Protein: Guanine nucleotide-binding protein alpha-3 subunit (Q54KV6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-3 plays a role in development. G alpha-3 mutants fail to aggregate
Sequence: MDFNPVPPPRETLRAYLSKKGHVVKNWKLRLFVLKPGSSYMEYFVDETKEQQHLPQGRVPLYGTRVMEYVYNSNNNPREFCLSVETENKNWIISTGSKAQQLEWIEAIKHAIESAVETDEIKLQKHKSIEKQLQLDGKNKNKIPVLKLLLLGTGESGKSTVVKQMKILHHKGFSKEEEEFYRNLIYINLLDGMALLIHVIKENNIEIPQETLSAIKNYSSWYRVYIEKRNKNGIRNNPIGSMIPISILNNNKDNNNSNSSSLKNNSGGSSSSELDKKMTHLSLDGSTCINSNSASPNGPSSSTTTSTINTHNRSNSDGSSNNIFNVQDFGIPPIITNYISTIWSDPVVQSEVMLQAQKYHINESTQYYLNEIKRIGKPTYQPVNLDILKSRATTNGVVETDFNVNGEVIFRIVDVAGQRGERKKWINFFDDVTAIVFVAAINEYDQKLVEDNCTNRLHESLNLFDSICNDSTFPKTSIILFLNKIDLFREKLKRTSINICFPDYNGDQSYEKSSNYIKNNFLSKKKGGNGINSQNFIYFHFTCATDTKSFETVFNSVRDIIISKTLEFYC
InterPro domains: - IPR011993: PH-like domain superfamily (homologous_superfamily) [10-119]
- IPR011025: G protein alpha subunit, helical insertion (homologous_superfamily) [173-393]
- IPR001849: Pleckstrin homology domain (domain) [10-115]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [146-566]
- IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit (family) [118-570]
Interaction partners: - Latrophilin receptor-like protein A
- Guanine nucleotide-binding protein subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0050790 (regulation of catalytic activity), GO:0060176 (regulation of aggregation involved in sorocarp development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0051338 (regulation of transferase activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0010468 (regulation of gene expression), GO:0032104 (regulation of response to extracellular stimulus), GO:0043549 (regulation of kinase activity), GO:0032107 (regulation of response to nutrient levels), GO:0051348 (negative regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033673 (negative regulation of kinase activity), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity), GO:2000479 (regulation of cAMP-dependent protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005938 (cell cortex), GO:0005886 (plasma membrane)