Protein: Pleiotropic ABC efflux transporter of multiple drugs CDR1 (Q5ANA3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including anisomycin, cycloheximide, fluconazole, miconazole, ketoconazole, itriconazole, nystatin, terbinafine, amorolfine, brefeldin A, amphotericin B, fluphenazine, as well as estrogen. Plays a role in farnesol-induced apoptotic process through glutathione efflux activity. Mediates in-to-out translocation of membrane phospholipids including aminophospholipids and thus regulates asymmetric distribution of phosphatidylethanolamine. Exhibits nucleoside triphosphatase activity
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Accumulates at membrane rafts. Both ergosterol and sphingolipids are essential for targeting to membrane rafts. Mislocalizes to the vacuole in absence of FZO1
Sequence: MSDSKMSSQDESKLEKAISQDSSSENHSINEYHGFDAHTSENIQNLARTFTHDSFKDDSSAGLLKYLTHMSEVPGVNPYEHEEINNDQLNPDSENFNAKFWVKNLRKLFESDPEYYKPSKLGIGYRNLRAYGVANDSDYQPTVTNALWKLATEGFRHFQKDDDSRYFDILKSMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSPHDIERHYRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRETYAKHMASVYMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGANIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLFDKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAEREPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVECERSNTRETYRESHVAKQSNNTRPASPYTVSFFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVFYNLSQTTGSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADALASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMSHLFRSIGAVSTSISGAMTPATVLLLAMVIYTGFVIPTPSMLGWSRWINYINPVGYVFESLMVNEFHGREFQCAQYVPSGPGYENISRSNQVCTAVGSVPGNEMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFFLAIYIALTEFNKGAMQKGEIVLFLKGSLKKHKRKTAASNKGDIEAGPVAGKLDYQDEAEAVNNEKFTEKGSTGSVDFPENREIFFWRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNCLSERVTTGIITDGERLVNGHALDSSFQRSIGYVQQQDVHLETTTVREALQFSAYLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAGEGLNVEQRKRLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILCTIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYFEKYGADPCPKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAELSKLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSKIFLVVSAALFNGFSFFKAKNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDVYEVREAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNATPTDSVNPRGVLMWMLVTAFYVYTATMGQLCMSFSELADNAANLATLLFTMCLNFCGVLAGPDVLPGFWIFMYRCNPFTYLVQAMLSTGLANTFVKCAEREYVSVKPPNGESCSTYLDPYIKFAGGYFETRNDGSCAFCQMSSTNTFLKSVNSLYSERWRNFGIFIAFIAINIILTVIFYWLARVPKGNREKKNKK
InterPro domains: - IPR034001: ATP-binding cassette transporter, PDR-like subfamily G, domain 1 (domain) [167-386]
- IPR010929: CDR ABC transporter (domain) [716-807]
- IPR029481: Pleiotropic ABC efflux transporter, N-terminal domain (domain) [45-146]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [154-1100]
- IPR003593: AAA+ ATPase domain (domain) [179-1079]
- IPR013525: ABC-2 type transporter, transmembrane domain (domain) [496-1392]
- IPR034003: ATP-binding cassette transporter, PDR-like subfamily G, domain 2 (domain) [858-1085]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [303-317]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [150-1103]
- IPR005285: Pleiotropic drug resistance protein PDR/CDR (family) [94-1492]
Interaction partners: - Multidrug resistance protein 1
- Lanosterol 14-alpha demethylase
- Major facilitator superfamily multidrug transporter FLU1
- Transcription factor TAC1
- Sterol uptake control protein 2
- Delta(7)-sterol 5(6)-desaturase ERG3
- ATP-binding cassette transporter
- Sphingoid long-chain base transporter RSB1
- MFS antiporter QDR1
- Sterol 24-C-methyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0140326 (ATPase-coupled intramembrane lipid transporter activity), GO:0005319 (lipid transporter activity), GO:0140303 (intramembrane lipid transporter activity), GO:0005548 (phospholipid transporter activity), GO:0008525 (phosphatidylcholine transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051179 (localization), GO:0140352 (export from cell), GO:0051234 (establishment of localization), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0140115 (export across plasma membrane), GO:0006810 (transport), GO:0046618 (xenobiotic export from cell), GO:0009636 (response to toxic substance), GO:0042908 (xenobiotic transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)