Protein: SKP1-like protein 16 (AtSK16) (O81055)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity).
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MSSNKIVLTSSDDESFEVEEAVARKLKVIAHMIDDDCADKAIPLENVTGNILALVIEYCKKHVLDDVDDSDDSTEATSENVNEEAKNELRTWDAEFMKEFDMETVMKLILAVNYLNVQDLLGLTCQTVADHMKDMSPEEVRELFNIENDYTPEEEDAIRKENAWAFEDLK
InterPro domains: - IPR001232: S-phase kinase-associated protein 1-like (family) [3-117]
- IPR016073: SKP1 component, POZ domain (domain) [4-63]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [1-168]
- IPR036296: SKP1-like, dimerisation domain superfamily (homologous_superfamily) [89-165]
- IPR016897: S-phase kinase-associated protein 1 (family) [1-168]
- IPR016072: SKP1 component, dimerisation (domain) [118-165]
Interaction partners: - Cullin-1
- Cullin-like protein 3
- Cullin-2
- Putative cullin-like protein 2
- Putative cullin-like protein 1
- RING-box protein 1a
- RING-box protein 1b
- F-box protein 7
- Elongin-C
- Cullin-3A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009755 (hormone-mediated signaling pathway), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009725 (response to hormone), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0009867 (jasmonic acid mediated signaling pathway), GO:0071398 (cellular response to fatty acid), GO:0071395 (cellular response to jasmonic acid stimulus), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0140535 (intracellular protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0009524 (phragmoplast), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0005739 (mitochondrion), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0019005 (SCF ubiquitin ligase complex), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)