wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: (-)-5-epieremophilene synthase STPS1 (EC 4.2.3.199) (Sesquiterpene synthase 1) (SmSTPS1) (A0A1W6GW32)
Organism: Salvia miltiorrhiza (Chinese sage)
Function: Sesquiterpene synthase that catalyzes the conversion of farnesyl diphosphate to (-)-5-epi-eremophilene.
Sequence: MATTQAQIQRPIANFSPSLWGDQFIKNDPGAKAAEKHCKAVEELKKEVMNMITAAGSNLVEAMNLIDTLERLGISYHFEKEIDQKLKHFFNLNKDYSDESYDLYTVSLHFRLFRQHGHRISSDIFGRWIDESGKFKEGLKTDGKGLLSLYEASYLRTRGETILDDALEFATATLNSIAPHLESPLSKQVVHALIQPLHYGNPRIEAHNFISIYEENQDKNEFLLRFAKLDYNLLQMLHKEELNEVSRWWKELDLVSKLPYARDRVVECFFWAMGVYHEPQYSRARIMLTKTITMTSIIDDTYDAYGVIEELDIFTEAIERWNMEEMKKLPEYIQPFYKALLELYEQFEEELAEEGRSYAAHYAIESLKELVRSYHVEAKWFIQGYLPPFEEYLKNALITCTYCYHTTTSLLGVESAVEEDFEWLANKPKMLVAGLLICRVIDDIATYEVEKERGQSATGIESYMRDNNATIEEAVAKFFEIATDAWKDINEECLMPSPYSRDVLMRILNLERIIDVTYKGNEDGYTQPEKVLKPHIIALFVDPIKM
InterPro domains: - IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [17-218]
- IPR005630: Terpene synthase, metal-binding domain (domain) [250-488]
- IPR001906: Terpene synthase, N-terminal domain (domain) [19-193]
- IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [17-545]
- IPR034741: Terpene cyclase-like 1, C-terminal domain (domain) [219-545]
- IPR050148: Terpene synthase-like (family) [8-544]
- IPR044814: Terpene cyclases, class 1, plant (family) [10-543]
- IPR036965: Terpene synthase, N-terminal domain superfamily (homologous_superfamily) [57-219]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016838 (carbon-oxygen lyase activity, acting on phosphates), GO:0010333 (terpene synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006721 (terpenoid metabolic process), GO:0016114 (terpenoid biosynthetic process), GO:0006714 (sesquiterpenoid metabolic process), GO:0016106 (sesquiterpenoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Peptidoglycan endopeptidase RipA (EC 3.4.-.-) (Resuscitation-promoting factor interaction partner A) (Rpf-interacting protein A) (A0QX22)
Organism: Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
Function: Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan. Required for normal separation of daughter cells after cell division and for cell wall integrity (By similarity).
Subcellular location: Secreted. Note=Localizes to the septa. {ECO:0000250}.
Sequence: MRRTVRALATRVHGRVCAVPLVVGMLLATALYGGGPAAADPAAPDNLATLVAKVASADQKLQELGAAIQTQQETVNKAIVDVQAARDAAAAAQRELEAGQRGVADANAAIEAAQKRFDSFAAATYMNGPSRSYLTATDPADIVNTTATGQALIASSQQVMAKLQRARTEQVNRESAARLAKEKADQAARDAESSQDNAVAALKQAQQTFNAQQGELERLAAERAAAQAELDSVRKVSATGNAAPAAAPAAAPAPAAAPAPVPNSAPAPVPGAQPNPQAAAGNWDRAPSGPASSGQNWAVWDPTLPAIPSAFVSGDPIAIINAVLGIASTSAQVTADMGRSFLQKLGILPTPTGFTNGAIPRVYGREAVEYVIRRGMSQIGVPYSWGGGNAAGPSRGIDSGAGTVGFDCSGLMLYMFAGVGIKLDHYSGSQYNAGRKIPSSQMRRGDMIFYGPNASQHVAMYLGNGQMLEAPYTGSHVKVSPVRTSGMTPYVTRLIEY
InterPro domains: - IPR049836: Peptidoglycan endopeptidase RipA (family) [19-497]
- IPR051794: Peptidoglycan Endopeptidase C40 (family) [178-494]
- IPR000064: Endopeptidase, NLPC/P60 domain (domain) [365-497]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [365-483]
Interaction partners: - Resuscitation-promoting factor RpfB
- Penicillin-binding protein 1A
- Resuscitation-promoting factor
- Invasin 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0061783 (peptidoglycan muralytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008745 (N-acetylmuramoyl-L-alanine amidase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071554 (cell wall organization or biogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0030313 (cell envelope), GO:0009274 (peptidoglycan-based cell wall)
Protein: Terpene synthase 6 (EC 4.2.3.160) (Q54P86)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Terpene synthase that converts its substrate farnesyl diphosphate (FPP) into the sesquiterpene (2S,3R,6S,9S)-(-)-protoillud-7-ene.
Sequence: MSLSLGDIKFPDNWDLIPNEKNYIDYVYKESIELEVWRPNNKRDLMAHNNVVSLAKYFWPHVDFNRLVMGGELMVWFFSFDDVLDAGIYTDEKQMDLVKRMDNVFINGTVESDATGPEKMALHLRKKCEVMCGKRRKDTFNRFISSCVQWVDSIIPFNKLRSAQGTSPHLELYSYLRKVNIGAYPCVTLTEVMLDHEIEYYIWSDPKWIKMNEDIAIITTLINDLVSYEKEVNDQAGDLNPLYFLQNQKNIPLPDSYKQVVDLIDFWVKDYQTMEQSLLNEMEFKDSKQRSDMEFILEHLRYLASGSKKWSMQTPRYCSPTSPFIEMRTKPSTPVMNSTKKQKIDHVPSQSFISTPIDLNN
InterPro domains: - IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [7-350]
- IPR034686: Terpene cyclase-like 2 (family) [3-339]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016838 (carbon-oxygen lyase activity, acting on phosphates), GO:0010333 (terpene synthase activity), GO:0010334 (sesquiterpene synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0051761 (sesquiterpene metabolic process), GO:0046246 (terpene biosynthetic process), GO:0051762 (sesquiterpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Uncharacterized lyase C29B12.13 (EC 4.-.-.-) (O14034)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MPEYEGNCLCKAIHLKAIIEEPKLSCCHCETCRIWCSSPFMAFSCTQKPSVSENENVGKYASSSFAERIFCKNCGTTLYFAYTNGKNPYFINAWLFKGIENITFDAQVCIDDKPDCYDFANKTSMFTVDEVMKSIVK
InterPro domains: - IPR011057: Mss4-like superfamily (homologous_superfamily) [2-126]
- IPR006913: CENP-V/GFA domain (domain) [4-118]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016661 (oxidoreductase activity, acting on other nitrogenous compounds as donors)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044786 (cell cycle DNA replication), GO:0044248 (cellular catabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0034655 (nucleobase-containing compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0090304 (nucleic acid metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0033260 (nuclear DNA replication), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0006308 (DNA catabolic process), GO:0007005 (mitochondrion organization), GO:0016070 (RNA metabolic process), GO:0032042 (mitochondrial DNA metabolic process), GO:0006401 (RNA catabolic process), GO:0006261 (DNA-templated DNA replication), GO:0000002 (mitochondrial genome maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Phosphotyrosine protein phosphatase I domain-containing protein (Q38FI3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSTSSRGILIAGLTNRARTQMAEGILRRLTAGTIFIKSGGVHHESTIHPLAVKVMKDIGIDISKQSVTSLEAARRQQNTYDVYISIDCSYERRTLDKSQPPRAEVRRRESFTVEYGDDGSGPRGGDDPVRYDPLLVPRTPSHWSVGVDATDVRRRWQIWSPRDPSIFHETSTRKFQDHLYEGEPLFMQLRQCPWRTQAKVSERWEMDEVAIRYPVERHSAHELRFVQAREQLLQRSFDLLTKLEKHYGERLLLDRALLEEFIS
InterPro domains: - IPR036196: Phosphotyrosine protein phosphatase I superfamily (homologous_superfamily) [7-112]
- IPR023485: Phosphotyrosine protein phosphatase I (domain) [6-138]
Interaction partners: - Acyl carrier protein
- Small ribosomal subunit protein mS29
- [acyl-carrier-protein] S-malonyltransferase
- Rhodanese domain-containing protein
- Metallo-beta-lactamase domain-containing protein
- Uncharacterized protein
- tRNA pseudouridine synthase A-like protein
- Translation initiation factor IF-2
- DNA photolyase, putative
- 30S Ribosomal protein S17, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0140053 (mitochondrial gene expression), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0000963 (mitochondrial RNA processing), GO:0016071 (mRNA metabolic process), GO:0000959 (mitochondrial RNA metabolic process), GO:0000375 (RNA splicing, via transesterification reactions), GO:0090615 (mitochondrial mRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)
Protein: Protein FAM110B (Q8TC76)
Organism: Homo sapiens (Human)
Function: May be involved in tumor progression.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17499476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17499476}.
Sequence: MPTETLQTGSMVKPVSPAGTFTSAVPLRILNKGPDYFRRQAEPNPKRLSAVERLEADKAKYVKSQEVINAKQEPVKPAVLAKPPVCPAAKRALGSPTLKVFGNHAKTESGVQRENLKLEILKNIINSSEGSSSGSGHKHSSRNWPPHRSEATDLHRHSFAESLKVYPTQGRRSPQEGGSHVGRRLLEQSAESFLHVSHSSSDIRKVTSVKPLKAIPCSSSAPPLPPKPKIAAIASMKSPEADPVEPACGVSRRPSLQRSKSDLSDRYFRVDADVERFFNYCGLDPEELENLGMENFARANSDIISLNFRSASMISSDCEQSQDSNSDLRNDDSANDRVPYGISAIERNARIIKWLYSIKQARESQKVSHV
InterPro domains: - IPR025739: Centrosome-associated, FAM110, N-terminal domain (domain) [14-118]
- IPR025741: Centrosome-associated, FAM110, C-terminal domain (domain) [253-361]
- IPR025740: FAM110 (family) [1-370]
Interaction partners: - Centrosome and spindle pole-associated protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0043014 (alpha-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0007051 (spindle organization), GO:1903047 (mitotic cell cycle process), GO:0006996 (organelle organization), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0007052 (mitotic spindle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0000922 (spindle pole), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005819 (spindle), GO:0005634 (nucleus), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0005876 (spindle microtubule)
Protein: Iron-sulfur cluster assembly protein SufB (PfSufB) (Q25799)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MIKLKNFLNIYNLNYKYQYKNKINLYLIRQGLNINLIKNLSSNIFLYMFIYNFKKYSLKLLNIFKLPDWNFFDCPNINYDNIIYYSSILKDNNLIYYLKNNLNIEFLDSILIKNNSIDIIFDSMSILHTTQYFLKKLGIIFLPLFDIIFKYPLLIKKYLGTIISYKDNFFANINSIIFSEGSFCYIPKYVKCNFNLSTYFKTNSSDFAQFERTLIIVGKYSYVSYLEGCTASLYKESQLHVAIVEIIVKDYGYIKYYTLQNWYRGDYLGNGGLYNFTTKRGICLNYSKLDWIQVEVGSIITWKYPSTILKGKFSISNFYSISFISNMQIADTGSKMYHIGSYTKSYIISKSISLNNSLNIFRGLVYIKPFSYKSYNYTECSSLIFGNNSLTVTIPYIKNYNNTSYVKQEAFVSKIEIIYLFLLMQRGLSISESISLLIIGFCSDIYNKLPFEFNLEIPILFSLKIKDIFN
InterPro domains: - IPR037284: SUF system FeS cluster assembly, SufBD superfamily (homologous_superfamily) [40-456]
- IPR010231: SUF system FeS cluster assembly, SufB (family) [14-457]
- IPR055346: SUF system FeS cluster assembly, SufBD (family) [13-468]
- IPR000825: SUF system FeS cluster assembly, SufBD core domain (domain) [201-441]
Interaction partners: - Iron-sulfur cluster assembly protein IscU
- Iron-sulfur cluster assembly protein SufC
- Elongation factor Tu, apicoplast
- Cysteine desulfurase SufS
- DNA-directed RNA polymerase subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0051540 (metal cluster binding), GO:0005515 (protein binding), GO:0051536 (iron-sulfur cluster binding), GO:0051537 (2 iron, 2 sulfur cluster binding), GO:0051539 (4 iron, 4 sulfur cluster binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0022607 (cellular component assembly), GO:0016226 (iron-sulfur cluster assembly), GO:0031163 (metallo-sulfur cluster assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Thioredoxin reductase, putative (AFU_orthologue AFUA_5G03540) (Q5AU12)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MLLSRLLPLALSLAGTTLSAVIPETDYDVIVVGGGPAGLSVLSGLARVRRKAVVFDSGHYRNDPTREMHDVIGNDGTPPAVFRAAARSQISNYSTASFIDNEITSIVPVNNTNLTTFFRATDSTGAEYTARKVVLATGVVDILPSTPGLIEGFGKGIFWCPWCDGYEHRDQPFGILGTLPHIVSSVLEISTLNSDIIAFVNGSYTDEYVSALEEDYPDWQAQMAAYNVSIDNRTITSFERMQDGGENRNDVGQQFDIFRVHFTEGEPVVRNAFLTNFETAQRSSLPYDLGLVMKDGKIDTSINPGMRTSRAGVFAVGDANSDGSTNVPHAMFSGKRAAVFGHVELAREEMAAAISKRSLSTRALHKEAERAMGNELETLWEKVNA
InterPro domains: - IPR050097: Ferredoxin--NADP reductase type 2 (family) [25-345]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [23-339]
- IPR023753: FAD/NAD(P)-binding domain (domain) [27-172]
Interaction partners: - 2-oxoisovalerate dehydrogenase subunit alpha
- 2-oxoglutarate dehydrogenase, mitochondrial
- Thioredoxin, putative
- Thioredoxin
- Pyruvate dehydrogenase E1 component subunit beta
- 3-methyl-2-oxobutanoate dehydrogenase
- Flavoprotein, putative
- Probable mitochondrial E3-binding protein of the pyruvate dehydrogenase complex
- dihydrolipoyllysine-residue succinyltransferase
- Acetyltransferase component of pyruvate dehydrogenase complex
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0016670 (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0009404 (toxin metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009403 (toxin biosynthetic process), GO:0045460 (sterigmatocystin metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0045461 (sterigmatocystin biosynthetic process), GO:1901378 (organic heteropentacyclic compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Glutathione S-transferase (EC 2.5.1.18) (A0A140VJK4)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [4-80]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [81-220]
- IPR003080: Glutathione S-transferase, alpha class (family) [15-209]
- IPR050213: Glutathione S-transferase superfamily (family) [5-202]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [100-192]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [85-207]
- IPR040079: Glutathione transferase family (family) [5-203]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [3-83]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0060429 (epithelium development), GO:0030855 (epithelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)