Protein: Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (Leucine zipper protein 5) (More than blood protein) (Non-SMC condensin II complex subunit G2) (Q6DFV1)
Organism: Mus musculus (Mouse)
Function: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst.
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MEKREAFIQAVSKELVEEFLQFLQLDKDSSNPFSLSELLDELSRKQKEELWQRLKDLLTETLLESPVDRWQTVEVEGADDMESEHSPKMRKSIKIICAIVTVILASVSIINEHENYGALLECAVILNGILYALPESEQKLQNSIQDLCVKWWERGLPAKEDMGKTAFIMLLRRSLETKSGADVCRLWRIHQALYCFDYDWEESREIKDMLLECFINVNYIKKEEGRRFLSFLFSWNVDFIKMIHETIKNQLAGLQKSLMVHIAEIYFRAWKKASGKMLETIEYDCIQDFMFHGIHLLRRSPVHSKVREVLSYFHQQKVRQGVEEMLYRLYKPILWRGLKARNSEVRSNAALLFVEAFPIRDPNFTATEMDNEIQKQFEELYNLIEDPYPRVRSTGILGVCKISSKYWEMMPPNILVDFLKKVTGELAFDISSADVRCSVFKCLPIILDNKLSHPLLEQLLPTLRYSLHDNSEKVRVAFVDLLLKIKAVRAAKFWKICPMEDILVRLEMDSRPVSRRLVSLIFNSFLPVNQPEEVWCERCVTLIQMNRAAARRFYQYAHEHTASTNIAKLIHVIRHCLNACIQRTLREGSEAHKECEKENASVLDKTLSVNDTASMAGLLEIIVILWKNIHRSLENNKEAKIYTINKFAAVLPEYLKVFKDERCKIPLFMLMSFLPASAVPVFSCGVISVLRNQESVTGRSYCTLLDCLCSWGQVGHVLELIVDWLPTVPPQAKSNLASKRKVEINDTCSVKPELALLYMEYLLTHPKNRECLLSVPQKKLNQLLKALEGSKAELESFLQSPSGNPLNFNKATALHAFGLYCRMSVHLQYKFCSEEKIHLSILDDTGSWLENKVLPLLEDQEEEYLKLRKDVYQQIIQTYLAVCKDVVMVGLGDPKFQMQLLQRSFGIMKTVKGFFYVSLLLGILKEIAGNTIIHKTDSDEKVTVLFDLVQEVFQKMLECIACIFRKQPEESLPLFHSVQTPLHEFITTIQSWHKDTAVHHAVLSTLIAAPVVEISHQLQKVSDIEELTSPQCLHDLPPFSRCLVGVIMKSSDVVRSFVDELKACVTSGDVEGIVCLTAVLHIILVINKGKHISAKVKEVATAVYRKLKTFMEITLEEDSLERFLYESSMRTLGEFLNP
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [9-987]
- IPR024741: Condensin-2 complex subunit G2 (family) [212-361]
- IPR011989: Armadillo-like helical (homologous_superfamily) [299-553]
Interaction partners: - Condensin-2 complex subunit D3
- Condensin-2 complex subunit H2
- Structural maintenance of chromosomes protein 4
- Condensin complex subunit 1
- Structural maintenance of chromosomes protein 2
- Condensin complex subunit 2
- Non-SMC condensin I complex, subunit G
- Serine/threonine-protein kinase PLK1
- Kinetochore protein Nuf2
- SHC SH2 domain-binding protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0061982 (meiosis I cell cycle process), GO:0007059 (chromosome segregation), GO:0140013 (meiotic nuclear division), GO:1903047 (mitotic cell cycle process), GO:0016043 (cellular component organization), GO:0045132 (meiotic chromosome segregation), GO:0007062 (sister chromatid cohesion), GO:0000278 (mitotic cell cycle), GO:0045143 (homologous chromosome segregation), GO:0098813 (nuclear chromosome segregation), GO:0140014 (mitotic nuclear division), GO:0007064 (mitotic sister chromatid cohesion), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0007127 (meiosis I), GO:0000819 (sister chromatid segregation), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)