Protein: Protein US2 (P13292)
Organism: Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Function: Plays a role in the activation of the host NF-kappa-B pathway by interacting with and thus activating the component MAP3K7.
Subcellular location: Virion {ECO:0000269|PubMed:23785212}. Host cytoplasm {ECO:0000269|PubMed:23785212, ECO:0000269|PubMed:9820154}. Host cell surface {ECO:0000269|PubMed:23785212}. Host nucleus {ECO:0000269|PubMed:9820154}. Note=Found in association with the nuclear matrix of infected cells.
Sequence: MGVVVVSVVTLLDQRNALPRTSADASPALWSFLLRQCRILASEPLGTPVVVRPANLRRLAEPLMDLPKFTRPIVRTRSCRCPPNTTTGLFAEDDPLESIEILDAPACFRLLHQERPGPHRLYHLWVVGAADLCVPFFEYAQKTRLGFRFIATKTNDAWVGEPWPLPDRFLPERTVSWTPFPAAPNHPLENLLSRYEYQYGVVVPGDRERSCLRWLRSLVAPHNKPRPASSRPHPATHPTQRPCFTCMGRPEIPDEPSWQTGDDDPQNPGPPLAVGDEWPPSSHVCYPITNL
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [25-119]
- IPR003485: Herpesvirus US2, varicellovirus-type (family) [1-202]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0070401 (NADP+ binding), GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor), GO:0017076 (purine nucleotide binding), GO:0004146 (dihydrofolate reductase activity), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0042398 (cellular modified amino acid biosynthetic process), GO:0006760 (folic acid-containing compound metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0042559 (pteridine-containing compound biosynthetic process), GO:0046653 (tetrahydrofolate metabolic process), GO:0009396 (folic acid-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)