Protein: Agglutinin-like protein 3 (Q59L12)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Covers the surface of the germ tube
Sequence: MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
InterPro domains: - IPR008966: Adhesion domain superfamily (homologous_superfamily) [24-174]
- IPR043063: Agglutinin-like protein, N-terminal, N2 subdomain (homologous_superfamily) [178-329]
- IPR008440: Agglutinin-like protein repeat (repeat) [365-863]
- IPR033504: Agglutinin-like protein (family) [1-693]
- IPR024672: Agglutinin-like protein, N-terminal (domain) [53-298]
- IPR011252: Fibrogen-binding domain 1 (homologous_superfamily) [17-177]
Interaction partners: - Extent of cell elongation protein 1
- Hyphal wall protein 1
- Hyphally regulated cell wall protein 1
- Cell wall protein RBT1
- Enhanced filamentous growth protein 1
- Biofilm and cell wall regulator 1
- Transcriptional regulatory protein UME6
- Secreted aspartic protease 4
- Secreted aspartic protease 5
- Cell wall adhesin EAP1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0050840 (extracellular matrix binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0001968 (fibronectin binding), GO:0043236 (laminin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0035821 (modulation of process of another organism), GO:0044403 (biological process involved in symbiotic interaction), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0030448 (hyphal growth), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0098609 (cell-cell adhesion), GO:0080134 (regulation of response to stress), GO:0030155 (regulation of cell adhesion), GO:0075136 (response to host), GO:0098771 (inorganic ion homeostasis), GO:0045785 (positive regulation of cell adhesion), GO:0090609 (single-species submerged biofilm formation), GO:0051701 (biological process involved in interaction with host), GO:0055082 (intracellular chemical homeostasis), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0098630 (aggregation of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:0071214 (cellular response to abiotic stimulus), GO:0044003 (modulation by symbiont of host process), GO:0009268 (response to pH), GO:0031349 (positive regulation of defense response), GO:0031589 (cell-substrate adhesion), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0036176 (response to neutral pH), GO:0044000 (movement in host), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:0052031 (modulation by symbiont of host defense response), GO:0043708 (cell adhesion involved in biofilm formation), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0044416 (induction by symbiont of host defense response), GO:0071467 (cellular response to pH), GO:0044406 (adhesion of symbiont to host), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0055080 (monoatomic cation homeostasis), GO:0055070 (copper ion homeostasis), GO:0042710 (biofilm formation), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006878 (intracellular copper ion homeostasis), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0090605 (submerged biofilm formation), GO:0036244 (cellular response to neutral pH), GO:0044409 (entry into host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall), GO:0030445 (yeast-form cell wall)