Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase 6 (Protein mannosyltransferase 6) (EC 2.4.1.109) (Q5A688)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation and virulence.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33775}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MATGYSTGVSPFDLDENNHNDSIHHRHQNHHSQSHDSSGERDDTEIEDIIQKTSKLNINTSTSTKIKNFFFQSSNRHDSSNSPPLREVFIKTINPLILTAISSFVRLYRIDVANSVVWDEAHFGKFGSQYLKRQFYFDVHPPLGKLLIGLSGYLADYDGNFDFESSNVYPDNVNYVFMRIFNCFFGILVTPLAYKTAVILGYNQFTCWLIAFMVIFEQLSLTLSKFILLDSMLLFFTVLTMYCLVKVHTLAIARVGSNSKTPLTKLEIKWYILTGISIGCVCSVKWVGLFVTALVGFYTIVDLWIKFYQTFAIDKKSPKKMSVVNYLIHWVVRIFTLIIIPMTIYVATFKVHFMVLNHTGPDDGTLSTLLQGSLIGNDLQSGPRSVAFGSLVTIRSQGLSPNLIHSHPHNYPQGSQEQQVTTYGFKDDNNEFLFEFGVDAGLRNQHATLENENSTRNGGNDDDYYHVIIHDGDTVRINHKNTGSYLRANAVGAPITSSSYEVSCFGDVESNDWADEWVIEIQSQDQSPDPMFQDEDPSEIHSVSTSFRLKHKQLGCYLATTGKSYPAWGYQQGEVVCKYSVFSRDKNTWWNIEKHVNNKLPLPATEYVPPKPKFWKEFILLNYAMMASNNALIPDPDRFDKLSSEWWEWPILNTGLRMNSWGDADIKYFLLGNPLITWISTIALIVCPLYLLVVGIKYQRQWILLSATDTSNANPANSQSLSLLAARALLPLAGWVLHYVPFILMGRVKYLHHYVPALYFAIFVAGFIVDAILNLDFSYHNNKFQYIFKVVIYSTLYLVICISFWYFKDLSFGMEGSSVDYRHLRLLGSWMI
InterPro domains: - IPR016093: MIR motif (domain) [383-595]
- IPR003342: ArnT-like, N-terminal domain (domain) [97-357]
- IPR027005: O-mannosyl-transferase-like (family) [72-831]
- IPR036300: Mir domain superfamily (homologous_superfamily) [381-591]
- IPR032421: Protein O-mannosyl-transferase, C-terminal four TM domain (domain) [614-830]
Interaction partners: - Dolichyl-phosphate-mannose--protein mannosyltransferase 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071554 (cell wall organization or biogenesis), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0097502 (mannosylation), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0071555 (cell wall organization), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0009100 (glycoprotein metabolic process), GO:0035268 (protein mannosylation), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0045229 (external encapsulating structure organization), GO:0009101 (glycoprotein biosynthetic process), GO:0006493 (protein O-linked glycosylation), GO:0035269 (protein O-linked mannosylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)