Protein: Galectin-9B (Gal-9B) (Galectin-9-like protein A) (Q3B8N2)
Organism: Homo sapiens (Human)
Function: Binds galactosides.
Sequence: MAFSGSQAPYLSPAVPFSGTIQGGLQDGFQITVNGAVLSSSGTRFAVDFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQKGRWGPEERKMHMPFQKGMPFDLCFLVQSSDFKVMVNGSLFVQYFHRVPFHRVDTISVNGSVQLSYISFQNPRTVPVQPAFSTVPFSQPVCFPPRPRGRRQKPPSVRPANPAPITQTVIHTVQSASGQMFSQTPAIPPMMYPHPAYPMPFITTIPGGLYPSKSIILSGTVLPSAQRFHINLCSGSHIAFHMNPRFDENAVVRNTQINNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHVFEYYHRLRNLPTINKLEVGGDIQLTHVQT
InterPro domains: - IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [9-355]
- IPR001079: Galectin, carbohydrate recognition domain (domain) [15-356]
- IPR044156: Galectin-like (family) [208-355]
Interaction partners: - Hepatitis A virus cellular receptor 2
- Lymphocyte activation gene 3 protein
- C-type lectin domain family 7 member A
- Cytotoxic T-lymphocyte protein 4
- T-cell immunoreceptor with Ig and ITIM domains
- Programmed cell death protein 1
- CD44 antigen
- Programmed cell death 1 ligand 1
- Tumor necrosis factor receptor superfamily member 9
- Lymphokine-activated killer T-cell-originated protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0002376 (immune system process), GO:0048856 (anatomical structure development), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048524 (positive regulation of viral process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0002507 (tolerance induction), GO:0051241 (negative regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0050793 (regulation of developmental process), GO:0044706 (multi-multicellular organism process), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0040017 (positive regulation of locomotion), GO:0023051 (regulation of signaling), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0002520 (immune system development), GO:0009893 (positive regulation of metabolic process), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0002695 (negative regulation of leukocyte activation), GO:2000145 (regulation of cell motility), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:1903706 (regulation of hemopoiesis), GO:0001817 (regulation of cytokine production), GO:0060135 (maternal process involved in female pregnancy), GO:0051048 (negative regulation of secretion), GO:0031348 (negative regulation of defense response), GO:0050866 (negative regulation of cell activation), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0002698 (negative regulation of immune effector process), GO:1903902 (positive regulation of viral life cycle), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:1901700 (response to oxygen-containing compound), GO:2000147 (positive regulation of cell motility), GO:0045087 (innate immune response), GO:0050867 (positive regulation of cell activation), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0033554 (cellular response to stress), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0032102 (negative regulation of response to external stimulus), GO:0050777 (negative regulation of immune response), GO:0010942 (positive regulation of cell death), GO:0032103 (positive regulation of response to external stimulus), GO:0002685 (regulation of leukocyte migration), GO:0048731 (system development), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0031341 (regulation of cell killing), GO:0007162 (negative regulation of cell adhesion), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0001819 (positive regulation of cytokine production), GO:1903708 (positive regulation of hemopoiesis), GO:0052372 (modulation by symbiont of entry into host), GO:1903531 (negative regulation of secretion by cell), GO:0008284 (positive regulation of cell population proliferation), GO:0031342 (negative regulation of cell killing), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0050920 (regulation of chemotaxis), GO:0006952 (defense response), GO:0045785 (positive regulation of cell adhesion), GO:0010033 (response to organic substance), GO:0002687 (positive regulation of leukocyte migration), GO:0002696 (positive regulation of leukocyte activation), GO:0007565 (female pregnancy), GO:1903900 (regulation of viral life cycle), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0009889 (regulation of biosynthetic process), GO:0001818 (negative regulation of cytokine production), GO:0002699 (positive regulation of immune effector process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0050921 (positive regulation of chemotaxis), GO:0046596 (regulation of viral entry into host cell), GO:0043300 (regulation of leukocyte degranulation), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022409 (positive regulation of cell-cell adhesion), GO:0002703 (regulation of leukocyte mediated immunity), GO:0051246 (regulation of protein metabolic process), GO:0033006 (regulation of mast cell activation involved in immune response), GO:0032675 (regulation of interleukin-6 production), GO:0045824 (negative regulation of innate immune response), GO:0032735 (positive regulation of interleukin-12 production), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0051251 (positive regulation of lymphocyte activation), GO:0032753 (positive regulation of interleukin-4 production), GO:0032732 (positive regulation of interleukin-1 production), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0002688 (regulation of leukocyte chemotaxis), GO:0070665 (positive regulation of leukocyte proliferation), GO:0022408 (negative regulation of cell-cell adhesion), GO:0043085 (positive regulation of catalytic activity), GO:0010629 (negative regulation of gene expression), GO:0045920 (negative regulation of exocytosis), GO:0032496 (response to lipopolysaccharide), GO:0032733 (positive regulation of interleukin-10 production), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:0033003 (regulation of mast cell activation), GO:0060284 (regulation of cell development), GO:0071636 (positive regulation of transforming growth factor beta production), GO:0017157 (regulation of exocytosis), GO:0032755 (positive regulation of interleukin-6 production), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0006954 (inflammatory response), GO:0032677 (regulation of interleukin-8 production), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0070664 (negative regulation of leukocyte proliferation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0071634 (regulation of transforming growth factor beta production), GO:0032682 (negative regulation of chemokine production), GO:0031347 (regulation of defense response), GO:0032642 (regulation of chemokine production), GO:0043067 (regulation of programmed cell death), GO:0022407 (regulation of cell-cell adhesion), GO:0002704 (negative regulation of leukocyte mediated immunity), GO:0000165 (MAPK cascade), GO:0002237 (response to molecule of bacterial origin), GO:0032655 (regulation of interleukin-12 production), GO:0032673 (regulation of interleukin-4 production), GO:0030334 (regulation of cell migration), GO:0032729 (positive regulation of type II interferon production), GO:0070663 (regulation of leukocyte proliferation), GO:0032656 (regulation of interleukin-13 production), GO:1902105 (regulation of leukocyte differentiation), GO:0051252 (regulation of RNA metabolic process), GO:0071675 (regulation of mononuclear cell migration), GO:0032757 (positive regulation of interleukin-8 production), GO:1903556 (negative regulation of tumor necrosis factor superfamily cytokine production), GO:0051091 (positive regulation of DNA-binding transcription factor activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)