wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: PLEKHG6 (A0A2X0TW08)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
InterPro domains: - IPR000219: Dbl homology domain (domain) [161-353]
- IPR001849: Pleckstrin homology domain (domain) [409-511]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [142-373]
- IPR042918: Pleckstrin homology domain-containing family G member 6 (family) [1-790]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [385-515]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0051056 (regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (EC 2.4.1.222) (O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) (Q8JHF2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Involved in the correct formation of boundaries in the somites and hindbrain (By similarity). Required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain.
Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Sequence: MLKTYRGKVVVSLAGATVTCLGFLLFLSQHQRIQADGMQNESEVGLRSLQSLGDSETDDGAQPEQNAKKGFSAYFSKLTRSRREADKPSEAPGAATDAPPAEDISADDIFIAVKTTKKFHRSRLDLLLDTWISRNMRQTYIFTDGEDEELKKKIGSHAINTNCSAAHSRQALSCKMAVEYDKFIESGKKWFCHVDDDNYVNTKTLVKLLSNYPHTQDMYIGKPSLDRPIEATERLGDNKMRPVNFWFATGGAGFCISRGLALKMSPWASGGHFMNTAEKIRLPDDCTIGYIIESVLGVSLTRSSLFHSHLENLQQVSKSEVHKQITLSYGMFENKRNIINMKGAFSVEEDPSRFKSVHCLLYPDTPWCPPQVAY
InterPro domains: - IPR003378: Fringe-like, glycosyltransferase domain (domain) [103-353]
- IPR017374: Fringe (family) [1-374]
Interaction partners: - Neurogenic locus notch homolog protein 1
- Neurogenic locus notch homolog protein 2 precursor
- Notch receptor 1b.
- Notch receptor 3.
- Beta-1,3-N-acetylglucosaminyltransferase manic fringe
- Beta-1,3-N-acetylglucosaminyltransferase radical fringe
- Hairy-related 1.
- Mesoderm posterior ab.
- Homeobox protein unc-4 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0008375 (acetylglucosaminyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0003002 (regionalization), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0021593 (rhombomere morphogenesis), GO:0048859 (formation of anatomical boundary), GO:0021546 (rhombomere development), GO:0007420 (brain development), GO:0035282 (segmentation), GO:0007399 (nervous system development), GO:0021591 (ventricular system development), GO:0007417 (central nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: RNA helicase (EC 3.6.4.13) (E3MYG7)
Organism: Caenorhabditis remanei (Caenorhabditis vulgaris)
Function: Not known
Sequence: MNTQYYANQNGQQQQPGQGWSSSSYSQQGNVASSGYYSGGFGQTSSPSNGYAIQQSMAPNGMGQMVSSQQTGYIPPYYPGQQQFQMGYSENFENFEDNGSSNGYNNFSDSGNGYNNKCYSGGETNGWGGASAEYTADNLFHRTNSGINFDKYENIPVEVSGDAVPAAIENFSEAGFGPAVMENVTHSGYTKPTPVQKHSIPTLLANRDLMSCAQTGSGKTAAFLLPIIQHIMAGGPEMIKTPAFTNGRRTYFPSALVLSPTRELAIQIHKEASKFSYKTNLQTAILYGGRENYRDQVNRLRSGAHILIATPGRLIDIIEQGFIGLAGCRYLVLDEADRMLDMGFEPQIRKIVGQGMPAKTARTTAMFSATFPKEIQLLAKDFLKENYVFLAVGRVGSTSENIEQRLLWVNEMEKRQNLMEILMNEDSTNLVLVFVETKRGANELAYFLNRQQIRSVSIHGDLKQIERERNLEMFRSGQFPILVATAVAARGLDIPNVRHVINYDLPGDSDEYVHRIGRTGRCGNLGIATSFFNDKNRGIGRDLKNLILEANQEVPDWLHQVAAEGRIGGGQRGGNRRFGATDYRRGNGGGSFAGNFNSYNAGGQSAGFGGGSGFGGAFGATRRPFTNGGFGAQSSLSSSSNGGSGGGFGGPRRGGFNNGMSRQNGGGFYSNGGPPATIDHWQAPRA
InterPro domains: - IPR000629: ATP-dependent RNA helicase DEAD-box, conserved site (conserved_site) [332-340]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [169-197]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [130-566]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [188-405]
- IPR044763: Ded1/Dbp1, DEAD-box helicase domain (domain) [171-396]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [193-376]
- IPR001650: Helicase, C-terminal domain-like (domain) [401-562]
Interaction partners: - Pre-mRNA-processing factor 6
- CRE-EFT-1 protein
- Pescadillo homolog
- Uncharacterized protein
- RNA-binding protein 8A
- CRE-MAG-1 protein
- U6 snRNA-associated Sm-like protein LSm7
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
- eIF-4F 25 kDa subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010494 (cytoplasmic stress granule), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Ferredoxin (P83522)
Organism: Hordeum vulgare (Barley)
Function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Subcellular location: Plastid, chloroplast {ECO:0000250|UniProtKB:P00228}.
Sequence: ATYKVKLVTPEGEVELEVPDDVYILDQAEEEGIDLPYSCRAGSCSSCAGKLVSGEIDQSDQSFLDDDQMEEGWVLTCAAYPKSDVVIETHKEEELTA
InterPro domains: - IPR036010: 2Fe-2S ferredoxin-like superfamily (homologous_superfamily) [2-95]
- IPR001041: 2Fe-2S ferredoxin-type iron-sulfur binding domain (domain) [3-93]
- IPR010241: Ferredoxin [2Fe-2S], plant (family) [1-96]
- IPR006058: 2Fe-2S ferredoxin, iron-sulphur binding site (binding_site) [39-47]
- IPR012675: Beta-grasp domain superfamily (homologous_superfamily) [1-97]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0008198 (ferrous iron binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Disease resistance protein (TIR-NBS-LRR class) family (F4JNL1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MTNSSQSRKPQVFISFRGKAQRKTLVSFIKSKLEEISEINVFMDEYEIRGRPITTLFERIRESSIALVIFSDKYPESRWCLDELVEIKKQMETGSIVPFPIFYKVKAESVKNQTGHFRNVLLKTEEDVRKKVDRSNIRSILETEDMIWGWRQALVSVGGRMGFSYNHKCDNDFVNDIVVQIKKMLADLSPSPRNGLKIIERPQMHPQEEVTSLLQALNLKKSDLEDLIHINGVVSHGTDRLVFLDLISLQNPILADRLIELVQAGRNLLVLLGSLEYYNKGFTFKRIFLPKKSQQLPGYTVVAESNDNLRNHEVSYSDTVLTCFSFLCNILKRSEMKIDPLSQRVFIGLGEKHLGKFLVSSLKEELESNQILVYVEDETKSRIKESGVAVVFFSKKYPNSEKCLDELVEIKKLMDAGKIDPLPVFYSLKDEPVKNLKGYFLNRLLKIENEVRKNIKTRDDKSILDTEAKIWGWRDALSSIASRPGLSYELSTDDVFVSDIVTKVNELFASRERKKTEAATTVVKTLDADDLFYSRTSFLQAIDRDITDFESFTDIPNGLVLLRLKGHTNLVFLKLSSHENLLQVLYLLSLDFNKRGGEAESIVTSASGSIVAASSMFQPLDNSIRIDLNRQKYAT
InterPro domains: - IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [2-515]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [8-515]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds), GO:0003953 (NAD+ nucleosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0019674 (NAD metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Splicing factor ESS-2 (ES2 similar protein 2) (P34420)
Organism: Caenorhabditis elegans
Function: Regulates pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:25194163}.
Sequence: MSSFDKNDERAQLMVPKSINEGKVVKLSQKTLVTKKIERQVVPEEKYIAGLDKIIEKDYFPHLKKMQAQKEYLEAVANKDINKIKELQMKFCSTGSVRTDRSFRTPITTRSTTEAPDVSSFDADTPGPSSASTSSAHDWMQSPMPFANEEGDNEALNRKRKKKKEETLTSYLNKYTSEDNASFEELAKVMREREDARRPWVYKAEEEHNKNLVTRQAIAAEADVQLALKHAVDADDNRPLNVDNWAYKAWNTVLFNPDGAALTPAEIADAARKQQTEINKRGTRFPDSGKLKPSDEAMTRAAVSHALANAGKVDFLGNEVTPANSFKLLETPNPNPDDMDSPLMTWGEIDGTPFRLDAPDVTEHSLPGAAPVFKIPEVPYREKIAQSMNDSIAAKYRDKRKVAMRAAEGAHFSRTPGFGSKRVSDKLAQLSPAAQKLATKKLGLKMLPAHKSPFASPKIMSNWSRPSSSKRSTTPGSAWSRGSTTPGSSWSQGAQTPGTPGIESMIRRKGDNVGPSTSAGAADRANAGDFF
InterPro domains: - IPR019148: Nuclear protein DGCR14/ESS-2 (family) [13-488]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0007275 (multicellular organism development), GO:0048856 (anatomical structure development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Large ribosomal subunit protein eL39 (60S ribosomal protein L39) (Ribosomal protein 46) (O16130)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MAAHKSFRIKQKLAKKLKQNRSVPQWVRLRTGNTIRYNAKRRHWRRTKLKL
InterPro domains: - IPR020083: Large ribosomal subunit protein eL39, conserved site (conserved_site) [30-46]
- IPR000077: Large ribosomal subunit protein eL39 (family) [1-51]
- IPR023626: Large ribosomal subunit protein eL39 domain superfamily (homologous_superfamily) [1-51]
Interaction partners: - Large ribosomal subunit protein eL6
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS25
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS8
- Large ribosomal subunit protein eL29
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL28
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Galactose-binding lectin (CCL) (C0HLX7)
Organism: Chondrilla caribensis (Chicken liver sponge)
Function: Galactose-binding lectin. Displays antibacterial and hemagglutinin activity. Inhibits the growth of L.infantum promastigotes by damaging their membrane integrity and inducing cell apoptosis via the production of reactive oxygen species (ROS). Inhibition of L.infantum promastigotes appears to increase with time (MIC=1.2 uM/ml after 24 hours, MIC=0.9 uM/ml after 48 hours and MIC=0.6 uM/ml after 72 hours). Agglutinates Gram-negative and Gram-positive bacteria including E.coli, S.aureus and S.epidermidis, and inhibits biofilm formation by S.aureus and S.epidermidis. Displays hemagglutination activity towards all types of human erythrocytes (O, A and B) and rabbit erythrocytes.
Sequence: TYAEVESFGVGQSATAVYTAPGDGRDLNITIDADGGYVIHMDYRFDWGGNPSTGKPWEDILILNSKPAQTWGPQQHVNNFYFTPGTHVTLGDKSNDGHFAIIADGIQVATYDHRLPVNSVKEVKFSTTAGSGTDIWDLLLLP
InterPro domains: - IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [6-125]
- IPR001079: Galectin, carbohydrate recognition domain (domain) [1-141]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030246 (carbohydrate binding), GO:0070492 (oligosaccharide binding), GO:0048030 (disaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031341 (regulation of cell killing), GO:0010942 (positive regulation of cell death), GO:0051709 (regulation of killing of cells of another organism), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0010941 (regulation of cell death), GO:0009611 (response to wounding), GO:0044003 (modulation by symbiont of host process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0052572 (response to host immune response), GO:0052553 (modulation by symbiont of host immune response), GO:0052167 (modulation by symbiont of host innate immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)
Protein: Ribosome biogenesis protein NOP53 (Q9NEU5)
Organism: Caenorhabditis elegans
Function: May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit.
Subcellular location: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NZM5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9NZM5}.
Sequence: MVAGKRTGAAKGSRHNKKYWRKGTNIDDIEDSIHIKSRQAATGGVISEMKDEDLFIVDRTATANKPVVPKLTKKQQAALEKITKNITQEHVTLPKPSTTSKILKKPAKLPRGNAILALKKGPKAAAPAAKKKNFDVWTTDLTPKIPKSKLENQEAAEHFLKVVKKKQPKTPGKSITSLLPAVQIAEGGASYNPESAEYQEYVAKIAGEEQKLIDHEAKIKAGIEPQWEKVTTEHERFLEMAEGLRIHPKYGKDDEEEEEAGNSEKSMKTGGEAEPKSQRVECDRMTKEQKKKKAKAQKLDKEEKRRLEEKAKEQDSHNVYRTKQLHKELDEEEKQRHEESEVRKKEKLINKLTKRQQLGKGKFVDAEDPFLLQEELTGNLRQLKPQGHVLDDRMKSLQRRNMLPIGGDKEKRRIKNRLKSKVVEKRSAKNIVKGSRVI
InterPro domains: - IPR011687: Ribosome biogenesis protein Nop53/GLTSCR2 (family) [1-438]
Interaction partners: - Putative rRNA methyltransferase
- Nucleolar GTP-binding protein 1
- mRNA transport homolog 4
- Nucleolar GTP-binding protein 2
- Ribosomal L1 domain-containing protein
- Protein SDA1 homolog
- RRM domain-containing protein
- NLE domain-containing protein
- Ribosome production factor 2 homolog
- Pescadillo homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0019843 (rRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0007275 (multicellular organism development), GO:0048856 (anatomical structure development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)