Protein: Low-density lipoprotein receptor (LDL receptor) (P35951)
Organism: Mus musculus (Mouse)
Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P01130}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01131}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:11247302}. Golgi apparatus {ECO:0000250|UniProtKB:P01130}. Early endosome {ECO:0000250|UniProtKB:P01130}. Late endosome {ECO:0000250|UniProtKB:P01130}. Lysosome {ECO:0000250|UniProtKB:P01130}. Note=Rapidly endocytosed upon ligand binding. {ECO:0000269|PubMed:12169628}.
Sequence: MSTADLMRRWVIALLLAAAGVAAEDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRCNSSICIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVATCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHRCEDIDECQEPDTCSQLCVNLEGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVNLVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPGLSTVASVTVSHQVQGDMAGRGNEEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLKNINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA
InterPro domains: - IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [400-659]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [284-394]
- IPR001881: EGF-like calcium-binding domain (domain) [315-394]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [355-378]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [369-380]
- IPR000033: LDLR class B repeat (repeat) [420-656]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [355-393]
- IPR051221: Low-density lipoprotein receptor-related (family) [24-732]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [121-314]
- IPR000742: EGF-like domain (domain) [26-713]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [20-309]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [26-316]
Interaction partners: - Low density lipoprotein receptor adapter protein 1
- E3 ubiquitin-protein ligase MYLIP
- Proprotein convertase subtilisin/kexin type 9
- Apolipoprotein B-100
- Disabled homolog 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038024 (cargo receptor activity), GO:0030228 (lipoprotein particle receptor activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0034185 (apolipoprotein binding), GO:0042277 (peptide binding), GO:0048306 (calcium-dependent protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005041 (low-density lipoprotein particle receptor activity), GO:0001540 (amyloid-beta binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0050773 (regulation of dendrite development), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0000902 (cell morphogenesis), GO:1900006 (positive regulation of dendrite development), GO:0031325 (positive regulation of cellular metabolic process), GO:0016358 (dendrite development), GO:0021517 (ventral spinal cord development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0021510 (spinal cord development), GO:0030030 (cell projection organization), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0031344 (regulation of cell projection organization), GO:0051246 (regulation of protein metabolic process), GO:0032990 (cell part morphogenesis), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0031346 (positive regulation of cell projection organization), GO:0051247 (positive regulation of protein metabolic process), GO:0007417 (central nervous system development), GO:0048813 (dendrite morphogenesis), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0051347 (positive regulation of transferase activity), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0010976 (positive regulation of neuron projection development), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0019220 (regulation of phosphate metabolic process), GO:0043549 (regulation of kinase activity), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0048812 (neuron projection morphogenesis), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0010975 (regulation of neuron projection development), GO:0045860 (positive regulation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)