Protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) (InsP6 and PP-IP5 kinase) (P91309)
Organism: Caenorhabditis elegans
Function: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6PFW1}.
Sequence: MAHKGTESKEQIWPYKITIGICAMNRKATSKPMRAIMKKIIDFYGQWVDSFIFPEQVIINEPVENWPLCHCLVSFHSTEFPLEKAIAYVKLRNPYVINNLDRQYDLLDRRTVFKILSDNGIEHPRHGYVIRGRPNEPDTELVEHPDHIEVNGEVFNKPFVEKPISSEDHNVYIYYPSSVGGGSQRLFRKINNRSSWYSPKSEVRKEGSYIYEEFIPADGTDVKVYAVGPFYAHAEARKAPGLDGKVERDSDGKEVRYPVILSNKEKQIAKKIVLAFGQTVCGFDLLRANGKSYVCDVNGFSFVKTSTKYYEDTAKILGNQIVRHYAKSKNWRVPSDMPQPPILDLGLGDDPPMITTPSGKLAELRCVVAVIRHGDRTPKQKMKLIVTDQRFFALFEKYDGYKKHEIKMKKPNQLMEVLELARALVIEKQRDRHQILEKLREGTGEEEIHKSEHDLEVCEEEMKKWEQMRTVLEMYGHFSGINRKVQMKYLKERETKTSDEELRREGPALLLILKWGGELTTAGNMQAEALGRLFRTLYPGIRRTDGKSSPEDTQGLGFLRLHSTYRHDLKIYASDEGRVQTTAAAFAKGLLALEGELTPILMQMVKSANTDGLLDDDCQARLYQTELKRYLHKALQADRDFTPQDYLELNPNGLRAITAAMEFIKNPRKMCHEIAGYVEKMCGVIVEYSQTRPTGSTLYLQESMDLAQRRWNKELREFRRKNKHGEVEFDISKIPDIYDNIKYDMEHNPDLCINNEVEFERMYVCVKNMADIVVPQEYGIKTENKMVIAQRVCTPLLRKIRNDLHRCLENKESEETQTRLDPRASQGIATPFRHVRTRLYFTSESHIHTLMNLIRYGNLCSVDDKKWQRAMNFLSGVTEFNYMTQVVLMVYEDSRKENDEADTGPRFHIEILFSPGLYPCFLTEKERIYETRFNLSTNPKPATSSRSSGRESRDTNDSASSSTEGRRPSIEKVVTVVTPTQLSTPSVTNDDLSISSNAESTAAESTGLVNTTTKTHNDSEDDLNDVESVNLVALDELNNTTKAMADDGKTAKRQRSVTGAEKSMEEGDKPHGEWKGNGVAKSGSQISVGSNEMESNNESMETVGGGKGQWVKDLLDQTKRAMAMNSIREVEPPIVIPTPVPSTTTAVVEDEASERQSRSRRYFPYRFKHHTAQLLTGMSGGGVHMQNRLISTDVLTGKFGDHDNKKNSRKDFGAGTAVLSTAVIARSSSAPRLMTYESEDFSVGEIKRFWPPLRSLETLHDSINLSQFDGFLERLIKGALTPLPSPPKTPLPSALSCDAINKTPTQDEVEKVIGKLAPTSSTD
InterPro domains: - IPR040557: VIP1, N-terminal (domain) [17-108]
- IPR000560: Histidine phosphatase superfamily, clade-2 (family) [363-913]
- IPR037446: Histidine acid phosphatase, VIP1 family (family) [6-1280]
- IPR029033: Histidine phosphatase superfamily (homologous_superfamily) [357-920]
- IPR033379: Histidine acid phosphatase active site (active_site) [364-378]
Interaction partners: - Kinase
- Putative inositol monophosphatase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016776 (phosphotransferase activity, phosphate group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0043647 (inositol phosphate metabolic process), GO:0019751 (polyol metabolic process), GO:0006796 (phosphate-containing compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)