Protein: Complement C3a, tandem duplicate 3 (F1QX13)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MEVKLLFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFVEAQDYSGGPLNVRISVKNFPAKNVEMMQKTVTLTGAKYQSLTDIQIPGDRNYFSDDEKKQYVYLQAHFPSVTLEKVVMVSFQSGYLFVQTDKPIYTPGSNVHYRIFSMTPNLKPFSKPGITVDITNPQGITVASDTIFAEKGVKSSIYNIPEVTSLGMWKVVTRYANTPQKTFTAEFEVKEYVLPTFEVKLKTSKSFYYVGDSKPKNNEDDSLTVDMEAKYLFGKKMDGNAFVVFGVMDGAMKTSIVNSLQKVQVFNGVGTAELTREMITKTFKNIKDLVGKSIYVSVNLLTESGSEMVEAEKRGIQIVTSPYTIHYKRTSQFFKPGMPLGVSVYVTNPDETPAEDVEVEVLVDGVGGVNSKTKANGIAKVTVNTKAGVSTLKITATTRDPELANEQQADKTMIAQAYKTNLGSKNYLHINIESAEFEIGDQMTVYLNTGESPGVKDQDFTYMILSKGQIVLAERFKRQGQTLVSLSLPVTKDMVPSFRFVAYYHVGKDEVVSDSVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGARVGLVVVDKAVQVLNKNRLTQSKIWDVIEKHDTGCTGGGGKDSMGVFSDAGLMFESDPAGGTNTRTEPKCPAPPKRKRRSESLQTITTTLAGQYTEKIRPCCYDGMRNNRIGYTCERRASYVIDGEECVKAFLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQFPESWLWEEFDLCDKCSKPSKNKVTYLKDSITTWQILAISLSPTHGICVAEPEEIVVFKSFFIDLKVPYSAVRGEQVEIKAIIHNYTPKHLKKVRVEFLETAGVCSAASKKGKYRATVNVDKDSSIAVSFVIVPMTLESQHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQPLLLRAGIPGDQVPGTPVHSYITVTGEEISQSIEHAINGSFMGELIKRPGGCGEQNMAKMTLPVVATHYLDNTNQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAIWINTPSSTWLTAYVAKVFAMANDFFAIEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNTDVSLTAFVLIAMQEGKEICGGTVGSLHESMRKAVAFLKDQLPKLTNPYAVALTSYALANADSLNKAILMMHSTKVNDERFWNVPERQYYSIEATAYAVLALVKAKDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVFQAVAEYHAQTQDLNNFDLNVELVVPGRRKTDRWTIQRSNVHLARSGNVDLNKDFTVIAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKLDKIPETKPGTNGTYNFILDFFYKNKKNDATMTILDIGLPTGFDIDEADLKQLSTGKERYIQKYEKNKVLSERGSLIIYLNKVSHEVSEKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPEREDSALYRLCKGDLCVCAEENCSYQKKNHVDESKRLIKACEPHLDYIYKAKLVKMDLKQDSDIYHMKVEKTVKEGTDTDVEGKVKQFLARPSCRVSLGLVEGKSYLIMGNSVDLPTLGGSLQYVIGEQTWIEYWPTSDESKSAEHRDRYIGMTAVENMFTTGGCLT
InterPro domains: - IPR002890: Macroglobulin domain (domain) [129-222]
- IPR001134: Netrin domain (domain) [1507-1649]
- IPR001599: Alpha-2-macroglobulin (domain) [768-862]
- IPR041555: Macroglobulin domain MG3 (domain) [224-315]
- IPR018933: Netrin module, non-TIMP type (domain) [1521-1633]
- IPR008993: Tissue inhibitor of metalloproteinases-like, OB-fold (homologous_superfamily) [1502-1650]
- IPR011625: Alpha-2-macroglobulin, bait region domain (domain) [461-602]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [355-1464]
- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [987-1275]
- IPR041425: Complement C3/4/5, macroglobulin domain MG1 (domain) [23-123]
- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1347-1502]
- IPR047565: Alpha-macroglobulin-like, thiol-ester bond-forming region (conserved_site) [990-1019]
- IPR018081: Anaphylatoxin, complement system (homologous_superfamily) [671-739]
- IPR019742: Alpha-2-macroglobulin, conserved site (conserved_site) [998-1006]
- IPR000020: Anaphylatoxin/fibulin (domain) [674-737]
- IPR011626: Alpha-macroglobulin-like, TED domain (domain) [972-1272]
- IPR048848: Complement component 3, CUB domain, second segment (domain) [1282-1341]
- IPR040839: Macroglobulin domain MG4 (domain) [358-451]
- IPR035815: Complement C3-like, NTR domain (domain) [1502-1649]
- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1386-1483]
Interaction partners: - Si:ch73-237c6.1
- Complement factor properdin
- Complement C5
- C3/C5 convertase
- Complement component C9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0043627 (response to estrogen), GO:0071310 (cellular response to organic substance), GO:0032870 (cellular response to hormone stimulus), GO:0071391 (cellular response to estrogen stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)