Protein: DNA ligase (EC 6.5.1.1) (F1Q9E8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MESVSKSDAKPQAFVAAQVPFIHLCTVLEKIQKTKLRPDKSKILKEFIDSWRNFHAALHKDNPDTADSFYAVMRLIVPSFERERMAYGIKENMLAKLYIEVLGLPKNGDEANKLLNYRAPTTSQGEAGDFALMAYFVLKKRCTSQGNLSIKEVNDFLDSVAINNASKQKDQVKKSLLHLITQSSALEQKWLIRMILKDMKLGISKETVLQVFHPDAPEFYNVTTDLNKVCRQLHDPSVSLSEVSIDLFSAFKPMLAAVANIRQIEKQMGNRPFYIETKLDGERIQLHKAGDVYKYYTRNSYEYTQQFGASPLEGSLTPYIHNVFSPHVVNCILDGEMMAYNPKTETFMQKGSKFDIKRLVDDSDLQTCFCVFDVLLINNQKFGKEPLKKRYESLETVFSPIKGRIHLVSKSEGRTMQEVVNSLNEAIDNREEGIMVKDPMSIYKPDKRGEGWLKIKPEYVDGLMDELDLLIVGGYWGKGRRSGMLSHFLCAVAEVPSPGEKPTVFHTLCRIGSGYTLKELYDLGVKLAKHWKVYNKNNPPAAILCGTEKPEVYIEPRNSVILQVKAAEIVTSEMYKTDCTLRFPRIERIREDKEWHQCMTLDDLNQFRSKASGKLASRHLNIHEDQPEKKKRKIVAKPKKTIGVIDHFKSQDLSKVAKETDMFEEVEFCVINGDDEHSKAELEKGVARCGGIVVQNPGKDTYCAIAAVQNMRVKNLISSDQHDVVWATWLLECLENKQVIPWQPRHMIHMSPSTREHFAKEYDQYGDSYYVDTSEQQLRDVIERISSAEVKSLSVAQIEAENAWDDLPTSIFRPYSAYFDRCADIGDPKSVICGTCLDTRALEFRFHGGKVVEKLKEGISHVVVEDMKRALDLKTLRRLHAKKFKIVHESWVTDSIKAGHVKDEIDYLI
InterPro domains: - IPR012308: DNA ligase, ATP-dependent, N-terminal (domain) [20-213]
- IPR012310: DNA ligase, ATP-dependent, central (domain) [253-494]
- IPR021536: DNA ligase IV domain (domain) [754-786]
- IPR036599: DNA ligase, ATP-dependent, N-terminal domain superfamily (homologous_superfamily) [8-259]
- IPR016059: DNA ligase, ATP-dependent, conserved site (conserved_site) [276-456]
- IPR044125: DNA Ligase 4, adenylation domain (domain) [240-461]
- IPR029710: DNA ligase 4 (family) [10-908]
- IPR012309: DNA ligase, ATP-dependent, C-terminal (domain) [481-593]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [630-909]
- IPR001357: BRCT domain (domain) [658-909]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [459-614]
- IPR000977: DNA ligase, ATP-dependent (family) [86-604]
Interaction partners: - DNA helicase
- X-ray repair cross-complementing protein 5
- Non-homologous end-joining factor 1
- DNA-dependent protein kinase catalytic subunit
- DNA repair protein XRCC4
- DNA repair protein RAD52 homolog
- DNA repair protein XRCC1
- Exonuclease 1
- Protein artemis
- Excision repair cross-complementation group 4.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0005515 (protein binding), GO:0016886 (ligase activity, forming phosphoric ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0003909 (DNA ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006302 (double-strand break repair), GO:0006303 (double-strand break repair via nonhomologous end joining)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)