Protein: Plasma protease C1 inhibitor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor) (Serpin G1) (P97290)
Organism: Mus musculus (Mouse)
Function: Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.
Subcellular location: Secreted.
Sequence: MASRLTPLTLLLLLLAGDRAFSDPEATSHSTQDPLEAQAKSRESFPERDDSWSPPEPTVLPSTWPTTSVAITITNDTMGKVANESFSQHSQPAAQLPTDSPGQPPLNSSSQPSTASDLPTQATTEPFCPEPLAQCSDSDRDSSEAKLSEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSYPKDFACVHQALKGFSSKGVTSVSQIFHSPDLAIRDTYVNASQSLYGSSPRVLGPDSAANLELINTWVAENTNHKIRKLLDSLPSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFYKNSMIKVPMMSSVKYPVAQFDDHTLKAKVGQLQLSHNLSFVIVVPVFPKHQLKDVEKALNPTVFKAIMKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKLEFFDFTYDLNLCGLTEDPDLQVSAMKHETVLELTESGVEAAAASAISFGRSLPIFEVQRPFLFLLWDQQHRFPVFMGRVYDPRG
InterPro domains: - IPR042178: Serpin superfamily, domain 1 (homologous_superfamily) [157-443]
- IPR000215: Serpin family (family) [146-502]
- IPR023795: Serpin, conserved site (conserved_site) [475-485]
- IPR036186: Serpin superfamily (homologous_superfamily) [134-502]
- IPR042185: Serpin superfamily, domain 2 (homologous_superfamily) [292-502]
- IPR023796: Serpin domain (domain) [150-502]
Interaction partners: - Complement C1s-1 subcomponent
- Complement C1s-1 subcomponent
- Complement C1r-B subcomponent
- Complement C1r-A subcomponent
- Mannan-binding lectin serine protease 1
- Mannan-binding lectin serine protease 2
- Mannose-binding protein A
- Complement C1q subcomponent subunit B
- Mannose-binding protein C
- Kallikrein 1-related peptidase b8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002683 (negative regulation of immune system process), GO:0048585 (negative regulation of response to stimulus), GO:0050777 (negative regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0080134 (regulation of response to stress), GO:0031348 (negative regulation of defense response), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0050728 (negative regulation of inflammatory response), GO:0050727 (regulation of inflammatory response), GO:0002862 (negative regulation of inflammatory response to antigenic stimulus), GO:0002861 (regulation of inflammatory response to antigenic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)