Protein: Integrin beta (A0A8M6YW86)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium. Cell projection, ruffle membrane; Single- pass type I membrane protein. Melanosome
Sequence: MDLKLLFISALLGIISCSHAQQEGNECIKANALSCGECIQVGDKCGWCTDAEFLKQGEPTSARCDELESLKKRGCAEDKIENPHGSQRILKNTPVTNRKKGAEKLRPEDITQIQPQKLSLQLRSGEPQNIKLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKNLGTSLMKEMSKITSDFRIGFGSFVEKTVMPYISTTPAKLLNPCTGDQNCTSPFSYKNVLKLTSNGQRFNSLVGQQQISGNLDSPEGGFDAIMQVAVCGEHIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGRCHLENDMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVINLIVDAYNSLSSEVILENSKLPEGVTITYQSRCKNGVVNEGESGRKCSNISIGDEVSFNINITAQGCPKQGKTETIKIKPLGFTEEVEITLSFICECECHKHAMKNSPLCHNGNGSFECGACRCNKGRVGRQCECRKDEVSTEDLDKNCRKDNGTDICSNNGECVCGTCECKKRENPEERYSGKYCECDNFNCDRSNNKLCGGHGRCECRVCVCDANYTGSACDCSLDTSTCLASNKQICNGRGICECGTCRCTDPKFQGPTCEICPTCPGVCTEHKECVQCRAFGTGEKKDTCKRDCSYFNLIEVEDRDKLPQPVQAFPLMHCKERDARDCWFYYTYAVNNNTEKEVHVVKTMECPPGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTTENPIYKSPINKFQNPNYGRKAAAL
InterPro domains: - IPR040622: Integrin beta, epidermal growth factor-like domain 1 (domain) [466-495]
- IPR057243: Integrins beta, I-EGF domain, conserved site (conserved_site) [607-620]
- IPR015812: Integrin beta subunit (family) [8-798]
- IPR014836: Integrin beta subunit, cytoplasmic domain (domain) [752-798]
- IPR012896: Integrin beta subunit, tail (domain) [639-728]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [137-379]
- IPR013111: Epidermal growth factor-like domain, extracellular (domain) [599-630]
- IPR033760: Integrin beta N-terminal (domain) [25-75]
- IPR036349: Integrin beta tail domain superfamily (homologous_superfamily) [638-726]
- IPR057073: Integrin beta, epidermal growth factor-like domain 2 (domain) [511-554]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [350-468]
- IPR016201: PSI domain (domain) [26-76]
- IPR002369: Integrin beta subunit, VWA domain (domain) [34-464]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0001968 (fibronectin binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:0003170 (heart valve development), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0003179 (heart valve morphogenesis), GO:0048513 (animal organ development), GO:0048731 (system development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045766 (positive regulation of angiogenesis), GO:0003171 (atrioventricular valve development), GO:0045765 (regulation of angiogenesis), GO:0072359 (circulatory system development), GO:0003181 (atrioventricular valve morphogenesis), GO:0007507 (heart development), GO:1901342 (regulation of vasculature development), GO:1903670 (regulation of sprouting angiogenesis), GO:1903672 (positive regulation of sprouting angiogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0098636 (protein complex involved in cell adhesion), GO:0043235 (receptor complex), GO:0005737 (cytoplasm), GO:0098636 (protein complex involved in cell adhesion), GO:0120025 (plasma membrane bounded cell projection), GO:0098802 (plasma membrane signaling receptor complex), GO:0031410 (cytoplasmic vesicle), GO:0098802 (plasma membrane signaling receptor complex), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0098797 (plasma membrane protein complex), GO:0098590 (plasma membrane region), GO:0008305 (integrin complex), GO:0043227 (membrane-bounded organelle), GO:0008305 (integrin complex), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098978 (glutamatergic synapse), GO:0043005 (neuron projection), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0045335 (phagocytic vesicle)