Protein: Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase VHR) (Vaccinia H1-related phosphatase) (VHR) (P51452)
Organism: Homo sapiens (Human)
Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Subcellular location: Nucleus {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:27346674}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D7X3}.
Sequence: MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [3-185]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [99-158]
- IPR020422: Dual specificity protein phosphatase domain (domain) [28-179]
- IPR020405: Atypical dual specificity phosphatase, subfamily A (family) [8-182]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [122-132]
- IPR000340: Dual specificity phosphatase, catalytic domain (domain) [37-175]
Interaction partners: - Serine/threonine-protein kinase VRK3
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 3
- Tyrosine-protein phosphatase non-receptor type 7
- Mitogen-activated protein kinase 14
- Mitogen-activated protein kinase 8
- Receptor-type tyrosine-protein phosphatase R
- Mitogen-activated protein kinase 12
- Mitogen-activated protein kinase 9
- Mitogen-activated protein kinase 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0042802 (identical protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0008138 (protein tyrosine/serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)