Protein: HERV-H LTR-associating protein 2 (Human endogenous retrovirus-H long terminal repeat-associating protein 2) (Q9UM44)
Organism: Homo sapiens (Human)
Function: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Sequence: MKAQTALSFFLILITSLSGSQGIFPLAFFIYVPMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDSYKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKVGVFLTPVMKYEKRNTNSFLICSVLSVYPRPIITWKMDNTPISENNMEETGSLDSFSINSPLNITGSNSSYECTIENSLLKQTWTGRWTMKDGLHKMQSEHVSLSCQPVNDYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIINESRFSWNKELINQSDFSMNLMDLNLSDSGEYLCNISSDEYTLLTIHTVHVEPSQETASHNKGLWILVPSAILAAFLLIWSVKCCRAQLEARRSRHPADGAQQERCCVPPGERCPSAPDNGEENVPLSGKV
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [46-333]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [37-334]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [30-347]
- IPR007110: Immunoglobulin-like domain (domain) [157-328]
- IPR003599: Immunoglobulin domain subtype (domain) [36-335]
- IPR050504: Immunoglobulin superfamily BTN/MOG domain-containing protein (family) [10-219]
- IPR003597: Immunoglobulin C1-set (domain) [144-215]
Interaction partners: - Putative uncharacterized protein ANKRD13C-DT
- Transmembrane and immunoglobulin domain-containing protein 2
- Killer cell immunoglobulin-like receptor 3DL3
- Cytotoxic T-lymphocyte protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0010942 (positive regulation of cell death), GO:0002695 (negative regulation of leukocyte activation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:0001817 (regulation of cytokine production), GO:0046649 (lymphocyte activation), GO:0050867 (positive regulation of cell activation), GO:0002643 (regulation of tolerance induction), GO:0002696 (positive regulation of leukocyte activation), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0050866 (negative regulation of cell activation), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0007162 (negative regulation of cell adhesion), GO:0002833 (positive regulation of response to biotic stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0001818 (negative regulation of cytokine production), GO:0001819 (positive regulation of cytokine production), GO:0050865 (regulation of cell activation), GO:0031295 (T cell costimulation), GO:0008284 (positive regulation of cell population proliferation), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0032649 (regulation of type II interferon production), GO:0002836 (positive regulation of response to tumor cell), GO:0010628 (positive regulation of gene expression), GO:0032689 (negative regulation of type II interferon production), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0010468 (regulation of gene expression), GO:0032693 (negative regulation of interleukin-10 production), GO:0032693 (negative regulation of interleukin-10 production), GO:0051251 (positive regulation of lymphocyte activation), GO:0070664 (negative regulation of leukocyte proliferation), GO:0032653 (regulation of interleukin-10 production), GO:0002821 (positive regulation of adaptive immune response), GO:0070665 (positive regulation of leukocyte proliferation), GO:0022408 (negative regulation of cell-cell adhesion), GO:1903556 (negative regulation of tumor necrosis factor superfamily cytokine production), GO:0010629 (negative regulation of gene expression), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0050670 (regulation of lymphocyte proliferation), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0050863 (regulation of T cell activation), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0032944 (regulation of mononuclear cell proliferation), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0050868 (negative regulation of T cell activation), GO:0050864 (regulation of B cell activation), GO:0050871 (positive regulation of B cell activation), GO:0042102 (positive regulation of T cell proliferation), GO:0046636 (negative regulation of alpha-beta T cell activation), GO:2000106 (regulation of leukocyte apoptotic process), GO:0046634 (regulation of alpha-beta T cell activation), GO:2000108 (positive regulation of leukocyte apoptotic process), GO:0042129 (regulation of T cell proliferation), GO:0046640 (regulation of alpha-beta T cell proliferation), GO:0046006 (regulation of activated T cell proliferation), GO:0070228 (regulation of lymphocyte apoptotic process), GO:2000515 (negative regulation of CD4-positive, alpha-beta T cell activation), GO:2001185 (regulation of CD8-positive, alpha-beta T cell activation), GO:2000514 (regulation of CD4-positive, alpha-beta T cell activation), GO:0070230 (positive regulation of lymphocyte apoptotic process), GO:2000561 (regulation of CD4-positive, alpha-beta T cell proliferation), GO:0070232 (regulation of T cell apoptotic process), GO:0070234 (positive regulation of T cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)