Protein: Stromelysin-2 (SL-2) (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (O55123)
Organism: Mus musculus (Mouse)
Function: Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Sequence: MEPLAILALLSLPICSAYPLHGAVTQGHPSMDLAQQYLEKYYNFKKNEKQIFKRKDSSPVVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFYPFDGPGQSLAHAYPPGPGFYGDVHFDDDEKWTLAPSGTNLFLVAAHELGHSLGLFHSDKKESLMYPVYRFSTSPANFHLSQDDIEGIQSLYGAGPSSDATVVPVLSVSPRPETPDKCDPALSFDSVSTLRGEVLFFKDRYFWRRSHWNPEPEFHLISAFWPTLPSDLDAAYEAHNTDSVLIFKGSQFWAVRGNEVQAGYPKGIHTLGFPPTVKKIDAAVFEKEKKKTYFFVGDKYWRFDETRHVMDKGFPRQITDDFPGIEPQVDAVLHEFGFFYFFRGSSQFEFDPNARTVTHILKSNSWLLC
InterPro domains: - IPR036365: PGBD-like superfamily (homologous_superfamily) [33-97]
- IPR000585: Hemopexin-like domain (domain) [286-476]
- IPR018486: Hemopexin, conserved site (conserved_site) [328-343]
- IPR021158: Peptidase M10A, cysteine switch, zinc binding site (binding_site) [90-97]
- IPR006026: Peptidase, metallopeptidase (domain) [105-265]
- IPR002477: Peptidoglycan binding-like (domain) [29-87]
- IPR021190: Peptidase M10A (family) [2-476]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [20-269]
- IPR001818: Peptidase M10, metallopeptidase (domain) [108-264]
- IPR018487: Hemopexin-like repeats (repeat) [286-476]
- IPR033739: Peptidase M10A, catalytic domain (domain) [108-264]
- IPR036375: Hemopexin-like domain superfamily (homologous_superfamily) [282-476]
Interaction partners: - Stromelysin-1
- Metalloproteinase inhibitor 2
- Metalloproteinase inhibitor 1
- Fibronectin
- Metalloproteinase inhibitor 3
- Matrilysin
- Stromelysin-3
- Collagenase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044706 (multi-multicellular organism process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0001503 (ossification), GO:0023051 (regulation of signaling), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:1901700 (response to oxygen-containing compound), GO:0001817 (regulation of cytokine production), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0007283 (spermatogenesis), GO:0031348 (negative regulation of defense response), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0002831 (regulation of response to biotic stimulus), GO:0007565 (female pregnancy), GO:0042127 (regulation of cell population proliferation), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0031347 (regulation of defense response), GO:0050687 (negative regulation of defense response to virus), GO:0045089 (positive regulation of innate immune response), GO:1901565 (organonitrogen compound catabolic process), GO:0045088 (regulation of innate immune response), GO:0006508 (proteolysis), GO:0071310 (cellular response to organic substance), GO:0030163 (protein catabolic process), GO:0048545 (response to steroid hormone), GO:1901699 (cellular response to nitrogen compound), GO:0032675 (regulation of interleukin-6 production), GO:0030334 (regulation of cell migration), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0036211 (protein modification process), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0043412 (macromolecule modification), GO:0010243 (response to organonitrogen compound), GO:0050727 (regulation of inflammatory response), GO:0033993 (response to lipid), GO:0050688 (regulation of defense response to virus), GO:0014070 (response to organic cyclic compound), GO:1903556 (negative regulation of tumor necrosis factor superfamily cytokine production), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0007005 (mitochondrion organization), GO:0031960 (response to corticosteroid), GO:0032868 (response to insulin), GO:0070647 (protein modification by small protein conjugation or removal), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0032720 (negative regulation of tumor necrosis factor production), GO:0071383 (cellular response to steroid hormone stimulus), GO:0032680 (regulation of tumor necrosis factor production), GO:0032869 (cellular response to insulin stimulus), GO:0051384 (response to glucocorticoid), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071549 (cellular response to dexamethasone stimulus), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)