Protein: T-cell surface antigen CD2 (LFA-2) (LFA-3 receptor) (Lymphocyte antigen 37) (Ly-37) (T-cell surface antigen T11/Leu-5) (CD antigen CD2) (P08920)
Organism: Mus musculus (Mouse)
Function: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2440689}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MKCKFLGSFFLLFSLSGKGADCRDNETIWGVLGHGITLNIPNFQMTDDIDEVRWVRRGTLVAEFKRKKPPFLISETYEVLANGSLKIKKPMMRNDSGTYNVMVYGTNGMTRLEKDLDVRILERVSKPMIHWECPNTTLTCAVLQGTDFELKLYQGETLLNSLPQKNMSYQWTNLNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLVLLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAAAQNSVALQAPPPPGHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGSGDGVSLPPPN
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [25-120]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [26-199]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [23-199]
- IPR015632: T-cell surface antigen CD2 (family) [29-122]
- IPR015631: CD2/SLAM family receptor (family) [14-262]
- IPR008424: Immunoglobulin C2-set (domain) [129-199]
Interaction partners: - Intercellular adhesion molecule 1
- T-cell surface glycoprotein CD3 epsilon chain
- T-cell surface glycoprotein CD8 alpha chain
- T-cell surface glycoprotein CD3 delta chain
- CD2 antigen cytoplasmic tail-binding protein 2
- T-cell surface glycoprotein CD3 zeta chain
- CD2-associated protein
- CD48 antigen
- T-cell surface glycoprotein CD3 gamma chain
- T-cell surface glycoprotein CD4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0098609 (cell-cell adhesion), GO:0070887 (cellular response to chemical stimulus), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0034097 (response to cytokine), GO:0034113 (heterotypic cell-cell adhesion), GO:0032677 (regulation of interleukin-8 production), GO:0071310 (cellular response to organic substance), GO:0010628 (positive regulation of gene expression), GO:0034341 (response to type II interferon), GO:0032757 (positive regulation of interleukin-8 production), GO:0010468 (regulation of gene expression), GO:0034612 (response to tumor necrosis factor), GO:0071346 (cellular response to type II interferon), GO:0071345 (cellular response to cytokine stimulus), GO:0071356 (cellular response to tumor necrosis factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)