Protein: Phospholipid-transporting ATPase (A0A1D8PMY6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
Sequence: MTKNKHNFTLNNSSDGVNNNDDPSDHHDYSDDSMPPTPTISTFNKFPRQSSLRFKTPLPNDTPRSSSSGSTSNNNNHNHNQKSPFLDENEASFDRKFGYNYDKDKVVEEEDENEDEATYVVGEDNEDNEDENDNINEMDPSNLKTKRHRWGTTRHKHGRPKNENINRSKTLKKILAPHKSKGKSHSKNSHSLNKRLLSIRKPNTHRVNFPHDNQPPPQDLDFEEQNDPKNRKSEKRTVTFNRPLPPHLVDPETNKPLTNYPRNKIRTTKYTPLSFFPKNIWNQFMHNVANIYFLVLIILGAFEIFGVPSPVLAAVPLIVIVIITAIKDAIEDSRRTVTDLEVNNQITHILTQVNEDAANGYHYENVNVDDEQVSYWRQFKKWNTRLLIRFWGASKRNLTKEGRANKIRERYNRENNIDGDGDQQQGRKSFDSDIVSNRTSFEQTENPFNDTLRQSFQQQRQQQQRQSSSYRHKTMKFAKKYWKDVKVGDVLRIYNNDEVPADLVILATSDEDNCCYVETKNLDGETNLKVKQALKYSSINEKIHKADDLINHDFEIDSEGPHANLYSYQGNLKYTNRMNNSQSYDNHEDSQEAITINNLLLRGCTLRNTKWAIGIVVFTGDDTKIMLNAGVTPTKQSRMSRELNYYVLLNFILLFVICFISGLVNGIYYRETNTSRDYFEFGTIASTPALNGLVGFFVSLILYQSLVPISLYITIEIIKTAQAFFIYSDVGMYYSKLDFPCTPKSWSISDDLGQIEYIFSDKTGTLTQNLMEFKKCTINGVSYGKAYTEALAGLRKRMGIDVEIEAAQERELISRDKEVMIEKLHTINKNKTYDDEITFVSSEFIDDLTDSSINNQQQRESNHHFMLALALCHSVMTEPDPKQPNKLMLKAQSPDEAALVGTARSLGFNFKGTTKTGVIVDVHGETKEYQVLNTLEFNSTRKRMSSIIKIPGEGPNDEPRALLICKGADSIIYERLSATENDPSMLEKTSKHLEEYATEGLRTLCIAERELSWKQYVEWNKRHQAAASSLDDREAKMEAVADSIERELTLLGGTAIEDRLQDGVPDAISILADAGIKLWVLTGDKVETAINIGFSCNLLGNDMQLLVIKTAYNDDENGSNDDNSSEDKNSLQGLKFGHNASEPEIVDTVISYYLRKHFDMTGSFEEKEAAVGDHSPPDERFGVVIDGDALKLVLLSPDVKRKFLLLCKKCRAVLCCRVSPAQKAAVVKLVKDTLNVMTLAIGDGSNDVAMIQAADVGVGIAGEEGRQAVMSSDYAIGQFRYLARLLLTHGRWSYKRFSEMIPSFFYKNIIFNIALFWYGIYCDFDGTYLFEFTYLMFYNLAFTSLPVIFLGIFDQDVEAKVSLLVPQIYRTGITRTEMSDLKFYLYCLDGIYQSAISYFFPYLLYMVAFPNMNGKPVDHRFWMGVLVTCIACISCNCYILFHQFRWDWLSSLIVAISILIIFIWTGLWTVNYQSSGEFYKAAPEIFGMTAFWACMFVGILCCLIPRFFYDFVMRIFWPKDIDIIRECVARGDFEAYPFDYDPTDPNRPKISTYSSDVVHRMSMNYPSPPQTQATSTDSNGKSPSSSSLDNGHQSRNSNNLNGNGYYDQDNSSGSNLTYDRSIIFERVNESPINAHHQQPPTPPPGIIASPIRKRKGFVPSVFRNSSDSHIHHSNGHTNGSSPGVATEEIPLEDFDDEQKRASRISYENQKRVSSMN
InterPro domains: - IPR023214: HAD superfamily (homologous_superfamily) [1052-1279]
- IPR036412: HAD-like superfamily (homologous_superfamily) [754-1287]
- IPR032631: P-type ATPase, N-terminal (domain) [249-310]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [741-1292]
- IPR006539: P-type ATPase, subfamily IV (family) [260-1526]
- IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [478-627]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [765-1064]
- IPR032630: P-type ATPase, C-terminal (domain) [1269-1519]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [761-767]
- IPR001757: P-type ATPase (family) [1205-1321]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [252-1518]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0140326 (ATPase-coupled intramembrane lipid transporter activity), GO:0005319 (lipid transporter activity), GO:0140303 (intramembrane lipid transporter activity), GO:0140327 (flippase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0007163 (establishment or maintenance of cell polarity), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0097035 (regulation of membrane lipid distribution), GO:0016043 (cellular component organization), GO:0010033 (response to organic substance), GO:0006869 (lipid transport), GO:0019236 (response to pheromone), GO:0034204 (lipid translocation), GO:0071310 (cellular response to organic substance), GO:0000749 (response to pheromone triggering conjugation with cellular fusion), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0061024 (membrane organization), GO:0015914 (phospholipid transport), GO:0045332 (phospholipid translocation), GO:0006897 (endocytosis), GO:0015748 (organophosphate ester transport), GO:0071444 (cellular response to pheromone)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)