Protein: Hybrid signal transduction histidine kinase M (EC 2.7.13.3) (Q54SK5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity).
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MSNYLNANSTENNNNNNNNNNNNNNNINNNFNTTDFKIVGNFNTPPIGSNNNNNNNNNSISTQSLQTINECNSGGEQSPKIKTNNNSYNTPVSSSTSTTGTNTTPMKSTPIHNSLQNIFKNANRSNLNNNNNNNNNNNNNNNNNNNNNNNNNSGCGSGSLNSVNNNNNNNNNNNNNSNNNNSNSNSNSNNNNNSNSNNNNNNSNSNAYPLKYYQHPQQSCSNLDSFENLSPLRQSSTLLNFSSNNNNNNNNNNNNNNNNSNNNSSNNNNKNNSSKNKVGGGNNKNNGGDDSAQFISSDNKYNTVGNETHHHHHHQLHNHRHSNVQGSSSPIKSSPKLISSQSLGNIFSQISPNIALTTNISPHGSPFSSSSSSRKSSSSPSFLNQNNQNNPNNQNNQNNSTSPHEKSFLNNSNDSFDYNDNSKRLRNRLTRNTGYSSTGSIGNSSSSSFYNNNNENSNIYSKIKHTRSSSGGNKPSPKYFQTSQAIYTPPYPQPYPQPPQLPPPSSSSSLSKENDNVDNNNTNNNNNNNNNNNNNNNNNNNESFFSSKGTMNLIHISLLSVLAFYIFLMVSKKFLFRVFQWNNNINSLFILIFSFHFIFSSILMFLLVVLLKMKKYSHSISQSARESLRNSRVIPSLLNFFLSDYIFLGLVLSGLVNILQVNLFFNPKDPLLNLDSISNISTAIEFLVVGIVLNFSHIPKKMYNSRYSEFRVSSSISPYFQDESYNVNNIINNDNKNKINDKSDNSNSITNNNNINNNIDNNNNSSSNTKINNDLNFDNNIKNNDINNNITNNNNNNNNNNNNNNNTNNNNNNNNNNSNNNNNNNNNNSNKNNNTNSNNNNNNSSNNNNTNNNKINDNKNNNNNNNNNNNNNNNNNNNNNNEEDDEEEKNDWSYSFQIFFTRIFLCLSITYTLIVLRLNYDPLNQFLQQSSSFGSGANGNSGGGNVNTIISPVQFQAPLATLLHFIQLVLLLVNYNRFRTNRFFSLILSTIFIEVSSWETFGLNSRLFESYIFEALLIRRWIRACSVGFPIVGIILDIYSGWMSINQSIKSIDQQNIMIVNRFNYLCSNVKKQEELTQYNSQFYIESMNQFKRLVQNTGSIISLIYDTDVQPNQEAYLSKFSSSYEQLSKLTKECLFYSEIKQLKRNDVENLSFVVSNLLEDLISTPSIRTQFEEKEIDLFYLIDKDVPLSLVGDSQKIKQILLKLITNSIKATYEGEVYIRVSLSSNLGVLKQQPIHHHRHHHRHHHHHHHHHHHHIIDDDDYDDDNDDDNNTEDSSSCCNIDELSDKIKDNQDENLELKKSNNDKIIENKENQENNNNNNNNNNNNNNNNNNNNNNSNNNTNININTNNNNDSNNNNCINNDLKNNNNNSNNNVNNNNNNINDSNNNNNSNNNNINNNINNNINNNNNIKKKKKKNEFTVYFSVIDSGSGIDPYSTNLLFQPFSLSSYNVNSTNTDGEFGLGLAICKQLSNLMNGEIKYETEMEKGSVFELQVPMKCDSISSITSSMNSTTNTTNHYPRIMNNQSSKFFANSKWGEGLKILVIDDNPNIGKVIAMHLEPFGFKVFQRTTFQSAIYFFNERNGDFNLILLDPLIPSLVIDEIKQMKQDSSNIIKNPPLVIMCTAKLRKSLNVDNVHYLYKPIKREQLTVLSQLLPNTSTINPIYSNQNLNNSGSSNGGGGGGGGGGGGGGGGGSGSSNIDFNKTKLGGSNISTGIGNSGLINSNNIPTPVNTPSNIIPNLLSCQSLLTSLNNANIPQLTNDIGITNNNINNNSLMFTTPNSTLSNNGITGLDNNSNNDTGSIDNNSNISTNIDNNNDYFIRNNGIPPQNDMNTYNNYVLNHQQGVLPKSLSVPSTPLSYNMLPTNLNINAKRSSLQPLNENSVLPTNLTPPILSASPQSLLPMGNDINSILPNTQQSQIDLQSQIELQPLLQSTIIRNDRGGDILPDSTLEGQITNLSGNNSTISINPPLPETNNNTTTTTTTTQPKKSPILTSSNGSDKSEGSTGSNRSKSRISFLNSSNSGLLKNNLGEDIYCKGDQSEGIPIPKSERTSDSSSSSSSSDSHGQDDHSYRLEDFSISSPSSQSPLLDLSGTSGTSGTTNLANSGINSGSGSGGGDIINQNQLITSNQLFQQQLQQQQQPQQQQPPGTPTISPSSSFPLLPIPRDIINSSGASSGIKVKSSTSIPDYVQVSPRRFSGSSTGSGSSVASPQLLSTSNQLNNNINNLNLNSNNNNNNNNNNNNNNNTNNDNNNNNDNNYNVNILLVEDNLVNAKIAMTVLRKHNFRVELSKNGQLAMERIKQSHSSFDLILMDIHMPVMDGITCSKLTRKFETEHGLKHLPIIALTADATTGHKNLCLEAGCNEFMSKPLDYALLISLLKKLVFNKDQ
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [1113-1514]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [1194-1499]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [1540-2383]
- IPR005467: Histidine kinase domain (domain) [1093-1499]
- IPR004358: Signal transduction histidine kinase-related protein, C-terminal (domain) [1422-1496]
- IPR011006: CheY-like superfamily (homologous_superfamily) [1538-2382]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0099120 (socially cooperative development), GO:0048856 (anatomical structure development), GO:0030587 (sorocarp development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)