Protein: Vacuolar fusion protein mon1 (Q10150)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
Subcellular location: Endosome, multivesicular body membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Prevacuolar compartment membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Sequence: MEPTSEHSSIKEEVENDNVHRSHESECGSLLLNPGNVLMAAPSVSEDDQEVSRSTPELRSHVENVEQLLSDILHDNSSPLNVSTSVSSSSNNTAVDEIIKLLSLISFDLAKQKRTYLIFSSSGKPVFSNIVDDSIEPSTVGALQAIISSFEVSKEELTSFSTFSNVIVVLSKNPLYLVGVSPSTTLSAAYLLSELNLLYCQILTGVTAKAMQLTLNSRPNFDLRRLIGSNEQFLKELCDQLNDYELVPTLNAISPLPLRSSFRDQLSQLLLRETPKSLLFTFIAIRGRLVCMVKAKKLLLHANDLYLLFLSLFRTQSFNDSMEHWVPVCFPTLNPDAYIYIYSYFLCKDTVLIMGSSESGVFFEMQSVKCKVAQEIQDHGWLKKLIYCEEMDRTTPRNPGSPCISHYLFYSKKYSQFYTPGYSFSTPNFNTRTLYAIYASLHDQAFHKKNSFSINMTVHESLLLFTWSTASFDFHCIANATTSSQLLIANVNKILRWIRREENRLFIQTNLSF
InterPro domains: - IPR043972: FUZ/MON1/HPS1, first Longin domain (domain) [115-237]
- IPR043971: FUZ/MON1/HPS1, second Longin domain (domain) [276-374]
- IPR004353: Vacuolar fusion protein Mon1 (family) [29-513]
- IPR043970: FUZ/MON1/HPS1, third Longin domain (domain) [404-502]
Interaction partners: - Vacuolar protein sorting-associated protein 41
- Ypt/Rab-type GTPase ypt7
- Vacuolar morphogenesis protein 6
- Vacuolar protein sorting-associated protein 3
- Vacuolar membrane protein pep3
- E3 ubiquitin-protein ligase pep5
- GTP-binding protein ypt2
- Probable vacuolar protein sorting-associated protein 16 homolog
- Nuclear control of ATPase protein 2
- Inclusion body clearance protein IML2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0016050 (vesicle organization), GO:0032509 (endosome transport via multivesicular body sorting pathway), GO:0007033 (vacuole organization), GO:0071985 (multivesicular body sorting pathway), GO:0045324 (late endosome to vacuole transport), GO:0032511 (late endosome to vacuole transport via multivesicular body sorting pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005770 (late endosome), GO:0097708 (intracellular vesicle)