Protein: Trehalose-binding lipoprotein LpqY (P9WGU9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. No binding affinity for maltose
Subcellular location: Cell inner membrane; Lipid-anchor; Periplasmic side
Sequence: MVMSRGRIPRLGAAVLVALTTAAAACGADSQGLVVSFYTPATDGATFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTAEFAEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPDLVNSPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDGRHVTLTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNWPFVFASMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFAPYPAVAPGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVRASLYSDPQFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTADELAAQAQKAIDGMGLLP
InterPro domains: - IPR006059: Bacterial-type extracellular solute-binding protein (family) [42-373]
Interaction partners: - Trehalose transport system permease protein SugB
- Trehalose transport system permease protein SugB
- Trehalose import ATP-binding protein SugC
- Trehalose import ATP-binding protein SugC
- Trehalose transport system permease protein SugA
- Trehalose transport system permease protein SugA
- Trehalose import ATP-binding protein SugC
- Probable transmembrane protein
- Probable sugar-transport integral membrane protein ABC transporter UspB
- Probable sugar-transport integral membrane protein ABC transporter UspA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0043178 (alcohol binding), GO:0090482 (vitamin transmembrane transporter activity), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0051119 (sugar transmembrane transporter activity), GO:0043177 (organic acid binding), GO:0007154 (cell communication), GO:0031406 (carboxylic acid binding), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0008643 (carbohydrate transport), GO:0015772 (oligosaccharide transport), GO:0015766 (disaccharide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0051179 (localization), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0008643 (carbohydrate transport), GO:0015772 (oligosaccharide transport), GO:0015766 (disaccharide transport)