Protein: Nucleolar complex-associated protein 3 (O94288)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:10759889}.
Sequence: MAARKNQKSPKPKVASSKLKNIKKSSKRNNSQSSTEPRKNATSLDSKKTTKKGVALPEIAERELTQEDIEFFNENPSSLKYLSSINPEDLGKKVEKGPRPDIYDLKKSQQFELDTSRLSSDEESVLDYSKDSEDEQDYELRPRVSSSWNNESYNRLPIKTKDGLLQNVVADVNNGEEFLSESESEASLEIDSDIKDEKQKSLEEQKIAPEIPVKQQIKNDKEALGIQAQQLLEEPVENLHLIRNIFEKFDSPYITIKKLSLLTLLAVFRDIIPGYKIRPLSEEEQGTKLSKEVAQRWEYEQTLLKHYAKFLQTLETILKSFSSTLDETQLSLYQVAVRCCTKLIEQASHFNLSEKLFALAVRQISHKTKRPGFDGIINSLKNIFEEDNLGKTSLKCVTILSRMFKQRNYDVLPDVYDLFLSVNILNDMKIKDEAWQDDTTNFKKRKKDLPYLTKKARKNYKETKKITQEMKEADAVITAQDKEKYQSEILKIIFITYFKTLQLKGKLIGNALEGVARLSHLLNIEFLGDLLQVLRELVMDDTVFLPKDKSGVQATREALLTVSTAFEIASAQGVGKLNLDLDLGLFVQRLYKIIFPFSLNPDADLNLKIKRLKDPDAPSKPFVVNATTEMEMLLKCFQVFFFKSKNISSSRLSSFSKRLAIASMQLPEHSASADLALLKKLLSRYSKLSRLLTSEEQIGDGIYNPFIEDPDLSNSSTAVLYEPFLLKNHYSPAVSQSAKELLKSTSL
InterPro domains: - IPR011501: Nucleolar complex-associated protein 3, N-terminal (domain) [220-310]
- IPR016903: Nucleolar complex-associated protein 3 (family) [1-747]
- IPR005612: CCAAT-binding factor (domain) [559-738]
Interaction partners: - Ribosome biogenesis protein erb1
- Uncharacterized NOC2 family protein C1142.04
- Probable nucleolar GTP-binding protein 1
- Protein mak16
- Pescadillo homolog
- Ribosome biogenesis protein ytm1
- Ribosome biogenesis protein brx1
- AdoMet-dependent rRNA methyltransferase spb1
- Uncharacterized RNA-binding protein C1827.05c
- GTPase grn1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044786 (cell cycle DNA replication), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0033260 (nuclear DNA replication), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0006259 (DNA metabolic process), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0042254 (ribosome biogenesis), GO:0006260 (DNA replication), GO:0016070 (RNA metabolic process), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0006270 (DNA replication initiation), GO:0006396 (RNA processing), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0006261 (DNA-templated DNA replication), GO:0042255 (ribosome assembly), GO:0034470 (ncRNA processing), GO:0140694 (non-membrane-bounded organelle assembly), GO:0065004 (protein-DNA complex assembly), GO:0000027 (ribosomal large subunit assembly), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)