Protein: Alpha-2-HS-glycoprotein (Fetuin-A) (C9JV77)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVAIDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSVRQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPADSAEDVRKVCQDCPLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAKCNLLAEKQYGFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPDAPPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVSHPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV
InterPro domains: - IPR001363: Proteinase inhibitor I25C, fetuin, conserved site (conserved_site) [83-92]
- IPR025760: Fetuin-A-type cystatin domain (domain) [27-256]
- IPR050735: Kininogen/Fetuin/Histidine-rich Glycoprotein (family) [1-319]
- IPR046350: Cystatin superfamily (homologous_superfamily) [30-247]
- IPR000010: Cystatin domain (domain) [21-249]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0050920 (regulation of chemotaxis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0002686 (negative regulation of leukocyte migration), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0032101 (regulation of response to external stimulus), GO:0090288 (negative regulation of cellular response to growth factor stimulus), GO:0045785 (positive regulation of cell adhesion), GO:1903706 (regulation of hemopoiesis), GO:0050867 (positive regulation of cell activation), GO:0002687 (positive regulation of leukocyte migration), GO:1903707 (negative regulation of hemopoiesis), GO:0035295 (tube development), GO:2000026 (regulation of multicellular organismal development), GO:0050922 (negative regulation of chemotaxis), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0045596 (negative regulation of cell differentiation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0051128 (regulation of cellular component organization), GO:2000146 (negative regulation of cell motility), GO:0032102 (negative regulation of response to external stimulus), GO:0021510 (spinal cord development), GO:0043254 (regulation of protein-containing complex assembly), GO:0031344 (regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:1901342 (regulation of vasculature development), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:1901214 (regulation of neuron death), GO:0030334 (regulation of cell migration), GO:0030336 (negative regulation of cell migration), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0045638 (negative regulation of myeloid cell differentiation), GO:0031346 (positive regulation of cell projection organization), GO:1902105 (regulation of leukocyte differentiation), GO:0007417 (central nervous system development), GO:0045765 (regulation of angiogenesis), GO:0002688 (regulation of leukocyte chemotaxis), GO:0071675 (regulation of mononuclear cell migration), GO:0010721 (negative regulation of cell development), GO:0030182 (neuron differentiation), GO:0002762 (negative regulation of myeloid leukocyte differentiation), GO:0050870 (positive regulation of T cell activation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0071622 (regulation of granulocyte chemotaxis), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway), GO:0042063 (gliogenesis), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0045671 (negative regulation of osteoclast differentiation), GO:2000404 (regulation of T cell migration), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)