Protein: Suppressor of ferric uptake 1 (Q5AP95)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional regulator of iron-responsive genes. Represses expression of SEF1 and genes for iron uptake if iron is present. Plays also a transcription-independent role in the direct inhibition of SEF1 function through protein complex formation and translocation to the cytoplasm, where SEF1 is destabilized. Promotes gastrointestinal commensalism in mice
Subcellular location: Cytoplasm. Nucleus
Sequence: MPTSPTESIPNSSTKEQPILPKMLPTAKSPHTTPAQSPQNSDHHHHHQQTPPQPTDGQQCSNCGTTKTPLWRRAPDGTLICNACGLYYRSNNTHRPVNLKRPPNTIAVVKEEEGSCKGDGRCNGTGGSAACKGCPAYNNRIVAKKALEKSPKNDSSRAPIDKSLKRSTSTDATTEDESSLAIACFNCGTTITPLWRRDDAGNTICNACGLFYRLHGSHRPIKMKRPTIKRRKRNVSDKKSKDEVQMHSSDQSPIVASDPISPTPHNNENNNNVTNITTTTKTPTRSPHYYQPPPQYPYQHHPINSTTSSAINRLPPISYQSPYQTAPLSHSPMQSSSSYSPGASSVIPSSYYPPYSGSGRIPNGPGPVPGPPPPPPPTQSQPHHQQITTSPTSQSYGSLRAPIHITKRGYTPENIRLPSIQLTSSTSSNSETKLPPITNHSEKCCSNCAGPKSLAPMAIDFTASYRFNNIDSQTKLTKEDQNDSEGVSRDNDTRDENKPIKQEEHRSALSIGKLLNG
InterPro domains: - IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [53-237]
- IPR039355: Transcription factor GATA (family) [124-404]
- IPR000679: Zinc finger, GATA-type (domain) [54-233]
Interaction partners: - Hap43p
- Transcriptional regulatory protein SEF1
- Hap5p
- Transcriptional regulator EFH1
- Monothiol glutaredoxin
- Transcriptional activator HAP2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0030447 (filamentous growth), GO:0035821 (modulation of process of another organism), GO:0048523 (negative regulation of cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0007154 (cell communication), GO:0051701 (biological process involved in interaction with host), GO:0009991 (response to extracellular stimulus), GO:0055082 (intracellular chemical homeostasis), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0075136 (response to host), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0098771 (inorganic ion homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0055072 (iron ion homeostasis), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0052572 (response to host immune response), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)