Protein: BTB/POZ domain-containing protein kctd15 (Potassium channel tetramerization domain-containing protein 15) (Q6DC02)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q8K0E1}.
Sequence: MSRLSLTRSPVSPLAAQGIPLPAQLTKANAPVHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSLKQHYFIDRDGEIFRYILSFLRTCKLLLPDDFKDFNLLYEEARYYQLSPMIKELERWKQEREQRRLANPCDCLVVRVTPDLGERIALSGEKVLIEEIFPETGDVMCNSVNAGWNQDPTHVIRFPLNGYCRLNSVQVLERLFQKGFNVAASCGGGVDSSQFSEYVLCREDRRSHNTNTPIRIKQEPLD
InterPro domains: - IPR048595: BTB/POZ domain-containing protein KCTD1/15-like, C-terminal domain (domain) [141-237]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [32-120]
- IPR045904: KCTD15, tetramerisation-type BTB domain (domain) [29-127]
- IPR000210: BTB/POZ domain (domain) [30-132]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [27-132]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0198738 (cell-cell signaling by wnt), GO:0009888 (tissue development), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0007420 (brain development), GO:0048863 (stem cell differentiation), GO:0060037 (pharyngeal system development), GO:0007399 (nervous system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0016055 (Wnt signaling pathway), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0060070 (canonical Wnt signaling pathway), GO:0014033 (neural crest cell differentiation), GO:0043009 (chordate embryonic development), GO:2001141 (regulation of RNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)