wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Importin 1 (Q38D75)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MRRSVVAQGFSSFFTSHLSNNYYFGDYPIAVMGSVGQAILIALASASDPDPGVRHRGEAQLLELKANPHAFFTSCAELLVDANVPVRGRQLVGFMLKNSLSHPCCVQNPGLQNSVMTQAVVDADFSIRSVACTIISCAVRDGHWPVDPVVKVLTEIITTRRGDISALHGAMRALSQIVDDCVQLLDMRRLTGAVVEAILPFLQAPVAPGREGEEVQLGALEAMAILLEQAGMEVNNVSYASLQPHALTVLESCLHNLQNPPSDRLATRCVKCLVLVLCFHEAIPDHLFHNLANLMSLMMTSVEGRGEEIRIEATEFWRGCLCFPRFATLIEPMLDSLIPVLIHSMVYSEMEIGMLQANAEDWNVPDKIDEIRPRHYQARVNDTAADEDEDGGDGDGDEVEEWNLRRVSALTLDTIAEYYGERIVFTVLTSIDDMMQPSKPWQLLEAAILALGAIMDGCFSFMTPYLKDISDRLLQLLRDPSAHFLVVSISLWTGTQIGQYFVSDAEILKNFLTCVLQRMQSPSKLVQESATAALQKIINLCDDGQLSNEVPVIVGSITQCLRGYQLKNRVLLLETLETVCDVLEEPLRSSPDSVEALMGPLGAIWSETSNDSPLIFSFFSCMSGVCRAIGPSIQPALAREVFERSYQMLLLHVQKRAEAKQLGEDPPEYEFLVTSGDLLSGLFDALGGTLEPLVEQCNPALISTVIQMTLDEDIEVRRSGFSLLGDVAKNVPVLVQQRLGDVVKSAMDNLADFSDNTSSVASNVAWCLCNLLENQMDVNGVQMLDVTNGLPQLFAAIAHILGGRSLTADMRNMVENMCVCLGYMLYTNPEVESISGCPLELFAERFCMYMRNVKDGPHTEAALKGFIGATRQKVPFVVGLLHLFFDLAISVASSSAELKGSILELLNAAKAHNPSLWQEKMLQYSEQLRVRLYHVYGIQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [38-915]
- IPR040122: Importin beta family (family) [46-856]
- IPR011989: Armadillo-like helical (homologous_superfamily) [35-938]
Interaction partners: - GTP-binding nuclear protein
- RNA binding protein, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cyclin-dependent kinase inhibitor 3 (EC 3.1.3.16) (EC 3.1.3.48) (CDK2-associated dual-specificity phosphatase) (Cyclin-dependent kinase interactor 1) (Cyclin-dependent kinase-interacting protein 2) (Kinase-associated phosphatase) (Q16667)
Organism: Homo sapiens (Human)
Function: May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:10669749}.
Sequence: MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSDTISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [23-212]
- IPR050561: Protein Tyrosine Phosphatase (family) [20-199]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [135-187]
- IPR022778: CDKN3 domain (domain) [1-168]
- IPR020422: Dual specificity protein phosphatase domain (domain) [33-201]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [101-195]
- IPR008425: Cyclin-dependent kinase inhibitor 3 (family) [1-212]
Interaction partners: - Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- Disks large-associated protein 5
- Cyclin-A2
- Cyclin-dependent kinase inhibitor 1
- G2/mitotic-specific cyclin-B1
- Cyclin-dependent kinase 6
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- G2/mitotic-specific cyclin-B2
- Baculoviral IAP repeat-containing protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation), GO:0035335 (peptidyl-tyrosine dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Transmembrane protein 176A (Gene signature 188) (Kidney-expressed gene 2 protein) (Q9DCS1)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MSTDMETAVVGKVDPEAPQPTHIDVHIHQESALAKLLLAGCSLLRIPASASTQSQGSSRVLVASWVVQTVLGALSVVLGGTLYIGHYLAMYSEGAPFWTGIVAMLAGAVAFLHKKRGGTCWALMRTLLVLASFCTAVAAIVIGSRELNFYWYFLGDDVCQRDSSYGWSTMPRTTPVPEEADRIALCIYYTSMLKTLLMSLQAMLLGIWVLLLLASLTPVCVYIWKRFFTKAETEEKKLLGAAVI
InterPro domains: - IPR007237: CD20-like family (family) [64-222]
- IPR009281: Transmembrane protein 176A/B (family) [1-242]
Interaction partners: - Transmembrane protein 176B
- Membrane-spanning 4-domains, subfamily A, member 18
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009653 (anatomical structure morphogenesis), GO:0048856 (anatomical structure development), GO:0009887 (animal organ morphogenesis), GO:0048513 (animal organ development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: RE42475p (Uncharacterized protein, isoform A) (Uncharacterized protein, isoform B) (Q8SYQ4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MSFHFAVLTLILTAFTVSLCAEQKITKSDAGEIRIFKRLIPADVLRDFPGMCFASTRCATVEPGKSWDLTPFCGRSTCVQNEENDAKLFELVEDCGPLPLANDKCKLDTEKTNKTASFPYCCPIFTCDPGVKLEYPEIGKDNDKKNSE
InterPro domains: - IPR029277: Single domain Von Willebrand factor type C domain (domain) [52-127]
Interaction partners: - GEO11412p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008061 (chitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0019953 (sexual reproduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4) (Q9QY61)
Organism: Mus musculus (Mouse)
Function: Likely to be an important mediator of ventricular differentiation during cardiac development.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MSYPQFGYPYSSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGSPYGSSQGYGNYVTYGSEASAFYSLNSFESKDGTGSSHAGLPPTAAAAYYPYEPALSQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYGEGEEEEAGEEESREEPLKSAKSEGHAGKDDKELELSDLEDFDPLDAETSECELKTPFQSLDSGPERIPASSDGPGTGKEASTTLRMPLGTAGGAVMDGDLERARNCLRSTVVVPDSGAEGGPPACEAKLTFAQAGAPPNLETKPRIWSLAHTATAAAATALSQTEFPSCMLKRQGPTGVSATTPASSPAVTAPSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRNLGAGTNVLTTPLACSFPPTVPQDVPPAGASRELLATPKAGGKPFCT
InterPro domains: - IPR001356: Homeodomain (domain) [141-208]
- IPR003893: Iroquois-class homeodomain protein (domain) [362-379]
- IPR008422: KN homeodomain (domain) [161-200]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [145-211]
- IPR017970: Homeobox, conserved site (conserved_site) [179-202]
Interaction partners: - Homeobox protein Nkx-2.5
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
- Natriuretic peptides A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001217 (DNA-binding transcription repressor activity), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0003002 (regionalization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Extracellular leucine-rich repeat and fibronectin type III domain-containing 1b (Protein ELFN1) (F1Q7Y5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MTEAQMSISSGSSGHGGGMVTSALLCWAVALVFLSLTRVPVVQGDCWLIEGEKGFVWLAICSQNQPPYENIPMHINSTIVDLRLNENKIRSIHFSSLSRFGNLTYLNLTKNDISYIEDGAFSAQFNLQVLQIGFNKMRNLTEGMLRGLGRLQYLYLQANLIETVTANAFWECPAIENIDLSMNRIQQLDGATFRGLSKLTTCELYANPFSCSCELLGFLRWLVAFPNRTSERMACDTPAGFSGYSLLSQNPRMPRYRNAFHALSSVCTDDNVTPYLHGSPDGGIPTRLPDLSPCGLDDCSSGTFPEETISISPTFLDSDARPIMKLKEVTHTSAVITIQIPNPFRKMYILVLYNNSFFTDIQNLKSQREEIELQNLKSHTNYTYCVASIRNSLRFNHTCLTISTGPRTLQERVVNDSTATHYIMTILGCLFGMLIVLGVVVHCLRKRKKQDEPKSKKLEKMKRNLIEMKYGTELEQGTISQLSQKQILSAGETVQRMPYLPAASDTDQYKMQEISGTPKTTKGNYMEVRSEQPERSIRECSVPPSETSQGSVAEISTIAKEVDKVNQIINNCIDALKSDSTSFQTAKSGAVSTAEPQLVLISEHPPGKSGFLSPVYKGGYHHPLQRHHSMDAPQKRASTSSSGSLRSPRSFRSEGAYRSESKYIEKASPQDESGIITVTPAAAILRAEAERIRQYSEHRHSYPGPHHIEESIEVSGSRKSSILEPLTRSRPRELSYSQLSPQYHNLSGYSSPEYSCRPSLSLWERFKLHRKRHRDEEEYIAAGHALRRKVQFAKDEDLHDILDYWKGVSAQQKS
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [55-259]
- IPR050541: Leucine-rich repeat and transmembrane domain-containing protein (family) [74-805]
- IPR055106: ELFN1/ELFN2, fibronectin type-III domain (domain) [322-404]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [100-195]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [207-252]
- IPR001611: Leucine-rich repeat (repeat) [102-185]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048013 (ephrin receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Uncharacterized transporter C757.13 (O74923)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Endoplasmic reticulum {ECO:0000269|PubMed:16823372}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSSITSRVSSRSSHELTEKKSGVTNDFKNSFEVGEVKRLPDAEGTADAVAQELLADDDFTYTAKEARRVLWKIDLVMMPVMCITYMIQYLDKTALSYAALYGMKTDTHIDGHTYSSMTTLFYAGYLVAQYPAAILMQKCRLSYFIFCNVFLWSAMVCLMAACRNGPSLLGLRFLAGIFEASITPAFINITAMWYRREEQPMRTLCWYAFNGIAQIIGSILSYGLGHIHGKVASWRYVFIVIGLMSLGWGVVFVFIPSNPSKARFLSSREKRIALERVRDNRTGLENKQFKWKHAYEAFLDPQVIMITLFTGVCMITNGIGVFSTLIIKGLGYNELHSAVLNMPLGAIEVAAMFISGVLCKVFKNGRLLIGVFMNCLTLAGCLMIWKIPDSNPYGRLVGVWFTMWVPASSALLLSLISSNVAGYTKKTVTSATVFVFYSVGNIVSPQLFKSGQTPEYIEGIQAMIVSLCIIIAIAFVLTGYYIYENKRRDRLLAEDPSLGESIKNEEFMDLTDRQQPKFRYRW
InterPro domains: - IPR011701: Major facilitator superfamily (family) [81-445]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [63-489]
- IPR020846: Major facilitator superfamily domain (domain) [77-486]
Interaction partners: - U4/U6.U5 small nuclear ribonucleoprotein component snu23
- UPF0494 membrane protein C212.04c
- WW domain-containing protein C11B10.08
- Uncharacterized transcriptional regulatory protein C11D3.11c
- Uncharacterized cox1 intron-2 37.2 kDa protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:1904680 (peptide transmembrane transporter activity), GO:0035673 (oligopeptide transmembrane transporter activity), GO:0071916 (dipeptide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0098739 (import across plasma membrane), GO:0006810 (transport), GO:0089718 (amino acid import across plasma membrane), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006835 (dicarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2) (O14796)
Organism: Homo sapiens (Human)
Function: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse. Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
Sequence: MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETFVNSNSDYVDVLP
InterPro domains: - IPR036860: SH2 domain superfamily (homologous_superfamily) [1-104]
- IPR035049: EAT-2, SH2 domain (domain) [1-103]
- IPR000980: SH2 domain (domain) [3-101]
Interaction partners: - Natural killer cell receptor 2B4
- SLAM family member 5
- SLAM family member 6
- T-lymphocyte surface antigen Ly-9
- Signaling lymphocytic activation molecule
- SLAM family member 7
- Eukaryotic initiation factor 4A-I
- Tyrosine-protein phosphatase non-receptor type 11
- T-cell surface antigen CD2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0035556 (intracellular signal transduction), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: AT3G03270 protein (Adenine nucleotide alpha hydrolases-like superfamily protein) (Q8LFK2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MGKARTVGVGMDYSPTSKLALRWAAENLLEDGDTVILIHVQPQNADHTRKILFEETGSPLIPLEEFREVNLSKQYGLAYDPEVLDVLDTLSRAKKVKVVAKVYWGDPREKLCDAVENLKLDSIVLGSRGLGSLKRPNHNGFMIIMFDHSLVGLVSLDHDQSGLINMAEMGSSKSICWIRRNQERDSRWSFSDLLLDDHPLD
InterPro domains: - IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [3-145]
- IPR006016: UspA (domain) [5-135]
Interaction partners: - AT4g27450/F27G19_50
- At1g01170)
- AT3G11930 protein
- Tetratricopeptide repeat protein SKI3
- Aspartate aminotransferase, cytoplasmic isozyme 1
- Arginyl-tRNA--protein transferase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009620 (response to fungus), GO:0043207 (response to external biotic stimulus), GO:0002238 (response to molecule of fungal origin)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit 4L) (NADH-plastoquinone oxidoreductase subunit 4L) (P0C332)
Organism: Oryza sativa (Rice)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01456}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01456}.
Sequence: MMFEHVLFLSVYLFSIGIYGLITSRNMVRALICLELILNSINLNLVTFSDLFDSRQLKGDIFAIFVIALAAAEAAIGLSILSSIHRNRKSTRINQSNFLNN
InterPro domains: - IPR039428: NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like (family) [5-99]
- IPR001133: NADH-ubiquinone oxidoreductase chain 4L/K (family) [1-101]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006970 (response to osmotic stress), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0097305 (response to alcohol), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid), GO:0033993 (response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Trypanosoma glutamic acid/alanine-rich protein domain-containing protein (Q57YD8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MTRFTCFTAVVLLCMPFAVGKNNNLTLEQTVTLCNALKQFRGLKDAVRDLKYWITTESLKISNAKTRSDEYVTLAEDVLWENRNATDPVERAKRVASNVTEAAKKAETASIETEFRAENIEEIRSNRIAALERMLKEVAGHNSNWRVRSAAEKCKGAAESVSSDSLNGTLLELFSTLPEGASEGLEDDTRESSGELWKLEFVLYNVVTWRSVALKGESTVKELVEGTKASITRKYNLTLNQTQAVCLMVEQYRGLKGAVDAFTEQAVSRSAMVSKVEERSQADAKRPGGHMDQVKRAVAEVAKAVSKAQNVFKKVSRYARNLKSIRAHYLPLMENTLRKIAGNAADEKAKKAAEVCGETAWVVTPKSLDDMRKKLMDNFPNLSERLESDTRVVSHMLEDLNTSTQLITIASIAVRRKEVKLNKTMEVAGVASLIEFGEGRLSSMGSAASNKNHNLRLLLFSLTFTLVGLL
InterPro domains: - IPR031987: Trypanosoma glutamic acid/alanine-rich protein (domain) [28-413]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)