Protein: Protein ENDOPLASMIC RETICULUM-ARRESTED PEN3 (Protein ER-ARRESTED PEN3) (Q9S7R7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Confers resistance to soil-born pathogens (e.g. the root-penetrating fungus Fusarium oxysporum) by regulating membrane trafficking, specifically mediating ABCG36/PEN3 exit from the endoplasmic reticulum and subsequent relocalization at the host-pathogen interface of the plasma membrane.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:29085068}.
Sequence: MVVSDGGKRVKLNVGGEIFETNASTIQSSCPDSLLAALSTSTSHGSNPVFIDRDPEIFAVILNLLRTGRLPANSSGVFSKQELLDEAMYYGVESLLRLAMLPPPLLGFDASLVSTIVPAADGVPSALTATAGDASLWIAHGGQISVYDWSLSHAGTVRTHLNDITSICRVWGEAAAIGSGSASGLHFYDLSGGRYIGSTHWTDPEDPRIHKARVAAVADSEGGVFASFDCLHRENSVLQIDKSTLQVAAVIGQQSGNSAKTTVPEKLRWLPAKGLLVGSAVQRGVFGCSGYIRIWDPRSRNIVWETNEPGSGRSTRFGDALADMDVDVEDSILFKVCSKSGDLGMADIRKLGEDPWVYMSDENPGAWKAGDGGGYSVVHCYRKQVLAARGGALEVWSSVKEKTSGDPIRRRNFVDKEDDSKRGMISKIEAGGDRLFVSRECMEGVEVWETSSFSGVVSVE
InterPro domains: - IPR057441: At2g24240-like, C-terminal beta-propeller (domain) [132-450]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [10-95]
- IPR000210: BTB/POZ domain (domain) [8-107]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [7-100]
- IPR011044: Quinoprotein amine dehydrogenase, beta chain-like (homologous_superfamily) [115-314]
- IPR045068: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-3 (family) [8-455]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0044248 (cellular catabolic process), GO:0070482 (response to oxygen levels), GO:0019538 (protein metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0071456 (cellular response to hypoxia), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071453 (cellular response to oxygen levels), GO:0044265 (cellular macromolecule catabolic process), GO:0033993 (response to lipid), GO:0036293 (response to decreased oxygen levels), GO:0030163 (protein catabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0036294 (cellular response to decreased oxygen levels), GO:2001141 (regulation of RNA biosynthetic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0006355 (regulation of DNA-templated transcription), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)