Protein: C-C motif chemokine 3-like 1 (G0/G1 switch regulatory protein 19-2) (LD78-beta(1-70)) (PAT 464.2) (Small-inducible cytokine A3-like 1) (Tonsillar lymphocyte LD78 beta protein) [Cleaved into: LD78-beta(3-70); LD78-beta(5-70)] (P16619)
Organism: Homo sapiens (Human)
Function: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
Subcellular location: Secreted.
Sequence: MQVSTAALAVLLCTMALCNQVLSAPLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPSVIFLTKRGRQVCADPSEEWVQKYVSDLELSA
InterPro domains: - IPR039809: Chemokine beta/gamma/delta (family) [5-89]
- IPR000827: CC chemokine, conserved site (conserved_site) [34-75]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [26-90]
- IPR001811: Chemokine interleukin-8-like domain (domain) [31-89]
Interaction partners: - C-C chemokine receptor type 5
- C-C chemokine receptor type 1
- C-C chemokine receptor type 3
- C-C motif chemokine 3
- C-C motif chemokine ligand 4 like 2.
- C-C chemokine receptor type 2
- Tumor necrosis factor
- Atypical chemokine receptor 2
- C-C chemokine receptor type 7
- CX3C chemokine receptor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0016740 (transferase activity), GO:0030545 (signaling receptor regulator activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0042802 (identical protein binding), GO:0008047 (enzyme activator activity), GO:0030546 (signaling receptor activator activity), GO:0005102 (signaling receptor binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004674 (protein serine/threonine kinase activity), GO:0048018 (receptor ligand activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0010857 (calcium-dependent protein kinase activity), GO:0005126 (cytokine receptor binding), GO:0060229 (lipase activator activity), GO:0001664 (G protein-coupled receptor binding), GO:0016004 (phospholipase activator activity), GO:0009931 (calcium-dependent protein serine/threonine kinase activity), GO:0042056 (chemoattractant activity), GO:0005125 (cytokine activity), GO:0004697 (protein kinase C activity), GO:0042379 (chemokine receptor binding), GO:0008009 (chemokine activity), GO:0048020 (CCR chemokine receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0048870 (cell motility), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0042330 (taxis), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0002683 (negative regulation of immune system process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0001775 (cell activation), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0048878 (chemical homeostasis), GO:0050900 (leukocyte migration), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0001503 (ossification), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:2000145 (regulation of cell motility), GO:0043207 (response to external biotic stimulus), GO:0002685 (regulation of leukocyte migration), GO:0002366 (leukocyte activation involved in immune response), GO:0030154 (cell differentiation), GO:0051282 (regulation of sequestering of calcium ion), GO:0080134 (regulation of response to stress), GO:0098660 (inorganic ion transmembrane transport), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002694 (regulation of leukocyte activation), GO:1903706 (regulation of hemopoiesis), GO:0034220 (monoatomic ion transmembrane transport), GO:0030279 (negative regulation of ossification), GO:1903707 (negative regulation of hemopoiesis), GO:0055082 (intracellular chemical homeostasis), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0030595 (leukocyte chemotaxis), GO:0043270 (positive regulation of monoatomic ion transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0002443 (leukocyte mediated immunity), GO:0007166 (cell surface receptor signaling pathway), GO:0031349 (positive regulation of defense response), GO:0006935 (chemotaxis), GO:0050865 (regulation of cell activation), GO:0030278 (regulation of ossification), GO:0070168 (negative regulation of biomineral tissue development), GO:0016477 (cell migration), GO:0097529 (myeloid leukocyte migration), GO:0050801 (monoatomic ion homeostasis), GO:0009967 (positive regulation of signal transduction), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0050920 (regulation of chemotaxis), GO:0001649 (osteoblast differentiation), GO:0071674 (mononuclear cell migration), GO:0009636 (response to toxic substance), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0098771 (inorganic ion homeostasis), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:2000147 (positive regulation of cell motility), GO:0045087 (innate immune response), GO:0050867 (positive regulation of cell activation), GO:0043299 (leukocyte degranulation), GO:0002687 (positive regulation of leukocyte migration), GO:0098542 (defense response to other organism), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0002263 (cell activation involved in immune response), GO:0010647 (positive regulation of cell communication), GO:0002274 (myeloid leukocyte activation), GO:0050795 (regulation of behavior), GO:0050921 (positive regulation of chemotaxis), GO:0071621 (granulocyte chemotaxis), GO:0098655 (monoatomic cation transmembrane transport), GO:0031347 (regulation of defense response), GO:0097305 (response to alcohol), GO:0097530 (granulocyte migration), GO:0036314 (response to sterol), GO:0000165 (MAPK cascade), GO:0051209 (release of sequestered calcium ion into cytosol), GO:0002237 (response to molecule of bacterial origin), GO:0031663 (lipopolysaccharide-mediated signaling pathway), GO:0071702 (organic substance transport), GO:0030334 (regulation of cell migration), GO:0010468 (regulation of gene expression), GO:0019932 (second-messenger-mediated signaling), GO:0045637 (regulation of myeloid cell differentiation), GO:0006887 (exocytosis), GO:0045638 (negative regulation of myeloid cell differentiation), GO:0051928 (positive regulation of calcium ion transport), GO:0050729 (positive regulation of inflammatory response), GO:0031644 (regulation of nervous system process), GO:0002444 (myeloid leukocyte mediated immunity), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:1902105 (regulation of leukocyte differentiation), GO:1902533 (positive regulation of intracellular signal transduction), GO:0002688 (regulation of leukocyte chemotaxis), GO:0071675 (regulation of mononuclear cell migration), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0048247 (lymphocyte chemotaxis), GO:0043491 (protein kinase B signaling), GO:0034097 (response to cytokine), GO:0022604 (regulation of cell morphogenesis), GO:0030500 (regulation of bone mineralization), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:1902106 (negative regulation of leukocyte differentiation), GO:0043030 (regulation of macrophage activation), GO:1905523 (positive regulation of macrophage migration), GO:1905521 (regulation of macrophage migration), GO:0071310 (cellular response to organic substance), GO:0060284 (regulation of cell development), GO:0046903 (secretion), GO:0010628 (positive regulation of gene expression), GO:0036230 (granulocyte activation), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0006811 (monoatomic ion transport), GO:0055074 (calcium ion homeostasis), GO:0070167 (regulation of biomineral tissue development), GO:0060326 (cell chemotaxis), GO:0002548 (monocyte chemotaxis), GO:0098662 (inorganic cation transmembrane transport), GO:0006954 (inflammatory response), GO:0055080 (monoatomic cation homeostasis), GO:0050727 (regulation of inflammatory response), GO:0033993 (response to lipid), GO:0043032 (positive regulation of macrophage activation), GO:0016192 (vesicle-mediated transport), GO:0002275 (myeloid cell activation involved in immune response), GO:0072676 (lymphocyte migration), GO:0034341 (response to type II interferon), GO:0014070 (response to organic cyclic compound), GO:0043269 (regulation of monoatomic ion transport), GO:0006996 (organelle organization), GO:0010721 (negative regulation of cell development), GO:1902531 (regulation of intracellular signal transduction), GO:0071222 (cellular response to lipopolysaccharide), GO:0006812 (monoatomic cation transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)