Protein: Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) (Q86V21)
Organism: Homo sapiens (Human)
Function: Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JMI1}.
Sequence: MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF
InterPro domains: - IPR042099: ANL, N-terminal domain (homologous_superfamily) [25-541]
- IPR005914: Acetoacetyl-CoA synthase (family) [16-670]
- IPR032387: Acetyl-coenzyme A synthetase, N-terminal domain (domain) [47-104]
- IPR000873: AMP-dependent synthetase/ligase domain (domain) [110-488]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [543-664]
- IPR020845: AMP-binding, conserved site (conserved_site) [287-298]
Interaction partners: - Hydroxymethylglutaryl-CoA lyase, mitochondrial
- Acetyl-CoA acetyltransferase, mitochondrial
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic
- Acetyl-CoA acetyltransferase, cytosolic
- Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
- Peroxisomal bifunctional enzyme
- Hydroxymethylglutaryl-CoA synthase, mitochondrial
- 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
- Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
- Dehydrogenase/reductase SDR family member 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0006644 (phospholipid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0006084 (acetyl-CoA metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)