Protein: Aspartate protease (Q59U59)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Vacuole
Sequence: MQLSLSALTTVALALTSSLVDAKAHSIKLSKLSNEETLDASNFQEYTNSLANKYLNLFNTAHGNPSNFGLQHVLTNQEAEIPFVTPKKGGKYDAPLTNYLNAQYFTEIQIGTPGQPFKVILDTGSSNLWVPSQDCTSLACFLHAKYDHDASSTYKVNGSEFSIQYGSGSMEGYISQDVLTIGDLVIPGQDFAEATSEPGLAFAFGKFDGILGLAYDTISVNHIVPPIYNAINQGLLEKPQFGFYLGSTDKDENDGGLATFGGYDASLFQGKITWLPIRRKAYWEVLFEGIGLGDEYAELHKTGAAIDTGTSLITLPSSLAEIINAKIGATKSWSGQYQVDCAKRDSLPDLTLTFAGYNFTLTPYDYILEVSGSCISVFTPMDFPQPIGDLAIVGDAFLRKYYSIYDLDKNAVGLAPSKV
InterPro domains: - IPR001969: Aspartic peptidase, active site (active_site) [119-315]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [71-417]
- IPR001461: Aspartic peptidase A1 (family) [89-415]
- IPR033121: Peptidase family A1 domain (domain) [103-416]
- IPR033819: Saccharopepsin (domain) [95-416]
Interaction partners: - Carboxypeptidase
- Proteinase B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009056 (catabolic process), GO:0051701 (biological process involved in interaction with host), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0071214 (cellular response to abiotic stimulus), GO:0019538 (protein metabolic process), GO:0075136 (response to host), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0052200 (response to host defenses), GO:0009057 (macromolecule catabolic process), GO:0052200 (response to host defenses), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0030163 (protein catabolic process), GO:0044000 (movement in host), GO:0052572 (response to host immune response), GO:0052031 (modulation by symbiont of host defense response), GO:0052572 (response to host immune response), GO:0004175 (endopeptidase activity), GO:0071260 (cellular response to mechanical stimulus), GO:0071482 (cellular response to light stimulus), GO:0052553 (modulation by symbiont of host immune response), GO:0034644 (cellular response to UV)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)