Protein: Autophagy-related protein 13 (Q5A1Z5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plays a key role in autophagy. Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (By similarity). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, plays an important role in biofilm formation and resistance to antifungal compounds such as fluconazole, itraconazole, terbinafine and caspofungin
Subcellular location: Cytoplasm. Preautophagosomal structure
Sequence: MLSDFKQQQQQKHHSHNPPNSHDDTQTKLQVAKLTQVIQKFFTKAAQIILESRAYPETSTPSLYPTKEESSKINKWFNLYMTNIPDSCKDDLKLWKGVDLTTIPPMIIETYIDLRSLPADQTLVLMDDEKHPWTVAKSRGKKQEVVLERWLIEFEPNTTDATVMVEELPLSYKQAIVLFRSIYGFTRLMPAFKVKKNLQNKLPLGNKILDGNQPISSKGRIGLSKPIINTRTNESHMTQKYFQPVHTSLGTLKISVAYRMDSEFCLHENEELLSSHFHKRDEEETKKKVSSSVSPLSSGTSLKETSTSPRKSQPPIRIQPFKVGSMSTSPPVQSPSISQPGTAPIQNQPSVPSSSLERRVSITSNKSTSNASLAAFLRNARSSTPSANNIPIINANPISGTSVPRSFSSSTGHEDSIFVNPDSASNTPRFASSFGSRASRRYSSTSIRQQTPQSDLMGQTNSVDAALSGIDADDDISDFVRMIDSKSDLRLGGGGGGGNSSVHNMSINESSYHGDALNKFQSLRSQYQQLSDSVSASLILQSRHSSRKSSLNSPAGSFDSHHHQHQQQQQQQQNQQQSQSPHTNTTSSIHSHAHSYSHSRMKDARPRSEDHQQTKFSAARRSSNISPTTAVPSSIGTPSSISSRIPHVTTIISSSDVSSTGGNRTKSAATTAIVSGMATSPSIYDYRSPRYQNVFDDDDEDDNDEEEGDREGNQLHEGRNSTESSQNQSKRIMKHIKKDEEDSEDDEDLLFTMSDMNSRNF
InterPro domains: - IPR040182: Autophagy-related protein 13 (family) [27-758]
- IPR036570: HORMA domain superfamily (homologous_superfamily) [31-267]
- IPR018731: Autophagy-related protein 13, N-terminal (domain) [38-264]
Interaction partners: - Serine/threonine-protein kinase ATG1
- Autophagy-related protein 17
- Autophagy-related protein 101
- Autophagy-related protein 11
- Autophagy-related protein 9
- Putative lipase ATG15
- Serine/threonine-protein kinase TOR
- Ubiquitin-binding TORC1 subunit
- Vacuolar protein 8
- Target of rapamycin complex subunit LST8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0019209 (kinase activator activity), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0061919 (process utilizing autophagic mechanism), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0044248 (cellular catabolic process), GO:0010570 (regulation of filamentous growth), GO:0009966 (regulation of signal transduction), GO:0032101 (regulation of response to external stimulus), GO:0045184 (establishment of protein localization), GO:0006914 (autophagy), GO:0009894 (regulation of catabolic process), GO:0009991 (response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0042594 (response to starvation), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0009896 (positive regulation of catabolic process), GO:0071705 (nitrogen compound transport), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0044804 (autophagy of nucleus), GO:0009267 (cellular response to starvation), GO:0072594 (establishment of protein localization to organelle), GO:0010506 (regulation of autophagy), GO:0000422 (autophagy of mitochondrion), GO:0071702 (organic substance transport), GO:0031331 (positive regulation of cellular catabolic process), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:0044743 (protein transmembrane import into intracellular organelle), GO:0022607 (cellular component assembly), GO:0016236 (macroautophagy), GO:0010508 (positive regulation of autophagy), GO:0031667 (response to nutrient levels), GO:0008104 (protein localization), GO:0043085 (positive regulation of catalytic activity), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0031669 (cellular response to nutrient levels), GO:0022411 (cellular component disassembly), GO:0051174 (regulation of phosphorus metabolic process), GO:0070925 (organelle assembly), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0031399 (regulation of protein modification process), GO:0034497 (protein localization to phagophore assembly site), GO:1905037 (autophagosome organization), GO:0016050 (vesicle organization), GO:0045937 (positive regulation of phosphate metabolic process), GO:1903008 (organelle disassembly), GO:0019220 (regulation of phosphate metabolic process), GO:0043549 (regulation of kinase activity), GO:0006605 (protein targeting), GO:0007033 (vacuole organization), GO:0034727 (piecemeal microautophagy of the nucleus), GO:0006623 (protein targeting to vacuole), GO:0016239 (positive regulation of macroautophagy), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0061726 (mitochondrion disassembly), GO:0045859 (regulation of protein kinase activity), GO:0000045 (autophagosome assembly), GO:0042327 (positive regulation of phosphorylation), GO:0072665 (protein localization to vacuole), GO:0045860 (positive regulation of protein kinase activity), GO:0032147 (activation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0000407 (phagophore assembly site), GO:0031090 (organelle membrane), GO:0005773 (vacuole), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:1990316 (Atg1/ULK1 kinase complex), GO:0043227 (membrane-bounded organelle), GO:0035032 (phosphatidylinositol 3-kinase complex, class III), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex)