Protein: Cyclin-dependent kinase-like 5 (B3DI12)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Mediates phosphorylation of MECP2. May regulate ciliogenesis
Subcellular location: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus
Sequence: MKIPDIGNVMNKFEVLGIVGEGAYGVVLKCRHKETKELVAIKKFKDSEENEEVKETTLRELKMLRTLKQDNIVELKEAFRRRGKLYLVFEYVEKNMLELLEELPNGALPDKVRSYIFQLIKAIHWCHKNEIVHRDIKPENLLISANDILKLCDFGFARNLSEGSDANYTEYVATRWYRSPELLLGAPYGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPPEQMKLFYSNPRFAGLRFPSVSHPQTLDRRYLGIINGLMLDLMKNLLCLNPTERFLTEQCLNHPVFQGLRGPEQPAVPSPTPPRSSKRKPYHGDNTIPSRSHGSKSSSHRRANSKDCSSLPRHEDLHRSTDSFLNGTNMPTSSTLSPTLHPKSYQAQTLSRSASSNKDLANNNLPHLLSPKDAKGKTEFDFNLGPKVGVASVGMDTSTGKYLKSSKQGRHSSFLEGKTSTLQSGDKHSRHNYMESSHGSMPSTSSSKSSSSFLSLSKSHGALNDAKSVSNLAETRLHLDDPMAGSGSGSRYFPSSCLDLNAAPGSPRGERHAGTERQGHSPSGRGSNRLEGGTLDSRRSSGRKKTPDEPKPTDTLDPSRAAGGHAHNLPSPHESYPYGLGYTSPFSSQQRPHRHSMYVRRERHRPHGQENNLVVGQGVPTRASSLQLLSPQLQHRTLPRHNTSSSREELTPELSRNDQSPKEKPHSRPLIKDSTRDNTATFHTQRPKNEAGMYHDAHMEDGTSSKENRTIYSDSMPRRVGSFYRVPSPRPDNTFLETTGQSRVQAVAAENPTMTNHSKRQTNFDPWNNSEAMVMNPPEVPKQKEKQGFFRAIKKKKKKSQPVPSETQQDQLVLQRPVKSSSHHSSRHRNRDRERERDMERDRERERDRNRDRDRERDRDNTWPPEKQPEVQPQNQPLKSLRKLLHLSSPATSNQPPPPDRSAELRFQPLPNPPSKANLNEVRGHPAGSVTPNTKSRKPHNYPLPGQIESSWHVSALNRAEGAPYPDQLANKGGQNGIGFTRAARTRMPNLNDLKETAL
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [131-143]
- IPR050108: Cyclin-dependent kinase (family) [10-297]
- IPR017441: Protein kinase, ATP binding site (binding_site) [19-43]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [8-301]
- IPR000719: Protein kinase domain (domain) [13-297]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0097472 (cyclin-dependent protein kinase activity), GO:0016301 (kinase activity), GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0031344 (regulation of cell projection organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)