wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: G0/G1 switch 2 (B3DJV5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MRCGRSQKIASFKKAESECSTPTETLRITTDKQGIIIRAGSLTFDKQNSRMDTMHELIPFAKEMLSAGPSKGSLKIYLVGGTFAVLGMVSGVVQVASSLFPDHEEPDFDMLKVREVLPVKQQVQEPQTSIPEDEEMDAVMEAKAKELPSNRQRRMSFRAHAS
InterPro domains: - IPR016821: G0/G1 switch protein 2 (family) [51-162]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0006091 (generation of precursor metabolites and energy), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0045333 (cellular respiration), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: non-specific serine/threonine protein kinase (A0A286Y937)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, cilium. Cytoplasm, cytoskeleton. Nucleus
Sequence: MNRYTTLKQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWEECMNLREVKSLKKLNHANVVKLKEVIRENDHLYFVFEYMKENLYQLMKDRTKLFPESVIRNISFQILQGLSFIHKHGFFHRDMKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSPVYSSPIDIWAVGCIMAELYTLRPLFPGNSEVDEIFKICQVLGTVKKSDWPEGHQLASAMNFRFPQCVPTPLKTLIPNATNEALDIMRDLLQWDPKKRPSAVKALRYPYFQVGQLLGPRPMTPDARKAPVKAVLPSELRSEMQSVSEPVLPSQTKGQSRNSHQPLQQIPLPQSLTQTDTVALHTQKVVGGENSLMGLKNGRRRWGQTNMKPSDSWDDSDCSDTAASLSKKPSKGPEEEKTTPQPKEQKPLYTFSTVTKLPNTSRLNQSDSSHQSTSSARQHYLRQSRYMPGLISKNTQSLGSKESQQDFWDTSALMSKPLAPIGGAPMSRISPGNFVTTTYNLSGGYIPSFQKKEVGSVGQRIQLAPLGHQHALDLSATADCKTGKAKPSKSKPSSTVSVNDNSEDYDGWKRRAERTQLKGTSYSALGKNSANLITHAPSVQPVHGRIDWAAKYGSHR
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [121-133]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1-285]
- IPR017441: Protein kinase, ATP binding site (binding_site) [10-33]
- IPR000719: Protein kinase domain (domain) [4-284]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [3-346]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0044087 (regulation of cellular component biogenesis), GO:0031344 (regulation of cell projection organization), GO:1902115 (regulation of organelle assembly), GO:0033043 (regulation of organelle organization), GO:0060491 (regulation of cell projection assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1902017 (regulation of cilium assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)
Protein: Tubulin polyglutamylase TTLL11 (Q08BJ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MSDHYERVKIELQQMKAVETEAAAEEEHLSPASSVPADVSFTALPRARRDLSRSSINGRSRSKSRGKADGHEKQVNGKHLSDVAPRKSDCSQEKGQNRVSNEQNLHIKGTGRLLKSKTAANGHVESCQRQTDEKCEHRGKEDGGKVAKKRRAVTVDTSKAKTSLEALKMSIRLLKWKEFPMGRRTACDIYWHGVSFHDNENIVSGQVNKFPGMIEMLRKINLSRAVRTMQEIYPEEYNFYPRSWILPEEYQLFCTQIRLLKDNDSILKPTFIVKPDSGSQGDGICLIRDPADLRVISGSQIKQSVVQEYIQKPLLIDKLKFDIRLYVLVRSLDPLEIYIAKEGLSRFCTEPYQEPSQKNLSHVFMHLTNYSLNVHSGNFVHSDSCSTGSKRTFSSVLYRLASKGVDIKKVWSDIIALVIKTVIALVPELKVYYQADIPPGKPGPTCFQILGFDILLMKNLKPVLLEVNANPSMRIEHEQEVSPGVYEYIPSPVDEEVKVGVIRDTLRLMDPAQRKHITSNAGGVSPEDAIVVETASDEKEGLADSLPSLCLKQVFPKYTKQFNYLRVVDRIATIFLRFLGVKGTMKLGPTGFRTFIRNCKLSNSSFSMASVDILYIDITRRWAGINPDSREAGMCLQAFIEAFFYLAARRFKASPLREQVLLLLEVCEVALEGQSPTDKPRPQKSHTNHGPMQPSAPNTFSSPALIRRRHQPLQISAKANTDN
InterPro domains: - IPR004344: Tubulin-tyrosine ligase/Tubulin polyglutamylase (family) [152-521]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0070739 (protein-glutamic acid ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity), GO:0070740 (tubulin-glutamic acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0007017 (microtubule-based process), GO:0044238 (primary metabolic process), GO:0007018 (microtubule-based movement), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0019538 (protein metabolic process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0030030 (cell projection organization), GO:0003341 (cilium movement), GO:0006996 (organelle organization), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0018193 (peptidyl-amino acid modification), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0018200 (peptidyl-glutamic acid modification), GO:0060271 (cilium assembly), GO:0018095 (protein polyglutamylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0043226 (organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium)
Protein: Zinc finger matrin-type protein 2 (Q6TLH9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in pre-mRNA splicing as a component of the spliceosome
Subcellular location: Nucleus
Sequence: MASGSGSKNDFRRKWDKDEYEQLAQKRITEEREKKDGKPVPPIKRELLRHRDYKVDLESKLGKTIVITKTTPQAEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSSLDQVKKRFEVNKKKLEEKQKEYDFEERMKELREEEEKAKAYRKEKQKEKKRKAEEDLNFEDDDEMAAVMGFSGFGSSKKGH
InterPro domains: - IPR003604: Matrin/U1-C-like, C2H2-type zinc finger (domain) [76-110]
- IPR040107: U4/U6.U5 small nuclear ribonucleoprotein component Snu23 (family) [1-196]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [74-119]
- IPR022755: Zinc finger, double-stranded RNA binding (domain) [79-104]
Interaction partners: - Spliceosome-associated factor 1, recruiter of U4/U6.U5 tri-snRNP
- Activating signal cointegrator 1 complex subunit 3
- Pre-mRNA-processing factor 6
- U6 snRNA-associated Sm-like protein LSm7
- U4/U6 small nuclear ribonucleoprotein Prp31
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm6
- Small nuclear ribonucleoprotein Sm D2
- U4/U6 small nuclear ribonucleoprotein Prp4
- Small nuclear ribonucleoprotein E
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005681 (spliceosomal complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0071011 (precatalytic spliceosome), GO:0005634 (nucleus)
Protein: Gamma-tubulin complex component 3 (B8A509)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Sequence: MATLDQKSPNVLLQSLCCKITGKSEADVAHQFQYAVRVIGSNYAPTIERDEFLVSEKIKKELLKQRREADAALFSELHRKLQTQGVLKHRWSILYLLLSLCEDPRKPSGRVPVCSYGALLAQALPRDVHSTPFYYARPQSLPLSYPERSATAHNSSMATSGISSMGVFSINGPGPTPPSLLTGSSMRGSRLAWTLPVSSSPSGAAAAPRPPSGPSSSPAPKPLQRPRRDGDGSADIGEAALVRDILYVFQGIDGKFIKMCSPENCYKIDSKVPLCKSLRDTSSRLAELGWLHNKIRKYTDSHSLDRAFGLVGQSFCAALHQELKEYYRLLSVLHAQLQVEDDQGVNMSVDSSLTLRRLLVWTYDPKVRLKTLAALVDYCQGRKGGELATAVHAYGKTGDPNMRALIQHILGLVSHPILNFLYRWIYDGELEDTYHEFFVASDPTVKTDRLWHDKYSLRKSMIPSFITMDQARKVLLIGKSINFLHQVCHDRTPPGKIMPASKSKDSPKDAAELFTDLEGTFQSKIDAAYFETSKYLLDVLNKNYQLLEHLQAMRRYLLLGQGDFIRHLMDLLKPELARPATTLYQHNLTGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVEGPIATVFTRECMSHYLRVFNFLWRAKRMEYILTDIWKGQMCNAKLLKSMPELSGVLHQCHVLASEMVHFIHQMQYYITFEVLECSWDELWNKVQQAQDLDHIIAAHDVFLDTIISRCLLDVNNRSLLNQLRAVFDQIIEFQNAQDTLYRSALEELQLRIQFEDKKRQREEMAEWGVTAEQEAEENRRVQEFKDTIPKMCSQLRLLTHFYQGIVQEFLRLLMTCSDESLQFLSFRLDFNEHYKARDPRLRPSLGATRGRRSSNI
InterPro domains: - IPR040457: Gamma tubulin complex component, C-terminal (domain) [546-877]
- IPR007259: Gamma-tubulin complex component protein (family) [60-878]
- IPR041470: Gamma tubulin complex component protein, N-terminal (domain) [242-542]
- IPR042241: Gamma-tubulin complex component, C-terminal domain superfamily (homologous_superfamily) [546-876]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0043015 (gamma-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0048793 (pronephros development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000930 (gamma-tubulin complex), GO:0042995 (cell projection), GO:0036064 (ciliary basal body), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Methyl-CpG binding protein 3a (Q7ZTV2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MERKSPTGKKFRSKPQLVRYLGKSMDLSSFDFRTGKMLMSKLNKNRQRIRSDHSQNKGKPDLNTSLPVRQTASIFKQPVTKVTNHPSNKVKTDPQKAVEQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGYSDKTLLSALASALHTSSAPITGQLSAAVEKNPGVWLNTTQPLCKSFMVTDEDIRKQEDLVFNVRKRLEEALMADMLAHIEEAAGDDKKPLSEDSAEEEMDTV
InterPro domains: - IPR025884: Methyl-CpG binding protein 2/3, C-terminal domain (domain) [120-210]
- IPR016177: DNA-binding domain superfamily (homologous_superfamily) [5-62]
- IPR032343: Methyl-CpG-binding domain protein 2/3, p55-binding region (domain) [51-115]
- IPR001739: Methyl-CpG DNA binding (domain) [1-44]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Atonal bHLH transcription factor 1c (A0A8M9Q9E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MPHPDTPFGQFIWRETDRSHSEQCPKAPMGWREEQLQDRASCDPCALVQLRLTGLSYSSEEQSSIARARRRRRLAANARERRRMLGLNVAFDRLRSVIPNVESDRKLSKSETLQMAQIYISTLSELLEDKDCDPETPYPTLTMQDQDITKGLPMTEETKTELKNNPTCRIRSYNGNFGCLTCSDHKTAELLVDSHCLERNNGVK
InterPro domains: - IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [66-134]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [71-129]
- IPR050359: Basic helix-loop-helix transcription factors (family) [59-152]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0045165 (cell fate commitment), GO:0048840 (otolith development), GO:0001709 (cell fate determination), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048839 (inner ear development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048663 (neuron fate commitment), GO:0008544 (epidermis development), GO:0007423 (sensory organ development), GO:0048664 (neuron fate determination), GO:0060113 (inner ear receptor cell differentiation), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0030855 (epithelial cell differentiation), GO:0042490 (mechanoreceptor differentiation), GO:0035315 (hair cell differentiation), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0043583 (ear development), GO:0042491 (inner ear auditory receptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Syntaphilin b (A0A8M9PQI7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass membrane protein
Sequence: MSSPSNKRSGSGSRKRSPAPVSNRDPYGNASLSSSSNSGSCKGSDGSPTHRRHIKYTSCNDNHGIRPPPPEQYLTPLQQKEVCIRHLRARLKETIERLQDRDSEIDELRTQLTRMQEDWIEEECHRVEAQLALKEARREIHQLKEVVDVVKSSLGDTDTGVQKGFQDINLQNHKLESLLQSMELAQIGTTKTGEALAGGGLVGAGLEVSEGLAGSSEGSPARSLTRSSTYTKLSDQGGPERESNENGCDIPCLSGEGTQDSGFVCCGESGRGASKADLLLEAAFLSQETASLLNAYSRLPHSSTYEGLCSSEPRVVPLRCSSIGAGASVSLSHPCLSHHHLYLHHLREQGIQTEYDHAPASAPAHGPSTSFNSDLDTIAERTFRSQACSPTSTWMSDEGDDLESAATESAITATVATTSVVADFSTKSAPVAMGNWMPTASDSKGAATFPLMPIDSPDKETSFSEPLTDLPISTTALTTETIGSPVTNSTVQPQPITDPLPNPGTSPCSMQPLVGTEEDSLPQTTQPHSVLTETVVPGDNVINIGADDEDEGDEGATNTDSKSSGCGLPVKNYWSRHFLVDLLAVVVPVVPTVAWFCRGPHRDGQPIYHIGSLLRGCCTVALHSLRRGGGLRHYPAGGGGPGGMNI
InterPro domains: - IPR028197: Syntaphilin/Syntabulin (family) [19-282]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0009799 (specification of symmetry), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0009855 (determination of bilateral symmetry), GO:0009953 (dorsal/ventral pattern formation), GO:0030111 (regulation of Wnt signaling pathway), GO:0048262 (determination of dorsal/ventral asymmetry), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0048263 (determination of dorsal identity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)
Protein: Lactoylglutathione lyase (Q6P696)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis
Sequence: MTDQGVTNEAAAAACKEGSSITKDFMMQQTMLRVKDPVKSLDFYTRILGMTLLQKFDFPSMRFTLYFLGYEDKKEIPADVKERTAWTFSRRATIELTHNWGSETDDSQSYHNGNSDPRGFGHIGIAVPDVYAACKLFEENGVTFVKKPDEGKMKGLAFIQDPDGYWIEILSPNNMVSITS
InterPro domains: - IPR018146: Glyoxalase I, conserved site (conserved_site) [29-129]
- IPR004361: Glyoxalase I (family) [27-173]
- IPR029068: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (homologous_superfamily) [1-179]
- IPR004360: Glyoxalase/fosfomycin resistance/dioxygenase domain (domain) [29-169]
- IPR037523: Vicinal oxygen chelate (VOC), core domain (domain) [26-172]
Interaction partners: - Hydroxyacylglutathione hydrolase, mitochondrial
- Glyoxylate reductase/hydroxypyruvate reductase
- S-formylglutathione hydrolase
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
- L-serine ammonia-lyase
- Aldo-keto reductase family 1 member A1-B
- Amine oxidase [flavin-containing]
- Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
- Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
- Aldo-keto reductase family 1 member A1-A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016846 (carbon-sulfur lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0046626 (regulation of insulin receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)