Protein: Inducible T-cell co-stimulator ligand (cDNA FLJ77643, highly similar to Homo sapiens B7-like protein (B7H2), mRNA) (cDNA, FLJ95137, Homo sapiens B7-like protein (B7H2), mRNA) (A0N0L8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTGHV
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [20-129]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [20-228]
- IPR007110: Immunoglobulin-like domain (domain) [6-227]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [17-236]
- IPR003599: Immunoglobulin domain subtype (domain) [22-135]
- IPR050504: Immunoglobulin superfamily BTN/MOG domain-containing protein (family) [10-258]
- IPR053896: Butyrophilin subfamily 3 member A2-like, Ig-C domain (domain) [148-225]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048522 (positive regulation of cellular process), GO:0002696 (positive regulation of leukocyte activation), GO:0042127 (regulation of cell population proliferation), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0050865 (regulation of cell activation), GO:0050867 (positive regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0051251 (positive regulation of lymphocyte activation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0070665 (positive regulation of leukocyte proliferation), GO:0070663 (regulation of leukocyte proliferation), GO:0051249 (regulation of lymphocyte activation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050670 (regulation of lymphocyte proliferation), GO:0050870 (positive regulation of T cell activation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0042102 (positive regulation of T cell proliferation), GO:0042129 (regulation of T cell proliferation), GO:0042104 (positive regulation of activated T cell proliferation), GO:0046006 (regulation of activated T cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:1903561 (extracellular vesicle)