Protein: IQ motif containing GTPase activating protein 3 (B9EKT6)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MEPCAAGRARTAYERLTAEEMDEQRRQNVAYQYLCRLEEAKRWMEVCLKEELPSPVELEESLRNGVLLAKLGHCFAPSVVPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAVAHIGLPSIFLPETTDIYDKKNMPRVIYCIHALSLFLFRLGLAPQIHDLYGKVKFTAEELGNIASELAKYGLQLPAFSKIGGILANEFSADEAAVHAAILAINDAVERGVVEDTLVTLQNPNALLGNLREPLAAVYQELLALAKMEKAANARNHDDGQEQDIYESCLTQAEIQGHINLANVQGALEVVDDALERQNPGALLEALHDPVLALQGVRGTFADWYLEQLTSDREQKSQELGLVRLLEKEEIQAGVAVANEKGNEEQTMLQAVWRINKAIRRGVAADTVKELMCPEAQLPRVYPFASAFYQQELALLQKQQQGELGQEELFVAVEMLSAVVLINRALEAGDVCAFWDNLVNPATGLAQVEEENAQRYFDALVKVQQFQGTHRGILSWNDLQAAVSQVNEQVQEETDQVLAISLINEALDQGCPEKTLSALLLPAAGLEDVSLHVAPRYHLLLVAAKRQKARVTGDPGAVLWLEEIRQGVARANEDTSTAQRIALGVAAINQAIKEGKAAQTERVLRNPNVALRGIVPDCAKSYQQALEGAAAKKQCPGDTAFWVQHDMKDGTAYYLHLQTFQGTWEHPSGCHLNTSHLTWEEIQSVITKVTAAHDRQLLWKANVGFVIKLQARLRGFLVRQKFAESSHVFRTLLPAVIKIQAHWRGYRQRKAYQERLQHFKANLDAIIKIQAWARMWAARRRYLRRLRYFQKNVDSVVKIQAFFRARKARDDYRMLVHARHPPLCVVRKFAHLLNQSQEDFSAEAELLKLQEEVVRKIRSNQQLEQDLNLMDIKIGLLVKNRITLQEVVSHCKKLTKKNKEQLSDMMILDKQKGLKSLSREKRQKLEAYQHLFYLLQTQPIYLAKLIFQMPQNKTTKFMEGVIFSLYNYASNRREAYLLLQLFRTALQEEIKSKVEQPQDVVTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDRSVSIHTDPVHIYKSWINQEEAQTGQRSHLPYDVTPEQALSHSEVQRRLDISLRSLLTLTEKFFVAISSSVDHIPYGMRYMAKVLKTTLEKKFPNATERDIYKVVGNLLYYRFLNPAVVAPDAFDIVAMVAGSTLAAPQRHALGAVAQLLQHAAAGQIFSGESRHLRVLNDYLEDLHLKFRKFICRACRVPEPEERFAIDEYSDMVAVAKPMVYITVGELIGTHRLLLEHQDQLAPGHQDPLHQLLEDLGEPPTISDLIGDNIATDGHVDLSRLEVSLTLTNKFEGLETDADHNSNQSLLLSTKQMLADLIQFHPGESLEEILTSSAPREHEEAHRRLMCWRQACDTQKPEPLRRHHSLMAHSLLSLSEKQQRVLRNLRRLQGLGLVRASDCYQGLVDELAKDICNQRRHRQRRKAEMLRLRTTLQGLDAKTIFYEEQGDYYNQYIQACLDHLAPKPKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPVSHFRNVIFDITPGDEAGRFFVNAKFLGVDMEKFQLHYQDLLQLQYEGVAVMKLFNKAKVNVNLLIFLLNKKFLRK
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [18-190]
- IPR001202: WW domain (domain) [671-698]
- IPR000048: IQ motif, EF-hand binding site (binding_site) [730-842]
- IPR000593: RasGAP protein, C-terminal (domain) [1434-1556]
- IPR023152: Ras GTPase-activating protein, conserved site (conserved_site) [1174-1188]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [733-818]
- IPR001715: Calponin homology domain (domain) [34-149]
- IPR001936: Ras GTPase-activating domain (domain) [977-1330]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [944-1330]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0048584 (positive regulation of response to stimulus), GO:0022402 (cell cycle process), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1903047 (mitotic cell cycle process), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0006793 (phosphorus metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0050673 (epithelial cell proliferation), GO:0044770 (cell cycle phase transition), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0090066 (regulation of anatomical structure size), GO:0000278 (mitotic cell cycle), GO:0008284 (positive regulation of cell population proliferation), GO:0032535 (regulation of cellular component size), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0044843 (cell cycle G1/S phase transition), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0033598 (mammary gland epithelial cell proliferation), GO:0000165 (MAPK cascade), GO:0048732 (gland development), GO:0010628 (positive regulation of gene expression), GO:0006796 (phosphate-containing compound metabolic process), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0036211 (protein modification process), GO:0044772 (mitotic cell cycle phase transition), GO:0043412 (macromolecule modification), GO:0051247 (positive regulation of protein metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007264 (small GTPase mediated signal transduction), GO:0060429 (epithelium development), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0030879 (mammary gland development), GO:0043408 (regulation of MAPK cascade), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0006468 (protein phosphorylation), GO:0008361 (regulation of cell size), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:0033599 (regulation of mammary gland epithelial cell proliferation), GO:0007265 (Ras protein signal transduction), GO:0070371 (ERK1 and ERK2 cascade), GO:0000082 (G1/S transition of mitotic cell cycle), GO:0043410 (positive regulation of MAPK cascade), GO:0031401 (positive regulation of protein modification process), GO:0061180 (mammary gland epithelium development), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0016328 (lateral plasma membrane), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)