Protein: Protein quaking-A (zqk) (Q6P0D0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9QYS9}. Nucleus {ECO:0000250|UniProtKB:Q9QYS9}.
Sequence: MVGEMEVKERPRPSPDYLMQLLNEKKLMTSLPNLCGIFTHLERLLDEEINRVRKDMYNDSVNGLVDKHPLELPEPVGPIVHLQEKLFVPVKEYPDYNFVGRILGPRGLTAKQLEAETGCKIMVRGRSSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDTQTRAEIKMRRAVEEVKKLLVPAAEGEDNLKKMQLMELAILNGTYRDTNIKAPTLAFSLAAAAAAAQGPRLIAAPPGQVLPPATLRPPTPAGTPIMNIIRPTQMATVLPNGTPTLVPPTPDAGIIYTTPYDYPYALAPTSLLEYPIEHSGVLGAMATKVRRHDSRVHPYQRIVTADRAATGN
InterPro domains: - IPR032377: STAR protein, homodimerisation region (domain) [11-61]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [72-213]
- IPR045071: KH domain-containing BBP-like (family) [9-295]
- IPR004087: K Homology domain (domain) [80-174]
- IPR055256: KHDC4/BBP-like, KH-domain type I (domain) [92-179]
- IPR032367: Protein quaking, putative nuclear localisation signal (domain) [312-341]
Interaction partners: - Mediator of RNA polymerase II transcription subunit 25
- Mediator of RNA polymerase II transcription subunit 15
- Mediator of RNA polymerase II transcription subunit 4
- Mediator of RNA polymerase II transcription subunit 24
- Mediator of RNA polymerase II transcription subunit 23
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 17
- Mediator of RNA polymerase II transcription subunit 27
- Mediator of RNA polymerase II transcription subunit 10
- Mediator of RNA polymerase II transcription subunit 29
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0016043 (cellular component organization), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0022607 (cellular component assembly), GO:0042692 (muscle cell differentiation), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0055001 (muscle cell development), GO:0097435 (supramolecular fiber organization), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0014866 (skeletal myofibril assembly), GO:0051146 (striated muscle cell differentiation), GO:0055002 (striated muscle cell development), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)