Protein: Histone-lysine N-methyltransferase, H3 lysine-37 specific (EC 2.1.1.-) (Q9Y7Q6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Histone lysine methyltransferase that specifically mono-, di-, and trimethylates 'Lys-37' of histone H3 to regulate sporulation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:30773398}. Nucleus {ECO:0000269|PubMed:30773398}.
Sequence: MRIPVIRSPLEIRDTERKGRGVFALEPIPAQTCIEISPVLMFSKEEYEQHGQYTVLNEYTYVWSEGKQGLALGLGSMFNHDRHPNVYWKKDNRNNYISYYTLREIKTNEELCISYGDHLWFEDEASSASRISPNEENEDFPLQNISL
InterPro domains: - IPR009207: Histone-lysine N-methyltransferase, H3 lysine-37 specific (family) [1-140]
- IPR046341: SET domain superfamily (homologous_superfamily) [6-127]
- IPR001214: SET domain (domain) [8-122]
Interaction partners: - tRNA-specific adenosine deaminase subunit tad2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0051302 (regulation of cell division), GO:0051726 (regulation of cell cycle), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0090068 (positive regulation of cell cycle process), GO:0104004 (cellular response to environmental stimulus), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0080134 (regulation of response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0045786 (negative regulation of cell cycle), GO:0051782 (negative regulation of cell division), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0044087 (regulation of cellular component biogenesis), GO:0045787 (positive regulation of cell cycle), GO:0071456 (cellular response to hypoxia), GO:0007346 (regulation of mitotic cell cycle), GO:1901891 (regulation of cell septum assembly), GO:1901989 (positive regulation of cell cycle phase transition), GO:0071453 (cellular response to oxygen levels), GO:0062197 (cellular response to chemical stress), GO:1901987 (regulation of cell cycle phase transition), GO:0071470 (cellular response to osmotic stress), GO:0032954 (regulation of cytokinetic process), GO:0032465 (regulation of cytokinesis), GO:1902532 (negative regulation of intracellular signal transduction), GO:0045931 (positive regulation of mitotic cell cycle), GO:1902531 (regulation of intracellular signal transduction), GO:0060491 (regulation of cell projection assembly), GO:0032006 (regulation of TOR signaling), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0032955 (regulation of division septum assembly), GO:1902751 (positive regulation of cell cycle G2/M phase transition), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0046578 (regulation of Ras protein signal transduction), GO:0010971 (positive regulation of G2/M transition of mitotic cell cycle), GO:0046580 (negative regulation of Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)