Protein: LIM domain-containing protein D (Q9BIW4)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Binds to F-actin and may modulate the chemotactic response during early development and contribute to the maintenance of the strength of the actin cytoskeleton.
Subcellular location: Cell projection, pseudopodium {ECO:0000269|PubMed:12374734}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12374734}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12374734}.
Sequence: MSNLGKCTRCQKTVYSQEGFIAVKVPFHRSCFKCEVCNWQLVLTNYKSINGKVYCANHYPVGGLSVTPEKTHTTSDDLVMKNALNAPRVETVNEQLRGGNEKPQTSTDDLVTKNALNAPKSNLVNNQVRGTSDSAPLTSADDLVTRNALKAPKSDLVNNQVRGTSEMGPQAGIDIVTANALKAPKLETMSGYQKSVQN
InterPro domains: - IPR001781: Zinc finger, LIM-type (domain) [5-65]
Interaction partners: - Paxillin-B
- SAP DNA-binding domain-containing protein
- Calponin-homology
- Ankyrin repeat-containing protein
- Phospholipase D B
- LIM domain-containing protein C
- Uncharacterized protein
- Calcium-regulated actin-bundling protein
- LMBR1 domain-containing protein 2 homolog B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048870 (cell motility), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048523 (negative regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0032970 (regulation of actin filament-based process), GO:0031589 (cell-substrate adhesion), GO:0016477 (cell migration), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0030030 (cell projection organization), GO:0030866 (cortical actin cytoskeleton organization), GO:0043244 (regulation of protein-containing complex disassembly), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0030835 (negative regulation of actin filament depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:1901879 (regulation of protein depolymerization), GO:0030031 (cell projection assembly), GO:0110053 (regulation of actin filament organization), GO:0030832 (regulation of actin filament length), GO:0120036 (plasma membrane bounded cell projection organization), GO:1901880 (negative regulation of protein depolymerization), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0031268 (pseudopodium organization), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0030865 (cortical cytoskeleton organization), GO:0032060 (bleb assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)