Protein: Integrin alpha-11 (Q9UKX5)
Organism: Homo sapiens (Human)
Function: Integrin alpha-11/beta-1 is a receptor for collagen.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGAPLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKNHGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNLFVYNGTLKDSHSYQNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATGLQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAVLLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [781-940]
- IPR002035: von Willebrand factor, type A (domain) [162-350]
- IPR000413: Integrin alpha chain (family) [422-1171]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [635-759]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [23-637]
- IPR013517: FG-GAP repeat (repeat) [480-577]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [637-1145]
- IPR013519: Integrin alpha beta-propellor (repeat) [24-654]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [159-353]
Interaction partners: - Integrin beta-1
- Integrin beta-5
- Integrin beta-3
- Integrin beta-8
- Integrin beta-7
- Integrin beta-6
- Integrin alpha-5
- Integrin alpha-2
- Integrin alpha-10
- Integrin alpha-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0005518 (collagen binding), GO:0019902 (phosphatase binding), GO:0098631 (cell adhesion mediator activity), GO:0019903 (protein phosphatase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0007158 (neuron cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0098636 (protein complex involved in cell adhesion), GO:0098797 (plasma membrane protein complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0008305 (integrin complex), GO:0005886 (plasma membrane)