Protein: Testin-2 (CMB-23) [Cleaved into: Testin-1 (CMB-22)] (P15242)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Secreted.
Sequence: MIAVLFLAILCLEVDSTAPTPDPSLDVEWNEWRTKHGKTYNMNEERLKRAVWEKNFKMIELHNWEYLEGRHDFTMAMNAFGDLTNIEFVKMMTGFQRQKIKKTHIFQDHQFLYVPKRVDWRQLGYVTPVKNQGHCASSWAFSATGSLEGQMFRKTERLIPLSEQNLLDCMGSNVTHGCSGGFMQYAFQYVKDNGGLATEESYPYRGQGRECRYHAENSAANVRDFVQIPGSEEALMKAVAKVGPISVAVDASHGSFQFYGSGIYYEPQCKRVHLNHAVLVVGYGFEGEESDGNSFWLVKNSWGEEWGMKGYMKLAKDWSNHCGIATYSTYPIV
InterPro domains: - IPR013128: Peptidase C1A (family) [27-326]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [295-314]
- IPR039417: Papain-like cysteine endopeptidase (domain) [115-331]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [114-332]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [22-332]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [274-284]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [29-88]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0033218 (amide binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0042277 (peptide binding), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0048771 (tissue remodeling), GO:0051716 (cellular response to stimulus), GO:0001503 (ossification), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0042594 (response to starvation), GO:1901698 (response to nitrogen compound), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0019538 (protein metabolic process), GO:0046849 (bone remodeling), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0031668 (cellular response to extracellular stimulus), GO:0001894 (tissue homeostasis), GO:0071496 (cellular response to external stimulus), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0060249 (anatomical structure homeostasis), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0030097 (hemopoiesis), GO:0071559 (response to transforming growth factor beta), GO:0097305 (response to alcohol), GO:0034097 (response to cytokine), GO:0010243 (response to organonitrogen compound), GO:0002521 (leukocyte differentiation), GO:0006508 (proteolysis), GO:0009267 (cellular response to starvation), GO:0071310 (cellular response to organic substance), GO:0031667 (response to nutrient levels), GO:0045453 (bone resorption), GO:0014070 (response to organic cyclic compound), GO:0031669 (cellular response to nutrient levels), GO:0071363 (cellular response to growth factor stimulus), GO:0120127 (response to zinc ion starvation), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0045471 (response to ethanol), GO:1903131 (mononuclear cell differentiation), GO:0034612 (response to tumor necrosis factor), GO:0032868 (response to insulin), GO:0034224 (cellular response to zinc ion starvation), GO:0071345 (cellular response to cytokine stimulus), GO:0071356 (cellular response to tumor necrosis factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0009986 (cell surface)