Protein: 6-phosphogluconate dehydrogenase, decarboxylating 1 (EC 1.1.1.44) (P38720)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}.
Sequence: MSADFGLIGLAVMGQNLILNAADHGFTVCAYNRTQSKVDHFLANEAKGKSIIGATSIEDFISKLKRPRKVMLLVKAGAPVDALINQIVPLLEKGDIIIDGGNSHFPDSNRRYEELKKKGILFVGSGVSGGEEGARYGPSLMPGGSEEAWPHIKNIFQSISAKSDGEPCCEWVGPAGAGHYVKMVHNGIEYGDMQLICEAYDIMKRLGGFTDKEISDVFAKWNNGVLDSFLVEITRDILKFDDVDGKPLVEKIMDTAGQKGTGKWTAINALDLGMPVTLIGEAVFARCLSALKNERIRASKVLPGPEVPKDAVKDREQFVDDLEQALYASKIISYAQGFMLIREAAATYGWKLNNPAIALMWRGGCIIRSVFLGQITKAYREEPDLENLLFNKFFADAVTKAQSGWRKSIALATTYGIPTPAFSTALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPECASDNLPVDKDIHINWTGHGGNVSSSTYQA
InterPro domains: - IPR008927: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily (homologous_superfamily) [176-479]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [3-175]
- IPR006115: 6-phosphogluconate dehydrogenase, NADP-binding (domain) [5-171]
- IPR006183: 6-phosphogluconate dehydrogenase (family) [3-488]
- IPR006113: 6-phosphogluconate dehydrogenase, decarboxylating (family) [1-484]
- IPR013328: 6-phosphogluconate dehydrogenase, domain 2 (homologous_superfamily) [180-435]
- IPR006114: 6-phosphogluconate dehydrogenase, C-terminal (domain) [178-476]
- IPR006184: 6-phosphogluconate-binding site (binding_site) [252-264]
Interaction partners: - Glucose-6-phosphate 1-dehydrogenase
- 6-phosphogluconolactonase 3
- Ribulose-phosphate 3-epimerase
- Probable gluconokinase
- 6-phosphogluconolactonase 4
- 6-phosphogluconate dehydrogenase, decarboxylating 2
- Transketolase 1
- Ribose-5-phosphate isomerase
- 6-phosphogluconolactonase-like protein 1
- 6-phosphogluconolactonase-like protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006740 (NADPH regeneration), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0051156 (glucose 6-phosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0006098 (pentose-phosphate shunt), GO:0009051 (pentose-phosphate shunt, oxidative branch), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0006739 (NADP metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)