Protein: Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) (Q9NUP9)
Organism: Homo sapiens (Human)
Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12967566, ECO:0000269|PubMed:21849460}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Postsynaptic density membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000250}.
Sequence: MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [87-197]
- IPR036892: L27 domain superfamily (homologous_superfamily) [9-63]
- IPR051109: Membrane-associated multiprotein complex regulator (family) [7-196]
- IPR014775: L27 domain, C-terminal (domain) [15-67]
- IPR001478: PDZ domain (domain) [93-175]
- IPR004172: L27 domain (domain) [10-68]
- IPR017365: Protein lin-7 (family) [1-195]
Interaction partners: - Peripheral plasma membrane protein CASK
- Amyloid-beta A4 precursor protein-binding family A member 1
- Disks large homolog 4
- MAGUK p55 subfamily member 7
- Protein PALS1
- Disks large homolog 1
- MAGUK p55 subfamily member 3
- MAGUK p55 subfamily member 2
- Protein PALS2
- Protein lin-7 homolog B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0140352 (export from cell), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)