Protein: Phosphoglycerate kinase 2 (P07205)
Organism: Homo sapiens (Human)
Function: Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity)
Subcellular location: Cytoplasm
Sequence: MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVLMSHLGRPDGVPMPDKYSLAPVAVELKSLLGKDVLFLKDCVGAEVEKACANPAPGSVILLENLRFHVEEEGKGQDPSGKKIKAEPDKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGMAYTFLKVLNNMEIGASLFDEEGAKIVKDIMAKAQKNGVRITFPVDFVTGDKFDENAQVGKATVASGISPGWMGLDCGPESNKNHAQVVAQARLIVWNGPLGVFEWDAFAKGTKALMDEIVKATSKGCITVIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKILPGVEALSNM
InterPro domains: - IPR015911: Phosphoglycerate kinase, conserved site (conserved_site) [18-28]
- IPR036043: Phosphoglycerate kinase superfamily (homologous_superfamily) [6-416]
- IPR015824: Phosphoglycerate kinase, N-terminal (homologous_superfamily) [1-416]
- IPR001576: Phosphoglycerate kinase (family) [4-416]
Interaction partners: - Glyceraldehyde-3-phosphate dehydrogenase
- Triosephosphate isomerase
- Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
- Phosphoglycerate mutase 2
- Phosphoglycerate mutase 1
- Bisphosphoglycerate mutase
- Probable phosphoglycerate mutase 4
- Glucose-6-phosphate isomerase
- Phosphoglycerate kinase 1
- Alpha-enolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0047134 (protein-disulfide reductase (NAD(P)) activity), GO:0015036 (disulfide oxidoreductase activity), GO:0016774 (phosphotransferase activity, carboxyl group as acceptor), GO:0016301 (kinase activity), GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051093 (negative regulation of developmental process), GO:0044238 (primary metabolic process), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0070482 (response to oxygen levels), GO:0019637 (organophosphate metabolic process), GO:0019538 (protein metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901343 (negative regulation of vasculature development), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0009888 (tissue development), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:1901575 (organic substance catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0071456 (cellular response to hypoxia), GO:0006753 (nucleoside phosphate metabolic process), GO:0006508 (proteolysis), GO:0071453 (cellular response to oxygen levels), GO:0006757 (ATP generation from ADP), GO:0043436 (oxoacid metabolic process), GO:1901342 (regulation of vasculature development), GO:0051604 (protein maturation), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0030855 (epithelial cell differentiation), GO:0019693 (ribose phosphate metabolic process), GO:0036293 (response to decreased oxygen levels), GO:0045765 (regulation of angiogenesis), GO:0016052 (carbohydrate catabolic process), GO:0060429 (epithelium development), GO:0010467 (gene expression), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0016310 (phosphorylation), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0036294 (cellular response to decreased oxygen levels), GO:0006163 (purine nucleotide metabolic process), GO:0016485 (protein processing), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0031638 (zymogen activation), GO:0032787 (monocarboxylic acid metabolic process), GO:0046031 (ADP metabolic process), GO:0006090 (pyruvate metabolic process), GO:0046034 (ATP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0098857 (membrane microdomain), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0045121 (membrane raft), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)