Protein: AP-2 complex subunit alpha (A0A8I5ZVC3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane, coated pit {ECO:0000256|ARBA:ARBA00004277}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004277}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004277}.
Sequence: MRDRPLGSHGRQTAPKPAPALCSSWATGKRRGGRKLITLPLVAGGCLWPCVPCSLSTGKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPERESSILAKLKRKKGPGAASALDDSRRDTSSNDINGGVEPTPSNVSTPSPSADLLGLRAAPPPAAPPAPVGGNLLVDVFSDGPTAQPSLGPTPEEAFLRFVCKNSGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQSFLIHVDHHSVELAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLLSVRFRYGGTAQSLTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPLQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCELLAQQF
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [59-626]
- IPR012295: TBP domain superfamily (homologous_superfamily) [856-968]
- IPR050840: Adaptor Complexes Large Subunit (family) [57-947]
- IPR013041: Clathrin adaptor, appendage, Ig-like subdomain superfamily (homologous_superfamily) [734-854]
- IPR008152: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (domain) [739-849]
- IPR003164: Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (domain) [855-964]
- IPR009028: Coatomer/calthrin adaptor appendage, C-terminal subdomain (homologous_superfamily) [855-968]
- IPR011989: Armadillo-like helical (homologous_superfamily) [54-656]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [65-624]
- IPR017104: Adaptor protein complex AP-2, alpha subunit (family) [54-968]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0005543 (phospholipid binding), GO:0019900 (kinase binding), GO:0035091 (phosphatidylinositol binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0051049 (regulation of transport), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:0030100 (regulation of endocytosis), GO:0048260 (positive regulation of receptor-mediated endocytosis), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0010976 (positive regulation of neuron projection development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0030135 (coated vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0016323 (basolateral plasma membrane), GO:0031982 (vesicle), GO:0030136 (clathrin-coated vesicle), GO:0097708 (intracellular vesicle)