Protein: Neuronal pentraxin-1 (NP1) (Neuronal pentraxin I) (NP-I) (Q62443)
Organism: Mus musculus (Mouse)
Function: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
Subcellular location: Secreted {ECO:0000250|UniProtKB:Q15818}. Cytoplasmic vesicle, secretory vesicle {ECO:0000305}. Endoplasmic reticulum {ECO:0000305}.
Sequence: MLAGRAARTCALLALCLLGSGAQDFGPTRFICTSVPVDADMCAASVAAGGAEELRSNVLQLRETVLQQKETILSQKETIRELTTKLGRCESQSTLDSGPGEARSGGGRKQPGSGKNTMGDLSRTPAAETLSQLGQTLQSLKTRLENLEQYSRLNSSSQTNSLKDLLQSKIDDLERQVLSRVNTLEEGKGGPKNDTEERAKIESALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMYAKVKKSLPEMYAFTVCMWLKSSAAPGVGTPFSYAVPGQANELVLIEWGNNPMEILINDKVAKLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGNGENLAPYHPIKPQGVLVLGQEQDTLGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSSKALSGNVIAWAESQIEIFGGATKWTFEACRQIN
InterPro domains: - IPR030476: Pentaxin, conserved site (conserved_site) [314-321]
- IPR001759: Pentraxin-related (family) [222-428]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [229-422]
- IPR051360: Neuronal Pentraxin and Related (family) [85-429]
Interaction partners: - Glutamate receptor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0045202 (synapse), GO:0043083 (synaptic cleft), GO:0098978 (glutamatergic synapse)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0007267 (cell-cell signaling), GO:0023051 (regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0065009 (regulation of molecular function), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0050794 (regulation of cellular process), GO:0099536 (synaptic signaling), GO:0099177 (regulation of trans-synaptic signaling), GO:0010469 (regulation of signaling receptor activity), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0050804 (modulation of chemical synaptic transmission), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0099601 (regulation of neurotransmitter receptor activity), GO:0031644 (regulation of nervous system process), GO:0099537 (trans-synaptic signaling), GO:0098962 (regulation of postsynaptic neurotransmitter receptor activity), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0005739 (mitochondrion), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043083 (synaptic cleft), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0098978 (glutamatergic synapse)