wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Isoeugenol synthase 1 (PhIGS1) (EC 1.1.1.319) (Q15GI3)
Organism: Petunia hybrida (Petunia)
Function: Involved in the biosynthesis of the floral volatile isoeugenol. Catalyzes the synthesis of the phenylpropene isoeugenol from coniferyl acetate. Phenylpropenes are the primary constituents of various essential plant oils. They are produced as antimicrobial and antianimal compounds, or as floral attractants of pollinators. Isoeugenol is a characteristic aromatic constituent of spices and a floral volatile compound.
Sequence: MTTGKGKILILGATGYLGKYMVKASISLGHPTYAYVMPLKKNSDDSKLQLLKEFESLGVTIFYGELSEHDKLVAVFKEVDIVISTLAVPQYLEQLKVIEAIKEAGNIKRFVPSEFGNEVDRVRALPRFQAVLDNKKKIRRATEAAGIPFTFVSANSLTAYFVDYLLHPRQKSEQVTIYGSGDAKAVLNYEEDVAAYTIKAADDPRAANRVLIIKPPKNIVSQLDLVSSWEKTTGSTLKMTHISEQEIIKLSESINFPENIHASILHNIFIAGAQLSFELTQDHDLEASELYPNYNYTSVDEYLKICLVNPPKPKLATYAQPST
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [4-304]
- IPR050608: NmrA-type oxidoreductase, Isoflavone reductase subfamily (family) [4-304]
- IPR008030: NmrA-like domain (domain) [5-303]
- IPR045312: Phenylcoumaran benzylic ether reductase-like (domain) [7-302]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0018904 (ether metabolic process), GO:0009698 (phenylpropanoid metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:1901503 (ether biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0042537 (benzene-containing compound metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042537 (benzene-containing compound metabolic process), GO:0018958 (phenol-containing compound metabolic process), GO:0046189 (phenol-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Uncharacterized protein YgcP (Q46906)
Organism: Escherichia coli (strain K12)
Function: Not known
Sequence: MPLLHLLRQNPVIAAVKDNASLQLAIDSECQFISVLYGNICTISNIVKKIKNAGKYAFIHVDLLEGASNKEVVIQFLKLVTEADGIISTKASMLKAARAEGFFCIHRLFIVDSISFHNIDKQVAQSNPDCIEILPGCMPKVLGWVTEKIRQPLIAGGLVCDEEDARNAINAGVVALSTTNTGVWTLAKKLL
InterPro domains: - IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [2-189]
- IPR006699: Glycerol uptake operon antiterminator (family) [1-190]
Interaction partners: - Ferredoxin-like protein YgcO
- Probable electron transfer flavoprotein-quinone oxidoreductase YgcN
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0009112 (nucleobase metabolic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0046112 (nucleobase biosynthetic process), GO:0006206 (pyrimidine nucleobase metabolic process), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0019856 (pyrimidine nucleobase biosynthetic process), GO:0006207 ('de novo' pyrimidine nucleobase biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: AHA1, activator of heat shock protein ATPase homolog 1a (Activator of 90 kDa heat shock protein ATPase homolog 1a) (Q5RIK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MLIIGTERDVTSWSQDAINGLLLGIRVEGEEGTCEITDVSNIDGEASINNRKGKLIYFYEWVVKASWTGTNKIGIKYKGIVEIPNLSDENDMDDLDISVTLCKDQPNTPLTDLMRREGVKKIRMALGNYVKHLKTEFAQGMILPTENALFQQNQEAKAKVKLDKTQIGSPSTANAPSTGVKIATVSFSLKDTFLTSPEELYRIFITQEMVQAFTHLAAFVDGRCGGKFRLLEGNVHGQFAELIPDKKIAMRWRFASWPAGHAATVILNFVNQGSETELILEAKGVPSNEEERMKEGWQRYYFNAIKQTFGFGALLY
InterPro domains: - IPR015310: Activator of Hsp90 ATPase AHSA1-like, N-terminal (domain) [6-141]
- IPR023393: START-like domain superfamily (homologous_superfamily) [182-312]
- IPR036338: Activator of Hsp90 ATPase, Aha1 (homologous_superfamily) [6-142]
- IPR013538: Activator of Hsp90 ATPase homologue 1/2-like, C-terminal (domain) [195-309]
Interaction partners: - Stress-induced-phosphoprotein 1
- Heat shock protein HSP 90-alpha 1
- Prostaglandin E synthase 3
- Heat shock protein 90, alpha
- Peptidyl-prolyl cis-trans isomerase D
- Peptidylprolyl isomerase G
- peptidylprolyl isomerase
- Endoplasmin
- Heat shock protein HSP 90-beta
- Cysteine and histidine-rich domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0031072 (heat shock protein binding), GO:0051879 (Hsp90 protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:1904888 (cranial skeletal system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0048702 (embryonic neurocranium morphogenesis), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Adenylate kinase isoenzyme 6 homolog (AK6) (EC 2.7.4.3) (Dual activity adenylate kinase/ATPase) (AK/ATPase) (Q584W4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03173}. Nucleus {ECO:0000256|HAMAP-Rule:MF_03173}.
Sequence: MQQPKGINILITGTPGTGKTSLAELLVEELEGFSRIDVGKVVKENEFYTEYDKEFDTHVIDEDDEGRLLDFMEPIMVQGGNHVVDYHSSELFPKRWFHLVVVLRTSTEVLFERLMDRKYGELKRNENMEAEIHGICEEEARGAYDEDIIIVRDNNTLEEMAATVSLIQSRVGSIQAV
InterPro domains: - IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-175]
- IPR020618: Adenylate kinase isoenzyme 6 (family) [6-175]
Interaction partners: - 40S ribosomal protein S14
- Adenosine kinase
- Adenosine kinase
- adenine phosphoribosyltransferase
- adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- Phosphodiesterase
- Pyruvate kinase
- DNA-dependent RNA polymerases, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016776 (phosphotransferase activity, phosphate group as acceptor), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0050145 (nucleoside monophosphate kinase activity), GO:0004017 (adenylate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0019400 (alditol metabolic process), GO:0019751 (polyol metabolic process), GO:0006059 (hexitol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein STAR1 (ABC transporter ABCI.12) (OsABCI12) (ABC transporter I family member 12) (Protein ALUMINUM SENSITIVE 1) (Protein SENSITIVE TO ALUMINUM RHIZOTOXICITY 1) (Q0D9V6)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Associates with STAR2 to form a functional transmembrane ABC transporter required for detoxification of aluminum (Al) in roots. Can specifically transport UDP-glucose.
Subcellular location: Membrane {ECO:0000269|PubMed:19244140}.
Sequence: MRRLGLSLHHDTSPSFAALACNQRPPPNGTVHACSKSRPPQLEPGKVGKKPIKKTMRIARIPTSIPPHLRLPLDLSAVSPMGSASEHDVREHLLDVDGVGEEGAAAAAGPKIRVRGLTRRSEARGEEILRGVDLDVPRGVVVGVIGPSGSGKSTLLRALNRLWEPAPGAVLLDGVDICGIDVLALRRKVGMLFQLPAMFDGTVADNVRYGPQLQGKKLTDAEVQSLLSLADLDPALCSKPASELSVGQAQRVALARTLANDPEVLLLDEPTSALDPISTQNIEEAIVRLKKTRGLTTVMVSHSVKQIQRIADLVCLLVAGEVVEVLPPSELSEAKHPMARRFLELS
InterPro domains: - IPR005670: Phosphate import ATP-binding protein PstB-like (family) [112-331]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [244-258]
- IPR003593: AAA+ ATPase domain (domain) [138-321]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [108-345]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [112-344]
Interaction partners: - UPF0014 membrane protein STAR2
- ATP-dependent transporter ycf16, putative, expressed
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015695 (organic cation transport), GO:0015846 (polyamine transport), GO:0015847 (putrescine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: DNA polymerase IV (Pol IV) (EC 2.7.7.7) (Q74CQ6)
Organism: Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|HAMAP-Rule:MF_01113}.
Sequence: MSNHRTILHLDMNAFFASVEQQADPSLQGKPVAVIGSGARTIITTASYEARAHGVGTGMTTHEAKRLCPELILVIGNNREYTRISKLIFEMLGQFTPLVEVFSIDEAFLDLTGSLRLFGRADVIAREIKARIRDRFGLTCSIGIAPNKLLAKLASDMQKPDGLTIIPPENVASLMKTTPIRSLCGIGPSTEQRLKYLGISTCNDLGHFSSKILTRHFGAMGARLKQMGQGIDDSPVIPTTTEEEVKSVSHSTTLDHDLTNKDDIHKYLLMLSEMVGRRARRYKTKGKTVTLTIRYADFTTFSRQETLPSPLNRSGDIYRAVTALLDTLQLTQPIRLLGVAISNLVHASEQLPLFPEERRLTTLSQAMDQVNDRFGETTITFGTLLGQDNCSHVIAPAWRPAGIRDVKVK
InterPro domains: - IPR017961: DNA polymerase, Y-family, little finger domain (domain) [246-351]
- IPR043502: DNA/RNA polymerase superfamily (homologous_superfamily) [3-236]
- IPR001126: UmuC domain (domain) [7-187]
- IPR043128: Reverse transcriptase/Diguanylate cyclase domain (homologous_superfamily) [7-167]
- IPR022880: DNA polymerase IV (family) [4-353]
- IPR036775: DNA polymerase, Y-family, little finger domain superfamily (homologous_superfamily) [242-351]
- IPR053848: DNA polymerase IV/DNA polymerase iota-like, thumb domain (domain) [182-232]
- IPR050116: DNA polymerase type-Y (family) [3-364]
Interaction partners: - LexA repressor 2
- Beta sliding clamp
- Protein RecA
- DNA-directed DNA polymerase
- LexA repressor 1
- DNA repair protein RecN
- DNA helicase RecQ
- UvrABC system protein A
- DNA polymerase I
- Pyruvate:ferredoxin oxidoreductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0006950 (response to stress), GO:0009991 (response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus), GO:0009432 (SOS response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0042575 (DNA polymerase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups)
Protein: Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5) (RB intron encoded G-protein coupled receptor) (P43657)
Organism: Homo sapiens (Human)
Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.
Subcellular location: Cell membrane {ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:36173926}; Multi-pass membrane protein {ECO:0000269|PubMed:18297070}.
Sequence: MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [34-291]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [19-299]
Interaction partners: - Lysophosphatidic acid receptor 3
- Lysophosphatidic acid receptor 1
- Lysophosphatidic acid receptor 2
- Guanine nucleotide-binding protein subunit alpha-12
- Lipase member H
- Muscarinic acetylcholine receptor M1
- Lysophosphatidic acid receptor 5
- Lysophosphatidic acid receptor 4
- Angiotensinogen
- Proteinase-activated receptor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: glucuronosyltransferase (EC 2.4.1.17) (D3XD69)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004389}.
Sequence: MPVPSSTHGHPKMGLVAFIWCIVLTFASAGEAVKSKEASWTGSLLVVPMDGSHWTGVKALAEEMGRRGHKVTVVIPEVSVLLGPGKHYVTRTFPVLYGKQQLDELQARNAQVMESKQLPLMEKISTRFSNMRKFVNLQRATAESLLLNQELVDFLRKQNFDAVLTSPAVPTGAILAYNLSLPAVYMLRGLPCGLDSVATACPNPPSYIPRFFTHSSDRMSFGQRVLNVLVSMLEPLLCRLIYWTTEDVASRFMQRDVSVTEVLSSGALWLLRYDFTLEFPKPLMPNMVLIGGINCAIRHPLTKEVEEFVNGSGEHGIVVFSLGSLVSSMPKEKADIFFKAFSMIPQRVLWRYTGEIPNNVPENVKLMKWLPQNDLLGHPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVATRGVGVILSIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLRPAAHELNWLQYHSLDVIGFMLLIVLIVTLAMLKCCSLCWRRCCRKTQKRKED
InterPro domains: - IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [42-538]
- IPR035595: UDP-glycosyltransferase family, conserved site (conserved_site) [369-412]
- IPR050271: UDP-glycosyltransferase (family) [52-516]
Interaction partners: - Mitochondrial pyruvate carrier
- Cytochrome P450, family 3, subfamily A, polypeptide 65
- Aldehyde oxidase 6
- Xanthine dehydrogenase/oxidase
- Aromatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0015020 (glucuronosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 1-deoxy-11-beta-hydroxypentalenate dehydrogenase (EC 1.1.1.340) (Neopentalenolactone biosynthesis protein F) (Q82IY9)
Organism: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Function: Catalyzes the oxidation of 1-deoxy-11-beta-hydroxypentalenic acid to 1-deoxy-11-oxopentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
Sequence: MHLQPSTAVVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGAVEELAAHGADVTAVVADLTDPAAVQELADTAFGRLGDIDVVCNNAGVVGPVGMPLWSVPLDEMHAVFDVNYWAHVHVARAFVPRLLDSGRPSHLVQTASMSAFVVGAGTASYAASKHADLAAARSLRADLDGTPVRVSVLCPGRVDTPMTRGLVAPRNATGNTTISADEAADAVWNALGSDRFYIFTNADAQTRLGDQFNDVWRHLAREKYWTESSSPSVNSSRP
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1-230]
- IPR057326: Ketoreductase domain (domain) [6-193]
- IPR054968: 1-deoxy-11-beta-hydroxypentalenate dehydrogenase (family) [10-255]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [7-199]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009698 (phenylpropanoid metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009699 (phenylpropanoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)