Protein: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) (HPRT B) (P00493)
Organism: Mus musculus (Mouse)
Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
Subcellular location: Cytoplasm.
Sequence: MPTRSPSVVISDDEPGYDLDLFCIPNHYAEDLEKVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVKQYSPKMVKVASLLVKRTSRSVGYRPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
InterPro domains: - IPR005904: Hypoxanthine phosphoribosyl transferase (family) [35-208]
- IPR029057: Phosphoribosyltransferase-like (homologous_superfamily) [1-218]
- IPR050408: Hypoxanthine-guanine phosphoribosyltransferase (family) [7-218]
- IPR000836: Phosphoribosyltransferase domain (domain) [42-195]
Interaction partners: - Adenine phosphoribosyltransferase
- GMP synthase
- Purine nucleoside phosphorylase
- Purine nucleoside phosphorylase
- Bifunctional purine biosynthesis protein ATIC
- Adenylosuccinate synthetase isozyme 2
- Adenylosuccinate synthetase isozyme 1
- Guanine deaminase
- AMP deaminase 1
- Inosine-5'-monophosphate dehydrogenase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016763 (pentosyltransferase activity), GO:0106130 (purine phosphoribosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0021575 (hindbrain morphogenesis), GO:0048729 (tissue morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:1901135 (carbohydrate derivative metabolic process), GO:0021680 (cerebellar Purkinje cell layer development), GO:0021696 (cerebellar cortex morphogenesis), GO:0000902 (cell morphogenesis), GO:0021549 (cerebellum development), GO:1901360 (organic cyclic compound metabolic process), GO:0048598 (embryonic morphogenesis), GO:0044283 (small molecule biosynthetic process), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0042221 (response to chemical), GO:1901362 (organic cyclic compound biosynthetic process), GO:1901565 (organonitrogen compound catabolic process), GO:0034404 (nucleobase-containing small molecule biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009116 (nucleoside metabolic process), GO:0048732 (gland development), GO:0009116 (nucleoside metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0030855 (epithelial cell differentiation), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:1901566 (organonitrogen compound biosynthetic process), GO:0060348 (bone development), GO:0009112 (nucleobase metabolic process), GO:0007399 (nervous system development), GO:0002064 (epithelial cell development), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0009116 (nucleoside metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901657 (glycosyl compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0060429 (epithelium development), GO:0006144 (purine nucleobase metabolic process), GO:1901659 (glycosyl compound biosynthetic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009163 (nucleoside biosynthetic process), GO:0042278 (purine nucleoside metabolic process), GO:0009119 (ribonucleoside metabolic process), GO:0006144 (purine nucleobase metabolic process), GO:1901659 (glycosyl compound biosynthetic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0009163 (nucleoside biosynthetic process), GO:0042278 (purine nucleoside metabolic process), GO:0009119 (ribonucleoside metabolic process), GO:0042455 (ribonucleoside biosynthetic process), GO:0042451 (purine nucleoside biosynthetic process), GO:0046128 (purine ribonucleoside metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process), GO:0046033 (AMP metabolic process), GO:0042451 (purine nucleoside biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process), GO:0046129 (purine ribonucleoside biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)