Protein: Ribitol-5-phosphate transferase FKTN (Q8R507)
Organism: Mus musculus (Mouse)
Function: Catalyzes the transfer of CDP-ribitol to the distal N- acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasm. Nucleus. Endoplasmic reticulum. Note=In retinal tissue, does not localize with the Golgi apparatus
Sequence: MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSARNGPGSSKSKGNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGPASECRFFCVPRDFTAFALQYHLWKNEDGWFRIAENMGFQCLKTESKDPRLDGIDSLSGTEIPLHYVCKLTTHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYIDDNTVDAMVFRKRAKELLQLAAKTLKDLGVPFWLSSGTCLGWYRQCGIIPYSKDVDLGIFIQDYKPDIILAFQEAGLPLKHKFGKVEDSLELSFQGKNDVKLDIFFFYEEADHLWNGGTQARTGKKFKYLFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKTWKIPIKTWDWKSSPPNVQPNGIWPISEWDEVIQLY
InterPro domains: - IPR007074: LicD/FKTN/FKRP, nucleotidyltransferase domain (domain) [290-328]
- IPR045587: Ribitol-5-phosphate transferase FKTN, N-terminal (domain) [1-278]
- IPR009644: FKTN/MNN4/W02B3.4-1/T07A5.1 (family) [4-460]
Interaction partners: - Ribitol 5-phosphate transferase FKRP
- Protein O-mannose kinase
- D-ribitol-5-phosphate cytidylyltransferase
- Protein O-mannosyl-transferase 2
- Protein O-mannosyl-transferase 1
- Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
- Ribitol-5-phosphate xylosyltransferase 1
- Dystroglycan 1
- Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
- UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016780 (phosphotransferase activity, for other substituted phosphate groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009058 (biosynthetic process), GO:0007275 (multicellular organism development), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0044249 (cellular biosynthetic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0061061 (muscle structure development), GO:0042127 (regulation of cell population proliferation), GO:0097502 (mannosylation), GO:0010646 (regulation of cell communication), GO:0044260 (cellular macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:1902532 (negative regulation of intracellular signal transduction), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006486 (protein glycosylation), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0009100 (glycoprotein metabolic process), GO:0035268 (protein mannosylation), GO:0034645 (cellular macromolecule biosynthetic process), GO:0007517 (muscle organ development), GO:1901137 (carbohydrate derivative biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0006493 (protein O-linked glycosylation), GO:0035269 (protein O-linked mannosylation), GO:0070303 (negative regulation of stress-activated protein kinase signaling cascade), GO:0009101 (glycoprotein biosynthetic process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0043409 (negative regulation of MAPK cascade), GO:0032873 (negative regulation of stress-activated MAPK cascade), GO:0046328 (regulation of JNK cascade), GO:0046329 (negative regulation of JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000139 (Golgi membrane)