Protein: Mitochondrial import receptor subunit TOM40 homolog (Mitochondrial outer membrane protein of 38 kDa) (OM38) (Translocase of outer membrane 40 kDa subunit homolog) (Q75Q40)
Organism: Rattus norvegicus (Rat)
Function: Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (By similarity).
Subcellular location: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O96008}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with the mitochondria-associated ER membrane via interaction with BCAP31. {ECO:0000250|UniProtKB:O96008}.
Sequence: MGNVLAASSPPAGPPPPPTPSLVGLPPPPPSPPGFTLPPLGGGLGTGSNAGRGSERTPGAAASGAAASSNDGNCGCLPNPGTFEECHRKCKELFPVQMEGVKLTVNKGLSNRFQVTHTVALGTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLSPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEKGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSASFGYQLDLPKANFLFKGSVNSNWIVGATLEKKLPPLPLTLSLCAFLNHRKNKFLCGFGLTIG
InterPro domains: - IPR037930: Tom40 (family) [40-361]
- IPR023614: Porin domain superfamily (homologous_superfamily) [244-361]
- IPR027246: Eukaryotic porin/Tom40 (family) [79-354]
Interaction partners: - Mitochondrial import receptor subunit TOM70
- Mitochondrial import receptor subunit TOM22 homolog
- Translocase of outer mitochondrial membrane 5
- Mitochondrial import receptor subunit TOM7 homolog
- Mitochondrial import receptor subunit TOM20 homolog
- Translocase of outer mitochondrial membrane 6.
- Sorting and assembly machinery component 50 homolog
- Metaxin-1
- Metaxin
- Superoxide dismutase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0006839 (mitochondrial transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0006626 (protein targeting to mitochondrion), GO:0070585 (protein localization to mitochondrion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:0044232 (organelle membrane contact site), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0098799 (outer mitochondrial membrane protein complex), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0005739 (mitochondrion), GO:0044233 (mitochondria-associated endoplasmic reticulum membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0019866 (organelle inner membrane), GO:0031968 (organelle outer membrane), GO:0005742 (mitochondrial outer membrane translocase complex), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane), GO:0005743 (mitochondrial inner membrane)