Protein: Glucose-6-phosphatase 2 (Q9Z186)
Organism: Mus musculus (Mouse)
Function: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MDFLHRSGVLIIHHLQEDYRTYYGFLNFMSNVGDPRNIFSIYFPLWFQLNQNVGTKMIWVAVIGDWFNLIFKWILFGHRPYWWIQETEIYPNHSSPCLEQFPTTCETGPGSPSGHAMGSSCVWYVMVTAALSYTISRMEESSVTLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGVHMASLSVYLKTNVFLFLFALGFYLLLRLFGIDLLWSVPIAKKWCANPDWIHIDSTPFAGLVRNLGVLFGLGFAINSEMFLRSCQGENGTKPSFRLLCALTSLTTMQLYRFIKIPTHAEPLFYLLSFCKSASIPLMVVALIPYCVHMLMRPGDKKTK
InterPro domains: - IPR016275: Glucose-6-phosphatase (family) [1-354]
- IPR000326: Phosphatidic acid phosphatase type 2/haloperoxidase (domain) [53-194]
- IPR036938: Phosphatidic acid phosphatase type 2/haloperoxidase superfamily (homologous_superfamily) [16-193]
Interaction partners: - Hexokinase-4
- Hexokinase-1
- Hexokinase HKDC1
- Hexokinase-3
- Hexokinase-2
- Phosphoglucomutase-1
- Glucose-6-phosphatase catalytic subunit 1
- GDH/6PGL endoplasmic bifunctional protein
- Glucose-6-phosphate isomerase
- Glucose-6-phosphatase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0050308 (sugar-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0035264 (multicellular organism growth), GO:0044238 (primary metabolic process), GO:0055088 (lipid homeostasis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0033500 (carbohydrate homeostasis), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006810 (transport), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0046415 (urate metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0019318 (hexose metabolic process), GO:0008202 (steroid metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0071702 (organic substance transport), GO:0006638 (neutral lipid metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0051156 (glucose 6-phosphate metabolic process), GO:0010468 (regulation of gene expression), GO:0044264 (cellular polysaccharide metabolic process), GO:0009057 (macromolecule catabolic process), GO:0046486 (glycerolipid metabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0055092 (sterol homeostasis), GO:0042593 (glucose homeostasis), GO:0005976 (polysaccharide metabolic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0016052 (carbohydrate catabolic process), GO:0006006 (glucose metabolic process), GO:0015748 (organophosphate ester transport), GO:0044042 (glucan metabolic process), GO:0019319 (hexose biosynthetic process), GO:1901264 (carbohydrate derivative transport), GO:0006112 (energy reserve metabolic process), GO:0006639 (acylglycerol metabolic process), GO:0006073 (cellular glucan metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0044247 (cellular polysaccharide catabolic process), GO:0042632 (cholesterol homeostasis), GO:0005977 (glycogen metabolic process), GO:0006094 (gluconeogenesis), GO:0006641 (triglyceride metabolic process), GO:0005980 (glycogen catabolic process), GO:0009251 (glucan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)