Protein: SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein) (P97306)
Organism: Mus musculus (Mouse)
Function: Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows the rate of calcium-mediated inactivation of CACNA1C calcium channel activity.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:28112192, ECO:0000269|PubMed:29467163}. Cell membrane {ECO:0000269|PubMed:29467163}; Peripheral membrane protein {ECO:0000269|PubMed:29467163}; Cytoplasmic side {ECO:0000269|PubMed:29467163}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29363593}; Peripheral membrane protein {ECO:0000269|PubMed:29363593}; Cytoplasmic side {ECO:0000269|PubMed:29363593}.
Sequence: MIPPSGAREDSGDGLTGEATGTEQPPSPASTSSLESKLQKLKRSLSFKTKSLRSKSADNFFPRTNSDVKPQADLLAKASPGPSPIAIPGSPASMPTKAGLHPGSNSKLHAFQEHVFKKPTFCDVCNHMIVGTHAKHGLRCGACKMSIHHKCADGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYEALRFGTSLAQRTKKGGSGSGSDSPPRTSTSELVDVPEEADGPGDGSDMRTRSNSVFTYPENGMDDFRDQMKTTNHQGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGFFPANFVQRVEEHEKIYRCVRTFIGCKDQGQITLKENQICVTSEEEQDGFIRVLSGKKRGLVPLDVLVDV
InterPro domains: - IPR046349: C1-like domain superfamily (homologous_superfamily) [107-161]
- IPR039688: STAC1/2/3 (family) [23-402]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [284-345]
- IPR001452: SH3 domain (domain) [286-403]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [108-160]
- IPR035508: STAC1, SH3 domain (domain) [290-342]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:1903829 (positive regulation of protein localization), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0032409 (regulation of transporter activity), GO:0060341 (regulation of cellular localization), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:1904377 (positive regulation of protein localization to cell periphery), GO:0051928 (positive regulation of calcium ion transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0022898 (regulation of transmembrane transporter activity), GO:0032880 (regulation of protein localization), GO:0043269 (regulation of monoatomic ion transport), GO:1905477 (positive regulation of protein localization to membrane), GO:2001259 (positive regulation of cation channel activity), GO:1901021 (positive regulation of calcium ion transmembrane transporter activity), GO:1905475 (regulation of protein localization to membrane), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1904064 (positive regulation of cation transmembrane transport), GO:1904375 (regulation of protein localization to cell periphery), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:1903078 (positive regulation of protein localization to plasma membrane), GO:0010959 (regulation of metal ion transport), GO:1904427 (positive regulation of calcium ion transmembrane transport), GO:0051924 (regulation of calcium ion transport), GO:1903076 (regulation of protein localization to plasma membrane), GO:2001257 (regulation of cation channel activity), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport), GO:1901385 (regulation of voltage-gated calcium channel activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0019898 (extrinsic component of membrane), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0019897 (extrinsic component of plasma membrane), GO:0098562 (cytoplasmic side of membrane), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)