Protein: BRCA2 (Q8R4X4)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Not known
Sequence: KNCSHIQPWETDCLSCLPERQCEYDPKGPKVSDGKEEVLVSACHPAGQHTAAAQPSSISFELQEDPVNGHNSTSPKETPSLKVLLSKPVVLSRGKVSCKMPEKLQCESYKDNTELSKSIPLGGNKIHILSENSKPPELLPPGKYVTEASPTVKSQFNQNTNLAVKKNDQEETPFISEVTVNVSSGELFPDNENNFAFQVTHENNKTALGSTVELQEEDLRHAKGPNLNNSPTAVDGDIGDEQAAHALIMEDSDSSALVHECAKKSRNTIEQHLKGTTDKDFNSSLDVKSDGNNDYTDKWPGFLDPVFKHKFGGSFRTASNKEIKLSEHNVKKSKMFFKDIEEEYPTSLTCIDIVNASPLANQEILSGPYTFDLQSVTTMSAHPQSQASVSCEDTHTSLQVLPSKQDFHSNHNLTPSQKAEITELSTILEESGSQFEFTQFKKPSHVAQNNIPEVPGKQTVAINTTSEGWKRIGLHLTVDPASVAQTDDSKKFEGSAGFRQSFPCLLKSSCNKNTSSFLANVNEMEFRGFRSALGTKLSVSSEALQKAVKLFSDIESGSEETSTKVDPRALSSGARHDSGASVFKIRKQNSGKSFDEKTSKCQVTLQNNTEVTTGIFVDRNPENYARNTKCEDNNSTGFQRSPYKLKNSEDSESSTSGTVSVHQDDGDLPCAADHCSKYPESCSQYVREENTQIKECVSDLTCLEVMKAEETCYIQPSDKEQLPSGKMEQNRKDFNISFQTASGKNVRVSEESLSKSMNILNQVTDESIISSDSLNSKFHCGTNNNKMGISHHKETTSTKKVFEERFPVGTVSQLPTLQQHPRCEIESIKEPALLGFHTASGKKVKIMQKSLDKVKNLFDETQYVSHQGSKPLKDRENCKEGLALGCETIEIPASKCEEMQKSFLSKESEVLSKQSDRLYRSTENLRTSNGTSSKANVHGNIESEIEKSPTTCCISHLSYSVTEDSALTCDTGHGRKTCVSESSLSKDRKWLRDRLGDKLQKRDAAEIECVKEHTEGYAGDASCEHSLDSIRNEVDINCVSENQTSALFSDPSMCHSCPSHFGCHCDNKHNDSGYFSKNKIYSDTQPDTKNEDTANFSSVYATKEVNIYPPTVNEDICVQKLETNSSPHTNKNVAIDLAIADSRNCKVCPSKFITDHSQETVKTVKAIFTHNSDKTIKQNTKSKPDTCRTSCQKALDNSEDFICPSSLEDDYMNSHKTSVYTHDEQILQHNLSVSGLEKAQIPPVHLETWDKCKSTRELAQAACSSHMPGIFSTASGKAVQVSDASLEKARQVFSEMDGGAKQLLSTLSLESHEQSDHSGRRENSVTHNPEDVLSLPKTFASNANSSVFSGFSTAGGKRVTVSESALHKVKGMLEEFDLIGTEHTLQCPPTSEGVSKILPQYCVEKRTPEYPINSKLQKTYDDKFSLPNNYKESASLGNTHSLEASPQLSQFKQDTRLVLGTKVSLLEKEQTFPQNIKTESGVMET
InterPro domains: - IPR002093: BRCA2 repeat (repeat) [308-1378]
- IPR015525: Breast cancer type 2 susceptibility protein (family) [2-1485]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009314 (response to radiation), GO:0046483 (heterocycle metabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0001817 (regulation of cytokine production), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045184 (establishment of protein localization), GO:0104004 (cellular response to environmental stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0071478 (cellular response to radiation), GO:0009416 (response to light stimulus), GO:0006974 (cellular response to DNA damage stimulus), GO:0051246 (regulation of protein metabolic process), GO:0072594 (establishment of protein localization to organelle), GO:0072331 (signal transduction by p53 class mediator), GO:1902532 (negative regulation of intracellular signal transduction), GO:2001020 (regulation of response to DNA damage stimulus), GO:0090304 (nucleic acid metabolic process), GO:0043620 (regulation of DNA-templated transcription in response to stress), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0006259 (DNA metabolic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0010212 (response to ionizing radiation), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0033365 (protein localization to organelle), GO:0051058 (negative regulation of small GTPase mediated signal transduction), GO:0033365 (protein localization to organelle), GO:0070199 (establishment of protein localization to chromosome), GO:0031399 (regulation of protein modification process), GO:0071479 (cellular response to ionizing radiation), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0019220 (regulation of phosphate metabolic process), GO:0006260 (DNA replication), GO:0009411 (response to UV), GO:1902692 (regulation of neuroblast proliferation), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0045936 (negative regulation of phosphate metabolic process), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0046578 (regulation of Ras protein signal transduction), GO:0042327 (positive regulation of phosphorylation), GO:0034644 (cellular response to UV), GO:0006302 (double-strand break repair), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0000725 (recombinational repair), GO:0034644 (cellular response to UV), GO:0000724 (double-strand break repair via homologous recombination), GO:0140527 (reciprocal homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)