Protein: Down syndrome cell adhesion molecule (A0A139WBI8)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Membrane; Single- pass membrane protein
Sequence: MDESVLKGNTAIFKCHIPSFVSDYVSVVSWLQDDNNEIVNKDDRYDSKYLVLPSGELHIRDVGPEDGYKSYQCRTKHRLTGETRLSATKGRLVITEPVGTKAPAFSTDIKVLGYQRHSKQNVALLCPAQGFPSPSFRWYKFVEGTTRKQAVTLNDRVKQVAGTLIIREAKVEDSGKYLCVVNNSVGGESVETVLTVTAPLKAKIEPQVQTIDFGRPATFTCNFEGNPIKTISWLKDGHPIDHNEAVLRIESVRKEDKGMYQCFIRNDQESAEATAELKLGGRFEPPQIRHAFNEETVQPGNSVFLKCIASGNPTPEITWELYGRRLSNSERNQIGQYVTVNGDVVSHLNITAIHTNDGGLYRCVASSKVGSADHSARINVYGLPFVRSMEKQAIVAGGTLIVHCPFAGHPVDSVVWERDGRQLPINRKQKVFINGTLIIENVERASDQATYDCVAKNSQGYSARGSLEVQVMVPPQILPFDFGEDSINEGDGVSVQCTVSKGDYPLNISWTLNGHFIDQTNGIVINRASKRVSTLSIDNVQSTHVGNYTCLASNSASVTTYTTSLFINVPPRWILEPTDKAFAQGSDAAVECKADGFPRPVVTWKRATGVSPGDYKDFKPNNPDIKVEDGTLTINNIQKTNEGYYLCEAVNGIGSGLSAVIQISVQAPPQFDIKLRNQTSRRGDPAVLQCEAKGEKPIGILWNINNKRLEPKGDNRYTIREEILANGVLSGLSIKRTERSDSALFTCVATNAFGSDDTSINMIVQEVPEVPYGLKVLDKSGRSVQLSWVAPFDGNSPITRYMIEYKQSKVSWEGNTERVLVPGDQTEAGVFTLRPATTYHIRIVAENEIGSSEPSETVTIITAEEVPGGPPTSIRVETNDQHSLVVYWKPPAREEWNGDILGYYVGYRLANSDKPYLFETVEFGREEGKEHHLKISNLKTYTQYSVVVQAFNKVGAGPLSDDIKAYTAEGVPEQPPDKATCTTLTAQTIRVSWVSPPLTAANGVIKGYKVIYGPSDTWFDENTKDTKITAASETILHGLKKYTNYSMEVLAYTSGGDGVRTTPIHCQTEQDVPEAPIAVKALVMSTDSILASWKPPVEPNGIVEYYTVYYKPVSTDDKTEVKPTSQKIVPNLRNQNLSHQAKNLDSNLKYEFWVTAATTIGEGQPSKKVTVSPSASVPAKIASFDDTFTTTYKEDVTLPCLAVGLPPPVITWKIKGVQFTTSDKIRQQPDGSLFIRDVSRNNAGEYSCHVENDYGQDSVTHQLIVNAPPHAPQIALTSTTTNSLTFKLKPHESDVEPIHGYTIHYKPEFGDWETVQIGPTVEKYTLEKLLCGTRYQVYAKAYNSIGTGDPSDTLNPRTRGEKPIVPSAEKFIEVSSNSITLHLSAWSDGGCPMLYFVIEHKKKTSTEWIQVSNNVKLGQNFVLLDLDPACWYHLRVTAHNNAGFNVAEYEFATLTVTGGTIAPAREIPKEDTFQIILANLNLVVPVVAAVLVIIVAIIVICVLRGKGNYHKDDVVYNQSVNASSTLDKRRPDLRDELGYIAPPNRKLPPVPGSNYNTCDRIKRGTVLRAHYRSHSTWDPRRHLYEELRSRRGSNETVHTHRGMDDEICPYATFHLLGFREEMDPSKAMQFQTFPHPHSGTMGPSGMNTPHQIHSRSGSQSMPRQNRRYDRVGSQGNGSIYSPGPEYDDPANCAPEDEQYGSQYGGYGAPYDQYGSRGSIGRRSLGSLRLQPTSSSPEPPPPPPRNHDPSFNDSKDSNEISEAECDRDQLINSRTYGVMRGSSKDGMSHEEMRKLIERNETGQANGGLTAYDTVAV
InterPro domains: - IPR013098: Immunoglobulin I-set (domain) [118-1265]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [3-1272]
- IPR021012: Cell adhesion molecule Dscam1, C-terminal (domain) [1680-1793]
- IPR007110: Immunoglobulin-like domain (domain) [1-1266]
- IPR003598: Immunoglobulin subtype 2 (domain) [117-1255]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [766-1446]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-1456]
- IPR003961: Fibronectin type III (domain) [768-1460]
- IPR056754: DSCAM/DSCAML, C-terminal domain (domain) [1375-1463]
- IPR003599: Immunoglobulin domain subtype (domain) [3-1266]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)