Protein: Protein son of sevenless-like Protein (D2A5R8)
Organism: Tribolium castaneum (Red flour beetle)
Sequence: MNTVNAGDNFYDFTNEENSAKWKGVLTTALKRVLEQVHPSLDAREDALEYVENLCLRLLAMLCAKPSPHTVQDVEYRVQSTFPTPIDKWALKEAQGALDRGKKKSVLLLPVDKIHSLLQKELLLYKVDSTVSLFLVAVLEYISADILKLAGNYVKNIKHFEITYQDVQISMNADKALMDMFYQDEGGGPGLPTESLLVSSAPRTSLTYEEVVRELIASEKAYIKELHMLIKVFREEIIKLSSDSTEIELIFSNIMDIYELTYTLLGSLEDVIEMAQDQMSYIGSCFEELAEAAEFDVYIKYAKDVTAPTCRSTLNSLLSRPDVENALISAGQGMRLALKYYLPALLMGPIRHCFSYIEYITILRGLSVAPEDRETLTQVEGLLKPLQIELSRCVPSPAMLRSCSTPFLQVRARRQAALDKLHEIEKNVENWDPKDLGQCCNEFVREDVLMKVSSGKRLTERRVFLFDGLLILCKPNSRRQSSVHQNHAECRLKERFFIRKVEIIDHLDTEELKNAFEIAPRHMQPSVILCAKTAEEKNSWMADLVMLNTRSMLERILDSILSDIERKHPLKLPPPSLYKFAEPDSKDNIILEQRENGGVPLIKGATLYKLVERLTYHIYADPKFVRTFLTTYRSFCSPKELLDLLIERFQIPDPSLVYEQECCDTDKMQKNNQREDWKKYRKEYVQPVQFRVLNVLRHWVDHHFYDFERDPTLLVKLRDFLDAVNGKSMRKWVDSVLKILHRKMENDNQRHIRFAFDEPPPPIEWHIPCTEEEYGILTLHPVEIARQLTILEFDLYRMIKPSELVGAVWTKKDKETTSPNLLKMIKHTTNVGRWLEKNIVEAENFEERVAILNRIIEIMIVLYEINNFNGVLSIVSTCASASVHRLKLTFAALTQQNKKALEECRADDHFKKYQEKLRSINPPCVPFLGMYLTNILHIEEGNPDFLPNTQLINFFKRRKVAEITGEIQQYQNQPYCFSVESKIRHFLENLNPFGDLSDTEISNYLYNKSMEIEPRGQKQVQKFPRKWPHLSLKSPGIKSKAKTTATAVTNAINSTLNSSNIKSDDSKSEDSSKSDNEFSVFAPVQLGTCQNSPTLSPVSPATSNTILSWFQPNHNRSPSVGSIMSTTSMRNPPPPPPQASKYQHYSQSSTGGSNSPGPHSPASPGPVQSYEPNSPRRPLTPPPPPPPLPPRRRRDSPEISSPQLKTDPHWRECSPPPLPPRRGDPGSSPSSHIQHSHHSFNSFGGGTMPRLNPTHMSQLHMRRHSTVQPQVPRRTVHANVTPLVPQNQPASISPRYDSATPRLPPRPAARSADMVTGPMFQYPSTTTT
InterPro domains: - IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [776-1016]
- IPR009072: Histone-fold (homologous_superfamily) [10-181]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [417-532]
- IPR000219: Dbl homology domain (domain) [207-393]
- IPR000651: Ras-like guanine nucleotide exchange factor, N-terminal (domain) [597-744]
- IPR001849: Pleckstrin homology domain (domain) [442-551]
- IPR019804: Ras guanine-nucleotide exchange factor, conserved site (conserved_site) [925-956]
- IPR002119: Histone H2A (family) [93-203]
- IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [761-1015]
- IPR008937: Ras-like guanine nucleotide exchange factor (family) [524-1025]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [571-1040]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [442-544]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [206-402]
Interaction partners: - Protein enhancer of sevenless 2B-like Protein
- SHC-transforming protein 2-like Protein
- Ras-like protein 1
- Receptor protein-tyrosine kinase
- Tyrosine-protein phosphatase non-receptor type
- non-specific protein-tyrosine kinase
- Adapter molecule Crk-like Protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0050794 (regulation of cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0051057 (positive regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm)