Protein: Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Solute carrier family 4 member 9) (Q8K4V2)
Organism: Rattus norvegicus (Rat)
Function: Probable apical anion exchanger of the alpha-intercalated cells of kidney. May participate in HCO3(-) absorption.
Subcellular location: Basolateral cell membrane {ECO:0000269|PubMed:12225984}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the basolateral membrane of both alpha-intercalated cells and beta-intercalated cells in the cortical collecting duct (CCD) kidney cells (PubMed:12225984). Localized in the basolateral membrane of the submandibular gland (SMG) duct (By similarity). {ECO:0000250|UniProtKB:A0A494BA31, ECO:0000269|PubMed:12225984}.
Sequence: MKLPGQEDFEGSDAHENVCSEQLDGDLGPGSGLDGPSDIDNGKAQGCKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDIGAGRWSAPHVPTLALPSLQKLRGLLAEGIVLLDCPARSLLELVEQVVRVESLSPELRGQLQALLLQRPQHHIQTTGIRPCRRSNAFRKASRDEDTLLKHQNPLRQKLPPGAEAAAVLAGELGFLEQPLAAFVRLQNPVVLEPLTEVVLPSRFFCLLLGPSTLGRSYHETGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLQEVTALPPGRWDRTARIPPPKCLPSQHKRFPSKLQEVTSLSRQSAALAENKHHHGPHTPIPELQRTGRLFGGLVQDVRRKACWYPSDFLDALHPQCFSAVLYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGATFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLIRAYPIQRPGSPAYSCFCQYPGTGGNASEFDSTMFKDTEDVLNVHPGLVNASFLPPSECIRQGGYPRGPSCHTVPDIAFFSLLLFFTSFLCAIALKHVKNSRLFPSVVRKVFSDFSSVLAILLGCGLDAFLGLATPKLLVPTEFKPTLPGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHMDSLRRESKACVPGEDPNFLGIREQRLTGLVVFILTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSMQFMKRVQLLLMPRKHQPDVLLLRHVPLIRVHLFTAIQLACLGLLWVIKSTPAAIVFPLMLLGLVAVRKALEWIFSPQELLWLDELMPEEEKTIPENRPEPEHLFSGNDSENSELMYQPKAPEINISVN
InterPro domains: - IPR013769: Band 3 cytoplasmic domain (domain) [52-298]
- IPR011531: Bicarbonate transporter-like, transmembrane domain (domain) [354-912]
- IPR003020: Bicarbonate transporter, eukaryotic (family) [52-917]
- IPR016152: Phosphotransferase/anion transporter (homologous_superfamily) [47-324]
- IPR003024: Sodium bicarbonate cotransporter (family) [240-490]
Interaction partners: - Carbonic anhydrase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015106 (bicarbonate transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0140410 (solute:bicarbonate symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0019755 (one-carbon compound transport), GO:0015711 (organic anion transport), GO:0015701 (bicarbonate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0045177 (apical part of cell)