Protein: Double C2-like domain-containing protein gamma (Doc2-gamma) (Q9ESN1)
Organism: Mus musculus (Mouse)
Function: May be involved in regulation of vesicular trafficking. In vitro, does not bind calcium and phospholipids.
Sequence: MACAGPASGRHGVSMQEHMAIDVSPGPIRPIRLISNYFPHFYPFLEPVLRAPDRQAMLAPAIPSAPQLQPNPEPEGDSDDSTALGTLEFTLLFDEDNSALHCTAHRAKGLKPPAAGSVDTYVKANLLPGASKASQLRTRTVRGTREPVWEETLTYHGFTCQDAGRKTLRLCVCEDSRLRRRRRGPPLGELRVPLRKLVPNRARSFDICLEKRKLTKRPKSLDTARGMSLYEEEEVEAEVFGEERGRILLSLCYSSERGGLLVGVLRCVHLAPMDANGYSDPFVRLFLHPSSGKKSKYKTSVRRKTLNPEFNEEFFYAGHREELAQKALLVSVWDYDLGTADDFIGGVQLSGRASGERLRHWRECLGHCDHRLELWHLLDSVPPQLGD
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [75-381]
- IPR000008: C2 domain (domain) [83-376]
- IPR014638: Double C2 protein, alpha/beta/gamma (family) [2-387]
- IPR043566: Rabphilin/Doc2/Noc2 (family) [24-380]
- IPR001565: Synaptotagmin (domain) [247-349]
- IPR047022: Rabphilin/Doc2, first C2 domain (domain) [84-209]
Interaction partners: - Rab effector Noc2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0005543 (phospholipid binding), GO:0005544 (calcium-dependent phospholipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0051050 (positive regulation of transport), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051649 (establishment of localization in cell), GO:0001505 (regulation of neurotransmitter levels), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0099536 (synaptic signaling), GO:0006810 (transport), GO:0032940 (secretion by cell), GO:0051128 (regulation of cellular component organization), GO:0031340 (positive regulation of vesicle fusion), GO:0023061 (signal release), GO:0031338 (regulation of vesicle fusion), GO:0017157 (regulation of exocytosis), GO:0046903 (secretion), GO:0006836 (neurotransmitter transport), GO:0099504 (synaptic vesicle cycle), GO:0006887 (exocytosis), GO:0099643 (signal release from synapse), GO:0099537 (trans-synaptic signaling), GO:0033043 (regulation of organelle organization), GO:1901632 (regulation of synaptic vesicle membrane organization), GO:0051046 (regulation of secretion), GO:0007269 (neurotransmitter secretion), GO:0016192 (vesicle-mediated transport), GO:0010638 (positive regulation of organelle organization), GO:0016079 (synaptic vesicle exocytosis), GO:0098916 (anterograde trans-synaptic signaling), GO:0099003 (vesicle-mediated transport in synapse), GO:0031630 (regulation of synaptic vesicle fusion to presynaptic active zone membrane), GO:0045055 (regulated exocytosis), GO:1903305 (regulation of regulated secretory pathway), GO:0007268 (chemical synaptic transmission), GO:0017158 (regulation of calcium ion-dependent exocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)