Protein: Glutathione transferase omega-1 (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (P34345)
Organism: Caenorhabditis elegans
Function: Exhibits glutathione-dependent thiol transferase activity (By similarity). Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid (By similarity). Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity). Protects against environmental stress and oxidative stress.
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MVLTGVTSKAIRKGDAEPPLSKGSFRVYNMRFCPWAERAMLYVAAKGIEAEVVNLNVTDKLEWYWTKHYQGKAPAVEHNGKVVIESGFIPEYLDDAFPETRILPTDPYEKVQQKLLADRLTAVAHAVPLLFAVMRDRTLKDEKQRKVFEVLKQAENLLANDFYAGSQPGYPDYLSFPFFEKIWWSASLDGVVDLPTIEFPGEEEYPKLTKWFQKMISSDVVQSVTQSLEHGAAFMNAYATHQELNYDLGL
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [12-100]
- IPR050983: Glutathione S-transferase Omega/HSP26 (family) [6-247]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [103-240]
- IPR005442: Glutathione S-transferase, omega-class (family) [23-181]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [122-218]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [106-234]
- IPR040079: Glutathione transferase family (family) [26-217]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [21-101]
Interaction partners: - Glutathione S-transferase kappa 1
- glutathione-specific gamma-glutamylcyclotransferase
- Glutathione S-transferase P 10
- Glutathione S-transferase P
- Glutathione reductase, mitochondrial
- Probable glutathione S-transferase 6
- Glutathione peroxidase 3
- Probable glutathione S-transferase 8
- Probable glutathione S-transferase 5
- Glutathione synthetase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0004364 (glutathione transferase activity), GO:0042803 (protein homodimerization activity), GO:0015036 (disulfide oxidoreductase activity), GO:0016672 (oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor), GO:0015038 (glutathione disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:1901700 (response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)