Protein: Mitochondrial inner membrane protein Mpv17 (Q9V492)
Organism: Drosophila melanogaster (Fruit fly)
Function: Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Can translocate uridine, but not orotate, across a lipid membrane. Involved in maintenance of mitochondrial ultrastructure. May be involved in mitochondrial DNA (mtDNA) maintenance but does not appear to be directly involved in mitochondrial deoxynucleoside triphosphate (dNTP) pool homeostasis. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MKRLKAYLKDGINVAAVMCLGDTISQFFFDKKSLDEWDAGRTLRFGIVGLVFVGPTLRRWYHFLESRVPKTYSPMRRGVTKMLVDQTLFAPPFTMAMSFLVPLSNGEPIDRIRQRILDSYLSILVRNYMLWPAAQMLNFRFVPLGYQVLYAQFIALVWNCYLSMILNS
InterPro domains: - IPR007248: Mpv17/PMP22 (family) [15-164]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0009791 (post-embryonic development), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0003002 (regionalization), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0048513 (animal organ development), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0035107 (appendage morphogenesis), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0090066 (regulation of anatomical structure size), GO:0032535 (regulation of cellular component size), GO:0007447 (imaginal disc pattern formation), GO:0007224 (smoothened signaling pathway), GO:0048737 (imaginal disc-derived appendage development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0007444 (imaginal disc development), GO:0006996 (organelle organization), GO:0008610 (lipid biosynthetic process), GO:0008587 (imaginal disc-derived wing margin morphogenesis), GO:0035220 (wing disc development), GO:0007010 (cytoskeleton organization), GO:0016070 (RNA metabolic process), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0007472 (wing disc morphogenesis), GO:0008361 (regulation of cell size)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)