Protein: Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) (O15198)
Organism: Homo sapiens (Human)
Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). {ECO:0000250}.
Sequence: MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQPVDATADRHVVLSIPNGDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
InterPro domains: - IPR003619: MAD homology 1, Dwarfin-type (domain) [29-138]
- IPR017855: SMAD-like domain superfamily (homologous_superfamily) [264-467]
- IPR013019: MAD homology, MH1 (domain) [16-140]
- IPR036578: SMAD MH1 domain superfamily (homologous_superfamily) [13-136]
- IPR001132: SMAD domain, Dwarfin-type (domain) [271-467]
- IPR013790: Dwarfin (family) [7-467]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [261-458]
Interaction partners: - Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 5
- Bone morphogenetic protein receptor type-2
- Mothers against decapentaplegic homolog 3
- Activin receptor type-1
- Bone morphogenetic protein receptor type-1A
- Bone morphogenetic protein receptor type-1B
- Mothers against decapentaplegic homolog 7
- Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0017151 (DEAD/H-box RNA helicase binding), GO:0031625 (ubiquitin protein ligase binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0001503 (ossification), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:1901576 (organic substance biosynthetic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0001649 (osteoblast differentiation), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:1904018 (positive regulation of vasculature development), GO:1901360 (organic cyclic compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0071559 (response to transforming growth factor beta), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0071772 (response to BMP), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0060395 (SMAD protein signal transduction), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0045765 (regulation of angiogenesis), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0071363 (cellular response to growth factor stimulus), GO:0010629 (negative regulation of gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0016070 (RNA metabolic process), GO:1903670 (regulation of sprouting angiogenesis), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0031047 (RNA-mediated gene silencing), GO:0006355 (regulation of DNA-templated transcription), GO:0006396 (RNA processing), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0071773 (cellular response to BMP stimulus), GO:1903672 (positive regulation of sprouting angiogenesis), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0034470 (ncRNA processing), GO:0045893 (positive regulation of DNA-templated transcription), GO:0070918 (regulatory ncRNA processing), GO:0030509 (BMP signaling pathway), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0007179 (transforming growth factor beta receptor signaling pathway), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0034660 (ncRNA metabolic process), GO:0035196 (miRNA processing), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0031053 (primary miRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)