Protein: RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (Raf-1) (A0A0S2Z559)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Sequence: MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [364-631]
- IPR046349: C1-like domain superfamily (homologous_superfamily) [130-184]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [56-131]
- IPR020454: Diacylglycerol/phorbol-ester binding (domain) [136-185]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [484-496]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [138-185]
- IPR017441: Protein kinase, ATP binding site (binding_site) [375-395]
- IPR003116: Raf-like Ras-binding (domain) [56-131]
- IPR000719: Protein kinase domain (domain) [369-629]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [266-629]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0012501 (programmed cell death), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009611 (response to wounding), GO:0044092 (negative regulation of molecular function), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0043086 (negative regulation of catalytic activity), GO:0043254 (regulation of protein-containing complex assembly), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0031279 (regulation of cyclase activity), GO:0006796 (phosphate-containing compound metabolic process), GO:0036211 (protein modification process), GO:0031333 (negative regulation of protein-containing complex assembly), GO:0042060 (wound healing), GO:0043412 (macromolecule modification), GO:0051339 (regulation of lyase activity), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0045761 (regulation of adenylate cyclase activity), GO:0042981 (regulation of apoptotic process), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0031399 (regulation of protein modification process), GO:0052547 (regulation of peptidase activity), GO:0045937 (positive regulation of phosphate metabolic process), GO:0031281 (positive regulation of cyclase activity), GO:0043066 (negative regulation of apoptotic process), GO:0006468 (protein phosphorylation), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0043410 (positive regulation of MAPK cascade), GO:0045861 (negative regulation of proteolysis), GO:0051349 (positive regulation of lyase activity), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0046578 (regulation of Ras protein signal transduction), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0045762 (positive regulation of adenylate cyclase activity), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0033138 (positive regulation of peptidyl-serine phosphorylation), GO:0033135 (regulation of peptidyl-serine phosphorylation), GO:0035023 (regulation of Rho protein signal transduction), GO:0010951 (negative regulation of endopeptidase activity), GO:0007190 (activation of adenylate cyclase activity), GO:2000117 (negative regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0005794 (Golgi apparatus), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031968 (organelle outer membrane), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)