Protein: L-dopachrome tautomerase (A1L1Y0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)
Subcellular location: Melanosome membrane; Single-pass type I membrane protein
Sequence: MKRFVLMLCCFGCMYLSEAQFPRVCCTVEGIVSKECCPALGSDPANVCGLLAGRGNCSDVHVDSKPWGGPYSLRNVDDRERWPTKFFNRTCRCFGNFAGYNCGECKFGWTGLNCDQRKAPVLRKDIHSLSPEELQEFLNALDLSKTTVHPDYMIASQHWLGLLGPNGTEPQFSNISIYDFFVWQHYYSVRDTLLGPGRPFKAIDFSHKGPAFITWHRYHLLSLERELQKLTGNENFAVPYWNFATGQSECDVCTDSLLGGRDPSDPSRISPRSRFARWGVVCDSLDEYNRLVTLCNGTNEGSLRRGAAMSTNVTLPTMNDVRSCLNLRDFDSPPYFTNSTFSFRNALEGYDKPDGELDTSVSNLHNLVHQFLNGTSALSHSAANDPIFLVLHAFTDAIFDEWMRRFRENETFPDEMAPIGHNRHYNMVPFFPPVTNEEIYIASEQLGYSYSIDLEELDNRPAMFLLGSTLGGIFLGLLLLLIVLVLYIQQRRKREFEPLLNAEFTNTKYSGEA
InterPro domains: - IPR050316: Tyrosinase and Hemocyanin (family) [34-453]
- IPR002227: Tyrosinase copper-binding domain (domain) [177-404]
- IPR008922: Di-copper centre-containing domain superfamily (homologous_superfamily) [78-464]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0016863 (intramolecular oxidoreductase activity, transposing C=C bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0033059 (cellular pigmentation), GO:0071840 (cellular component organization or biogenesis), GO:0048066 (developmental pigmentation), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0050931 (pigment cell differentiation), GO:0016043 (cellular component organization), GO:0048753 (pigment granule organization), GO:0060041 (retina development in camera-type eye), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0097066 (response to thyroid hormone), GO:0048880 (sensory system development), GO:0003406 (retinal pigment epithelium development), GO:0007423 (sensory organ development), GO:0032438 (melanosome organization), GO:0030318 (melanocyte differentiation), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0001654 (eye development), GO:0016050 (vesicle organization), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0048770 (pigment granule), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0042470 (melanosome), GO:0097708 (intracellular vesicle)