Protein: RNA-binding protein FXR2 (Q9WVR4)
Organism: Mus musculus (Mouse)
Function: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis. Specifically binds to AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs- containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm. Postsynapse. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Localization to the post-synaptic region is dependent on FMR1
Sequence: MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWCLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNSSSLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRDLVGKVTGKTGKVIQGIVDKSGVVRVRVEGDNDKKNPKEGGMVPFIFVGTRENISNAQALLEYHLSYLQEVETLRLERLQIDEQLRQIGAGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRGRRTGGPAYGPSSDPSTASETESEKREESNRAGPGDRDPPSRGEESRRRRLGPGKGPPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGALESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPLGRTEPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSLVNGVS
InterPro domains: - IPR004087: K Homology domain (domain) [227-366]
- IPR040472: Synaptic functional regulator FMRP, KH0 domain (domain) [133-217]
- IPR040148: Fragile X messenger ribonucleoprotein 1 (family) [14-673]
- IPR047420: RNA-binding protein FXR2, second Tudor-like Agenet domain (domain) [69-136]
- IPR008395: Agenet-like domain (domain) [72-126]
- IPR047421: RNA-binding protein FXR2, first Tudor-like Agenet domain (domain) [13-67]
- IPR022034: Fragile X messenger ribonucleoprotein 1-like, C-terminal core (domain) [364-492]
- IPR047424: RNA-binding protein FXR2, second type I K homology domain (domain) [228-290]
- IPR041560: FMR1, tudor domain (domain) [14-125]
- IPR004088: K Homology domain, type 1 (domain) [231-362]
- IPR047422: RNA-binding protein FXR2, first type I K homology domain (domain) [133-209]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [226-369]
- IPR032172: Fragile X-related protein 1, C-terminal region 1 (domain) [504-578]
Interaction partners: - Cytoplasmic FMR1-interacting protein 2
- Cytoplasmic FMR1-interacting protein 1
- RNA-binding protein FXR1
- Fragile X messenger ribonucleoprotein 1
- Protein argonaute-2
- Poly(U)-binding-splicing factor PUF60
- Cytoplasmic polyadenylation element-binding protein 1
- Transcriptional activator protein Pur-alpha
- FMR1-interacting protein NUFIP1
- Heterogeneous nuclear ribonucleoprotein K
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0061061 (muscle structure development), GO:0048513 (animal organ development), GO:0007517 (muscle organ development), GO:0060538 (skeletal muscle organ development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0097447 (dendritic tree), GO:0005844 (polysome), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite)