Protein: Metal transporter CNNM4 (Q6P4Q7)
Organism: Homo sapiens (Human)
Function: Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MAPVGGGGRPVGGPARGRLLLAAPVLLVLLWALGARGQGSPQQGTIVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLELTKDLVVQQLVNVSRGNTSGVLVVLTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEAGKENMKFETGAFSYYGTMALTSVPSDRSPAHPTPLSRSASLSYPDRTDVSTAATLAGSSNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQFPIDGCTTHMENLAEKSELPVVDETTTLLNERNSLLHKASHENAI
InterPro domains: - IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [579-718]
- IPR046342: CBS domain superfamily (homologous_superfamily) [359-511]
- IPR044751: Ion transporter-like, CBS domain (domain) [372-501]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [588-732]
- IPR000644: CBS domain (domain) [445-511]
- IPR000595: Cyclic nucleotide-binding domain (domain) [575-652]
- IPR045095: Ancient conserved domain protein family (family) [154-736]
- IPR057492: Metal transporter CNNM1/2/4, immunoglobulin-like domain (domain) [46-175]
- IPR002550: CNNM, transmembrane domain (domain) [178-358]
Interaction partners: - Cystathionine beta-synthase
- Cytochrome c oxidase assembly protein COX11, mitochondrial
- Protein tyrosine phosphatase type IVA 2
- Protein tyrosine phosphatase type IVA 1
- Matrix metalloproteinase-20
- Solute carrier family 41 member 1
- GMP synthase [glutamine-hydrolyzing]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050801 (monoatomic ion homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0009887 (animal organ morphogenesis), GO:0097186 (amelogenesis), GO:0009888 (tissue development), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0031214 (biomineral tissue development), GO:0070166 (enamel mineralization), GO:0055080 (monoatomic cation homeostasis), GO:0042476 (odontogenesis), GO:0010960 (magnesium ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0034505 (tooth mineralization), GO:0006812 (monoatomic cation transport), GO:0042475 (odontogenesis of dentin-containing tooth), GO:0030001 (metal ion transport), GO:0015693 (magnesium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)