wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (BGnT-7) (Beta-1,3-Gn-T7) (Beta-1,3-N-acetylglucosaminyltransferase 7) (Beta3Gn-T7) (EC 2.4.1.-) (Q8K0J2)
Organism: Mus musculus (Mouse)
Function: N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (By similarity). Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency. May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion.
Subcellular location: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MSLWKKTLYKSVCLALALLVAVTVFQRSVTPGQFLQDPLPPTPGPAKTGNLVNPNSFWKSSKDVAAPTPTVPRGPQVWDVITTNCSININLTHQPWFQSLEPHFRQFLAYRHCRYFPMLLNHPEKCAGDVYMLVVVKSVITQHDRREVIRQTWGHEWESAGLGRGAVRTLFLLGTASKQEERTHYQQLLAYEDRLYADILQWDFLDSFFNLTLKEIHFLKWLDIYCPNVPFVFKGDDDVFVNPTNLLEFLSDRQPQENLFVGDVLKHARPIRKKDNKYYIPAVMYGKATYPPYAGGGGFLMSGSLARQLHHACDTLELFPIDDVFLGMCLEVLGVKPTGHEGFKTFGISRVRSSRMNKEPCFYRAMLVVHKLLPAELLAMWDLVHSNLTCSVKFQVL
InterPro domains: - IPR002659: Glycosyl transferase, family 31 (family) [103-348]
Interaction partners: - Keratocan
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0035250 (UDP-galactosyltransferase activity), GO:0008378 (galactosyltransferase activity), GO:0008375 (acetylglucosaminyltransferase activity), GO:0048531 (beta-1,3-galactosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009311 (oligosaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0009312 (oligosaccharide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V) (P57058)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [65-321]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [182-194]
- IPR034671: Hormonally up-regulated neu tumour-associated kinase, catalytic domain (domain) [58-320]
- IPR017441: Protein kinase, ATP binding site (binding_site) [68-100]
- IPR000719: Protein kinase domain (domain) [62-320]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Elongation factor family protein (F4K409)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MELSLSTSSASPAVLRRQASPLLHKQQVLGVSFASALKPGGGALRFPSRRPLPRPITCSASPSTAEPASVEVKKKQLDRRDNVRNIAIVAHVDHGKTTLVDSMLRQAKVFRDNQVMQERIMDSNDLERERGITILSKNTSITYKNTKVNIIDTPGHSDFGGEVERVLNMVDGVLLVVDSVEGPMPQTRFVLKKALEFGHAVVVVVNKIDRPSARPEFVVNSTFELFIELNATDEQCDFQAIYASGIKGKAGLSPDDLAEDLGPLFEAIIRCVPGPNIEKDGALQMLATNIEYDEHKGRIAIGRLHAGVLRKGMDVRVCTSEDSCRFARVSELFVYEKFYRVPTDSVEAGDICAVCGIDNIQIGETIADKVHGKPLPTIKVEEPTVKMSFSVNTSPFSGREGKYVTSRNLRDRLNRELERNLAMKVEDGETADTFIVSGRGTLHITILIENMRREGYEFMVGPPKVINKRVNDKLLEPYEIATVEVPEAHMGPVVELLGKRRGQMFDMQGVGSEGTTFLRYKIPTRGLLGLRNAILTASRGTAILNTVFDSYGPWAGDISTRDLGSLVAFEDGTSTSYALASAQERGQMFVGSGVDVYKGQIVGIHQRPGDLGLNICKKKAATNIRSNKDVTVILDTPLTYSLDDCIEYIEEDELVEVTPSSIRMCKNQKMAKKGRQ
InterPro domains: - IPR047043: GTP-binding protein BipA, domain 3 (domain) [383-461]
- IPR031157: Tr-type G domain, conserved site (conserved_site) [122-137]
- IPR047042: GTP-binding protein BipA, domain 2 (domain) [283-376]
- IPR004161: Translation elongation factor EFTu-like, domain 2 (domain) [297-367]
- IPR042116: GTP-binding protein TypA/BipA, C-terminal (homologous_superfamily) [561-668]
- IPR006298: GTP-binding protein BipA (family) [83-675]
- IPR035647: EF-G domain III/V-like (homologous_superfamily) [381-590]
- IPR000795: Translational (tr)-type GTP-binding domain (domain) [81-276]
- IPR005225: Small GTP-binding domain (domain) [84-233]
- IPR048876: TypA/BipA, C-terminal domain (domain) [564-668]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [72-283]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [229-376]
- IPR047041: GTP-binding protein BipA, GTP-binding domain (domain) [82-275]
- IPR000640: Elongation factor EFG, domain V-like (domain) [473-562]
- IPR035651: BipA, domain V (domain) [476-555]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006996 (organelle organization), GO:0009657 (plastid organization), GO:0009658 (chloroplast organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ribulose bisphosphate carboxylase small subunit, chloroplastic (NbRbCS) (RuBisCO small subunit) (A0A0S4IJL0)
Organism: Nicotiana benthamiana
Function: RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site. Although the small subunit is not catalytic it is essential for maximal activity (By similarity). Involved in antiviral defenses.
Subcellular location: Plastid, chloroplast {ECO:0000250|UniProtKB:P69249, ECO:0000255|HAMAP-Rule:MF_00860}.; SUBCELLULAR LOCATION: Cell junction, plasmodesma {ECO:0000269|PubMed:23148080}. Note=(Microbial infection) May be present in virus replication complexes (VRCs) of tobamovirus infected cells. {ECO:0000269|PubMed:23148080}.
Sequence: MASSVLSSAAVATRSNVAQANMVAPFTGLKSAASFPVSRKQNLDITSIASNGGRVQCMQVWPPINKKKYETLSYLPDLSVEQLLSEIEYLLKNGWVPCLEFETEHGFVYREHHKSPGYYDGRYWTMWKLPMFGCTDATQVLAEVEEAKKAYPQAWIRIIGFDNVRQVQCISFIAYKPEGY
InterPro domains: - IPR024680: Ribulose-1,5-bisphosphate carboxylase small subunit, N-terminal (domain) [2-44]
- IPR024681: Ribulose bisphosphate carboxylase, small subunit (family) [1-179]
- IPR000894: Ribulose bisphosphate carboxylase small subunit, domain (domain) [67-178]
- IPR036385: Ribulose bisphosphate carboxylase, small subunit superfamily (homologous_superfamily) [58-180]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0015979 (photosynthesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0031967 (organelle envelope), GO:0048046 (apoplast), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0043228 (non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009941 (chloroplast envelope), GO:0009579 (thylakoid)
Protein: Cyclin-B2-3 (G2/mitotic-specific cyclin-B2-3) (CycB2;3) (Q9LDM4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MVRSDENSLGLIGSMSLQGGGVVGKIKTTATTGPTRRALSTINKNITEAPSYPYAVNKRSVSERDGICNKPPVHRPVTRKFAAQLADHKPHIRDEETKKPDSVSSEEPETIIIDVDESDKEGGDSNEPMFVQHTEAMLEEIEQMEKEIEMEDADKEEEPVIDIDACDKNNPLAAVEYIHDMHTFYKNFEKLSCVPPNYMDNQQDLNERMRGILIDWLIEVHYKFELMEETLYLTINVIDRFLAVHQIVRKKLQLVGVTALLLACKYEEVSVPVVDDLILISDKAYSRREVLDMEKLMANTLQFNFSLPTPYVFMKRFLKAAQSDKKLEILSFFMIELCLVEYEMLEYLPSKLAASAIYTAQCTLKGFEEWSKTCEFHTGYNEKQLLACARKMVAFHHKAGTGKLTGVHRKYNTSKFCHAARTEPAGFLI
InterPro domains: - IPR048258: Cyclins, cyclin-box (conserved_site) [210-241]
- IPR004367: Cyclin, C-terminal domain (domain) [308-425]
- IPR013763: Cyclin-like domain (domain) [215-394]
- IPR039361: Cyclin (family) [144-411]
- IPR006671: Cyclin, N-terminal (domain) [180-305]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [169-425]
- IPR046965: Cyclin A/B-like (family) [14-429]
Interaction partners: - Cyclin-dependent kinase B1-2
- Cell division cycle 20.4, cofactor of APC complex
- Cyclin-dependent kinase B1-1
- Cyclin-dependent kinase B2-1
- Cyclin-dependent kinases regulatory subunit 1
- Cell division cycle 20.3, cofactor of APC complex
- Wee1-like protein kinase
- Cell division cycle 20.5, cofactor of APC complex
- Cyclin-dependent kinase B2-2
- Cell division cycle 20.2, cofactor of APC complex
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051338 (regulation of transferase activity), GO:1904029 (regulation of cyclin-dependent protein kinase activity), GO:0051246 (regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:0043549 (regulation of kinase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein nipi-4 (No induction of peptide after drechmeria infection protein 4) (O16262)
Organism: Caenorhabditis elegans
Function: Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment.
Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Sequence: MELDHTPPPSVLNDNCSASYMTPYATVIAMSGLYLLAIFYFCKKSKKMCQPMSDSIYPYQKRLTQLERELKNYLIDEESIEVDDFQIGQTADGFIFRGGVFPKTRNRFNAKVTTAVKISFPIVSKSISLLEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPGGTLADYFQFKVREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTEPDLRKCEVKLGDFGDAPMGLEYSTPIIAYMPPEILCCAERIPPHRPENDVWMFGVFIWECLTLGAQPHFRKSVEEIKKSFRLPDRGLSCPPTCPLDVWTLVSDCLSEPHMRPRFASTTNASITSRLSELHHIVSPALFLYAIPNQSVCTCIEHHCQSVIHY
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [111-367]
- IPR050122: Receptor Tyrosine Kinase (family) [26-351]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [86-351]
- IPR000719: Protein kinase domain (domain) [81-368]
Interaction partners: - E3 ubiquitin-protein ligase CBL
- Sex muscle abnormal protein 5
- SHC-transforming protein homolog 1
- Tensin homolog
- non-specific serine/threonine protein kinase
- Tyrosine-protein phosphatase non-receptor type ptp-2
- Cell death abnormality protein 2
- Sodium-dependent transporter snf-12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0003002 (regionalization), GO:0009799 (specification of symmetry), GO:0009855 (determination of bilateral symmetry), GO:0060972 (left/right pattern formation), GO:0007368 (determination of left/right symmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Biglycan (Bone/cartilage proteoglycan I) (Leucine-rich PG I) (PG-S1) (P21809)
Organism: Bos taurus (Bovine)
Function: May be involved in collagen fiber assembly.
Subcellular location: Secreted, extracellular space, extracellular matrix.
Sequence: MWPLWPLAALLALSQALPFEQKAFWDFTLDDGLPMLNDEEASGAETTSGIPDLDSLPPTYSAMCPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLLQVVYLHTNNITKVGVNDFCPVGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYKK
InterPro domains: - IPR050333: Small Leucine-Rich Proteoglycans (family) [48-365]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [62-369]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [63-95]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [94-323]
- IPR001611: Leucine-rich repeat (repeat) [94-301]
- IPR016352: Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan (family) [1-369]
Interaction partners: - Decorin
- Toll-like receptor 2
- Fibromodulin
- Aggrecan core protein
- Collagen alpha-1
- Elastin
- Collagen alpha-2
- Transforming growth factor beta-1 proprotein
- Syndecan-1
- Toll-like receptor 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001501 (skeletal system development), GO:0060348 (bone development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0005886 (plasma membrane), GO:0042383 (sarcolemma), GO:0062023 (collagen-containing extracellular matrix)
Protein: Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (Q59LL5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MSREALINRITNETKIQIALNLDGGKLELKESIFPNQSIIIDEHHAKQVSGSQYINVQTGIGFLDHMIHALAKHSGWSLIVECIGDLHIDDHHTAEDVGISLGMAFKQALGQIKGVKRFGHGFAPLDEALSRAVVDLSNRPFAVIELGLKREKIGDLSTEMIPHVLESFAGAAGITIHVDCLRGFNDHHRAESAFKALAIAIKEAISKTGKNDIPSTKGVLS
InterPro domains: - IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [3-206]
- IPR038494: Imidazole glycerol phosphate dehydratase domain superfamily (homologous_superfamily) [1-222]
- IPR020565: Imidazoleglycerol-phosphate dehydratase, conserved site (conserved_site) [89-196]
- IPR000807: Imidazoleglycerol-phosphate dehydratase (family) [2-222]
Interaction partners: - Imidazole glycerol phosphate synthase hisHF
- Histidine biosynthesis trifunctional protein
- histidinol-phosphate transaminase
- ATP phosphoribosyltransferase
- 1-
- N-
- 3-isopropylmalate dehydrogenase
- Orotidine 5'-phosphate decarboxylase
- Phosphoribosylaminoimidazole carboxylase
- phosphoserine phosphatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006547 (histidine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0000105 (histidine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Opacity protein opA68 (opA27.5) (Q04881)
Organism: Neisseria gonorrhoeae
Function: Implicated in a number of adherence functions. OPA proteins are implicated in pathogenesis and are subject to phase variation.
Subcellular location: Cell outer membrane.
Sequence: AGEGNGRGPYVQADLAYAYEHITHDYPKPTDPSKGKLSTVSDYFRNIRTHSIHPRVSVGYDFGGWRIAADYARYRKWNDSKYSVSIKNLQRRTSNGNRRDRKTENQENGSFHAVSSLGLSAVYDFKLNDKFKPYIGARVAYGHVRHSIDSTKKITQFLTTAGARGTVSTVHPPYKSTQDAHHQSDSIRRVGLGVIAGVGFGITPKLTLDAGYRYHNWGRLENTRFKTHEASLGVRYRF
InterPro domains: - IPR011250: Outer membrane protein/outer membrane enzyme PagP, beta-barrel (homologous_superfamily) [8-238]
- IPR003394: Porin, opacity type (domain) [58-238]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009279 (cell outer membrane), GO:0019867 (outer membrane), GO:0030313 (cell envelope)