Protein: Nuclear pore membrane glycoprotein 210 (Nuclear pore protein gp210) (Nuclear envelope pore membrane protein POM 210) (POM210) (Nucleoporin Nup210) (Pore membrane protein of 210 kDa) (P11654)
Organism: Rattus norvegicus (Rat)
Function: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Sequence: MARASLIQPGLWALLLLQAVGPAVAAKLNIPKVLLPFTRATRVNFTLEASEGCYRWSSTRPEVASIEPLGSSEQQCSQKAVVQARLTQPARLTSIIFAEDITTGQVLRCDAIVDLIHGIQIVSTTRELYLEDSPLELKIQALDSEGNTFSTLAGLVFDWTIVKDTEANGFSDSHNALRILTFLESTYIPPSYISEMEKAAKQGDTILVSGMKTGSSKLKARIQEAVYKNVRPAEVRLLILENILLNPAYDVYLLVGTSIHYKVQKIRQGKITELSMPSDQYELQLQNSIPDPQGDPARPVAVLTQDTSRVTAMQMGQSNLVLGHRSIRMQGASRLPNSTIYVVEAGYLGFTVHPGDRWVLETGHLYAVTIEVFDRSSNKVYPSDNIRIEAVFPAEFFEVLSSSQNGSYHHVRAIQSGQTTISASLTSVVDQDGGVHVLQVPVWNQQEVDIHIPITLYPSILTFPWQPKTGAYQYTIKAHGGSGNFTWSSSSYMVATVTVKGVMTTGGDTGLSVIRAHDVQNPLHFGEMKVYVIEPSSMEFAPCQVEARVGHTLELPLTISGLMPGGSSEVVTLSDCSHFDLVVEVENQGVFQPLPGRLPPGPEHCSGVKVRADAQGSTTLLVSYTHGHVHLGAKITLAAYLPLKAVDPSSVAVVTLGSSKEMLFEGGPRPWVLEPSKFFRNVTSEDTGSISLSLLGPPASRNYQQHRVLVTCQALGEQVIALSVGNRPSLSNPFPAVEPTVVKSVCAPPSRLTLMPVYALPQLDLSCPLLQQNKQVVPVSSHRNPLLDLGAYDQQGRRFDNFSSLSIQWESFRPLLASIEVDQPMQLVSQDDGNGQKKLHGLQTVSVHEASGTTAISATATGYQQSHLSAAGVKQLRDPLVPVSASIELILVEDVRVSPEEVTIYNHPGVQVELHITEGSGYFFLNTSTQDIINVAYQDTRGVAMVHPLFPGSSTVMVHDLCLTFPAPAKATIHVSDIQELYVRVVDKVEIGKAVKAYVRVLDFYKKPFLAKYFTFMDLKLRAASQIITLVTLDEALDNYTATFLVHGVAIGQTSLSASVTDKSGQRVSSTAQQIEVFPPFRLIPRKVTLIIGAMIQITSEGGPQPQSNILFSINNESVAAVSSAGLVRGLMVGNGSVLGVVQAVDAETGKVIIVSQDHVEVEVLQLQAVRIRAPITRMRTGTQMPVYVTGITSNQSPFSFGNAVPGLTFHWSVTKRDVLDLRGRHHEVSIRLSPQYNFAMNVHGRVKGRTGLRVVVKALDPTAGQLHGLGKELSDEIQIQVFEKLRLLNPEVEAEQILMSPNSFIKLQTNRDGAAILSYRVLDGPEKAPIVHIDEKGFLVSGSGIGVSTLEVIAQEPFGTNQTVLVAVKVSPISYLRISMSPVLHTQHKEVLTALPLGMTVTFTVHFHDSSGDIFHAHNSDLNFATNRDDFVQIGKGATNNTCIIRTVSVGLTLLHVWDVEHLGLSDFVPLPVLQAITPELSGAVVVGDILCLASVLISLGGVSGTWSSSAGNVLYVDPKTGVAIARDAGPVTVYYEIAGHLKTFKEIVVVTPQKIVARRLHATQTSIQEATASKVTVSVGDRSSNLLGECSSAQREAIEALHPESLISCQLQFKQDVFDFPARDIFSVEPGFDTALGQYLCSVTMHRLTDKQLKHLNMKKTSLAVTASMPSSRTSVEKVGAEVPFSPGLYANQAEILLSNHYPSSEVKIFGAVEILENLEVRSGSPAVLASVKEKSFGLPSFITYTVGVLDPTAGSQGPLSTALTFSSPATNQAITIPVTVAFVLDRRGPGPYGASLLSHFLDSYQVMFFTFFALLAGTAVTIIAYHTVCAPRELASPLALTPHASPQHSPHYLASSPTAFNTLPSDRKASPPSGLWSPAYASH
InterPro domains: - IPR057586: NUP210-like, Ig-like domain 16 (domain) [1477-1548]
- IPR055096: NUP210, Ig-like domain 1 (domain) [26-114]
- IPR003343: Bacterial Ig-like domain, group 2 (domain) [1077-1152]
- IPR055099: NUP210, Ig-like domain 7 (domain) [645-747]
- IPR055097: NUP210, Ig-like domain 2 (domain) [123-232]
- IPR055094: NUP210, Ig-like domain 15 (domain) [1371-1474]
- IPR055098: NUP210, Ig-like domain 3 (domain) [241-344]
- IPR056898: NUP210, Ig-like domain 6 (domain) [538-626]
- IPR045197: Nuclear pore membrane glycoprotein 210-like (family) [11-1859]
- IPR056899: NUP210, Ig-like domain 9 (domain) [897-975]
- IPR056897: NUP210, fourth Ig-like domain (domain) [355-433]
- IPR055095: NUP210, C-terminal Ig-like domain (domain) [1578-1719]
- IPR008964: Invasin/intimin cell-adhesion fragments (homologous_superfamily) [447-532]
Interaction partners: - Nucleoporin NUP35
- Nuclear pore complex protein Nup98-Nup96
- Nuclear pore complex protein Nup155
- Nucleoporin NUP188
- Nucleoporin 205
- Nuclear pore complex protein Nup85
- Nuclear pore complex protein Nup93
- Nuclear pore complex protein Nup107
- LOC683983 protein
- Nuclear pore complex protein Nup88
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)