Protein: Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) (O43187)
Organism: Homo sapiens (Human)
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Sequence: MACYIYQLPSWVLDDLCRNMDALSEWDWMEFASYVITDLTQLRKIKSMERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFPDSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRSDLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRGHRHGKPFVFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSFIYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLEIIHSNVKSSNVLLDQNLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAKEICQKYLEKGAGRLPEDCAEALATAACLCLRRRNTSLQEVCGSVAAVEERLRGRETLLPWSGLSEGTGSSSNTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGEGRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIELFGP
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [192-441]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [2-95]
- IPR042151: IRAK2, death domain (domain) [3-91]
- IPR000719: Protein kinase domain (domain) [210-503]
- IPR000488: Death domain (domain) [14-93]
Interaction partners: - Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4
- TNF receptor-associated factor 6
- Myeloid differentiation primary response protein MyD88
- Interleukin-1 receptor-associated kinase 3
- Interleukin-1 receptor type 1
- Toll/interleukin-1 receptor domain-containing adapter protein
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Toll-like receptor 4
- Tumor necrosis factor receptor superfamily member 16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044093 (positive regulation of molecular function), GO:0043207 (response to external biotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0044092 (negative regulation of molecular function), GO:0009617 (response to bacterium), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:1901700 (response to oxygen-containing compound), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0002237 (response to molecule of bacterial origin), GO:0031663 (lipopolysaccharide-mediated signaling pathway), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0010468 (regulation of gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0071222 (cellular response to lipopolysaccharide), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0071396 (cellular response to lipid), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)