Protein: GTP cyclohydrolase MptA (EC 3.5.4.39) (GTP cyclohydrolase I) (GCYH-I) (GTP cyclohydrolase IV) (D4GWJ7)
Organism: Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Function: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin (By similarity). Involved in archaeosine (G(+)) and folate biosynthesis.
Sequence: MSHQLPDVQASQPDVTVGLSQVGVTGVEKLVKIARDGKRPLVLMAEFEVFVDLPGGRKGIDMSRNMQVIDEVLEAAVSEPAYRVEDMCGDAAERLLAKHEYTTTAEVSMTAELVVREDTPASGLSTQSTAEIIASATATDEGTREEIGAEVVGMTVCPCSQGMSASRARDVLQDLAVDDDTIEEFLDKVPQPGHSQRGHATLTVETQGSPEVDLMDLIDIARDSMSARIYNLAKRPDEDHMTYHAHANAKFVEDCVRSMAELSLEALDHLGDDAVVHMKQSNDESIHQHNAHAEREVTLGQLRDELDA
InterPro domains: - IPR022840: GTP cyclohydrolase MptA (family) [4-306]
- IPR003801: GTP cyclohydrolase FolE2/MptA (family) [2-304]
Interaction partners: - Probable GTP 3',8-cyclase
- Pyruvate kinase
- 6-carboxy-5,6,7,8-tetrahydropterin synthase
- CobW domain protein
- Nucleoside diphosphate kinase
- Adenylate cyclase domain protein
- PtpS family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0046872 (metal ion binding), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0046914 (transition metal ion binding), GO:0019238 (cyclohydrolase activity), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0042559 (pteridine-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)