Protein: Stromal interaction molecule 2 (D4A5X1)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MNAAGCRAPRAAGEGSGLAPGGSLLPRRRGPGQLAASECPAAPVSAPPAAAPGRALGRPSRRRWAAMLLFGLLVAGVADGCDLVPRHLRGRRASGSAGAAASPSAAAAGERQALLTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVDESDEFIREDMKYKDATNKHSHLHREDKHITVEDLWKQWKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHETSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTISIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRTVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTVAKPAGSLARSSSLCRSRRSIVPSSPQSQRAQLPAHAPLAAHPRHPHHPQHSLPSPDPDILSVSSCPALYRNEEEEEAIYFTAEKQWEVPDTASECDSLNSSIGRKQSPPSSLEIYQTLSSRKISRDELSLEDSSRGDSPVTADVSRGSPECVGLTETKSMIFSPASRVYNGILEKSCSMHQLSSGIPVPNPRHTSCSLAGSDSKPVQEASSVSRVGSIPHDLCHNGEKSKKPSKIKSLFKKKSK
InterPro domains: - IPR037608: STIM1/2 (family) [64-809]
- IPR057835: STIM1/2, EF-hand (domain) [117-195]
- IPR001660: Sterile alpha motif domain (domain) [199-270]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [191-273]
- IPR032393: STIM1/2, Orai1-activating region (domain) [411-511]
- IPR037610: Stromal interaction molecule 2, SAM domain (domain) [198-271]
Interaction partners: - Protein orai-3
- Calcium release-activated calcium modulator 2 protein
- Stromal interaction molecule 1
- Calcium release-activated calcium channel protein 1
- Short transient receptor potential channel 1
- Transient receptor potential Ca2+ channel 6A
- Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1
- Short transient receptor potential channel 3
- Store-operated calcium entry-associated regulatory factor
- Nuclear factor of activated T-cells 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0016247 (channel regulator activity), GO:0099106 (ion channel regulator activity), GO:0005246 (calcium channel regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0032409 (regulation of transporter activity), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0051928 (positive regulation of calcium ion transport), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0022898 (regulation of transmembrane transporter activity), GO:0043269 (regulation of monoatomic ion transport), GO:2001259 (positive regulation of cation channel activity), GO:1901021 (positive regulation of calcium ion transmembrane transporter activity), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:1904064 (positive regulation of cation transmembrane transport), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0010959 (regulation of metal ion transport), GO:1904427 (positive regulation of calcium ion transmembrane transport), GO:0051924 (regulation of calcium ion transport), GO:2001257 (regulation of cation channel activity), GO:1901019 (regulation of calcium ion transmembrane transporter activity), GO:1903169 (regulation of calcium ion transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)