Protein: Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ET-AR) (Q61614)
Organism: Mus musculus (Mouse)
Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [97-369]
- IPR051193: G-protein coupled endothelin receptor (family) [60-426]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [82-377]
- IPR000499: Endothelin receptor family (family) [69-304]
- IPR002175: Endothelin receptor A (family) [8-426]
Interaction partners: - Endothelin-3
- Endothelin-1
- Endothelin-2
- Angiotensinogen
- Endothelin receptor type B
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-13
- Kininogen-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048871 (multicellular organismal-level homeostasis), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0019098 (reproductive behavior), GO:0044706 (multi-multicellular organism process), GO:0019725 (cellular homeostasis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0002685 (regulation of leukocyte migration), GO:0051282 (regulation of sequestering of calcium ion), GO:0098660 (inorganic ion transmembrane transport), GO:0007588 (excretion), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0007631 (feeding behavior), GO:0060255 (regulation of macromolecule metabolic process), GO:0034764 (positive regulation of transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0045184 (establishment of protein localization), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0032103 (positive regulation of response to external stimulus), GO:0044237 (cellular metabolic process), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0071806 (protein transmembrane transport), GO:0003014 (renal system process), GO:0007631 (feeding behavior), GO:0034764 (positive regulation of transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0045184 (establishment of protein localization), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0032103 (positive regulation of response to external stimulus), GO:0007567 (parturition), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0043270 (positive regulation of monoatomic ion transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0032101 (regulation of response to external stimulus), GO:0003013 (circulatory system process), GO:0030278 (regulation of ossification), GO:0090066 (regulation of anatomical structure size), GO:0008284 (positive regulation of cell population proliferation), GO:1902074 (response to salt), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0007276 (gamete generation), GO:0045597 (positive regulation of cell differentiation), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0007617 (mating behavior), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0050920 (regulation of chemotaxis), GO:0019538 (protein metabolic process), GO:0034762 (regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0030534 (adult behavior), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0002687 (positive regulation of leukocyte migration), GO:0003012 (muscle system process), GO:0098739 (import across plasma membrane), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0009612 (response to mechanical stimulus), GO:0090183 (regulation of kidney development), GO:0050921 (positive regulation of chemotaxis), GO:0098655 (monoatomic cation transmembrane transport), GO:0045664 (regulation of neuron differentiation), GO:0097305 (response to alcohol), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0001944 (vasculature development), GO:1902075 (cellular response to salt), GO:0006936 (muscle contraction), GO:0051209 (release of sequestered calcium ion into cytosol), GO:0071702 (organic substance transport), GO:0030334 (regulation of cell migration), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:1902622 (regulation of neutrophil migration), GO:0010468 (regulation of gene expression), GO:0019932 (second-messenger-mediated signaling), GO:0045744 (negative regulation of G protein-coupled receptor signaling pathway), GO:0030501 (positive regulation of bone mineralization), GO:0051928 (positive regulation of calcium ion transport), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0002688 (regulation of leukocyte chemotaxis), GO:0051252 (regulation of RNA metabolic process), GO:0071675 (regulation of mononuclear cell migration), GO:1901701 (cellular response to oxygen-containing compound), GO:0071417 (cellular response to organonitrogen compound), GO:0003018 (vascular process in circulatory system), GO:0043278 (response to morphine), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0006508 (proteolysis), GO:0071310 (cellular response to organic substance), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:1901699 (cellular response to nitrogen compound), GO:0046903 (secretion), GO:1902624 (positive regulation of neutrophil migration), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:0035150 (regulation of tube size), GO:0043434 (response to peptide hormone), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0055080 (monoatomic cation homeostasis), GO:0050727 (regulation of inflammatory response), GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045986 (negative regulation of smooth muscle contraction), GO:0008104 (protein localization), GO:0043269 (regulation of monoatomic ion transport), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0060429 (epithelium development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)