Protein: Dedicator of cytokinesis 8 (F1QJ79)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MASLPASERRAFALKINRHSSAEIRRHFSGVSHGSLPHHRHSYNASGSFCFNVPQSYEAVEPVDLDEFLMSQLRSGDAEVMQELGEFPDDDLDVELVERECRTIRPTIAEEGVELDSHVRDCVQSYTQPWLVVSRRSQGYGWISYSDRTDSNKILQRQTFESDVQPDKQEQLDKSPSLTALCDDSARTTLTSSDFNLRALQPDQRVESVLRFSSPEELDRFNQESRQSNRYGELFGLYPPIDEEDAVAIRPIPDCPKEHFGQRILVRCQTVKFEIEIEPLFATMALYDLKEKKKISENFNFDLNSDQMKGFLRTHTPQVDTSTLSRSAIFSISYPSPDIYLVIKIEKVLQQGEIGDCAEPYMVLKESDTTKNRDKLEKLRNQAEGFCQRLGRYRMPLAFATVNIMSVINSTLERETSDTDSINGRGSMDKKGLPRRNSDRFSLMEDNYILSGFKPAVTMCTFIKQEGERLSDEDLFKFLADIKRSSSQRRVKIIPGYLKLEVLPAPDTVPGCLSPELIPVKPVSEKNQRPIKEVLEFPSKEVYVPHNIYRNLLYVYPLRLNLTNRLTSARNITVKIQFMSGEDSSCAMPVIFGKSSGPEFLTEVYTPVTYHNRSPDFYDEIKILLPARLTDKHHLLFTFFHISCQQKQNQTGSVEALIGYSWLPMLNNDRLQTSQQCLPIVLDKLPINYSLHTPEKLPAQVPPVKWLENHKGLFNLELQAVSSVQTQDSHLERFFTLCHALEGKSTFPIRVRDEKIQENMFEHELKLSIISLSSAGLEPLVLFLHQVLDKLFRLIMQPMVIAGQTANLAQIAFESVVSVINSLHNSQELAKDHQGRNCLLATYLYFVFRLPDTQYEIHTSGTGGLMAHPEGRYSTLTRTTATTVGFMLLQSRIRSSSNPDIPAPLSPEDTEVNNILGKVLNHPGSRMSTAANASNSPQSSTGSTRPTNKKLFHEELALQMVVSTGVCRENVYKYAWFFFEVLVKSMSQHVSQLDKKTVSRRNRFSDRFKDDITTIVNVVTAEIGNILVKQQKELEQAEKVNISLAFFLYDLMSLMDRGFVFQLVKNYCNQMAAKSVNMATLISMRLEFLRVLCSHEHYLNLSLFFSSPSSAPASPSPSVSSQTSSSCSFQDNKIAAMFDLSQDFKQRHYLTGLLLTELSTALDIESEGGRVQQKAINATYSLLCAHDLDQRCSRSEVKAKIAALYLPLVGIIIDSINYLDFTVSDSRSGKGKSGGPEEDPDNIATINQSVAMAIAGNPFNTLTRNALVSMASVSVKTTNMLTAETSRNLLMCFLWIIKNADQNLIQRWTVDMPSSQLSRLLELLAICTSCFEYRGKQSSDKVSTQALQKSQQAKARLEEALLGGIGARGEMMKRVGVQGNDRTLGLRENLRWRKDLTQWRQTNDRQDKSKAELDQEAIISGNLATETNLIVLDLLEMIVQAVPLADCKDNVVGGVLKVLLHSLTCNQSTTYLSHCFSTLRALIVKFGDLLFEEEAEQCADLCQKVLHYCSSCVDGNRSQACATLYLIMRYSYSSASNFSRVKMQVTMSLASLVGKSSDIHEEYLRRSFRTILAYAEEDTEMQSTQLPSQVDELLRNLNSILSDTVKMKEFQKDPEMLMDLMYRIAKGYQTSPDLRLTWLQNMAEKHNGRKCFTESAMCLVHAAALVAEYLSMLEDHKYLPVGSVTFQNISPNVLEESAVSDDILSPDEDGVCSGRYFTENGLVGLLEQAAELFSNGGLFEAVNEVYKVIVPILEAHRDFRKLASTHDKLQRAFDNIIQKGHKRMFGTYFRVGFYGSKFGDLDEQEFIYKEPGITHLPEISHRLENFYSQCFGDGVLEMIKDSTPVDRNKLSPNKAYIQITFVEPYFDDYEMKDRLTNFEKNFNLRRFMYTTPFTKSGRPRGELNEQYKRKTILTTMHAFPYIKTRINVIQKEEFDLTPIEVAIEDMQKKTRELAEATHREKPDAVMLQMVLQGSVTATVNQGPLEVAQVFLNEIPADPKLFRHHNKLRLCFKEFILRCGEAIEKNKQLITPDQKEYQQEMKKNYNKLRENLRPMLERKIPELYKPIIKPRIENRDSFKRHSLRRTQDEHS
InterPro domains: - IPR021816: Dedicator of cytokinesis C/D, N-terminal (domain) [58-163]
- IPR027007: C2 DOCK-type domain (domain) [547-730]
- IPR043161: Dedicator of cytokinesis, C-terminal, lobe A (homologous_superfamily) [1626-1782]
- IPR016024: Armadillo-type fold (homologous_superfamily) [1260-1613]
- IPR027357: DOCKER domain (domain) [1626-2060]
- IPR046769: DOCKER, Lobe A (domain) [1619-1778]
- IPR046770: DOCKER, Lobe B (domain) [1842-1917]
- IPR046773: DOCKER, Lobe C (domain) [1952-2053]
- IPR026791: Dedicator of cytokinesis (family) [49-2056]
- IPR035892: C2 domain superfamily (homologous_superfamily) [550-731]
- IPR037808: Dedicator of cytokinesis C, C2 domain (domain) [549-731]
- IPR043162: Dedicator of cytokinesis, C-terminal, lobe C (homologous_superfamily) [1938-2060]
Interaction partners: - Cell division cycle 42-like 2
- Cell division control protein 42 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0040017 (positive regulation of locomotion), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0045321 (leukocyte activation), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0002696 (positive regulation of leukocyte activation), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0002685 (regulation of leukocyte migration), GO:0071674 (mononuclear cell migration), GO:0032878 (regulation of establishment or maintenance of cell polarity), GO:0030155 (regulation of cell adhesion), GO:0009988 (cell-cell recognition), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0050865 (regulation of cell activation), GO:2000147 (positive regulation of cell motility), GO:0046649 (lymphocyte activation), GO:0050867 (positive regulation of cell activation), GO:0002687 (positive regulation of leukocyte migration), GO:0051251 (positive regulation of lymphocyte activation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0036336 (dendritic cell migration), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0022407 (regulation of cell-cell adhesion), GO:0071677 (positive regulation of mononuclear cell migration), GO:0030335 (positive regulation of cell migration), GO:0071675 (regulation of mononuclear cell migration), GO:0030334 (regulation of cell migration), GO:2000114 (regulation of establishment of cell polarity), GO:0051249 (regulation of lymphocyte activation), GO:0042981 (regulation of apoptotic process), GO:0050870 (positive regulation of T cell activation), GO:0050863 (regulation of T cell activation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:2000401 (regulation of lymphocyte migration), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0043066 (negative regulation of apoptotic process), GO:2000403 (positive regulation of lymphocyte migration), GO:2000107 (negative regulation of leukocyte apoptotic process), GO:2000106 (regulation of leukocyte apoptotic process), GO:2000404 (regulation of T cell migration), GO:2000406 (positive regulation of T cell migration), GO:0070228 (regulation of lymphocyte apoptotic process), GO:0070229 (negative regulation of lymphocyte apoptotic process), GO:0070232 (regulation of T cell apoptotic process), GO:0070233 (negative regulation of T cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)