wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Protein RER1 (Q6PE45)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MPEGDSAGESIHGKPSAIGNFFKRLGQIYQSWLDKSTPFSAVRWASTLILTAIYMIRVYILQGWYIVTYALGIYHLNLFIAFLSPKVDPSLLDDPDEGPALPTKQNEEFRPFIRRLPEFKFWHSATKGIVIAMICTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYLPFTHGKRTYRGKDDTGKTFAS
InterPro domains: - IPR004932: Retrieval of early ER protein Rer1 (family) [3-194]
Interaction partners: - Si:ch211-255f4.7.
- Family with sequence similarity 113
- ATP-dependent RNA helicase DDX51
- Tumor protein p63-regulated 1-like
- AP2-associated kinase 1a.
- HEPACAM family member 2
- peptidylprolyl isomerase
- Exonuclease 3'-5' domain-containing 3.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, chloroplastic (MECDP-synthase) (MECPS) (MECS) (EC 4.6.1.12) (Q9CAK8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP. Is essential for chloroplast development.
Subcellular location: Plastid, chloroplast stroma {ECO:0000305|PubMed:18236010}.
Sequence: MATSSTQLLLSSSSLFHSQITKKPFLLPATKIGVWRPKKSLSLSCRPSASVSAASSAVDVNESVTSEKPTKTLPFRIGHGFDLHRLEPGYPLIIGGIVIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDIGQIFPDSDPKWKGAASSVFIKEAVRLMDEAGYEIGNLDATLILQRPKISPHKETIRSNLSKLLGADPSVVNLKAKTHEKVDSLGENRSIAAHTVILLMKK
InterPro domains: - IPR003526: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (domain) [34-231]
- IPR020555: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site (conserved_site) [109-124]
- IPR036571: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase superfamily (homologous_superfamily) [72-231]
Interaction partners: - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
- 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase, chloroplastic
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic
- 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic
- 1-deoxy-D-xylulose-5-phosphate synthase
- Hydroxymethylglutaryl-CoA synthase
- 1-deoxy-D-xylulose-5-phosphate synthase
- Phosphomevalonate kinase, peroxisomal
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:1901661 (quinone metabolic process), GO:0042181 (ketone biosynthetic process), GO:0006743 (ubiquinone metabolic process), GO:1901663 (quinone biosynthetic process), GO:0006744 (ubiquinone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ATPase, F0/V0 complex, subunit C protein (B3H4N3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MSGVVALGHASSWGAALVRISPYTFSAIGIAISIGVSVLGAAWGIYITGSSLIGAAIEAPRITSKNLISVIFCEAVAIYGVIVAIILQTKLESVPSSKMYDAESLRAGYAIFASGIIVGFANLVCGSVSTLFSFLTVLVFGFHCQICNRGPHFSCRLCVGIIGSSCALSDAQNSTLFVKILVIEIFGSALGLFGVIVGIIMSAQATWPTK
InterPro domains: - IPR002379: V-ATPase proteolipid subunit C-like domain (domain) [28-201]
- IPR035921: F/V-ATP synthase subunit C superfamily (homologous_superfamily) [21-207]
- IPR000245: V-ATPase proteolipid subunit (family) [39-89]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0019725 (cellular homeostasis), GO:0006885 (regulation of pH), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0030641 (regulation of cellular pH), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0051453 (regulation of intracellular pH), GO:0006811 (monoatomic ion transport), GO:0051452 (intracellular pH reduction), GO:0006812 (monoatomic cation transport), GO:1902600 (proton transmembrane transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0007035 (vacuolar acidification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ankyrin repeat-containing protein 2 (F4JN13)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MASNSEKNPLLSDEKPKSTEENKSSKPESASGSSTSSAMPGLNFNAFDFSNMASILNDPSIREMAEQIAKDPAFNQLAEQLQRSIPNAGQEGGFPNFDPQQYVNTMQQVMHNPEFKTMAEKLGTALVQDPQMSPFLDAFSNPETAEHFTERMARMKEDPELKPILDEIDAGGPSAMMKKNYLFCFRYWNDPEVLKKLGEAMGMPVAGLPDQTVSAEPEVAEEGEEEESIVHQTASLGDVEGLKAALASGGNKDEEDSEGRTALHFACGYGELKCAQVLIDAGASVNAVDKNKNTPLHYAAGYGRKECVSLLLENGAAVTLQNLDEKTPIDVAKLNSQLEVVKLLEKDAFL
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [224-350]
- IPR002110: Ankyrin repeat (repeat) [225-323]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Potassium channel toxin alpha-KTx 8.8 (OSK3) (A0A1L2FZD4)
Organism: Orthochirus scrobiculosus (Central Asian scorpion)
Function: Selectively inhibits voltage-gated potassium channels rKv1.2/KCNA2 (IC(50)=331 nM) and hKv1.3/KCNA3 (IC(50)=503 nM). Partially inihibts rKv1.6/KCNA6 (IC(50)=9983 nM).
Subcellular location: Secreted {ECO:0000269|PubMed:28179135}.
Sequence: MCRLYAIILIVLVMNVIMTIIPDSKVEVVSCEDCPEHCSTQKARAKCDNDKCVCEPI
InterPro domains: - IPR036574: Knottin, scorpion toxin-like superfamily (homologous_superfamily) [29-57]
- IPR008911: Short scorpion toxin, potassium channel inhibitor alpha-KTx 8/9 (family) [29-56]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0016247 (channel regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0016248 (channel inhibitor activity), GO:0099106 (ion channel regulator activity), GO:0008200 (ion channel inhibitor activity), GO:0015459 (potassium channel regulator activity), GO:0019870 (potassium channel inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044359 (modulation of molecular function in another organism)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Fasciclin-like arabinogalactan protein 18 (Q93W32)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be a cell surface adhesion protein.
Subcellular location: Secreted {ECO:0000305}.
Sequence: MDRCIYGCSVITIFFSFFFLLNASALESGHHNITGSGQINSNSVLVALLDSRYTELAELVEKALLLQTLEDAVGRHNITIFAPRNEALERDLDPDFKRFLLQPGNLKSLQTLLLSHIIPKRVGSNQWPEENSGRVKHVTLGHDQVLHLSKLKGTNGKRLVNSAVITRPDDLTRPDGLIHGIERLLIPRSVQEDFNRRRNLRSISAVLPEGAPEIDPRTNRLKKSATAVSVPAGSPPVLPIESAMAPGPSLAPAPAPGPGGAHKHFNGDAQVKDFIHTLLHYGGYNEMADILVNLTSLATEMGRLVSEGYVLTVLAPNDEAMGKLTTDQLSEPGAPEQIMYYHIIPEYQTEESMYNSVRRFGKVKYETLRFPHKVGAKEADGSVKFGSGDRSAYLFDPDIYTDGRISVQGIDGVLFPEEKEEETVKKPTGPVKKVVQPRRGKLLEVACSMLGAIGKDSYLSRC
InterPro domains: - IPR044654: Fasciclin-like arabinogalactan protein 15/16/17/18 (family) [11-454]
- IPR000782: FAS1 domain (domain) [40-417]
- IPR036378: FAS1 domain superfamily (homologous_superfamily) [31-417]
Interaction partners: - Putative defensin-like protein 263
- Fasciclin-like arabinogalactan protein 9
- Fasciclin-like arabinogalactan protein 13
- Fasciclin-like arabinogalactan protein 21
- Fasciclin-like arabinogalactan protein 4
- Fasciclin-like arabinogalactan protein 1
- Fasciclin-like arabinogalactan protein 2
- Putative fasciclin-like arabinogalactan protein 20
- Fasciclin-like arabinogalactan protein 19
- Fasciclin-like arabinogalactan protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030246 (carbohydrate binding), GO:0030247 (polysaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901700 (response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0097305 (response to alcohol), GO:0009737 (response to abscisic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009505 (plant-type cell wall)
Protein: FI18835p1 (Uncharacterized protein, isoform A) (Q9VCV9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSEPAAQQQQSQNGKERSKSTEEKEVPREPALVLKDIDIKTELESLVKLLDGKIYKEEEVAMEELHQYLIEDDGSWALGDNFLIFVQRVLRDNQAFSPDTRIHLIRTLAYAALKDDVIIILHQDRRDHTLMNYAQDIDKQTPEEQQAWAMFMCNLFENLGPSEWLLYISEWEYNGQTISNIRVTTKVAVHCILSNCPQLKNIGSMILYNIAIKEVKTVVFDDIAVELAMAILQFFQSSPNEDQIFRTLRALVRFLEVSQDVPMIIQMIGPHPKQFAGKSERVDELIKIISRKVPA
InterPro domains: - IPR011989: Armadillo-like helical (homologous_superfamily) [26-291]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0003012 (muscle system process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0000793 (condensed chromosome)
Protein: Alanine dehydrogenase (EC 1.4.1.1) (P17557)
Organism: Geobacillus stearothermophilus (Bacillus stearothermophilus)
Function: Catalyzes the reversible reductive amination of pyruvate to L-alanine (Probable). A key factor in the assimilation of L-alanine as an energy source via the tricarboxylic acid cycle during sporulation (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0QVQ8}.
Sequence: MKIGIPKEIKNNENRVAITPAGVMTLVKAGHEVYVETEGGAGSGFSDSEYEKAGAADRCRTWRDAWTAEMVLKVKEPLAREFRYFRPGLILFTYLHLAAAERVTKAVVEQKVVGIAYETVQLANGSLPLLTPMSEVAGRMSVQVGAQFLEKPHGGKGILLGGVPGVRRGKVTIIGGGTAGTNAAKIGVGLGADVTILDINAERLRELDDLFGDHVTTLMSNSYHIAECVRESDLVVGAVLIPGAKAKLVTEEMVRSMTPGSVLVDIAIDQGGIFETTDRVTTHDDPTYVKHGVVHYAVANMPGAVPRTSTFALTNVTIPYALQIANKGYRAGCLDNPALLKGINTLDGHIVYEAVAAAHNMPYTDVHSLLHG
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [137-303]
- IPR007698: Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain (domain) [141-352]
- IPR008142: Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 (conserved_site) [4-30]
- IPR008143: Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 (conserved_site) [173-198]
- IPR008141: Alanine dehydrogenase (family) [1-371]
- IPR007886: Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal (domain) [4-137]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0042743 (hydrogen peroxide metabolic process), GO:0072593 (reactive oxygen species metabolic process), GO:0044248 (cellular catabolic process), GO:0042744 (hydrogen peroxide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex)
Protein: Chemokine-like protein TAFA-4 (Q96LR4)
Organism: Homo sapiens (Human)
Function: Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release.
Subcellular location: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:25109685}.
Sequence: MRSPRMRVCAKSVLLSHWLFLAYVLMVCCKLMSASSQHLRGHAGHHQIKQGTCEVVAVHRCCNKNRIEERSQTVKCSCFPGQVAGTTRAQPSCVEASIVIQKWWCHMNPCLEGEDCKVLPDYSGWSCSSGNKVKTTKVTR
InterPro domains: - IPR051743: TAFA chemokine-like (family) [8-140]
- IPR020350: Chemokine-like protein TAFA (family) [51-138]
Interaction partners: - Phosphatase and actin regulator 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0048662 (negative regulation of smooth muscle cell proliferation), GO:1904706 (negative regulation of vascular associated smooth muscle cell proliferation), GO:1904705 (regulation of vascular associated smooth muscle cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Hsp70/Hsp90 co-chaperone cns1 (O13754)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Co-chaperone that binds to the molecular chaperones Hsp90 and Hsp70. Stimulates Hsp70 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MAGFQSSEVDPNTKNKNAEEMFNELNKVPFFMQSLEDVGDESENNVQLDALKALAYEGEPHEVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIEIACYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKRVAQEKVIAAKTVLLALQERHIKTKTTEHPPDLGDAMISLSTFDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVFQSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPILKALTHPKVTLIDGLVQLHVVPHHLASDWISSWKKNKQENAKN
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [56-202]
- IPR044059: Cns1/TTC4, wheel domain (domain) [237-348]
- IPR019734: Tetratricopeptide repeat (repeat) [64-169]
Interaction partners: - Protein HGH1 homolog
- Small ribosomal subunit protein eS7
- Hsp90 co-chaperone Cdc37
- Heat shock protein sti1 homolog
- Chromatin structure-remodeling complex subunit snf21
- Heat shock protein 90 homolog
- 40 kDa peptidyl-prolyl cis-trans isomerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0031072 (heat shock protein binding), GO:0030544 (Hsp70 protein binding), GO:0051879 (Hsp90 protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0042026 (protein refolding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Rhamnogalacturonase A (RGase A) (RHG A) (EC 3.2.1.171) (P87160)
Organism: Aspergillus niger
Function: Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins.
Subcellular location: Secreted {ECO:0000250}.
Sequence: MPALPILALALAPLLVNGQLSGSVGPLTSAHSKAATKTCNVLDYGAVADNSTDIGSALSEAWDACSDGGLIYIPPGDYAMDTWVSLSGGKATAIILDGTIYRTGTDGGNMILVENSSDFELYSNSSSGAVQGFGYVYHREGDLDGPRILRLQDVSNFAVHDIILVDAPAFHFVMDDCSDGEVYNMAIRGGNSGGLDGIDVWGSNIWVHDVEVTNKDECVTVKGPANNILVESIYCNWSGGCAMGSLGADTDITDILYRNVYTWSSNQMYMIKSNGGSGTVNNTLLENFIGRGNRYSLDVDSYWSSMTAVDGDGVQLSNITFKNWKGTEADGAERGPIKVVCSDTAPCTDITIEDFAMWTESGDEQTYTCESAYGDGFCLEDSDSTTSYTTTQTVTTAPSGYSATTMAADLTTDFGTTASIPIPTIPTSFYPGLTAISPLASAATTA
InterPro domains: - IPR000743: Glycoside hydrolase, family 28 (family) [144-370]
- IPR012334: Pectin lyase fold (homologous_superfamily) [19-441]
- IPR024535: Rhamnogalacturonase A/B/Epimerase-like, pectate lyase domain (domain) [39-84]
- IPR011050: Pectin lyase fold/virulence factor (homologous_superfamily) [19-439]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016837 (carbon-oxygen lyase activity, acting on polysaccharides)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0005976 (polysaccharide metabolic process), GO:0010393 (galacturonan metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0045488 (pectin metabolic process), GO:0045490 (pectin catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)