Protein: Protein transport protein SEC23 (P15303)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC23 interacts with BET3 in order to target TRAPPI complex to COPII involved in internalization of plasma membrane proteins like the maltose transporter.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10720463, ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:12235121, ECO:0000269|PubMed:8548805, ECO:0000269|PubMed:9568718}; Peripheral membrane protein {ECO:0000269|PubMed:11086000, ECO:0000269|PubMed:8548805}; Cytoplasmic side {ECO:0000269|PubMed:8548805}. Cytoplasm {ECO:0000269|PubMed:8548805}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8548805}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Sequence: MDFETNEDINGVRFTWNVFPSTRSDANSNVVPVGCLYTPLKEYDELNVAPYNPVVCSGPHCKSILNPYCVIDPRNSSWSCPICNSRNHLPPQYTNLSQENMPLELQSTTIEYITNKPVTVPPIFFFVVDLTSETENLDSLKESIITSLSLLPPNALIGLITYGNVVQLHDLSSETIDRCNVFRGDREYQLEALTEMLTGQKPTGPGGAASHLPNAMNKVTPFSLNRFFLPLEQVEFKLNQLLENLSPDQWSVPAGHRPLRATGSALNIASLLLQGCYKNIPARIILFASGPGTVAPGLIVNSELKDPLRSHHDIDSDHAQHYKKACKFYNQIAQRVAANGHTVDIFAGCYDQIGMSEMKQLTDSTGGVLLLTDAFSTAIFKQSYLRLFAKDEEGYLKMAFNGNMAVKTSKDLKVQGLIGHASAVKKTDANNISESEIGIGATSTWKMASLSPYHSYAIFFEIANTAANSNPMMSAPGSADRPHLAYTQFITTYQHSSGTNRIRVTTVANQLLPFGTPAIAASFDQEAAAVLMARIAVHKAETDDGADVIRWLDRTLIKLCQKYADYNKDDPQSFRLAPNFSLYPQFTYYLRRSQFLSVFNNSPDETAFYRHIFTREDTTNSLIMIQPTLTSFSMEDDPQPVLLDSISVKPNTILLLDTFFFILIYHGEQIAQWRKAGYQDDPQYADFKALLEEPKLEAAELLVDRFPLPRFIDTEAGGSQARFLLSKLNPSDNYQDMARGGSTIVLTDDVSLQNFMTHLQQVAVSGQA
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [626-730]
- IPR036180: Gelsolin-like domain superfamily (homologous_superfamily) [627-764]
- IPR037364: Protein transport protein Sec23 (family) [3-764]
- IPR036174: Zinc finger, Sec23/Sec24-type superfamily (homologous_superfamily) [45-117]
- IPR006900: Sec23/Sec24, helical domain (domain) [524-622]
- IPR006895: Zinc finger, Sec23/Sec24-type (domain) [53-93]
- IPR037550: Sec23, C-terminal (domain) [616-736]
- IPR012990: Sec23/Sec24, beta-sandwich (domain) [399-510]
- IPR036175: Sec23/Sec24 helical domain superfamily (homologous_superfamily) [524-626]
- IPR006896: Sec23/Sec24, trunk domain (domain) [120-387]
- IPR007123: Gelsolin-like domain (domain) [637-724]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [120-398]
Interaction partners: - Protein transport protein SEC13
- SED5-binding protein 2
- Protein transport protein SEC31
- Small COPII coat GTPase SAR1
- Protein transport protein SEC24
- SED5-binding protein 3
- COPII coat assembly protein SEC16
- Protein transport protein SEC22
- Integral membrane protein SED5
- Protein transport protein BET1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0035459 (vesicle cargo loading), GO:0061024 (membrane organization), GO:0006900 (vesicle budding from membrane), GO:0090114 (COPII-coated vesicle budding), GO:0016050 (vesicle organization), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0070971 (endoplasmic reticulum exit site), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0048475 (coated membrane), GO:0030133 (transport vesicle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012507 (ER to Golgi transport vesicle membrane), GO:0030127 (COPII vesicle coat), GO:0030134 (COPII-coated ER to Golgi transport vesicle), GO:0097708 (intracellular vesicle), GO:0030662 (coated vesicle membrane)