wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Receptor-transporting protein 5 (3CxxC-type zinc finger protein 5) (CXXC-type zinc finger protein 11) (Q14D33)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MDRAGADMWASTFTLAMAERKPQDVWVLLPEHSLVPGCLDGGGVQYLLVGLSRLQCGHCPGTWDSAHVHVLFHLWWDRASHRGLVKMRIWGQRCRLCPAPGDCQVRPPGEQPFLSRLVLHILQDCYGDGPGPARHPREAYEGCCEACELGVCFLQKAPDPAWSANATKGNFPATAWGGTGTVSRGKPLSTPGDDLGKGGVVIAIPFSLVGTSNDQVPIAEGPAPPAGASLPVTGSCEALVIGQGSIFLSGDSVAMPGGKGFPVAIGDPLFHGPGLLGSSIQTFELKGFLFKGRGSLCSPVGVAQGWGPISLNNGLVPVGKHTPTVFYCVGLSASGEGSLTFPSSLTSIFTNTLSEPTDGPVATKEASITFPFIFTDVKDAVAEVAEGNGKEGGGQGLVPVGHDALPETNAGGLPSQVKGSLALPFPADVQGKDAFTDITEGKEKEGGLVTAGHDAPLEANAEGPITVSEGCITIPFAVFDVIKRKGGGHVAYGPQGNGCFSQGYYQKRQLRSRFHKARCGCRREEDERPGRACRRPHAEPYEDFWIWVSMTVCVFWLMCMCRLNPGIYPQQV
InterPro domains: - IPR027377: ZAR1/RTP1-5-like, 3CxxC-type zinc finger (domain) [49-150]
- IPR026096: Receptor-transporting protein (family) [2-568]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0090150 (establishment of protein localization to membrane), GO:0072657 (protein localization to membrane), GO:0006612 (protein targeting to membrane), GO:0006605 (protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Uncharacterized protein AT4g03830 (Q9M107)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MPPKRIQREVYSIDGQFGTYTSSQSTSRRLSLLKGAHGIPGRINLISPEATDSPETPSPGHACAFEIFFSECGLYFPLPDILIDFMHEFGIALPQLCPNVIRTILSLLTLAEEDNFLLSLPDLLQLYAIKKGRTQGTFFLSPRKGFRVFEDFPEKDEQWRKSFFFFRVNELTFGEKTGLFVSEWSARAASVDLLPISKTFASHFSSFVRQDLGWESLSSDRVRASGKRLRSRTDLAISSPPFEPRIFSEEEMSAPSYRAEKKMERERAKQEKDRLKSDKVVMTGTLEDSKLQAANKAKQPRAEEDGGARQKPSTLASKNDAPAPDSRTPSKATSSRDPSKRYGDKKRKQSDKDARSPARSVRVRTEERDASPSQQKEKGKKGDSQDLVKSIPLNAPFLRDTDNLLSSGHVSAPPLPFADLVRSFTHAGAPIPPLKELKPTNQENYLRFAEKLGELSDKDREIESFKQNEEENSRMVDRANSVLSRMREAEARVLALDIANTDLAAKLESGKNAYLAAIDNENRARAELLACEEKLRKLEEGQAALLADARREERRKVRAQFKDFTSKYQSFYAESEEV
InterPro domains: - IPR006736: Protein of unknown function DUF601 (family) [282-578]
Interaction partners: - Protein phosphatase EYA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019080 (viral gene expression), GO:0019083 (viral transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0055044 (symplast), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction)
Protein: eRF1 methyltransferase catalytic subunit MTQ2 (eRF1 MTase catalytic subunit MTQ2) (EC 2.1.1.297) (N(5)-glutamine methyltransferase MTQ2) (Q03920)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Sequence: MLPTPYVKCDYDKVYEPAEDSFLILDCLEKEHDFLKQKFGNRLAIVCEIGSGSGIVTTFLMQNKIIPQENSIHLAVDINPWALEATLDTAKLNSCKSSFLEVIQADLNSSIRNNQVDVLIFNPPYVPAECVPDVPGSREEADQWLDLALLGGKDGMAITDKLLRQLEQILSPDGVAYILFCARNKPKEVIKRFVDTYKWNVKLIETRKAGWEVLSVYSFTR
InterPro domains: - IPR002052: DNA methylase, N-6 adenine-specific, conserved site (conserved_site) [119-125]
- IPR004557: Eukaryotic/archaeal PrmC-related (family) [14-212]
- IPR052190: Eukaryotic/Archaeal PrmC-Related Methyltransferase (family) [10-221]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [12-221]
- IPR007848: Methyltransferase small domain (domain) [35-125]
Interaction partners: - Multifunctional methyltransferase subunit TRM112
- tRNA
- Eukaryotic peptide chain release factor subunit 1
- Mitochondrial MRF1 N
- 18S rRNA
- Peptide chain release factor 1, mitochondrial
- Uncharacterized peptide chain release factor-like protein YLR281C
- tRNA
- tRNA
- tRNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0008213 (protein alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Riboflavin transporter (Q8SYL6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368035}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368035}.
Sequence: MSRYHRGRGAGSPTNPAGPVYGVISTLDDATPSPADFARCSSLEAKKSELSLFLNWGGPQKNMEISSKLRNRSWLVDVLAIFFGIGTWLGVNGTFIQLPLLVDEAPEGWGLPSYLSVMVQIGNLGPLLYTAIQKYSPKKLNDGWTIHGVLLVRAISCLLTAFFYNQTASVAGTDHSLALFLLTCFTALNACTSSVLFMPYMGRFKEQYMVTYFIGEGLSGLLPSVTALIQGIGESGDCVLVNVTESGEEVYALRKTPPRFDTRVFFLILFALMVLAYVGYALLNSLPLARREYAQVTVSEGNKYVYGEADNQPKAEKLSKGQYTYLLLLIGAISLFSNGMFGSIQSYSSAPYGSQAYHLAATLSVIANPVACFMAMFLHLPPCGLSRCSLSLRVC
InterPro domains: - IPR009357: Solute carrier family 52, riboflavin transporter (family) [68-380]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0090482 (vitamin transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0032217 (riboflavin transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051180 (vitamin transport), GO:0071705 (nitrogen compound transport), GO:0015711 (organic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Myofilin, isoform O (A0A0B4KG65)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MFKNHLEMIGRNESPSKKAKFWQSYIRSLKGSEDIRAHEAPRASRPYSSYLDSPSYRSIYDEPATANERVQSSGYRYLPVSRDTYGYSPRAIYDHHYSRTTNYDAEKAWNDHLKRMQEIERRYPSRYGLYLRDKPLTPNSLVPLEYEPEDKLLAELNKARRSASPFRPARTTRAGSEPYVPPPSYWNREGSVPRGGPSVFDRATSLAPFTRPSFRASSLEPLDELFERLPIFHPRNRFRDLLSPSPNLPISSIVRDPFWWDVDDLVPFRATSVPRASSPVARDSYLSPVKNRYLWSKHPARPLTPHRSIL
InterPro domains: - IPR031828: Myofilin (family) [1-131]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0017022 (myosin binding), GO:0032036 (myosin heavy chain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0007498 (mesoderm development), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0051146 (striated muscle cell differentiation), GO:0055002 (striated muscle cell development), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030017 (sarcomere), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031672 (A band), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043292 (contractile fiber), GO:0043228 (non-membrane-bounded organelle), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber)
Protein: Tubulin beta chain (A0A1D8PC97)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MREIIHLSTGQCGNQIGAAFWETICGEHGLDNNGTYVGNNELQKSKLDVYFNEATSGKYVPRAVLVDLEPGTIDNVKTSQIGNLFRPDNFIFGQSSAGNVWAKGHYTEGAELVDSVLDVVRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVIEPYNATLSVHQLVENSDETFCIDNEALYNICQNTLKLPQPSYAELNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTSMGSKSFRSVTVPELTQQMFDAKNMMAASDPRNGRYLTVAAFFRGKVSVKEVDDEMHKIQTRNSSYFVDWIPNNVQTAVCSVPPKDLDMSATFIGNSTSIQELFKRVGDQFSAMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVSEYQQYQEASIDEEELEYADEIPLEDAAME
InterPro domains: - IPR036525: Tubulin/FtsZ, GTPase domain superfamily (homologous_superfamily) [1-262]
- IPR023123: Tubulin, C-terminal (homologous_superfamily) [374-430]
- IPR008280: Tubulin/FtsZ, C-terminal (homologous_superfamily) [244-429]
- IPR018316: Tubulin/FtsZ, 2-layer sandwich domain (domain) [246-383]
- IPR000217: Tubulin (family) [3-427]
- IPR002453: Beta tubulin (family) [41-430]
- IPR017975: Tubulin, conserved site (conserved_site) [140-146]
- IPR013838: Beta tubulin, autoregulation binding site (binding_site) [1-4]
- IPR003008: Tubulin/FtsZ, GTPase domain (domain) [3-244]
- IPR037103: Tubulin/FtsZ-like, C-terminal domain (homologous_superfamily) [263-373]
Interaction partners: - Dynein heavy chain, cytoplasmic
- Tubulin alpha chain
- Calmodulin
- Kinesin-like protein
- Uncharacterized protein
- Actin
- TOG domain-containing protein
- Mlc2p
- Microtubule-binding protein
- Spindle assembly checkpoint component MAD2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0005881 (cytoplasmic microtubule), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005819 (spindle), GO:0005874 (microtubule), GO:0005876 (spindle microtubule), GO:0015630 (microtubule cytoskeleton)
Protein: Muscleblind like splicing regulator 1 (C9JCX1)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKI
InterPro domains: - IPR000571: Zinc finger, CCCH-type (domain) [87-149]
- IPR054429: Muscleblind-like, CCCH zinc finger (domain) [124-155]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0045596 (negative regulation of cell differentiation), GO:0045661 (regulation of myoblast differentiation), GO:0045662 (negative regulation of myoblast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: 17beta-hydroxysteroid dehydrogenase type 10/short chain L-3-hydroxyacyl-CoA dehydrogenase (Hydroxysteroid (17-beta) dehydrogenase 10) (Q99N15)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MAAAVRSVKGLVAVVTGGASGLGLATAKRLVGQGATAVLLDVPDSEGEAQAKKLGESCIFAPANVTSEKEIQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHQKKNKIHTLEDFQRVINVNLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPTGIRVVTIAPGLFATPLLTTLPEKVRNFLASQVPFPSRLGDPAEYAHLVQTIIENPFLNGEVIRLDGAIRMQP
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [8-257]
- IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [155-183]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [12-243]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0098798 (mitochondrial protein-containing complex), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0003857 (3-hydroxyacyl-CoA dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003006 (developmental process involved in reproduction), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0061458 (reproductive system development), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0008584 (male gonad development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0009295 (nucleoid), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0042645 (mitochondrial nucleoid), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Thioredoxin-1 (Trx-1) (P29445)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Sequence: MSNRVIHVSSCEELDKHLRDERVVVDFSAVWCGPCRAISPVFEKLSNEFITFTFLHVDIDKLNVHPIVSKIKSVPTFHFYRNGSKVSEFSGASESILRSTLEANK
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [3-102]
- IPR017937: Thioredoxin, conserved site (conserved_site) [24-42]
- IPR013766: Thioredoxin domain (domain) [1-105]
- IPR005746: Thioredoxin (family) [3-105]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0019725 (cellular homeostasis), GO:0045454 (cell redox homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SST1) (SRIF-2) (P30872)
Organism: Homo sapiens (Human)
Function: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
InterPro domains: - IPR000586: Somatostatin receptor family (family) [57-337]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [75-323]
- IPR001116: Somatostatin receptor 1 (family) [17-380]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [60-338]
Interaction partners: - Somatostatin
- Cortistatin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Neuropeptide Y receptor type 5
- Pro-neuropeptide Y
- Somatostatin receptor type 5
- Appetite-regulating hormone
- Pro-opiomelanocortin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008188 (neuropeptide receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0007187 (G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)