Protein: Protein teflon (Q7K4M4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Specifically required in males for proper segregation of autosomal bivalents at meiosis I. Expression is required in the male germ line prior to spermatocyte stage S4. May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections.
Subcellular location: Nucleus {ECO:0000269|PubMed:11139508, ECO:0000269|PubMed:16816414}. Chromosome. Note=Male meiotic chromosomes. {ECO:0000269|PubMed:11139508, ECO:0000269|PubMed:16816414}.
Sequence: MSKFLDMLSGSQCVSLEKCGDVVVSTNDCMIALYCHFCRDLFTQLPEFLRHLQSNHSDVLHFTKEHNVYSVEELLSGEQGKAHEDAQSAGHNSSSGDSSSLMNSEDSRAIEGSEDNSDNSPMKPEQIGKQSEINLLAEVTNILLQTNDKELKPENGVFNRPRKKANNESSSLKICDLKSHTIARTSRKRMSMVKNRILRVLDSDLSAKLEIKPPEPNSKLSITEPIQEDNIPGTCFDTPTKPIPSSSQLSVRKSSLTEANQICTKYAEKKTAPTMPKLLNCVPKPILTSQQAHTNAEISEINETYHLAASQVTKTTKTFPVKITQIDILQPVKLPKTLITPINEEGVSDQVENSTNNINNAQSLPKENTKKFFKKRSELGIKAQGSPNKFFKIIKSKANPIIVKRVQTTSAKASTNKIQIRSNDKTNCFASEFNSTKIRKLKMENCVDLKSEDPCANTNTRLNKLATISSCEILKAVGLPAITDNPIEDTLLPDELETIRKKADQFIKIYRKYDSIWNYRKICPPAKPDFISQQIFALTREVNKTMLCNLANSDIKGIINQISVWHYNIYTQYIDLDTISENARYTLKLFSFLPVSFAYFCKCCDDIFILKKEYLKHLISHQVRFQCTKCIKVFKYKGYYEKHLRNAHS
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [33-649]
Interaction partners: - Something that sticks like glue, isoform A
- Stromalin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006325 (chromatin organization), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0006338 (chromatin remodeling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0000785 (chromatin), GO:0000792 (heterochromatin), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0043228 (non-membrane-bounded organelle), GO:0005721 (pericentric heterochromatin), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)