Protein: Poxin (Q01225)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
Function: Nuclease that is responsible for viral evasion of host cGAS- STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host cGAS following recognition of cytosolic DNA and blocks the subsequent 2',3'-cGAMP-mediated activation of TMEM173/STING, which normally spreads to adjacent cells and activates the interferon and NF- kappa-B immune responses
Sequence: MAMFYAHALGGYDENLHAFPGISSTVANDVRKYSVVSVYNNKYDIVKDKYMWCYSQVNKRYIGALLPMFECNEYLQIGDPIHDQEGNQISIITYRHKNYYALSGIGYESLDLCLEGVGIHHHVLETGNAVYGKVQHDYSTIKEKAKEMNALSPGPIIDYHVWIGDCICQVTAVDVHGKEIMRMRFKKGAVLPIPNLVKVKLGENDTENLSSTISAAPSR
InterPro domains: - IPR006853: Poxin, virus (family) [1-194]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0004518 (nuclease activity), GO:0030551 (cyclic nucleotide binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0019001 (guanyl nucleotide binding), GO:0032559 (adenyl ribonucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0044068 (modulation by symbiont of host cellular process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0035821 (modulation of process of another organism), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075528 (modulation by virus of host immune response), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0075136 (response to host), GO:0039503 (suppression by virus of host innate immune response), GO:0019054 (modulation by virus of host cellular process), GO:0031348 (negative regulation of defense response), GO:0044414 (suppression of host defenses by symbiont), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0052031 (modulation by symbiont of host defense response), GO:0019049 (mitigation of host antiviral defense response), GO:0052170 (suppression by symbiont of host innate immune response), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response), GO:0052562 (suppression by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part), GO:0033647 (host intracellular organelle), GO:0044165 (host cell endoplasmic reticulum), GO:0033648 (host intracellular membrane-bounded organelle)