Protein: RNA 3'-terminal phosphate cyclase-like protein (Q9Y2P8)
Organism: Homo sapiens (Human)
Function: As part of the small subunit (SSU) processome, it plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). Activates BMS1 by promoting GDP/GTP exchange (By similarity). Does not have cyclase activity (By similarity)
Subcellular location: Nucleus, nucleolus
Sequence: MATQAHSLSYAGCNFLRQRLVLSTLSGRPVKIRKIRARDDNPGLRDFEASFIRLLDKITNGSRIEINQTGTTLYYQPGLLYGGSVEHDCSVLRGIGYYLESLLCLAPFMKHPLKIVLRGVTNDQVDPSVDVLKATALPLLKQFGIDGESFELKIVRRGMPPGGGGEVVFSCPVRKVLKPIQLTDPGKIKRIRGMAYSVRVSPQMANRIVDSARSILNKFIPDIYIYTDHMKGVNSGKSPGFGLSLVAETTSGTFLSAELASNPQGQGAAVLPEDLGRNCARLLLEEIYRGGCVDSTNQSLALLLMTLGQQDVSKVLLGPLSPYTIEFLRHLKSFFQIMFKIETKPCGEELKGGDKVLMTCVGIGFSNLSKTLK
InterPro domains: - IPR036553: RNA 3'-terminal phosphate cyclase, insert domain superfamily (homologous_superfamily) [184-284]
- IPR037136: RNA 3'-terminal phosphate cyclase domain superfamily (homologous_superfamily) [10-343]
- IPR016443: RNA 3'-terminal phosphate cyclase type 2 (family) [4-372]
- IPR013791: RNA 3'-terminal phosphate cyclase, insert domain (domain) [183-287]
- IPR013792: RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (homologous_superfamily) [11-234]
- IPR020719: RNA 3'-terminal phosphate cyclase-like, conserved site (conserved_site) [157-167]
- IPR000228: RNA 3'-terminal phosphate cyclase (family) [7-365]
- IPR023797: RNA 3'-terminal phosphate cyclase domain (domain) [10-341]
Interaction partners: - Bystin
- U3 small nucleolar RNA-associated protein 4 homolog
- WD repeat-containing protein 43
- U3 small nucleolar RNA-associated protein 18 homolog
- U3 small nucleolar ribonucleoprotein protein IMP4
- Ribosome biogenesis protein BMS1 homolog
- Nucleolar complex protein 4 homolog
- Neuroguidin
- U3 small nucleolar RNA-associated protein 6 homolog
- HEAT repeat-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)