Protein: Ras-related protein Rac1 (P40792)
Organism: Drosophila melanogaster (Fruit fly)
Function: During various developmental processes, regulates changes in cell morphology in response to extracellular signals. During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE-cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion between the leader border cells and nurse cells further promotes Rac1 signaling creating a positive feedback loop that amplifies the output of RTK activity and leads to higher Rac activity at the front, thus promoting polarization of the border cell cluster and directionally persistent migration. Involved in axon outgrowth and myoblast fusion. Plays a role in regulating dorsal closure during embryogenesis. Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Sequence: MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGTKLDLRDDKNTIEKLRDKKLAPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRSVLCPVLQPKSKRKCALL
InterPro domains: - IPR001806: Small GTPase (family) [1-192]
- IPR003578: Small GTPase Rho (family) [3-189]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-181]
- IPR005225: Small GTP-binding domain (domain) [1-157]
Interaction partners: - non-specific serine/threonine protein kinase
- Mitogen-activated protein kinase kinase kinase
- Stress-activated protein kinase JNK
- Myoblast city, isoform B
- LD29223p
- Rho GDP-dissociation inhibitor 3
- Ras-like GTP-binding protein Rho1
- Protein vav
- Trio, isoform A
- non-specific serine/threonine protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0019901 (protein kinase binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0040007 (growth), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042440 (pigment metabolic process), GO:0006955 (immune response), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0019748 (secondary metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0019098 (reproductive behavior), GO:0016049 (cell growth), GO:0016203 (muscle attachment), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0009607 (response to biotic stimulus), GO:0006949 (syncytium formation), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0140253 (cell-cell fusion), GO:0002252 (immune effector process), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0009826 (unidimensional cell growth), GO:0048513 (animal organ development), GO:0007631 (feeding behavior), GO:0010883 (regulation of lipid storage), GO:0006725 (cellular aromatic compound metabolic process), GO:0035010 (encapsulation of foreign target), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0002433 (immune response-regulating cell surface receptor signaling pathway involved in phagocytosis), GO:0000768 (syncytium formation by plasma membrane fusion), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0051128 (regulation of cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0006582 (melanin metabolic process), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0002764 (immune response-regulating signaling pathway), GO:1901615 (organic hydroxy compound metabolic process), GO:0002118 (aggressive behavior), GO:0035556 (intracellular signal transduction), GO:0007617 (mating behavior), GO:0006952 (defense response), GO:0030036 (actin cytoskeleton organization), GO:1903036 (positive regulation of response to wounding), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0061061 (muscle structure development), GO:0048598 (embryonic morphogenesis), GO:0050776 (regulation of immune response), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0046843 (dorsal appendage formation), GO:0033554 (cellular response to stress), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0007306 (egg chorion assembly), GO:1903391 (regulation of adherens junction organization), GO:0030030 (cell projection organization), GO:0007520 (myoblast fusion), GO:0000165 (MAPK cascade), GO:0048732 (gland development), GO:0002009 (morphogenesis of an epithelium), GO:0035272 (exocrine system development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0018958 (phenol-containing compound metabolic process), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0022607 (cellular component assembly), GO:0035006 (melanization defense response), GO:0048568 (embryonic organ development), GO:0042692 (muscle cell differentiation), GO:0045995 (regulation of embryonic development), GO:0090303 (positive regulation of wound healing), GO:0007264 (small GTPase mediated signal transduction), GO:0035011 (melanotic encapsulation of foreign target), GO:0007015 (actin filament organization), GO:0030097 (hemopoiesis), GO:0022604 (regulation of cell morphogenesis), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0008258 (head involution), GO:0031532 (actin cytoskeleton reorganization), GO:0045229 (external encapsulating structure organization), GO:0001667 (ameboidal-type cell migration), GO:0050770 (regulation of axonogenesis), GO:0042742 (defense response to bacterium), GO:0016192 (vesicle-mediated transport), GO:0007390 (germ-band shortening), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0022612 (gland morphogenesis), GO:0097435 (supramolecular fiber organization), GO:0035099 (hemocyte migration), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060541 (respiratory system development), GO:0006909 (phagocytosis), GO:0008078 (mesodermal cell migration), GO:0051403 (stress-activated MAPK cascade), GO:0035162 (embryonic hemopoiesis), GO:0007424 (open tracheal system development), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0051017 (actin filament bundle assembly), GO:0007391 (dorsal closure), GO:0061041 (regulation of wound healing), GO:0008360 (regulation of cell shape), GO:0007431 (salivary gland development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0060538 (skeletal muscle organ development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007435 (salivary gland morphogenesis), GO:0016476 (regulation of embryonic cell shape), GO:0051146 (striated muscle cell differentiation), GO:0061572 (actin filament bundle organization), GO:0014902 (myotube differentiation), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0010975 (regulation of neuron projection development), GO:0007254 (JNK cascade), GO:0007266 (Rho protein signal transduction), GO:0097581 (lamellipodium organization), GO:0030032 (lamellipodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0045179 (apical cortex), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0005911 (cell-cell junction), GO:0099738 (cell cortex region), GO:0044291 (cell-cell contact zone)