Protein: G2/mitotic-specific cyclin-A (P14785)
Organism: Drosophila melanogaster (Fruit fly)
Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the Cdk1 and Cdk2 protein kinases to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.
Sequence: MASFQIHQDMSNKENPGIKIPAGVKNTKQPLAVIGGKAEKNALAPRANFAVLNGNNNVPRPAGKVQVFRDVRNLNVDENVEYGAKKSNVVPVVEQFKTFSVYEDNNDTQVAPSGKSLASLVDKENHDVKFGAGQKELVDYDLDSTPMSVTDVQSPMSVDRSILGVIQSSDISVGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISHNMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPPEVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISELSLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKELNTQAMREKYNRDTYKKVAMMESVEMSKDDFDQLCEAYNCKQKEDEHQQPDINTKSNVNLFYKF
InterPro domains: - IPR048258: Cyclins, cyclin-box (conserved_site) [236-267]
- IPR004367: Cyclin, C-terminal domain (domain) [334-451]
- IPR013763: Cyclin-like domain (domain) [241-420]
- IPR039361: Cyclin (family) [170-439]
- IPR006671: Cyclin, N-terminal (domain) [206-332]
- IPR036915: Cyclin-like superfamily (homologous_superfamily) [197-452]
Interaction partners: - Cyclin-dependent kinase 2
- Cyclin-dependent kinase 1
- Cell division control protein
- Dacapo
- Cell division cycle protein 20 homolog
- cyclin-dependent kinase
- S-phase kinase-associated protein 2
- Cyclin-dependent kinases regulatory subunit
- Double parked, isoform A
- Fizzy-related protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016538 (cyclin-dependent protein serine/threonine kinase regulator activity), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0007017 (microtubule-based process), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0007059 (chromosome segregation), GO:0090068 (positive regulation of cell cycle process), GO:1903047 (mitotic cell cycle process), GO:0007051 (spindle organization), GO:0044770 (cell cycle phase transition), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0000226 (microtubule cytoskeleton organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0007098 (centrosome cycle), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0045787 (positive regulation of cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0044772 (mitotic cell cycle phase transition), GO:0051983 (regulation of chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:1901989 (positive regulation of cell cycle phase transition), GO:0044843 (cell cycle G1/S phase transition), GO:0051246 (regulation of protein metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0033043 (regulation of organelle organization), GO:0007052 (mitotic spindle organization), GO:0051338 (regulation of transferase activity), GO:0006996 (organelle organization), GO:0045931 (positive regulation of mitotic cell cycle), GO:0051174 (regulation of phosphorus metabolic process), GO:0007010 (cytoskeleton organization), GO:0051783 (regulation of nuclear division), GO:0043549 (regulation of kinase activity), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0033045 (regulation of sister chromatid segregation), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:1902751 (positive regulation of cell cycle G2/M phase transition), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0030071 (regulation of mitotic metaphase/anaphase transition), GO:0071900 (regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0019908 (nuclear cyclin-dependent protein kinase holoenzyme complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:1902911 (protein kinase complex), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:1902554 (serine/threonine protein kinase complex), GO:0000794 (condensed nuclear chromosome)