Protein: MAP kinase kinase MKK2/SSP33 (EC 2.7.12.2) (P32491)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Serine/threonine protein kinase involved in a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involves the kinase PKC1 that may act on the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the MPK1 kinase.
Sequence: MASMFRPPESNRSHQKTPKLTLPVNLVQNAKSTNDGQHLNRSPYSSVNESPYSNNSTSATSTTSSMASNSTLLYNRSSTTTIKNRPVPPPLPPLVLTQKKDGIEYRVAGDSQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLSAYDFSSSGSNSAPLSANNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVKKCWEKEKDGI
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [210-487]
- IPR017441: Protein kinase, ATP binding site (binding_site) [220-243]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [338-350]
- IPR000719: Protein kinase domain (domain) [214-481]
Interaction partners: - Serine/threonine-protein kinase BCK1/SLK1/SSP31
- Mitogen-activated protein kinase SLT2/MPK1
- MAP kinase kinase MKK1/SSP32
- Serine/threonine-protein kinase KDX1
- Protein SPA2
- GTP-binding protein RHO1
- Serine/threonine-protein kinase STE11
- Transcription factor RLM1
- Protein SLG1
- RHO1 GDP-GTP exchange protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0019953 (sexual reproduction), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0016049 (cell growth), GO:0042221 (response to chemical), GO:0032505 (reproduction of a single-celled organism), GO:0071554 (cell wall organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0104004 (cellular response to environmental stimulus), GO:0035556 (intracellular signal transduction), GO:0000747 (conjugation with cellular fusion), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0016043 (cellular component organization), GO:0071555 (cell wall organization), GO:0031505 (fungal-type cell wall organization), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:0000165 (MAPK cascade), GO:0007231 (osmosensory signaling pathway), GO:0006796 (phosphate-containing compound metabolic process), GO:0045229 (external encapsulating structure organization), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0006972 (hyperosmotic response), GO:0016310 (phosphorylation), GO:0051403 (stress-activated MAPK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0060187 (cell pole), GO:0043332 (mating projection tip), GO:0005935 (cellular bud neck), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0005934 (cellular bud tip), GO:0005937 (mating projection)