Protein: H-2 class I histocompatibility antigen, alpha chain (Clone PAG64) (P01895)
Organism: Mus musculus (Mouse)
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: RYEPRARWIEQEGPEYWERETRRAKGNEQSFRVDLRTALRYYNQSAGGSHTLQWMAGCDVESDGRLLRGYWQFAYDGCDYIALNEDLKTWTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGTFQKWASVVVPLGKEQKYTCHVEHEGLPEPLTLRWGKEEPPSSTKTNTVIIAVPVVLGAVVILGAVMAFVMKRRRNTGGKGGDYALAPVSQSSDMSLPDCKV
InterPro domains: - IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [1-138]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [141-232]
- IPR050208: Antigen-presenting and immune regulatory MHC class I-related (family) [1-270]
- IPR010579: MHC class I, alpha chain, C-terminal (domain) [273-297]
- IPR011161: MHC class I-like antigen recognition-like (domain) [1-136]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [139-240]
- IPR007110: Immunoglobulin-like domain (domain) [142-230]
- IPR037055: MHC class I-like antigen recognition-like superfamily (homologous_superfamily) [1-138]
- IPR001039: MHC class I alpha chain, alpha1 alpha2 domains (domain) [16-132]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [214-220]
- IPR003597: Immunoglobulin C1-set (domain) [153-226]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0001906 (cell killing), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0019882 (antigen processing and presentation), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0031341 (regulation of cell killing), GO:0019883 (antigen processing and presentation of endogenous antigen), GO:0002250 (adaptive immune response), GO:0050776 (regulation of immune response), GO:0051129 (negative regulation of cellular component organization), GO:0002697 (regulation of immune effector process), GO:0031343 (positive regulation of cell killing), GO:0050778 (positive regulation of immune response), GO:0002443 (leukocyte mediated immunity), GO:0002699 (positive regulation of immune effector process), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0051128 (regulation of cellular component organization), GO:0001909 (leukocyte mediated cytotoxicity), GO:0002449 (lymphocyte mediated immunity), GO:0002819 (regulation of adaptive immune response), GO:0031344 (regulation of cell projection organization), GO:0002703 (regulation of leukocyte mediated immunity), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002483 (antigen processing and presentation of endogenous peptide antigen), GO:0002821 (positive regulation of adaptive immune response), GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0031345 (negative regulation of cell projection organization), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0001913 (T cell mediated cytotoxicity), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0010977 (negative regulation of neuron projection development), GO:0001914 (regulation of T cell mediated cytotoxicity), GO:0001916 (positive regulation of T cell mediated cytotoxicity), GO:0002456 (T cell mediated immunity), GO:0002711 (positive regulation of T cell mediated immunity), GO:0002709 (regulation of T cell mediated immunity), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0098576 (lumenal side of membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0009897 (external side of plasma membrane), GO:0005783 (endoplasmic reticulum), GO:0098857 (membrane microdomain), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0098553 (lumenal side of endoplasmic reticulum membrane), GO:0005789 (endoplasmic reticulum membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0030666 (endocytic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle), GO:0030670 (phagocytic vesicle membrane)