Protein: Protein transport protein Sec23A (SEC23-related protein A) (Q7SZE5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436}. Note=Enriched at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000250|UniProtKB:Q15436}.
Sequence: MATFQEFIQQNEDRDGVRFSWNVWPSSRLEATRMVVPVASLFTPLKERPDLPPIQYEPVLCSRATCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPTYAGISEVNQPAELLPQFSTIEYVVQRGPQMPLNFLYVVDTCMEDDDLQALKESLQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLNAKQLQEMLGLTKPAAAQAGRGPQQPQVPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVTQGKRPLRSLGVALSIAVGLLECTFPNTGARIMAFIGGPATQGPGMVVGDELKTPIRSWHDIEKDNAKFMKKATKHYEALANRAAANGHIIDIYACALDQTGLLEMKCCTNYTGGYMVMADSFNTSLFKQTFQRVFTKDVQGCFKMALAGTLEIKTSREIKISGAIGPCVSLNAKGPCVSENEMGTGGTSQWKICGLDPNTTLGFYFEVVNQHNAPIPQGGRGAIQYVTQYQHSSGQRRIRVTTIARNWADAQSQIQSIAASFDQEAAAILMARLAVYKAETEEGPDVLRWLDRQLIRLCQKFGDYHKEDPNSFRFSETFSLYPQFMFHLRRSPFLQVFNNSPDESTYYRHQFMRQDLTQSLIMVQPILYAYSFNGPPEPVLLDSSSILPDRILLMDTFFQILIYHGETVSQWRKAGYQDMPEYENFRHLLQAPVDDAQELLHTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQESGAPILTDDVSLQVFMDHLKKLAVSSAA
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [624-746]
- IPR036180: Gelsolin-like domain superfamily (homologous_superfamily) [621-761]
- IPR037364: Protein transport protein Sec23 (family) [7-761]
- IPR036174: Zinc finger, Sec23/Sec24-type superfamily (homologous_superfamily) [49-123]
- IPR006900: Sec23/Sec24, helical domain (domain) [518-616]
- IPR006895: Zinc finger, Sec23/Sec24-type (domain) [58-98]
- IPR037550: Sec23, C-terminal (domain) [610-730]
- IPR012990: Sec23/Sec24, beta-sandwich (domain) [402-504]
- IPR036175: Sec23/Sec24 helical domain superfamily (homologous_superfamily) [518-620]
- IPR006896: Sec23/Sec24, trunk domain (domain) [126-390]
- IPR007123: Gelsolin-like domain (domain) [632-718]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [127-400]
Interaction partners: - Protein SEC13 homolog
- small monomeric GTPase
- Protein transport protein Sec31A
- Protein transport protein Sec31A
- Vesicle-trafficking protein SEC22b-B
- SEC16 homolog B, endoplasmic reticulum export factor.
- Protein transport protein Sec24D
- Protein transport protein Sec24A isoform X2
- Protein transport protein Sec24C
- small monomeric GTPase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0034101 (erythrocyte homeostasis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0048872 (homeostasis of number of cells), GO:0030097 (hemopoiesis), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0030218 (erythrocyte differentiation), GO:0048702 (embryonic neurocranium morphogenesis), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0061448 (connective tissue development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0030099 (myeloid cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061515 (myeloid cell development), GO:0043009 (chordate embryonic development), GO:0048821 (erythrocyte development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0070971 (endoplasmic reticulum exit site), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)