Protein: E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68) (Q6AZZ1)
Organism: Homo sapiens (Human)
Function: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
Subcellular location: Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
Sequence: MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLCRAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEACSQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETRKQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQVLWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKTYAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYWEVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPPRRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICSLDGED
InterPro domains: - IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [31-40]
- IPR050143: Tripartite motif-containing (family) [12-478]
- IPR000315: B-box-type zinc finger (domain) [93-134]
- IPR006574: SPRY-associated (domain) [302-354]
- IPR003877: SPRY domain (domain) [355-482]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [295-480]
- IPR003879: Butyrophylin-like, SPRY domain (domain) [301-464]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [3-87]
- IPR001870: B30.2/SPRY domain (domain) [285-481]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [296-484]
- IPR042656: E3 ubiquitin-protein ligase TRIM68, RING finger, HC subclass (domain) [13-61]
- IPR001841: Zinc finger, RING-type (domain) [16-61]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019222 (regulation of metabolic process), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0048525 (negative regulation of viral process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0002683 (negative regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0065009 (regulation of molecular function), GO:0050792 (regulation of viral process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050777 (negative regulation of immune response), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0045069 (regulation of viral genome replication), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0051098 (regulation of binding), GO:0031647 (regulation of protein stability), GO:0001817 (regulation of cytokine production), GO:0043170 (macromolecule metabolic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0045787 (positive regulation of cell cycle), GO:0031348 (negative regulation of defense response), GO:0009894 (regulation of catabolic process), GO:0051726 (regulation of cell cycle), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0046782 (regulation of viral transcription), GO:0032897 (negative regulation of viral transcription), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0009615 (response to virus), GO:0009896 (positive regulation of catabolic process), GO:0032102 (negative regulation of response to external stimulus), GO:0031347 (regulation of defense response), GO:0045088 (regulation of innate immune response), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051607 (defense response to virus), GO:0051246 (regulation of protein metabolic process), GO:0062197 (cellular response to chemical stress), GO:0051248 (negative regulation of protein metabolic process), GO:0010506 (regulation of autophagy), GO:0045824 (negative regulation of innate immune response), GO:0043393 (regulation of protein binding), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0140546 (defense response to symbiont), GO:0010508 (positive regulation of autophagy), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0050821 (protein stabilization), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0031648 (protein destabilization), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0032092 (positive regulation of protein binding), GO:0030162 (regulation of proteolysis), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:2001141 (regulation of RNA biosynthetic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0006355 (regulation of DNA-templated transcription), GO:0044790 (suppression of viral release by host), GO:0032088 (negative regulation of NF-kappaB transcription factor activity), GO:0045861 (negative regulation of proteolysis), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903321 (negative regulation of protein modification by small protein conjugation or removal), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032446 (protein modification by small protein conjugation), GO:0031396 (regulation of protein ubiquitination), GO:0016567 (protein ubiquitination), GO:0051865 (protein autoubiquitination), GO:0006513 (protein monoubiquitination), GO:0000209 (protein polyubiquitination), GO:0070534 (protein K63-linked ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)