Protein: Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8) (Q62419)
Organism: Mus musculus (Mouse)
Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Associated with postsynaptic endosomes in hippocampal neurons. {ECO:0000250}.
Sequence: MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKDMEKKVDVTSKAVAEVLVRTIEYLQPNPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMVRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCDKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILEELADKLKRRVREASSRPKREFKPRPREPFELGELEQPNGGFPCAPAPKITASSSFRSSDKPIRMPSKSMPPLDQPSCKALYDFEPENDGELGFREGDLITLTNQIDENWYEGMLHGQSGFFPLSYVQVLVPLPQ
InterPro domains: - IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-247]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [300-365]
- IPR050384: Endophilin/SH3RF (family) [15-362]
- IPR035824: Endophilin-A, SH3 domain (domain) [309-363]
- IPR001452: SH3 domain (domain) [306-365]
- IPR004148: BAR domain (domain) [5-249]
Interaction partners: - Synaptojanin-1
- Synaptojanin-2
- E3 ubiquitin-protein ligase CBL
- Endophilin-A1
- Endophilin-A3
- E3 ubiquitin-protein ligase CBL-B
- E3 ubiquitin-protein ligase CBL-C
- Activity-regulated cytoskeleton-associated protein
- Epidermal growth factor receptor substrate 15
- Programmed cell death 6-interacting protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0044325 (transmembrane transporter binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0051020 (GTPase binding), GO:0017124 (SH3 domain binding), GO:0019902 (phosphatase binding), GO:0001664 (G protein-coupled receptor binding), GO:0031690 (adrenergic receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0036465 (synaptic vesicle recycling), GO:0099504 (synaptic vesicle cycle), GO:0016192 (vesicle-mediated transport), GO:0043933 (protein-containing complex organization), GO:0140238 (presynaptic endocytosis), GO:0022411 (cellular component disassembly), GO:0048488 (synaptic vesicle endocytosis), GO:0006897 (endocytosis), GO:0099003 (vesicle-mediated transport in synapse), GO:0032984 (protein-containing complex disassembly), GO:0051261 (protein depolymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0099523 (presynaptic cytosol), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0099522 (cytosolic region), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0097470 (ribbon synapse), GO:0031982 (vesicle), GO:0098978 (glutamatergic synapse), GO:0097708 (intracellular vesicle)