Protein: RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1) (Q6NUQ1)
Organism: Homo sapiens (Human)
Function: Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
Subcellular location: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence: MLPAGEIGASPAAPCCSESGDERKNLEEKSDINVTVLIGSKQVSEGTDNGDLPSYVSAFIEKEVGNDLKSLKKLDKLIEQRTVSKMQLEEQVLTISSEIPKRIRSALKNAEESKQFLNQFLEQETHLFSAINSHLLTAQPWMDDLGTMISQIEEIERHLAYLKWISQIEELSDNIQQYLMTNNVPEAASTLVSMAELDIKLQESSCTHLLGFMRATVKFWHKILKDKLTSDFEEILAQLHWPFIAPPQSQTVGLSRPASAPEIYSYLETLFCQLLKLQTSDELLTEPKQLPEKYSLPASPSVILPIQVMLTPLQKRFRYHFRGNRQTNVLSKPEWYLAQVLMWIGNHTEFLDEKIQPILDKVGSLVNARLEFSRGLMMLVLEKLATDIPCLLYDDNLFCHLVDEVLLFERELHSVHGYPGTFASCMHILSEETCFQRWLTVERKFALQKMDSMLSSEAAWVSQYKDITDVDEMKVPDCAETFMTLLLVITDRYKNLPTASRKLQFLELQKDLVDDFRIRLTQVMKEETRASLGFRYCAILNAVNYISTVLADWADNVFFLQLQQAALEVFAENNTLSKLQLGQLASMESSVFDDMINLLERLKHDMLTRQVDHVFREVKDAAKLYKKERWLSLPSQSEQAVMSLSSSACPLLLTLRDHLLQLEQQLCFSLFKIFWQMLVEKLDVYIYQEIILANHFNEGGAAQLQFDMTRNLFPLFSHYCKRPENYFKHIKEACIVLNLNVGSALLLKDVLQSASGQLPATAALNEVGIYKLAQQDVEILLNLRTNWPNTGK
InterPro domains: - IPR042044: EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2 (homologous_superfamily) [591-715]
- IPR007528: RINT-1/Tip20 (family) [47-792]
Interaction partners: - Vesicle transport protein SEC20
- Centromere/kinetochore protein zw10 homolog
- NBAS subunit of NRZ tethering complex
- Syntaxin-18
- Vesicle transport protein USE1
- Vesicle-trafficking protein SEC22b
- Ras-related protein Rab-18
- Sec1 family domain-containing protein 1
- Sec1 family domain-containing protein 2
- UPF0449 protein C19orf25
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0065008 (regulation of biological quality), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0044249 (cellular biosynthetic process), GO:0031647 (regulation of protein stability), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0045184 (establishment of protein localization), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0071705 (nitrogen compound transport), GO:0009100 (glycoprotein metabolic process), GO:0010256 (endomembrane system organization), GO:0015031 (protein transport), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0050821 (protein stabilization), GO:0034645 (cellular macromolecule biosynthetic process), GO:0008104 (protein localization), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0006996 (organelle organization), GO:0048193 (Golgi vesicle transport), GO:0033365 (protein localization to organelle), GO:0007030 (Golgi organization), GO:0009101 (glycoprotein biosynthetic process), GO:0006890 (retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum), GO:0006891 (intra-Golgi vesicle-mediated transport), GO:0034067 (protein localization to Golgi apparatus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0099023 (vesicle tethering complex), GO:0005829 (cytosol), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0017119 (Golgi transport complex), GO:0098791 (Golgi apparatus subcompartment), GO:0043228 (non-membrane-bounded organelle), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0032588 (trans-Golgi network membrane), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005802 (trans-Golgi network), GO:0070013 (intracellular organelle lumen), GO:0000139 (Golgi membrane), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)