Protein: Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) (P16036)
Organism: Rattus norvegicus (Rat)
Function: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:2250020}; Multi-pass membrane protein {ECO:0000269|PubMed:2250020}.
Sequence: MFSSVAHLARANPFNAPHLQLVHDVSGPRSPPGPPRRSRHLAAAAVEGYSCEFGSMKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSITLKEDGVRGLAKGWAPTLIGYSMQGLCKFGFYEVFKALYSNILGEENTYLWRTSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLREAVPKMYKEEGLNAFYKGVAPVWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECTKAEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSTASQVLQRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTE
InterPro domains: - IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [57-334]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [56-334]
- IPR044677: Mitochondrial phosphate carrier protein SLC25A3/Pic2/Mir1-like (family) [43-345]
Interaction partners: - Cytochrome b-c1 complex subunit Rieske, mitochondrial
- ATP synthase F
- E3 ubiquitin-protein ligase RING1
- ATP synthase F
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit 5A, mitochondrial
- Chromobox 1
- Uncharacterized protein
- BMI1 proto-oncogene, polycomb ring finger.
- Non-selective voltage-gated ion channel VDAC2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0044877 (protein-containing complex binding), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015295 (solute:proton symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0006817 (phosphate ion transport), GO:0035435 (phosphate ion transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0043209 (myelin sheath), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)