Protein: ATP-binding cassette sub-family G member 8 (EC 7.6.2.-) (Sterolin-2) (P58428)
Organism: Rattus norvegicus (Rat)
Function: ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H221}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H221}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H221}.
Sequence: MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQGGTCLRSWGQEDPHMSLGLSESVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVPGDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW
InterPro domains: - IPR013525: ABC-2 type transporter, transmembrane domain (domain) [418-629]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [235-249]
- IPR043926: ABC transporter family G domain (domain) [292-356]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [106-334]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [91-335]
- IPR050352: ATP-binding cassette subfamily G transporters (family) [34-648]
Interaction partners: - ATP-binding cassette sub-family G member 5
- NPC1-like intracellular cholesterol transporter 1
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Cytochrome P450 7A1
- Sterol regulatory element-binding protein 2
- ABC-type oligopeptide transporter ABCB9
- Oxysterols receptor LXR-alpha
- Scavenger receptor class B member 1
- Hepatic sodium/bile acid cotransporter
- Sodium/potassium-transporting ATPase subunit alpha-4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0022804 (active transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0042910 (xenobiotic transmembrane transporter activity), GO:0008092 (cytoskeletal protein binding), GO:0015562 (efflux transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0034097 (response to cytokine), GO:0071310 (cellular response to organic substance), GO:0019221 (cytokine-mediated signaling pathway), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0048856 (anatomical structure development), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031968 (organelle outer membrane), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)