Protein: Platelet glycoprotein IX (GP-IX) (GPIX) (Glycoprotein 9) (CD antigen CD42a) (P14770)
Organism: Homo sapiens (Human)
Function: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [17-138]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [19-55]
- IPR052313: Platelet Glycoprotein Ib-IX-V Complex (family) [4-173]
- IPR001611: Leucine-rich repeat (repeat) [54-85]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [85-136]
Interaction partners: - Platelet glycoprotein Ib beta chain
- Platelet glycoprotein V
- Platelet glycoprotein Ib alpha chain
- von Willebrand factor
- Integrin alpha-IIb
- Tyrosine-protein kinase Lyn
- GTP-binding protein 1
- Integrin beta-3
- Platelet glycoprotein VI
- Platelet glycoprotein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0055085 (transmembrane transport), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0050817 (coagulation), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0050878 (regulation of body fluid levels), GO:0007596 (blood coagulation), GO:0009611 (response to wounding), GO:0051282 (regulation of sequestering of calcium ion), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0034220 (monoatomic ion transmembrane transport), GO:0050865 (regulation of cell activation), GO:0098655 (monoatomic cation transmembrane transport), GO:0042060 (wound healing), GO:0098662 (inorganic cation transmembrane transport), GO:0010543 (regulation of platelet activation), GO:0051209 (release of sequestered calcium ion into cytosol), GO:0072378 (blood coagulation, fibrin clot formation), GO:0071702 (organic substance transport), GO:0007599 (hemostasis), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0070588 (calcium ion transmembrane transport), GO:0008016 (regulation of heart contraction), GO:0006812 (monoatomic cation transport), GO:0006816 (calcium ion transport), GO:0008016 (regulation of heart contraction), GO:0030001 (metal ion transport), GO:0097553 (calcium ion transmembrane import into cytosol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)