Protein: BTB and MATH domain-containing protein 42 (P34371)
Organism: Caenorhabditis elegans
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Sequence: MSSRSSWSSTEQINRTISSRADDLPPQPRRLEVVSKQATRVTALSTKLEWKIEQFEKLMKLIKNGSNLISRMFSVPDAPTVCWELHVYPNGKRDEDVNNVSFFLRQVGLARGEEPIMTEFQIYALDANNQRVSVCRDTKDFTNQQGRGKFQVSRDKMLGALRSDGTLFLICEVEYFPPGSKISVEPVVDEDVSTEEQEEMPEVIVRANNRSMWEDELFTDCVIHVGNKHIKAHRCILGQNSPVFKSMFSSPNMIEAQKGEIHIEDAKYDSVRAMVEFMYTGATESLESQGNIDEILAIADKYEVLMLKDQCERLIAQTINLKNVTQIAMFSDTYTADYLKSAVIRFLTTHHRVVIKTQDWISLKKSRHELANELLEAVLSTDQDDDDVTSNIPISVSPPPARKRLRRSAK
InterPro domains: - IPR002083: MATH/TRAF domain (domain) [45-174]
- IPR008974: TRAF-like (homologous_superfamily) [44-176]
- IPR000210: BTB/POZ domain (domain) [212-319]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [189-319]
Interaction partners: - Inositol polyphosphate 5-phosphatase
- Cullin-3
- BTB domain-containing protein
- BTB domain-containing protein
- BTB domain-containing protein
- UBR-type domain-containing protein
- REPS homolog
- FLYWCH transcription factor 1
- Serine/threonine-protein kinase sel-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007163 (establishment or maintenance of cell polarity), GO:0048584 (positive regulation of response to stimulus), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0009791 (post-embryonic development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:1903046 (meiotic cell cycle process), GO:0007017 (microtubule-based process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0000910 (cytokinesis), GO:0010171 (body morphogenesis), GO:0090068 (positive regulation of cell cycle process), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0030010 (establishment of cell polarity), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0000226 (microtubule cytoskeleton organization), GO:0032886 (regulation of microtubule-based process), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0045165 (cell fate commitment), GO:0001709 (cell fate determination), GO:0010646 (regulation of cell communication), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0002164 (larval development), GO:0010647 (positive regulation of cell communication), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007338 (single fertilization), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:1901565 (organonitrogen compound catabolic process), GO:1901989 (positive regulation of cell cycle phase transition), GO:0030163 (protein catabolic process), GO:1905818 (regulation of chromosome separation), GO:1902532 (negative regulation of intracellular signal transduction), GO:1905820 (positive regulation of chromosome separation), GO:0045931 (positive regulation of mitotic cell cycle), GO:0051983 (regulation of chromosome segregation), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0090224 (regulation of spindle organization), GO:0051293 (establishment of spindle localization), GO:1901987 (regulation of cell cycle phase transition), GO:0033043 (regulation of organelle organization), GO:1902533 (positive regulation of intracellular signal transduction), GO:0046605 (regulation of centrosome cycle), GO:0006996 (organelle organization), GO:0010824 (regulation of centrosome duplication), GO:1902531 (regulation of intracellular signal transduction), GO:0009792 (embryo development ending in birth or egg hatching), GO:0090266 (regulation of mitotic cell cycle spindle assembly checkpoint), GO:0051783 (regulation of nuclear division), GO:0090266 (regulation of mitotic cell cycle spindle assembly checkpoint), GO:0051783 (regulation of nuclear division), GO:0010965 (regulation of mitotic sister chromatid separation), GO:1903504 (regulation of mitotic spindle checkpoint), GO:0033045 (regulation of sister chromatid segregation), GO:1902101 (positive regulation of metaphase/anaphase transition of cell cycle), GO:0048285 (organelle fission), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051276 (chromosome organization), GO:1902099 (regulation of metaphase/anaphase transition of cell cycle), GO:0007010 (cytoskeleton organization), GO:0033047 (regulation of mitotic sister chromatid segregation), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0000819 (sister chromatid segregation), GO:0051785 (positive regulation of nuclear division), GO:0033044 (regulation of chromosome organization), GO:1901976 (regulation of cell cycle checkpoint), GO:0090231 (regulation of spindle checkpoint), GO:0000280 (nuclear division), GO:0030071 (regulation of mitotic metaphase/anaphase transition), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0031463 (Cul3-RING ubiquitin ligase complex)