Protein: BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) (M0R0I0)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQ
InterPro domains: - IPR026126: BRISC and BRCA1-A complex member 1 (family) [12-225]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [93-196]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009314 (response to radiation), GO:0046483 (heterocycle metabolic process), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0051726 (regulation of cell cycle), GO:2001022 (positive regulation of response to DNA damage stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045786 (negative regulation of cell cycle), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0006508 (proteolysis), GO:0051052 (regulation of DNA metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:0051054 (positive regulation of DNA metabolic process), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0045739 (positive regulation of DNA repair), GO:2001020 (regulation of response to DNA damage stimulus), GO:0036211 (protein modification process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006259 (DNA metabolic process), GO:0010212 (response to ionizing radiation), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0006282 (regulation of DNA repair), GO:0070647 (protein modification by small protein conjugation or removal), GO:0006281 (DNA repair), GO:0044818 (mitotic G2/M transition checkpoint), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0070646 (protein modification by small protein removal), GO:0000077 (DNA damage checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0007095 (mitotic G2 DNA damage checkpoint signaling), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle), GO:0016579 (protein deubiquitination), GO:0006302 (double-strand break repair), GO:0070536 (protein K63-linked deubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)