Protein: Tubulin-folding cofactor D (AtTFCD) (Protein CHAMPIGNON) (Protein EMBRYO DEFECTIVE 133) (Protein TITAN 1) (Q8L5R3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Regulates microtubule function in seed development. Required for development of both embryo and endosperm tissue. Not essential for cell viability. Probably involved in the binding of beta-tubulin in the multimeric supercomplex.
Sequence: MASRAEEMSPTKIEIETAVKIEEEEDDEHDSKERVLQRYFLQEWKLVKSLLDDIVSNGRVVDPTSVHKIRSIMDKYQEQGQLVEPYLESIVSPLMFIIRSKTVDLEAKPDEILEIIKPISIIIYALVTVCGYKAVIKFFPHQVSDLELAVLLLEKCHSTNSVSALRQESTGEMEAKCVTLLWLSILVLVPFDISSVDTSIADDKTFGVDDLAPLVLKILGFCKDYLCSAGPMRRISGLLLSKLLTRPDMGKAFSSFFEWTYEVLSCKEDSVTNHFRLLGVMEALSAIFKTASRKVLLDVLPIVLNDVTVLSKSNAAAKSSLLRKYLIKLTQRIGLVCLPHRSPSWRYVAQTASLSENMSTSSSQRLAPDHTVTAILQPESLDDQEDEDMDVPEILEEIIEMLLSGLRDTDTVVRWSAAKGIGRVTSRLTSVLSDEVLSSVLELFSPGEGDGSWHGGCLALAELARRGLLLPRSFPLVVPVIVKALHYDVRRGPHSVGSHVRDAAAYVCWAFGRAYSHKDMKNVLDQLAPDLLIVGSFDREVNCRRAAAAAFQENVGRQGNYPHGIDIVSIADYFSLSSRVNSYLQVAVSIAQYEGYLYPFVDELLYNKICHWDKSLRELAAEALAPLVKYEPKHFANYVLEKLIPCTLSTDLCMRHGATLAAGEVVLALHQCGYVLSADSQKRMAGIVPSIEKARLYRGKGGEIMRLAVSRFIECISLSHVTLAERTERILLDTLTENLRHPNSQIQNAAVSAVKQLVQSYLVGNDKKSVDLILKHLKHLTDPNVAVRRGSALALGVLPYELLTAKWKDIVLKLCSACKIEVNPEDRDAEARVNAVKGLTSVCETLTQKRASDPGNDDLSLFLLIKTEVMDTLLKALDDYSVDNRGDVGSWVREAAVHGLEKCTYILCKKMETYSEGDYNDDTSSLFDSNLATRLIGGMLKQGVEKMDKLRETAAKVLQRILYHKSVSVPHVPYREKLEEILPNKANLQWAVPAFSFPRFVQLLKLRCYSKEVMSGLVISIGGLQDSLRKASLVALLEYMREGEAKDPKEQQSRESALGDDILWILQEYKKCDRVMVPCLQTIEILFSSKIFLNQESYTFSFYAGVMDSLAIELRASKDFTKLKAGLAILGYIASVSHFISTKAFSQLLSFLGHRYPMIRKAAAEQVYLALLQNGILVTEEKMEKVIEIISESCWEADMETTKTQRLELCELAGLDHEVVFKTRNRLVIKDIAGNKSAADENASYSSLVDSSGF
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [378-1082]
- IPR058033: Tubulin-folding cofactor D, ARM repeats (domain) [321-565]
- IPR011989: Armadillo-like helical (homologous_superfamily) [253-1069]
- IPR033162: Tubulin-folding cofactor D (family) [15-1220]
- IPR022577: Tubulin-folding cofactor D, C-terminal domain (domain) [934-1122]
Interaction partners: - ADP-ribosylation factor-like protein 2
- Tubulin-folding cofactor B
- Tubulin-folding cofactor E
- Prefoldin subunit 4
- Gamma-tubulin complex component
- Mitotic spindle checkpoint protein MAD2
- Gamma-tubulin complex component
- Mitotic spindle checkpoint protein MAD1
- Protein NEDD1
- Transducin family protein / WD-40 repeat family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity), GO:0015631 (tubulin binding), GO:0048487 (beta-tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1900457 (regulation of brassinosteroid mediated signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)