Protein: Homeobox protein DBX1 (Developing brain homeobox protein 1) (P52950)
Organism: Mus musculus (Mouse)
Function: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.
Subcellular location: Nucleus.
Sequence: MMFPGLLAPPAGYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPPTYLSRSIPAASLSPPSQEAPAALADSGTSDLGSPGSGSRRGSSPQTALSPASEPTFLKFGVNAILSSAPRRETSPALLQSPPPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKTFQKQKYISKPDRKKLASKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGDEEEDNPGARLAYHAPADPRHLLEGPLPASPAHSSSPGKPSDFSDSDEDEEGEEDEEITVS
InterPro domains: - IPR001356: Homeodomain (domain) [179-243]
- IPR020479: Homeodomain, metazoa (domain) [203-237]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [158-239]
- IPR017970: Homeobox, conserved site (conserved_site) [214-237]
- IPR000047: Helix-turn-helix motif (conserved_site) [210-235]
- IPR051662: H2.0 Homeobox Neural Patterning (family) [1-335]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0031018 (endocrine pancreas development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0045165 (cell fate commitment), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0035270 (endocrine system development), GO:0003309 (type B pancreatic cell differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0030858 (positive regulation of epithelial cell differentiation), GO:0010468 (regulation of gene expression), GO:0003309 (type B pancreatic cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0002064 (epithelial cell development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0031016 (pancreas development), GO:0030855 (epithelial cell differentiation), GO:0002066 (columnar/cuboidal epithelial cell development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0002068 (glandular epithelial cell development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0002068 (glandular epithelial cell development), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0002067 (glandular epithelial cell differentiation), GO:0035883 (enteroendocrine cell differentiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0035883 (enteroendocrine cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)