wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: DBIRD complex subunit ZNF326 (Zinc finger protein 326) (A0A0A0MRN4)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
Sequence: MDFEDDYTHSACRNTYQGFNGMDRDYGPGSYGGMDRDYGHGSYGGQRSMDSYLNQSYGMDNHSGGGGGSSFSSPHMKPAPVGSRGRGTPAYPESTFGSRNYDAFGGPSTGRGRGRGHMGDFGSIHRPGIVVDYQNKSTNVTVAAARGIKRKMMQPFNKPSGTFIKKPKLAKPMEKISLSKSPTKTDPKNEEEEKRRIEARREKQRRRREKNSEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESSSHQETLDHIQKQTKFDKVVMEFLHECMVNKFKKTSIRKQQTNNQTEVVKIIEKDVMEGVTVDDHMMKVETVHCSACSVYIPALHSSVQQHLKSPDHIKGKQAYKEQIKRESVLTATSILNNPIVKARYERFVKGENPFEIQDHSQDQQIEGDEEDEEKIDEPIEEEEDEDEEEEAEEVGEVEEVEEVEEVREGGIEGEGNIQGVGEGGEVGVVGEVEGVGEVEEVEELEEETAKEEPADFPVEQPEEN
InterPro domains: - IPR034736: Zinc finger C2H2 AKAP95-type (domain) [225-341]
- IPR007071: A-kinase anchoring protein 95 (AKAP95) (family) [71-488]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0019899 (enzyme binding), GO:0005521 (lamin binding), GO:0003723 (RNA binding), GO:0042826 (histone deacetylase binding), GO:0017151 (DEAD/H-box RNA helicase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0043484 (regulation of RNA splicing), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032784 (regulation of DNA-templated transcription elongation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0140535 (intracellular protein-containing complex), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Lipid phosphate phosphatase epsilon 2, chloroplastic (AtLPPE2) (EC 3.1.3.-) (Phosphatidic acid phosphatase epsilon 2) (Plastidic phosphatidic acid phosphatase epsilon 2) (Q6NQL6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Exhibits phosphatidate phosphatase (PAP) activity in vitro. May play a secondary role as PAP in plastids.
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000305|PubMed:17652095}; Multi-pass membrane protein {ECO:0000305|PubMed:17652095}.
Sequence: MAASSSSLLLLHKPTYNFHFAASSVPTYINSARFRISSSIFPLDRRRRRRIWSVSGFKSMADLVKTNARRDGEDRFQALEQEAFISNSSSELQNELVSDAGDGIEAIANRLSKWIVAALFGSVLLLRHDGAALWAVIGSVSNSVLSVALKRILNQERPVATLRSDPGMPSSHAQSISFISVFSVFSVMEWLGTNVLSLFLSGFILALGSYFTWLRVSQKLHTTSQVVVGAIVGSVYSTLWYVTWNSLVLEAFTSTFSVQIALFLVAAASALGFAVYVLLNWFKDDR
InterPro domains: - IPR039667: Dolichyldiphosphatase, PAP2 domain (domain) [99-241]
- IPR036938: Phosphatidic acid phosphatase type 2/haloperoxidase superfamily (homologous_superfamily) [102-245]
- IPR000326: Phosphatidic acid phosphatase type 2/haloperoxidase (domain) [132-241]
Interaction partners: - Lipid phosphate phosphatase gamma
- Lipid phosphate phosphatase 1
- Lipid phosphate phosphatase 2
- Putative lipid phosphate phosphatase 3, chloroplastic
- Mediator of RNA polymerase II transcription subunit 6
- Phosphatidate phosphatase PAH1
- Mediator of RNA polymerase II transcription subunit 14
- Mediator of RNA polymerase II transcription subunit 31
- Mediator of RNA polymerase II transcription subunit 23
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0008195 (phosphatidate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006638 (neutral lipid metabolic process), GO:0046460 (neutral lipid biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0046463 (acylglycerol biosynthetic process), GO:0006639 (acylglycerol metabolic process), GO:0046339 (diacylglycerol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] (EC 2.5.1.87) (Q8H0V2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Sequence: MDSNQSMRLLSAWIGQIGDLGLNLLWRFIHIVVSLWYIVSGIFEAIESYAITLGLNKKYGSIDLEKLRCLAVVVDIEAAQDVANVVELLQWLTTIGVKQVGLFDSQGLLKKSKDLILETVPGSMLLEEIEKDVAPDGKRIALEFISSSDNKEAVMKAANILLQRYLKSSHPEDDKGEDFFTESHLNDALRVVGENVHVPDLLLVYGPIRSHLGFPAWRLRYTEIVHMGTLKYMRYGSLLKAIHKFTGVHQNYGT
InterPro domains: - IPR038887: Dehydrodolichyl diphosphate synthase complex subunit Nus1 (family) [12-254]
- IPR036424: Decaprenyl diphosphate synthase-like superfamily (homologous_superfamily) [68-254]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0008654 (phospholipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (Q96NI6)
Organism: Homo sapiens (Human)
Function: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MEKILFYLFLIGIAVKAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLETCASPPLLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKLPHLLNSTNHIHEPDPGSSDISTSTKSGSNTSSSNGDTKLSQDKIVVAEATSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLAAGTMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQIQGCSVTLPQSVSKQAVGHEENAQCCKATSDNVIQSSETCSSQDSSTTTSALPPSWTSSTSVSQKQKRKTGTKPSTEPQNEAVTNVESQNTNRNNSTALQLASRPPDSVTEGPTSKRAHIKPNALLTNVDQIVQETQRLELI
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [20-286]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [422-495]
- IPR050467: Leucine-rich repeat and fibronectin type-III domain-containing (family) [8-649]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [284-374]
- IPR013098: Immunoglobulin I-set (domain) [289-374]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [287-518]
- IPR007110: Immunoglobulin-like domain (domain) [287-373]
- IPR003598: Immunoglobulin subtype 2 (domain) [299-364]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [74-218]
- IPR001611: Leucine-rich repeat (repeat) [99-213]
- IPR003599: Immunoglobulin domain subtype (domain) [293-375]
Interaction partners: - Receptor-type tyrosine-protein phosphatase delta
- Receptor-type tyrosine-protein phosphatase S
- Disks large homolog 4
- Receptor-type tyrosine-protein phosphatase F
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: fructose-bisphosphatase (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (Q38EA4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MPDYSRVPSTLMQFLMHNQPKGSRGAFTLLMMAIQTSVKVIEMNIRSAGAQGLFGHLNDGRANATGDEQAKLDVVANNAFKAYLMSSASVSFMGSEEDESIVVVSSGQQGDYVVFFDPLDGSSNIDANISIGSVWGIWCLPKGTKVRTTKDALKVLPRLSGRYLVSSGYAMYGTATNLVITTGSGVNGFTLDTTVGEFIHTHPNITLPQSRPIYSVNEGNLRHWDAWFKQYLHHIKNEGEKAYTARYIGSMVADIHRTLLYGGIFCYPGDKKKPGGKLRLMYEAAPMAFLIEQAGGLALTGDGRLLDVVPKEIHQRAPVFMGSRREVELCMSFKQKYNDRGGVQRERSKL
InterPro domains: - IPR028343: Fructose-1,6-bisphosphatase (family) [6-339]
- IPR044015: Fructose-1-6-bisphosphatase class 1, C-terminal (domain) [208-333]
- IPR033391: Fructose-1-6-bisphosphatase class I, N-terminal (domain) [10-203]
- IPR000146: Fructose-1,6-bisphosphatase class 1 (family) [6-340]
Interaction partners: - Transketolase
- Transaldolase
- Fructose-bisphosphate aldolase
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Phosphotransferase
- Phosphotransferase
- mannose-6-phosphate isomerase
- Ribulose-phosphate 3-epimerase
- Phosphomannomutase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043168 (anion binding), GO:0042301 (phosphate ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0019318 (hexose metabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0016051 (carbohydrate biosynthetic process), GO:0006006 (glucose metabolic process), GO:0019319 (hexose biosynthetic process), GO:0006094 (gluconeogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0020015 (glycosome)
Protein: Putative amidase C550.07 (EC 3.5.1.4) (O59805)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MTIDWRQIAAKYCAHRDGSIPEPFKIKTLPKDTVLNVTKIPSECGLLTPKEIELTEKYDATALAEMIKDRKVTSVELVTAFCKRAAIAQQLVNCVNELFYEEALARAAELDEYYAKTGSLVGPLHGVPVSVKEHISIKNHTATASFLAKANIIAEKDSDLVATVRKAGAVFYCRTPQPQAIMHLETSSNLTGVTVNPFNRKLTPGGSSGGEGALLGIKASVLGIGSDIGGSIRSPAANNGLFGLRPSTLRLSRKGCQGAVSGQETILGVVGPLGRSVRDMNLFMKACIDSQPWLDDASLLPMPWRSVAPPKTLKVGIMRSDNVVNPQPPVARAMQMAIDQLSKNPDFDLVDVEPLDHKYSWDLISEMYWLDGGKVYYDLFNKVGEPILPLTEWIMHQPNVKPHDITAVWKLTAARDEYRNRYLKHLQAYGVDVLLTPVGPSPAPKLGEAKYWTYTSVWNLLDLPAVVFPVTTVDPKLDVKDESYIPMNEQDAANYETYSPEDYLDAPVSLQLVGKRWQDEELLAALDKIVSML
InterPro domains: - IPR036928: Amidase signature (AS) superfamily (homologous_superfamily) [27-533]
- IPR023631: Amidase signature domain (domain) [76-523]
- IPR020556: Amidase, conserved site (conserved_site) [205-236]
Interaction partners: - Putative aldehyde dehydrogenase-like protein C922.07c
- Putative aldehyde dehydrogenase-like protein C9E9.09c
- Putative amidase C869.01
- Putative amidase PB8B6.03
- Glutamyl-tRNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0044282 (small molecule catabolic process), GO:0043605 (amide catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Alpha box domain-containing protein (G5EAT5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU003516}.
Sequence: MENALSPLQRAFNAFLLSMPPQQLDDLVKHIQDVKAQEQKPPVFRNEIPAIRANTTQDAHHTFPTFPSSKHRPASSRGRRVHDGKRRPLNSFIAFRSFYSAIFPDITQKSKSGILRFLWQNDPFKAKWTILAKAYSIIRDKHDDEVSLESFLTLNAELIGVTQPDRYLDAMGWELTLNDQQQYTMARVKSPVATEAQLSTHFSVDDLIKHCYATGYVTEDKRKKEIRGHNAPVMTFATQPALVIHKNNSLQISGNHTVVSTNGSESVTKETPAFEPTEATELPYPSDIVSPVTGDTSFESTDATRIYQRPQSRTSLAENYLDMANMQFHTWDDQTALLPYNTGPLMQESFDALDFKPFLNI
InterPro domains: - IPR006856: Mating-type protein MAT alpha 1, HMG-box (domain) [73-222]
Interaction partners: - MAT2 proteinMating type HMG-box protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0003006 (developmental process involved in reproduction), GO:0000909 (sporocarp development involved in sexual reproduction), GO:0048731 (system development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0048608 (reproductive structure development), GO:0080090 (regulation of primary metabolic process), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0009891 (positive regulation of biosynthetic process), GO:0061458 (reproductive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0008406 (gonad development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0008585 (female gonad development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: TBC1 domain family member 7 (Q385K7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004656}.
Sequence: MKGDDSVHGDATTDLQSPREDVVTMASDGDHMIRKSLKDSNSDAPIFGELLDAEVTVNPMKLREASRAGIPPLYRSAVYRYLLGVSFVDKSREMTVERMQEKDFEQLEATFAQIVACDEKGGSTRCHASHALFAANCDTMMTRRESKFVNGYRCSDRFSTFGCTTWLAVLARLKYMPQFVGNHERRQRIESAWRALYVCHSEATPDEVNYIFELAIAFEAVYSTARDIYFSVESIYHLLTHHNNVLQNKQCLQHHCGVFLMLFRATNFELYRHFVTEGVSVLDWVPGILTTLLAGRLHVEDLLRLWDVYFADAQNCLGFPLHPYVCLAILAEMTEVLIECEKSGIIELLQNMPRMRMGCIIQRAIALKESVLSQGLL
InterPro domains: - IPR035969: Rab-GAP-TBC domain superfamily (homologous_superfamily) [55-369]
- IPR000195: Rab-GAP-TBC domain (domain) [216-332]
- IPR039842: TBC1 domain family member 7 (family) [65-369]
Interaction partners: - Small GTP-binding protein Rab1, putative
- Small GTP-binding protein RAB6, putative
- Vacuolar protein sorting 33, putative
- AP-3 complex subunit delta
- Phosphoinositide-binding protein, putative
- Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0007264 (small GTPase mediated signal transduction), GO:0007265 (Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0020015 (glycosome)
Protein: Magnesium transporter MRS2 homolog, mitochondrial (MRS2-like protein) (Q9ET09)
Organism: Rattus norvegicus (Rat)
Function: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits.
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9HD23}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD23}.
Sequence: MECLRYLPRLLPRAAQSRSALCMAAVRLSLAACCGRATPLTSGSQKAPSTPRTAGDVYRFRTSDASQATLASVAQVFAVTKFDKEGNVTSFERKKTELYHELALQARDLRFQHVMSITTRNNRIIMRMEYLKAVITPEYLLILDYRNLNLEHWLFRELPSQLAGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHVLLQNGKSLSELETDIKIFKESILELLDEEEMLEELCLTKWSDPHVFEQSSTGIDHAEEMELLLENYYRLADDLSNEARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRVFWLITGIMFMGSGLIWRRLLSFLGRQLEAPLPPVMASLPKKTLLADRRMDVKNSLRPEGLGAGRTILASR
InterPro domains: - IPR039204: Magnesium transporter MRS2-like (family) [62-390]
Interaction partners: - Solute carrier family 41 member 3
- Insulin receptor-related protein
- Solute carrier family 41 member
- Solute carrier family 41 member
- ER membrane protein complex subunit 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015078 (proton transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1990542 (mitochondrial transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0015693 (magnesium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)