Protein: Advillin (Peripheral nervous system villin-like protein) (Pervin) (Q9WU06)
Organism: Rattus norvegicus (Rat)
Function: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11849295}. Cell projection, neuron projection {ECO:0000269|PubMed:11849295}. Cell projection, axon {ECO:0000269|PubMed:11849295}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O75366}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O75366}. Note=In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. {ECO:0000250|UniProtKB:O75366}.
Sequence: MSLSSAFRTVTNDPGIITWRIEKMELVLVPLSAHGNFYEGDCYIILSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKRGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNQGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMTVLQNTLGRRSIIKPAVPDEVTDQQQKSTIMLYHVSDTTGQLSVTEVATRPLVQELLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKTFSIGKIAKIFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPCYILYIWQGRHASQDELAASAYQAVEVDQQFGGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNVEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLWTQAEHYLWYGKGSSGDERAMAKELAELLCDGDADTVAEGQEPPEFWDLLGGKAPYANDKRLQQETLDIQVRLFECSNKTGRFLVTEVTDFTQDDLSPGDVMLLDTWDQVFLWIGAEANATEKEGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITTDMKNATLSLNSSESGPKYYPVEVLLKSQDQELPEDVDPTKKENYLSERDFVSVFGITRGQFVSLPGWKQLQLKKEAGLF
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [2-731]
- IPR007122: Villin/Gelsolin (family) [6-807]
- IPR036180: Gelsolin-like domain superfamily (homologous_superfamily) [120-433]
- IPR003128: Villin headpiece (domain) [753-819]
- IPR007123: Gelsolin-like domain (domain) [24-704]
- IPR036886: Villin headpiece domain superfamily (homologous_superfamily) [741-819]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0030029 (actin filament-based process), GO:0048522 (positive regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:0044057 (regulation of system process), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0030036 (actin cytoskeleton organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:1902903 (regulation of supramolecular fiber organization), GO:0032233 (positive regulation of actin filament bundle assembly), GO:0032231 (regulation of actin filament bundle assembly), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0051493 (regulation of cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0110053 (regulation of actin filament organization), GO:0051492 (regulation of stress fiber assembly), GO:0008154 (actin polymerization or depolymerization), GO:0051127 (positive regulation of actin nucleation), GO:0051495 (positive regulation of cytoskeleton organization), GO:0051125 (regulation of actin nucleation), GO:0051258 (protein polymerization), GO:0030041 (actin filament polymerization), GO:0034315 (regulation of Arp2/3 complex-mediated actin nucleation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0032433 (filopodium tip), GO:0042995 (cell projection), GO:0098862 (cluster of actin-based cell projections), GO:0005903 (brush border), GO:0030027 (lamellipodium), GO:0120025 (plasma membrane bounded cell projection), GO:0098858 (actin-based cell projection), GO:0030175 (filopodium), GO:0005902 (microvillus)