Protein: REL proto-oncogene, NF-kB subunit (F1M5R1)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MASSGYNPYVEIIEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQIMNYYGKGKVRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGPERRPLFFQNLGIRCVKKKEVKEAIILRISAGINPFNVPEQQLLDIEDCDLNVVRLCFQVFLPDEHGNFTTALPPIVSNPIYDNRAPNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQVAIVFRTPPYCRAIVEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDAYGNKSKKQKTTLIFQKLLQDCESNLFSHGTVLPETPRSSGVPGQAEPYYSSSGSISNALPHHPSAMPSMVHQPASWSPVTHPTSHPGSTNTLSSFPAGQLSSNSQGVLPFLDGAGMNDLSASNACLFSTDNLARMETPSMSPTDLYSISDVNMLTNRPVSVMTSSTDGMGDTDHPRLVSVNLENPSCNSRLDPRDPRQLHQMSTASMSAAGTSSSSVFVSQSDTFNRPHFSCIDNGLTNEPGLANDAHHPNFAQSSQYSGIDALQSEQLGDSFEYSFFKI
InterPro domains: - IPR002909: IPT domain (domain) [185-280]
- IPR042845: Proto-oncogene c-Rel, RHD, N-terminal subdomain (domain) [8-179]
- IPR000451: NF-kappa-B/Dorsal (family) [6-453]
- IPR037059: Rel homology domain (RHD), DNA-binding domain superfamily (homologous_superfamily) [7-179]
- IPR033926: NFkappaB IPT domain (domain) [186-281]
- IPR032397: Rel homology dimerisation domain (domain) [187-282]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [7-188]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [183-295]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [183-307]
- IPR011539: Rel homology domain, DNA-binding domain (domain) [5-182]
- IPR030492: Rel homology domain, conserved site (conserved_site) [23-29]
Interaction partners: - Nuclear factor NF-kappa-B p105 subunit
- Transcription factor RelB
- Transcription factor p65
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a.
- NF-kappa-B inhibitor alpha
- NF-kappa-B inhibitor beta
- NF-kappa-B inhibitor epsilon
- Serine/threonine-protein kinase TBK1
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- TPX2, microtubule nucleation factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0035556 (intracellular signal transduction), GO:0007249 (I-kappaB kinase/NF-kappaB signaling), GO:1901214 (regulation of neuron death), GO:1901215 (negative regulation of neuron death)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005667 (transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)