Protein: Spermidine export protein MdtI (P69210)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS
Subcellular location: Cell inner membrane; Multi-pass membrane protein
Sequence: MAQFEWVHAAWLALAIVLEIVANVFLKFSDGFRRKIFGLLSLAAVLAAFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMIMVKLA
InterPro domains: - IPR037185: Multidrug transporter EmrE superfamily (homologous_superfamily) [12-108]
- IPR023737: Spermidine export protein MdtI (family) [1-109]
- IPR045324: Small multidrug resistance protein (family) [6-99]
- IPR000390: Small drug/metabolite transporter protein family (family) [4-108]
Interaction partners: - Spermidine export protein MdtJ
- Spermidine export protein MdtJ
- Spermidine export protein MdtJ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0140352 (export from cell), GO:0009410 (response to xenobiotic stimulus), GO:0051716 (cellular response to stimulus), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0009892 (negative regulation of metabolic process), GO:0009991 (response to extracellular stimulus), GO:0009266 (response to temperature stimulus), GO:0104004 (cellular response to environmental stimulus), GO:1903825 (organic acid transmembrane transport), GO:0098739 (import across plasma membrane), GO:0042594 (response to starvation), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0006810 (transport), GO:0009636 (response to toxic substance), GO:0140115 (export across plasma membrane), GO:0031668 (cellular response to extracellular stimulus), GO:0009268 (response to pH), GO:0071496 (cellular response to external stimulus), GO:0009409 (response to cold), GO:0034219 (carbohydrate transmembrane transport), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009416 (response to light stimulus), GO:0043086 (negative regulation of catalytic activity), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:0006974 (cellular response to DNA damage stimulus), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0051180 (vitamin transport), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:0071702 (organic substance transport), GO:0010447 (response to acidic pH), GO:1905039 (carboxylic acid transmembrane transport), GO:0031669 (cellular response to nutrient levels), GO:0071467 (cellular response to pH), GO:0071468 (cellular response to acidic pH), GO:0009411 (response to UV), GO:0015695 (organic cation transport), GO:0003333 (amino acid transmembrane transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0071482 (cellular response to light stimulus), GO:0046942 (carboxylic acid transport)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:1990961 (xenobiotic detoxification by transmembrane export across the plasma membrane), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0140352 (export from cell), GO:0140115 (export across plasma membrane), GO:0009636 (response to toxic substance), GO:0006810 (transport), GO:0046618 (xenobiotic export from cell), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0042908 (xenobiotic transport), GO:0015695 (organic cation transport), GO:0015846 (polyamine transport), GO:0015848 (spermidine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane)