wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: GEL complex subunit OPTI (Obligate partner of TMCO1 insertase) (Rab5-interacting protein) (RIP5) (Respirasome Complex Assembly Factor 1) (RCAF1) (Q9CQT9)
Organism: Mus musculus (Mouse)
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (By similarity). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0A8I3S9V6}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:31536960}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWDDKDEFLDVIYWFRQIIALVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVIWIIFYTAIHYD
InterPro domains: - IPR029008: ER membrane protein complex subunit 6-like (family) [44-123]
- IPR010742: Respirasome Complex Assembly Factor 1 (family) [1-128]
Interaction partners: - Calcium load-activated calcium channel
- TBC1 domain family member 31
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Basic helix-loop-helix (BHLH) DNA-binding superfamily protein (F4KAJ5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MEDIVDQELSNYWEPSSFLQNEDFEYDRSWPLEEAISGSYDSSSPDGAASSPASKNIVSERNRRQKLNQRLFALRSVVPNITKMDKASIIKDAISYIEGLQYEEKKLEAEIRELESTPKSSLSFSKDFDRDLLVPVTSKKMKQLDSGSSTSLIEVLELKVTFMGERTMVVSVTCNKRTDTMVKLCEVFESLNLKILTSNLTSFSGMIFHTVFIELRPNIYWVVWFLVFMSIFGPTIIVIWSIWFIKKKIILSLWRMKKNKRCCG
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [51-106]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [48-117]
- IPR054502: Plant bHLH transcription factor, ACT-like domain (domain) [157-214]
- IPR051358: Transcription factor AMS/ICE1/BHLH6-like (family) [41-214]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Branched-chain amino acid ABC transporter, periplasmic substrate-binding protein (Q5LUN2)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Function: Not known
Sequence: MSKNQVTRRGVLKTGAVAGAGVALPTIFTASSAAAYTNEPTGGTVTLGFNVPQTGPYADEGNDELLAQQLAVEHLNGMGDGGCLNTFTSKALKGNGILGKKVQFVTGDTQTKSDAARASAKSMIEKDGAIMINGGSSSGVAVAVQGLCQDAGVIFMAGLTHANDTTGKDRKANGFRHFFNAYMSGAALAPVLAKEMGSDRRAYHLTADYNWGWTQEESIVASTEALGWETVNTVKTPLASTDFSSYIAPVLNSGADVLVLNHYGGNMVNSLTNAIQFGLLDKVANGKDFKIVVPLYSELMAAGAGDNIKGVLGSMNYNWQLDNEGSRAFVKSFGEKYGKPPSNSAQTCYAQVLLYADACERAGTFNPCGVVEALEGFEFDGLGNGKTLYRADDHQCFKDVLVVRGAQNPTNAYDTLEIVEVTPVAQVMYPPNHPMFGGDEATLGQCNPGA
InterPro domains: - IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [44-432]
- IPR051010: Branched-chain amino acid transport protein (family) [20-415]
- IPR006311: Twin-arginine translocation pathway, signal sequence (conserved_site) [1-35]
- IPR028081: Leucine-binding protein domain (domain) [44-404]
Interaction partners: - Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, permease protein
- Branched-chain amino acid ABC transporter, ATP-binding protein
- Branched-chain amino acid ABC transporter, periplasmic substrate-binding protein
- Branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid binding protein
- Branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid binding protein, putative
- Branched-chain amino acid ABC transporter, periplasmic substrate-binding protein
- Branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding protein
- ABC transporter, periplasmic substrate-binding protein, putative
- Branched-chain amino acid ABC transporter, periplasmic substrate-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0043168 (anion binding), GO:0043177 (organic acid binding), GO:0031406 (carboxylic acid binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015849 (organic acid transport), GO:0006865 (amino acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015803 (branched-chain amino acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: Ras-related protein Rab-1A (EC 3.6.5.2) (Q8I3W9)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MTENRSRDYDYLYKIILIGDSGVGKSCILLRFSDDHFTESYITTIGVDFRFRTIKVDDKIVKLQIWDTAGQERFRTITSAYYRGADGIIIIYDTTDRNSFLHINDWMNEINKYTNEDTCKLLVGNKADCKDDIEITTMEGQNKAKELNISFIETSAKDATNVELAFTMITQELIKKKKKKNFTSLKNNHAKLKLSTHDNSPQSFCSC
InterPro domains: - IPR057289: Rab1/Ypt1 (family) [11-174]
- IPR005225: Small GTP-binding domain (domain) [11-169]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [5-207]
- IPR050305: Small GTPase superfamily, Rab (family) [6-195]
- IPR001806: Small GTPase (family) [4-207]
Interaction partners: - Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- Trafficking protein particle complex subunit
- GDP dissociation inhibitor, putative
- Rab GDP dissociation inhibitor
- Trafficking protein particle complex subunit 6A, putative
- Trafficking protein particle complex subunit 8, putative
- Trafficking protein particle complex subunit 2, putative
- Vacuolar protein sorting-associated protein 33, putative
- Rab-GAP TBC domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071704 (organic substance metabolic process), GO:0140352 (export from cell), GO:0033036 (macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0032940 (secretion by cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0016482 (cytosolic transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Phenylalanine ammonia-lyase (EC 4.3.1.24) (Q6UD65)
Organism: Populus trichocarpa x Populus deltoides
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|RuleBase:RU003955}.
Sequence: MEFCQDSRNGNGSLGFNTNDPLNWGMAAESLKGSHLDEVKRMIEEYRKPVVKLGGETLTIGQVTAIASRDVGVMVELSEEARAGVKASSDWVMDSMSKGTDSYGVTTGFGATSHRRTKQGGELQKELIRFLNAGIFGNDTESSHTLPRSATRAAMLVRFNTLLQGYSGIRFEMLEAITKLLNHNITPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPNGEPLSPAEAFTQAGIDGGFFELQPKEGLALVNGTAVGSGLASMVLFETNVLAILSEVLSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKEAQKLHEIDPLQKPKQDRYALRTSPQWLGPLIEVIRTSTKMIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNTRLAIASIGKLMFAQFSELVNDFYNNGLPSNLTGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTAEAVDILKLMSTTFLVGLCQAVDLRHIEENLKSTVKNTVSQVAKRVLTMGFNGELHPSRFCEKDLLKVVDREHVFSYIDDPCSATYPLMQKLRQVLVEHALVNGERETNSTTSIFQKIGSFEEELKTLLPKEVESARLEVENGNPAIPNRIKECRSYPLYKFVREELGTSLLTGEKVKSPGEEFDKVFTAICAGKLIDPLLECLKEWDGAPLPIC
InterPro domains: - IPR023144: Phenylalanine ammonia-lyase, shielding domain superfamily (homologous_superfamily) [524-645]
- IPR022313: Phenylalanine/histidine ammonia-lyases, active site (active_site) [193-209]
- IPR001106: Aromatic amino acid lyase (family) [20-711]
- IPR005922: Phenylalanine ammonia-lyase (family) [20-701]
- IPR008948: L-Aspartase-like (homologous_superfamily) [20-711]
- IPR024083: Fumarase/histidase, N-terminal (homologous_superfamily) [12-257]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0043168 (anion binding), GO:0043177 (organic acid binding), GO:0031406 (carboxylic acid binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0120254 (olefinic compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0009698 (phenylpropanoid metabolic process), GO:0009699 (phenylpropanoid biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0120255 (olefinic compound biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042537 (benzene-containing compound metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Rubrerythrin diiron-binding domain-containing protein (Q729F3)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Not known
Sequence: MAEFFNAADVTAAAIRIEQRGQDVYRQAVAMTTNPEVRALFEHLAAEEAKHEATFRAMADRVGPVELPAWSIAAEYVEYLHALLDSHALFTQSGTLTSLKGAADDHATALQMAIQFEKDTLLFFTEMRNLVPASEKAAVDACIDEERAHLRALTAMLVQAKRS
InterPro domains: - IPR003251: Rubrerythrin, diiron-binding domain (domain) [12-156]
- IPR012347: Ferritin-like (homologous_superfamily) [1-160]
- IPR009078: Ferritin-like superfamily (homologous_superfamily) [12-157]
Interaction partners: - Hydrogenase, putative
- Hydrogenase, iron-sulfur cluster-binding subunit, putative
- Hydrogenase, putative
- Heterodisulfide reductase, C subunit
- Heterodisulfide reductase, A subunit
- Heterodisulfide reductase, B subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0010646 (regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Transmembrane 4 L6 family member 20 (Q53R12)
Organism: Homo sapiens (Human)
Function: Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
Subcellular location: Membrane {ECO:0000269|PubMed:23810381}; Multi-pass membrane protein {ECO:0000269|PubMed:23810381}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25310401}; Multi-pass membrane protein {ECO:0000269|PubMed:25310401}. Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. {ECO:0000269|PubMed:27499293}.
Sequence: MTCCEGWTSCNGFSLLVLLLLGVVLNAIPLIVSLVEEDQFSQNPISCFEWWFPGIIGAGLMAIPATTMSLTARKRACCNNRTGMFLSSLFSVITVIGALYCMLISIQALLKGPLMCNSPSNSNANCEFSLKNISDIHPESFNLQWFFNDSCAPPTGFNKPTSNDTMASGWRASSFHFDSEENKHRLIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSKRRSQIV
InterPro domains: - IPR008661: L6 membrane (family) [2-227]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010976 (positive regulation of neuron projection development), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Hairy/enhancer-of-split related with YRPW motif protein 1 (XHey-1) (Hairy and enhancer of split-related protein 1) (Hesr-1) (Hairy-related transcription factor 1) (HRT-1) (XHRT1) (xHRT-1) (Protein xbc8) (Q9I8A3)
Organism: Xenopus laevis (African clawed frog)
Function: Downstream effector of Notch signaling. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Acts as a suppressor of neurogenesis by antagonizing proneural gene function. Functions during floorplate development. Plays a role in pronephros formation in the inhibition of distal tubule and duct cell fates and the promotion of glomus and proximal tubule formation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:14648848}.
Sequence: MKRGHDYSSSDSELDENIEVEKESADENGNLSSMSPSTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGMETADPLRVRLVSHLNNYASQREAASTAHTSIGHIPWGGTFAHHPHLSHPLLLAQTAHTNSTSSSTEAHHHNRLRGSPHAESSSLRVAPNGNIASVLPVVASSKLSPPLLSSMASLSAFPFSFGSFHLLSPNSLSPTTPTPSGKPYRPWGTEIGAF
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [44-105]
- IPR003650: Orange domain (domain) [115-162]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [38-102]
- IPR050370: Hairy and Enhancer of Split/HEY-related (family) [40-287]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0001708 (cell fate specification), GO:0045165 (cell fate commitment), GO:0030154 (cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Olfactory receptor 51B5 (Odorant receptor HOR5'beta5) (Olfactory receptor OR11-37) (Q9H339)
Organism: Homo sapiens (Human)
Function: Odorant receptor.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MSSSGSSHPFLLTGFPGLEEAHHWISVFFLFMYISILFGNGTLLLLIKEDHNLHEPMYFFLAMLAATDLGLALTTMPTVLGVLWLDHREIGSAACFSQAYFIHSLSFLESGILLAMAYDRFIAICNPLRYTSVLTNTRVVKIGLGVLMRGFVSVVPPIRPLYFFLYCHSHVLSHAFCLHQDVIKLACADTTFNRLYPAVLVVFIFVLDYLIIFISYVLILKTVLSIASREERAKALITCVSHICCVLVFYVTVIGLSLIHRFGKQVPHIVHLIMSYAYFLFPPLMNPITYSVKTKQIQNAILHLFTTHRIGT
InterPro domains: - IPR000725: Olfactory receptor (family) [29-306]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [39-290]
- IPR050402: Olfactory receptor 51/52/56-like (family) [6-305]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [24-298]
Interaction partners: - Guanine nucleotide-binding protein G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0007608 (sensory perception of smell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Probable two-component-system connector protein AriR (P75993)
Organism: Escherichia coli (strain K12)
Function: Probably a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; AriR probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein.
Sequence: MLEDTTIHNAITDKALASYFRSSGNLLEEESAVLGQAVTNLMLSGDNVNNKNIILSLIHSLETTSDILKADVIRKTLEIVLRYTADDM
InterPro domains: - IPR024753: Regulatory protein AriR (family) [29-87]
Interaction partners: - Probable two-component-system connector protein YmgA
- Uncharacterized protein YmgC
- Probable two-component-system connector protein YcgZ
- HTH-type transcriptional repressor BluR
- Blue light- and temperature-regulated antirepressor BluF
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)