Protein: Mitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1) (A0A0B4LFV0)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDIATLPLNNDTKDPLGAECSCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRKAMNGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [23-284]
- IPR001180: Citron homology (CNH) domain (domain) [846-1181]
- IPR050629: STE20/SPS1-related Proline-Alanine-rich Kinase (family) [11-1141]
- IPR021160: Mitogen-activated protein (MAP) kinase kinase kinase kinase (family) [10-1205]
- IPR017441: Protein kinase, ATP binding site (binding_site) [32-55]
- IPR000719: Protein kinase domain (domain) [26-283]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007610 (behavior), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0040009 (regulation of growth rate), GO:0009967 (positive regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0055088 (lipid homeostasis), GO:0012501 (programmed cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:1901700 (response to oxygen-containing compound), GO:0030534 (adult behavior), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0006793 (phosphorus metabolic process), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0010647 (positive regulation of cell communication), GO:0016043 (cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:1901185 (negative regulation of ERBB signaling pathway), GO:0032535 (regulation of cellular component size), GO:0097305 (response to alcohol), GO:0010256 (endomembrane system organization), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0000165 (MAPK cascade), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0006796 (phosphate-containing compound metabolic process), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0055090 (acylglycerol homeostasis), GO:0006915 (apoptotic process), GO:1901184 (regulation of ERBB signaling pathway), GO:0048149 (behavioral response to ethanol), GO:1902533 (positive regulation of intracellular signal transduction), GO:0006996 (organelle organization), GO:1902531 (regulation of intracellular signal transduction), GO:0042058 (regulation of epidermal growth factor receptor signaling pathway), GO:0043408 (regulation of MAPK cascade), GO:0032006 (regulation of TOR signaling), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0045471 (response to ethanol), GO:0051403 (stress-activated MAPK cascade), GO:0006468 (protein phosphorylation), GO:0008361 (regulation of cell size), GO:0016310 (phosphorylation), GO:0007030 (Golgi organization), GO:0043410 (positive regulation of MAPK cascade), GO:0035332 (positive regulation of hippo signaling), GO:0070328 (triglyceride homeostasis), GO:0032008 (positive regulation of TOR signaling), GO:0035330 (regulation of hippo signaling), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway), GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade), GO:0007254 (JNK cascade), GO:0046328 (regulation of JNK cascade), GO:0045793 (positive regulation of cell size), GO:1903432 (regulation of TORC1 signaling), GO:1904263 (positive regulation of TORC1 signaling), GO:0032874 (positive regulation of stress-activated MAPK cascade), GO:0046330 (positive regulation of JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)