Protein: Probable delta-1-pyrroline-5-carboxylate synthase (P5CS) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Aldehyde dehydrogenase family 13) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)] (P54889)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MFRATRCLRLPLRNSHINILRPTQTELIKTRSSALAPYEKVSPITAVGATPVGVGNGNYCYSTKTRQKHPLINTRNDLKKAQRVVVKLGSAVITREDECGLALGRLASIVEQVSELQQSGRQMLIVSSGAVAFGRQKLRQELVMSMSMRQTLRGPSGMTADKRACAASGMPGLMSLYEQLFQQYGITVAQVLLTKPDIDDDQRRKNLQATIESLLSLNIIPIVNANDAVAPDPKLNMHISDNDSLAARLSAEIEAELLIILSNVNGVYTGPPDLEGSRLLYTYVPSENSGVTFGANSKFGTGGMESKVTACVNALNNGVTTVITNGLAQDAITDAVAGKKIGTMFCNTKGYEGPPIEEVAEKCRDAGRQLAALSNKERGAMVRHLAALLVDKEKYIIEANQTDLANAKSAGLDPQLLNRLKMTPEKIQDLHAGLNTIADSAETLVGRVLKKVKISEGLFLEQVTVPIGSLMVIFESRPDCLPQVASLAMASGNALLLKGGKEAEESNKALHALVQEALGTHGFEMRDAVTLVRSREDVADLLQLKDLIDLIIPRGSSDLVRSMQEKSKGIPVLGHAEGVCHVYIDKDCDEQKAIQIVRDSKCDYPSACNAAETILIHKDLATAPFFDSLCSMFKAEGVKLHAGPKLAALLKFAPPPAESMSFEYGSLECTLEVVDNVEEAVAHIIRYGSGHTESIITENTNTAEHFLKHVDSACAFHNASTRFADGYRFGLGAEVGISTGRIHARGPVGVEGLLTTKWLLRGEGHLVEDFKNGKYSYLHENLNPSEVYRALDAAGELKKATA
InterPro domains: - IPR001048: Aspartate/glutamate/uridylate kinase (domain) [83-325]
- IPR015590: Aldehyde dehydrogenase domain (domain) [354-629]
- IPR000965: GPR domain (domain) [355-767]
- IPR036393: Acetylglutamate kinase-like superfamily (homologous_superfamily) [71-350]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [356-766]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [364-765]
- IPR005715: Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase (family) [82-350]
- IPR041744: Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain (domain) [74-346]
- IPR020593: Gamma-glutamyl phosphate reductase GPR, conserved site (conserved_site) [674-696]
- IPR005766: Delta l-pyrroline-5-carboxylate synthetase (family) [18-792]
- IPR001057: Glutamate/acetylglutamate kinase (family) [120-319]
- IPR019797: Glutamate 5-kinase, conserved site (conserved_site) [297-314]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [577-725]
Interaction partners: - Probable ornithine aminotransferase, mitochondrial
- Multifunctional fusion protein
- Putative pyrroline-5-carboxylate reductase 4
- glutamate synthase
- Glutamate dehydrogenase
- Pyrroline-5-carboxylate reductase
- Putative glutaminase 3
- Putative glutaminase 2
- glutaminase
- NADPH:adrenodoxin oxidoreductase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016491 (oxidoreductase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016301 (kinase activity), GO:0016774 (phosphotransferase activity, carboxyl group as acceptor), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0019202 (amino acid kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0006560 (proline metabolic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0006561 (proline biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)