Protein: Akirin-2 (Fourteen-three-three beta interactant 1) (Fourteen-three-three beta interacting-protein 1) (Q25C79)
Organism: Rattus norvegicus (Rat)
Function: Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity). Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity). Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6. Also involved in adaptive immunity by promoting B-cell activation. Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells. Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors. Also plays a role in facilitating interdigital tissue regression during limb development (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:18460465}. Cytoplasm {ECO:0000250|UniProtKB:B1AXD8}. Membrane {ECO:0000250|UniProtKB:B1AXD8}. Note=Present mainly in the nuclear fraction, and at much lower level in the cytoplasmic and membrane fractions. {ECO:0000250|UniProtKB:B1AXD8}.
Sequence: MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAATAAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQTDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEKVREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS
InterPro domains: - IPR024132: Akirin (family) [1-201]
Interaction partners: - NF-kappa-B inhibitor zeta
- DNA methyltransferase 1-associated protein 1
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-2
- Proteasome subunit beta type-2
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-3
- LOC100125377 protein.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0032870 (cellular response to hormone stimulus), GO:0014070 (response to organic cyclic compound), GO:1901654 (response to ketone), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:1901701 (cellular response to oxygen-containing compound), GO:1901655 (cellular response to ketone), GO:0031960 (response to corticosteroid), GO:0071548 (response to dexamethasone), GO:0071383 (cellular response to steroid hormone stimulus), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0051384 (response to glucocorticoid), GO:0071384 (cellular response to corticosteroid stimulus), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)