Protein: Nidogen (Q93791)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Sequence: MKHKKMLILLFLYLLIETTTANPAFYPYGQPAGDNRLDYSMEQSAIALKIPLTYMEQSVDELFLSHNGIVGLGKPTPEKIGGLMTISTPAIAVFYVPVTSGVIDYRVSSDDQGLLTKLTQDVKQVFADAVEFHGLQAVIITWTQIENAEKDGPASFQLAIVSDGISTYAIFRYESLPWSSSMGYYAQAGFVRSIGKIQTNVNSGGPDVKELVNLSNNQFGNFFIFRVSGSAIEDPKDEGADDYDYNNYDQEYEGEHPADCPKDKFVDNCPAECRTVRDERGCERCICAERPHAPRAPQEPRPELENTVEDDEDDEQVDGTRYEEPARQAQEQHHQQHHQPDQPQQQPQRSQEGSLPKMSCSQRDDKSCHANSVCQDFEGGFCCNCDTGFYGNGKECLPKGEPQRISGSFEGVINRIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFADVQSPNVYNGFQLTGGLFNRTVALHIEQNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIVRDGGNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNFATRSVGPAVSAPSGGHFDRRQHGQSNMASERPIEIPSQSESISTDSVCAPGRHQCTLPNMKCRVVDPSYRCECEPGYQAAHDASSHIGWICQDLDECQRGDHNCDQHAKCTNRPGSFSCQCLQGYQGDGRSCIREHQASHHEHNQQTPQEMAGVGATTEGFCTAHNQCHQWGECVFTSEHPTGRCKCRGWYVGDGVNHCGPPEENMPKHNANIPQRGGQACGSYVCDVNAECMPEPSGGSECVCKAGFSGNGVTCESLLDDRHAHSSHNRHEQQQQTGSLGKVCRSHDECSEHGSCAYHHSLGYYQCACTEPYVGNGVECTLPGSSASAPELGCDVTRDCSEFADCVYERSSTGATFRCVCQSGYTGDGKYCMQSQLAISAISPSVPQLPSEPAVLSTASCNPNCGPDAQCVYDDHNRQYRCECYAAFMGDGYNCVPLAKPNMVPAQPKTCVESSDCHINGHCVINEHGAGEYICQCLPGFSGDGFINCRGADQCNPSNPSACYQNAHCVYDAILNAHACKCVDGFKGDGTSCVPYAPATNCNLEPRICHANAQCVMHHDTNAYECICKPGSSGDGYTKCDVIETPRCTNCSIHAYCAQNPTSGAYQCKCNAGYNGNGHLCVSMSSCLDDRSLCDENADCVPGEAGHYVCNCHYGYHGDGRSCSPESSTRSDKLLVARGMAIFERSTNPDEYGKQLIVIPHHIPVGIDFDCKEEKIVWSDMSGHSIRTSSLNGTEHKSYFNKELSSPEGIAVDWSSRNVYYADSMNDEIGVASLNGKFKKSLVTEGLVNPRSVVLDLYGRHLYYSDWHRENPYIGRVDMDGKNNRVFLNEDVHLPNGLTILPNRRELCWVDAGNHRLSCIQYNGAGRRTVFSSLQYPFGLTHDEEQKFYWTDWKDNRIHSVGVYGEGYRSFQISLGGSGKVFGILAVPKSCVGPSTPCSEDNGGCQHLCLPGQNGAVCECPDNVKVKGC
InterPro domains: - IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [1288-1549]
- IPR009017: Green fluorescent protein (homologous_superfamily) [368-617]
- IPR001881: EGF-like calcium-binding domain (domain) [360-1279]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [708-734]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [725-736]
- IPR000033: LDLR class B repeat (repeat) [1309-1523]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [663-695]
- IPR050778: Cueball/EGF/LRP/Nidogen (family) [1206-1583]
- IPR024731: NELL2-like, EGF domain (domain) [712-747]
- IPR000742: EGF-like domain (domain) [359-1279]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [662-815]
- IPR006605: G2 nidogen/fibulin G2F (domain) [398-629]
- IPR003886: NIDO domain (domain) [61-232]
Interaction partners: - Fibronectin type-III domain-containing protein
- Basement membrane proteoglycan
- Collagen alpha-2
- Dystroglycan 1
- Collagen alpha-1
- Laminin-like protein epi-1
- SPARC
- Agrin
- Laminin-like protein lam-2
- Metalloprotease mig-17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005201 (extracellular matrix structural constituent)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0007154 (cell communication), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0099536 (synaptic signaling), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016477 (cell migration), GO:0022008 (neurogenesis), GO:0008104 (protein localization), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0034330 (cell junction organization), GO:0099537 (trans-synaptic signaling), GO:0050808 (synapse organization), GO:0098916 (anterograde trans-synaptic signaling), GO:1902414 (protein localization to cell junction), GO:0048699 (generation of neurons), GO:0035418 (protein localization to synapse), GO:0007268 (chemical synaptic transmission), GO:0007271 (synaptic transmission, cholinergic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0005604 (basement membrane)