Protein: Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein) (P28065)
Organism: Homo sapiens (Human)
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
Subcellular location: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
Sequence: MLRAGAPTGDLPRAGEVHTGTTIMAVEFDGGVVMGSDSRVSAGEAVVNRVFDKLSPLHERIYCALSGSAADAQAVADMAAYQLELHGIELEEPPLVLAAANVVRNISYKYREDLSAHLMVAGWDQREGGQVYGTLGGMLTRQPFAIGGSGSTFIYGYVDAAYKPGMSPEECRRFTTDAIALAMSRDGSSGGVIYLVTITAAGVDHRVILGNELPKFYDE
InterPro domains: - IPR023333: Proteasome B-type subunit (family) [18-213]
- IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [15-219]
- IPR001353: Proteasome, subunit alpha/beta (family) [17-198]
- IPR016050: Proteasome beta-type subunit, conserved site (conserved_site) [24-71]
- IPR000243: Peptidase T1A, proteasome beta-subunit (family) [28-195]
Interaction partners: - Proteasome subunit beta type-4
- Proteasome subunit beta type-7
- Proteasome subunit alpha type-1
- Proteasome subunit beta type-10
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-7
- Proteasome subunit beta type-8
- Proteasome subunit beta type-2
- Proteasome subunit beta type-3
- Proteasome maturation protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0045296 (cadherin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0043500 (muscle adaptation), GO:0042221 (response to chemical), GO:0002520 (immune system development), GO:0009607 (response to biotic stimulus), GO:0051716 (cellular response to stimulus), GO:0051707 (response to other organism), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0051602 (response to electrical stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0071214 (cellular response to abiotic stimulus), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0014889 (muscle atrophy), GO:0048534 (hematopoietic or lymphoid organ development), GO:0009615 (response to virus), GO:0010033 (response to organic substance), GO:0034097 (response to cytokine), GO:0098586 (cellular response to virus), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0048732 (gland development), GO:0014070 (response to organic cyclic compound), GO:0071257 (cellular response to electrical stimulus), GO:0048536 (spleen development), GO:0061008 (hepaticobiliary system development), GO:0048538 (thymus development), GO:0043279 (response to alkaloid), GO:0001889 (liver development), GO:0070555 (response to interleukin-1), GO:0071345 (cellular response to cytokine stimulus), GO:0071347 (cellular response to interleukin-1)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)