wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cytochrome P450 71D180 (Carvacrol synthase) (EC 1.14.14.-) (Carveol synthase) (EC 1.14.14.51, EC 1.14.14.53) (Gamma-terpinene hydroxylase) (Limonene hydroxylase) (P0DO39)
Organism: Origanum vulgare (Wild marjoram)
Function: Involved in the biosynthesis of phenolic monoterpenes natural products thymol and carvacrol which have a broad range of biological activities acting as antimicrobial compounds, insecticides, antioxidants and pharmaceutical agents. Catalyzes the C2-hydroxylation of gamma-terpinene to produce carvacrol (Ref.1). Mediates also the C6-hydroxylation of (4S)-limonene and (4R)-limonene to form carveol (Ref.1).
Subcellular location: Membrane {ECO:0000255}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MDISISWVVIIVFVLSYLILMDKWRASKLPGNLPPSPPKLPVIGHLHLLRGGLPQHVLRGITQKYGAVAHLQLGEVHSVVLSSAESTKQAMKVLDPTFADRFDSIGSQIMWYNNDDMIFSRYNDHWRQIRKICVSELLSPRNVRSFGFIRQDEMARLIRVFESSEGAAINASEEISKMSCAIVCRAAFGSVLKDQGKLADLVKEALSMASGFELADLYPSSWLLNLLCVNKYRLQRMRGRLDNILDGFLEEHKVKKSGEFGGEDIVDVLYRMQKDTEMKAPITNNGIKGFIFDVFSAGTETSATTIQWALSELMKNPEKMVKAQAEVREKLKGKTNPDVADVQELKYLHSVVKETLRLHPPFPLIPRLCKEECEVTGYTIPAKTRTLVNVWSIGRDPAYWKDPDTFNPDRFDEVSRDVIGNDFELIPFGAGRRVCPGLHFGLANVEVPLAQLLYHFDYKLPSAMTAADMDMSETPGLSGPRKNPLIMIPTIHNPTS
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [27-488]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [428-437]
- IPR001128: Cytochrome P450 (family) [34-477]
- IPR002401: Cytochrome P450, E-class, group I (family) [62-458]
- IPR052306: Cytochrome P450 71D (family) [56-495]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009314 (response to radiation), GO:0009416 (response to light stimulus), GO:0014070 (response to organic cyclic compound), GO:0033993 (response to lipid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0009751 (response to salicylic acid), GO:0009411 (response to UV), GO:0010225 (response to UV-C)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Sugar ABC transporter, ATP binding protein (Q5LKX4)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Function: Not known
Sequence: MSDQPLVRMRGITKRFGGVTALQDVDLEAYSGEVLAIVGDNGAGKSTLIKILTGVYQATEGEIFLDGKRLEMSSHSDAIKVGIDAVYQTLALADHLTPANNMFLGNELTKRVLGIPMLDNRRMKSEATRILDERLGVRLRSMDVQTDSLSGGQRQAVAIARAVYHEDLRLLVMDEPTAALGPQETARTLKLIKSLRDQGLAVILISHSLDDVFEVADRVHVQRRGRAVGVVNTAQSSVQEVLGLIVGAQDAAA
InterPro domains: - IPR017871: ABC transporter-like, conserved site (conserved_site) [149-163]
- IPR050107: ABC transporter carbohydrate import ATP-binding proteins (family) [3-249]
- IPR003593: AAA+ ATPase domain (domain) [31-226]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2-243]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [7-249]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015658 (branched-chain amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015849 (organic acid transport), GO:0006865 (amino acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015803 (branched-chain amino acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: RNA binding motif protein 34 (A2A2V2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Sequence: LEGMSKRKRKRSVQEGENPDDGVRGSPPEDYRLGQVASSLFRGEHHSRGGTGRLASLFSSLEPQIQPVYVPVPKQTIKKTKRNEEEESTSQIERPLSQEPAKKVKAKKKHTNAEKKLADRESALASADLEEEIHQKQGQKRKNSQPGVKVADRKILDDTEDTVVSQRKKIQINQEEERLKNERTVFVGNLPVTCNKKIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRVDLASETSSRDKRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKFKQQNSNPRLKNVSKPKQGLNFTSKTAEGHPKSLFIGEKAVLLKTKKKGQKKSGRPKKQRKQK
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [177-348]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [170-354]
- IPR034221: RBM34, RNA recognition motif 2 (domain) [266-338]
- IPR000504: RNA recognition motif domain (domain) [183-342]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0042273 (ribosomal large subunit biogenesis), GO:0034470 (ncRNA processing), GO:0000470 (maturation of LSU-rRNA), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process), GO:0000463 (maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA))
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005694 (chromosome), GO:0005634 (nucleus)
Protein: Defective proboscis extension response 7, isoform G (A8DZ28)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MKTYNAFLNTKTKIIHVYLTNLERPFFDDISPRNVSAVVDEIAILRCRVKNKGNRTVSWMRKRDLHILTTNIYTYTGDQRFSVIHPPGSEDWDLKIDYAQPRDSGVYECQVNTEPKINLAICLQVIADNDFQDLKTKKRFYDTKSARAKILGSTEIHVKRDSTIALACSVNIHAPSVIWYHGSSVVDFDSLRGGISLETEKTDVGTTSRLMLTRASLRDSGNYTCVPNGAIPASVRVHVLTGEQPAAMQTSSAIRIRAFTAMITIISTKVLLYISSLMEHMYLRER
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [31-116]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [30-239]
- IPR007110: Immunoglobulin-like domain (domain) [25-225]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [21-237]
- IPR003598: Immunoglobulin subtype 2 (domain) [38-232]
- IPR003599: Immunoglobulin domain subtype (domain) [32-240]
- IPR037448: Zwei Ig domain protein zig-8 (family) [20-261]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0034330 (cell junction organization), GO:0050808 (synapse organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0032589 (neuron projection membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0031253 (cell projection membrane)
Protein: Candida glabrata strain CBS138 chromosome E complete sequence (Q6FVL9)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MSNPFDLLGNDVEDPQAAIPLATKEVVKKSTSSKKADVPPPSADPAKARKNKGKLSGNEGAIRDKKAGRDNNRARDVGSSATARRNNDRKMTDRHSRTGKTDSQKKINQAWGDNDRELTVEEQAKRDAESELAEDAEAPETQPAGPQKMSLADYMNQVDNNDLNKVPEARKVEETLQAEAKSDVPDYAPATKTKAVKSKQLKTKEFLQFDATFSDNNRDNRDSNRRGGFRGNSRGGRGGNRGGNRGGKSNSSRGGKNTAEVNKKIDTSSLPSLI
InterPro domains: - IPR006861: Hyaluronan/mRNA-binding protein (domain) [89-175]
- IPR039764: RNA binding protein HABP4/SERBP1-like (family) [57-272]
- IPR019084: STM1-like, N-terminal (domain) [2-53]
Interaction partners: - L21
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein uL23
- RP41
- Candida glabrata strain CBS138 chromosome M complete sequence
- Candida glabrata strain CBS138 chromosome M complete sequence
- YL17
- L17A
- 60S ribosomal protein L13
- L2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009987 (cellular process), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0042710 (biofilm formation), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Stac-like, isoform Q (A0A0B4LF79)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MGISAHAAPASFWNHPRRIRRTPTSDRDGVDQCRPWICRRKDRRPAHPAANRPPESRVCGPSSTFRWDDWAAPAPRTRERATDCARMCMCTSRIPYSVARICARTTSMHSSRPASRSSSFIRRPLTRRQRMAVGGVTRRLWRTMRVYTIHQGRGVRRARAAQAVAAYLRDRRARIGKGWPAQGHGVRISATEQWADKPVVRRPGDPTRRVAAGAVPVLAERLPKVTGSSVKSSSGRRSRRRRIFGWRGPRGGSLSPQGGSMASYNGVLKDYSHSSLNEAFKSQNNVNFKLIKTVSDFSETLSRLYEEHATALQVAVSNYRKKNAELRKERPACHLAIFQAWETFLQEVETDSQACNDVASVLSRQVSRPMLDKSFHRKVQSRKIFTHRESFETIIAKTEEKLSKCRVDYKQCHLAHRQNPSQHSLTEYIDAHNAYVQQLHATNGMLEAYHTDTLPQQMQELEEIHNDLVAIVSDSLMQGAEVIAGKANDQAKRYNSLSNQCAAVSPQQDLVNFVRLLAQPSQAQKIPRRLFASPQAEVGEEAGDHNEMTPCLRNELVFDRHSTLSQRSALESLKREAIELELQIRQLQDSIEALNRTQTRGIEGQLYNKVNELQEDLSMKKFDLRAKQIHLAAIRAQKDLFVSKVEPTSPRNERKFSAATAPSMKTKWLKAFKSLKPAGSGSAQQADRRNGASSTASEPLRPNLDGSHHLQEYTYKKITACDVCSQILRGHTRQGLRCRICKLNAHGDCAPNLPRCQPKQKLLRRQKSTSELENRVDIEEETSPQESLVAAAADQADDPSPNLNMNTNTNTITNPSANQLNVPNAKFRQKTPFMHRIAQLAGADKSVQAKQMDGSVAGGSALPVPVLSERELGRAPPPDIPIVSVSELALQEQQQQQQQQQQQHQQQQRSLASVAQAAAVRAGRGVRPPPVAMPILGVQLQQQELQQQRGGLPVPSQDISSSSASANPKSETTRPFGEPLMLLKSTESNPDESKGNRRVR
InterPro domains: - IPR046349: C1-like domain superfamily (homologous_superfamily) [699-756]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [270-520]
- IPR039688: STAC1/2/3 (family) [435-974]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [707-756]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0071840 (cellular component organization or biogenesis), GO:0090066 (regulation of anatomical structure size), GO:0016043 (cellular component organization), GO:0032535 (regulation of cellular component size), GO:0008361 (regulation of cell size), GO:0045793 (positive regulation of cell size)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0031594 (neuromuscular junction)
Protein: Oxidoreductase, short chain dehydrogenase/reductase family (AFU_orthologue AFUA_5G11240) (C8VUY4)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MFFNRAYHQSIAVLRQFASPYPRISAFPRPLTSVLGSSFRRTMASAMAKRLEGKTIVITGASSGIGRSTAREFARTAPKDLKLIVTARRIDALEELAKEIKEEVGEGVKTLPVKLDVSNPEEVKNFVPSLPAEFQDIDILVNNAGLVKGVAQAPNIDPEDINIMFATNVTGLINLTQAVLPIFKKRSDGGRGDIINIGSIAGREPYPGGSIYCSTKAAVKSFTEALRKELISTRIRVIEIDPGQVETEFSIVRFYGDKSKANAVYANCEPLTPDDIAEVIVFAAGRRENVVIADTLIFPSHQASPGHLYKKPQ
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [52-288]
- IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [199-227]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [54-286]
Interaction partners: - Oxidoreductase
- Threonine aldolase or alanine racemase, putative
- Threonine aldolase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: RNA helicase (EC 3.6.4.13) (Q56TY6)
Organism: Trypanosoma brucei
Function: Not known
Sequence: MLSKRNREGSRGAMGCGEKNPYTGRVLSSRYHALRGVREKLPIFAAKQKIQRLISRYQTLLLVGETGSGKTTQVPQFVLEMNPEHAIACTQPRRVAAISVSERVAEELDVTLGEEVGYCIRFDDTSSDRTRLKYLTDGMLLREAMGDPMLQRYSVIILDEAHERTVHTDILIGAVKDLLHRRPDLRVVVMSATLEERRFQSYFPEAPLVHVSGRMYDVEVYNSRLPEANYLEASIRTAMQIHLYEGPGDILIFLTGEDEIEQAVERLRLGIPMAEHTNADCHKGPVAVLPLYSALPPKEQRKVFQAAPEGTRKIVVATNVAETSLTIDGVVFVIDSGFSKQKVYNPKLRVESLLVTPISQASARQRCGRAGRTRPGKCFRLYTAKAFDTLLQQQTYPEILRCNLGSVILHMKMMGIEDLVNFDFVEPPAPETLMRALELLNYLGAINDDGDMTKFGRRVADFPLEPEMAAMLLHSPEYGCSDDIARICAMMSVQSPFVTPRNDQRGCAMRCRDQFYHPTGDHLALLNVFNAFYEGSNQSGSWASENYLNPRVMKQSVSIYRQLIGIMRRLNLSICSTYSAAQWGGAGDGESDEYANEVRRAVLRGYFTKVALSLPTKNQFLTLKDNVKCLLFPSTFLNRRPKFVVFNELVLTTNTYIRTVTSVSDEWLLEVNPLYFDPSEFEGVSRQVFEELHRRNNRNNAAERDQNKDCLTGHKRRRGGDAPDNGDDDDDDDSS
InterPro domains: - IPR011709: DEAD-box helicase, OB fold (domain) [598-673]
- IPR003593: AAA+ ATPase domain (domain) [56-226]
- IPR002464: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (conserved_site) [154-163]
- IPR007502: Helicase-associated domain (domain) [435-526]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3-571]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [40-221]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [56-195]
- IPR048333: Helicase associated domain (HA2), winged-helix domain (domain) [436-464]
- IPR001650: Helicase, C-terminal domain-like (domain) [238-415]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Multidrug transporter AQR1 (Drug:H(+) antiporter AQR1) (DHA AQR1) (Flucytosine exporter AQR1) (Q6FNQ2)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Multidrug transporter acts as a determinant of resistance to acetic acid, flucytosine and clotrimazole, these 3 compounds acting synergistically against the pathogen. Reduces the intracellular accumulation of the antifungal agents flucytosine and, to a moderate extent, of clotrimazole. Its role in acetic acid resistance may be indirect, presumably through the transport of a still unidentified physiological substrate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23805133}; Multi-pass membrane protein {ECO:0000255}. Note=Also localizes to membrane vesicles (PubMed:23805133). {ECO:0000269|PubMed:23805133}.
Sequence: MVESGPHSINDDLSTNEYIEQPKFYHDDHASDSNSLSDIDDDNKKHGGLYGTVSRTTTRELPEDLESEISSTHSQDAKEDLEIQHNAAPYSLLNYRDKWCMVALLTACGFWSSLGSPIYYPALKQLEKQFDIDENMVNITVVVYLLFQGLAPTCSGGLADKFGRRPVLLIGMLIYVVASIGLACAPSYGVIVFLRCVQSIGISPSIAISSGVVGDFTVKSERGTFVGATSGFVLLGQAFGSLIGAALAAAWDWRAIFWFLTIGCGASFAICFALLPETKRSIVGNLSIRPKNPLNIAPVTLLPAARRKLKYDNPDYETLDKTKPVFDLTSAFKICALPEIFLSLLPPGLAFAMWTLMLSAISSELSAAPYNYKLTIIGVCYLPAGIGGLIGSFATGKIIDFQYKKKLKVFEEKKAAGIIPEDEKFNIMGARLQSVLPQNFLCVVTYILFGWSCDKGWKIPSILITSCVSSFCAMSTLSAMSTLLVDLYPGKSSTASSCFNFMRCSLSAILMGCFAKMKHSLTVGGTFTLLAGLVFVGNFLMFIPMKHGMRWREEREQRAALKAKSMDQANENGYKLFSKIKFSSPFKSEEKV
InterPro domains: - IPR011701: Major facilitator superfamily (family) [107-509]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [84-557]
- IPR005829: Sugar transporter, conserved site (conserved_site) [155-171]
- IPR020846: Major facilitator superfamily domain (domain) [101-549]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0042910 (xenobiotic transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0140352 (export from cell), GO:0140115 (export across plasma membrane), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)