wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Epithelial cell-transforming 2 (A0A8M2B2N3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MADSSILTLGPGRSILVDSSVYDSRMAETSKEQYFIGLHSDETEGVLPRVETRVVLVGEACKMAELEKALQAITIMEVPVVKIKEGQPGTEAREKLIKSIVNMDLNTPCIKTDNVCDFGDGENCEFETVFVLKDFQAPEYSFLYKNDSRILGPPAVMHCANKGEPLPFSSRPLYSMTMLNLSLCFTGFRKKDEVVALVNLVHHMGGTIRKDFDSAKVTHLIARSTHGEKYRLAVCMGTPILTPDWIRKAWEHRDDINFHAGNELFRTEFKVPPFQDCVLSFLGFSEEEKNNMEERTQKHGGRFQAVGDERCTHLVVEENSIKELPFTPSKRLYVVKQEWFWGSIQMDARAGESMYSYEKPESPAMKKAVSLLSLTTPNSGRKRRRLRETLAQLTKETEISPFPPRKRPSAEHSLSMGSLLDISNTPDTKSSGERRCRRSSGRRRSSRQSRSERLQRTSTPVCRHEDQTENAKIPKSSTPALPKQSARWQVSKELYQTESNYVDILATVLQLFKYPLEKEGQVGGPILAQEEIKTIFGSIPDIYEVHTRIKADLEELVMNWSEERSVGDIILKYSGELVKAYPPFVNFFEMSKETIVRCERQKPRFHAFLKINQSKPECGRQTLVELLIRPVQRLPSVALLLNDIKKHTSDDNPDKLTLEKAIESLKEVMTHINEDKRKTEGQKQIFDVVYEVDGCPANLLSSHRSLVHRVETIALGDKPCDRGEHVTLFLFNDCLEIARKRHKVITNFRSPLGQTRPPAQLKHITLMPLSQIRRVLDIQDTEECQNAFALVVRPPTEQENLLFSFQLTAEDTLKTTWLRTLCRQVANTICRADAEDLIQSTDPDSVQVSTKDMDSTLSRASRAIKKTSKKVTRAFSFTKTPKRVLQRAFMANGTPDERSPCPDADRMSRMSSSSTLAMSRSASTFSLTGSIKSAVVQRSNSLDHAPRPRVPVCVRTPCSPERADEPAAPKSQLRPSILSLPAVQPVAKCRDLLAPPEPGRRLPGSPRRETLL
InterPro domains: - IPR011993: PH-like domain superfamily (homologous_superfamily) [701-828]
- IPR000219: Dbl homology domain (domain) [486-675]
- IPR001357: BRCT domain (domain) [173-357]
- IPR049396: ECT2, BRCT0 domain (domain) [94-174]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [46-360]
- IPR001331: Guanine-nucleotide dissociation stimulator, CDC24, conserved site (conserved_site) [623-648]
- IPR026817: Guanine nucleotide exchange factor Ect2 (family) [28-943]
- IPR049395: ECT2, PH domain (domain) [701-826]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [461-694]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0022402 (cell cycle process), GO:0051301 (cell division), GO:0032506 (cytokinetic process), GO:0000910 (cytokinesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: carbonic anhydrase (F8W4I7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MDHIWTTLAFSFVLKCVECSGSATKWTYTGAVGQPEWIEFFPECGGFNQSPVNVDTSQTLHDPTLIPVQPMGYNQPGRRPFILSNNGHTVQMTLPHWMGVGGLPSHYSAVQLHLHWGNGVGIATGSEHTINGQSTSAELHIVHYNTEVYANLSEAMMQKNGLAVLGILIETGEEVNQAYGSIFNYLGRIRYAGQKVAIPSFDLQSLLPENLSQYFRYNGSLTTPPCHESVLWTIFNERVKISHSQLLKLETVLYSSKAEEEEPTILQDNYRATQPLNHRTVLSSFIPVSVQIYTAGEIAAIVIGSLFGCIGLAVIIWFIVKTIRLTSSWDVLQSIQPAPQPRMQDANEHKQDTDLKMTSNQEKTKDTEHQPET
InterPro domains: - IPR023561: Carbonic anhydrase, alpha-class (family) [24-280]
- IPR036398: Alpha carbonic anhydrase domain superfamily (homologous_superfamily) [21-300]
- IPR001148: Alpha carbonic anhydrase domain (domain) [24-285]
Interaction partners: - Actin filament-associated protein 1-like 1
- Neurexophilin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity), GO:0004089 (carbonate dehydratase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Acyl-CoA synthetase long chain family member 4b (A5WV15)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MTTAARPTFEPARGGRGKGEGDLSALSKQYSSRDLPGHTKIKYRQPTQDAPEEVRARDFRRELEERERAAVKGRDRGAREHTTSSSSSSSSSSSKRPRLDQIPAANLDADDPLTDDEDDSGSDSDSDDDTAALLAELEKIKKERAEEQERKEREQKAEEERIRMENILSGNPLLNLAGQQQQQQQQQQQQTQTKNTFSVKRRWDDDVVFKNCAKGVDESRKEKRFVNDTLRSEFHKKFMEKYVK
InterPro domains: - IPR006973: Pre-mRNA-splicing factor Cwf15/Cwc15 (family) [1-244]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Ubiquitin carboxyl-terminal hydrolase (Q4V973)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MTEVSEILMSVLSAIRVPRPGDRVHKDECAFSFSSPESEGGLYVCMNSFLGFGSKYVDRHHAKTGQRAYLHITRTRKTQKEDDPNSGSGDPPKKKPTRLAIGIEGGFDVEQEQYEEEVKVVLFPDRQEVTLDDLSSMPDVVRERVSLSVAELQAADSVSHTLQVQQWDGEVRQESKHAAELKQLDNGLKIPPSGWKCEVCELQENLWMNLTDGKVLCGRRYFDGSGGNNHALLYYQQTGYPLAVKLGTITPDGADVYSYDEDDMVLDSKLPEHLSHFGIDMMTMEKTERTMTELEIAVNQRVGEWEVIQESGTTLRPLWGPGLTGMKNLGNSCYLNSVMQVLFTIPDFQTKYVSNIDKIFDEAPSDPTQDFKTQVAKLGYGLLSGEYSKPAPDPADEPNTSAEPRGDQVGIAPRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNCRSGMNPSEAFRFLVEEKIVCQQSQKAKYTQRVDYIVQLPVPMDQATNMDELQEAERRREEAESSGAPPPVAPRAQIPFAACLAALSEPETLTDFWSSAVQAKTTATKTTRFASFPDHLVIQIKKFTFGLDWVPKKLDVSIDVPETLDLNALRAMGQQPGEELLPEVAPPPLMTPDVEVKAPVLDDSTVSQLCEMGFPLEACRKAVYYTGNTGIDAAMNWVMGHMDDPDFAAPLVLPGSSSAPGTTPTESLPEEHLATIVSMGFSRDQATRALKATNNVLERAVDWIFSHLDDLESMDVSEGGRSEGGSEASREPPPGPRVRDGTGKYELFAFISHMGSSTMCGHYVCHIKKDQQWVIFNDQKVCASEKPPKDLGYLYFYRRVVE
InterPro domains: - IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [324-832]
- IPR015940: Ubiquitin-associated domain (domain) [632-739]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [325-795]
- IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [179-832]
- IPR016652: Ubiquitinyl hydrolase (family) [15-832]
- IPR001607: Zinc finger, UBP-type (domain) [173-281]
- IPR009060: UBA-like superfamily (homologous_superfamily) [685-744]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [320-832]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [324-829]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [2-268]
- IPR041432: Ubiquitinyl hydrolase, variant UBP zinc finger (domain) [15-77]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:1990380 (K48-linked deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:1904888 (cranial skeletal system development), GO:0003002 (regionalization), GO:0009953 (dorsal/ventral pattern formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: P2X purinoceptor (A0A8M9PCJ8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Extracellular ATP-activated non-selective cation channel. Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization
Subcellular location: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein
Sequence: MQQCSGKMWTCITDFFTYETTKSVVVKSWTIGIINRVVQLLIITYFIGWVFLYEKAYQVRDTAIESSVMTKVKGFGEYNNRIMDVADYVTPTQGASVFCVITKLITTENQVQGNCPESELKFKCENDIRCKQLMTKPSSNGLLTGRCVHFNTTHKTCEIKGWCPAEIDEVQPNPMMEVENFTIFIKNSIRFPRFNFTKGNFLANINSSYIKGCNFDFERNMYCPIFKVGDVIRFAQQNFTTLATKGGVIGIKIAWVCDLDKADDECKPAYSFTRLDAMSEKTTVSPGYNFRYAKYFKMENGTEYRTLLKAYAIRFDVLVNGDAGKFDMIPTLINMVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVSDSNIQSSGSLYRTRDHSQQSIKTDEKFSNDSGAFSIERYS
InterPro domains: - IPR059116: ATP P2X receptor-like (family) [9-378]
- IPR053792: ATP P2X receptor, conserved site (conserved_site) [246-272]
- IPR027309: P2X purinoreceptor extracellular domain superfamily (homologous_superfamily) [61-338]
- IPR003046: P2X3 purinoceptor (family) [76-410]
- IPR001429: P2X purinoreceptor (family) [8-391]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0035381 (ATP-gated ion channel activity), GO:0004931 (extracellularly ATP-gated monoatomic cation channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: DIRAS family, GTP-binding RAS-like 1b (A0A8N7UYZ0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Displays low GTPase activity and exists predominantly in the GTP-bound form
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Sequence: MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTVEDTYRQVISCDKSVCTLQITDTTGSHQFPAMQRLSISKGHAFILVYSITSKQSLEELKPIYQQILAIKGNVENIPIMLVGNKSDETQREVKTEDGEAQSKTWKCAFMETSAKTNHNVTELFQELLNLEKKRSMSLNIDGKRSGKQSRADKLKGKCSVM
InterPro domains: - IPR001806: Small GTPase (family) [3-198]
- IPR020849: Small GTPase, Ras-type (family) [7-180]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-176]
- IPR005225: Small GTP-binding domain (domain) [6-164]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0021675 (nerve development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0061548 (ganglion development), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0021545 (cranial nerve development), GO:0061550 (cranial ganglion development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Peptide-methionine (R)-S-oxide reductase (A0A8M1P8M4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues
Sequence: MAVRLLRSMAPCASMALLQCMRSHKTTRPLLILTTPAALGTCRSKKTWPKTFPEEELRKRLTPMQYHVTQQKGTESAFTGKYVDNKEEGTYHCVVCGAPLFMSEKKFDSGSGWPSFFDLINKDAIAQTDDFSYGMHRVETTCSQCGAHLGHLFDDGPRPTKKRYCINSASLSFQPKNSATEEVEASGAAGQSSTSKNEEL
InterPro domains: - IPR002579: Peptide methionine sulphoxide reductase MrsB domain (domain) [44-180]
- IPR011057: Mss4-like superfamily (homologous_superfamily) [52-181]
- IPR028427: Peptide methionine sulfoxide reductase MsrB (family) [23-183]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0048513 (animal organ development), GO:0048839 (inner ear development), GO:0007423 (sensory organ development), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Uncharacterized protein LOC751650 (Q0P4F1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MAFPVDILTNVDHESLEQAAEEYMSQLPYRKPEYLILPNSKQIEIGLCNVSFVPLYGADTKKKILALFSPDDSITVVGLYLLGKWWGVEEVLKTAEPSRTGLIKVSTLGERIVLYVLNRIVLRNEKSGEEVFFLCHGEHESAKILWKDGVAIGFYSFKPKGSLCKNFVTQCYQLPVMDTVFVRKCHRGKDHGVKILEDFVCSFRNEDTGLKFPVSEAMYKVCEKYLRIYPADKEFLWEVENTGGFFQRTLIAKRLQGLKQKEKDHVVSKLIFAEEDATAPMEIEITKIQETTESTVEIEEKIPAVEVENDDATEKATKEIKKMTNEEINLAGETDIEMCSLVHEQDIHAPVSTEISLRHRTIKVTSTPIKKSGRVQKREDEVVVEHQARHTLMSKKKNRNNLSYRRET
InterPro domains: - IPR029625: Protein FAM169 (family) [1-402]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0061733 (peptide-lysine-N-acetyltransferase activity), GO:0004402 (histone acetyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016407 (acetyltransferase activity), GO:0016410 (N-acyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: E3 ubiquitin-protein ligase MARCHF5 (A3KP58)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein
Sequence: MAEEGAVVMQQIVDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQSCLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEASPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNFPEPEEA
InterPro domains: - IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [4-77]
- IPR011016: Zinc finger, RING-CH-type (domain) [9-78]
Interaction partners: - Mitofusin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)
Protein: Sialidase-1 (Q1LWP9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage
Subcellular location: Cell membrane. Cytoplasmic vesicle. Lysosome lumen. Lysosome membrane; Peripheral membrane protein; Lumenal side
Sequence: MDFIRQIGILLGIAVLSSARADKTQIDPLIYEEQLLWVSGGAGQVNAYRIPLLTFTLRGSLLAFSEARKMSSSDIGAKFIALRRSTDRGATWSPTSFIVDDGSLADGLSLGSVVVDEETGAVIIIYSLCFHQYQCSPSSTMMVQSLDDGFTWSVPRNLSIELGVKSFAPGPGFGIQKRYPPSKGRLVVCGHGTIAGDGVFCILSDDHGRSWRYGAALKSIPYNQPKQDLDFNPDECQPVELEDGSIVINVRNQNNYHCRCRIIVRSLDGGESLPVEELVFDKTLIDPVVAAGALQKQGVMYFTNPSSTQHRVNLTLRWSFTDGKSWEKEAVQIWAGPSGYSTMTSLKGGSAEDNKYIFVVYEKGHKDYWETISFAKIHLYGGK
InterPro domains: - IPR026856: Sialidase family (family) [28-381]
- IPR036278: Sialidase superfamily (homologous_superfamily) [33-379]
- IPR011040: Sialidase (domain) [59-349]
Interaction partners: - Alpha-galactosidase
- Galactocerebrosidase
- General transcription and DNA repair factor IIH helicase/translocase subunit XPB
- N-acylneuraminate cytidylyltransferase B
- N-acylneuraminate cytidylyltransferase A
- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
- exo-alpha-sialidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0016997 (alpha-sialidase activity), GO:0004308 (exo-alpha-sialidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)