Protein: 26S proteasome regulatory subunit 8 homolog B (26S proteasome AAA-ATPase subunit RPT6b) (26S proteasome subunit 8 homolog B) (Regulatory particle triple-A ATPase subunit 6b) (Q94BQ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Sequence: MAAVGVEARPPVTAMEETCNVKGAAAKQGEGLNKYYLQHLDELQRLQREKSYNLNRLEAQRNELNSRVRMLREELQLLQEPGSYVGEVVKVMGKNKVLVKVHPEGKYVVDIDKSIDITKLTPSTRVALRNDSYVLHLVLPSKVDPLVNLMKVEKVPDSTYDMIGGLDQQIKEIKEVIELPIKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSARMESGSGNGDSEVQRTMLELLNQLDGFEASNKIKVLMATNRIDILDQALLRPGRIDRKIEFPNPNEESRFDILKIHSRKMNLMRGIDLKKIAEKMNGASGAELKAVCTEAGMFALRERRVHVTQEDFEMAVAKVMKKDTEKNMSLRKLWK
InterPro domains: - IPR003960: ATPase, AAA-type, conserved site (conserved_site) [302-320]
- IPR003593: AAA+ ATPase domain (domain) [194-334]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [355-397]
- IPR003959: ATPase, AAA-type, core (domain) [198-331]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [151-410]
- IPR050221: 26S Proteasome Regulatory ATPase (family) [47-409]
- IPR032501: Proteasomal ATPase, second OB domain (domain) [85-140]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [37-150]
Interaction partners: - 26S proteasome non-ATPase regulatory subunit 11 homolog
- 26S proteasome regulatory subunit 6B homolog
- 26S proteasome non-ATPase regulatory subunit 6 homolog
- 26S proteasome regulatory subunit 4 homolog A
- 26S proteasome non-ATPase regulatory subunit 4 homolog
- 26S proteasome regulatory subunit 6A homolog A
- 26S proteasome regulatory subunit 4 homolog B
- 26S proteasome regulatory subunit 6A homolog B
- 26S proteasome regulatory subunit 7 homolog A
- 26S proteasome non-ATPase regulatory subunit 7 homolog A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0012501 (programmed cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0061077 (chaperone-mediated protein folding), GO:0009756 (carbohydrate mediated signaling), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0099402 (plant organ development), GO:0055082 (intracellular chemical homeostasis), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0090066 (regulation of anatomical structure size), GO:0032535 (regulation of cellular component size), GO:0009416 (response to light stimulus), GO:0048364 (root development), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0030163 (protein catabolic process), GO:0010468 (regulation of gene expression), GO:0022622 (root system development), GO:0009057 (macromolecule catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0006355 (regulation of DNA-templated transcription), GO:0008361 (regulation of cell size), GO:0051603 (proteolysis involved in protein catabolic process), GO:0009639 (response to red or far red light), GO:0010498 (proteasomal protein catabolic process), GO:0048366 (leaf development), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:1902494 (catalytic complex), GO:0055044 (symplast), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0043231 (intracellular membrane-bounded organelle), GO:0009505 (plant-type cell wall), GO:0005911 (cell-cell junction), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)