Protein: Beta-1,4-galactosyltransferase (Q6DRL9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts
Subcellular location: Golgi apparatus membrane; Single- pass type II membrane protein
Sequence: MMYSSRRKPVLYFKDERSFLSRKCTVWKLFGLCMVFVFGSLLWVQLTCTGDMSQTAGYSHLPQQPCPIDKQSSHVDDPSWGPHKMALIVPFRERFEELLVFVPYMHAFLNKKKIRHKIFIINQVDHFRFNRASLINVGFMESGNDTDYIAMHDVDLLPQNEDLNYGFPVDGPFHVASPELHPLYHYKTYVGGILLLTKKHYLACNGMSNRFWGWGRENDEFFRRLKAANLELFRPTGITTGTKTFRHIHDPAWRKRDQKRIAAQKQEQFKVDPEGGLSNLRYKVESRKEVSISGAPCTVINTFVECDLNQTPWCQFS
InterPro domains: - IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [54-317]
- IPR027995: Galactosyltransferase, N-terminal (domain) [81-165]
- IPR027791: Galactosyltransferase, C-terminal (domain) [172-247]
- IPR003859: Beta-1,4-galactosyltransferase (family) [79-315]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016757 (glycosyltransferase activity), GO:0140103 (catalytic activity, acting on a glycoprotein), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0035250 (UDP-galactosyltransferase activity), GO:0008378 (galactosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0044249 (cellular biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0009100 (glycoprotein metabolic process), GO:0048732 (gland development), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0060429 (epithelium development), GO:0061008 (hepaticobiliary system development), GO:0006029 (proteoglycan metabolic process), GO:0001889 (liver development), GO:0009101 (glycoprotein biosynthetic process), GO:0006493 (protein O-linked glycosylation), GO:0030166 (proteoglycan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)