Protein: Ammonium transporter Rh type A (Q9QUT0)
Organism: Mus musculus (Mouse)
Function: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Heterotrimer with RHCE (RHAG)2(RHCE), that transports ammonium and its related derivative methylammonium, in both neutral and ionic forms, across the erythrocyte membrane. The transport of NH4(+) is electrogenic and masks the NH3 transport. Also, may act as a CO2 channel. Moreover in erythrocyte, regulates RHD membrane expression and is associated with rhesus blood group antigen expression (By similarity)
Subcellular location: Membrane; Multi- pass membrane protein. Note=Localization at the plasma membrane is regulated by ANK1
Sequence: MRFKFPLMAISLEVAMIVLFGLFVEYETPQNASQKNASHQNASQQGNTSSSAKKDQFFQLYPLFQDVHVMIFVGFGFLMTFLKKYGFSGVGFNLFLAALGLQWGTIMQGLLHSHGKEFHFGIYNMINADFSTATVLISFGAVLGKTSPIQMLIMTILEIAVFAGNEYLVTELFEASDTGASMTIHAFGAYFGLAVAGVLYRPGLRCEHPNDESVYHSDLFAMIGTLFLWIFWPSFNSAIADPGDHQYRAIVNTYMSLAACVITAYALSSLVERRGRLDMVHIQNATLAGGVAVGTCADMEIPLYAAMTIGSIAGIISVLGYKFFSPLLANKLMIHDTCGVHNLHGLPGVFGGLASIVAISWGMSTASMAMQAAALGSSIGSAIVGGLLTGLILKLPIWNQPPDEYCYDDSVSWKVPKFRELDNRFFQHANHNHVEHEV
InterPro domains: - IPR029020: Ammonium/urea transporter (homologous_superfamily) [1-418]
- IPR002229: Blood group Rhesus C/E/D polypeptide (family) [4-401]
- IPR024041: Ammonium transporter AmtB-like domain (domain) [50-410]
Interaction partners: - Protein 4.2
- Band 3 anion transport protein
- Blood group Rh(D) polypeptide
- Ankyrin-1
- Glycophorin-A
- Spectrin alpha chain, erythrocytic 1
- Kell blood group glycoprotein homolog
- Erythroid membrane-associated protein
- Aquaporin-1
- Ankyrin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015267 (channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008519 (ammonium transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048878 (chemical homeostasis), GO:0048856 (anatomical structure development), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0034101 (erythrocyte homeostasis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098771 (inorganic ion homeostasis), GO:0140962 (multicellular organismal-level chemical homeostasis), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0098662 (inorganic cation transmembrane transport), GO:0071705 (nitrogen compound transport), GO:0055080 (monoatomic cation homeostasis), GO:0030218 (erythrocyte differentiation), GO:0030099 (myeloid cell differentiation), GO:0055072 (iron ion homeostasis), GO:0061515 (myeloid cell development), GO:0048821 (erythrocyte development), GO:0072488 (ammonium transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)