Protein: Ubiquitin fusion degradation protein 3 homolog (G5EES6)
Organism: Caenorhabditis elegans
Function: Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25721663}.
Sequence: MADDGLGDVPMETESMPQYTISHVIEAHKSDTKALAVTQGGCLISGGRDETVKFWAKKGKQYTKTHAFEQPKGITVNSIAYAELADGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKATHMLSGSWDSNVIIWPITELNSSSFTFQTIVCPGHTLSVWALASFPDLPNTYLSASADKTIRMWFGDTTLSVFKGHTDVVRALVVLSSSHFLSAGNDGHIIHWDVASASILRKFATQAHEFIYSMTLSDSHILTTGEDGTLEFWAIDGGKDGNLAIVSEAVIQLPTTNTWDAKVLLNSDIAVAGSDGRIYIMTTDKNRKADDDILDAFDAEVVAKLTAKTERMKQEEHETVTIKVDIDDRPTQLNLKYKKGTDPGLCAQEFLSENNLPIHYLEEITRFIKDRIPEARAFDLKSGKKVIVDGKEYDYALGVNFGKGEPDKQMPFNVNESPQFAAQRFVERHQLPVSVIPSLAGMISQEMDKLSKGAASAQSGYEDPFTGPGRYVPQGSSNSGGHGADPFTGSGRYVPQASNSSGFDTGFSGDPLTGDGGYRASAPENTGSHAVPLSSLPQNKKKPRGPLVPVPDFYIIGLAGKGEKAIAKLKELNEKQDAFQLNPDQINGLEELFVLPTSSNYSSEVTQSAFEMSLQWPVEHLTPVLDFLRIALTHHSLNSYFCDRERGQELVGRLIAILVSDPADVALKVLVCRCIANAFSHPVGRNLFASTELSTLAPLVVRQVLNEKTVLQMSAATALANWSLALLQQSEQCEQLGPKEDLLRAILNGIESVDSFGYLGEDAIIRLLQALVTVMWGDASVIRLAKNRNIAQIAARLKDAVSNDSGKNIARDIVEMTYAV
InterPro domains: - IPR001680: WD40 repeat (repeat) [18-274]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [13-340]
- IPR011989: Armadillo-like helical (homologous_superfamily) [588-856]
- IPR013535: PUL domain (domain) [586-856]
- IPR038122: PFU domain superfamily (homologous_superfamily) [346-504]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [17-328]
- IPR015155: PLAA family ubiquitin binding domain (domain) [362-497]
Interaction partners: - Ubiquitin fusion degradation protein 1 homolog
- UBX domain-containing protein 2
- Ubiquitin conjugation factor E4 ufd-2
- Nuclear protein localization protein 4 homolog 2
- Nuclear protein localization protein 4 homolog 1
- Transitional endoplasmic reticulum ATPase homolog 1
- UBX domain-containing protein 6
- UBX domain-containing protein 1
- DUF19 domain-containing protein
- Transitional endoplasmic reticulum ATPase homolog 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:2000243 (positive regulation of reproductive process), GO:0007275 (multicellular organism development), GO:2000241 (regulation of reproductive process), GO:0051321 (meiotic cell cycle), GO:0007163 (establishment or maintenance of cell polarity), GO:0022402 (cell cycle process), GO:0051240 (positive regulation of multicellular organismal process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:1903046 (meiotic cell cycle process), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0051640 (organelle localization), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0090130 (tissue migration), GO:0051653 (spindle localization), GO:0051656 (establishment of organelle localization), GO:0007051 (spindle organization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0000226 (microtubule cytoskeleton organization), GO:0033206 (meiotic cytokinesis), GO:0040038 (polar body extrusion after meiotic divisions), GO:0007283 (spermatogenesis), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)