Protein: Nucleoredoxin (EC 1.8.1.8) (Q6DKJ4)
Organism: Homo sapiens (Human)
Function: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97346}. Nucleus {ECO:0000250|UniProtKB:P97346}.
Sequence: MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [12-433]
- IPR013766: Thioredoxin domain (domain) [167-321]
- IPR041861: Nucleoredoxin, redox inactive TRX-like domain b' (domain) [312-427]
- IPR045870: TryX and NRX, thioredoxin domain (domain) [176-307]
- IPR012336: Thioredoxin-like fold (domain) [33-287]
Interaction partners: - Segment polarity protein dishevelled homolog DVL-1
- Neuroligin-1
- Band 4.1-like protein 5
- Thioredoxin
- Neurexin-1
- Contactin-associated protein 1
- Leucine-rich repeat transmembrane neuronal protein 2
- Neurexin-2
- Segment polarity protein dishevelled homolog DVL-2
- Protein crumbs homolog 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004791 (thioredoxin-disulfide reductase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0047134 (protein-disulfide reductase (NAD(P)) activity), GO:0015036 (disulfide oxidoreductase activity), GO:0016668 (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0045786 (negative regulation of cell cycle), GO:0051129 (negative regulation of cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0044087 (regulation of cellular component biogenesis), GO:0010639 (negative regulation of organelle organization), GO:0033043 (regulation of organelle organization), GO:0046599 (regulation of centriole replication), GO:0046606 (negative regulation of centrosome cycle), GO:0046605 (regulation of centrosome cycle), GO:1902115 (regulation of organelle assembly), GO:0010824 (regulation of centrosome duplication), GO:0010826 (negative regulation of centrosome duplication), GO:0051493 (regulation of cytoskeleton organization), GO:1902116 (negative regulation of organelle assembly), GO:0051494 (negative regulation of cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)