Protein: Importin beta-like protein kap113 (Karyopherin-113) (O94545)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in the export of mRNA from the nucleus to the cytoplasm. May play a role in mitotic spindle formation and/or function.
Subcellular location: Nucleus {ECO:0000269|PubMed:15116432, ECO:0000269|PubMed:16823372}. Note=Nuclear rim.
Sequence: MQVDPVVYQLQRAVSQDPIAVKDAEGHLNNWKKEPGFFGKLYSIFLDKQNDMSLRWIAIIQLRNSIDIIWRKNTKMSLLPEERDFIRCNALLGSIKSENLLSIQNALVVSRIARLDYPTEWPSLFHDLLGKLQQSLGTGDYDVALRLLITLHHIIKAMAGNRLLRSRQIFYKLAPELLTILQPILHSSLSSWMMILESSKEIKDSTLLSYMQISRYTLKACRRLVVFGFQNPSESEFSERMLAFCAVHQRKLLSMLGTMLQSSRSPIVVGECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATIDYISLHYDFLGQISSHLSSYKEKFEESSKNFEKLVIMSLRVFILVIQEFCNTKSSHPETAQVLYNSFLVDNRINNLLDLLITKLLILKEEDFEEWTDSPQQWVLEQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFECPKTLTQAVQQDTLISSFGVGYTQLKSIFPFAKWLQEAAVPNMASINDIGISRVYRRRIAIFLSQWIEDSSSEQLLEVIYKLYCSFLNLTDPCNDAVVILTTIDAFKTVLDDWNFSENSFLSIKENLFVHVLSLFKAFESVDARTSILSLLGTLLARAGEHVAPMESTIASLLSQLWDGWKKEPLLRARVLAVMHQFVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKLPETFTLLIPHLLYHLSQATSTLPFVLMIVSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKNETLQALCKTVCLLIETTPMDMIYESLLNSSLLSRLLLSIATNDKHPQVLIEYLLVVSRISLREPELILKVCQTKNINIAMLIGNWILLNDHINHSKDRKLNTLALSSLLRTNHPDVLAVLDSIMNLWFSVLSEVEEDANGDATIYYKNDDYSAVGFYLDETSEEMTRRKQLLLKDPVHSVNSRSFFISVFMFCRDANGGMENFQNQYLSTVNPALLEQFQSML
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [5-983]
- IPR013598: Exportin-1/Importin-beta-like (domain) [101-205]
- IPR001494: Importin-beta, N-terminal domain (domain) [24-96]
- IPR011989: Armadillo-like helical (homologous_superfamily) [7-983]
Interaction partners: - Importin subunit beta-5
- Importin subunit beta-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140104 (molecular carrier activity), GO:0140142 (nucleocytoplasmic carrier activity), GO:0061608 (nuclear import signal receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0006913 (nucleocytoplasmic transport), GO:0006611 (protein export from nucleus), GO:0051168 (nuclear export)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)