Protein: EF-hand domain-containing family member B (Cilia- and flagella-associated protein 21) (F1MMV1)
Organism: Bos taurus (Bovine)
Function: Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion and the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37327785}. Cytoplasm {ECO:0000250|UniProtKB:Q8N7U6}.
Sequence: MCSFLRVPSPKGLEPSKGLGAPLQPGTAYPSEMSALGPGMTVSGRKSPLSMEVGLAPEGKDDLEERRVFMGTTSPTELGLRVGLRKDFPCSKTYEERMASPEIRSPSSKGLELRLKRQNISRTVMDGSNLGVHRVSASQETKPPLSALPGRVGLEKERFLAGYCPGRVTQPPLGQGCESPQASGGRRCPVTGDPEGFGASVSKLPALGMECRGELGGESACVVMKPRAETEPPVEVDMGLTRLEEPAEMESPEPQMGLVMEPPAWQLAQQPEEQREAENTEPGVEPPDRIRPIYSGKFFDRMPCWPSAGKVLPIGYRAATCLTERFPRLMTPPEAKKFFNFRYPPAGAERVFYGRANDPQIAPSLTHGIRSKISIPAKVLINPQPITTFQQKMKDKKESVYFSNQRAPLGKSHDQTPGLPKGLDILNTTFGTAIVRETSARDMVNPPKPYKEVFEEAQAGHDLYVVSHNDYFVGEAKNRKYDPSSFHRFNLYGIPTPHFNDGRNMAKTLHWLHELQMKRGAKIVSKRVDDFKEKFQHRLGRVLDPIAETMNVPPDYTFGAFLRPEDYGVGDLIHRRLPGEYLRGKDRQRGLVAAVRHHLKKVNYQNFDTLLAAFRHYDKKGDGVIDRAELQEACDQACLHLDEKLLDQLFEYCDVDKDGLINYLEFANFLTWKDKTPLKEYEERVLIKGRKADCANPAEANVEESEPALLLKPEDIVLKEPGSSEKTLRTLLRPSDKVSNHYKTTSSEISAVVGAVPSTCYPTYGVPTIRSDIPAPLIRRVSDRTSYGEEGNAYSLLHPTIFAQKGVFERDFFKTRSKQEISEILCNIGVKLSEDEFENVWNLASKKHHRGEVCVENIRSVLDELQHADGAKCKAAT
InterPro domains: - IPR040193: EF-hand domain-containing protein EFHC1/EFHC2/EFHB (family) [291-875]
- IPR011992: EF-hand domain pair (homologous_superfamily) [597-860]
- IPR057428: EFHB, C-terminal EF-hand domain (domain) [794-867]
- IPR002048: EF-hand domain (domain) [605-676]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [654-666]
Interaction partners: - WD_REPEATS_REGION domain-containing protein.
- Cilia- and flagella-associated protein 107
- Tektin-3
- Meiosis-specific nuclear structural protein 1
- Tektin-1
- Tektin-4
- RIB43A-like with coiled-coils protein 2
- Tektin-2
- Protein Flattop
- Cilia- and flagella-associated protein 52
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0005879 (axonemal microtubule), GO:0005881 (cytoplasmic microtubule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0097014 (ciliary plasm), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)