wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Rifin (Q8I4N6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MKIHYINILLFPLKLNILIYNQRNHKSTTHHTLKIPITRLLCECELYTPANYDNDPQMKEVMDNFNRQTQQRFHEYDERMVEKRMQCKDKCDKEIQKIILKDKLEKQMEQQLTTLETKITTDDIPTCLCEKSVADKMEKTCLRCAGVLGGGVMPGMGLIDGSLLGAISVLKPAAIIAAKDAALAEATALATQAGMREVVLKIEQFLKLFSEKEKIFDLKLIVNKSNFSCGSSLFQNAKELANKSCVAKPNGSYTSFCNSITYSRVEPFNGYAQAGITKYNETLPLQKALLEKAKVDAVNTTYAAYHTSIIASIVAVVVIVLIMVIIYLILRYRRKKKMKKKLQYIKLLEE
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [56-131]
- IPR006373: Variant surface antigen Rifin (family) [1-350]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033644 (host cell membrane), GO:0020002 (host cell plasma membrane)
Protein: Coiled-coil domain-containing 28B (Coiled-coil domain-containing protein 28B) (B8A4M8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MEDKRKKRSPKVSLPQPPPPPINPRKLTVLPASKSATFSLGLPQPPSPKPRGKYKRSVGAMGPSKEALAVPVVPPKNTRPHREKPRAPQPAGPSRVSQSSSPLQHTFLTDVSDVREMEGGLLNLLNDFHSGKLQAFGKVCSFEQLEHVREMQERLARLHFSLDSHVEELSEDQRKNASDRNLEHLLSNLEELSTSIQKLHLAENQDLPKTSNT
InterPro domains: - IPR025271: Coiled-coil domain-containing protein 28 (family) [1-211]
Interaction partners: - Bardet-Biedl syndrome 1.
- Bardet-Biedl syndrome 10.
- Bardet-Biedl syndrome 12
- Bardet-Biedl syndrome 7 protein homolog
- BBSome complex member BBS2
- Reticulon 4 receptor-like 1a.
- MKS transition zone complex subunit 1
- Tetratricopeptide repeat domain 8.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0036064 (ciliary basal body), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: ethanolamine kinase (EC 2.7.1.82) (Q386V0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MEVAVGHVRHVPCTVPDDPASRMRAIREIVARHCALFMQKGGDVGRSQCASNLGNNITSGTSNGFDADRLQVVAFSGGITNEMYHVYCEGWEAHSVVMRIFGKETERVISRGDELFYQSLFIPTYVRGQNFLVYQYLYQYEPLPFVEMVKEYEKIARGIAFFHVRATLEARSDYSVTPVGGVVGAGGATVGPTNTCSRFDLEENYIVHSLTEWVEQALSETVQEKVDATKRATYASVAQQLKEEAQWLLPLMQRHSPELGESTCHNDLLSGNIMRQKSDGALKIIDFEYAKRNYFLFDIANHFNEYTGLECDYATYFPSEEHMKKFVTTYMCAMREELEKHAEEAKRRQLTDIIPGQQHFFMCDVGGVEGDKRIHRMVQLVKLLTLASHLSWSVWALLQEAVSKTDMDFLRYSQLRLSRYLETRKEFSASS
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [65-427]
Interaction partners: - Choline/ethanolamine kinase, putative
- Ethanolamine-phosphate cytidylyltransferase
- Uncharacterized protein
- Raptor N-terminal CASPase-like domain-containing protein
- Raptor N-terminal CASPase-like domain-containing protein
- Ethanolaminephosphotransferase, putative
- Ras-family member, GTP-binding protein, putative
- Small GTPase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006793 (phosphorus metabolic process), GO:0046470 (phosphatidylcholine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0006656 (phosphatidylcholine biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0006646 (phosphatidylethanolamine biosynthetic process), GO:0046337 (phosphatidylethanolamine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: REF/SRPP-like protein At3g05500 (Q9MA63)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MATQTDLAQPKLDMTKEEKERLKYLQFVQAAAVEALLRFALIYAKAKDKSGPLKPGVESVEGAVKTVVGPVYEKYHDVPVEVLKYMDQKVDMSVTELDRRVPPVVKQVSAQAISAAQIAPIVARALASEVRRAGVVETASGMAKSVYSKYEPAAKELYANYEPKAEQCAVSAWKKLNQLPLFPRLAQVAVPTAAFCSEKYNDTVVKAAEKGYRVTSYMPLVPTERISKIFAEEKAETEPLEFHPLD
InterPro domains: - IPR008802: Rubber elongation factor (family) [15-236]
Interaction partners: - Seipin-2
- Voltage-dependent L-type calcium channel subunit
- Seipin-1
- Transmembrane 9 superfamily member 8
- Alpha/beta-Hydrolases superfamily protein
- Oleosin family protein
- Probable membrane-associated kinase regulator 6
- Protein NRT1/ PTR FAMILY 4.2
- 11-beta-hydroxysteroid dehydrogenase 1B
- Metal tolerance protein 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0090693 (plant organ senescence), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:0099402 (plant organ development), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0010150 (leaf senescence), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0048367 (shoot system development), GO:0048827 (phyllome development), GO:0006996 (organelle organization), GO:0034389 (lipid droplet organization), GO:0048366 (leaf development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)
Protein: U9-MYRTX-Tb1a (A0A6M3Z526)
Organism: Tetramorium bicarinatum (Tramp ant)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MKLSFLSLALAIIFVMATIYAPQVKAKASADADADADAAASANALAEASAGIVTKLIKKGVKLGLKMALGKK
InterPro domains: - IPR049518: Ant venom peptides (family) [1-64]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Lysine-specific demethylase (EC 1.14.11.65) (A0A8I6AC36)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369087}.
Sequence: MADAAASPVGKRLLLLFADPTASASASAPTAAAAVSGDPGPALRTRAWRAGTVRAMSGAVPQDLAIFVEFDGCNWKQHAWVKVHAEEVLALLLEGSLVWAPRKDPVLLQGTRVPVAQWPALTFTPLVDKLGLGSVVPVEYLVDRELRFMSDANGLHLFQMGTDVQNQILLEHAALRETVNALVSDQKLQEIFSRGPYSVQGHRVKVYQPEGEEAWLCGVVSRQDSISRLMEVSISETGEIKSVDPRLIHVMLMDNSTPQSESSRSSSLASSGFGVSLSSLSQPLTFGSGRSQSNGVLATENKPLGFSLSRSSASESQKDSDLSKNLFFQCMSQNLPSSNYFTSGSEGVADDSSSRDSFRQSLESLSSGLGKGRPVLGADTKPGPKAGSSVDRKVPAESMPTLTPAFPRSLLNTRTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSSSSATTVTSKATPSWPESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALSTGGPSLSAMGNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSTVFGRHAGSFLSSPAEFAQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKSGLKGPPEHLMGKLGPDGGRSAELLLGKGKGKQAPKGRPRTAPLKVGQSVLKDVSKVRKLKQSGEPFLQDGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLVFTRKGVLRVEGFLSPQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAWKRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWLKCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQSKSVLRPAVTNGISQLPSITPSASSGNETTFSSGGGTVATTNPEPEQAPKGAGADSRAEEPLKAEGSASNSNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKDAGSLRSVLSKESHSPFGLDSLNSTAKGSPLTPKLFNSLLLGPTASNSKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFSSSSAGAKSKASLPNFLDHIIASVVENKKTSDSSKRSCNLTDTQKEVKEMVMGLNVLDPHTSHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGDQDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPTRFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLHLDVSDAVNVMVYVGIPIGEGAHDEEVLRTIDEGDADEVTKQRIHDGKEKPGALWHIYAAKDAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQILRKRLFEEYGVQGWAIVQFLGDAVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNIIYHAVKDAVGTLKAHESKLARS
InterPro domains: - IPR054503: Lysine-specific demethylase 3A/B, tudor domain (domain) [191-259]
- IPR054504: Lysine-specific demethylase 3B, PWWP domain (domain) [91-189]
- IPR045109: Lysine-specific demethylase LSDs-like (family) [306-1556]
- IPR054294: Domain of unknown function DUF7030 (domain) [8-80]
- IPR003347: JmjC domain (domain) [1299-1522]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0072718 (response to cisplatin)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cell adhesion molecule 3 (Zgc:136589) (B0CLV6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MSGMRARQTLAFPSFQRAALRALAAFTMILATSVRSNYVYDDDPFQPVTQDETVAVGGVVTLTCGVKENDNSSLQWSNTAQQTLYFGEKRALRDNRIQLVKSTATELIITIGDVQLSDDGEYTCSIFTMPVRTARATVTVLGVPGKPVITGFEGAVQEGGKVTLTCTSSGSKPPAKLHWYRDHVEIQGRPDVVESNPNEPTYTVTSELTLSVSRDDNDALIACAVDHPSIANGDKRTEQPLNVLFSPRVSIHPESDLPREGEKFYLQCVGNGNPEPNAFVWRRKEGELPPLAKVDGAFLRFESLNKSDNGVYECQADNGIGMGDVAHTLLVQEAGENAADPTAMSTGSGVDHAVIGGVVAVIVFIMLCLLLVLGRYLIRHKGTYLTHEAKGSDDAPDADTAIINAEGGHSGVDDKKEYFI
InterPro domains: - IPR003585: Neurexin/syndecan/glycophorin C (domain) [373-391]
- IPR013106: Immunoglobulin V-set domain (domain) [53-138]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [49-332]
- IPR013162: CD80-like, immunoglobulin C2-set (domain) [159-229]
- IPR007110: Immunoglobulin-like domain (domain) [47-332]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [42-339]
- IPR003598: Immunoglobulin subtype 2 (domain) [55-321]
- IPR003599: Immunoglobulin domain subtype (domain) [49-332]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0003206 (cardiac chamber morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0003205 (cardiac chamber development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007507 (heart development), GO:0003007 (heart morphogenesis), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)
Protein: KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) (Q91WI7)
Organism: Mus musculus (Mouse)
Function: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Subcellular location: Lysosome membrane {ECO:0000250|UniProtKB:Q969R8}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000250|UniProtKB:Q969R8}.
Sequence: MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGKLSVYKNDDSRPWLTCMCQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTPTKALDASGHHETLGEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEELAEGPEHLAGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTGSPPASEEATGDSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIRQGHNPEGGNAGLFALCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHNRTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLKLLEAEPEYHRLLQELRVDPEDLPAVCTLLHQTLYHPDQPLQCTPSSFQDPT
InterPro domains: - IPR031793: Integrin-alpha FG-GAP repeat-containing protein 2 (family) [1-441]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [12-147]
Interaction partners: - KICSTOR complex protein kaptin
- KICSTOR complex protein SZT2
- KICSTOR subunit 2
- GATOR1 complex protein DEPDC5
- GATOR1 complex protein NPRL2
- GATOR2 complex protein WDR59
- GATOR2 complex protein WDR24
- Lysosome-associated membrane glycoprotein 1
- S-adenosylmethionine sensor upstream of mTORC1
- GATOR1 complex protein NPRL3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0008104 (protein localization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Heat shock factor-binding protein 1 (Nasopharyngeal carcinoma-associated antigen 13) (NPC-A-13) (O75506)
Organism: Homo sapiens (Human)
Function: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subcellular location: Nucleus.
Sequence: MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELESENKIPATQKS
InterPro domains: - IPR009643: Heat shock factor binding 1 (family) [3-73]
Interaction partners: - WASH complex subunit 3
- Heat shock factor protein 1
- Heat shock 70 kDa protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Neuropeptide Y receptor type 6 (NPY6-R) (Pancreatic polypeptide receptor 2) (PP2) (Q61212)
Organism: Mus musculus (Mouse)
Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY = PYY >= NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MEVLTNQPTPNKTSGKSNNSAFFYFESCQPPFLAILLLLIAYTVILIMGIFGNLSLIIIIFKKQREAQNVTNILIANLSLSDILVCVMCIPFTVIYTLMDHWVFGNTMCKLTSYVQSVSVSVSIFSLVLIAIERYQLIVNPRGWKPRVAHAYWGIILIWLISLTLSIPLFLSYHLTNEPFHNLSLPTDIYTHQVACVEIWPSKLNQLLFSTSLFMLQYFVPLGFILICYLKIVLCLRKRTRQVDRRKENKSRLNENKRVNVMLISIVVTFGACWLPLNIFNVIFDWYHEMLMSCHHDLVFVVCHLIAMVSTCINPLFYGFLNKNFQKDLMMLIHHCWCGEPQESYENIAMSTMHTDESKGSLKLAHIPTGI
InterPro domains: - IPR000611: Neuropeptide Y receptor family (family) [63-329]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [52-318]
- IPR000986: Neuropeptide Y6 receptor (family) [2-347]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [37-326]
Interaction partners: - Pro-neuropeptide Y
- Peptide YY
- Proto-oncogene tyrosine-protein kinase Src
- Pancreatic polypeptide prohormone
- Tyrosine-protein kinase HCK
- RAC-alpha serine/threonine-protein kinase
- Tyrosine-protein kinase Fyn
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008188 (neuropeptide receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0003008 (system process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0007631 (feeding behavior), GO:0008217 (regulation of blood pressure), GO:0048638 (regulation of developmental growth), GO:0005996 (monosaccharide metabolic process), GO:0050877 (nervous system process), GO:0005975 (carbohydrate metabolic process), GO:0040014 (regulation of multicellular organism growth), GO:0003013 (circulatory system process), GO:0007626 (locomotory behavior), GO:0019318 (hexose metabolic process), GO:0008015 (blood circulation), GO:0007600 (sensory perception), GO:0006006 (glucose metabolic process), GO:0019233 (sensory perception of pain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)