Protein: T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (P28480)
Organism: Rattus norvegicus (Rat)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P17987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P17987}.
Sequence: MEGPLSVFGDRSTGEAIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIINTDELGRDCLINAAKTSMSSKIIGINGDFFANMVVDAVLAVKYTDIRGQPRYPVNSVNILKAHGRSQIESMLINGYALNCVVGSQGMLKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGASILSTLANLEGEETFEATMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGGYENAVHSGALDD
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [138-406]
- IPR053374: TCP-1 chaperonin-containing T-complex (family) [11-531]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [207-379]
- IPR054827: Thermosome subunit alpha (family) [10-532]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [28-533]
- IPR002194: Chaperonin TCP-1, conserved site (conserved_site) [33-90]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [10-533]
- IPR017998: Chaperone tailless complex polypeptide 1 (TCP-1) (family) [12-533]
- IPR012715: T-complex protein 1, alpha subunit (family) [6-539]
Interaction partners: - T-complex protein 1 subunit gamma
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit zeta
- Chaperonin containing TCP1 subunit 6B)
- Chaperonin containing TCP1 subunit 8 like 2
- Endoplasmic reticulum membrane-associated RNA degradation protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000242 (pericentriolar material), GO:0000785 (chromatin), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0140535 (intracellular protein-containing complex), GO:0043209 (myelin sheath), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0101031 (chaperone complex), GO:0000792 (heterochromatin), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0005794 (Golgi apparatus), GO:0005832 (chaperonin-containing T-complex), GO:0043227 (membrane-bounded organelle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005856 (cytoskeleton), GO:0005694 (chromosome), GO:0015630 (microtubule cytoskeleton)