wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Protein patched homolog 3 (H2L0G5)
Organism: Caenorhabditis elegans
Function: Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:21215260}; Multi-pass membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:21215260}. Note=Co-localizes with ajm-1, an adherens junction marker in hypodermal cells and vulval toroids. {ECO:0000269|PubMed:21215260}.
Sequence: MSFPDEETDLLSEAKHCIRNVIHRTHRKFLENRLIGNFDSEDFSDAWKKKFAHAPTWCDADMSLQQIKRGKAVGNTVALTARAFFQLWLFRIGCFVQRWAWSTIFISLFLYCLCLGGLRHVTIETDLVKLWVSEGGRLNEEMGYLGQVKFERESGHLVHKVKRAVEQTTEPPAPAVKAEVRRGPELPKENGLGGGFQVVIQTPSFDGQNILSKEALQQHTKLMEEISTYEVKMFNETWTLSDICFKPPGPSFNSGPLAGIMSKLLDKIIPCIWITPIDCYWDGAKPLGPNPPLNLGPEVASFVSSLPPGNVTWKNLNPTSVIKEVGTLFDLGPIGNFFERAGIDGAYLDRPCIDPLEEECPKSAPNYFDRCHALTKFNEWNMAKAMSEQVTLERKIIPKDDGKSDIAETILNDIFGKKRRKRQADTTTKKPATKKDEDYYEYEDDADYLAGIANSTIAKKNPEKEAKDLLCLEYGSSLLKWMQENPERLGEFLTKEEMPDYPNYGDVMTGGCKGFGKKIMEWPEDLIIGGIQRDNGKLVSAEALQSVFLVSGAYDVFARIKNDKTDSHPGLDRHHFQPWMAGEIISTWQRNFTKRLYSHELNRERRQFHPLASTSIADMLEEFSQFNYIIIVIGYILMVIYAAFTQGRFQGWWLAVQSNVALAICGVILVTISSICGLGFATHLGINFNAATTQVVPFLSLGLGIDDMFLLLHNYDEIINICNKNEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYCSRGNPQMATSQSVPSNVSNMSSRAELAGYEKQADEYKRHEPWYTVGGFLNKIYIPALKNNVVKACVLIGTTTAVVFGLYGMYTSTLGLELADVLPEHTPPAAFLRAREQYFSFYPMFAVLRGDKLDIPNQQQLIEEYRAQLGSSKFMIKAEGKLQPYWMSMLRVWLQSLDMALEKDLAAGKFDLTNGNPIKVNGEKPSPESMIAARLVCSFGTNYNCDGRLGKMKMVENEVINPEGFYNYLTGWFNVDNMMYYVSQASFYPTPPGWEYNEKLAKVVPAAEPLLYSQMPFYQNDLIDTPAIVKMIEEIRATCEEYSERGLSNHPSGIAFTFWEQYLTLRWNLFQAICIIALAVFCVISILMFNPWAATLIMCIVVITTIELGGFMGLMGIKMNPISAVTLICAVGIGVEFTAHVELAFLTALGTIDQRLESCLQHMFVPVYHGAISTFLGVVMLVFSEFDFVVTYFFYTMTLLVALGVFNGLCVLPVILTLVGPKPELTPTDGSSVLPPPPPLRQQYAEKSGGVEGGMRKRKEKRPAEVEMSARDSPSTSSASHSSDDESSPAHK
InterPro domains: - IPR053958: HMGCR/SNAP/NPC1-like, sterol-sensing domain (domain) [656-804]
- IPR000731: Sterol-sensing domain (domain) [627-788]
Interaction partners: - Frizzled-4
- Protein patched homolog 1
- BBSome complex member BBS1
- Polycystin-2
- Location of vulva defective 1
- BBSome complex member bbs-7
- BBSome complex member bbs-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0042303 (molting cycle), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0042303 (molting cycle), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: GPI-anchor transamidase (Phosphatidylinositol-glycan biosynthesis class K protein) (Q6IQM5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MDYSNLFTVYSCLLLFVSIPCAYSNYVETKAGQFFSSGHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLADDMACNYRNPKPATVFSHKNMELNVYGDDVEVDYRGYEVTVENFLRVLTGRLPLSTPRSKRLLSDDRSNILIYLTGHGGNGFLKFQDSEEISNMELADAFEQMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDLAIGVHLMDKYTFYLLEFLEEVHPASQANMNDLFKVCPQSQCVSTPGHRTDLFQRDPGSVLITDFFGSVRKVEITKDTISLTCPVESPMQRSGSGDLQVETFTYVDQLPVAEIIHQKPKQKDWHPPDGFILGLWTLILLVFFQTYGIKHLKHIF
InterPro domains: - IPR001096: Peptidase C13, legumain (family) [4-271]
- IPR028361: GPI-anchor transamidase (family) [3-389]
Interaction partners: - Phosphatidylinositol glycan anchor biosynthesis, class T.
- Phosphatidylinositol glycan anchor biosynthesis, class S.
- Glycosylphosphatidylinositol anchor attachment 1.
- Phosphatidylinositol glycan anchor biosynthesis, class U.
- GPI inositol-deacylase
- GPI ethanolamine phosphate transferase 3
- Phosphatidylinositol glycan anchor biosynthesis, class F
- GPI alpha-1,4-mannosyltransferase I, catalytic subunit
- Phosphatidylinositol glycan anchor biosynthesis, class L.
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: AlkB homolog 3, alpha-ketoglutarate dependent dioxygenase (E9PSA5)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIEEGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPE
InterPro domains: - IPR037151: Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily (homologous_superfamily) [69-223]
- IPR027450: Alpha-ketoglutarate-dependent dioxygenase AlkB-like (domain) [89-219]
- IPR032854: Alkylated DNA repair protein alkB homologue 3 (family) [21-222]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0032451 (demethylase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006304 (DNA modification), GO:0006281 (DNA repair), GO:0006307 (DNA dealkylation involved in DNA repair), GO:0035510 (DNA dealkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Tubulin polymerization-promoting protein family member 3 (TPPP/p20) (Q9BW30)
Organism: Homo sapiens (Human)
Function: Regulator of microtubule dynamic that has microtubule bundling activity. Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation of beta-catenin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:30667362}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:17105200}.
Sequence: MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [2-138]
- IPR008907: Tubulin polymerization-promoting protein (family) [6-175]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:2000241 (regulation of reproductive process), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:1901317 (regulation of flagellated sperm motility), GO:2000145 (regulation of cell motility), GO:0032886 (regulation of microtubule-based process), GO:1902019 (regulation of cilium-dependent cell motility), GO:0060632 (regulation of microtubule-based movement), GO:0060295 (regulation of cilium movement involved in cell motility), GO:0003352 (regulation of cilium movement)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Flagellin B (Flagellin N) (Q07911)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
Subcellular location: Secreted. Bacterial flagellum.
Sequence: MSFRINTNIAALTSHAVGVQNNRDLSSSLEKLSSGLRINKAADDSSGMAIADSLRSQSANLGQAIRNANDAIGMVQTADKAMDEQIKILDTIKTKAVQAAQDGQTLESRRALQSDIQRLLEELDNIANTTSFNGQQMLSGSFSNKEFQIGAYSNATVKASIGSTSSDKIGHVRMETSSFSGAGMLASAAAQNLTEVGLNFKQVNGVNDYKIETVRISTSAGTGIGALSEIINRFSNTLGVRASYNVMATGGTPVQSGTVRELTINGVEIGTVNDVHKNDADGRLTNAINSVKDRTGVEASLDIQGRINLHSIDGRAISVHAASASGQVFGGGNFAGISGTQHAVIGRLTLTRTDARDIIVSGVNFSHVGFHSAQGVAEYTVNLRAVRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAMIVMDMADSARTQLDKIRSDMGSVQMELVTTINNISVTQVNVKAAESQIRDVDFAEESANFSKYNILAQSGSFAMAQANAVQQNVLRLLQ
InterPro domains: - IPR042187: Flagellin, C-terminal domain, subdomain 2 (homologous_superfamily) [460-514]
- IPR046358: Flagellin, C-terminal domain (domain) [428-513]
- IPR010810: Flagellin hook, IN motif (conserved_site) [198-311]
- IPR001029: Flagellin, N-terminal domain (domain) [5-142]
- IPR001492: Flagellin (family) [4-514]
Interaction partners: - Flagellar secretion chaperone FliS
- Flagellar hook-associated protein 2
- Flagellar motor switch protein FliN
- Flagellar hook-associated protein 1
- Flagellin A
- 6-hydroxymethylpterin diphosphokinase MptE-like domain-containing protein
- Flagellar motor switch protein FliG
- Flagellar hook protein FlgE
- Flagellar motor switch protein FliM
- Flagellar basal body rod protein FlgB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0048870 (cell motility), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0097588 (archaeal or bacterial-type flagellum-dependent cell motility), GO:0071973 (bacterial-type flagellum-dependent cell motility), GO:0071978 (bacterial-type flagellum-dependent swarming motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0043226 (organelle), GO:0043228 (non-membrane-bounded organelle)
Protein: Fibronectin type-III domain-containing protein (A0A060WMK8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Not known
Sequence: MVGIGLAHISLIFVLCQRHVDSYVPPPVNVSLICHNFHNVIYWNYSEPSLQPQFNVEMTRKYSGAALVCSNTSLYHCDVSSFTKVIEEGYRFILTAVGQNTNSPEISFTYDDTVYSDVVVHCSLDFPPVNISAVSDQIIKVQFIHPFHIYKYAIIKNERPDHKEFHYMVVAEDPLKEHSFTCSYKQHHVCEAEIPVDGKMDRHCVKMKGKMNNVHVSAHQNICIEGKHGDSGPSYTALYIVIPIVAMVVIAFIVWLIYRXXXXXXXLCFGLPIEPELCFGLPIEPELCFGLPIEPALCFGLPIEPALCFASS
InterPro domains: - IPR050650: Type II Cytokine and Tissue Factor Receptors (family) [13-257]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [21-109]
- IPR003961: Fibronectin type III (domain) [12-103]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [21-229]
Interaction partners: - Uncharacterized protein
- Interferon/interleukin receptor domain-containing protein
- Fibronectin type-III domain-containing protein
- Fibronectin type-III domain-containing protein
- Fibronectin type-III domain-containing protein
- Interferon alpha-2-like
- Fibronectin type-III domain-containing protein
- Uncharacterized protein
- Uncharacterized protein
- Type I interferon b3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0010628 (positive regulation of gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Peroxisomal membrane protein PEX13 (Peroxin-13) (Q7JRD4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Peroxisome membrane {ECO:0000256|ARBA:ARBA00046271}.
Sequence: MVDNNNLRSAVISDAPLLPPSSSIGVGVSSGGGYPPEAVLRTPYGNVRALPGPAQPPPLPQSPFQQTQQYGGFGSGYGGNNYGLGGYGGFNSGAFGYGGLGGFGSGLGSGFGSGYGYGGGYGGGYGGGFGGGYNRFGAMGENDAEQRFIYMAESSSRPAFQSIESLVSAIGNIASMLDSTFFALTSSFRAILGVATNFVRLRSVFAQFWTTFAIFRGLNWMYRKILYWLRLSNLDPSSAAFKKAFAEALNENNGQARGAPNVPRKGNSPWPVLAFISFIFTAPYLIMKLLGTVTNTAQEEARNPAKWTAPIQTQAVYEFVARSPSELSLRAGQMLHVAPRDIQQTLNLLNTGWALATTNGQTSGIIPISYVKSPQQMRQEMQDQTKPAQPQPELMNLSAGAFASPPLEQQMNYDFNLAAQQQAPLGPPSTTSAVLGEGFA
InterPro domains: - IPR035463: Peroxin 13 (family) [52-310]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [311-395]
- IPR001452: SH3 domain (domain) [308-376]
- IPR007223: Peroxin 13, N-terminal (domain) [148-290]
Interaction partners: - Peroxin-19
- Peroxisomal membrane protein PEX14
- Peroxisomal targeting signal 1 receptor
- Peroxisome assembly protein 12
- RING-type E3 ubiquitin transferase
- Peroxin-7
- Peroxin 11
- Peroxisomal biogenesis factor 3
- Peroxisomal membrane protein PEX16
- Peroxisome biogenesis factor 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding), GO:0043495 (protein-membrane adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: Keratin-associated protein 25-1 (Q3LHN0)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Sequence: MHNRSQGFFFSSCHPQNHVSYGCQSPSFIFCRCQSLNFVSRTCYPLSYFSYGNQTIGSISNSFRSLNYVSHSFQPISFMHSSFQPACSDFVGWQSPFLRRTC
InterPro domains: - IPR007659: Keratin, high-sulphur matrix protein (family) [3-88]
- IPR007951: Keratin-associated protein, PMG type (family) [7-87]
Interaction partners: - Keratin-associated protein 27-1
- Keratin-associated protein 24-1
- Keratin-associated protein 26-1
- Small cysteine and glycine repeat-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0016043 (cellular component organization), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007283 (spermatogenesis), GO:0048515 (spermatid differentiation), GO:0043933 (protein-containing complex organization), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007010 (cytoskeleton organization), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Trafficking protein particle complex subunit 2-like protein (Q9UL33)
Organism: Homo sapiens (Human)
Function: Plays a role in vesicular transport from endoplasmic reticulum to Golgi.
Subcellular location: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19416478}. Endoplasmic reticulum {ECO:0000269|PubMed:19416478}. Golgi apparatus {ECO:0000269|PubMed:19416478}.
Sequence: MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSSRAFDNMVTSMMIQVC
InterPro domains: - IPR006722: Trafficking protein particle complex subunit 2 (family) [1-136]
- IPR011012: Longin-like domain superfamily (homologous_superfamily) [3-132]
- IPR044760: Trafficking protein particle complex subunit 2-like (family) [3-136]
Interaction partners: - Trafficking protein particle complex subunit 10
- Trafficking protein particle complex subunit 3
- Trafficking protein particle complex subunit 6B
- Trafficking protein particle complex subunit 9
- Trafficking protein particle complex subunit 1
- Trafficking protein particle complex subunit 2
- Trafficking protein particle complex subunit 4
- Trafficking protein particle complex subunit 5
- Trafficking protein particle complex subunit 11
- Trafficking protein particle complex subunit 12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)