Protein: Cu(2+)-transporting P-type ATPase (Q5AG51)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Endomembrane system; Multi-pass membrane protein. Membrane
Sequence: MKSSAILESNPNQNNNVTVVLEVLDLHTAKDITDVINILDELFPKLKSKDFDHQELTLIYDSNDYDDMSILNAISEIGFPVKILSSTAPQCKTTVNIQGMTCGACSASITEALEKTPGVYKASISLVTENGLIMHSPKLSPENIITIIEDCGFDAQIESSKTKQSSAPESSQDQSKRLNTTIGIIGMTCGACSASITNVLEKLPGVENVSVSLITEEASIVHDSTITTVQQLKEAIEDCGFTPTFNKSINLNQYQNTNDSNEEVTLKIVGVNHTTDLIGLRYNIEAYLRSISGVQKFELTLRGMNASSNIMPTQVGTLITEEDTIADVKSLVNELVFQYDSDSVGIRDIIDGLNTISDNIEFMVINSLDQSSATQLKLLSKVKDINYWKKIFIQSLLFGIPVLFLNHTKNWPIWKTTMIFPGLYLVSLLELILSTYIQFYLGSVFIKKFSSFLRKKFKGATMDVLVCISTMCSYIFSLTTIIVSVWNGQKNGPPPVLFDTLVMLISFVSFGKLLENKAKGATSTALSSLLSLTPSTCTIINDIPGYQKFIEDQQSLEKSEKSNSLSMQEFPTRVISIDLVQPNDIAIVLPGGKVPADGEIVFGETEIDESLITGEPLPVYKKLKDKVIGGSINGPHLIHIKVTHTGKKSQLQQIINLVKESQVNKAPVQKFSDYIAARFVPFVLLLAIFTFILWMIICFTIHQDKLPKIFQNETNGKFFVCLKLSISVIVVACPCALGLAAPTAVMVGTGVGAINGVLIKGAKVLEKITGVNIILFDKTGTLTTGEMSLVNFQPIMSKSSITISDWWKLVGSVECHSEHPIGRALTKSAKTNLNLNFDDDHFDTTVNDINVLIGLGIQANVTLANNPQTQFNVYVGNDKLIESKFPNLLNNIDEKLLHSANTVSHVIIDGEYSGYIELTDALKSGSWEVVNYLKTQGYIVGMVTGDNRGAALKIAQEVGIPFDNVFYEVSPIHKDNVITDLHNRLGGNQSSSVNVAFIGDGINDAPALAKADIGMAISSGTDIAIESADIVLIGGRSNQTDLHGVVNALQISTATFNRIKINFLWAIIYNIFMLPFAMGCFLPLNIVLPPVAAGAAMMFSSLSVVFSSLLLKRWTPPKIETKKTFIDDLEMGNNATGGDGDGFSLKNGTIEEFNNVKRKSAVNFSSLFAKMTTTRRNRRGGGGGGGRSNGNNNQSYELVSNRFS
InterPro domains: - IPR023214: HAD superfamily (homologous_superfamily) [766-1052]
- IPR017969: Heavy-metal-associated, conserved site (conserved_site) [97-213]
- IPR006121: Heavy metal-associated domain, HMA (domain) [91-244]
- IPR036412: HAD-like superfamily (homologous_superfamily) [773-1108]
- IPR036163: Heavy metal-associated domain superfamily (homologous_superfamily) [88-245]
- IPR027256: P-type ATPase, subfamily IB (family) [462-1111]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [757-1033]
- IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [573-658]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [786-922]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [777-783]
- IPR001757: P-type ATPase (family) [552-1082]
- IPR059000: P-type ATPase, A domain (domain) [572-659]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [472-1087]
Interaction partners: - Copper metallochaperone
- Superoxide dismutase 1 copper chaperone
- High-affinity iron permease
- Copper transport protein
- Copper metallochaperone
- Ferroxidase
- RRN6 beta-propeller domain-containing protein
- Ferric/cupric reductase transmembrane component 1
- Siderophore transporter
- Fth1p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005375 (copper ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0043473 (pigmentation), GO:0043474 (pigment metabolic process involved in pigmentation), GO:0048066 (developmental pigmentation), GO:0042440 (pigment metabolic process), GO:0043324 (pigment metabolic process involved in developmental pigmentation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)