Protein: Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) [Cleaved into: Actin, aortic smooth muscle, intermediate form] (P62740)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Sequence: MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF
InterPro domains: - IPR020902: Actin/actin-like conserved site (conserved_site) [106-118]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [6-377]
- IPR004000: Actin family (family) [6-377]
- IPR004001: Actin, conserved site (conserved_site) [55-366]
Interaction partners: - Myosin-11
- Myosin light chain 9
- Myosin-10
- EF-hand domain-containing protein
- Actin gamma 2, smooth muscle
- Transgelin
- Uncharacterized protein
- Vimentin
- Platelet-derived growth factor receptor beta
- Collagen type I alpha 1 chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0098772 (molecular function regulator activity), GO:0140677 (molecular function activator activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0048306 (calcium-dependent protein binding), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0019904 (protein domain specific binding), GO:0008092 (cytoskeletal protein binding), GO:0046872 (metal ion binding), GO:0017022 (myosin binding), GO:0005523 (tropomyosin binding), GO:0003779 (actin binding), GO:0003785 (actin monomer binding), GO:0000287 (magnesium ion binding), GO:0005509 (calcium ion binding), GO:0032036 (myosin heavy chain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0008154 (actin polymerization or depolymerization), GO:0051017 (actin filament bundle assembly), GO:0061572 (actin filament bundle organization), GO:0051258 (protein polymerization), GO:0030041 (actin filament polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0031941 (filamentous actin), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032432 (actin filament bundle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005884 (actin filament), GO:0015629 (actin cytoskeleton)