wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: RVS161-like protein RVS162 (Q59PE4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of a cytoskeletal structure that is required for membrane curvature
Subcellular location: Cytoplasm, cytoskeleton
Sequence: MSWIGIKKAINRAGTQVMLKTGHIEQTIDKEYEFQEKRYRTMEENSIKLQKNLRLYLDSLRLLTNSQINIAESLNSFYGTNNDKRSSNISRTGSVNTGDKIQTIHEEEGEEKEEEENDNTTTTTTTTTTTITTTNTTYNYNNLIQEYYATIKQLNDSCIANLENPYNQTVLNPIARFNSYYIEINEIIKKRHNKLLDYDAMKNKLRKLIENPTTNISPSMKTNIIELNHNQYEEKLKIYNQELTEVESKYVEINNQLLIELPKLINHRISYFDPSFESFVKIQLRFFNENYHVLNQLQLKLDAQTRQDYIEGKLEDRIDDVLRKMKKLDITSGLD
InterPro domains: - IPR027267: AH/BAR domain superfamily (homologous_superfamily) [20-309]
- IPR004148: BAR domain (domain) [5-310]
- IPR046982: Bridging integrator 3/RVS161-like (family) [1-333]
Interaction partners: - Regulator of cytoskeleton and endocytosis RVS167
- SH3 domain-containing protein
- SH3 domain-containing protein
- Fav1p
- Clathrin heavy chain
- Abp1p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0016043 (cellular component organization), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Sulfate anion transporter 1 (P45380)
Organism: Rattus norvegicus (Rat)
Function: Sodium-independent sulfate anion transporter. Can transport other anions including thiosulfate, bicarbonate and oxalate by mediating sulfate-oxalate, sulfate-bicarbonate, sulfate-thiosulfate and oxalate-bicarbonate anion exchange
Subcellular location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein
Sequence: MDASPEPPQKGGTLVLVRRQPPVSQGLLETLKARLKKSCTCSMPCAQALVQGLFPVIRWLPQYRLKEYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVNVGIFSLLCLMVGQVVDRELQLAGFDPSQDSLGPGNNDSTLNNTATLTVGLQDCGRDCHAIRIATALTLMAGLYQVLMGILRLGFVSTYLSQPLLDGFAMGASVTILTSQAKHLLGVRIPRHQGLGMVIHTWLSLLQNVGQANLCDVVTSAVCLAVLLTAKELSDRYRHYLKVPVPTELLVIVVATIASHFGQLHTRFGSSVAGNIPTGFVAPQIPDPKIMWSVALDAMSLALVGSAFSISLAEMFARSHGYSVSANQELLAVGCCNVLPAFFHCFATSAALSKTLVKIATGCQTQLSSVVSAAVVLLVLLVLAPLFHDLQRCVLACIIVVSLRGALRKVKDLPQLWRLSPADALVWVATAATCVLVSIEAGLLAGVFFSLLSLAGRTQRPRAALLARIGDSTFYEDAAEFEGLLPPPEVRVFRFTGPLYYANKDFFLRSLYSLTGLDAGYSATRKDRGTEVGVSNRSLVDRKDLGSVSSGDGLVVPLAFGFHTVVIDCAPLLFLDVAGMATLKDLRKNYRALDITLLLACCSPSVRDTLRKGGFLGEDQGTAEELLFPSVHSAVETACARREELMAADSAL
InterPro domains: - IPR036513: STAS domain superfamily (homologous_superfamily) [511-692]
- IPR002645: STAS domain (domain) [539-689]
- IPR011547: SLC26A/SulP transporter domain (domain) [69-481]
- IPR001902: SLC26A/SulP transporter (family) [31-695]
- IPR018045: Sulphate anion transporter, conserved site (conserved_site) [98-119]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901682 (sulfur compound transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015116 (sulfate transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0072348 (sulfur compound transport), GO:0015698 (inorganic anion transport), GO:0071705 (nitrogen compound transport), GO:0008272 (sulfate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Sulfate transporter (Q9BEG8)
Organism: Bos taurus (Bovine)
Function: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development. Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein
Sequence: MSLKNEDQNDLSPKDSVKGNDQYRAPSGIHLEPEEESRNDFWQFEPSNLFRHPRIHLEPQEKSDNNFKKFVIKKLEKSCQCSSTKAKNTIFGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPIYGLYTSFFASLIYFILGTSRHISVGIFGILCLMIGEVVDRELYIAGYDTVHAASNESSLVNQISDKTCDRSCYAIIVGSTVTFVAGVYQVAMGFFQVGFVSVYLSDALLGGFVTGASFTILTSQVKYLLGLSLPRSAGVGSLITTWLHVFRNIRKTNICDLITSLLCLLVLLPTKELNERFKSKLKAPIPVELFVIVAATLASHFGKLNEKYGTSIAGHIPTGFMPPKAPDWNLIPRVAVDAIAIAIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCQTQVSGVMTALVLLLVLLVIAPLFFSLQKSVLGVITIVNLRGALCKFKDLPQMWRISRMDTVIWFVTMLSSALISTEIGLLTGVCFSMFCVILRTQKPKASLLGLVEDSEVFESMSAYKNLQAKSGIKIFRFVAPLYYVNKEYFKSVLYKKTLNPVLVKAAQRKAAKRKIKRETVTPSGIQDEVSVQLSHDPLEFHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAVGIQVLLAQCNPSVRDSLARGEYCKKDEENLLFYSIYEAMTFAEDSQNQKERHIPNGPNFSSD
InterPro domains: - IPR036513: STAS domain superfamily (homologous_superfamily) [543-718]
- IPR002645: STAS domain (domain) [563-714]
- IPR011547: SLC26A/SulP transporter domain (domain) [110-513]
- IPR001902: SLC26A/SulP transporter (family) [74-720]
- IPR018045: Sulphate anion transporter, conserved site (conserved_site) [138-159]
Interaction partners: - HMG-box containing 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901682 (sulfur compound transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015116 (sulfate transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0072348 (sulfur compound transport), GO:0071705 (nitrogen compound transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0008272 (sulfate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: UDP-N-acetylglucosamine transporter (Q8R1T4)
Organism: Mus musculus (Mouse)
Function: Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP. May supply UDP-GlcNAc as substrate for Golgi- resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (By similarity). However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (By similarity)
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence: MSANLKYLSLGILVFQTTSLVLTMRYSRTLKEEGPRYLSSTAVVVAEFLKIMACIFLVYKDSKCSVRALNRVLHDEILNKPMETLKLAIPSGIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVSMLGKKLGVYQWLSLVILMAGVAFVQWPSDSQELNSKDLSTGSQFVGLMAVLTACFSSGFAGVYFEKILKETKQSVWIRNIQLGFFGSIFGLMGVYVYDGELVSKNGFFQGYNQLTWIVVALQALGGLVIAAVIKYADNILKGFATSLSIILSTIISYFWLQDFVPTSVFFLGAILVIAATFLYGYDPKPAGNPTKA
InterPro domains: - IPR037185: Multidrug transporter EmrE superfamily (homologous_superfamily) [87-159]
- IPR007271: Nucleotide-sugar transporter (family) [2-320]
Interaction partners: - Hippocampus abundant transcript 1 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0005338 (nucleotide-sugar transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015165 (pyrimidine nucleotide-sugar transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0015780 (nucleotide-sugar transmembrane transport), GO:0006810 (transport), GO:0090481 (pyrimidine nucleotide-sugar transmembrane transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015931 (nucleobase-containing compound transport), GO:0015711 (organic anion transport), GO:1901264 (carbohydrate derivative transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Zinc transporter ZIP2 (G3X943)
Organism: Mus musculus (Mouse)
Function: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (By similarity). In the skin, aids in the differentiation of keratinocytes in the epidermis
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MEVLLGVKIGCLLALLVLTLGCGLTPIYVKWFQMDAATGHHHRVLSLLGCTSAGVFLGAGLMHMTAEALEGIESEIQKFVEQNSTGSKGNSSRDAASSYVEYPYGELVISLGFFFVFLLESLALQCCHGAAGGSTVQEEEWGGTHAFGFHKHPAVPSPSRGPLRALVLLLSLSFHSVFEGLAVGLQATVAATIQLCVAVLAHKGLVVFSVGLRLGKIGTGPRWATFCILSLALMSPVGLALGLTVAGGASGQTQGLAQAVLEGIAAGTFLYVTFLEILPRELACPEAPLAKYSCVAAGFAFMALIALWA
InterPro domains: - IPR003689: Zinc/iron permease (family) [5-306]
Interaction partners: - Zinc transporter ZIP4
- Zinc transporter ZIP11
- Zinc transporter SLC39A7
- Zinc transporter ZIP9
- Zinc transporter ZIP12
- Zinc transporter 6
- Probable ATP-dependent DNA helicase HFM1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Mitochondrial S-adenosylmethionine carrier protein (Q4V9P0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L- homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl- L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MDRREFTASLVAGGCAGMCVDLTLFPLDTIKTRLQSQQGFYKAGGFRGIYAGVPSAAIGSFPNAAAFFVTYESTKSVFSGYTTTNLAPITHMLAASLGEIVACLIRVPTEVVKQRTQANPSISTYRVLLNSLQEEGFRGLYRGYGSTVLREIPFSLVQFPLWEYLKAVWWRRQGGRLDSWQAAVCGALAGGVAAFVTTPLDVAKTWIMLAKAGTSTASGNIPMVLCEVWRSRGIPGLFAGSIPRVMFISMGGFIFLGAYEKVRRTLL
InterPro domains: - IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [5-267]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [4-266]
Interaction partners: - Solute carrier family 2, facilitated glucose transporter member 5
- THO complex subunit 7 homolog
- Cysteine desulfurase
- Large ribosomal subunit protein mL63
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901682 (sulfur compound transmembrane transporter activity), GO:0015101 (organic cation transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: SAYSvFN domain-containing protein 1 (Q9VBW0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Ufmylation 'reader' component of a translocation-associated quality control pathway, a mechanism that takes place when a ribosome has stalled during translation, and which is required to degrade clogged substrates. Specifically recognizes and binds ufmylated ribosomes when a ribosome has stalled, promoting the transport of stalled nascent chain to lysosomes for degradation (By similarity)
Subcellular location: Endoplasmic reticulum membrane
Sequence: MADFQEQLRQYRAQKRRKETVDNFKDKLRRFWMLGTGANKDTTIEVQQVPTKFEAISENSQDEAVTSSESELVPEEQPTRSTDHHHKENNCLKYTLWTVYLLFWITLYVIAIKLSFGLVFLMFSALFGIYFNTRTEPKKRNEMSAYSVFNKNCESIDGTLKAEQFEREIRYGSGSVR
InterPro domains: - IPR019387: SAYSvFN domain (domain) [101-169]
- IPR039159: SAYSvFN domain-containing protein 1 (family) [11-173]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007292 (female gamete generation), GO:0048477 (oogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Sodium-coupled monocarboxylate transporter 1 (Q3ZMH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide (By similarity). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (By similarity). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity)
Subcellular location: Apical cell membrane; Multi-pass membrane protein
Sequence: MPGSGGPVATFSVWDYVVFAGLILVAAGIGLFQSFRGRKEASSDEFLLGGRQMTAVPVALSLTASFMSGITVIGTPAEAYLYGTPFWLFFISYAIMSTISAEIFVPLFYRLNITSTYEYLEMRYNKLIRVIGTSMYIIQTALYTGMVIFAPALALNQITGLDLWGVLVATGAVCIIYCTLGGLKAVIWTDVFQMIIMLGGFVAVIARGAVLQGGLGRVWNDSFYGGRLETFSFDPDPLRRHSFWTIVVGGSLMWASMYSINQSQVQRYISCRTMTHAKLSLYVNMVGLWVTVSLAMMSGLTMYSIYKDCDPFTNKDVGATDQLLPYLVMDILADFPGLPGLFVAAAYSGTLSTVSSSINALVAVTVEDFMKPAWPSLTERQLSWINMGMSVFYGAVCIGMAGVASMMGNILQAALSIFGMISGPLLGLYMLGMFFRCANSTGGLAGLASGLAITLWVGIGAQLYPPLPEKTLRLPLSVEGCVALNTSETTTMTPFSTVLQTTTPQPRPALADNWYSLSYLYFSPVGIVVTMIIALIVSAISGGCKQKKVRPELFISKSDLICFRCKKSDSEVSDLIETKPKDNQGLDSPVFYDNEIVLKEKDQQEKITKL
InterPro domains: - IPR038377: Sodium/glucose symporter superfamily (homologous_superfamily) [40-561]
- IPR041992: SMCT1, solute-binding domain (domain) [8-547]
- IPR051163: Sodium:Solute Symporter (SSF) (family) [9-563]
- IPR001734: Sodium/solute symporter (family) [12-464]
Interaction partners: - Neutral amino acid uniporter 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Sodium-coupled monocarboxylate transporter 2 (Q7T384)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Acts as an electroneutral and low-affinity sodium (Na(+))- dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate
Subcellular location: Apical cell membrane; Multi-pass membrane protein
Sequence: METVGRFQAGDYVVFACLFVVSSGIGVFFAIKERNKAPSKEFLVGGRQMSCGPVALSLTASFMSAVTVIGAPADVYRFGASYVIFGVAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCKLVRVAATLIYIIQTILYTGVVVYAPALALNQVTGFDLWGSIFATGIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSSRAGGIENVWSTSRTGGRLQVFDFDVSPLRRHTFWTLSVGGTFTWLGIYGVNQSTIQRCISCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLISAPDQLMPYFVMEILGAFPGLPGLFVACAFSGTLSTVAASINALATVMYEDFVSQCFPDLSNRAASWISKALCVAFGVACTTMAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGGLIVGISLSFWVGVGAFIYPAPSNNTHALELNTAGCNITAAAFEPTSATVTQLTSDRNWLADSWYSMSYLYYSAVGFIGTVAAGLLITLLTGPMDPKLLKPGMTRSVKEVMCFCTEKFTEADLGEGKEDVGDFGKAWEKHPDQGCTLRMDEKFRCSCDNQQENGNTNAGFDHNETSIVQKKL
InterPro domains: - IPR042700: Sodium-coupled monocarboxylate transporter 2, solute-binding domain (domain) [4-533]
- IPR038377: Sodium/glucose symporter superfamily (homologous_superfamily) [36-557]
- IPR051163: Sodium:Solute Symporter (SSF) (family) [4-556]
- IPR001734: Sodium/solute symporter (family) [8-460]
Interaction partners: - Solute carrier family 25 member 47-A
- Solute carrier family 22 member 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015355 (secondary active monocarboxylate transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)