Protein: Recoverin (Cancer-associated retinopathy protein) (Protein CAR) (P35243)
Organism: Homo sapiens (Human)
Function: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity).
Subcellular location: Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}.
Sequence: MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKMKNA
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [3-189]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [110-122]
- IPR002048: EF-hand domain (domain) [41-182]
- IPR028846: Recoverin family (family) [10-183]
Interaction partners: - Rhodopsin kinase GRK1
- Rhodopsin kinase GRK7
- Rhodopsin
- S-arrestin
- Cone-rod homeobox protein
- Retinal guanylyl cyclase 1
- Amphiphysin
- Homeobox protein OTX2
- Voltage-gated potassium channel KCNC1
- Glutamate decarboxylase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0032879 (regulation of localization), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0009581 (detection of external stimulus), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0051049 (regulation of transport), GO:0009314 (response to radiation), GO:0007602 (phototransduction), GO:0009416 (response to light stimulus), GO:0043269 (regulation of monoatomic ion transport), GO:0007600 (sensory perception), GO:0009583 (detection of light stimulus), GO:0050953 (sensory perception of light stimulus), GO:0010959 (regulation of metal ion transport), GO:0051924 (regulation of calcium ion transport), GO:0007601 (visual perception)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)