wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Histone H2A type 3 (H2A-clustered histone 25) (Q7L7L0)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Sequence: MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [2-130]
- IPR002119: Histone H2A (family) [3-123]
- IPR007125: Histone H2A/H2B/H3 (domain) [5-89]
- IPR032454: Histone H2A, C-terminal domain (domain) [92-126]
- IPR032458: Histone H2A conserved site (conserved_site) [22-28]
Interaction partners: - Histone H2B type 2-E
- Histone H2B type 3-B
- Histone H4
- Histone H1.1
- Histone H2B type 1-A
- Ubiquitin-ribosomal protein eS31 fusion protein
- Histone H3.1
- Histone H2B type 1-J
- Histone H2B type 1-K
- Histone H2B type 1-D
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)
Protein: Mitogen-activated protein kinase (EC 2.7.11.24) (Q8X1A2)
Organism: Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MSRANPPNAAGSRKISFNVSEQYDIQDVVGEGAYGVVCSAIHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQKPRSYESFQEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASQEDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKVPFRTLFPKTSDLALDLLEKLLAFNPVKRITVEEALKHPYLEPYHDPEDEPTAPPIPEEFFDFDKHKDNLSKEQLKQLIYQVIMW
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [16-320]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [143-155]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [22-325]
- IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [57-159]
- IPR017441: Protein kinase, ATP binding site (binding_site) [29-53]
- IPR000719: Protein kinase domain (domain) [23-311]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050793 (regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0000165 (MAPK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2) (P97493)
Organism: Mus musculus (Mouse)
Function: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Subcellular location: Mitochondrion.
Sequence: MAQRLLLGRFLTSVISRKPPQGVWASLTSKTLQTPQYNAGGLTVMPSPARTVHTTRVCLTTFNVQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLAIKNGDVVDKFVGIKDEDQLEAFLKKLIG
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [63-165]
- IPR017937: Thioredoxin, conserved site (conserved_site) [82-100]
- IPR013766: Thioredoxin domain (domain) [41-166]
- IPR005746: Thioredoxin (family) [69-163]
Interaction partners: - Thioredoxin-interacting protein
- Thioredoxin reductase 2, mitochondrial
- Thioredoxin
- Thioredoxin-dependent peroxide reductase, mitochondrial
- Peroxiredoxin-5, mitochondrial
- Mitogen-activated protein kinase kinase kinase 5
- 3-mercaptopyruvate sulfurtransferase
- Thioredoxin reductase 1, cytoplasmic
- Peroxiredoxin-1
- Mitochondrial peptide methionine sulfoxide reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0019725 (cellular homeostasis), GO:0045454 (cell redox homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein IQ-DOMAIN 3 (AtIQD3) (Q9FT53)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity). Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity). May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Nucleus, nucleolus {ECO:0000269|PubMed:28115582}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28115582}.
Sequence: MGKSWFSAVKKALSPEPKQKKEQKPHKSKKWFGKSKKLDVTNSGAAYSPRTVKDAKLKEIEEQQSRHAYSVAIATAAAAEAAVAAAQAAAEVVRLSALSRFPGKSMEEIAAIKIQTAFRGYMARRALRALRGLVRLKSLVQGKCVRRQATSTLQSMQTLARVQYQIRERRLRLSEDKQALTRQLQQKHNKDFDKTGENWNDSTLSREKVEANMLNKQVATMRREKALAYAFSHQNTWKNSTKMGSQTFMDPNNPHWGWSWLERWMAARPNENHSLTPDNAEKDSSARSVASRAMSEMIPRGKNLSPRGKTPNSRRGSSPRVRQVPSEDSNSIVSFQSEQPCNRRHSTCGSIPSTRDDESFTSSFSQSVPGYMAPTQAAKARARFSNLSPLSSEKTAKKRLSFSGSPKTVRRFSGPPKLESNVTKKDTNLA
InterPro domains: - IPR000048: IQ motif, EF-hand binding site (binding_site) [106-128]
Interaction partners: - Receptor protein kinase-like protein At4g34220
- Probable protein phosphatase 2C 64
- Leucine-rich repeat receptor-like protein kinase PXC2
- Probable inactive receptor kinase At5g16590
- Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM2
- Probable LRR receptor-like serine/threonine-protein kinase IRK
- Receptor-like protein kinase At5g59670
- Tryptophan aminotransferase-related protein 4
- Mitochondrial import inner membrane translocase subunit PAM16 like 1
- Tryptophan aminotransferase-related protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0051592 (response to calcium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9FN35)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MEATPVFNYHIDVNPERKKIGTIQVYVSFVGSANMSPILTRSNFSCSLPANELTDDEDSPHKQRLYYFLTDSAVDSQDAYTLILKLTQLARDLTSNSFEYCPRYALSVWLTLDVAPLNEYERNSEYRPASNLRVGALSRRIYKRKQKTSSIANKSTRYMRKRETYSSGEYKCAICFQEFKTGREVATLLCGHEFDNKCIMEWFKVRYNCPLCRFELPREDDHIPQRTTDL
InterPro domains: - IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [135-219]
- IPR001841: Zinc finger, RING-type (domain) [171-213]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048583 (regulation of response to stimulus), GO:0009605 (response to external stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0010646 (regulation of cell communication), GO:0045087 (innate immune response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0009966 (regulation of signal transduction), GO:0009682 (induced systemic resistance), GO:2000022 (regulation of jasmonic acid mediated signaling pathway), GO:0042742 (defense response to bacterium), GO:2000031 (regulation of salicylic acid mediated signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Splicing factor, arginine/serine-rich 19 (CTD-binding SR-like protein rA1) (SR-related and CTD-associated factor 1) (Q63624)
Organism: Rattus norvegicus (Rat)
Function: May function in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MEEEDESRGKTEESGEDRGDGPPDRDPALSPSAFILRAIQQAVGSSLQGDLPNDKDGSRCCGLQWRRCCRSPRSEPRSQESGGADMATVLDTAADSFLVELVSILDPPDTWVPSHLDLQPGESEDVLELVAEVRIGDRDPMPLPVPSLLPRLRAWRTGKTVSPQSHASRPACSRHLLTLGTGDGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPPPPALPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDDSPHREPPPPQTLGAPGTPPQADSTRAEGAPRRRVFVVGPEAEACLEGKVSVEVVTTAGGPALPLPPLPPTDPEIEEGEIVQPEEEPRVAVSLFRAARPRQPPASVATLASVAAPAAPPASAPRAPEGDDFLSLHADSDGEGALQVDLGEPPAPPAADARWGGLDLRRKILTQRRERYRQRSASPGPPPARKKARRERQRSGDPAPPDSPTWEAKKHRSRERKLGSHSTARRRSRSRSRRRSRSRSADRRRGSHRSRSREKRRRRRRSASPPPAASSSSSSRRERHRGKRREGGKKKKKRSRSRAEKRSGDLEKLPAPVPPSGSDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRPDKTEPRAPSPAPAVSPKREVLYDSEGLSADERGAKGDKDRRRSGAASSSSSSREKASRRKALDGDRGRDRDRSSKKTRPPKDSAPGSGALPKAPPSSGSSSSSSSCSSRKVKLQSKVAVLIREGVSSTTPAKDSSSSGLGSIGVKFSRDRESRSPFLKPDERAPAEGVKVAPGSTKPKKTKAKAKAGAKKAKGTKGKTKPSKTRKKVRSGGSSTASGGPGSLKKSKADSCSQAASAKGTEETSWSGEERTTKAPSTPPPKVAPPPPALTPDSQTVDSSCKTPEVSFLPEEASEDTGVRVGAEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPAARASQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSTLGVTPAPVPTSLGLPPGPSSYLLPGSLPIGGCGSTPPTPTGLVPASDKREGSSSSEGRGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINPVKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL
InterPro domains: - IPR057031: SCAF11-like, C-terminal domain (domain) [1154-1225]
- IPR042841: Splicing factor, arginine/serine-rich 19 (family) [1-1255]
Interaction partners: - Ets2 repressor factor
- Proline rich 12
- Protein PRRC2A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:1901652 (response to peptide), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Chromosome partition protein MukE (Protein KicA) (P22524)
Organism: Escherichia coli (strain K12)
Function: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
Subcellular location: Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Sequence: MSSTNIEQVMPVKLAQALANPLFPALDSALRSGRHIGLDELDNHAFLMDFQEYLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPERLANEGIFTQQELYDELLTLADEAKLLKLVNNRSTGSDVDRQKLQEKVRSSLNRLRRLGMVWFMGHDSSKFRITESVFRFGADVRAGDDPREAQRRLIRDGEAMPIENHLQLNDETEENQPDSGEEE
InterPro domains: - IPR042038: MukE, N-terminal domain (homologous_superfamily) [1-78]
- IPR042037: MukE, C-terminal domain (homologous_superfamily) [88-195]
- IPR007385: Prokaryotic chromosome segregation/condensation protein MukE (family) [10-234]
Interaction partners: - Chromosome partition protein MukF
- Chromosome partition protein MukB
- tRNA 5-carboxymethoxyuridine methyltransferase
- Methylmalonyl-CoA decarboxylase
- Macrodomain Ter protein
- Methylmalonyl-CoA mutase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006301 (postreplication repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0042575 (DNA polymerase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005634 (nucleus)
Protein: Transcription regulator, AsnC family (Q92LT2)
Organism: Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Function: Not known
Sequence: MELLDGFDLKILSELQRDGHLTNNELSERVALSPSQCSRRRTRLEAEGFITGYQAQIDRQKLGLDLMVVISVTLATHNRDNAKRFANLVSALPEVLEAYALTGEMDYHLRVVTPDLAGLSRFVNEVLLPHDSVQHVKTSIVLETLKSFEGLPIPARMKG
InterPro domains: - IPR011008: Dimeric alpha-beta barrel (homologous_superfamily) [64-152]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [3-63]
- IPR019887: Transcription regulator AsnC/Lrp, ligand binding domain (domain) [71-144]
- IPR011991: ArsR-like helix-turn-helix domain (domain) [3-55]
- IPR000485: AsnC-type HTH domain (domain) [4-65]
- IPR019888: Transcription regulator AsnC-like (family) [4-113]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [5-55]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Protein BUD31 homolog (Protein EDG-2) (Protein G10 homolog) (P41223)
Organism: Homo sapiens (Human)
Function: Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:25091737, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. Note=Detected in chromatin at the promoter of AR target genes. {ECO:0000305|PubMed:25091737}.
Sequence: MPKVKRSRKAPPDGWELIEPTLDELDQKMREAETEPHEGKRKVESLWPIFRIHHQKTRYIFDLFYKRKAISRELYEYCIKEGYADKNLIAKWKKQGYENLCCLRCIQTRDTNFGTNCICRVPKSKLEVGRIIECTHCGCRGCSG
InterPro domains: - IPR018230: BUD31/G10-related, conserved site (conserved_site) [100-143]
- IPR001748: Pre-mRNA-splicing factor BUD31 (family) [1-143]
Interaction partners: - Pre-mRNA-splicing factor CWC22 homolog
- Pre-mRNA-processing-splicing factor 8
- Crooked neck-like protein 1
- U2 small nuclear ribonucleoprotein A'
- Small nuclear ribonucleoprotein G
- Pleiotropic regulator 1
- Pre-mRNA-processing factor 19
- Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein Sm D2
- Pre-mRNA-processing factor 17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)