Protein: Paired mesoderm homeobox protein 1 (Homeobox protein K-2) (Muscle homeobox protein) (MHox) (Paired-related homeobox protein 1) (PRX-1) (P63013)
Organism: Mus musculus (Mouse)
Function: Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.
Subcellular location: Nucleus {ECO:0000269|PubMed:35589735}.
Sequence: MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
InterPro domains: - IPR001356: Homeodomain (domain) [92-156]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [90-157]
- IPR003654: OAR domain (domain) [219-235]
- IPR017970: Homeobox, conserved site (conserved_site) [127-150]
- IPR043378: Paired mesoderm homeobox protein 1/2 (family) [3-245]
Interaction partners: - Twist-related protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0001216 (DNA-binding transcription activator activity), GO:0003676 (nucleic acid binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0140297 (DNA-binding transcription factor binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0002520 (immune system development), GO:0008283 (cell population proliferation), GO:0007389 (pattern specification process), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0002520 (immune system development), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0048736 (appendage development), GO:0048729 (tissue morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0001974 (blood vessel remodeling), GO:0009799 (specification of symmetry), GO:0035107 (appendage morphogenesis), GO:0048534 (hematopoietic or lymphoid organ development), GO:0003013 (circulatory system process), GO:0003012 (muscle system process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0050673 (epithelial cell proliferation), GO:0009790 (embryo development), GO:0048534 (hematopoietic or lymphoid organ development), GO:0035239 (tube morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0055123 (digestive system development), GO:0008015 (blood circulation), GO:0048562 (embryonic organ morphogenesis), GO:0006936 (muscle contraction), GO:0048732 (gland development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0048536 (spleen development), GO:0048546 (digestive tract morphogenesis), GO:0048565 (digestive tract development), GO:0048538 (thymus development), GO:1903522 (regulation of blood circulation), GO:0030855 (epithelial cell differentiation), GO:0009855 (determination of bilateral symmetry), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0003015 (heart process), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0060429 (epithelium development), GO:0048565 (digestive tract development), GO:0007507 (heart development), GO:0060541 (respiratory system development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0048566 (embryonic digestive tract development), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0060047 (heart contraction), GO:0001947 (heart looping), GO:0030859 (polarized epithelial cell differentiation), GO:0006941 (striated muscle contraction), GO:0008016 (regulation of heart contraction), GO:0055007 (cardiac muscle cell differentiation), GO:0086003 (cardiac muscle cell contraction), GO:0061337 (cardiac conduction), GO:0060048 (cardiac muscle contraction), GO:0003161 (cardiac conduction system development), GO:0086002 (cardiac muscle cell action potential involved in contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)