Protein: Probable glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (Q9Y105)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MAGDDLIAKFQALGMSEQKAKETLKNANVTKNLQLSLAAAGSATLSDGTGMLIYHMATKLKPQTADHLPLLVRYIVEHKLDNTQRVDAALEYLLKCGQSLNANIDLQALEKECGVGVVVTPEQIERTVQAKIKASYKEALLEQRYHFNSFKILQDVRGELKWADAKSVKAAIDVEIFDLLGPKTEADLKPQTKANDKPKAAKPKAEVTPAAQTAEAASDGATTISELMKTKVHFHAPGENFKADGYVVTEHTERLLKEHLARTGGKVHTRFPPEPNGILHIGHAKAININFGYAAAHDGVCYLRYDDTNPEKEEEKFFLAIKEMVEWLGYKPFKITYSSDNFQQLYEWAVVLINKGLAYVCHQKAEELKGFNPKPSPWRERPIEESLRLFEDMKRGKIDEGAATLRMKVTLEEGKMDPVAYRIKFISHHRTGSDWCIYPTYDYTHCLCDSLEDITHSLCTKEFQSRRSSYYWLCNALGIYCPVQWEYGRLNMNYALVSKRKIAKLITEQIVHDWDDPRLFTLTALRRRGFPAEAINNFCAQMGVTGAQIAVDPAMLEAAVRDVLNVTAPRRLVVLEPLKVTIKNFPHAAPVQLEVPDFPQNPQQGTHKITLDKVIYIEQGDFKLEPEKGYRRLAPKQSVGLRHAGLVISVDEIVKDPATGQVVELICTSQPAEQAEKPKAFVQWVSQPIQLEVRLYEQLFKHKNPEDPNEVPGGFLSDISEQSMSVVVAFADRALNQAKVYDKFQFERIGFFSVDPDTSANHLVFNRTVGLKEDAGKK
InterPro domains: - IPR007639: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal (domain) [5-165]
- IPR020058: Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain (domain) [266-565]
- IPR020059: Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain (domain) [568-668]
- IPR000924: Glutamyl/glutaminyl-tRNA synthetase (family) [270-449]
- IPR049437: tRNA synthetases class I (E and Q), anti-codon binding domain (domain) [682-755]
- IPR007638: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain 2 (domain) [168-257]
- IPR001412: Aminoacyl-tRNA synthetase, class I, conserved site (conserved_site) [273-284]
- IPR050132: Glutamine/Glutamate--tRNA Ligase (family) [12-774]
- IPR042558: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 1 (homologous_superfamily) [2-117]
- IPR020056: Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal (homologous_superfamily) [572-774]
- IPR042559: Glutaminyl-tRNA synthetase, class Ib, non-specific RNA-binding domain, N-terminal, subdomain 2 (homologous_superfamily) [119-188]
- IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [231-571]
- IPR004514: Glutamine-tRNA synthetase (family) [267-775]
- IPR011035: Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily (homologous_superfamily) [568-774]
Interaction partners: - Lysine--tRNA ligase
- Probable arginine--tRNA ligase, cytoplasmic
- leucine--tRNA ligase
- Isoleucine--tRNA ligase, cytoplasmic
- Bifunctional glutamate/proline--tRNA ligase
- Methionine--tRNA ligase, cytoplasmic
- Aspartate--tRNA ligase, cytoplasmic
- Tyrosine--tRNA ligase
- AaRS-interacting multifunctional protein 1
- Glutamyl-tRNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016875 (ligase activity, forming carbon-oxygen bonds), GO:0004812 (aminoacyl-tRNA ligase activity), GO:0140101 (catalytic activity, acting on a tRNA)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0043038 (amino acid activation), GO:0010467 (gene expression), GO:0019752 (carboxylic acid metabolic process), GO:0016070 (RNA metabolic process), GO:0043043 (peptide biosynthetic process), GO:0006418 (tRNA aminoacylation for protein translation), GO:0043039 (tRNA aminoacylation), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)