wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Glutamate decarboxylase A (EC 4.1.1.15) (Q54VQ5)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Generates GABA from glutamate. GABA induces the release of acbA from prespore cells and induces the exposure of tagC on the surface of prestalk cells where it can convert acbA to SDF-2. Glutamate acts as a competitive inhibitor.
Sequence: MSLHHVKTNKYKGFYDSYASPPATKEISKYSLKEESNKPEVIRDLIIDELLLDGNAKQNLATFCQTDLDKEIHVLMDKCIDKNMIDKDEYPQTAEIESRCVHILADLWNSPESSETIGCSTTGSSEAAMLGGMALKWRWRENRKKQGKPFDKPNIVTGPVQICWHKFALYFDIELREVPMEHDRYIMTPEEAIKRCDENTIGVIPTLGVTFTLQYEDVKGISEALDKFEKETGLDIPIHVDAASGGFVAPFLQPEIVWDFRLPRVKSINGSGHKFGLSPLGVGWVVWRGKNDIHKDLVFDVNYLGGNMPTFSLNFSRPGGQIVCQYYNFLRHGRSGYTAVHQACLDHGIFISKQVKKHGIFDIVYDGTGALPGACWKLKKDAKVKFNLFDLSDRMRNRGWQIASYTLPNLPDIVVQRVLIRHGFSHDMAMLLIEDFNRSIEYFDKHPMVQSISKDEGQSFHH
InterPro domains: - IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [66-357]
- IPR010107: Glutamate decarboxylase (family) [1-449]
- IPR002129: Pyridoxal phosphate-dependent decarboxylase (family) [49-378]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [14-446]
Interaction partners: - 4-aminobutyrate aminotransferase
- Glutamate dehydrogenase, mitochondrial
- Glutamate dehydrogenase 2
- Pantoate--beta-alanine ligase
- Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
- Aldehyde dehydrogenase family 3 comG
- Aldehyde dehydrogenase
- Putative aldehyde dehydrogenase family 7 member A1 homolog
- Aldehyde dehydrogenase
- Cysteine dioxygenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0099120 (socially cooperative development), GO:0048856 (anatomical structure development), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0031152 (aggregation involved in sorocarp development), GO:0033554 (cellular response to stress), GO:0030587 (sorocarp development), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Phenylcoumaran benzylic ether reductase PT1 (PCBER-Pt1) (EC 1.23.1.-) (PtPCBER) (Q9LL41)
Organism: Pinus taeda (Loblolly pine)
Function: Oxidoreductase involved in lignan biosynthesis. Catalyzes the NADPH-dependent reduction of phenylcoumaran benzylic ethers. Converts dehydrodiconiferyl alcohol (DDC) to isodihydrodehydrodiconiferyl alcohol (IDDDC), and dihydrodehydrodiconiferyl alcohol (DDDC) to tetrahydrodehydrodiconiferyl alcohol (TDDC).
Sequence: MGSRSRILLIGATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSIDDHASLVEAVKNVDVVISTVGSLQIESQVNIIKAIKEVGTVKRFFPSEFGNDVDNVHAVEPAKSVFEVKAKVRRAIEAEGIPYTYVSSNCFAGYFLRSLAQAGLTAPPRDKVVILGDGNARVVFVKEEDIGTFTIKAVDDPRTLNKTLYLRLPANTLSLNELVALWEKKIDKTLEKAYVPEEEVLKLIADTPFPANISIAISHSIFVKGDQTNFEIGPAGVEASQLYPDVKYTTVDEYLSNFV
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [4-276]
- IPR050608: NmrA-type oxidoreductase, Isoflavone reductase subfamily (family) [4-308]
- IPR008030: NmrA-like domain (domain) [4-304]
- IPR045312: Phenylcoumaran benzylic ether reductase-like (domain) [6-303]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0050664 (oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009698 (phenylpropanoid metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009806 (lignan metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009699 (phenylpropanoid biosynthetic process), GO:0009807 (lignan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protease, serine, 32 (Q8R1A6)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MELALPAILFTFFPGVLLGSEVLPTDSDSPSTTTGRRSIDLDSVCGRPRTSGRIVSGQDAQLGRWPWQVSVRENGAHVCGGSLIAEDWVLTAAHCFNQGQSLSIYTVLLGTISSYPEDNEPKELRAVAQFIKHPSYSADEHSSGDIALVQLASPISFNDYMLPVCLPKPGDPLDPGTMCWVTGWGHIGTNQPLPPPFTLQELQVPLIDAETCNTYYQENSIPGTEPVILEGMLCAGFQQGKKDACNGDSGGPLVCDINDVWIQAGVVSWGSDCALFKRPGVYTNVSVYISWIQNTMWNLPMEGRGFSPSLSGTPLLGLLTSLSSAFFLLGP
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [80-254]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [45-298]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [90-95]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [243-254]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [40-298]
- IPR001254: Serine proteases, trypsin domain (domain) [53-297]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Homeobox protein Dlx6a (Distal-less homeobox protein 6a) (DLX-6) (Q98877)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Sequence: MMTMTTMADGLEAQDSSKSAFMEFGQQSHSQQSSPSMAASHYPLHCLHSGSHHHHQHDSSPYSGSNSYNRSLPYSYVSHPHHSPYLPSYHSNASGTQTRLDATEQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGGNPHETDTLPGSIALSPRSPAIPPIWDVSASSKGVNMSANSYMPGYSHWYSSPHQDAMQR
InterPro domains: - IPR001356: Homeodomain (domain) [123-187]
- IPR050460: Distal-less homeobox transcription factors (family) [13-247]
- IPR020479: Homeodomain, metazoa (domain) [147-181]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [122-186]
- IPR017970: Homeobox, conserved site (conserved_site) [158-181]
- IPR000047: Helix-turn-helix motif (conserved_site) [154-179]
Interaction partners: - Endothelin-1 receptor
- Heart- and neural crest derivatives-expressed protein 2
- Endothelin 1.
- Endothelin receptor type Ab
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0061448 (connective tissue development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Ribosomal protein S21 family protein (Q9LI88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MAASFSLTSFISFISPFKSQTKPTPPPNLTLPSPTISQRRRNDLAIESMAVEETSSTASSLSSELASVICPSLAYSNTLFFSSGYNVQVFVEDNESEERLVNRFRREVMRTGVIQECKRRRYFENKQDEKKRRTRDAAKRNKKRRPQARFTQETREEAAAATKSKKKDEEEDNWEMPGGDVPS
InterPro domains: - IPR001911: Small ribosomal subunit protein bS21 (family) [1-182]
- IPR038380: Small ribosomal subunit protein bS21 superfamily (homologous_superfamily) [102-139]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0043228 (non-membrane-bounded organelle), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009534 (chloroplast thylakoid), GO:0009579 (thylakoid)
Protein: Nuclear envelope phosphatase-regulatory subunit 1 homolog (NEP1-R1) (Transmembrane protein 188) (Q9XXN3)
Organism: Caenorhabditis elegans
Function: May form with the serine/threonine protein phosphatase scpl-2 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May play a role in nuclear membrane dynamics being crucial for early development of the embryo.
Subcellular location: Nucleus membrane {ECO:0000250|UniProtKB:Q8N9A8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N9A8}. Cytoplasm {ECO:0000250|UniProtKB:Q8N9A8}.
Sequence: MAIQARRMPEDPSTACEDLKFFEKRLTEVITYMGPTCTRWRIAIVIFAVLVGVIGSKYFANEKIEIFQIPMIDMFLTTHLDFTLCFFVGLLLFAVFGVHRRIVAPTIVARRCRDALSPFSLSCDHNGKLIVKPAVRNSAP
InterPro domains: - IPR019168: Nuclear envelope phosphatase-regulatory subunit 1 (family) [11-138]
Interaction partners: - CTD nuclear envelope phosphatase 1 homolog
- Phenylalanine-4-hydroxylase
- LNS2/PITP domain-containing protein
- Torsin
- Torsin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0033043 (regulation of organelle organization), GO:0051783 (regulation of nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Ran GTPase-activating protein (RanGAP) (Protein segregation distorter) (Q9VIW3)
Organism: Drosophila melanogaster (Fruit fly)
Function: GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17032737}. Nucleus membrane {ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:31626769}; Peripheral membrane protein {ECO:0000269|PubMed:17032737}; Cytoplasmic side {ECO:0000269|PubMed:17032737}. Note=Association to cytoplasmic side of the nuclear pore complex is promoted by Nup214 (PubMed:17032737). Co-localizes with Nup358/RanBP2 to annulate lamellae (PubMed:31626769). {ECO:0000269|PubMed:17032737, ECO:0000269|PubMed:31626769}.
Sequence: MSTFNFASMAAQLGQEQGISFENKVLSWNTAADVQDVVDALNKQTTVHYLNLDGNTLGVEAAKAIGEGLKRHPEFRKALWKNMFTGRLISEIPEALKHLGAALIVAGAKLTVLDLSDNALGPNGMRGLEELLRSPVCYSLQELLLCNCGLGPEGGSMLSRALIDLHANANKAGFPLQLRVFIGSRNRLEDAGATEMATAFQTLKTFEEIVLEQNSIYIEGVEALAESFKHNPHLRVLNMNDNTLKSEGAEKIAEALPFLPLLREMSFGDCLIKTNGAYHFGEALERGNERLEVIDLGFNEINSDGGLVLVNAMGNKPKLRILNLDGNSFGEEGSEKIISEMSKLPTAAALQPFQHQEEEDLEDEYQADKQDADYEEEEEVHEHANDTTEEADEDSEGDEDDEEDEGDEEYSNVAEETAYVTTNAYTTKLFNDTTNSMASETFAVANKTISQKCTPEKFCLSQKPCSQEDFDSLDMDNKLEALQSIVNQFTGDNHLLLLVFTTLKCAHLSQSSKAALDLAVSLYQATFDYAIKTKQETRVLNYVLMQLRLLPCKEVFHSDYDVKNCRFALREALKQPTFANDNIKNSFKTFLEGAES
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [18-362]
- IPR001611: Leucine-rich repeat (repeat) [45-309]
- IPR027038: Ran GTPase-activating protein (family) [14-472]
- IPR036720: Ran-GTPase activating protein 1, C-terminal domain superfamily (homologous_superfamily) [419-596]
Interaction partners: - E3 SUMO-protein ligase RanBP2
- Dorsal interacting protein 4
- GTP-binding nuclear protein Ran
- Regulator of chromosome condensation
- Small ubiquitin-related modifier
- Exportin-1
- GTP-binding nuclear protein Ran-like
- FI04457p
- Nuclear pore complex protein Nup107
- NTF2-related export protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0003012 (muscle system process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) (P04916)
Organism: Rattus norvegicus (Rat)
Function: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:4708098}.
Sequence: MEWVWALVLLAALGGGSAERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGHMSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCADSYSFVFSRDPNGLTPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL
InterPro domains: - IPR012674: Calycin (homologous_superfamily) [19-201]
- IPR002449: Retinol binding protein/Purpurin (family) [1-201]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [39-162]
- IPR022272: Lipocalin family conserved site (conserved_site) [32-45]
- IPR022271: Lipocalin, ApoD type (family) [1-199]
Interaction partners: - Transthyretin
- Receptor for retinol uptake STRA6
- 30 kDa adipocyte complement-related protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0005515 (protein binding), GO:0008289 (lipid binding), GO:0019842 (vitamin binding), GO:0043178 (alcohol binding), GO:0019840 (isoprenoid binding), GO:0005501 (retinoid binding), GO:0019841 (retinol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0044706 (multi-multicellular organism process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0044703 (multi-organism reproductive process), GO:1901700 (response to oxygen-containing compound), GO:0007565 (female pregnancy), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0014070 (response to organic cyclic compound), GO:1901654 (response to ketone), GO:0033993 (response to lipid), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Cathepsin S (EC 3.4.22.27) (O70370)
Organism: Mus musculus (Mouse)
Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Subcellular location: Lysosome {ECO:0000250|UniProtKB:P25774}. Secreted {ECO:0000250|UniProtKB:P25774}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P25774}.
Sequence: MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
InterPro domains: - IPR013128: Peptidase C1A (family) [28-333]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [302-321]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [141-152]
- IPR039417: Papain-like cysteine endopeptidase (domain) [124-338]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [123-339]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [29-338]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [285-295]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [36-96]
Interaction partners: - H-2 class II histocompatibility antigen gamma chain
- Interleukin-10 receptor subunit alpha
- BH3-interacting domain death agonist
- Myeloperoxidase
- Cathepsin B
- Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Cyclic AMP-responsive element-binding protein 1
- Interleukin-10 receptor subunit beta
- Procathepsin L
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004180 (carboxypeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)