Protein: REST corepressor 3 (Q6PGA0)
Organism: Mus musculus (Mouse)
Function: May act as a component of a corepressor complex that represses transcription.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.
Sequence: MPGMMEKGPELLGKSRSANGGAKSPAGGGGSSANGGLHFSEPESGCSSDDEHGDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEEAHPMDGNDSDYDPKKEAKREGNADQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEAQTPQAPRTLGPSPPAPSSTPTPTVPIATLNQPPPLLRPTLPAAPALHRQPPPLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLTTVGGQQPPSLIGIQTDSQPSLH
InterPro domains: - IPR051066: Transcriptional Regulator and Corepressor (family) [42-343]
- IPR001005: SANT/Myb domain (domain) [141-189]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [130-189]
- IPR000949: ELM2 domain (domain) [55-139]
- IPR049048: REST corepressor, helical domain (domain) [271-335]
- IPR017884: SANT domain (domain) [140-191]
Interaction partners: - Lysine-specific histone demethylase 1A
- High mobility group protein 20A
- Histone deacetylase 2
- Genetic suppressor element 1
- PHD finger protein 21B
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- Histone deacetylase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0003714 (transcription corepressor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032259 (methylation), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0043414 (macromolecule methylation), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006479 (protein methylation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0006325 (chromatin organization), GO:0031060 (regulation of histone methylation), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0008213 (protein alkylation), GO:0031399 (regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0018193 (peptidyl-amino acid modification), GO:0051570 (regulation of histone H3-K9 methylation), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0018022 (peptidyl-lysine methylation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0031401 (positive regulation of protein modification process), GO:0016571 (histone methylation), GO:0016570 (histone modification), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0031058 (positive regulation of histone modification), GO:0034968 (histone lysine methylation), GO:0031507 (heterochromatin formation), GO:0031056 (regulation of histone modification), GO:0006476 (protein deacetylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0070828 (heterochromatin organization), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018205 (peptidyl-lysine modification), GO:1901983 (regulation of protein acetylation), GO:0018023 (peptidyl-lysine trimethylation), GO:0080182 (histone H3-K4 trimethylation), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0051568 (histone H3-K4 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)