Protein: Glycogen phosphorylase, brain form (EC 2.4.1.1) (P11216)
Organism: Homo sapiens (Human)
Function: Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Sequence: MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRHLHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNLGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEIVKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEYAREIWGVEPSDLQIPPPNIPRD
InterPro domains: - IPR000811: Glycosyl transferase, family 35 (family) [6-839]
- IPR011833: Glycogen/starch/alpha-glucan phosphorylase (family) [25-828]
- IPR035090: Phosphorylase pyridoxal-phosphate attachment site (conserved_site) [673-685]
Interaction partners: - Glycogen debranching enzyme
- 1,4-alpha-glucan-branching enzyme
- UTP--glucose-1-phosphate uridylyltransferase
- Glycogen phosphorylase, liver form
- Pancreatic alpha-amylase
- Alpha-amylase 2B
- demerged
- Maltase-glucoamylase
- Phosphopentomutase
- Glycogen [starch] synthase, liver
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0004645 (1,4-alpha-oligoglucan phosphorylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044248 (cellular catabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009057 (macromolecule catabolic process), GO:0005976 (polysaccharide metabolic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0016052 (carbohydrate catabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0000272 (polysaccharide catabolic process), GO:0006073 (cellular glucan metabolic process), GO:0044042 (glucan metabolic process), GO:0006112 (energy reserve metabolic process), GO:0044247 (cellular polysaccharide catabolic process), GO:0005977 (glycogen metabolic process), GO:0005980 (glycogen catabolic process), GO:0009251 (glucan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)