Protein: Rho guanine nucleotide exchange factor (GEF) 12a (A0A2R8QD00)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Membrane
Sequence: MSDTRSTVSDRTSSFLSRDHPPDKRPKSDKLPGTPTHEFDPTGLVQRCVIIQKDENGFGLTVSGDNPVFVQLVKQDGAAMRAGVQTGDRIIKVNGTLVTQSNHVEVVKLIKSGSYVALTVLGRPPGLPQIPLPEVDVGLESPDVFGDPFITSPNSYNAAERTSSPLVSWEENSALHNQRMDSRRTGLKDQQDTQESPCLRNSEDGSWAEEDQYKRDFSPEAFWSGNSVPSVHRRFYPASPESQRDSNCSSPKSTPRDSFNSCPSPEVDYGSDLDSRFPSTVGSPRLVSEIIAAEDDDFDSEQEQVNGQCSCFQSIQLLKTRPAHLAAFLHHVISQFDPAPLLCYLYADLYKQTNSKETRRIFTDFLTFFIDRGANLKVTVPESISSELERRRPELIPEELHRQYIQTMQETLFPDVQRNLEDFRQKRSMGLTLADTELSRLDSEQLAVDRERACAESILSKIDDVLLTSQPTEEEKCSTIQYVIFMYMKHLGVRAKEQRNLESKRVRINFLPSKLRKSKTEKDGEEKLKKSRFPIRVPPRWPGRLDSVPSGRVGDSIKQRPQKQMSQPALGGSELIDAGRLRGSQSSEGSDLLHSPGLITSSPFSAPYSSPSDPSGRDSEFNMSPSAVVPRLSDGLQSGDPLDSIYPPCDYIPYNVDQLDEDRDGDRPPDVGTPKPSRRFEDLQSEDDQGSDVYSDVDPPNWQQLVGRDVLAGLTPHEIKRQEVINELFYTERAHVRMLKVLDKVFYQKLNRDNILPPADIKYIFTNLEEIIQLHVRIVDQMTAICKKNETSVIDHIGDELLSWFSSGEEEKIKQAVGTFCSNQPFALELIKSRQKKDQRFSSFMQEAESNRLCRRLQLKDIIPAEMQRFTKYPLLMDNIAKYTDESEEKDKVRRAAECCRQILNHVNQSVKESENKQRLEDYQRRLDLSSLKQSENPMISEFKNLDLTKRKMVHEGPLSWKINKDKTIELYTLLLEDILVLLQKQDERLILRCHSKNLAGTAETKHIFSPIIKLSTVLVRSVATDNRSFFVISMSKNGAQIYELMAQTVSEQRMWQRQITQRAEVMNTKPHSVIPLPQHDGDRDGVELSKFSKGSDRISTGSIQSAEKDGEFSPSAALRDCVPDTNPGEEDQVARAGRDASYQDSELLNGRETDSLSCSSKADEALKTLAALKQVLLTQLMAQDEGERLGRSAGSRLLRTTSLRTPVEHNSNRTPSRAQDYTSGDTGFYECPEDYAAYLVLEGFGGSGESSTDDDFQVGRKEPGLAHSCAADSGISLKFSSPSSGSTSRLSRQVLSHLRCLQANLNHLKEMETKYYNLLRQRPVGSAAEADESREKK
InterPro domains: - IPR001478: PDZ domain (domain) [48-125]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [930-1074]
- IPR000219: Dbl homology domain (domain) [720-910]
- IPR015212: Regulator of G protein signalling-like domain (domain) [308-494]
- IPR001849: Pleckstrin homology domain (domain) [952-1067]
- IPR036305: RGS domain superfamily (homologous_superfamily) [310-494]
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [289-499]
- IPR036034: PDZ superfamily (homologous_superfamily) [36-127]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [697-929]
- IPR041020: ARHGEF1-like, PH domain (domain) [938-1063]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009798 (axis specification), GO:0003002 (regionalization), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007166 (cell surface receptor signaling pathway), GO:0060914 (heart formation), GO:0007224 (smoothened signaling pathway), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071772 (response to BMP), GO:0010092 (specification of animal organ identity), GO:0072359 (circulatory system development), GO:0009953 (dorsal/ventral pattern formation), GO:0009950 (dorsal/ventral axis specification), GO:0007507 (heart development), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0003128 (heart field specification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)