Protein: Collagen alpha-1(XIV) chain (Q80X19)
Organism: Mus musculus (Mouse)
Function: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P32018}.
Sequence: MMIWQCKMRDWLILAFLAAACFCTIVRGQVAPPTRLRYNVISHDSIQISWKAPRGKFGGYKLLVAPASGGKTNQMNLQNTATKAIIQGLLPEQNYTVQLIAYYKDKESKPAQGQFRIKDLEKRKDPTKPKVKVVDKGNGSKPTSPEEVKFFCETPAIADIVILVDGSWSIGRFNFRLVRNFLENLVTAFNVGSEKTRIGLAQYSGDPRIEWHLNAFNTKDEVIDAVRSLPYKGGNTLTGLALNFIFENSFKPEAGSRSGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADLSELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTVCSRVEEQDKEIKASALATIGPPTELITSEVTARSFMVNWTQSPGKVEKYRVVYYPTRGGKPEEVVVDGSVSSTVLKNLMSSTEYQIAVFAVSAHTASEGLRGAETTLALPMASDLELYDVTENSMRVRWDAVPGATGYLILYAPLTEGLAGDEKEMKIGETHTDIELSGLFPNTEYTVTVYAMFGEEASDPATGQETTLPLTPPRNLRISNVGSNSARLTWDPASGKISGYRIVYTSADGTEINEVEVDPITTFPLKGLTPLTEYSIAIFSIYEEGQSLPLVGEFTTEEVPAQQYLEIDEVKTDSFRVTWHPLSAEEGQHKLMWIPVYGGKTQEVDLKEEQDSYVIEGLDPGTEYEVSLLAVLDDGSESEVVTAVGTTLDDFWTEAPTAIEPTSPVTSVLQTGIRNLVVDDETATSLRVSWDISDSNVEQFRVTYLKAQGDPMEEVVGTVMVPGVQNSLLLKALLPDTEYKVTVTPVYTVGEGVSVSAPGKTLPSSGPQNLRVSEEWYNRVRITWDPPSGPVKGYRIVYKPVSVPGQTLETFVGADINTIVMTNLLSGMDYNVKIFASQASGFSDALTGLVQTLFLGVTDLQANQVEMTSLCARWQIHRHATAYRIVLESLQDTQAQESTVGGGVNRHCFYGLQPDSEYKISVYTKLQELEGPSVSIMQKTQSLPTEPPTFPPTIPPAKEVCKAAKADLVFMVDGSWSIGDDNFNKIINFLYSTVGALDKIGADGTQVAMVQFTDDPRTEFKLDSYKTKETLLDAIRHISYKGGNTKTGKAIKHVRDTLFTSDSGTRRGIPKVIVVITDGRSQDDVNKISREMQADGFNIFAIGVADADYSELVQIGSKPSSRHVFFVDDFDAFKKIEDELITFVCETASATCPMVHKDGVDLAGFKMMEMFGLVEKDFSAVEGVSMEPGTFNLFPCYQIHKDALVSQPTKYLHPEGLPSDYTMSFLFRILPDTPQEPFALWEILNKNSEPLVGIILDNGGKTLTYFNYDYTGDFQTVTFEGPDIRKMFYGSFHKLHVVVSKTLAKVVVDCKEVGQKAINASANITSDGVEVLGRMVRSRGPNGNSAPFQLQMFDIVCSTSWASKDRCCELPGLRDEESCPDLPRSCSCSETNEVALGPAGPPGGPGLRGPKGQQGEQGPKGPEGPRGETGPAGPQGPPGPQGPSGLSIQGMPGMPGDKGDKGDAGLPGPQGVPGGVGSPGRDGSPGQRGFPGKDGSSGPPGPPGPIGIPGAPGVPGITGSMGPQGALGPPGVPGAKGERGERGDLQSQAMVRAVARQVCEQLIQSHMARYTAILNQIPSQSSSIRTIQGPPGEPGRPGSPGTPGEQGPPGTPGFPGNAGVPGTPGERGLTGVKGEKGNPGIGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGVGVSHPDQPEFTPVQDEQEAMDLWSAGI
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [32-1006]
- IPR003961: Fibronectin type III (domain) [30-999]
- IPR002035: von Willebrand factor, type A (domain) [157-1211]
- IPR008160: Collagen triple helix repeat (repeat) [1463-1706]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [1230-1434]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [26-1015]
- IPR050525: Extracellular Matrix Assembly and Organization (family) [60-1433]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [147-1220]
- IPR048287: Thrombospondin-like, N-terminal domain (domain) [1230-1425]
Interaction partners: - Collagen alpha-2
- Decorin
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Lumican
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0008201 (heparin binding), GO:0005518 (collagen binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0045229 (external encapsulating structure organization), GO:0043062 (extracellular structure organization), GO:0022607 (cellular component assembly), GO:0030198 (extracellular matrix organization), GO:0085029 (extracellular matrix assembly), GO:0071711 (basement membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0005615 (extracellular space), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)