wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Conserved hypothetical prophage protein (D2TRA0)
Organism: Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280)
Function: Not known
Sequence: MSQTQTEAEIFTLKYPFTTAAGNSIAQLTLNRLTVKDLKQIKKTHKNPTDWDEPLISRSTGLLPEDLDNMDLADYLELQDRFQKITGLGKKHDSADKGAGAAGEVVPVPAGGD
InterPro domains: - IPR019289: Tail assembly protein E/E' (family) [11-84]
Interaction partners: - Phage tail protein
- Phage tail spike protein
- Conserved hypothetical prophage protein
- Phage tail protein
- Phage baseplate protein
- Phage baseplate protein
- Phage tail protein
- Phage tail tube protein
- Phage tail fibre protein
- Phage tail sheath protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0004518 (nuclease activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019068 (virion assembly), GO:0019069 (viral capsid assembly), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Protein-glucosylgalactosylhydroxylysine glucosidase (E7EMA9)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MEDAGEDPTTFAAHSLPSDPRLLATVTNAYLGTRVFHDTLHVSGVYNGAGGDTHRAMLPSPLNVRLEAPAGMGEQLTETFALDTNTGSFLHTLEGPRFRASQCIYAHRTLPHVLAFRVSIARLAPGSGPITLLLRSAFSPESPDLDLHQGPDFQGARYLYGHTLTPEQPGGPQQEVHMLWTPAPPDLTLGEGEEARTWDFLTAVGGSQAEAQACLTEALQLQARGALYTAHAQAWAQLWVECGLDVVGPLQLRQALRGSLYYLLSALPQPKAPGYICHGLSPGGLSNGSREECYWGHVFWDQDLWMFPSILMFHPEAARAILEYRIRTLDGALENAQNLGYQGAKFAWESADSGLEVCPEDIYGVQEVHVNGAVVLAFELYYHTTQDLQLFREAGGWDVVRAVAEFWCSRVEWSPREEKHLTCASPTLTTGVEGRPLRLCTEHHLGLVCPGVMSPDEYHSGVNNSVYTNVLVQNSLRFAAALAQDLGLPIPSQWLAVADKIKVPFDVEQNFHPEFDGYEPGEVVKQADVVLLGYPVPFSLSPDVRRKNLEIYEAVTSPQGPAMTWSMFAVGWMELKDAVRARGLLDRSFANMAEPFKVWTENADGSGAVNFLTGMGGFLQAVVFGCTGFRVTRAGVTFDPVCLSGISRVSVSGIFYQGNKLNFSFSEDSVTVEVTARAGPWAPHLEAELWPSQSRLSLLPGHKVSFPRSAGRIQMSPPKLPGSSSSEFPGRTFSDVRDPLQSPLWVTLGSSSPTESLTVDPASE
InterPro domains: - IPR012341: Six-hairpin glycosidase-like superfamily (homologous_superfamily) [252-621]
- IPR005195: Glycoside hydrolase, family 65, central catalytic (domain) [288-518]
- IPR008928: Six-hairpin glycosidase superfamily (homologous_superfamily) [205-674]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0005975 (carbohydrate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Forkhead box protein I1-B (FoxI1-B) (FoxI1b) (xFoxI1b) (Fork head domain-related protein 2') (xFD-2') (xFD2') (Q91905)
Organism: Xenopus laevis (African clawed frog)
Function: Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the 'non-neural' versus 'neural' cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site.
Subcellular location: Nucleus {ECO:0000255, ECO:0000305}.
Sequence: MNPVQQPAQHRSPASLLHLPHPKRAQEAPDMGLYCDNFMFSQQNLHPSQRAPNFSIGGEFTPPANPYLWLGGPGMNNAPNYSPAPAPYIPSAFSAPQRHFMANSAAFGGADLGWMSAASQEELLKMVRPPYSYSALIAMAIQNASDKRLTLSQIYQYVAENFPFYKKSKAGWQNSIRHNLSLNDCFKKMPRDENDPGKGNYWTLDSNCEKMFDNGNFRRKRKPKSESNNAKIAKRDEDHLNPKGKESPPMITPSSSPEVLSPTGHSKSPSPPTVTYTPCLTNFIGSMTAVDSATMNRQSPLGLLNELSQRNITGLSSFISGSAVDQSSEHQDNSLFYNRSPYYTNQKQPHFLQQLHPQQPPLYQGRY
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [127-222]
- IPR050211: Forkhead box domain-containing protein (family) [36-328]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [172-178]
- IPR001766: Fork head domain (domain) [126-222]
- IPR018122: Fork head domain conserved site1 (conserved_site) [128-141]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [115-223]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0009799 (specification of symmetry), GO:0009855 (determination of bilateral symmetry), GO:0009953 (dorsal/ventral pattern formation), GO:0007398 (ectoderm development), GO:0048264 (determination of ventral identity), GO:0048262 (determination of dorsal/ventral asymmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: GlyPicaN (G5EGU4)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Sequence: MFSDTLAWLLILLLAMPQETHGFYFTRRDIHGVMCSSSFEDQCTMEERSRLQTNTVDMLTRKHQDRVIVIRSFLTSQIRIFNEFFSKTLRTVHMDLDLMFSKTYGSFYQENIQLLNDFFKKIKGFSVSFAETSMKTIVELFFDELFQVMFSIANPFYSITNDQRVCMESFYREIEAFDDIPQKIVNQLSLPLSNWKHFLGSLESLNGILEGYLNITFKEECERGLTRMETCAQCQRISEKPCQAYCVNILSGCTHQMLDSEGAWRAATESMIKLGNQLNHRQNLVSALQPIPVLISEAIMHFQEKRDYITNKMIGKCLLNNEDFGLRKKRSAKFKAFPVITTKRSRDHLILNQMFQSFANKMDEWKVFFGNLPEYLCRGEDWASKEDERCWNGTGVGEYKLPLVNYTNPFSNPEYQGTDFLTFRGNYIEERLRLHWLHSRISHILSGKDSQKSEAYYSHKAEARIQSDDEDYSDYEYESSGNFPGSGSYMSSKREYSPYFRKHDDKIEIVIEPYPVISTSRKHFHSFVIVIFMLFSALFQCSR
InterPro domains: - IPR001863: Glypican (family) [31-491]
Interaction partners: - Probable syndecan
- LONg
- Heparan-sulfate 6-O-sulfotransferase
- D-glucuronyl C5-epimerase
- Netrin receptor unc-5
- Sulfotransferase domain-containing protein
- Heparan sulfate 2-O-sulfotransferase hst-2
- Fibronectin type-III domain-containing protein
- Sulfotransferase domain-containing protein
- Agrin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0010647 (positive regulation of cell communication), GO:0030111 (regulation of Wnt signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:2000027 (regulation of animal organ morphogenesis), GO:0090175 (regulation of establishment of planar polarity), GO:2000052 (positive regulation of non-canonical Wnt signaling pathway), GO:2000050 (regulation of non-canonical Wnt signaling pathway), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:2000095 (regulation of Wnt signaling pathway, planar cell polarity pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)
Protein: mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) (Q4FKP8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MNCRKRGESVTLMESLRTAASYDQVVKKRAGDMKSKETPFRFFSNYVKKCLIQCALDHIKVTTGRRDAIVLDLASGRGGDLGKWLHCQSPELSFATAKLPRERLTKAAYVECYDVSPECIAEAESRYKKIAPDTVCRCSFTVKDCFSEDFLLRELPLTQHFGKFDIVSIQFAFHYACDTLERIDMLLGAIARALAPEGVFIATTVDEEVLAKRVAANRMESKGLFSIHFDSEPQFEYDRLVVGTRYRFNLDGFVDCDEYVVPLDYVRDCAKQHGLEEMVKFSKHFGSFYETYKDDPSKNKERYLVGGEMELATLYRSLCFRKAS
InterPro domains: - IPR039753: mRNA cap guanine-N7 methyltransferase (family) [19-323]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [33-323]
- IPR004971: mRNA (guanine-N(7))-methyltransferase domain (domain) [35-323]
Interaction partners: - Nuclear cap-binding protein subunit 2
- Cap-specific mRNA
- Transcription initiation protein, putative
- RNA guanylyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0036260 (RNA capping), GO:0006370 (7-methylguanosine mRNA capping), GO:0009452 (7-methylguanosine RNA capping)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Odorant receptor 47b (P81922)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Plays an important role in sociosexual interactions since its enhances courtship in a pheromone-dependent manner.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Sequence: MNDSGYQSNLSLLRVFLDEFRSVLRQESPGLIPRLAFYYVRAFLSLLCQYPNKKLASLPLYRWINLFIMCNVMTIFWTMFVALPESKNVIEMGDDLVWISGMALVFTKIFYMHLRCDEIDELISDFEYYNRELRPHNIDEEVLGWQRLCYVIESGLYINCFCLVNFFSAAIFLQPLLGEGKLPFHSVYPFQWHRLDLHPYTFWFLYIWQSLTSQHNLMSILMVDMVGISTFLQTALNLKLLCIEIRKLGDMEVSDKRFHEEFCRVVRFHQHIIKLVGKANRAFNGAFNAQLMASFSLISISTFETMAAAAVDPKMAAKFVLLMLVAFIQLSLWCVSGTLVYTQSVEVAQAAFDINDWHTKSPGIQRDISFVILRAQKPLMYVAEPFLPFTLGTYMLVLKNCYRLLALMQESM
InterPro domains: - IPR004117: Olfactory receptor, insect (family) [41-409]
Interaction partners: - Odorant receptor 88a
- Odorant receptor 67d
- Odorant receptor 56a
- Odorant receptor 47a
- Odorant receptor 23a
- Odorant receptor 22a
- Ionotropic receptor 84a
- Odorant receptor 43a
- Putative odorant receptor 83c
- Odorant receptor 67b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004984 (olfactory receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0051606 (detection of stimulus), GO:0042221 (response to chemical), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050877 (nervous system process), GO:0009593 (detection of chemical stimulus), GO:0007600 (sensory perception), GO:0050907 (detection of chemical stimulus involved in sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0050911 (detection of chemical stimulus involved in sensory perception of smell), GO:0007608 (sensory perception of smell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Cystatin-like protein (P23779)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNVVKSLCILGLVLVSLIATQAADEQVVGGVSQLEGNSRKEALELLDATLAQLATGDGPSYKAINVTSVTGQVVAGSLNTYEVELDNGSDKKQCTVKIWTQPWLKENGTNIKIKCSGDDGELDRTW
InterPro domains: - IPR053128: Cystatin-like inhibitors (family) [3-108]
- IPR046350: Cystatin superfamily (homologous_superfamily) [24-118]
- IPR000010: Cystatin domain (domain) [26-116]
- IPR018073: Proteinase inhibitor I25, cystatin, conserved site (conserved_site) [71-84]
Interaction partners: - Superoxide dismutase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0009991 (response to extracellular stimulus), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:0031669 (cellular response to nutrient levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Clavesin-1 (Cellular retinaldehyde-binding protein-like) (Retinaldehyde-binding protein 1-like 1) (clathrin vesicle-associated Sec14 protein 1) (Q8IUQ0)
Organism: Homo sapiens (Human)
Function: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:19651769}; Peripheral membrane protein {ECO:0000269|PubMed:19651769}.
Sequence: MGPVSLLPKYQKLNTWNGDLAKMTHLQAGLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTSSNLERECSPKLMKRSQSVVEAGTLKHEEKGENENTQPLLALD
InterPro domains: - IPR011074: CRAL/TRIO, N-terminal domain (domain) [70-97]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [122-287]
- IPR036273: CRAL/TRIO, N-terminal domain superfamily (homologous_superfamily) [23-102]
- IPR001251: CRAL-TRIO lipid binding domain (domain) [118-279]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0043168 (anion binding), GO:0005543 (phospholipid binding), GO:0080025 (phosphatidylinositol-3,5-bisphosphate binding), GO:0035091 (phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007033 (vacuole organization), GO:0080171 (lytic vacuole organization), GO:0007040 (lysosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0032588 (trans-Golgi network membrane), GO:0031982 (vesicle), GO:0005802 (trans-Golgi network), GO:0097708 (intracellular vesicle)
Protein: Serine hydroxymethyltransferase (EC 2.1.2.1) (Q7SXN1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MSQRNGHTEKTWESHNKMMLEPLSTNDPEVFDIIKKEKKRQTYGLELIASENFTSRAVLEALGSCMNNKYSEGYPGQRYYGGTEHVDELERLCQDRALKVYGLDPEKWGVNVQPYSGSRANFAVYTAIVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPETGYIDYNRLEENARLFHPRLIIAGTSCYSRNLDYSRLRKIADENGAYLLADMAHISGLVAAGVVPSPFEYCDVVSTTTHKTLRGCRAGVIFFRKGVRSVDAKTGKETMYNLESLINQAVFPGLQGGPHNHAIAGVAVALKQALTPEFKTYQLQVLANCKALASALMDKGYKVVTGGSDNHLILVDLRSNGTDGGRAEKVLEACAIACNKNTCPGDKSALRPSGLRLGSPALTSRGLLEEHFHKVAEFIHQGIVLTLEIQKNMNPKATLKEFKEELSQNEKYQLKTKEIRKEVEDFAGKFPMPGLPEL
InterPro domains: - IPR019798: Serine hydroxymethyltransferase, pyridoxal phosphate binding site (binding_site) [246-262]
- IPR049943: Serine hydroxymethyltransferase-like (family) [7-479]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [52-326]
- IPR039429: Serine hydroxymethyltransferase-like domain (domain) [23-422]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [12-477]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [27-476]
- IPR001085: Serine hydroxymethyltransferase (family) [3-480]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0016742 (hydroxymethyl-, formyl- and related transferase activity), GO:0004372 (glycine hydroxymethyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0030097 (hemopoiesis), GO:0048863 (stem cell differentiation), GO:0002521 (leukocyte differentiation), GO:0035272 (exocrine system development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0055123 (digestive system development), GO:0030099 (myeloid cell differentiation), GO:0031016 (pancreas development), GO:0031017 (exocrine pancreas development), GO:0002573 (myeloid leukocyte differentiation), GO:0030851 (granulocyte differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Inner membrane protein YmgF (P58034)
Organism: Escherichia coli (strain K12)
Function: Could be involved in cell division. May participate in the stabilization of the cell divisome under specific conditions.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:18978050}; Multi-pass membrane protein {ECO:0000269|PubMed:18978050}. Note=Localizes to the division septum. Localization requires FtsZ, FtsA, FTsQ and FtsN.
Sequence: MNNSNNLDYFTLYIIFSIAFMLITLLVILIAKPSTGLGEVLVTINLLNALVWLAINLVNRLRERLVNHRDQQ
InterPro domains: - IPR048171: Cell division-associated protein YmgF (family) [1-72]
Interaction partners: - Cell division protein FtsQ
- Cell division protein FtsL
- Divisome-associated membrane protein Blr
- Cell division protein FtsN
- Peptidoglycan D,D-transpeptidase FtsI
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)