Protein: Gastric inhibitory polypeptide (GIP) (Glucose-dependent insulinotropic polypeptide) (Incretin hormone) (P09681)
Organism: Homo sapiens (Human)
Function: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
Subcellular location: Secreted.
Sequence: MVATKTFALLLLSLFLAVGLGEKKEGHFSALPSLPVGSHAKVSSPQPRGPRYAEGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQREARALELASQANRKEEEAVEPQSSPAKNPSDEDLLRDLLIQELLACLLDQTNLCRLRSR
InterPro domains: - IPR000532: Glucagon/GIP/secretin/VIP (domain) [52-79]
- IPR039078: Gastric inhibitory polypeptide (family) [1-152]
Interaction partners: - Gastric inhibitory polypeptide receptor
- Glucagon-like peptide 1 receptor
- Pro-glucagon
- Dipeptidyl peptidase 4
- Glucose-dependent insulinotropic receptor
- Secretin
- Vasoactive intestinal polypeptide receptor 2
- Beta-1 adrenergic receptor
- Lutropin-choriogonadotropic hormone receptor
- Insulin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0001664 (G protein-coupled receptor binding), GO:0071855 (neuropeptide receptor binding), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0044706 (multi-multicellular organism process), GO:0044703 (multi-organism reproductive process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:1903530 (regulation of secretion by cell), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0007617 (mating behavior), GO:0046887 (positive regulation of hormone secretion), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0010817 (regulation of hormone levels), GO:0003013 (circulatory system process), GO:0046883 (regulation of hormone secretion), GO:0099536 (synaptic signaling), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0001541 (ovarian follicle development), GO:0007548 (sex differentiation), GO:1903532 (positive regulation of secretion by cell), GO:0061458 (reproductive system development), GO:0008015 (blood circulation), GO:0002793 (positive regulation of peptide secretion), GO:0008406 (gonad development), GO:0044060 (regulation of endocrine process), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0007600 (sensory perception), GO:0019932 (second-messenger-mediated signaling), GO:0010507 (negative regulation of autophagy), GO:0007399 (nervous system development), GO:0090087 (regulation of peptide transport), GO:0003073 (regulation of systemic arterial blood pressure), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:1902531 (regulation of intracellular signal transduction), GO:0045761 (regulation of adenylate cyclase activity), GO:0008585 (female gonad development), GO:0060124 (positive regulation of growth hormone secretion), GO:0031281 (positive regulation of cyclase activity), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0002791 (regulation of peptide secretion), GO:0043950 (positive regulation of cAMP-mediated signaling), GO:0060123 (regulation of growth hormone secretion), GO:0043949 (regulation of cAMP-mediated signaling), GO:0045762 (positive regulation of adenylate cyclase activity), GO:0007190 (activation of adenylate cyclase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)