Protein: Roundabout homolog 3 isoform X3 (A0A2R8QRK0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MLRYLIKTLLQMNLFTDTIRDATNGTDLFFNISSIPSFNSSLLDWANFTGLNGSRPRLEDAAPRIVEHPSDLIVSKGEPATLNCKAEGRPTPMVEWYKDGERVETDREDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGVYVCVARNYLGEAVSRNASLEVAILRDDFRQTPSDVVVAAGEPAVMECIPPRGHPEPTISWKRNNVKVNDKDERITIRGGKLMISNTRKSDAGMYVCVGTNMVGEKDSDPAELVVFERPMFVRRPVNQVVLADDTVDFQCEVQGDPAPTIRWKKEEGELPRGRFEIRADNSLRLTQVKAEDEGSYTCLSENSVGKAEASGSLQVHVPPQIVVRPRDQISAQGRTVTFLCGTKGNPPPAVFWQKEGSQVLLFPSQPPSQSGRFSVSLSGELTITDVHSEDSGYYICQAISVAGSILTKALLEVESTPSDRIPPIIRQGPANQTLAPGTTAQLQCHVMGNPLPSIQWERDGQRILGIDERISLMENGTLQITALQETDSGAYTCVASSLSGETSWSGVLTVKESGGLSASPVSEPYQLPGPPQKPVVTDVTRNSVTLTWQPNAHEGGAAVTSYIIEAFSQSAGSTWQTVADFVKLEKHTVTGLSPNTIYLFIVRAVNAYGLSDPSPISEPVRTQDVSPTGQGVDHRQVQRELGEMSVQLHEPVLLTASSVKISWNVDRQSQYIQGYRLLYRPVGGSWSQQEVKGATERSAVIANLLKGTEYEIKIRPYFNEFQGLDSRSQTLRTPEEVPSAPPRAVNVATVKLSNSSSISVSWQPPPTDMQNGVIQEYKVWCLGNDSQTRYNINQTVDGSVLSTVLKGLLPGVLYQVEVAAVTSAGVGKHSQPVSVLIKLPAEQPTVTGGGSESEENVSLAEQITDVVKQPAFIAGIGGACWVILMGFSVWIYCRRKKRKELSHYTASFAYTPAVGFPHGESSGLNGRPGMLGANMGNYPWLADSWPTTNLVHNGKDSVNCCTSKHETPERYYNEAGISNYLNQNEKYSADSNEGPIYSTIDPTSEDLRSFTAQYSQHTTPYASTPIMPFTNQAPCSPEQDGSHWMTQPGTSNAQYAQPDRSKTENVKQPKQKLMGKPVKTPSLNWMDALPPPPISGDLEQCDEEDDNELIQDMGSDEEEWCPPLPERSYLMDGMVEDGPVPPPRGEASSPTTSYSHQSTATLTPSPRDDGHFHDIPRLHQLEQPHMTRRLPCGPVPVPRAPSPPLTQSNPNLSANQECPDNTVPHRSAHKRDLSQGAAQSVENISNTTPGRARPSADHTSSGQKSKVKKKASKSAQYRRDILQGDLPPPPEPPPEDQDNCAHVGGFECGQTSLERAGSSNSSMERREQSTPNRKNSAHRRIDADDDLIPYNKPNFLSRGQMSSNCSTTGSSSSRGSTGSRGQGTGRKRNDEMR
InterPro domains: - IPR013098: Immunoglobulin I-set (domain) [63-342]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [62-539]
- IPR007110: Immunoglobulin-like domain (domain) [63-536]
- IPR003598: Immunoglobulin subtype 2 (domain) [75-527]
- IPR032986: Roundabout homologue 1, immunoglobulin-like domain 3 (domain) [260-342]
- IPR051170: Neural and epithelial cell adhesion domain-containing protein (family) [106-447]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [553-863]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [57-898]
- IPR013106: Immunoglobulin V-set domain (domain) [273-522]
- IPR003961: Fibronectin type III (domain) [555-867]
- IPR003599: Immunoglobulin domain subtype (domain) [69-538]
Interaction partners: - Protein kinase C-binding protein NELL2a
- NEL-like protein 2
- Netrin-1
- Netrin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0016049 (cell growth), GO:0008037 (cell recognition), GO:0032989 (cellular component morphogenesis), GO:0008038 (neuron recognition), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009799 (specification of symmetry), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0003002 (regionalization), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0030030 (cell projection organization), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0016198 (axon choice point recognition), GO:0048666 (neuron development), GO:0009855 (determination of bilateral symmetry), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0009953 (dorsal/ventral pattern formation), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048262 (determination of dorsal/ventral asymmetry), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048264 (determination of ventral identity), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0016199 (axon midline choice point recognition), GO:0048699 (generation of neurons), GO:0048675 (axon extension), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0071679 (commissural neuron axon guidance), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0030424 (axon)