Protein: L-xylulose/3-keto-L-gulonate kinase (L-xylulokinase) (EC 2.7.1.-) (EC 2.7.1.53) (3-dehydro-L-gulonate kinase) (P37677)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the phosphorylation of L-xylulose and 3-keto-L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate.
Sequence: MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRALLTHSGVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAALTGLKAGTPVVGGLFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYHNFSEAQRDLRHPVRTLLPDMTAHQLYQKKYQRYQHLIAALQGFHARIKEHTL
InterPro domains: - IPR000577: Carbohydrate kinase, FGGY (family) [2-495]
- IPR018484: Carbohydrate kinase FGGY, N-terminal (domain) [4-250]
- IPR018483: Carbohydrate kinase, FGGY, conserved site (conserved_site) [354-374]
- IPR050406: FGGY Carbohydrate Kinase (family) [1-487]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [4-488]
- IPR018485: Carbohydrate kinase FGGY, C-terminal (domain) [259-440]
Interaction partners: - Putative L-ribulose-5-phosphate 3-epimerase SgbU
- 3-keto-L-gulonate-6-phosphate decarboxylase SgbH
- 2,3-diketo-L-gulonate reductase
- L-ribulose-5-phosphate 3-epimerase UlaE
- L-ribulose-5-phosphate 4-epimerase SgbE
- 3-keto-L-gulonate-6-phosphate decarboxylase UlaD
- L-Rhamnulokinase
- 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM
- 2,3-diketo-L-gulonate-binding periplasmic protein YiaO
- Probable L-ascorbate-6-phosphate lactonase UlaG
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0019200 (carbohydrate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0031667 (response to nutrient levels), GO:0019693 (ribose phosphate metabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0046434 (organophosphate catabolic process), GO:0009261 (ribonucleotide catabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0072523 (purine-containing compound catabolic process), GO:1901292 (nucleoside phosphate catabolic process), GO:0009117 (nucleotide metabolic process), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0034034 (purine nucleoside bisphosphate catabolic process), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0009166 (nucleotide catabolic process), GO:0006195 (purine nucleotide catabolic process), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0046031 (ADP metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)