Protein: Protein jagged-1a (Q90Y57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions
Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane
Sequence: MILRPSATFAALSAHVLLRCLWMRVCEASGHFEMQVLSMQNVNGELQSGACCDGARDPAERSCAADQCDTFFRVCLKEYQSRVSSGGPCSYGSGSTPVIGGNTFSVKPLDQTNDKTRIVLPFSFAWPRSYTLIVEALDFNNDSSTGSINGQVIEKAVQSGMINPNRQWQVLKHNGPVAQFQYQIRVTCDEHYFGFGCNKFCRPRDDFFGHYTCDHNGNKTCLEGWAGPECNTAICKQGCSIEHGSCKVPGNCRCLYGWQGEYCDQCIPHPGCVHGTCIEPWQCLCDTNWGGQLCDKDLNTCGTLQPCLNGGTCSNTGPDKYHCACPDGYSGQNCERADNACLSEPCLNGGLCVESSLGFECQCAAGWTGPSCNINEDDCSPNPCNHSGVCVDLVDGFKCICPVQWTGKTCLIDANECEESPCVNAHSCRNLIGGYFCECLPGWTGQNCDINVNDCHGQCLNGGLCKDLVNGYRCVCAAGFAGDRCERDVDECASRPCLNGGRCQDTLNGFQCLCPPGFSGATCQLDLDYCESGPCQNGAQCFSLASDYYCKCPEDYEGKNCSQLKDHCLITPCQVIDSCTVAVVSNSTPGGLRLISSSVCGPHGRCRSHSHAGGHFSCDCQDGFTGTYCHENINDCESSPCLSGGTCIDKINAYQCICADGWEGPNCETNIDDCRTNPCRDRGVCRDLVNDFYCECENGWKGKTCHSRESQCDEDTCNNGGTCSDEGDSFKCLCSPGWEGATCNIAKNSSCLPNPCENGATCVVTGDGFTCVCKEGWEGPTCSQNSNDCNPQPCYNSGTCVDGDNWYRCECASGFAGPDCRININECQSSPCAFGSTCVDEINGYRCLCPPGRTGPRCQEVTGRPCVIGGRIAVDGAKWAEDCNTCYCHKGIVTCTKLFCGPKACRMLGSGRGDCPTGQLCVPVRDEQCFVKPCSSQGECWSAHRPAVRTHCQPDSHCANVTFTFNKDTMPQGVTVEQVCRELRHLYVTKNVTSEFSISVSCELSSAASNEIHVAIHVTENGIHGRVPVKEITDNIIDLVSKHSANSSVIGSIAEVRVQRKQPQNPNVDYMVPLLVSVVTAIWVLALASVFLWCIRHHRKQSSSATAINPTSPFSTPEENTANNAREHLNQIKNHIEKNASNGSLPGKELHCDDKNTVNAKIRTQFPESDASRRLQKTRFPHQPAYMLVDRDDRLSSNGTDIKKHPQWTNKRDNRDLESQHRVPDSQHRDSQHSLQKMEYIV
InterPro domains: - IPR000742: EGF-like domain (domain) [231-859]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [488-847]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [390-849]
- IPR056986: Protein jagged-1/2, predicted ferredoxin-like domain (domain) [952-1059]
- IPR001774: Delta/Serrate/lag-2 (DSL) protein (domain) [168-232]
- IPR026219: Jagged/Serrate protein (family) [927-1093]
- IPR001881: EGF-like calcium-binding domain (domain) [297-859]
- IPR013032: EGF-like, conserved site (conserved_site) [717-852]
- IPR011651: Notch ligand, N-terminal domain (domain) [29-186]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [341-789]
- IPR001007: VWFC domain (domain) [866-934]
Interaction partners: - Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 2 precursor
- Hairy/enhancer-of-split related with YRPW motif protein 1
- Protein jagged-1b
- Hairy/enhancer-of-split related with YRPW motif protein 2
- Transcription factor HES-5
- Catenin beta-1
- Vascular endothelial growth factor receptor kdr-like
- E3 ubiquitin-protein ligase mib1
- NUMB-like endocytic adaptor protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0005112 (Notch binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0035270 (endocrine system development), GO:0048863 (stem cell differentiation), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030878 (thyroid gland development), GO:0060218 (hematopoietic stem cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)