Protein: Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1) (Q8K0T4)
Organism: Mus musculus (Mouse)
Function: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. Has microtubule-severing activity in vitro (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm {ECO:0000250|UniProtKB:Q9BW62}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9BW62}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BW62}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (PubMed:22654668). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity). {ECO:0000250|UniProtKB:Q9BW62, ECO:0000269|PubMed:22654668}.
Sequence: MNLAEICENAKKGREYALLGNYDSSMVYYQGVIQQIQRHCQSLRDPATKAKWQQVRQELLEEYEQVKSIVSTLESFKMDKPPDFPVSCRDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKDVGAGARGLVGRAHQISKSDKPASRDKDYRARGRDDKARKNVQDGASDSEIPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKISLREVELDPDVHLEDIADKTEGYSGADITNICRDASLMAMRRRINGLSPEEIRALSKEELQMPVTRGDLELALKKIAKSVSAADLEKYEKWMVEFGSA
InterPro domains: - IPR003593: AAA+ ATPase domain (domain) [238-380]
- IPR028596: Katanin p60 subunit A1 (family) [4-488]
- IPR028594: Katanin p60 subunit A-like 1, chordates (family) [1-488]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [400-442]
- IPR003959: ATPase, AAA-type, core (domain) [242-378]
- IPR048612: Katanin p60 ATPase-containing subunit A1, AAA domain (domain) [207-376]
- IPR015415: Spastin/Vps4, C-terminal (domain) [447-486]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [200-482]
- IPR048611: Katanin p60 ATPase-containing subunit A1, MIT domain (domain) [4-72]
- IPR050304: Microtubule-severing AAA ATPase (family) [21-487]
- IPR003960: ATPase, AAA-type, conserved site (conserved_site) [350-369]
Interaction partners: - Katanin p80 WD40 repeat-containing subunit B1
- KATNB1-like protein 1
- Katanin p60 ATPase-containing subunit A1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0044877 (protein-containing complex binding), GO:0016887 (ATP hydrolysis activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0070840 (dynein complex binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006996 (organelle organization), GO:0051013 (microtubule severing), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet), GO:0005856 (cytoskeleton), GO:0005634 (nucleus), GO:0030424 (axon), GO:0015630 (microtubule cytoskeleton)