Protein: Sorting nexin-7 (Q9CY18)
Organism: Mus musculus (Mouse)
Function: Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Together with SNX4, involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A.
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q9UNH6}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95219}; Cytoplasmic side {ECO:0000250|UniProtKB:O95219}.
Sequence: MDMNSFSPMMPTSPLSMINQIKFEDGPDLKDLFITVDAPESHVTTIETFITYRIVTKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKVFLTAQAEELSSYKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIETFSQKINLIDKISQRIYKEERDYFDEMKEYGPIHILWSASEEELVDTLKGMAGCIEQCCKATEKRMAGLSEALLPVVHEYVLYSEMLVGVMKRRDQIQTELDSKVEALTYKKADIDLLTEEIGKLEDKVECANNALKADWERWKQNMKNDLRSAFTDTAEQNIRYYEQCLATWESFLTSQTDLPSEEDSEEKL
InterPro domains: - IPR027267: AH/BAR domain superfamily (homologous_superfamily) [179-376]
- IPR042131: SNX7, BAR domain (domain) [131-373]
- IPR042130: SNX7, PX domain (domain) [32-147]
- IPR001683: Phox homology (domain) [27-151]
- IPR036871: PX domain superfamily (homologous_superfamily) [25-157]
Interaction partners: - Sorting nexin-4
- Vacuolar protein sorting-associated protein 35
- Vacuolar protein sorting-associated protein 29
- Sorting nexin-6
- Sorting nexin-32
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0045184 (establishment of protein localization), GO:0009896 (positive regulation of catabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0071705 (nitrogen compound transport), GO:0010508 (positive regulation of autophagy), GO:0015031 (protein transport), GO:1902117 (positive regulation of organelle assembly), GO:0010506 (regulation of autophagy), GO:0033043 (regulation of organelle organization), GO:0071702 (organic substance transport), GO:0031331 (positive regulation of cellular catabolic process), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0010638 (positive regulation of organelle organization), GO:1902115 (regulation of organelle assembly), GO:2000786 (positive regulation of autophagosome assembly), GO:0016241 (regulation of macroautophagy), GO:0044090 (positive regulation of vacuole organization), GO:0044088 (regulation of vacuole organization), GO:2000785 (regulation of autophagosome assembly), GO:0016239 (positive regulation of macroautophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane)