Protein: Integrin alpha-4 (A0A0R4ICS1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence: MISSQLTGDLLKWTSGFGILWYLLILCDCYNLDVEHPLVFNGPNGSLFGYSVLLHQHNENTWLLVGAPVANSSFYPNIKSPGAIYNCSMLNSQCEQLPVGGVQRCGRHCLAENDNQWLGVSLSRQASKGHVLACGHRWKNVFYSSKDNQNKLPHGVCFRFSPDLKHASHIIPCYKDHQRRFGEGYGSCQAGISNSFTEDLMVMGAPGTSYWTGSVLVVNTTSNISAAYVDDDSDVLYGSYLGYSVSAGHFLDPQSTEIVGGAPQHEQTGKAYIFRIEGNTLKIVNKTKGKTLGSYYGASVCAVDLNADGLSDLLVGAPMFSSVREEGRVYVYINQGEAELKEADFELVGSDSYAARFGETIINLGDIDDDGYPDVAIGAPQEDDLRGAIYIYNGRRSGIARSFSQRITGSLLGNNFRMFGQSVSGGVDIDSNNYPDVAVGAFLSDSAVVFRTRPVVKVDAVMLLPESLNRSVAQCTENGQPAVCIKVRVCFRVRGKQIPGNIELKYNLTADVHHKEGFPSRFYFSGNGTSNVTAGRVKAKHEQLTCVFHQAFMKKDVRDIFTPIHFEVKYELGEHRVVQRDLGDLPALKPILQQKDELDNVIKNKTIFARYCSWENCSTNLQVSARLVLPQSYNKMPYFALGNGKSIMLNTTLLNTGDDAFLPKLHLRFPSNLHFIKVLEEDKLVSCEIVEENKLAIGLDCSVGNLYMPPFSKLNITFLLDVMQNSSAGDLTVNINATSENFENADLQHDNVAALTLPLRYAVDMNVHGFVSPNLFIIGEEESVPVDCYPEKFNYTYKVMNIGPSKARDARVKISLPLMLVLYKHQLIRITDIQSTLGHCFQRNNTIHIIDDCDVPEASVIQELVFFFSPKSKRIMFCGPEDQTCRTVECRFGDLEAGKEVTINMEVELNPRVLQMSPGRHAVMMIHGSIDLISPVRDANTFLLQDDVSARVMVEALYTHNPGPVVRIFIIVSSLIVGLIIFGLLVLTLWKLGFFKRTLKEKFRRDSWDYVPKHESVS
InterPro domains: - IPR000413: Integrin alpha chain (family) [238-997]
- IPR013519: Integrin alpha beta-propellor (repeat) [44-470]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [452-609]
- IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [612-753]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [791-935]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [30-455]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [454-917]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [990-997]
- IPR013517: FG-GAP repeat (repeat) [297-392]
Interaction partners: - Vascular cell adhesion molecule 1b
- Integrin beta
- Fibronectin
- Integrin beta
- Integrin beta
- Junctional adhesion molecule 2b
- Integrin beta
- Laminin subunit gamma-1
- Integrin beta
- Laminin subunit gamma-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0001968 (fibronectin binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0036303 (lymph vessel morphogenesis), GO:0001946 (lymphangiogenesis), GO:0001945 (lymph vessel development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098636 (protein complex involved in cell adhesion), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:0008305 (integrin complex), GO:0005886 (plasma membrane)