Protein: Methionine aminotransferase (EC 2.6.1.88) (Methionine-oxo-acid transaminase) (P77806)
Organism: Escherichia coli (strain K12)
Function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine.
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MTNNPLIPQSKLPQLGTTIFTQMSALAQQHQAINLSQGFPDFDGPRYLQERLAHHVAQGANQYAPMTGVQALREAIAQKTERLYGYQPDADSDITVTAGATEALYAAITALVRNGDEVICFDPSYDSYAPAIALSGGIVKRMALQPPHFRVDWQEFAALLSERTRLVILNTPHNPSATVWQQADFAALWQAIAGHEIFVISDEVYEHINFSQQGHASVLAHPQLRERAVAVSSFGKTYHMTGWKVGYCVAPAPISAEIRKVHQYLTFSVNTPAQLALADMLRAEPEHYLALPDFYRQKRDILVNALNESRLEILPCEGTYFLLVDYSAVSTLDDVEFCQWLTQEHGVAAIPLSVFCADPFPHKLIRLCFAKKESTLLAAAERLRQL
InterPro domains: - IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [45-284]
- IPR004839: Aminotransferase, class I/classII, large domain (domain) [32-383]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [10-386]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [22-383]
- IPR051326: Kynurenine--oxoglutarate transaminase (family) [10-385]
Interaction partners: - HTH-type transcriptional regulator MetR
- Hydroxycarboxylate dehydrogenase A
- Cystathionine gamma-synthase
- 5,10-methylenetetrahydrofolate reductase
- Bifunctional aspartokinase/homoserine dehydrogenase 2
- Homoserine O-succinyltransferase
- Bifunctional chorismate mutase/prephenate dehydratase
- Cystathionine beta-lyase MetC
- Probable S-methylmethionine permease
- Uncharacterized protein YbdM
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0019842 (vitamin binding), GO:0043168 (anion binding), GO:0016769 (transferase activity, transferring nitrogenous groups), GO:0070279 (vitamin B6 binding), GO:0008483 (transaminase activity), GO:0030170 (pyridoxal phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0016999 (antibiotic metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009237 (siderophore metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0017000 (antibiotic biosynthetic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0033067 (macrolide metabolic process), GO:0030638 (polyketide metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901334 (lactone metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006518 (peptide metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019290 (siderophore biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0033068 (macrolide biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0030639 (polyketide biosynthetic process), GO:0018958 (phenol-containing compound metabolic process), GO:0043043 (peptide biosynthetic process), GO:1901336 (lactone biosynthetic process), GO:0009712 (catechol-containing compound metabolic process), GO:0046189 (phenol-containing compound biosynthetic process), GO:0019184 (nonribosomal peptide biosynthetic process), GO:0009713 (catechol-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)