Protein: A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor (S5RVW8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence: MVVLSLRLLIVGVVVSLTSAHLAGEIIDKEDLLKNRLKEYGLITPISTDAEGHFLSHFLSANHKQRVKRDVLEGSALAPDRLFFNITVFGKEFHLRLHPNQRLVAPGAMVEWHDDIEIAENATDNRTHFERILKRELLKTDCTFIGDITDVPGASVAINNCDGLAGMIRTDSDEYFIEPLEQGTQEHEERGRVHVVYRRSAVLQTPSDISLDYQPIEPELDAPRMLDNIAKQVNKTVRRRRHAGDEDYNIEILLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLEVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWAFVQQKEDPEHSEHHDHAIFLTRQGFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSMCSGQELKRYIHSYDCLLDDPFKHDWPQLPELPGINYSMDEQCRFDFGVGYKICTSFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCYKGHCMWKNANQVKQDGAWGAWSKYGSCSRSCGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLCNTGDCPKHFEDFRAQQCQLRNSHFEYQNAKHHWLPYEHPDANKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRVPKKAGYLKMFLIPPGARHVIIQEHEASPQILAIKNQATGHYVLNGKGEDARSRRFIEMGVEWDYLVEEDVETLHTDGPLNDAIVVLIIPKDNETRSTLMYKYIIHEDSVPLNNNNVIQEDTYEWALKSWSQCSRPCAGGFQYTKYGCRKKGDNKMVHRGYCDVNKKPKPIRRMCNLQDCTQPQWITEEWEHCTKTCGSLGYQIRTVRCVQFLHEGTNRSIHSKYCNGEKPEMRRACNRVACPAQWRTGAWSECSVSCGEGVSRRLVTCRIGDQCTGEKPESQKPCRPRPCHDEPCGGDKSIFCQMEVLARYCSIPGYNKLCCESCSRRSGTFAPLLHEAAETEEELRFGSASQLLETLSAAANGSLKVPQQHQRGSTSQGQFSKQAATPPPRKHNTENSKTQKRLKPSARNLPALSIHSSWSEDGVKDAPMQLESFQESQWPTTSSEVER
InterPro domains: - IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [245-453]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [543-1005]
- IPR010909: PLAC (domain) [1000-1043]
- IPR041645: ADAMTS, cysteine-rich domain 2 (domain) [464-533]
- IPR045371: ADAMTS/ADAMTS-like, cysteine-rich domain 3 (domain) [624-704]
- IPR010294: ADAMTS/ADAMTS-like, Spacer 1 (domain) [706-819]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [248-452]
- IPR002870: Peptidase M12B, propeptide (domain) [42-148]
- IPR013273: ADAMTS/ADAMTS-like (family) [552-704]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [542-1009]
- IPR050439: ADAMTS and ADAMTS-like (family) [272-1039]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0021954 (central nervous system neuron development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0021955 (central nervous system neuron axonogenesis), GO:0007409 (axonogenesis), GO:0021952 (central nervous system projection neuron axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)