Protein: Katanin-interacting protein (Q8C753)
Organism: Mus musculus (Mouse)
Function: May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:O60303}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:O60303}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O60303}. Note=When overexpressed, localizes to the cytoplasm where it associates with acetylated alpha-tubulin. {ECO:0000250|UniProtKB:O60303}.
Sequence: MDGQALRKVERSRSCSQERKEGYSKDMVTDFDEKHDEYLILLQQRNRILKHLKAKDPVQLRLEHLEQGFSVYVNGANSELKTSPRKAVHTDFSRSASQAEGSQDYGRRTLFREAEEVLRRSSRTAPGKVQRRGWHQKSVQIRTEAGSRLHIEPPLDCSEDFESQEDVIGKHEDATGEHTQELRKGLGLSTSLQTQEDGSSDEYDSIEEDVLSETETEDPVLPVHNRDECPLPSHDAVQKDVPKDQELEGRHPQATDTLVVMEFNPASKGNKMDRILSAKRKENAEVFIPSKPDSVLNPQPPAVFPEQERACSRSGSRRDRPLSATRKAYAAEDREEDASAVLKAIQVENEALQQVFLSHDPELHTSPQQDTKEPPAKSWSSLLKAKEDIPELLPATPVTTDPELCRAAAGAKAVSQAMDGMSPLGSRQQHKLVGVLQTMESDTTHLSQVAIPTEKPVPNSEEKWKARVDEIEDAIYVTMEILSNWGNASWVGLTEVQFFDLNNIKLYVSPHDVDIRNAVLPGELGCLVNRDLVSKKDPPVWTCPFHPPLQLYFIIHNMRQLRDFGLTMIKVRNYWTADGDLDIGAKNVKLYVNKSLIFDGVLEKGGGEAPSDCTIPVDLQRERNESSDKALSTGWKESKGALKMAALSDARELGLSCSQPAESLDMTVSSQGDFLGEKVNSTSGLKNSLSKLQEDVRLLATPASMGDGPSVPSSSSPGKCLPLEEEPSLIQQLESLRGRKIPEPTGKTPHWLQPSLAGMGKKQTVRKPKPLWLSPEKDLEQKSRFPSEDVMGDTPGEVETREKGPRREQGRTSSWNVITEERAPKAFSKACGDDLDIFSQLPNRDRPASGRRALKKEASSSHGDDRPASKEDTQASQTLPWLQWYGEQEHALHASWDSLTAFDRAHRGRISALEPQGDILDEFLKQQRSSRHEEFPAPCREEEPEPSTEMGGDSDFKIPVLPYGQHLVIDIKSTWGDRHYVGLNGIEIFSSSGEPVQISSITADPPDINILPAYGKDPRVVSNLIDGVNRTQDDMHVWLAPFTPGMTHTISIEFTHPCQVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGEIAKASGTLMGAPEHFGDTILFTMDEDILEAIFCLDDTFDMDAESLCGLQPEEALRRPSTADGEGQDERPFTQAGLGAQDQVPGLELQTSPPVSEVTTPEPGIFYGLCLRLNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGLDHVVMIHFDRAQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILFGDYLQTRLPPAPTRRLDAKSLERASMDYEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEGVCGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGILAMVSHLVGGILPTCEPTVPHHTILFAEDTDFCHQEKHAIISKPEEDQDIQMMNENQVITTSRRKPGTADPALRPKTCIREKETSRRWRC
InterPro domains: - IPR027859: KATNIP domain (domain) [970-1523]
- IPR026704: Katanin-interacting protein (family) [36-1583]
Interaction partners: - Katanin p60 ATPase-containing subunit A-like 2
- Centrosomal protein of 104 kDa
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0098862 (cluster of actin-based cell projections), GO:0032421 (stereocilium bundle), GO:0120025 (plasma membrane bounded cell projection), GO:0032420 (stereocilium), GO:0098858 (actin-based cell projection), GO:0043005 (neuron projection)