Protein: DEAD-box ATP-dependent RNA helicase 40 (EC 3.6.4.13) (Q9SQV1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MATTEDTPASAGPRYAPEDPTLPQPWKGLIDGSTGILYYWNPETNVTQYERPSAPPPHSATTPKLAQIPVPSSGQGHQAQHEQAKPVGHVSQQHGFQQQPQQFPSQHVRPQMMQQHPAQQMPQQSGQQFPQQQSQSMVPHPHGHPSVQTYQPTTQQQQQGMQNQHSQMPQQLSHQYAHSQQHYMGFRPHMQTQGLQNSHQTPQGGPHGQQFPSQQEYNSLAPKREGDEFHGGKKTGFSQPHLPNSERSPSQNTHFEANAASQKTNANLAMAQKCNGPQANAAVTQFQQPGANLIHQQLGPRAPNQMDQTMLHQKSHVSPFQSNNTYENNLQSRPGNDSYVNMRMEVPVRGAQPLHPAAMPKDIRISGGPPTNADPAMGQTGHGTYGHAGPAFPNKSLVRPHFVTSPDVPHLSPVEIYRKQHEVTTTGENIPAPYITFESSGLPPEILRELLSAGFPSPTPIQAQTWPIALQSRDIVAIAKTGSGKTLGYLIPAFILLRHCRNDSRNGPTVLILAPTRELATQIQDEALRFGRSSRISCTCLYGGAPKGPQLKELERGADIVVATPGRLNDILEMKMIDFQQVSLLVLDEADRMLDMGFEPQIRKIVNEIPPRRQTLMYTATWPKEVRKIASDLLVNPVQVNIGRVDELAANKAITQYVEVVPQMEKERRLEQILRSQERGSKVIIFCSTKRLCDHLARSVGRHFGAVVIHGDKTQGERDWVLNQFRSGKSCVLIATDVAARGLDIKDIRVVINYDFPTGVEDYVHRIGRTGRAGATGVAFTFFTEQDWKYAPDLIKVLEGANQQVPPQVRDIAMRGGGGGGPGYSQDRRGMVNRFDSGGGGTRWDSGGGFGGRGGGFSGREGGFGGREGGFGGREGGFGGRGGRFGMRDDSFGRGGNRGRGFTGPDAGHMNVGGRGGFGRFGNNNNMESRGFGRGSGRGFGRGVGRFDNRRGRSRSRSPDLVRPRRRSSSYSRSRSRSGSYSRSRSRSRSWSRSRSRSPRHSRDRGGHNRSRSYSRSPSPVYERRDRAPRVSGFDIKPPVESVVNLDMNAAAAIENVVPTSLSERQGNGVVESEVEAALVRPVVDEEP
InterPro domains: - IPR001202: WW domain (domain) [20-54]
- IPR000629: ATP-dependent RNA helicase DEAD-box, conserved site (conserved_site) [586-594]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [459-628]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [435-463]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [411-815]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [454-657]
- IPR036020: WW domain superfamily (homologous_superfamily) [15-55]
- IPR001650: Helicase, C-terminal domain-like (domain) [666-813]
Interaction partners: - DNA mismatch repair protein MutS, type 2
- Pescadillo homolog
- Pumilio homolog 6, chloroplastic
- F18C1.18 protein
- Hypoxia-responsive family protein
- Protein phosphatase inhibitor 2
- TOM1-like protein 1
- Probable boron transporter 3
- F-box/LRR-repeat protein 15
- Probable rRNA-processing protein EBP2 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0004386 (helicase activity), GO:1901363 (heterocyclic compound binding), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0008186 (ATP-dependent activity, acting on RNA), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0003724 (RNA helicase activity), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0019222 (regulation of metabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0035196 (miRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)