Protein: Phosphoinositide phosphatase SAC8 (AtSAC8) (EC 3.1.3.-) (Protein SUPPRESSOR OF ACTIN 1A) (AtSAC1a) (Protein SUPPRESSOR OF ACTIN 8) (Putative transmembrane protein G5p) (AtG5) (SAC domain protein 8) (SAC1-like protein AtSAC1a) (Q96328)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12713536}; Multi-pass membrane protein {ECO:0000269|PubMed:12713536}.
Sequence: MEIAPSTSRFKLYDQFELLEFPDKYVVKPIESPEEGFSVNRRDGNIKPLDENASSGSPTRVSTIYGVGGTIRLLAGTYLLVITSREEVGNFLGLPIFRVTAMKFLPCNEALRFATAQEKKDETYFRTLLQALETTPGLYFSYETDLTLNLQRRCKLAEGWNRKPMWKQADPRYVWNWHLLEDLIECKLDGFIIPILQGSYQVAELKLKNSPAVVSIMSRRCTRRLGTRMWRRGANLEGDAANFVESEQIVEINGFKFSLLQVRGSIPLLWEQIVDLSYKPRLKINKHEETPKVVQRHFHDLCQRYGEIMAVDLTDQHGDEGALSKAYATEMEKLPDVRYVSFDFHQVCGTTNFDNLGVLYEQIGDEFEKQGYFLVDADENILEEQKGVIRSNCIDCLDRTNVTQSFMGQKSLNLQLQRIGVCDSTECISTFEDDYTKFRTIWAEQGDEVSLQYAGTYALKGDLVRYGKQTMTGAIKDGLSAMSRYYLNNFQDGVRQDALDLISGRYTVGTHSPSQLQPIGSQPSFLPVASALLIGGVTVTSFTIHQAGRNTQQYLASALWAGVTAGVVAMIKANGRHLTSRPRLCHLI
InterPro domains: - IPR002013: SAC domain (domain) [65-455]
Interaction partners: - Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2B
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C
- Phosphatidylinositol 4-kinase alpha 1
- Phosphatidylinositol 4-kinase alpha 2
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase PTEN2A
- Phosphatidylinositol 4-kinase beta 2
- Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Phosphatidylinositol 4-kinase beta 1
- 1-phosphatidylinositol-3-phosphate 5-kinase FAB1B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0052744 (phosphatidylinositol monophosphate phosphatase activity), GO:0034596 (phosphatidylinositol phosphate 4-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0016049 (cell growth), GO:0021700 (developmental maturation), GO:0000902 (cell morphogenesis), GO:0099402 (plant organ development), GO:0048588 (developmental cell growth), GO:1905392 (plant organ morphogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0009826 (unidimensional cell growth), GO:0048731 (system development), GO:0071695 (anatomical structure maturation), GO:0048364 (root development), GO:0048764 (trichoblast maturation), GO:0000904 (cell morphogenesis involved in differentiation), GO:0010015 (root morphogenesis), GO:0080147 (root hair cell development), GO:0090558 (plant epidermis development), GO:0009932 (cell tip growth), GO:0090627 (plant epidermal cell differentiation), GO:0048767 (root hair elongation), GO:0022622 (root system development), GO:0048768 (root hair cell tip growth), GO:0010053 (root epidermal cell differentiation), GO:0048765 (root hair cell differentiation), GO:0010054 (trichoblast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0030427 (site of polarized growth), GO:0055044 (symplast), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0060187 (cell pole), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0035838 (growing cell tip), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031520 (plasma membrane of cell tip), GO:0043231 (intracellular membrane-bounded organelle), GO:0090406 (pollen tube), GO:0005911 (cell-cell junction)