Protein: Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein) (Q9WTJ6)
Organism: Mus musculus (Mouse)
Function: Essential for normal spermatogenesis and male fertility. Required for the completion of meiosis in male germ cells.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11803038, ECO:0000269|PubMed:12606435}. Nucleus {ECO:0000269|PubMed:11803038, ECO:0000269|PubMed:12606435}. Note=Predominantly localized to the cytoplasm (PubMed:11803038, PubMed:12606435). Translocates from the cytoplasm to the nucleus in the G2/M transition upon treatment with cadmium, cobalt or zinc (PubMed:11803038, PubMed:12606435). {ECO:0000269|PubMed:11803038, ECO:0000269|PubMed:12606435}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:31916570}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:31916570}.
Sequence: MEDALLGAMTGPEDELGAELFGSERVFADGLALSPAGGAADRDELPVLADAYLGATEPGEPLLRALSPPPGAEVPAALLGDFPGLPELRSPDDAAPPPAYSVHVLSSLLPGARGPALLPLSAGVRVIPVEIKEAGGSVPGGSPEDAAFQAPLAQESCCKFPSSQEAEEASSCPRKKDSSPMVICQLKGGAQMLCIDNCGARELKALHLLPQYDDQSSFPQSELPKPMTTLVGRLLPVPAKLNLITQVDNGALPSAVNGAAFPSGPALQGPPKITLSGYCDCFSSGDFCNSCSCNNLRHELERFKAIKACLDRNPEAFQPKMGKGRLGAAKLRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIACKNYEESPERKMLMSTPHYMEPGDFESSHYLSPAKFSGPPKLRKNRQAFSCISWEVVEATCACLLAQGEEAEQEHCSPSLAEQMILEEFGRCLSQILHIEFKSKGLKIE
InterPro domains: - IPR033467: Tesmin/TSO1-like CXC domain (domain) [332-373]
- IPR028307: Lin-54 family (family) [163-467]
- IPR005172: CRC domain (domain) [263-372]
Interaction partners: - Protein lin-52 homolog
- Protein lin-9 homolog
- Protein lin-37 homolog
- H/ACA ribonucleoprotein complex non-core subunit NAF1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009892 (negative regulation of metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007276 (gamete generation), GO:0009968 (negative regulation of signal transduction), GO:0007281 (germ cell development), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048515 (spermatid differentiation), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0007283 (spermatogenesis), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0033144 (negative regulation of intracellular steroid hormone receptor signaling pathway), GO:0048477 (oogenesis), GO:0030111 (regulation of Wnt signaling pathway), GO:0007286 (spermatid development), GO:0010468 (regulation of gene expression), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0048232 (male gamete generation), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)