wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q57TR5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Sequence: MSQLREEKSEKMRYSALHSCLWVMFLLLFHALNVDGNSKGAIQGAKWKPLCTLTADANKVYNRALKLQILITDYTKAATKLAVEAVAAAQKMQNAEAHAAAIGLVAEIREQLKSKQPEIARCYKVAVETPAFIGYTHGRIAEFLEIMGHNRGASNYGYLAQLSSPTSPATDAATAQLSSCKIKPHDITEGPEETEVLTKKGFVGMDHGTGLVDGVLTSSCNEHCVLTSATATALNSDTGPQEDIPFTNGYILKHQTNTARSSQLINSLSKQAKGLPNKGQNQQYVRLWDKYVQLEGCETSFKAGFSKPEAQTLKQSVAVLTALKNIIDNESGEYDLSKDGEQIKTVAEKLFKHGEDNYPEKLYKEAQAKTLRKTLMAGNTATSLTNLETPIDLQIAQMYYTQRKIDGFIAKLKEAEEQLSKDKLGDYGAAAAEHACNKLDGEQKCNTDKKCSYETASDGTNKCTYNASKAKANNVPVAPTQTESAKKTTKKCKGKKKDDCKSPDCKWEGETCKDFSFLVNTKSTLMAATFLSFFKIFHPLFPC
InterPro domains: - IPR019609: Trypanosome variant surface glycoprotein, C-terminal (domain) [436-533]
- IPR001812: Trypanosome variant surface glycoprotein, A-type, N-terminal domain (domain) [23-401]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: MYB transcription factor (Myb domain protein 69) (Putative transcription factor) (Q9SZC2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MEMSRGSNSFDNKKPSCQRGHWRPVEDDNLRQLVEQYGPKNWNFIAQHLYGRSGKSCRLRWYNQLDPNITKKPFTEEEEERLLKAHRIQGNRWASIARLFPGRTDNAVKNHFHVIMARRKRENFSSTATSTFNQTWHTVLSPSSSLTRLNRSHFGLWRYRKDKSCGLWPYSFVSPPTNGQFGSSSVSNVHHEIYLERRKSKELVDPQNYTFHAATPDHKMTSNEDGPSMGDDGEKNDVTFIDFLGVGLAS
InterPro domains: - IPR017930: Myb domain (domain) [14-120]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [17-112]
- IPR001005: SANT/Myb domain (domain) [14-118]
- IPR050560: Transcription factors Myb-like (family) [19-143]
Interaction partners: - NAC domain-containing protein 73
- NAC domain-containing protein 10
- NAC domain-containing protein 12
- Homeobox protein knotted-1-like 7
- NAC domain-containing protein 66
- NAC domain-containing protein 43
- NAC domain-containing protein 30
- NAC domain-containing protein 104
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Pregnancy-specific beta-1-glycoprotein 6 (PS-beta-G-6) (PSBG-6) (Pregnancy-specific glycoprotein 6) (Pregnancy-specific beta-1-glycoprotein 10) (PS-beta-G-10) (PSBG-10) (Pregnancy-specific glycoprotein 10) (Pregnancy-specific beta-1-glycoprotein 12) (PS-beta-G-12) (PSBG-12) (Pregnancy-specific glycoprotein 12) (Q00889)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000305}.
Sequence: MGPLSAPPCTQHITWKGLLLTASLLNFWNLPTTAQVIIEAKPPKVSEGKDVLLLVHNLPQNLTGYIWYKGQMTDLYHYITSYVVHGQIIYGPAYSGRETVYSNASLLIQNVTQEDAGSYTLHIIKRGDGTGGVTGYFTVTLYSETPKPSISSSNLNPREVMEAVRLICDPETPDASYLWLLNGQNLPMTHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLPMPYITINNLNPREKKDVLAFTCEPKSRNYTYIWWLNGQSLPVSPRVKRPIENRILILPSVTRNETGPYQCEIRDRYGGIRSNPVTLNVLYGPDLPRIYPSFTYYRSGENLDLSCFADSNPPAEYSWTINGKFQLSGQKLFIPQITTNHSGLYACSVRNSATGKEISKSMIVKVSETASPQVTYAGPNTWFQEILLL
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [40-130]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [35-422]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [35-420]
- IPR007110: Immunoglobulin-like domain (domain) [148-405]
- IPR003598: Immunoglobulin subtype 2 (domain) [159-400]
- IPR003599: Immunoglobulin domain subtype (domain) [40-413]
- IPR050831: Carcinoembryonic antigen-related cell adhesion (family) [1-235]
Interaction partners: - Pregnancy-specific beta-1-glycoprotein 1
- Pregnancy-specific beta-1-glycoprotein 3
- Chorionic somatomammotropin hormone 1
- Chorionic somatomammotropin hormone 2
- Pregnancy-specific beta-1-glycoprotein 9
- Pregnancy specific beta-1-glycoprotein 7
- Pregnancy-specific beta-1-glycoprotein 4
- Pregnancy-specific beta-1-glycoprotein 5
- Pregnancy-specific beta-1-glycoprotein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0044706 (multi-multicellular organism process), GO:0044703 (multi-organism reproductive process), GO:0007565 (female pregnancy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0043235 (receptor complex), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:1990234 (transferase complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0005886 (plasma membrane), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex)
Protein: N-acetylglucosamine-induced protein 1 (GlcNAc-Induced Gene) (Q59VM7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: N-acetylglucosamine-induced protein which plays a role in the N-acetylglucosamine metabolic pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:20675577}.
Sequence: MNPATIITNFNNSQLQTPPTSPVSFDKYYTYYNIQLEQSTLMPQPSKIKNGDPFTWSDIQFIIKSNQLEIFARSRQQTIKYHKFKQWLKDNKLSINDYLLDYELHWKESELREQQHELVSDKEYSIDYPEDLIFHNPNDISILYNKFPYYFEPNVKHICIWSKLKIPVDKNSEVGDISVMTKKLINRYLEKTFVAKGISWDQIVWFKNWLSLQSVRSISHIHVILKDVDDKFVDELISGGSGEVLTLDDYRNLE
InterPro domains: - IPR022036: Protein of unknown function DUF3605 (family) [8-236]
Interaction partners: - N-acetylglucosamine-6-phosphate deacetylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070569 (uridylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006518 (peptide metabolic process), GO:0043043 (peptide biosynthetic process), GO:0019184 (nonribosomal peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Naphthalene 1,2-dioxygenase system, large oxygenase component (EC 1.14.12.12) (ISP NAP) (Naphthalene 1,2-dioxygenase ISP alpha) (Naphthalene 1,2-dioxygenase subunit alpha) (ND subunit alpha) (NDO subunit alpha) (P0A110)
Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
Function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene. The alpha subunit has a catalytic role in the holoenzyme. Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene.
Sequence: MNYNNKILVSESGLSQKHLIHGDEELFQHELKTIFARNWLFLTHDSLIPAPGDYVTAKMGIDEVIVSRQNDGSIRAFLNVCRHRGKTLVSVEAGNAKGFVCSYHGWGFGSNGELQSVPFEKDLYGESLNKKCLGLKEVARVESFHGFIYGCFDQEAPPLMDYLGDAAWYLEPMFKHSGGLELVGPPGKVVIKANWKAPAENFVGDAYHVGWTHASSLRSGESIFSSLAGNAALPPEGAGLQMTSKYGSGMGVLWDGYSGVHSADLVPELMAFGGAKQERLNKEIGDVRARIYRSHLNCTVFPNNSMLTCSGVFKVWNPIDANTTEVWTYAIVEKDMPEDLKRRLADSVQRTFGPAGFWESDDNDNMETASQNGKKYQSRDSDLLSNLGFGEDVYGDAVYPGVVGKSAIGETSYRGFYRAYQAHVSSSNWAEFEHASSTWHTELTKTTDR
InterPro domains: - IPR017941: Rieske [2Fe-2S] iron-sulphur domain (domain) [38-123]
- IPR015879: Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain (domain) [160-425]
- IPR043266: Ring-hydroxylating dioxygenase, alpha subunit NdoB-like, C-terminal (domain) [179-425]
- IPR001663: Aromatic-ring-hydroxylating dioxygenase, alpha subunit (family) [22-369]
- IPR015881: Aromatic-ring-hydroxylating dioxygenase ARHD, Rieske 2Fe-2S-binding site (binding_site) [81-104]
- IPR036922: Rieske [2Fe-2S] iron-sulphur domain superfamily (homologous_superfamily) [12-164]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0051540 (metal cluster binding), GO:0043169 (cation binding), GO:0051536 (iron-sulfur cluster binding), GO:0051537 (2 iron, 2 sulfur cluster binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0120252 (hydrocarbon metabolic process), GO:0044248 (cellular catabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0019439 (aromatic compound catabolic process), GO:0120253 (hydrocarbon catabolic process), GO:1901361 (organic cyclic compound catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Q91X83)
Organism: Mus musculus (Mouse)
Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Sequence: MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSVAMVDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRIADLRRSGVLPWLRPDSKTQVTVQYMQDNGAVIPVRIHTIVISVQHNEDITLEAMQEALKEQVIKAVVPAKYLDEDTVYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSNKTERELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
InterPro domains: - IPR002133: S-adenosylmethionine synthetase (family) [13-396]
- IPR022631: S-adenosylmethionine synthetase, conserved site (conserved_site) [132-287]
- IPR022636: S-adenosylmethionine synthetase superfamily (homologous_superfamily) [19-393]
- IPR022628: S-adenosylmethionine synthetase, N-terminal (domain) [19-116]
- IPR022630: S-adenosylmethionine synthetase, C-terminal (domain) [253-389]
- IPR022629: S-adenosylmethionine synthetase, central domain (domain) [131-251]
Interaction partners: - Methionine adenosyltransferase 2 subunit beta
- Betaine--homocysteine S-methyltransferase 1
- S-adenosylmethionine synthase isoform type-2
- Methionine synthase
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- S-adenosylmethionine decarboxylase proenzyme 1
- S-adenosylmethionine decarboxylase proenzyme 2
- Tyrosine aminotransferase
- DNA
- DNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0046500 (S-adenosylmethionine metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0044272 (sulfur compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: F14O23.23 protein (Ubiquitin carboxyl-terminal hydrolase family protein) (Q9M9G1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MKSIFRSISIRRHSGHRTFADTSAVEDTYKFVRDRGLDHAVEREKNLRPLLSIKDLIRSEPAKSVPISVITSQKDSLRVPLRPIEFIRSFPSVFQEFLPGGIGIHPHISLTPEILNHDADEQLVYGSETYKQGLADRLLKLLMINRINKIPLEILDLLKWDLGLPKDYVETMVPEFPDYFRVIKSKLRGCSGELELVCWSNEHAVSVLEKKARTLRKGEYTKGSAIAFPMKFSNGFVVDKKMKKWIDDWQKLPYISPYENALHLSATSDESDKWAAAVLHEIMNLFVSKKVEKDAILHLGEFMGLRSRFKRVLHNHPGIFYLSSKLRTHTVVLRDGYKRGMLIESNELVTSRNRYMKLMNTVKKDNKAVSSSSKKEDKGKVEGEVCDTDAKAENDDISGSDVEDDRQGDFVDDDEDDDEVDQNQDLERGRRNSSPRSGRRSFGNSGSRDKAQSRRSKISLKTEKKRSRMY
InterPro domains: - IPR021099: Plant organelle RNA recognition domain (domain) [32-363]
- IPR045040: PORR family (family) [22-404]
Interaction partners: - Protein-tyrosine-phosphatase PTP1
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Plant invertase/pectin methylesterase inhibitor superfamily protein
- Senescence/dehydration-associated protein At4g35985
- Uncharacterized protein MHF15.4
- Calmodulin-lysine N-methyltransferase
- Peptide deformylase 1B, chloroplastic/mitochondrial
- Probable choline kinase 2
- Peptide deformylase 1A, chloroplastic/mitochondrial
- Probable LRR receptor-like serine/threonine-protein kinase At5g10290
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile), GO:0000373 (Group II intron splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: GH09628p (Q7K3V9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MVYPSDTSDANNEELALEHSVAHGNVHGNGTGTGGSSPGTTTAPNGDNKVNQRHYEPAERFIITKNVVVIGLAFMIHFTAFHGTSNLQSSVNADKALGTTTLAVIYGSLILSNIFLPMTVIRWFGCRLTMALALFAYMPYIAAQFYPRFETLIPAALMVGFGGGPLWCSKCTYLSTVSEALTQVRGNKSRKDVNTVKFFGLFFIFYQMAQVWGNLISSSVLTLSAPAAQSAANDSFELEVQRELERNRVAELCGARFCPGVGAEANPNLVPPAPEQIQLLNSIFLTCMAAAVVMMIFGVSSLKRYGVKRGDTGDGMSGLKLLTVTINLLRKRRQILMLPITMFIGLEEAFLAVDFTRSFVACGWGISRIGFAMICFGVANAVAAGIAGALVERIGRVTLAALCAVVNLCLLTYMYTWEAREGDYMSYCTFAAVWGICDGVWLVVVNAFYGILFPNHLIAAYSNFRLWESTGSVIGYVISSQLCTSTKLVILIIFILVGCVGYGLIEYRFWQKQKNLEVMLSD
InterPro domains: - IPR010291: Ion channel regulatory protein, UNC-93 (family) [95-414]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [65-515]
- IPR051951: UNC-93 regulatory protein (family) [51-515]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0006936 (muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Subtilisin-like serine protease (EC 3.4.21.62) (Tk-SP) (Q5JIZ5)
Organism: Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1))
Function: Serine protease with a broad substrate specificity.
Sequence: MKKFGAVVLALFLVGLMAGSVLAAPQKPAVRNVSQQKNYGLLTPGLFKKVQRMSWDQEVSTIIMFDNQADKEKAVEILDFLGAKIKYNYHIIPALAVKIKVKDLLIIAGLMDTGYFGNAQLSGVQFIQEDYVVKVAVETEGLDESAAQVMATNMWNLGYDGSGITIGIIDTGIDASHPDLQGKVIGWVDFVNGKTTPYDDNGHGTHVASIAAGTGAASNGKYKGMAPGAKLVGIKVLNGQGSGSISDIINGVDWAVQNKDKYGIKVINLSLGSSQSSDGTDSLSQAVNNAWDAGLVVVVAAGNSGPNKYTVGSPAAASKVITVGAVDKYDVITDFSSRGPTADNRLKPEVVAPGNWIIAARASGTSMGQPINDYYTAAPGTSMATPHVAGIAALLLQAHPSWTPDKVKTALIETADIVKPDEIADIAYGAGRVNAYKAAYYDNYAKLTFTGYVSNKGSQSHQFTISGAGFVTATLYWDNSGSDLDLYLYDPNGNQVDYSYTAYYGFEKVGYYNPTAGTWTIKVVSYSGSANYQVDVVSDGSLGQPSGGGSEPSPSPSPEPTVDEKTFTGTVHDYYDKSDTFTMTVNSGATKITGDLYFDTSYHDLDLYLYDPNQNLVDRSESSNSYEHVEYNNPAPGTWYFLVYAYDTYGYADYQLDAKVYYG
InterPro domains: - IPR007280: Peptidase, C-terminal, archaeal/bacterial (domain) [459-645]
- IPR017319: Subtilisin-like serine protease TK1689-type (family) [1-663]
- IPR041326: Tk-SP N-propeptide domain (domain) [37-103]
- IPR050131: Subtilisin-like serine protease (family) [84-555]
- IPR015500: Peptidase S8, subtilisin-related (family) [161-395]
- IPR023827: Peptidase S8, subtilisin, Asp-active site (active_site) [166-177]
- IPR022398: Peptidase S8, subtilisin, His-active site (active_site) [203-213]
- IPR023828: Peptidase S8, subtilisin, Ser-active site (active_site) [380-390]
- IPR000209: Peptidase S8/S53 domain (domain) [161-431]
- IPR036852: Peptidase S8/S53 domain superfamily (homologous_superfamily) [132-443]
- IPR037045: Peptidase S8 propeptide/proteinase inhibitor I9 superfamily (homologous_superfamily) [39-131]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [452-527]
Interaction partners: - Predicted zinc-dependent protease
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0005102 (signaling receptor binding), GO:0043169 (cation binding), GO:0005126 (cytokine receptor binding), GO:0008236 (serine-type peptidase activity), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)