Protein: Azole resistance protein 1 (P50080)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11113970}; Multi-pass membrane protein {ECO:0000269|PubMed:11113970}.
Sequence: MKGEPKTYSMSDLSYYGEKAQQQNEKQQKQYVVRRNSTQSTSKQNVSVVLEDNASESNELPKGFILYASLIALALSLFLAALDIMIVSTIIEEVAKQFGSYSEIGWLFTGYSLPNALLALIWGRIATPIGFKETMLFAIVIFEIGSLISALANSMSMLIGGRVIAGVGGCGIQSLSFVIGSTLVEESQRGILIAVLSCSFAIASVVGPFLGGVFTSSVTWRWCFYVNLPIGGLAFFLFLFFYNPGLSTFQETMDNIRKFPSQFIEIVRNVAYHLLKIKGFSKLNGWRKPFMELIFMYDIIEFVFCSAGFTCILLAFTFGGNRYAWNSASIIILFIIGIVLVVLAGIYDFLVFPKFNIVKATPHYQPLMSWTNIKKPGIFTVNIALFLTCAGYISQFTYIVQYFQLIYNDSAWRAAVHLVACIISTVVTAILCGAITDKTRQIKPIIVISSIFGVVGAGILTLLNNNANNSAHIGLLILPGVAFGGLAQSSMLASQIQLDKKSPTFRSDFVSITTFNTFCKNLGQALGGVISNTVFSAAAIKKLTKANIQLPDGTTVDNLVIYRQTNFDGSHSKLGNIISESLTDVFYMALGFYALSLIFAVFASNKKVTASLR
InterPro domains: - IPR011701: Major facilitator superfamily (family) [73-345]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [68-610]
- IPR020846: Major facilitator superfamily domain (domain) [69-608]
Interaction partners: - Probable transporter AQR1
- Uncharacterized transporter YMR279C
- Polyamine transporter 2
- Aminotriazole resistance protein
- Fluconazole resistance protein 1
- Oligomycin resistance ATP-dependent permease YOR1
- ABC transporter ATP-binding protein/permease PDR18
- Quinidine resistance protein 3
- Protein SNQ2
- Polyamine transporter 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015174 (basic amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0003333 (amino acid transmembrane transport), GO:0072337 (modified amino acid transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015807 (L-amino acid transport), GO:1902475 (L-alpha-amino acid transmembrane transport), GO:1903826 (L-arginine transmembrane transport), GO:0015802 (basic amino acid transport), GO:0046942 (carboxylic acid transport), GO:1990822 (basic amino acid transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)