Protein: Phosphomannomutase 1 (PMM 1) (EC 5.4.2.8) (PMMH-22) (Q92871)
Organism: Homo sapiens (Human)
Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O35621}.
Sequence: MAVTAQAARRKERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIAEQLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLRLPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDQDSFDTIHFFGNETSPGGNDFEIFADPRTVGHSVVSPQDTVQRCREIFFPETAHEA
InterPro domains: - IPR006379: HAD-superfamily hydrolase, subfamily IIB (family) [16-235]
- IPR005002: Phosphomannomutase (family) [9-255]
- IPR036412: HAD-like superfamily (homologous_superfamily) [15-254]
- IPR023214: HAD superfamily (homologous_superfamily) [15-252]
- IPR043169: Phosphomannomutase, cap domain (homologous_superfamily) [95-196]
Interaction partners: - Mannose-6-phosphate isomerase
- Mannose-1-phosphate guanylyltransferase regulatory subunit alpha
- Phosphomannomutase 2
- Hexokinase-2
- Hexokinase-1
- Hexokinase HKDC1
- Hexokinase-3
- Mannose-1-phosphate guanylyltransferase catalytic subunit beta
- Glucose-6-phosphate isomerase
- Thymidine kinase, cytosolic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0005515 (protein binding), GO:0016866 (intramolecular transferase activity), GO:0016868 (intramolecular transferase activity, phosphotransferases)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043412 (macromolecule modification), GO:0009100 (glycoprotein metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0009225 (nucleotide-sugar metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019673 (GDP-mannose metabolic process), GO:0009101 (glycoprotein biosynthetic process), GO:0009226 (nucleotide-sugar biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)