Protein: adenylate cyclase (A0A8M6Z3Y2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MSWINGFLVARVDDRKTAWGERNGKKSKRKVGSSLCNPRYMSCLRDVEAMEPPPQPPHAQATRSGGPGGGPGGGPGGTGNFGMRCGWQEDHYGKMGSGGEGVGLKSVDLGFEDGDVKGRKRDGLGGDGSSEDTASGTGSVTAADCWQRVVRVFQSKKFQSRKLERLYQRYFFRLNQSSLTMLMGVLVIVCGVMLTFHCIHGPPDVVYASVLSVAMALFLALMVVCNRNGFHQDYMWMVSYLVIGVLIIVQVFGVLMVAPRSASEGIWWSVFFIYIIYTLLPVRMRAAVLSGGVLSAIHLLTTWRINQDDEFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLNGDYEVEPGFGGERNAYLKENSIETFLVLGCSQKRKDEKAMMAKMQRTRTNSNEALVPRWVPDRSFSRTKDSKVFRQMGIDETSSKDNRGAQEALNPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTSSLEKKYAKKVDDRFGGYVACTLLVFCFISFIQIVVFPHTLVMLGIYISIFIILANILFICAIYSCVKLFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLVDCVAKQLNWSSEMVTPCIIHNMSRSVADGLSICPNNTPSCPFPEYFSYSVLLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVALFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRVTKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKYRQLEKIKTIGSTYMAASGLNDSTYDKEGRSHITALADYAMHLREQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFLNDGPPNS
InterPro domains: - IPR018297: Adenylyl cyclase class-4/guanylyl cyclase, conserved site (conserved_site) [510-1152]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [391-1198]
- IPR009398: Adenylate cyclase, conserved domain (domain) [610-697]
- IPR030672: Adenylate cyclase (family) [135-1199]
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [360-1197]
- IPR032628: Adenylate cyclase, N-terminal (domain) [101-395]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0004016 (adenylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0010033 (response to organic substance), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0097305 (response to alcohol), GO:0051246 (regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0045471 (response to ethanol), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)