Protein: LP12374p (Sterol regulatory element binding protein, isoform A) (Sterol regulatory element binding protein, isoform B) (Sterol regulatory element binding protein, isoform C) (Sterol regulatory element binding protein, isoform D) (Q9VW37)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MDTTLMNLIDAPLDESMDLFKAEDVFEPFDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQPQSVEQQPHVKSEHSSPVHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLLKAAQPTATIHHMDAQRMPPNTAVYPPSLGSSFVYQSMSPPTSPVESANQNVNVMQPVAATPAPASAPLPQQSYPQPFITYNSKAGMTSDEAMYFLLQPTVASPTPSPPVAPPPTSTGSRASKVRVAPLAPSPAAMEVQGKVPINRVQPKVKEVKRSAHNAIERRYRTSINDKINELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDLLQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDPSLSPMHSDISLPPSPYGGSTASCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFLQRGHYDSNDDLGDMSGQRRILSYDVEGEGFAVWQQSSWIWLLNFTLMLGCLVKLLVYGDPQLDAQTDAYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTTWQFLRFLFHRLWLGRVLSRRSGGLFSNAASRKQALASARELALLFNRLNQLQLTGNGSRGDMNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQECGLTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQYREHLLFKAIQCLVGAGHKSGGLPTSSVSGEAEQLQQQQHSGTIVSNVLKYTSLLKDTLWADEDERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKALHAVLRAKMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLLTCDWLLETRTALWELEHMNMEDDGFYQVPGEVLEKFQTDLNSLRNIVENIPNAQSRIYLYEAVCRLMAGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGGERERASAMYVACKYLPPALLSSPGERAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNGIGSVKA
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [283-339]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [280-358]
Interaction partners: - Membrane-bound transcription factor site-2 protease
- Niemann-Pick type C-1a, isoform A
- Mediator of RNA polymerase II transcription subunit 15
- Sterol regulatory element-binding protein cleavage-activating protein
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- Importin subunit beta
- Fatty acid synthase
- Membrane-bound transcription factor site-1 protease
- NPC intracellular cholesterol transporter 1 homolog 1b
- FI24210p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0019222 (regulation of metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0000902 (cell morphogenesis), GO:0009894 (regulation of catabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0055088 (lipid homeostasis), GO:0051128 (regulation of cellular component organization), GO:0006984 (ER-nucleus signaling pathway), GO:0006991 (response to sterol depletion), GO:0033554 (cellular response to stress), GO:0010506 (regulation of autophagy), GO:0055089 (fatty acid homeostasis), GO:0033043 (regulation of organelle organization), GO:0032933 (SREBP signaling pathway), GO:0031329 (regulation of cellular catabolic process), GO:0071501 (cellular response to sterol depletion), GO:0010821 (regulation of mitochondrion organization), GO:1903146 (regulation of autophagy of mitochondrion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0005634 (nucleus)