Protein: Nuclear factor of activated T-cells 5, tonicity-responsive (Nuclear factor of activated T-cells 5a) (Q6PD88)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MPSDFISLLSADIDPSSPKSLYSKESVYDLLPAELQLPSLVQQENSSMSQKSGGEAGPPPAAAAAALPTDAAAPCAAASSPGALSSTLPSCPSMLSATSAPEQTPEPQPERMEPASDAAQSQATPSKRRTVLSISPPPEDLLDDSRMSCQDDTLPNLDSEQSSTIWLEDSVSNFSMGSSSSYNDNTEVPRKSRKRTPRQRPGSKPAAREEAGMDVFDADSAKAPHFVLSQLGSDAKVTPKASSLEVSNNQKGGVLSIQYPPKSEGKELKILVQPETQHRARYLTEGSRGSVKDRTQQGFPTIKLDGVSDPVVLQVFVANDAGRVKPHGFYQACRVTGRNTTACKEVDIEGTTVIEVNLEPTNSMTLPVDCVGILKLRNADVEARIGVAGSKKKSTRARLAFRVNIPRPDGSILTLQTLSSPILCTQPAGVPEILKKSLHSGSVAGGEEVFIIGKNFLKGTKVLFQENSSDESGWQAEAEIDMELFHQNHLVVKVPPYHDQTVANPVSVGIAVVTNAGRTHDLQTFTYTPLTEKVEIPVKSELPATVKACTFEEQIKAMQTETSCLNNVIMLPMVKREEPMEVSCNATPSDIFKPVETLSSTQQILEISTVLPSATKSFPSPVALQPVDSQQAPAQIFTTQETLATIQKQDIPSPASFQVSLSEDTTVLQPVPPQVPQQSLRETPETLSPEDSSADGAGMVLVGIDRNPPSQRQQVQALLPQDGVAQLELAVRELQAQQQLNSVLYSPTPSAESLQQHVQENMNSLRLGGNETTLTNQQQQQQEQNILENLQQQQQKALVDLQHQQTVLENLQQHQKVLENLQQHAMGNIQQQQTHKVLENLQHQQQHQRVLENIQQQSSIVTLQHQKVLDNLQQQQQHQINLETLQHQEVLESLKQQLQSELMQTQIPMQCTPSFTNDQQSSTQASTLPQSSDGFLQNPPQQQAALFQQTGGIMTIQTSGFLQQPSAQPSPPQPLFQSHNPLTETQDTQAVLFGATKPPQVQAALFPSTMTMLTSSNLPTEQQPPSASLFIAQSVLPASDNTQNQPPQQITFLTPMQTSGAEPQTVSLFQGQTQLSTPMEQQQSPQQQQMPTSQQAPLFSNITTISPNQAQQPTQTGILFCTTTINPHDLPQALLFSGQNQASLGTDRLPENIFQEQQPMQVVPSSENVSSNNPSNQPAVPAAQAAQNPSIIFTQTGVVNVAQQDSAEPMSFQDQSTGVNESSASLPSTRTELFQDQQPMQVVPSAASVTPVSPSDQPSVNIYLPPSAISALQGGVSAQDLPPAAAAATMFSGQTGVSGLQNAAPTAPPQPSSQLFQTAIGGTLSQPGPPGPAGLFLFEIPSDCGTLINSPGPPLSDQLVTLGHPGADQNQTQLQTNAQIQTLLDPSSNLEDKIDQLLESFQEQGKSLPQDFLDH
InterPro domains: - IPR002909: IPT domain (domain) [430-528]
- IPR008366: Nuclear factor of activated T cells (NFAT) (family) [15-884]
- IPR015646: Nuclear factor of activated T-cells 5, Rel homology domain, DNA-binding domain (domain) [266-426]
- IPR037059: Rel homology domain (RHD), DNA-binding domain superfamily (homologous_superfamily) [255-424]
- IPR032397: Rel homology dimerisation domain (domain) [432-530]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [258-430]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [425-529]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [429-537]
- IPR011539: Rel homology domain, DNA-binding domain (domain) [255-429]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0050794 (regulation of cellular process), GO:0006970 (response to osmotic stress), GO:0010941 (regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)