Protein: Phosphoinositide phospholipase C (EC 3.1.4.11) (F1Q5G9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Membrane {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MTERQMASTERSLRIQADDDLKSMIVGTVMRKIKSRTWKKQRYFRLQEDCMTIWYQSKKAGNAHSTFSVGDVEAVREGHQSEVLLSIADEFPPDRCFTLVFRGRRGNLDLVAESTKEAQSWIKGIRKLIDNLENMGQREKLDQWICDWFKKADKNRDGRMNFKEVRDLLKMMNVDMNEHHALRLFTMADRSQSGTLEDDEFVLFYKMLTQREDILRVFQEYSADGQKLTLKDLKDFLQEEQLHEDGVQQYALNLIERFEPSDTAKMLQAMTFDGFLMYLSSSEGSIFNPAMLELYQDMSQPLCHYFISSSHNTYLLEDQIRGLSSVEGYIRALKRGCRCVEVDCWDGPNGEPIVYHGHTFTSKIFFKDVVTVLGNYSFKASEYPVILSIENHCSVEQQKIMAQHLTQILGDKLLKSTLDGKIPLGLPSPEDLKGKILLKGKKIGGLEDGMNGVVDDPLMGEVSDEEEATEIEDENHRNNSIRHRSKKSKQRLSKELSDCVVYCKSVHFSSFKHSRNHSKFYEISSFTESKARKHIREAGAEFVLHNARQLSRVYPSGLRTDSSNFNPQDLWNAGCQIVALNFQTAGVEMDLNDGLFNQNGRCGYVLKPAFMRNFEEMFDPENPQNREDYKPLSLSIQVISGQQLPKVNIKEGSIIDPFVRVEIHGVPLDQAKQETRYIDNNGFNPVWYDTLQFTIHAPELALVRFVVEDYDKTSKNDFVGQFTLPFTCIQPGYRHIHLLSKDGTSIPPSSLFVHIRITNLT
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [627-761]
- IPR001192: Phosphoinositide phospholipase C family (family) [21-758]
- IPR001849: Pleckstrin homology domain (domain) [22-132]
- IPR001711: Phospholipase C, phosphatidylinositol-specific, Y domain (domain) [496-612]
- IPR000008: C2 domain (domain) [619-740]
- IPR015359: Phosphoinositide-specific phospholipase C, EF-hand-like domain (domain) [204-289]
- IPR011992: EF-hand domain pair (homologous_superfamily) [140-295]
- IPR002048: EF-hand domain (domain) [140-240]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [153-201]
- IPR000909: Phosphatidylinositol-specific phospholipase C, X domain (domain) [296-442]
- IPR017946: PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily (homologous_superfamily) [292-623]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [13-140]
Interaction partners: - Family with sequence similarity 207 member A
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase.
- Phosphatase and tensin homolog A
- 1-phosphatidylinositol 3-phosphate 5-kinase
- Myotubularin 1.
- Si:ch211-160o17.2.
- Major facilitator superfamily domain-containing protein 6-A
- Formimidoyltransferase cyclodeaminase.
- CCR4-NOT transcription complex subunit 9
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0097367 (carbohydrate derivative binding), GO:0001530 (lipopolysaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009790 (embryo development), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0035239 (tube morphogenesis), GO:0061053 (somite development), GO:0048514 (blood vessel morphogenesis), GO:0060429 (epithelium development), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)