Protein: Glucose-dependent insulinotropic receptor (G-protein coupled receptor 119) (Q7TQP3)
Organism: Mus musculus (Mouse)
Function: Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
InterPro domains: - IPR028336: Glucose-dependent insulinotropic receptor (family) [6-290]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [21-279]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [6-287]
Interaction partners: - Guanine nucleotide-binding protein G
- Pro-glucagon
- Gastric inhibitory polypeptide
- Pro-opiomelanocortin
- VIP peptides
- G-protein coupled receptor 55
- Pituitary adenylate cyclase-activating polypeptide
- Natriuretic peptides A
- N-arachidonyl glycine receptor
- Free fatty acid receptor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0043410 (positive regulation of MAPK cascade), GO:0051057 (positive regulation of small GTPase mediated signal transduction), GO:0046578 (regulation of Ras protein signal transduction), GO:0046579 (positive regulation of Ras protein signal transduction), GO:0035023 (regulation of Rho protein signal transduction), GO:0035025 (positive regulation of Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex)