Protein: Fibronectin type III and SPRY domain-containing protein 1 (Q1LY10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May be involved in microtubule organization and stabilization.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=Cell-cycle-dependent association with the centrosome. Colocalizes with a subpopulation of microtubules. Does not associate with microtubules during mitosis but reassociates with microtubules during cytokinesis. Localizes to the central portions of a small subset of microtubules in interphase cells and a subpopulation of microtubules in the cleavage furrow, not present in the mitotic spindle (By similarity). {ECO:0000250}.
Sequence: MDDQKESLRKIITTLALKNEEIQNFICSLKQSLENLEANSNRVQEDLESEFSSLHSVLDDLKEGMVTRIKQERASRTYELQSQLGACTKALESSEELLEFANQTLCSSENDSFTQAAKDIKDSVTMAPAFRLSLKAKASDSMNHMMVDFTHERNLLQSITFLPVPATPEIHVADCQVFDNTVTVVWTLPEPDSKIDHYILEHRKTNHEGPPRAREDYPWMVVEGIKETEYTLTGVRFDTRYMTFRVKACNKAVAGEFSEPVTLETHAFVFKLDASSSHQNLKVEDLSVEWDSSGGKVAVQDIRKEKNRTNSPMHSPARTAMMSPKRAPSARVGRDRFTAESYTVLGDTMIDAGQHYWEVRFDKESKAFAAGVALRSLGRFDQLGKSNASWCIHLNNWLQQSLTAKHNNKARTLDCSIPDRIGIYCNYEEGTLSFYNSRNKTLLHTFRTKFQQPVIPAFMVWNGSFSVQTGLQVPSIVLSGQKRNSNTSSSNASLT
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [156-268]
- IPR003961: Fibronectin type III (domain) [164-268]
- IPR003877: SPRY domain (domain) [352-473]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [319-474]
- IPR017903: COS domain (domain) [105-162]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [164-263]
- IPR003879: Butyrophylin-like, SPRY domain (domain) [266-460]
- IPR001870: B30.2/SPRY domain (domain) [281-476]
- IPR035742: Fibronectin type III and SPRY containing 1, PRY/SPRY domain (domain) [270-475]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [264-469]
- IPR003649: B-box, C-terminal (domain) [4-130]
- IPR050617: E3 ubiquitin-protein ligases and FN3/SPRY domain-containing proteins (family) [3-477]
Interaction partners: - ADAM metallopeptidase domain 10b.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0031109 (microtubule polymerization or depolymerization), GO:0007020 (microtubule nucleation), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0097435 (supramolecular fiber organization), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0065003 (protein-containing complex assembly), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0046785 (microtubule polymerization), GO:0051258 (protein polymerization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0005813 (centrosome), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)