Protein: Inactive glycosyltransferase 25 family member 3 (Cerebral endothelial cell adhesion molecule) (Q5T4B2)
Organism: Homo sapiens (Human)
Function: Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
Sequence: MRAARAAPLLQLLLLLGPWLEAAGVAESPLPAVVLAILARNAEHSLPHYLGALERLDYPRARMALWCATDHNVDNTTEMLQEWLAAVGDDYAAVVWRPEGEPRFYPDEEGPKHWTKERHQFLMELKQEALTFARNWGADYILFADTDNILTNNQTLRLLMGQGLPVVAPMLDSQTYYSNFWCGITPQGYYRRTAEYFPTKNRQRRGCFRVPMVHSTFLASLRAEGADQLAFYPPHPNYTWPFDDIIVFAYACQAAGVSVHVCNEHRYGYMNVPVKSHQGLEDERVNFIHLILEALVDGPRMQASAHVTRPSKRPSKIGFDEVFVISLARRPDRRERMLASLWEMEISGRVVDAVDGWMLNSSAIRNLGVDLLPGYQDPYSGRTLTKGEVGCFLSHYSIWEEVVARGLARVLVFEDDVRFESNFRGRLERLMEDVEAEKLSWDLIYLGRKQVNPEKETAVEGLPGLVVAGYSYWTLAYALRLAGARKLLASQPLRRMLPVDEFLPIMFDQHPNEQYKAHFWPRDLVAFSAQPLLAAPTHYAGDAEWLSDTETSSPWDDDSGRLISWSGSQKTLRSPRLDLTGSSGHSLQPQPRDEL
InterPro domains: - IPR002654: Glycosyl transferase, family 25 (family) [320-503]
- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [20-272]
- IPR050757: Collagen-modifying Glycosyltransferase 25 (family) [29-576]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0035250 (UDP-galactosyltransferase activity), GO:0008378 (galactosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:1903055 (positive regulation of extracellular matrix organization), GO:1902903 (regulation of supramolecular fiber organization), GO:1903053 (regulation of extracellular matrix organization), GO:0045229 (external encapsulating structure organization), GO:0043062 (extracellular structure organization), GO:0097435 (supramolecular fiber organization), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0030199 (collagen fibril organization), GO:0030198 (extracellular matrix organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen)