Protein: AP-3 complex subunit delta-1 (B7ZUU8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T- cell and NK cell degranulation. In concert with the BLOC-1 complex, AP- 3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
Sequence: MALKIVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISTCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDVSWAAFNIVEVMSSSKFTYKRIGYLAASQCFHEGTDVIMLTTNQIRKDLSSPNQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLIMYKVFLKYPESLRPAFPRLKEKLEDPDPGVQSAAVNVICELARRNPKNYLSLAPLFFKLMTSSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMLHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIASQMLDVAIRVKAIRAFAVAQMATLLDNAHLLTGNTQRNGICEVLYAAAWICGEFAEHLEDPMLTLEAMLRPKVATLPGHIQAVYVQNAAKLFATVLQKHEGETDSQAAQETSQLLIDRLPLFVQSANLEVQERASCILQLVKYIQKLQQKNVEVAEEVTALFAGELNPVAPKAQKKVPIPEGLDLDAWINEPPSESESEDEKPKAVFAKEEPKHSRSRHTEVDEKELARRREARKQEQANNPFYIKASPSSQKVYDAPGVEHIPVVQIDLSVPLKVPGMPMSDQYVKLEEERRQKEKADKKKKEKKKKREKRGKGRKGDSGPESEEDITPAHHVDIVTEEMPENALPSDDDDKDPNDPHKALDIDLDKPLADSEKLPVRTHRPEVLKSPAEDRDDNTIPQETKKKSSKDKKEKKKDKEKDRKRSKEDKKKKKKHKDVEEELPESLPEEVVQSEETKEVAVPPTSADASDLDFWLSSAPVPPVAQVVTVSSSAAAATVDSSSAAAAESEPEELKDTEPDDTKSSKHKKKKQKKEKEEKEKKKKKRHHHHHHHHSDAGAEDSVQNGTVEDEEPLPPMSNYSLLAENSYIKMVCDIQGNHQDESKVVVSVIFENKSDSFLKSMEFNVLDSLNSKLQRPDGAGPHDGLTVPFQLPPGVSNEARFVFSVQSIVMPQKLKGTLTFIVKTDESSTHEKLDFKLHFTCTSYLITTPCYSDAYAKLLESGDLKGSSLRLEGVNMPFHHLLARICFHHHFSVVERIDSCASMYSRSIQGHHVCLLVKSSDQTVSIDAKCDEPSLLGNVLDEIKQTFSKC
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [29-641]
- IPR011989: Armadillo-like helical (homologous_superfamily) [6-594]
- IPR058898: AP-3 complex subunit delta, Mu C-terminal domain (domain) [1140-1244]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [32-580]
- IPR010474: AP-3 complex subunit delta domain, metazoa (domain) [660-805]
- IPR017105: Adaptor protein complex AP-3, delta subunit (family) [2-995]
Interaction partners: - AP-3 complex subunit sigma-2
- AP-3 complex subunit mu-1 isoform X1
- Arpin
- AP complex subunit sigma
- AP-2 complex subunit mu-B
- AP complex subunit beta
- AP complex subunit beta
- DDB1- and CUL4-associated factor 5
- Nucleolar transcription factor 1 isoform X1
- Malignant T-cell-amplified sequence 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043474 (pigment metabolic process involved in pigmentation), GO:0033059 (cellular pigmentation), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0021700 (developmental maturation), GO:0048066 (developmental pigmentation), GO:0043476 (pigment accumulation), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0021675 (nerve development), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0043324 (pigment metabolic process involved in developmental pigmentation), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0051648 (vesicle localization), GO:0043170 (macromolecule metabolic process), GO:0071695 (anatomical structure maturation), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0046907 (intracellular transport), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0048469 (cell maturation), GO:0030900 (forebrain development), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0050931 (pigment cell differentiation), GO:0080090 (regulation of primary metabolic process), GO:0048069 (eye pigmentation), GO:0009416 (response to light stimulus), GO:0051905 (establishment of pigment granule localization), GO:0030030 (cell projection organization), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0032990 (cell part morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0007369 (gastrulation), GO:0048666 (neuron development), GO:0007420 (brain development), GO:0061387 (regulation of extent of cell growth), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0021761 (limbic system development), GO:0051247 (positive regulation of protein metabolic process), GO:0007417 (central nervous system development), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0032400 (melanosome localization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043009 (chordate embryonic development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048048 (embryonic eye morphogenesis), GO:0031399 (regulation of protein modification process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0006897 (endocytosis), GO:0021954 (central nervous system neuron development), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0007041 (lysosomal transport), GO:0031401 (positive regulation of protein modification process), GO:0048812 (neuron projection morphogenesis), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0061564 (axon development), GO:0031290 (retinal ganglion cell axon guidance), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0007409 (axonogenesis), GO:0031396 (regulation of protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005802 (trans-Golgi network), GO:0097708 (intracellular vesicle)