Protein: Small ribosomal subunit protein uS15 (P62301)
Organism: Mus musculus (Mouse)
Function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)
Subcellular location: Cytoplasm. Nucleus, nucleolus
Sequence: MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKGLTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHLERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA
InterPro domains: - IPR012606: Small ribosomal subunit protein uS15, N-terminal (domain) [1-60]
- IPR009068: uS15/NS1, RNA-binding domain superfamily (homologous_superfamily) [66-142]
- IPR023029: Small ribosomal subunit protein uS15, archaea/eukaryota (family) [1-151]
- IPR000589: Small ribosomal subunit protein uS15 (family) [70-149]
Interaction partners: - Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Polyubiquitin-C
- Small ribosomal subunit protein eS21
- Large ribosomal subunit protein uL13
- Large ribosomal subunit protein uL4
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein eS1
- Large ribosomal subunit protein uL11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0000902 (cell morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0043603 (amide metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0006935 (chemotaxis), GO:0044260 (cellular macromolecule metabolic process), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0043604 (amide biosynthetic process), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0034248 (regulation of amide metabolic process), GO:0007399 (nervous system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:0070925 (organelle assembly), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0017148 (negative regulation of translation), GO:0043043 (peptide biosynthetic process), GO:0065003 (protein-containing complex assembly), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007411 (axon guidance), GO:0022618 (ribonucleoprotein complex assembly), GO:0031175 (neuron projection development), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0048699 (generation of neurons), GO:0006417 (regulation of translation), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0010608 (post-transcriptional regulation of gene expression), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)