Protein: GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed] (Q61411)
Organism: Mus musculus (Mouse)
Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20171}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Shuttles between the plasma membrane and the Golgi apparatus. The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). {ECO:0000250}.
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
InterPro domains: - IPR001806: Small GTPase (family) [1-188]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-171]
- IPR005225: Small GTP-binding domain (domain) [1-159]
- IPR020849: Small GTPase, Ras-type (family) [3-166]
Interaction partners: - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Son of sevenless homolog 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- RAF proto-oncogene serine/threonine-protein kinase
- Ral guanine nucleotide dissociation stimulator
- Afadin
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Zinc fingers and homeoboxes protein 2
- Ras-specific guanine nucleotide-releasing factor 1
- Leucine-rich repeat protein SHOC-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0003008 (system process), GO:0009893 (positive regulation of metabolic process), GO:0030029 (actin filament-based process), GO:0001763 (morphogenesis of a branching structure), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0012501 (programmed cell death), GO:0048729 (tissue morphogenesis), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0009314 (response to radiation), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0050886 (endocrine process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0070997 (neuron death), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0007611 (learning or memory), GO:0030900 (forebrain development), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0008284 (positive regulation of cell population proliferation), GO:0035239 (tube morphogenesis), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0048167 (regulation of synaptic plasticity), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0014009 (glial cell proliferation), GO:0061138 (morphogenesis of a branching epithelium), GO:0030036 (actin cytoskeleton organization), GO:0060249 (anatomical structure homeostasis), GO:0048872 (homeostasis of number of cells), GO:0061061 (muscle structure development), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0060322 (head development), GO:0045596 (negative regulation of cell differentiation), GO:0007632 (visual behavior), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0099177 (regulation of trans-synaptic signaling), GO:0001894 (tissue homeostasis), GO:0060425 (lung morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0060251 (regulation of glial cell proliferation), GO:0010001 (glial cell differentiation), GO:0002009 (morphogenesis of an epithelium), GO:0050769 (positive regulation of neurogenesis), GO:0010468 (regulation of gene expression), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0048168 (regulation of neuronal synaptic plasticity), GO:0007417 (central nervous system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007264 (small GTPase mediated signal transduction), GO:0050890 (cognition), GO:0009416 (response to light stimulus), GO:1901215 (negative regulation of neuron death), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0050804 (modulation of chemical synaptic transmission), GO:0021782 (glial cell development), GO:0060479 (lung cell differentiation), GO:1901214 (regulation of neuron death), GO:0010628 (positive regulation of gene expression), GO:0007612 (learning), GO:0051960 (regulation of nervous system development), GO:0060252 (positive regulation of glial cell proliferation), GO:0035914 (skeletal muscle cell differentiation), GO:0030855 (epithelial cell differentiation), GO:0008542 (visual learning), GO:0022008 (neurogenesis), GO:0030324 (lung development), GO:0030323 (respiratory tube development), GO:0051402 (neuron apoptotic process), GO:0060537 (muscle tissue development), GO:0006915 (apoptotic process), GO:0030857 (negative regulation of epithelial cell differentiation), GO:0048873 (homeostasis of number of cells within a tissue), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:1902531 (regulation of intracellular signal transduction), GO:0030856 (regulation of epithelial cell differentiation), GO:0060541 (respiratory system development), GO:0048169 (regulation of long-term neuronal synaptic plasticity), GO:0042981 (regulation of apoptotic process), GO:0014002 (astrocyte development), GO:0043523 (regulation of neuron apoptotic process), GO:0051057 (positive regulation of small GTPase mediated signal transduction), GO:0007519 (skeletal muscle tissue development), GO:0032228 (regulation of synaptic transmission, GABAergic), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0043524 (negative regulation of neuron apoptotic process), GO:0050767 (regulation of neurogenesis), GO:0060538 (skeletal muscle organ development), GO:0043066 (negative regulation of apoptotic process), GO:0042063 (gliogenesis), GO:0051146 (striated muscle cell differentiation), GO:0014015 (positive regulation of gliogenesis), GO:0060428 (lung epithelium development), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0060441 (epithelial tube branching involved in lung morphogenesis), GO:0060487 (lung epithelial cell differentiation), GO:0048708 (astrocyte differentiation), GO:0008306 (associative learning), GO:0046578 (regulation of Ras protein signal transduction), GO:0016601 (Rac protein signal transduction), GO:0046579 (positive regulation of Ras protein signal transduction), GO:0014013 (regulation of gliogenesis), GO:0035020 (regulation of Rac protein signal transduction), GO:0035022 (positive regulation of Rac protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)