Protein: Cyclin-dependent kinase 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Protein kinase 5) (PfPK5) (cdc2-related kinase 2) (P61075)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Serine/threonine-protein kinase. Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P04551}.
Sequence: MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKENN
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1-286]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [121-133]
- IPR050108: Cyclin-dependent kinase (family) [2-286]
- IPR017441: Protein kinase, ATP binding site (binding_site) [10-32]
- IPR000719: Protein kinase domain (domain) [4-284]
Interaction partners: - Oocyst capsule protein
- Cell division cycle protein 20 homolog, putative
- Cyclin-dependent kinases regulatory subunit
- ATPase AAA-type core domain-containing protein
- Cyclin 1
- Cyclin-dependent kinase 2 homolog
- Origin recognition complex subunit 2
- Origin recognition complex subunit 1
- Kinesin-5
- Cyclin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0050794 (regulation of cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0022402 (cell cycle process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051726 (regulation of cell cycle), GO:0044770 (cell cycle phase transition), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1903047 (mitotic cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0044772 (mitotic cell cycle phase transition), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0044843 (cell cycle G1/S phase transition), GO:0006468 (protein phosphorylation), GO:0000082 (G1/S transition of mitotic cell cycle), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030496 (midbody), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)