Protein: Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1) (Q3SZX0)
Organism: Bos taurus (Bovine)
Function: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity).
Subcellular location: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.
Sequence: MASLSHILVLCVGLLAMVNAEAPQEHDPFTYDYQSLRIGGLIIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
InterPro domains: - IPR047281: Phospholemman (family) [23-86]
- IPR000272: Ion-transport regulator, FXYD family (family) [25-70]
- IPR047297: Ion-transport regulator, FXYD motif (conserved_site) [27-40]
Interaction partners: - Sodium/potassium-transporting ATPase subunit alpha-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0016247 (channel regulator activity), GO:0099106 (ion channel regulator activity), GO:0017080 (sodium channel regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0051049 (regulation of transport), GO:0032409 (regulation of transporter activity), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0034762 (regulation of transmembrane transport), GO:0060255 (regulation of macromolecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043462 (regulation of ATP-dependent activity), GO:0051246 (regulation of protein metabolic process), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0051248 (negative regulation of protein metabolic process), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:1903406 (regulation of P-type sodium:potassium-exchanging transporter activity), GO:0031399 (regulation of protein modification process), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0031400 (negative regulation of protein modification process), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:1901016 (regulation of potassium ion transmembrane transporter activity), GO:0043266 (regulation of potassium ion transport), GO:0002028 (regulation of sodium ion transport), GO:1902305 (regulation of sodium ion transmembrane transport), GO:2000649 (regulation of sodium ion transmembrane transporter activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)