Protein: Armadillo repeat-containing protein wrm-1 (Worm armadillo protein 1) (Q10953)
Organism: Caenorhabditis elegans
Function: Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Component of the beta-catenin-lit-1 complex which promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Within the complex, activates lit-1-dependent kinase activity. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning and can activation transcription in yeast. Involved in the development of distal tip cells (DTC) by regulating the asymmetric distribution of cye-1 and cki-1 between the daughters of Z1.a and Z4.p cells.
Subcellular location: Cytoplasm, cell cortex {ECO:0000269|PubMed:16077003, ECO:0000269|PubMed:17276345, ECO:0000269|PubMed:25569233}. Nucleus {ECO:0000269|PubMed:16077003, ECO:0000269|PubMed:17276345}. Note=Located in the anterior cell cortex before and during asymmetric cell division. After division, located preferentially in the nucleus of the posterior daughter cell. {ECO:0000269|PubMed:16077003, ECO:0000269|PubMed:17276345, ECO:0000269|PubMed:25569233}.
Sequence: MDVDCAETFSQPCTPLNFNPMTPSTSRVSTPVRPSSTMSARQYSGSPFKAQPQNMEPSNSRVQELREAAVGKRSYTNAWMQGTYAPPQMAGQQQRFSRPPSVIGSTMSHMTNMSEMTAYSYGGLSMLSVNTEMGEFNNFVNQAPYQRALTRVSQVSENQDPTNRQYPMTAPEIIENLESTELINQAAAIRALEPIVKAGGMLQTWGPKGAEPIIRALFQVLIPRPVENENVIRKAFEILHHSILLSNKEIRRIDRMFFRLNAALMDPNGPPVFNVPKPYSIYEIVMTRAIQLDTKFESSAMVLLVHLCCKPHFMKIFFGEDETQQSPAHRRLHKIVIEFAIGNLRRPETKSKNKGLCVSIIKNLSNKNATIKDMSERLGVVSLFHQIMQNEVIHEDLLWSTMQALTVFCGDVKNGTHFVQMGGAQVLCGLLSHGSTRLLHELLKCLRRVSDLPAIQEQDMKESIHCIVQLIGCSDVTIVELATGTLRNIGLHNKMNKAFMVQDGVTSHAIAVLRTSEQFTYQPHANIDLYRKQILSIYENCLSVLNNVTSMAPQDIKESAVSACRMISENADSAYVLLHYFNVGNRKCRKLAVTVMKRVIETVPAFADPFVDLLGTTNEPLPILLLQRAFQSLDEWRKTSVEMMNCDGRSAEQRRELDDRRKDHEDIVKRSVGLLTNLCSQANPRFFHSLKLVLTNGTLNPFQWLTHEMSDGILQEWLAFILSICSRDESLQTFMMYRFLEQAKMTEAFFAELKARRQNSNIQTMLSKIIDLGRHQQRIVSQQHQQHQMQHHRQLM
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [354-736]
- IPR013284: Beta-catenin (family) [2-792]
- IPR011989: Armadillo-like helical (homologous_superfamily) [141-792]
- IPR000225: Armadillo (repeat) [411-550]
Interaction partners: - Protein pop-1
- Serine/threonine kinase NLK
- Casein kinase I isoform alpha
- Beta-catenin-like protein hmp-2
- Axin-like protein pry-1
- Adenomatous polyposis coli protein-related protein 1
- Glycogen synthase kinase-3
- Beta-catenin homolog sys-1
- F-box/WD repeat-containing protein lin-23
- Beta-catenin/armadillo-related protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007163 (establishment or maintenance of cell polarity), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0022402 (cell cycle process), GO:0032879 (regulation of localization), GO:0007389 (pattern specification process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0019098 (reproductive behavior), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0008219 (cell death), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0030029 (actin filament-based process), GO:0007017 (microtubule-based process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0007610 (behavior), GO:0012501 (programmed cell death), GO:1903047 (mitotic cell cycle process), GO:0030010 (establishment of cell polarity), GO:2000145 (regulation of cell motility), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0018991 (oviposition), GO:0001708 (cell fate specification), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0000226 (microtubule cytoskeleton organization), GO:0051782 (negative regulation of cell division), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0010453 (regulation of cell fate commitment), GO:0045165 (cell fate commitment), GO:0040028 (regulation of vulval development), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0051653 (spindle localization), GO:0051656 (establishment of organelle localization), GO:0009889 (regulation of biosynthetic process), GO:0010623 (programmed cell death involved in cell development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009798 (axis specification), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0002164 (larval development), GO:0080090 (regulation of primary metabolic process), GO:0000278 (mitotic cell cycle), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0016055 (Wnt signaling pathway), GO:0010172 (embryonic body morphogenesis), GO:0007369 (gastrulation), GO:0051294 (establishment of spindle orientation), GO:0030334 (regulation of cell migration), GO:0070986 (left/right axis specification), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0042659 (regulation of cell fate specification), GO:0060972 (left/right pattern formation), GO:0051293 (establishment of spindle localization), GO:0031326 (regulation of cellular biosynthetic process), GO:0048569 (post-embryonic animal organ development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0030335 (positive regulation of cell migration), GO:0051252 (regulation of RNA metabolic process), GO:0007498 (mesoderm development), GO:0002119 (nematode larval development), GO:0006996 (organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0040001 (establishment of mitotic spindle localization), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0007010 (cytoskeleton organization), GO:0060070 (canonical Wnt signaling pathway), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0000132 (establishment of mitotic spindle orientation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0000242 (pericentriolar material), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000776 (kinetochore), GO:0005813 (centrosome), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000793 (condensed chromosome), GO:0015630 (microtubule cytoskeleton)