Protein: Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1) (O00212)
Organism: Homo sapiens (Human)
Function: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}.
Sequence: MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT
InterPro domains: - IPR001806: Small GTPase (family) [13-210]
- IPR003578: Small GTPase Rho (family) [17-192]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [13-200]
- IPR005225: Small GTP-binding domain (domain) [17-170]
Interaction partners: - Protein diaphanous homolog 2
- Plexin-A1
- Plexin-B2
- Plexin-B1
- Protein diaphanous homolog 1
- Rho-related GTP-binding protein Rho6
- Plexin-A4
- Plexin-A2
- Plexin-A3
- Rabankyrin-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:1902531 (regulation of intracellular signal transduction), GO:0007015 (actin filament organization), GO:0007010 (cytoskeleton organization), GO:0051056 (regulation of small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0030667 (secretory granule membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle)