wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Wdr36 protein (Q6NSU4)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: PRVRGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLNVTMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPPDYVPSIVMLPGTCQTQGMEDLEEKTEPSDEMIEYESPEQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIPTVPGLVPRFAVPEPSSDPQQSKVVNLGILAQKSNFYLKLEEGLLNNQYEAALNLLKELGPSGIETELRNLSPDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLALFLKLHLRTLPSEPALLEELVKLSSQVEKDWTHLQSLFNQSMCVLNYIKSAFL
InterPro domains: - IPR001680: WD40 repeat (repeat) [7-36]
- IPR019775: WD40 repeat, conserved site (conserved_site) [19-33]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [4-75]
- IPR007319: Small-subunit processome, Utp21 (domain) [127-329]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [4-99]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0050793 (regulation of developmental process), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0048871 (multicellular organismal-level homeostasis), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0060249 (anatomical structure homeostasis), GO:0048638 (regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0061387 (regulation of extent of cell growth), GO:0030516 (regulation of axon extension), GO:0032535 (regulation of cellular component size), GO:0001895 (retina homeostasis), GO:0008361 (regulation of cell size)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 (Q8BZV2)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MTAVPLVTILYVLVNISYLLVMSPSEILSSDAIAVIWGDRVLGSWAWLVPLAVALSTFGTVNGGFFSGSRVCYAAAREGHMPQLMSMIHVNRLTPAPAQIFTTAVALLLVIPGNFSTFVNLLSFLSWLTYGTTFACLLYLRIKTKNLPHTYKVPTFIPAIMLLVSLYLVLAPIIDHPQIEFLYIFLFVLSGFPVYFLLFHFQCQFKCIQTATMHLQLLLEVAPTTKDH
InterPro domains: - IPR002293: Amino acid/polyamine transporter I (family) [3-179]
- IPR050598: Cellular Amino Acid Transporter (family) [1-227]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Q7KUB0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDGQVIDEVINDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAKNAVAAK
InterPro domains: - IPR019818: Isocitrate/isopropylmalate dehydrogenase, conserved site (conserved_site) [269-288]
- IPR024084: Isopropylmalate dehydrogenase-like domain (domain) [9-400]
- IPR004790: Isocitrate dehydrogenase NADP-dependent (family) [1-411]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004448 (isocitrate dehydrogenase [NAD(P)+] activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0006082 (organic acid metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006102 (isocitrate metabolic process), GO:0072350 (tricarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ras-specific guanine nucleotide-releasing factor RalGPS1 (Ral GEF with PH domain and SH3-binding motif 1) (Ral guanine nucleotide exchange factor 2) (RalGEF 2) (RalA exchange factor RalGPS1) (Q5JS13)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10889189}. Cell membrane {ECO:0000269|PubMed:10889189}. Note=Associates with membranes through the PH domain.
Sequence: MYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE
InterPro domains: - IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [44-289]
- IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [46-290]
- IPR001849: Pleckstrin homology domain (domain) [431-545]
- IPR008937: Ras-like guanine nucleotide exchange factor (family) [21-295]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [14-304]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [432-557]
Interaction partners: - Growth factor receptor-bound protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0007264 (small GTPase mediated signal transduction), GO:0007265 (Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Lamin (Q90XD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}. Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}. Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
Sequence: METPGQKRSSRGGVTNVLSPTRISRLQEKEDLSNLNDRLAVYIDKVRSLEVENAGLRMRITESETEISRELSGMKAAYEAELADARKTLDSVAKERARLQLELSKVREDYKELKARNGKKEADLESALARLKDLESLLNSKDASLSTALGEKRTLEVEVRDLKAQLAKLEGSLNDAKKQLQDEMLRRVDAENRIQTLKEELEFQKNIYSEELRESKRRYESRVVEIDSGRQQDYESKLADALTDLRNQHEEQLRIYKEEIEKTYNSKLENARSSAERNSHLVGAAHEELQQTRVRMEGVSSQLSQLQKQLAAREAKIRELEEALSRERDILRRRLEDKEKEMAEMRQRMQQQLDEYQELLDIKLALDMEISAYRKLLEGEEERLRLSPSPPPARGVTVTRSSGSGSHTRVVQSSTSRTSSGSAKKRRLNDNDSDASSVVGGTVTRTRIFQQASASGRVTVDEVDLEGKFVRLNNKSDQDQSLGHWQVKRQIGSGTPIVYKFPPKFNLKAGQTVTIWAAGAGGTHSPPSDLVWKTQNSWGSGDLFQTTLISSSGEEMAMRKVTRTLFQDEEDDEMAAHSTCGDSEYNLRSRTVLCGSCGQPSDRNSSCVSASSGVSSASRSFSSGGGGGLTEAFVSPSHFIVSNDKPRQAGPKVDNCSIM
InterPro domains: - IPR001322: Lamin tail domain (domain) [446-563]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [370-378]
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [409-566]
- IPR039008: Intermediate filament, rod domain (domain) [27-384]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005200 (structural constituent of cytoskeleton)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0003013 (circulatory system process), GO:0008015 (blood circulation), GO:0003015 (heart process), GO:0060047 (heart contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Partner of bursicon (Bursicon subunit beta) (Q9VJS7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.
Subcellular location: Secreted {ECO:0000269|PubMed:15703293}.
Sequence: MHVQELLFVAAILVPQCLRALRYSQGTGDENCETLKSEIHLIKEEFDELGRMQRTCNADVIVNKCEGLCNSQVQPSVITPTGFLKECYCCRESFLKEKVITLTHCYDPDGTRLTSPEMGSMDIRLREPTECKCFKCGDFTR
InterPro domains: - IPR034441: Bursicon subunit beta (family) [7-141]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [22-139]
Interaction partners: - Bursicon
- Cardioactive peptide
- Rickets
- Eclosion hormone
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: rRNA-processing protein FCF2 (FAF1 copurifying factor 2) (Q12035)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:14562095}.
Sequence: MDQSVEDLFGALRDASASLEVKNSAKEQVSLQQEDVLQIGNNDDEVEIESKFQEIETNLKKLPKLETGFDALANKKKKKNVLPSVETEDKRKPNKSDKNDNDWFTLPKPDDNMRREVQRDLLLIKHRAALDPKRHYKKQRWEVPERFAIGTIIEDKSEFYSSRMNRKERKSTILETLMGDEASNKYFKRKYNEIQEKSTSGRKAHYKKMKEMRKKRR
InterPro domains: - IPR014810: Fcf2 pre-rRNA processing, C-terminal (domain) [96-190]
- IPR039883: Fcf2/DNTTIP2 (family) [19-216]
Interaction partners: - Something about silencing protein 10
- U3 small nucleolar RNA-associated protein 7
- Ribosome biogenesis protein BMS1
- U3 small nucleolar RNA-associated protein 11
- U3 small nucleolar ribonucleoprotein protein LCP5
- Protein BFR2
- Nucleolar protein 58
- rRNA-processing protein FCF1
- U3 small nucleolar RNA-associated protein 21
- KRR1 small subunit processome component
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0042273 (ribosomal large subunit biogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0030684 (preribosome), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030687 (preribosome, large subunit precursor), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Uncharacterized protein, isoform A (EC 1.-.-.-, EC 1.14.11.-, EC 1.14.11.33) (Uncharacterized protein, isoform B) (Q9VL81)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNTIRPCGCKGVRTCLSCEQDFHIAKTSLREQFQQLEAWSYCIQCDLLQRGWDTNHVQKDHENHKKDEGLPLPGILVQEEFLSVDEGAQLIADLDDLPWDISQSGRRKQNFGPKTNFKKRKLRLGSFAGFPRTTEYVQRRFEDVPLLRGFQTIEQCSLEYEPSKGASIDPHVDDCWIWGERVVTVNCLGDSVLTLTPYEVQQSGKYNLDLVASYEDELLAPLLTDDQLATFEGKVLRIPMPNLSLIVLYGPARYQFEHSVLREDVQERRVCVAYREFTPMYINGVDIQKGDPVREKSQIFWQIN
InterPro domains: - IPR037151: Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily (homologous_superfamily) [61-282]
- IPR032857: Alpha-ketoglutarate-dependent dioxygenase alkB homologue 4 (family) [2-284]
Interaction partners: - AlkB, isoform A)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0032451 (demethylase activity), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0140097 (catalytic activity, acting on DNA), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0002520 (immune system development), GO:0009791 (post-embryonic development), GO:0002164 (larval development), GO:0048513 (animal organ development), GO:0048534 (hematopoietic or lymphoid organ development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0035166 (post-embryonic hemopoiesis), GO:0048731 (system development), GO:0048732 (gland development), GO:0030097 (hemopoiesis), GO:0048542 (lymph gland development), GO:0035167 (larval lymph gland hemopoiesis), GO:0048569 (post-embryonic animal organ development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0070938 (contractile ring)
Protein: Mid1-interacting protein 1 (Gastrulation-specific G12-like protein) (Mid1-interacting G12-like protein) (Protein STRAIT11499) (Spot 14-related protein) (S14R) (Spot 14-R) (Q9NPA3)
Organism: Homo sapiens (Human)
Function: Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm {ECO:0000250|UniProtKB:Q9CQ20}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQ20}. Note=Associated with microtubules. {ECO:0000250|UniProtKB:Q9CQ20}.
Sequence: MMQICDTYNQKHSLFNAMNRFIGAVNNMDQTVMVPSLLRDVPLADPGLDNDVGVEVGGSGGCLEERTPPVPDSGSANGSFFAPSRDMYSHYVLLKSIRNDIEWGVLHQPPPPAGSEEGSAWKSKDILVDLGHLEGADAGEEDLEQQFHYHLRGLHTVLSKLTRKANILTNRYKQEIGFGNWGH
InterPro domains: - IPR053719: Lipogenesis and Microtubule Stabilization Superfamily (homologous_superfamily) [1-178]
- IPR009786: Spot 14 family (family) [1-180]
Interaction partners: - Thyroid hormone-inducible hepatic protein
- E3 ubiquitin-protein ligase Midline-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Protein FRIGIDA-ESSENTIAL 1 (Zinc finger CCCH domain-containing protein 27) (AtC3H27) (Q84VG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional activator involved in the FRIGIDA-mediated vernalization pathway, but not in the autonomous flowering pathway. Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression. Required for the stabilization of the FRI-C complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:16291783}.
Sequence: MSDSDMDIDDDEVEQKVQVHTIVRESELFDKPPIQASNSHNDVKRHSVTTPLDEQSKIIKEQAFAQDNGTLPRFPAPGIPPRSFFTGGGGNEPEQKRAALPCKFFAKGWCFNGVSCKFLHVKENSNCTSQQLAENSMAGNGGIRSDLERRILDSREGVRVSQLSENGVTSLPTREDISFMNPQRVFSSMSFVNPPGSQRVFPFNNEMRFMPSFENIRRESLKQTYGADFTDNRSLVINNANSFALRSSFVHEHRPSISSYLKTDMGSAGPAWTGSLSSSVPMNDRASTVGDFENGNSLSGSGSLPTLQGVAVSSDKGAEANTTSTKKKVSSDDWEPSEPFKASFTIPPYILPSSDALYDPFTDIENLGDRPLNDSLSSKGEHARKSSCQQKDGDSASGPQARDCKNDDKSSSCSQNQHQETVARSLEAHGVVEGVATSVVDQNDTATPSKEISSATAAENRVVLKRIKPAGHDSWHRSDGSSYKKTKKSDEIDGEVRSDAGMKVMRLFRTAVVETIKEMLKPLWREGRLTKDVHNMIVKKAAEKVVGAAVQFHQVPTDTESVDQYLGLSGTRIVKLVEGYVEKYGKP
InterPro domains: - IPR000571: Zinc finger, CCCH-type (domain) [96-123]
- IPR052650: Zinc finger CCCH domain-containing protein (family) [81-585]
- IPR036855: Zinc finger, CCCH-type superfamily (homologous_superfamily) [96-120]
Interaction partners: - FRIGIDA-like protein 1
- Protein SUPPRESSOR OF FRI 4
- Inactive protein FRIGIDA
- Inactive FRIGIDA-like protein 2
- Protein FLX-like 4
- Protein FLC EXPRESSOR
- Transcription initiation factor TFIID subunit 14
- Zinc finger CCCH domain-containing protein 44
- Zinc finger CCCH domain-containing protein 6
- Zinc finger CCCH domain-containing protein 55
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0061982 (meiosis I cell cycle process), GO:0016043 (cellular component organization), GO:0045132 (meiotic chromosome segregation), GO:0007059 (chromosome segregation), GO:0140013 (meiotic nuclear division), GO:0045143 (homologous chromosome segregation), GO:0098813 (nuclear chromosome segregation), GO:0007129 (homologous chromosome pairing at meiosis), GO:0006996 (organelle organization), GO:0007127 (meiosis I), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)