Protein: Synaptobrevin (P18489)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q9W0C1}; Single-pass type IV membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27323327}; Single-pass type IV membrane protein {ECO:0000255}. Note=Neuronal synaptic vesicles (By similarity). In embryos, expressed in the plasma membrane of tracheal cells (PubMed:27323327). {ECO:0000250|UniProtKB:P63027, ECO:0000269|PubMed:27323327}.
Sequence: MENNEAPSPSGSNNNDFPILPPPPNANDNYNQFGDHQIRNNNAAQKKLQQTQAKVDEVVGIMRVNVEKVLERDQKLSELGERADQLEQGASQFEQQAGKLKRKQWWANMKMMIILGVIAVVLLIIVLVSVWPSSSDSGSGGGNKAITQAPPH
InterPro domains: - IPR001388: Synaptobrevin-like (family) [52-127]
- IPR042855: v-SNARE, coiled-coil homology domain (domain) [45-130]
- IPR016444: Synaptobrevin/Vesicle-associated membrane protein (family) [25-130]
Interaction partners: - Syntaxin-1A
- Synaptosomal-associated protein 25
- Synaptosomal-associated protein
- Alpha-soluble NSF attachment protein
- Synaptotagmin 1
- LD27967p
- Complexin
- Unc-13, isoform E
- Syntaxin-5
- Syntaxin-4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0051641 (cellular localization), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0051050 (positive regulation of transport), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0099536 (synaptic signaling), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0048731 (system development), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0001505 (regulation of neurotransmitter levels), GO:0016043 (cellular component organization), GO:0032940 (secretion by cell), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:0023061 (signal release), GO:0030100 (regulation of endocytosis), GO:0006836 (neurotransmitter transport), GO:0099504 (synaptic vesicle cycle), GO:0006887 (exocytosis), GO:0007399 (nervous system development), GO:0099643 (signal release from synapse), GO:0099537 (trans-synaptic signaling), GO:0046903 (secretion), GO:0033043 (regulation of organelle organization), GO:0007269 (neurotransmitter secretion), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0016079 (synaptic vesicle exocytosis), GO:0061024 (membrane organization), GO:0022607 (cellular component assembly), GO:0098916 (anterograde trans-synaptic signaling), GO:0099003 (vesicle-mediated transport in synapse), GO:0006906 (vesicle fusion), GO:0016050 (vesicle organization), GO:0048284 (organelle fusion), GO:0045055 (regulated exocytosis), GO:0061025 (membrane fusion), GO:0007268 (chemical synaptic transmission), GO:0090174 (organelle membrane fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031201 (SNARE complex), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0016324 (apical plasma membrane), GO:0030133 (transport vesicle), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0070382 (exocytic vesicle), GO:0030672 (synaptic vesicle membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0099501 (exocytic vesicle membrane)