Protein: Transmembrane channel-like protein 1 (Beethoven protein) (Deafness protein) (Transmembrane cochlear-expressed protein 1) (Q8R4P5)
Organism: Mus musculus (Mouse)
Function: Probable ion channel required for the normal function of cochlear hair cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25114259, ECO:0000269|PubMed:28534737}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia tips of the cochlear hair cells. {ECO:0000269|PubMed:28504928, ECO:0000269|PubMed:38228630}.
Sequence: MLQIQVEEKEEDTEESSSEEEEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLRRGAEEEEEIDEEELERLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMRNKKMAAARAAAAAGGQ
InterPro domains: - IPR038900: Transmembrane channel-like protein (family) [10-742]
- IPR012496: TMC domain (domain) [512-627]
Interaction partners: - LHFPL tetraspan subfamily member 5 protein
- Calcium and integrin-binding family member 2
- Transmembrane inner ear expressed protein
- Protocadherin-15
- Transmembrane channel-like protein 2
- Calcium and integrin-binding family member 3
- Cadherin-23
- Unconventional myosin-VIIa
- pre-mRNA splicing regulator USH1G
- Whirlin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0051606 (detection of stimulus), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0009581 (detection of external stimulus), GO:0051049 (regulation of transport), GO:0032410 (negative regulation of transporter activity), GO:0032409 (regulation of transporter activity), GO:0044092 (negative regulation of molecular function), GO:0043271 (negative regulation of monoatomic ion transport), GO:0034762 (regulation of transmembrane transport), GO:0009582 (detection of abiotic stimulus), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0050906 (detection of stimulus involved in sensory perception), GO:0034763 (negative regulation of transmembrane transport), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0032413 (negative regulation of ion transmembrane transporter activity), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:0007600 (sensory perception), GO:0050910 (detection of mechanical stimulus involved in sensory perception of sound), GO:1903170 (negative regulation of calcium ion transmembrane transport), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0050954 (sensory perception of mechanical stimulus), GO:1904063 (negative regulation of cation transmembrane transport), GO:0010959 (regulation of metal ion transport), GO:0007605 (sensory perception of sound), GO:1903169 (regulation of calcium ion transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)