Protein: Selenocysteine-specific elongation factor (EC 3.6.5.-) (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific) (mSelB) (Q9JHW4)
Organism: Mus musculus (Mouse)
Function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Sequence: MAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGFSCFVVPLPGAEPGSSDTLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLAEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGISELIELLKSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGTISLGDSVEIPALKVVKKVKSMQMFHTPVTSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRTLFFSPAPDSFDLEPVLDSFDLSREYLFQEQYLCKDSMPTATEGDDEADPKAGHAPGGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGVLLQGLEDKNYIESFLPALRVYKLKHKHGLVERVMDDYSVIGRSLFKKETNIQLFVGLKVQLSTGEQGIIDSAFGQSGKFKIHIPGGLSPESKKILTPTLKKRSRAGRGETTKPEEGTERPEPIQPVTLNLSFKRYVFDTQKRMVQTP
InterPro domains: - IPR004161: Translation elongation factor EFTu-like, domain 2 (domain) [224-287]
- IPR049393: Selenocysteine-specific elongation factor, 3rd domain (domain) [303-435]
- IPR049394: Selenocysteine-specific elongation factor, C-terminal RIFT domain (domain) [452-577]
- IPR050055: Elongation factor Tu GTPase (family) [5-437]
- IPR000795: Translational (tr)-type GTP-binding domain (domain) [5-203]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [5-225]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [202-292]
Interaction partners: - Selenocysteine insertion sequence-binding protein 2
- Ubiquitin-like protein FUBI
- O-phosphoseryl-tRNA
- L-seryl-tRNA
- Eukaryotic translation initiation factor 2 subunit 2
- tRNA selenocysteine 1-associated protein 1
- Eukaryotic translation initiation factor 2 subunit 1
- Selenide, water dikinase 1
- Small ribosomal subunit protein uS3
- Small ribosomal subunit protein eS6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0007272 (ensheathment of neurons), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0048469 (cell maturation), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0042552 (myelination), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0043588 (skin development), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0032291 (axon ensheathment in central nervous system), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0008544 (epidermis development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0045444 (fat cell differentiation), GO:0009266 (response to temperature stimulus), GO:0042063 (gliogenesis), GO:0022010 (central nervous system myelination), GO:0014003 (oligodendrocyte development), GO:0048709 (oligodendrocyte differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0022011 (myelination in peripheral nervous system), GO:0014044 (Schwann cell development), GO:0006355 (regulation of DNA-templated transcription), GO:0042063 (gliogenesis), GO:0030216 (keratinocyte differentiation), GO:0009913 (epidermal cell differentiation), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)