wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Anthocyanidin 3-O-galactosyltransferase 3GT6 (P0DO59)
Organism: Rhododendron delavayi (Rhododendron) (Rhododendron arboreum subsp
Function: Flavonoid 3-O-glycosyltransferase involved in the biosynthesis of anthocyanins conferring flower red/pink colors, mainly anthocyanidin 3-O-glycosides. Catalyzes the addition of UDP-sugar to the 3-OH of anthocyanidin, with a preference for UDP- galactose (UDP-Gal) as sugar donor and cyanidin as substrate; able to use delphinidin, pelargonidin, peonidin and petunidin as substrates in the presence of UDP-Gal, but barely active on malvidin. Can also use UDP-glucose (UDP-Glu) as sugar donor with cyanidin, delphinidin, pelargonidin, peonidin and petunidin as substrates, but not active on malvidin
Sequence: MTNSSKGRHVAVLPFPFSTHAAPILSIIRRLASAAPDVTFSFFSTPQSIQTLFPSENPENNIRPHAISDGVPEGFVFSGKHHEDINLFLAAGKESFEAGMKAAEAETGRRIDCVVSDAFMWFSCELAEEMGVPWVTLWVSGACSLAAHCYTDLIRETVGMHDTAGREDEIVKFVPGFSEVRLGDLPSGVVYGNLESPFSMMLYKMGQVLHKAAAVAINSFDELEPEPVKVLASKLKLLTCGPFNPISPPPSSNLDEYGCIPWLDRRKAASVAYIGFGTVATPPPVELAALAEALEASSTPFLWSLRDNPKQHLPEGFLKRTSELQKIVPWAPQAQVLAHRSVGVFINHCGWNSVVESVEAGVPIIGRPFFGDHQVDAWMVENVWKIGVRVEGAVFTKGITMSALELVLSHDQKQKELREQVGKYKEFALKAFGPKQRSTCNLSTLLEIVAGYNL
InterPro domains: - IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [9-415]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042440 (pigment metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0046283 (anthocyanin-containing compound metabolic process), GO:0009812 (flavonoid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046148 (pigment biosynthetic process), GO:0009718 (anthocyanin-containing compound biosynthetic process), GO:0009813 (flavonoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein FAM50A (Q568K9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Probably involved in the regulation of pre-mRNA splicing
Subcellular location: Nucleus
Sequence: MAQYKGAASEAGRAMQLMKKREREREQLEQLKQKIAEDNMVKSNIDKKFSAHYDAVEQELKSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQLKLEKQKEKKRKEEQKRKIASLSFNPDEGEDEEEEEEEEEEEEEDEIEEEICLPVKKKKLGKNPDVDTSFLPDRDREEEENRLREELRQEWERKQEKIKSEEIEITFSYWDGSGHRKTVKMKKGNTIQQFLQRALEVLRKDFSELRSAGVEHLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDIRLVNDATVEKDESHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR
InterPro domains: - IPR048337: FAM50A/XAP5, C-terminal domain (domain) [199-339]
- IPR007005: XAP5 protein (family) [1-341]
Interaction partners: - FLJ22626-like
- Zgc:103692
- Regulator of nonsense transcripts 3B
- Pre-mRNA-splicing factor SLU7
- Pre-mRNA-splicing factor syf2
- Splicing regulator SDE2
- PRKR-interacting protein 1 homolog
- Protein FAM32A-like
- Pre-mRNA-splicing factor CWC22 homolog
- Peptidyl-prolyl cis-trans isomerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0010941 (regulation of cell death), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0043067 (regulation of programmed cell death), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cytosine deaminase (P78594)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis
Subcellular location: Cytoplasm. Nucleus
Sequence: MTFDDKKGLQVALDQAKKSYSEGGIPIGSCIISSDDTVLGQGHNERIQKHSAILHGEMSALENAGRLPGKTYKDCTIYTTLSPCSMCTGAILLYGFKRVVMGENVNFLGNEKLLIENGVEVVNLNDQECIDLMAKFIKEKPQDWNEDIGE
InterPro domains: - IPR002125: Cytidine and deoxycytidylate deaminase domain (domain) [3-121]
- IPR016193: Cytidine deaminase-like (homologous_superfamily) [5-148]
- IPR016192: APOBEC/CMP deaminase, zinc-binding (binding_site) [55-91]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0019239 (deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0009112 (nucleobase metabolic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0006206 (pyrimidine nucleobase metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: High affinity immunoglobulin epsilon receptor subunit alpha (P12319)
Organism: Homo sapiens (Human)
Function: High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence: MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [26-198]
- IPR050488: Immunoglobulin Fc region receptor (family) [27-199]
- IPR007110: Immunoglobulin-like domain (domain) [30-193]
- IPR003598: Immunoglobulin subtype 2 (domain) [42-183]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [26-201]
- IPR003599: Immunoglobulin domain subtype (domain) [36-195]
Interaction partners: - High affinity immunoglobulin epsilon receptor subunit gamma
- High affinity immunoglobulin epsilon receptor subunit beta
- Tyrosine-protein kinase SYK
- Tyrosine-protein kinase Fyn
- Mast cell carboxypeptidase A
- Immunoglobulin heavy variable 4-38-2
- Tyrosine-protein kinase Lyn
- B-lymphocyte antigen CD20
- Immunoglobulin alpha Fc receptor
- Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0140352 (export from cell), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0035592 (establishment of protein localization to extracellular region), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0015031 (protein transport), GO:0071692 (protein localization to extracellular region)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0005886 (plasma membrane)
Protein: Filamentous growth regulator 23 (Q5AJV5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth
Subcellular location: Cell membrane; Lipid-anchor, GPI- anchor
Sequence: MFASYLLLVLWIIRLVPTTHAHTGNDAEYLLNTVLKRDATSLSRNAYLDSEATSGATNYCSDCDNDEVIVTVDGTSTIWTILLDSTISTLVTTTSTEKTTLTSCGQSCTKSKDASSVSSSSASSSTSRSLIFRTSTKTVTDTTTLPTVTEINTFTTTDSHIVLVYTDINSESTITGDYTFIKNKNTRTVIITDYVTSTVGGETQIVTQTTTSVVYELVVTCPDHDFATTLTGSETFVPPTTAPKPVETPSPEPSTTILSIKSESSVPSATTSVLDTSITLETSSSSIEFSTSTQESSSIGPSSSSSIGSCTSSSISTEESLSTTKLSSSFTSISSWEELSSSFTQSTTSSNAEPSSSFAESFTTESLSSTIEATSSMEDISNNSVLTSSIFSETTTNESSSYTDEPSSSEEITNTYEPSSSTESSTTDQFSSLLSSSLPVTSTSSTTISSATPITTVLSTSITSQDTNCEATITNISTNTLIETITVNGNTTIYTETQLSTYLTSNTSINCPNTNSATTTTTQVIPTATTEQIHTTTLNGSIIVSTETATLKTTVIITHCPECTNESSTSEYSSSLKAESSQQSIPTIESNLSELSVSSTLSLVESTASGKCSGLTTTTFTSIVSTTTESIYTITSNESTFEMTTTVTNIGTIVITTCPTITPVSSSYSSSESLSSSVSTSLLTESNSTISQSTVSTDKSSLTNDNQISTVSTETPLTSITIIETTSKTTESLYTTTSNDSTHIFTTTIIDVQTNTIVTCPTTTSTLTSSHTSDNEKPASLSSSSLIESDHIADGTTTSTTFQSTSTTTVDHHCSSCSEILLSTSSSIIGNKSTSTSISSIETSASSSYHSSEPEVMSSSSSTSIKQSSDSIPSTSQTHVSTTSSSVSSLETTTTTTENSPTSNGFSSSSIVTSVNVPDYVSSSVSSTSSTTSSPSTESSSNGLVSTVTESSTANENTSEITTIDNTSITSEKVTGTNSNPKTSEIIKDATITTSGNVESLHSTTPISSTSIISTNAISSSDTTTLTITNTLTYSIDSITTMKTSSITTAPPPPQQKESSSVLSSSLIINSSTPTIIPTINIPITFEGNANSLGLKNGDNSWIIGIMMIGLLMI
Interaction partners: - DNA repair protein RAD51 homolog
- E3 ubiquitin ligase complex SCF subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0030447 (filamentous growth), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0016043 (cellular component organization), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Transcriptional regulator of filamentous growth FLO8 (Q59QW5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections
Subcellular location: Nucleus
Sequence: MVPNTTKQVLNSLILDFLVKHQFQDTAKAFSKESPNLPSIPPLMDCSQGFLLEWWQVFFDLFQVRYGDGNSNNNPNNKLYHDYLRVQETQKHLFSQLPLIQQQQQQQHHFQQQQQQQGQQGQPFSQQQQRGIGVASGMQNQQHQFAPQHQGQPQGPGQTPQPPGSATNANFPINMPPNSNPQQQMFPINQQFAQMPNGQNQPSMEQQQRMAMMMKQQAMAAQRQQIPMNGLDPQQQQQMMNAVGGGPGNLNLQQQLFLQQQQQQQQQPKTTFQQQAQNQMNNLRQQAAMVAQQQQQQQQQQQQQGQLQGNLASAMGDSSSKNNSPVGARSNQQSTPQQNAAPAPSPHPSQQGQAQAQHNFQSQQQQQQQQMTKMAGSQGMKKNGQMSNGTSNNSSGRNNNALRDYQNQLMLLERQNKERLEFARNTGNSDSNPLSNGMMFAGQNQYSNSNQNQNQLPPNQQQPTPATFHPPPPPTTANGPQGQFNQKPSPATSNNSPALGNKSSPAMGNKKSKKESNSKKGKKANSNASTTANNKTSGQTTPNMSQPPSAGTEPKQPQPTEQMRQLQDKQQRPGSNTPSMGKKDFQPLTPRSEPISGETTKKKRKSGKLNDNNENSNGNSPKKQAKTNANSKNLDPIIKEEENGVLSLKKESSTSLQDQDLDLNPPLAPTQATAMSNTFNDDPFDVHLLDTQHHHQQNSNNSNHNRGQNLSNGSNNLSVSGPGMGMNNSVFGDSTHAFDINFNIDSLDDIWTTTGPGGDITGTGSGSGGAGGTDDDNFMGMNWAADPIENGD
InterPro domains: - IPR006594: LIS1 homology motif (conserved_site) [6-38]
Interaction partners: - Enhanced filamentous growth protein 1
- RFX-like DNA-binding protein RFX2
- Transcription activator TEC1
- Transcription activator MSS11
- Morphogenetic regulator of filamentous growth protein 1
- Transcription factor NDT80
- Biofilm and cell wall regulator 1
- Biofilm regulator 1
- Zinc cluster transcription factor CZF1
- Transcription factor ROB1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization), GO:0000002 (mitochondrial genome maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Thiol-specific monooxygenase (Q9HFE4)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Flavin-dependent oxidation of thiol-containing compounds. Probably required for the correct folding of disulfide-bonded proteins (By similarity)
Sequence: MCLPTIRKIAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGGVWNYTSTLSNKLPVPSTNPILTTEPIVGPAALPVYPSPLYRDLQTNTPIELMGYCDQSFKPQTLQFPHRHTIQEYQRIYAQPLLPFIKLATDVLDIEKKDGSWVVTYKGTKAGSPISKDIFDAVSICNGHYEVPYIPNIKGLDEYAKAVPGSVLHSSLFREPELFVGESVLVVGGASSANDLVRHLTPVAKHPIYQSLLGGGDIQNESLQQVPEITKFDPTTREIYLKGGKVLSNIDRVIYCTGYLYSVPFPSLAKLKSPETKLIDDGSHVHNVYQHIFYIPDPTLAFVGLALHVVPFPTSQAQAAFLARVWSGRLKLPSKEEQLKWQDELMFSLSGANNMYHSLDYPKDATYINKLHDWCKQATPVLEEEFPSPYWGEKERSIRENMWSIRAKFFGIEPPK
InterPro domains: - IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [4-433]
- IPR050346: Flavin-containing monooxygenases-like (family) [7-238]
- IPR000960: Flavin monooxygenase FMO (family) [7-369]
- IPR020946: Flavin monooxygenase-like (family) [84-371]
Interaction partners: - Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Ubiquinone biosynthesis protein coq9, mitochondrial
- 5-demethoxyubiquinone hydroxylase, mitochondrial
- Probable serine hydroxymethyltransferase, cytosolic
- 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Atypical kinase COQ8, mitochondrial
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0034975 (protein folding in endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ferritin heavy chain (P41822)
Organism: Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Subcellular location: Secreted. Cytoplasm
Sequence: MMKSVFFGVVAITVAILSIYQETAQAQEQTVGATDNYQWDSVDDQCLAALHRQINKEFDASIIYLKYAAYFAQEKINLPGFEKFFFHSAAEEREHGIKLIEYALMRGKAPVDKHFKLNYDHEVPTVTTGESALETALQKEVEVTKSIRGVIKACEDGSNDFHLADYLTGEYLDEQHKGQRELAEKIATLKKMKKSAPKLGEFLFDKNHM
InterPro domains: - IPR009078: Ferritin-like superfamily (homologous_superfamily) [36-207]
- IPR008331: Ferritin/DPS domain (domain) [48-192]
- IPR009040: Ferritin-like diiron domain (domain) [40-193]
- IPR001519: Ferritin (family) [41-207]
- IPR012347: Ferritin-like (homologous_superfamily) [16-208]
Interaction partners: - Ferritin
- Ferritin
- Ferritin
- Ferritin
- AAEL000588-PA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Ferritin heavy chain (I4DJ24)
Organism: Papilio xuthus (Asian swallowtail butterfly)
Function: Stores iron in a soluble, non-toxic, readily available form (By similarity). Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity). Ferritin is composed of a heavy (H) chain which is responsible for the oxidation and uptake of ferrous iron, and a light (L) chain which facilitates the nucleation of the ferrihydrite iron core (By similarity)
Subcellular location: Golgi apparatus. Secreted
Sequence: MKAVLFAVAALLAVCIPISAKQCNVNPVNIPKGWITMQQSCRGSMRRQIQTEVGASLQYLAMGAHFSRDGINRPGFAKLFFDAASEEREHAMKLIDYLLMRGELETDVTSLIQIRAPERKSWESGVDALEHALKMETEVTKSIRSVIIACESDPKFNDYHLVDYLTGEFLEEQYKGQRDLAGKASTLKKMLDRHSSLGEFLFDKKLLGMDI
InterPro domains: - IPR009078: Ferritin-like superfamily (homologous_superfamily) [22-209]
- IPR008331: Ferritin/DPS domain (domain) [46-189]
- IPR009040: Ferritin-like diiron domain (domain) [35-191]
- IPR001519: Ferritin (family) [37-208]
- IPR012347: Ferritin-like (homologous_superfamily) [21-211]
Interaction partners: - Ferritin
- Serine protease snake
- Heme oxygenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0052553 (modulation by symbiont of host immune response), GO:0052559 (induction by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0140535 (intracellular protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005770 (late endosome), GO:0031904 (endosome lumen), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0043202 (lysosomal lumen)