Protein: Fragile X mental retardation 1, isoform CRA_e (Fragile X messenger ribonucleoprotein 1) (G3V0J0)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell projection, dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium tip {ECO:0000256|ARBA:ARBA00004495}. Cell projection, growth cone {ECO:0000256|ARBA:ARBA00004624}. Chromosome, centromere {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm, Stress granule {ECO:0000256|ARBA:ARBA00004210}. Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}. Perikaryon {ECO:0000256|ARBA:ARBA00004484}. Presynaptic cell membrane {ECO:0000256|ARBA:ARBA00034111}. Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
Sequence: MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEVEVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVVIGKNGKLIQEIVDKSGVVRVRIEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP
InterPro domains: - IPR047436: Fragile X messenger ribonucleoprotein 1, second Tudor-like Agenet domain (domain) [58-120]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [216-402]
- IPR008395: Agenet-like domain (domain) [63-117]
- IPR047438: Fragile X messenger ribonucleoprotein 1, first type I K homology domain (domain) [123-199]
- IPR022034: Fragile X messenger ribonucleoprotein 1-like, C-terminal core (domain) [397-519]
- IPR004087: K Homology domain (domain) [217-399]
- IPR032196: Fragile X messenger ribonucleoprotein 1, C-terminal region 2 (domain) [526-592]
- IPR040472: Synaptic functional regulator FMRP, KH0 domain (domain) [123-207]
- IPR040148: Fragile X messenger ribonucleoprotein 1 (family) [1-575]
- IPR047431: Fragile X messenger ribonucleoprotein 1, first Tudor-like Agenet domain (domain) [1-55]
- IPR004088: K Homology domain, type 1 (domain) [221-278]
- IPR041560: FMR1, tudor domain (domain) [4-115]
- IPR047440: Fragile X messenger ribonucleoprotein 1, second type I K homology domain (domain) [218-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0097159 (organic cyclic compound binding), GO:0030371 (translation repressor activity), GO:1901363 (heterocyclic compound binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0140693 (molecular condensate scaffold activity), GO:0042802 (identical protein binding), GO:0043021 (ribonucleoprotein complex binding), GO:0003676 (nucleic acid binding), GO:0140030 (modification-dependent protein binding), GO:0046983 (protein dimerization activity), GO:0044325 (transmembrane transporter binding), GO:0031369 (translation initiation factor binding), GO:0140666 (annealing activity), GO:0046982 (protein heterodimerization activity), GO:0140034 (methylation-dependent protein binding), GO:0043022 (ribosome binding), GO:0042803 (protein homodimerization activity), GO:0035064 (methylated histone binding), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0003727 (single-stranded RNA binding), GO:0003729 (mRNA binding), GO:0061980 (regulatory RNA binding), GO:0048027 (mRNA 5'-UTR binding), GO:0070717 (poly-purine tract binding), GO:0008187 (poly-pyrimidine tract binding), GO:1990825 (sequence-specific mRNA binding), GO:0035197 (siRNA binding), GO:0035198 (miRNA binding), GO:0003730 (mRNA 3'-UTR binding), GO:0008266 (poly(U) RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048524 (positive regulation of viral process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0044237 (cellular metabolic process), GO:0060148 (positive regulation of post-transcriptional gene silencing), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0060998 (regulation of dendritic spine development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044827 (modulation by host of viral genome replication), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0051702 (biological process involved in interaction with symbiont), GO:0044057 (regulation of system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0098908 (regulation of neuronal action potential), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051098 (regulation of binding), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:1900370 (positive regulation of post-transcriptional gene silencing by RNA), GO:0009891 (positive regulation of biosynthetic process), GO:0044087 (regulation of cellular component biogenesis), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1903900 (regulation of viral life cycle), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0042391 (regulation of membrane potential), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:1903902 (positive regulation of viral life cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0009615 (response to virus), GO:0030100 (regulation of endocytosis), GO:0098586 (cellular response to virus), GO:0031344 (regulation of cell projection organization), GO:0034250 (positive regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0051246 (regulation of protein metabolic process), GO:0031330 (negative regulation of cellular catabolic process), GO:0010628 (positive regulation of gene expression), GO:0048260 (positive regulation of receptor-mediated endocytosis), GO:0010468 (regulation of gene expression), GO:0060491 (regulation of cell projection assembly), GO:0051099 (positive regulation of binding), GO:0051851 (modulation by host of symbiont process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0051969 (regulation of transmission of nerve impulse), GO:0090304 (nucleic acid metabolic process), GO:0031644 (regulation of nervous system process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0006259 (DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2000637 (positive regulation of miRNA-mediated gene silencing), GO:1902373 (negative regulation of mRNA catabolic process), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0060966 (regulation of gene silencing by RNA), GO:0061013 (regulation of mRNA catabolic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1903312 (negative regulation of mRNA metabolic process), GO:0043484 (regulation of RNA splicing), GO:0006281 (DNA repair), GO:1902369 (negative regulation of RNA catabolic process), GO:0002092 (positive regulation of receptor internalization), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:1903311 (regulation of mRNA metabolic process), GO:0044788 (modulation by host of viral process), GO:0045727 (positive regulation of translation), GO:0060147 (regulation of post-transcriptional gene silencing), GO:0010608 (post-transcriptional regulation of gene expression), GO:0048024 (regulation of mRNA splicing, via spliceosome), GO:0051489 (regulation of filopodium assembly), GO:0002090 (regulation of receptor internalization), GO:0050684 (regulation of mRNA processing), GO:1900368 (regulation of post-transcriptional gene silencing by RNA), GO:0060964 (regulation of miRNA-mediated gene silencing), GO:0000381 (regulation of alternative mRNA splicing, via spliceosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)