Protein: DDB1- and CUL4-associated factor 13 (Q9NV06)
Organism: Homo sapiens (Human)
Function: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition
Subcellular location: Nucleus, nucleolus. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component
Sequence: MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK
InterPro domains: - IPR051733: WD repeat-containing DCAF13/WDSOF1 (family) [1-444]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [12-353]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [40-391]
- IPR001680: WD40 repeat (repeat) [55-362]
- IPR019775: WD40 repeat, conserved site (conserved_site) [82-96]
- IPR007287: Sof1-like protein (domain) [354-440]
Interaction partners: - U3 small nucleolar RNA-interacting protein 2
- WD repeat-containing protein 36
- Transducin beta-like protein 3
- WD repeat-containing protein 43
- WD repeat-containing protein 3
- U3 small nucleolar RNA-associated protein 4 homolog
- Nucleolar complex protein 4 homolog
- Bystin
- KRR1 small subunit processome component homolog
- WD repeat-containing protein 46
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0016922 (nuclear receptor binding), GO:0030331 (nuclear estrogen receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0030054 (cell junction), GO:0140535 (intracellular protein-containing complex), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043233 (organelle lumen), GO:0000151 (ubiquitin ligase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0080008 (Cul4-RING E3 ubiquitin ligase complex), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0015630 (microtubule cytoskeleton)