Protein: Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (RIMS-binding protein 1) (RIM-BP1) (TSPO-associated protein 1) (Q9JIR0)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O95153}. Mitochondrion {ECO:0000250|UniProtKB:O95153}. Note=Preferentially expressed in the mitochondria in the presence of TSPO. {ECO:0000250|UniProtKB:O95153}.
Sequence: MEQLTTLPRLGDPGAMEPWALPAWQHWTQGQGCKPGDASASIAATPTALQVKGLRFEESSEPAGAHSPGPIRNTDPEGTETVLPKLGQQAESPGYSCSRLEGEDAQAYKAKFNIGFGDRPNLELLRALGELQQHCTILKEENQMLRKSSFPETEEKVRRLKRKNAELAVIAKRLEERAQKLQETNMRGGEVPLCPDPDPVWSCARKALARQRARDLSETATALLAKDKQNAALQRECRELQARLSLVGKEGPQWLHMRDFDRLLRESQREVLRLQRQIALRNQREPLRPARSQGSTAPSSVGAPAPGAPGETVLEDDVESPQVVLGEPEKQLRVQQLESELCKKRKKCESLEQEARKKQRRCEELELQLRAAQNENARLVEENSRLSGKATEKEQVEWENAELKGQLLGVTQERDSALRKSQGLQSKLESLEQVLEHMRKVAQRRQQLEEEHEQARLSLQEKQEEVRRLQQAQAEAKREHEGAVQLLESTLDSMQARVRELEGQCRSQTERFSLLAQELQAFRLHPGPLDLLTSALGCNALGDHPPPHCCCSSPQPCQGSGPKDLDLPPGSPGRCTPKSSEPALATLTGVPRRTAKKAESLSNSSRSESIHNSPKSCPTPEVDTASEVEELEVDSVSLLPAAPEGHSGGGARIQVFLARYSYNPFEGPNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLSTLPRELADSSHSSGPELSFLSGGGGGCSSGGQSSGGRSQPRPEEEATGDELSLSPPPEGLGEPLAVPYPRHITVLKQLAHSVVLAWELPPERVDLRGFHIFVNGELRQALGPGVPPKAVLENMDLRAGPLHVSVQALTSKGSSDPLRCCLAMGAGAGVVPSQLRIHRLTATSAEITWVPGNSNLAHAVYLNGEECPPARPSTYWATFCNLRPGTLYQARVEAQIPSQGPWEPGWERPELRAATLQFTTLPAGLPDAPLDVQAEPGPSPGIVMISWLPVTIDAAGTSNGVRVTGYAVYADGQKIMEVASPTAGSVLVEVSQLQLLQACHEVTVRTMSPHGESTDSIPAPVAPALASACQPARMSCLSPRPSPEVRTPLASVSPGLGYTSLPLRHPVPHGTQDSPASLSTEMSKGPQEEPPVPCSQEEAGSAVHRTSEEKRAMEPTLGQEGPDPVAPFLAKQAVECTSGDAGPTPCSTQEELTQKEPSTEVCHRGDLDSELKLRSEKEGMSELGVHLVNSLVDHSRNSDLSDIQEEEEEEEEEEELGSRPWSFQKQVAGNSIGENGAKPQPDPSCETDSDEEILEQILELPLQRLCSKKLFSIPEEEEEEDEEEGLGKPGPSSSSQDPSQPERALLGLDCESSQPQGPGLCPLSPELSGAREHLEDVLGVVGGNSRRRGGCSPEKLPNRKRPQDPREHCSRLLGNGGPQTSARPVPPRDRGSLPVIEGTRVGQEPGGRGRPGLSRRCPRGPAPESSLVSCLSPKCLEISIEYDSEDEQEVGSGGVSISSSCYPTDGEAWGTAAVGRPRGPVKVNSGSNTYLRLPAWEKGEPERRGRSAIGRTKEPPSRATETGESRGQDNSGRRGPQRRGARVLRTGTTELAPPRSPQEAPSHQDLPLRVFVALFDYDPISMSPNPDAGEEELPFREGQILKVFGDKDADGFYRGESGGRTGYIPCNMVAEVAVDTPTGRQQLLQRGFLPPNVLTQGSGNGPSVYPSAHTPGPPPKPRRSKKVELEDPAQLCPGPPKLIHSAALKTSRPMVAAFDYNPRENSPNMDVEAELPFRAGDVITVFGNMDDDGFYYGELNGQRGLVPSNFLEGPGPEAGGLDSGTSQAESQRTRRRRVQC
InterPro domains: - IPR057884: RIMS-binding protein 1/2/3, Fn3 domain (domain) [975-1076]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [883-1021]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [651-1820]
- IPR003961: Fibronectin type III (domain) [786-1064]
- IPR001452: SH3 domain (domain) [651-1823]
- IPR035755: RIMS-binding protein, third SH3 domain (domain) [1761-1820]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [980-1077]
- IPR040325: RIMS-binding protein 1/2/3 (family) [61-1842]
- IPR035753: RIMS-binding protein, second SH3 domain (domain) [1621-1682]
- IPR057950: RIMB1/RIM3A-C-like, N-terminal domain (domain) [118-244]
Interaction partners: - Translocator protein
- Regulating synaptic membrane exocytosis protein 1
- Regulating synaptic membrane exocytosis protein 2
- Protein unc-13 homolog B
- PTPRF interacting protein alpha 2
- Liprin-alpha-4
- Syntaxin-1A
- Protein lin-7 homolog B
- Ras-related protein Rab-3A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0051128 (regulation of cellular component organization), GO:0042391 (regulation of membrane potential), GO:0031338 (regulation of vesicle fusion), GO:0033043 (regulation of organelle organization), GO:1901632 (regulation of synaptic vesicle membrane organization), GO:0031630 (regulation of synaptic vesicle fusion to presynaptic active zone membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098793 (presynapse), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0044305 (calyx of Held), GO:0098978 (glutamatergic synapse), GO:0030424 (axon)