Protein: Ras-like GTP-binding protein RhoL (Q24192)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for the maturation of hemocytes.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Sequence: MTANITKSPRPLKITIVGDGMVGKTCMLITYTRNEFPEEYIPTVFDNHACNIAVDDRDYNLTLWDTAGQEDYERLRPLSYPSTNCFLLCYSISSRTSFENVKSKWWPEIRHFSAHVPVVLVGTKLDLRIPNSEKFVTTQEGKKMRKEIHAFNLVECSAKKKQNLQQVFEEAVRAVERKPKTTSKQSCKIL
InterPro domains: - IPR001806: Small GTPase (family) [7-190]
- IPR003578: Small GTPase Rho (family) [12-184]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [10-190]
- IPR005225: Small GTP-binding domain (domain) [12-170]
Interaction partners: - Stress-activated protein kinase JNK
- Mitogen-activated protein kinase kinase kinase
- Rho guanine nucleotide exchange factor 3, isoform L
- non-specific serine/threonine protein kinase
- Rho GDP-dissociation inhibitor 3
- Serine/threonine-protein kinase PAK mbt
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Rho guanine nucleotide exchange factor at 64C, isoform A
- Cdc42 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0019901 (protein kinase binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0040007 (growth), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042440 (pigment metabolic process), GO:0006955 (immune response), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0019748 (secondary metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0019098 (reproductive behavior), GO:0016049 (cell growth), GO:0016203 (muscle attachment), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0009607 (response to biotic stimulus), GO:0006949 (syncytium formation), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0140253 (cell-cell fusion), GO:0002252 (immune effector process), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0009826 (unidimensional cell growth), GO:0048513 (animal organ development), GO:0007631 (feeding behavior), GO:0010883 (regulation of lipid storage), GO:0006725 (cellular aromatic compound metabolic process), GO:0035010 (encapsulation of foreign target), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0051231 (spindle elongation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0051128 (regulation of cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0006582 (melanin metabolic process), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0002764 (immune response-regulating signaling pathway), GO:1901615 (organic hydroxy compound metabolic process), GO:0002118 (aggressive behavior), GO:0035556 (intracellular signal transduction), GO:0007617 (mating behavior), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:0001505 (regulation of neurotransmitter levels), GO:0030036 (actin cytoskeleton organization), GO:1903036 (positive regulation of response to wounding), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0061061 (muscle structure development), GO:0048598 (embryonic morphogenesis), GO:0050776 (regulation of immune response), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0046843 (dorsal appendage formation), GO:0033554 (cellular response to stress), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0007306 (egg chorion assembly), GO:1903391 (regulation of adherens junction organization), GO:0030030 (cell projection organization), GO:0007520 (myoblast fusion), GO:0000165 (MAPK cascade), GO:0048732 (gland development), GO:0002009 (morphogenesis of an epithelium), GO:0035272 (exocrine system development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0018958 (phenol-containing compound metabolic process), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0022607 (cellular component assembly), GO:0035006 (melanization defense response), GO:0048568 (embryonic organ development), GO:0042692 (muscle cell differentiation), GO:0045995 (regulation of embryonic development), GO:0090303 (positive regulation of wound healing), GO:0007264 (small GTPase mediated signal transduction), GO:0035011 (melanotic encapsulation of foreign target), GO:0007015 (actin filament organization), GO:0030097 (hemopoiesis), GO:0022604 (regulation of cell morphogenesis), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0008258 (head involution), GO:0031532 (actin cytoskeleton reorganization), GO:0046903 (secretion), GO:0045229 (external encapsulating structure organization), GO:0001667 (ameboidal-type cell migration), GO:0050770 (regulation of axonogenesis), GO:0042742 (defense response to bacterium), GO:0016192 (vesicle-mediated transport), GO:0007390 (germ-band shortening), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0022612 (gland morphogenesis), GO:0097435 (supramolecular fiber organization), GO:0035099 (hemocyte migration), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060541 (respiratory system development), GO:0006909 (phagocytosis), GO:0008078 (mesodermal cell migration), GO:0051403 (stress-activated MAPK cascade), GO:0035162 (embryonic hemopoiesis), GO:0007424 (open tracheal system development), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0051017 (actin filament bundle assembly), GO:0007391 (dorsal closure), GO:0061041 (regulation of wound healing), GO:0008360 (regulation of cell shape), GO:0007431 (salivary gland development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0060538 (skeletal muscle organ development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007435 (salivary gland morphogenesis), GO:0016476 (regulation of embryonic cell shape), GO:0051146 (striated muscle cell differentiation), GO:0061572 (actin filament bundle organization), GO:0014902 (myotube differentiation), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0010975 (regulation of neuron projection development), GO:0007254 (JNK cascade), GO:0007266 (Rho protein signal transduction), GO:0097581 (lamellipodium organization), GO:0030032 (lamellipodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0032153 (cell division site), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0032154 (cleavage furrow), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0055037 (recycling endosome), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)