Protein: DNA helicase (Q8T145)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGDKYLNSKKNSSGFSFLNKPVNDNPFVRNESANPFGNGAINQSPLNPFKKASPFKQQQPQPIQRQQQQQQQQQQQQQQPQQQQQQQPFQPFQYQSPKKIQNPNVPISLPQPINNNSTTTTTTSNTPYKSPQTIQQQQQQQQQNVNNIKNTSPYRQQTEQQQSVYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINNPIEIELDDFELSFSDDILNKNSGESSSAPKDMEVDSSNSSSSGTTNVNNNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKPIIIEDMDFDIDFEFDIDTNVEITGSSNVINSTAAKTSTTTTTTTTTASTTIPSATSILKNSTTSNTSTTTTATTKPPIINLDTISPPLQQQQKLNVTLPILKTPQINKPLQPSLPTKPPIKNNTTLPTTNKSPTTTTTTTKFIDKFKGMKRYTKDLPEGFEISSENQEPYRNEKMIGEFLYPEDNIREYQFKFIQSAFLENTMICLPTGLGKTFIASILMLNYYHWFPKSKLVFLVHTKSLVSQQIEAFHRDTGIPKSDSIQFTGDTTSKLKRQSLWNSKRVFFSTPQILANDIGSGNCDPRSICCIVIDEAHRAQGNYDYCVAIKLILKVNRFFRVLALTATPGSNNAAIQKVINNLLISNMELRSEDSADIKPYIHSKKTDVLSIALSDDYKSIIKDYEFFIVDKLKVLFEFNILNPTTTPDRVSHSFILEKIKSIQFSNSPVYGSGGNKFKLLRALVTLQTLYQGYALLKVHGLESFYDKISNLEDASSKTIKAFSKNENWKQFIIKIKKSIDNGLVHDKLIKLNDVLIEHFQSNNPRSSKVMIFVQFRRSVQEIIDFISNNNNGGGGGGKSLIKVMPFYGQSATDKGVKGIHKKEQQAILNSFVNGDINVLVSTCIGEEGLDIGEVDLVVCYDVQQSSLKNTQRTGRTGRKRDGRCIFLITQGYEEYIYEKSQSNLDSLSNLKESSFVFHYSPKMIDSIPLVKYIKINENNIYSNDDNDIELNDGGGDYYEDDDSLFENNKKSTTSRGVKNSKNYLADDQIRYMQLNHNVVNHKTNFNYKEILSKNSHLNSISTDIEDIKHSDKTNILISISKSIDAIKYSSDYTDLSKMPDIVKKVVSEMPLDNNDNDNDGIGLAYDDSPRDYGYDRYEPFTTSTTTTAIGTSIPTTATTSTTINSTSYSTSTSTSTNTNTKTTLPSTSTINKISPPPQQKQPIISTSSINQSMKTNPIIISNNTVLSNLNNSLGNNFIPFVRKVKQPEHKKVYEIPNLPPDEELIFDFSKILLRENNENEKIITTNDYINTQNQPQPQQPTPTPTPPPPSTPNLTPIKKTISPTPTPTPQISKPFPLSPTPPTPTPPPPIVSNPLPSFQQKQQQQQQQIYISPTPTPPPPQISKPLPLSPVSKPLPLSPVSKPISIQLTPIQPPQKTTPTTPDLTPVKRRKPKNLFDKFDDNDEGDDAVIFENNNLNNIINLKNNNNNNNNNNNNNNNNNNNNNNNNNNNTIVLEKVDKKSIFNLDDIDNNLFTFGLTQQQTQQQFQKKNRDRYRFGDRDKNIDSYGNDKFFEDSEAEEDSEIERRNSQDDDDDDDEEEDGIGENKYDLHDSFINDGDESAENSLSSQSTTPTKKKKKNKRKRKSNNFIYAQSLLSQNSLGFNGGSKRKGGLLSVIEKFEKIGQHEEEFIDENDYTGSEDYDDENENENDYESGSDSIEEIDKSINSSEEKRQKKYHHHNNNNNNPKLSSIHSKPIIDSPKSNNSNNNNSNSKNRKDFSNHDLFSL
InterPro domains: - IPR006935: Helicase/UvrB, N-terminal (domain) [474-631]
- IPR044749: FANCM, DEAH-box helicase domain (domain) [473-653]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [470-974]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [469-667]
- IPR001650: Helicase, C-terminal domain-like (domain) [813-991]
- IPR039686: FANCM/Mph1-like, insert domain (domain) [681-795]
Interaction partners: - DNA 3'-5' helicase
- RecQ-like DNA helicase BLM
- DNA excision repair protein ERCC-1
- ATP-dependent DNA helicase
- Probable crossover junction endonuclease mus81
- Replication protein A subunit
- RING-type domain-containing protein
- DNA polymerase zeta catalytic subunit
- Nuclear protein localization protein 4 homolog
- DNA topoisomerase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)