Protein: HotDog ACOT-type domain-containing protein (Q580L6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MLRRCFTPSHLIPFLCGGCLSSRRQLVVGNSKNGTKPVASVDWTDLVGKELWSENRLAAGELLAMMDLCAKRVSEVYLSSMKPRVSCSTVGVSTTTFYSPVLHGDVVRMHGRLIYCGSSSMGIHIRFYRRSPSTITESLTGESYFTMVAIDENLRAVKTVPAVELTDENDVSYHNGYLAARNIAAEAKKISSDLQKKSITCSDVECTVNAAKPIRVPIASTRTSAHRIFLLYHLNNNRTIFGGELMRWMERHAVHCGRMFTGNRHISTVAMHNVEFHHPVFGTDWVTLEADIIYVHNTTMEVDVKLVVERDGHVVTTNRASFVLINLNEIGQKTIIPKGLDLSAATEEELLRFAEAKERYRRSRNSRR
InterPro domains: - IPR029069: HotDog domain superfamily (homologous_superfamily) [58-364]
- IPR040170: Cytosolic acyl coenzyme A thioester hydrolase (family) [43-366]
- IPR033120: Hotdog acyl-CoA thioesterase (ACOT)-type domain (domain) [36-330]
- IPR006683: Thioesterase domain (domain) [60-311]
Interaction partners: - Succinyl-CoA:3-ketoacid-coenzyme A transferase
- Acetyl-coenzyme A synthetase
- Enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative
- 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016790 (thiolester hydrolase activity), GO:0016289 (CoA hydrolase activity), GO:0047617 (acyl-CoA hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006631 (fatty acid metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0001676 (long-chain fatty acid metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)