Protein: Flavodoxin/ferredoxin--NADP reductase (EC 1.18.1.2) (EC 1.19.1.1) (Ferredoxin (flavodoxin):NADP(+) oxidoreductase) (Ferredoxin--NADP reductase) (FNR) (Flavodoxin--NADP reductase) (FLDR) (Methyl viologen resistance protein A) (dA1) (P28861)
Organism: Escherichia coli (strain K12)
Function: Transports electrons between flavodoxin or ferredoxin and NADPH. Reduces flavodoxin 1, flavodoxin 2 and ferredoxin, ferredoxin being the kinetically and thermodynamically preferred partner. Required for the activation of several enzymes such as pyruvate formate-lyase, anaerobic ribonucleotide reductase and cobalamin-dependent methionine synthase.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:7961651}.
Sequence: MADWVTGKVTKVQNWTDALFSLTVHAPVLPFTAGQFTKLGLEIDGERVQRAYSYVNSPDNPDLEFYLVTVPDGKLSPRLAALKPGDEVQVVSEAAGFFVLDEVPHCETLWMLATGTAIGPYLSILQLGKDLDRFKNLVLVHAARYAADLSYLPLMQELEKRYEGKLRIQTVVSRETAAGSLTGRIPALIESGELESTIGLPMNKETSHVMLCGNPQMVRDTQQLLKETRQMTKHLRRRPGHMTAEHYW
InterPro domains: - IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [3-100]
- IPR001433: Oxidoreductase FAD/NAD(P)-binding (domain) [111-222]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [2-101]
- IPR008333: Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain (domain) [19-90]
- IPR033892: Ferredoxin--NADP reductase, bacteria (family) [8-247]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [97-248]
- IPR051930: Flavodoxin/Ferredoxin--NADP Reductase (family) [1-248]
Interaction partners: - 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit
- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta
- 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
- Uncharacterized ferredoxin-like protein YfaE
- Fructose-1,6-bisphosphatase 1 class 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0071949 (FAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0042440 (pigment metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0042168 (heme metabolic process), GO:1901575 (organic substance catabolic process), GO:0046149 (pigment catabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0046700 (heterocycle catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0033013 (tetrapyrrole metabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033015 (tetrapyrrole catabolic process), GO:0006787 (porphyrin-containing compound catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1990204 (oxidoreductase complex)