wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Octaketide synthase 2 (OKS 2) (EC 2.3.1.-) (Polyketide synthase 4) (C4NF90)
Organism: Aloe arborescens (Kidachi aloe)
Function: Catalyzes the iterative condensations of 8 molecules of malonyl-CoA to produce aromatic octaketides, SEK4 and SEK4b, the products of the minimal polyketide synthase for the benzoisochromanequinone actinorhodin. May be involved in the biosynthesis of the octaketide barbaloin.
Sequence: MGSLSNYSPVMEDVQAIRKAQKADGTATVMAIGTAHPPHIFPQDTYADFYFRATNSEHKVELKKKFDRICKKTMIGKRYFNYDEEFLKKYPNITSFDEPSLNDRQDICVPGVPALGAEAAVKAIAEWGRPKSEITHLVFCTSCGVDMPSADFQCAKLLGLRTNVNKYCVYMQGCYAGGTVMRYAKDLAENNRGARVLVVCAELTIIGLRGPNESHLDNAIGNSLFGDGAAALIVGSDPIIGVERPMFEIVCAKQTVIPNSEDVIHLHMREAGLMFYMSKDSPETISNNVEACLVDVFKSVGMTPPEDWNSLFWIPHPGGRAILDQVEARLKLRPEKFGATRTVLWDCGNMVSACVLYILDEMRRKSVADGLATYGEGLEWGVLLGFGPGMTVETILLHSLPPV
InterPro domains: - IPR001099: Chalcone/stilbene synthase, N-terminal (domain) [16-238]
- IPR016039: Thiolase-like (homologous_superfamily) [3-402]
- IPR012328: Chalcone/stilbene synthase, C-terminal (domain) [248-401]
- IPR011141: Polyketide synthase, type III (family) [12-401]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016746 (acyltransferase activity), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: Probable inactive E3 ubiquitin-protein ligase SINAT6 (Protein SEVEN IN ABSENTIA 2) (Seven in absentia homolog 6) (Q93WE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable inactive E3 ubiquitin-protein ligase that plays a role in regulation of autophagy. Upon starvation, involved in maintaining ATG6 homeostasis by competitively associating with ATG6, a component of the autophagosome complex. Acts as positive regulator of drought stress response. Functions as positive regulator of abscisic acid-mediated stomatal closure.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24350984}. Nucleus {ECO:0000269|PubMed:24350984}.
Sequence: MEPRINDLQVESRVHELLDFPVHTNQISSAIYECPNDHIENPKKKPYNCPHSGAKCDVTGDIQRLLLHLRNDHNVEMSDGRSFSHRYVHHDPKHLHHATWMLTLLDCCGRKFCLYFEAFHLRKTPMYMAFMQFMGDEEEAMSFSYSLQVGGNGRKLTWQGVPRSIRDSHKTVRDSQDGLIITRKLALFFSTDNNTTDKELKLKVSGRVWREQPVSI
InterPro domains: - IPR052088: E3 ubiquitin-protein ligase SINA (family) [35-210]
- IPR008974: TRAF-like (homologous_superfamily) [74-205]
- IPR018121: Seven-in-absentia protein, TRAF-like domain (domain) [106-204]
Interaction partners: - TNF receptor-associated factor homolog 1a
- TNF receptor-associated factor homolog 1b
- Cyclin-dependent kinase G1
- Autophagy-related protein 13a
- 26S proteasome non-ATPase regulatory subunit 13 homolog B
- Cytochrome c-type biogenesis protein CcmE homolog, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0050794 (regulation of cellular process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0051128 (regulation of cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0036211 (protein modification process), GO:0033043 (regulation of organelle organization), GO:0043412 (macromolecule modification), GO:1902115 (regulation of organelle assembly), GO:2000785 (regulation of autophagosome assembly), GO:0070647 (protein modification by small protein conjugation or removal), GO:0044088 (regulation of vacuole organization), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Preprofallaxidin-1 [Cleaved into: Fallaxidin-4.1] (B5LUQ4)
Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)
Function: Fallaxidin-4.1 shows antibacterial activity against the Gram-positive bacteria L.lactis (MIC=12 uM), M.luteus (MIC=100 uM), S.epidermidis (MIC=100 uM) and S.uberis (MIC=50 uM). No antibacterial activity against the Gram-positive bacteria B.cereus, E.faecalis, L.innocua, S.aureus, or the Gram-negative bacteria E.cloacae and E.coli. Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 13.3 uM.
Subcellular location: Secreted {ECO:0000269|PubMed:18803332}.
Sequence: MASLKKSLFLVLFLGMVSLSICDKEKREGENEEEEEEHEEESEEKRGLLSFLPKVIGVIGHLIHPPS
InterPro domains: - IPR004275: Frog antimicrobial peptide, propeptide (domain) [3-46]
- IPR016322: Frog skin active peptide family (family) [1-66]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0032409 (regulation of transporter activity), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0051928 (positive regulation of calcium ion transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:2001259 (positive regulation of cation channel activity), GO:1901021 (positive regulation of calcium ion transmembrane transporter activity), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1904064 (positive regulation of cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:1904427 (positive regulation of calcium ion transmembrane transport), GO:0051924 (regulation of calcium ion transport), GO:2001257 (regulation of cation channel activity), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport), GO:1901385 (regulation of voltage-gated calcium channel activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: NAD(P)H-quinone oxidoreductase subunit H, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit H) (NADH-plastoquinone oxidoreductase 49 kDa subunit) (NADH-plastoquinone oxidoreductase subunit H) (Q6ENA1)
Organism: Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01358}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01358}; Stromal side {ECO:0000255|HAMAP-Rule:MF_01358}.
Sequence: MSLPLTRKDLMIVNMGPQHPSMHGVLRLIVTLDGEDVIDCEPILGYLHRGMEKIAENRTIIQYLPYVTRWDYLATMFTEAITVNAPEFLENIQIPQRASYIRVIMLELSRIASHLLWLGPFMADLGAQTPFFYIFRERELIYDLFEAATGMRMMHNYFRIGGVAADLPYGWIDKCLDFCDYFLRGVIEYQQLITQNPIFLERVEGVGFISGEEAVNWGLSGPMLRASGIQWDLRKVDLYESYNQFDWKVQWQKEGDSLARYLVRIGEMRESIKIIQQAVEKIPGGPYENLEVRRFKKAKNSEWNDFEYRFLGKKPSPNFELSKQELYARVEAPKGELGIYLVGDDSLFPWRWKIRPPGFINLQILPQLVKKMKLADIMTILGSIDIIMGEVDR
InterPro domains: - IPR029014: [NiFe]-hydrogenase, large subunit (homologous_superfamily) [10-393]
- IPR022885: NAD(P)H-quinone oxidoreductase subunit D/H (family) [7-393]
- IPR001135: NADH-quinone oxidoreductase, subunit D (domain) [124-393]
- IPR014029: NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site (conserved_site) [47-58]
Interaction partners: - NAD
- NAD
- Uncharacterized protein
- NAD
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4
- Uncharacterized protein
- NAD
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: CYP enzymes assisting alcohol dehydrogenase (CrCYPADH) (EC 1.1.1.-) (Alcohol dehydrogenase 2) (A0A0C5DM37)
Organism: Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Function: May be a positive catalyzer of strictosidine production by assisting secologanin biosynthesis, thus being involved in monoterpene indole alkaloids accumulation.
Sequence: MQIITCKAVVCWAAGEPPVVEEILVEPPRSGEVRIKILFASLCHTDVLACKGFPTPMFPRVLGHEGVGVVECVGEGVSELREGDVVIPTYLGECGECENCESGRTNLCRTYPLQAFTGLMPDGSSRMSSAKGGEMLYQFLSCSTWSEYTVIDANYAVKIDSRIPLPHASFLSCGFTTGFGATWKEAKLQEGSSTVAVLGLGAVGLGAVEGARVQGVTQIIGIDINDNKREKGEAFGMTHFINPKKDNNKSISELVKELTKGQGVDVCFECTGVPDLVNEALESTKIGTGNMIMLGAGTQKSMTINFVSLLGCRTFKYSVFGGVKVQSDLPLIIQKCLNKEIQKIEQLLTHQVQLEDINRAFELLKEPDCVKVLITL
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [163-338]
- IPR020843: Enoylreductase domain (domain) [15-374]
- IPR013149: Alcohol dehydrogenase-like, C-terminal (domain) [202-330]
- IPR011032: GroES-like superfamily (homologous_superfamily) [2-189]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [30-160]
- IPR002328: Alcohol dehydrogenase, zinc-type, conserved site (conserved_site) [63-77]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901700 (response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0009820 (alkaloid metabolic process), GO:0035834 (indole alkaloid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: B9 domain-containing protein 2 (MKS1-related protein 2) (Q9BPU9)
Organism: Homo sapiens (Human)
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19208769}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19208769}. Nucleus {ECO:0000250}.
Sequence: MAEVHVIGQIIGASGFSESSLFCKWGIHTGAAWKLLSGVREGQTQVDTPQIGDMAYWSHPIDLHFATKGLQGWPRLHFQVWSQDSFGRCQLAGYGFCHVPSSPGTHQLACPTWRPLGSWREQLARAFVGGGPQLLHGDTIYSGADRYRLHTAAGGTVHLEIGLLLRNFDRYGVEC
InterPro domains: - IPR010796: B9-type C2 domain (family) [2-175]
Interaction partners: - B9 domain-containing protein 1
- Coiled-coil and C2 domain-containing protein 2A
- Tectonic-1
- Transmembrane protein 231
- Meckelin
- Tectonic-2
- Transmembrane protein 216
- Tectonic-3
- Tectonic-like complex member MKS1
- Centrosomal protein of 290 kDa
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0036064 (ciliary basal body), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Lividin-3 (Q2UXR2)
Organism: Odorrana livida (Green mountain frog) (Polypedates lividus)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000255, ECO:0000269|PubMed:16713657}.
Sequence: MFTLKKSLLLLFFLGTISLSLCEEERDADEDEGEMTEEEVKRSVLGTVKDLLIGAGKSAAQSVLTALSCKLSNSC
InterPro domains: - IPR004275: Frog antimicrobial peptide, propeptide (domain) [2-41]
- IPR012521: Frog antimicrobial peptide, brevinin-2/esculentin type (domain) [45-75]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Vomeronasal 2, receptor 83 (A0A3B2WD89)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MLFSCLFFTWLLQMPTLIWTFATSSCLSESEYLLHHDGTVVIGAFFPILKSLPVSETIDWKTLSFDIDNVLEMNVHNYQLVLTMLFAINEINLNSHILPNTSLGLEIYNVPYLQRNALRNVFYWLTGLSTFIPNYSCRKNSKSAATLTGILWKTSENIGTVLDLYKFPQITFGPFDHDQIDRKQFPSLYQVAPKDTSLLSGIASLMLHFNWTWVGLLSTDDHRGAQFLSDLRKVLENNTVCIAFMETVSLWGESLNSLQTHYQMHILESSANVIVIYGSIAFILTVIKNRHSKYITKKVWVMNSKWVGQKFEQYTMLELSHGALSFSHHHGEIFGFTNFVHEATPFKYPEDIFLHVLWNKYFNCSLLQSDCKIIEKCLPNSSLELLPGNIFEMIMTEESYNVYNAVYAVAHSLHEMTLSQMQVQPQAYKDRTMLFPWQVFHY
InterPro domains: - IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [34-442]
- IPR000337: GPCR, family 3 (family) [37-214]
- IPR001828: Receptor, ligand binding region (domain) [83-424]
- IPR000068: GPCR, family 3, extracellular calcium-sensing receptor-related (family) [34-442]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0004984 (olfactory receptor activity), GO:0038022 (G protein-coupled olfactory receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: V-type ATP synthase beta chain (V-ATPase subunit B) (Q56404)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.
Sequence: MDLLKKEYTGITYISGPLLFVENAKDLAYGAIVDIKDGTGRVRGGQVIEVSEEYAVIQVFEETTGLDLATTSVSLVEDVARLGVSKEMLGRRFNGIGKPIDGLPPITPEKRLPITGLPLNPVARRKPEQFIQTGISTIDVMNTLVRGQKLPIFSGSGLPANEIAAQIARQATVRPDLSGEGEKEEPFAVVFAAMGITQRELSYFIQEFERTGALSRSVLFLNKADDPTIERILTPRMALTVAEYLAFEHDYHVLVILTDMTNYCEALREIGAAREEIPGRRGYPGYMYTDLATIYERAGVVEGKKGSVTQIPILSMPDDDRTHPIPDLTGYITEGQIQLSRELHRKGIYPPIDPLPSLSRLMNNGVGKGKTREDHKQVSDQLYSAYANGVDIRKLVAIIGEDALTENDRRYLQFADAFERFFINQGQQNRSIEESLQIAWALLSMLPQGELKRISKDHIGKYYGQKLEEIWGAPQALD
InterPro domains: - IPR055190: ATP synthase A/B type, C-terminal domain (domain) [365-463]
- IPR022879: V-type ATP synthase regulatory subunit B/beta (family) [1-472]
- IPR020003: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (active_site) [350-359]
- IPR004100: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain (domain) [11-68]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [82-364]
- IPR000194: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain (domain) [134-359]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Preprofallaxidin-2 [Cleaved into: Fallaxidin-3.1; Fallaxidin-3.2] (B5LUQ3)
Organism: Litoria fallax (Eastern dwarf tree frog) (Hylomantis fallax)
Function: Fallaxidin-3.1 shows antibacterial activity against the Gram-positive bacteria E.faecalis (MIC=100 uM) and L.lactis (MIC=100 uM). No antibacterial activity against the Gram-positive bacteria B.cereus, L.innocua, M.luteus, S.epidermidis, S.uberis and S.aureus, or the Gram-negative bacteria E.cloacae and E.coli.
Subcellular location: Secreted {ECO:0000269|PubMed:18803332}.
Sequence: MASLKKSLFLVLFLGLVSLSICEKEKRENEGNENEEEEENHEEGSEEKRGLLDLAKHVIGIASKLGKRSEEKRGLLDFAKHVIGIASKLGK
InterPro domains: - IPR004275: Frog antimicrobial peptide, propeptide (domain) [3-49]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)