Protein: Iodotyrosine deiodinase (EC 1.21.1.1) (Halotyrosine dehalogenase) (E9FR69)
Organism: Daphnia pulex (Water flea)
Function: Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine. Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity).
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Sequence: MENYVPFLVSHWRTVGLISVSIAAGVALGQLNQTHERAANKSQRVHTNSSIKAKQVKRESAIEQINEIEDDDEQSLEDQDVLPILFQYEKPSEADSIRRSEEFYRRMNQRRSVREISSDPVALEVIENIIKTGGTSPSGAHTEPWTFVVVSNLEMKQQIRQIIEAEEEINYKQRMGDVWVQDLQPVGTTWVKEYLTEAPWLILIFKQVHGFKRNGQKKIHYYNEISVSIATGFLLAAIQEAGLVTVTTTPLNCGPSIRVLLGRPVNEKLLLLLPVGYPKVGATVPDFKRKPLHDIMVHYQ
InterPro domains: - IPR050627: Nitroreductase/BluB (family) [93-297]
- IPR000415: Nitroreductase-like (homologous_superfamily) [83-300]
- IPR029479: Nitroreductase (domain) [109-277]
Interaction partners: - NADPH-dependent FMN reductase-like domain-containing protein
- Riboflavin kinase
- 2Fe-2S ferredoxin-type domain-containing protein
- 2Fe-2S ferredoxin-type domain-containing protein
- Corrinoid adenosyltransferase MMAB
- Alpha-methylacyl-CoA racemase
- EOG090X05UC
- 4a-hydroxytetrahydrobiopterin dehydratase
- Cytochrome c oxidase subunit 3
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0016491 (oxidoreductase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:1901265 (nucleoside phosphate binding), GO:0010181 (FMN binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0042445 (hormone metabolic process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0042403 (thyroid hormone metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0006082 (organic acid metabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0018958 (phenol-containing compound metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006570 (tyrosine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)