Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (A8K3M3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}. Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}.
Sequence: MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1-298]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [189-268]
- IPR012265: Protein-tyrosine phosphatase, non-receptor type-1/2 (family) [3-432]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [170-276]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [213-223]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [3-279]
- IPR051985: Non-receptor type tyrosine-specific phosphatase (family) [1-428]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0005102 (signaling receptor binding), GO:0043169 (cation binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0046872 (metal ion binding), GO:0045296 (cadherin binding), GO:0046875 (ephrin receptor binding), GO:0004725 (protein tyrosine phosphatase activity), GO:0019900 (kinase binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0003723 (RNA binding), GO:0030971 (receptor tyrosine kinase binding), GO:0016791 (phosphatase activity), GO:0046914 (transition metal ion binding), GO:0019901 (protein kinase binding), GO:1990782 (protein tyrosine kinase binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0030029 (actin filament-based process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0060759 (regulation of response to cytokine stimulus), GO:0009968 (negative regulation of signal transduction), GO:1905898 (positive regulation of response to endoplasmic reticulum stress), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0009725 (response to hormone), GO:0006793 (phosphorus metabolic process), GO:0009894 (regulation of catabolic process), GO:0030968 (endoplasmic reticulum unfolded protein response), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0035966 (response to topologically incorrect protein), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:1903573 (negative regulation of response to endoplasmic reticulum stress), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:1901652 (response to peptide), GO:0031347 (regulation of defense response), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0051246 (regulation of protein metabolic process), GO:0070201 (regulation of establishment of protein localization), GO:1905897 (regulation of response to endoplasmic reticulum stress), GO:1900102 (negative regulation of endoplasmic reticulum unfolded protein response), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0032386 (regulation of intracellular transport), GO:0071417 (cellular response to organonitrogen compound), GO:0030100 (regulation of endocytosis), GO:0043086 (negative regulation of catalytic activity), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:0051248 (negative regulation of protein metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0031532 (actin cytoskeleton reorganization), GO:0006796 (phosphate-containing compound metabolic process), GO:0032880 (regulation of protein localization), GO:1902532 (negative regulation of intracellular signal transduction), GO:0036211 (protein modification process), GO:0043434 (response to peptide hormone), GO:0034976 (response to endoplasmic reticulum stress), GO:0032870 (cellular response to hormone stimulus), GO:0035967 (cellular response to topologically incorrect protein), GO:0010243 (response to organonitrogen compound), GO:0051247 (positive regulation of protein metabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0006986 (response to unfolded protein), GO:0051338 (regulation of transferase activity), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:1900101 (regulation of endoplasmic reticulum unfolded protein response), GO:1903894 (regulation of IRE1-mediated unfolded protein response), GO:0031400 (negative regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0034620 (cellular response to unfolded protein), GO:0006470 (protein dephosphorylation), GO:0060416 (response to growth hormone), GO:0007010 (cytoskeleton organization), GO:0043549 (regulation of kinase activity), GO:0051348 (negative regulation of transferase activity), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0031401 (positive regulation of protein modification process), GO:0043409 (negative regulation of MAPK cascade), GO:0016311 (dephosphorylation), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0071375 (cellular response to peptide hormone stimulus), GO:0033157 (regulation of intracellular protein transport), GO:0019220 (regulation of phosphate metabolic process), GO:1901653 (cellular response to peptide), GO:0060338 (regulation of type I interferon-mediated signaling pathway), GO:0045936 (negative regulation of phosphate metabolic process), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0071378 (cellular response to growth hormone stimulus), GO:0060396 (growth hormone receptor signaling pathway), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0048008 (platelet-derived growth factor receptor signaling pathway), GO:0035335 (peptidyl-tyrosine dephosphorylation), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0033673 (negative regulation of kinase activity), GO:0043407 (negative regulation of MAP kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0061097 (regulation of protein tyrosine kinase activity), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0045860 (positive regulation of protein kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity), GO:0061098 (positive regulation of protein tyrosine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0098554 (cytoplasmic side of endoplasmic reticulum membrane), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)