Protein: Chromatin modification-related protein YNG2 (ESA1-associated factor 4) (ING1 homolog 2) (P38806)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.
Subcellular location: Nucleus {ECO:0000269|PubMed:10805724, ECO:0000269|PubMed:11544250, ECO:0000269|PubMed:14562095}.
Sequence: MDPSLVLEQTIQDVSNLPSEFRYLLEEIGSNDLKLIEEKKKYEQKESQIHKFIRQQGSIPKHPQEDGLDKEIKESLLKCQSLQREKCVLANTALFLIARHLNKLEKNIALLEEDGVLAPVEEDGDMDSAAEASRESSVVSNSSVKKRRAASSSGSVPPTLKKKKTSRTSKLQNEIDVSSREKSVTPVSPSIEKKIARTKEFKNSRNGKGQNGSPENEEEDKTLYCFCQRVSFGEMVACDGPNCKYEWFHYDCVNLKEPPKGTWYCPECKIEMEKNKLKRKRN
InterPro domains: - IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [210-272]
- IPR001965: Zinc finger, PHD-type (domain) [224-269]
- IPR024610: Inhibitor of growth protein, N-terminal histone-binding (domain) [6-111]
- IPR019787: Zinc finger, PHD-finger (domain) [222-271]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [222-271]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [225-268]
- IPR028651: ING family (family) [2-273]
Interaction partners: - Actin-related protein 4
- Enhancer of polycomb-like protein 1
- Chromatin modification-related protein EAF1
- SAGA complex/NuA4 acetyltransferase complex subunit TRA1
- Chromatin modification-related protein EAF3
- SWR1-complex protein 4
- Histone acetyltransferase ESA1
- Chromatin modification-related protein EAF6
- Protein AF-9 homolog
- Chromatin modification-related protein EAF5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0061733 (peptide-lysine-N-acetyltransferase activity), GO:0140030 (modification-dependent protein binding), GO:0016746 (acyltransferase activity), GO:0004402 (histone acetyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0035064 (methylated histone binding), GO:0140034 (methylation-dependent protein binding), GO:0016407 (acetyltransferase activity), GO:0016410 (N-acyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:0036211 (protein modification process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0006259 (DNA metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043543 (protein acylation), GO:0018193 (peptidyl-amino acid modification), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0016570 (histone modification), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0016573 (histone acetylation), GO:0006473 (protein acetylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018205 (peptidyl-lysine modification), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0018394 (peptidyl-lysine acetylation), GO:0006475 (internal protein amino acid acetylation), GO:0018393 (internal peptidyl-lysine acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:0031248 (protein acetyltransferase complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0000123 (histone acetyltransferase complex), GO:0043228 (non-membrane-bounded organelle), GO:1902493 (acetyltransferase complex), GO:1902562 (H4 histone acetyltransferase complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0043189 (H4/H2A histone acetyltransferase complex), GO:0035267 (NuA4 histone acetyltransferase complex)