Protein: Receptor-type tyrosine-protein phosphatase-like ida-1 (Dense-core vesicle membrane protein ida-1) (Related to islet cell diabetic autoantigen protein) (G5EGJ5)
Organism: Caenorhabditis elegans
Function: Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15180830, ECO:0000305|PubMed:15044551}; Single-pass type I membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:15044551, ECO:0000269|PubMed:15180830}. Cell projection, axon {ECO:0000269|PubMed:15044551, ECO:0000269|PubMed:15180830}. Cell projection, dendrite {ECO:0000269|PubMed:15180830}. Note=Localizes to dense-core vesicles along axons. {ECO:0000269|PubMed:15044551, ECO:0000269|PubMed:15180830}.
Sequence: MRFFHSIIVLLFSISTGSAFLLYGCNLSENLCDNDESCYPDGVFGQCYSSESGSPEPTVLDNLDDTQLELLKLELTRLAAKDKDWGDEETQCVLAYFKMSMFYQLQYDPDFCQVRKPANVWALIQLIDTGLTEDPTILDEDVNPENVTDEDMAQIIEQLKEPSLPTEEDIEEALNAQNEDVDDEILDQYVQAVVNNENPDFSELSDGQLNILIGRLVDLKKNVENEEAQLLTGDGEQEMAVPLDDLEERGEQAILKKDIEQVGEINQGLDNTEHKIVKGRKDQVVTRVDANRVYLKVHLKNEDQLMPLIEFLQNTIAIPNNLYFDDFQFENGQLSMRISRFEGAKPKADKRIDSVEGVASAVYKRRKDIARLSGADVRETGIGSGEDGSLPVESSERDWLLMPVLFVCAFTVTALGLVAAVQIARSRRHYKDNIQQIAEQLDGKNSFAYQDLCRQRADGGRASKSSSTSSWCEETAVPTIDISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEERTKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEKNYWPDTGSEVHGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLKSIATK
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [472-765]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [675-747]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [653-755]
- IPR033522: Receptor-type tyrosine-protein phosphatase-like N/N2 (family) [251-764]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [501-758]
Interaction partners: - Neuroendocrine convertase 2
- Carboxypeptidase E
- Neuropeptide-Like Protein
- Calcium-dependent secretion activator
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0048731 (system development), GO:0044087 (regulation of cellular component biogenesis), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:1902115 (regulation of organelle assembly), GO:0033043 (regulation of organelle organization), GO:0060491 (regulation of cell projection assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1902017 (regulation of cilium assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0008021 (synaptic vesicle), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070382 (exocytic vesicle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)