Protein: Bromodomain adjacent to zinc finger domain protein 2B (A2AUY4)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (By similarity). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (By similarity). The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex (By similarity). Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
Sequence: MESGELLPSSPASSTTPTSSSAPSVASAVSKSSLSTGAASLSSTASPCVLEAGKSKIKVSPDSVSGAEWWRTTDGHSRAGTPFFPPLLGIPPLFAPPAQNHDSSFHSRTSGKSSRNGPEKGINGSVNGTSAASVLGVNASVVATPASSSMGQNQSTSSGGGTLKCHQEQNKSQPVDARADRIKDKKPRKKAMESSSNSDSDSGTSSDTSSEGISSSDSDDLEEEEEEDQSVEESEDDDSDSETEAQHKSNNQVLLHGISDPKTDGQKATEKAQERRTHQPLPPVSESQTHPPFQSQQKQPQVLSQQLPFIFQSSQAKEESVTKHTSVIQSTGLVSNVKPLSLVNQAKKETYRKLVVPSPDVLKAGNKNTSEESSSLTSELRSKREQYKQTFPSQGKKQEMGKSLKKVIAALSNTKATSSSPAHPKLPLDNNHPNPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENVSSSTPFSSPVNLSTSGRRAPGSQTPALPSASPILHSSGKEKRVSNDATPLKAHHHPHPAAAAAALVEQFRGTDSDVPSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSQSDSEGSEDDEEKDQEESDSDTEGEKPAVNLTQTSSSAKSPPSSLTAHSAPHLHIGSPPGSAPAALCSESQPPAFLGTSSSTLTSTPHSGTSKRRRVADDQELRIPLDYGWQRETRVRNFGGRLPGEVAYYAPCGKKLRQCPDMVKGMQWCLLKEEDVIPRIRAMDGRRGRPPNPDRPRAREESRMKRRKGRPPNVGSAEFLDNTDAKLLRKLQAQEIARQAAQIKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQMKIIKQQEKIKRIQQIRMEKELRAQQILEAKKKKKEEAANAKLLEAEKRTKEKELRRQQAVLLKHQERERRRQHVMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPKEDMCLADQKPLPEWPRIPGLVLSGTTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEVLQIFMEAHCGQTELTESLKTKAFQAHTPAQKASILAFLVNELACSKSVVSEIDKNIEYMSNLRRDKWMVEGKLRKLRIIHAKKTGKRDASGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQADEDEEDEEDKDDKKGKKTDICEDEDEGDQTASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSMMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEKEKLKKAESLQIKEEVFETSAETLNCSIRDHCEQKDDPKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESDVMTPPKVNVSTNGGPLSHQNSGKHPLGSVPSATTAQSPVGKTDASLFSSGSGSCGKFYSPLPNDQLLKTLTEKNRQWFSLLPKTPCDDTSLTHADLSTTLVTPQSQPPSKSPSPAPAALLGPSSVQSPPGLNPFALSPLQVKGGVSMMGLQFCGWPAGVLASNVPFTSPLPALGSGLGLPEGNGSSSFLTSSVASSKSDSPVPPAERPSSAQPVAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKTLLKVLHLRGIREKALQKQIQKHLDYITQACVRNKDVAIIELNENEDNQVTRDLVENWSVEEQAMELDLSILQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSLTKLFKEHDGELTGDEENSAHALARKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPAPAPSISGDGDGIEEDIAPGLRVWRRALAEARSAAQVALCIQQLQRSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACISKASGQSIKIKKIHVKGKKTNDSKKTKKGNVAGDTEDEDSASTSSSLKRGSKELKKRKMEETTSLNLSKAESTTSIKKPKKDESRDLALCSMILTEMETHEDSWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLNNGQYPNFETFALDVRLVFDNCETFNEDDSDIGRAGHSMRKYFEKKWTDTFKVS
InterPro domains: - IPR028941: WHIM2 domain (domain) [1290-1320]
- IPR018501: DDT domain (domain) [1004-1069]
- IPR016177: DNA-binding domain superfamily (homologous_superfamily) [691-743]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [1874-1940]
- IPR037374: BAZ2A/BAZ2B, bromodomain (domain) [2020-2116]
- IPR018359: Bromodomain, conserved site (conserved_site) [2037-2094]
- IPR019787: Zinc finger, PHD-finger (domain) [1886-1936]
- IPR001487: Bromodomain (domain) [2013-2121]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1854-1946]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [1947-2122]
- IPR001739: Methyl-CpG DNA binding (domain) [690-765]
- IPR001965: Zinc finger, PHD-type (domain) [1888-1934]
- IPR028942: WHIM1 domain (domain) [1109-1149]
Interaction partners: - WD repeat, SAM and U-box domain-containing protein 1
- DNA polymerase epsilon subunit 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0031325 (positive regulation of cellular metabolic process), GO:0072089 (stem cell proliferation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:0051962 (positive regulation of nervous system development), GO:0008284 (positive regulation of cell population proliferation), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:2000179 (positive regulation of neural precursor cell proliferation), GO:0072091 (regulation of stem cell proliferation), GO:0007417 (central nervous system development), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:2000177 (regulation of neural precursor cell proliferation), GO:1902692 (regulation of neuroblast proliferation), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0002052 (positive regulation of neuroblast proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)