Protein: Platelet derived growth factor receptor beta (E5RJ14)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQ
InterPro domains: - IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [9-46]
- IPR042495: Platelet-derived growth factor receptor-like protein (family) [15-133]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-146]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0003008 (system process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0003013 (circulatory system process), GO:0010632 (regulation of epithelial cell migration), GO:0009887 (animal organ morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0001568 (blood vessel development), GO:0050920 (regulation of chemotaxis), GO:0006952 (defense response), GO:0031324 (negative regulation of cellular metabolic process), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0001525 (angiogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0050921 (positive regulation of chemotaxis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0008015 (blood circulation), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0001944 (vasculature development), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030334 (regulation of cell migration), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0003007 (heart morphogenesis), GO:0010594 (regulation of endothelial cell migration), GO:0072359 (circulatory system development), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0019221 (cytokine-mediated signaling pathway), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0072001 (renal system development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process), GO:1901342 (regulation of vasculature development), GO:0010628 (positive regulation of gene expression), GO:1902532 (negative regulation of intracellular signal transduction), GO:0030334 (regulation of cell migration), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0006954 (inflammatory response), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0031326 (regulation of cellular biosynthetic process), GO:0010634 (positive regulation of epithelial cell migration), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0045765 (regulation of angiogenesis), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051897 (positive regulation of protein kinase B signaling), GO:0043537 (negative regulation of blood vessel endothelial cell migration), GO:0060390 (regulation of SMAD protein signal transduction), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0051896 (regulation of protein kinase B signaling), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0051896 (regulation of protein kinase B signaling), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0031401 (positive regulation of protein modification process), GO:0043408 (regulation of MAPK cascade), GO:0001938 (positive regulation of endothelial cell proliferation), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0043066 (negative regulation of apoptotic process), GO:0010595 (positive regulation of endothelial cell migration), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:2000278 (regulation of DNA biosynthetic process), GO:0050954 (sensory perception of mechanical stimulus), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0043536 (positive regulation of blood vessel endothelial cell migration), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0090049 (regulation of cell migration involved in sprouting angiogenesis), GO:0048010 (vascular endothelial growth factor receptor signaling pathway), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)