Protein: Tusp, isoform F (A0A0B4KI44)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MHLHFERNINTKCDCTILSLSWMGKVPDDIPEDEGWKLNRTNYYQEGWLATGNVRGIVGVTFTTSHCRKNMDYPLRTNYNLRGHRSDVILVKWNEPYQKLASCDSSGIIFVWIKYEGRWSIELINDRNTPVTHFSWSHDGRMALICYQDGFVLVGSVAGQRYWSSMLNLESTITCGIWTPDDQQVYFGTTQGQVIVMDVHGAMVSQVQLSNDVPITSMAWSCEKFKMEEGEEAEPGVTNAAKRSFVLAVSFQNGYIYLLKSFDDVSPAHINTCLNGALGMVMEWSNSRELLAVAGTLRTGVDGTKTEDMGTPSCYTNLVKFYTETGTCLYQAHIPCSSATVSAITWGHNDKRLFIATGTQVHIAWVSRRVASLQLLCRLEIQASVGSESLLPLLPLPSRIKSLIGNLFAQTIRCCVPDLKSLRDFVSRPPLCSTRLHCTMIRHDDDSNLSSGTCYTLYLEYLGGLVPLLKGKRTSKIRPEFVIFDPQVNDSPLYFQYSAEAKSSSGSSQSTTTGNSGRTDSSDSDFEERSRFGSPRTPRKKRVRPKRRHQAGDRLSASGGGVSNDPDSLDELAYVDTLPEQEVKLVEVTSNIWGTKFKIHGLAKTVPANLGQVTYKTSLLHLQPRQMTLVITELRDDFPPGPDPSFNPNIFSEDEDEHHQHQGIHHDAVPQVNVITAQDGASLKPPIIPQRRLTDGASAPLIAPMSPRPNRILARHKNSLTVNGERGSGSSAGLSPLARAESYDDDSSNESQEAGAAGSQSTTVLLHQAPSNGSGPGPSCSKSITRPKTISSFKNSYSRSSSNSSCQSRHAISPLYCDGAVPTLQSPKNAVAPSDIIFERPAVPAAGQTTLMSYSSNADYANNVVQVKNALMSEPVRSANSHVNPVPLNLNLNLERMDARVKCTAPTTSSTAKRREMLYIDEETQSPTPTPSSSSMKRTPTVVSIAPALPDSITRSCSVGYLDSVAITPSDEALSALRKDAPNKRLILVDKKRNRRKRQQQEDARRHKLQQTGKSKSLDSCDLLSLQTKLSSKEHEQVVRKLQEISDSSACSSAANTLCFKCRNNMSPSSACKRCQPSASSVLDEITAVVPAVEPAKESPAVQAKPAPKKRFDVITSFTDSPLFTRKHRFGIGRSKETAGTENSTPLLGRKQDNGFSFVKQLSEVRWRRKEQPAQAQVNGSSNASTLERQPQPEITGAACGTVEATPVEAKASVSLHTQALTTLENIISRLRDLDEGRLTPPSTPQRLPRSSPASPAASKKNKRQQSNSPIRHILNSPLLNRRQRKKQSIIESSDDEGNQTNGSGEESNNAGNGKQYRDLETFQKAQLRQKLKRGKIEPNGSASCANPAPVRREFVMHNKAPMWNEMSQVYQLDFGGRVTQESAKNFQIEFRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALANVTQRLK
InterPro domains: - IPR025659: Tubby-like, C-terminal (homologous_superfamily) [577-1432]
- IPR001680: WD40 repeat (repeat) [81-112]
- IPR036036: SOCS box-like domain superfamily (homologous_superfamily) [362-402]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [76-361]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [67-373]
- IPR000007: Tubby, C-terminal (domain) [1267-1427]
- IPR056159: IFT121/TULP4, N-terminal (domain) [45-365]
- IPR001496: SOCS box domain (domain) [360-410]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045879 (negative regulation of smoothened signaling pathway), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0008589 (regulation of smoothened signaling pathway), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)