Protein: Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (A5PJQ9)
Organism: Bos taurus (Bovine)
Function: Not known
Sequence: MGEAEKFHYVYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFEIVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGRWKPMDVEDSLELLSPHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQGSVSESVSNSGINSAEIDSSQIITSPLPPVSSPPSASKTKESSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [266-520]
- IPR035892: C2 domain superfamily (homologous_superfamily) [36-176]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [538-883]
- IPR015433: Phosphatidylinositol 3-/4-kinase (family) [49-883]
- IPR002420: C2 phosphatidylinositol 3-kinase-type domain (domain) [21-198]
- IPR008290: Phosphatidylinositol 3-kinase, Vps34 type (family) [1-887]
- IPR057756: Phosphatidylinositol 3-kinase type3/VPS34-like (domain) [539-883]
- IPR042236: Phosphoinositide 3-kinase, accessory (PIK) domain superfamily (homologous_superfamily) [288-532]
- IPR018936: Phosphatidylinositol 3-/4-kinase, conserved site (conserved_site) [635-748]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [687-887]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [605-884]
- IPR001263: Phosphoinositide 3-kinase, accessory (PIK) domain (domain) [283-530]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0052742 (phosphatidylinositol kinase activity), GO:0035004 (phosphatidylinositol 3-kinase activity), GO:0016303 (1-phosphatidylinositol-3-kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050793 (regulation of developmental process), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0045595 (regulation of cell differentiation), GO:0035556 (intracellular signal transduction), GO:0010720 (positive regulation of cell development), GO:1903429 (regulation of cell maturation), GO:1903431 (positive regulation of cell maturation), GO:0048017 (inositol lipid-mediated signaling), GO:0060284 (regulation of cell development), GO:0048015 (phosphatidylinositol-mediated signaling), GO:0014065 (phosphatidylinositol 3-kinase signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:1990234 (transferase complex), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005942 (phosphatidylinositol 3-kinase complex), GO:0043227 (membrane-bounded organelle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0035032 (phosphatidylinositol 3-kinase complex, class III), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle)