Protein: Cell division control protein 42 homolog (Q7ZUQ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Midbody
Sequence: MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEISHHCPRTPFLLVGTQVDLRDDSNTVEKLAKNKQRPISPESGEKLSRDLRAVKYVECSALTQRGLKNVFDEAILAALEPPETKPKKRCVLL
InterPro domains: - IPR001806: Small GTPase (family) [1-191]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-182]
- IPR037874: Cdc42 (family) [3-177]
- IPR003578: Small GTPase Rho (family) [3-189]
- IPR005225: Small GTP-binding domain (domain) [1-157]
Interaction partners: - Actin nucleation-promoting factor WAS
- IQ motif-containing GTPase-activating protein 2
- Par-6 family cell polarity regulator gamma b
- Rho GTPase-activating protein 17
- Rho GTPase-activating protein 17
- Catenin (cadherin-associated protein), delta 1
- Vascular endothelial growth factor receptor 2
- Cell division cycle 42-like 2
- FERM, ARHGEF and pleckstrin domain-containing protein 2
- Cell division control protein 42 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045494 (photoreceptor cell maintenance), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0040017 (positive regulation of locomotion), GO:0033059 (cellular pigmentation), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0051875 (pigment granule localization), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051649 (establishment of localization in cell), GO:0051130 (positive regulation of cellular component organization), GO:0051648 (vesicle localization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0060041 (retina development in camera-type eye), GO:0060249 (anatomical structure homeostasis), GO:2000147 (positive regulation of cell motility), GO:0044087 (regulation of cellular component biogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0010632 (regulation of epithelial cell migration), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0001894 (tissue homeostasis), GO:0051128 (regulation of cellular component organization), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0007229 (integrin-mediated signaling pathway), GO:0030030 (cell projection organization), GO:0051905 (establishment of pigment granule localization), GO:0031344 (regulation of cell projection organization), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0007369 (gastrulation), GO:0001895 (retina homeostasis), GO:0030334 (regulation of cell migration), GO:0051650 (establishment of vesicle localization), GO:0001667 (ameboidal-type cell migration), GO:0048666 (neuron development), GO:0060491 (regulation of cell projection assembly), GO:0022607 (cellular component assembly), GO:0022008 (neurogenesis), GO:0051904 (pigment granule transport), GO:0007399 (nervous system development), GO:0010594 (regulation of endothelial cell migration), GO:0048514 (blood vessel morphogenesis), GO:0031346 (positive regulation of cell projection organization), GO:0072359 (circulatory system development), GO:0010634 (positive regulation of epithelial cell migration), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0030335 (positive regulation of cell migration), GO:0032400 (melanosome localization), GO:0006996 (organelle organization), GO:0001822 (kidney development), GO:0002040 (sprouting angiogenesis), GO:0030182 (neuron differentiation), GO:0070925 (organelle assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0042074 (cell migration involved in gastrulation), GO:0051491 (positive regulation of filopodium assembly), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0032402 (melanosome transport), GO:0030031 (cell projection assembly), GO:0046530 (photoreceptor cell differentiation), GO:0120036 (plasma membrane bounded cell projection organization), GO:0010595 (positive regulation of endothelial cell migration), GO:0150063 (visual system development), GO:0042461 (photoreceptor cell development), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0048699 (generation of neurons), GO:0032401 (establishment of melanosome localization), GO:0044782 (cilium organization), GO:0043536 (positive regulation of blood vessel endothelial cell migration), GO:0090049 (regulation of cell migration involved in sprouting angiogenesis), GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis), GO:0060271 (cilium assembly), GO:0051489 (regulation of filopodium assembly), GO:0043010 (camera-type eye development), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development), GO:0046847 (filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)