Protein: Netrin receptor UNC5C (Protein unc-5 homolog 3) (cUNC-5H3) (Protein unc-5 homolog C) (Q7T2Z5)
Organism: Gallus gallus (Chicken)
Function: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O08747}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:O95185}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}. Cell projection, axon {ECO:0000250|UniProtKB:O08747}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08747}. Cell projection, growth cone {ECO:0000250|UniProtKB:O08747}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O08747}. Cell projection, filopodium {ECO:0000250|UniProtKB:O08747}.
Sequence: MGKGLEGTAARCGLGMGYLLHSVVLPALAVLGASRPGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHVVDERVDETSGLIVCEVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEEVIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSACNSRCGRGFQKRTRTCTNPAPLNGGAFCEGQNVQKIACTTLCPVDGKWTSWSKWSTCGTECTHWRRRECTAPAPKNGGKDCEGLVLQSKNCTDGLCMQAAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDELSDFSSKLSPQITQSLLENETLNVKNQSLARQTDPSCTAFGTFNSLGGHLVIPNSGVSLLIPAGAVPQGRVYEMYVTVHRKEGMRPPVEDSQTLLTPVVSCGPPGALLTRPVVLTMHHCAEPNMDDWQIQLKHQAGQGPWEDVVVVGEENFTTPCYIQLDPEACHILTETLSTYALVGQSITKAAAKRLKLAIFGPLSCSSLEYSIRVYCLDDTQDALKEVLQLERQMGGQLLEEPKTLHFKGSTHNLRLSIHDIAHSLWKSKLPAKYQEIPFYHIWSGCQRNLHCTFTLERFSLNTLELVCKLCVRQVEGEGQIFQLNCSVSEEPTGIDYPIMDSAGSITTIVGPNAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLKLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGNY
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [62-260]
- IPR042154: UNC5C, death domain (domain) [844-926]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [834-930]
- IPR037936: Netrin receptor UNC5A-D (family) [223-920]
- IPR013098: Immunoglobulin I-set (domain) [168-257]
- IPR033772: UPA domain (domain) [678-817]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [57-259]
- IPR007110: Immunoglobulin-like domain (domain) [175-256]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [260-368]
- IPR003598: Immunoglobulin subtype 2 (domain) [179-246]
- IPR003599: Immunoglobulin domain subtype (domain) [173-258]
- IPR000488: Death domain (domain) [838-929]
- IPR057755: Netrin receptor UNC5A-D-like, N-terminal domain (domain) [57-160]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [259-367]
- IPR000906: ZU5 domain (domain) [528-664]
Interaction partners: - Adhesion G protein-coupled receptor L2
- Adhesion G protein-coupled receptor L3
- Netrin-3
- Netrin-1
- Neogenin
- Fibronectin leucine rich transmembrane protein 2
- Netrin 4.
- Netrin-4
- Cell adhesion molecule DSCAM
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0035234 (ectopic germ cell programmed cell death), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0000902 (cell morphogenesis), GO:0010941 (regulation of cell death), GO:0060322 (head development), GO:0070887 (cellular response to chemical stimulus), GO:0010623 (programmed cell death involved in cell development), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0030030 (cell projection organization), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0030334 (regulation of cell migration), GO:0048666 (neuron development), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0006915 (apoptotic process), GO:0050919 (negative chemotaxis), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007411 (axon guidance), GO:2001222 (regulation of neuron migration), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0033564 (anterior/posterior axon guidance), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0030427 (site of polarized growth), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0030027 (lamellipodium), GO:0030426 (growth cone), GO:0005886 (plasma membrane), GO:0098858 (actin-based cell projection), GO:0043005 (neuron projection), GO:0030425 (dendrite), GO:0030175 (filopodium), GO:0030424 (axon)