wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Ubiquitin (C0H4U7)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MIKKVHICLFIIFFYVIFLIHICKGIRLQNYKNERINNRHMLNTIRNNVSIYQNKHISNNNTKENKCNIMINYYDKSNIFCKSFLLSMEEKDNIKNIKKKIEEIYGIPLTLQEILYDNKKLENNITIQNIIKDKQIKILNLRLITILPHLFLQKDDDNNTNKRNDVSSSSSSSSLYNNEYIKSNKRITYLKNKLTYYGYLTLLNEYKKLSHILENKKYILKNDDILESFKSFDQEFEKTLKNNNINLHKIKKEINKLKHIDKKKLLLRLEVDYPLMSNNLTKRIKQLFQYYYMGDITTIIKFSIFFYILYKYADYPNHIKKFFLYLSILFLISPFKPFYKFSHFLFFSVPNNILFSGFTNILSASYQQILMCQ
InterPro domains: - IPR000626: Ubiquitin-like domain (domain) [69-135]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [82-151]
Interaction partners: - NEDD8-activating enzyme E1 catalytic subunit
- Ubiquitin carboxyl-terminal hydrolase UCHL3
- NEDD8-conjugating enzyme UBC12, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0020011 (apicoplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Aspartic proteinase yapsin-1 (EC 3.4.23.-) (O59774)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Cleaves at paired basic residues.
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Secreted, cell wall.
Sequence: MRIWILIFFSFIKLVSSLQYTGNGVLALDFVAKTFPNQENQLEKRDYTYSPSGITSFPLDLQSYTYYTTTLSIGRPSISYTVAIDLDMPYTWLTYYNVMAFNPAYLGIVNSGTQWSTDELRYFLCKKESDSCYFGNASSSFHFVTSPSTFFIRYDDNITVAGINVQDSLSYSHYQALPDFQFGITLKEYVPSSMLPYKGVLGLAASTEINSIDYSDSISSFSPPTFLEQLVKEDILAYPAFSMYLDNQGNGSLLLGAVDTSKYQGQFVALKQTKLTHYAVSIYSVQFLNSTFFSNYSIITDAYFQTRETYIYLPAELAYSVMDNAGAYLSEGYFALNCDEIDLEAALIFQFGCNSTIKVPISLLVIGQVSNICLLGIRPSTDSEIVLGLLFFRNAYTFYHQSQKMIAIGQAFYNATSNLSAIVDQHIPGALTCSQYPTSVASTQLVQTSHFTSTSLSAVNISESVVYSYTSSSSMPSSAIPSFNISLISQNAVANAGNSFSPLSAMVIMMMSAVFLGLGII
InterPro domains: - IPR033121: Peptidase family A1 domain (domain) [67-410]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [52-422]
- IPR001461: Aspartic peptidase A1 (family) [46-408]
Interaction partners: - Uncharacterized membrane protein C61.05
- Dibasic-processing endoprotease
- Protein MIX23
- Bifunctional purine biosynthesis protein ade10
- Vacuolar protein sorting/targeting protein 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0070001 (aspartic-type peptidase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0016043 (cellular component organization), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0031505 (fungal-type cell wall organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009897 (external side of plasma membrane), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009277 (fungal-type cell wall)
Protein: DDHD domain containing 2 (E9PK57)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MVVPGVEFEPMLIPHHKGRKRMHLELREGLTRMSMDLKNNLLGSLRMAWKSFTRAPYPALQASETPEETEAEPESTSEKPSDVNTEETSVAVKEEVLPINVGMLNGGQRIDYVLQEKPIESFNEYLFALQSHLCYWESEDTVLLVLKEIYQTQGIFLDQPLQ
InterPro domains: - IPR004177: DDHD domain (domain) [1-151]
- IPR058055: PA-PLA1 (family) [7-153]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0007030 (Golgi organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Chitin elicitor-binding protein (CEBiP) (OsCEBiP) (Lysin motif-containing protein 1) (Os-LYP1) (Q8H8C7)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Chitin elicitor-binding protein involved in the perception and transduction of chitin oligosaccharide elicitor signal for defense responses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16829581}; Single-pass membrane protein {ECO:0000269|PubMed:16829581}.
Sequence: MASLTAALATPAAAALLLLVLLAAPASAANFTCAVASGTTCKSAILYTSPNATTYGNLVARFNTTTLPDLLGANGLPDGTLSSAPVAANSTVKIPFRCRCNGDVGQSDRLPIYVVQPQDGLDAIARNVFNAFVTYQEIAAANNIPDPNKINVSQTLWIPLPCSCDKEEGSNVMHLAYSVGKGENTSAIAAKYGVTESTLLTRNKIDDPTKLQMGQILDVPLPVCRSSISDTSADHNLMLLPDGTYGFTAGNCIRCSCSSTTYQLNCTAVQNKGCPSVPLCNGTLKLGETNGTGCGSTTCAYSGYSNSSSLIIQTSLATNQTTACQRGGSGRSQFARSMWSMSVISFHMVLIIICFL
InterPro domains: - IPR036779: LysM domain superfamily (homologous_superfamily) [111-231]
- IPR018392: LysM domain (domain) [111-220]
Interaction partners: - Chitin elicitor receptor kinase 1
- Receptor-like cytoplasmic kinase 185
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008061 (chitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0006955 (immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0055044 (symplast), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005911 (cell-cell junction)
Protein: Carboxypeptidase D (EC 3.4.17.22) (CPD-2) (Metallocarboxypeptidase D) (P83852)
Organism: Lophonetta specularioides (Crested duck) (Anas specularioides)
Function: Not known
Sequence: QAVQPVDFRHHHFSDMEIFLRRYANEYPSITRLYSVGKSVELRELYVMEISDNPGIHEAGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVQSTRIHIMPSMNPDGYEKSQEGDRGGTVGRNNSNNYDLNRNFPDQFFQVTDPPQPETLAVMSWLKTYPFVLSANLHGGSLVVNYPFDDDEQGIAIYSKSPDDAVFQQLALSYSKENKKMYQGSPCKDLYPTEYFPHGITNGAQWYNVPGGMQDWNYLNTNCFEVTIELGCVKYPKAEELPKYWEQNRRSLLQFIKQVHRGIWGFVLDATDGRGILNATISVADINHPVTTYKDGDYWRLLVQGTYKVTASARGYDPVTKTVEVDSKGGVQVNFTLSRT
InterPro domains: - IPR057247: Zinc carboxypeptidases, zinc-binding region 2 (binding_site) [178-188]
- IPR008969: Carboxypeptidase-like, regulatory domain superfamily (homologous_superfamily) [302-378]
- IPR034224: Carboxypeptidase D, carboxypeptidase-like domain 2 (domain) [3-298]
- IPR000834: Peptidase M14, carboxypeptidase A (domain) [9-299]
- IPR057246: Zinc carboxypeptidases, zinc-binding region 1 (binding_site) [62-84]
- IPR050753: Peptidase M14 domain-containing protein (family) [4-378]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0043169 (cation binding), GO:0008233 (peptidase activity), GO:0046872 (metal ion binding), GO:0008237 (metallopeptidase activity), GO:0008238 (exopeptidase activity), GO:0046914 (transition metal ion binding), GO:0004180 (carboxypeptidase activity), GO:0008235 (metalloexopeptidase activity), GO:0004181 (metallocarboxypeptidase activity), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Probable zinc metallopeptidase EGY3, chloroplastic (EC 3.4.24.-) (Protein ETHYLENE-DEPENDENT GRAVITROPISM-DEFICIENT AND YELLOW-GREEN 3) (AtEGY3) (Q9LMU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable membrane-associated metalloprotease that may be involved in chloroplast development.
Subcellular location: Plastid, chloroplast membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MASLFVSTPSSSLTLKSCHSLHLRRFDRAEFSNFGKASVNQTTRSRHSLRCSAEDDRVREPVNEAPSPVALAEEQKEDHDNNNAPPSPESSEEEEEKKSKQQEMDWKTDEEFKKFMGNPSIEAAIKLEKTRTDRKLKELNKESNSENPIIGIYNSLARDSLTKEKERLEKAEETFKALDLNKLKSCFGFDTFFATDVRRFGDGGIFIGNLRKPIDEVTPKLEAKLSEAAGRDVVVWFMEERSNEITKQVCMVQPKAEIDLQFESTRLSTPWGYVSAIALCVTTFGTIALMSGFFLKPDATFDDYIANVVPLFGGFLSILGVSEIATRVTAARHGVKLSPSFLVPSNWTGCLGVMNNYESLLPNKKALFDIPVARTASAYLTSLLLAAAAFISDGSFNGGDNALYIRPQFFDNNPLLSFVQFVVGPYADDLGNVLPNAVEGVGVPVDPLAFAGLLGMVVTSLNLLPCGRLEGGRIAQAMFGRSTAAILSFTTSLLLGIGGLSGSVLCLAWGLFATFFRGGEETPAKDEITPVGDDRFAWGIVLGLICFLTLFPNSGGTFSTSFFNGPFFRGDDF
InterPro domains: - IPR044838: Probable metalloprotease EGY1-like (family) [13-562]
Interaction partners: - ATP-dependent zinc metalloprotease FTSH 6, chloroplastic
- Protein LIFEGUARD 4
- carnosine N-methyltransferase
- Membrane-bound transcription factor site-2 protease homolog
- Probable acyl-activating enzyme 8
- DNA ligase
- Zinc finger A20 and AN1 domain-containing stress-associated protein 10
- Putative protease Do-like 14
- ATP-dependent zinc metalloprotease FTSH 10, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0016020 (membrane), GO:0006091 (generation of precursor metabolites and energy), GO:0015979 (photosynthesis), GO:0044085 (cellular component biogenesis), GO:0019684 (photosynthesis, light reaction), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0010207 (photosystem II assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0043227 (membrane-bounded organelle), GO:0009507 (chloroplast), GO:0042651 (thylakoid membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0031968 (organelle outer membrane), GO:0009579 (thylakoid), GO:0055035 (plastid thylakoid membrane), GO:0009535 (chloroplast thylakoid membrane), GO:0009534 (chloroplast thylakoid)
Protein: Probable solute-binding protein (Q9I2T3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
Sequence: MRRLSFLILGLAVSLPSFAAITQSHGYAQFGTLKYPANFQHFDWTNPDAPKGGTLRLMASGSFDTLNPYTLKGTSPIGTGDFLQYGVNELNEPLMVGTGLYDPSGDEPASSYGLIAKSVEYAENRSWVVFNLRPEARFHDGRPITASDVAFSYRTLVKQGHPMYRTYLQEVKRVDILTPHRVRFVLRRSGNPLLILRLGELPVLPQHYWKDRDFRATTFTAPLGSGPYRIVEVDPGRRLVFERVKGWWGEKLPVNRGKYNFDRVVVDFYRDNGVAFEAFKAGEFDFYIEHQAKNWLNNYRFPAVLRGDVIRTEIPHQIPSQTQALFMNTRRAVFKERALRQALGEMFDFEWTNRALFSNSYLRSRSYYPNSEFAASGVPEGQEWLYLSPYRKQLPAQLFKQPFSLPTTEGRGIPRETLRHALGLLADAGWKLSGDRLLNKKGEPLRFEILLVNPSLERILQPYRENLASIGIDARLRTVDRAQYKQRLDQFDYDMILMTLPQTLSPGLEQWQYFHSSQVKVKGSKNYAGIANPVVDAMLNRLLGAHSRDEQVAAARALDRTLLWQYYSIPNWYLNSHRLAYRNRFAFVATPPYTLGLRAWWQKNLETSR
InterPro domains: - IPR039424: Solute-binding protein family 5 (family) [2-592]
- IPR000914: Solute-binding protein family 5 domain (domain) [114-507]
- IPR030678: Peptide/nickel binding protein, MppA-type (family) [1-606]
Interaction partners: - Probable binding protein component of ABC transporter
- Inner membrane ABC transporter permease protein YejB
- Probable permease of ABC transporter
- ABC-type dipeptide transporter
- Probable binding protein component of ABC transporter
- Inner membrane ABC transporter permease protein YejB
- Probable permease of ABC transporter
- Enoyl-[acyl-carrier-protein] reductase FabI
- ABC-type dipeptide transporter
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0140359 (ABC-type transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:1904680 (peptide transmembrane transporter activity), GO:0035673 (oligopeptide transmembrane transporter activity), GO:0071916 (dipeptide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015833 (peptide transport), GO:0042886 (amide transport), GO:0006857 (oligopeptide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0031975 (envelope), GO:0098796 (membrane protein complex), GO:0042597 (periplasmic space), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:0030313 (cell envelope), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0030288 (outer membrane-bounded periplasmic space), GO:0098533 (ATPase dependent transmembrane transport complex), GO:0043190 (ATP-binding cassette (ABC) transporter complex)
Protein: Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) (Omega-atracotoxin-Hv2a) (AcTx-Hv2) (Omega-AcTx-Hv2a) (P82852)
Organism: Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)
Function: Potent inhibitor of insect (bee brain), but not mammalian (rat trigeminal neurons), voltage-gated calcium channels (Cav). As for omega-AcTx-Hv1a, the phenotypic effect of injection of this toxin into lone star ticks (Amblyomma americanum) is curling of all eight legs into closed loops, followed by death.
Subcellular location: Secreted {ECO:0000269|PubMed:11522785}.
Sequence: LLACLFGNGRCSSNRDCCELTPVCKRGSCVSSGPGLVGGILGGIL
InterPro domains: - IPR013139: Omega-atracotoxin, conserved site-2 (conserved_site) [17-24]
- IPR012628: Magi 5 toxic peptide (family) [3-32]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044359 (modulation of molecular function in another organism), GO:0044561 (modulation of ion channel activity in another organism)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Protein atp11, mitochondrial (P87127)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for the assembly of the mitochondrial F1-F0 complex. May interact with the alpha and/or beta subunits of F1-ATPase (By similarity).
Subcellular location: Mitochondrion {ECO:0000250}.
Sequence: MLPIWKLPVNHLLCHSFKSIPRTSAYAVRFAHHTSNNDDLEVKKNTVYERYERKLKSKAEELHMPVTNLLKKGQTKEREHVIPKKSFSAKKSLVGQNAKKSDLSGLNRYIDVEKIKELPTSTIEKLWRARNIGDDILSACIPKEIYEKMLSRARMYPYFVLPLPRGDKGIESHFLQWNFPNKNEAHLLVTSLLEYKLKGSYAAPHTIMLHFADLLNLKGITLMRCQFEPKKLSANDVQLLVLAIQKFYNASENTPLGKERLALLAAFSKGADFDLHKVATHMDMLE
InterPro domains: - IPR010591: ATP11 (family) [33-285]
Interaction partners: - Protein atp12
- Cytochrome B pre-mRNA-processing protein 6
- Mitochondrial zinc maintenance protein 1
- ATP synthase subunit beta, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0070071 (proton-transporting two-sector ATPase complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94) (Q13241)
Organism: Homo sapiens (Human)
Function: Immune receptor involved in self-nonself discrimination. In complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia and non-classical MHC class Ib molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self. Primarily functions as a ligand binding subunit as it lacks the capacity to signal.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:9485206}; Single-pass type II membrane protein {ECO:0000255}.
Sequence: MAVFKTTLWRLISGTLGIICLSLMSTLGILLKNSFTKLSIEPAFTPGPNIELQKDSDCCSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQNTDELDFMSSSQQFYWIGLSYSEEHTAWLWENGSALSQYLFPSFETFNTKNCIAYNPNGNALDESCEDKNRYICKQQLI
InterPro domains: - IPR050919: NKG2/CD94 Natural Killer Receptors (family) [4-178]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [57-179]
- IPR016187: C-type lectin fold (homologous_superfamily) [14-177]
- IPR001304: C-type lectin-like (domain) [61-176]
- IPR033992: Natural killer cell receptor-like, C-type lectin-like domain (domain) [61-176]
Interaction partners: - HLA class I histocompatibility antigen, alpha chain E
- TYRO protein tyrosine kinase-binding protein
- NKG2-A/NKG2-B type II integral membrane protein
- NKG2-C type II integral membrane protein
- HLA class I histocompatibility antigen, C alpha chain
- HLA class I histocompatibility antigen, alpha chain G
- NKG2-E type II integral membrane protein
- Killer cell immunoglobulin-like receptor 2DL3
- Killer cell immunoglobulin-like receptor 2DL1
- Killer cell immunoglobulin-like receptor 3DL1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ectodysplasin A receptor (Tumor necrosis factor receptor superfamily member EDAR precursor) (A0A0R4IGE7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MGHKGGRTPSFLLHFLLVSSMSTVSAEYSSCGENEFYNHTTSSCQPCPQCQAGQEPYMNCGYGTKDDDYSCVSCPAGKFSKGKYEICRRHKDCDALYRATVLTPGTSDSDAECGHCLPGYYIQENRPQNIYGMVCHSCQNAPRNIKECMRSTPPASGRAPSVSSSSTTIFPQPEKDPTGQGHLATALIIAMSTIFIMAIAIVMIIMFYILKSKPSGPVCCSGQLIKAVEAQTNMQEEKKEAQENVVIFQEKDEFDKLKPSSPKTAKSENDASSENEQLLSRSIDSDEEAAQDKQGAADLCLLSLVHLTRDKSCTTNTINNNNNNHCSRATGIHSRRKKILDLYTKACSVAEGLSPTELPFDCLERSSRMLSATYSTDKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPDLLARLLQIERLDAVETLCCDILSGTQNCTNPPLSSRCASV
InterPro domains: - IPR034052: Tumor necrosis factor receptor EDAR, N-terminal (domain) [13-148]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [354-450]
- IPR056762: Tumor necrosis factor receptor superfamily member EDAR, death domain (domain) [368-441]
- IPR047526: Tumor necrosis factor receptor superfamily member 19/27/EDAR (family) [10-445]
Interaction partners: - Ectodysplasin A
- Ectodysplasin-A receptor-associated adapter protein
- Paired box protein Pax-9
- Sodium/potassium/calcium exchanger 5
- Lymphoid enhancer-binding factor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0008544 (epidermis development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)