Protein: FEEL-1 (E0CZJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MSYLLVLGLTVLWTAQIQAVVNRCDTPVMVLHRTSCTSCAAASAIVCPRGSKKVTKTPDSCRYVVEIGGRQVELSGCSHTCQQVTTVQQCCPGFWGPLCLPCPSWSGKICNGFGTCESGLSGNGTCVCEEGYAGFACQNCLNENAYGSHCLSECSCVNGKCNSGPDGDGKCYCQPPYIGPKCDKVSSSCSSCPLYSYCKGDDDTNAVCECLPGNKFGQACLDVCPEGTCGINAKCLSKDDKYNCECKEGFEGDGKHCIPINPCKTNNGDCPVTSTTCELISPGKSKCVCLPGMESSDPSKGCTQKSACTASSCHTSARCETNGDGSPRCRCGSQQIGDGRRCYGNLMERVVELDREGSQAGNLTGSVRFFEQACEFTLSQHGPFTAFIPAGQNPFQTLAGQSSSSILNTVCKNHLILGQKLYSVLEGKDMWMYGGEKIRFKTNKHFILMRDPDVLFTIVESDIPASNGIIHIIDKPFTLTHIESSNNNMEFSTKTISDIFREDDRFNRFLSLVDNCGALLPFRGTGPLTVLVPTNTAIDKFRDGSLMYMLNDAKPKLQTLLKHHIFSLAAITVDQLASMSEITTMANEILRINASDDGRIFLGDKGITLETKDIIASNGIIHLINGVLVPSSIVPIMPHRCDVNSSRISFGSCVRCSHLYETKCPPGSVELPGRHEGCEPLPDRRFSYSIFEEGCAKYCNITETSPQCCRGFYGPDCKPCIGGFQNPCYGKGTCFDGINGNGSCKCEAAFTGVGCHLCSNPKKHGENCDEDCRCVHGVCDNRPGSSGVCRRGSCFEGFLGELCDQTASVCDSDGALLHCHIHAICLYVKGQTTCVCQPGYEGDGYACTESNPCLLPQRGGCDTNAVCSYNAGKVNCVCMEGWTGDGSLCVEINNCQLESRGGCHENADCTSTAPGQNECSCKKGYMGDGIICKIVNPCLSDNGGCHSLAKCKLTSPGTRECTCPSEFEGDGLSCYGNMLVELDGNSEFYYFNRFLQRHKVIETDSQVTALVPSKAAFKNLSDLEESFWFDYYRLPHLLQVHFLEGIYTSEDLRQKAGKTVQTIGMTKWEVQSNGRELMISNATILVPDIKAINGCIHIIDTVLRPPLSDFPPPPPTLMKFLNNTPEFSLFRQAALLYNLENSIPTRDYTILIPYDSAVQEYLIKTNATQLSKEIVKYHVILSEQLFPEHLSDRLFKNTFLGNGTQIMFFVDIENQIIANDVPVNMSYIETRHGIVFGIPRVLDLHKNHCSKDVILKITGRCGDCKAAPQCPFSAKPTQPKFPQNMKSNCKYRTRVGKKRKTVSGCLMDCLRTTKDHSCCPGYFGHDCGKCPGTLDNWCSNNGQCEDGLHGTGKCLCNEGFHGTACEMCEPGRYGKDCKSECHCEHGKCLDGLEGNGQCICFKGWKGVKCSVVVVDDACGGVCDVNANCISGDSGTPPTCSCTAGYKGNGTSCEEINPCAEDNGGCSVNANCTKTAPGERTCTCTTNYIGDGVICVEMDACLVNNGGCDENAICMKTGPNRVACACRPGFISQGHRCLAVNPCRKDNGGCSVNAVCRYLGAGERNCTCYIGFKGDGLQCAGTVSREISRNPEAMWFRNNLGAFRFRDWVGRGPFTVFVPHADYVTNFSNPQVDSWINSSHSSELLRYHIVSCEELHLSDLKSVKEVVTANGYKLRFSVRDGVVYINDNTKIITSDIECSNGILHYIDKVLIPYDITGKAEISTNLNITAAAEQYGFKMFGKLLQDAGLMHVVQHRAFYPFTMFWPTDDVFNNLTEDRKTWLYSEDHRDKLQGYLKAHIVRDERIAAIGLPTEKRLQTLFGSEITFSCNKDLIGDILINGNNARIVNRNMLFDSGIAHGIDQLLEPPSIGARCDDFRSIEIKGRCGSCLSPPLCPYGSTDMNRTSICRQPYRPYRMPNYYGMYSYGYGYRSYRDFLGCDRVCTKLTWDTKCCKNHFGRDCQVCSGGLEAPCGEHGDCDDGQGGTGVCKCHTGFTGKGCELCLANHFGPNCTACNCTIHGKCDEGLDGDGSCFCQEGWMGESCQTAIEVKSICSPACDLNAVCLPENQCECLEPYEGNGINCTAPDLCSEYNGGCHEEADCMQSGINITCSCQTGYSGDGHVCEPINRCVEEANGGCSDFAKCIFTGPNERRCQCLDGYVGNGVQCLEKVVPPVDRCLEDNGGCDPKAICRDLHFHTKTAGVFHLRSPEGKYKMNFTQAKQACEAEGANLATFSQLSDAQQLGMHLCVAGWMDGEKAGYPIRFPSAKCGDNHVGIVVYKDPVNSSWLYDAYCYRMNEVACECGAGYVGSGAFCNGDLASVVATTSNFSVFYTNLLKYAEDGEDGKTLLKALSDKSLNMTIFIPQNNGFGANKTLSWRDLQYHISSVNNIHYYENLKHNTAIPSRLGSKLIITIPSNSSGQTEDAQPQKLVNKKVILAWNIPAINGLIHVIDGPFRAPPVPVPAVLPITQSSGVAVTTVLVVIAIVCIVAGLAYYVLRHKNDAFRFQYFKNDDEDGASTKAGGNALVSIPNPLYSGYRAFAEPFGDSAATDTPNLID
InterPro domains: - IPR000538: Link domain (domain) [2196-2294]
- IPR016187: C-type lectin fold (homologous_superfamily) [2189-2307]
- IPR000742: EGF-like domain (domain) [100-2164]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [2198-2294]
- IPR056806: Stabilin-1/2, EGF-like domain (domain) [758-806]
- IPR002049: Laminin-type EGF domain (domain) [110-2019]
- IPR001881: EGF-like calcium-binding domain (domain) [222-1537]
- IPR000782: FAS1 domain (domain) [347-2455]
- IPR036378: FAS1 domain superfamily (homologous_superfamily) [358-2452]
- IPR024731: NELL2-like, EGF domain (domain) [818-2163]
Interaction partners: - Claudin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0051094 (positive regulation of developmental process), GO:0050793 (regulation of developmental process), GO:0022603 (regulation of anatomical structure morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)