Protein: Nitrogen permease regulator 2 homolog (O42857)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Post-transcriptional regulator of nitrogen permeases (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MEYSEEGWMDQADSFPPRLLAIFFALFDPLQGPIVACEAPAGSVTNVDGGKNCLLPFETISDYVIPKRELCNKTITVCTNHYQVIGHPISIIGSNYERNALIFNMCMIFHEEEDSACYIPLVKRLARNLEVLEKQIHYISDLNKRPVIFSVIEQILEDMNNFCECMIQLDDQNSINIKLFPVFPSPPTVKSFHVPILTAQLDLLMDKNWDMTVQKVYPFINGINSVQRIAELANVSYRSCQKCMEHFLYYGCLIIADIFQFHNIYAMTTNAPNLLQDPDFQRECTAYVSTNSSNAKNVTFATIFKLYCSLRQGLRVKDWMNENKEIFKGLDVRRLISFGTIKGLIYRVHKYPYLERRTMRNNLTEEEKKLLGLLDGKHHFDELCVTLKKSPKVVNEMIAGLGDACFIYV
InterPro domains: - IPR009348: Nitrogen permease regulator 2-like (family) [13-352]
Interaction partners: - Nitrogen permease regulator 3-like protein
- Uncharacterized WD repeat-containing protein C12G12.01c
- Vacuolar membrane-associated protein iml1
- Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05
- Nucleoporin seh1
- Uncharacterized WD repeat-containing protein C4F8.11
- GTP-binding protein gtr1
- Protein transport protein sec13
- GTP-binding protein gtr2
- Mitochondrial inner membrane protease subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:2000242 (negative regulation of reproductive process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051445 (regulation of meiotic cell cycle), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009966 (regulation of signal transduction), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0008092 (cytoskeletal protein binding), GO:0060184 (cell cycle switching), GO:0019236 (response to pheromone), GO:0071310 (cellular response to organic substance), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0023058 (adaptation of signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:0031669 (cellular response to nutrient levels), GO:1902531 (regulation of intracellular signal transduction), GO:0032006 (regulation of TOR signaling), GO:0032007 (negative regulation of TOR signaling), GO:0042149 (cellular response to glucose starvation), GO:1904262 (negative regulation of TORC1 signaling), GO:1903432 (regulation of TORC1 signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0035859 (Seh1-associated complex), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle)