Protein: Ribonuclease P/MRP subunit p21 (TRIM39-RPP21 readthrough) (A0A096LP39)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEAAHCVLAQDPENQALARFYCYTERTIAKRLVLRRDPSVKRTLCRGCSSLLVPGLTCTQRQRRCRGQRWTVQTCLTCQRSQRFLNDPGHLLWGDRPEAQLGSQADSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ
InterPro domains: - IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [44-53]
- IPR050143: Tripartite motif-containing (family) [24-369]
- IPR000315: B-box-type zinc finger (domain) [102-143]
- IPR006574: SPRY-associated (domain) [306-359]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [299-372]
- IPR003879: Butyrophylin-like, SPRY domain (domain) [305-369]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [9-89]
- IPR001870: B30.2/SPRY domain (domain) [289-503]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [297-376]
- IPR007175: Ribonuclease P subunit, Rpr2/Snm1/Rpp21 (family) [369-445]
- IPR001841: Zinc finger, RING-type (domain) [29-70]
Interaction partners: - cGMP-dependent protein kinase 1
- Gamma-butyrobetaine dioxygenase
- E3 ubiquitin-protein ligase TRIM39
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0048525 (negative regulation of viral process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0060759 (regulation of response to cytokine stimulus), GO:0050777 (negative regulation of immune response), GO:0009968 (negative regulation of signal transduction), GO:0032103 (positive regulation of response to external stimulus), GO:0045069 (regulation of viral genome replication), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:0002218 (activation of innate immune response), GO:0031348 (negative regulation of defense response), GO:0009894 (regulation of catabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0031349 (positive regulation of defense response), GO:0009615 (response to virus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0030522 (intracellular receptor signaling pathway), GO:0045071 (negative regulation of viral genome replication), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:1903900 (regulation of viral life cycle), GO:0002757 (immune response-activating signaling pathway), GO:0010646 (regulation of cell communication), GO:0002833 (positive regulation of response to biotic stimulus), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0001818 (negative regulation of cytokine production), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0009896 (positive regulation of catabolic process), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0043412 (macromolecule modification), GO:0140374 (antiviral innate immune response), GO:0002753 (cytosolic pattern recognition receptor signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0001960 (negative regulation of cytokine-mediated signaling pathway), GO:1903556 (negative regulation of tumor necrosis factor superfamily cytokine production), GO:0010629 (negative regulation of gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0045088 (regulation of innate immune response), GO:0051607 (defense response to virus), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0010506 (regulation of autophagy), GO:1902532 (negative regulation of intracellular signal transduction), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:0140546 (defense response to symbiont), GO:0032481 (positive regulation of type I interferon production), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0042981 (regulation of apoptotic process), GO:0030162 (regulation of proteolysis), GO:0002221 (pattern recognition receptor signaling pathway), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0044790 (suppression of viral release by host), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0023051 (regulation of signaling), GO:0032648 (regulation of interferon-beta production), GO:0070647 (protein modification by small protein conjugation or removal), GO:0006355 (regulation of DNA-templated transcription), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0045861 (negative regulation of proteolysis), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903321 (negative regulation of protein modification by small protein conjugation or removal), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination), GO:0070534 (protein K63-linked ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)