Protein: Proteinaceous RNase P 3 (EC 3.1.26.5) (F4JKB6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Endonuclease RNase P responsible for the 5' maturation of tRNA precursors. Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA).
Subcellular location: Nucleus {ECO:0000269|PubMed:20473316}.
Sequence: MKLKKPSLPSSLLCAVPPCLSQIRLLIPRRVRVSSSTFANAKLVTLRNHTVNLHIYYCSMAGTDNRRSRHDDESPKNPNKKKKGNRNPEKSLLINLHSCSKRKDLSAALALYDAAITSSDIRLNQQHFQSLLYLCSAFISDPSLQTVAIDRGFQIFDRMVSSGISPNESSVTAVARLAAAKGDGDYAFKLVKDLVAVGGVSVPRLRTYAPALLCFCDTLEAEKGYEVEDHMDASGIVLEEAEISALLKVSAATGRENKVYRYLQKLRECVGCVSEETSKAIEEWFYGVKASEVSDNGIGSDIELLRAAVLKNGGGWHGLGWVGEGKWIVKKGNVSSAGKCLSCDEHLACVDTNEVETEDFVNSLVTLAMERKAKMNSCEPMADFSEFQEWLEKHGDYEAILDGANIGLYQQNFADGGFSLPQLEAVVKELYNKSGSKKQPLILLHKKRVNALLENPNHRNLVEEWINNNVLYATPPGSNDDWYWLYAAAKLKCLLVTNDEMRDHIFELLSNSFFQKWKERHQVRFTFVKGCLKLEMPPPFSVVIQESEKGSWHVPITSQDKEESLRSWMCITRQSS
InterPro domains: - IPR031595: Protein-only RNase P, C-terminal (domain) [335-570]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [88-571]
- IPR033443: PROP1-like, PPR domain (domain) [79-292]
Interaction partners: - Protein GAMETOPHYTE DEFECTIVE 1
- Proteinaceous RNase P 1, chloroplastic/mitochondrial
- Ribonucleases P/MRP protein subunit POP1
- Proteinaceous RNase P 2
- Probable ribonuclease P/MRP protein subunit POP5
- Uncharacterized mitochondrial protein AtMg01280
- Pentatricopeptide repeat-containing protein At3g06430, chloroplastic
- Pentatricopeptide repeat-containing protein At5g04810, chloroplastic
- Pentatricopeptide repeat-containing protein At1g10270
- Small ribosomal subunit protein mL104
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0140101 (catalytic activity, acting on a tRNA), GO:0004540 (ribonuclease activity), GO:0004549 (tRNA-specific ribonuclease activity), GO:0004519 (endonuclease activity), GO:0004521 (RNA endonuclease activity), GO:0004526 (ribonuclease P activity), GO:0016891 (RNA endonuclease activity, producing 5'-phosphomonoesters), GO:0016893 (endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0034470 (ncRNA processing), GO:0000966 (RNA 5'-end processing), GO:0034660 (ncRNA metabolic process), GO:0016074 (sno(s)RNA metabolic process), GO:0043144 (sno(s)RNA processing), GO:0099116 (tRNA 5'-end processing), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing), GO:0001682 (tRNA 5'-leader removal)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)