Protein: phosphatidylinositol-4,5-bisphosphate 3-kinase (EC 2.7.1.153) (O42391)
Organism: Gallus gallus (Chicken)
Function: Not known
Sequence: MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLLTIKHELFKEARKYPLYQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPICEFDMVKDPEVQDFRRNILNVCKEAVDLRDANAPHSRALYVCPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYTQLPLDTFTMPSYSRRISTATPYMNGEATAKSLWTINSALRIRILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLSYDMYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINMFDYTDTLVSGKMALNLWAVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSNPVKFPDMTVIEEHANWTISRELGFNYSYAGLSNRIARDNELRESDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVNTPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNQLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFISPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEMYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [519-696]
- IPR035892: C2 domain superfamily (homologous_superfamily) [327-478]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [700-1060]
- IPR015433: Phosphatidylinositol 3-/4-kinase (family) [54-1064]
- IPR000341: Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain (domain) [173-292]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [106-296]
- IPR002420: C2 phosphatidylinositol 3-kinase-type domain (domain) [322-487]
- IPR003113: Phosphatidylinositol 3-kinase, adaptor-binding domain (domain) [16-108]
- IPR037704: Phosphatidylinositol 3-kinase alpha, catalytic domain (domain) [695-1064]
- IPR042236: Phosphoinositide 3-kinase, accessory (PIK) domain superfamily (homologous_superfamily) [479-695]
- IPR018936: Phosphatidylinositol 3-/4-kinase, conserved site (conserved_site) [801-920]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [853-1051]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [765-1065]
- IPR001263: Phosphoinositide 3-kinase, accessory (PIK) domain (domain) [518-704]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0052742 (phosphatidylinositol kinase activity), GO:0035004 (phosphatidylinositol 3-kinase activity), GO:0016303 (1-phosphatidylinositol-3-kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0006644 (phospholipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0060491 (regulation of cell projection assembly), GO:0006650 (glycerophospholipid metabolic process), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0008654 (phospholipid biosynthetic process), GO:1902745 (positive regulation of lamellipodium organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010592 (positive regulation of lamellipodium assembly), GO:0046474 (glycerophospholipid biosynthetic process), GO:1902743 (regulation of lamellipodium organization), GO:0010591 (regulation of lamellipodium assembly), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0046488 (phosphatidylinositol metabolic process), GO:0046854 (phosphatidylinositol phosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)