Protein: Activator of apoptosis harakiri (BH3-interacting domain-containing protein 3) (Neuronal death protein DP5) (O00198)
Organism: Homo sapiens (Human)
Function: Promotes apoptosis.
Subcellular location: Membrane; Single-pass membrane protein. Mitochondrion.
Sequence: MCPCPLHRGRGPPAVCACSAGRLGLRSSAAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGALPTYWPWLCAAAQVAALAAWLLGRRNL
InterPro domains: - IPR020728: Apoptosis regulator, Bcl-2, BH3 motif, conserved site (conserved_site) [33-47]
- IPR017249: Activator of apoptosis harakiri (family) [1-91]
Interaction partners: - Bcl-2-like protein 1
- Apoptosis regulator Bcl-2
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Bcl-2-like protein 2
- Bcl-2-interacting killer
- Bcl-2-related protein A1
- Transcription factor Dp family member 3
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-modifying factor
- Bcl-2-like protein 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0010941 (regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0033554 (cellular response to stress), GO:0097190 (apoptotic signaling pathway), GO:0006974 (cellular response to DNA damage stimulus), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0006915 (apoptotic process), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0072331 (signal transduction by p53 class mediator), GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator), GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)