Protein: Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor) (KGF) (P36363)
Organism: Mus musculus (Mouse)
Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity).
Subcellular location: Secreted.
Sequence: MRKWILTRILPTLLYRSCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGIPVKGKKTKKEQKTAHFLPMAIT
InterPro domains: - IPR008996: Cytokine IL1/FGF (homologous_superfamily) [57-193]
- IPR002209: Fibroblast growth factor family (family) [38-192]
Interaction partners: - Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Pro-epidermal growth factor
- Klotho
- Fibroblast growth factor receptor 3
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Fibroblast growth factor-binding protein 1
- Vascular endothelial growth factor receptor 2
- Decorin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0042056 (chemoattractant activity), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0002376 (immune system process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007163 (establishment or maintenance of cell polarity), GO:0042303 (molting cycle), GO:0051240 (positive regulation of multicellular organismal process), GO:0022402 (cell cycle process), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0035265 (organ growth), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0022404 (molting cycle process), GO:0098727 (maintenance of cell number), GO:0007017 (microtubule-based process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009605 (response to external stimulus), GO:0048589 (developmental growth), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0008283 (cell population proliferation), GO:0042330 (taxis), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0008219 (cell death), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048771 (tissue remodeling), GO:0007049 (cell cycle), GO:0002520 (immune system development), GO:0031128 (developmental induction), GO:0009893 (positive regulation of metabolic process), GO:0001763 (morphogenesis of a branching structure), GO:0051094 (positive regulation of developmental process), GO:0019827 (stem cell population maintenance), GO:0048585 (negative regulation of response to stimulus), GO:0042633 (hair cycle), GO:0030010 (establishment of cell polarity), GO:0035148 (tube formation), GO:2000145 (regulation of cell motility), GO:0060560 (developmental growth involved in morphogenesis), GO:0072089 (stem cell proliferation), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0048608 (reproductive structure development), GO:0045787 (positive regulation of cell cycle), GO:0010632 (regulation of epithelial cell migration), GO:0051656 (establishment of organelle localization), GO:0060688 (regulation of morphogenesis of a branching structure), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0006935 (chemotaxis), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0048736 (appendage development), GO:0048645 (animal organ formation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0001568 (blood vessel development), GO:0008285 (negative regulation of cell population proliferation), GO:0001974 (blood vessel remodeling), GO:0009799 (specification of symmetry), GO:0051649 (establishment of localization in cell), GO:0035107 (appendage morphogenesis), GO:0000226 (microtubule cytoskeleton organization), GO:0060740 (prostate gland epithelium morphogenesis), GO:2000147 (positive regulation of cell motility), GO:0090598 (male anatomical structure morphogenesis), GO:0009891 (positive regulation of biosynthetic process), GO:0061061 (muscle structure development), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0021536 (diencephalon development), GO:0010941 (regulation of cell death), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0051653 (spindle localization), GO:0045596 (negative regulation of cell differentiation), GO:0050673 (epithelial cell proliferation), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0022405 (hair cycle process), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:0060548 (negative regulation of cell death), GO:0030154 (cell differentiation), GO:0060512 (prostate gland morphogenesis), GO:0048731 (system development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0035019 (somatic stem cell population maintenance), GO:0035295 (tube development), GO:0051726 (regulation of cell cycle), GO:0009887 (animal organ morphogenesis), GO:0035112 (genitalia morphogenesis), GO:0030900 (forebrain development), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0001942 (hair follicle development), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0007548 (sex differentiation), GO:0048839 (inner ear development), GO:0008284 (positive regulation of cell population proliferation), GO:0016477 (cell migration), GO:0110110 (positive regulation of animal organ morphogenesis), GO:0035239 (tube morphogenesis), GO:0046660 (female sex differentiation), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009798 (axis specification), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0050920 (regulation of chemotaxis), GO:0031069 (hair follicle morphogenesis), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0061138 (morphogenesis of a branching epithelium), GO:0038034 (signal transduction in absence of ligand), GO:0009880 (embryonic pattern specification), GO:0048144 (fibroblast proliferation), GO:0045165 (cell fate commitment), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0048534 (hematopoietic or lymphoid organ development), GO:0050921 (positive regulation of chemotaxis), GO:0000278 (mitotic cell cycle), GO:0060562 (epithelial tube morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008593 (regulation of Notch signaling pathway), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0010001 (glial cell differentiation), GO:0051294 (establishment of spindle orientation), GO:0035272 (exocrine system development), GO:0050678 (regulation of epithelial cell proliferation), GO:0060993 (kidney morphogenesis), GO:0010468 (regulation of gene expression), GO:1901099 (negative regulation of signal transduction in absence of ligand), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0030540 (female genitalia development), GO:0045747 (positive regulation of Notch signaling pathway), GO:0021983 (pituitary gland development), GO:0071599 (otic vesicle development), GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand), GO:0042472 (inner ear morphogenesis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007423 (sensory organ development), GO:0048806 (genitalia development), GO:0071774 (response to fibroblast growth factor), GO:0060479 (lung cell differentiation), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:0030111 (regulation of Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)