Protein: AP complex subunit sigma (Q9VDC3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. Membrane, coated pit {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004277}.
Sequence: MIRFILIQNRAGKTRLAKWYMNFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIVYRRYAGLYFCICVDVNDNNLCYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYSVVDEMFLAGEIRETSQTKVLKQLLTLNSLE
InterPro domains: - IPR011012: Longin-like domain superfamily (homologous_superfamily) [1-137]
- IPR000804: Clathrin adaptor complex, small chain (conserved_site) [57-67]
- IPR027156: AP-2 complex subunit sigma (family) [1-141]
- IPR022775: AP complex, mu/sigma subunit (domain) [1-141]
- IPR016635: Adaptor protein complex, sigma subunit (family) [1-142]
Interaction partners: - AP-2 complex subunit alpha
- Adaptor protein complex 2, mu subunit, isoform A
- AP complex subunit beta
- Clathrin heavy chain
- AP-1 complex subunit gamma
- AT02057p
- Adaptor protein complex 1, mu subunit
- Epidermal growth factor receptor pathway substrate clone 15, isoform A
- AP-3 complex subunit delta
- Clathrin light chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding), GO:0030276 (clathrin binding), GO:0140312 (cargo adaptor activity), GO:0035615 (clathrin adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0006897 (endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005905 (clathrin-coated pit), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0048475 (coated membrane), GO:0030119 (AP-type membrane coat adaptor complex), GO:0098797 (plasma membrane protein complex), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030139 (endocytic vesicle), GO:0030132 (clathrin coat of coated pit), GO:0043231 (intracellular membrane-bounded organelle), GO:0030118 (clathrin coat), GO:0098588 (bounding membrane of organelle), GO:0030131 (clathrin adaptor complex), GO:0012506 (vesicle membrane), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0030122 (AP-2 adaptor complex), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0030666 (endocytic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0030125 (clathrin vesicle coat), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0045334 (clathrin-coated endocytic vesicle), GO:0030669 (clathrin-coated endocytic vesicle membrane), GO:0030128 (clathrin coat of endocytic vesicle), GO:0030665 (clathrin-coated vesicle membrane)