Protein: Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c) (O75023)
Organism: Homo sapiens (Human)
Function: May act as receptor for class I MHC antigens.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MTLTLSVLICLGLSVGPRTCVQAGTLPKPTLWAEPASVIARGKPVTLWCQGPLETEEYRLDKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYYETPAGWSEPSDPLELVATGFYAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVEEEQKLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCYYYYRKNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVARGGSLTLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHNLSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQIDTFFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGTYRCYSAIRSYPYLLSSPSYPQELVVSGPSGDPSLSPTGSTPTPGPEDQPLTPTGLDPQSGLGRHLGVVTGVSVAFVLLLFLLLFLLLRHRHQSKHRTSAHFYRPAGAAGPEPKDQGLQKRASPVADIQEEILNAAVKDTQPKDGVEMDAPAAASEAPQDVTYAQLHSLTLRREATEPPPSQEREPPAEPSIYAPLAIH
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [26-419]
- IPR007110: Immunoglobulin-like domain (domain) [27-98]
- IPR050412: Immunoglobulin-like Receptors in Immune Regulation (family) [8-218]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [25-417]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [232-398]
- IPR003598: Immunoglobulin subtype 2 (domain) [40-402]
- IPR003599: Immunoglobulin domain subtype (domain) [34-418]
Interaction partners: - Tyrosine-protein phosphatase non-receptor type 6
- Tyrosine-protein kinase SYK
- CMRF35-like molecule 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0023023 (MHC protein complex binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0046983 (protein dimerization activity), GO:0042277 (peptide binding), GO:0042802 (identical protein binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0140375 (immune receptor activity), GO:0042287 (MHC protein binding), GO:0042169 (SH2 domain binding), GO:0042803 (protein homodimerization activity), GO:0019902 (phosphatase binding), GO:0001540 (amyloid-beta binding), GO:0042288 (MHC class I protein binding), GO:0019903 (protein phosphatase binding), GO:0008157 (protein phosphatase 1 binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0051051 (negative regulation of transport), GO:0007155 (cell adhesion), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0002695 (negative regulation of leukocyte activation), GO:0051129 (negative regulation of cellular component organization), GO:0043207 (response to external biotic stimulus), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0050803 (regulation of synapse structure or activity), GO:1903706 (regulation of hemopoiesis), GO:0050866 (negative regulation of cell activation), GO:0007162 (negative regulation of cell adhesion), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:1903708 (positive regulation of hemopoiesis), GO:0051128 (regulation of cellular component organization), GO:0050865 (regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0002764 (immune response-regulating signaling pathway), GO:0045597 (positive regulation of cell differentiation), GO:0002577 (regulation of antigen processing and presentation), GO:0051049 (regulation of transport), GO:0098609 (cell-cell adhesion), GO:0008285 (negative regulation of cell population proliferation), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0045785 (positive regulation of cell adhesion), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0050867 (positive regulation of cell activation), GO:0002643 (regulation of tolerance induction), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0043271 (negative regulation of monoatomic ion transport), GO:0050807 (regulation of synapse organization), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0002237 (response to molecule of bacterial origin), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0034113 (heterotypic cell-cell adhesion), GO:0051251 (positive regulation of lymphocyte activation), GO:0006968 (cellular defense response), GO:1902105 (regulation of leukocyte differentiation), GO:0070665 (positive regulation of leukocyte proliferation), GO:0022408 (negative regulation of cell-cell adhesion), GO:1901701 (cellular response to oxygen-containing compound), GO:0019221 (cytokine-mediated signaling pathway), GO:0051249 (regulation of lymphocyte activation), GO:0034097 (response to cytokine), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0071310 (cellular response to organic substance), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0010639 (negative regulation of organelle organization), GO:0033993 (response to lipid), GO:1902107 (positive regulation of leukocyte differentiation), GO:0070664 (negative regulation of leukocyte proliferation), GO:0033043 (regulation of organelle organization), GO:0051926 (negative regulation of calcium ion transport), GO:0043269 (regulation of monoatomic ion transport), GO:0071222 (cellular response to lipopolysaccharide), GO:0050670 (regulation of lymphocyte proliferation), GO:0045619 (regulation of lymphocyte differentiation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0045621 (positive regulation of lymphocyte differentiation), GO:0010959 (regulation of metal ion transport), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0071345 (cellular response to cytokine stimulus), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:0050870 (positive regulation of T cell activation), GO:0099175 (regulation of postsynapse organization), GO:1905874 (regulation of postsynaptic density organization), GO:0071396 (cellular response to lipid), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0050868 (negative regulation of T cell activation), GO:0045582 (positive regulation of T cell differentiation), GO:0051924 (regulation of calcium ion transport), GO:0042130 (negative regulation of T cell proliferation), GO:0042102 (positive regulation of T cell proliferation), GO:0042129 (regulation of T cell proliferation), GO:0045580 (regulation of T cell differentiation), GO:0045589 (regulation of regulatory T cell differentiation), GO:0045591 (positive regulation of regulatory T cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0101002 (ficolin-1-rich granule), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030667 (secretory granule membrane), GO:0070820 (tertiary granule), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0070821 (tertiary granule membrane), GO:0101003 (ficolin-1-rich granule membrane)