Protein: 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) (P50861)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Subcellular location: Mitochondrion intermembrane space {ECO:0000269|PubMed:22984289}.
Sequence: MAVKGLGKPDQVYDGSKIRVGIIHARWNRVIIDALVKGAIERMASLGVEENNIIIETVPGSYELPWGTKRFVDRQAKLGKPLDVVIPIGVLIKGSTMHFEYISDSTTHALMNLQEKVDMPVIFGLLTCMTEEQALARAGIDEAHSMHNHGEDWGAAAVEMAVKFGKNAF
InterPro domains: - IPR036467: Lumazine/riboflavin synthase superfamily (homologous_superfamily) [2-169]
- IPR002180: Lumazine/riboflavin synthase (family) [18-162]
- IPR034964: Lumazine synthase (family) [11-167]
Interaction partners: - 3,4-dihydroxy-2-butanone 4-phosphate synthase
- Riboflavin synthase
- GTP cyclohydrolase-2
- Riboflavin kinase
- 2,5-diamino-6-ribosylamino-4
- Uncharacterized protein YMR085W
- Bifunctional protein RIB2
- Glutamine--fructose-6-phosphate aminotransferase
- Putative glutamine--fructose-6-phosphate aminotransferase
- Phosphomannomutase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0043168 (anion binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006766 (vitamin metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0009110 (vitamin biosynthetic process), GO:0042726 (flavin-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0006771 (riboflavin metabolic process), GO:0042364 (water-soluble vitamin biosynthetic process), GO:0042727 (flavin-containing compound biosynthetic process), GO:0009231 (riboflavin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)