Protein: Lactotransferrin (B7ZAL5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLHQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAENAGDVAFVKDVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK
InterPro domains: - IPR018195: Transferrin family, iron binding site (binding_site) [67-575]
- IPR001156: Transferrin-like domain (domain) [1-655]
- IPR016357: Transferrin (family) [1-666]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0008289 (lipid binding), GO:1901681 (sulfur compound binding), GO:0140678 (molecular function inhibitor activity), GO:0140677 (molecular function activator activity), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0043169 (cation binding), GO:0004857 (enzyme inhibitor activity), GO:0008047 (enzyme activator activity), GO:0008201 (heparin binding), GO:0005539 (glycosaminoglycan binding), GO:0017171 (serine hydrolase activity), GO:0061134 (peptidase regulator activity), GO:0019207 (kinase regulator activity), GO:0001530 (lipopolysaccharide binding), GO:0019209 (kinase activator activity), GO:0061135 (endopeptidase regulator activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0019887 (protein kinase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0004866 (endopeptidase inhibitor activity), GO:0030295 (protein kinase activator activity), GO:0004252 (serine-type endopeptidase activity), GO:0005506 (iron ion binding), GO:0043539 (protein serine/threonine kinase activator activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0048525 (negative regulation of viral process), GO:0044403 (biological process involved in symbiotic interaction), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0032103 (positive regulation of response to external stimulus), GO:0045069 (regulation of viral genome replication), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0001817 (regulation of cytokine production), GO:0002251 (organ or tissue specific immune response), GO:1900190 (regulation of single-species biofilm formation), GO:0009887 (animal organ morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0042391 (regulation of membrane potential), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0031349 (positive regulation of defense response), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:1900191 (negative regulation of single-species biofilm formation), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0051702 (biological process involved in interaction with symbiont), GO:0044092 (negative regulation of molecular function), GO:0006952 (defense response), GO:0045071 (negative regulation of viral genome replication), GO:0060249 (anatomical structure homeostasis), GO:0045087 (innate immune response), GO:0043462 (regulation of ATP-dependent activity), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:1903900 (regulation of viral life cycle), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0032102 (negative regulation of response to external stimulus), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0031347 (regulation of defense response), GO:0019730 (antimicrobial humoral response), GO:0045837 (negative regulation of membrane potential), GO:0045089 (positive regulation of innate immune response), GO:0048705 (skeletal system morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0001895 (retina homeostasis), GO:0045669 (positive regulation of osteoblast differentiation), GO:0010468 (regulation of gene expression), GO:0001501 (skeletal system development), GO:0060349 (bone morphogenesis), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0045667 (regulation of osteoblast differentiation), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0043086 (negative regulation of catalytic activity), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0045088 (regulation of innate immune response), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0062207 (regulation of pattern recognition receptor signaling pathway), GO:0002385 (mucosal immune response), GO:0062208 (positive regulation of pattern recognition receptor signaling pathway), GO:0051851 (modulation by host of symbiont process), GO:0060348 (bone development), GO:0042742 (defense response to bacterium), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0031664 (regulation of lipopolysaccharide-mediated signaling pathway), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033688 (regulation of osteoblast proliferation), GO:0051338 (regulation of transferase activity), GO:0032780 (negative regulation of ATP-dependent activity), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0043549 (regulation of kinase activity), GO:0031401 (positive regulation of protein modification process), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide), GO:0034143 (regulation of toll-like receptor 4 signaling pathway), GO:0019731 (antibacterial humoral response), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0032680 (regulation of tumor necrosis factor production), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0045861 (negative regulation of proteolysis), GO:0044788 (modulation by host of viral process), GO:0001932 (regulation of protein phosphorylation), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0042325 (regulation of phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0010951 (negative regulation of endopeptidase activity), GO:0045860 (positive regulation of protein kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:2000117 (negative regulation of cysteine-type endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0009986 (cell surface), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0030139 (endocytic vesicle), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042581 (specific granule), GO:0070820 (tertiary granule), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0071682 (endocytic vesicle lumen), GO:0035580 (specific granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0045335 (phagocytic vesicle), GO:1904724 (tertiary granule lumen)