Protein: ADP-ribosylation factor-like protein 1 (P61212)
Organism: Rattus norvegicus (Rat)
Function: GTP-binding protein. Can activate phospholipase D with very low efficiency (By similarity). Important for normal function of the Golgi apparatus.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12972563}; Peripheral membrane protein {ECO:0000269|PubMed:12972563}; Cytoplasmic side {ECO:0000269|PubMed:12972563}. Membrane {ECO:0000250|UniProtKB:P40616}; Lipid-anchor {ECO:0000250|UniProtKB:P40616}.
Sequence: MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTPSEMANALGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ
InterPro domains: - IPR006689: Small GTPase superfamily, ARF/SAR type (family) [3-177]
- IPR024156: Small GTPase superfamily, ARF type (family) [1-174]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [7-181]
- IPR005225: Small GTP-binding domain (domain) [16-171]
Interaction partners: - Golgin subfamily A member 4
- Arfaptin-2
- Ras-related protein Rab-6A
- Ras-related protein Rab-6B
- Brefeldin A-inhibited guanine nucleotide-exchange protein 1
- Golgin subfamily A member 1
- Brefeldin A-inhibited guanine nucleotide-exchange protein 2
- Short coiled-coil protein
- Conserved oligomeric Golgi complex subunit 6
- GRIP and coiled-coil domain-containing protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0036094 (small molecule binding), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0019904 (protein domain specific binding), GO:0032553 (ribonucleotide binding), GO:0008047 (enzyme activator activity), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0060229 (lipase activator activity), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0016004 (phospholipase activator activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0015031 (protein transport), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0030054 (cell junction), GO:0031984 (organelle subcompartment), GO:0098794 (postsynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0098791 (Golgi apparatus subcompartment), GO:0005794 (Golgi apparatus), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0014069 (postsynaptic density), GO:0005770 (late endosome), GO:0098978 (glutamatergic synapse), GO:0005802 (trans-Golgi network), GO:0005798 (Golgi-associated vesicle), GO:0030135 (coated vesicle), GO:0098984 (neuron to neuron synapse), GO:0005777 (peroxisome), GO:0031903 (microbody membrane), GO:0031982 (vesicle), GO:0000139 (Golgi membrane), GO:0032279 (asymmetric synapse), GO:0097708 (intracellular vesicle), GO:0005778 (peroxisomal membrane), GO:0030137 (COPI-coated vesicle)