Protein: Actin cytoskeleton-regulatory complex protein END3 (Q5AJ82)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Note=Cytoplasmic and cortical actin patches
Sequence: MPRLEESEIKKYWQIFQSLKPQNNKLTGDQLSSILKNSQLPQQQLSAIWELSDIDNDGKLDFEEFCIIMRLIFDVINGKLPNVPQELPSWLIPASKSAIIQANKAVNQGNNNFGDIDDDEDDKLSNDFDWYISPTDKSIYEKIYDSKCDSFGRIKYSSLNELYNGLTNVPSSEISSAWNLINPKSFETIDKDQTLVFLHILNQRENGKRIPRGVPASLRATFSKEVPNYDLSAQAKPSISATTETGKKSFAENYLNKIGGGVGASSTINNGRNEKGTDFSATQGTDWEEVRLRRELQDLERLLDKVQNDTKNQKDNSNNNQDNNDMLIKYEFEQLLKYKQNQLNSTTNASKNSTDLSSVKQDIEEIQNQVNTLQEFLTTKNQELLKLNQQIESLK
InterPro domains: - IPR000261: EH domain (domain) [1-225]
- IPR011992: EF-hand domain pair (homologous_superfamily) [4-222]
- IPR025604: Actin cytoskeleton-regulatory complex protein End3 (family) [274-388]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [53-65]
- IPR002048: EF-hand domain (domain) [40-75]
Interaction partners: - Actin cytoskeleton-regulatory complex protein PAN1
- Actin cytoskeleton-regulatory complex protein SLA1
- Sla2p
- Clathrin light chain
- Actin
- Clathrin heavy chain
- Actin-binding protein
- Actin-regulating kinase PRK1
- Epsin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0040007 (growth), GO:0009987 (cellular process), GO:0030447 (filamentous growth), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0016043 (cellular component organization), GO:0030448 (hyphal growth), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0031505 (fungal-type cell wall organization), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0061645 (endocytic patch), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0030479 (actin cortical patch), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030864 (cortical actin cytoskeleton), GO:0015629 (actin cytoskeleton)