Protein: 26S proteasome regulatory subunit rpn501 (P0CU17)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for proper proteasome assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:12783882}.
Sequence: MEQKPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFKKHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYGSFDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAVVQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSNPVFAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLEKVRQLIIKEEMMNSIQQAVAK
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [325-407]
- IPR040896: 26S proteasome regulatory subunit RPN5, C-terminal domain (domain) [407-436]
- IPR040134: 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 (family) [4-434]
- IPR054559: PSMD12/CSN4-like, N-terminal (domain) [32-247]
- IPR000717: Proteasome component (PCI) domain (domain) [230-417]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [327-406]
Interaction partners: - Probable 26S proteasome subunit rpt4
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit rpn7
- 26S proteasome regulatory subunit 4 homolog
- Probable 26S proteasome regulatory subunit rpn3
- Probable 26S proteasome regulatory subunit rpn9
- Probable 26S proteasome regulatory subunit rpn6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0022624 (proteasome accessory complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0008541 (proteasome regulatory particle, lid subcomplex), GO:1902494 (catalytic complex), GO:0005838 (proteasome regulatory particle), GO:0034399 (nuclear periphery), GO:0031974 (membrane-enclosed lumen), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:0043233 (organelle lumen), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:1905369 (endopeptidase complex), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)