Protein: Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor) (P30560)
Organism: Rattus norvegicus (Rat)
Function: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Located in cytoplasmic vesicles dispersed throughout the cell cytoplasm and to the plasma membrane.
Sequence: MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
InterPro domains: - IPR001224: Vasopressin V1A receptor (family) [6-387]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [68-354]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [53-362]
- IPR015076: Vasopressin V1 receptor, C-terminal (domain) [378-424]
- IPR001817: Vasopressin receptor (family) [46-349]
Interaction partners: - Vasopressin-neurophysin 2-copeptin
- Oxytocin-neurophysin 1
- Guanine nucleotide-binding protein G
- Vasopressin V2 receptor
- Vasopressin V1b receptor
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-12
- Guanine nucleotide-binding protein subunit alpha-13
- Angiotensinogen
- Pro-opiomelanocortin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051050 (positive regulation of transport), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0046887 (positive regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0010817 (regulation of hormone levels), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0046883 (regulation of hormone secretion), GO:1903532 (positive regulation of secretion by cell), GO:0061458 (reproductive system development), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0002793 (positive regulation of peptide secretion), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0008584 (male gonad development), GO:0002791 (regulation of peptide secretion), GO:0043410 (positive regulation of MAPK cascade), GO:0060123 (regulation of growth hormone secretion), GO:0043949 (regulation of cAMP-mediated signaling), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0097447 (dendritic tree), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0030425 (dendrite)