Protein: RNA-binding protein vts1 (Q9P6R7)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q08831}. Cytoplasm, P-body {ECO:0000250|UniProtKB:J9VVN9}.
Sequence: MEVVEGRRKTCLDVVDSPSSRQKQTIAVSLVDGKNYPTRFLNSRTIDKLKQELNTSNLSTGEMSTNETLKNAQEVAGKLLSEENEDSISEHFDEYLGADKPGISFLTRLKTLESWFQSLSLQDRLTTLRTLLHHLPSQEISTLLSSSLTSSPSNSGLSLDKSLPSSPKGDSPSLSSSLPSLTTKSNLSGNLNMVTPASTQGPAFSSKHGFSNALSTASPIPVRTSSVSSTYLTQDREASSKNCLSKALAFSSIEPPASSASTSPRNTPTPSNNGTSINANVTSSLTSNSTGKTSKTTDLLIAASKKSLPSNSTPSKPNTSFFETPHNNIWDSRDRGAFSAPPAPFFPLGFSPHLNDESSRSRWSNISYSPPPPPPPPELLNHSPKSRPLGDKPYLFYRNNQIGPRTRTEGRSSITEGKPFLSSSLRFEHVPSANDLNSVVNARVEKSTGQPSTPLNRQHYFNELPHSTTPVTLPSLIHGSEIDRRRSGFCLNNFNSTPPFQPYHYEIGSGLPQQMHATNTILTNPIDPNSNISTPVGMHLCTLPYTYQPFSSVEKIETPPNNSKNQTYRRSSRGSNKTRKSISHSKNTDKHVGNELPQDIPSWLRSLRLHKYTNNLKDTDWDALVSLSDLDLQNRGIMALGARRKLLKSFQEVAPLVSSKKMNENLKAAKNQSSESLTSFKGHTDSEDLPSGSMSNEISSNSTKQDVSSSSMD
InterPro domains: - IPR037635: VTS1, SAM domain (domain) [592-660]
- IPR001660: Sterile alpha motif domain (domain) [592-656]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [581-665]
- IPR050897: SMAUG/VTS1 RNA-binding (family) [88-673]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0034248 (regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0006996 (organelle organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0017148 (negative regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0140694 (non-membrane-bounded organelle assembly), GO:0033962 (P-body assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)