Protein: Secreted aspartic protease 7 (Q59VH7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors (By similarity). These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense (By similarity)
Subcellular location: Secreted
Sequence: MQRVLELLLLSSTALAVIGDGFIALPVHKLQAGEGSAHFPNRLPIFDVVNGVAKSVEDDVNQIIQPIFGNGIFSGGSIQGTHSGNGHSVKYEVSLPSSSSQKGSNGPSSTDNKDTDPSKTGFSLDDLMNSIPTDFWNLIGLNKAPTSSDNGSKDADFTPSAVSQVEQPTSKSVESTAPGPASSASSSSSSEAASSSQPSEDSQPSSSANKKTGAFFLSLDNTQTLYTATLKVGSPAQEVQVMIDTGSSDLWFISSGNSQCKVNGGSIDCDKYGVFDKSKSSTWHDNKTDYSISYYDGDKASGTMGQDNITFADGFSIENANFAVIDNTTSSIGVFGVGYPELEAVKSKYTNLPFAMKEQNLIAKVAYSLYLDSRDAVQGYILFGGIDHAKYTGDLKAFDIVQSNDKYVYSQIPLTSVASSLNNYTNAYGLPAGSNHPKVGAVIYNGTDSFNGGVDLKDTPTLLDTGTTYSYLSKDQVESIVGLYGNVTYNDAGKAYEVPCWVGNPGNYLEFNFKNEQYIKVPTSEFVISVGTYASGAELCVFGILPGTHSILGDNFMRSVYAVFDLEDHVISIAQAAYNDNHAVVPIE
InterPro domains: - IPR001969: Aspartic peptidase, active site (active_site) [241-252]
- IPR033876: Secreted aspartic endopeptidase (domain) [224-576]
- IPR001461: Aspartic peptidase A1 (family) [186-575]
- IPR033121: Peptidase family A1 domain (domain) [226-576]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [211-587]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0070001 (aspartic-type peptidase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0009408 (response to heat), GO:0051701 (biological process involved in interaction with host), GO:0009266 (response to temperature stimulus), GO:0098630 (aggregation of unicellular organisms), GO:0010035 (response to inorganic substance), GO:1901564 (organonitrogen compound metabolic process), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0019538 (protein metabolic process), GO:0075136 (response to host), GO:0009268 (response to pH), GO:0090609 (single-species submerged biofilm formation), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0034599 (cellular response to oxidative stress), GO:0010038 (response to metal ion), GO:0036211 (protein modification process), GO:0052200 (response to host defenses), GO:0043412 (macromolecule modification), GO:0071241 (cellular response to inorganic substance), GO:0062197 (cellular response to chemical stress), GO:0042710 (biofilm formation), GO:0006796 (phosphate-containing compound metabolic process), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0071248 (cellular response to metal ion), GO:0090605 (submerged biofilm formation), GO:0046688 (response to copper ion), GO:0034614 (cellular response to reactive oxygen species), GO:0006468 (protein phosphorylation), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)