Protein: DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (E5KPM7)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQALCQVITTFMTFLGPHRLDQMPPEELQTSSSRLGGPPWQCI
InterPro domains: - IPR023170: Helix-hairpin-helix, base-excision DNA repair, C-terminal (homologous_superfamily) [108-317]
- IPR012904: 8-oxoguanine DNA glycosylase, N-terminal (domain) [26-141]
- IPR052054: Oxidative DNA damage repair enzyme (family) [20-317]
- IPR011257: DNA glycosylase (homologous_superfamily) [136-317]
- IPR004577: 8-oxoguanine DNA-glycosylase (family) [11-317]
- IPR003265: HhH-GPD domain (domain) [139-317]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds), GO:0004518 (nuclease activity), GO:0003677 (DNA binding), GO:0019104 (DNA N-glycosylase activity), GO:0003684 (damaged DNA binding), GO:0000702 (oxidized base lesion DNA N-glycosylase activity), GO:0004519 (endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0019439 (aromatic compound catabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0009057 (macromolecule catabolic process), GO:0090304 (nucleic acid metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0019692 (deoxyribose phosphate metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006259 (DNA metabolic process), GO:0009262 (deoxyribonucleotide metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0046434 (organophosphate catabolic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0006304 (DNA modification), GO:0046386 (deoxyribose phosphate catabolic process), GO:0009117 (nucleotide metabolic process), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:1901292 (nucleoside phosphate catabolic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0006285 (base-excision repair, AP site formation), GO:0009394 (2'-deoxyribonucleotide metabolic process), GO:0009264 (deoxyribonucleotide catabolic process), GO:0072529 (pyrimidine-containing compound catabolic process), GO:0006244 (pyrimidine nucleotide catabolic process), GO:0009219 (pyrimidine deoxyribonucleotide metabolic process), GO:0006289 (nucleotide-excision repair), GO:0009166 (nucleotide catabolic process), GO:0006195 (purine nucleotide catabolic process), GO:0009151 (purine deoxyribonucleotide metabolic process), GO:0051259 (protein complex oligomerization), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0009223 (pyrimidine deoxyribonucleotide catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0009223 (pyrimidine deoxyribonucleotide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)