Protein: Multiple epidermal growth factor-like domains protein 8 (A0A139WHC7)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MRPQIINFSLRGIVVCLFVLVGNASVDLVPCDKTRRVFTNSWGVITDGPVGSNYTQDSHCEWLIKANDSHKFITLSFRSMGTECSYDYVFVYDGDSFRSPLLGSFSGKTEPQKVIASSGYMLVLLYSDTNYVLDGFRAEFSITDCPNNCSNHGLCYEHSCVCESDWGGYDCSKKLCPEHCGAKARPQRGHCEEGLCVCKPGFSGQACSLYQRDNVGNKWHWLSHSEGGLQPRAAHTAVYIESTDSLYVFGGYNLNQILSNLEIYSFKNSTWRDENGQILPDKGLLNAINPSSVAKLIQHAGPDWEQKWGLNSPKSFFRNSLYAVVNDNATIFTRRRQRHSRIPEGHKPKARYGHAACAQENGFVIFGGKLENGSLANDLWFYDVHSRKWHQRALMSLLQPPPLTRHTLTRAGDVIYLFGGSTEDGEFSSRLFAITLQPDGSENWQEVRPRGGKELDVRVVAHSTVYHAPTNSLLVYGGIVAGVARFSKLSDRMFAFQLDDRHWTEIHYTREHLREKYVPRERAFHTANIFGNYLIVFGGYSHRHNKEEICYDNQMYLYHLGCHTWVNPEILGKTNDSRYPKHQGVFAHAATVRNGNTLLLVGGYHGNVNGDLLAYTVPPMIASRKGEPYDPESACIRHRNYGECSADPECGWCSADELCYGRTIGANCTTNLQTTRCPGVCPALGDCHSCLIHGHVHAGVQPLVSASHKLGLGECTWCVQNARCHHKDDNYGVCGLREDSPSQIPGWWGPKGTEVVEPEQCRELDRRPGLTFVKYHHPVNFTQPDHVAIINATTVDFNSPTSPMLRGDATAGGEMVARLVGSLCLPTDWQEMLNVCISYCSATLKISDNLVTNVSAENNECKSAKWPFNETSGKVSVDFESHKMVTLGSYNNLHQQSKMELQHKKDTDEQAKEKFMRRKWRLISLLLWYQLCDHVDNCGDGSDENNMTLCATKIKPCNVMTEYKCANKKCIDKAQVCDFADDCGDSSDELGCHHNNVCTVDNRGGCEHHCMNLTDGGYICACYSGFIISKENRKVCLDVDECATGLHHCSQICTNLNGSYTCSCHEKFRLSDGLSGVCKALNEDLTLLFANGPEIRSYNPKSNEENDVISEEKRIEAIDYNPNTQMVYWADSYDKTIKRSYMINAVDGKVKAGYAQDLNMKGNSKPTALAIDWVGDNLYWTETDRAGSKPKGKVMVAKTDGRYRRALVNVGLENPTSIVVDPQYGRMFWSDSGSAPKIEVSWMDGSKRRPLIIDGIRTPTGLAIDYAMDHALYWVDTKLNNIESIKYDGTNRKTILRGELLKHPISLDVFESDLYWITRDTGELVKQDKFGRGVPVIVQKDLLNPSGVFTFEYLEPYANGTCSQYKNCLYCLTDSQCGWCEANNECVSRHEDESLTCTTGDADWRYLTLQPSACSNCSNYISCESCVGSGLCQWSIEDAKCSRVVQKAEAAVSIDQCPTPCYKRPDCASCLDQKGRCVWCEATQQCFSFSVYTSEYQFGLCREWLDQAFPLVTAQDNSILPAPRAEEQCKSCSLHTNCSRCLSSLSCGWCYNGSNPMTGMCVQGDFNNPHVNCSEALGITDAKWAYAQCPDVDECGLGLHDCHPQAICTNTDGSFSCHCRKGYIGDGRTSCIRTCYNVCVHGRCQGEPDYACKCDLGWFGDDCSKNCGCNNHSACPEGEGICEECMDWSMGEFCEECKPGSYGNATTEQGCHQCECNGHGIKELGECDNVTGTCYCQDNTEGEHCERCKMNYYGDPRNGKQCYYQCEARGVLDESRGQGISSMQAYSAPWGGSPTRECLWIIKPDVDYGTPIIQLQINSSQLNVTCGENAVYVYDGLPELVDMGSQSALSAVFCTEEALPVSTVESRTGQLTVHYKQGLPGEGFSAMYKVLNCEDNCEPPRECVRGQCVCQEGLVGYNCEEVICPRNCTYAKQQGTCDKAYGRCICAPGWVGPSCDIRYDIIVKKFINYVGRNKFAVLF
InterPro domains: - IPR051221: Low-density lipoprotein receptor-related (family) [931-1482]
- IPR006652: Kelch repeat type 1 (repeat) [244-273]
- IPR056863: Laminin/attractin/netrin-like, EGF domain (domain) [1667-1762]
- IPR035914: Spermadhesin, CUB domain superfamily (homologous_superfamily) [28-1893]
- IPR000742: EGF-like domain (domain) [144-1956]
- IPR056737: Attractin/MKLN-like, beta-propeller domain (domain) [333-613]
- IPR002049: Laminin-type EGF domain (domain) [1667-1956]
- IPR016201: PSI domain (domain) [634-1590]
- IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [1085-1354]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [1038-1617]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [1608-1619]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [909-994]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [954-994]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [1038-1631]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [970-992]
- IPR001881: EGF-like calcium-binding domain (domain) [981-1632]
- IPR000859: CUB domain (domain) [31-1891]
- IPR015915: Kelch-type beta-propeller (homologous_superfamily) [195-638]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [1586-1716]
- IPR000033: LDLR class B repeat (repeat) [1107-1332]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)