Protein: Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) (Q62784)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
Subcellular location: Early endosome membrane {ECO:0000250|UniProtKB:Q96PE3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q96PE3}. Cell membrane {ECO:0000250|UniProtKB:Q96PE3}. Nucleus {ECO:0000250|UniProtKB:Q96PE3}. Cytoplasm {ECO:0000250|UniProtKB:Q96PE3}. Postsynaptic density {ECO:0000250|UniProtKB:Q9EPW0}. Note=Translocates to the plasma membrane upon EGF stimulation (By similarity). Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (By similarity). {ECO:0000250|UniProtKB:Q96PE3}.
Sequence: MTAREHSPRHGARARAMQRASTIDVTADMVGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQQPPVTRSLDTVNGRMVLPVDESLTEALGIRSKYASLRKDSLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEECCTSSTCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWAGRSSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGGEDVFPCSSTCSSKKDCSPPPEESCPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQTAAPTIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPLFDSLPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [50-180]
- IPR039034: Inositol 3,4-bisphosphate 4-phosphatase (family) [1-938]
- IPR000008: C2 domain (domain) [26-153]
Interaction partners: - Synaptojanin-1
- Type II inositol 1,4,5-trisphosphate 5-phosphatase
- Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
- Inositol polyphosphate 5-phosphatase OCRL
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Inositol polyphosphate-5-phosphatase A
- FIG4 phosphoinositide 5-phosphatase.
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase
- Synaptojanin-2
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity), GO:0034596 (phosphatidylinositol phosphate 4-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0043647 (inositol phosphate metabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046486 (glycerolipid metabolic process), GO:0046164 (alcohol catabolic process), GO:0006644 (phospholipid metabolic process), GO:0019751 (polyol metabolic process), GO:0030258 (lipid modification), GO:0006796 (phosphate-containing compound metabolic process), GO:0046434 (organophosphate catabolic process), GO:0046838 (phosphorylated carbohydrate dephosphorylation), GO:0006650 (glycerophospholipid metabolic process), GO:0016311 (dephosphorylation), GO:0046174 (polyol catabolic process), GO:0071545 (inositol phosphate catabolic process), GO:0046839 (phospholipid dephosphorylation), GO:0046855 (inositol phosphate dephosphorylation), GO:0046488 (phosphatidylinositol metabolic process), GO:0046856 (phosphatidylinositol dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0031965 (nuclear membrane), GO:0098984 (neuron to neuron synapse), GO:0043231 (intracellular membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0005634 (nucleus)