Protein: Guanine nucleotide-binding protein subunit alpha (Q59FM5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor {ECO:0000256|ARBA:ARBA00004193}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: LESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
InterPro domains: - IPR011025: G protein alpha subunit, helical insertion (homologous_superfamily) [65-184]
- IPR001019: Guanine nucleotide binding protein (G-protein), alpha subunit (family) [8-357]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [36-351]
- IPR000654: G-protein alpha subunit, group Q (family) [7-320]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097367 (carbohydrate derivative binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:1902494 (catalytic complex), GO:0019898 (extrinsic component of membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0005576 (extracellular region), GO:0098797 (plasma membrane protein complex), GO:0019897 (extrinsic component of plasma membrane), GO:1905360 (GTPase complex), GO:0098562 (cytoplasmic side of membrane), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0009898 (cytoplasmic side of plasma membrane), GO:0065010 (extracellular membrane-bounded organelle), GO:0005834 (heterotrimeric G-protein complex), GO:0031982 (vesicle), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane), GO:1903561 (extracellular vesicle)