Protein: Glycine receptor subunit beta (Q6DC22)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents
Subcellular location: Cell projection, dendrite. Cytoplasm. Postsynaptic cell membrane; Multi-pass membrane protein
Sequence: MKALKVIFMLLIICLWMEGGFTKEKSAKKGKKKGKQVYCPSQLSSEDLARVPANSTSNILNKLLITYDPRIRPNFKGIPVEDRVNIFINSFGSIQETTMDYRVNIFLRQRWNDPRLRLPQDFKSDSLTVDPKMFKCLWKPDLFFANEKSANFHDVTQENILLFIFRNGDVLISMRLSVTLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLQFMWQSGDPVQMDEIALPQFDIKQEDIEYGNCTKYYAGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGILSVLSLSSECTSLASELPKVSYVKAIDIWLIACLLFGFASLVEYAVVQVMLNSPKLLEAERAKIATKEKAEGKTPAKNTINGMGSTPIHVSTLQVTETRCKKVCTSKSDLRTNDFSIVGSLPRDFELSNFDCYGKPIEVGSAFSKSQAKNNKKPPPPKPVIPSAAKRIDLYARALFPFSFLFFNVIYWSVYL
InterPro domains: - IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [57-264]
- IPR047029: Glycine receptor subunit beta, transmembrane domain (domain) [267-493]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [182-196]
- IPR008060: Glycine receptor beta (family) [38-443]
- IPR006201: Neurotransmitter-gated ion-channel (family) [52-493]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [272-490]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [263-494]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [49-264]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [266-494]
Interaction partners: - Gephyrin
- Gephyrin
- Transporter
- G protein-coupled receptor, class C, group 5, member Bb
- Glycine receptor subunit alphaZ1
- Glycine receptor subunit alpha-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005253 (monoatomic anion channel activity), GO:0022836 (gated channel activity), GO:0005254 (chloride channel activity), GO:0099095 (ligand-gated monoatomic anion channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005237 (inhibitory extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity), GO:0016933 (extracellularly glycine-gated ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0098982 (GABA-ergic synapse), GO:0030425 (dendrite)