Protein: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b (E7FGT3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Golgi apparatus. Membrane
Sequence: MPDQISVSEFLSETTEDYNSPTTSSFTTRLQSCRNTVSVLEEALDQDRTSLQKVKKSVKAIYNSGQDHIQNEETYSQALDKFGSNFISRDNPDLGTAFVKFSTLTKELSALLKNLLQNLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQVDQKEDSQSKQGGYSMHQLQGNKEFGCEKKGYLLKKSDGLRKVWQRRKCSVKGGILTISHATSNRQPVKLNLLTCQVKPSAEDRKCFDLISHNRTYHFQAEDEQEFIIWISVLTNSKEEALNMAFRGEQGGGDDGLEDLTKAIIDDVLRMPGNEWCCDCGAPDPKWLSTNLGILTCIECSGIHREMGVHISRIQSMELDKLGTSELLLAKNVGNSSFNDIMEGGLSCPSSKPTPSSDMTVRKEFINAKYVDHKFARKTCSSAEDKRSDLFKAVGSHDLLALIQVYAEGVELLEPLHEGGQEGGETALHYAVRTADQTSLHLVDFLVQNSGNLDKQTERGNTALHYCCLYEKHECLKLLLRGKPATDITNQNGDTALDVARRMKLFQCEEALVQAAAGKFNTKVHVEYEWNLRLEELDESDDDLDYKPSPIKKDRSPRPQSFCHSSSLSPHDKLSLPAFIGQRDKQRLSYSAFTNQMYSVSTDCPSSPVSDAPPLPPRNAGKAPPLSNLPPSTLAPASQTSPSGSSTLSKKRPPPPPPGHKRTLSDPPTPLFKGSDSTPPPVNKMSPVTNRFEGIPQQQSPNTTKPTLGPRVLPKLPQKVALRKIDTIHHPSVDKTNQPSEAVLFQKVLQSSDTSQKVPIADRPQPGDVAPQRPQPSELPPKPGELPPKPQLSELPPKPQLGDLPPKPQLKDLPPKPQLADISPAKPITIEVPPKPSPGEVAPKPQPPDTPTIIQQGELSPQPVIQSSEDTNGSPTSAQDTPVPLPRKINPIKSKMRRVKTIYDCQADNDDELTFAEGEVIVVTGEEDQEWWIGHIEGQPERKGVFPMSFVHILSD
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [1023-1112]
- IPR038016: ASAP1, SH3 domain (domain) [1055-1111]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [299-413]
- IPR037928: ASAP1, BAR domain (domain) [34-248]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [418-535]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [414-540]
- IPR001849: Pleckstrin homology domain (domain) [304-398]
- IPR001452: SH3 domain (domain) [1051-1113]
- IPR002110: Ankyrin repeat (repeat) [580-679]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [540-689]
- IPR043593: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein (family) [1-1113]
- IPR037844: ASAP, PH domain (domain) [296-402]
- IPR001164: Arf GTPase activating protein (domain) [419-542]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [19-327]
- IPR004148: BAR domain (domain) [34-266]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0003824 (catalytic activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0005096 (GTPase activator activity), GO:0030695 (GTPase regulator activity), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016477 (cell migration), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:0001764 (neuron migration), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0048699 (generation of neurons), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)