Protein: Stress-activated protein kinase JNK (D6RCB1)
Organism: Homo sapiens (Human)
Function: Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity
Subcellular location: Cytoplasm
Sequence: MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENGE
InterPro domains: - IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [99-201]
- IPR008351: Mitogen-activated protein (MAP) kinase, JNK (family) [114-245]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [185-197]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [52-241]
- IPR000719: Protein kinase domain (domain) [64-245]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [62-241]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0040017 (positive regulation of locomotion), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:1901564 (organonitrogen compound metabolic process), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0019538 (protein metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0051247 (positive regulation of protein metabolic process), GO:0030335 (positive regulation of cell migration), GO:0006796 (phosphate-containing compound metabolic process), GO:0030334 (regulation of cell migration), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0019220 (regulation of phosphate metabolic process), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0043066 (negative regulation of apoptotic process), GO:0006468 (protein phosphorylation), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)