Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (B3KNX7)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHSSRL
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [261-519]
- IPR000719: Protein kinase domain (domain) [270-521]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [385-397]
- IPR000095: CRIB domain (domain) [74-132]
- IPR033923: p21 activated kinase binding domain (domain) [73-118]
- IPR017441: Protein kinase, ATP binding site (binding_site) [276-299]
- IPR051931: Serine/threonine-protein kinase PAK 3-like (family) [85-519]
- IPR036936: CRIB domain superfamily (homologous_superfamily) [70-149]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060090 (molecular adaptor activity), GO:0016740 (transferase activity), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0005518 (collagen binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0051020 (GTPase binding), GO:0015631 (tubulin binding), GO:0031267 (small GTPase binding), GO:0043015 (gamma-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009607 (response to biotic stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002253 (activation of immune response), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009653 (anatomical structure morphogenesis), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0051606 (detection of stimulus), GO:0001763 (morphogenesis of a branching structure), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:2000145 (regulation of cell motility), GO:0048729 (tissue morphogenesis), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0009595 (detection of biotic stimulus), GO:0032886 (regulation of microtubule-based process), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0002218 (activation of innate immune response), GO:0006793 (phosphorus metabolic process), GO:0035295 (tube development), GO:0002433 (immune response-regulating cell surface receptor signaling pathway involved in phagocytosis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:0002764 (immune response-regulating signaling pathway), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0009611 (response to wounding), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0061138 (morphogenesis of a branching epithelium), GO:0051130 (positive regulation of cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0002757 (immune response-activating signaling pathway), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0002833 (positive regulation of response to biotic stimulus), GO:1990840 (response to lectin), GO:0006810 (transport), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0033143 (regulation of intracellular steroid hormone receptor signaling pathway), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0043254 (regulation of protein-containing complex assembly), GO:0060245 (detection of cell density), GO:0002758 (innate immune response-activating signaling pathway), GO:0051246 (regulation of protein metabolic process), GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis), GO:0032956 (regulation of actin cytoskeleton organization), GO:0002009 (morphogenesis of an epithelium), GO:0030334 (regulation of cell migration), GO:0048754 (branching morphogenesis of an epithelial tube), GO:1902903 (regulation of supramolecular fiber organization), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0032233 (positive regulation of actin filament bundle assembly), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0043412 (macromolecule modification), GO:0032231 (regulation of actin filament bundle assembly), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:0060562 (epithelial tube morphogenesis), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0045088 (regulation of innate immune response), GO:0006974 (cellular response to DNA damage stimulus), GO:0031532 (actin cytoskeleton reorganization), GO:0006325 (chromatin organization), GO:0006796 (phosphate-containing compound metabolic process), GO:1990858 (cellular response to lectin), GO:0036211 (protein modification process), GO:0042060 (wound healing), GO:0033145 (positive regulation of intracellular steroid hormone receptor signaling pathway), GO:0051247 (positive regulation of protein metabolic process), GO:0033043 (regulation of organelle organization), GO:0016192 (vesicle-mediated transport), GO:0051338 (regulation of transferase activity), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0031116 (positive regulation of microtubule polymerization), GO:0006909 (phagocytosis), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0032271 (regulation of protein polymerization), GO:0031113 (regulation of microtubule polymerization), GO:0045937 (positive regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:0007010 (cytoskeleton organization), GO:0006338 (chromatin remodeling), GO:0110020 (regulation of actomyosin structure organization), GO:0043549 (regulation of kinase activity), GO:0051496 (positive regulation of stress fiber assembly), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0031112 (positive regulation of microtubule polymerization or depolymerization), GO:0031401 (positive regulation of protein modification process), GO:0043408 (regulation of MAPK cascade), GO:0033146 (regulation of intracellular estrogen receptor signaling pathway), GO:0038093 (Fc receptor signaling pathway), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0002431 (Fc receptor mediated stimulatory signaling pathway), GO:0002223 (stimulatory C-type lectin receptor signaling pathway), GO:0006468 (protein phosphorylation), GO:0019220 (regulation of phosphate metabolic process), GO:0110053 (regulation of actin filament organization), GO:0051492 (regulation of stress fiber assembly), GO:0051495 (positive regulation of cytoskeleton organization), GO:0032273 (positive regulation of protein polymerization), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0043406 (positive regulation of MAP kinase activity), GO:0001934 (positive regulation of protein phosphorylation), GO:0048013 (ephrin receptor signaling pathway), GO:0042325 (regulation of phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0038094 (Fc-gamma receptor signaling pathway), GO:0046777 (protein autophosphorylation), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0043507 (positive regulation of JUN kinase activity), GO:0033138 (positive regulation of peptidyl-serine phosphorylation), GO:0033135 (regulation of peptidyl-serine phosphorylation), GO:0045860 (positive regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:0043506 (regulation of JUN kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0099080 (supramolecular complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0001726 (ruffle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099081 (supramolecular polymer), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0070013 (intracellular organelle lumen), GO:0005911 (cell-cell junction), GO:0099513 (polymeric cytoskeletal fiber), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0015629 (actin cytoskeleton), GO:0005884 (actin filament)