Protein: Kinesin light chain 2 (KLC 2) (O88448)
Organism: Mus musculus (Mouse)
Function: Kinesin is a microtubule-associated force-producing protein that plays a role in organelle transport. The light chain functions in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Through binding with PLEKHM2 and ARL8B, recruits kinesin-1 to lysosomes and hence direct lysosomes movement toward microtubule plus ends.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9H0B6}. Lysosome membrane {ECO:0000250|UniProtKB:Q9H0B6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H0B6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0B6}.
Sequence: MATMVLPREEKLSQDEIVLGTKAVIQGLETLRGEHRALLAPLASHEAGEAEPGSQERCLLLRRSLEAIELGLGEAQVILALSSHLGAVESEKQKLRAQVRRLVQENQWLREELAGTQQKLQRSEQAVAQLEEEKQHLLFMSQIRKLDEMLPQEEKGDVPKDSLDDLFPNEDEQSPAPSPGGGDVAAQHGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGENKPIWMHAEEREESKDKRRDRRPMEYGSWYKACKVDSPTVNTTLRTLGALYRPEGKLEAAHTLEDCASRSRKQGLDPASQTKVVELLKDGSGRGHRRGSRDVAGPQSESDLEESGPAAEWSGDGSGSLRRSGSFGKLRDALRRSSEMLVRKLQGGGPQEPNSRMKRASSLNFLNKSVEEPVQPGGRVFLTAAL
InterPro domains: - IPR002151: Kinesin light chain (family) [1-589]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [178-480]
- IPR019734: Tetratricopeptide repeat (repeat) [239-398]
- IPR015792: Kinesin light chain repeat (repeat) [264-305]
Interaction partners: - Kinesin-1 heavy chain
- Kinesin heavy chain isoform 5A
- Kinesin heavy chain isoform 5C
- Calsyntenin-1
- C-Jun-amino-terminal kinase-interacting protein 3
- Kinesin light chain 1
- Kinesin light chain 3
- Kinesin light chain 4
- Huntingtin-associated protein 1
- Glycogen synthase kinase-3 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0031503 (protein-containing complex localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0097722 (sperm motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0120316 (sperm flagellum assembly), GO:0051649 (establishment of localization in cell), GO:0030317 (flagellated sperm motility), GO:0007283 (spermatogenesis), GO:0042073 (intraciliary transport), GO:0007018 (microtubule-based movement), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0016043 (cellular component organization), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0003341 (cilium movement), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0007286 (spermatid development), GO:0099111 (microtubule-based transport), GO:0022607 (cellular component assembly), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0008088 (axo-dendritic transport), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060294 (cilium movement involved in cell motility), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0044458 (motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:1990351 (transporter complex), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0098797 (plasma membrane protein complex), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:1902495 (transmembrane transporter complex), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0034702 (ion channel complex), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0031982 (vesicle), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane), GO:0097708 (intracellular vesicle), GO:0008328 (ionotropic glutamate receptor complex), GO:0030424 (axon), GO:0044309 (neuron spine), GO:0032281 (AMPA glutamate receptor complex)