wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Bis(monoacylglycero)phosphate synthase CLN5 (A0A8M3AVX6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane
Sequence: MKYSVYFLHAVLHCWIVGLVVSIVNGKQVWPVPYKRVDKRPDVDPFCQALYPFCPTGDPAGQIPVMKESDLISIFRLQTPVWEFKYGDIMGKFHIMHDAVGFASANTGRNYTMEWYELFQLGNCTFPHEREGLSAPFWCNQGAACFYEGIDDIHWKQNGSLEKIGEISGKLFNEMARWVQEDNETGVYYETWTVKSDSGANSTTWFDSYDCSQFVHRTYKKLMDLGTQLSSQTPLKYTKIYLYSGEPLYLGDDSIFQQSSTKDLAADIRQFYYSFRSHQSMVEMIKSLLEALEKMVVEKTFYFYYNSQYWKLPMKYPYLKITYEEIPFP
InterPro domains: - IPR026138: Ceroid-lipofuscinosis neuronal protein 5 (family) [5-329]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001501 (skeletal system development), GO:0051216 (cartilage development), GO:0061448 (connective tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pyruvate kinase (Q7ZVT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MSQTKAQDMGSAFIQTQQLNAAMADTFLEHMCLLDIDSEPTIARNTGIICTIGPASRSVDTLKEMIKSGMNIARMNFSHGSHEYHGETIKNVREACASFEPGSIQYRPVGIALDTKGPEIRTGLIKGSGTAEVELKKGNKIKVTLDDSFMENCDEDTLWLDYKNITKVVEVGSKVYIDDGLISLQVLQIGSDYLICEIENGGSLGSKKGVNLPGAAVDLPAVSEKDIKDLQFGVEMGVDMIFASFIRKAADVQAVRKVLGEKGKNIKIISKLENHEGVRRFDEIMEASDGIMVARGDLGIEIPTEKVFLAQKMMIGRCNKAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRTQHMIAREAEAATFHRQLFEGLRRSSVLTRDPSDAVAVGAVEASFKCCASGIIILTKTGRSAHLISRYRPRAPILAVTRNEQTARQAHLYRGIFPIYYNSPSNDVWAEDVDLRVNFAMDVGKARGFFKAGDVVIVLTGWRPGSGYTNTMRVVPVP
InterPro domains: - IPR018209: Pyruvate kinase, active site (active_site) [266-278]
- IPR001697: Pyruvate kinase (family) [16-531]
- IPR015813: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (homologous_superfamily) [16-395]
- IPR015795: Pyruvate kinase, C-terminal (domain) [411-529]
- IPR015806: Pyruvate kinase, insert domain superfamily (homologous_superfamily) [118-220]
- IPR040442: Pyruvate kinase-like domain superfamily (homologous_superfamily) [47-386]
- IPR011037: Pyruvate kinase-like, insert domain superfamily (homologous_superfamily) [118-219]
- IPR015793: Pyruvate kinase, barrel (domain) [44-376]
- IPR036918: Pyruvate kinase, C-terminal domain superfamily (homologous_superfamily) [3-531]
Interaction partners: - L-lactate dehydrogenase A chain
- phosphopyruvate hydratase
- phosphopyruvate hydratase
- Beta-enolase
- Pyruvate dehydrogenase E1 component subunit beta
- L-lactate dehydrogenase B-A chain
- Enolase 4
- L-lactate dehydrogenase B-B chain
- Pyruvate dehydrogenase E1 component subunit alpha
- Pyruvate carboxylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004743 (pyruvate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Glycerophosphodiester phosphodiesterase domain-containing 5b (A0A8M2B4R1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Endomembrane system; Multi-pass membrane protein
Sequence: MVKHQPLQVYERQLCLSCLTGIYGCRWKRYQRSHDDTTKWECLWSLILFFTFSLLLVWFYFWWEAHNDYSEFNWFLYNRSGEWSDGTVPILATTAAGFTYIAFLMILALCHVAVGQQLNLHWVHKIGVTVALLTTIIGVISVTQMWGEEWDVVWISLQATGPFLHIGALAAVTALAWLMAGQVARAEKTRFQAMVLLLYLSVLLTLYFIPLSISSPCIMERGSLKAAPAIIGHQGAPMLAPENTLLSFNRALQRNVSGLETDVTISLDGVPFLMRDRTLRRTTNVRRVFPERQYEDASLFNWTDLSTLNAGQWFLKDDPFWTVQYMSTTERWSVGNQTVCSLEQMLKLAAKYKSSALFTVHRPPVNHPHHHDWVNLTLDTVLGSGIPQGQVMWTVDSNREMVRKVAPGFQQTSMQKLPFDTLHHNGISRLLLRYNQASEQDVRLYKENNISVSLYTVNEPWLYSLLWCSGVPSVSSEAPQVLRKLHYPLWLMTPDEYCLIWISTDLISFAVVLGIFIFQNYHMIRWRMSGMRSYNPEQIMLSAAVRRSSRDVNIMKEKLIFSEVSNGVNGDEAYSENGFNYYTN
InterPro domains: - IPR030395: Glycerophosphodiester phosphodiesterase domain (domain) [228-486]
- IPR017946: PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily (homologous_superfamily) [218-487]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0060560 (developmental growth involved in morphogenesis), GO:0003401 (axis elongation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Hedgehog-interacting protein (A1A5I0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Peripheral membrane protein. Secreted
Sequence: MKHLKFVLLLAIAANFWECGDAKFGEKGELSPRRRRCYDGSLPRRLKKKERKLSLEGSGGGEVCHRLYPRVSCCPSRRAPYQILHRKDARTFSTNNTECSRLLEEIKCAHCSPNAQMLFHSPKLEKAPHREQDLPHLCHDYCQEFYYTCRGHVPELFQADVDEFCQYYGRMDGGLCFPDFHRKQLRRDSNYLLDEKTEAINRKHKHNCYCAQEIHSGLQQPVGVVHCGDGSQRLFILEREGFVWILTHDMELLKEPFLDIHKLVQSGLKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWTIGPHDHILRVVEYTVSRKNPNQVDTRTPRVLMEVAELHRKHLGGQLLFGPDGLLHIFLGDGMITLDNMEEMDGLSDFTGSVLRVDVDTECCSTPYSIPRNNPYFNSTNQPPEIFAHGLHDPGRCAVDKLRMDTNGSLLILCTDTVGKNTTTGRILQVIKGKDYENEPSMFDLGSSGGTTPVGGFIYRGCQSRRLYGSYVFGDKNGNFRILQRPLEDRLWQEKPLCLGTSSSCGSSLVGHILGFGEDELGEVYILVSSKSTAKQSHGKIYKLVDPKRPQVPKECRRPVEDPEMLSTACSRECKNGHCTPTGKCCCNAGWEGPFCLRAKCELACRNGGVCVEPNKCLCKEGFSGNQCSKGERGTKGDGEKDSILEHIIDMTTYLLDLTSYIV
InterPro domains: - IPR011041: Soluble quinoprotein glucose/sorbosone dehydrogenase, beta-propeller domain superfamily (homologous_superfamily) [208-512]
- IPR000742: EGF-like domain (domain) [599-659]
- IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [194-577]
- IPR012938: Glucose/Sorbosone dehydrogenase (domain) [218-428]
- IPR013111: Epidermal growth factor-like domain, extracellular (domain) [631-658]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0050793 (regulation of developmental process), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0023057 (negative regulation of signaling), GO:0048856 (anatomical structure development), GO:0051239 (regulation of multicellular organismal process), GO:0007275 (multicellular organism development), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0048736 (appendage development), GO:0048635 (negative regulation of muscle organ development), GO:0048634 (regulation of muscle organ development), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0033333 (fin development), GO:0008589 (regulation of smoothened signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0005886 (plasma membrane)
Protein: Protein-arginine deiminase type-2 (Q6PFK7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MVSRRSLTIDTEKATKTTYVLGTTLTVNLIRCAPPQSKSFSIRCTPNVHYKITPPITDKNALPYPLGPNTILLITMDTVSETAFDSKLSVRYYGEKTETLGDAILHLTAVEISLDVDADRDGVVEKNNPNKASWKWGPNGHGAILLVNCDSESINNKKPDNENSDIGKVSDLKDMSKMVLRTNGPSQLPEGYKLSMHISQSTSESVRVFRPRTNTKTENLWKYQLLKLFLKDFLMVVGTDTLTQEVPYLGGSSELEFHVEGLRFPDKDFDGLVTINLSLLEPCGKGFPETPIFTDKVVFRVSPWIMTPNTLKPVEVYVCSTEDNYSFLKSIRNLVEKSGYKLKICHEYMNRGDRWMQDFPYDALLGPDFGYVTRNALNEEVSSLDSFGNLEVSPPVTVNGKNYPLGRIIIGVAFPTARKGRNMTKVVQDFLWAQKVQEPIALYSDWLFVGHVDEFMSFVPAPDRKKFRLLLASPDAGYKVFKSLQNSGLGKAEMFPGKEEAISVNDLLSDKKLQAENRYVQNCIDWNRDVLKKELGLDDEDIIDLPILFKVMEEKNEDSVPRAVAYYPDMVNMIVLGDQLGVPKPFGPQVKGVCALEKEMCSLLEPLGLKCTFIDDFAPYHKLLGEVHCGSNVLREPFTVRWWNLEL
InterPro domains: - IPR004303: Protein-arginine deiminase (family) [1-646]
- IPR008972: Cupredoxin (homologous_superfamily) [5-109]
- IPR013733: Protein-arginine deiminase (PAD), central domain (domain) [110-281]
- IPR013732: Protein-arginine deiminase (PAD), N-terminal (domain) [1-108]
- IPR038685: PAD, N-terminal domain superfamily (homologous_superfamily) [3-115]
- IPR036556: Protein-arginine deiminase, central domain superfamily (homologous_superfamily) [110-301]
- IPR013530: Protein-arginine deiminase, C-terminal (domain) [357-644]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016813 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Mu-type opioid receptor (B8JHS2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Endosome. Perikaryon
Sequence: MMENTGNISDLLYALSNPMVSNSSIFCRNFSNSSGLVNMNSSVCDRTPELDKSSTPVIVAIIITALYSIVCVMGLVGNVLVMYVIIRYTKMKTATNIYIFNLALADSLATSTLPFQSVNYLMGTWPFGDELCKIVMSIDYYNMFTSIFTLTTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMVMASTTSDLHSNGIIDCTLLFPHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIFVIIKALVTIPNSLLQTITWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCVPSPSVLDLQNSTRSRNPQRDGQSSGHTVDRTNQQV
InterPro domains: - IPR000105: Mu opioid receptor (family) [298-382]
- IPR001418: Opioid receptor (family) [87-342]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [62-339]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [77-331]
Interaction partners: - Pro-opiomelanocortin protein
- Proenkephalin a
- Proenkephalin-B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0042923 (neuropeptide binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Leptin receptor (A0A8M1P6L4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MMSVFIMLALLVIFIAVSQGLADLNPSDGVSDGVYEDLKWKALLCCDHPVQTLNSGLSEHPPEQHCQLLNATKQQSFGSCLDILCWLEGERENLICNAKTRRAAAASTLVSVSPHQLVVQMDVHSDEANSTAQCVGEETAICSVSLHGGDATVSLVIIISENGTTAQSQKMQVSTYELQRPGAPVNLHYNVTTEGEVIFRWTGTQPDNNTINYEIQYSSNSLLQQWKVLKVKGRSWVALNELSSDIRYTVQVRCQNHLGYWSEWSQPFYFKLDVSYIPAEVFTTQESEVTVYSVFHNRSWSASKAVWFLNGKMKIPESQYRVINEQVSTVTLKMDKAGFDTLMCCLTLGEKSMCSIAYAKIYTEGRFNANITCESEYSYVDTMICKWNQSNWAQARLLYRQYRSKCTEEAEEDTSLVKECPSKAGDHRQCTLSQISMIFCYKFWLEVEGGRGQSFPVYVTPIDYVKPSPPFDLEAITLPSKTLSVRWKRPSLPVYGMQYELQFKALAGMANTQWKVIGPLLEPQAEIQLEESCVHFKVEVRCKDVNDTGYWSDWSNSHISTVFNLKAPEMGPDFWRILQEDPTRNVTNVTLIFKQPILAGDPNSCVEGLVIKHQASGGVMWSNETTLARFHSFQWRKEAHTVTVMSRNALGISTWNRNITLLRQAKRRCVRSFSAVANVSCVHLSWSLLSDQPVPQSFVIEWLDLNKDPEKDVSLTERIQWVRVESRSRDLSLCRRFYGSEEFTLYPVFADGEGEPARYTATRGDPAAYILLLIIAFLSVVLFVTLMMSQNQMKKLMWKDVPNPNKCSWAKGMDFRQIDTMESLFPHSEGLTACPLLLVSESICEVEIIEKPHPLTIENVKDNEELPSGDKTTTDSGLQGDSSEALEASTAAPTPETSGQSSVTYSTILLSDQPSQLQKQQESLSSSSDEGNFSANNSDISGSFPGGLWDLENSNPRHSSSYNSVEEFSETSEPDYEASENTGLAKDLYYLEMTGEEKEEEEEEEEEEEEEDEPEEGQSKNKRVMGVNPRPLLESQNSTASNSNNMSHSIPLYLPQFRSECINPT
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [177-557]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [180-559]
- IPR003961: Fibronectin type III (domain) [181-564]
- IPR010457: Immunoglobulin C2-set-like, ligand-binding (domain) [277-350]
- IPR041182: Leptin receptor, immunoglobulin-like domain (domain) [369-463]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0140375 (immune receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Neuropeptide Y receptor type 2 (Q6PR57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MGQSDQVNGSEDTVLHDGNQETSLGNDSVNTYKPAFVDDITKHLSVQISLILAYSLIILLGLVGNTLVIYMIILYRNMRTVTNYFIANLALADLMVDTVCLPFTLVYTLLDEWKFGAVMCHMVPYSQALSVHVSILTLTIIALERYRCIVFHLGQRLNRCTSFIIIGLTWAFAAILAGPLAIFREYRYEEIPYIDLRIAVCSEKWPNGTNRDAVIYSLSMLLLQYVVPLAIISYAYVCIWIKLKNHVSPSNRNDGIVRRKKTTKMLALVVVVFAVCWLPFHMFQLASDLDLILKFKEYKLIYTLFHIVAMCSTFVNPLLYGWMNQNYRNGFLMFFRCEHKPDSIYPDGSFRTRSLRGMIVNGYNDGQPAAAV
InterPro domains: - IPR000611: Neuropeptide Y receptor family (family) [74-331]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [64-320]
- IPR001358: Neuropeptide Y2 receptor (family) [39-346]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [49-335]
Interaction partners: - Peptide YY-A
- Pro-neuropeptide Y
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0042923 (neuropeptide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:1902074 (response to salt), GO:0071417 (cellular response to organonitrogen compound), GO:1901699 (cellular response to nitrogen compound), GO:0042220 (response to cocaine), GO:0010243 (response to organonitrogen compound), GO:0014070 (response to organic cyclic compound), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:1902075 (cellular response to salt), GO:0043279 (response to alkaloid), GO:0071312 (cellular response to alkaloid), GO:0071407 (cellular response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: 26S proteasome regulatory subunit 6A isoform X1 (A0A0R4ILA8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
Sequence: MSSLNDRSVWDEVEDGIGEEVLKMSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENTEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNMQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVCPDVNFEELARCTDDFNGAQCKAVCVEAGMIALRRGATELNHEDYMEGILEVQAKKKANLQYYA
InterPro domains: - IPR003960: ATPase, AAA-type, conserved site (conserved_site) [314-332]
- IPR003593: AAA+ ATPase domain (domain) [207-346]
- IPR032501: Proteasomal ATPase, second OB domain (domain) [100-153]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [163-416]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [366-408]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [99-162]
- IPR003959: ATPase, AAA-type, core (domain) [211-343]
- IPR050221: 26S Proteasome Regulatory ATPase (family) [25-420]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001824 (blastocyst development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm)
Protein: Intelectin 2 (C1IHV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MGMAAFLTKMLLGFLFSVTLSLWFCEAKSMGAMYVIQETETPCINISDSNSNHELEKLLDRIKYIARSCKEIRDKYHVYEDGLYYLISSRGVLYQTFCDMTTAGGGWTLVASVHENNMYGKCTVGDRWSSEQGSNANRPEGEGTWANKVTFGAAEAATSDDYKNPGYFEIAAQDVSVWHVPNNMELEHWSTGSILRYHTENRFLTLHGGNLFSLFKKFPVRFGIGVCNTNNGPAAPIVYDTGNVDSTKTLYGPSTRSQFEPGFITFRVFNTEKAAMALCSGVKPIGCHTEYFCIGGGGHFPEGVPKQCGDFTGFDWNGYGTNTGNSASREIIEAAVLLFYR
InterPro domains: - IPR036056: Fibrinogen-like, C-terminal (homologous_superfamily) [61-266]
- IPR014716: Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 (homologous_superfamily) [58-138]
Interaction partners: - Cytochrome b5 domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0030246 (carbohydrate binding), GO:0005539 (glycosaminoglycan binding), GO:0042834 (peptidoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0098542 (defense response to other organism), GO:0019730 (antimicrobial humoral response), GO:0042742 (defense response to bacterium), GO:0019731 (antibacterial humoral response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)