Protein: Intraflagellar transport protein 88 homolog (A0A096MJ06)
Organism: Rattus norvegicus (Rat)
Function: Positively regulates primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment
Subcellular location: Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Sequence: MMENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVSSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANVYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQVLPQHESVLADIILPIGQSLKKRQEATSTPPEVLSVSMESRQTELNSAV
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [148-753]
- IPR019734: Tetratricopeptide repeat (repeat) [197-688]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0019894 (kinesin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0031503 (protein-containing complex localization), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0003008 (system process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0044085 (cellular component biogenesis), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0006970 (response to osmotic stress), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0072001 (renal system development), GO:0030030 (cell projection organization), GO:0006968 (cellular defense response), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:1902533 (positive regulation of intracellular signal transduction), GO:0006996 (organelle organization), GO:0001822 (kidney development), GO:1902531 (regulation of intracellular signal transduction), GO:0007600 (sensory perception), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043410 (positive regulation of MAPK cascade), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0050954 (sensory perception of mechanical stimulus), GO:0007605 (sensory perception of sound), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0060271 (cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0031090 (organelle membrane), GO:0005794 (Golgi apparatus), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0030667 (secretory granule membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0005802 (trans-Golgi network), GO:0002080 (acrosomal membrane), GO:0097708 (intracellular vesicle)