metabolic process), GO:0010876 (lipid localization), GO:0051701 (biological process involved in interaction with host), GO:0006629 (lipid metabolic process), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0043603 (amide metabolic process), GO:0030030 (cell projection organization), GO:0071705 (nitrogen compound transport), GO:0006644 (phospholipid metabolic process), GO:0044000 (movement in host), GO:0043604 (amide biosynthetic process), GO:0071702 (organic substance transport), GO:0006796 (phosphate-containing compound metabolic process), GO:0048666 (neuron development), GO:0006665 (sphingolipid metabolic process), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:1901566 (organonitrogen compound biosynthetic process), GO:0051851 (modulation by host of symbiont process), GO:0006869 (lipid transport), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0006643 (membrane lipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:1902533 (positive regulation of intracellular signal transduction), GO:0008104 (protein localization), GO:0046467 (membrane lipid biosynthetic process), GO:0006996 (organelle organization), GO:0008610 (lipid biosynthetic process), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0006684 (sphingomyelin metabolic process), GO:0061024 (membrane organization), GO:0006900 (vesicle budding from membrane), GO:0015914 (phospholipid transport), GO:0015850 (organic hydroxy compound transport), GO:0033365 (protein localization to organelle), GO:0015748 (organophosphate ester transport), GO:0016050 (vesicle organization), GO:0030148 (sphingolipid biosynthetic process), GO:0120036 (plasma membrane bounded cell projection organization), GO:0015918 (sterol transport), GO:0048193 (Golgi vesicle transport), GO:0008654 (phospholipid biosynthetic process), GO:0042886 (amide transport), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0090114 (COPII-coated vesicle budding), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0035891 (exit from host cell), GO:0035627 (ceramide transport), GO:0061025 (membrane fusion), GO:0044788 (modulation by host of viral process), GO:0070972 (protein localization to endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0031984 (organelle subcompartment), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005773 (vacuole), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030667 (secretory granule membrane), GO:0005789 (endoplasmic reticulum membrane), GO:0005774 (vacuolar membrane), GO:0042582 (azurophil granule), GO:0031982 (vesicle), GO:0005911 (cell-cell junction), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0043296 (apical junction complex), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0035577 (azurophil granule membrane), GO:0070160 (tight junction), GO:0098852 (lytic vacuole membrane), GO:0005766 (primary lysosome), GO:0005923 (bicellular tight junction), GO:0005765 (lysosomal membrane)