Protein: Ribonucleoside-diphosphate reductase (Q5A0N3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Sequence: MYVYKRDGRKEPVRFDKITARVQRLCYGLNPNHVEPVAITQKVISGVYQGVTTIELDNLAAEIAATMTTIHPDYAVLAARIAVSNLHKQTTKQYSKVSKDLYEYINPKTGLHSPMISKETYDIIMEHEDELNSAIVYDRDFNYNYFGFKTLERSYLLRINGKVAERPQHLIMRVAVGIHGNDIPRVIETYNLMSQRFFTHGSPCLFNAGTPRPQMSSCFLLAMKDDSIEGIYDTLKSCALISKSAGGIGLHIHNIRSTGAYIAGTNGTSNGIIPMVRVFNNTARYVDQGGNKRPGAFALYLEPWHSDIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEQNGDWTLFSPNEAPGLADVYGDEFEELYTKYEKENRGRQTIKAQKLWYAILGAQTETGTPFMLYKDSCNNKSNQKNLGIIKSSNLCCEIVEYSAPDEVAVCNLASIALPSFVENDEKSTWYNFDKLHQVTKVVTRNLNRVIDRNHYPVPEAERSNMRHRPIALGVQGLADAFMELRLPFDSQEARELNIQIFETIYHAAVEASIELAKEEGAYETYPGSPASQGLLQFDLWNRKPTELWDWDTLKQDLAKHGMRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLAGEFQIVNPYLLKDLVDLGVWNDAMKSSIIANNGSIQALPNIPDEIKALYKTVWEISQKHIIDMAADRAAFIDQSQSLNIHIKDPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQFTIDQKIAETAGHTVANLDKLNIKKYVNKGRVESENTSDAPYKSPSTEPTSLESSVADLKIKDEGEKPAEDKTIEELENDIYSAKVIACAIDNPESCTMCSG
InterPro domains: - IPR039718: Ribonucleoside-diphosphate reductase large subunit (family) [1-853]
- IPR008926: Ribonucleotide reductase R1 subunit, N-terminal (homologous_superfamily) [6-214]
- IPR013346: Ribonucleotide reductase, class I, alpha subunit, C-terminal (domain) [145-745]
- IPR000788: Ribonucleotide reductase large subunit, C-terminal (domain) [216-741]
- IPR005144: ATP-cone domain (domain) [1-92]
- IPR013509: Ribonucleotide reductase large subunit, N-terminal (domain) [142-212]
Interaction partners: - Ribonucleotide-diphosphate reductase subunit
- Rnr22p
- Thymidylate kinase
- Nucleoside diphosphate kinase
- Guanylate kinase
- Uridylate kinase
- GTP:AMP phosphotransferase, mitochondrial
- Adenylate kinase
- Pyruvate kinase
- Ribonucleoside-diphosphate reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016725 (oxidoreductase activity, acting on CH or CH2 groups), GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor), GO:0061731 (ribonucleoside-diphosphate reductase activity), GO:0004748 (ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0043227 (membrane-bounded organelle), GO:0005971 (ribonucleoside-diphosphate reductase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)