Protein: Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Acid sphingomyelinase 2) (ASM-2) (Q23498)
Organism: Caenorhabditis elegans
Function: Sphingomyelin phosphodiesterase (sphingomyelinase) that converts sphingomyelin (N-acyl-sphingoid-1-phosphocholine) to ceramide (N-acyl-sphingoid base) and phosphocholine at acidic pH. Displays its enzymatic activity when secreted. May play distinct roles in signaling.
Subcellular location: Secreted {ECO:0000269|PubMed:9603947}. Note=Only the secreted form is enzymatically active. {ECO:0000269|PubMed:9603947}.
Sequence: MQQPLIILGIGIVLALVSNVESGVLRKPVDEHEYEKWTNARGNEAAVPPPKYKMLRYAKKAINEPENRKMSCLFCTFAVDGVQALIAQNSTDNEIAAFLVNLCDLFDVEQPHVCKNIIYAFKDEVVFVLERSVFTPEEICGAFIANCGHSDKPLTHMWNITIPGGKPPIKPWPKIPDNKPTFKVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLKDKPIYVPAGPWGMPYLCDLPYQTFESAMKHISKTFKDLDYIIITGDFEAHDSWDYTEDLTRENMNNMTNVFLEYFPGVPVYVSIGNHEGVPQDAMAPHTMPEYDTRGPQWLYKIMSEMWSHWIPQEALDTVQYRASYAVYPKPGLKLISLNTIYCSEFNFYLYVNEVDPDATLEWLIEELQDSENKGELVHIISHIPPGDNYCLKGWSWNFFEIVKRYENTIAQMFYGHTHYDQFMVYYDMDDPNRRPFHFNWISPSLTTYDWLNPAYRIYEIDGGYEGATYTVKDAKTYFANVTEANMKNKEPEWVLSYDTREHYQMADFSPQSWSDLSDKLWTNTTLFRDYVRLYYRNHYNNECYTDYKCRYTFVCDIKKGRSYDESFCDHLTK
InterPro domains: - IPR008139: Saposin B type domain (domain) [68-151]
- IPR045473: Sphingomyelin phosphodiesterase, C-terminal domain (domain) [497-604]
- IPR041805: Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain (domain) [184-501]
- IPR011160: Sphingomyelin phosphodiesterase (family) [1-618]
- IPR007856: Saposin-like type B, region 1 (domain) [71-106]
- IPR004843: Calcineurin-like, phosphoesterase domain (domain) [182-464]
- IPR011001: Saposin-like (homologous_superfamily) [69-149]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [179-543]
Interaction partners: - Acid ceramidase
- Ceramide glucosyltransferase 1
- Ceramide glucosyltransferase 2
- Ceramide synthase hyl-2
- Phosphatidylcholine:ceramide cholinephosphotransferase 1
- Probable acid ceramidase
- Putative neutral sphingomyelinase
- Putative sphingomyelin phosphodiesterase asm-3
- Putative phosphatidylcholine:ceramide cholinephosphotransferase 3
- Phosphatidylcholine:ceramide cholinephosphotransferase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004620 (phospholipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)