Protein: Mothers against decapentaplegic homolog (Q8AY15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
Sequence: MSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQDVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLQSHHELRAIELCEFAFHMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPSEFPPLDDYSHSIPENTIFPAGIEPQSNYIPETPPPGYISEDGETSDHQMNRSMDTGSPNLSPNPVSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
InterPro domains: - IPR036578: SMAD MH1 domain superfamily (homologous_superfamily) [8-134]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [176-416]
- IPR013790: Dwarfin (family) [3-425]
- IPR001132: SMAD domain, Dwarfin-type (domain) [230-425]
- IPR017855: SMAD-like domain superfamily (homologous_superfamily) [223-425]
- IPR013019: MAD homology, MH1 (domain) [9-135]
- IPR003619: MAD homology 1, Dwarfin-type (domain) [25-133]
Interaction partners: - Mothers against decapentaplegic homolog 2
- receptor protein serine/threonine kinase
- Mitogen-activated protein kinase
- Mothers against decapentaplegic homolog
- Mothers against decapentaplegic homolog
- Zinc finger FYVE domain-containing protein
- Zinc finger FYVE domain-containing protein 9 isoform X1
- Forkhead box protein O1-A
- TGF-beta receptor type-2
- E3 ubiquitin-protein ligase CHIP
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0080090 (regulation of primary metabolic process), GO:0030097 (hemopoiesis), GO:0048568 (embryonic organ development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0007498 (mesoderm development), GO:0010468 (regulation of gene expression), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0035162 (embryonic hemopoiesis), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032924 (activin receptor signaling pathway), GO:0060215 (primitive hemopoiesis), GO:0038092 (nodal signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)