Protein: Dystrophin, isoforms A/C/F/G/H (DmDYS) (Protein detached) (Q9VDW6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for the maintenance of appropriate synaptic retrograde communication and the stabilization of muscle cell architecture or physiology. Both det and Dg are required for maintenance of early dpp signaling in the presumptive crossvein. Isoform A is not required to maintain muscle integrity, but plays a role in neuromuscular homeostasis by regulating neurotransmitter release. May play a role in anchoring the cytoskeleton to the plasma membrane.
Subcellular location: Cell membrane, sarcolemma {ECO:0000269|PubMed:16399704}; Peripheral membrane protein {ECO:0000269|PubMed:16399704}; Cytoplasmic side {ECO:0000269|PubMed:16399704}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16399704}. Note=Isoform A is localized to both the postsynaptic region of the NMJ and to the extrasynaptic regions, where it colocalizes with actin.
Sequence: MEPGILIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVEKSLLAWARQYTEPHGLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKRLHLAFDLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVISARNFSEILIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLDKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSSAHTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRISFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLTKAKIEQCHESEAEDLRLLIAPDAATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDLQVIVSAIGKNAQMPKVTPLMMNEIEKTKNNLIAHADSIELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPSGTGALAGSFDKSVLQISDWLTWEQNMIKIQSVLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKVTRLREHWDETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKWLARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAESDIERNPLMFKDLQSEIETHRVVYDRLDGTGRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVALAEQTKTSWLPPSSVGEANEQMQQLQRLRDKMTTASALLDDCNEQQSFFTANQVLVPTPCLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPNLGQSVKPPWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPVQSVLEGDALESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEPNGGGSSATSSGLPSAPGSALNSKPNTLQTRSVTASQLNTDSPAKMNQQNGHYEHNSKGIMLPGMNSEIQQQHAQLASLAAKHHQHQLSGALNALHQQQQQQLQQQPPQQQRSMMTGNGGMDISGGMQTSGGYLGDDGRPPPPPHSSLMQQQHQQHLNENSSGLVTVITEQELESINDDLEDSSSSNTTNTTTTTTTTATTEKTCVELQK
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [6-234]
- IPR001202: WW domain (domain) [2849-2882]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [14-111]
- IPR050774: KCMF1 and Dystrophin (family) [2546-3540]
- IPR000433: Zinc finger, ZZ-type (domain) [3106-3163]
- IPR018159: Spectrin/alpha-actinin (repeat) [310-2818]
- IPR002017: Spectrin repeat (repeat) [1197-2575]
- IPR011992: EF-hand domain pair (homologous_superfamily) [2879-3104]
- IPR043145: Zinc finger, ZZ-type superfamily (homologous_superfamily) [3100-3161]
- IPR015153: EF-hand domain, type 1 (domain) [2884-2997]
- IPR015154: EF-hand domain, type 2 (domain) [3001-3101]
- IPR036020: WW domain superfamily (homologous_superfamily) [2846-2878]
- IPR035436: Dystrophin/utrophin (family) [5-3515]
- IPR001715: Calponin homology domain (domain) [12-230]
Interaction partners: - Dystroglycan 1
- Dystrobrevin, isoform F
- IP02644p
- FI16515p1
- Sarcoglycan alpha, isoform C
- EG:4F1.1 protein
- Alpha-actinin, sarcomeric
- Beta-sarcoglycan
- GH23568p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0016203 (muscle attachment), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0030029 (actin filament-based process), GO:0001763 (morphogenesis of a branching structure), GO:0007017 (microtubule-based process), GO:0051094 (positive regulation of developmental process), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0008038 (neuron recognition), GO:0051129 (negative regulation of cellular component organization), GO:0035148 (tube formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0032886 (regulation of microtubule-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0035239 (tube morphogenesis), GO:0048639 (positive regulation of developmental growth), GO:0045597 (positive regulation of cell differentiation), GO:0001558 (regulation of cell growth), GO:0061138 (morphogenesis of a branching epithelium), GO:0051130 (positive regulation of cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0016319 (mushroom body development), GO:0030307 (positive regulation of cell growth), GO:0030036 (actin cytoskeleton organization), GO:0045165 (cell fate commitment), GO:0061061 (muscle structure development), GO:0001709 (cell fate determination), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0060322 (head development), GO:0035152 (regulation of tube architecture, open tracheal system), GO:0016358 (dendrite development), GO:0032535 (regulation of cellular component size), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0045773 (positive regulation of axon extension), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0043244 (regulation of protein-containing complex disassembly), GO:0002009 (morphogenesis of an epithelium), GO:0050769 (positive regulation of neurogenesis), GO:0001578 (microtubule bundle formation), GO:0060491 (regulation of cell projection assembly), GO:0048666 (neuron development), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0061387 (regulation of extent of cell growth), GO:0007420 (brain development), GO:1902903 (regulation of supramolecular fiber organization), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0035146 (tube fusion), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0007417 (central nervous system development), GO:0048813 (dendrite morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0035149 (lumen formation, open tracheal system), GO:0031344 (regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0030716 (oocyte fate determination), GO:0010720 (positive regulation of cell development), GO:0016198 (axon choice point recognition), GO:0051960 (regulation of nervous system development), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0022008 (neurogenesis), GO:0010639 (negative regulation of organelle organization), GO:0050770 (regulation of axonogenesis), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0031346 (positive regulation of cell projection organization), GO:0060541 (respiratory system development), GO:0030516 (regulation of axon extension), GO:0033043 (regulation of organelle organization), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0051491 (positive regulation of filopodium assembly), GO:0051494 (negative regulation of cytoskeleton organization), GO:0031114 (regulation of microtubule depolymerization), GO:0050772 (positive regulation of axonogenesis), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0031111 (negative regulation of microtubule polymerization or depolymerization), GO:0007424 (open tracheal system development), GO:0007010 (cytoskeleton organization), GO:0007026 (negative regulation of microtubule depolymerization), GO:0035147 (branch fusion, open tracheal system), GO:0007411 (axon guidance), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1901879 (regulation of protein depolymerization), GO:0060538 (skeletal muscle organ development), GO:0120036 (plasma membrane bounded cell projection organization), GO:1901880 (negative regulation of protein depolymerization), GO:0008361 (regulation of cell size), GO:0031175 (neuron projection development), GO:0016199 (axon midline choice point recognition), GO:0060446 (branching involved in open tracheal system development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0051489 (regulation of filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:1990752 (microtubule end), GO:0042995 (cell projection), GO:0030427 (site of polarized growth), GO:0030054 (cell junction), GO:0099080 (supramolecular complex), GO:0045169 (fusome), GO:0005737 (cytoplasm), GO:0035371 (microtubule plus-end), GO:0005881 (cytoplasmic microtubule), GO:0120025 (plasma membrane bounded cell projection), GO:0005818 (aster), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070161 (anchoring junction), GO:0030426 (growth cone), GO:0099081 (supramolecular polymer), GO:0030055 (cell-substrate junction), GO:0098858 (actin-based cell projection), GO:0000235 (astral microtubule), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0044295 (axonal growth cone), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0005911 (cell-cell junction), GO:0099513 (polymeric cytoskeletal fiber), GO:0030175 (filopodium), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0005927 (muscle tendon junction), GO:0005912 (adherens junction), GO:0030424 (axon), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0005876 (spindle microtubule)