Protein: Rap1 GTPase-GDP dissociation stimulator 1-A (Rap1gds1-A protein) (RalB-binding protein A) (XsmgGDS-A) (smgGDS-A) (O93614)
Organism: Xenopus laevis (African clawed frog)
Function: Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52306}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P52306}. Mitochondrion {ECO:0000250|UniProtKB:P52306}.
Sequence: MDNLNDALEKLKLTGTECTSDKLDGCFDCLLQALGHNNTESSEKIQQSGILQLFASILNSQSSCASKVAHIVAEIAKNELMRIPCVEAGLIPPLVQLLHSKDQEVLLQTGRALGNICYDNHEGRRAVDQEGGAQIVVDHLRSMCTLTDPSSEKLMTVFCGMLMNYSSENDSLQTQLIQMGVIPILVDLLGVHSQNTALTEMCLVAFGNLAELESSKEQFAGTNIAEEIVKLFKKQTEHEKREIIFEVLAPLAENDAIKMQLVEAGLVECLLDVVQQTVNSEKDDDIAELKTSSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWLPSNNHQLQLAGALAIANFARNDGNCIHMVDSEIVQKLLDLLDRHVEDGNVTVQHAALSALRNLAIPVVNKAKMLSAGVAEEVLKFLRSEMPPVQFKLLGTLRMLIDAQAEAAEQIGKNEKLAERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKDVIRTIVQSGGIKHLVTMATSEHVIMQNEALVALGLIAALELQAAEHDLESAKLVEVLHRLLLDERSAPEIKYNSMVLICAAMGSVPLHKEVQKLAFLDVVSKLRSHENKTVAQQASLTEQKLTVQS
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [66-596]
- IPR040144: Rap1 GTPase-GDP dissociation stimulator 1 (family) [1-605]
- IPR011989: Armadillo-like helical (homologous_superfamily) [27-606]
- IPR000225: Armadillo (repeat) [78-519]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0003013 (circulatory system process), GO:0090066 (regulation of anatomical structure size), GO:0003018 (vascular process in circulatory system), GO:0031033 (myosin filament organization), GO:0035150 (regulation of tube size), GO:0008015 (blood circulation), GO:0051336 (regulation of hydrolase activity), GO:0006936 (muscle contraction), GO:0043933 (protein-containing complex organization), GO:0043085 (positive regulation of catalytic activity), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0043087 (regulation of GTPase activity), GO:0097746 (blood vessel diameter maintenance), GO:0035296 (regulation of tube diameter), GO:0031034 (myosin filament assembly), GO:0065003 (protein-containing complex assembly), GO:0051345 (positive regulation of hydrolase activity), GO:0006939 (smooth muscle contraction), GO:0042310 (vasoconstriction), GO:0014829 (vascular associated smooth muscle contraction), GO:0043547 (positive regulation of GTPase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)