wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Dickkopf WNT-signaling pathway inhibitor 3b (A2CEU2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MLKSMILCLCVGLAVGSSVHRGAHLDISDTLEEHVAHGQTTLNEMFREVEKLMEDTQHKLEEAVHQMENETTNSLLNGRDFPDNFHDETTTEIKLGNRTIQLIERINKKTDNKTGKTHFSRTLIQNTERWNEVDHECMIDEDCGDGSFCLYEIVTSKCVPCQTTNMECTKDVECCGDQLCVWGVCAQNKTKGQSGTICQNQNDCSPQHCCAFHKALLFPVCRPKPQEGQGCEREGNQLMEVLLWEDEGPREHCPCAAGLLCQQIQKSSVCVDERHASGEGNED
InterPro domains: - IPR047300: Dickkopf-related protein 3, second cysteine-rich domain (domain) [188-271]
- IPR006796: Dickkopf, N-terminal cysteine-rich (domain) [136-186]
- IPR047301: Dickkopf-related protein 3, N-terminal domain (domain) [36-186]
- IPR039863: Dickkopf related protein 1-4 (family) [28-270]
Interaction partners: - Secreted frizzled-related protein 1
- Wnt inhibitory factor 1
- Kringle-containing protein marking the eye and the nose
- Secreted frizzled-related protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0021536 (diencephalon development), GO:0060322 (head development), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protransforming growth factor alpha precursor (Q7T011)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space
Sequence: MMYRAFWDTIFLLTGSLFTYGQVQENSTSTTTIATTTTTTTTTTTTTTTSTTTTTTTTRVRKFIAAAVHSHFDDCPDSHSHFCFHGTCRFLILEETPACVCHPGFVGMRCEHADLLAVVASNHRQQTVATMLVFCWWRRGGCGRGHTLSCWTEKPRSILTSGTSCCNSETGIPVLHFHFYTIFMLSCTVVC
InterPro domains: - IPR000742: EGF-like domain (domain) [71-111]
Interaction partners: - Insulin-degrading enzyme
- Mast/stem cell growth factor receptor
- Fibroblast growth factor receptor 2
- Platelet-derived growth factor receptor alpha
- Fibroblast growth factor receptor 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016477 (cell migration), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0001667 (ameboidal-type cell migration), GO:0014033 (neural crest cell differentiation), GO:0014032 (neural crest cell development), GO:0090497 (mesenchymal cell migration), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: E2F transcription factor 4, p107/p130-binding (Q6TH18)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MAESNSASFPHSTPNGSSRHEKSLGLLTVKFVTLLQEAKDGVLDLKVAADSLAVKQKRRIYDITNVLEGIGLIEKKTKNTIQWKGESTGCQPQEVLEQVELLKANIADLELQERELDMQKACLQQSIKQLNEDPYSCRYPYCQ
InterPro domains: - IPR003316: E2F/DP family, winged-helix DNA-binding domain (domain) [19-85]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [13-87]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [19-83]
- IPR037241: E2F-DP heterodimerization region (homologous_superfamily) [97-142]
- IPR015633: E2F Family (family) [12-133]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0009790 (embryo development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0030097 (hemopoiesis), GO:0048568 (embryonic organ development), GO:0035162 (embryonic hemopoiesis), GO:0060215 (primitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: E2F transcription factor 5 (A5WUE8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MAESNSASFPHSTPNGSSRHEKSLGLLTVKFVTLLQEAKDGVLDLKVAADSLAVKQKRRIYDITNVLEGIGLIEKKTKNTIQWKGESTGCQPQEVLEQVELLKANIADLELQERELDMQKACLQQSIKQLNEDPYSCRYSYVMHEDICDAFSGDTLLAVMAPSGTQLEVPVPEMGHNGQKKYQVNLRSHSAPIQVMLINRETSCSKPVVVSVPPIDDISSMPTPPSTPAGLQRFPISSIDLCDQKHGLLKSPAAEHQLTPSSTSPDVHMECNPESPASQCLLMQSSLGGPEEQQRELGGQDLQSMLEEMRDEREGVSNLIDELMSSDVFPLLRLSPNPGVDYSFNLDDNEGVCDLFDVQILNY
InterPro domains: - IPR003316: E2F/DP family, winged-helix DNA-binding domain (domain) [19-85]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [13-87]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [19-83]
- IPR037241: E2F-DP heterodimerization region (homologous_superfamily) [97-200]
- IPR032198: E2F transcription factor, CC-MB domain (domain) [97-201]
- IPR015633: E2F Family (family) [12-356]
Interaction partners: - Retinoblastoma-like protein 2
- E2F transcription factor 4
- Transcription factor
- Multicilin
- Protein lin-9 homolog
- Protein lin-54 homolog
- BAG family molecular chaperone regulator 4
- Protein lin-52 homolog
- Formin-like 2a
- Cyclin-A1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0048762 (mesenchymal cell differentiation), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0060485 (mesenchyme development), GO:0014033 (neural crest cell differentiation), GO:0014032 (neural crest cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Low molecular weight phosphotyrosine protein phosphatase (A0A8M1P258)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates
Subcellular location: Cytoplasm
Sequence: MAASSGKSVLFVCLGNICRSPIAEAVFRKMATDSGVVDKWRIDSAATSTYEIGNPPDHRGQACMKKHGVSMRHVARQVTKDDFMSFDYILCMDESNLRDLNKKASSVKNSKAKIELLGSYDPEKQLIIQDPYYGSDKDFETVYEQCARCCKAFLEQHS
InterPro domains: - IPR050438: Low Molecular Weight Phosphotyrosine Protein Phosphatase (family) [1-156]
- IPR023485: Phosphotyrosine protein phosphatase I (domain) [7-156]
- IPR002115: Protein-tyrosine phosphatase, low molecular weight, mammalian (family) [28-156]
- IPR036196: Phosphotyrosine protein phosphatase I superfamily (homologous_superfamily) [7-155]
- IPR017867: Protein-tyrosine phosphatase, low molecular weight (family) [9-143]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0003993 (acid phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0007154 (cell communication), GO:0099536 (synaptic signaling), GO:0099537 (trans-synaptic signaling), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Tetraspanin (A0A8M2BK40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence: MGQGEASARGTSMEGDCLSCIKYLMFIFNFFIFLGGSFLLGVGIWVLVDPTGFREIVAANSLLFTGVYAILIMGGMLFLLGFLGCCGAIRENKCLLLFFFMLILVIFLAELAVAILAFIFREHLTRDYFTKELKTHYQGTNSTDVFTSTWNAIMTTFNCCGVNSAEDFDDQSLFRRLNPSRIVPEVCCQRTDLMMSKEECLRGIMPIRNKGCYSAVVDYFETYIYMAGALAIVVLTIELFAMVFAMCLFRGIQ
InterPro domains: - IPR018503: Tetraspanin, conserved site (conserved_site) [74-96]
- IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [121-223]
- IPR000301: Tetraspanin, animals (family) [15-252]
- IPR018499: Tetraspanin/Peripherin (family) [21-250]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:2000026 (regulation of multicellular organismal development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:1901342 (regulation of vasculature development), GO:0045765 (regulation of angiogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: FinTRIM family, member 67 (A0A0R4IJ94)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MAQAGVFLEHDQFNCSICLDVLKDPVTIPCGHSYCKGCIKNYWDQDDYLGIYGCPQCRQSFAPRPLLGRNTMLADVVEKLKKTGLHAGPASDPTQAEPGDVECDVCSGTKNKAFKSCLVCLASYCETHLQPHYESPAFQKHRLASPSKKMQEQLCSRHDKLLEVFCRTDQQCICYLCLTDEHKGHDTVLATAEMNEKKNALLEMRRVSQRRIEEREKELADLRQATQMLTLSAQTALEESERVFTELVCSVERRRAEVKELIRGQERAAVSQAQTLLQQLEQEITELKKRHAELGELSQTDDHIAFLQNCKSLCAQPVSVELPSITSEPNFTSVIAAVTEFQSLLEDVCQGGFVSISEKVDDVTIIQNTIPKTDLESNTAPVFGQTAQIPFTINVPTISVFPFSSFGSRTQGPRQRLQPRRRRR
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [15-58]
- IPR000315: B-box-type zinc finger (domain) [150-190]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [30-39]
- IPR051051: E3 ubiquitin-protein ligase TRIM/RNF (family) [11-370]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [10-79]
- IPR058030: TRIM8/14/16/25/29/45/65, coiled-coil region (domain) [212-350]
Interaction partners: - ADP-ribosylation factor-like 16
- P2Y purinoceptor 1
- Interferon regulatory factor 2-binding protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Tumor protein D52 (I3IT45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MEENDKGTQRPDFIQEVGEEAVDAAPCSPCTVLTEQEQAELHSELQKVEEEIQTLSQVLAAKEKQVAEIKRKLGITPLNELKQNLSKGWHDVTTSTAYKKTSETLSQVGQKATTAFSSVGTAITRKLEDVRLQSFSNSFGNTPSFKSFEEKVETLKTKMSPKPSTSDIEEVSDSTPDGEPMIKQPDDTFSPDQQPH
InterPro domains: - IPR007327: Tumour protein D52 (family) [11-172]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm)
Protein: Tetratricopeptide repeat protein 7A (A0A8M9QA29)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and HYCC1, via direct interactions
Subcellular location: Cell membrane. Cytoplasm
Sequence: MSSRLSFSQYRLEAEVDRCRSECQWDKIPSLVEQLAAARLHDDDDYRTLLLAEALLEECLLENMTLLKNSTPLTEHSQLKLARAKAQLDSILCRGHLEPHYLNEALLLLAKVHYVQGRYRDAQGMCARAGVDDFTHQDQPVYQLRMLAEAFVIKGLSLDHQSMSGASRVRLSEREEECQTCYLMACDAGLLYLQELDKTVCTPSSKTAKSASSVPHFDLDPGFFLQAALQSAYLSLLRKGHLAQGTHQLRRVLRAVESRGSQSFRKTVARRLAEVLLGSVCEDAYWGPLSPPPPGWLKKEGATHPKDAIYPSSKPPQRYSTEGAFCPKDVVEEAVLVLLITESMASGEAVISRTPEHREARESSMQDASSVYDLLSIGMGRRGQYSMLSECLERAMKFSYNEFHLWYQLGLSLMASGKNEDAVAVLKECAAMRPQDPIPPLLAAKVCINHLHWLEDAVTLSAGVVALGDCAEESLARAHLAIGLCRSLQASDATLKADCDEFNRRALQSLRRAHALDPQDPQISFYLSLQFALVRQLSEAMEPLQLALNVRGDDLHSLHLLALLLSAQKHYQHALDTLKLALNQHPDNFNLLFTKVKLEQVLFGPGAALQTCAEMLQLWQSRYDFTRPSEEDDSNSIPPEPGPLSRKPSGLHLTLPDFQETETGSQSAPSLAVSRLEQAMSEVSAISSAHKHGPAYIWTTLERIWLQAGELFIADGRMKEAQFCVQEAGTLFPTSHSVLLLKGWVAELKGNDTEAKSLYDEALAINPRGHHILLHLGKLLVRTGRVGLGEKMLRDAIQVQNTAHEAWSGLGEALQSIGSPQAPDCFLTALELESSCPIRPFTIIPREL
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [340-835]
- IPR019734: Tetratricopeptide repeat (repeat) [403-836]
- IPR051722: Endocytosis and PI4K-regulating protein (family) [9-848]
- IPR045819: Tetratricopeptide repeat protein 7, N-terminal (domain) [1-392]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: V-set and transmembrane domain-containing protein 2-like protein (A0A0R4ILX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MGSFGGMFWILHWIALYVQISSKLAVDNHVSGNALFTEVPADVFSRAGEDVEMSCSFRGSSSSSVSLEIQWWYSRQWAEPLPWATNQVVSQENASKGATKISVVKVVGSNISHKLRLSNVKPSDEGTYECRVIDFSENRVQRHQVQAYLQIQRTEEETSENQQKKEKQILHHHHPHHLYEENKTRTQ
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [36-133]
- IPR007110: Immunoglobulin-like domain (domain) [34-146]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [35-168]
- IPR051102: Immunoglobulin superfamily V-set and transmembrane domain-containing protein (family) [2-161]
- IPR013106: Immunoglobulin V-set domain (domain) [39-143]
- IPR003599: Immunoglobulin domain subtype (domain) [40-152]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043523 (regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0005576 (extracellular region)
Protein: Angiomotin (A0A8M2BL72)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction
Sequence: MFRKKASSSLRMRGISENNRRSVDRARSSSFHEVGRSRDLEMRAAASVSEDTSANNSGGSGHTVLQRLLQEQMRYGEGRNYLALQQQQQQGPVSGYPGPGSPADEHSMVPHIARQEPQGQELQVDSGMEKLSTRTAGGGGGSGGTGSLGGSCVSGQMQNPEDLPTYDQAKVQSQYFRGHQPQQPQPQMPPTVGAAFYVTGVTNSKVRPPEGRSTVQRMNGGKVHQDDGLKDLKQGHVRSLSERLMQLSLATSGVKAHAPVTSSPLSPQLPPPGLPGDYYKPTGPPHRGPPPDYPFKGMPSPPKQQQHHQPQHQEPGHFHPDHRGTSQPARTDIPHVRYQPPPEYGSFRSSKESSSHSQRSVHHHSPSSSVTSGGSLSRAQSSTLSSILAASHALPPMGHSGEPPFPIGARSSQGPGSHQGDPYGPGHPPHQRSHVFPHDHYGSAPRGLHMLQHQYHQQGPQQQQQQSPAQHYSHPLSMQGDPYAMLARAQQMVDMLSEENRLLKQELEVCGEKVSKLQKMETEIQMVSEAYENLAKSSTKREALEKTMRNKLEMEVRRVHDFNRDLRERMETANKQLAAKECEGTEDNRKTISQLLVQVKENQREKEKLEIELNSLRSTTEDQRRHIEIRDQALNNAQAKVVKLEEELKKKQVYVEKVERMQQALAQLQAACEKREQLEHRLRTRLERELESLRMQQRQGGSQSTVGPEFSTAALMEHLREKEERILALEADMTKWEQKYLEESVMRQFALDAAASVATQRDTSSAIISHSPSSSYDTSVEARIQKEEEEILMANRRCLDMESRIKNLHAQIIEKDAMIKVLHQRSRKEPASKLDTPAMRPSKSLMSIATGTGGSSGSGLLSHSLGLSGSSPITEERREDRSWKGSLGVLLGPEFRGDSLRTESISSSPSPVLPSTPMPLATHSKTGSRDSCTQTEKSQENSKPSTPALQNVPGPSRISSPSPVYIPDRIADVPVFHSSTLERRAPVQSLPPASVAAQDMDSDMVEILI
InterPro domains: - IPR009114: Angiomotin (family) [538-829]
- IPR051747: Angiomotin-like (family) [59-1009]
- IPR024646: Angiomotin, C-terminal (domain) [654-855]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0007163 (establishment or maintenance of cell polarity), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0090132 (epithelium migration), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0010631 (epithelial cell migration), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0001667 (ameboidal-type cell migration), GO:0043542 (endothelial cell migration), GO:0043534 (blood vessel endothelial cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099512 (supramolecular fiber), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber)