Protein: Ceramide phosphoethanolamine synthase (CPE synthase) (EC 2.7.8.48) (O77475)
Organism: Drosophila melanogaster (Fruit fly)
Function: Catalyzes the biosynthesis of ceramide phosphoethanolamine (CPE) through the transfer of a phosphatidyl head group from cytidine 5'-diphosphate (CDP)-ethanolamine on to the primary hydroxyl of ceramide.
Subcellular location: Membrane {ECO:0000269|PubMed:23449981}; Multi-pass membrane protein {ECO:0000269|PubMed:23449981}. Golgi apparatus membrane {ECO:0000269|PubMed:23449981}. Cell membrane {ECO:0000269|PubMed:23449981}. Note=The majority of protein localizes to the Golgi apparatus. {ECO:0000269|PubMed:23449981}.
Sequence: MIGPSSQISKILLTLLFLLIIFYVFMDVELYLRIHNYAIERNYHTNVSLPASVVGPSTSESGSGSIGGSSSSSSSSSSSTSTKLPTAGDRQPSYEDHTWISCDINPLCHVTVKAILLDHTNHYLFAPLATMFDNVIGFSRSTFITPNMISFFHVGVACLAGKLVASDSLGYRRLGVLLFQIRTFLDDLDGHVARVRKHIRGERSEIGTSGYYVDGLCDGLGCIALLLGIFFYLKNNPPRRGYSIIPMSDSKLPEPTMMIPKMKATTRKVAKNVISFTGQLLLSSTAWNRYIAVYQNMLEREDVSGNQSHCQDYVFKSTWFFCVAWMWRIVNVHALLHCVLLSIFCDKLWDFLRAIRYSGYIILLVAICLTEMHILEAQNYIFNSTACSNISL
InterPro domains: - IPR043130: CDP-alcohol phosphatidyltransferase, transmembrane domain (homologous_superfamily) [118-297]
Interaction partners: - LD47749p
- U3 small nucleolar ribonucleoprotein protein IMP3
- Bystin
- ATP-dependent RNA helicase DHX15 homolog
- Pre-mRNA-processing factor 17
- Cell division cycle 5, isoform A
- Pre-mRNA-splicing factor syf1 homolog
- Protein crooked neck
- Eukaryotic initiation factor 4A-III
- LD31322p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016780 (phosphotransferase activity, for other substituted phosphate groups), GO:0017169 (CDP-alcohol phosphatidyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0018904 (ether metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006662 (glycerol ether metabolic process), GO:1901503 (ether biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0046504 (glycerol ether biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0097384 (cellular lipid biosynthetic process), GO:0046485 (ether lipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0008611 (ether lipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)