Protein: Integrin alpha-PS2 (Position-specific antigen subunit alpha-2) (Protein inflated) [Cleaved into: Integrin alpha-PS2 heavy chain; Integrin alpha-PS2 light chain] (P12080)
Organism: Drosophila melanogaster (Fruit fly)
Function: Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Lateral cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Basal cell membrane {ECO:0000269|PubMed:19035354}; Single-pass type I membrane protein {ECO:0000269|PubMed:19035354}. Note=During mid-oogenesis, localizes to the apical, to the lateral and to the basal membranes of follicle cells. Apical membrane localization peaks at oogenesis stages 9 and 10A in columnar follicle cells overlying the oocyte while decreases in the most posterior follicle cells. During embryogenesis, at the end of germband extension concentrates at the basal membrane of mesodermal cells, where they adhere to the ectoderm. Then, in visceral mesoderm localizes basally, whereas in somatic mesoderm is homogenously distributed.
Sequence: MSGDSIHRRRMALHCPITSLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRYQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACAPRYVFHTMTPSRAFRIDPVGTCFTSHNFEEFYEVSPCRTNNWGYHRQGSCQAGFSAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSESASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNRWNMANIFNITGRQIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIRDGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQLVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLDDRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLDAKKLLNPRMFFLRDEGKNIRNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNLRSSRPLDPMVRHRRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDLKLKVSTVDKYLFGSPEPLVIEVFISNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHFKISLVPEEKYGSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLYKADDYKELENATKEDDIGPQVVHIYEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPETGGKIQCDDVAFNEYNLLLDEKLVKKSYLQAQGAIWNSAQVSGQSSSSSSSGGASVHIEKARGEGFVRGVLVSNSTDAGDKLSPKQVEQRRQEDTLEALGDASFVHRDRASQAVQEPQVNQTSFTTYSTSSSSSGSGAPSAQLRGHSTQGHIQMAGPVQHTSSSSSSNYRSWPAQQQQQHQQLLLAGSGGSGLGSPVTFNDKSQFGGRNNNFHTGTLDLGTLNRGNVDNELYRSQGQYQNPSQSLGQSQGQFQANANQGHYQGQNQAQFQARNPGFQGQTSYQGQTQYSGQPGGYQTHHVTYSSGSKPYYGRENEDFYDEDNLQQATPGHWSSSSSSSSSSGTRRLRRSNDKDGATEKPLQIDLNSPCQSARCKSIRCVVTNLGTEDGDAAFVAIRARMVAKTMEKLASNVPLNVSTLAVANVTLLPFIGAPKDAIVKTHEIFYKAEPEPLQVPDVVPLWVVVLAACAGALIFLLLVWLLYKCGFFNRNRPTDHSQERQPLRNGYHGDEHL
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [661-798]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1366-1381]
- IPR000413: Integrin alpha chain (family) [276-622]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [499-660]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [32-503]
- IPR013517: FG-GAP repeat (repeat) [332-436]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [501-1347]
- IPR013519: Integrin alpha beta-propellor (repeat) [36-514]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [810-947]
Interaction partners: - Integrin beta-PS
- Integrin alpha-PS1
- Integrin beta-nu
- Integrin alpha-PS3
- Integrin alpha-PS4
- Integrin alpha-PS5
- Teneurin-m
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0001745 (compound eye morphogenesis), GO:0048749 (compound eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0030055 (cell-substrate junction), GO:0005925 (focal adhesion)