Protein: Protein Mis18-alpha (Q9CZJ6)
Organism: Mus musculus (Mouse)
Function: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9NYP9}. Chromosome {ECO:0000250|UniProtKB:Q9NYP9}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9NYP9}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. {ECO:0000250|UniProtKB:Q9NYP9}.
Sequence: MSSESPLLEKRLSEDSSRYLRLQKWANMSSADALGLEKERPEEKAAAAENPLVFLCARCRRPLGDSLTWVASQEDTNCILLRSVSCNVSVDKEPKLSKCRDEDGCILEALYCTGCSLSLGYVYRCTPKNLDYKRDLFCLSVEAVESYTLGSSEKQIVSEDKELFNLESRVEIEKSIKQMEEVLTALQKKLREVESKLSLASRGS
InterPro domains: - IPR004910: Yippee/Mis18/Cereblon (domain) [52-157]
- IPR034752: Mis18 domain (domain) [51-149]
Interaction partners: - Mis18-binding protein 1
- Protein Mis18-beta
- Centromere protein K
- Histone H3-like centromeric protein A
- Centromere protein W
- Centromere protein Q
- Holliday junction recognition protein
- Centromere protein I
- Centromere protein R
- Borealin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010941 (regulation of cell death), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010369 (chromocenter), GO:0005634 (nucleus)