Protein: Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) (Q13303)
Organism: Homo sapiens (Human)
Function: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes KCNA4 channel closure. Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.
Sequence: MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS
InterPro domains: - IPR036812: NAD(P)-dependent oxidoreductase domain superfamily (homologous_superfamily) [36-361]
- IPR023210: NADP-dependent oxidoreductase domain (domain) [52-354]
- IPR005399: Potassium channel, voltage-dependent, beta subunit, KCNAB-related (family) [27-367]
- IPR005401: Potassium channel, voltage-dependent, beta subunit, KCNAB2 (family) [1-353]
- IPR005983: Potassium channel, voltage-dependent, beta subunit, KCNAB (family) [39-355]
Interaction partners: - Potassium voltage-gated channel subfamily A member 2
- Potassium voltage-gated channel subfamily A member 1
- Potassium voltage-gated channel subfamily A member 3
- Potassium voltage-gated channel subfamily A member 4
- Potassium voltage-gated channel subfamily A member 5
- Potassium voltage-gated channel subfamily A member 6
- Voltage-gated potassium channel KCNC1
- A-type voltage-gated potassium channel KCND2
- 2-Hydroxyacid oxidase 1
- Voltage-gated potassium channel KCNC4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:0019897 (extrinsic component of plasma membrane), GO:1902495 (transmembrane transporter complex), GO:0098562 (cytoplasmic side of membrane), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0034702 (ion channel complex), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)