wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Bub3 interacting GLEBS and zinc finger domain protein, isoform A (GH18623p) (Q9VJI6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGRKKKKASKPWCWYCNREFDDEKILVQHQKAKHFKCHICHKKLYTGPGLSIHCMQVHKETVDKVPNSLPNRSNIEVEIFGMDGIPAEDLRDHERQKNGGKSDSDDDEPVAKKKVEYAMSVPPPMMMPPNMMPPHMLGQYGMGMMQHMPPLPPYPVPMMPHMMPPRPLFPAAMATTSAAAAAAAAHHHHAAAMAQQKPTFPAYSNATISAPPTTNHAGGASSAPPSGPPDAQQHQQRPPAPPAASGTSAAAVTTKIMHPQEDLSLEELRARQPKIQARLAAALASLANPQSRKSPSNNGGPSTSIPTTPPPPSLAGISPTGSNSSSGMANSIVVSAAMSKAQEVSSYHSYRNHSQYK
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [11-58]
- IPR003656: Zinc finger, BED-type (domain) [6-65]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0016358 (dendrite development), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0048813 (dendrite morphogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0032990 (cell part morphogenesis), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048699 (generation of neurons), GO:0031175 (neuron projection development), GO:0048812 (neuron projection morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Histone H3K27 methylase (O41094)
Organism: Paramecium bursaria Chlorella virus 1 (PBCV-1)
Function: Not known
Sequence: MFNDRVIVKKSPLGGYGVFARKSFEKGELVEECLCIVRHNDDWGTALEDYLFSRKNMSAMALGFGAIFNHSKDPNARHELTAGLKRMRIFTIKPIAIGEEITISYGDDYWLSRPRLTQN
InterPro domains: - IPR009207: Histone-lysine N-methyltransferase, H3 lysine-37 specific (family) [2-118]
- IPR046341: SET domain superfamily (homologous_superfamily) [1-119]
- IPR001214: SET domain (domain) [4-112]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0090068 (positive regulation of cell cycle process), GO:0042127 (regulation of cell population proliferation), GO:0010564 (regulation of cell cycle process), GO:0008284 (positive regulation of cell population proliferation), GO:0045787 (positive regulation of cell cycle), GO:1901989 (positive regulation of cell cycle phase transition), GO:1901987 (regulation of cell cycle phase transition), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902808 (positive regulation of cell cycle G1/S phase transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: DND microRNA-mediated repression inhibitor 1 (Dead end protein homolog 1) (F1RGE0)
Organism: Sus scrofa (Pig)
Function: Not known
Sequence: MQSKRECELWCERVNPENKAALEAWVRETGIRLVQVNGQRKYGGPPPGWVGSPPPAGSEVFIGRLPQDVYEHQLIPLFQRVGRLYEFRLMMTFSGLNRGFAYARYSSRRGAQAAIATLHNHPLRPSCPLLVCRSTEKCELSVDGLPPGLSRRALLLALQPLGPGLQEALLLPSPGPAPAQIALLKFSSHRAAAMAKKALVEGQSHLCGEQVAVEWLKPDLKQRLRQQLMGPSLRCLQSEGSQLALARDKLESQGARAALQLLCQRMKLGTPVFLTKCLGTGPATWHHFWYQVVIPGHPVPFSGLIWVVLASDGQDGHEVAKEAVSARLLETLSESGASLLRSAVAEAGTMVQQ
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [56-218]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [37-216]
- IPR034414: Dead end protein 1, RNA recognition motif 1 (domain) [57-134]
- IPR044448: DND1, double-stranded RNA binding domain (domain) [254-333]
- IPR000504: RNA recognition motif domain (domain) [58-136]
Interaction partners: - Nanos C2HC-type zinc finger 3
- Deleted in azoospermia-like protein.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007292 (female gamete generation), GO:0048477 (oogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: ATP-dependent zinc metalloprotease FTSH 1 (EC 3.4.24.-) (Q8I526)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MSSKYDNQSFLSTGSDKYGEQENSVLLHDEEDEYINENKKKRNERDKKFRYYENFFNRRRSKKWNYFIIFFLGVCLGFAIWPFFMTIITYRLFYKDNFNNTNYRTNNSSTSLKSYGNEKNKKSDNNGKVPMKDQSPNKVSPHFKPIRFEEIAGIDESKLELLEVVDFIKNREKYHEMGARMPKGVLLVGPPGSGKTMLARAVATEANVPYIYTSGPEFIEIYVGQGAKRIRQLFAHARSVAPSIVFIDEIDAIGGKRSSGSVNGAGQREHDQTLNQLLVEMDGFSNTVHIMVIGATNRIDTLDSALLRPGRFDRIVYVPLPDINGRKKILEIYIKKIKSDLKLEDIEKIARLTPGFSGADLENVVNEATILATRNNKSLVTINELYEARDKVSMGPERKSLRQSDHQRRITAYHEAGHAIVAYFLQPKTDPIHKATIISRGNALGYVEQIPVDDRHNYFKSQMEAKLAVCMGGRTAEEIVFGKSETSSGASSDISRATEIAYKMVTEWGMSDKLGPLNYKKRMGDGYSSNRLSAQTVSSIEVEVKSLVEKGKSLSEEILRRHRKELDNLAFALLDKETLSGEEIKNIIDPNNSKNYSGKVEMLKNDTKKNEKKSNSVSKNKSTISEDYDKNQNNVEQNYQSHDHTLVKNEENLNNMKNDIDDNNTRDGQVNSDSFVKRKEVTDQDINGKELSEMDNKEIKENKKLDGEELNKIIIDNDKMGDMKKNIKEVIKKMKKKQSKGSYKTYKNVLKSVSEHKELKTQKKADENKIVADNNEKSSNNSLDKNNTQGSIDEKGYKNNNNNNNNMVKNINELFEENFPEYKKYDNENNDFVKTKENYFDNFNEVIDISHIKNVDEMKKFNIFEHNLNKLFLFDIFKSD
InterPro domains: - IPR000642: Peptidase M41 (domain) [404-587]
- IPR003593: AAA+ ATPase domain (domain) [181-322]
- IPR041569: AAA ATPase, AAA+ lid domain (domain) [345-384]
- IPR003959: ATPase, AAA-type, core (domain) [185-320]
- IPR037219: Peptidase M41-like (homologous_superfamily) [398-597]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [127-391]
- IPR005936: ATP-dependent zinc metalloprotease, FtsH (family) [1-593]
- IPR003960: ATPase, AAA-type, conserved site (conserved_site) [290-308]
Interaction partners: - Prohibitin
- ATP-dependent protease subunit ClpQ
- Prohibitin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0006457 (protein folding), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0030163 (protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cytochrome c (P53698)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location: Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Sequence: MPAPFEKGSEKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGVFGRKSGLAEGYSYTDANKKKGVEWTEQTMSDYLENPKKYIPGTKMAFGGLKKPKDRNDLVTYLKKATS
InterPro domains: - IPR009056: Cytochrome c-like domain (domain) [8-109]
- IPR036909: Cytochrome c-like domain superfamily (homologous_superfamily) [5-110]
- IPR002327: Cytochrome c, class IA/ IB (family) [6-108]
Interaction partners: - Cytochrome b-c1 complex subunit Rieske, mitochondrial
- Cytochrome b-c1 complex catalytic subunit, mitochondrial
- Cytochrome b
- Cytochrome b-c1 complex subunit 7, mitochondrial
- Cytochrome c oxidase subunit 4, mitochondrial
- Cytochrome c oxidase subunit Va
- Cytochrome c oxidase subunit 1
- Elongation factor Tu
- Cytochrome c oxidase subunit 2
- Cytochrome b-c1 complex subunit 9, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ganglioside-induced differentiation-associated protein 1 (GDAP1) (Q8TB36)
Organism: Homo sapiens (Human)
Function: Regulates the mitochondrial network by promoting mitochondrial fission.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:15772096, ECO:0000269|PubMed:16172208, ECO:0000269|PubMed:16857173}; Multi-pass membrane protein {ECO:0000269|PubMed:16172208}. Cytoplasm {ECO:0000250|UniProtKB:O88741}.
Sequence: MAERQEEQRGSPPLRAEGKADAEVKLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGTTLVVGLLAGVGYFAFMLFRKRLGSMILAFRPRPNYF
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [24-105]
- IPR034336: Ganglioside-induced differentiation-associated protein 1, C-terminal domain (domain) [179-289]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [202-300]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [153-309]
- IPR040079: Glutathione transferase family (family) [27-286]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [24-105]
Interaction partners: - Mitofusin-2
- Mitofusin-1
- Mitochondrial fission 1 protein
- mRNA cap guanine-N
- Myelin P2 protein
- Myelin protein zero-like protein 1
- SH3 domain and tetratricopeptide repeat-containing protein 2
- Ras-related protein Rab-6B
- Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
- Myotubularin-related protein 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004601 (peroxidase activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor), GO:0004602 (glutathione peroxidase activity), GO:0016746 (acyltransferase activity), GO:0050839 (cell adhesion molecule binding), GO:0004364 (glutathione transferase activity), GO:0045296 (cadherin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cytokine induced apoptosis inhibitor 1 (H3BQ23)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MADFGISAGQFVAVVWDKSSPVEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEILAEIARILRPGGCLFLKEPVETAVDNNSKVKTASKLCSALTLSGLVEVKE
InterPro domains: - IPR007785: Anamorsin (family) [7-128]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [1-129]
- IPR049011: Anamorsin, N-terminal domain, metazoan-type (domain) [9-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043933 (protein-containing complex organization), GO:0006479 (protein methylation), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0008213 (protein alkylation), GO:0018193 (peptidyl-amino acid modification), GO:0018195 (peptidyl-arginine modification), GO:0018205 (peptidyl-lysine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Phytoene dehydrogenase (Q9RW08)
Organism: Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
Function: Not known
Sequence: MTSALPRPAPSPYARRKTALVIGAGFGGLALGIRLQSLGFDTTILERLDGPGGRAYQKRTPDGYVFDMGPTVLTVPHFIEELFALERDRAGLDAPDYPPEVLSGERVKEGVSGGPHTSRYVTLVPILPFYRIVFHDGTYFDYDGDPESTRRQIAELAPGDLAGYERFHADAEAIFRRGFLELGYTHFGDVPTMLRVVPDLLKLDAVRTLFSFTSKYFQSDKLRQVFSFETLLVGGNPLSVPAIYAMIHFVEKTWGIHYAMGGTGALVRGLVQKFEELGGAIRYGAGVDEVLVDGNLPGKRTARGVRLESGEELRADLVASNGDWANTYLKRVRPSARLVNSDLRVKAASESMSLLVVYFGFRGGDDLPLKHHNILLGPRYEALLSEIFGTKRLGEDFSQYLHVPTLTDPALAPAGHHAAYTLVPVPHNGSGIDWDVEGPKLAEAALADIERRGLIPGLRERLTHFEFITPDYFAGTLDSYLGNAFGPEPRLVQSAFFRPHNRSEDLHNFYLVGAGAQPGAGTPSVMMSAKMTARLIAEDFGIHADIRR
InterPro domains: - IPR002937: Amine oxidase (domain) [27-536]
- IPR014105: Carotenoid/retinoid oxidoreductase (family) [114-541]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [16-539]
Interaction partners: - Phytoene synthase
- Uncharacterized carotenoid cyclase DR_0801
- Carotenoid biosynthesis protein
- Dehydrogenase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:1901265 (nucleoside phosphate binding), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0050660 (flavin adenine dinucleotide binding), GO:0071949 (FAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0016119 (carotene metabolic process), GO:0046246 (terpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Signal recognition particle subunit srp14 (Signal recognition particle 14 kDa protein homolog) (Q9P372)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MLLSNEEFLKKLTDLLQTHQSKGTGSVYLSQKCNPVDEGEGSSASVLIRAKSGAAEKISTVVELDYFTDFFQSYAEVCKGQIVGLKKRDRKKTKKNKKKTTSSGHT
InterPro domains: - IPR003210: Signal recognition particle, SRP14 subunit (family) [2-101]
- IPR009018: Signal recognition particle, SRP9/SRP14 subunit (homologous_superfamily) [1-91]
Interaction partners: - Signal recognition particle sec65 subunit
- Signal recognition particle subunit srp72
- Uncharacterized protein C17H9.07
- Signal recognition particle subunit srp68
- Signal recognition particle subunit SRP54
- Signal recognition particle receptor subunit beta
- Signal recognition particle receptor subunit alpha homolog
- Large ribosomal subunit protein eL14
- Large ribosomal subunit protein eL18A
- Large ribosomal subunit protein uL29
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0033365 (protein localization to organelle), GO:0006612 (protein targeting to membrane), GO:0006605 (protein targeting), GO:0072599 (establishment of protein localization to endoplasmic reticulum), GO:0045047 (protein targeting to ER), GO:0070972 (protein localization to endoplasmic reticulum), GO:0006613 (cotranslational protein targeting to membrane), GO:0006614 (SRP-dependent cotranslational protein targeting to membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)