wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Mitochondrial pyruvate carrier 1-like protein (P0DKB6)
Organism: Homo sapiens (Human)
Function: Mediates the uptake of pyruvate into mitochondria
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MARMAVLWRKMRDNFQSKEFREYVSSTHFWGPAFSWGLPLAAFKDMKASPEIISGRMTTALILYSAIFMRFAYRVQPRNLLLMACHCTNVMAQSVQASRYLLYYYGGGGAEAKARDPPATAAAATSPGSQPPKQAS
InterPro domains: - IPR005336: Mitochondrial pyruvate carrier (family) [16-110]
Interaction partners: - Mitochondrial pyruvate carrier 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport), GO:0006848 (pyruvate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Mitochondrial pyruvate carrier 2 (O95563)
Organism: Homo sapiens (Human)
Function: Mediates the uptake of pyruvate into mitochondria
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein
Sequence: MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK
InterPro domains: - IPR005336: Mitochondrial pyruvate carrier (family) [28-124]
Interaction partners: - Mitochondrial pyruvate carrier 1
- Mitochondrial pyruvate carrier 1-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport), GO:0006848 (pyruvate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Methylsterol monooxygenase 1 (Q7ZW77)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MEVNGTANILSSAFLAVEFVDSFLPQNPLQEPFKHAWNHMLQNYTKFQIATWGSLIVHELIYFLFCLPGFIFQFLPFMQKYKIQPDKPETWEKQWKCFKMLLFNHFCIQLPLICGTYYFTEFFSIPYDWDTMPRWPFLLAQCFGCAVIEDTWHYFLHRALHHRRIYKYIHKVHHDFTSPFGMQAEYAHPLETLILGAGFFIGTMVFCNHMILLWAWVTFRLLETIDVHSGYDIPLNPLHLIPFYAGARFHDFHHMNFVGNYGSTFTWWDRLFDTDSQFNKHYSHHKTAKSD
InterPro domains: - IPR006694: Fatty acid hydroxylase (domain) [144-274]
- IPR050307: Sterol Desaturase and Related Enzymes (family) [44-280]
Interaction partners: - 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Lanosterol 14-alpha demethylase
- Hydroxymethylglutaryl-CoA synthase
- Squalene synthase
- 7-dehydrocholesterol reductase
- isopentenyl-diphosphate Delta-isomerase
- Acyl-CoA 6-desaturase
- Sigma non-opioid intracellular receptor 1
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- Diphosphomevalonate decarboxylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016716 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Meiotically up-regulated gene 183 protein (Q92348)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis
Sequence: MESNVNDEIEKAFAKDSELAKDIIKQYGKTKSIQPLVHRICKYINTLQKENESGQVKEAGSLKRKDRVQHELGQLVYGVLNLSFQAPMRKKLDVYIYENGIAVTLPGEPNLIEFWLPWNEIRCAIHVPCPRKANVQNNFVIILKSESSAENIVSSDNVKEPVFFTAPYPLKKLNLVEGLRSFTHCTNSWDIFRDYFEFIGTSTLSPSVEEFVCPNPQTGDNGTTYGVEANYKAKDGHLFFLRTGILWGFRKPILFIELASIQHFSYSNVLQRTFTVNFEAGGTIYSFDMVDQSVFRAVNDYATKHGLMDSSLAEEKAAPVPKNPSVSYLNEASSLENVDDMDDIDVKEPLFSDNDEDVENSDSEDGSESIGSEDEE
InterPro domains: - IPR013719: Histone chaperone RTT106/FACT complex subunit SPT16-like, middle domain (domain) [224-312]
- IPR050454: RTT106/SSRP1 Histone Chaperone/FACT Complex (family) [62-374]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [215-306]
Interaction partners: - Putative box C/D snoRNA protein SPCC613.07
- Chromatin assembly factor 1 subunit B
- Chromatin assembly factor 1 subunit A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140104 (molecular carrier activity), GO:0140597 (protein carrier chaperone), GO:0140713 (histone chaperone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006335 (DNA replication-dependent chromatin assembly), GO:0006338 (chromatin remodeling), GO:0071824 (protein-DNA complex subunit organization), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0034728 (nucleosome organization), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization), GO:0140719 (constitutive heterochromatin formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: Diphosphomevalonate decarboxylase (Q5U403)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the ATP dependent decarboxylation of (R)-5- diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis
Subcellular location: Cytoplasm
Sequence: MSENILQDLEMVTCTAPVNIAVIKYWGKRDEDLILPVNASLSVTLHQDHLRTTTTIACSRSFHKDCIWLNGKEQDISHPRLQSCLLEIRRLAQRRKNTGDPASDVSNKVHICSVNNFPTAAGLASSAAGYACLVYTLSQLFNVEGELSGVARQGSGSACRSLYGGFVQWKLGEQSDGKDSIAEQVASELYWPELRVLILVVSAEQKSVGSTSGMHTSVETSHLLKYRADAVVPGRMEEMIRAIRLRDFPKFGELTMKDSNQFHAICLDTYPPIFYLNNISHQIISLVHRYNQYYGETRVAYTFDAGPNAVIYSLQDYLPEFVEVVRHFFPPEVNEEEFFKGLPVCPADLSEEMIRDINMKPTPNGIRYMISTKAGPGPRVVEDPNLHLLGADGLPKKSAV
InterPro domains: - IPR005935: Diphosphomevalonate/phosphomevalonate decarboxylase (family) [8-385]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [11-192]
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [12-186]
- IPR029765: Diphosphomevalonate decarboxylase (family) [13-328]
- IPR036554: GHMP kinase, C-terminal domain superfamily (homologous_superfamily) [187-384]
- IPR053859: Diphosphomevalonate decarboxylase-like N-terminal domain (domain) [16-182]
- IPR041431: Mvd1, C-terminal (domain) [196-381]
Interaction partners: - isopentenyl-diphosphate Delta-isomerase
- Geranylgeranyl pyrophosphate synthase
- Hydroxymethylglutaryl-CoA synthase
- (S)-2-hydroxy-acid oxidase
- Lanosterol 14-alpha demethylase
- RUS family member 1 isoform X1
- Squalene synthase
- Methylsterol monooxygenase 1
- 7-dehydrocholesterol reductase
- All trans-polyprenyl-diphosphate synthase PDSS1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Transcriptional regulator Myc-B (Q7ZVS9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes
Subcellular location: Nucleus
Sequence: MPLNSSMECKNYDYDYDSYQPYFYFDNEDEDFYNHQHGQPPAPSEDIWKKFELLPTPPLSPSRRPSLSDPFPSTADKLEMVSEFLGDDVVNHSIICDADYSQSFLKSIIIQDCMWSGFSAAAKLEKVVSERLASLQAARKESSRTESADICRSVGFLQDMSTPASQCIDPSVVFPFPLTDSTKPCKPAPTPASTTLPLDTPPNSGSSSSSSDSESDDEDDEDEEEEEEIDVVTVEKRKSVKKSDANATHQSPVVLKRCHVNIHQHNYAAHPSTRNEQPAVKRIKFESHIRVFKQISHNRKCASPRTSDSEDNDKRRTHNVLERQRRNELKLSFFALRDVIPDVANNEKAAKVVILKKATECIASMQEDEQRLISLKEQLRRKCEHLKQRLEQLSCS
InterPro domains: - IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [305-396]
- IPR002418: Transcription regulator Myc (family) [1-394]
- IPR003327: Leucine zipper, Myc (domain) [367-396]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [313-371]
- IPR012682: Transcription regulator Myc, N-terminal (domain) [2-304]
- IPR050433: Myc family transcription factors (family) [7-393]
Interaction partners: - Mitogen-activated protein kinase
- Transcriptional regulator Myc-A
- Protein max
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Myoneurin (Q7ZVR6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MPHITHSEFLLEQLKRQRERSFLCDCTVSIGQAQYRAHHNVLAAFSEYFSTQSVDAGREDPTITLDPESVSSAIFEKLLTYIYTGDLNMDREEIESVQKAASYLGMPEVVARCTLSQDNIKNVGSPMRQAEYEDPRSPLSPDDYEPLEPISEVEERELLREDRAGDDLVSMDEAQSSSEQTPQRVGKRGRKPKTRLYEDEFEVETISAQRGRGRGRGRPRGRPRVRPLSSDSTDQSPAHQAMSPNGSSTSRGSGRPRGRPRVRPLSTANEDPRNVEDDPAANKDQEVEKGNEEQKKETGEKDDGKNDTDNPEEVTAFKRGRGRPRIKPVSTEDQTTNSENVTTNAEDGSEPAKTKDSEGTGRKRGRPRSKPVSSEDPESVISVEISGEEAGEETSQDAEKHTEEGTEDSESNPGNSVRISKRKRILSRKLKESQAGDEEEEEEEEMDDEFENDNEDWAGEEEVKPVQDKHRPICNICGNLFSEMSSLRRHMRIHKGLKPYQCTLCTRSFRQGNQLKTHMRIHTGEKPFTCTSCDSRFAQKCQLVYHCRMHHGEEKPYKCEFCGAAFATSSNLKIHIRKHSGEKPYECGECGKRFTQASTLMYHKRRHTGEKPYICDTCGMAFAVSSSLIAHNRKHTGVTPYICLDCGKPCLTAGELRKHMDVHNDIYSLKKHSILKHNVVPELETTQTSKTDPTQCPLNIPIDHQGLIARVRSALVDSQDHEIQMEPPLPILPPETSLTIQQSAEPQMIIQHADGSEPSMIFQHAEASEAPMLIQHGEPGEQVSYVVEQYEIPATAEMEHTQIVIVQTID
InterPro domains: - IPR017956: AT hook, DNA-binding motif (conserved_site) [213-369]
- IPR000637: HMG-I/HMG-Y, DNA-binding, conserved site (conserved_site) [315-326]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [1-134]
- IPR000210: BTB/POZ domain (domain) [14-121]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [473-659]
- IPR013087: Zinc finger C2H2-type (domain) [472-668]
Interaction partners: - Rhophilin-2
- Dual specificity protein phosphatase 10
- Protein phosphatase 1B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Modulator protein MzrA (P42615)
Organism: Escherichia coli (strain K12)
Function: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR
Subcellular location: Cell inner membrane; Single-pass membrane protein
Sequence: MQIPRMSLRQLAWSGAVLLLVGTLLLAWSAVRQQESTLAIRAVHQGTTMPDGFSIWHHLDAHGIPFKSITPKNDTLLITFDSSDQSAAAKAVLDRTLPHGYIIAQQDNNSQAMQWLTRLRDNSHRFG
InterPro domains: - IPR026574: Modulator protein MzrA (family) [2-116]
- IPR027398: SecD export protein N-terminal TM domain (domain) [17-105]
Interaction partners: - Inner membrane protein YqjA
- Sensor histidine kinase EnvZ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051338 (regulation of transferase activity), GO:0051246 (regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0043549 (regulation of kinase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: NEDD4-binding protein 3 (O15049)
Organism: Homo sapiens (Human)
Function: Plays a positive role in the antiviral innate immune signaling pathway. Mechanistically, interacts with MAVS and functions as a positive regulator to promote 'Lys-63'-linked polyubiquitination of MAVS and thus strengthens the interaction between MAVS and TRAF2. Also plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage (By similarity)
Subcellular location: Cytoplasmic vesicle. Cell projection, axon. Cell projection, dendrite. Note=In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites
Sequence: MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQREFLSYLHLPKKDSKSTKNTKRAPRNEPADYATLYYREHSRAGDFSKTSLPERGRFDKCRIRPSVFKPTAGNGKGFLSMQSLASHKGQKLWRSNGSLHTLACHPPLSPGPRASQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHLNHLGGSLDRASQGPKEAGPPAVLSCLPEPPPPYEFSCSSAEEMGAVLPETCEELKRGLGDEDGSNPFTQVLEERQRLWLAELKRLYVERLHEVTQKAERSERNLQLQLFMAQQEQRRLRKELRAQQGLAPEPRAPGTLPEADPSARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELVRLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGSEARDSAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQALEQELRALREPPTPWSPRLESSKI
InterPro domains: - IPR033571: NEDD4-binding protein 3 (family) [9-544]
Interaction partners: - E3 ubiquitin-protein ligase NEDD4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: N-alpha-acetyltransferase 40 (Q9USH6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A
Subcellular location: Cytoplasm. Nucleus
Sequence: MHFLKQYLFYSPRRMKTQEIKNVTLEDVDFLKNLGVWVEIYHHLEKGLLQQCFNLVKKNMEALYRQSSFGWDDSEKLKEMEMEKLEYICIFEKTSKKLVGFLSFEDTVEAGLTCLYIYEIQLDEHIRGRNVGKWLLKNASILAYRRNLKYIFLTVFSANLNALNFYHHFDFVPHESSPQEKKFRSGKVIHPDYYILYTKSRKDW
InterPro domains: - IPR039949: N-alpha-acetyltransferase 40 (family) [36-199]
- IPR000182: GNAT domain (domain) [39-202]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [49-179]
Interaction partners: - Uncharacterized N-acetyltransferase C663.13c
- N-terminal acetyltransferase B complex catalytic subunit naa20
- N-alpha-acetyltransferase 30
- N-terminal acetyltransferase A complex catalytic subunit ard1
- N-terminal acetyltransferase B complex subunit arm1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity), GO:0004596 (peptide alpha-N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0051604 (protein maturation), GO:0010467 (gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0032153 (cell division site), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)