Protein: Tetraketide alpha-pyrone reductase 2 (EC 1.1.1.-) (Protein CINNAMOYL-COA REDUCTASE-LIKE 6) (Q9CA28)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in the biosynthesis of hydroxylated tetraketide compounds that serve as sporopollenin precursors (the main constituents of exine). Acts on tetraketide alpha-pyrones and reduces the carbonyl function on the tetraketide alkyl chain to a secondary alcohol function.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21193572}.
Sequence: MSEYLVTGGTGFIASYIIKSLLELGHTVRTTVRNPRDEEKVGFLWEFQGAKQRLKILQADLTVEGSFDEAVNGVDGVFHTASPVLVPQDHNIQETLVDPIIKGTTNVMSSCAKSKATLKRIVLTSSCSSIRYRFDATEASPLNESHWSDPEYCKRFNLWYGYAKTLGEREAWRIAEEKGLDLVVVNPSFVVGPLLGPKPTSTLLMILAIAKGLAGEYPNFTVGFVHIDDVVAAHVLAMEEPKASGRIICSSSVAHWSEIIELMRNKYPNYPFENKCSNKEGDNSPHSMDTRKIHELGFGSFKSLPEMFDDCIISFQKKGLL
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [4-312]
- IPR050425: NAD(P)-dependent dehydratase-like (family) [5-289]
- IPR001509: NAD-dependent epimerase/dehydratase (domain) [5-244]
Interaction partners: - Type III polyketide synthase A
- Type III polyketide synthase B
- Cytochrome P450 703A2
- Cytochrome P450 704B1
- 4-coumarate--CoA ligase-like 1
- Putative acyl-activating enzyme 19
- Small ribosomal subunit protein uS14z/uS14y/uS14x
- Pentatricopeptide repeat-containing protein At4g08210
- ABC transporter G family member 26
- No exine formation 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0032989 (cellular component morphogenesis), GO:0048316 (seed development), GO:0044085 (cellular component biogenesis), GO:0048731 (system development), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0048608 (reproductive structure development), GO:0006725 (cellular aromatic compound metabolic process), GO:0048229 (gametophyte development), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0061458 (reproductive system development), GO:0009555 (pollen development), GO:0010208 (pollen wall assembly), GO:0019438 (aromatic compound biosynthetic process), GO:0045229 (external encapsulating structure organization), GO:0010154 (fruit development), GO:0022607 (cellular component assembly), GO:0010584 (pollen exine formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)