Protein: Acetylornithine/succinyldiaminopimelate aminotransferase (P18335)
Organism: Escherichia coli (strain K12)
Function: Involved in both the arginine and lysine biosynthetic pathways
Subcellular location: Cytoplasm
Sequence: MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
InterPro domains: - IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [20-401]
- IPR004636: Acetylornithine/Succinylornithine transaminase family (family) [16-403]
- IPR050103: Class-III Pyridoxal-phosphate-dependent Aminotransferase (family) [13-403]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [30-393]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [60-305]
- IPR005814: Aminotransferase class-III (family) [21-402]
- IPR049704: Aminotransferases class-III pyridoxal-phosphate attachment site (conserved_site) [223-260]
- IPR017652: Acetyl/Succinylornithine transaminase family, bacteria (family) [8-404]
Interaction partners: - N-acetyl-gamma-glutamyl-phosphate reductase
- Acetylglutamate kinase
- Amino-acid acetyltransferase
- Argininosuccinate lyase
- Acetylornithine deacetylase
- 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
- Succinyl-diaminopimelate desuccinylase
- Succinyl-diaminopimelate desuccinylase
- Argininosuccinate synthase
- Ornithine carbamoyltransferase subunit I
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043168 (anion binding), GO:0019842 (vitamin binding), GO:0016769 (transferase activity, transferring nitrogenous groups), GO:0070279 (vitamin B6 binding), GO:0008483 (transaminase activity), GO:0030170 (pyridoxal phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0006520 (amino acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0009063 (amino acid catabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009065 (glutamine family amino acid catabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0006591 (ornithine metabolic process), GO:0006527 (arginine catabolic process), GO:0006525 (arginine metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006105 (succinate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)