Protein: Carboxypeptidase N subunit 2 (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N large subunit) (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N regulatory subunit) (Q9DBB9)
Organism: Mus musculus (Mouse)
Function: The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Sequence: MFPGAWLCWVSLLLLARLTQPCPVGCDCFGREVFCSDEQLADIPPDIPPHITDIVFVETAFTTVRTRAFSGSPNLTKVVFLNTQVRHLEPDAFGGLPRLQDLEITGSPVSNLSAHIFSNLSSLEKLTLDFDRLAGLPEDLFCHMDILESLQLQGNQLRTLPGRLFQSLRDLRTLNLAQNLLTQLPKGAFQSLTGLQMLKLSNNMLARLPEGALGSLSSLQELFLDGNAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLFSSLHNLTFLSLKDNALRTLPEGLFAHNQGLLHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNAITDLPEHVFRNLEQLVKLSLDSNNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTNYDLFNLALLGNPWQCDCHLSYLTSWLRLYNNQISNTHTFCAGPAYLKGQLVPNLKQEQLICPVNPGHLSFRALGLDEGEPAGSWDLTVEGRAAHSQCAYSNPEGTVLLACEESRCRWLNIQLSSRDGSDSAAMVYNSSQEWGLRSSCGLLRVTVSIEAPAAGP
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [19-453]
- IPR050541: Leucine-rich repeat and transmembrane domain-containing protein (family) [227-447]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [21-53]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [96-383]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [395-446]
- IPR001611: Leucine-rich repeat (repeat) [147-383]
Interaction partners: - Carboxypeptidase N catalytic chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0050793 (regulation of developmental process), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0045595 (regulation of cell differentiation), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030510 (regulation of BMP signaling pathway), GO:0045669 (positive regulation of osteoblast differentiation), GO:0045667 (regulation of osteoblast differentiation), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030513 (positive regulation of BMP signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)