Protein: Biofilm and cell wall regulator 1 (Q59U10)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor which acts as a master regulator of biofilm formation. Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis. Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 and HYR1. Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation
Subcellular location: Nucleus
Sequence: MSGTSQVLQNDSHQSQHASMAYNQRQPMMYPPPPQQQPLHSQNSLPPLPPIPAPSLPPISNNISNGNTNELNNNNQQQQQHGQPPLPPPPINANQQYYAVPPLRAPPPLNTLSSVVNSLPTLTPTLTNATHSTMSSNSSAESSASSSSNSITKPKSKRSSKGRVFQCTGYPGCNMSFTRSEHLARHKRKHTGERPFTCPYCSKNFSRLDNLRQHKQTVHAYETYLTKDNRDSKLLIERSKSKKKLKQQEKKAQQQAQLQAQAQAQAQAQVHMQQHQQNGYNFQPPYPQFHNQYYANNQYQGPQPPPPPAPQQQVPGQQQPQPQQGMPAGYLDPYRQYPPNTTFDPMALPPPPKINAHPQKPLPPLPHQMGGGQEQPSDNVSQQGLKIPDHAFTPKRRPEPLALQHSTHSNENISNEGNINANTNTNMNTVTSSITSDAVYPPPPRSATSAASLTPNLASPLSPLFHQSFSQTTLKSTPDPRGSTITNSSISIKSPMSQHFSILSGNSNYSNNTTNSLPSVSNLPHPNWGSTNGTTGSNGTSGGSYQQNSFHQRQSSVVSDFSIFSNSDNRKDIKSNWLKGVLNDDNNNNNNNNNEQQQQQLQDPKLASPAPTLPPVSSITGGGTSNGNDSMMVDNMENKNDVSQSNVIIDSNNNNGDKMVNKLNFQSIELHDNNNNNTPSIKSTHSTETIQTTMVVVNKSDPPPLSTPTTNTNTNTNSTATTNATGYVSKKPTINNLISQ
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [165-224]
- IPR051059: Transcription factor verF-like (family) [141-524]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [170-216]
Interaction partners: - Transcription activator TEC1
- Enhanced filamentous growth protein 1
- Biofilm regulator 1
- Agglutinin-like protein 3
- Agglutinin-like protein 1
- Hyphal wall protein 1
- Transcription factor ROB1
- Transcription factor NDT80
- Transcriptional repressor TUP1
- Transcriptional repressor TUP1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0044010 (single-species biofilm formation), GO:0050794 (regulation of cellular process), GO:0098743 (cell aggregation), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048522 (positive regulation of cellular process), GO:1900190 (regulation of single-species biofilm formation), GO:0009266 (response to temperature stimulus), GO:0098630 (aggregation of unicellular organisms), GO:0010035 (response to inorganic substance), GO:0104004 (cellular response to environmental stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009268 (response to pH), GO:0045785 (positive regulation of cell adhesion), GO:0090609 (single-species submerged biofilm formation), GO:0080090 (regulation of primary metabolic process), GO:0009409 (response to cold), GO:0010038 (response to metal ion), GO:0070417 (cellular response to cold), GO:0010811 (positive regulation of cell-substrate adhesion), GO:1900231 (regulation of single-species biofilm formation on inanimate substrate), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071241 (cellular response to inorganic substance), GO:0010810 (regulation of cell-substrate adhesion), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042710 (biofilm formation), GO:0010447 (response to acidic pH), GO:0051252 (regulation of RNA metabolic process), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0010468 (regulation of gene expression), GO:0071467 (cellular response to pH), GO:0071248 (cellular response to metal ion), GO:1900187 (regulation of cell adhesion involved in single-species biofilm formation), GO:0090605 (submerged biofilm formation), GO:0046688 (response to copper ion), GO:0071468 (cellular response to acidic pH), GO:2001141 (regulation of RNA biosynthetic process), GO:1900189 (positive regulation of cell adhesion involved in single-species biofilm formation), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0071280 (cellular response to copper ion), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)