Protein: Arginine permease CAN1 (Canavanine resistance protein 1) (P04817)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity permease for arginine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12100990, ECO:0000269|PubMed:14551254, ECO:0000269|PubMed:21223946, ECO:0000269|PubMed:21880895, ECO:0000269|PubMed:37005249}; Multi-pass membrane protein {ECO:0000269|PubMed:21880895}. Endosome membrane {ECO:0000269|PubMed:21880895}; Multi-pass membrane protein {ECO:0000269|PubMed:21880895}. Note=Recycled via the retromer-mediated pathway (PubMed:21880895). Requires phosphatidyl ethanolamine (PE) for localization and exclusively associated with lipid rafts called MCCs (membrane compartment occupied by CAN1) (PubMed:12100990, PubMed:14551254, PubMed:21223946). {ECO:0000269|PubMed:12100990, ECO:0000269|PubMed:14551254, ECO:0000269|PubMed:21223946, ECO:0000269|PubMed:21880895}.
Sequence: MTNSKEDADIEEKHMYNEPVTTLFHDVEASQTHHRRGSIPLKDEKSKELYPLRSFPTRVNGEDTFSMEDGIGDEDEGEVQNAEVKRELKQRHIGMIALGGTIGTGLFIGLSTPLTNAGPVGALISYLFMGSLAYSVTQSLGEMATFIPVTSSFTVFSQRFLSPAFGAANGYMYWFSWAITFALELSVVGQVIQFWTYKVPLAAWISIFWVIITIMNLFPVKYYGEFEFWVASIKVLAIIGFLIYCFCMVCGAGVTGPVGFRYWRNPGAWGPGIISKDKNEGRFLGWVSSLINAAFTFQGTELVGITAGEAANPRKSVPRAIKKVVFRILTFYIGSLLFIGLLVPYNDPKLTQSTSYVSTSPFIIAIENSGTKVLPHIFNAVILTTIISAANSNIYVGSRILFGLSKNKLAPKFLSRTTKGGVPYIAVFVTAAFGALAYMETSTGGDKVFEWLLNITGVAGFFAWLFISISHIRFMQALKYRGISRDELPFKAKLMPGLAYYAATFMTIIIIIQGFTAFAPKFNGVSFAAAYISIFLFLAVWILFQCIFRCRFIWKIGDVDIDSDRRDIEAIVWEDHEPKTFWDKFWNVVA
InterPro domains: - IPR050524: Amino Acid-Polyamine-Organocation Superfamily YAT (family) [64-588]
- IPR004762: Amino acid permease, fungi (family) [85-562]
- IPR004841: Amino acid permease/ SLC12A domain (domain) [92-554]
- IPR004840: Amino acid permease, conserved site (conserved_site) [117-148]
Interaction partners: - Imidazoleglycerol-phosphate dehydratase
- N-
- Phosphoribosylaminoimidazole carboxylase
- Orotidine 5'-phosphate decarboxylase
- 3-isopropylmalate dehydrogenase
- Protein SUR7
- L-2-aminoadipate reductase
- DNA repair protein RAD5
- Saccharopepsin
- Uracil permease
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015174 (basic amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015849 (organic acid transport), GO:0006865 (amino acid transport), GO:0015711 (organic anion transport), GO:0015802 (basic amino acid transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0032126 (eisosome), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)