Protein: Choline/ethanolamine transporter FLVCR1 (B2RXV4)
Organism: Mus musculus (Mouse)
Function: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids (By similarity). Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane (By similarity). Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment
Subcellular location: [Isoform 1]: Cell membrane; Multi-pass membrane protein
Sequence: MARPDDEVGPAVAPGHPLGKGYLPVPKGAPDGEARLVPQNGPEALNGGPGLGPLIAGAQGGPQALIAAEEETQARLLPAGDGEDVPCPACPPRTALSPRRFVVLLIFSLYSLVNAFQWIQYSSISNVFEDFYEVSPLHINWLSMVYMVAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWVKCGSVQRHLFWVTMLGQILCSVAQVFILGLPSPVASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPALGTQNSTGLLAHTQNNTDLLAHNINTMFYGTAFISTFLFFLTIIAFKEKPPLPPSQAQAVLRDSPPEEYSYKSSIWNLCRNIPFVLLLVSYGIMTGAFYSISTLLNQIILTYYVGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYVLSFIGMLIFTFTLNLGYIIVVFFTGGILGFFMTGYLPLGFEFAVEITYPESEGMSSGLLNTAAQILGIFFTLAQGKITTDYNSPEAGNIFLCAWMFVGIILTALIKSDLRRHNINTGLTNIDVKAVPVDSRVDPKPKVMVSIQSESSL
InterPro domains: - IPR049680: Choline/ethanolamine transporter FLVCR1-2/SLC49-like (family) [93-529]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [87-524]
- IPR011701: Major facilitator superfamily (family) [109-482]
- IPR020846: Major facilitator superfamily domain (domain) [103-522]
Interaction partners: - Hemopexin
- Heme transporter HRG1
- ATP-binding cassette sub-family B member 10, mitochondrial
- Proton-coupled folate transporter
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048589 (developmental growth), GO:0050793 (regulation of developmental process), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0002520 (immune system development), GO:0035264 (multicellular organism growth), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0040008 (regulation of growth), GO:0048736 (appendage development), GO:0010171 (body morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0034101 (erythrocyte homeostasis), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0046620 (regulation of organ growth), GO:0009790 (embryo development), GO:0035107 (appendage morphogenesis), GO:0048534 (hematopoietic or lymphoid organ development), GO:0060323 (head morphogenesis), GO:0048638 (regulation of developmental growth), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0030218 (erythrocyte differentiation), GO:0042733 (embryonic digit morphogenesis), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0048536 (spleen development), GO:0035108 (limb morphogenesis), GO:0030099 (myeloid cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0030326 (embryonic limb morphogenesis), GO:0048706 (embryonic skeletal system development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)