Protein: RNA-binding protein fxr1 (Q5BJ56)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis and muscle development (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (By similarity)
Subcellular location: Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, Stress granule. Cytoplasm. Nucleus. Note=Specifically localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity). Nuclear very early in embryonic development (at two hours post-fertilization), becoming cytoplasmic in later embryonic stages through to adulthood
Sequence: MEDLAVEVRGSNGAYYKGFVKDVHEDSLTVVFENNWQPERQVPFHEVRMPPLPDIKKEITEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPGNQNKSVTKSSFFKCTVDVPEDLREPCSNENVHKEFKKAVGACRVYFHAETNQLIILSACESTVKRVTILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGITAIELDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNETKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSSRGTEKEKGYATDESTASSVRGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKEELSDWSLAGEDERESRQQRDSRRRPGGRGRSGSAGRGRGGSRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHNTNRRRRSRRRRTDEDSSLMDGMTESDNASVNENGLDDSEQKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPKEPLAKGKKEKVKDVIEEHGPSEKVINGPRAASADKALKPQTTERNKASCQDGSKQEAILNGVS
InterPro domains: - IPR047494: RNA-binding protein FXR1, first type I K homology domain (domain) [123-199]
- IPR047496: RNA-binding protein FXR2, third type I K homology domain (domain) [281-358]
- IPR004087: K Homology domain (domain) [217-356]
- IPR040472: Synaptic functional regulator FMRP, KH0 domain (domain) [123-207]
- IPR047427: RNA-binding protein FXR1, second Tudor-like Agenet domain (domain) [61-126]
- IPR040148: Fragile X messenger ribonucleoprotein 1 (family) [1-638]
- IPR008395: Agenet-like domain (domain) [62-114]
- IPR032177: Fragile X-related 1 protein, C-terminal region 3 (domain) [610-673]
- IPR022034: Fragile X messenger ribonucleoprotein 1-like, C-terminal core (domain) [354-477]
- IPR041560: FMR1, tudor domain (domain) [4-115]
- IPR047495: RNA-binding protein FXR1, second type I K homology domain (domain) [218-280]
- IPR004088: K Homology domain, type 1 (domain) [221-346]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [216-377]
- IPR032172: Fragile X-related protein 1, C-terminal region 1 (domain) [490-564]
Interaction partners: - Fragile X messenger ribonucleoprotein 1 homolog
- Sulfotransferase
- Protein argonaute-2
- Tudor domain-containing protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007389 (pattern specification process), GO:0009790 (embryo development), GO:0061061 (muscle structure development), GO:0048513 (animal organ development), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0048731 (system development), GO:0035282 (segmentation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0007517 (muscle organ development), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0072359 (circulatory system development), GO:0009952 (anterior/posterior pattern specification), GO:0007507 (heart development), GO:0060537 (muscle tissue development), GO:0007519 (skeletal muscle tissue development), GO:0060538 (skeletal muscle organ development), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)