Protein: A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (P97857)
Organism: Mus musculus (Mouse)
Function: Cleaves aggrecan, a cartilage proteoglycan, at the '1691-Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity (By similarity). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (By similarity).
Subcellular location: Secreted, extracellular space, extracellular matrix.
Sequence: MQPKVPLGSRKQKPCSDMGDVQRAARSRGSLSAHMLLLLLASITMLLCARGAHGRPTEEDEELVLPSLERAPGHDSTTTRLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPGSEAQHLDPTGDLAHCFYSGTVNGDPGSAAALSLCEGVRGAFYLQGEEFFIQPAPGVATERLAPAVPEEESSARPQFHILRRRRRGSGGAKCGVMDDETLPTSDSRPESQNTRNQWPVRDPTPQDAGKPSGPGSIRKKRFVSSPRYVETMLVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIRNSISLVVVKILVIYEEQKGPEVTSNAALTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQDLCGSHTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKHCASLNGVSGDSHLMASMLSSLDHSQPWSPCSAYMVTSFLDNGHGECLMDKPQNPIKLPSDLPGTLYDANRQCQFTFGEESKHCPDAASTCTTLWCTGTSGGLLVCQTKHFPWADGTSCGEGKWCVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCKLTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKMSGIVTSTRPGYHDIVTIPAGATNIEVKHRNQRGSRNNGSFLAIRAADGTYILNGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKFTYFMKKKTESFNAIPTFSEWVIEEWGECSKTCGSGWQRRVVQCRDINGHPASECAKEVKPASTRPCADLPCPHWQVGDWSPCSKTCGKGYKKRTLKCVSHDGGVLSNESCDPLKKPKHYIDFCTLTQCS
InterPro domains: - IPR045371: ADAMTS/ADAMTS-like, cysteine-rich domain 3 (domain) [637-725]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [259-468]
- IPR041645: ADAMTS, cysteine-rich domain 2 (domain) [479-547]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [254-474]
- IPR006586: ADAM, cysteine-rich domain (domain) [469-549]
- IPR013273: ADAMTS/ADAMTS-like (family) [569-725]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [560-968]
- IPR010294: ADAMTS/ADAMTS-like, Spacer 1 (domain) [728-843]
- IPR050439: ADAMTS and ADAMTS-like (family) [282-967]
- IPR002870: Peptidase M12B, propeptide (domain) [75-137]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [557-967]
- IPR013274: Peptidase M12B, ADAM-TS1 (family) [1-944]
Interaction partners: - Aggrecan core protein
- Fibulin-1
- Metalloproteinase inhibitor 3
- Versican core protein
- Metalloproteinase inhibitor 1
- Collagenase 3
- Cartilage oligomeric matrix protein
- Metalloproteinase inhibitor 2
- Stromelysin-1
- Fibronectin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006952 (defense response), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043207 (response to external biotic stimulus), GO:0043170 (macromolecule metabolic process), GO:0098542 (defense response to other organism), GO:0009617 (response to bacterium), GO:0006508 (proteolysis), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)