Protein: Bud site selection protein 14 (P27637)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Important for bud site selection. Seems to be a regulatory subunit of the BUD14-GLC7 type-I phosphatase complex. The BUD14-GLC7 complex is necessary to regulate microtubule dynamics at the cortex and may function as a specific activator of the dynein complex.
Sequence: MSNKEEHVDETSASGVKEVSSIAARHDNGYAPSLITSTSGMDSFQSHALLNDPTLIEDYSDIINNRPTSGSKLTLGNEDSESMGGSVVVTPTSNKSSPFNSKLNILSNAAEKGHDVLRNRDDDKELEEENVEKHMHSNSKRDQRHYKENSSELPDSYDYSDSEFEDNLERRLQEIETDSVDSADKDEVHFSVNNTMNPDVDDFSDGLKYAISEDEDEEENYSDDDDFDRKFQDSGFQGEKDDLEEENDDYQPLSPPRELDPDKLYALYAFNGHDSSHCQLGQDEPCILLNDQDAYWWLVKRITDGKIGFAPAEILETFPERLARLNCWKNENMSSQSVASSDSKDDSISSGNKNQSDAESIIPTPALNGYGKGNKSVSFNDVVGYADRFIDDAIEDTSLDSNDDGGEGNGQSYDDDVDNDKETKVTHRDEYTEAKLNFGKFQDDDTSDVVSDVSFSTSLNTPLNVKKVRRQDNKNESEPKTSSSKDREDDYNANRYVGQEKSEPVDSDYDTDLKKVFEAPRMPFANGMAKSDSQNSLSTIGEFSPSSSEWTNESPSTPIVEESSSIPSSRAIKDISQYIHAKSKIEETTNVENTEGQIQASLGSSGGMANQTDAEQPKEELEKHHSTPEEEKQSTLSLHSSSEEDFYMDEQRAVSSASINSSLSGSRALSNTNMSDPASKPNSLVQHLYAPVFDRMDVLMKQLDEIIRK
InterPro domains: - IPR053039: Cell Polarity and Bud Site Selection Regulator (family) [74-487]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [249-340]
- IPR001452: SH3 domain (domain) [259-320]
Interaction partners: - Kelch repeat-containing protein 1
- Kelch repeat-containing protein 2
- Serine/threonine-protein phosphatase PP1-2
- BNI1-related protein 1
- Protein BNI1
- GTPase-activating protein BEM2/IPL2
- Kinesin-related protein SMY1
- Bud site selection protein 6
- RNA end formation protein 2
- Serine/threonine-protein kinase KIN2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0007163 (establishment or maintenance of cell polarity), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0033036 (macromolecule localization), GO:0048523 (negative regulation of cellular process), GO:0033036 (macromolecule localization), GO:0030010 (establishment of cell polarity), GO:1903047 (mitotic cell cycle process), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0061245 (establishment or maintenance of bipolar cell polarity), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0030952 (establishment or maintenance of cytoskeleton polarity), GO:1901700 (response to oxygen-containing compound), GO:0030036 (actin cytoskeleton organization), GO:0010033 (response to organic substance), GO:0000278 (mitotic cell cycle), GO:0034599 (cellular response to oxidative stress), GO:0044772 (mitotic cell cycle phase transition), GO:0022604 (regulation of cell morphogenesis), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0030866 (cortical actin cytoskeleton organization), GO:0071310 (cellular response to organic substance), GO:0062197 (cellular response to chemical stress), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0007010 (cytoskeleton organization), GO:0033365 (protein localization to organelle), GO:0034614 (cellular response to reactive oxygen species), GO:1990778 (protein localization to cell periphery), GO:0072697 (protein localization to cell cortex), GO:0044380 (protein localization to cytoskeleton), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1990752 (microtubule end), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0099080 (supramolecular complex), GO:0035371 (microtubule plus-end), GO:0005881 (cytoplasmic microtubule), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0005935 (cellular bud neck), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0005856 (cytoskeleton), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)