Protein: 60S ribosomal export protein NMD3 (Nonsense-mediated mRNA decay protein 3) (P38861)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Unlikely to play a significant role in nonsense-mediated mRNA decay (NMD).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:11086007}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11086007}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.
Sequence: MEFTPIDPHQHQNAATLLCCNCGTPIDGSTGLVMCYDCIKLTVDITQGIPREANISFCRNCERFLQPPGQWIRAELESRELLAICLRRLKGLTKVRLVDASFIWTEPHSRRIRIKLTVQGEAMTNTIIQQTFEVEYIVIAMQCPDCARSYTTNTWRATVQIRQKVPHKRTFLFLEQLILKHNAHVDTISISEAKDGLDFFYAQKNHAVKMIDFLNAVVPIKHKKSEELISQDTHTGASTYKFSYSVEIVPICKDDLVVLPKKLAKSMGNISQFVLCSKISNTVQFMDPTTLQTADLSPSVYWRAPFNALADVTQLVEFIVLDVDSTGISRGNRVLADITVARTSDLGVNDQVYYVRSHLGGICHAGDSVMGYFIANSNYNSDLFDGLNIDYVPDVVLVKKLYQRKSKKSRHWKLKRMAKEHKDIDASLDYNSRAQKQEMERAEKDYELFLQELEEDAELRQSVNLYKNREANVPPEEHEMDEDEDEDAPQINIDELLDELDEMTLEDGVENTPVESQQ
InterPro domains: - IPR048898: 60S ribosomal export protein NMD3, OB-fold domain (domain) [315-400]
- IPR048899: 60S ribosomal export protein NMD3, SH3 domain (domain) [251-299]
- IPR039768: Ribosomal export protein Nmd3 (family) [9-502]
- IPR007064: Nmd3, N-terminal (domain) [19-248]
Interaction partners: - Cytoplasmic 60S subunit biogenesis factor REI1
- Eukaryotic translation initiation factor 6
- Large ribosomal subunit protein uL16
- Probable metalloprotease ARX1
- Large subunit GTPase 1
- Nucleolar GTP-binding protein 1
- Ribosome biogenesis protein RLP24
- Exportin-1
- Bud site selection protein 20
- Ribosome assembly factor MRT4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0044877 (protein-containing complex binding), GO:0030674 (protein-macromolecule adaptor activity), GO:0043021 (ribonucleoprotein complex binding), GO:0043023 (ribosomal large subunit binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0006403 (RNA localization), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051236 (establishment of RNA localization), GO:0043170 (macromolecule metabolic process), GO:0050658 (RNA transport), GO:0071705 (nitrogen compound transport), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0010467 (gene expression), GO:0015931 (nucleobase-containing compound transport), GO:0006913 (nucleocytoplasmic transport), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0051028 (mRNA transport), GO:0006406 (mRNA export from nucleus), GO:0006405 (RNA export from nucleus), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0051168 (nuclear export), GO:0050657 (nucleic acid transport), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0030684 (preribosome), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0030686 (90S preribosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0032040 (small-subunit processome), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)