Protein: Eukaryotic translation initiation factor 2 subunit 2 (P20042)
Organism: Homo sapiens (Human)
Function: Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity)
Subcellular location: Cytoplasm, cytosol
Sequence: MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN
InterPro domains: - IPR045196: Translation initiation factor IF2/IF5 (family) [177-327]
- IPR016189: Translation initiation factor IF2/IF5, N-terminal (homologous_superfamily) [173-281]
- IPR002735: Translation initiation factor IF2/IF5 domain (domain) [197-308]
- IPR016190: Translation initiation factor IF2/IF5, zinc-binding (homologous_superfamily) [279-313]
Interaction partners: - Eukaryotic translation initiation factor 2 subunit 1
- Translation initiation factor eIF2B subunit alpha
- Eukaryotic translation initiation factor 2 subunit 3
- Translation initiation factor eIF2B subunit beta
- Eukaryotic translation initiation factor 5
- Translation initiation factor eIF2B subunit gamma
- Translation initiation factor eIF2B subunit epsilon
- Eukaryotic translation initiation factor 1
- Eukaryotic translation initiation factor 3 subunit C
- Eukaryotic translation initiation factor 3 subunit B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0051128 (regulation of cellular component organization), GO:0030100 (regulation of endocytosis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)