Protein: Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) (Alpha-galactosidase B) (P17050)
Organism: Homo sapiens (Human)
Function: Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
Subcellular location: Lysosome {ECO:0000269|PubMed:9741689}.
Sequence: MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCISEQLFMEMADRMAQDGWRDMGYTYLNIDDCWIGGRDASGRLMPDPKRFPHGIPFLADYVHSLGLKLGIYADMGNFTCMGYPGTTLDKVVQDAQTFAEWKVDMLKLDGCFSTPEERAQGYPKMAAALNATGRPIAFSCSWPAYEGGLPPRVNYSLLADICNLWRNYDDIQDSWWSVLSILNWFVEHQDILQPVAGPGHWNDPDMLLIGNFGLSLEQSRAQMALWTVLAAPLLMSTDLRTISAQNMDILQNPLMIKINQDPLGIQGRRIHKEKSLIEVYMRPLSNKASALVFFSCRTDMPYRYHSSLGQLNFTGSVIYEAQDVYSGDIISGLRDETNFTVIINPSGVVMWYLYPIKNLEMSQQ
InterPro domains: - IPR035373: Alpha galactosidase A, C-terminal domain (domain) [311-394]
- IPR000111: Glycoside hydrolase family 27/36, conserved site (conserved_site) [71-86]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [18-309]
- IPR002241: Glycoside hydrolase, family 27 (family) [14-401]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [18-307]
- IPR013780: Glycosyl hydrolase, all-beta (homologous_superfamily) [314-411]
Interaction partners: - Beta-hexosaminidase subunit alpha
- Beta-hexosaminidase subunit beta
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
- Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
- Beta-1,3-galactosyltransferase 5
- Lysosomal alpha-mannosidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0042803 (protein homodimerization activity), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015925 (galactosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0044248 (cellular catabolic process), GO:0044255 (cellular lipid metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009311 (oligosaccharide metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0006643 (membrane lipid metabolic process), GO:1903509 (liposaccharide metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0006665 (sphingolipid metabolic process), GO:0030149 (sphingolipid catabolic process), GO:0006664 (glycolipid metabolic process), GO:0019377 (glycolipid catabolic process), GO:0006687 (glycosphingolipid metabolic process), GO:0046466 (membrane lipid catabolic process), GO:0046479 (glycosphingolipid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0043202 (lysosomal lumen), GO:0005766 (primary lysosome)