Protein: Condensin-2 complex subunit CAP-D3 (Protein CHROMOSOME-ASSOCIATED POLYPEPTIDE D-3) (AtCap-D3) (O24610)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids (By similarity). Required for plant vigor, fertility, chromatin condensation and sister chromatid cohesion both during mitosis and meiosis. Necessary to maintain normal structural integrity of the meiotic chromosomes during the two nuclear divisions of gametogenesis, especially to prevent interchromosome connections at metaphase I. Seems also involved in crossover formation during meiotic prophase I. Prevents centromeric and pericentromeric heterochromatin repeats association.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768, ECO:0000269|PubMed:23929493, ECO:0000269|PubMed:27385818}. Chromosome {ECO:0000269|PubMed:23929493, ECO:0000269|PubMed:25065716, ECO:0000269|PubMed:27385818}. Note=Observed throughout euchromatic nucleoplasm (PubMed:23929493, PubMed:27385818). Associates with the chromosomes throughout meiosis (PubMed:25065716). {ECO:0000269|PubMed:23929493, ECO:0000269|PubMed:25065716, ECO:0000269|PubMed:27385818}.
Sequence: MDEELLLTRILAGIEGGDDESDYHELVTDLKSLLDTDDDEILNRFYGSLSSMASSFLRCISAAMDSPVESGRLAILASDAYLSLLLSTNCPVFTFFSPIAFLSLLGSIRRYLKRRDDSAGQGSNSQREKGNKKKRGRGKRNLGYEDGEETEEGGFDAKLMFIVLEKLGSVLSFVHLDRFPDSLKSLVQTVSEIPLLALEHSGVLNYDRLMEMCGKILGGVLNSDHGDMALTAAEISKSLTPLLLMGKHQARSFALGFVSRKLMSLAKDNPELKKVVSNLPKFLVHKAPEKAEPRGFAVEAVLEIVKAMEVEGQSEFVDFVMKMCQGKSNFRVLAVDIIPLLISSLGNPLGDISSENGLKDSWGLGCIDALVQRCSDTSALIRARALSNLAQVVEFLSGDERSRSILKQALGFNGETSEGKGAVTDLLKKRCVDEKAAVRRAALLLVTKLTSLMGGCFDGSILKTMGTSCSDPLISIRKAAVSAISEAFRICTDEIVTTEWLHSVPRMIMDNETSIQEECENVFHELVLERILRAGNVLSPDSASLPNNRNTTSKDLDRDIEALFPEGVLVLLRELCNSEVSPWVTKICGSLGKKKRLKPRVALALQCIIKESESLWLSRSMPINRWTAPAGAWFLLSEVSVYLSKSVEWEFLHHHWQLLDKNDVQGLDEQGDEQGVECNSSTWAGDRVCLLQTISNVSLQLPAEPAADLADNLLKKIENFNLHSAEVDAHVKALKTLCKKKASTSEEADMLVKKWVEQVSLKASKVTEKYIEGVSSHNHSFVTPATLGSRRSKRLDTVSKKLSKAVTAVYTIGSCVIIYPSADTTKIVPFLHTVITSGNSDSKLKNKLPQANVCLKQKAPLLYSQSWLTMAKMCLADGKLAKRYLPLFAQELEKSDCAALRNNLVVAMTDFCVHYTAMIECYIPKITKRLRDPCEVVRRQTFILLSRLLQRDYVKWRGVLFLRFLLSLVDESEKIRRLADFLFGSILKVKAPLLAYNSFVEAIYVLNDCHAHTGHSNPDSKQSRTKDQVFSIRGNDERARSKRMQIYVTLLKQMAPEHLLATFAKLCAEILAAASDGMLNIEDVTGQSVLQDAFQILACKEIRLSVSRGASSETADIEEEGGDAATAKGRAITHAVRKGLIQNTIPIFIELKRLLESKNSPLTGSLMDCLRVLLKDYKNEIEEMLVADKQLQKELVYDMQKHEAAKARSMANQGVACGTSHRNGEPEASAASEENVRDSGLESRVVSAAADVVAAKAARSVLREVNGGAATPPLSAMSVPKLRSSRGVSQSGRPSADVLESLRRRPTFMSDDES
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [269-1177]
- IPR026971: Condensin subunit 1/Condensin-2 complex subunit D3 (family) [40-1290]
- IPR012371: Condensin-2 complex subunit D3 (family) [1-1314]
- IPR011989: Armadillo-like helical (homologous_superfamily) [233-531]
- IPR032682: Condensin complex subunit 1, C-terminal (domain) [900-1058]
Interaction partners: - Condensin-2 complex subunit H2
- ARM repeat superfamily protein
- Structural maintenance of chromosomes protein 2-1
- Structural maintenance of chromosomes protein 2-2
- Structural maintenance of chromosomes protein 4
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein 3
- Retinoblastoma-related protein 1
- Structural maintenance of chromosomes protein 5
- Structural maintenance of chromosomes protein 6A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009561 (megagametogenesis), GO:0016043 (cellular component organization), GO:0009559 (embryo sac central cell differentiation), GO:0048229 (gametophyte development), GO:0010197 (polar nucleus fusion), GO:0006996 (organelle organization), GO:0009553 (embryo sac development), GO:0048284 (organelle fusion), GO:0006997 (nucleus organization), GO:0000741 (karyogamy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)