Protein: GREB1-like protein (B8JKP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a major role in early metanephros development.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Sequence: MGNSYAGQLKSARFEEALHNSIEASLRSSGGDPQPVFTQLYLEPDQYSGHVEDIKPKMDLSLRSDPSTHVLVKCHSSNSVEDMDDEDDSDTSSPPLPYLQGPPPDGCCTVDGFCQAGKDLRLVSMATESIEVPAGFELVGAKSPSIPEHILVCAVDKRFLPDENGKNALLGFSGNCVGCGEKGFRYFTEFSNHINLKLSTQPKKQKHLKYYLVKNSQGALCKGALICWKDCKTRPFSNSASSSKPSSSSSLSSKENGDTNGHSPSPFPLSDSPPARMQSGSSSGIFGPQELGFLKPLNTPTHGTKTLPIVPTALRVNGLTNGLSMDGRSTLLSPPRTNPLSTPSHGYRTTETGDSPASTAMSTGPPKKRHRSWHPTTLVPIPATAVPVPAIRPLTCSSGPLLSLSNQQPASVSGVIQPQPITAGETVIIPDNLLNSYGVRPVLLIGQGTLPYFFGNVGDLVVSPLLVSCYKGRELNEKTLASLGMSANQLLTTETMILLTLQYLARLGTEQIPLREEFEQIMLKAMLCGPTGPPVSPAQLPWLARMEASVSGGSVQVLVTHGSLGEGISESLRSLSETSPQQQQCLPNYVLIICTSKSGANEFCVLVLGKYQSRALAESMLSTNEFLKEISYELITGKVSVLASHFQSTSLGDNMDKQLVRYQRKRKDRVVQPFQGHLTEYIHSQEAATMIPESGPDLLSDDFQIHPPQLSVARSLLSQVCAIADSGSQSLDLGRFCKVDFLILVPPSHVLVHQTVQRIRQSGVLIDLGIEDVSLAMQKSDKYVVRLDTEVHTKMEAFMRKVKQNPYTLFVLIHDNSHVDLTSALSGSVCHGELQGLADRVVNCPEVLEAINLLVLQVSCFPFTLQSRQSRISTQNEVHWPDTENQQGEASPKDLIYFGLKDYSKSLQWGVASPILRCDDAFERMVKTLLERHPHLHSMVIRSYLLIQQYTEALMALTAAPSLRDHVTPQTLAMVEDLLSVPGRSKHGCGHMLLVRVPSLQLARLAQERLEEARDKLGLQYRFAVLLGSPAAEISLPVHFCARLRAWRGCKNEEWVPHTYEDLEGLPCIVILTGKDPLGETFPRSLKYCDLRLIDSSYLTRTALEQEVGLACSYVTRRVIPKTKTATSREERPREGERSSGETAEHDDLPMELERPPSNASAATRTSGSTTENGVSSSSILDKPSSQSDPCGSRTMMDSCSSPVRFKQECDSQAPSSSSTSSFSSASSSSSSSSSPAAQRPSQSTQAPRECNRTQVFPRTAVLSRAAYTLLAPETLGHPSSASLLPHADVSWSSPLRPPVPHGLGGAEQSLYYRQWTTARQHHADYEGPVPHPHPRRLLLSGPPQVGKTGAYLQFLRILFRMLIRLLEVDVYDEEELEEDVQDKSKVPPSSGPQWPDVEDVRKLRFDLCPHDCKFKYSSPVYANRMPKTQSGVKTERLDTEADPPKRNTVSVRLSLFAAHNAFHHCEQCHHYSEPIPAAQLSDCTFHAFTFCSSMLGEEVQLHFIIPKSKESHFVFSQQGSHLESMRLPLLSDKESGMMKSPIFTPTTGRQEHGLLNIYHAMEGAEHLHILVVKQYEMPLYRKYWPNHILLVLPAMFNNSGVGAARFMIKELSYHNLELERNRQEEQGVKRQDVWPFIVMMDDSCVLWNAQQPGPDGKTEVMNVSLKSVLQHMEATPKISQYAVCGLRKWSSSLSSQAPTSPFSRCHLHDLILLNVDLTQNVQYDLNRFTCEEVDFNLRANSSGLLLCRFNQFSIMKKHIPIGGHKDFLIKPKLMRIETPVRVCASQYVCAPDSEQTLLAAPAQFLLEKFLQSCSHRLFPLALSNSANPVLSIDSYLNLGPEVQVCYVSSRPHSVNVDHQGVIFSGLLLYLCDSFVVSSLLKKFNFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANCSEDRPLYFLTGRHI
InterPro domains: - IPR048657: GREB1-like, circularly permuted SF2 helicase domain (domain) [703-1374]
- IPR046927: GREB1-like, C-terminal domain (domain) [1780-1942]
- IPR028422: GREB1 (family) [1-1942]
- IPR046926: GREB1, N-terminal domain (domain) [80-229]
- IPR048659: GREB1-like, second domain (domain) [359-647]
- IPR049100: TET-Associated Glycosyltransferase (domain) [1542-1760]
Interaction partners: - A-type potassium channel modulatory protein DPP6
- Transmembrane protein 241.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048729 (tissue morphogenesis), GO:0021536 (diencephalon development), GO:0009888 (tissue development), GO:0060322 (head development), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0035270 (endocrine system development), GO:0007420 (brain development), GO:0021983 (pituitary gland development), GO:0007417 (central nervous system development), GO:0002009 (morphogenesis of an epithelium), GO:0007399 (nervous system development), GO:0060429 (epithelium development), GO:0060026 (convergent extension)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)