Protein: Cell surface superoxide dismutase [Cu-Zn] 4 (EC 1.15.1.1) (GPI-anchored protein 2) (Q5AD05)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:15302828}. Membrane {ECO:0000305|PubMed:15302828}; Lipid-anchor, GPI-anchor. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP). {ECO:0000269|PubMed:15302828}.
Sequence: MKYLSIISIVALALAGDSPISTDSKGKAPLVARFKKTSKSDIEGTIKFEPANNGTVLVSVDLTGLPSGVGPYPYHVHEKPVPESKNCTATGMHFNPFNGSTTAKTPAALELGDLSGRHGNITSESFEVEYDDSYISLNKDSKAYIGGLSIVVHSNNNTRLNCANITTLDEGDDTASAATWSNSSSSSSSSSKNSTNGSSGSSTSASQGSGAGRAEISGFLAAGIAGVVAALI
InterPro domains: - IPR001424: Superoxide dismutase, copper/zinc binding domain (domain) [43-159]
- IPR036423: Superoxide dismutase-like, copper/zinc binding domain superfamily (homologous_superfamily) [26-181]
- IPR024134: Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone (family) [30-227]
Interaction partners: - Superoxide dismutase 1 copper chaperone
- Peroxisomal catalase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004784 (superoxide dismutase activity), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0043169 (cation binding), GO:0016721 (oxidoreductase activity, acting on superoxide radicals as acceptor), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0051701 (biological process involved in interaction with host), GO:0010035 (response to inorganic substance), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0006979 (response to oxidative stress), GO:0072593 (reactive oxygen species metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0075136 (response to host), GO:1901700 (response to oxygen-containing compound), GO:0034599 (cellular response to oxidative stress), GO:0052200 (response to host defenses), GO:0062197 (cellular response to chemical stress), GO:0006801 (superoxide metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0000305 (response to oxygen radical), GO:0000303 (response to superoxide), GO:0052572 (response to host immune response), GO:0034614 (cellular response to reactive oxygen species), GO:0071450 (cellular response to oxygen radical), GO:0042783 (evasion of host immune response), GO:0071451 (cellular response to superoxide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall)