Protein: long-chain-fatty-acid--CoA ligase (A5WV16)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MLPQCERARSISGRPEGPYRAVESIDALVTQGFEGVDTLDKLFVHAVKSFNQAPCLGTREVLSEEEEKQPNGKIFKKLVLGNYSWMSYEAVDQAVESFGSGLAALGQKPRQTIAIFCETRAEWMIAAQACFRRNYPLVTLYATLGEDAVAYGLNQCGATHLITSTELLQSKLKNVLFAVSGLQHVIYVGSGEVHQADYPQSLIIHSMQEVTELGAKPENLSVEYERPSASDLAVVMYTSGSTGNPKGVKMQHSNLIAGMAGQCQRIPGLGSQDTIVSYLPLAHVLELTAEISCLSHGCRLGYSSPHTLTDQSSKIKKGSKGDCSVLKPTLIAAVPEIMDRICKNVNGKLQEMSVIKRTLFKLGFDYKLQQVSKGADSPMCDMLFFKQVNVLLGGCVRRMLSGGAPLSASTQRFMNVCFCPIAVGYGLTETCGAGTISDSSDYSTGRVGAPLICSEIKLRDWPEGGYTSQDKPHPRGEILIGGPNVAMGYYGSEGEGQNDNFWVDEAGQRWFSTGDIGEVHPDGCLEIVDRKKDLVKLQAGEYVSLGKVEAAMKNSPLIDNICVYASSDQNYVISFVVPNQKNLTELAKKSGIDGEWDDICNHTMMEEEVLKVIKEIAVTSKLERFEVPQKIRLSSEPWTPETGLVTDAFKLKRKELKNHYMKDIERLYGAK
InterPro domains: - IPR000873: AMP-dependent synthetase/ligase domain (domain) [77-490]
- IPR020845: AMP-binding, conserved site (conserved_site) [235-246]
- IPR042099: ANL, N-terminal domain (homologous_superfamily) [36-530]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [532-664]
Interaction partners: - Fatty acid synthase
- Monoglyceride lipase
- Beta-alanine-activating enzyme
- carnitine O-palmitoyltransferase
- Long-chain-fatty-acid--CoA ligase ACSBG1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0015645 (fatty acid ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0004467 (long-chain fatty acid-CoA ligase activity), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009967 (positive regulation of signal transduction), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0009953 (dorsal/ventral pattern formation), GO:0030510 (regulation of BMP signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0051896 (regulation of protein kinase B signaling), GO:0030513 (positive regulation of BMP signaling pathway), GO:0032872 (regulation of stress-activated MAPK cascade), GO:1900744 (regulation of p38MAPK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)