Protein: Ubiquitin-like protein atg12 (Q86CR6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ubiquitin-like protein involved in autophagy vesicles formation. Required for atg8 association to the vesicle membranes. Conjugated to atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme is essential for its function (By similarity)
Subcellular location: Cytoplasm
Sequence: MEEEEKNNNEVASPTEQNTESTTEQQPQLPVKITSESKIIVYFKNAGGAQPLKQKKFKIQANVSFQNVIDKLRGQLKLKSNESLFLFINQVFQPSPDEILGELYKCFSHNDQLIINYSLQMAWG
InterPro domains: - IPR007242: Ubiquitin-like protein Atg12 (family) [31-124]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [16-124]
Interaction partners: - Autophagy protein 5
- Ubiquitin-like modifier-activating enzyme atg7
- Autophagy-related protein 3
- Protein tipD
- Ubiquitin-like-conjugating enzyme ATG10
- Autophagy-related protein 18
- Autophagy-related protein 8
- Serine/threonine-protein kinase atg1
- Probable serine/threonine-protein kinase vps15
- Autophagy-related protein 9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0099120 (socially cooperative development), GO:0071840 (cellular component organization or biogenesis), GO:0061919 (process utilizing autophagic mechanism), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006914 (autophagy), GO:0043207 (response to external biotic stimulus), GO:0044248 (cellular catabolic process), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0030587 (sorocarp development), GO:0016236 (macroautophagy), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0016192 (vesicle-mediated transport), GO:0043933 (protein-containing complex organization), GO:0022411 (cellular component disassembly), GO:0097352 (autophagosome maturation), GO:0006909 (phagocytosis), GO:0006897 (endocytosis), GO:0032984 (protein-containing complex disassembly), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0006907 (pinocytosis), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0000407 (phagophore assembly site)