Protein: ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (P46561)
Organism: Caenorhabditis elegans
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (Probable). Required during male mating behavior for the response to hermaphrodite contact, acting with lov-1 and pkd-2. May be involved in polycystin signaling.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:15563610}. Mitochondrion {ECO:0000269|PubMed:15563610}. Mitochondrion inner membrane {ECO:0000269|PubMed:15563610}. Note=Peripheral membrane protein. Localizes to the cilium only in male-specific sensory neurons.
Sequence: MASRSLASISRSASRLLQSNVQKCALPAASIRLSSNNVESKKGIHTGVATQQAAAATKVSAKATAANASGRIVAVIGAVVDVQFDENLPPILNGLEVVGRSPRLILEVSQHLGDNVVRCIAMDGTEGLVRGQPVADTGDPIKIPVGPETLGRIMNVIGEPIDERGPIASKNFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIEGGVIDLKGKNSKVSLVYGQMNEPPGARARVCLTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGSMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRGIAELAIYPAVDPLDSTSRIMDPNVVGQNHYDIARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHQGKFVSLEETIRGFTMILKGELDHLPEVAFYMQGGIDDVFKKAEELAKQHGN
InterPro domains: - IPR050053: ATPase alpha/beta chains (family) [55-533]
- IPR024034: ATPase, F1/V1 complex, beta/alpha subunit, C-terminal (homologous_superfamily) [417-537]
- IPR000194: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain (domain) [195-414]
- IPR003593: AAA+ ATPase domain (domain) [207-391]
- IPR055190: ATP synthase A/B type, C-terminal domain (domain) [419-509]
- IPR020003: ATPase, alpha/beta subunit, nucleotide-binding domain, active site (active_site) [405-414]
- IPR004100: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain (domain) [72-138]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [141-419]
- IPR005722: ATP synthase, F1 complex, beta subunit (family) [67-532]
- IPR036121: ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily (homologous_superfamily) [67-140]
Interaction partners: - ATP synthase subunit a
- ATP synthase subunit delta, mitochondrial
- ATP synthase subunit d
- ATP synthase subunit alpha, mitochondrial
- Oligomycin sensitivity conferral protein
- F-ATPase gamma subunit
- ATP synthase c subunit
- ATP synthase-coupling factor 6
- ATP synthase F
- ATP synthase subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0005996 (monosaccharide metabolic process), GO:0098771 (inorganic ion homeostasis), GO:0005975 (carbohydrate metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0044262 (cellular carbohydrate metabolic process), GO:0019318 (hexose metabolic process), GO:0055080 (monoatomic cation homeostasis), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0006006 (glucose metabolic process), GO:0045333 (cellular respiration), GO:0006874 (intracellular calcium ion homeostasis), GO:0022904 (respiratory electron transport chain), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)