Protein: Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3) (P18596)
Organism: Rattus norvegicus (Rat)
Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q93084}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q93084}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q93084}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q93084}.
Sequence: MEEAHLLSAADVLRRFSVTAEGGLTLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAIPDPRAVNQDKKNMLFSGTNIASGKALGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGACRLHEFTISGTTYTPEGEVRQGEQLVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLKGLSRVERAGACNSVIKQLMQKEFTLEFSRDRKSMSVYCTPTRADPKAQGSKMFVKGAPESVIERCSSVRVGSRTVPLSATSREHILAKIRDWGSGSHTLRCLALATRDTPPRKEDMQLDDCSQFVQYETGLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRNPREALISGWLFFRYLAIGVYVGLATVAAATWWFLYDAEGPQVTFHQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQMSLPVILLDEALKYLSRHHVDEKKDLK
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [134-237]
- IPR001757: P-type ATPase (family) [93-786]
- IPR005782: P-type ATPase, subfamily IIA, SERCA-type (family) [53-855]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [356-602]
- IPR036412: HAD-like superfamily (homologous_superfamily) [585-749]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [330-753]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [351-357]
- IPR023214: HAD superfamily (homologous_superfamily) [346-745]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [784-987]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [3-77]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [2-991]
Interaction partners: - Phospholamban
- Histidine rich calcium binding protein
- Calcium-transporting ATPase
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Histone acetyltransferase KAT5
- RAR-related orphan receptor A
- Sarcolipin
- Stromal interaction molecule 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0036094 (small molecule binding), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0140358 (P-type transmembrane transporter activity), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0000166 (nucleotide binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0032553 (ribonucleotide binding), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017076 (purine nucleotide binding), GO:0005338 (nucleotide-sugar transmembrane transporter activity), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0032555 (purine ribonucleotide binding), GO:0046872 (metal ion binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0046873 (metal ion transmembrane transporter activity), GO:0030554 (adenyl nucleotide binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0009719 (response to endogenous stimulus), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:1901698 (response to nitrogen compound), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0071702 (organic substance transport), GO:0090257 (regulation of muscle system process), GO:0006811 (monoatomic ion transport), GO:0070588 (calcium ion transmembrane transport), GO:0006937 (regulation of muscle contraction), GO:0006812 (monoatomic cation transport), GO:0006816 (calcium ion transport), GO:0030001 (metal ion transport), GO:0070296 (sarcoplasmic reticulum calcium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043227 (membrane-bounded organelle), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle)