Protein: E1 ubiquitin-activating enzyme (A0A8M2B975)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MSSSPLSKKRRVSGSETKTGSHCSSSNSVRTELSHTPANGMAKNGNDAEIDEGLYSRQLYVLGHDAMKRMQSSNVLISGLRGLGVEIAKNVILGGVKSVTLHDQGVAEWKDLSSQFYLREEDLGKNRADVSQPRLAELNSYVPVTSYTGTLTNEYLTKFQVVVLTNSSLDEQTRIGEFCHSNGIKLIVADTRGLFGQLFCDFGEEMIVFDTNGEQPLSAMISMITKDSAGVVTCLDEARHGFESGDYVTFTEVQGMTELNGCDPVEIKTLGPYTFSICDTSSFSDYVRGGIVTQVKMPKKIAFKSLSSSMAEPEFLLTDFAKFDRPGQLHVGFQALHAFEKKHSRLPKPWNQADADELMTLAEEVNAAQTGSAKQEELDQAVIKKLACVAAGDLAPVNAFIGGLAAQEVMKACTGKFMPIMQWLYFDALECLPEPEEVILTEEECAPRNCRYDGQIAVFGSKLQELLAKQRYFLVGAGAIGCELLKNFAMMGLASGEGEVIVTDMDTIEKSNLNRQFLFRPWDVTKMKSETAAAAVKQMNPSVRITGHQNRVGPDTEKVYDDDFFECLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFITESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENALQYLTDSKFMERTLKLPGAQPLEVVESVYKSLVTDRPRNWDDCVTWARNHWQCQYNNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLEFSTNNDLHMDYILAAANLYALSYGLPSCNDRSALTKLLQDIKVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKTLLPSLEASSQFKLCPIEFEKDDDTNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELLKIVQGHKKLESYKNGFMNLALPFFAFSEPIAAPKHKYYEIDWTLWDRFEVKGIQPNGEEMTLRQFLDYFKNEHKLEITMLSQGVSMLYSFFMPAAKLKERLELPMTEIVTKVSKKKLGKHVKALVFELCCNDDTEEDVEVPYVRYTIR
InterPro domains: - IPR045886: ThiF/MoeB/HesA family (family) [451-1022]
- IPR018075: Ubiquitin-activating enzyme E1 (family) [49-1057]
- IPR042302: Ubiquitin-activating enzyme E1, FCCH domain superfamily (homologous_superfamily) [215-295]
- IPR042449: Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1 (homologous_superfamily) [45-163]
- IPR038252: Ubiquitin-activating enzyme E1, C-terminal domain superfamily (homologous_superfamily) [957-1058]
- IPR000011: Ubiquitin/SUMO-activating enzyme E1-like (family) [76-725]
- IPR018965: Ubiquitin-activating enzyme E1, C-terminal (domain) [922-1053]
- IPR033127: Ubiquitin-activating enzyme E1, Cys active site (active_site) [630-638]
- IPR042063: Ubiquitin-activating enzyme E1, SCCH domain (homologous_superfamily) [623-891]
- IPR035985: Ubiquitin-activating enzyme-like (homologous_superfamily) [49-940]
- IPR000594: THIF-type NAD/FAD binding fold (domain) [452-946]
- IPR032418: Ubiquitin-activating enzyme E1, FCCH domain (domain) [227-296]
- IPR032420: Ubiquitin-activating enzyme E1, four-helix bundle (domain) [297-366]
- IPR019572: Ubiquitin-activating enzyme, SCCH domain (domain) [638-884]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0008641 (ubiquitin-like modifier activating enzyme activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016877 (ligase activity, forming carbon-sulfur bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0032990 (cell part morphogenesis), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)