Protein: Histone-lysine N-methyltransferase EZH2 (Q08BS4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes
Subcellular location: Nucleus
Sequence: MGLTGRKSEKGPVCWRRRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTDILNQEWKLRRIQPVHIMTPVSSLRGTRECTVDSGFSEFSRQVIPLKTLNAVASVPVMYSWSPLQQNFMVEDETVLHNIPYMGDEILDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALNQYSDNEEDDEEDDHHDYKFEKMDLCDGKDDAEDHKEQLSSESHNNDGSKKFPSDKIFEAISSMFPDKGSTEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFQATPNTYKRKNMENLVDSKPCGIYCYMYMVQDGMVREYPAGVVPERAKTPSKRSTGRRRGRLPNSNSRPSTPTVNSETKDTDSDREGGADGNDSNDKDDDDKKDETTSSSEANSRCQTPVKLKLSSEPPENVDWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIARAPAVDENTPQRKKKRKHRLWATHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAAEHWDSKNVSCKNCSIQRGAKKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
InterPro domains: - IPR021654: Histone-lysine N-methyltransferase EZH1/EZH2 (family) [39-68]
- IPR026489: CXC domain (domain) [517-619]
- IPR044439: EZH2, SET domain (domain) [623-742]
- IPR046341: SET domain superfamily (homologous_superfamily) [519-750]
- IPR045318: Histone-lysine N-methyltransferase EZH1/2-like (family) [10-755]
- IPR041355: Pre-SET CXC domain (domain) [573-604]
- IPR001214: SET domain (domain) [626-747]
- IPR041343: Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain (domain) [159-262]
- IPR033467: Tesmin/TSO1-like CXC domain (domain) [569-607]
- IPR001005: SANT/Myb domain (domain) [160-490]
- IPR048358: EZH1/2, MCSS domain (domain) [270-322]
Interaction partners: - Polycomb protein suz12-B
- Polycomb protein suz12-A
- Polycomb protein eed
- Histone-binding protein RBBP4
- Zinc finger protein AEBP2
- E3 ubiquitin-protein ligase RING2
- Histone-binding protein RBBP7
- DNA (cytosine-5)-methyltransferase
- Polycomb complex protein BMI-1-A
- Histone H3.3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0044238 (primary metabolic process), GO:0035295 (tube development), GO:1901564 (organonitrogen compound metabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0043414 (macromolecule methylation), GO:0001894 (tissue homeostasis), GO:0042246 (tissue regeneration), GO:0044260 (cellular macromolecule metabolic process), GO:0031099 (regeneration), GO:0043170 (macromolecule metabolic process), GO:0060249 (anatomical structure homeostasis), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0055123 (digestive system development), GO:0072359 (circulatory system development), GO:0048565 (digestive tract development), GO:0007507 (heart development), GO:0031101 (fin regeneration), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:0018205 (peptidyl-lysine modification), GO:0070734 (histone H3-K27 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)