Protein: Testis-specific Y-encoded protein 1 (Cancer/testis antigen 78) (CT78) (Q01534)
Organism: Homo sapiens (Human)
Function: May be involved in sperm differentiation and proliferation.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8923009}. Nucleus {ECO:0000269|PubMed:8923009}. Note=Predominantly cytoplasmic. Also found in nucleus.
Sequence: MRPEGSLTYRVPERLRQGFCGVGRAAQALVCASAKEGTAFRMEAVQEGAAGVESEQAALGEEAVLLLDDIMAEVEVVAEEEGLVERREEAQRAQQAVPGPGPMTPESAPEELLAVQVELEPVNAQARKAFSRQREKMERRRKPHLDRRGAVIQSVPGFWANVIANHPQMSALITDEDEDMLSYMVSLEVGEEKHPVHLCKIMLFFRSNPYFQNKVITKEYLVNITEYRASHSTPIEWYPDYEVEAYRRRHHNSSLNFFNWFSDHNFAGSNKIAEILCKDLWRNPLQYYKRMKPPEEGTETSGDSQLLS
InterPro domains: - IPR002164: Nucleosome assembly protein (NAP) (family) [99-289]
- IPR037231: NAP-like superfamily (homologous_superfamily) [86-288]
Interaction partners: - Amelogenin, Y isoform
- Amelogenin, X isoform
- Putative serine/threonine-protein kinase PRKY
- Protocadherin 11 Y-linked
- RNA-binding motif protein, Y chromosome, family 1 member A1
- F-box-like/WD repeat-containing protein TBL1Y
- Deleted in azoospermia protein 1
- Sex-determining region Y protein
- Protocadherin-11 X-linked
- Heat shock transcription factor, Y-linked
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0009314 (response to radiation), GO:0071214 (cellular response to abiotic stimulus), GO:0009966 (regulation of signal transduction), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0008284 (positive regulation of cell population proliferation), GO:0071478 (cellular response to radiation), GO:0051246 (regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0010212 (response to ionizing radiation), GO:1902531 (regulation of intracellular signal transduction), GO:0051896 (regulation of protein kinase B signaling), GO:0031399 (regulation of protein modification process), GO:0071479 (cellular response to ionizing radiation), GO:0051897 (positive regulation of protein kinase B signaling), GO:0031401 (positive regulation of protein modification process), GO:0010332 (response to gamma radiation), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0071480 (cellular response to gamma radiation), GO:0031396 (regulation of protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)