Protein: Ras-related protein R-Ras (EC 3.6.5.-) (p23) (P10833)
Organism: Mus musculus (Mouse)
Function: Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
Subcellular location: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Sequence: MSSGAASGTGRGRPRGGGPGPRDPPPGETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDPTIEDSYTKICTVDGIPARLDILDTAGQEEFGAMREQYMRAGNGFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPIVLVGNKADLENQRQVLRSEASSFSASHHMTYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKDGGCPCVLL
InterPro domains: - IPR001806: Small GTPase (family) [23-218]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [25-200]
- IPR005225: Small GTP-binding domain (domain) [29-185]
- IPR020849: Small GTPase, Ras-type (family) [30-196]
Interaction partners: - Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- Ral guanine nucleotide dissociation stimulator
- Plexin-B1
- Plexin-B2
- Neurofibromin
- RalA-binding protein 1
- Son of sevenless homolog 1
- Leucine-rich repeat protein SHOC-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0048869 (cellular developmental process), GO:0009653 (anatomical structure morphogenesis), GO:0051240 (positive regulation of multicellular organismal process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0010632 (regulation of epithelial cell migration), GO:0045597 (positive regulation of cell differentiation), GO:0010171 (body morphogenesis), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:2000145 (regulation of cell motility), GO:0035556 (intracellular signal transduction), GO:0060324 (face development), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0060325 (face morphogenesis), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0045595 (regulation of cell differentiation), GO:0045785 (positive regulation of cell adhesion), GO:0060323 (head morphogenesis), GO:2000147 (positive regulation of cell motility), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0010594 (regulation of endothelial cell migration), GO:0010810 (regulation of cell-substrate adhesion), GO:1901342 (regulation of vasculature development), GO:0010634 (positive regulation of epithelial cell migration), GO:0045766 (positive regulation of angiogenesis), GO:0030335 (positive regulation of cell migration), GO:0045765 (regulation of angiogenesis), GO:0030334 (regulation of cell migration), GO:0007264 (small GTPase mediated signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0007265 (Ras protein signal transduction), GO:0051896 (regulation of protein kinase B signaling), GO:0001954 (positive regulation of cell-matrix adhesion), GO:0001952 (regulation of cell-matrix adhesion), GO:0010595 (positive regulation of endothelial cell migration), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)