Protein: BTB/POZ domain-containing protein KCTD5 (Q9NXV2)
Organism: Homo sapiens (Human)
Function: Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:17239418}. Cytoplasm {ECO:0000269|PubMed:18573101}. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins. {ECO:0000269|PubMed:18573101}.
Sequence: MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTASEPSEKAKILQERGSRM
InterPro domains: - IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [46-134]
- IPR000210: BTB/POZ domain (domain) [44-146]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [33-148]
Interaction partners: - Cullin-3
- BTB/POZ domain-containing protein KCTD17
- A-type voltage-gated potassium channel KCND2
- BTB/POZ domain-containing protein KCTD2
- BTB/POZ domain-containing protein KCTD11
- BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1
- E3 ubiquitin-protein ligase RBX1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:1901564 (organonitrogen compound metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0098771 (inorganic ion homeostasis), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0043170 (macromolecule metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0009057 (macromolecule catabolic process), GO:0055080 (monoatomic cation homeostasis), GO:1901565 (organonitrogen compound catabolic process), GO:0031344 (regulation of cell projection organization), GO:0006508 (proteolysis), GO:0031346 (positive regulation of cell projection organization), GO:0044265 (cellular macromolecule catabolic process), GO:1902117 (positive regulation of organelle assembly), GO:0030163 (protein catabolic process), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0033043 (regulation of organelle organization), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0010638 (positive regulation of organelle organization), GO:1902115 (regulation of organelle assembly), GO:0060491 (regulation of cell projection assembly), GO:0055074 (calcium ion homeostasis), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0045724 (positive regulation of cilium assembly), GO:1902017 (regulation of cilium assembly), GO:0006874 (intracellular calcium ion homeostasis), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0032469 (endoplasmic reticulum calcium ion homeostasis), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0031463 (Cul3-RING ubiquitin ligase complex)