Protein: Vitronectin (VN) (S-protein) (Serum-spreading factor) (P29788)
Organism: Mus musculus (Mouse)
Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Subcellular location: Secreted, extracellular space.
Sequence: MAPLRPFFILALVAWVSLADQESCKGRCTQGFMASKKCQCDELCTYYQSCCADYMEQCKPQVTRGDVFTMPEDDYWSYDYVEEPKNNTNTGVQPENTSPPGDLNPRTDGTLKPTAFLDPEEQPSTPAPKVEQQEEILRPDTTDQGTPEFPEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPGYPRNISEGFSGIPDNVDAAFALPAHRYSGRERVYFFKGKQYWEYEFQQQPSQEECEGSSLSAVFEHFALLQRDSWENIFELLFWGRSSDGAREPQFISRNWHGVPGKVDAAMAGRIYVTGSLSHSAQAKKQKSKRRSRKRYRSRRGRGHRRSQSSNSRRSSRSIWFSLFSSEESGLGTYNNYDYDMDWLVPATCEPIQSVYFFSGDKYYRVNLRTRRVDSVNPPYPRSIAQYWLGCPTSEK
InterPro domains: - IPR000585: Hemopexin-like domain (domain) [153-473]
- IPR018486: Hemopexin, conserved site (conserved_site) [195-349]
- IPR020436: Somatomedin B domain, chordata (domain) [19-59]
- IPR036024: Somatomedin B-like domain superfamily (homologous_superfamily) [21-67]
- IPR051298: Heme transport and cell adhesion protein (family) [119-474]
- IPR018487: Hemopexin-like repeats (repeat) [157-473]
- IPR001212: Somatomedin B domain (domain) [20-63]
- IPR036375: Hemopexin-like domain superfamily (homologous_superfamily) [144-477]
Interaction partners: - Integrin alpha-V
- Plasminogen activator inhibitor 1
- Urokinase plasminogen activator surface receptor
- Integrin beta-3
- Fibronectin
- Integrin alpha-IIb
- Integrin beta-1
- Urokinase-type plasminogen activator
- Nidogen-1
- Plasminogen
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0008201 (heparin binding), GO:0005178 (integrin binding), GO:0005102 (signaling receptor binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0031099 (regeneration), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0031100 (animal organ regeneration), GO:0043933 (protein-containing complex organization), GO:0061008 (hepaticobiliary system development), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0097421 (liver regeneration), GO:0001889 (liver development), GO:0051258 (protein polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)