Protein: Tyrosine-protein kinase (A0A8M2B201)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane. Cytoplasm
Sequence: MVDKVHLLPYFFGNITREESEVYLQQGGSGDGLYLLRQSRSFLGGYALSLSYGRQFYHYTIERELNDTYAIAGGKSHRTPIDVINYHSQESDGLICLLKKPFHRPRGTEPKVGPFEDLKEQLIRQYVEQTWNLKGSALDQAIISQRPQLEKLIATTAHEKMPWFHGKIDREDSELRLLNTSRVNGKFLIRQRENSGRNESYALCLLHNNQVMHYRIDKDRAGKLSIPDGKKFDTLWQLVEHYSYKPDGLLRVLTETCPRPSHHSERGATGGIISRLKSYSFPKPGQKKGSAENPYKITPNGKDDYSKQGNFLDSAMPMDTQVYESPYADPDELRSTKVNRSDLTLEDGELGSGNFGTVLRGVYQMKKTQKVVAVKILKNDDDNAAVKDEMLREANVMQQLDNPYIVRMIGICEAENLMLVMELAELGPLHKFLQKNKHITVKNLTELVHQVSMGMKYLEEHNFVHRDLAARNVLLVTQHYAKISDFGLSKALTEDENYYKAKGHGKWPLKWYAPECMNYLKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGNEVIQMIENGQRMSAPPDCPPEMYDLMKKCWTYKPDERPGFSVVEPRLRHYYYDISQ
InterPro domains: - IPR012234: Tyrosine-protein kinase, non-receptor SYK/ZAP-70 (family) [1-608]
- IPR035838: SYK/ZAP-70, N-terminal SH2 domain (domain) [8-111]
- IPR023420: Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily (homologous_superfamily) [113-154]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [1-363]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [349-597]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [348-599]
- IPR017441: Protein kinase, ATP binding site (binding_site) [350-375]
- IPR000719: Protein kinase domain (domain) [344-604]
- IPR000980: SH2 domain (domain) [8-257]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [145-595]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [463-475]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [344-599]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0010632 (regulation of epithelial cell migration), GO:2000145 (regulation of cell motility), GO:0036303 (lymph vessel morphogenesis), GO:0048731 (system development), GO:0001945 (lymph vessel development), GO:0001946 (lymphangiogenesis), GO:2000147 (positive regulation of cell motility), GO:0010594 (regulation of endothelial cell migration), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0010634 (positive regulation of epithelial cell migration), GO:0030335 (positive regulation of cell migration), GO:0030334 (regulation of cell migration), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0010595 (positive regulation of endothelial cell migration), GO:0043536 (positive regulation of blood vessel endothelial cell migration), GO:0090049 (regulation of cell migration involved in sprouting angiogenesis), GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)