Protein: EPH receptor B2 (EPHB2 protein) (Q6NVW1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKMKTQRS
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [324-476]
- IPR011641: Tyrosine-protein kinase ephrin type A/B receptor-like (domain) [268-302]
- IPR003961: Fibronectin type III (domain) [324-482]
- IPR001426: Tyrosine-protein kinase, receptor class V, conserved site (conserved_site) [178-261]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [325-482]
- IPR034238: Ephrin type-B receptor 2, ligand binding domain (domain) [19-196]
- IPR001090: Ephrin receptor ligand binding domain (domain) [20-202]
- IPR050449: Ephrin receptor tyrosine kinases (family) [20-481]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [253-381]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [20-195]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0007155 (cell adhesion), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0040012 (regulation of locomotion), GO:1901564 (organonitrogen compound metabolic process), GO:2000145 (regulation of cell motility), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0007166 (cell surface receptor signaling pathway), GO:0006935 (chemotaxis), GO:0043170 (macromolecule metabolic process), GO:0031589 (cell-substrate adhesion), GO:0044087 (regulation of cellular component biogenesis), GO:0036211 (protein modification process), GO:0060326 (cell chemotaxis), GO:0043412 (macromolecule modification), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007399 (nervous system development), GO:0051216 (cartilage development), GO:0001501 (skeletal system development), GO:0061448 (connective tissue development), GO:0072359 (circulatory system development), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0030335 (positive regulation of cell migration), GO:0030334 (regulation of cell migration), GO:1902531 (regulation of intracellular signal transduction), GO:0007507 (heart development), GO:0043408 (regulation of MAPK cascade), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0006468 (protein phosphorylation), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0046328 (regulation of JNK cascade), GO:0048013 (ephrin receptor signaling pathway), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)