Protein: Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) (Q76EQ0)
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Sequence: MCAQYCISFADVEKAHLNIQDSVHLTPVLTSSILNQIAGRNLFFKCELFQKTGSFKIRGALNAIRGLIPDTLEGKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPNCKKLAIQAYGASIVYSEPSDESRENVAQRIIQETEGILVHPNQEPAVIAGQGTIALEVLNQVPLVDALVVPVGGGGMVAGIAITIKTLKPSVKVYAAEPSNADDCYQSKLKGELTPNLHPPETIADGVKSSIGLNTWPIIRDLVDDVFTVTEDEIKYATQLVWERMKLLIEPTAGVGLAAVLSQHFQTVSPEVKNICIVLSGGNVDLTSLSWVKQAERPAP
InterPro domains: - IPR001926: Tryptophan synthase beta chain-like, PALP domain (domain) [21-314]
- IPR000634: Serine/threonine dehydratase, pyridoxal-phosphate-binding site (binding_site) [47-60]
- IPR036052: Tryptophan synthase beta chain-like, PALP domain superfamily (homologous_superfamily) [8-324]
Interaction partners: - Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase
- Cystathionine beta-synthase
- Phosphoserine phosphatase
- Serine dehydratase-like
- Alanine--glyoxylate aminotransferase
- D-amino-acid oxidase
- PRKCA-binding protein
- Disrupted in schizophrenia 1 homolog
- serine C-palmitoyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0019842 (vitamin binding), GO:0043177 (organic acid binding), GO:0043168 (anion binding), GO:0016840 (carbon-nitrogen lyase activity), GO:0070279 (vitamin B6 binding), GO:0016832 (aldehyde-lyase activity), GO:0031406 (carboxylic acid binding), GO:0016841 (ammonia-lyase activity), GO:0030170 (pyridoxal phosphate binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0043207 (response to external biotic stimulus), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0009617 (response to bacterium), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006520 (amino acid metabolic process), GO:0010033 (response to organic substance), GO:1901566 (organonitrogen compound biosynthetic process), GO:0032496 (response to lipopolysaccharide), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0033993 (response to lipid), GO:0002237 (response to molecule of bacterial origin), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009069 (serine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0046416 (D-amino acid metabolic process), GO:0009070 (serine family amino acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006563 (L-serine metabolic process), GO:0006090 (pyruvate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)