Protein: ERAD-associated E3 ubiquitin-protein ligase HRD1B (AtHrd1B) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase HRD1B) (Q6NPT7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3A.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MIQLKVYAGLSTLATLVVIYHAFSSRGQFYPATVYLSTSKINLVVLLNMGLVLMLSLWNLVKIVFLGSLREAEVERLNEQAWRELMEILFAITIFRQDFSVGFISLVVTLLLIKGLHWMAQKRVEYIETTPSVTLLSHVRIVSFMVFLLILDCLLTYSSIQQLIQSRKASMSVFFTFEYMILATTTVSIIVKYAFYVTDMLKEGQWEGKPVYTFYLELVRDLLHLSMYLCFFLMIFMNYGLPLHLIRELYETFRNFKIRVTDYLRYRKITSNMNDRFPDATPEELSSNDATCIICREEMTSAKKLVCGHLFHVHCLRSWLERQNTCPTCRALVVPAENATSTASGNRGPHQESLQQGTGTSSSDGQGSSVSAAASENMSRHEARFQAAASAASIYGRSIVYPSSANTLVWSQGNSLLPQTEVEAQRRFLESQIEVLTNQLRLLEKPTTVDTKGKSVADTA
InterPro domains: - IPR050731: HRD1 family E3 ubiquitin-protein ligases (family) [1-420]
- IPR058051: Synoviolin-like, RING finger (domain) [289-330]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [264-341]
- IPR057992: E3 ubiquitin-protein ligase synoviolin-like, TPR repeats (domain) [4-272]
- IPR001841: Zinc finger, RING-type (domain) [291-330]
Interaction partners: - Protein OS-9 homolog
- ERAD-associated E3 ubiquitin-protein ligase component HRD3A
- Derlin-1
- Derlin-2.1
- Ubiquitin-conjugating enzyme E2 32
- Cell division control protein 48 homolog A
- Derlin-2.2
- ERAD-associated E3 ubiquitin-protein ligase HRD1A
- Peptide-N
- ERAD-associated E3 ubiquitin-protein ligase component HRD3B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0001101 (response to acid chemical), GO:0048316 (seed development), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0010033 (response to organic substance), GO:0048731 (system development), GO:1902074 (response to salt), GO:0061458 (reproductive system development), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140534 (endoplasmic reticulum protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)