Protein: alpha-1,2-Mannosidase (B0V2X9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)
Subcellular location: Endomembrane system; Single-pass type II membrane protein
Sequence: MTTPALLPLSGRRIPTLSPGASSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDNSKHKRFDFGLEDVLIPHIETEKESRHGSRQVIHGVGAHDEHRHREEEESLRDKIRADHERALQEAKEKLRKSKEELKAEIQTAKAKVSEDLKKKDGPKPLPPVPMPKLVGVNDGDPGDPDTKEKRDKIREMMKHAWDSYRQYGWGHNELKPLAKKGHSTNIFGNSQMGATIVDALDTLYIMGLHDEFKDGQEWIEQNLDFSVNAEVSVFEVNIRFIGGLLAAYYLSGQEVFKLKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASGGSSILAEFGTLHMEFVHLTYLTGNPAYYQKVMHIRKLLAKMDRPNGLYPNYLNPRTGRWGQHHTSVGGLGDSFYEYLLKAWLMSDKTDAEARKTYDDAIEAIERHLIRKSNGGLTFIGEWKNGHLERKMGHLTCFAGGMFALGADGSPDDKAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDSGLEAVAVRQNEKYYILRPEVIETYWYMWRFTHDPKYRQWGWEAAQAIDKHCRVSGGFSGVKDVYSSNPTYDDVQQSFFLAETLKYLYLLFSSDELLPLENWVFNTEAHPLPVLHLGNITLPGSESQR
InterPro domains: - IPR001382: Glycoside hydrolase family 47 (family) [191-630]
- IPR036026: Seven-hairpin glycosidases (homologous_superfamily) [179-630]
- IPR050749: Glycosyl Hydrolase Family 47 (family) [26-632]
- IPR012341: Six-hairpin glycosidase-like superfamily (homologous_superfamily) [167-637]
Interaction partners: - alpha-1,2-Mannosidase
- alpha-1,2-Mannosidase
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- alpha-1,2-Mannosidase
- Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
- Mannosyl-oligosaccharide glucosidase
- Alpha-mannosidase 2C1
- Alpha-mannosidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015923 (mannosidase activity), GO:0004559 (alpha-mannosidase activity), GO:0015924 (mannosyl-oligosaccharide mannosidase activity), GO:0004571 (mannosyl-oligosaccharide 1,2-alpha-mannosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072028 (nephron morphogenesis), GO:0009790 (embryo development), GO:0072006 (nephron development), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0060562 (epithelial tube morphogenesis), GO:0072009 (nephron epithelium development), GO:0061326 (renal tubule development), GO:0072176 (nephric duct development), GO:0072088 (nephron epithelium morphogenesis), GO:0072164 (mesonephric tubule development), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0060993 (kidney morphogenesis), GO:0072114 (pronephros morphogenesis), GO:0072080 (nephron tubule development), GO:0048793 (pronephros development), GO:0072073 (kidney epithelium development), GO:0072078 (nephron tubule morphogenesis), GO:0060675 (ureteric bud morphogenesis), GO:0072163 (mesonephric epithelium development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005798 (Golgi-associated vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)