Protein: Melanocortin receptor 5 (A3KGQ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MNTSETTLPFWGMHVNSSPASYILNATETPSHNKPKACEQLNIATEVFLILGIVSLLENILVICAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETIVIYLLTNRQLVVEDHFIRQMDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAALIIGGIWTFCTGCGIVFIIYSDNTSVIVCLVSMFFIMLALMASLYSHMFMLARSHVKRIAALPGYNSIHQRASMKAAVTLTILLGIFIVCWAPFFLHLILMISCPRNLYCMCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTLKEIICCYSLRNVFGMSR
InterPro domains: - IPR000621: Melanocortin 5 receptor (family) [28-327]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [58-300]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [43-315]
- IPR001671: Melanocortin/ACTH receptor (family) [68-317]
- IPR001908: Melanocortin receptor 3-5 (family) [185-316]
Interaction partners: - Pro-opiomelanocortin protein
- Proopiomelanocortin b
- Melanocortin-2 receptor accessory protein 2B
- Melanocortin-2 receptor accessory protein 2A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050795 (regulation of behavior), GO:0097009 (energy homeostasis), GO:0048521 (negative regulation of behavior), GO:0006091 (generation of precursor metabolites and energy), GO:0007186 (G protein-coupled receptor signaling pathway), GO:2000252 (negative regulation of feeding behavior), GO:0060259 (regulation of feeding behavior), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0006112 (energy reserve metabolic process), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)