Protein: Protein unc-119 homolog A (Retinal protein 4) (rRG4) (Q62885)
Organism: Rattus norvegicus (Rat)
Function: Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13432}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q13432}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q13432}. Note=ocalizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000250|UniProtKB:Q13432}.
Sequence: MKVKKGGGGTGPGAEPVPGASNRSVEPTREPGAEAESGSESEPEPGPGPRLGPLQGKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKADYSYSGTP
InterPro domains: - IPR014756: Immunoglobulin E-set (homologous_superfamily) [78-236]
- IPR037036: GMP phosphodiesterase, delta subunit superfamily (homologous_superfamily) [52-240]
- IPR051519: PDE6D/unc-119 myristoyl-binding (family) [27-239]
- IPR008015: GMP phosphodiesterase, delta subunit (domain) [80-236]
Interaction partners: - ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 2
- Peptidyl-prolyl cis-trans isomerase E
- ADP-ribosylation factor-like protein 13A
- Sad1 and UNC84 domain containing 1
- Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- SPO11, initiator of meiotic double stranded breaks.
- Nephrocystin-3
- Unc-79 homolog, NALCN channel complex subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051051 (negative regulation of transport), GO:0048523 (negative regulation of cellular process), GO:0032879 (regulation of localization), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0051129 (negative regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0045806 (negative regulation of endocytosis), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0030100 (regulation of endocytosis), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0048261 (negative regulation of receptor-mediated endocytosis), GO:0042953 (lipoprotein transport), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0044872 (lipoprotein localization), GO:2000369 (regulation of clathrin-dependent endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030424 (axon), GO:0005634 (nucleus)