Protein: Galactokinase (EC 2.7.1.6) (Galactose kinase) (P96993)
Organism: Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Function: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00246}.
Sequence: MKKQELNQAFTHVFGREADATFFSPGRINLIGEHTDYNGGRVFPAAITLGTYGAARKRDDKLLRFYSANFEELGIIEISLDHLIFNKKDSWTNYPKGVIKYLQEAGHSIDTGMDVYVFGNIPNGSGLSSSSSLELLIGIMAEELFDLKLDRLDLVKIGKRTENDFIGVNSGIMDQFAIGMGAEKKAIYLDTKTLEYDLVPLDLGDNVIVIMNTNKRRELADSKYNERRTECEKAVEELNVLLDIKSLGELDEETFDEYAYLIKDAKRIKRARHAVSENQRTLKAKKALAAGDLEKFGRLVNASHVSLEHDYEVTGIELDTLAHTAWEQEGVLGARMTGAGFGGCGIAIVAKDKVAALKENVGRIYTETVGYAPAFYIAEIAGGSRVLSRK
InterPro domains: - IPR013750: GHMP kinase, C-terminal domain (domain) [285-362]
- IPR006206: Mevalonate/galactokinase (family) [1-388]
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [2-208]
- IPR022963: Galactokinase, bacterial (family) [24-386]
- IPR006203: GHMP kinase, ATP-binding, conserved site (conserved_site) [121-132]
- IPR000705: Galactokinase (family) [4-385]
- IPR006204: GHMP kinase N-terminal domain (domain) [93-181]
- IPR019539: Galactokinase, N-terminal domain (domain) [8-57]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [4-203]
- IPR019741: Galactokinase, conserved site (conserved_site) [26-37]
- IPR036554: GHMP kinase, C-terminal domain superfamily (homologous_superfamily) [206-386]
Interaction partners: - Galactose-1-phosphate uridylyltransferase
- UDP-glucose 4-epimerase
- Galactose operon repressor GalR
- Uncharacterized protein
- Galactose-6-phosphate isomerase subunit LacA
- Tagatose 1,6-diphosphate aldolase 1
- Galactose-6-phosphate isomerase subunit LacB
- UDP-glucose 4-epimerase
- Tagatose-6-phosphate kinase
- Alpha-galactosidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0048029 (monosaccharide binding), GO:1901265 (nucleoside phosphate binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0043169 (cation binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0005534 (galactose binding), GO:0032555 (purine ribonucleotide binding), GO:0046872 (metal ion binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0000287 (magnesium ion binding), GO:0019200 (carbohydrate kinase activity), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0005975 (carbohydrate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)