Protein: Unconventional myosin-VI (A0A8M9PH95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, filopodium. Cell projection, microvillus. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Nucleus
Sequence: MDDGKPVWAPHPTDGFQLGRIIDISADSLTIEPLNQRGKNFQAPVDQVFPAEDDVNKHVEDNCSLMYLNEATLLNNVRVRYSKDKIYTFVANILIAVNPYCEIPKLYSPETIKQYQGRSLGTLPPHVYAIADKAYRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYLTTSYGTGQDIDERIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKNAVVGGFVSHYLLEKSRICTQGQEERNYHIFYRLCAGAPEDIREKFHLSSPDCFRYLCRGCTRYFSTKDSDKLIPQNRKSPELLKAGPLKDPLLDDHADFNRMSVAMKKIGLDDTEKLNLFRVVAGVLHLGNIDFEEAGSTSGGCVLKKTCGQSLQFCAELLGLDEEDLRVSLTSRVMLTTAGGTKGTVIKVPLKVEQASSARDALAKAIYSRLFDHVVTRINQCFPFDSSAHFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLVESKVVGILDILDEENRLPQPSDQHFTETVHSKHKDHFRLTVPRKSKLQVHRNVRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLACLVSESKDKFIGELFENSNHSKDTKQKAGKLSFISVGNKFKTQLNILLEKLHSTGSSFVRCVKPNLKMVGHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRAPFHELYNMYKQYMPAKLTRLDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNKWLICSRWKKVQWCALSVIKLKNKMLYRAQACVQMQKTVRMWLCRRKHKPRIDGLVKAQNLKKRMEKLNEVVSGLKEGKQEMSKHMQDLDSSIDAHIRKIKSIVMSRMDIDHEHQALVTRSQELLSAMQKKKQEEEEMERLKRIQEEMEKERKRREEEEQKRKREEEERRQKAEMELKRKQEEEERKKREEEERKLQEEMELQLEAEREQETSRQAVLEQERRDRELALRIAQSEAELIPEETPPDAGLRSVAPPQKLKSLTMEEMAKEMSDLLARGPQVSANNAQADVKKYELSKWKYAELRDAINTSCDIELLAACREEFHRRLKVYHAWKSKNKKRNVQEEQRAPKAITDYVGIIGSQAFIAQQNPVVPAAVPRQHEIVMNRQQRFFRIPFIRPGDQYKDPQSKKKGWWYAHFDGPWIARQMELHPDKHPILLVAGKDDMEMCELSLEETGLTRKRGAEILPRQFEEIWERCGGIQYLRNAIESRQARPTYATAMLQSMLK
InterPro domains: - IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [51-703]
- IPR001609: Myosin head, motor domain-like (domain) [51-771]
- IPR036114: Class VI myosin, motor domain (domain) [71-758]
- IPR004009: Myosin, SH3 domain (domain) [2-53]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [33-833]
- IPR049016: Myosin VI, lever arm (domain) [769-912]
- IPR032412: Myosin VI, cargo binding domain (domain) [1171-1261]
- IPR008989: Myosin S1 fragment, N-terminal (homologous_superfamily) [1-50]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0009581 (detection of external stimulus), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0048839 (inner ear development), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0008544 (epidermis development), GO:0007423 (sensory organ development), GO:0060113 (inner ear receptor cell differentiation), GO:0050982 (detection of mechanical stimulus), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0007600 (sensory perception), GO:0030855 (epithelial cell differentiation), GO:0042490 (mechanoreceptor differentiation), GO:0035315 (hair cell differentiation), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0043583 (ear development), GO:0050954 (sensory perception of mechanical stimulus), GO:0042491 (inner ear auditory receptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)