Protein: RNA-binding protein 15 (F1RCY7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus membrane; Peripheral membrane protein. Nucleus speckle. Nucleus, nucleoplasm
Sequence: MKGKERSPVKKRSRALDDIRDRGGSHPTSKKMGVISNSGGGSNNGNSSSKSDGGSARRGLLGDKRDGREFDGHVSSRTGNNHGYTSPVASSSGKNHASSLSLEAARTNSRGEARAPLPTNESEYKTLKISELGSQLSDEEIEDGLFHEFKKFGDVSVKISRVNDERIAFVNFRRPDDARAAKHARGRLVLYDRPLKIEAVYLNRRRSRSPVKEDHFSVVAGHRHLHTQRPLSPTGLGYRDYRLQQLALGRLPPPPPPPLPRELEREREFAFYEARARPAYIAERAAPFREEDFISPEDDQRANRTLFLGNLDITVTENDLRRAFERFGTITEVDIKRPTRGQSSTYGFLKFENLDMAHRAKISMSGKVVGRNPIKIGYGKATPTTRLWVGGLGPWVPLTALAREFDRFGTIRTIDYRKGDTWAYIQYESLDAAQAACTHMRGFPLGGPDRRLRVDFADTEHRYQQQFLQPLPLQHYEIMAESFVHRATPEAIRVRERTPPPLHFRERELYAGAEWPAPTIRERVRTPAFEPLEHLERERRREAWSLERELPGREAARKRRLMEDGRHLECSPDSSSEWAARRRRPPSLEGSPGGSSRDGRFSDSERPARADRVSPARESRSSLDRVPGEKRIKSNSNLSESSIGASPAERKRKAGDSAKGASKRDRSESSSKSNQASKQDAGGKLSMAWNGMLLLKNSNFPASMHLLEGDLSVATSLLIDGSTGGKVSQLRITQRLRLDQPKIDEVSRRIKVAGPGGYAVLLAVPGSSEETSSSDPAASTQRPLRNLVSYLKQKQAAGVISLPVGGSRDKDNTGVLHAFPPCDFSQQFLDSSAKALAKTEEDFLVMIVVRGAS
InterPro domains: - IPR012921: Spen paralogue and orthologue SPOC, C-terminal (domain) [684-850]
- IPR016194: SPOC-like, C-terminal domain superfamily (homologous_superfamily) [678-851]
- IPR034470: RBM15, RNA recognition motif 1 (domain) [124-201]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [118-458]
- IPR010912: Spen paralogue/orthologue C-terminal, metazoa (domain) [678-852]
- IPR034473: RBM15, RNA recognition motif 3 (domain) [386-458]
- IPR000504: RNA recognition motif domain (domain) [125-459]
- IPR034472: RBM15, RNA recognition motif 2 (domain) [297-383]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [126-457]
Interaction partners: - Pre-mRNA-splicing regulator WTAP
- Zinc finger CCCH domain-containing protein 13
- Protein virilizer homolog isoform X2
- N(6)-adenosine-methyltransferase non-catalytic subunit METTL14
- RNA N(6)-adenosine-methyltransferase mettl16
- RNA demethylase ALKBH5
- N(6)-adenosine-methyltransferase subunit METTL3
- E3 ubiquitin-protein ligase Hakai
- YTH domain-containing family protein
- rRNA N(6)-adenosine-methyltransferase METTL5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0001510 (RNA methylation), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0080009 (mRNA methylation), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0016556 (mRNA modification), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)