Protein: Histone-lysine N-methyltransferase SUV39H1-A (Q6DGD3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as regulation of organ-specific terminal differentiation during development
Subcellular location: Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin
Sequence: MARDLKDCRVPCKLLLEDLQALCRRKKLVCKQLSVTKNNFNDYEVEYLCNYKKHKGREFFLVKWKGYEESENTWEPLKNLKCPILLHQFRKDMKAALLQANEPLDSASLSGPIISFLRQKATQRIRLKKWEDLMNQTCWHKGRIFVSNEVDMDGPPKNFTYINENKLGKGVDMNAVIVGCECEDCVSQPVDGCCPGLLKFRRAYNESRRVKVMPGVPIYECNSKCRCGPDCANRVVQRGIQYDLCIFKTDNGRGWGVRTLQRINKNSFVMEYLGEIITTDEAEQRGVLYDKQGVTYLFDLDYVDDVYTIDAAHYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFAKRGIKAGEELTFDYKMTVDPVDAESTKMDLDFSRAGIEGSPIKRVHMECKCGVRNCRKYLF
InterPro domains: - IPR016197: Chromo-like domain superfamily (homologous_superfamily) [30-92]
- IPR023780: Chromo domain (domain) [43-91]
- IPR007728: Pre-SET domain (domain) [131-239]
- IPR046341: SET domain superfamily (homologous_superfamily) [122-368]
- IPR000953: Chromo/chromo shadow domain (domain) [42-101]
- IPR050973: Histone-lysine N-methyltransferase, H3 Lys-9 specific (family) [3-411]
- IPR011381: Histone-lysine N-methyltransferase SUV39H1/2-like (family) [1-411]
- IPR023779: Chromo domain, conserved site (conserved_site) [60-80]
- IPR003616: Post-SET domain (domain) [395-411]
- IPR001214: SET domain (domain) [242-371]
Interaction partners: - Histone H3
- Histone H3.2
- Histone H3.3
- Histone H3
- DNA (cytosine-5)-methyltransferase
- Lysine-specific histone demethylase
- Histone-lysine N-methyltransferase KMT5B
- Chromodomain Y-like protein
- Lysine-specific demethylase phf2
- Histone-lysine N-methyltransferase SETD7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity), GO:0042800 (histone H3K4 methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009887 (animal organ morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0043414 (macromolecule methylation), GO:0044260 (cellular macromolecule metabolic process), GO:0060041 (retina development in camera-type eye), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0055123 (digestive system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0031016 (pancreas development), GO:0031017 (exocrine pancreas development), GO:0008213 (protein alkylation), GO:0048592 (eye morphogenesis), GO:0018022 (peptidyl-lysine methylation), GO:0001654 (eye development), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0150063 (visual system development), GO:0034968 (histone lysine methylation), GO:0061647 (histone H3-K9 modification), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0018205 (peptidyl-lysine modification), GO:0051567 (histone H3-K9 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0000792 (heterochromatin), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)