Protein: Ras GTPase-activating-like protein IQG1 (Q5AH02)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis
Subcellular location: Bud neck. Note=Forms a ring at the bud neck in a MLC1-dependent manner, which contracts at the end of cytokinesis
Sequence: MAIGNIAARYLSSLEETDTTATTTTTTTSNVLQPSNRLNSPTKFNRKSLDNNSQDLDALARALNITPSKPETPTSISKGSATSLLRTKFESPSATVSSFKSTSSSNGVSPTKKNHFVEITSDETPSWANKNYKDILNKSPTKFNTQSNVHTPLKQLNQPIGTPSSSSLSPAKNASKSSPGYEYLCRIEAIKQWLESVLQEQITQSASQLISYIRNGIHLAKLANVVLPTSKPVFLNDSKLQFKHTENINRFFQLLDFFNMPDLFRFELTDLYDAKNVPKVWFCLHALSYILHKQDPSYPAMNNLVGKVDFSADDIRTANRALVNSPLPNFSSADTGEGKSDTSNNNSSTTSATAAFMDKVTSPVKKTPSPLKRPQQLQKKQLELVEDNKPELTQDSSGLSKISRDDPFTDRVDLAPPSTSNAKLELHTPPSKSLEFKIKSPIIDLSHRDSDYYTPELESHLPNIIKFQSLARGAVFRYLMFVDRILLKSYQDEFTNLFAIIRGNKARRKTVHKHRDELRLYSFEIIELQSIIRKNFVINKKPNFTSITNDVETVELQSLIRGKLTRDWKKYVTNGLEKFTPQIIDFQSLVRMKSIYSKSNKVISYKDEILPSLIELQSIARSQLYHRFSRSNAIDETEIIKIQSIIRRNAVIEDLYTKLSKVRSNKRRLIELQSIARGGVARTKLCNSVLVTLIYEDGILNQLFAKIRGDNYRKKFNSQKSELLKYEKSSIIPVQTLFRGVLSRYTKEVTLSDIFDQIDSVITLQSVARGKLMRGSIYEFSDYYQKHIKQVVKAQAILQRVFAQNAYKQLITSKNPPLKVIRRFAPLLSNNDRDFQDEMTLSDLKDLIIEKCKANEEYENQIEQLDMKLGLLDKNKISIEEFLKPTKGKTFKPIVENVKNLERLNKSLKKKIELWQTLFYFIQTNPIYLTKLFNSIPYTKNQTKSGQDLFQSVIQLFPVRDSSITYHSREEYFLVKLMIQLMQNDTANSNNLGDITKLHLTNWIDFFTNFNNHTFQRQHLKALLGKFVIRIVDNEQVDFESDPIRIYNQIIDHEMKVYGRSEKSRDISPQAAIQLPEVSNKFVGNLMSLRETCSDLLSMLQKNASGNKALLQIPDHVKLICRQGYLCAQRKFPDKSDQQHLAVAGVIFVKHYLGSILQVPENYGILTGNNDTQKAKSKDNLRYLYRVMLQLFSMKPFNDNFLKPLNEYIMASTDTVKSIISQAIINVGEIETVYELHDYDDLVTHQRPKLTISVNSLIQLEKSILQNVDIITTGNDDQLYKTCVEVEKLLISPQDMLTLTDLSSVTLNLNPTTQEESIVDSKTKTLFTQAKRCLLYIIRVQEEDDSDDLLELLISGIKPSHEQRFKEIVQYEKAEQDISLNNSKSVTANTVNKKKSTRPYSGTSLGDLSNLTYHELKKMCLEIILKLESMGELTRKNSFQTLLNQIAMDIKTKDSQRQCRWQQLQVSQKTIKKLSEKENYLKTQLHNYKKHVESVLLELQSKSKSNDKNWKRRLFNIMVIPVFSKQYFYHRELRKHNRLPKFGSYKYSAKKLIDQKVLIDFSTANNVATASKLDFMFSCHQVGKFTIEVASGTVNIPGATNTITLDELLALQYENKTKFELFDGMATFDSNNFMGLIFRKFYDLKKE
InterPro domains: - IPR001715: Calponin homology domain (domain) [184-291]
- IPR000593: RasGAP protein, C-terminal (domain) [1413-1563]
- IPR001936: Ras GTPase-activating domain (domain) [979-1193]
- IPR036872: CH domain superfamily (homologous_superfamily) [172-330]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [902-1298]
Interaction partners: - Rga2p
- Myosin 1
- Formin-binding protein
- Mlc1p
- Cell division control protein 42 homolog
- Cell division control protein 42 homolog
- Inn1p
- Actin
- Cyk3p
- Formin BNR1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0070938 (contractile ring), GO:0032153 (cell division site), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005826 (actomyosin contractile ring), GO:0043229 (intracellular organelle), GO:0005935 (cellular bud neck), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0110085 (mitotic actomyosin contractile ring), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030864 (cortical actin cytoskeleton), GO:0015629 (actin cytoskeleton)