Protein: Replication factor C subunit 2 (Activator 1 40 kDa subunit) (A1 40 kDa subunit) (Activator 1 subunit 2) (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (Q9WUK4)
Organism: Mus musculus (Mouse)
Function: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MEVQESGCDPSESGAQEPSPVPSKTAGHYELPWVEKYRPLKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQVLTRLMNVIEKEKVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGYINSENVFKVCDEPHPLLVKEMIQHCVDANIDEAYKILAHLWHLGYSPEDVIGNIFRVCKTFPMAEYLKLEFIKEIGYTHMKVAEGVNSLLQMAGLLARLCQKTMAPVAS
InterPro domains: - IPR003593: AAA+ ATPase domain (domain) [63-189]
- IPR050238: DNA Replication and Repair Clamp Loader Complex (family) [30-333]
- IPR003959: ATPase, AAA-type, core (domain) [67-184]
- IPR047854: Replication factor C, lid domain (domain) [188-250]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [25-251]
- IPR013748: Replication factor C, C-terminal (domain) [253-338]
- IPR008921: DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal (homologous_superfamily) [253-341]
Interaction partners: - Cell cycle checkpoint protein RAD17
- Replication factor C subunit 5
- Replication factor C subunit 4
- Replication factor C subunit 3
- Replication factor C subunit 1
- Chromosome transmission fidelity protein 18 homolog
- Proliferating cell nuclear antigen
- Sister chromatid cohesion protein DCC1
- Chromosome transmission fidelity protein 8 homolog
- ATPase family AAA domain-containing protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2000573 (positive regulation of DNA biosynthetic process), GO:0051347 (positive regulation of transferase activity), GO:0006275 (regulation of DNA replication), GO:2000278 (regulation of DNA biosynthetic process), GO:0090329 (regulation of DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)