Protein: Sialic acid-binding Ig-like lectin 9 (Siglec-9) (CDw329) (Protein FOAP-9) (CD antigen CD329) (Q9Y336)
Organism: Homo sapiens (Human)
Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGVVGGAGATALVFLSFCVIFVVVRSCRKKSARPAAGVGDTGIEDANAVRGSASQGPLTEPWAEDSPPDQPPPASARSSVGEGELQYASLSFQMVKPWDSRGQEATDTEYSEIKIHR
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [26-137]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [21-338]
- IPR007110: Immunoglobulin-like domain (domain) [20-336]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [15-343]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [160-224]
- IPR051036: Sialic acid-binding Ig-like lectin (family) [2-460]
- IPR003599: Immunoglobulin domain subtype (domain) [26-338]
Interaction partners: - Amine oxidase [copper-containing] 3
- Mucin-1
- Mucin-16
- Kallikrein-14
- Kallikrein-13
- Sialic acid-binding Ig-like lectin 7
- Neural cell adhesion molecule 1
- Tyrosine-protein phosphatase non-receptor type 11
- Low affinity immunoglobulin gamma Fc region receptor III-A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048857 (neural nucleus development), GO:0030901 (midbrain development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021762 (substantia nigra development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0009897 (external side of plasma membrane), GO:0005794 (Golgi apparatus), GO:0042579 (microbody), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0070820 (tertiary granule), GO:0005777 (peroxisome), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0070821 (tertiary granule membrane), GO:0035579 (specific granule membrane)