wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Uncharacterized nucleolar protein C630.06c (Q9UUH6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
Sequence: METVKVTRKDLLLSPENKEIDSLDDVSALLSQRLSNVFEFSIASEEVQSDEVFEDTYPNDDQATFNLFSDVNTVVTKVTEPSIKNSRPLNYYILEDSPERQRQLQASVFTYDQLMKAKEEKWPACQKLHKVVSIKKEESKHRRRPSKKRRIRMKLLREKEEQLKRQAMAAKRNRFRKNVRKLPNKKKH
InterPro domains: - IPR018555: C630.06c-like (family) [8-186]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004519 (endonuclease activity), GO:0004521 (RNA endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Solute carrier family 25 (Mitochondrial carrier dicarboxylate transporter), member 10, isoform CRA_a (Solute carrier family 25 member 10 isoform 1) (A0A0S2Z3G3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAAAGDEPPPQGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRKNFGIKVPS
InterPro domains: - IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [8-293]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [8-291]
- IPR050391: Mitochondrial Metabolite Transporter (family) [7-287]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0005310 (dicarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006810 (transport), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0019318 (hexose metabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0016051 (carbohydrate biosynthetic process), GO:0071702 (organic substance transport), GO:0006811 (monoatomic ion transport), GO:0006006 (glucose metabolic process), GO:0019319 (hexose biosynthetic process), GO:0015711 (organic anion transport), GO:0015849 (organic acid transport), GO:0046942 (carboxylic acid transport), GO:0006094 (gluconeogenesis), GO:0006835 (dicarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: SD05495p (Q960D9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MALSVEIERVMDQGNCLMPDINICQSDLANPTEPIVTKIMVHYLRSFGFRLEPPYKIGTELGHSSREARVFLIRVCRQVERIVQISFPNKTYSYMDIIKPAVKKTLATLSYLFNHLAYYKVFKKKVLGPVEEAIKLKDSLTAEVKAKSQQLEQCSQKTKDCEMAINKLKKDLQDTQAKLLPLKKSCSEHENTLELIEQQQGELDKRIGHWEQLVVEDSQVTELREKIKSASSHVESCKTELASKKQVTNEHRRMIENSQHIATALEKATAVLSLCKVDDYKESFKQLEAVEKQLPTCKVNYQKLLQDAEAKKQELALCAHRYEERNQENDAENHKVQNELKKLQVDVEDRKKRLEDLNNHLIELDQQNLEQDQLYAILSEQIHEVLGQNWQMNST
InterPro domains: - IPR038275: Nuf2, N-terminal domain superfamily (homologous_superfamily) [5-166]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007059 (chromosome segregation), GO:1903047 (mitotic cell cycle process), GO:0007349 (cellularization), GO:0007051 (spindle organization), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0098813 (nuclear chromosome segregation), GO:0140014 (mitotic nuclear division), GO:0007052 (mitotic spindle organization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0007010 (cytoskeleton organization), GO:0000819 (sister chromatid segregation), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0051383 (kinetochore organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0000793 (condensed chromosome)
Protein: Cd209f protein (Q7TSU6)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: HEEQRMAGEPEFHQSKNHEEEVTSGEQGFAEHDPEGLICSSKSLQGHLTQVPWLLLLLISLGLFLLMLATLVQVSRIRAYSQGQTQDQQGSSSLDKVAVPREQTHSGLEQIQQIQQQLTQFNASLAGLCRPCPWDWELFQGSCYLFSRTLGSWETSASSCEDLGAHLVIVNSVSEQRFMKYWNVRKNQRSWIGLSDHIHEGSWQWVDGSALKFSFWKEGEPNNDGDEDCVELFMDDWNDNKCTEQNFWVCEQPSAPCPHH
InterPro domains: - IPR033989: CD209-like, C-type lectin-like domain (domain) [132-251]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [79-255]
- IPR018378: C-type lectin, conserved site (conserved_site) [229-250]
- IPR050111: C-type lectin and snaclec domain-containing protein (family) [106-254]
- IPR016187: C-type lectin fold (homologous_superfamily) [108-255]
- IPR001304: C-type lectin-like (domain) [132-252]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0048029 (monosaccharide binding), GO:0005537 (mannose binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009893 (positive regulation of metabolic process), GO:0009605 (response to external stimulus), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0019222 (regulation of metabolic process), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0098542 (defense response to other organism), GO:0010628 (positive regulation of gene expression), GO:0016192 (vesicle-mediated transport), GO:0042742 (defense response to bacterium), GO:0010468 (regulation of gene expression), GO:0006897 (endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Vasoactive intestinal peptide receptor 2 (Vasoactive intestinal polypeptide receptor 2 precursor) (Vasoactive intestingal polypeptide receptor type 2) (A7UH65)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MSLVNCLVLLIVWHAHSVNGRHPNCQFLYELQMAEKECLGDLADEPLLHTEGCRGMWDNFSCWHHADVGKVVVNNCPAALKNLFTRDGIISRNCTTEGWSNVYPSIDSVCFAPTNTNTTMYVFYTVMKTLYTLGHSLSLIALITGSTILCLFRKLHCTRNYIHLNLFFSFILRAIAVLVKDAILFSHENGECTVQPSLMGCKVSLVILNYFIMANFYWLLVEGLYLHTLLMVIFSENRHFIIYLLIGWGFPTVFVIPWIVCRIYLEDTGCWERIDNPIPWRVINWPIMASVILNFILFISIIRILVQKLRCPDVGGNDQSQYRRLAKSTLLLIPLFGVHYIVFVYIIDGNGERENYKIFFDLGLGSFQGLVVAILYCFLNSEVQSELKRKWRSLRLKRYIGRDYRLHSSSISRNGTENMAQFQRNTRAQSFLQTETTVV
InterPro domains: - IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [37-119]
- IPR047035: Vasoactive intestinal polypeptide receptor 2, 7TM (domain) [124-393]
- IPR017983: GPCR, family 2, secretin-like, conserved site (conserved_site) [53-383]
- IPR002284: GPCR, family 2, vasoactive intestinal peptide receptor 2 (family) [12-435]
- IPR000832: GPCR, family 2, secretin-like (family) [126-379]
- IPR001571: GPCR, family 2, vasoactive intestinal peptide receptor (family) [77-436]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [22-117]
- IPR050332: G-protein coupled receptor 2 (family) [10-424]
- IPR017981: GPCR, family 2-like, 7TM (domain) [127-380]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0008589 (regulation of smoothened signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Probable pectinesterase/pectinesterase inhibitor 34 [Includes: Pectinesterase inhibitor 34 (Pectin methylesterase inhibitor 34); Pectinesterase 34 (PE 34) (EC 3.1.1.11) (Pectin methylesterase 34) (AtPME34)] (Q9M3B0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MGYERLGPSGATGSVTTSTTTAPILNQVSTSEQPENNNRRSKKKLVVSSIVLAISLILAAAIFAGVRSRLKLNQSVPGLARKPSQAISKACELTRFPELCVDSLMDFPGSLAASSSKDLIHVTVNMTLHHFSHALYSSASLSFVDMPPRARSAYDSCVELLDDSVDALSRALSSVVSSSAKPQDVTTWLSAALTNHDTCTEGFDGVDDGGVKDHMTAALQNLSELVSNCLAIFSASHDGDDFAGVPIQNRRLLGVEEREEKFPRWMRPKEREILEMPVSQIQADIIVSKDGNGTCKTISEAIKKAPQNSTRRIIIYVKAGRYEENNLKVGRKKINLMFVGDGKGKTVISGGKSIFDNITTFHTASFAATGAGFIARDITFENWAGPAKHQAVALRIGADHAVIYRCNIIGYQDTLYVHSNRQFFRECDIYGTVDFIFGNAAVVLQNCSIYARKPMDFQKNTITAQNRKDPNQNTGISIHASRVLAASDLQATNGSTQTYLGRPWKLFSRTVYMMSYIGGHVHTRGWLEWNTTFALDTLYYGEYLNSGPGSGLGQRVSWPGYRVINSTAEANRFTVAEFIYGSSWLPSTGVSFLAGLSI
InterPro domains: - IPR035513: Invertase/pectin methylesterase inhibitor domain superfamily (homologous_superfamily) [84-235]
- IPR006501: Pectinesterase inhibitor domain (domain) [70-234]
- IPR011050: Pectin lyase fold/virulence factor (homologous_superfamily) [280-595]
- IPR033131: Pectinesterase, Asp active site (active_site) [429-438]
- IPR012334: Pectin lyase fold (homologous_superfamily) [278-596]
- IPR000070: Pectinesterase, catalytic (domain) [284-581]
Interaction partners: - Serine carboxypeptidase-like 41
- Probable pectate lyase 20
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: COP9 signalosome complex subunit 1 (CSN complex subunit 1) (Q5BD89)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex seems to link protein degradation to sexual development. Required for fruit body formation.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Sequence: MEPMLPEAGEAALLSSYAPQASGSMGVDPDPITGLVSTSAAPLVRVEEAPKFELESYIANYTGRTRFNRLYLIGTCSSYLAVDALKAAIAEAKSGKDVARYLRAVQALADVAPNEPEATIDSDWVERSQKVVKAETDRLEHELRGYKNNLIKESIRMGNEELGQHYHRIGDLTSAFKAYSRMRDFCTTPSHIASMLFKIINVAIERGDWLNVQSNVHRLRSQGGKPEEQAKHQPKISAAMGLSQLHSGSYLEAANSFIATDPSLGDTFNEVLTSNDVAVYGGLCALASMDRNELQRRVLDNSSFRNFLELEPHIRRAISFFCNSKFRPCLEILEAYRADYLLDIHLQRHVQVLYNRIRTKSIQQYLIPFNRVSLESMAKIFVLGNPTSQSSQSDSKSAFVQELISLIQDGTLDARIDLEKHVLVSTQGDKRIEVQEAVLDSLDNYVREAHLRLLRSNIIRAGLEVRPLGEDRRTKLEERGKKGHSAIGNLLRATGMKQ
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [343-432]
- IPR000717: Proteasome component (PCI) domain (domain) [249-442]
- IPR045135: 26S proteasome regulatory subunit Rpn7, N-terminal (domain) [121-296]
- IPR019585: 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 (family) [50-466]
Interaction partners: - COP9 signalosome complex subunit 2
- COP9 signalosome complex subunit 3
- COP9 signalosome complex subunit 7
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 4
- Ubiquitin-like domain-containing protein
- Uncharacterized protein
- COP9 signalosome complex subunit 8
- RING-box protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007163 (establishment or maintenance of cell polarity), GO:0030010 (establishment of cell polarity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0008180 (COP9 signalosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Response regulator EraR (Q9I2C7)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
Sequence: MKVLLVDDHFVVREGLAALLRGLLPDVEVNEAGDGEEALQAVQREIPSLVIVDLGLPGISGLELTRRLRQRLPQLRVLFFSLHDELALVRQALDAGARGYVTKRAAPTVLLEAIRRVLAGQLYLEQPLATRLACQSWEEQGGAALRGLTRREFEIFRLLARGLALREVAEHLGVSAKTVSNHVSLLKQKLQVSTQAELVHRAIDSGVLRLGLPLPLAEEARGSLG
InterPro domains: - IPR000792: Transcription regulator LuxR, C-terminal (domain) [141-206]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [1-118]
- IPR039420: Transcriptional regulatory protein WalR-like (family) [2-208]
- IPR011006: CheY-like superfamily (homologous_superfamily) [1-129]
- IPR016032: Signal transduction response regulator, C-terminal effector (homologous_superfamily) [142-208]
Interaction partners: - histidine kinase
- histidine kinase
- Quinoprotein ethanol dehydrogenase
- histidine kinase
- Oxygen sensor histidine kinase NreB
- Uncharacterized protein
- Probable lipoprotein
- Cytochrome c550
- Probable major facilitator superfamily
- PqqA peptide cyclase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0000160 (phosphorelay signal transduction system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Delta(14)-sterol reductase TM7SF2 (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (Sterol C14-reductase) (Transmembrane 7 superfamily member 2) (E9PLL1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|RuleBase:RU369120}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369120}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Microsome membrane {ECO:0000256|RuleBase:RU369120}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU369120}.
Sequence: MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGS
InterPro domains: - IPR001171: Sterol biosynthesis ERG24/DHCR-like (family) [56-206]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008202 (steroid metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0016126 (sterol biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process), GO:0008203 (cholesterol metabolic process), GO:0006695 (cholesterol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)