Protein: Glycine cleavage system P protein (EC 1.4.4.2) (A0A0G2JUZ5)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000256|RuleBase:RU364056}.
Sequence: MQLCARAWGLRLGPGAGGGHRLARGTGLSWAPRSRDSSSGGGGGGGDRGAAGASRLLERLLPRHDDFARRHIGPGDKDRREMLQALGLASIDELIEKTVPASIRLKRPLKLEDPVCENEILETLHAIASKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWVTQYTPYQPEVSQGRLESLLNYQTMVSDITGLDMANASLLDEATAAAEAMQLCHRHNKRKRFFIDPRCHPQTIAVVQTRAKYRGVIVELKLPHEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQTGSLTCCATDLLALCILRPPGEFGVDIALGNSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLQHIAKRVHNATLILSEGLKRAGHQLQHDLFFDTLKVQCGCSLKEVLGRAAQRQINFRLFDDGTLGISLDETVTEKDLDDLLWIFGCESSTELVAEGMGEEWRGLLGSSFKRTSPFLTHQVFNSYHSETNLVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELTPITWREFANIHPFVPLDQAQGYQQLFQELEKDLCELTGYDRVSFQPNSGAQGEYAGLATIRAYLDQKGERHRTVCLIPKSAHGTNPASAYMAGMKIQPVEVDRYGNIDVAHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCALIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLVPFLPSHPIVCLKPNEDTWPVGTVSAAPWGSSSILPISWAYIKTPLSSMMGGKGLKEATEIAILNANYMAKRLERYYRVLFRGARGYVAHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMIEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSRWDRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS
InterPro domains: - IPR001597: Aromatic amino acid beta-eliminating lyase/threonine aldolase (domain) [590-733]
- IPR003437: Glycine dehydrogenase (decarboxylating) (family) [61-1017]
- IPR049316: Glycine dehydrogenase, C-terminal domain (domain) [838-959]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [148-800]
- IPR020581: Glycine cleavage system P protein (family) [53-1017]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [70-1013]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [137-964]
- IPR049315: Glycine cleavage system P-protein, N-terminal domain (domain) [69-492]
Interaction partners: - Glycine cleavage system H protein, mitochondrial
- Aminomethyltransferase
- Serine hydroxymethyltransferase
- Trifunctional purine biosynthetic protein adenosine-3
- Serine hydroxymethyltransferase
- Glycine cleavage system H protein
- Glycine cleavage system H protein
- Dimethylglycine dehydrogenase, mitochondrial
- Sarcosine dehydrogenase, mitochondrial
- Methylenetetrahydrofolate reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0019842 (vitamin binding), GO:0016638 (oxidoreductase activity, acting on the CH-NH2 group of donors), GO:0043177 (organic acid binding), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0019899 (enzyme binding), GO:0070279 (vitamin B6 binding), GO:0016594 (glycine binding), GO:0031406 (carboxylic acid binding), GO:0030170 (pyridoxal phosphate binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016043 (cellular component organization), GO:0006520 (amino acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0009063 (amino acid catabolic process), GO:0043933 (protein-containing complex organization), GO:1901605 (alpha-amino acid metabolic process), GO:0022607 (cellular component assembly), GO:0019752 (carboxylic acid metabolic process), GO:0065003 (protein-containing complex assembly), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009069 (serine family amino acid metabolic process), GO:0009071 (serine family amino acid catabolic process), GO:0006544 (glycine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)