Protein: Thermosome subunit beta (Chaperonin subunit beta) (Thermophilic factor 55 beta) (TF55-beta) (Thermosome subunit 2) (Q9V2T8)
Organism: Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
Sequence: MATATVATTPEGIPVIILKEGSSRTYGKEALRANIAAVKAIEEALKSTYGPRGMDKMLVDSLGDITITNDGATILDKMDLQHPTGKLLVQIAKGQDEETADGTKTAVILAGELAKKAEDLLYKEIHPTIIVSGYKKAEEIALKTIQEIAQPVTINDTDVLRKVALTSLGSKAVAGAREYLADLVVKAVAQVAELRGDKWYVDLDNVQIVKKHGGSVNDTQLVYGIVVDKEVVHPGMPKRIENAKIALLDASLEVEKPELDAEIRINDPTQMHKFLEEEENILKEKVDKIAATGANVVICQKGIDEVAQHYLAKKGILAVRRAKKSDLEKLARATGGRVISNIDELTSQDLGYAALVEERKVGEDKMVFVEGAKNPKSVSILIRGGLERVVDETERALRDALGTVADVIRDGRAVAGGGAVEIEIAKRLRKYAPQVGGKEQLAIEAYANAIEGLIMILAENAGLDPIDKLMQLRSLHENETNKWYGLNLFTGNPEDMWKLGVIEPALVKMNAVKAATEAVTLVLRIDDIVAAGKKSGSEPSGKKEKDKEEKSSED
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [152-410]
- IPR053374: TCP-1 chaperonin-containing T-complex (family) [13-531]
- IPR012714: Thermosome, archaeal (family) [14-532]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [218-384]
- IPR054827: Thermosome subunit alpha (family) [14-531]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [41-532]
- IPR002194: Chaperonin TCP-1, conserved site (conserved_site) [46-103]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [23-530]
- IPR017998: Chaperone tailless complex polypeptide 1 (TCP-1) (family) [27-532]
Interaction partners: - Thermosome subunit alpha
- TATA-box-binding protein
- Translation initiation factor 5A
- Prefoldin subunit alpha
- Proteasome subunit beta 1
- Large ribosomal subunit protein uL4
- Probable translation initiation factor IF-2
- Prefoldin subunit beta
- Proteasome subunit alpha
- GTPase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0035821 (modulation of process of another organism), GO:0048584 (positive regulation of response to stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0005832 (chaperonin-containing T-complex), GO:0101031 (chaperone complex)