wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cadherin domain-containing protein (Q8CAC6)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MDLLSGTYIFAVLLACVVFQSGAQEKNYTVREEMPENVLIGDLLKDLNLSLIPDKSLTTPMQFKLVYKTGDVPLIRIEEGTGEIFTTGARIDREKLCAGIVLDARCFYEVEVAVLPDEIFRLVKIRFLIEDINDNAPLFPTTVINISIPENSAINSRYSLPAAIDPDIGINGVQNYQLIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVADTNDNHPIFIEKEIEVSIPENAPIGSSVTQLHATDADIGENARIHFYFSNLVSNIAKRLFHLNTTTGLITVKEPLDREESPSHKLLVLATDGGSTPARATVLVNVTDINDNIPSIDIRYIVNPTNGTVLLSENAPLNTKIALITVMDKDSEHNGRVTCFTDHEVPFRLRPVFSNQFLLETAAFLDFESTREYAIKLLAADAGKPPLNQSSMLLIKV
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [15-456]
- IPR002126: Cadherin-like (domain) [52-456]
- IPR013164: Cadherin, N-terminal (domain) [27-111]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [133-456]
- IPR020894: Cadherin conserved site (conserved_site) [237-353]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Laminin subunit alpha 3 (K7EIP4)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Sequence: XFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVEPCRRRKEESDKNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIKIGKLQKRMWINVDVQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGGPIFKSPQTYMDGLLHYVSVISDNSGLRQEGCLRPRVRDQSWKHSETMSLRKLK
InterPro domains: - IPR050372: Neurexin-related cell adhesion and synaptic protein (family) [14-856]
- IPR001791: Laminin G domain (domain) [650-1121]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [647-1119]
- IPR009254: Laminin alpha, domain I (domain) [107-365]
- IPR010307: Laminin domain II (domain) [548-676]
- IPR002049: Laminin-type EGF domain (domain) [1-49]
- IPR000742: EGF-like domain (domain) [15-26]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005201 (extracellular matrix structural constituent), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0060429 (epithelium development), GO:0030855 (epithelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Energy-coupling factor transporter transmembrane protein EcfT (ECF transporter T component EcfT) (Q9X2I1)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (Probable). Expression of the complex plus RibU in E.coli allows riboflavin uptake; uptake does not occur in the absence of RibU or the EcfA1A2T complex.
Subcellular location: Cell inner membrane {ECO:0000305|PubMed:23359690}; Multi-pass membrane protein {ECO:0000305|PubMed:23359690}.
Sequence: MRLPTVLIGRYIPVDSIVHRLDPRAKLLGMIFLISAVLIVPNLLFYLVPGLAIFLLMFLSRTGFKIYLAGLRSLWFFLVFAVLVQFFSSSEGEKIFWMITDRAIWSAVYIMLRLVLIILLAENFSATTPPLLSARAIESIFSTFGARKIGHEIGMVMTIAMRFVPVLALEADRILKAQIARGANFERGKFFDRIRALVVIIVPLLISALRKAEELAVAMEARLYTGEPPKTRFKDIKWKPMDTLYVLLTAGVLVLVLFGRYFVDGVFQYGS
InterPro domains: - IPR003339: ABC/ECF transporter, transmembrane component (family) [16-257]
Interaction partners: - Energy-coupling factor transporter ATP-binding protein EcfA2
- Energy-coupling factor transporter ATP-binding protein EcfA1
- Biotin transporter BioY
- Oligopeptide ABC transporter, ATP-binding protein
- tRNA pseudouridine synthase A
- ATP-dependent protease LA, putative
- Riboflavin transporter RibU
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051180 (vitamin transport), GO:0071705 (nitrogen compound transport), GO:0015711 (organic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: HEAT repeat-containing protein 1 (Q96ES5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|RuleBase:RU367065}.
Sequence: MGSASQANIRLTSLKKTLATTLAPRVLLPAIKKTYKQIEKNWKNHMGPFMSILQEHIGAMKKEELTSHQSQLTAFFLEALDFRAQHSENDLEEVGKTENCIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLDQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFISKERAGALMMPLVDQLENRLGGEEKFQERVTKHLIPCIAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLKENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETVLGEPLQSYF
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [26-347]
- IPR012954: BP28, C-terminal domain (domain) [62-216]
- IPR011989: Armadillo-like helical (homologous_superfamily) [99-349]
- IPR040191: U3 small nucleolar RNA-associated protein 10 (family) [8-349]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0035556 (intracellular signal transduction), GO:0043933 (protein-containing complex organization), GO:0007264 (small GTPase mediated signal transduction), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0007265 (Ras protein signal transduction), GO:0016601 (Rac protein signal transduction), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Protein Syd (P0A8U0)
Organism: Escherichia coli (strain K12)
Function: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.
Subcellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. Note=Loosely associated with the cytoplasmic side of the inner membrane, probably via SecY.
Sequence: MDDLTAQALKDFTARYCDAWHEEHKSWPLSEELYGVPSPCIISTTEDAVYWQPQPFTGEQNVNAVERAFDIVIQPTIHTFYTTQFAGDMHAQFGDIKLTLLQTWSEDDFRRVQENLIGHLVTQKRLKLPPTLFIATLEEELEVISVCNLSGEVCKETLGTRKRTHLASNLAEFLNQLKPLL
InterPro domains: - IPR009948: Syd (family) [3-181]
- IPR038228: Syd superfamily (homologous_superfamily) [1-181]
Interaction partners: - Der GTPase-activating protein YihI
- UPF0208 membrane protein YfbV
- Phosphohistidine phosphatase SixA
- RNA chaperone ProQ
- Regulator of ribonuclease activity B
- Negative modulator of initiation of replication
- Uncharacterized protein YjaG
- Cell division protein ZapC
- Uncharacterized protein YheV
- Uncharacterized protein YigA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1990391 (DNA repair complex)
Protein: Anon1A3 (Q9TVG2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: GVENLPSVAEAKQNHVDEVKPISEEPGNSSEEVPKAEEPLKSSGETSENGAATETAAAPKEPASVMDVDEDETLVENTPSANKEKALDDEKEPEQKSEEHAAAVLESKEQNEPAKEPTPEPMEVDGSSKGSSDTAQVDTPAIENISAAPETEAAAKTTESSNDVVEVATEGKETVLEVPAAEPKEAESTVESAEELTETSTVVVTEPKEAASSEEEPSKVVDSAEPKEAESNTDESATPVPIDVSTAPASNDVSKPLEIDTTLVKTADSPAKEPQEICEVKKAEINVNGEPKIVNSSAEVGENAAPKVCN
InterPro domains: - IPR031945: Protein of unknown function DUF4775 (family) [1-310]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019900 (kinase binding), GO:0003779 (actin binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0007610 (behavior), GO:0007611 (learning or memory), GO:0050877 (nervous system process), GO:0007613 (memory), GO:0050890 (cognition), GO:0007616 (long-term memory)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Flavin-containing monooxygenase FMO GS-OX-like 2 (EC 1.8.-.-) (Flavin-monooxygenase glucosinolate S-oxygenase-like 2) (Q9FWW9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the conversion of methylthioalkyl glucosinolates of any chain length into methylsulfinylalkyl glucosinolates.
Sequence: MATSHPDPTTSRHVAVIGAGAAGLVAARELRREGHSVVVLERGSQIGGVWAYTSQVEPDPLSLDPTRPVVHSSLYRSLRTNIPRECMGFTDFPFATRPHDGSRDPRRHPAHTEVLAYLRDFAKEFDIEEMVRFETEVVKAEQVAAEGEERGKWRVESRSSDGVVDEIYDAVVVCNGHYTEPRHALITGIDSWPGKQIHSHNYRVPDQFKDQVVIVIGSSASGVDICRDIAQVAKEVHVSSRSTSPDTYEKLTGYENLWLHSTIQIAREDGSVVFENGKTIYADTIMHCTGYKYYFPFLDTKGEVTVDDNRVGPLYKHVFPPALAPSLSFIGLPWQITPFPMFELQSKWVAAVLSGRVSLPSQDEMMEDTKAFYDKLEASGIPKRYTHLMPDDSQFEYDNWLADQCEYPRIEKWREQMFYIGFKRIYAQSSTYRDNWDDDHLIVEAYDDFVKFMSSYQELLPMLKT
InterPro domains: - IPR050346: Flavin-containing monooxygenases-like (family) [12-439]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [8-441]
- IPR020946: Flavin monooxygenase-like (family) [12-377]
- IPR000960: Flavin monooxygenase FMO (family) [12-353]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0019825 (oxygen binding), GO:0004383 (guanylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006082 (organic acid metabolic process), GO:0019757 (glycosinolate metabolic process), GO:0019760 (glucosinolate metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0016143 (S-glycoside metabolic process), GO:1901657 (glycosyl compound metabolic process), GO:0019758 (glycosinolate biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0044272 (sulfur compound biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016144 (S-glycoside biosynthetic process), GO:1901659 (glycosyl compound biosynthetic process), GO:0019761 (glucosinolate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)
Protein: BZIP domain-containing protein (A7RFN4)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: AYGRDKDQKYIEKRMKNNLAAKRSREAKRQREIEAMQKTLTLEKENSDLNKEVNKLKKMIARLENKLR
InterPro domains: - IPR040223: PAR basic leucine zipper protein (family) [6-67]
- IPR004827: Basic-leucine zipper domain (domain) [5-68]
- IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [5-65]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0045834 (positive regulation of lipid metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0045184 (establishment of protein localization), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0042304 (regulation of fatty acid biosynthetic process), GO:0019217 (regulation of fatty acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: (R)-2-hydroxyisocaproyl-CoA dehydratase alpha subunit (EC 4.2.1.157) (Q5U924)
Organism: Clostridioides difficile (Peptoclostridium difficile)
Function: Involved in the reductive branch of L-leucine fermentation. Catalyzes the irreversible beta/alpha-elimination of water from (R)-2-hydroxyisocaproyl-CoA to yield isocaprenoyl-CoA. This beta/alpha-dehydration depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI. The enzyme is specific for the R-isomer.
Sequence: MSEKKEARVVINDLLAEQYANAFKAKEEGRPVGWSTSVFPQELAEVFDLNVLYPENQAAGVAAKKGSLELCEIAESKGYSIDLCAYARTNFGLLENGGCEALDMPAPDFLLCCNNICNQVIKWYENISRELDIPLIMIDTTFNNEDEVTQSRIDYIKAQFEEAIKQLEIISGKKFDPKKFEEVMKISAENGRLWKYSMSLPADSSPSPMNGFDLFTYMAVIVCARGKKETTEAFKLLIEELEDNMKTGKSSFRGEEKYRIMMEGIPCWPYIGYKMKTLAKFGVNMTGSVYPHAWALQYEVNDLDGMAVAYSTMFNNVNLDRMTKYRVDSLVEGKCDGAFYHMNRSCKLMSLIQYEMQRRAAEETGLPYAGFDGDQADPRAFTNAQFETRIQGLVEVMEERKKLNRGEI
InterPro domains: - IPR010327: FldB/FldC dehydratase alpha/beta subunit (family) [37-397]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016836 (hydro-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006558 (L-phenylalanine metabolic process), GO:1902221 (erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)