Protein: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2) (Spermatogenic glyceraldehyde-3-phosphate dehydrogenase) (O14556)
Organism: Homo sapiens (Human)
Function: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MSKRDIVLTNVTVVQLLRQPCPVTRAPPPPEPKAEVEPQPQPEPTPVREEIKPPPPPLPPHPATPPPKMVSVARELTVGINGFGRIGRLVLRACMEKGVKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGSVEFRNGQLVVDNHEISVYQCKEPKQIPWRAVGSPYVVESTGVYLSIQAASDHISAGAQRVVISAPSPDAPMFVMGVNENDYNPGSMNIVSNASCTTNCLAPLAKVIHERFGIVEGLMTTVHSYTATQKTVDGPSRKAWRDGRGAHQNIIPASTGAAKAVTKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAQPAPYSAIKEAVKAAAKGPMAGILAYTEDEVVSTDFLGDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [77-240]
- IPR020828: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (domain) [76-224]
- IPR006424: Glyceraldehyde-3-phosphate dehydrogenase, type I (family) [78-398]
- IPR020831: Glyceraldehyde/Erythrose phosphate dehydrogenase family (family) [76-404]
- IPR020829: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (domain) [229-386]
- IPR020830: Glyceraldehyde 3-phosphate dehydrogenase, active site (active_site) [222-229]
Interaction partners: - Triosephosphate isomerase
- Phosphoglycerate kinase 2
- Phosphoglycerate kinase 1
- Fructose-bisphosphate aldolase A
- Transaldolase
- Fructose-bisphosphate aldolase C
- Fructose-bisphosphate aldolase B
- Glucose-6-phosphate isomerase
- Bisphosphoglycerate mutase
- Transketolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0043891 (glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity), GO:0004365 (glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019318 (hexose metabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0006757 (ATP generation from ADP), GO:0043436 (oxoacid metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0006006 (glucose metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006096 (glycolytic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0019319 (hexose biosynthetic process), GO:0016310 (phosphorylation), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0006165 (nucleoside diphosphate phosphorylation), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0046939 (nucleotide phosphorylation), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0006094 (gluconeogenesis), GO:0046034 (ATP metabolic process), GO:0046031 (ADP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0006090 (pyruvate metabolic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)