Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (X2JC83)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MPAGRETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADNDPEDSQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQKSGYKAASYNNNSTDGSKISPSQSTRSSYKPYAVNVQRSATLPANSSLK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [84-410]
- IPR046349: C1-like domain superfamily (homologous_superfamily) [1239-1299]
- IPR001849: Pleckstrin homology domain (domain) [1124-1334]
- IPR050839: Rho-associated Serine/Threonine Kinase (family) [19-647]
- IPR000961: AGC-kinase, C-terminal (domain) [350-420]
- IPR057529: MRCK/ROCK kinase, PH domain (domain) [1118-1208]
- IPR015008: ROCK, Rho binding domain (domain) [962-1028]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [1244-1298]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [205-217]
- IPR017441: Protein kinase, ATP binding site (binding_site) [93-116]
- IPR000719: Protein kinase domain (domain) [87-349]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1126-1232]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0051020 (GTPase binding), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0022402 (cell cycle process), GO:0007389 (pattern specification process), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0021700 (developmental maturation), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0051651 (maintenance of location in cell), GO:0007300 (ovarian nurse cell to oocyte transport), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0051235 (maintenance of location), GO:0030029 (actin filament-based process), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0060142 (regulation of syncytium formation by plasma membrane fusion), GO:0000910 (cytokinesis), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0080134 (regulation of response to stress), GO:0007051 (spindle organization), GO:0007308 (oocyte construction), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0045184 (establishment of protein localization), GO:0044087 (regulation of cellular component biogenesis), GO:0071695 (anatomical structure maturation), GO:0000902 (cell morphogenesis), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0048469 (cell maturation), GO:0051231 (spindle elongation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0009994 (oocyte differentiation), GO:0051128 (regulation of cellular component organization), GO:0007276 (gamete generation), GO:0030048 (actin filament-based movement), GO:0007281 (germ cell development), GO:0007309 (oocyte axis specification), GO:0009798 (axis specification), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0032507 (maintenance of protein location in cell), GO:0051649 (establishment of localization in cell), GO:0051130 (positive regulation of cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0030036 (actin cytoskeleton organization), GO:1903036 (positive regulation of response to wounding), GO:0007059 (chromosome segregation), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0008335 (female germline ring canal stabilization), GO:0006810 (transport), GO:0007164 (establishment of tissue polarity), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0000278 (mitotic cell cycle), GO:1903035 (negative regulation of response to wounding), GO:0045185 (maintenance of protein location), GO:0051647 (nucleus localization), GO:0007369 (gastrulation), GO:0032956 (regulation of actin cytoskeleton organization), GO:0002009 (morphogenesis of an epithelium), GO:0007052 (mitotic spindle organization), GO:0016331 (morphogenesis of embryonic epithelium), GO:1901739 (regulation of myoblast fusion), GO:1902903 (regulation of supramolecular fiber organization), GO:0032233 (positive regulation of actin filament bundle assembly), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007292 (female gamete generation), GO:0032231 (regulation of actin filament bundle assembly), GO:0002064 (epithelial cell development), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0008544 (epidermis development), GO:0048599 (oocyte development), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0090303 (positive regulation of wound healing), GO:0007097 (nuclear migration), GO:0007264 (small GTPase mediated signal transduction), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0022604 (regulation of cell morphogenesis), GO:0098813 (nuclear chromosome segregation), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:1901888 (regulation of cell junction assembly), GO:0140014 (mitotic nuclear division), GO:0048477 (oogenesis), GO:0031532 (actin cytoskeleton reorganization), GO:0000022 (mitotic spindle elongation), GO:0030855 (epithelial cell differentiation), GO:0050770 (regulation of axonogenesis), GO:0070252 (actin-mediated cell contraction), GO:0033043 (regulation of organelle organization), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0010638 (positive regulation of organelle organization), GO:0031032 (actomyosin structure organization), GO:0051174 (regulation of phosphorus metabolic process), GO:0000281 (mitotic cytokinesis), GO:0001736 (establishment of planar polarity), GO:0009792 (embryo development ending in birth or egg hatching), GO:0051493 (regulation of cytoskeleton organization), GO:0003383 (apical constriction), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0110020 (regulation of actomyosin structure organization), GO:0051496 (positive regulation of stress fiber assembly), GO:0007391 (dorsal closure), GO:0061041 (regulation of wound healing), GO:0003381 (epithelial cell morphogenesis involved in gastrulation), GO:0008360 (regulation of cell shape), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0003382 (epithelial cell morphogenesis), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0019220 (regulation of phosphate metabolic process), GO:0000819 (sister chromatid segregation), GO:0001738 (morphogenesis of a polarized epithelium), GO:0110053 (regulation of actin filament organization), GO:0051492 (regulation of stress fiber assembly), GO:0051495 (positive regulation of cytoskeleton organization), GO:0000280 (nuclear division), GO:0003384 (apical constriction involved in gastrulation), GO:0010975 (regulation of neuron projection development), GO:0042325 (regulation of phosphorylation), GO:0007266 (Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0045179 (apical cortex), GO:0070161 (anchoring junction), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0005911 (cell-cell junction), GO:0099738 (cell cortex region), GO:0044291 (cell-cell contact zone)