Protein: Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK) (P42679)
Organism: Homo sapiens (Human)
Function: Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9171348}. Membrane {ECO:0000269|PubMed:9171348}. Note=In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
Sequence: MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [228-480]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [235-478]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [51-140]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [92-480]
- IPR001452: SH3 domain (domain) [48-110]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [117-252]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [236-478]
- IPR017441: Protein kinase, ATP binding site (binding_site) [241-262]
- IPR000719: Protein kinase domain (domain) [235-482]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [348-360]
- IPR035027: CSK-like, SH2 domain (domain) [118-215]
- IPR000980: SH2 domain (domain) [120-211]
Interaction partners: - High affinity nerve growth factor receptor
- BDNF/NT-3 growth factors receptor
- NT-3 growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
- Signaling lymphocytic activation molecule
- CD48 antigen
- Receptor-type tyrosine-protein phosphatase C
- Proteasome subunit alpha type-7
- Small ribosomal subunit protein uS9
- Tyrosine-protein phosphatase non-receptor type substrate 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0051018 (protein kinase A binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016301 (kinase activity), GO:0034236 (protein kinase A catalytic subunit binding), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0004713 (protein tyrosine kinase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051051 (negative regulation of transport), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0051224 (negative regulation of protein transport), GO:0030155 (regulation of cell adhesion), GO:0060627 (regulation of vesicle-mediated transport), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0043170 (macromolecule metabolic process), GO:0050867 (positive regulation of cell activation), GO:0006793 (phosphorus metabolic process), GO:0002696 (positive regulation of leukocyte activation), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0050865 (regulation of cell activation), GO:0031295 (T cell costimulation), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0070201 (regulation of establishment of protein localization), GO:0006796 (phosphate-containing compound metabolic process), GO:0032880 (regulation of protein localization), GO:0036211 (protein modification process), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0051251 (positive regulation of lymphocyte activation), GO:1904376 (negative regulation of protein localization to cell periphery), GO:1905476 (negative regulation of protein localization to membrane), GO:1904950 (negative regulation of establishment of protein localization), GO:0051249 (regulation of lymphocyte activation), GO:0050870 (positive regulation of T cell activation), GO:1905475 (regulation of protein localization to membrane), GO:0050863 (regulation of T cell activation), GO:0006468 (protein phosphorylation), GO:0050851 (antigen receptor-mediated signaling pathway), GO:0016310 (phosphorylation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:1904375 (regulation of protein localization to cell periphery), GO:1903077 (negative regulation of protein localization to plasma membrane), GO:1903076 (regulation of protein localization to plasma membrane), GO:0050852 (T cell receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)