Protein: WASH complex subunit homolog 5 (WASH complex subunit strumpellin homolog) (Q9VUY8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail.
Subcellular location: Early endosome {ECO:0000305}.
Sequence: MSFLDDNNACGQNLLNIVSVGNSIIAEILRLKDYVPSIYRLDNKADKAKYGELILDFSYFKIAEDHERRIEQSPELTELDDEARAQLPLITRFYLAFQSIHHYASDLQQYIEELNTGYYIQQTLETVLQEEEGRQLLCESLYLFGVILLMVDFHIPGDVRERLLIAYYRYSGGDATPSGDESNIHDVCLLLRSTGYVHPSIAAKVLGLGGKQAGARAASLVVPRYPEAYFSRFRFDENFVDLVVARLRCDDIYNQLNLYPHPAHRSTALSTQAAMLYVCLYFCPQVLHSQGSQMREIVDKFFCDNWTISVYMGMTVNLVDAWLDFKAARSAIENVISPPAIKALCQQQKEQLGKITQKTQEIVREGVLNDNFVLEHANKIIHLMRQSNVLLRWFCLHTSREVFIFAHTATLTGQVQKCVLHELQFNRNTLYNLLLNCSQMELSVREFLAEIQQTKEERWTKSREEAMQRLNELSEAFAGSRPLSKIEQNPQLQQWFGEVAGRLQKLELSRPQKSGRLIIQVMQALDDVQEYHNLHSNMLVKQQLQETRDMLNQMAQLINLKEDIEIHIQMITDFSYAWHLLQFDFTPPMQEHIKRQPQAVIGIRAVFLKLASTLEVPLMRINQARSEDLVSVSNYYSTELANFLRRVLQIVPETMFSILAKIIYLLTNVIKEFPTKVEKERLKDYAQFEERAKVAQLTNSIAVFTKGILMMKTTLVGVIELDPKQLLEDGIRKELVNHLANAYNLGLIFTPEKGKTPVQLLQQKLQALAKTIEGYRRSFEYIEDYLRVQGLRILLEESQRIINYNVEKECNAFLRNKVQEFQSEHQSQIIPIPNFPPLLGDPSNNFIGRLAHEILRCTDPKQTIFLDLKSTWYEKKAPHQEVLAGSGFFEILREALAPAGMVGLERLYAHMLADELKRNLERLQRNLTSDRMWVDTLAALTRELEARDFPTPEVSKQPLKYYQAYTQRWLKVWPTLLDWVLCIGQKQLLRREIAGELSFSSKCDAKLLENTADTLNKALLLELSLSKDLCDEKGVVMLTELQETLLYTGNFEPLEQVFLITKNTHNMALFMFLFTIAHLGRMQHSTITDCLLPKSAKDNIDNVPFIVGLVTILQQFHKNVKMLYISYMSQYVVTVSEAQLLDKEILGPEVVTALHFLLAFIRIARLPLGVLEQRIPNIILSEYEYLSTLLK
InterPro domains: - IPR019393: WASH complex, subunit strumpellin (family) [1-1184]
Interaction partners: - WASH complex subunit 4
- WASH complex subunit 3
- WASH complex subunit 2
- WASH complex subunit 1
- F-actin-capping protein subunit beta
- F-actin-capping protein subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051649 (establishment of localization in cell), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:1990849 (vacuolar localization), GO:0006810 (transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis), GO:0016197 (endosomal transport), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0061024 (membrane organization), GO:0016050 (vesicle organization), GO:0007032 (endosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0031209 (SCAR complex), GO:0005737 (cytoplasm)