Protein: Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) (P18902)
Organism: Bos taurus (Bovine)
Function: Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Subcellular location: Secreted {ECO:0000269|PubMed:12787682, ECO:0000269|PubMed:2209607, ECO:0000269|PubMed:8496140}.
Sequence: ERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETFAVQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL
InterPro domains: - IPR012674: Calycin (homologous_superfamily) [1-183]
- IPR002449: Retinol binding protein/Purpurin (family) [1-183]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [21-154]
- IPR022272: Lipocalin family conserved site (conserved_site) [14-27]
- IPR022271: Lipocalin, ApoD type (family) [4-182]
Interaction partners: - Transthyretin
- Receptor for retinol uptake STRA6
- Retinol-binding protein 1
- Vitamin D-binding protein
- Albumin
- Haptoglobin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043178 (alcohol binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0005501 (retinoid binding), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:0019840 (isoprenoid binding), GO:0031406 (carboxylic acid binding), GO:0019841 (retinol binding), GO:0033293 (monocarboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0016049 (cell growth), GO:0042221 (response to chemical), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0051707 (response to other organism), GO:0009991 (response to extracellular stimulus), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048588 (developmental cell growth), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0007584 (response to nutrient), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0016043 (cellular component organization), GO:0009994 (oocyte differentiation), GO:0009615 (response to virus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0007292 (female gamete generation), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:0043933 (protein-containing complex organization), GO:0043627 (response to estrogen), GO:0033273 (response to vitamin), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0033189 (response to vitamin A), GO:0051258 (protein polymerization), GO:0030041 (actin filament polymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)