Protein: Dishevelled segment polarity protein 3a (Segment polarity protein dishevelled homolog DVL-3a) (B8JMI2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MGETKVIYHLDDQETPYLVKLPIPAERVTLLDLKNALKKPNYKFFFKSMDDDFGVVKEEITDDNAKLPCYNGRVICWLVSSDGSHSDGCSVAESQSERPPSHERSQGIGDSRPPSFHPKAAGSRHGVDDETETDSVVSHRRDRDRDRSRRKHSHEHSGGKQNGYSRGGRGMDLGGYDICDSRSSLMSSELESSSCFDSDDGSTSRFSSVTEQSGSSKLMTKKPRRRRRKTRAQQMERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMCNDDAVRVLREIVHKPGPVSLTVAKCWDPNPNSCFALPRSEPIRPIDPAAWVSHTAAMTGVYPPYGMSPSMSTVTSTSSSISSSIPETERFDDYHLSVHSDMATVAKAMACPDSGLEVRDRMWLKITIANAFIGSDVVDWLFHHVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLSGNMAHLSLQDHDGSSGASDQDTLAPLLHPAEAPWPAAFPYQYPAAHSHLEEAGGGSAGSQQSEGSSGSNCSWSRTEGKTAAGDFRLGGGSEMGDAHEFDFRRDRAPSERSGVPPSEGSVRSSRSHSYSLKQGSARGGPGSPSGRHLAHIPPELTGSRRSCNTANGEFFVDIM
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [234-348]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [412-535]
- IPR003351: Dishevelled protein domain (domain) [87-251]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [2-80]
- IPR015506: Dishevelled-related protein (family) [2-670]
- IPR038207: DIX domain superfamily (homologous_superfamily) [1-81]
- IPR000591: DEP domain (domain) [428-502]
- IPR001158: DIX domain (domain) [1-82]
- IPR008339: Dishevelled family (family) [330-496]
- IPR001478: PDZ domain (domain) [255-343]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [398-502]
- IPR024580: Dishevelled C-terminal (domain) [506-669]
Interaction partners: - Axin-1
- Vang-like protein 2
- Vang-like protein
- Axin-2
- Dishevelled-associated activator of morphogenesis 1a.
- Protein naked cuticle homolog 1
- Protein naked cuticle homolog 2-like
- Glycogen synthase kinase-3 beta
- Disheveled-associated activator of morphogenesis 1b
- Glycogen synthase kinase-3 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005109 (frizzled binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0198738 (cell-cell signaling by wnt), GO:0048731 (system development), GO:0048513 (animal organ development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0009799 (specification of symmetry), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0042246 (tissue regeneration), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0048562 (embryonic organ morphogenesis), GO:0016055 (Wnt signaling pathway), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0022607 (cellular component assembly), GO:0009855 (determination of bilateral symmetry), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0009953 (dorsal/ventral pattern formation), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0007507 (heart development), GO:0070925 (organelle assembly), GO:0061371 (determination of heart left/right asymmetry), GO:0035567 (non-canonical Wnt signaling pathway), GO:0007368 (determination of left/right symmetry), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0003146 (heart jogging), GO:0001947 (heart looping), GO:0060026 (convergent extension), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0015630 (microtubule cytoskeleton)