wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Erythrocyte vesicle protein 1 (Q9U0I6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MYKKCFILYPIFFPSLYIYIIKNDHLNSEQSSFSRIIAEYCDTKKNEFFLGESILGATSSRSTSLNIEQNKNTNIIKDKNEQSYDEHIVMNPNTNRALSINTVFNYNKENKEKKIFSFSEFPKEFNILDVVWPYMKQPKELFKKSSVITFLMDHYFRHELYILESRIAMKPRRRTYEAPCFEHDDFELERDFFFLEDCDEDHQFFNKYKSYFFSLNVLDHCKSLRTKKQKCNNMKDDEVSNINDDEVSNINDDEVSNINDDEVSNIKDDVVRNINDDVVRNINDDEVHHTNDDKVNHTNDDKVNHTNDDKVNHTNDDKVNHTNDDKVNHTNDDNVNHTNDDKVNHTNDDKVNHTNDDKVNHTNDDKVNHTNNYYNDKKNNAGDIKTNNSIREEKKLEHPDRNIEKKIDLITYNKKRIEEYYDSIISYFFGLIILYHNKKETNLNYYTKFLTLDKYKNMYNCLNNDISKIYEKAILFSHEEFCIIQKKDLKPHGLRGNIKYYYFFNRIVSTSLYLLHEILQKLDGKMYTFQKLPLKIQNHLINLPDIRIKEIKKRMRQQKKKNQNSLLESSSYKDLYYVSSEYYDYVSKCLIWSNYYFFNYMSTTIVYSVKKRSYEYIQKEKSKINLFLEYAHNDIIEYIKDITYYFKLIVNKIESKRLFSEPVMLCFQLFSDHYLYLLKNILSILLIHIEKPVTRKSNRDLKKIFNCIKDQENITKNILDEFHSKNKIRYNPTEFLIYKFFSSIQYKQNIAHKYIIQSNINIISLMLKIFNYFHILVISLIFYLNLHSMYTLFIDLDIDDTLKFQHDQEFLNYFKRYQDFNNQLFDSFRSDDR
InterPro domains: - IPR053118: Host-Pathogen Interaction Adhesin/Serine-rich (family) [26-565]
Interaction partners: - Rhoptry protein RHOP148
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process), GO:0000723 (telomere maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm)
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Q9N3D9)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}. Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
Sequence: MATGNRNPENFTSLSPIVKAPITDTLSVPLSQQGRICGFFESQFYRCMEAYGAKMGRKYCDLEHRDFQECVTGDKQKKRADAIREQRCKLFLDGKIAKPYVDNHPEPGQFKTDHFQWNRIN
InterPro domains: - IPR019342: NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5 (family) [32-99]
Interaction partners: - NADH dehydrogenase 1 alpha subcomplex subunit 6
- NADH dehydrogenase 1 alpha subcomplex subunit 7
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- Probable NADH dehydrogenase iron-sulfur protein 6, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH dehydrogenase 1 beta subcomplex subunit 4
- NADH dehydrogenase iron-sulfur protein 4
- NADH dehydrogenase 1 beta subcomplex subunit 8
- NADH dehydrogenase iron-sulfur protein 3
- NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: PPPDE domain-containing protein (Q385N7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MPLCCCKDENNSTVDKIPDTIETGEVVLKRCAPPVLTRDDFVEVQVHVNVYSLLKRNGCFKKIGMGVFHCGIVVYGIEWGYGECMDPNTASGLFCVCPGHAAGSLYRTICLGVTTRSPEQVDTILHRLENEWRSADYHILAHNCNHFAQRFCDMLSTVQKLQLPAWCNRAARVCNKVVPRRLASYIHRMMDEPPPKATPAAPSRVRELPTSVIPPLWYNYYCVSKNPRYVTLQNTESERLFFMRENGDTPQDKKRFGVQQPRVPKTRAAVPKISIVRRGGVGVAEWSTLREGSAPPPAPKRRGTNVTDSLAMKDKSNGVCNGESSSASDSEPSGVLDKHSTSVRVVDSLRYIRGGSVSGANTDRRAPSGSSKETPGDRIDPEESDDEDDALYSSEDGATIRIERKLETGSSRTDTSSTPTDEHRAFEGGVVLPNGVLASDFSSAEASLNDARECREGFNGAEQLMRSNDTVSHVIHVHHGKILRSVDQSQTRDSAGETSFVDSSRGVTAMKTIAPSLTVTSTSQAYGSGDRTRNEISRSSIGMHGSSCGLGDLSLPSTRRCGEGSDLPDGGVVGFSSAPASRAMCSDSVTVELQHEENGDLYSDPGGGRIAGVDSSLFHTSVSSTKGGSLSNNLPNPLLALNKRLGPHMRTYSSPF
InterPro domains: - IPR008580: PPPDE peptidase domain (domain) [43-325]
- IPR042266: PPPDE peptidase domain superfamily (homologous_superfamily) [41-201]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070646 (protein modification by small protein removal), GO:0070647 (protein modification by small protein conjugation or removal), GO:0016579 (protein deubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Large ribosomal subunit protein eL43y (60S ribosomal protein L37a-2) (Q8RXU5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MAKRTKKVGIVGKYGTRYGASIRKQIKKMEVSQHSKYFCEFCGKYGVKRKAVGIWGCKDCGKVKAGGAYTMNTASAVTVRSTIRRLREQIEG
InterPro domains: - IPR002674: Large ribosomal subunit protein eL43 (family) [1-91]
- IPR011332: Zinc-binding ribosomal protein (homologous_superfamily) [10-82]
- IPR050522: Eukaryotic ribosomal protein eL43 (family) [1-91]
- IPR011331: Large ribosomal subunit protein eL37/eL43 (homologous_superfamily) [1-92]
Interaction partners: - Large ribosomal subunit protein eL42z/eL42y
- Small ribosomal subunit protein eS24z
- Large ribosomal subunit protein eL24y
- At1g43860
- Large ribosomal subunit protein eL38z/eL38y
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein uL24z
- Large ribosomal subunit protein uL11x
- Large ribosomal subunit protein eL8y
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Probable sphingolipid long chain base-responsive protein pil1 (Protein kinase inhibitor pil1) (O74960)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity).
Sequence: MMNRAYSLRNSRAPTASQLLNPPPPSSSTRSGRLFAPLSHTMRINHAATFTPDLAKRLAVLVKMEKNVMRSMEVTIRGRRDCARQLSYWGEDCDDDISDVTDKLGVLFYEMAELENYLIDRYDQYRMTLKSIRNIESSVQPSREKKQKLLDQIYALKHKDPESPRLVTMEQELVREEAACLVAEAQLSNTTREKFKQAMTFNLDALHEHAEKLNLIATYGRHLLNLIDDTPVTPGEARPAYDGYETSRQIVMDAEHALSSWVPSQPAVNFVKPQIEDDAQSDARSWNEYEAQGEPVPVEQVTHLQDDVQSDTSEIIENEPGMHPHVHAERMSRIASESSDAVPQQTAVQVA
InterPro domains: - IPR028245: Eisosome component PIL1/LSP1 (family) [1-305]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [51-266]
Interaction partners: - Eisosome protein sle1
- Protein hob1
- Non-classical export protein 2 homolog
- Inositol-1,4,5-trisphosphate 5-phosphatase 1
- Cytoskeletal signaling protein slm1
- Ribosomal RNA-processing protein 14-C
- SUR7 family protein pun1
- Meiotically up-regulated gene 33 protein
- Vesicle-associated membrane protein-associated protein scs2
- Uncharacterized transporter C18H10.16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Large ribosomal subunit protein eL34 (60S ribosomal protein L34) (Q9D1R9)
Organism: Mus musculus (Mouse)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49207}. Cytoplasm {ECO:0000269|PubMed:36517592}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q29223}. Note=Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49207, ECO:0000250|UniProtKB:Q29223}.
Sequence: MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGVRAVRPKVLMRLSKTQKHVSRAYGGSMCAKCVRDRIKRAFLIEEQKIVVKVLKAQAQSQKAK
InterPro domains: - IPR008195: Large ribosomal subunit protein eL34 (family) [1-117]
- IPR038562: Large ribosomal subunit protein eL34, C-terminal domain superfamily (homologous_superfamily) [39-117]
- IPR018065: Large ribosomal subunit protein eL34, conserved site (conserved_site) [15-28]
Interaction partners: - Large ribosomal subunit protein eL8
- Large ribosomal subunit protein uL3
- Large ribosomal subunit protein uL10
- Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL27
- Large ribosomal subunit protein uL15
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS8
- Ubiquitin-like protein FUBI
- Large ribosomal subunit protein uL29
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0045202 (synapse)
Protein: Very-long-chain aldehyde decarbonylase GL1-1 (EC 4.1.99.5) (Protein GLOSSY 1-1) (Q69PA8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Aldehyde decarbonylase involved in the conversion of aldehydes to alkanes. Core component of a very-long-chain alkane synthesis complex.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:F4HVY0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F4HVY0}.
Sequence: MGAAFLSSWPWDNLGAYKYVLYAPLVGKAVAGRAWERASPDHWLLLLLVLFGVRALTYQLWSSFSNMLFATRRRRIVRDGVDFGQIDREWDWDNFLILQVHMAAAAFYAFPSLRHLPLWDARGLAVAALLHVAATEPLFYAAHRAFHRGHLFSCYHLQHHSAKVPQPFTAGFATPLEQLVLGALMAVPLAAACAAGHGSVALAFAYVLGFDNLRAMGHCNVEVFPGGLFQSLPVLKYLIYTPTYHTIHHTKEDANFCLFMPLFDLIGGTLDAQSWEMQKKTSAGVDEVPEFVFLAHVVDVMQSLHVPFVLRTFASTPFSVQPFLLPMWPFAFLVMLMMWAWSKTFVISCYRLRGRLHQMWAVPRYGFHYFLPFAKDGINNQIELAILRADKMGAKVVSLAALNKNEALNGGGTLFVNKHPGLRVRVVHGNTLTAAVILNEIPQGTTEVFMTGATSKLGRAIALYLCRKKVRVMMMTLSTERFQKIQREATPEHQQYLVQVTKYRSAQHCKTWIVGKWLSPREQRWAPPGTHFHQFVVPPIIGFRRDCTYGKLAAMRLPKDVQGLGACEYSLERGVVHACHAGGVVHFLEGYTHHEVGAIDVDRIDVVWEAALRHGLRPV
InterPro domains: - IPR006694: Fatty acid hydroxylase (domain) [129-269]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [448-516]
- IPR050307: Sterol Desaturase and Related Enzymes (family) [30-278]
- IPR021940: Very-long-chain aldehyde decarbonylase CER1-like, C-terminal (domain) [448-618]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016716 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006970 (response to osmotic stress), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901700 (response to oxygen-containing compound), GO:0033993 (response to lipid), GO:0097305 (response to alcohol), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030312 (external encapsulating structure), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Homeobox protein Hox-C10 (Homeobox protein Hox-3I) (Q9NYD6)
Organism: Homo sapiens (Human)
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location: Nucleus.
Sequence: MTCPRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASLNPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADSSPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTSNFNFT
InterPro domains: - IPR001356: Homeodomain (domain) [266-330]
- IPR020479: Homeodomain, metazoa (domain) [290-324]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [258-328]
- IPR017970: Homeobox, conserved site (conserved_site) [301-324]
- IPR046333: Homeobox protein Hox-A10/abdominal-B-like (family) [1-342]
Interaction partners: - T-box transcription factor TBX4
- Homeobox protein Hox-C9
- Homeobox protein Hox-C11
- T-box transcription factor TBX5
- Homeobox protein Hox-C6
- Homeobox protein Hox-C13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Probable assembly chaperone of rpl4 (Q1MTN8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Acts as a chaperone for the L4 ribosomal subunit encoded by rpl4A and rpl4B, required for hierarchical ribosome assembly. Shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q03771}. Nucleus {ECO:0000250|UniProtKB:Q03771}. Nucleus, nucleolus {ECO:0000269|PubMed:16823372}. Note=Distributed throughout the cell but is enriched in the nucleus. {ECO:0000250|UniProtKB:Q03771}.
Sequence: MSVTDAELLEIREKLVKDETSEALILAKKAADKSPKEDGRAFELLGEVYAELADVKKARSAFKEAVSRSKNLTNDQGYEKYLWLAQINDNGSKALKLYQKGVTILERLLIDKGEDADLKKKIQGAYCSIAELFMTDLCMQPDAEENCELYTKLALQIDATNAEALQTLASMRISQQKIEEAKDALSKCLQSISRAATEDSVDLPTYAVRTSIVRLLIEVEMHEEAHQLLVYLQKEDDQILDIWYLLGWNCYVEAQNLQEQGNGSEEEIKELLMNAKFYFISALGVYQKIGWDDEGIKSHIQELLEILNGLGVPNMDEENEEAEWETSENEEEMDED
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [5-328]
- IPR019734: Tetratricopeptide repeat (repeat) [39-72]
Interaction partners: - Ribosome assembly protein rrb1
- Ankyrin repeat-containing protein P16F5.05c
- Pre-rRNA-processing protein tsr2
- Phosphoglycerate kinase
- Triosephosphate isomerase
- mRNA 3'-end-processing protein rna14
- Large ribosomal subunit protein uL4B
- Large ribosomal subunit protein uL4A
- tRNA
- Glucose-6-phosphate isomerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0030968 (endoplasmic reticulum unfolded protein response), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0035966 (response to topologically incorrect protein), GO:0034976 (response to endoplasmic reticulum stress), GO:0035967 (cellular response to topologically incorrect protein), GO:0006986 (response to unfolded protein), GO:0071310 (cellular response to organic substance), GO:0034620 (cellular response to unfolded protein)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)