Protein: Multidrug resistance-like ATP-binding protein MdlB (P0AAG5)
Organism: Escherichia coli (strain K12)
Subcellular location: Cell inner membrane; Multi-pass membrane protein
Sequence: MRSFSQLWPTLKRLLAYGSPWRKPLGIAVLMMWVAAAAEVSGPLLISYFIDNMVAKNNLPLKVVAGLAAAYVGLQLFAAGLHYAQSLLFNRAAVGVVQQLRTDVMDAALRQPLSEFDTQPVGQVISRVTNDTEVIRDLYVTVVATVLRSAALVGAMLVAMFSLDWRMALVAIMIFPVVLVVMVIYQRYSTPIVRRVRAYLADINDGFNEIINGMSVIQQFRQQARFGERMGEASRSHYMARMQTLRLDGFLLRPLLSLFSSLILCGLLMLFGFSASGTIEVGVLYAFISYLGRLNEPLIELTTQQAMLQQAVVAGERVFELMDGPRQQYGNDDRPLQSGTIEVDNVSFAYRDDNLVLKNINLSVPSRNFVALVGHTGSGKSTLASLLMGYYPLTEGEIRLDGRPLSSLSHSALRQGVAMVQQDPVVLADTFLANVTLGRDISEERVWQALETVQLAELARSMSDGIYTPLGEQGNNLSVGQKQLLALARVLVETPQILILDEATASIDSGTEQAIQHALAAVREHTTLVVIAHRLSTIVDADTILVLHRGQAVEQGTHQQLLAAQGRYWQMYQLQLAGEELAASVREEESLSA
InterPro domains: - IPR011527: ABC transporter type 1, transmembrane domain (domain) [26-310]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [335-579]
- IPR003593: AAA+ ATPase domain (domain) [366-557]
- IPR039421: Type 1 protein exporter (family) [9-577]
- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [6-325]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [477-491]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [341-574]
Interaction partners: - Multidrug resistance-like ATP-binding protein MdlA
- Spermidine/putrescine import ATP-binding protein PotA
- Probable iron export ATP-binding protein FetA
- Thiamine import ATP-binding protein ThiQ
- Putrescine transport ATP-binding protein PotG
- L-cystine transport system ATP-binding protein TcyN
- Glutamine transport ATP-binding protein GlnQ
- Glutamate/aspartate import ATP-binding protein GltL
- Glutamate/aspartate import ATP-binding protein GltL
- DNA-binding transcriptional activator DecR
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015562 (efflux transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0140352 (export from cell), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0006810 (transport), GO:0044249 (cellular biosynthetic process), GO:0140115 (export across plasma membrane), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0006766 (vitamin metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0009110 (vitamin biosynthetic process), GO:0044272 (sulfur compound biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006768 (biotin metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0042364 (water-soluble vitamin biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0009102 (biotin biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)