wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Plasmodium RESA N-terminal domain-containing protein (Q8IFM0)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MKFFNGSSFSNSNGFMDSKNLKNSAIFSFDEEEKKTASRSFLSSLLSKRMVIPMLGVLYVVLLNVCLHNGSNTSTNVQFNNNVGKRILSEGQSTDEYSESSSEYVENPVIGSTFMLPNENRLNTIGNLFEGEKYNILEDTQKLIDDINKFRYNSNYSPIPYPEQYNPVDYNKADFVLDKYIDNLGYCKGDTIKAMEIIWEATMNNERRKYAATKRSMLRYYDDLKRKRIIRPKTYTNKLNSCNQIMESSEKKIESHLSEMFNKWFKQKSLFLDDFNRFITACRIGWKTVSNAVQHQCDTIMRSKNFIDI
InterPro domains: - IPR044885: Plasmodium RESA, N-terminal helical domain superfamily (homologous_superfamily) [176-307]
- IPR019111: Plasmodium RESA, N-terminal (domain) [174-297]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell), GO:0020035 (adhesion of symbiont to microvasculature)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell)
Protein: V-set and immunoglobulin domain-containing protein 1 (Cell surface A33 antigen) (Glycoprotein A34) (Q86XK7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MVFAFWKVFLILSCLAGQVSVVQVTIPDGFVNVTVGSNVTLICIYTTTVASREQLSIQWSFFHKKEMEPISIYFSQGGQAVAIGQFKDRITGSNDPGNASITISHMQPADSGIYICDVNNPPDFLGQNQGILNVSVLVKPSKPLCSVQGRPETGHTISLSCLSALGTPSPVYYWHKLEGRDIVPVKENFNPTTGILVIGNLTNFEQGYYQCTAINRLGNSSCEIDLTSSHPEVGIIVGALIGSLVGAAIIISVVCFARNKAKAKAKERNSKTIAELEPMTKINPRGESEAMPREDATQLEVTLPSSIHETGPDTIQEPDYEPKPTQEPAPEPAPGSEPMAVPDLDIELELEPETQSELEPEPEPEPESEPGVVVEPLSEDEKGVVKA
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [31-134]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [23-231]
- IPR029861: V-set and immunoglobulin domain-containing protein 1 (family) [1-341]
- IPR000920: Myelin P0 protein-related (family) [35-139]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [18-232]
- IPR007110: Immunoglobulin-like domain (domain) [36-227]
- IPR003598: Immunoglobulin subtype 2 (domain) [34-218]
- IPR003599: Immunoglobulin domain subtype (domain) [28-229]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0098631 (cell adhesion mediator activity), GO:0030165 (PDZ domain binding), GO:0098632 (cell-cell adhesion mediator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0007155 (cell adhesion), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0098609 (cell-cell adhesion), GO:0048731 (system development), GO:0007158 (neuron cell-cell adhesion), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)
Protein: Small ribosomal subunit protein eS1 (40S ribosomal protein S1) (Q5AS60)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122}.
Sequence: MAVGKNKRLSKGKKGIKKRTVDPFTRKDEYSVKAPSTFANRDVGKTLVNRTSGLKNANDSLKGRIFEVSLADLQGDEDHAFRKVKLRVDEIQGKNCLTNFHGLDFTTDKLRSLVRKWQSLIEANVTVKTTDDYLLRLFAIAFTKRRPNQIKKTTYARSSQIRAIRKKMTEIMQREASSCSLAQLTSKLIPEVIGREIEKATQGIYPLQHVHIRKVKLLKSPKFDLGALLNLHGESTTDDKGQKVEREFKEQVLESV
InterPro domains: - IPR027500: Small ribosomal subunit protein eS1, eukaryotes (family) [1-256]
- IPR001593: Small ribosomal subunit protein eS1 (family) [15-221]
- IPR018281: Small ribosomal subunit protein eS1, conserved site (conserved_site) [61-73]
Interaction partners: - Large ribosomal subunit protein uL15
- 40S ribosomal protein S10a
- 40S ribosomal protein S17, putative
- Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein
- 40S ribosomal protein S27
- Small ribosomal subunit protein uS7 domain-containing protein
- Ribosomal protein L19
- 40S ribosomal protein S16
- 40S ribosomal protein S30
- 40S ribosomal protein S3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0030490 (maturation of SSU-rRNA), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process), GO:0000462 (maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA))
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Protein interacting with Ttk69 and Sin3A, isoform C (Q9VYL7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MSLQTKRQHCYLCDLPRMPWAMINDFSEAVCRGCVNYEGADRIEAVLDAARQMKRLHPASKQQRSHENGEVSAAAAAAVVLQQQQQLQVGPVPGQGPGSHRGGGGGGPPGAPPGSGGPGPSGAGSLSSLGNAVAAAAAAAAVHHHHQMPYQMPVPRIGPPLDYPVKLEDAPGGGVRPVRISHMTPHHLPPNATRGGGGAPGGGVPTAGSGGGSLPPALSVNLKRPPSEDVDVDVSQQQQQSGHGLAPDGSAGNSLSAGGGVSGGCPPGIKRSAMDDPSGVGGRPPLTRGESLPAAVSYVPERQLSGLRDKQQPVRAPSFDASTFKAEHMSPASRRNGSSPPSGPLPPRSVHSPNSSGSSSGRRSSGSRHVSSTTVTSSEVGGSNPGQAVVAGGLGGGGGGGPGSNAASGQLGGPSGGSGQLSCTSGGPGGSASSGSGGNGAIGPASMAPNSVAGDGSPAGGNGPSGSNGSGGSVNPGPGSSGSQGGGGGGTPLASGGGSAGSGGLGGAPGSSAASNSAAAAAAAAAQNATLKCTLCQERLEDTHFVQCPSVNHHKFCFPCSRESIKRQNGLGNEVYCPSGDRCPLANSVIPWAFMQGEITTILGEEVKVKKERES
InterPro domains: - IPR044882: Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily (homologous_superfamily) [545-604]
- IPR022750: Interferon regulatory factor 2-binding protein 1/2-like, zinc finger (domain) [6-57]
- IPR057414: Interferon regulatory factor 2-binding protein 1/2-like, C3HC4 zinc finger domain (domain) [531-603]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034399 (nuclear periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0005700 (polytene chromosome)
Protein: Regulator of microtubule dynamics protein 3 (RMD-3) (mRMD-3) (Protein FAM82A2) (Protein FAM82C) (Q3UJU9)
Organism: Mus musculus (Mouse)
Function: Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96TC7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q96TC7}. Cytoplasm {ECO:0000250|UniProtKB:Q96TC7}. Nucleus {ECO:0000250|UniProtKB:Q96TC7}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q96TC7}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q96TC7}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. {ECO:0000250|UniProtKB:Q96TC7}.
Sequence: MSRLGALGGSRAGLGLLLGTAAGLGFLCVLYSQRWKRTQRHGRSHSLPNSLDYAQASERGRQVTQFRAIPGEAGDAAILPSLSQEGQEKVLDRLDFVLTSLMALRREVEELQRSLQGLAGEIVGEVRSHIEENQRVARRRRFPFARERSDSTGSSSVYFTASSGAALTDAESEGGYTTANAESDYERDSDKESGDAEDEVSCETVRMGRKDSLDLDVEAASSPAAAALEEDDSSGREDVQLVLLQADELHQGSKQDKREGFQLLLNNKLAYGSRQDFLWRLARAYSDMSDLTEEESGKKSYALNGKEEAEAALKKGDESAACHLWYAVLCGQLAEHEGISKRIQSGFSFKEHVDKAIELQPEDPRGHFLLGRWCYQVSHLNWLEKKTATALFESPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARKWMKLAQELPDVTNEDSAFQKDLEELEVILG
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [252-452]
- IPR049039: Regulator of microtubule dynamics protein 1-3, alpha helical repeats (repeat) [237-469]
Interaction partners: - Vesicle-associated membrane protein-associated protein B
- Oxysterol-binding protein-related protein 5
- Oxysterol-binding protein-related protein 8
- Mitofusin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Smtnl protein (Q5BL23)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MDAGPLASVAEGSPEGETVCAALARYETTLRDAVREIHVDVSAFKLGIERRLEEAIHVSGPLGRAVAQLQQENRQLRGQLEALTRQVEMLTGSVCDRSALLTGGSQSSNSTGHQSPPSAAPSVAALTGSASGSASSPTTTRFSSRATFSVTSKTNSIERDEPIEVDPAPISQGLENGHLSSTENSIVPLRRNSPPNGVLHENSAPVPMAMPHLPITATTKVADSTVMKSPESPSSPMQATPSAITDSLTNSPPVTSDNQPQLESPVHAVSSVKTWAPTPARTMGSPRLTEKASSAPAKSVTYSGLFPHNTDRNVDTPGDLSFGRGIERRRELVRSQTLPRNIGAQARRSIFERLDSENNSRPKPVDSKPKLKRSQSFGVSSASSIKQILLEWCRSKTIGYQNIDIQNFSSSWSDGMAFCALVHSFFPTEFDYNGLSPAERKHNFELAFSTAEKKAGCDRLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRKFE
InterPro domains: - IPR001715: Calponin homology domain (domain) [383-490]
- IPR036872: CH domain superfamily (homologous_superfamily) [373-493]
- IPR050540: F-actin Monooxygenase Mical (family) [245-490]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: ERAD-associated E3 ubiquitin-protein ligase HRD1A (AtHrd1A) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase HRD1A) (Q9LW77)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD). Targets the misfolded LRR receptor kinase BRI1. Functions redundantly with HRD3B.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MIRLRTYAGLSFMATLAVIYHAFSSRGQFYPATVYLSTSKISLVLLLNMCLVLMLSLWHLVKFVFLGSLREAEVERLNEQAWRELMEILFAITIFRQDFSSGFLPLVVTLLLIKALHWLAQKRVEYIETTPSVSKLSHFRIVSFMGFLLLVDSLFMYSSIRHLIQSRQASVSLFFSFEYMILATTTVAIFVKYVFYVTDMLMDGQWEKKPVYTFYLELIRDLLHLSMYICFFFVIFMNYGVPLHLLRELYETFRNFQIRVSDYLRYRKITSNMNDRFPDATPEELTASDATCIICREEMTNAKKLICGHLFHVHCLRSWLERQQTCPTCRALVVPPENATSAAPGQRELHQGSQQGTSSSGNQGSEISSSAGVSNNSLSRHHARLQAAASAASVYGKSMVYPSANTVAWSSGVPGTEQVSTEPDQTLPQHNLPVENSHAYANMSETKLEEMRKSLETHLEILRNRLHFLETRKPESAGEPENKGKSVADAAE
InterPro domains: - IPR050731: HRD1 family E3 ubiquitin-protein ligases (family) [1-433]
- IPR058051: Synoviolin-like, RING finger (domain) [289-330]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [264-338]
- IPR057992: E3 ubiquitin-protein ligase synoviolin-like, TPR repeats (domain) [3-272]
- IPR001841: Zinc finger, RING-type (domain) [291-330]
Interaction partners: - Protein OS-9 homolog
- ERAD-associated E3 ubiquitin-protein ligase component HRD3A
- Derlin-1
- Ubiquitin-conjugating enzyme E2 32
- Derlin-2.1
- ERAD-associated E3 ubiquitin-protein ligase HRD1B
- Derlin-2.2
- Probable E3 ubiquitin ligase SUD1
- ERAD-associated E3 ubiquitin-protein ligase component HRD3B
- Peptide-N
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0035265 (organ growth), GO:0050794 (regulation of cellular process), GO:0010941 (regulation of cell death), GO:0048229 (gametophyte development), GO:0043067 (regulation of programmed cell death), GO:0009555 (pollen development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: At2g01710/T8O11.12 (Chaperone DnaJ-domain superfamily protein) (Expressed protein) (Q9ZU99)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MGDNNPNRSEAERLLGIAEKLLESRDLNGSKEFAILAQETEPLLEGTDQILAVVDVLLSSAPENRIKNQPNWYKILQIEDLTESSTDNDLIKKQYRRLALLLHPDKNRFPFADQAFRFVLDAWEVLSTPTKKSQFDGDLNLIFTKVNLNTQKSKKKTTTNEKMSTFWTACPYCYSLHEYPRVYQEYCIRCQNCQRAFHAASIPQLPPLIPGKDEYYCCWGFFPMGFVGGKGGEAAIANGVDAAKFPNWMPPVFSSGGVAAPPSGNGVSFDGWSGGAAKRDNEAVRSNNGVGVNSDGTPKKRGRGRPKKNPV
InterPro domains: - IPR001623: DnaJ domain (domain) [70-139]
- IPR053052: Imprinting Balance Regulator (family) [1-308]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [59-165]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Trehalose-phosphatase (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase) (TPP) (A8NS89)
Organism: Brugia malayi (Filarial nematode worm)
Function: Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.
Sequence: MTETVTDQGKQRSSKLQKNEAAKDEQVEGKGKETLESGTDKSAEQNSSLLVGQPDVIDNDNVQTVDDFKNLMYKMQETRRAIVFALLNEKDLTKDDVEILKRAYEKLTDNQTHSFQREMCTLTTKLSVNIGDETRGLEKDLKYLDALMNIRREEPNLLWPIIMSRVDLFSILANYHPKGKETFLKEYEDTVKFLKTFISSEAITGKKPIFITDWDGTMKDYCSQYATNLQPVYSAVGMTRFAASFTRISAVLTAGPLRGPGILDLTAMPIDGPVMFSGSWGREWWLSGKRVVHQDGITDEGFNALQRLDDEMKDLLHTSDYAPFALVGSGVQRKVDRLTLGVQTVCHHVTSELSNRYQMAVKERMHRVDPNSQILVFDPSTELEVEVVAHNSGIIWNKGNGVERLIKSLGDSLQSPGKILICGDTLSDIPMVRQAVKQNPDGVLAIFVGAKMSLREEVKQVIGDESRCCFVSCPDVIHAAMSQILNEHCIGK
InterPro domains: - IPR049063: Trehalose-6-phosphate phosphatase, C-terminal domain (domain) [210-477]
- IPR041064: Trehalose-6-phosphate phosphatase, helical bundle domain (domain) [64-159]
- IPR023214: HAD superfamily (homologous_superfamily) [210-483]
- IPR036412: HAD-like superfamily (homologous_superfamily) [208-450]
Interaction partners: - DnaJ homolog subfamily C member 10
- GrpE protein homolog
- Bm5434.
- Heat shock protein 90
- BMA-DNJ-15
- 10 kDa heat shock protein, mitochondrial
- Uncharacterized protein.
- BMA-DNJ-12
- Bm12893
- BMA-HSP-110
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0004805 (trehalose-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0009311 (oligosaccharide metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0005984 (disaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0005991 (trehalose metabolic process), GO:0016311 (dephosphorylation), GO:0009312 (oligosaccharide biosynthetic process), GO:0046351 (disaccharide biosynthetic process), GO:0005992 (trehalose biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)