wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Tektin-4 (Q8WW24)
Organism: Homo sapiens (Human)
Function: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Contributes to normal sperm motility (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q149S1}. Note=Found in the abaxial (convex) surface of outer dense fibers in sperm flagella. {ECO:0000250|UniProtKB:Q149S1}.
Sequence: MAQTVPPCELPCKEYDVARNTGAYTSSGLATASFRTSKYLLEEWFQNCYARYHQAFADRDQSERQRHESQQLATETQALAQRTQQDSTRTVGERLQDTHSWKSELQREMEALAAETNLLLAQKQRLERALDATEVPFSITTDNLQCRERREHPNLVRDHVETELLKEAELIRNIQELLKRTIMQAVSQIRLNREHKETCEMDWSDKMEAYNIDETCGRHHSQSTEVQAHPYSTTFQESASTPETRAKFTQDNLCRAQRERLASANLRVLVDCILRDTSEDLRLQCDAVNLAFGRRCEELEDARYKLHHHLHKTLREITDQEHNVAALKQAIKDKEAPLHVAQTRLYLRSHRPNMELCRDAAQFRLLSEVEELNMSLTALREKLLEAEQSLRNLEDIHMSLEKDIAAMTNSLFIDRQKCMAHRTRYPTILQLAGYQ
InterPro domains: - IPR048256: Tektin-like (family) [44-426]
- IPR000435: Tektins (family) [30-434]
Interaction partners: - Tektin-1
- Tektin-2
- Cilia- and flagella-associated protein 144
- Cilia- and flagella-associated protein 52
- EF-hand domain-containing family member C2
- EF-hand domain-containing protein 1
- Protein Flattop
- Piercer of microtubule wall 1 protein
- Tektin-3
- Tubulin beta-4B chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0007017 (microtubule-based process), GO:0032504 (multicellular organism reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0044706 (multi-multicellular organism process), GO:0060378 (regulation of brood size), GO:0048870 (cell motility), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0007018 (microtubule-based movement), GO:0003341 (cilium movement), GO:0060285 (cilium-dependent cell motility), GO:0060294 (cilium movement involved in cell motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: T-box transcription factor mls-1 (Mesodermal lineage specification protein 1) (O17212)
Organism: Caenorhabditis elegans
Function: Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells. Furthermore, may function with the transcriptional corepressor unc-37.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Sequence: MNRNFSIDAILARKPVEKRKQIITKDNCKFIRVFLQSSNLWRRFHNLGTEMIVTKSGRRMFPTLSVIIAGLDPVKSYVVMVDLECIEMKRFRYSFHQSKWISTGPGESELPSRMFVHTDSPARGAHWMRAPVSFDKMKLTNNQLDNNGHIIVNSMHKYRPRVHIIEQDDSQKRHTFSFEETEFIAVTAYQNHRITSLKIESNPFAKGFRECEVQGIEMNSVGGMTGGPAFQSVFPLIFPYFANLASNMNVNK
InterPro domains: - IPR046360: T-box transcription factor, DNA-binding domain (domain) [30-215]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [31-210]
- IPR001699: T-box transcription factor (family) [29-209]
- IPR036960: T-box superfamily (homologous_superfamily) [17-210]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [40-59]
Interaction partners: - Homeobox protein mls-2
- Transcription factor unc-37
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0010171 (body morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0010172 (embryonic body morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Brain-derived neurotrophic factor (proBDNF) (K4MQC6)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Secreted {ECO:0000256|RuleBase:RU364086}.
Sequence: MTILFLTMVISYFSRMKAAPMKEASVRGHGSLAYPGLRTHGTLESLTGPNAGSRGLTSLADTFEHVIEELLDEDQDIQPSEENKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSTSEWVTAAEKKTAVDMSGATVTVLEKVPVPKGQLKQYFYETKCNPKGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDNKKRVGWRFIRIDTSCVCTLTIKRGR
InterPro domains: - IPR020430: Brain-derived neurotrophic factor (family) [10-194]
- IPR020408: Nerve growth factor-like (family) [1-246]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [126-246]
- IPR019846: Nerve growth factor conserved site (conserved_site) [194-207]
- IPR002072: Nerve growth factor-related (domain) [132-243]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Leucine zipper putative tumor suppressor 3 (ProSAP-interacting protein 1) (ProSAPiP1) (Q8K1Q4)
Organism: Rattus norvegicus (Rat)
Function: May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.
Subcellular location: Synapse {ECO:0000269|PubMed:27252646}. Postsynaptic density {ECO:0000269|PubMed:16522626, ECO:0000269|PubMed:27252646}. Cell projection, dendritic spine {ECO:0000269|PubMed:16522626}. Cell projection, dendrite {ECO:0000269|PubMed:16522626}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16522626}. Note=Rather found at excitatory than inhibitory synapses (PubMed:27252646). {ECO:0000269|PubMed:16522626, ECO:0000269|PubMed:27252646}.
Sequence: MAPADLASEGPKLEDPPAPHLFGKCPSGLIMANVETLPVRADPGRDPLLAFAPRPAELGPPDPRLTMGSVGGGVTHAQEFPMKSVGTRTGGGGSQGSFPGPRSSGSGTNRERPGPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLEKSRTMTPAGGSGGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTPGYSSGGGGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSQEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAACQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVDAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSRTPTPQHGEEEKAWTPSRLERIESTEI
InterPro domains: - IPR045329: Leucine zipper putative tumor suppressor (family) [31-542]
Interaction partners: - SH3 and multiple ankyrin repeat domains protein 3
- Signal-induced proliferation-associated 1-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0008284 (positive regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation), GO:0043627 (response to estrogen)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0032279 (asymmetric synapse)
Protein: chitinase (EC 3.2.1.14) (Q7SYA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MTGLIFLAGISLALCQCGLASQLACYFANWSQYRPDVGKYMPSNVDPHLCTHLIYAFSVINIKNKLATSEWNDETLYQSFNALKQSNPNLKTLLAVGTLNLGSTQFSRMVSTPQKRQTFIESSIKFLRTHGFDGLDLDWEYPGSGESPPEDKHRFTLLCKELLKAYQAESKATRRPRLMLTAAVAARKGIIDAGYEIAEVSKYLDFINIMTYDFHGSWENVTGHNSPLYRDSRDTGDQIYYNTDFAMTYWRDQGAPVEKLRMGFAAYGRTFCLSSAVNGLGAPVSGPASAGTYTREAGYWSYYEICTFLQRASVEQIADQKVPYATEGLNWVGFDDQKSYETKVDYLKEKGFGGAFVWSLDLDDFSGQFCGQGKYPLIGHLHTLLNISNTEFRHLPKTIKSGGASATGNIVTTTPIVKTVTSGSDFCAGGLVGIFANPDNPMTFIQCANGRTFIQNCPAKTVFDPDCSCCNWPKN
InterPro domains: - IPR036508: Chitin binding domain superfamily (homologous_superfamily) [421-475]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [23-385]
- IPR050314: Glycosyl Hydrolase Family 18 (family) [21-402]
- IPR011583: Chitinase II/V-like, catalytic domain (domain) [21-363]
- IPR001579: Glycosyl hydrolase family 18, active site (active_site) [132-140]
- IPR001223: Glycoside hydrolase family 18, catalytic domain (domain) [21-388]
- IPR002557: Chitin binding domain (domain) [424-475]
- IPR029070: Chitinase insertion domain superfamily (homologous_superfamily) [267-335]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0030246 (carbohydrate binding), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0004568 (chitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0009581 (detection of external stimulus), GO:0009887 (animal organ morphogenesis), GO:0048513 (animal organ development), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0048568 (embryonic organ development), GO:0050982 (detection of mechanical stimulus), GO:0007600 (sensory perception), GO:0050910 (detection of mechanical stimulus involved in sensory perception of sound), GO:0050954 (sensory perception of mechanical stimulus), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Lymphocyte antigen 6E (Ly-6E) (Stem cell antigen 2) (Thymic shared antigen 1) (TSA-1) (Q64253)
Organism: Mus musculus (Mouse)
Function: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response.
Subcellular location: Cell membrane {ECO:0000269|PubMed:9575182}; Lipid-anchor, GPI-anchor {ECO:0000305}.
Sequence: MSATSNMRVFLPVLLAALLGMEQVHSLMCFSCTDQKNNINCLWPVSCQEKDHYCITLSAAAGFGNVNLGYTLNKGCSPICPSENVNLNLGVASVNSYCCQSSFCNFSAAGLGLRASIPLLGLGLLLSLLALLQLSP
InterPro domains: - IPR016054: Ly-6 antigen/uPA receptor-like (domain) [27-118]
- IPR045860: Snake toxin-like superfamily (homologous_superfamily) [25-107]
- IPR051110: Ly-6/neurotoxin-like and GPI-anchored (family) [7-133]
- IPR035076: Snake toxin/toxin-like (domain) [27-105]
Interaction partners: - Lymphocyte antigen 6A-2/6E-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0010033 (response to organic substance), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0014070 (response to organic cyclic compound), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:0035634 (response to stilbenoid), GO:1903131 (mononuclear cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: BTB domain-containing protein (Voltage-gated K+ channel isoform 1) (G5EEK7)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MDSEYRIILNVGGVRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPLDVCGPLFEEELKYWGLDSNECEPCCWMTLSGTRDTQDVLKTLDELDIEVDQTEGPELYKRFGWEDDYHNDSLSAWQKIKPRIWRLFDEPNSSRSAQFIAAISVFFLITAIIVFCLKTHPGLRIPELAPFGNFSRNHRSTSSRIHPAQINIDKANSRPHPTFMYIETICNIWFTIEILARFSSCPSRFEYLRAPVNIIDIVATLTFYIDLLSSMFGATADLEFFSIIRIMRLFKLTHHNSGLKILMHTFRASAKELMLLVFFLVLGVVVFASLVYYAERVESNEDNQFVSIPIGLWWAIVTMTTIGYGDITPHTYLGRLIGSICALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLSMDQVAQHVKHAPVRNSNGPTQRKNMENTPLVSNNHTPPHTLI
InterPro domains: - IPR003974: Potassium channel, voltage dependent, Kv3 (family) [48-439]
- IPR028325: Voltage-gated potassium channel (family) [6-451]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [141-310]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [7-97]
- IPR000210: BTB/POZ domain (domain) [5-105]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [1-115]
- IPR003968: Potassium channel, voltage dependent, Kv (family) [47-411]
- IPR005821: Ion transport domain (domain) [170-423]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0006811 (monoatomic ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Clarin-3 (Transmembrane protein 12) (Usher syndrome type-3A-like protein 1) (Q8NCR9)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MPTTKKTLMFLSSFFTSLGSFIVICSILGTQAWITSTIAVRDSASNGSIFITYGLFRGESSEELSHGLAEPKKKFAVLEILNNSSQKTLHSVTILFLVLSLITSLLSSGFTFYNSISNPYQTFLGPTGVYTWNGLGASFVFVTMILFVANTQSNQLSEELFQMLYPATTSKGTTHSYGYSFWLILLVILLNIVTVTIIIFYQKARYQRKQEQRKPMEYAPRDGILF
InterPro domains: - IPR026748: Clarin (family) [1-226]
Interaction partners: - Transmembrane and immunoglobulin domain-containing protein 1
- Voltage-dependent calcium channel gamma-2 subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0003008 (system process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0050890 (cognition), GO:0007612 (learning), GO:0030177 (positive regulation of Wnt signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:1901222 (regulation of NIK/NF-kappaB signaling), GO:0032006 (regulation of TOR signaling), GO:0032008 (positive regulation of TOR signaling), GO:0008306 (associative learning), GO:1904263 (positive regulation of TORC1 signaling), GO:1903432 (regulation of TORC1 signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0042995 (cell projection), GO:0030027 (lamellipodium), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0098858 (actin-based cell projection), GO:0005902 (microvillus)
Protein: LRR and NB-ARC domains-containing disease resistance protein (Q2V4G0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MGSCFSLQVSDQTLNRIFNCLIGKSYIRTLEKNLRALQREMEDLRAIQHEVQNKVARDEARHQRRLEAVQVWLDRVNSVDIECKDLLSVTPVELQKLCLCGLCSKYVCSSYKYGKKVFLLLEEVKKLNSEGNFDEVSQPPPRSEVEERPTQPTIGQEDMLEKAWNRLMEDGVGIMGLHGMGGVGKTTLFKKIHNKFAEIGGTFDIVIWIVVSKGVMISKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGIPYPSEVNKCKVAFTTRSREVCGEMGDHKPMQVNCLEPEDAWELFKNKVGDNTLSSDPVIVELAREVAQKCRGLPLALNVIGETMSSKTMVQEWEHAIHVFNTSAAEFSDMQNKILPILKYSYDSLGDEHIKSCFLYCALFPEDGEIYNEKLIDYWICEGFIGEDQVIKRARNKGYAMLGTLTRANLLTKVGTYYCVMHDVVREMALWIASDFGKQKENFVVQAGVGLHEIPKVKDWGAVRKMSLMDNDIEEITCESKCSELTTLFLQSNKLKNLPGAFIRYMQKLVVLDLSYNRDFNKLPEQISGLVSLQFLDLSNTSIEHMPIGLKELKKLTFLDLTYTDRLCSISGISRLLSLRLLRLLGSKVHGDASVLKELQQLQNLQELAITVSAELISLDQRLAKLISNLCIEGFLQKPFDLSFLASMENLSSLRVENSYFSEIKCRESETESSYLRINPKIPCFTNLSRLEIMKCHSMKDLTWILFAPNLVVLLIEDSREVGEIINKEKATNLTSITPFLKLEWLILYNLPKLESIYWSPLPFPVLLTMDVSNCPKLRKLPLNATSVSKVEEFEIHMYPPPEQENELEWEDDDTKNRFLPSIKPVIISFNLLCLSYLYFLLMFLSRLA
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [480-850]
- IPR055414: Disease resistance R13L4/SHOC-2-like, LRR domain (domain) [513-774]
- IPR042197: Apoptotic protease-activating factors, helical domain (homologous_superfamily) [308-395]
- IPR050905: Plant disease resistance NBS-LRR (family) [25-832]
- IPR002182: NB-ARC (domain) [156-397]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [134-411]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [396-479]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0006952 (defense response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)