Protein: Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Q3UMM4)
Organism: Mus musculus (Mouse)
Function: Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q15131}.
Sequence: MAEVDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIMLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATSGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPAAAEGQSKRCRP
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [33-330]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [159-171]
- IPR050108: Cyclin-dependent kinase (family) [36-329]
- IPR017441: Protein kinase, ATP binding site (binding_site) [45-68]
- IPR044093: Cyclin-dependent kinase 10, catalytic domain (domain) [31-339]
- IPR000719: Protein kinase domain (domain) [39-323]
Interaction partners: - Protein C-ets-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death), GO:0007399 (nervous system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043523 (regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:1990234 (transferase complex), GO:0043227 (membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex), GO:0000307 (cyclin-dependent protein kinase holoenzyme complex)