wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Gamma-tubulin complex component 3 isoform X1 (F1QA15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Sequence: MATLDQKSPNVLLQSLCCKITGKSEADVAHQFQYAVRVIGSNYAPTIERDEFLVSEKIKKELLKQRREADAALFSELHRKLQTQGVLKHRWSILYLLLSLCEDPRKPSGRVPVCSYGALLAQALPRDVHSTPFYYARPQSLPLSYPERSATAHNSSMATSGISSMGVFSINGPGPTPPSLLTGAGTQAVGESMRGSRLAWTLPVSSSPSGAAAAPRPPSGPSSSPAPKPLQRPRRDGDGSADIGEAALVRDILYVFQGIDGKFIKMCSPENCYKIDSKVPLCKSLRDTSSRLAELGWLHNKIRKYTDSHSLDRAFGLVGQSFCAALHQELKEYYRLLSVLHAQLQVEDDQGVNMSVDSSLTLRRLLVWTYDPKVRLKTLAALVDYCQGRKGGELATAVHAYGKTGDPNMRALIQHILGLVSHPILNFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYSLRKSMIPSFITMDQARKVLLIGKSINFLHQVCHDRTPPGKIMPASKSKDSPKDAAELFTDLEGTFQSKIDAAYFETSKYLLDVLNKNYQLLEHLQAMRRYLLLGQGDFIRHLMDLLKPELARPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVEGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIWKGQMCNAKLLKSMPELSGVLHQCHVLASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHDVFLDTIISRCLLDVNNRSLLNQLRAVFDQIIEFQNAQDTLYRSALEELQLRIQFEDKKRQREEMAEWGVTAEQEAEENRRVQEFKDTIPKMCSQLRLLTHFYQGIVQEFLRLLMTCSDESLQFLSFRLDFNEHYKARDPRLRPSLGATRGRRSSNI
InterPro domains: - IPR040457: Gamma tubulin complex component, C-terminal (domain) [553-884]
- IPR007259: Gamma-tubulin complex component protein (family) [60-885]
- IPR041470: Gamma tubulin complex component protein, N-terminal (domain) [249-549]
- IPR042241: Gamma-tubulin complex component, C-terminal domain superfamily (homologous_superfamily) [553-883]
Interaction partners: - Tubulin gamma chain
- Mitotic-spindle organizing protein 1
- Gamma-tubulin complex component
- Gamma-tubulin complex component
- Tubulin delta chain
- NEDD1 gamma-tubulin ring complex targeting factor
- Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Isobutyryl-CoA dehydrogenase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0043015 (gamma-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0048793 (pronephros development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000930 (gamma-tubulin complex), GO:0042995 (cell projection), GO:0036064 (ciliary basal body), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Mitogen-activated protein kinase kinase kinase 7 (A0A8M3AT57)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm
Sequence: MSMPSADMLETPPMYPFEEIDYVDIEVEEVVGRGAFGVVCKAKWKGRDVAIKTIESESEKNAFIVELRQLSRVDHPNIVKLYGSCNNPVCLVMEYAEGGSLYNVLHGAEPLPHYTASHAMSWCLQCSQGVSYLHGMKPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHRGTRPPLIKNLPKAIESLMTRCWSKDPSQRPSMEEIVKIMSHLMGYFPGSEEPLKYPYQYSDEGQSNSATSTGSHLDYTCTSNKNDINMEHTNSPGSNDTIKFPYKPKGISGQSLSRGSSVESLPGRSHFQPSSDSKRMSVELSELEPRLPFASPARPQYKRGHRKTASHGTILDIPKIIVTATCEPHRRRSVQDLPAIGTDASQDSRNNSRSSSPSFRMITPDRTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYLKVQTEIALLKQRKEELIAELDQDEKDQQNACRLAQEQKKLIEENKSLSTYYQQCKKQLELIRAQQQKRQGTS
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [141-153]
- IPR049637: Mitogen-activated protein kinase kinase kinase 7 (family) [1-578]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [25-272]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [13-281]
- IPR017441: Protein kinase, ATP binding site (binding_site) [31-52]
- IPR000719: Protein kinase domain (domain) [25-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: CXXC-type zinc finger protein 5 (A0A8M3AX14)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
Sequence: MSGGQPEGSRTPKAQDQDTDQDCGEDSPVIERRNRSGIISEPLSKSLKRSRTLSQYTAACPQTANGLKHNGQAKSHTAKPAQPAQQQPQQPSASALVPSKLDRTLEQVLEGQNGLLHFAQAAALLKRAGMEHMLLPGGMGVGVGGGEVGSVDLEGASVADTVGGHTDFPYGVGGGFPFNPGLFIMTPAGVFLADSALHMAGLTEYPVQSELASAISSGKKKRKRCGMCPPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ
InterPro domains: - IPR002857: Zinc finger, CXXC-type (domain) [218-259]
- IPR040388: CXXC-type zinc finger protein CXXC4/CXXC5 (family) [61-284]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0035295 (tube development), GO:0001525 (angiogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0009855 (determination of bilateral symmetry), GO:0060562 (epithelial tube morphogenesis), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0048562 (embryonic organ morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0002040 (sprouting angiogenesis), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0048793 (pronephros development), GO:0007368 (determination of left/right symmetry), GO:0001947 (heart looping)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Inhibin alpha chain (Q1LYE4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition
Subcellular location: Secreted
Sequence: MLTGTSSLSSFACALMLWALFSPPSVQACQGDELPCDMVLGWLKRRILEGLGLDEPPLPVLQLPTRQAGNRAVHHVASRMTRETRVERRHHQESSQVILFPSSESTCKDIPGHSSDAGPGHFTYYFQPSLDSQESIITSAHFWFYAGETIASINISAPLFILTHNKELLKASESPVKRSPDGWTTYKLDVHLHTPMADGQFMLQIRCPTCSCHDSEDKTPFLHLHTRSSGPDRSRRAPKIPWSPDAIENLKRPASQGTDCRREQIEISFEDLGWNNWIVHPKSFTFYYCHGNCSSAERITTILGITQCCAPVPESMKSLRFTTTSDGGYSFKYETLPNIIPEECNCI
InterPro domains: - IPR017948: Transforming growth factor beta, conserved site (conserved_site) [278-293]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [247-347]
- IPR015615: Transforming growth factor-beta-related (family) [29-346]
- IPR017175: Inhibin, alpha subunit (family) [16-347]
- IPR001839: Transforming growth factor-beta, C-terminal (domain) [233-347]
Interaction partners: - Serine/threonine-protein kinase receptor
- Serine/threonine-protein kinase receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0048793 (pronephros development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: 26S proteasome regulatory subunit 6A (Q6IQL5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus
Sequence: MSTEEIVQRTRLLDSEIKIMKSEVLRVTHELQAMKDKIKENTEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNMQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVCLDVNFEELARCTDDFNGAQCKAVCVEAGMIALRRGATELNHEDYMEGILEVQAKKKANLQYYA
InterPro domains: - IPR003960: ATPase, AAA-type, conserved site (conserved_site) [291-309]
- IPR003593: AAA+ ATPase domain (domain) [184-323]
- IPR032501: Proteasomal ATPase, second OB domain (domain) [77-130]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [140-393]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [343-385]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [76-139]
- IPR003959: ATPase, AAA-type, core (domain) [188-320]
- IPR050221: 26S Proteasome Regulatory ATPase (family) [2-397]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0001824 (blastocyst development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0045495 (pole plasm), GO:0043228 (non-membrane-bounded organelle), GO:0043186 (P granule), GO:0060293 (germ plasm), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Aldehyde dehydrogenase (X1WBM4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MEKQVVDGLREVFQSGRSRPLQYRKQQLRALLRLITERHADIEQALKQDLNRSMHGTSLFELIGIENDIKVAEREMTEWAAPRPVKKNLNSALDDVYVKPEPLGVVLIIGTWNYPWAMIFQPLVGAIAAGNAAVVKPSELSEHSSRLMKELLPLYLDKEMYQVVTGGVPETQELLKQRFDHIFYTGSSTVGKLVMEAASRHLTPVTLELGGKSPCYIDKNCDIAVACRRITWGKFANCGQTCIAPDYILCEPSIQDRIVEEIQKTLLEFYQTDPKSSPDYCRIINTRHFDRVLALMNECTIALGGENDRSQCYIAPTVLKDVLPHFKIMQEEIFGPLLPIVTVNGLSEAINFINAREKPLALYIFSSDKTVIKRMLKETTSGGVTVNDVLMHYTVDTLPFGGVGNSGMGRYHGKHTFDQLSHHRACLIKSFAMESLNDARYPPLTTARLRKAKFFMGHRMCSCNGMCVWAVIATVLAIGLLVGLLVVLI
InterPro domains: - IPR016160: Aldehyde dehydrogenase, cysteine active site (conserved_site) [235-246]
- IPR012394: Aldehyde dehydrogenase NAD(P)-dependent (family) [3-474]
- IPR029510: Aldehyde dehydrogenase, glutamic acid active site (conserved_site) [207-214]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [10-424]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [4-436]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [211-406]
- IPR015590: Aldehyde dehydrogenase domain (domain) [10-422]
Interaction partners: - 4-aminobutyrate aminotransferase, mitochondrial
- Amine oxidase
- Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- Acyl-CoA synthetase family member 3
- Glycerate kinase
- Glycine amidinotransferase, mitochondrial
- Cytosolic non-specific dipeptidase
- Acylphosphatase
- Amine oxidase [flavin-containing]
- Acetyl-coenzyme A thioesterase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006081 (cellular aldehyde metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Protein kinase C and casein kinase substrate in neurons 3 (A0A8M2BE23)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm
Sequence: MSSNGDLQDVGSWDSFWEPGNYKRTVKRIDDGYKLCNELVSCFQERAKIEKGYSQQLSDWARKWRGIVEKGSQYGTLEKAWHAFMNAADRLSEIHMELKENLVIEDSEKIRNWQKDAFHKQMIGGFRETKDADEGFRKAQKPWVRKLKEVESTKKGYHSARKEERTALTRETHAKADPTKSQDEVRKFTDRLEKCTQEAEKAKERYERALDELNRCNPRYMEDMEQVFEITQEAEKNRLCFFKEVLLDIHQHMDLSSNDRFRALYRDLGQTISAANDTEDLRWWRNTHGPGMSMNWPQFEEWSPEANRSISRKDRNSRSDDVVTLTNIVSAGDEPPQTLQETTRAGKDYSSDWSDEESPKKYIAANGVDEEEKVVGVRVRALYDYTGQEADELSFKAGEELLKLGEEDEQGWCKGQLTSGEKGLYPANYVQIITS
InterPro domains: - IPR001060: FCH domain (domain) [14-102]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [373-433]
- IPR001452: SH3 domain (domain) [374-435]
- IPR031160: F-BAR domain (domain) [8-280]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-302]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048568 (embryonic organ development), GO:0060034 (notochord cell differentiation), GO:0007399 (nervous system development), GO:0048562 (embryonic organ morphogenesis), GO:0048570 (notochord morphogenesis), GO:0030903 (notochord development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Tyrosine-protein kinase (Q6TPQ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol
Sequence: MGNCGSFDPDDEFSYHPDEWCDQCNCPKPPVSQNFDPLIPYPSQYTPPPSSPLPENLVVAIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAESLFTGQRGYIPKNFVAKLNSMETEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLCTRLVKPCQTRAPQKPWWQDEWEVPRESLKLERRLGQGQFGEVWMGLYNNNRQVAIKSLKPGTMSISAFLAEANLMKSLQHPRLVRLFAVVTQEPIYIITEYMENGSLVDFLKTPEGSDIPINTLIDMAAQVAEGMAYVEQKNYIHRDLRAANILVSHELTCKIADFGLARLIKNNEYTAREGAKFPIKWTAPEAINYGTFSIKSDVWSFGVLLTEIVTYGRIPYPGMTNPEVIANLERGYRMPCPDNCPEALYNVMKHCWTENPDNRPTFEFLRSVLEDFFTATEGQYQEQPC
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [56-165]
- IPR035749: Lck, SH3 domain (domain) [57-111]
- IPR001452: SH3 domain (domain) [53-114]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [111-257]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [238-486]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [225-491]
- IPR017441: Protein kinase, ATP binding site (binding_site) [244-266]
- IPR035850: Tyrosine-protein kinase Lck, SH2 domain (domain) [116-216]
- IPR000719: Protein kinase domain (domain) [238-491]
- IPR000980: SH2 domain (domain) [118-217]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [87-499]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [353-365]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [238-487]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: E3 ubiquitin-protein ligase E3D (F1Q7U1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site
Sequence: MEETANTDVLFIELRQKLQSGLLFIRSDVIGGGADVKIESKPDSILNVQTPDSSFQVTLTPGVSLVETQKQKSPANSEQGSHYRLRLKVEQPTESPCSVIGQLRVDESYSVLCQSCGSRVLQHRSFGRVLPLPNGNWNALVDDWCCHPDPFANRKLLPRAGDCLLGDTFILLLRDDGCDESLTRAAAEKRVLVSCRRCSTALGEEITAEVLKLYITEISVKPSEDGECDLTQLSLEPKSESVRQRFLEQTLASRLVELSAAQSIFRFSIQSPDGKAEILLWLLNTDTLVASFPAPAARADGFISVGDSHPRMHQSCQAVAAVKVLYILCSDSKLRDVVDVWEKDISVHPLPLPQRSCEELKTLLTSSTFRLPAFLRCMNSFQVAYMRM
InterPro domains: - IPR019193: Ubiquitin-conjugating enzyme E2-binding protein (family) [5-386]
Interaction partners: - DOP1 leucine zipper-like protein A
- Inactive serine protease 35
- rRNA-processing protein FCF1 homolog
- Cleavage stimulation factor subunit 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0030332 (cyclin binding), GO:0019899 (enzyme binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0044390 (ubiquitin-like protein conjugating enzyme binding), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)