Protein: Acetylcholine receptor subunit beta-type acr-2 (P48182)
Organism: Caenorhabditis elegans
Function: Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q23022}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q23022}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MKKTVKILLILITVFLKVHCNGGHDDEAADFLSHTNIDDPNNSSDPNKNSDQGDTMGEDEDRLVIDLFREYNFLIRPVKNVSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLAWNPAEYGNISNLHVPSDRVWLPDIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRIDVEWFPFDEQCCTLVFGSWTYNSEEVRLHWYNNIQAVQLHDYSYSGIWDVIDVPGQLVHKPDLKENKMVFNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTISLLLALVVFLLLVSKILPPTSNIPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALSHKMPTWVRKVFLEFLPHLLVMKRPERIPIFNGYFVEEYCASEIFDASLVMPSMTATMLPFLQVTTNLKAASSTSSGQSSEHHENCSKWKKRLSIRMSKRRAPRARLDDDSEDIIDDTNGNHVDSLQEKISKEMKTTVEAIAYIAEHMKREMSLKKMRDDWKYVAMVLDRLILLIFFGVTLGGTLGIICSAPHVFDFVDQEAIISKLNAKYLPSDMYS
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [271-557]
- IPR006201: Neurotransmitter-gated ion-channel (family) [53-545]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [47-270]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [185-199]
- IPR002394: Nicotinic acetylcholine receptor (family) [95-183]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [265-553]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [272-544]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [60-265]
Interaction partners: - Vesicular acetylcholine transporter unc-17
- Acetylcholine receptor subunit alpha-type unc-38
- Acetylcholine receptor subunit alpha-type unc-63
- Vesicular GABA transporter
- Acetylcholine receptor subunit beta-type acr-3
- AcetylCholine Receptor
- Glutamate decarboxylase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0060089 (molecular transducer activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022848 (acetylcholine-gated monoatomic cation-selective channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098739 (import across plasma membrane), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0099587 (inorganic ion import across plasma membrane), GO:0006811 (monoatomic ion transport), GO:0070588 (calcium ion transmembrane transport), GO:0098659 (inorganic cation import across plasma membrane), GO:0006816 (calcium ion transport), GO:0006812 (monoatomic cation transport), GO:0098703 (calcium ion import across plasma membrane), GO:0097553 (calcium ion transmembrane import into cytosol), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0005886 (plasma membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0043005 (neuron projection), GO:0097060 (synaptic membrane)