Protein: Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (mGPAT3) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta) (Q8C0N2)
Organism: Mus musculus (Mouse)
Function: Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Protects cells against lipotoxicity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17170135}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MEGADLAVKLLSTWLTLVGGLILLPSAFGLSLGISEIYMKILVKTLEWATLRIQKGAPKESALKNSASVGIIQRDESPMEKGLSGLRGRDFELSDVFYFSKKGLEAIVEDEVTQRFSSEELVSWNLLTRTNVNFQYISPRLTMVWVLGVLVRYCFLLPLRVTLAFIGISLLIIGTTLVGQLPDSSLKNWLSELVHLTCCRICVRSLSGTIHYHNKQYRPQKGGICVANHTSPIDVLILATDGCYAMVGQVHGGLMGIIQRAMVKACPHVWFERSEIKDRHLVTKRLKEHIADKKKLPILIFPEGTCINNTSVMMFKKGSFEIGGTIYPVAIKYNPQFGDAFWNSSKYNLVSYLLRIMTSWAIVCDVWYMPPMTREEGEDAVQFANRVKSAIAVQGGLTELPWDGGLKRAKVKDTFKEEQQKNYSKMIVGNGSPNLARD
InterPro domains: - IPR045252: Lysophosphatidylcholine acyltransferase LPCAT1-like (domain) [199-408]
- IPR002123: Phospholipid/glycerol acyltransferase (domain) [210-334]
Interaction partners: - Glycerol-3-phosphate acyltransferase 1, mitochondrial
- Glycerol-3-phosphate acyltransferase 2, mitochondrial
- Glycerol kinase
- Glycerol kinase 2
- Glycerol-3-phosphate dehydrogenase 1-like protein
- glycerol kinase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- Acylglycerol kinase, mitochondrial
- Glycerol-3-phosphate dehydrogenase [NAD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051234 (establishment of localization), GO:0021700 (developmental maturation), GO:0051239 (regulation of multicellular organismal process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0040008 (regulation of growth), GO:0050878 (regulation of body fluid levels), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0009888 (tissue development), GO:0040014 (regulation of multicellular organism growth), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0006082 (organic acid metabolic process), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0048638 (regulation of developmental growth), GO:0071695 (anatomical structure maturation), GO:0006631 (fatty acid metabolic process), GO:0046460 (neutral lipid biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0007589 (body fluid secretion), GO:0002064 (epithelial cell development), GO:0043436 (oxoacid metabolic process), GO:0048732 (gland development), GO:0046903 (secretion), GO:0006638 (neutral lipid metabolic process), GO:0060429 (epithelium development), GO:0002070 (epithelial cell maturation), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0030855 (epithelial cell differentiation), GO:0046463 (acylglycerol biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0030879 (mammary gland development), GO:0007595 (lactation), GO:0002066 (columnar/cuboidal epithelial cell development), GO:0006639 (acylglycerol metabolic process), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0002068 (glandular epithelial cell development), GO:0046339 (diacylglycerol metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006641 (triglyceride metabolic process), GO:0019432 (triglyceride biosynthetic process), GO:0002067 (glandular epithelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)