Protein: Ubiquitin carboxyl-terminal hydrolase UCH54 (EC 3.4.19.12) (PfUCH37) (PfUCH54) (Q8IIJ6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8.
Sequence: MARDNENILEEWCLIESNPCIFYDMLKRMGATEISVEDVYSLSYFDDYINNKEIINMNHILGVDTYLGENNKTLDKENNVVDVIELYKNNICMEDKYNKLLKHHSYIYGIIFLFNIGKHYKNNKYIEHNVPDNLFFAKQVIPNACATQAILSIVLNKDIELNDEIKNIKTFSLNFDSSMKGLTLSNCTFLRNIHNSYKPPIYLDKEDVHHDKKKSEDSFHFVSYISFQDKVYLLDGLQSGPVLINADEQNKPNPNNNNNNKDNDNDNNNNNNNNNNNNNNNNNNNNNNNNNNIGMNGKDWIEISREHIKKEIDEICNSQTNNDVRFNIIAVMKDKEYIIQEYINIHRIVKQRVNIKLINLGENIELSDEINEDEFPLLNDIPSIENLPNNVDTLYNIVNKSTLEINYLQSLLHEQKEIKKLWNKELTFKFFNFYPFIMSSLNLMAKHKLLKDAYQKEKLKNATKS
InterPro domains: - IPR036959: Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily (homologous_superfamily) [4-336]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [11-334]
- IPR001578: Peptidase C12, ubiquitin carboxyl-terminal hydrolase (domain) [11-409]
Interaction partners: - 26S proteasome regulatory subunit RPN10, putative
- 26S proteasome regulatory subunit RPN13, putative
- 26S proteasome regulatory subunit RPN12, putative
- 26S proteasome regulatory subunit RPN1, putative
- Proteasome subunit alpha type-1, putative
- 26S proteasome regulatory subunit RPN6
- 26S proteasome regulatory subunit RPN8, putative
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit RPN9, putative
- 26S proteasome regulatory subunit p55, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070646 (protein modification by small protein removal), GO:0070647 (protein modification by small protein conjugation or removal), GO:0016579 (protein deubiquitination), GO:0000338 (protein deneddylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0022624 (proteasome accessory complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005838 (proteasome regulatory particle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1905368 (peptidase complex), GO:0000502 (proteasome complex), GO:1905369 (endopeptidase complex)