Protein: Phosphomannomutase (AtPMM) (EC 5.4.2.8) (O80840)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the interconversion of mannose-6-phosphate to mannose-1-phosphate, the precursor for the synthesis of GDP-mannose. GDP-mannose is an essential sugar nucleotide for the synthesis of D-mannose-containing cell wall polysaccharides (galactomannans and glucomannans), glycolipids, glycoproteins and the antioxidant L-ascorbate (Probable). Can complement the yeast temperature-sensitive mutant sec53-6.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0A0U1WZ18}.
Sequence: MAAKIPGVIALFDVDGTLTAPRKEATPELLDFIRELRKVVTIGVVGGSDLSKISEQLGKTVTNDYDYCFSENGLVAHKDGKSIGIQSLKLHLGDDKLKELINFTLHYIADLDIPIKRGTFIEFRNGMLNVSPIGRNCSQEERDEFERYDKVQNIRPKMVAELRERFAHLNLTFSIGGQISFDVFPKGWDKTYCLQYLEDFSEIHFFGDKTYEGGNDYEIYESPKTIGHSVTSPDDTVAKCKALFMS
InterPro domains: - IPR006379: HAD-superfamily hydrolase, subfamily IIB (family) [10-228]
- IPR005002: Phosphomannomutase (family) [6-245]
- IPR036412: HAD-like superfamily (homologous_superfamily) [10-243]
- IPR023214: HAD superfamily (homologous_superfamily) [9-240]
- IPR043169: Phosphomannomutase, cap domain (homologous_superfamily) [87-188]
Interaction partners: - Mannose-6-phosphate isomerase 1
- Mannose-1-phosphate guanylyltransferase 1
- Mannose-6-phosphate isomerase 2
- ADP-glucose pyrophosphorylase family protein
- ADP-glucose pyrophosphorylase family protein
- Probable mannose-1-phosphate guanylyltransferase 2
- Probable mannose-1-phosphate guanylyltransferase 3
- Hexokinase-like 1 protein
- Hexokinase-1
- Probable hexokinase-like 2 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0016868 (intramolecular transferase activity, phosphotransferases)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0001101 (response to acid chemical), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0009415 (response to water), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010033 (response to organic substance), GO:1901135 (carbohydrate derivative metabolic process), GO:1902074 (response to salt), GO:1901566 (organonitrogen compound biosynthetic process), GO:0046683 (response to organophosphorus), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009112 (nucleobase metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0009225 (nucleotide-sugar metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019673 (GDP-mannose metabolic process), GO:0009101 (glycoprotein biosynthetic process), GO:0009226 (nucleotide-sugar biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)