Protein: Probable polyketide synthase 5 (Q86JI5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Probable polyketide synthase
Sequence: MDMKLNDIENENFINQMKGVAIVGIGFRIPSGNSENSISSPDDLFNNLKNGFDGVSSTSERWSDNYHKLGEISSPNAGLLPLNEWKSFDPLFFGINPSDAHHIDPQQRLLLKCTWEALEDASIDPISIRGTNTSVFIGSSTIDYLHANKHPDLILKNAIGFSPSTLSNRISYCFDIHGPSLSIDTACSSSMNAVTQGYHSILNGTSNMSIVGGVNFVIDVETIKGFSYLNMLSKTHGKCKAFDESGDGFTRGECAGVVVLKKLDDAIRDGNRIYCIINGISSNIDGNGIADKANFYSPSKQSQFNNINLAFKSTNGKISVNDIQYIEAHGTGTKTGDPIETEAISMAFKNRDKSTPILIGSIKSNIGHCEAGSGVVSLIKCCLMFKYQCFLPNIHFKNPNPLIKFNEWNLKVVTSPIPFNRNNEKSVSMMINNFGVTGSNCCLLISEFKKQDYESYENNIGSINKNILVPFSANSPKSLDQYQSKIKNIINNQFNFIDFANNQIYSKSNYLYQRSVVIANNSNDLVNKILNKKHIQTKNPIISNMSFKGKNPITIFVFSGQGSQYPKMALELYNNEVIFKKSIDLIDSKLSKYYGYSVLEKLRSIGDDDTTSIHDPTIAQPAMCMFSVSLFELYKHWGVNPSFILGHSLGEIPTSYCSGMIDLDTFCYTVYQRSIAQTKTHGNGRMLSINISDEEFKSMYSQKYPQIEIACYNSPQSIVVAGNESILNEISKELKEKEIFTAMLGSLSSFHTSSQQCTKDSILQLNIESKKSKVPTFSTVTTNLFNESDPFNSQYVYDNIINPVKFTQTISNIYKHIESNQLDNDIVFIEIAPHPTLSFYIKQMVPSSLNESVSVYSALHKKKNDVEEFQQTISNLYCQNGYNINFKCQFNNKKSNQKINLPLYQWDDELYFAQTQVLEQHRKEGPPIDHLGLSNSYYSPFKNSYRTFIDIKNKPFQYLKGHMVKGKYYFPGCGYIDNIIQLYKNQDIFISFIEFKTPLILIEGINQCLQTNIQQTGKSEYRAQFHFKDQKSNEWIQSSNANFQLLDHTIEMPPKYNIEEIIKNKCTLARLTKNEIYTHIKSKTGLNYTAMFQGATECYIGVDCTLSVVSIESQTNSFLNIPILDSVFHGNISLINDQCQIVFDKVHGLKYYSSNIPNDYKDKSVYVYAKLKSKTSDSYSASFTVLLSDGTVVYEIDEAFSKSLIPIKELLKIEYPNDELFSINLQPKDSPIPAPSTFKSLIYENDRFNAEPPMVENLFQYISTIFYKNIINRCPEINIDIIKSLSIDEIISNFSKISKHERLFKYVFETIKENGILNSLEEKDDTYFVFNEVLIKSSRVISKLLFPLENDNDNEDTPQLLFQNGLMDKVYKCRYLKNKNQMIAHIIKHSIKEIINNNIIIRILEFGGGTASLSVEVIEEIVTLLQENPNYQVEIEYTWSDISPAFIVDTKNKINKIIKGAGITNGLNVIYHPLTIDESLVELQSIKPSYYDFVIMSNVLHVVKDIKQAVEQMYQLLIPNGQLLFVEPPYKSIICDSLFGSFEQWWAFTDTDIRKDHCCLSQDGWYKLLKWSNFESIEMSTESKFMGSVIQAQKPSFTSLINQQPKYDNIIIFGNNCPNFIDNIKPFSNFNEFIQIETIQEFDQLINKSTITNDSIIYFIKSINQLSLDNYKQATLEYIEINQKLLQINSLCKHVLIVNDSRKTNYLASSIVGAARYFDEFQQLKLHTLDFDYDSTQNYLISKNNKMVQFINNLIDSKTNVHKEMIIINNKVYYEIVQKEKNLKLKYNSESFEQQDNLMCSLSPNLEYQLQSKQIKLRDNQVEVKTIATGINNKDYLVYSGLEGSVNSNTPQFGYEFSGIITRVGNNVKDYKVGDNVFGLSNSCTSSNIIVNHERIQIKPSNISHIEAASIPIDYLTSFMSLFNVGCLNIEDNESILIHLGSDSFGLSTFEILKWKGFKSNLFVTVNSDEIKQYLLNNYGDLITAIYSNTDKGYVSQIKNKLIEQGSNDNGVDLILNTLPSDFMDSNFQLLAINGRIIDLSNDHLNQSEYMKNVNFTLNRGYHNFDLMSQRNSRINRSLLTISKAIENGELKLIPIKEFSNSDINDAIEFIIEENRIDKIVVSHDHEVYQELYAKFSNENDFSILKSNYQINSNNLGKNILITGQSGIILEILKWIIKYSNINTIENVIILSRSSLKWELELLINQTKLSNNNIKFHFKSVDVGDSEQVDNAINEILNENQEIINIHSIFHFAFTQIACKVQEINMKHLDISHGAKTMGAINLHNQSIKRNWKLINFVISSSIASLVGSTDQCSYVCANALLDSFSKYRVSLGLPSTSINLGAIESTGFVSKNESISVFLDGSGIIPTPINQVLGLLDLQIQNPGKFTNSMVAKFNPLNFSNNEQINLLLKMDYIFNLHSNGYTKVKESAGSKNVDELFIKKISDLFSIDESKINKDIRLIDYGADSLVIVQLKNWVDQEIGFNLITIQQLQNNTINVSIKIILNFLKKINK
InterPro domains: - IPR013217: Methyltransferase type 12 (domain) [1404-1523]
- IPR020843: Enoylreductase domain (domain) [1801-2122]
- IPR014043: Acyl transferase domain (domain) [555-872]
- IPR036736: ACP-like superfamily (homologous_superfamily) [2437-2501]
- IPR016035: Acyl transferase/acyl hydrolase/lysophospholipase (homologous_superfamily) [555-854]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1902-2353]
- IPR001227: Acyl transferase domain superfamily (homologous_superfamily) [555-866]
- IPR020841: Polyketide synthase, beta-ketoacyl synthase domain (domain) [17-450]
- IPR016039: Thiolase-like (homologous_superfamily) [11-469]
- IPR011032: GroES-like superfamily (homologous_superfamily) [1814-1940]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [1819-1884]
- IPR018201: Beta-ketoacyl synthase, active site (active_site) [178-194]
- IPR042104: Polyketide synthase, dehydratase domain superfamily (homologous_superfamily) [952-1204]
- IPR032821: Polyketide synthase, C-terminal extension (domain) [399-517]
- IPR014031: Beta-ketoacyl synthase, C-terminal (domain) [274-396]
- IPR016036: Malonyl-CoA ACP transacylase, ACP-binding (homologous_superfamily) [682-744]
- IPR009081: Phosphopantetheine binding ACP domain (domain) [2427-2511]
- IPR014030: Beta-ketoacyl synthase-like, N-terminal (domain) [18-266]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [1283-1594]
- IPR013968: Polyketide synthase-like, ketoreductase domain (domain) [2161-2345]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0099120 (socially cooperative development), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0099135 (chimeric colonial development), GO:0031156 (regulation of sorocarp development), GO:0030587 (sorocarp development), GO:1901261 (regulation of sorocarp spore cell differentiation), GO:0099136 (chimeric non-reproductive fruiting body development), GO:0099134 (chimeric sorocarp development), GO:0099139 (cheating during chimeric sorocarp development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)