Protein: Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) (Q9BYG5)
Organism: Homo sapiens (Human)
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Subcellular location: Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
Sequence: MNRSHRHGAGSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIKKKNVLTNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIEDNGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEFETHAPDQKLLEEDGTIITL
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [126-253]
- IPR051741: Partitioning defective 6 homolog protein (family) [13-253]
- IPR053793: PB1-like domain (domain) [16-96]
- IPR000270: PB1 domain (domain) [16-96]
- IPR034868: Partitioning defective protein 6, PB1 domain (domain) [17-96]
- IPR001478: PDZ domain (domain) [157-250]
Interaction partners: - Protein kinase C zeta type
- Cell division control protein 42 homolog
- Partitioning defective 3 homolog
- Protein kinase C iota type
- LLGL scribble cell polarity complex component 2
- Partitioning defective 6 homolog gamma
- Protein crumbs homolog 3
- Lethal
- Ras-related C3 botulinum toxin substrate 3
- Protein PALS1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0019058 (viral life cycle), GO:0044403 (biological process involved in symbiotic interaction), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046718 (viral entry into host cell), GO:0046907 (intracellular transport), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0090150 (establishment of protein localization to membrane), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0006612 (protein targeting to membrane), GO:0006605 (protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005911 (cell-cell junction), GO:0043296 (apical junction complex), GO:0070160 (tight junction), GO:0005634 (nucleus), GO:0005923 (bicellular tight junction)