Protein: CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83) (Q01151)
Organism: Homo sapiens (Human)
Function: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKLLEGGEERMETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSGKVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGMERAFLPVTSPNKHLGLVTPHKTELV
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [22-127]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [21-131]
- IPR007110: Immunoglobulin-like domain (domain) [18-119]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [17-138]
- IPR003599: Immunoglobulin domain subtype (domain) [20-127]
Interaction partners: - T-cell surface glycoprotein CD1b
- Tumor necrosis factor receptor superfamily member 5
- T-cell surface glycoprotein CD1c
- T-lymphocyte activation antigen CD86
- Tumor necrosis factor
- T-cell surface glycoprotein CD1e, membrane-associated
- Antigen-presenting glycoprotein CD1d
- T-lymphocyte activation antigen CD80
- T-cell surface glycoprotein CD1a
- C-C chemokine receptor type 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:1903706 (regulation of hemopoiesis), GO:0001817 (regulation of cytokine production), GO:0046649 (lymphocyte activation), GO:0050867 (positive regulation of cell activation), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:0001818 (negative regulation of cytokine production), GO:0001819 (positive regulation of cytokine production), GO:1903708 (positive regulation of hemopoiesis), GO:0050865 (regulation of cell activation), GO:0030097 (hemopoiesis), GO:0032743 (positive regulation of interleukin-2 production), GO:0032733 (positive regulation of interleukin-10 production), GO:0002521 (leukocyte differentiation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0032663 (regulation of interleukin-2 production), GO:0022407 (regulation of cell-cell adhesion), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0010628 (positive regulation of gene expression), GO:0032673 (regulation of interleukin-4 production), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0051251 (positive regulation of lymphocyte activation), GO:1902107 (positive regulation of leukocyte differentiation), GO:0042110 (T cell activation), GO:1902105 (regulation of leukocyte differentiation), GO:0032653 (regulation of interleukin-10 production), GO:0014070 (response to organic cyclic compound), GO:0010629 (negative regulation of gene expression), GO:0051249 (regulation of lymphocyte activation), GO:0050870 (positive regulation of T cell activation), GO:0045619 (regulation of lymphocyte differentiation), GO:0050863 (regulation of T cell activation), GO:0030217 (T cell differentiation), GO:0045621 (positive regulation of lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0046631 (alpha-beta T cell activation), GO:0035710 (CD4-positive, alpha-beta T cell activation), GO:0046632 (alpha-beta T cell differentiation), GO:0046635 (positive regulation of alpha-beta T cell activation), GO:0045582 (positive regulation of T cell differentiation), GO:0046634 (regulation of alpha-beta T cell activation), GO:0045580 (regulation of T cell differentiation), GO:0046637 (regulation of alpha-beta T cell differentiation), GO:2000516 (positive regulation of CD4-positive, alpha-beta T cell activation), GO:0046638 (positive regulation of alpha-beta T cell differentiation), GO:2000514 (regulation of CD4-positive, alpha-beta T cell activation), GO:0043367 (CD4-positive, alpha-beta T cell differentiation), GO:0043370 (regulation of CD4-positive, alpha-beta T cell differentiation), GO:0043372 (positive regulation of CD4-positive, alpha-beta T cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)