Protein: Phosphatidylinositol transfer protein beta isoform (PI-TP-beta) (PtdIns transfer protein beta) (PtdInsTP beta) (P48739)
Organism: Homo sapiens (Human)
Function: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function.
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:P53811}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53812}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53812}.
Sequence: MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV
InterPro domains: - IPR023393: START-like domain superfamily (homologous_superfamily) [2-271]
- IPR001666: Phosphatidylinositol transfer protein (family) [3-260]
- IPR055261: Phosphatidylinositol transfer protein, N-terminal (domain) [2-252]
Interaction partners: - Membrane-associated phosphatidylinositol transfer protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0008289 (lipid binding), GO:0005319 (lipid transporter activity), GO:0050997 (quaternary ammonium group binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0031210 (phosphatidylcholine binding), GO:0043168 (anion binding), GO:0005548 (phospholipid transporter activity), GO:0043169 (cation binding), GO:0120013 (lipid transfer activity), GO:0120014 (phospholipid transfer activity), GO:0008525 (phosphatidylcholine transporter activity), GO:0035091 (phosphatidylinositol binding), GO:1901611 (phosphatidylglycerol binding), GO:0008526 (phosphatidylinositol transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0050877 (nervous system process), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:0007600 (sensory perception), GO:0015914 (phospholipid transport), GO:0015748 (organophosphate ester transport), GO:0050953 (sensory perception of light stimulus), GO:0007601 (visual perception)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)