Protein: BAR/IMD domain-containing adapter protein 2-like 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2) (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar) (Q6UXY1)
Organism: Homo sapiens (Human)
Function: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:21743456}; Peripheral membrane protein {ECO:0000269|PubMed:21743456}. Cell junction {ECO:0000269|PubMed:21743456}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21743456}. Note=Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts.
Sequence: MAPEMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHALSEAAEVYFSAIQKIGERALQSPTSQILGEILVQMSDTQRHLNSDLEVVVQTFHGGLLQHMEKNTKLDMQFIKDSRQHYELEYRHRAANLEKCMSELWRMERKRDKNVREMKESVNRLHAQMQAFVSESQRAAELEEKRRYRFLAEKHLLLSNTFLQFFGRARGMLQNRVLLWKEQSEASRSPSRAHSPGLLGPALGPPYPSGRLTPTCLDMPPRPLGEFSSPRSRHGSGSYGTEPDARPASQLEPDRRSLPRTPSASSLYSGSAQSSRSNSFGERPGGGGGARRVRALVSHSEGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSASGWFPEAYVKALEEGPVNPMTPVTPMTSMTSMSPMTPMNPGNELPSRSYPLRGSHSLDDLLDRPGNSIAPSEYWDGQSRSRTPSRVPSRAPSPAPPPLPSSRRSSMGSTAVATDVKKLMSSEQYPPQELFPRGTNPFATVKLRPTITNDRSAPLIR
InterPro domains: - IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-229]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [326-410]
- IPR030126: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, I-BAR domain (domain) [6-220]
- IPR035593: Pinkbar, SH3 (domain) [331-385]
- IPR001452: SH3 domain (domain) [324-387]
- IPR027681: I-BAR domain containing protein IRSp53/IRTKS/Pinkbar (family) [4-528]
- IPR013606: IMD/I-BAR domain (domain) [1-239]
Interaction partners: - Dol-P-Man:Man
- Dol-P-Man:Man
- Potassium voltage-gated channel subfamily KQT member 5
- AP-2 complex subunit sigma
- Aftiphilin
- SH3-containing GRB2-like protein 3-interacting protein 1
- Clathrin light chain B
- AP-1 complex subunit sigma-1A
- AP-2 complex subunit alpha-1
- Phosphatidylinositol-binding clathrin assembly protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0005543 (phospholipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0061024 (membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0030054 (cell junction), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005912 (adherens junction), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus), GO:0015629 (actin cytoskeleton)