Protein: Synaptonemal complex central element protein 1 (Q9D495)
Organism: Mus musculus (Mouse)
Function: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination.
Subcellular location: Nucleus {ECO:0000269|PubMed:15944401}. Chromosome {ECO:0000269|PubMed:15944401, ECO:0000269|PubMed:16968740}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. {ECO:0000269|PubMed:15944401}.
Sequence: MATRPQPLGMEPEGSADLLHGPEGARGQYGSTQKIEDLMDMVKKLQKVGSLEPRIEVLINRINEVQQAKKKASEELGEAQTVWDNLQKELDLLREEKVRLKDILNRKEETLRIMQLHCQEKESEAQRKHSMLQECKERISFLNSQIDKEKAKLRKLRLDFEEHLETLMSQHKDTLEFHKPEHLTKEMCVLDSSKEQLLKEEKLMKVKLEDVRQRLCALGGPEGSSSLIEGLFLRSHEAAAAMQMFKDENKKAEEFLEAAAQQHEQLQQRCHQLQQKRQRLKEELEKHGVQILAHSTQNEEDSSWRMASPKPVEVHEETAQDQERPSSRT
InterPro domains: - IPR026676: Synaptonemal complex central element protein 1 (family) [1-319]
Interaction partners: - Synaptonemal complex central element protein 2
- Testis-expressed protein 12
- Synaptonemal complex protein 1
- Synaptonemal complex central element protein 3
- Synaptonemal complex protein 3
- Cohesin subunit SA-3
- HORMA domain-containing protein 1
- Meiotic recombination protein REC8 homolog
- Protein SIX6OS1
- Structural maintenance of chromosomes protein 1B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0061982 (meiosis I cell cycle process), GO:0016043 (cellular component organization), GO:0045132 (meiotic chromosome segregation), GO:0007059 (chromosome segregation), GO:0044085 (cellular component biogenesis), GO:0140013 (meiotic nuclear division), GO:0045143 (homologous chromosome segregation), GO:0022607 (cellular component assembly), GO:0007130 (synaptonemal complex assembly), GO:0098813 (nuclear chromosome segregation), GO:0007129 (homologous chromosome pairing at meiosis), GO:0006996 (organelle organization), GO:0007127 (meiosis I), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0000280 (nuclear division), GO:0070193 (synaptonemal complex organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0099086 (synaptonemal structure), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0000795 (synaptonemal complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)