Protein: Elongation factor Tu (EF-Tu) (EC 3.6.5.3) (P23568)
Organism: Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
Sequence: MAREKFDRSKPHVNVGTIGHIDHGKTTLTAAICTVLAKEGKSAATRYDQIDKAPEEKARGITINSAHVEYSSDKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSATDSVMPQTREHILLARQVGVPRMVVFLNKCDIATDEEVQELVAEEVRDLLTSYGFDGKNTPIIYGSALKALEGDPKWEAKIHDLMNAVDEWIPTPEREVDKPFLLAIEDTMTITGRGTVVTGRVERGELKVGQEIEIVGLRPIRKAVVTGIEMFKKELDSAMAGDNAGVLLRGVDRKEVERGQVLAKPGSIKPHKKFKAEIYALKKEEGGRHTGFLNGYRPQFYFRTTDVTGSISLPENTEMVLPGDNTSITVELIAPIACEKGSKFSIREGGRTVGAGSVTEVLE
InterPro domains: - IPR041709: Elongation factor Tu (EF-Tu), GTP-binding domain (domain) [11-203]
- IPR004161: Translation elongation factor EFTu-like, domain 2 (domain) [225-294]
- IPR033720: Elongation factor Tu, domain 2 (domain) [211-297]
- IPR050055: Elongation factor Tu GTPase (family) [7-394]
- IPR005225: Small GTP-binding domain (domain) [13-152]
- IPR000795: Translational (tr)-type GTP-binding domain (domain) [10-204]
- IPR009001: Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal (homologous_superfamily) [298-393]
- IPR004541: Translation elongation factor EFTu/EF1A, bacterial/organelle (family) [1-394]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-226]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [205-301]
- IPR004160: Translation elongation factor EFTu/EF1A, C-terminal (domain) [298-392]
- IPR031157: Tr-type G domain, conserved site (conserved_site) [51-66]
Interaction partners: - Small ribosomal subunit protein uS3
- Large ribosomal subunit protein bL19
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein uL16
- Large ribosomal subunit protein bL21
- Small ribosomal subunit protein uS4
- Small ribosomal subunit protein uS17
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein uS12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010628 (positive regulation of gene expression), GO:0032677 (regulation of interleukin-8 production), GO:0032757 (positive regulation of interleukin-8 production), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)