Protein: Dendrocyte expressed seven transmembrane protein (D3ZVC2)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MGLWALGTSVFLRLWGTYVFPGSTAWTNFIQHLGVCCFVALLSVSLLSAALYWVLPSAALLSAVWMATCVFLCCSKHARCFILLAIVSCGLREGRNTLLAAGTGVVIFGHVENIFSNFRGLLDSMTCNLRAKNFSTHFPLLKRYIEAIEWIYGLTTPLNVLDDLVSWNQTLAVSLFSPSHALQAHMNDTRGEVLSVLHRMVLTTELLTSVGQKLLALAGLLLILVSTGLFLKRFLGPCGWKYENVYITRQFVLFDEEERCQQRPCVLPLNRKERKKYIIVPSLKLTPKERRNLGLFFLPVLTYLYMWMLFATVDYLLYRLISSVNKQFQSLPGLEVHLRLHGEKQGTHGVIHDSAFNISMFEPSCILKPRLSVSQTWVPLSIILLTLVILGLLSSMLMQLKILVSVSFYPKVERERIEYLHAKLLEKRSKQPLGEADRKLSLYFKKIHFWLPVLKMTRKKHMIPANEDDP
InterPro domains: - IPR012858: Dendritic cell-specific transmembrane protein-like (domain) [242-421]
- IPR051856: Cell Surface Receptor and E3 Ligase Protein (family) [144-458]
Interaction partners: - Osteoclast stimulatory transmembrane protein
- Cathepsin K
- Nuclear factor of activated T-cells 1
- Tumor necrosis factor ligand superfamily member 11
- V-type proton ATPase subunit d 2
- Matrix metalloproteinase-9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0031323 (regulation of cellular metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0031325 (positive regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0008284 (positive regulation of cell population proliferation), GO:0034097 (response to cytokine), GO:2000648 (positive regulation of stem cell proliferation), GO:2000379 (positive regulation of reactive oxygen species metabolic process), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0071310 (cellular response to organic substance), GO:0072091 (regulation of stem cell proliferation), GO:0071345 (cellular response to cytokine stimulus), GO:0034612 (response to tumor necrosis factor), GO:0071356 (cellular response to tumor necrosis factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)