Protein: Netrin-1 (F1QUK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MIRILVTCVSMVSITSMVSGARGGYGMSMFAAQSSPPDPCYDENGNPRRCIPDFVNSAFGKDVRVSSTCGSPPSRYCVVTEKGEERSRDCNICDATDPKKTHPPAYLTDLNNPHNLTCWQSENYVQYPQNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIFKSMDYGKTWVPFQFYSTQCKKMYNKPSKAAITKQNEQEAICTDSHTDMQPLTGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIKVTFNRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHASKCVKDREGNLVCECKHNTAGPECDRCKPFHYDRPWQRATAREANECVACHCNLHARRCRFNMELYKLSGRRSGGVCLNCRHNTAGRHCHYCKEGYYRDMSKAISHRRACKACDCHPVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAAPTSSYSSPDGPTDCDSHCKAPKGKMKVTMKKYCKKDFAVQVHVLKGDKAGEWWKFTINIISVYKQGGHRIRRGDQLLWVRAKDVACKCPKIKPGRKYLLMGSDEEEDSRGQSGVVADRGSLLIPWKDLWARRLRKFQQRDKRGKC
InterPro domains: - IPR008993: Tissue inhibitor of metalloproteinases-like, OB-fold (homologous_superfamily) [467-602]
- IPR001134: Netrin domain (domain) [471-602]
- IPR018933: Netrin module, non-TIMP type (domain) [486-596]
- IPR050440: Laminin/Netrin Extracellular Matrix (family) [37-474]
- IPR002049: Laminin-type EGF domain (domain) [283-452]
- IPR008211: Laminin, N-terminal (domain) [44-283]
- IPR056863: Laminin/attractin/netrin-like, EGF domain (domain) [284-389]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [93-174]
Interaction partners: - Neogenin
- Unc-5 netrin receptor B.
- Neogenin 1b
- Netrin receptor UNC5
- Slit homolog 1b
- Si:ch73-72b7.1.
- Draxin
- Unc-5 netrin receptor C.
- Slit homolog 1a
- Cell adhesion molecule DSCAM
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0032989 (cellular component morphogenesis), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0021537 (telencephalon development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0001558 (regulation of cell growth), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0000902 (cell morphogenesis), GO:0010941 (regulation of cell death), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0016358 (dendrite development), GO:0030900 (forebrain development), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0032535 (regulation of cellular component size), GO:0030030 (cell projection organization), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:2001233 (regulation of apoptotic signaling pathway), GO:0048666 (neuron development), GO:0061387 (regulation of extent of cell growth), GO:0007420 (brain development), GO:1901099 (negative regulation of signal transduction in absence of ligand), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0030516 (regulation of axon extension), GO:0007417 (central nervous system development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0042981 (regulation of apoptotic process), GO:2001239 (regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:0021953 (central nervous system neuron differentiation), GO:0043066 (negative regulation of apoptotic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway), GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:0021954 (central nervous system neuron development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0021955 (central nervous system neuron axonogenesis), GO:0007409 (axonogenesis), GO:0021952 (central nervous system projection neuron axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0005604 (basement membrane)