Protein: NLR family, CARD domain-containing 5 (K7DYB6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MRMERMDWSGDALTLVAQEASVLVDLLCEQDSSVLDHIFDLLESNTQDEIRSLINNRDRVSAIVDYFKTSDNITCRKFFCTIYEYCKDIPFYLETTLVSIAGDPIDNYSSSRNVKRLRLDPLQSYTDALKSMVKEKHKTVMQSVVKDIRLDDTWVYLKHRNPPRAKDRTLQLQASLDSHEGEESEHKVSVESLLKTTGRVVVLLGQAGSGKTLLVHCLGHSWAENTFPSIQLLFLLEFRQLNLISRDLSLKELLFLFYPACSYVEEEKEEVFAFILTHPDKVCFILDGYDEFRAKLTDPRELESTVDLSTPMPMADLLSGLCSRKILPDCTVLVTCRPRDVTDMFGSPGLITCELQGFDRLGVKEYAEQYFHEKGDLKTNAVNLLMDNRHLLSMSHVPGLCHICCICVDHLFSSGEVLNHQLPTSLTQIYIQILLAFLSRFNEDGVSKTSLLMRYRTKIVEMSQLALKGLEGSTIVFMETEVSKELQDFGVRSGILSRVKLTHEDGSSGYGFTFMHLTMQEFLAALHLMTSQTITDGQLKKKLNLKTRWTTKTDPKSVFTDSVHLYVCGLAAEACTSCLVQLKGAESETTWVKKRQAAVRNVLLGLAGGASHTGPKIVELCRCAHETQDAKLAKAIGSRPQIELRNIRLNAVDMDSLAFVTAAADQTVCLDFGGCSIDLDCLEILPSFKNVDHLIFRSRKYDDKFAETLCGILSKLQALQQLDFISGGLTDVGAAKLAKALEDCPNITHLNVSDNSLKDEGIREIAETVSRLHNISSILMGKNNISTDGILTLIERMAACTSVQEVHVEGNKEINLSFSKRSDTISESKDLKNTEETKNIILKQCNLTVSHVASLCNKLRGFAILTLLDLSNNSLGNKGLKKILDLLPKLGGIQEINVSENGVDMEGVVMLASALCKQYNLKRVDASENGKKKVVLGFDTTRGHNSGELTQNETGMQLHKKLSLTHSDIQPAYMTKLCKQLVKCKNLLDIDFSNLKLTDDSVENLMLILPVMLSLHVLNLSHVDLSTNGALILVRSLADCQRVTSVELRHQAEAFIKFVPEKAEVAICKLTEYNLSKTNVVKLSKILESCPHLSELDLSHNVLRDEGVKCFVDHLPKLKISSSVSLIGNRMTQIGALHLVNSMNTCEKVVAVEVSLGVEDQSLIQFVQEHANGKTLRLRECSFELAHLKMLVKILTKCPRLLSLELSSNSLNSQGLFSLLDSLAELSTIQTLTLRNNGLNSEQIEHFVKQFSHCNQHRDIRIEESWMTGSAAIGLIARCLSLQQHIREIRVHRASINMIIEANSISSSTSVGHSENVLPALQSISFDDCDVEGQHLTQLALPIQKCHALLDLKFSPLKLDRIGAEFFSAVIPFLRNLRNITLDLKGAAEEEVETLAEALPNTPAFESLSLSQLVLSDRGATLFGKAFQNVPNLKSFSMLQCSGWTAARGCDLVRGLMQCVLLTEIRLESVVLDQEGINILAQGLSRLASLRRLSLNNITVVTSETFVNGTGILCLLASFKGFKQMEEIELESWRMGDGGTNELVKYIPSWTGLVKISLSENIVTDQAGEKLLTALSHCRALQQLKLSKNKLGQASAAKLAKILPLLPQLSELNLSENQFGPQGSSVLCEGLVSMKALKKLHLTSVESSDLVGVASSLKHCPSIEDVSLSWNGCGDSLARTLAEILPLCTKLKRLDLEANNITTAGATLIAKCLPLCPSIEVIRLWRNSIAKDDENLKDPKLNFSSV
InterPro domains: - IPR041267: NACHT, LRR and PYD domains-containing protein, helical domain HD2 (domain) [516-634]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [122-371]
- IPR001611: Leucine-rich repeat (repeat) [744-1710]
- IPR006553: Leucine-rich repeat, cysteine-containing subtype (repeat) [744-1712]
- IPR007111: NACHT nucleoside triphosphatase (domain) [199-373]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [641-1745]
Interaction partners: - NLR family member X1
- IkappaB kinase
- DNA-binding protein RFXANK
- NACHT and WD repeat domain-containing 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha
- Caspase a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0002682 (regulation of immune system process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0060759 (regulation of response to cytokine stimulus), GO:0050777 (negative regulation of immune response), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0044092 (negative regulation of molecular function), GO:0009617 (response to bacterium), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006952 (defense response), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0031323 (regulation of cellular metabolic process), GO:0060761 (negative regulation of response to cytokine stimulus), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0031348 (negative regulation of defense response), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0045088 (regulation of innate immune response), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0045824 (negative regulation of innate immune response), GO:0001960 (negative regulation of cytokine-mediated signaling pathway), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:0060339 (negative regulation of type I interferon-mediated signaling pathway), GO:2001141 (regulation of RNA biosynthetic process), GO:0060338 (regulation of type I interferon-mediated signaling pathway), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)