Protein: Homeobox protein SHOOT MERISTEMLESS (Q38874)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for shoot apical meristem (SAM) formation during embryogenesis. Negatively regulates ASYMMETRIC LEAVES1 (AS1) and ASYMMETRIC LEAVES2 (AS2 or LBD6). Probably binds to the DNA sequence 5'-TGAC-3'. Binds to RNA (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00559, ECO:0000269|PubMed:16513846, ECO:0000269|PubMed:29742441}. Cell junction, plasmodesma {ECO:0000269|PubMed:29742441}. Cytoplasm {ECO:0000269|PubMed:17965274}. Endosome {ECO:0000269|PubMed:29742441}. Cell membrane {ECO:0000269|PubMed:29742441}. Note=Association with TALE/BELL proteins is necessary for nuclear location (PubMed:16513846). Dynamic localization via a plasmodesmata-mediated cell-to-cell transport. This shuttle is repressed by MBP2C binding in cytosolic punctae, at microtubules (PubMed:17965274). Subcellular localization and trafficking is regulated by FTIP3 and FTIP4, which promote endosome localization (PubMed:29742441). {ECO:0000269|PubMed:16513846, ECO:0000269|PubMed:17965274, ECO:0000269|PubMed:29742441}.
Sequence: MESGSNSTSCPMAFAGDNSDGPMCPMMMMMPPIMTSHQHHGHDHQHQQQEHDGYAYQSHHQQSSSLFLQSLAPPQGTKNKVASSSSPSSCAPAYSLMEIHHNEIVAGGINPCSSSSSSASVKAKIMAHPHYHRLLAAYVNCQKVGAPPEVVARLEEACSSAAAAAASMGPTGCLGEDPGLDQFMEAYCEMLVKYEQELSKPFKEAMVFLQRVECQFKSLSLSSPSSFSGYGETAIDRNNNGSSEEEVDMNNEFVDPQAEDRELKGQLLRKYSGYLGSLKQEFMKKRKKGKLPKEARQQLLDWWSRHYKWPYPSEQQKLALAESTGLDQKQINNWFINQRKRHWKPSEDMQFVVMDATHPHHYFMDNVLGNPFPMDHISSTML
InterPro domains: - IPR005540: KNOX1 (domain) [119-163]
- IPR001356: Homeodomain (domain) [282-349]
- IPR008422: KN homeodomain (domain) [302-341]
- IPR005539: ELK domain (domain) [262-283]
- IPR005541: KNOX2 (domain) [170-221]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [284-360]
- IPR017970: Homeobox, conserved site (conserved_site) [320-343]
- IPR050224: Three Amino acid Loop Extension (TALE) homeobox (family) [46-351]
Interaction partners: - BEL1-like homeodomain protein 9
- Homeobox protein ATH1
- Homeobox-leucine zipper protein ATHB-23
- Homeobox protein BEL1 homolog
- AT-hook motif nuclear-localized protein 11
- Protein phosphatase 2C 32
- At3g13845
- AT1G25275 protein
- Transmembrane protein
- Secreted transmembrane peptide 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0051606 (detection of stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0009593 (detection of chemical stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009314 (response to radiation), GO:0070887 (cellular response to chemical stimulus), GO:0009735 (response to cytokinin), GO:0009416 (response to light stimulus), GO:0034097 (response to cytokine), GO:0071310 (cellular response to organic substance), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)