Protein: G1/S-specific cyclin-D2 (Vin-1 proto-oncogene) (Q04827)
Organism: Rattus norvegicus (Rat)
Function: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P30279}. Cytoplasm {ECO:0000250|UniProtKB:P30279}. Nucleus membrane {ECO:0000250|UniProtKB:P30279}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250|UniProtKB:P30279}.
Sequence: MELLCCEVDPVRRAVPDRNLLEDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQKEKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVNALTCDALTELLTKITHTDVDCLKACQEQIEAVLLNSLQQFRQEQHNGSKSVEDPDQATTPTDVRDVDL
InterPro domains: - IPR048258: Cyclins, cyclin-box (conserved_site) [55-86]
- IPR004367: Cyclin, C-terminal domain (domain) [153-283]
- IPR013763: Cyclin-like domain (domain) [60-144]
- IPR039361: Cyclin (family) [48-243]
- IPR006671: Cyclin, N-terminal (domain) [25-150]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [19-253]
Interaction partners: - cyclin-dependent kinase
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase inhibitor 1B
- Cyclin-dependent kinase 2
- Cyclin-dependent kinase inhibitor 1C
- Cyclin-dependent kinase inhibitor 1
- Retinoblastoma-like protein 2
- Retinoblastoma-associated protein
- Cyclin-dependent kinase 4 inhibitor C
- Cyclin-dependent kinase 4 inhibitor B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0003006 (developmental process involved in reproduction), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048608 (reproductive structure development), GO:1901700 (response to oxygen-containing compound), GO:0045137 (development of primary sexual characteristics), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0051726 (regulation of cell cycle), GO:0009991 (response to extracellular stimulus), GO:0010035 (response to inorganic substance), GO:0042127 (regulation of cell population proliferation), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:1902074 (response to salt), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0031099 (regeneration), GO:0008284 (positive regulation of cell population proliferation), GO:0010038 (response to metal ion), GO:0061458 (reproductive system development), GO:0097305 (response to alcohol), GO:1901654 (response to ketone), GO:0032355 (response to estradiol), GO:0048732 (gland development), GO:0048545 (response to steroid hormone), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0043627 (response to estrogen), GO:0033273 (response to vitamin), GO:0061008 (hepaticobiliary system development), GO:0031100 (animal organ regeneration), GO:0051592 (response to calcium ion), GO:0033197 (response to vitamin E), GO:0010243 (response to organonitrogen compound), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0014070 (response to organic cyclic compound), GO:0010212 (response to ionizing radiation), GO:0045471 (response to ethanol), GO:0032026 (response to magnesium ion), GO:0031960 (response to corticosteroid), GO:0008584 (male gonad development), GO:0001889 (liver development), GO:0010039 (response to iron ion), GO:0010165 (response to X-ray), GO:0051412 (response to corticosterone), GO:0051385 (response to mineralocorticoid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)