Protein: Protein disabled (P98081)
Organism: Drosophila melanogaster (Fruit fly)
Function: Together with Abl, involved in embryonic neural development. May have a role in eye development. Acts as an adapter protein for SH2-domain containing proteins during sevenless (sev) signaling.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7680635}.
Sequence: MVKSLVAKLSTASSNLSLASTFGGGSGAAEETNYAKHRNDPGRFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEIEMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTSSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTSLDAMLSPPPGTSSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTASTAASLGQLLSTVALNPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKANVFNGPLQVQLPPEKELQLQQPPSTVRNRPTASVSALPSGGALDVISSISNKKMPHLFGQARSFGKSGSDIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTPYSEPPPLPPKKQFSDLVIRPSPANTTQPPTSGRYEYLNSNVTARRTASSVDAPPIPLPSRRVGRSDGCFPGPGRPRKPGHTEDDYLAPLGAPPPLLPPPSQGSSARARPQRQASLGRPQDIYENKAEILQAQAQAQAQAPEVAPSSNTLAPDITLTQLLTLGMDDLAIKLNVPASKLSTMTLVQLTAYLSEYLSSEKSQVHSQERRSSPANTAPAPASTAAVFKVNFDQQTSFVAKFDDTFGEDEPVMPSGSSDSTFVANFANFNDAPTPVPTVSPVVATVPSADRYAVFREIIDQELQQQQQETDLMGDLTPPPVDETQAKEISEGLEVNNVGAELPIDALDVKPAPKIDTKITEVVAQAKDRYAALRDIILVENLFDKPAIATDTQPEKEKDLLQDFPEFSDEFNEDHDLRQIMDHQNVQTHARDRHGLVDSRGFPTEPSSSALTVGDYDEDEDADAGGESSLDSNEKDAEPVSGQDQYEKLSTSTQQLDAAAPALEDVQQLQQQSLPPKQDQKFLSILTAPGGGTKDDIEIDELMHRAISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGMGPSPVPSQLSAVSQLIDTATKQMMGDKDREKQSWATFDSPKAKGKARLTLPPPPPPASNTSQPDTVESPCSSDPRDDGWSKQQRRWAKKERQQTSSSSRDLSPWDDETPEYLKRRQLAAAQMAHPHQPPMQAPPQHTDRHGYYMRHARRMNSCDEDYDYDGEFVARRDQPQHQQQQRKFKHGLSRSRDNFELESPSWYHHPAHHTWSPQEIEQVRVRSFDRTAYERSSYGPPPPIYDKRGQLRGKYRGDHRDRERERDRDREYRDYARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYDRERDRDRERDRKSFDRESLESYESATRRRRSFGSGNDVYGSLDSRDDYRGDRERDRERDREQMKTRSLRKPTTTSGKLRISGDIDYEQDSEQDFQQRSGVRSLQRPNQLGGDVVLPSNAVVGPQRLRKSSGSSPWDGEEPALPGQKSWKRPASAAETERRLAESRRAVALGQTPSDGEKERRFRKKTRARSAKDLATVGAPSASTSAPSRSSYGRGIRDNYDYICPGQRNDDDDDDDEDYVDDEPPTDEDKFERLNRRRHEMHQRMLESERRQMERHQPPSLAKLPGQNRTRGVVANSDYGFVDSYEQTPTPTPRSNASSTGPGGLMMSGGESSAGVTSSKFNFDDGFESDFNQSSPPPAPAGTASSCNSTPAGPVSANANNGGSKSLFRFSNDFSDREKREQFEMDTPPTSTPPITQKLRFDDNVKVSQFDDAAFEDDFAKASFDFEKEQAGSATAGAGGSGAMSRKQNMRTSKLQQRQELIKKSESVNIFAKKQEDPFEDDEFFKSPDQEQAMDQHNDDTEGGKFQWSEDANFAKFDENM
InterPro domains: - IPR006020: PTB/PI domain (domain) [46-197]
- IPR048561: Disabled, phosphotyrosine-binding domain (domain) [35-181]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [35-188]
Interaction partners: - Myosin heavy chain 95F
- Unconventional myosin IC
- Neurogenic locus Notch protein
- Tyrosine-protein kinase Abl
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0090130 (tissue migration), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0051302 (regulation of cell division), GO:0009968 (negative regulation of signal transduction), GO:0061351 (neural precursor cell proliferation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:1903828 (negative regulation of protein localization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0001708 (cell fate specification), GO:0060255 (regulation of macromolecule metabolic process), GO:0008356 (asymmetric cell division), GO:0000902 (cell morphogenesis), GO:0009894 (regulation of catabolic process), GO:0009887 (animal organ morphogenesis), GO:0140013 (meiotic nuclear division), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0055057 (neuroblast division), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0007297 (follicle cell of egg chamber migration), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0007276 (gamete generation), GO:0045597 (positive regulation of cell differentiation), GO:0010648 (negative regulation of cell communication), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060341 (regulation of cellular localization), GO:0090132 (epithelium migration), GO:0051649 (establishment of localization in cell), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0009880 (embryonic pattern specification), GO:0009891 (positive regulation of biosynthetic process), GO:0045165 (cell fate commitment), GO:0001709 (cell fate determination), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0017145 (stem cell division), GO:0045664 (regulation of neuron differentiation), GO:0010631 (epithelial cell migration), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0051246 (regulation of protein metabolic process), GO:0008593 (regulation of Notch signaling pathway), GO:0060251 (regulation of glial cell proliferation), GO:0050769 (positive regulation of neurogenesis), GO:0007350 (blastoderm segmentation), GO:0007298 (border follicle cell migration), GO:0010468 (regulation of gene expression), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0045995 (regulation of embryonic development), GO:0048813 (dendrite morphogenesis), GO:0009953 (dorsal/ventral pattern formation), GO:0051252 (regulation of RNA metabolic process), GO:0048858 (cell projection morphogenesis), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0030100 (regulation of endocytosis), GO:0007405 (neuroblast proliferation), GO:0030100 (regulation of endocytosis), GO:0007405 (neuroblast proliferation), GO:0030100 (regulation of endocytosis), GO:0007405 (neuroblast proliferation), GO:0035282 (segmentation), GO:0055059 (asymmetric neuroblast division), GO:0031344 (regulation of cell projection organization), GO:0048663 (neuron fate commitment), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0048477 (oogenesis), GO:2000179 (positive regulation of neural precursor cell proliferation), GO:0010506 (regulation of autophagy), GO:0032880 (regulation of protein localization), GO:0051960 (regulation of nervous system development), GO:0008589 (regulation of smoothened signaling pathway), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0030866 (cortical actin cytoskeleton organization), GO:0046552 (photoreceptor cell fate commitment), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0045732 (positive regulation of protein catabolic process), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0030162 (regulation of proteolysis), GO:2001141 (regulation of RNA biosynthetic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0150063 (visual system development), GO:0007010 (cytoskeleton organization), GO:0007427 (epithelial cell migration, open tracheal system), GO:1902692 (regulation of neuroblast proliferation), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:1900180 (regulation of protein localization to nucleus), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0031401 (positive regulation of protein modification process), GO:0035330 (regulation of hippo signaling), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0046530 (photoreceptor cell differentiation), GO:0006355 (regulation of DNA-templated transcription), GO:0006897 (endocytosis), GO:0045862 (positive regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0002052 (positive regulation of neuroblast proliferation), GO:0001932 (regulation of protein phosphorylation), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0048749 (compound eye development), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)