Protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2) (O88704)
Organism: Mus musculus (Mouse)
Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11459060, ECO:0000269|PubMed:22006928, ECO:0000269|PubMed:9630217}; Multi-pass membrane protein {ECO:0000269|PubMed:22006928}.
Sequence: MEGGGKPNSASNSRDDGNSVFPSKAPATGPVAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQQQLPQSQVQQTQTQTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTKEVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVAAVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNTDPDAEKPRFASNL
InterPro domains: - IPR051413: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (family) [76-678]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [456-592]
- IPR013621: Ion transport N-terminal (domain) [87-130]
- IPR000595: Cyclic nucleotide-binding domain (domain) [464-580]
- IPR018488: Cyclic nucleotide-binding, conserved site (conserved_site) [491-507]
- IPR003938: Potassium channel, voltage-dependent, EAG/ELK/ERG-like (family) [126-550]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [390-580]
- IPR005821: Ion transport domain (domain) [132-392]
Interaction partners: - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
- PEX5-related protein
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005217 (intracellular ligand-gated monoatomic ion channel activity), GO:0043855 (cyclic nucleotide-gated monoatomic ion channel activity), GO:0005221 (intracellular cyclic nucleotide activated monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0065008 (regulation of biological quality), GO:0019098 (reproductive behavior), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0055085 (transmembrane transport), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0035556 (intracellular signal transduction), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0098660 (inorganic ion transmembrane transport), GO:0048731 (system development), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0030534 (adult behavior), GO:0034220 (monoatomic ion transmembrane transport), GO:0071695 (anatomical structure maturation), GO:0098655 (monoatomic cation transmembrane transport), GO:0022008 (neurogenesis), GO:0042551 (neuron maturation), GO:0098662 (inorganic cation transmembrane transport), GO:0007399 (nervous system development), GO:0008344 (adult locomotory behavior), GO:0060179 (male mating behavior), GO:0006811 (monoatomic ion transport), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0019932 (second-messenger-mediated signaling), GO:0006812 (monoatomic cation transport), GO:0048699 (generation of neurons), GO:0016322 (neuron remodeling), GO:0035725 (sodium ion transmembrane transport), GO:0120036 (plasma membrane bounded cell projection organization), GO:0019722 (calcium-mediated signaling), GO:0007605 (sensory perception of sound), GO:0030001 (metal ion transport), GO:0009605 (response to external stimulus), GO:0006813 (potassium ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0044306 (neuron projection terminus), GO:0043198 (dendritic shaft), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0032589 (neuron projection membrane), GO:0043025 (neuronal cell body), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0032590 (dendrite membrane), GO:0016323 (basolateral plasma membrane), GO:0097440 (apical dendrite), GO:0030424 (axon)