wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40) (Q99848)
Organism: Homo sapiens (Human)
Function: Required for the processing of the 27S pre-rRNA.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:19170763, ECO:0000269|PubMed:2879624}. Note=Associated with the nucleolus in an RNA-dependent manner.
Sequence: MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQKPLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTAHGRGLKRPGKKGSNKRPGKRTREKMKNRTH
InterPro domains: - IPR008610: Eukaryotic rRNA processing (family) [10-302]
Interaction partners: - Ribosome biogenesis protein BRX1 homolog
- pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3
- Ribosome production factor 2 homolog
- 60S ribosome subunit biogenesis protein NIP7 homolog
- Pescadillo homolog
- MKI67 FHA domain-interacting nucleolar phosphoprotein
- Protein MAK16 homolog
- Ribosome biogenesis protein WDR12
- WD repeat-containing protein 74
- Nucleolar complex protein 2 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042273 (ribosomal large subunit biogenesis), GO:0042254 (ribosome biogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005694 (chromosome), GO:0005634 (nucleus)
Protein: Probable inorganic carbon transporter subunit DabB (Q2G0W2)
Organism: Staphylococcus aureus (strain NCTC 8325 / PS 47)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_00862}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|HAMAP-Rule:MF_00862}. Membrane {ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU000320}.
Sequence: MLSFQLLFSLFVIALIIALISGLLFLAPVMPMRYIKLHLYILVMPVLFAVIGFFGIHGQHVLGPFKIDRLSWLLAGFVMALGFIIQKFSMRYLLGDHHYRHYFPLFTAITSFASLAWMSEDLRLMALCWGITLLCLTLLMNVNRFWKVPRESAKLSSMTFLCGWLAFVGAIVTIYIATGEWRVPQHIVHPTWSLLTNVLLVLAVMIPAAQFPFHRWLIESVTAPTPVSAIMHAGIVNAGGVILTRFAPIFDNGFALSLLLILSSISVLLGSGISLVQVDYKRQLVGSTMSQMGFMLVQCALGVYSAAIIHLILHGIFKATLFLQSGSIVKRFNIPKQASAKDAYGWIVMGRVLAIIVAFLFWMSSDRSAYEVLSALILGWSLLVSWNQMVAFSKGRMARLVGMILIAIVTFIYVITHNYFYAVLQNITTHATTPPTVSVIISVVILIFGSLLSIWVARHRYSKAFAVLYVWLVNLGEARSKAIESHPNYLKKYL
InterPro domains: - IPR003945: NADH-quinone oxidoreductase, chain 5-like (family) [7-459]
- IPR001750: NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain (domain) [119-392]
- IPR046396: Probable inorganic carbon transporter subunit DabB (family) [4-488]
Interaction partners: - Probable inorganic carbon transporter subunit DabA
- Na+-translocating membrane potential-generating system MpsC domain-containing protein
- Putative antiporter subunit mnhD2
- Na
- Type II NADH:quinone oxidoreductase
- Type II NADH:quinone oxidoreductase
- Putative antiporter subunit mnhC2
- Na
- Na
- Putative antiporter subunit mnhA2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0050664 (oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor), GO:0016175 (superoxide-generating NAD(P)H oxidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0010035 (response to inorganic substance), GO:0097501 (stress response to metal ion), GO:1990170 (stress response to cadmium ion), GO:0010038 (response to metal ion), GO:1990169 (stress response to copper ion), GO:0046688 (response to copper ion), GO:0046686 (response to cadmium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Altered inheritance rate of mitochondria protein 29 (P36154)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: May be involved in mitochondrial organization and biogenesis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11914276}.
Sequence: MNSTKRLKMSTTFHDYDLEEPLTSNARPLKNSVITIRVIKSFPYRNVKNIVLHDYDLADKTAKDLFNDVLNKIQNEGSFRPFRNVKFDTLKIYTHAHGSKTVNLVINFDHDDDWTLDIENDKKKLFEYGIENETEISLFNKEDYLRFKENPEEKW
InterPro domains: - IPR018794: Uncharacterised protein family UPF0538 (family) [29-155]
Interaction partners: - Protein PBDC1 homolog
- Protein HGH1
- Pyridoxal phosphate homeostasis protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0031970 (organelle envelope lumen), GO:0070013 (intracellular organelle lumen), GO:0005758 (mitochondrial intermembrane space)
Protein: Spindle assembly checkpoint protein SLDB (C8VP05)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MASNQFTITSPPTDAISALKFSPAPDSTRFVVSSWDKNVYVYDLRDENGAAGEGKLLQKFEHRAPVLDACFGATEDEIFTAGLDWDVKRIDIASASQTVLSSHDAGVRSVVYSKEYSMVISASWDNTLHVHRLAGDRSVTNTASIPLPSKPFSMSLTATKLVVGMASRALHIYDLKSLSLLTGQSEGGVAPAKVEVEPWQRRESSLKFMTRCVACMPDDAGYASSSIEGRVAVEWFDPSAESQARKYAFKCHRQTSDDVDVVYPVNSLAFHPIHGTFASGGGDGVVALWDGIAKRRIRQYQKYPSSVAAVAFSSNGKYLAIAISPGYEDGKDDLTDGTVRIYVRELGETEAKGKGAK
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [1-357]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [7-324]
- IPR001680: WD40 repeat (repeat) [3-290]
Interaction partners: - Uncharacterized protein
- Mitotic spindle checkpoint protein
- Anaphase-promoting complex subunit 4
- Protein bimA
- Cell division cycle protein Cdc20, putative
- Anaphase-promoting complex subunit 5
- Chromosome segregation protein Spc105, putative
- 20S cyclosome subunit
- C2H2 finger domain protein, putative
- 20S cyclosome subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006325 (chromatin organization), GO:0006996 (organelle organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0051276 (chromosome organization), GO:0032200 (telomere organization), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization), GO:0031509 (subtelomeric heterochromatin formation), GO:0140719 (constitutive heterochromatin formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Ephrin-A6 (Q98TZ1)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}.
Sequence: LLGLLLWAPLLWAPPPPVRGRRHGVYWNGSNPRFLQDDYSIQVSINDHLDIYCPHYSAPTPWAESFTLFMVDEEGYRGCSETPGAFKRWECNKPFAPFVPVRFSEKIQRFTPFSLGFEFRPGETYYYISVPTPGSAGRCLKLRVSVCCRASTPEPLTEVPNSQPRGRGGPEGDAGSPRDAAPIPQRSRTRLVALAVVAVLWV
InterPro domains: - IPR031328: Ephrin (family) [11-164]
- IPR001799: Ephrin receptor-binding domain (domain) [20-150]
- IPR008972: Cupredoxin (homologous_superfamily) [18-157]
- IPR034252: Ephrin-A ectodomain (domain) [21-147]
- IPR019765: Ephrin, conserved site (conserved_site) [102-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046875 (ephrin receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050793 (regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0045664 (regulation of neuron differentiation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048013 (ephrin receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (EC 2.1.1.201) (Ubiquinone biosynthesis methyltransferase COQ5) (Q9CXI0)
Organism: Mus musculus (Mouse)
Function: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Subcellular location: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03191}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03191}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03191}.
Sequence: MAAPRCCVLWRVCGRGWWRATGHCRLPGCHRSWPWATLGTRSLSQEKRAAETHFGFETVSEGEKGSKVYQVFENVAKKYDLMNDMMSLGIHRAWKDLLIRKMHPLPGTQLLDMAGGTGDIAFRFLSYVQAQHQRRQRRQLRTQQNLSWEEIAKKYQNEEDSLGGSLATVCDINREMLKVGKQKALDQGHTAGLAWVLGDAEELPFDDDSFDVYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFGQVNDPLISRLYDLYSFQVIPVIGEVIAGDWKSYQYLVESIRKFPNQEDFKDMIEDAGFQRVTYENLTTGIVAIHSGFKL
InterPro domains: - IPR023576: UbiE/COQ5 methyltransferase, conserved site (conserved_site) [79-248]
- IPR004033: UbiE/COQ5 methyltransferase (family) [59-326]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [66-327]
Interaction partners: - Ubiquinone biosynthesis protein COQ9
- NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Atypical kinase COQ8A, mitochondrial
- Atypical kinase COQ8B, mitochondrial
- All trans-polyprenyl-diphosphate synthase PDSS1
- All trans-polyprenyl-diphosphate synthase PDSS2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008169 (C-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044281 (small molecule metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:1901661 (quinone metabolic process), GO:0042181 (ketone biosynthetic process), GO:0006743 (ubiquinone metabolic process), GO:1901663 (quinone biosynthetic process), GO:0006744 (ubiquinone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Pentatricopeptide repeat-containing protein At4g01990, mitochondrial (Q93WC5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000305}.
Sequence: MMHSVSRLARRFCATLATATAEISGEAAASVPTKAKKHRSIYKKLSSLGTRGGGKMEETLNQFVMEGVPVKKHDLIRYAKDLRKFRQPQRALEIFEWMERKEIAFTGSDHAIRLNLIAKSKGLEAAETYFNSLDDSIKNQSTYGSLLNCYCVEKEEVKAKAHFENMVDLNHVSNSLPFNNLMAMYMGLGQPEKVPALVVAMKEKSITPCDITYSMWIQSCGSLKDLDGVEKVLDEMKAEGEGIFSWNTFANLAAIYIKVGLYGKAEEALKSLENNMNPDVRDCYHFLINLYTGIANASEVYRVWDLLKKRYPNVNNSSYLTMLRALSKLDDIDGVKKVFAEWESTCWTYDMRMANVAISSYLKQNMYEEAEAVFNGAMKKCKGQFSKARQLLMMHLLKNDQADLALKHFEAAVLDQDKNWTWSSELISSFFLHFEEAKDVDGAEEFCKTLTKWSPLSSETYTLLMKTYLAAGKACPDMKKRLEEQGILVDEEQECLLSKICP
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [44-485]
- IPR002885: Pentatricopeptide repeat (repeat) [141-375]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0006995 (cellular response to nitrogen starvation), GO:0043562 (cellular response to nitrogen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Divalent-cation tolerance protein CutA (C-type cytochrome biogenesis protein CycY) (P69488)
Organism: Escherichia coli (strain K12)
Function: Involved in resistance toward heavy metals.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:7623666}.
Sequence: MLDEKSSNTASVVVLCTAPDEATAQDLAAKVLAEKLAACATLIPGATSLYYWEGKLEQEYEVQMILKTTVSHQQALLECLKSHHPYQTPELLVLPVTHGDTDYLSWLNASLR
InterPro domains: - IPR015867: Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal (homologous_superfamily) [1-112]
- IPR004323: Divalent ion tolerance protein, CutA (family) [8-111]
- IPR011322: Nitrogen regulatory PII-like, alpha/beta (homologous_superfamily) [11-111]
- IPR023700: Divalent cation tolerance protein CutA, Enterobacteria (family) [6-112]
Interaction partners: - Thiol:disulfide interchange protein DsbD
- Tryptophan biosynthesis protein TrpCF
- Thiol:disulfide interchange protein DsbC
- Co-chaperonin GroES
- HTH-type transcriptional regulator YjdC
- PF03932 family protein CutC
- Chaperonin GroEL
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0070206 (protein trimerization), GO:0070207 (protein homotrimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Dual specificity protein phosphatase PPS1 (EC 3.1.3.16) (EC 3.1.3.48) (P38148)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle.
Sequence: MVLEVPSITPGELHDLMRLHQDAEWPECKKMFPWAHDISFGQPPDFPHSLAIVKSQSDANNSALLRNSLEVNDIFQSWKVRTSFHREGDTCETGNDSNGFQYPNNTKELLNLLKFQIRQLELQVDDVALENAATYCHNHSILPFLKVDPRGLSLELKRYSRNKVGSNTTLKRSGQDVWGRRGLFRRFDLQCAKMIEMVDNIVIYCSRTGGSTDMQTESAPACSHEGNCPNCTTLALLLQICLMFVQKGYVGSGGSLYKTNLFICTYQNFNTDIPQTLIGTPLLDNEFFKNNTPLNLCSSPSEIVCFNNVDKNMVLCEKLELNKLTSATRLEETGLICGNTTDWHNYQIIKKNNISLTHRFEENTSIVNLKSLNYDTDNPTTSISQLYNIPNTKEVWKLIIKCTSNSQMPSLTKIRTYLDLLLDDDASKSQEHLHLTFPASGSIGLGNLNIQSVEILLNVCYLIFQVSQVQELLTFMYCEDGYTETSLLLTAYIIFHFNIPLQDALLRIHPRPFFLFPSDLQILGHLQPVLREFSPQNGSNLKLYANALKFRDKSFQLHISSELFSSIFFMKIPLESNFVNLKGPLPSRILRHLYLGSLDHAQNPALLKSLGITHIVSVGEVVSWTLNKDKIAHPVRPHRAITMTNTNEVAGNTTCNKSRNRADTVVSDKQENGSNVVISENSGFQICQIENLDDNGKDPLFHQIDKVLDFISNSEATGGKVLVHCMVGVSRSATVCIAECMRYLQCDLASAYLFVRVRRLNVIIQPNLFFVYELFKWWKKHYNREKDKTMDWHIICRGIAEVNMKYT
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [570-788]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [705-770]
- IPR053239: Dual specificity protein-tyrosine phosphatase (family) [2-807]
- IPR020422: Dual specificity protein phosphatase domain (domain) [585-783]
- IPR047949: Dual specificity protein phosphatase PPS1, dual specificity phosphatase domain (domain) [580-779]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [723-733]
- IPR000340: Dual specificity phosphatase, catalytic domain (domain) [668-777]
Interaction partners: - Dual-specificity protein phosphatase SDP1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation), GO:0035335 (peptidyl-tyrosine dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)