Protein: Multidrug resistance protein D (P31442)
Organism: Escherichia coli (strain K12)
Function: Multidrug resistance pump that participates in a low energy shock adaptive response.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Sequence: MKRQRNVNLLLMLVLLVAVGQMAQTIYIPAIADMARDLNVREGAVQSVMGAYLLTYGVSQLFYGPISDRVGRRPVILVGMSIFMLATLVAVTTSSLTVLIAASAMQGMGTGVGGVMARTLPRDLYERTQLRHANSLLNMGILVSPLLAPLIGGLLDTMWNWRACYLFLLVLCAGVTFSMARWMPETRPVDAPRTRLLTSYKTLFGNSGFNCYLLMLIGGLAGIAAFEACSGVLMGAVLGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPDWFGVMNVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLASLSAMLPQTGQGSLGLLMTLMGLLIVLCWLPLATRMSHQGQPV
InterPro domains: - IPR011701: Major facilitator superfamily (family) [14-349]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [5-388]
- IPR004734: Multidrug resistance protein (family) [50-186]
- IPR020846: Major facilitator superfamily domain (domain) [9-388]
Interaction partners: - Glycerol-3-phosphate transporter
- Lactose permease
- Multidrug export protein EmrB
- Multidrug resistance protein MdtG
- Multidrug resistance protein MdtK
- Probable aminoglycoside efflux pump
- Multidrug resistance protein MdtH
- Probable multidrug resistance protein EmrK
- Multidrug export protein EmrA
- Multidrug efflux pump subunit AcrA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0022821 (solute:potassium antiporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0015385 (sodium:proton antiporter activity), GO:0015386 (potassium:proton antiporter activity), GO:0051139 (metal cation:proton antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0140352 (export from cell), GO:0140115 (export across plasma membrane), GO:0046618 (xenobiotic export from cell), GO:0009636 (response to toxic substance), GO:0006810 (transport), GO:0046618 (xenobiotic export from cell), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0042908 (xenobiotic transport), GO:0015850 (organic hydroxy compound transport), GO:0015695 (organic cation transport), GO:0015846 (polyamine transport), GO:0015848 (spermidine transport), GO:0015847 (putrescine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)