wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Geranylfarnesyl diphosphate synthase (GFPS) (EC 2.5.1.81) (Farnesylgeranyl diphosphate synthase) (FGPP synthase) (Q8PYS1)
Organism: Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Function: Involved in biosynthesis of the polyprenyl side-chain of methanophenazine, an electron carrier utilized for methanogenesis. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylfarnesyl diphosphate (GFPP). It prefers geranylgeranyl diphosphate (GGPP) and farnesyl diphosphate (FPP) as allylic substrate.
Sequence: MPVKVHGVILMNIEEWEEYRYVEAGIKESITLIEDPGLKKMVEHVCHSGGKRIRPIILLLVSEICSGSYSRSLNAALAVEMMHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDYLIAKSIAFISPYGEKVIQDFGKAGMDMAEGEVLDLKLEDESFGENDYFKCIYKKTASLFAISASIGAYTGGAEEELAERFSHFGNALGTAYQIVDDILEFLEVVEGKESKFTSETLPHIYMKSTSKEEALKKSIDCVKLHVAAAKETLETFRECPARDKLFQITDYITVDMLENL
InterPro domains: - IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [10-295]
- IPR000092: Polyprenyl synthetase-like (family) [33-288]
- IPR053662: Geranylfarnesyl diphosphate synthase-like (family) [11-295]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity), GO:0004311 (farnesyltranstransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0051761 (sesquiterpene metabolic process), GO:0046246 (terpene biosynthetic process), GO:0051762 (sesquiterpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (Q9D658)
Organism: Mus musculus (Mouse)
Function: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Subcellular location: Cell membrane. Early endosome.
Sequence: MARMNRPAPVEVSYRHMRFLITHNPSNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLLKAKFYNDPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1-169]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [82-148]
- IPR050561: Protein Tyrosine Phosphatase (family) [24-163]
- IPR020422: Dual specificity protein phosphatase domain (domain) [8-161]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [64-155]
Interaction partners: - Metal transporter CNNM3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0040017 (positive regulation of locomotion), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:2000147 (positive regulation of cell motility), GO:2000145 (regulation of cell motility), GO:0030335 (positive regulation of cell migration), GO:0030334 (regulation of cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: At1g69250 (F4N2.20) (Nuclear transport factor 2 (NTF2) family protein with RNA binding (RRM-RBD-RNP motifs) domain-containing protein) (Putative RNA-binding protein; 63745-61607) (Q9LDI9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MATEGVVPSAQDIAAEFVRQYYHVLGQLPHEARRLYVDASVVSRPDVTGTMMSFTSVEAINKHILSCDFENTKFEVLSVDSQNSLEDGIFIMVIGFMTGKDNQRRKFSQMFYLARQNTLVVLNDMLRYVDQEDSSTTETPCEPVTEIVRPADGLKKAEKTELKQKNVASVEKSVNAAVEKNAAPLDNGKMKQSEKAVITQKVTEPDAAPQPDGAKRSFADIVGSMAKNAAPFQVKSPVQAPVQKPKYVGQPRAAAAPQKPAYVSKSIKKNDQKVIEVPGTSIFVANLPLNAMPPQLFELFKDFGPIKENGIQVRSSRGNANPVCFGFISFETVASVQSVLQAAKNTPFMLADRKLRVKEKEVDYDGSKPSGKTKGGSNKTQNGSADSSKTENGSADDSKTNGSAEDGEKEFKQVKSRRNRKKSEAAH
InterPro domains: - IPR039539: Ras GTPase-activating protein-binding protein (family) [9-388]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [256-423]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [267-368]
- IPR002075: Nuclear transport factor 2 domain (domain) [13-128]
- IPR000504: RNA recognition motif domain (domain) [280-362]
- IPR018222: Nuclear transport factor 2, eukaryote (domain) [9-130]
- IPR032710: NTF2-like domain superfamily (homologous_superfamily) [9-129]
Interaction partners: - Ubiquitin carboxyl-terminal hydrolase 24
- RNA-binding
- Cysteine-rich receptor-like protein kinase 18
- Nuclear transport factor 2 family protein
- Zinc finger protein CONSTANS-LIKE 13
- NTF2-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0048585 (negative regulation of response to stimulus), GO:0032101 (regulation of response to external stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0002832 (negative regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0031348 (negative regulation of defense response), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:1900425 (negative regulation of defense response to bacterium), GO:1900424 (regulation of defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Transmembrane protein (Q581D5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MLRLRCLLCVPAVAGQRRVIMRSQSWVSVRYVGSSSRVHARFLGRGCSFGAALSEQHRWMRVGAHKRAAGSADETSQGGAEGEDGAPRGDRANTTSGIHSHIQGLKEDIRKFPDIYNSANAFNFILFTAFCLCSTGSNVEEKWWMDNWGIDATFAPWAWLLHSFMMNNFLSAAFSMLLLHTMCHSVLPTIGSRGLVIYCVITAVTSGFIMWVGNKLANNTSEKQFGPWDIVAALFVMQYLHQGFTPVQILNSFTGWLRYACWVGAVCIAYYDWQPTAVGTLMGLALCKGHPRFRVTTGAV
InterPro domains: - IPR035952: Rhomboid-like superfamily (homologous_superfamily) [113-289]
Interaction partners: - Acyl-CoA dehydrogenase, mitochondrial, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 3-beta-hydroxylase (Tp8878) (EC 1.14.14.-) (Cytochrome P450 71CB1) (X2EW55)
Organism: Tanacetum parthenium (Feverfew) (Matricaria parthenium)
Function: Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Component of the parthenolide biosynthetic pathway; parthenolide and conjugates are promising anti-cancer drugs highly active against colon cancer cells. Catalyzes the conversion of costunolide and parthenolide to 3-beta-hydroxycostunolide and 3-beta-hydroxyparthenolide, respectively.
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000255}.
Sequence: MFSSFETLILSFVSLFFMMIFIHSKWISSYSKMAKNLPPSPFGLPIIGNLHQLGMTPYNSLRTLAHKYGSLMLIHLGSVPVIVASSAEAAQEIMKTHDQIFSTRPKMNIASIVSFDAKIVAFSPYGEHWRQSKSVYLLNLLSTKRVQSFRHVREDETNLMLDVIENSCGSEIDLSNMIMSLTNDVVCRIAYGRKYYEDWFKELMKEVMDVLGVFSVGNYVPSLSWIDRLSGLEGRAYKAAKQLDAFLEGVVKQHETKSNESMRDQDVVDILLETQREQASAGTPFHRDTLKALMQEMFIAGTDTTSTAIEWEISEVIKHPRVMKKLQQELDEIAQGRQRITEEDLEDTQHPYLEAILKESMRLHIPVPLLLPREATHDVKVMGYDIAAGTQVLINAWMIARDPTIWEDADEFKPERFLDTNIDYKGLNFELLPFGAGRRGCPGIQFAMSVNKLALANLVYKFDFKLPNGLRLEQLDMTDSTGITVRRKYPLLVIPTARF
InterPro domains: - IPR001128: Cytochrome P450 (family) [38-479]
- IPR002401: Cytochrome P450, E-class, group I (family) [65-464]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [24-498]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [434-443]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0051761 (sesquiterpene metabolic process), GO:0046246 (terpene biosynthetic process), GO:0051762 (sesquiterpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Uncharacterized protein C8orf48 (Q96LL4)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAICPELAQTDKSALANLSDETETLKNSTDEVQTSSSFSSSGGRQSSPLTSGSKLEREKQTPSLEQGDTQSELLDYKNYEKKLSKKWINYLKLKDSNFERHQPDTKLPTEITRVSDEELNALQSYCTMKINLIHRRGDSKKKTSSRHKKLHLGLDVEASERDAFSCTVPDELLNRIYFKNMRTTPKQEAAAKQHISYQCPYCNRKRAELALSAFLKQKKTLLESFLLQERIDEHLHTKDFLTRIGEAHQDFPRLSDDPRIIWKRLTEKSHIRYSGFERSETEQKLQRDGNSACHLPFSLPFLKRLTLIKPELVIVNDNV
InterPro domains: - IPR027932: Protein of unknown function DUF4606 (family) [166-268]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Alcohol dehydrogenase (EC 1.1.1.1) (Q9NAR7)
Organism: Bactrocera oleae (Olive fruit fly) (Dacus oleae)
Function: Not known
Sequence: MGLSGKNVVFVGGLGFIGYEACKQIMTKNVASFFVFDVLENAENIKALQAINPKTKVYYTKFDITNKASIKSAFADVIAKVQYIDVLVNGAGILTDPNVELTMNINLIGLINTTLEAIPLMDKNKKGRGGLIVNIASVLGLEPAPPAAIYCASKFGVMGFSRSISDPYYYNLTGIAVATFCPGLTETPLKNNIATKYTFEYSKVIGDKLNNTKTQKPEACGAHLAQVLDTAENGGIYISNQGTLSKVTPTVYWQPTFN
InterPro domains: - IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [137-165]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1-247]
- IPR002426: Alcohol dehydrogenase, Ceratitis-type (family) [12-256]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [6-196]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0018455 (alcohol dehydrogenase [NAD(P)+] activity), GO:0004022 (alcohol dehydrogenase (NAD+) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006629 (lipid metabolic process), GO:0006082 (organic acid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006066 (alcohol metabolic process), GO:0006631 (fatty acid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0034308 (primary alcohol metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Viral late gene transcription factor 3 (VLTF-3) (Trans-activator protein A2) (P68319)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Acts with RNA polymerase to initiate transcription from late gene promoters.
Sequence: MNLRLCSGCRHNGIVSEQGYEYCIFCESVFQKCTKVQKKSNFHVSNKLIHLRNVLRRLLSHQCSGEIISELLDIMEKNQISTDDVDANFVSSFLKANERINKKDYKLVFEIINQVKDEKLNLSTEKINEVVEIFKHLVFFCQENTPSKTINYSFFLDKIFDITSVTKNLKPQTVKNYTKNNSNQLVWENFLAHMRSKKRVTMVEDYGHEYVFVDERFSTCSLEV
InterPro domains: - IPR014900: Viral late gene transcription factor 3 , zinc ribbon (domain) [1-32]
- IPR007031: Poxvirus VLTF3, late transcription factor (family) [38-197]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019080 (viral gene expression), GO:0019083 (viral transcription), GO:0039695 (DNA-templated viral transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0044094 (host cell nuclear part), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: GH11143p (Q8MR61)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Sequence: GSKMTYQGYKELLVEQQGKLLVAKFNNPKKKNCINRVAYQEMTRVLTEVNDDEGVTIVVFTGVGDIFTSGNDLSQSSNTDDIDAFFKQSNATFKAMVLSFVNCRKIVLALVNGPAIGIGATIVGLCDVAWCSETTYFYTPFTKLGLVPEGGSSYMLPLILGRSKASEILLLSEPLSAQEAYQFNFVSRIFKASELESVIWPKLRQYSELPTNSLLQGKRLVKDGFLENLIKANEAECKQLLQQFQHPEFAQAIIDFASRKNKAKL
InterPro domains: - IPR029045: ClpP/crotonase-like domain superfamily (homologous_superfamily) [9-252]
- IPR014748: Enoyl-CoA hydratase, C-terminal (homologous_superfamily) [208-259]
- IPR051053: Enoyl-CoA hydratase/isomerase and chromodomain-containing protein (family) [7-262]
- IPR001753: Enoyl-CoA hydratase/isomerase (family) [16-260]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0016863 (intramolecular oxidoreductase activity, transposing C=C bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: Chemokine-like protein TAFA-5 (Q91WE9)
Organism: Mus musculus (Mouse)
Function: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries.
Subcellular location: Secreted {ECO:0000269|PubMed:29453251}.
Sequence: MAPSPRTSSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
InterPro domains: - IPR020350: Chemokine-like protein TAFA (family) [42-131]
- IPR040329: Chemokine-like protein TAFA-5 (family) [5-131]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0048662 (negative regulation of smooth muscle cell proliferation), GO:1904706 (negative regulation of vascular associated smooth muscle cell proliferation), GO:1904705 (regulation of vascular associated smooth muscle cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)