Protein: GATOR2 complex protein WDR59 (B7Z7V6)
Organism: Homo sapiens (Human)
Function: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex
Subcellular location: Lysosome membrane
Sequence: MSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRVDSQMQRLCANDILDGVDEFIESISLLPEPEKTLHTEDTDHQHTASHGEEEALKEDPPRNLLEERKSDQLGLPQTLQQEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVKFPAQYPNNAAPSFQFINPTTITSTMKAKLLKVGVWVPKFSLLFCIIV
InterPro domains: - IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [100-295]
- IPR006575: RWD domain (domain) [372-458]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [7-296]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [7-344]
- IPR001680: WD40 repeat (repeat) [20-294]
- IPR049567: GATOR complex protein WDR59-like (family) [1-442]
- IPR019775: WD40 repeat, conserved site (conserved_site) [100-114]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0009892 (negative regulation of metabolic process), GO:0009894 (regulation of catabolic process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0010506 (regulation of autophagy), GO:1902533 (positive regulation of intracellular signal transduction), GO:0010507 (negative regulation of autophagy), GO:0031329 (regulation of cellular catabolic process), GO:0033993 (response to lipid), GO:0031330 (negative regulation of cellular catabolic process), GO:0010506 (regulation of autophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)