Protein: Protein claret segregational (EC 3.6.4.-) (Kinesin-14) (P20480)
Organism: Drosophila melanogaster (Fruit fly)
Function: Minus-end-directed microtubule-based motor protein. Has ATPase activity. Required for normal chromosomal segregation in meiosis in females, and in early mitotic divisions of the embryo.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Sequence: MESRLPKPSGLKKPQMPIKTVLPTDRIRAGLGGGAAGAGAFNVNANQTYCGNLLPPLSRDLNNLPQVLERRGGGARAASPEPMKLGHRAKLRRSRSACDINELRGNKRTAAAPSLPSIPSKVSRLGGALTVSSQRLVRPAAPSSITATAVKRPPVTRPAPRAAGGAAAKKPAGTGAAASSGAAAAAPKRIAPYDFKARFHDLLEKHKVLKTKYEKQTEDMGELESMPQQLEETQNKLIETESSLKNTQSDNECLQRQVKQHTAKIETITSTLGRTKEELSELQAIHEKVKTEHAALSTEVVHLRQRTEELLRCNEQQAAELETCKEQLFQSNMERKELHNTVMDLRGNIRVFCRIRPPLESEENRMCCTWTYHDESTVELQSIDAQAKSKMGQQIFSFDQVFHPLSSQSDIFEMVSPLIQSALDGYNICIFAYGQTGSGKTYTMDGVPESVGVIPRTVDLLFDSIRGYRNLGWEYEIKATFLEIYNEVLYDLLSNEQKDMEIRMAKNNKNDIYVSNITEETVLDPNHLRHLMHTAKMNRATASTAGNERSSRSHAVTKLELIGRHAEKQEISVGSINLVDLAGSESPKTSTRMTETKNINRSLSELTNVILALLQKQDHIPYRNSKLTHLLMPSLGGNSKTLMFINVSPFQDCFQESVKSLRFAASVNSCKMTKAKRNRYLNNSVANSSTQSNNSGSFDK
InterPro domains: - IPR027640: Kinesin-like protein (family) [204-679]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [574-585]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [305-668]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [289-673]
- IPR001752: Kinesin motor domain (domain) [346-678]
Interaction partners: - Kinesin-like protein Klp61F
- Protein mini spindles
- RT07324p
- Inner centromere protein, isoform A
- Kinesin-like protein at 67A, isoform A
- Kinesin-like protein
- Mitotic spindle assembly checkpoint protein MAD2A
- Guanylate kinase-associated protein mars
- Tubulin gamma-2 chain
- Transforming acidic coiled-coil protein, isoform K
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0003777 (microtubule motor activity), GO:0005515 (protein binding), GO:0008574 (plus-end-directed microtubule motor activity), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:1903046 (meiotic cell cycle process), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0051640 (organelle localization), GO:0016344 (meiotic chromosome movement towards spindle pole), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0051305 (chromosome movement towards spindle pole), GO:0007051 (spindle organization), GO:0051649 (establishment of localization in cell), GO:0045132 (meiotic chromosome segregation), GO:0000226 (microtubule cytoskeleton organization), GO:0007018 (microtubule-based movement), GO:0007059 (chromosome segregation), GO:0140013 (meiotic nuclear division), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0050000 (chromosome localization), GO:0051231 (spindle elongation), GO:0016043 (cellular component organization), GO:0000212 (meiotic spindle organization), GO:0007143 (female meiotic nuclear division), GO:0007056 (spindle assembly involved in female meiosis), GO:0051647 (nucleus localization), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0098813 (nuclear chromosome segregation), GO:0010970 (transport along microtubule), GO:0140014 (mitotic nuclear division), GO:0007052 (mitotic spindle organization), GO:0007127 (meiosis I), GO:0051303 (establishment of chromosome localization), GO:0022607 (cellular component assembly), GO:0090306 (meiotic spindle assembly), GO:0051225 (spindle assembly), GO:0007292 (female gamete generation), GO:0007097 (nuclear migration), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0070925 (organelle assembly), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0007010 (cytoskeleton organization), GO:0000819 (sister chromatid segregation), GO:0090307 (mitotic spindle assembly), GO:0000280 (nuclear division), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1990752 (microtubule end), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035371 (microtubule plus-end), GO:0099081 (supramolecular polymer), GO:0005881 (cytoplasmic microtubule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005819 (spindle), GO:0005874 (microtubule), GO:0005876 (spindle microtubule), GO:0015630 (microtubule cytoskeleton)