Protein: ATP-sensitive inward rectifier potassium channel 11 (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11) (Q61743)
Organism: Mus musculus (Mouse)
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation (By similarity).
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q14654}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14654}.
Sequence: MLSRKGIIPEEYVLTRLAEDPAEPRYRTRERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMVWWLIAFAHGDLAPGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVAPLIIYHVIDSNSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDRSLLDALTLASSRGPLRKRSVAVAKAKPKFSISPDSLS
InterPro domains: - IPR003279: Potassium channel, inwardly rectifying, Kir6.2 (family) [20-390]
- IPR040445: Potassium channel, inwardly rectifying, transmembrane domain (domain) [36-173]
- IPR016449: Potassium channel, inwardly rectifying, Kir (family) [6-384]
- IPR013518: Potassium channel, inwardly rectifying, Kir, cytoplasmic (homologous_superfamily) [34-347]
- IPR041647: Inward rectifier potassium channel, C-terminal (domain) [181-353]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [156-353]
Interaction partners: - ATP-binding cassette sub-family C member 9
- ATP-binding cassette sub-family C member 8
- ATP-sensitive inward rectifier potassium channel 8
- Gamma-aminobutyric acid type B receptor subunit 2
- Gamma-aminobutyric acid type B receptor subunit 1
- Rap guanine nucleotide exchange factor 4
- Hexokinase-4
- Insulin-2
- Insulin-1
- Rap guanine nucleotide exchange factor 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity), GO:0005242 (inward rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0065008 (regulation of biological quality), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0001508 (action potential), GO:0006812 (monoatomic cation transport), GO:0086001 (cardiac muscle cell action potential), GO:0030001 (metal ion transport), GO:0015693 (magnesium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0098793 (presynapse), GO:0044304 (main axon), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0043209 (myelin sheath), GO:1990351 (transporter complex), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0030315 (T-tubule), GO:0031975 (envelope), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0030141 (secretory granule), GO:0030673 (axolemma), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0032589 (neuron projection membrane), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0005739 (mitochondrion), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:1902495 (transmembrane transporter complex), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0031253 (cell projection membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0042383 (sarcolemma), GO:0001669 (acrosomal vesicle), GO:0098978 (glutamatergic synapse), GO:0043005 (neuron projection), GO:0031982 (vesicle), GO:0005911 (cell-cell junction), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0070852 (cell body fiber), GO:0044291 (cell-cell contact zone), GO:0034703 (cation channel complex), GO:0030424 (axon), GO:0034705 (potassium channel complex), GO:0014704 (intercalated disc)