Protein: Origin of replication complex subunit 6 (AtORC6) (Q9ZVH3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9Y5N6}.
Sequence: MDISDIGRKLSLDNNKLLIRKAAEIRRLCDAQFDSSIIGVGEICKAVICLEIAATRLQIIFDRQAAVKLSGMSEKAYSRSFNSLQNVIGIKIKLNVRELAVQFGCVRVIKSVQNVLSSYKERFLASLPASRRANADFTRPVFTAAAFYLCAKKQKLKVDKLRLIEVCGTSESEFSCVSTSMTDLCFDCVGISKEKKDAKDVKGNRDLLDVLPGKRRLEDGGYSSGDESSCYKRHKKMEEAKYEDWKSTVVNSIKKNPEKGTKRVIQASLNFPKKSETKELQVDS
InterPro domains: - IPR008721: ORC6, first cyclin-like domain (domain) [3-91]
- IPR054113: ORC6, second cyclin-like domain (domain) [94-184]
- IPR020529: Origin recognition complex, subunit 6, metazoa/plant (family) [1-274]
Interaction partners: - Origin of replication complex subunit 1A
- DNA replication licensing factor MCM7
- Origin of replication complex subunit 1B
- Origin of replication complex subunit 2
- Origin of replication complex subunit 5
- Origin of replication complex subunit 3
- Origin of replication complex subunit 4
- Cell division control protein 6 homolog
- DNA replication licensing factor MCM4
- Cell division control protein 6 homolog B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006260 (DNA replication), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0000808 (origin recognition complex), GO:0140513 (nuclear protein-containing complex), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0005664 (nuclear origin of replication recognition complex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)