Protein: Caspase-3 (A0A2R8QUC0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MNGDCVDAKRVDTTDASKDGASASQPMQVDAKPQSHAFRYSLNYPNIGHCIIINNKNFDRRTGMNPRNGTDVDAGNVMNVFRKLGYIVKVYNDQTVAQIMQVLTTVAHDDHSRCASLVCVLLSHGDEGVFFGTDTSVDLKSLTSLFRGDRCPSLVGKPKLFFIQACRGTELDPGVETDHPDHPDIPDGRVRIPVEADFLYAYSTVPGYYSWRNTMTGSWFIQSLCEMMTKYGSELELLQIMTRVNHKVALDFESTSNMPGFDAKKQIPCIVSMLTKEMYFTP
InterPro domains: - IPR002398: Peptidase C14 family (family) [8-280]
- IPR033139: Peptidase family C14A, cysteine active site (active_site) [157-168]
- IPR001309: Peptidase C14, p20 domain (domain) [46-170]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [35-282]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [39-282]
- IPR011600: Peptidase C14, caspase domain (domain) [48-279]
- IPR016129: Peptidase family C14A, His active site (active_site) [111-125]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [188-282]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0010941 (regulation of cell death), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0001558 (regulation of cell growth), GO:0046677 (response to antibiotic), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0010033 (response to organic substance), GO:0048638 (regulation of developmental growth), GO:0061387 (regulation of extent of cell growth), GO:0032535 (regulation of cellular component size), GO:0050770 (regulation of axonogenesis), GO:0071466 (cellular response to xenobiotic stimulus), GO:0071236 (cellular response to antibiotic), GO:0031344 (regulation of cell projection organization), GO:0048670 (regulation of collateral sprouting), GO:0043067 (regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043068 (positive regulation of programmed cell death), GO:0033993 (response to lipid), GO:0006915 (apoptotic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0032526 (response to retinoic acid), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0071300 (cellular response to retinoic acid), GO:0008361 (regulation of cell size), GO:0071396 (cellular response to lipid), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)