Protein: G protein alpha s subunit (Adenylate cyclase-stimulating G alpha protein) (Guanine nucleotide-binding protein G(s) subunit alpha) (P20354)
Organism: Drosophila melanogaster (Fruit fly)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase (By similarity).
Sequence: MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL
InterPro domains: - IPR011025: G protein alpha subunit, helical insertion (homologous_superfamily) [75-191]
- IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit (family) [14-385]
- IPR000367: G-protein alpha subunit, group S (family) [74-353]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [40-383]
Interaction partners: - G protein beta subunit 5
- Guanine nucleotide-binding protein subunit beta-1
- Guanine nucleotide-binding protein subunit beta-2
- Guanine nucleotide-binding protein subunit gamma-e
- Guanine nucleotide-binding protein subunit gamma-1
- G protein alpha o subunit subunit alpha 47A)
- Adenylate cyclase type 9
- Dopamine receptor 1
- 5-hydroxytryptamine
- Uncharacterized protein, isoform B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0007210 (serotonin receptor signaling pathway), GO:0010033 (response to organic substance), GO:0098542 (defense response to other organism), GO:0071417 (cellular response to organonitrogen compound), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0042742 (defense response to bacterium), GO:1901699 (cellular response to nitrogen compound), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0071869 (response to catecholamine), GO:0071870 (cellular response to catecholamine stimulus), GO:1903350 (response to dopamine), GO:0050829 (defense response to Gram-negative bacterium), GO:0071868 (cellular response to monoamine stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0071867 (response to monoamine), GO:1903351 (cellular response to dopamine)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)