Protein: Cytochrome b5 domain-containing protein 1 (Q567I9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Radial spoke stalk protein that binds heme under oxidizing conditions (Probable). Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme. Note=Localizes to the radial spoke stalk
Sequence: MRRSKYFTPNEVSLHNTINDIWVSYLGKVYDLTPLLEAYKGDVLLKPIIECAGKDISHWFDPKTKDILTHVDPLTGCIKYYTPRGRFIHIPPPCPRTDWANNFGKPWWKDNRYEVGLLSAKTRWIRIINTLTSQEQKLEVCSEESLDEILHRYLFYNSHAASYTWKLSGINLDMSKTLSENGIPEEDEFYCGSPDCNLFSPSICLYFNDDLTEL
InterPro domains: - IPR052320: Cytochrome b5 domain-containing (family) [2-213]
- IPR036400: Cytochrome b5-like heme/steroid binding domain superfamily (homologous_superfamily) [1-99]
- IPR001199: Cytochrome b5-like heme/steroid binding domain (domain) [4-79]
Interaction partners: - Intelectin 2
- Cilia and flagella-associated protein 58
- Cytochrome b5 reductase 4
- Axonemal dynein light intermediate polypeptide 1
- Sulfite oxidase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0003676 (nucleic acid binding), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0003723 (RNA binding), GO:0016717 (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0043207 (response to external biotic stimulus), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0009790 (embryo development), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0042742 (defense response to bacterium), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0048925 (lateral line system development), GO:0043009 (chordate embryonic development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0014032 (neural crest cell development), GO:0048884 (neuromast development), GO:0150063 (visual system development), GO:0048706 (embryonic skeletal system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)