Protein: Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Retinoblastoma-binding protein 4) (RBBP-4) (Q6P3H7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q09028}. Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}.
Sequence: MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSVHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPTSDVLVFDYTKHPSKPDPSGECTPDLRLRGHQKEGYGLSWNPNLRSCLLSASDDHTICLWDISTVPKEGKIVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHAVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGAADTEVQG
InterPro domains: - IPR001680: WD40 repeat (repeat) [112-404]
- IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [193-347]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [114-409]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [1-424]
- IPR022052: Histone-binding protein RBBP4-like, N-terminal (domain) [19-88]
- IPR050459: WD repeat RBAP46/RBAP48/MSI1 (family) [8-413]
- IPR019775: WD40 repeat, conserved site (conserved_site) [193-347]
Interaction partners: - Polycomb protein suz12-A
- Polycomb protein suz12-B
- Histone-lysine N-methyltransferase EZH2
- Protein lin-9 homolog
- Lin-37 DREAM MuvB core complex component.
- Polycomb protein eed
- Zinc finger protein AEBP2
- Histone deacetylase 1
- Protein lin-54 homolog
- Protein lin-52 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048589 (developmental growth), GO:0031099 (regeneration), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0042246 (tissue regeneration), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis), GO:0031101 (fin regeneration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005667 (transcription regulator complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:1990234 (transferase complex), GO:0070603 (SWI/SNF superfamily-type complex), GO:0000118 (histone deacetylase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0016581 (NuRD complex), GO:0043228 (non-membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043233 (organelle lumen), GO:0035097 (histone methyltransferase complex), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0090545 (CHD-type complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0035098 (ESC/E(Z) complex), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome)