Protein: T-complex protein 1 subunit delta (TCP-1-delta) (A45) (CCT-delta) (P80315)
Organism: Mus musculus (Mouse)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:23807208}. Melanosome {ECO:0000250|UniProtKB:P50991}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23807208}.
Sequence: MPENVASRSGAPTAGPGSRGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDVEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [154-419]
- IPR012717: T-complex protein 1, delta subunit (family) [24-539]
- IPR053374: TCP-1 chaperonin-containing T-complex (family) [31-538]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [220-392]
- IPR054827: Thermosome subunit alpha (family) [27-538]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [44-538]
- IPR002194: Chaperonin TCP-1, conserved site (conserved_site) [49-106]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [25-537]
- IPR017998: Chaperone tailless complex polypeptide 1 (TCP-1) (family) [29-536]
Interaction partners: - T-complex protein 1 subunit alpha
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit beta
- T-complex protein 1 subunit gamma
- T-complex protein 1 subunit theta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit zeta-2
- Chaperonin containing TCP1 subunit 8-like 1
- Cell division cycle protein 20 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0051234 (establishment of localization), GO:0008037 (cell recognition), GO:0019953 (sexual reproduction), GO:0009566 (fertilization), GO:0035036 (sperm-egg recognition), GO:0009988 (cell-cell recognition), GO:0007339 (binding of sperm to zona pellucida), GO:0007338 (single fertilization), GO:0006810 (transport), GO:1901998 (toxin transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0140535 (intracellular protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0043209 (myelin sheath), GO:0044297 (cell body), GO:0005832 (chaperonin-containing T-complex), GO:0101031 (chaperone complex)