wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Teleost multiple tissue opsin b (A0A2R8Q4C0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004951}.
Sequence: MWQQCSCALGELQNHRNDGLENSPKLKWITKHSRYKTKLIKSFTQAIINGAMIESNVSRSCEWCAGGGEGTGAHLDENHSDHSLSPTGHLVVAVCLGFIGTFGFLNNTLVLVLFCRYKVLRSPMNCLLISISVSDLLVCVLGTPFSFAASTQGRWLIGRAGCVWYGFINSFLGVVSLISLAVLSYERYCTMMGSTQADSTNYRKVVIGIAFSWIYSMVWTLPPLFGWSCYGPEGPGTTCSVNWAARTPNNVSYIVCLFVFCLILPFIVIVYSYGRLLQAITQVSRINTVVSRKREQRVLFMVVTMVVCYLLCWLPYGIMALLATFGHPGLVTPAASIVPSLLAKSSTVINPIIYIFMNKQFCRCFHALIMCTTPERGSSFKNSSKVTKTLRTVRRANGQNVTFAVASAVHRTPYSDRQKSSSEGEKLPPATGQGTSKPVVSLVAYYNG
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [106-354]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [91-362]
- IPR002962: Peropsin (family) [110-340]
- IPR001760: Opsin (family) [112-345]
- IPR050125: G-protein coupled receptor opsins (family) [79-373]
- IPR027430: Visual pigments (opsins) retinal binding site (binding_site) [338-354]
Interaction partners: - SKI-like proto-oncogene a.
- COP9 signalosome complex subunit 9
- NAD kinase b.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0009881 (photoreceptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0097730 (non-motile cilium)
Protein: Transcription factor ZEB2 (Zearalenone biosynthesis protein 2) (I1RFC6)
Organism: Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum)
Function: Transcription factor that specifically controls transcription of the zearalenone biosynthesis cluster genes.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Sequence: MQSTESFHALPTRSDVEDPNERRKIQNRIAQKKHRQKMKRRIEELETKVNNQCQTSNWTSHAPTDSCQEQQFLDNTDFGLMLEDDLLYRELSASLDGAGLTAVAQMHDSPRPNQQQRLSVSGMPSSPTSTSNVAQRGLSIGDHSSASNHLSSLSLVPGSTEGSLPTRQHDNLCNQDLRDMVPEEKMSRILKVIQDAGYKDMDSFMTEYYVRDFDASSHVSAVQRQSRSRRLRGFLEQLRVGAESWSDYEAHDYQQEISKSAEAIYAKELDVFSTTTLGENASFQGLASLYRVLQSTVGSDIENHLRHEQSMMQRQVSEIVHRQVYTFNPAQC
InterPro domains: - IPR004827: Basic-leucine zipper domain (domain) [22-37]
- IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [18-53]
- IPR052635: Secondary Metabolite Biosynthesis Regulator (family) [14-145]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0009404 (toxin metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043385 (mycotoxin metabolic process), GO:0009403 (toxin biosynthetic process), GO:0045122 (aflatoxin biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0043386 (mycotoxin biosynthetic process), GO:0046222 (aflatoxin metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Serine repeat antigen 1 (EC 3.4.22.-) (O96167)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MKFFIPYVYIICVIFIINVIRTRGEEDDDNNNISGKSILGTSHNNISNIDLSSIPNLDSNIHASFSSDTKEWSPNNLTSKKKKKKKEIRPKDIMSNSDSSNTSSINKQNNNQIKSVLLKENKGVKITGPCNVNLSIFLVPHIYIDVETKYNNIELKYELDEFSDSIKFKDTTTELRTSDDTLMNTNFNVGVSRDTLDKDRLYNICAENKTFKFVVYIKDNILTLKWKVYETGVTNNKVDIRQYKMKELTRPITTIQIHSVSENKDTHLLESKNYVIKTDIPETCDVMATNCFLSGNINIEKCLECTLLVQNNDTSSECFTYVSNDVRENFNQIKAEAEDDENFRNYHLTDTINNILKRIYKINKNEGKKELITLEELDNFLKESITDYCKILREIDTNGTLVNHELGNNVDVFNNLIRLLKLHKNESISTLHNKLRNSAICMKYPDKWIEKKTGLILPNVVNNNIIYNNKYEKLNEEKKRKIYDNKDDSKISDIINIKKYIFTNNTLKYFNNDKQFCNSSFCNRLKDENNCISKIQIEDQGNCAISWIFASKYYLETLKCMKGYEPHAISALYIANCSKRKHKNRCNVGSNPLEFLQIIEENQFLPMDTNYLYSYTKVGNDCPDEEKNWVNLLKHTRMLNYNNKHRSTLSTKAYRAYESEHFKDKMDTFIKLIKDEIMNNGSVIAYVKAENVLGYELNGKNVQNLCGDKTPDHAVNIVGYGNYINDEDEKKSYWIVRNSWGKYWGDEGYFKVDMYGPSTCEDNFIHTVVVFNINMPKSKKSPVKITFPLYNYYLKYSPDFYHNLYYKNFNSKKSMKLVNASDEHKNIYSQEDKVNHKKGSKILNSEVTTSLLSQEISQRRGEDDDIDTLIGDSPDINEQEKNIKDEFNKSSITHNSVSSSNITKSNKNTNKVKIYHIIKHVKNTKIKIGFVKYDNYNTIGTNHTCSRSYSEDQEKHEGCIKFCELHWNECKDKTSPGYCLTKLKGSNECFFCYV
InterPro domains: - IPR013128: Peptidase C1A (family) [459-753]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [525-771]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [495-776]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [733-752]
Interaction partners: - Uncharacterized protein
- Serine repeat antigen 3
- Cysteine proteinase falcipain 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0050776 (regulation of immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043657 (host cell), GO:0043227 (membrane-bounded organelle), GO:0033643 (host cell part), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0020003 (symbiont-containing vacuole), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part)
Protein: C3H1-type domain-containing protein (Q388W9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSSQDNRAKYVQNGVMEVFDPNFKYLYLVPAHFVLHVPPARLNISRLVICRNYRSGVPNSCAKEESCRFVHADVDYSTLEAHPIHVNYIWRHEDHCTYERLPAGDVLEVCSQENPQEHELISSELVLVTRGSVAHHNALPHSLMRCPLYTTNRMCSRGERCSFIHTLCVDPTVVGDFKRAPARTAAVTPTPRSPAVASATDSQKMPRTFASGTPMLSDFCISSPEREAPALSMGAGGYTALSFRVDAAGEPLPATCSVIPRCRVTARVRTSTVVKSRPTLVAAFSDASVSRRSAMATNSRPASYCHNPYYPVLCRS
InterPro domains: - IPR000571: Zinc finger, CCCH-type (domain) [44-168]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0010494 (cytoplasmic stress granule), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Glutathione synthetase (GSH-S) (EC 6.3.2.3) (Q86B44)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSSDANTAVLRNCIRLPLAEDELLEVTAKAKDYAIMHGAAMRSKTAFSPDSLNFAPFVLVPSSFPRKEFEKAVALQPIINRLMHNVAHDEEFITTTLAETIKVDEFTANLFNIYRKVLAHGFTQKTSLGMLRSDLMLESGCPELSPRALRTAAGEDRGQDAGAAVGQIAGANGAAGVGTAAGTGSKEEEHREVQLSRVTKEPERRATGAQSAYCCWKQVEINTIASGFGHLGPASKTIQRFVLSELGHADKLHNMPDNNALAGLCDGMVKAWDIYAKPQAVILFIIEDVSYNICDQRFHEFYIRETYPHIKVLRRTLTEVHREGKLGQSKELLLGSQEVAVIYFRAGYEPGHYHSQADWDARYLMETSLAIKCPSIHYHLAGTKKVQQALAQPAVLERFINDPEEIKAVGKIFTGLYSLDDNEAGNASYEMALRTPERFVLKPQREGGGNNVYGVDIPDALKRMSRVERSAWILMDLIHPPLTKGYMVRPGGDMPPQIVDMVSELGIFGVVIGDAEHIVHNYQAGHMLRTKLSTANEGGVAAGLGALDSPYLIDSDDEDEQK
InterPro domains: - IPR016185: Pre-ATP-grasp domain superfamily (homologous_superfamily) [279-383]
- IPR005615: Glutathione synthase (family) [1-553]
- IPR014709: Glutathione synthase, C-terminal, eukaryotic (homologous_superfamily) [416-472]
- IPR004887: Glutathione synthase, substrate-binding domain (domain) [280-381]
- IPR037013: Glutathione synthase, substrate-binding domain superfamily (homologous_superfamily) [234-370]
- IPR014042: Glutathione synthase, alpha-helical (homologous_superfamily) [75-415]
Interaction partners: - Glutamate--cysteine ligase
- GCS light chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006749 (glutathione metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006750 (glutathione biosynthetic process), GO:0006518 (peptide metabolic process), GO:0043043 (peptide biosynthetic process), GO:0019184 (nonribosomal peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Negative elongation factor complex member E (E9PD43)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Chromosome {ECO:0000256|ARBA:ARBA00004286}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRKSLYESDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLY
InterPro domains: - IPR033102: Negative elongation factor E (family) [1-217]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0005886 (plasma membrane), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: SET domain-containing protein (O45995)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MQPSTVPTETLQSRMSGFNERLKKATNVTEQVAVMEDMKKDSEVYDSWSKHRQAQLKYAYTSFPTKFREMMGGSSIREEETEEIDTQNSSETEEPSIADAIASRQEFLNKLVETTDQLIDITVDKFISQLKNCHIRKPETPSEPSREASPAPRLSSPFERIIDETTELLAKCASSGPPDHSLRSSILETLFSEIKGKSSDVSLVTISEESEKSEESEESKEDKGSQSLNTSSISTEPSPVQTSILKPPPMYPETASFPHRKIRSGAYSLYPPPQPSQQFVHSHNFHQPKFDASSMLSTGYCPSRNVATFKVDKPYGTVFTYDHQNRKFQEHCCVECREQIEENDLYPLYAVWCEKISNHVIFMEIGFTEEIGQFVFSFKTGGFEQVDFPELVFSEHVEYNGSFVAMIAGEGEDKVIIERDESGEKVRKLLHKFGHSVQIPYAPVRPLWMQKAEEPVEEDVEPESDAEPEETLDAEHVSYITSLPTYKKEYCQTYEMDVLYMLQPNGQYLKYSLNDDENELNLHVCDCCKTGTTENDLIPKYSEYCAKTCKYIIHVQNQFTEKMETYAYDCEKKRFHQVTCPGLVYDSEKVQEGNIFFILEQNSMQGVEVIMRDDDGQLRKEQFCMVKKQFVKLPKTTVATFAVQIAEKKMKNLLPNVEIFLPWPQRFTPSLSQCSSVQAMVIPETNHQLISSPQPTPSEID
InterPro domains: - IPR039908: Protein sepa-1 (family) [250-699]
Interaction partners: - Protein atz-1
- DUF1624 domain-containing protein
- CABIT domain-containing protein
- Cilia- and flagella-associated protein 157
- F-box domain-containing protein
- F-box C protein
- F-box domain-containing protein
- Major sperm protein 63
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Putative F-box protein At3g13830 (Q9LRW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MTTTTTTTMSTLPMVLVDEILSRVPITSLRSLRSTCKRWEAQSKTNLVGGKATARKSSYLGFILIGNKICSMKLDLNGGDDFVDTSVNQISAFDDFEISQLFHCDGLLLCVSNKHYYSNTVMVCNMYLGETRLIEHCCLLEGFDNFGSYAFGYDSSKNRNHKIFRKKLVSGGYEIYSFKSDSWKDLNVDLGESTELCELGSVSLKGNAYFSVITKHEEEELWENNLLCFDFTTESFGKFLSLPFDNVTAEEEFGIMVLSCVRDEHLAVLYQLDTLGIWISTEIEPNKVSWREFLQVDLYTLDGFPDAFTAGRFIVDEEKQVVVVFNEATEIDLNHGNAFIFGRDGYFTSFNVGDTPPQDFTSYVPSLASLQIEKTGG
InterPro domains: - IPR006527: F-box associated domain, type 1 (domain) [201-366]
- IPR017451: F-box associated interaction domain (domain) [102-327]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [7-65]
- IPR001810: F-box domain (domain) [6-43]
- IPR050233: Arabidopsis thaliana F-box (family) [13-325]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0010286 (heat acclimation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Acyltransferase PapA3 (EC 2.3.1.278) (EC 2.3.1.279) (Long-chain-acyl-CoA--trehalose acyltransferase) (Mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) (Polyketide synthase-associated protein A3) (P9WIK5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Involved in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid that could have a role in anchoring the bacterial capsule. Catalyzes the sequential transfer of two palmitoyl groups onto a single glucose residue of trehalose generating the diacylated product 2,3-diacyltrehalose (trehalose dipalmitate). Although palmitoyl-CoA (PCoA) seems to be the physiological acyl donor, PapA3 can also use docosanoyl (22-carbon saturated fatty acid) coenzyme A as acyl donor.
Sequence: MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQNTPDPLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAALVGGHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAGAAPLSVLLTAELTGTNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIARESVARYLATLKSVFQRVAESGQQQNVA
InterPro domains: - IPR001242: Condensation domain (domain) [54-468]
- IPR023213: Chloramphenicol acetyltransferase-like domain superfamily (homologous_superfamily) [42-229]
Interaction partners: - Mycolipanoate synthase
- Acyltrehalose exporter MmpL10
- Phthioceranic/hydroxyphthioceranic acid synthase
- Probable multifunctional mycocerosic acid synthase membrane-associated Mas
- Mycocerosic acid synthase-like polyketide synthase
- Polyketide synthase Pks13
- Mycoketide-CoA synthase
- Phenolphthiocerol/phthiocerol polyketide synthase subunit C
- Sulfolipid-1 exporter MmpL8
- Phenyloxazoline synthase MbtB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0008610 (lipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Carboxysome shell protein CcmK3 (Carbon dioxide-concentrating mechanism protein CcmK3) (P73406)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: A probably minor shell protein component of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. This subunit probably does not form homohexamers.
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00854}. Note=This cyanobacterium makes beta-type carboxysomes. {ECO:0000305}.
Sequence: MPQAVGVIQTLGFPSVLAAADAMLKGGRVTLVYYDLAERGNFVVAIRGPVSEVNLSMKMGLAAVNESVMGGEIVSHYIVPNPPENVLAVLPVEYTEKVARFRT
InterPro domains: - IPR046380: Carboxysome shell protein CcmK (family) [1-103]
- IPR020808: Bacterial microcompartments protein, conserved site (conserved_site) [21-40]
- IPR050575: Bacterial microcompartment shell (family) [2-97]
- IPR000249: Bacterial microcompartment domain (domain) [3-82]
- IPR044872: CcmK/CsoS1, bacterial microcompartment domain (domain) [4-91]
- IPR037233: CcmK-like superfamily (homologous_superfamily) [1-103]
Interaction partners: - Carboxysome shell vertex protein CcmL
- Carboxysome assembly protein CcmM
- Carboxysome assembly protein CcmN
- Ribulose bisphosphate carboxylase large chain
- Ribulose bisphosphate carboxylase small subunit
- Carboxysome shell protein CcmK4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031469 (bacterial microcompartment), GO:0031470 (carboxysome)