Protein: Golgi phosphoprotein 3 (Coat protein GPP34) (Q9CRA5)
Organism: Mus musculus (Mouse)
Function: Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis (By similarity).
Subcellular location: [Isoform 2]: Golgi apparatus.; SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:17629635}; Peripheral membrane protein {ECO:0000269|PubMed:17629635}; Cytoplasmic side {ECO:0000269|PubMed:17629635}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:17629635}; Peripheral membrane protein {ECO:0000269|PubMed:17629635}; Cytoplasmic side {ECO:0000269|PubMed:17629635}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17629635}. Cell membrane {ECO:0000250}. Endosome {ECO:0000250}. Note=Phosphatidylinositol 4-phosphate-binding and oligomerization participate in the recruitment onto Golgi membranes. {ECO:0000305}.
Sequence: MTSLTQRSSGLVQRRTEASRNAADKERAAGGGGGSGEDEAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGRLQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGETWNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQEAVLDKWVNDPHRMDKRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDPEVECLKANTNEVLWAVVAAFTK
InterPro domains: - IPR008628: Golgi phosphoprotein 3-like (family) [1-298]
- IPR038261: Golgi phosphoprotein 3-like domain superfamily (homologous_superfamily) [50-298]
Interaction partners: - Unconventional myosin-XVIIIa
- Phosphatidylinositol-3-phosphatase SAC1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0019899 (enzyme binding), GO:0035091 (phosphatidylinositol binding), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:0051020 (GTPase binding), GO:0070300 (phosphatidic acid binding), GO:0031267 (small GTPase binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding), GO:0010314 (phosphatidylinositol-5-phosphate binding), GO:0070273 (phosphatidylinositol-4-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0002237 (response to molecule of bacterial origin), GO:0010628 (positive regulation of gene expression), GO:1901701 (cellular response to oxygen-containing compound), GO:0010468 (regulation of gene expression), GO:0071222 (cellular response to lipopolysaccharide), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0005802 (trans-Golgi network)