Protein: LD08669p (Slimb) (Supernumerary limbs, isoform A) (Supernumerary limbs, isoform C) (Q9VDE3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MMKMETDKIMDETNSNAQAFTTTMLYDPVRKKDSSPTYQTERELCFQYFTQWSESGQVDFVEHLLSRMCHYQHGQINAYLKPMLQRDFITLLPIKGLDHIAENILSYLDAESLKSSELVCKEWLRVISEGMLWKKLIERKVRTDSLWRGLAERRNWMQYLFKPRPGQTQRPHSFHRELFPKIMNDIDSIENNWRTGRHMLRRINCRSENSKGVYCLQYDDGKIVSGLRDNTIKIWDRTDLQCVKTLMGHTGSVLCLQYDDKVIISGSSDSTVRVWDVNTGEMVNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMTSPSEITLRRVLVGHRAAVNVVDFDEKYIVSASGDRTIKVWSTSSCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNSIRLWDIECGACLRVLEGHEELVRCIRFDTKRIVSGAYDGKIKVWDLVAALDPRAASNTLCLNTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNFTPNENKTGRTPSPALMEH
InterPro domains: - IPR019775: WD40 repeat, conserved site (conserved_site) [263-440]
- IPR001680: WD40 repeat (repeat) [199-488]
- IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [263-440]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [193-487]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [81-165]
- IPR050995: WD repeat and F-box domain-containing protein (family) [20-493]
- IPR001810: F-box domain (domain) [97-136]
- IPR021977: D domain of beta-TrCP (domain) [46-85]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [205-488]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140767 (enzyme-substrate adaptor activity), GO:1990756 (ubiquitin ligase-substrate adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:2000241 (regulation of reproductive process), GO:0007163 (establishment or maintenance of cell polarity), GO:0008283 (cell population proliferation), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0007623 (circadian rhythm), GO:0071704 (organic substance metabolic process), GO:2000242 (negative regulation of reproductive process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:1903684 (regulation of border follicle cell migration), GO:0030703 (eggshell formation), GO:0044085 (cellular component biogenesis), GO:0030010 (establishment of cell polarity), GO:0048729 (tissue morphogenesis), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:1903688 (positive regulation of border follicle cell migration), GO:0007308 (oocyte construction), GO:0032886 (regulation of microtubule-based process), GO:0044087 (regulation of cellular component biogenesis), GO:1904746 (negative regulation of apoptotic process involved in development), GO:0071695 (anatomical structure maturation), GO:0007626 (locomotory behavior), GO:0051726 (regulation of cell cycle), GO:0000902 (cell morphogenesis), GO:0010632 (regulation of epithelial cell migration), GO:1904748 (regulation of apoptotic process involved in development), GO:0048469 (cell maturation), GO:0032878 (regulation of establishment or maintenance of cell polarity), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0009994 (oocyte differentiation), GO:0051128 (regulation of cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0010564 (regulation of cell cycle process), GO:0007276 (gamete generation), GO:0030707 (follicle cell of egg chamber development), GO:0007281 (germ cell development), GO:0007309 (oocyte axis specification), GO:0009798 (axis specification), GO:1901564 (organonitrogen compound metabolic process), GO:0007293 (germarium-derived egg chamber formation), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0048138 (germ-line cyst encapsulation), GO:0048512 (circadian behavior), GO:0043170 (macromolecule metabolic process), GO:2000147 (positive regulation of cell motility), GO:2000026 (regulation of multicellular organismal development), GO:0048134 (germ-line cyst formation), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0046843 (dorsal appendage formation), GO:0045596 (negative regulation of cell differentiation), GO:0007306 (egg chorion assembly), GO:0007622 (rhythmic behavior), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0045475 (locomotor rhythm), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0060251 (regulation of glial cell proliferation), GO:0048139 (female germ-line cyst encapsulation), GO:0002009 (morphogenesis of an epithelium), GO:0030334 (regulation of cell migration), GO:0090162 (establishment of epithelial cell polarity), GO:0030708 (germarium-derived female germ-line cyst encapsulation), GO:0022607 (cellular component assembly), GO:0046599 (regulation of centriole replication), GO:0050768 (negative regulation of neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0048135 (female germ-line cyst formation), GO:0048599 (oocyte development), GO:0030335 (positive regulation of cell migration), GO:0060253 (negative regulation of glial cell proliferation), GO:0046605 (regulation of centrosome cycle), GO:0010824 (regulation of centrosome duplication), GO:0006508 (proteolysis), GO:0060284 (regulation of cell development), GO:0007304 (chorion-containing eggshell formation), GO:0048477 (oogenesis), GO:0051960 (regulation of nervous system development), GO:0045229 (external encapsulating structure organization), GO:0030727 (germarium-derived female germ-line cyst formation), GO:2000114 (regulation of establishment of cell polarity), GO:1902115 (regulation of organelle assembly), GO:0030855 (epithelial cell differentiation), GO:0010634 (positive regulation of epithelial cell migration), GO:0033043 (regulation of organelle organization), GO:0060429 (epithelium development), GO:0010721 (negative regulation of cell development), GO:0042981 (regulation of apoptotic process), GO:0014014 (negative regulation of gliogenesis), GO:0050767 (regulation of neurogenesis), GO:0033044 (regulation of chromosome organization), GO:0016333 (morphogenesis of follicular epithelium), GO:0051783 (regulation of nuclear division), GO:0043066 (negative regulation of apoptotic process), GO:0014013 (regulation of gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)