Protein: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Cam-PDE 1B) (EC 3.1.4.17) (Q64395)
Organism: Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Function: Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q01064}.
Sequence: MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLEYTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNLDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKSKSQPSFQWRQPSLDVDVGDPNPDVISFRSTWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
InterPro domains: - IPR003607: HD/PDEase domain (domain) [219-392]
- IPR023088: 3'5'-cyclic nucleotide phosphodiesterase (family) [217-398]
- IPR013706: PDE1, N-terminal domain (domain) [76-136]
- IPR023174: 3'5'-cyclic nucleotide phosphodiesterase, conserved site (conserved_site) [262-273]
- IPR036971: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily (homologous_superfamily) [142-505]
- IPR002073: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain (domain) [145-502]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004112 (cyclic-nucleotide phosphodiesterase activity), GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity), GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity), GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0071417 (cellular response to organonitrogen compound), GO:0046683 (response to organophosphorus), GO:1901699 (cellular response to nitrogen compound), GO:0051591 (response to cAMP), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:0014074 (response to purine-containing compound), GO:0071320 (cellular response to cAMP), GO:0071407 (cellular response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)