Protein: Protein CLASP-3 (Q03609)
Organism: Caenorhabditis elegans
Function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Sequence: MTSRMQPKSGVYSVSKADFTKIFEDVPKVPITSAVDLRNKFDAVRIILSNSSEDWNKRQTQLKTVRSLVIHGEKVVDRPTMIAHLVQLLGCFELAVKDLRSQVLREAAITCSFIVSKYGIETHSIGEDILVPAMSQVAVSTKIMATSASTLTEFIVEYVQTRQVFTILSSFSTSKDKSQRRQLAALLEIVISKWSDRIKKQIMRQICELIKSAINDADSETRAAGRRAFAKLDEMHSEEADALYLELDHSKQKMLRGGDAASSWASVNSEKGSIPIRSKLSAGSKAHMNISAKFLAQRSASAIDPKATKFAGPSRLVRPTSTKTMARQDTSPAGCKYSNFISMFFKTLLLSAKIPYPNRPGSRTRTSSITSTDSRDTSPTRRNSPLPPETQKARVKYGNGSFFAKLGMPDTTDDDEFLLPIRIRSPLKTPTIEAHDKVSQVLKECCSSSVSEKKEGIKKLLPIVADTSLNPIEIKNIGNCLNRLLSDASNTMVLEIYSIFVRTHSSRLSEWLRLALAKLFARKAAETLPNTKKQIGHTLNVILECFNAHHQLVTVCELMCDPIHLMVPKARVVLLEYLTSLLDEYTEPGASINAKELKTAIRKMLTWASDPRLSILLTPHVEKAICSMFCVNVADFSALISDLDSEQKNWIHQTLQRNGLENGISSNNIATNSGATASRETSNTSFQKESTSFGLPEFGARKGGTGVNLGSLNISNNLALSRLEEQSTSRLMEKVNLNSTVTLPPDTLEKIQNVQDLLQKMRSSENADEQESAISSIYMMICDGGFGVWEQCYAKLLLNLFEILSKSRSENNKKMCLRILGKMCTAQAAKLFDSTEMAVCKVLDAAVNTNDATTALAVEDCLRTLATHLPLSNIINIAKVILNQEPIDDERASLVLKMVTRLFEELPAEELNNIVDDITPTIIKAYQSTSSTVRKTVVYCLVAMVNRVGEQRMTPHFTKLPKAMTNLIQVYVNRAISTSLPRL
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [51-961]
- IPR011989: Armadillo-like helical (homologous_superfamily) [13-976]
- IPR024395: CLASP N-terminal domain (domain) [39-255]
- IPR034085: TOG domain (domain) [36-981]
Interaction partners: - Putative extracellular sulfatase Sulf-1 homolog
- HoloCentric chromosome binding Protein
- Calponin homology domain-containing protein
- HoloCentric chromosome binding Protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0051640 (organelle localization), GO:1903046 (meiotic cell cycle process), GO:0007017 (microtubule-based process), GO:0000910 (cytokinesis), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0007051 (spindle organization), GO:0051649 (establishment of localization in cell), GO:0045132 (meiotic chromosome segregation), GO:0000226 (microtubule cytoskeleton organization), GO:0008608 (attachment of spindle microtubules to kinetochore), GO:0051255 (spindle midzone assembly), GO:0051307 (meiotic chromosome separation), GO:0051304 (chromosome separation), GO:0007059 (chromosome segregation), GO:0140013 (meiotic nuclear division), GO:0046907 (intracellular transport), GO:0051653 (spindle localization), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0051316 (attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation), GO:0051231 (spindle elongation), GO:0016043 (cellular component organization), GO:0000212 (meiotic spindle organization), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0098813 (nuclear chromosome segregation), GO:0140014 (mitotic nuclear division), GO:0030953 (astral microtubule organization), GO:0031122 (cytoplasmic microtubule organization), GO:0051256 (mitotic spindle midzone assembly), GO:0000022 (mitotic spindle elongation), GO:0007052 (mitotic spindle organization), GO:0022607 (cellular component assembly), GO:0031109 (microtubule polymerization or depolymerization), GO:0051225 (spindle assembly), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0051293 (establishment of spindle localization), GO:0031134 (sister chromatid biorientation), GO:0016482 (cytosolic transport), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0097435 (supramolecular fiber organization), GO:0000281 (mitotic cytokinesis), GO:0070925 (organelle assembly), GO:0040001 (establishment of mitotic spindle localization), GO:0065003 (protein-containing complex assembly), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0007010 (cytoskeleton organization), GO:0000819 (sister chromatid segregation), GO:0090307 (mitotic spindle assembly), GO:0046785 (microtubule polymerization), GO:0000280 (nuclear division), GO:0051258 (protein polymerization), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0051233 (spindle midzone), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000776 (kinetochore), GO:0005813 (centrosome), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000793 (condensed chromosome), GO:0015630 (microtubule cytoskeleton), GO:0072686 (mitotic spindle)