Protein: G-protein coupled receptor 1 (O04714)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP(3)) as a second messenger. Promotes PI-PLC activity and IP(3) accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Probably involved in cytokinin signal transduction. Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein. Mediates seed dormancy abolition, and promotes seed germination and flowering.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15181210, ECO:0000269|Ref.7}; Multi-pass membrane protein {ECO:0000269|PubMed:15181210, ECO:0000269|Ref.7}. Note=Localized to the outer edge of the leaf epidermal cells in a punctuate pattern.
Sequence: MSAVLTAGGGLTAGDRSIITAINTGASSLSFVGSAFIVLCYCLFKELRKFSFKLVFYLALSDMLCSFFLIVGDPSKGFICYAQGYTTHFFCVASFLWTTTIAFTLHRTVVKHKTDVEDLEAMFHLYVWGTSLVVTVIRSFGNNHSHLGPWCWTQTGLKGKAVHFLTFYAPLWGAILYNGFTYFQVIRMLRNARRMAVGMSDRVDQFDNRAELKVLNRWGYYPLILIGSWAFGTINRIHDFIEPGHKIFWLSVLDVGTAALMGLFNSIAYGFNSSVRRAIHERLELFLPERLYRWLPSNFRPKNHLILHQQQQQRSEMVSLKTEDQQ
InterPro domains: - IPR022343: GCR1-cAMP receptor (family) [30-272]
- IPR017981: GPCR, family 2-like, 7TM (domain) [19-273]
- IPR022340: G protein-coupled receptor GCR1 putative (family) [19-279]
Interaction partners: - Guanine nucleotide-binding protein alpha-1 subunit
- LanC-like protein GCR2
- GPCR-type G protein 2
- GPCR-type G protein 1
- Guanine nucleotide-binding protein subunit gamma 1
- Guanine nucleotide-binding protein subunit beta
- Regulator of G-protein signaling 1
- Guanine nucleotide-binding protein subunit gamma 2
- Guanine nucleotide-binding protein subunit gamma 3
- Pirin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0036094 (small molecule binding), GO:0005515 (protein binding), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0043177 (organic acid binding), GO:1901149 (salicylic acid binding), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:1901338 (catecholamine binding), GO:0031406 (carboxylic acid binding), GO:0004930 (G protein-coupled receptor activity), GO:0033293 (monocarboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:1901419 (regulation of response to alcohol), GO:0009966 (regulation of signal transduction), GO:0006970 (response to osmotic stress), GO:1905958 (negative regulation of cellular response to alcohol), GO:1901700 (response to oxygen-containing compound), GO:1905957 (regulation of cellular response to alcohol), GO:1901420 (negative regulation of response to alcohol), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0097305 (response to alcohol), GO:0009787 (regulation of abscisic acid-activated signaling pathway), GO:0033993 (response to lipid), GO:0009788 (negative regulation of abscisic acid-activated signaling pathway), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)