Protein: Roundabout homolog 4 isoform X1 (F1RE66)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MQVSAWMLWVAWLCTCSKAVRQCACPPDEQVAQRSEGKGHLRHRLMHQRASHRDRAHRRKGSRLVSEINLPRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTELKGKLIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFFCEADGDPMPSIEWSREQGPLPNGRYLINPDHSLQIHYVTAQDMGRYSCTVENKLGVSVASAQLLVEDAGGTRLRDLHKELSALRVSLENVTVMSTASNMSQVMWKLQSFGSQPHYLEGFEVLYRSLLPASSDWTAQRVPQPSLHTHVGPLKRGYKYEFKVRPYGSSLYGRESNTRHLRVPEIVPSAAPQDVSITMPAERNDTVHLSWEPPPHDAHNGIIQGYQVWCVESEEQTSFNWTVDSGTHSIEIFTLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIESRLEATPYQTGILSMSHFVSVIKEPVFIGSVGTLLWCVLMITAVFLYRRHIRPANPSGKSSGLYRLESEDLIIKHRMAAPDSPWISGGWRPGSNSEPKQGLWTPSQENSGLRRTTLPITVKKDPNPLRSAVPIVPDNCGVYGTFYVDLTGNGLKTFNSPGRCPRMPHGNSQLQNSETIRITEPIVKTAVVRELQALPWKRTLPAQPNMGVKKESWEKNVKRELHAVKSAPLMPLNQQALAVCSAPNHQQRFSQHPAGGVSEPVKPLSSPRILHYSASLQLVDMLPSPPPLPMEDNHSLSSEDESTRSTKLTVDIGSQQSVCAASGLQGPASANTGCPNNHSPAQLSPSYSHLSTASFCLSTDDYQDTTLSTQGHTQYMEISPKPQGQSTSHQSTPSMPRPFSPTPTLGYICGPGDREMDEEQETVPIGLRRATLRSTPSSCCSEWEGSLWNGWGSVSESNVTSARTSIISSSDCSFINDANFARVLALTAESMSGNLSDFSPPASPLSVLFPPRECFGEVEPLPVWDWSTAWVEELEAQFKASRDPRRPARNSGIERWRGHLESPSHR
InterPro domains: - IPR013098: Immunoglobulin I-set (domain) [175-350]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [71-351]
- IPR007110: Immunoglobulin-like domain (domain) [71-351]
- IPR003598: Immunoglobulin subtype 2 (domain) [83-340]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [374-562]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [69-591]
- IPR003961: Fibronectin type III (domain) [369-570]
- IPR003599: Immunoglobulin domain subtype (domain) [77-351]
Interaction partners: - Slit homolog 3 (Drosophila)
- Netrin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009967 (positive regulation of signal transduction), GO:0035239 (tube morphogenesis), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:0001568 (blood vessel development), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0090132 (epithelium migration), GO:0030155 (regulation of cell adhesion), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0045785 (positive regulation of cell adhesion), GO:0016477 (cell migration), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0010631 (epithelial cell migration), GO:0030030 (cell projection organization), GO:0048514 (blood vessel morphogenesis), GO:0010810 (regulation of cell-substrate adhesion), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0030334 (regulation of cell migration), GO:1902531 (regulation of intracellular signal transduction), GO:0001667 (ameboidal-type cell migration), GO:0022607 (cellular component assembly), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0001954 (positive regulation of cell-matrix adhesion), GO:0030031 (cell projection assembly), GO:0001952 (regulation of cell-matrix adhesion), GO:0120036 (plasma membrane bounded cell projection organization), GO:0043542 (endothelial cell migration), GO:0051057 (positive regulation of small GTPase mediated signal transduction), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0097581 (lamellipodium organization), GO:0046578 (regulation of Ras protein signal transduction), GO:0046579 (positive regulation of Ras protein signal transduction), GO:0035020 (regulation of Rac protein signal transduction), GO:0030032 (lamellipodium assembly), GO:0035022 (positive regulation of Rac protein signal transduction), GO:0046847 (filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)