Protein: Gamma-enolase (P09104)
Organism: Homo sapiens (Human)
Function: Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium- dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity)
Subcellular location: Cytoplasm. Cell membrane. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form
Sequence: MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
InterPro domains: - IPR029017: Enolase-like, N-terminal (homologous_superfamily) [1-138]
- IPR020811: Enolase, N-terminal (domain) [3-134]
- IPR000941: Enolase (family) [1-430]
- IPR036849: Enolase-like, C-terminal domain superfamily (homologous_superfamily) [128-434]
- IPR020810: Enolase, C-terminal TIM barrel domain (domain) [142-431]
- IPR020809: Enolase, conserved site (conserved_site) [340-353]
Interaction partners: - Phosphoglycerate mutase 1
- Pyruvate kinase PKM
- Probable phosphoglycerate mutase 4
- Pyruvate kinase PKLR
- Glucose-6-phosphate isomerase
- Phosphoglycerate mutase 2
- Bisphosphoglycerate mutase
- Phosphoglycerate kinase 1
- Triosephosphate isomerase
- Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006735 (NADH regeneration), GO:0045926 (negative regulation of growth), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0043207 (response to external biotic stimulus), GO:0060548 (negative regulation of cell death), GO:0080134 (regulation of response to stress), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0030308 (negative regulation of cell growth), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0061621 (canonical glycolysis), GO:1901575 (organic substance catabolic process), GO:0051128 (regulation of cellular component organization), GO:0009615 (response to virus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0001558 (regulation of cell growth), GO:0080135 (regulation of cellular response to stress), GO:0005996 (monosaccharide metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:1900038 (negative regulation of cellular response to hypoxia), GO:0062013 (positive regulation of small molecule metabolic process), GO:0045933 (positive regulation of muscle contraction), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0046365 (monosaccharide catabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043436 (oxoacid metabolic process), GO:0043067 (regulation of programmed cell death), GO:0090257 (regulation of muscle system process), GO:0072521 (purine-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0006140 (regulation of nucleotide metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0045981 (positive regulation of nucleotide metabolic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019318 (hexose metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0006757 (ATP generation from ADP), GO:0010628 (positive regulation of gene expression), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:0006796 (phosphate-containing compound metabolic process), GO:1902532 (negative regulation of intracellular signal transduction), GO:2001233 (regulation of apoptotic signaling pathway), GO:1900037 (regulation of cellular response to hypoxia), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0006006 (glucose metabolic process), GO:1900542 (regulation of purine nucleotide metabolic process), GO:0042981 (regulation of apoptotic process), GO:0030810 (positive regulation of nucleotide biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0030162 (regulation of proteolysis), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway), GO:0016310 (phosphorylation), GO:0009259 (ribonucleotide metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1900544 (positive regulation of purine nucleotide metabolic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:1903317 (regulation of protein maturation), GO:0006937 (regulation of muscle contraction), GO:0009141 (nucleoside triphosphate metabolic process), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0019320 (hexose catabolic process), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0043066 (negative regulation of apoptotic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0045862 (positive regulation of proteolysis), GO:0006163 (purine nucleotide metabolic process), GO:1903319 (positive regulation of protein maturation), GO:0030808 (regulation of nucleotide biosynthetic process), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0045892 (negative regulation of DNA-templated transcription), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0032787 (monocarboxylic acid metabolic process), GO:0006007 (glucose catabolic process), GO:1903506 (regulation of nucleic acid-templated transcription), GO:1903580 (positive regulation of ATP metabolic process), GO:0061615 (glycolytic process through fructose-6-phosphate), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1900371 (regulation of purine nucleotide biosynthetic process), GO:1900373 (positive regulation of purine nucleotide biosynthetic process), GO:1903578 (regulation of ATP metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0010954 (positive regulation of protein processing), GO:0070613 (regulation of protein processing), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0010755 (regulation of plasminogen activation), GO:2001171 (positive regulation of ATP biosynthetic process), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0061718 (glucose catabolic process to pyruvate), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0046031 (ADP metabolic process), GO:0006090 (pyruvate metabolic process), GO:0046034 (ATP metabolic process), GO:2001169 (regulation of ATP biosynthetic process), GO:0061620 (glycolytic process through glucose-6-phosphate), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)