Protein: Syndecan 2 (E5RHU3)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKK
InterPro domains: - IPR001050: Syndecan (family) [51-145]
- IPR027789: Syndecan/Neurexin domain (domain) [109-145]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0023057 (negative regulation of signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0010632 (regulation of epithelial cell migration), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0010646 (regulation of cell communication), GO:0008285 (negative regulation of cell population proliferation), GO:0010633 (negative regulation of epithelial cell migration), GO:0009966 (regulation of signal transduction), GO:0022603 (regulation of anatomical structure morphogenesis), GO:1901343 (negative regulation of vasculature development), GO:0030334 (regulation of cell migration), GO:1902532 (negative regulation of intracellular signal transduction), GO:0030334 (regulation of cell migration), GO:0010596 (negative regulation of endothelial cell migration), GO:0050678 (regulation of epithelial cell proliferation), GO:1902531 (regulation of intracellular signal transduction), GO:0030336 (negative regulation of cell migration), GO:0016525 (negative regulation of angiogenesis), GO:0043408 (regulation of MAPK cascade), GO:1903670 (regulation of sprouting angiogenesis), GO:0001936 (regulation of endothelial cell proliferation), GO:0043409 (negative regulation of MAPK cascade), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005788 (endoplasmic reticulum lumen), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0005796 (Golgi lumen), GO:0005764 (lysosome), GO:0043202 (lysosomal lumen)