Protein: Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365) (Q96D42)
Organism: Homo sapiens (Human)
Function: Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair.
Subcellular location: Cell membrane {ECO:0000269|PubMed:29742433}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MHPQVVILSLILHLADSVAGSVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPMTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKGIYAGVCISVLVLLALLGVIIAKKYFFKKEVQQLSVSFSSLQIKALQNAVEKEVQAEDNIYIENSLYATD
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [24-110]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [27-124]
- IPR007110: Immunoglobulin-like domain (domain) [3-121]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [21-127]
- IPR003599: Immunoglobulin domain subtype (domain) [21-121]
- IPR052331: T-cell immunoglobulin and mucin domain-containing protein (family) [1-210]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [103-109]
Interaction partners: - Neutrophil gelatinase-associated lipocalin
- Cystatin-C
- Fatty acid-binding protein, liver
- T-cell immunoglobulin and mucin domain-containing protein 4
- Protein O-GlcNAcase
- Interleukin-18
- Osteopontin
- Insulin-like growth factor-binding protein 7
- Trefoil factor 3
- Albumin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0072341 (modified amino acid binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0001786 (phosphatidylserine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044085 (cellular component biogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0051668 (localization within membrane), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0045184 (establishment of protein localization), GO:0009991 (response to extracellular stimulus), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0071417 (cellular response to organonitrogen compound), GO:0071705 (nitrogen compound transport), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0072594 (establishment of protein localization to organelle), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0006886 (intracellular protein transport), GO:0010243 (response to organonitrogen compound), GO:0015031 (protein transport), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0031670 (cellular response to nutrient), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0031669 (cellular response to nutrient levels), GO:0071363 (cellular response to growth factor stimulus), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0072657 (protein localization to membrane), GO:0033365 (protein localization to organelle), GO:0036315 (cellular response to sterol), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0033365 (protein localization to organelle), GO:0006897 (endocytosis), GO:0071383 (cellular response to steroid hormone stimulus), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0072659 (protein localization to plasma membrane), GO:0071295 (cellular response to vitamin), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0034504 (protein localization to nucleus), GO:0045893 (positive regulation of DNA-templated transcription), GO:0051259 (protein complex oligomerization), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0051260 (protein homooligomerization), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0051262 (protein tetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098862 (cluster of actin-based cell projections), GO:0009986 (cell surface), GO:0005903 (brush border)