Protein: Fork-head transcriptional regulator 2 (Q5A7S7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence
Subcellular location: Nucleus
Sequence: MSAQFITPKKRPHSPLDSNELLPSFEDPQDMINAVVSTLSAPEEKTNVSIAYANEKNQATEIQAYAKIAGKDWTFYVKSLAVSIGRNIELSAPSNTNITTPLIDIDLGPAKVVSRSHAAITYNLDLRCWELKVLGRNGARIDGQKVNVDSPNVNALHSGAILDIGGTQMMFILPDAPAVVAPKMLEKCLLRYKEQQQQQNKRISSGPGIGGSTSFQMFDKAHLTHSPSSISANSLQSNLDQDLSKEEAKDIKPPYSYATMITQAILSNPQGVMSLSEIYNWIADHYAYYKYSKTGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWQISESYKEEFLNKISDGTISKTRRGSSVSRQLSLHLATHNQLPESHKYTMDQQIHNGTAASIPQQQKQQQQQQKRPPQQQNSQPHLSQPHYTIPSNPMQTNSMGYIPQSNIYNMSNSDRRYTPYQQSQNPLMYQHQQQHIGQTYNQLGRPQGQLGQPMMQPQQQSYTSSNIKTEPSSPKRNPSISNNTPKMAKGTVSTESHSRSTSYTTTQLHEMSNFNSSANDSTSTAPTASTTTNGDIGLNFASPKKITALEAYTPERGSKGNPSGTNNNNNTNNTNTNTTNNNNGKNTAGGPNTNQSSPAFWNFVQFSTPNGQSPVRKSSEEVGNNSPTLNRKIKRERENDETNSPFKKKQRTEMIDS
InterPro domains: - IPR000253: Forkhead-associated (FHA) domain (domain) [81-165]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [68-176]
- IPR018122: Fork head domain conserved site1 (conserved_site) [252-265]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [238-343]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [251-340]
- IPR001766: Fork head domain (domain) [250-350]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [296-302]
Interaction partners: - Transcription factor of morphogenesis MCM1
- Cyclin-dependent kinase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0045927 (positive regulation of growth), GO:0044403 (biological process involved in symbiotic interaction), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0016049 (cell growth), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009266 (response to temperature stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0080134 (regulation of response to stress), GO:0010570 (regulation of filamentous growth), GO:0075136 (response to host), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0031324 (negative regulation of cellular metabolic process), GO:0060258 (negative regulation of filamentous growth), GO:0009891 (positive regulation of biosynthetic process), GO:0009408 (response to heat), GO:0051701 (biological process involved in interaction with host), GO:0009991 (response to extracellular stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0002833 (positive regulation of response to biotic stimulus), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0031668 (cellular response to extracellular stimulus), GO:0090033 (positive regulation of filamentous growth), GO:0080090 (regulation of primary metabolic process), GO:0036171 (filamentous growth of a population of unicellular organisms in response to chemical stimulus), GO:0071496 (cellular response to external stimulus), GO:0031347 (regulation of defense response), GO:0052200 (response to host defenses), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0009267 (cellular response to starvation), GO:0036176 (response to neutral pH), GO:1900429 (negative regulation of filamentous growth of a population of unicellular organisms), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0032104 (regulation of response to extracellular stimulus), GO:0010468 (regulation of gene expression), GO:0071467 (cellular response to pH), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0032106 (positive regulation of response to extracellular stimulus), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0031669 (cellular response to nutrient levels), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0032109 (positive regulation of response to nutrient levels), GO:0032107 (regulation of response to nutrient levels), GO:1900436 (positive regulation of filamentous growth of a population of unicellular organisms in response to starvation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0052572 (response to host immune response), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)