Protein: Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-) (A0A8I6GM68)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UBN7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UBN7}. Nucleus {ECO:0000250|UniProtKB:Q9UBN7}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9UBN7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9UBN7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9UBN7}. Note=Mainly cytoplasmic where it is associated with microtubules (By similarity). Can shuttle between the cytoplasm and the nucleus. Found exclusively in the cytoplasm in proliferative cells with a fraction found in the nucleus during differentiation (By similarity). May translocate to the nucleus following DNA damage (By similarity). {ECO:0000250|UniProtKB:Q9UBN7, ECO:0000250|UniProtKB:Q9Z2V5}.
Sequence: MTSTGQDSSTRQRKSRHNPQSPLQDSSATLKRGGKKGAVPHSSPNLAEVKKKGKMKKLSQPAEEDLIVGLQGLDLNSETRVPVGTGLVFDEQLNDFHCLWDDSFPENPERLHAIKEQLILEGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAGTYDSVYLHPNSYSCACLATGSVLRLVDAVMGAEIRNGMAVIRPPGHHAQRSLMDGYCMFNHLAVAARYAQKKHRIQRILIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVSFCSHKLSLACFPRGSREMTDYYIAFLCLQVGMRDADYIAAFLHILLPVAFEFQPQLVLVAAGFDALHGDPKGEMSATPAGFAHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGDPCPMLESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLEDEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRDLHREGANFESIYICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQVIAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFTVNVPWNGPRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSLRPPQSGALASISEVIQVHRKYWRSLRLMKMEDKEERSSSRLVIKKLPQSASPVSAKGMTTPKGKVLEAGMRKPTAALPTKESTLGQAKAKTAKALLAQGQSSEQAAKGTTLDLATSKDTVGGATTDQCASVAATENSANQTTSGEEASGETESFGTSPSSNASKQTTGASPLHGAAAQQSPELGLSSTLELSSEAQEVQESEEGLLGEAAGGQDMNSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGSVQENWVCLTCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYLCQAYVHHEDLQDVKNAAHQNKFGEGMPHLQ
InterPro domains: - IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [79-882]
- IPR000286: Histone deacetylase HDAC (family) [637-772]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [83-864]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1075-1181]
- IPR001607: Zinc finger, UBP-type (domain) [1079-1177]
- IPR023801: Histone deacetylase domain (domain) [105-827]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0019213 (deacetylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051640 (organelle localization), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0007017 (microtubule-based process), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0051129 (negative regulation of cellular component organization), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0060255 (regulation of macromolecule metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0032101 (regulation of response to external stimulus), GO:0032886 (regulation of microtubule-based process), GO:0009725 (response to hormone), GO:0046907 (intracellular transport), GO:0050806 (positive regulation of synaptic transmission), GO:0051656 (establishment of organelle localization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050773 (regulation of dendrite development), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006979 (response to oxidative stress), GO:0051646 (mitochondrion localization), GO:0050920 (regulation of chemotaxis), GO:0001558 (regulation of cell growth), GO:0080135 (regulation of cellular response to stress), GO:0051649 (establishment of localization in cell), GO:1901700 (response to oxygen-containing compound), GO:0051130 (positive regulation of cellular component organization), GO:0010033 (response to organic substance), GO:0007018 (microtubule-based movement), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0050922 (negative regulation of chemotaxis), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0033554 (cellular response to stress), GO:0048640 (negative regulation of developmental growth), GO:0006810 (transport), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0035902 (response to immobilization stress), GO:0032102 (negative regulation of response to external stimulus), GO:0034599 (cellular response to oxidative stress), GO:0032535 (regulation of cellular component size), GO:0097305 (response to alcohol), GO:1901654 (response to ketone), GO:0051246 (regulation of protein metabolic process), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:1903209 (positive regulation of oxidative stress-induced cell death), GO:0051968 (positive regulation of synaptic transmission, glutamatergic), GO:0048545 (response to steroid hormone), GO:0050769 (positive regulation of neurogenesis), GO:0050678 (regulation of epithelial cell proliferation), GO:0099111 (microtubule-based transport), GO:1900407 (regulation of cellular response to oxidative stress), GO:0061387 (regulation of extent of cell growth), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0050768 (negative regulation of neurogenesis), GO:1903201 (regulation of oxidative stress-induced cell death), GO:0007399 (nervous system development), GO:1902882 (regulation of response to oxidative stress), GO:0030517 (negative regulation of axon extension), GO:0048843 (negative regulation of axon extension involved in axon guidance), GO:1901216 (positive regulation of neuron death), GO:0022604 (regulation of cell morphogenesis), GO:0010970 (transport along microtubule), GO:0051654 (establishment of mitochondrion localization), GO:0031344 (regulation of cell projection organization), GO:0071310 (cellular response to organic substance), GO:0062197 (cellular response to chemical stress), GO:0060284 (regulation of cell development), GO:0051248 (negative regulation of protein metabolic process), GO:0010720 (positive regulation of cell development), GO:0050804 (modulation of chemical synaptic transmission), GO:1901214 (regulation of neuron death), GO:0048814 (regulation of dendrite morphogenesis), GO:0051960 (regulation of nervous system development), GO:0071107 (response to parathyroid hormone), GO:0072384 (organelle transport along microtubule), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0031346 (positive regulation of cell projection organization), GO:0033993 (response to lipid), GO:0030516 (regulation of axon extension), GO:0051247 (positive regulation of protein metabolic process), GO:0033043 (regulation of organelle organization), GO:0014070 (response to organic cyclic compound), GO:0034643 (establishment of mitochondrion localization, microtubule-mediated), GO:0031345 (negative regulation of cell projection organization), GO:0010721 (negative regulation of cell development), GO:0030182 (neuron differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0051493 (regulation of cytoskeleton organization), GO:0071548 (response to dexamethasone), GO:0010821 (regulation of mitochondrion organization), GO:0031960 (response to corticosteroid), GO:0031400 (negative regulation of protein modification process), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0071374 (cellular response to parathyroid hormone stimulus), GO:0031401 (positive regulation of protein modification process), GO:0010770 (positive regulation of cell morphogenesis involved in differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:1903203 (regulation of oxidative stress-induced neuron death), GO:0008088 (axo-dendritic transport), GO:0014075 (response to amine), GO:0008361 (regulation of cell size), GO:0019220 (regulation of phosphate metabolic process), GO:0010769 (regulation of cell morphogenesis involved in differentiation), GO:0050771 (negative regulation of axonogenesis), GO:0047497 (mitochondrion transport along microtubule), GO:0051966 (regulation of synaptic transmission, glutamatergic), GO:0050775 (positive regulation of dendrite morphogenesis), GO:0051412 (response to corticosterone), GO:0048841 (regulation of axon extension involved in axon guidance), GO:0098930 (axonal transport), GO:0019896 (axonal transport of mitochondrion), GO:0001932 (regulation of protein phosphorylation), GO:0051385 (response to mineralocorticoid), GO:0051384 (response to glucocorticoid), GO:1901984 (negative regulation of protein acetylation), GO:0090311 (regulation of protein deacetylation), GO:0001975 (response to amphetamine), GO:0010975 (regulation of neuron projection development), GO:0042325 (regulation of phosphorylation), GO:0090312 (positive regulation of protein deacetylation), GO:1901983 (regulation of protein acetylation), GO:0090043 (regulation of tubulin deacetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043005 (neuron projection), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0015630 (microtubule cytoskeleton)