Protein: Synaptotagmin-11 (Synaptotagmin XI) (SytXI) (Q9BT88)
Organism: Homo sapiens (Human)
Function: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000305|PubMed:12925569}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q9R0N3}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Lysosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9R0N3}. Cell projection, axon {ECO:0000269|PubMed:12925569}. Cell projection, dendrite {ECO:0000269|PubMed:12925569}. Postsynaptic density {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O08835}; Single-pass membrane protein {ECO:0000250|UniProtKB:O08835}. Perikaryon {ECO:0000269|PubMed:12925569}. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (By similarity). Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients (PubMed:12925569). {ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:12925569}.
Sequence: MAEITNIRPSFDVSPVVAGLIGASVLVVCVSVTVFVWSCCHQQAEKKQKNPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPGREGGRRNLLVDAAEAGLLSRDKDPRGPSSGSCIDQLPIKMDYGEELRSPITSLTPGESKTTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTASGAEHWREVCESPRKPVAKWHSLSEY
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [142-430]
- IPR001565: Synaptotagmin (domain) [161-263]
- IPR000008: C2 domain (domain) [157-426]
Interaction partners: - E3 ubiquitin-protein ligase parkin
- Synaptotagmin-1
- Vesicle-associated membrane protein 2
- Synaptotagmin-2
- Coiled-coil domain-containing protein 62
- Clathrin coat assembly protein AP180
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0051051 (negative regulation of transport), GO:0045927 (positive regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0032879 (regulation of localization), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0030307 (positive regulation of cell growth), GO:0051128 (regulation of cellular component organization), GO:0051953 (negative regulation of amine transport), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0048638 (regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051952 (regulation of amine transport), GO:0022604 (regulation of cell morphogenesis), GO:0033604 (negative regulation of catecholamine secretion), GO:1903859 (regulation of dendrite extension), GO:1903861 (positive regulation of dendrite extension), GO:0051046 (regulation of secretion), GO:0050433 (regulation of catecholamine secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle)