wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Oligopeptide/dipeptide uptake family ABC transporter, permease protein (Q5LMM7)
Organism: Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) (Silicibacter pomeroyi)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU363032}.
Sequence: MGAYILRRLLLVIPTLLGIMLVNFVLVQFVPGGPVDQAIAQLQGGGDVFESFAGQGNDAQLNSQTNAVNDSYIGARGLPPEFIKELEELYGLDKPAHERFLMMLWNYMTLDFGESYFRKIDVVDLVLEKMPVSITLGLWSTLIAYAISIPLGIRKAVRDGSRFDTWTSGLIIAAYAIPGFLFAILLLVLFAGGSYWQIFPLRGLTSDNFSDLSLLGKVLDYFWHIALPLTAYTIGAFTTLTLLTKNSFLDEIKKQYVITARAKGLSESRVLYGHVFRNAMLIVISGFPGVFLSVFLGGSLIIETIFSLDGLGRLGFEATVARDYPVMFGTLFVFGLIGLLVGILSDLTYVLVDPRIDFERREG
InterPro domains: - IPR035906: MetI-like superfamily (homologous_superfamily) [120-349]
- IPR000515: ABC transporter type 1, transmembrane domain MetI-like (domain) [130-356]
Interaction partners: - Oligopeptide/dipeptide uptake family ABC transporter, permease protein
- Oligopeptide/dipeptide uptake family ABC transporter, periplasmic substrate-binding protein
- Oligopeptide/dipeptide uptake family ABC transporter, ATP-binding protein
- ABC transporter, periplasmic substrate-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0042887 (amide transmembrane transporter activity), GO:1904680 (peptide transmembrane transporter activity), GO:0035673 (oligopeptide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015833 (peptide transport), GO:0042886 (amide transport), GO:0006857 (oligopeptide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cell division cycle 14A (A0A2R8Y6L0)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPCSCLLLVFRKPFLGSPLLSLPISHL
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [1-285]
- IPR050561: Protein Tyrosine Phosphatase (family) [27-459]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [203-265]
- IPR020422: Dual specificity protein phosphatase domain (domain) [121-278]
- IPR044506: Dual-specificity phosphatase CDC14, C-terminal (domain) [105-278]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [180-273]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [218-228]
- IPR029260: Dual specificity/tyrosine protein phosphatase, N-terminal (domain) [1-96]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0050954 (sensory perception of mechanical stimulus), GO:0007605 (sensory perception of sound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Long-chain N-acyl amino acid synthase (Q8KNZ7)
Organism: uncultured bacterium CSLC2
Function: Not known
Sequence: MTPRKVARILVAPNERDAARRIVRTTYEAQGYAIDESFATFLEGPSATTFGLFNGEVLYGTISIINDGAQGLPMDSIYAVELAAWRGEGKKLAEVVQFAMDHTLYEAVAGAKPSPFEAASLFTMVLTYALETHIDYLCISINPKHDTFYSLLGFTQIGALKHYGTVNAPAIARALYVPEWRSQTLLAQFMDAERSH
InterPro domains: - IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [7-175]
- IPR054597: N-acyl amino acid synthase FeeM, catalytic core (domain) [18-172]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0016999 (antibiotic metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0017000 (antibiotic biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0022607 (cellular component assembly), GO:0043933 (protein-containing complex organization), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Monofunctional chorismate mutase (EC 5.4.99.5) (Q9HU05)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate.
Subcellular location: Periplasm {ECO:0000269|PubMed:11532214}.
Sequence: MRPSFASWGLLALLLLQGPLLQAQPLSPALQQLLSLSSQRLQLADQVAQSKAQSGKAVQDSPREEQQLQMLAGQAGSHGVGAEQVRLLFAAQIEANKLVQYRLLSRPLPDAGQAVDLERIRSRLNQLNLELLRGYAPALAELRVDDCRPRLNQALQRQVRVDRLDELHAIALSRAAGDLCHWAEL
InterPro domains: - IPR008240: Chorismate mutase, periplasmic (family) [1-183]
- IPR036979: Chorismate mutase domain superfamily (homologous_superfamily) [21-184]
- IPR051331: Chorismate mutase-related enzymes (family) [1-116]
- IPR036263: Chorismate mutase type II superfamily (homologous_superfamily) [30-183]
- IPR002701: Chorismate mutase II, prokaryotic-type (domain) [7-104]
Interaction partners: - Cyclohexadienyl dehydratase
- Chorismate synthase
- Bifunctional chorismate mutase/prephenate dehydratase
- Aromatic-amino-acid aminotransferase
- Aspartate aminotransferase
- Anthranilate synthase component 2
- Anthranilate synthase component 1, pyocyanine specific
- Anthranilate synthase component 1
- Anthranilate synthase component 2, pyocyanine specific
- Salicylate biosynthesis isochorismate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016866 (intramolecular transferase activity), GO:0004106 (chorismate mutase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0046417 (chorismate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042597 (periplasmic space)
Protein: Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (F1LRA7)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MESSRSLLGCLASAAAAPPGEDATGAGAEEEEDEEEAAAELGSHATLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGTEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWVGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRVPPDILVNWAVQIARGMNYLHDEAIVPVIHRDLKSSNILILQKVENGDLSNKTLKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFSSILDQLTTIEESGFFEMPKDSFHCLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLISNRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELTSGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLGKGPRSSPALPGFTSLMEIEDEDSEGPGSGENHLQHSPNQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRSGTHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPPEEPEPPAREEKKRREGLFQRASRPRRSTSPPSRKLFKKEEPMTLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLTQCTQNPLVNVRVERFKRDPNQSLTPTHVTLTAPTQPSGHRRTPSDGALKPASVPPALGSRSPSSNGVSPGPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSASPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPLQAGPLPPAERTLLDLDAEGQSQDSTVPLCRAELNAHGPSPYEIQQEFWS
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [108-396]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [46-127]
- IPR001452: SH3 domain (domain) [45-109]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [257-269]
- IPR035779: MLK1-3, SH3 domain (domain) [49-106]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [213-389]
- IPR017441: Protein kinase, ATP binding site (binding_site) [143-164]
- IPR000719: Protein kinase domain (domain) [137-405]
- IPR016231: Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4 (family) [11-1100]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [82-406]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Transcriptional regulator MIT1 (P40002)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transcriptional regulator of pseudohyphal growth.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Sequence: MDIEPTFKGYIEDEDDALLILQATLDGKLKHIPRRPYEIERPYLIVSGSIFVFIEEISGIKRWTDGVSWSPSRISGKFLIYKELDKENAGSNANATSSGSTDSAVITDGTSGARNNPSSSKIKLPPLKNHQFDLPPTMGHSSFESEQDTSISPSNRSNLPLKYTGLVKKTISVKLKRPPFNSIENLHIVSYYSVKDIKQNCLVTPKASPFLKDVRPSQELIVAMGNTTLGNVKNNSTTTGNGPNNINNKSNSSTPLNTVISTNNNSANINAAGSNQFTSANKNYYYKNDESSGYPITQFAPALPSTTLMYTANPPYITQSPDNTNATGMNTHVNNNNNNSNNSSNSNNSNNNNNNNNNNNNNNNNNINNINNVNTNAGNGNNPNRFHNASFAYNTTGDFINPQQQGQISYPFYYTTIPINNPNYYTTQPPNPVTNASTNENQGYSTSSTQHPYYGHPTESQSASAAAGATGTPGTAENVLPVSSMQPLLHQANNNSASSATSTAPYPVYSMNVNVPYYNSSASAYKRAQENTTSNTNAEPSGATSTNSGTMLSNPAYANSQYTPSQVYYQGFPQYAMASAQNPSMYQHQHQHPLPTVYPIATPQQNIMSSGHTLSTIGSDPQHHHYQQEPNDHKNFAMGHANNNILNITNNDTMNNLNTNTSTTTQ
InterPro domains: - IPR018608: Gti1/Pac2 family (family) [2-661]
Interaction partners: - Peptide methionine sulfoxide reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:0051049 (regulation of transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)
Protein: Neuroguidin (D3ZBL3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cell projection, filopodium {ECO:0000256|ARBA:ARBA00004486}. Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Sequence: MAVTAQVQALTAKVRAGAYSTEKGLSLLEVKDQLLLMYLMDLSHLILDKASGGSLQGHPAVLRLVEIRTVLEKLRPLDQKLKYQIDKLVKTAVTGSLSENDPLRFKPHPSNMMSKLSSEDEEENEAEEDQSEASGKKSVKGASKKYVPPRLVPVHYDETEAEREQKRLEKAKRRALSSSVIRELKEQYSDAPEEIRDVRHPHVTRQSQEDQHRINYEESMMVRLSVSKREKGLRRRASAMSSQLHSLTHFSDISALTGGTAHLDEDQNPVKKRKKMPKKGRKVFGGAGDELMHALLVITVCRRLPWKCGKSF
InterPro domains: - IPR007146: Sas10/Utp3/C1D (family) [3-73]
Interaction partners: - Nucleolar protein 10
- KRR1 small subunit processome component
- WD repeat-containing protein 46
- U3 small nucleolar RNA-associated protein 18 homolog
- Probable U3 small nucleolar RNA-associated protein 11
- Something about silencing protein 10
- UTP6 small subunit processome component
- UTP14A small subunit processome component
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar RNA-associated protein 4 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0023051 (regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050804 (modulation of chemical synaptic transmission), GO:0034248 (regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0006417 (regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:0099170 (postsynaptic modulation of chemical synaptic transmission), GO:2000112 (regulation of cellular macromolecule biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0045202 (synapse), GO:0098978 (glutamatergic synapse)
Protein: Low conductance mechanosensitive channel YnaI (P0AEB5)
Organism: Escherichia coli (strain K12)
Function: Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22874652}; Multi-pass membrane protein {ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:22874652}.
Sequence: MIAELFTNNALNLVIIFGSCAALILMSFWFRRGNRKRKGFLFHAVQFLIYTIIISAVGSIINYVIENYKLKFITPGVIDFICTSLIAVILTIKLFLLINQFEKQQIKKGRDITSARIMSRIIKITIIVVLVLLYGEHFGMSLSGLLTFGGIGGLAVGMAGKDILSNFFSGIMLYFDRPFSIGDWIRSPDRNIEGTVAEIGWRITKITTFDNRPLYVPNSLFSSISVENPGRMTNRRITTTIGLRYEDAAKVGVIVEAVREMLKNHPAIDQRQTLLVYFNQFADSSLNIMVYCFTKTTVWAEWLAAQQDVYLKIIDIVQSHGADFAFPSQTLYMDNITPPEQGR
InterPro domains: - IPR006685: Mechanosensitive ion channel MscS (domain) [162-229]
- IPR045042: Mechanosensitive ion channel protein YnaI-like (family) [40-334]
- IPR011014: Mechanosensitive ion channel MscS, transmembrane-2 (homologous_superfamily) [79-160]
- IPR011066: Mechanosensitive ion channel MscS, C-terminal domain superfamily (homologous_superfamily) [231-335]
- IPR006686: Mechanosensitive ion channel MscS, conserved site (conserved_site) [194-228]
- IPR010920: LSM domain superfamily (homologous_superfamily) [162-228]
- IPR049142: Mechanosensitive ion channel, transmembrane helices 2/3 (domain) [121-161]
- IPR049278: Mechanosensitive ion channel MscS, C-terminal domain (domain) [237-324]
- IPR023408: Mechanosensitive ion channel MscS, beta-domain superfamily (homologous_superfamily) [179-229]
Interaction partners: - Moderate conductance mechanosensitive channel YbiO
- Large-conductance mechanosensitive channel
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0042802 (identical protein binding), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0008381 (mechanosensitive monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cation/H+ exchanger transmembrane domain-containing protein (Q387G6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MVDHISLCVLFASPLSFPLSNLFLFIFAFYSRELSSWKRRRVMAKHPGEGEGEQQRLSMGAKRSTHAQSPSQPPDATAAPIEILDASKPLPGDSSDCRPGSSETIIVFPPPSIFKRVGSTQRPLRGDTKPHASGTAVSFDEKTTSREPISHQTKVNPPPSINVHRVPTGGQPVPAGPRQVNEVPPKMDDDAADTASTPEPDDEHLRSLTVDVMSPIISEEGEAKGTVTCPVDAICEQVDNLSSDGDKADIAFVLYSQYLKDYERKPSFTADTWDEIKYVGDSGRRFGVLYDEERGAVQLILFGKCYRIFILSFLLRFICLILFWAVMYMLASRSKFSPGGLYFDTLCTILFAGVVGSIISRVTRVPSVACAVLAAALYNNIPPTGSLTAGTSLDMRGVISLFGLTVGMIRGGLALNLRALKANFFRYLCFSVVPMVAEAFAHGFLAKILFRYPTTTWALLHGFIVTANAPGIIIPALIELQRKGYGTRGGPGVMILISVSVEATFCVWTIQLLLAIQFNTMGLLLAGLLGPIQIIVGLVVGVGLGYAFYFVVFDILYKEGQRVPLRESTILYATQRHLSHVRLTSCFIVMLVSMVCTSVGRMVSCIGGAAVIIVTMLALFSHWCDVASKMEHLTAKGDVLVFFRVLWDYVAMPALFAMAGASVNFSEVFSGDFFAPGIACVLAGLVVRCLSSMITPLLLRMPFTWRELVFCGIGSLGKGPMQAAFGAVPLMFLQTMGANSGNSTGTADDFSADDDIKHAQTLKNSAVLSMLVACPLCSILLGVLAQKLLRRDAPSVPAAAK
InterPro domains: - IPR006153: Cation/H+ exchanger, transmembrane domain (domain) [354-732]
- IPR051843: Monovalent cation:proton antiporter 1 (family) [150-797]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0015385 (sodium:proton antiporter activity), GO:0051139 (metal cation:proton antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0035869 (ciliary transition zone), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)