wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Kalirin RhoGEF kinase b (EC 2.7.11.1) (Zgc:136817) (Q1RLV0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MEIIKDPSAQEDKTPERGSFPVLGSDTPSDQTPRDPETEQKNKALRGRMFVLNEMVQTERDYVKDLGVTVEGFMRRIGEKGVPEDMTGKDKIVFGNIHQIYDWHKEFFLCELEKCLQDHDKLAELFIKHERRLHMYVIYCQNKPRSEFVVAEYDKYFEGVQQEINSRLAISDYLIKPIQRITKYQLLLKDFLKYSTKAGLDCKEIEKAVELMSLVPKQCNDMMNLGRLQGYEGKLTAQGKLLQQDTFFVTEQDSGVLSRSKERRVFLFEQIVIFSELLRKGSSTPGYQFKKSIKVSYLSMEEQVESDPYKFVLLCRGSSERLTLQAANVDIKKEWVQSIRELLDMQINFLTALQNPQAALTSQLSNSNRSSSSQPSTPLKPNTAPNGSPAQKNNKHAEEDLDEGECNGLSSVLVTQDYNAVKEDEICVVVGEKVQIMASNQQNMCLVYRPANSQSPAAEGWVPGHVLSSTR
InterPro domains: - IPR000219: Dbl homology domain (domain) [47-222]
- IPR001849: Pleckstrin homology domain (domain) [234-346]
- IPR051336: Rho GTPase-activating Guanine Nucleotide Exchange Factors (family) [12-469]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [408-468]
- IPR001452: SH3 domain (domain) [407-471]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [235-341]
- IPR047053: Kalirin/Triple functional domain protein, SH3 domain 2 (domain) [402-469]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [31-238]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [239-377]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0032153 (cell division site), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0098590 (plasma membrane region), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0032154 (cleavage furrow), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Esculentin-2Ra (P86017)
Organism: Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
Function: Antimicrobial peptide.
Subcellular location: Secreted {ECO:0000269|PubMed:18855342}.
Sequence: GILSLVKGAAKLLGKGLAKEGGKVGLEFIACKVTNQC
InterPro domains: - IPR012521: Frog antimicrobial peptide, brevinin-2/esculentin type (domain) [1-37]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0001906 (cell killing), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0031640 (killing of cells of another organism), GO:0019835 (cytolysis), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0051715 (cytolysis in another organism), GO:0009620 (response to fungus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0044179 (hemolysis in another organism), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Methionine import ATP-binding protein MetN (EC 7.4.2.11) (P30750)
Organism: Escherichia coli (strain K12)
Function: Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. It has also been shown to be involved in formyl-L-methionine transport.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01719, ECO:0000305}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01719, ECO:0000305}.
Sequence: MIKLSNITKVFHQGTRTIQALNNVSLHVPAGQIYGVIGASGAGKSTLIRCVNLLERPTEGSVLVDGQELTTLSESELTKARRQIGMIFQHFNLLSSRTVFGNVALPLELDNTPKDEVKRRVTELLSLVGLGDKHDSYPSNLSGGQKQRVAIARALASNPKVLLCDEATSALDPATTRSILELLKDINRRLGLTILLITHEMDVVKRICDCVAVISNGELIEQDTVSEVFSHPKTPLAQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEVLGYV
InterPro domains: - IPR018449: NIL domain (domain) [265-340]
- IPR041701: Methionine import ATP-binding protein MetN, ATP-binding domain (domain) [1-233]
- IPR012692: ABC transporter, methionine import, ATP-binding protein MetN, proteobacteria (family) [1-343]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [141-155]
- IPR003593: AAA+ ATPase domain (domain) [30-218]
- IPR050086: Methionine import ATP-binding protein MetN-like (family) [1-253]
- IPR045865: ACT-like domain (homologous_superfamily) [248-343]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-240]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [2-241]
Interaction partners: - D-methionine-binding lipoprotein MetQ
- D-methionine transport system permease protein MetI
- Lipoprotein 28
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydD
- Vitamin B12 import system permease protein BtuC
- Vitamin B12 import ATP-binding protein BtuD
- ATP-dependent lipid A-core flippase
- Putrescine transport ATP-binding protein PotG
- sn-glycerol-3-phosphate transport system permease protein UgpA
- Maltose/maltodextrin import ATP-binding protein MalK
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Putative magnesium transporter YhiD (P0AFV2)
Organism: Escherichia coli (strain K12)
Function: Could be involved in magnesium uptake.
Subcellular location: Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MTAEFIIRLILAAIACGAIGMERQMRGKGAGLRTHVLIGMGSALFMIVSKYGFADVLSLDHVGLDPSRIAAQVVTGVGFIGAGNILVRNQNIVGLTTAADIWVTAAIGMVIGSGMYELGIYGSVMTLLVLEVFHQLTFRLMNKNYHLQLTLVNGNTVSMLDWFKQQKIKTDLVSLQENEDHEVVAIDIQLHATTSIEDLLRLLKGMAGVKGVSIS
InterPro domains: - IPR049177: MgtC/SapB/SrpB/YhiD, N-terminal domain (domain) [9-136]
- IPR003416: MgtC/SapB/SrpB/YhiD family (family) [3-197]
Interaction partners: - Protein HdeD
- Transcriptional regulator GadE
- HTH-type transcriptional regulator DctR
- Glutamate decarboxylase alpha
- Outer membrane protein Slp
- Acid stress chaperone HdeB
- Acid stress chaperone HdeA
- Multidrug resistance protein MdtE
- Glutamate decarboxylase beta
- Glutamate/gamma-aminobutyrate antiporter
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0005253 (monoatomic anion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: 1,4-beta-D-glucan cellobiohydrolase C (EC 3.2.1.91) (Beta-glucancellobiohydrolase C) (Exocellobiohydrolase C) (Exoglucanase C) (Q5B2E8)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. Active against carboxymethylcellulose, beta-glucan and lichenan.
Subcellular location: Secreted {ECO:0000250}.
Sequence: MHYSASGLALAFLLPAIQAQQTLYGQCGGSGWTGATSCVAGAACSTLNQWYAQCLPAATTTSTTLTTTTSSVTTTSNPGSTTTTSSVTVTATASGNPFSGYQLYVNPYYSSEVQSIAIPSLTGTLSSLAPAATAAAKVPSFVWLDVAAKVPTMATYLADIRSQNAAGANPPIAGQFVVYDLPDRDCAALASNGEFAISDGGVQHYKDYIDSIREILVEYSDVHVILVIEPDSLANLVTNLNVAKCANAQSAYLECTNYAVTQLNLPNVAMYLDAGHAGWLGWPANLQPAANLYAGVYSDAGSPAALRGLATNVANYNAWAIDTCPSYTQGNSVCDEKDYINALAPLLRAQGFDAHFITDTGRNGKQPTGQQAWGDWCNVIGTGFGARPSTNTGDSLLDAFVWVKPGGESDGTSDTSAARYDAHCGYSDALQPAPEAGTWFQAYFVQLLQNANPSF
InterPro domains: - IPR016288: 1, 4-beta cellobiohydrolase (family) [3-455]
- IPR001524: Glycoside hydrolase, family 6, conserved site (conserved_site) [177-234]
- IPR000254: Cellulose-binding domain (domain) [19-55]
- IPR036434: 1, 4-beta cellobiohydrolase superfamily (homologous_superfamily) [90-455]
- IPR035971: Cellulose-binding domain superfamily (homologous_superfamily) [21-55]
Interaction partners: - 1,4-beta-D-glucan cellobiohydrolase B
- Endo-beta-1,4-glucanase A
- Probable 1,4-beta-D-glucan cellobiohydrolase A
- Endo-beta-1,4-glucanase B
- Endo-beta-1,4-glucanase celB
- Extracellular endoglucanase, putative
- Glucanase
- beta-glucosidase
- Probable beta-glucosidase A
- Beta-glucosidase B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009056 (catabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0005976 (polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0044042 (glucan metabolic process), GO:0009251 (glucan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: MKIAA1413 protein (Q69ZK1)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: SHEYCQCQPDIENAMDCLLELSATDAKGAESSAQTSGDRDSKPGAAGNSVMETCHPEGEGEDSKLDSFLDMQLTEDLDSLIQNAFEKLNSPPDDQVYPFSPLQDANSFNDPSTFMNSDSSGMTSLLSVQSTSSNSETLKSSASLPGSNPPTSHSVLNAPESCAKLALEGGYSEGSPLSSSGNPTNGSVRGCGNFSQRQKDLSESECPSAQHSQALADLGNSDPQAPSTHPLHNSGSDLPGTDGDQKSASAPDVFVPSEGFNFKPHKHPELPPKGKDMNYCPVLTPLPLLLPPPPPPPIWNPMIPAFDLFQGNHGFVAPVVTTAAHWRPVNYTFPPPIISHNSPTKVWRGGEGASAYQVQEAPASQPVRKKATSFVGLVLVLLRGLPGSGKSFLARTLQEDNPGGVILSTDDYFYINGQYQFDVKYLGEAHEWNQNRAKEAFEKKVSPVIIDNTNLQAWEMKPYVALSQKHKYKVLFREPDTWWKFKPKELARRNIHGVSKEKISRMLEHYQRFVSVPIIMSSSDPEKTERIELCAYASDDSPRDSEAISSAKEDSVSSASPKHSELTEEKTLEVATQAVLSVRDPQLPCPGLNRGRKELGDVSHGGHNPFFQEAPSTYFPNPESKGQATDRSEEEQEMVSEKEHCEADAWRPAGGASSDGRCADDNQEACGSAGAAALPGETPSPPEMLEERTAGKKKTIGKQKGKSSLEKIPKQELSNFVGDWPVDKTISQRTKRNRKTEKGLSVQSDKKGNLPQSHKVLDARVSVNTDPVQPQGSSHGNDDLSEVPSSYHYDPYRSTEQSSLSAVSDWPSSASLAPREHRPRMPKADLSEPSVEFGTNDNLGEIPLYPAHEAYWGTSPEELKTLSSSLRSSEMLPSQTAPEHHPTSLNPLAHSQHALPLTFPSSAAALPGVVGPRSLTEFPVGVSGIVSGVDTGTCTQTEPQDFALLWKIEKNKINVSDSVRVLTGRLDGFKPKDFTLNRKVNVQETIPYRVMHDKSTFVEESELTSADESENLNILCKLFGSFSLEALKDLYERCNKDIIWATSLLLDSETKLCEDTAVESSPKSYSESQVGPFSMGLDLKEIISHRGTSEGSNSSVSEFSPGIGIRNTSARSAGNPGKGTSEQEGRRAMNPENPELITRVFPNAAVKVKSNNETLPDRQAELPGAYTFKQPLSLTPRSYIPKDVSEIEKNLVMTETRDNMHSFLNLSDIINSATSTSNPELNEDVYLTGSLEVKKNENLPKDYVKFANMEEFINEDKQEMEKNLMPGSGWSAGVSEEGKAEVLTPTPVTATSLTIDCLELALPPELAFQLNELFGPVGIDSGSLTVEDCVVHIDLNLAKVIHEKWRESVMERQRQEEVSRGKRTQDPLLAGHTGLDNFEQKSSQKTGKRLLKTLAAPETLDHWNTQTKKVSLREIMSEEIALQEKHDLKRETLMFEKDCATKLKEKQLFKIFPAINQNFLVDIFKDHSYSLENTVQFLNCVLEGDPVKTVVAQECVHQNENNTYTAQK
InterPro domains: - IPR056720: NEDD4-binding protein 2, DUF7818 (domain) [1296-1339]
- IPR052772: Endonuclease/Polynucleotide Kinase Domain-Containing Protein (family) [6-1509]
- IPR056719: NEDD4-binding protein 2, DUF7817 (domain) [937-978]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [378-518]
- IPR056718: NEDD4-binding protein 2, DUF7816 (domain) [1433-1503]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0045596 (negative regulation of cell differentiation), GO:0045661 (regulation of myoblast differentiation), GO:0045662 (negative regulation of myoblast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Diphthine--ammonia ligase (EC 6.3.1.14) (ATP-binding domain-containing protein 4) (Diphthamide synthase) (Diphthamide synthetase) (Protein DPH6 homolog) (Q7L8W6)
Organism: Homo sapiens (Human)
Function: Amidase that may catalyze the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).
Sequence: MRVAALISGGKDSCYNMMQCIAAGHQIVALANLRPAENQVGSDELDSYMYQTVGHHAIDLYAEAMALPLYRRTIRGRSLDTRQVYTKCEGDEVEDLYELLKLVKEKEEVEGISVGAILSDYQRIRVENVCKRLNLQPLAYLWQRNQEDLLREMISSNIQAMIIKVAALGLDPDKHLGKTLDQMEPYLIELSKKYGVHVCGEGGEYETFTLDCPLFKKKIIVDSSEVVIHSADAFAPVAYLRFLELHLEDKVSSVPDNYRTSNYIYNF
InterPro domains: - IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [1-159]
- IPR002761: Diphthamide synthase domain (domain) [1-235]
- IPR030662: Diphthine--ammonia ligase/Uncharacterised protein MJ0570 (family) [1-257]
Interaction partners: - Diphthine methyl ester synthase
- Elongation factor 2
- Diphthine methyltransferase
- 2-
- Diphthamide biosynthesis protein 3
- 2-
- DnaJ homolog subfamily C member 24
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0016881 (acid-amino acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:2000026 (regulation of multicellular organismal development), GO:0044085 (cellular component biogenesis), GO:0045596 (negative regulation of cell differentiation), GO:0030857 (negative regulation of epithelial cell differentiation), GO:0034330 (cell junction organization), GO:0022607 (cellular component assembly), GO:0007416 (synapse assembly), GO:0050808 (synapse organization), GO:0034329 (cell junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Leucine-rich repeat protein kinase family protein (F4IB63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MESHRVFVATFMLILHLVQAQDQPGFINVDCGLLPRDSPYNALGTGLVYTSDVGLVSSGKTGKIAKEFEENNSTPNLTLRYFPDGARNCYNLNVSRDTNYMIKATFVYGNYDGHKDEPNFDLYLGPNLWATVSRSETVEEIIHVTKSDSLQVCLAKTGDFIPFINILELRPLKKNVYVTESGSLKLLFRKYFSDSGQTIRYPDDIYDRVWHASFLENNWAQVSTTLGVNVTDNYDLSQDVMATGATPLNDSETLNITWNVEPPTTKVYSYMHFAELETLRANDTREFNVMLNGNDLFGPYSPIPLKTETETNLKPEECEDGACILQLVKTSKSTLPPLLNAIEAFTVIDFLQVETDEDDAAAIKNVQNAYGLINRSSWQGDPCVPKQYSWDGLKCSYSDSTPPIINFLDLSASGLTGIIAPAIQNLTHLEILALSNNNLTGEVPEFLADLKSIMVIDLRGNNLSGPVPASLLQKKGLMLHLDDNPHILCTTGSCMHKGEGEKKSIIVPVVASIVSLAVIIGALILFLVFRKKKASKVEGTLPSYMQASDGRSPRSSEPAIVTKNKRFTYSQVVIMTNNFQRILGKGGFGIVYHGFVNGVEQVAVKILSHSSSQGYKQFKAEVELLLRVHHKNLVGLVGYCDEGENMALIYEYMANGDLKEHMSGTRNRFILNWETRLKIVIDSAQGLEYLHNGCKPLMVHRDVKTTNILLNEHFEAKLADFGLSRSFPIGGETHVSTVVAGTPGYLDPEYYKTNRLTEKSDVYSFGIVLLEMITNRPVIDQSREKPYISEWVGIMLTKGDIISIMDPSLNGDYDSGSVWKAVELAMSCLNPSSTRRPTMSQVLIALNECLVSENSRGGASRDMDSKSSLEVSLTFDTDVSPMAR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [553-846]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [361-487]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [698-710]
- IPR024788: Malectin-like domain (domain) [29-347]
- IPR001611: Leucine-rich repeat (repeat) [408-463]
- IPR017441: Protein kinase, ATP binding site (binding_site) [583-605]
- IPR000719: Protein kinase domain (domain) [577-850]
Interaction partners: - Dormancy-associated protein homolog 1
- Wax ester synthase/diacylglycerol acyltransferase 4
- FCS-Like Zinc finger 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0055044 (symplast), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)
Protein: Probable plasma membrane ATPase (PAT2) (EC 7.1.2.1) (P-type H(+)-ATPase) (Proton pump) (P54679)
Organism: Dictyostelium discoideum (Social amoeba)
Function: P-type plasma membrane H+-ATPase (proton pump). The proton gradient it generates drives the active transport of nutrients by H(+) symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Subcellular location: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:9421912}.
Sequence: MDNNQIPKNSPESSAINSAESSPKSNVSSDVLHENHHKEQQQLQQQLQQEQQQQQLPTTPQSEPTQRVNNNEEGIEMDRIAENSNINVPSDVGESSLKTISGYPSSKNTEAGSSSSGKKEEDYNYRSTWVPKLHQELFENPEVLESRRTKQRASNYRKTLEREKEGIKPLDNILEELKANANGLTKAEAQKRLEEVGPNAIPDVKRYPILEFLYFMWNPLSWTMEVAAIVSIALLDWVDFILICALLLLNATIGFIEENTAGNAVEALKNSLVSQIRCMRDGEWVMLPSPDLVPGDVVMLKIGAIIPADCRVIEAEQVKIDQSSLTGESLPVTKKIGDEVYSGSAMKQGEAKCVVTATGVNTFFGRAANLVQETEGHGHLQVILRNIGLFCISFIAIWVLVELLVDFLGYDGYCHGVGGGRCLPLNNALVLLVGGIPIAMPTVLSVTMAIGATQLSKKKAIVSRLASIEELAAMDILCSDKTGTLTLNILTVDEPLPVGDTPKEDIVFHAFLACSEGEDQDAIDKAISNYCRDTYPNVDYSGNEIVKHYPFNPEDKKAMGLVNANGKQFKTAKGAPQIILREADNYKQVGEAVEKEIENLADRGYRALGVSVSYDAPDFKVWHFEGLIPLFDPPRHDTEDTIKRALEMGVSVKMITGDQLAIAKETARRLGMGGNLFTIPYLENNDLGISEGEVIEMADGFAEMWPEHKYKVVDQLQKRKHVVGMTGDGVNDAPALKKAQIGIAVAGATDAARSVSDIVLTSSGLSVIIDAIISSRKIFQRMRNYVIYSVAATVRICTTFGILTVAWNFKFPTIATVIIAILNDGTMLTISKDRVRARNEPDQWNLFEVFTMALCYGFYLVGSTIVFFAIIHDGTWFHDAINLRILTDNELRGLIYLQVSISGLATIFVSRSQGFSYFERPGNLVIFAFVMSQIVATFIGVYGFRGYPHDSFSDNPDYPVHGTNFQGCGWGWAVCAWIWCFLWYIPMDFIKLGVTYILRGKIEPINKDALRKIYGWFGKEIPKEATQVSHKVAEQQAKRDALHAQETHHKSVVTDNKV
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [276-371]
- IPR001757: P-type ATPase (family) [243-917]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [490-631]
- IPR036412: HAD-like superfamily (homologous_superfamily) [474-780]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [460-777]
- IPR006534: P-type ATPase, subfamily IIIA (family) [183-992]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [480-486]
- IPR023214: HAD superfamily (homologous_superfamily) [475-763]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [164-236]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [168-997]
Interaction partners: - Inorganic pyrophosphatase
- Vacuolar proton translocating ATPase 100 kDa subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0006972 (hyperosmotic response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)