Protein: P2Y purinoceptor 1 (P2Y1) (ADP receptor) (Purinergic receptor) (P49650)
Organism: Mus musculus (Mouse)
Function: Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P47900}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47900}.
Sequence: MTEVPWSVVPNGTDAAFLAGLGSLWGNSTVASTAAVSSSFQCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGTRKNKTVTCYDTTSNDYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVKALIYNDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
InterPro domains: - IPR000142: P2Y purinoceptor 1 (family) [2-372]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [68-324]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [53-332]
Interaction partners: - Guanine nucleotide-binding protein G
- P2X purinoceptor 1
- P2X purinoceptor 7
- Prothrombin
- P2X purinoceptor 4
- P2X purinoceptor 2
- Adenosine receptor A2a
- P2X purinoceptor 3
- P2X purinoceptor
- Adenosine receptor A1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0097110 (scaffold protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0046983 (protein dimerization activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0043531 (ADP binding), GO:0046982 (protein heterodimerization activity), GO:0004930 (G protein-coupled receptor activity), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0001664 (G protein-coupled receptor binding), GO:0016502 (nucleotide receptor activity), GO:0005524 (ATP binding), GO:0001614 (purinergic nucleotide receptor activity), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0051047 (positive regulation of secretion), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0003014 (renal system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0050803 (regulation of synapse structure or activity), GO:0051668 (localization within membrane), GO:0044089 (positive regulation of cellular component biogenesis), GO:0003013 (circulatory system process), GO:0043114 (regulation of vascular permeability), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046887 (positive regulation of hormone secretion), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0046883 (regulation of hormone secretion), GO:0003012 (muscle system process), GO:2000026 (regulation of multicellular organismal development), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009612 (response to mechanical stimulus), GO:1903532 (positive regulation of secretion by cell), GO:0046683 (response to organophosphorus), GO:0030030 (cell projection organization), GO:0046928 (regulation of neurotransmitter secretion), GO:0050807 (regulation of synapse organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0051246 (regulation of protein metabolic process), GO:0032990 (cell part morphogenesis), GO:0070201 (regulation of establishment of protein localization), GO:0050769 (positive regulation of neurogenesis), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0019932 (second-messenger-mediated signaling), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0031667 (response to nutrient levels), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0048858 (cell projection morphogenesis), GO:1901701 (cellular response to oxygen-containing compound), GO:0071417 (cellular response to organonitrogen compound), GO:0003018 (vascular process in circulatory system), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0031344 (regulation of cell projection organization), GO:0050433 (regulation of catecholamine secretion), GO:0071310 (cellular response to organic substance), GO:0055001 (muscle cell development), GO:1901888 (regulation of cell junction assembly), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:1901699 (cellular response to nitrogen compound), GO:0051960 (regulation of nervous system development), GO:0035150 (regulation of tube size), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0010243 (response to organonitrogen compound), GO:0048514 (blood vessel morphogenesis), GO:0051965 (positive regulation of synapse assembly), GO:0031346 (positive regulation of cell projection organization), GO:0008347 (glial cell migration), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051046 (regulation of secretion), GO:0008104 (protein localization), GO:0043269 (regulation of monoatomic ion transport), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0072657 (protein localization to membrane), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:1990778 (protein localization to cell periphery), GO:0090497 (mesenchymal cell migration), GO:0019722 (calcium-mediated signaling), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0097746 (blood vessel diameter maintenance), GO:0035296 (regulation of tube diameter), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0048699 (generation of neurons), GO:0050767 (regulation of neurogenesis), GO:0031401 (positive regulation of protein modification process), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043408 (regulation of MAPK cascade), GO:0033365 (protein localization to organelle), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0019220 (regulation of phosphate metabolic process), GO:0042063 (gliogenesis), GO:0031175 (neuron projection development), GO:0072659 (protein localization to plasma membrane), GO:1903305 (regulation of regulated secretory pathway), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0006940 (regulation of smooth muscle contraction), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0015909 (long-chain fatty acid transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0045177 (apical part of cell), GO:0098794 (postsynapse), GO:0048786 (presynaptic active zone), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0016324 (apical plasma membrane), GO:0045211 (postsynaptic membrane), GO:0042734 (presynaptic membrane), GO:0048787 (presynaptic active zone membrane), GO:0009925 (basal plasma membrane), GO:0005739 (mitochondrion), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0016323 (basolateral plasma membrane), GO:0032279 (asymmetric synapse)