Protein: ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1) (Protein hennin) (Q640N2)
Organism: Mus musculus (Mouse)
Function: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex.
Subcellular location: Cell projection, cilium membrane {ECO:0000269|PubMed:17488627, ECO:0000269|PubMed:20231383, ECO:0000269|PubMed:21976698, ECO:0000269|PubMed:23153492, ECO:0000269|PubMed:23817546, ECO:0000269|PubMed:24120134, ECO:0000269|PubMed:24339792, ECO:0000269|PubMed:26582389}; Lipid-anchor {ECO:0000269|PubMed:17488627, ECO:0000269|PubMed:20231383, ECO:0000269|PubMed:21976698, ECO:0000269|PubMed:23153492, ECO:0000269|PubMed:23817546, ECO:0000269|PubMed:24120134, ECO:0000269|PubMed:24339792}. Cell projection, cilium {ECO:0000269|PubMed:25138100}. Note=Associates with the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.
Sequence: MFSLMANCCNLFKRWREPVRKVTLVMVGLDNAGKTATAKGIQGEHPEDVAPTVGFSKIDLRQGKFQVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDEERMEETKETMSEVLRHPRISGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAVLGYGKKIDKSIKKGLYWLLHIIAKDFDALSERIQKDTTEQRALEEQEKRERAERVRKLREEREREQTELDGTSGLAEIDSGPVLANPFQPIAAVIIENEKKQEKEKKKQTVEKDSDVGLLEHKVEPEQAAPQSEADCCLQNPDERVVDSYREALSQQLDSEDEQDQRGSESGENSKKKTKKLRMKRSHRVEPVNTDESTPKSPTPPQPPPPVGWGTPKVTRLPKLEPLGETRHNDFYGKPLPPLAVRQRPNGDAQDTIS
InterPro domains: - IPR006689: Small GTPase superfamily, ARF/SAR type (family) [2-190]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [19-226]
- IPR005225: Small GTP-binding domain (domain) [22-141]
- IPR051995: Ciliary function-associated GTPase (family) [1-398]
Interaction partners: - Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
- Phosphatidylinositol polyphosphate 5-phosphatase type IV
- Intraflagellar transport protein 88 homolog
- Pericentrin
- Centrosomal protein of 164 kDa
- Kinesin-like protein KIF3A
- Meckelin
- Jouberin
- Centrosomal protein of 290 kDa
- G-protein coupled receptor 161
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0071310 (cellular response to organic substance), GO:0034097 (response to cytokine), GO:1990823 (response to leukemia inhibitory factor), GO:0071345 (cellular response to cytokine stimulus), GO:1990830 (cellular response to leukemia inhibitory factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)