wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: PslF (Q9I1N3)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Not known
Sequence: MRIALLAPLPPEKNGIADYASHFRNALQGLGIEVATPLAGVAADSANIASRLDSVDWNAFDLVHAELGGGRLGEFIALRELRKRFPRLPLSATVHDPERMVWRRERLPWPLNLLERLPSPLPQAAVVLADPLTLREERAVAQGLTRLVTLTGLGGECLARRMRLPPGRVEVINHGNLEIATVPLPSLDTLRLLYFGFIYRGKGIEDLLEALADLFASAPEMRQRVRLTLAGGTAAEMAFGAGGNYLYQLKAQIAELGLADAIDWNLNLAAADIPRTIQAHHVMVLPYRESKKLGLLGQQRGTSGALSWAAACGRGAITSDARAFAEEVASGNGAIYPQGDVAALSEQLLNLAREPRLAQAWAERAGAIGHARTWPRTALRFQALFNDMVGTVHGT
InterPro domains: - IPR001296: Glycosyl transferase, family 1 (domain) [191-365]
Interaction partners: - PslE
- PslG
- PslJ
- PslH
- PslD
- PslI
- Alginate biosynthesis protein AlgA
- dTDP-Rha:alpha-D-Gal-diphosphoundecaprenol alpha-1,3-rhamnosyltransferase
- PslA
- PslL
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0008653 (lipopolysaccharide metabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0046402 (O antigen metabolic process), GO:0009103 (lipopolysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0009243 (O antigen biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009279 (cell outer membrane), GO:0019867 (outer membrane), GO:0030313 (cell envelope)
Protein: Thialysine N-epsilon-acetyltransferase (EC 2.3.1.-) (O17731)
Organism: Caenorhabditis elegans
Function: Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. Substrate specificity: thialysine > O-(2-aminoethyl)-L-serine > S-(2-aminoethyl)-D,L-homocysteine. Does not act on polyamines, such as spermidine and spermine, nor on diamines putrescine and cadaverine.
Sequence: MKNFEIVTVTPDHAEQLISMIHELAEFEKMKSSVVNTAEKLRKDIENKAVHGFIAFIGEEPAGMNLFYYAYSTWVGQYLHMEDLYIRPQFRRMGLARTLWKKLAELARDKGIVRLEWAVLDWNKNAIALYDTVDYVNLTKSEGWFTFRMDGAAINKFADE
InterPro domains: - IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [3-144]
- IPR000182: GNAT domain (domain) [4-159]
- IPR051016: Diverse Substrate Acetyltransferase (family) [3-160]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0009308 (amine metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006576 (biogenic amine metabolic process), GO:0009310 (amine catabolic process), GO:0042402 (cellular biogenic amine catabolic process), GO:0006595 (polyamine metabolic process), GO:0008216 (spermidine metabolic process), GO:0006598 (polyamine catabolic process), GO:0008215 (spermine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: ShKT domain-containing protein (Q9GYJ3)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MFRQFIISFAIFSVAFACEASESEGPCDGGILVCQTQVCDVAAGQCCPITTAAAVTSTTAAVVTDSDGSTVTTTASSVTVTSTSTTTCADRVNPSTGVSDCSALAYLCNDSTYYTVMTQQCPRTCGRCNSTSTSSTSCVDRVNPSTGVSDCPARAALCNDSNYYTLMTTQCPRTCGRCSTSSSTTSSSTTCADRVNPTTGVSDCPARASLCNNSVYYDIMTTQCPRTCGRCTSSSTISATSSASTTVSSTCVDQVNAATGTSDCPNRRAFCTNSAYISLMRTQCPLTCGFCTAG
InterPro domains: - IPR003582: ShKT domain (domain) [87-292]
Interaction partners: - Helix-loop-helix protein 6
- ShKT domain-containing protein
- Ubiquitin-like domain-containing protein
- Prion-like-
- Nuclear Hormone Receptor family
- EB domain-containing protein
- Flo11 domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008061 (chitin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Brevinin-1DYb (Brevinin-1CDYb) (P0C5W7)
Organism: Rana dybowskii (Dybovsky's frog) (Korean brown frog)
Function: Antimicrobial peptide. Has low activity against the Gram-positive bacterium S.aureus and the Gram-negative bacterium E.coli (MIC<15 uM). Has a strong hemolytic activity.
Subcellular location: Secreted {ECO:0000269|PubMed:17688900}.
Sequence: MFTLKKSLLLLFFLGTISLSLCEEERNAEEERRDYPEERDVEVEKRFLSLALAALPKLFCLIFKKC
InterPro domains: - IPR004275: Frog antimicrobial peptide, propeptide (domain) [2-45]
- IPR012520: Frog antimicrobial peptide, brevinin-1 type (domain) [47-66]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Methoxy mycolic acid synthase MmaA3 (EC 2.1.1.-) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) (A5U028)
Organism: Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
Function: Involved in the biosynthesis of methoxymycolic acid. It catalyzes the O-methylation of the hydroxy group of the hydroxymycolate to form a methyl ether.
Sequence: MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK
InterPro domains: - IPR050723: Cyclopropane Fatty Acid Synthase/Methyltransferase (family) [7-293]
- IPR047672: Cyclopropane mycolic acid synthase, actinobacteria (family) [12-293]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [2-293]
- IPR003333: Cyclopropane mycolic acid synthase (family) [2-293]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0008610 (lipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: GldK (A5FIS8)
Organism: Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / BCRC 14874 / CCUG 350202 / NBRC 14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae)
Function: Not known
Sequence: MKKFIAFAAMLTLVIGCGKSGDKGELVGVTGGKWHPEKPYGMTLVPGGSFIMGKSDGDLANVEDAPTRTVTVRSFYMDETEITNSEYRQFVEWVKDSTMRVRLAILADETGQKSTGDKGKKGGSIADYAFNDSEPDKMTAYDKYMYDNYYSVGTKDDPYAGRKLNKKVKLIRDTKAYPDEYYAEVMDSMYLPIEESYNGLRTIDVNKLKFRYSWMDIQAAAKAKVGKRKDFVKTEQVNVYPDTTVWIKDFAYSYNEPMHNDYFWHKAYGDYPVVGVTWKQAKAFCAWRTLNKNSYIKSKKKGRDLVNAFRLPTEAEWEYAARGGLESATYPWGGPYTKSDRGCFMANFKPNRGDYAADEALYTVEAKSYEQNGYGLYNMAGNVSEWTDSAYNPNAYEYVSTMNPNVIDGNNQRKVVRGGSWKDVAYFLQVSTRDHEYADSARSYIGFRTVQDYMGTQVTGGGRK
InterPro domains: - IPR051043: Sulfatase Modifying Factor and Kinase (family) [245-452]
- IPR005532: Sulfatase-modifying factor enzyme-like domain (domain) [41-450]
- IPR042095: Sulfatase-modifying factor enzyme superfamily (homologous_superfamily) [31-457]
- IPR016187: C-type lectin fold (homologous_superfamily) [39-452]
- IPR019866: Gliding motility-associated lipoprotein GldK (family) [1-458]
Interaction partners: - GldL
- GldM
- GldN
- SprA
- SprT
- SprE
- GldD
- GldB
- Gliding motility lipoprotein GldH
- GldO
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0043169 (cation binding), GO:0016670 (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0009100 (glycoprotein metabolic process), GO:0006517 (protein deglycosylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)
Protein: Prolyl endopeptidase (EC 3.4.21.-) (Q9V9P5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSRSDALVQSPTDLSRSVEEASLRIVYPEARKDGRFEEMIHGYKIKDVYRWLEDPDSVDTQQFVNAQNNISQSFLERSAERENINSKLTKLWNFPKYGCPMRHGNYYYFFKNTGLQNQSVLMQQKTLESPESIFLDTNSISSDGTTAISHIKFSEDGAFMAYGLSESGSDWNKIRIRNTKEGIDLPEILEKVKFSNVSWTKDSKGFFYGRYTDQDGIFDGSETKLAENQKLYYHLLGESPHQDILIAEFPEHPSWRFKTDISDCGKYLILSISHTVRDNMLYYAELGSEEKNAFQLELKPIVDKFEADFDYITNEGSNLYFHTNKDAPNYRVIVIDVNNPAEEHWTTPIPEHKKDVLEWAKCVDGNKLVVCYNCDVKHILQARDLSTGKLIRQFGLDIGSINGISGKKSNSEIFYGFSSFLSPGIIFYYDFAKPSEKPTVLREISLNLEGFSRDNYSVEQVFYKSTDDTDIPMFIVQRKRDIAEPRPCLLYGYGGFNYSLMPSFGILSLMFMDTFDGVLAFPNLRGGGEYGMEWHNGGRMLSKQNVFNDFQAAAEFLTKNNYTTKDRLAIQGASNGGLLVGACINQRPDLFGAAVAQVGVMDMLRFHKFTIGHAWCSDYGNPDEKVHFANLIKFSPLHNVHIPLNPNQEYPSTLILTADHDDRVSPLHSYKFVAALQEAVRYSEYQLNPILLRVYTKAGHGAGKPTKMRISEATDIITFFKKTLNVDCINL
InterPro domains: - IPR002471: Peptidase S9, serine active site (active_site) [549-579]
- IPR023302: Peptidase S9A, N-terminal domain (domain) [28-439]
- IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [38-724]
- IPR002470: Peptidase S9A, prolyl oligopeptidase (family) [487-672]
- IPR051167: Prolyl oligopeptidase and macrocyclase (family) [22-728]
- IPR001375: Peptidase S9, prolyl oligopeptidase, catalytic domain (domain) [509-725]
Interaction partners: - FI08533p
- Mitochondrial 2-oxodicarboxylate carrier
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0019953 (sexual reproduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)
Protein: Carboxypeptidase (CP) (EC 3.4.17.-) (P86516)
Organism: Sabellastarte magnifica (Feather duster)
Function: Carboxypeptidase that catalyzes the release of hydrophobic and acidic C-terminal amino acids.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P00732}.
Sequence: AFDLNDFNTLEDTYDQMNVFQLSEAGLTHEGRDMKSWIDSLTHCRSHLDEDVFMFKRNEPDSGSACVGTDLNRSSNNPCSDTYGGSGPASALETRHSYSQQYEDELNQRQRYEPSGTTVNNLLNKDAGSIYSYTPELR
InterPro domains: - IPR000834: Peptidase M14, carboxypeptidase A (domain) [1-138]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0075528 (modulation by virus of host immune response), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0019054 (modulation by virus of host cellular process), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0019049 (mitigation of host antiviral defense response), GO:0052572 (response to host immune response), GO:0030682 (mitigation of host defenses by symbiont), GO:0052553 (modulation by symbiont of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Disease resistance protein (TIR-NBS class) (F4IF04)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MNTIFKKLSCFKKKVKSLRIFESRSLSSSSSSSFTPQKFDVFLSFRGKDTRKNFVSFLYKALVSKGIRTFKDDEELERGRPIPPELRQAIKGSRIAVVVVSVTYPASSWCLEELREILKLEKLGLLTVIPIFYEINPSDVRRQSGVVSKQFKKHEKRQSRERVKSWREALTKLASLSGECSKNWEDLSNRFSKFRFLSLFLKGLRLCFSREDDSKLVDGITEKISTKLFSEKPRNDNILIGIDQHMGELYPLFNLNSNEDVQVIGIWGRGSNGRSALASHVYQNIKHHFEAHCFLEDVRRISLHFRDSHLQDELLSNMQGEGLTTKNCHRCLKTIKARLRNKKVLLVANDVDKLEQFDALAEEFSWFGPGSRIIITTQDRQLLISSVVRSVYEVKLLRCYAVRELFRSNAFKERERDDPVGFDQSTYRAMYISGHVFLTLRYIFTLLCDRVNVTPFFYIWMCHLCMDLCTIHLVNYFILKTVHNKFI
InterPro domains: - IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [28-227]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [37-228]
- IPR002182: NB-ARC (domain) [255-417]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [228-452]
- IPR044974: Disease resistance protein, plants (family) [38-450]
Interaction partners: - AT4g11790/T5C23_220
- At4g21108/At4g21108
- F-box/kelch-repeat protein At5g42350
- Receptor-like protein 18
- Subtilisin-like protease SBT2.6
- At1g31410
- Protein PECTIC ARABINOGALACTAN SYNTHESIS-RELATED
- Putative clathrin assembly protein At4g40080
- Expressed protein
- At1g72880
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0006952 (defense response), GO:0010942 (positive regulation of cell death), GO:0043207 (response to external biotic stimulus), GO:0010941 (regulation of cell death), GO:0009620 (response to fungus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Trifunctional (S)-stylopine synthase/(S)-nandinine synthase/(S)-canadine synthase (STS) (EC 1.14.19.64) (EC 1.14.19.68) (EC 1.14.19.73) (Cytochrome P450 719A13) (B1NF19)
Organism: Argemone mexicana (Mexican prickly poppy)
Function: Methylenedioxy bridge-forming cytochrome P450 involved in the biosynthesis of isoquinoline alkaloids. Converts (S)-cheilanthifoline to (S)-stylopine, (S)-scoulerine to (S)-nandinine and (S)-tetrahydrocolumbamine to (S)-canadine. Can be involved in both sanguinarine and berberine biosynthesis. Catalyzes an oxidative reaction that does not incorporate oxygen into the product.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MEEKIMTNNSPWILTSSTTTTTTILLSLLFTIFIILRRNKSSSSKMVWPTGPKTLPIIGNMNILGGTALHVVLHNLAKTYGNVMTIWIGSWRPVIVVSDIDRAWEVLVNKSSDYSARDMPEITKLATADWKTISSSDSGPFWTNLRKGLQNVALSPQNLSSQSKFQERDIIKTIQNLKEEAKMNNGIVKPLDHLKKAMVRLISRLIYGQDFDNDEYVEEMHHTIEELIRVSGYARLAEAFYYAKYLPSHKKAVREVLQANQRVQNLVRPLLSLNSPTNTYLHFLRSQNYEDEVIIFAIFEAYLLGVDSTSSTTAWALAYLIREPNVQEKLYEELKNFTNDNDRKMVKFEDLNKLQYLQAVVKETMRMKPIAPLAIPHKACRETSLMGRKVNQGTRVMVNIYALHHNQNVWKEPYKFNPERFLQKNQDGVDGKAMEQSLLPFSAGMRICAGMELGKLQFSFALANLVNAFKWSCVSDGVFPDMSDQLGFVLLMKTPLEAGIVPRM
InterPro domains: - IPR001128: Cytochrome P450 (family) [49-492]
- IPR002401: Cytochrome P450, E-class, group I (family) [77-471]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [42-504]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [441-450]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016717 (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0019748 (secondary metabolic process), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009821 (alkaloid biosynthetic process), GO:0009820 (alkaloid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)