Protein: Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR) (O76070)
Organism: Homo sapiens (Human)
Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11746666}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11746666}. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Sequence: MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD
InterPro domains: - IPR001058: Synuclein (family) [1-122]
- IPR002462: Gamma-synuclein (family) [45-127]
Interaction partners: - Myocilin
- Thy-1 membrane glycoprotein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0001101 (response to acid chemical), GO:0010035 (response to inorganic substance), GO:0002118 (aggressive behavior), GO:0104004 (cellular response to environmental stimulus), GO:0009415 (response to water), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0071229 (cellular response to acid chemical), GO:1901215 (negative regulation of neuron death), GO:0071462 (cellular response to water stimulus), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0062197 (cellular response to chemical stress), GO:1902075 (cellular response to salt), GO:1901214 (regulation of neuron death), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0043279 (response to alkaloid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)