Protein: Nuclear receptor coactivator 3 (F1QMV7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MSGVGENSLEPLCSDRKRKLSTCDTPGQGCDKRRREQESKYIEELAELISANLSDIDSFNVKPDKCAILKETVRQIRQIKEQGKSSCGDDDVQKADVSSTGQGVIDKDHLGPLLLQALDGFLFVVSREGSIVFVSDNVTQYLQYKQEELINTSIYNILHEEDREELHKNLPKSNGPNSVSWGGDSSRQKSHTFNCRMLVKFGHGGPGGEEGAGGPRYETMQCFALTQPKAMMEEGEDLQSCMICVARRVTAVERTERFSTRHELSGKLIEIEQQSLLHTTMRPGWEDLVRRCMQMFLHRSEGQPWSYKRHYHEAYVHGRAETPPYRFSLSDGTPVTAQTRSELCRNPVTSDPHTFLSTHLLQREQNGYRPNQGGVMRSVMGNANPNAQMGMGNTRGYGMNEQGHMGPRGGAMYGPGNRMNQMNPMHQMNQMNQMNSMNQMNMNQMNCMNQMGSMNQMNQMNQMNSMNQMGHPGMNQHQQGQFHGGGGYGMVMTSPSQGSPGMNPGQQNLMGSPRIRGSPKMGASPFSPGGMHSPMGPVGMGGSSGSSGPSVGNTFSSSSLNALQAISEGVGSSLPSALNSPAHKSDSSPNINSTQSSQQGPIGNNKPITSDSKSPSSAHSTGLDQQQASSTENTDKPDSQSNKDGSAGGEVNRRVPDGKGHKKLLQLLTSPTEEIGIGTATSGPVPGRASTPMGSDPKETGSGMMSPSSTGVSSSSGSSSGNNVNQQSSGGVSSTACPSGHHSTHTLQEKHKILHKLLQNGNTPDDVARITAEATGKSSLSSEHPGAEGRNLELKQEQHSPKEGKKPQALLHYLLNKDDSKEPGATEVKPKLEELEARGASGGQGAGVTTSSSSNQESKVKLEQPDELESLESILGGLRNPGPGMFVDSGSGGSEVGNKQGNGPNSTAHDREGVGMGSGQRVPFQRAVSVDGKPMSGPGMTGRKSAPSSLVKQEHTDSQIGMGGPNRLMGMPNRPPMAGAGDWMSSSGSPAGSVGHPGMGRPGMDHNPKSMMGGPMVSRSNSVPATRSMLQQQLMEMGPYDVGMGMNSFRGQAPPPQSPSWPDSGMGMEGPPSANRLPINSPLDELLAPPSTSEGQSDERALLDQLDSLLNNTDVIALEEIDRALGIPDLINQGHSSDQPPPSDPFSGPCLGPDSSMGMEPPKAMYGQGYPGPPSMGMQGGYGPGPNPGAGPGPGPMQGQSGPGFNPMMSQMNQQGGFPGMGGMGPMHPRANMMRNRVPQAKPLRLQLQQRLQGQQFLNQSRQAMGMRPDASPAGNPGMRPSMQPGMGGQPGFLNAQMMAQRSREMLNLQTEMRRQRMMMMMQQQQQQQQQVAAGGFSPPPNVTAPTGMDNPMAGPPMSQPGQQAFNYGGNYGIGQQGDPSFVGTGSSPPNNMMSGRMGGPQNPMMQQHPQSNPMYQSAEMKGWGQGPMPMNNSYPQQQQYPQQGAPGQYGGMMMNGSMQGGVNGNGAGQMPPMQGQMGMNTMGMGRMPMGPDQKYC
InterPro domains: - IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [31-118]
- IPR017426: Nuclear receptor coactivator (family) [1-1373]
- IPR035965: PAS domain superfamily (homologous_superfamily) [118-361]
- IPR032565: Nuclear receptor coactivator 2/3, DUF4927 (domain) [795-880]
- IPR013767: PAS fold (domain) [113-169]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [22-85]
- IPR010011: Nuclear receptor coactivator, DUF1518 (domain) [1348-1406]
- IPR014920: Nuclear receptor coactivator, Ncoa-type, interlocking (domain) [1094-1139]
- IPR009110: Nuclear receptor coactivator, interlocking (homologous_superfamily) [1090-1138]
- IPR000014: PAS domain (domain) [109-175]
- IPR014935: Nuclear receptor coactivator, receptor-binding domain (domain) [659-773]
- IPR037077: Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily (homologous_superfamily) [1090-1145]
- IPR056193: Nuclear receptor coactivator 1-3, bHLH domain (domain) [1-76]
Interaction partners: - Estrogen receptor
- Nuclear receptor subfamily 5 group A member 2
- ETS translocation variant 4
- Androgen receptor
- Histone-arginine methyltransferase CARM1
- Nuclear receptor subfamily 1, group H, member 3
- Zinc finger protein 217
- Glucocorticoid receptor
- Nuclear receptor subfamily 1 group I member 2
- Mitogen-activated protein kinase 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0030097 (hemopoiesis), GO:0048568 (embryonic organ development), GO:0002521 (leukocyte differentiation), GO:0030099 (myeloid cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0002573 (myeloid leukocyte differentiation), GO:0043009 (chordate embryonic development), GO:0035162 (embryonic hemopoiesis), GO:0030851 (granulocyte differentiation), GO:0060215 (primitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)