Protein: Zona pellucida-binding protein 2 (ZPBP-like protein) (Q6X784)
Organism: Homo sapiens (Human)
Function: Is implicated in sperm-oocyte interaction during fertilization.
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q6X786}. Secreted {ECO:0000305}. Note=Released after the acrosomal reaction. {ECO:0000250|UniProtKB:Q6X786}.
Sequence: MMRTCVLLSAVLWCLTGVQCPRFTLFNKKGFIYGKTGQPDKIYVELHQNSPVLICMDFKLSKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAETQEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSCHVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDRIEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCSPATFSPDVNVTCQTCVSVLTYGAKSCPQTSNKNQQYED
InterPro domains: - IPR007110: Immunoglobulin-like domain (domain) [21-127]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [36-130]
- IPR010857: Zona-pellucida-binding (family) [2-326]
- IPR048806: Zona-pellucida-binding protein 1/2, N-terminal domain (domain) [39-138]
- IPR048805: Zona-pellucida-binding protein 1/2, C-terminal domain (domain) [278-327]
Interaction partners: - Gasdermin-B
- Zinc finger protein Aiolos
- ORM1-like protein 3
- Growth factor receptor-bound protein 7
- Leucine-rich repeat-containing protein 3C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0009566 (fertilization), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0002683 (negative regulation of immune system process), GO:0035036 (sperm-egg recognition), GO:0008037 (cell recognition), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0007339 (binding of sperm to zona pellucida), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0048515 (spermatid differentiation), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0009988 (cell-cell recognition), GO:0007283 (spermatogenesis), GO:0006629 (lipid metabolic process), GO:0002701 (negative regulation of production of molecular mediator of immune response), GO:0001675 (acrosome assembly), GO:0002697 (regulation of immune effector process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0002698 (negative regulation of immune effector process), GO:1901575 (organic substance catabolic process), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0007338 (single fertilization), GO:0010256 (endomembrane system organization), GO:0007286 (spermatid development), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0010468 (regulation of gene expression), GO:0006665 (sphingolipid metabolic process), GO:0022607 (cellular component assembly), GO:0006643 (membrane lipid metabolic process), GO:0002637 (regulation of immunoglobulin production), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0010629 (negative regulation of gene expression), GO:0033363 (secretory granule organization), GO:0070925 (organelle assembly), GO:0016050 (vesicle organization), GO:0046466 (membrane lipid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)