Protein: Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) (P42772)
Organism: Homo sapiens (Human)
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9230210}. Note=Also found in the nucleus.
Sequence: MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [12-138]
- IPR002110: Ankyrin repeat (repeat) [19-110]
- IPR050776: Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor (family) [16-136]
Interaction partners: - Cyclin-dependent kinase 4
- Cyclin-dependent kinase 6
- G1/S-specific cyclin-D1
- Myc proto-oncogene protein
- G1/S-specific cyclin-D2
- Cyclin-dependent kinase inhibitor 2A
- G1/S-specific cyclin-D3
- Cyclin-dependent kinase inhibitor 1
- Cellular tumor antigen p53
- Cyclin-dependent kinase inhibitor 1B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030291 (protein serine/threonine kinase inhibitor activity), GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity), GO:0004861 (cyclin-dependent protein serine/threonine kinase inhibitor activity), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0019899 (enzyme binding), GO:0140297 (DNA-binding transcription factor binding), GO:0019900 (kinase binding), GO:0003723 (RNA binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0019901 (protein kinase binding), GO:0051059 (NF-kappaB binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0044092 (negative regulation of molecular function), GO:0008285 (negative regulation of cell population proliferation), GO:0001558 (regulation of cell growth), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0051726 (regulation of cell cycle), GO:0042127 (regulation of cell population proliferation), GO:0007162 (negative regulation of cell adhesion), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0030308 (negative regulation of cell growth), GO:0009889 (regulation of biosynthetic process), GO:0090398 (cellular senescence), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0045786 (negative regulation of cell cycle), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0043086 (negative regulation of catalytic activity), GO:0010812 (negative regulation of cell-substrate adhesion), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010810 (regulation of cell-substrate adhesion), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051338 (regulation of transferase activity), GO:0007264 (small GTPase mediated signal transduction), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0001953 (negative regulation of cell-matrix adhesion), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0031399 (regulation of protein modification process), GO:1904030 (negative regulation of cyclin-dependent protein kinase activity), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0001952 (regulation of cell-matrix adhesion), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0007265 (Ras protein signal transduction), GO:0043549 (regulation of kinase activity), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0051348 (negative regulation of transferase activity), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0045859 (regulation of protein kinase activity), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0000792 (heterochromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)