Protein: Hypoxia-inducible factor 1-alpha (Q6EHI4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MDTGVVTEKKRVSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLNSDEKEEKEENELESQLNGFYLKALEGFLMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSIFEFSHPCDHEELREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRVHEGSEASEDSGFKEPPVTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQATTGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAVEKESEETEEKTSELDILKLFKPESLNCSLESSTLYNKLKEEPEALTVLAPAAGDAIISLDFNNSDSDIQLLKEVPLYNDVMLPSSSEKLPLSLSPLTPSDSIPALTKLETGGEDFPFSSASDRVPDPTNTPSTSGLGSSGPNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFSTQPMEDLDLEMLAPYIPMDDDFQLRIPSPLDPLPSATHSVSAMSSLFQPLPSSPASPASSTSSTVKQEASSRAPSPLHLLQEVCSAPVSPFSGSRDASPVRSSTPQSSSQLNNREMSPKMLAFQNIQRKRKLNEVTSLSEAVGLGALLHSVDSAIDPGKRAKVLEVKGSSVLGGNKTILILPSDVASRLLSSSLEGSGGLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQVN
InterPro domains: - IPR014887: HIF-1 alpha, C-terminal transactivation domain (domain) [741-776]
- IPR000014: PAS domain (domain) [81-338]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [7-87]
- IPR001321: Hypoxia-inducible factor-1 alpha (family) [201-445]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [3-77]
- IPR035965: PAS domain superfamily (homologous_superfamily) [97-343]
- IPR001610: PAC motif (repeat) [302-345]
- IPR021537: Hypoxia-inducible factor, alpha subunit-like (domain) [543-573]
Interaction partners: - Egl-9 family hypoxia-inducible factor 3.
- Hypoxia-inducible factor 1-alpha inhibitor
- Hypoxia-inducible factor 1 subunit alpha,-like
- Hypoxia-inducible factor 1-alpha
- hypoxia-inducible factor-proline dioxygenase
- Catenin beta-1
- Cellular tumor antigen p53
- Aryl hydrocarbon receptor nuclear translocator.
- Von Hippel-Lindau tumor suppressor.
- Cullin 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0048863 (stem cell differentiation), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0007219 (Notch signaling pathway), GO:0060218 (hematopoietic stem cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005667 (transcription regulator complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)