Protein: Acetylcholine receptor subunit gamma (P02714)
Organism: Tetronarce californica (Pacific electric ray) (Torpedo californica)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Sequence: MVLTLLLIICLALEVRSENEEGRLIEKLLGDYDKRIIPAKTLDHIIDVTLKLTLTNLISLNEKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVAYYANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAEEGEAVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDTDFQEIIFFLIIQRKPLFYIINIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIGKYLIFVMFVSMLIVMNCVIVLNVSLRTPNTHSLSEKIKHLFLGFLPKYLGMQLEPSEETPEKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLYKDLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSIGTLAIFLTGHFNQVPEFPFPGDPRKYVP
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [236-494]
- IPR006201: Neurotransmitter-gated ion-channel (family) [25-364]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [19-236]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [145-159]
- IPR002394: Nicotinic acetylcholine receptor (family) [55-143]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [236-492]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [243-484]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [22-236]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007267 (cell-cell signaling), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0099536 (synaptic signaling), GO:0098926 (postsynaptic signal transduction), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:1902074 (response to salt), GO:0071417 (cellular response to organonitrogen compound), GO:1901699 (cellular response to nitrogen compound), GO:1905144 (response to acetylcholine), GO:0095500 (acetylcholine receptor signaling pathway), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:1902075 (cellular response to salt), GO:1905145 (cellular response to acetylcholine)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0005892 (acetylcholine-gated channel complex)