Protein: Major sperm protein isoform beta (Beta-MSP) (P27440)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Subcellular location: Cell projection, pseudopodium. Cytoplasm, cytoskeleton.
Sequence: MAQSVPPGDINTQPGSKIVFNAPYDDKHTYHIKITNAGGRRIGWAIKTTNMRRLGVDPPCGVLDPKESVLMAVSCDTFNAATEDLNNDRITIEWTNTPDGAAKQFRREWFQGDGMVRRKNLPIEYNL
InterPro domains: - IPR051155: Nematode Major Sperm (family) [1-126]
- IPR000535: Major sperm protein (MSP) domain (domain) [9-126]
- IPR008962: PapD-like superfamily (homologous_superfamily) [5-126]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [2-127]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009994 (oocyte differentiation), GO:0001556 (oocyte maturation), GO:0071695 (anatomical structure maturation), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043410 (positive regulation of MAPK cascade), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)