Protein: Glutamate receptor ionotropic, delta-2 (GluD2) (GluR delta-2 subunit) (Q61625)
Organism: Mus musculus (Mouse)
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex.
Subcellular location: Postsynaptic cell membrane {ECO:0000305|PubMed:24357660}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MEVFPLLLFLSFCWSRTWDLATADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFAFGSVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI
InterPro domains: - IPR001508: Ionotropic glutamate receptor, metazoa (family) [484-855]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [442-842]
- IPR015683: Ionotropic glutamate receptor (family) [29-869]
- IPR001828: Receptor, ligand binding region (domain) [42-404]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [442-551]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [21-426]
Interaction partners: - Cerebellin-1
- Neurexin-1
- Neurexin-3
- Delphilin
- Neurexin-2
- Glutamate receptor 1
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, kainate 2
- Glutamate receptor ionotropic, NMDA 2B
- Glutamate receptor 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0007610 (behavior), GO:0035176 (social behavior), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0050807 (regulation of synapse organization), GO:0099175 (regulation of postsynapse organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0098984 (neuron to neuron synapse), GO:0098982 (GABA-ergic synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane)