Protein: Cytochrome P450 307a1 (EC 1.14.-.-) (CYPCCCVIIA1) (Protein spook) (Q9VRM7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for correct development of the embryonic midline glial cells which are necessary for the formation of distinct segmental commissures.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
Sequence: MLAALIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLVPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSSSPIVPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVLTPREKIGPL
InterPro domains: - IPR001128: Cytochrome P450 (family) [56-525]
- IPR002401: Cytochrome P450, E-class, group I (family) [85-508]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [41-537]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [478-487]
Interaction partners: - Cholesterol 7-desaturase nvd
- Cytochrome P450 315a1, mitochondrial
- Cytochrome P450 306a1
- Spookier
- Short-chain dehydrogenase/reductase)
- Halo
- Cytochrome P450 302a1, mitochondrial
- Scavenger receptor class C, type II, isoform A
- Ecdysone receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0008395 (steroid hydroxylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0042303 (molting cycle), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009791 (post-embryonic development), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0007591 (molting cycle, chitin-based cuticle), GO:0002165 (instar larval or pupal development), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0045455 (ecdysteroid metabolic process), GO:0006066 (alcohol metabolic process), GO:0044249 (cellular biosynthetic process), GO:0010817 (regulation of hormone levels), GO:0042446 (hormone biosynthetic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008205 (ecdysone metabolic process), GO:0008202 (steroid metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0042181 (ketone biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0045456 (ecdysteroid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006697 (ecdysone biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0016126 (sterol biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)