Protein: Rho GDP-dissociation inhibitor 1 (AtRhoGDI1) (Rho GDI-1) (Q9SFC6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MSLVSGARDMGFDDNNNNKNNKDGDDENSSSRTRADDDALSRQMSESSLCATEEEEDDDSKLQLGPQYTIKEHLEKDKDDESLRKWKEQLLGSVDVTNIGETLDPEVRIDSLAIISPGRPDIVLLVPENGNPKGMWFTLKEGSKYNLKFTFHVNNNIVSGLRYTNTVWKTGVKVDRAKEMLGTFSPQLEPYNHVMPEETTPSGMFARGSYSARTKFLDDDNKCYLEINYSFDIRKEWPAL
InterPro domains: - IPR024792: Rho GDP-dissociation inhibitor domain superfamily (homologous_superfamily) [59-239]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [50-238]
- IPR000406: Rho protein GDP-dissociation inhibitor (family) [41-238]
Interaction partners: - Rac-like GTP-binding protein ARAC4
- Rac-like GTP-binding protein ARAC5
- Rac-like GTP-binding protein ARAC11
- Rac-like GTP-binding protein ARAC3
- Rac-like GTP-binding protein ARAC8
- Rac-like GTP-binding protein ARAC10
- Rac-like GTP-binding protein ARAC6
- Rac-like GTP-binding protein ARAC7
- Guanosine nucleotide diphosphate dissociation inhibitor 2
- Ras-related protein RABB1a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005092 (GDP-dissociation inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0050794 (regulation of cellular process), GO:0009991 (response to extracellular stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels), GO:1902531 (regulation of intracellular signal transduction), GO:0034198 (cellular response to amino acid starvation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)