Protein: Abcc8 protein (Q6PGE2)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: ADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRADK
InterPro domains: - IPR017871: ABC transporter-like, conserved site (conserved_site) [157-823]
- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [308-652]
- IPR003593: AAA+ ATPase domain (domain) [32-891]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [7-907]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [6-906]
- IPR050173: ATP-binding cassette transporter C-like (family) [9-905]
- IPR011527: ABC transporter type 1, transmembrane domain (domain) [342-633]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0140678 (molecular function inhibitor activity), GO:0140677 (molecular function activator activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0016247 (channel regulator activity), GO:0097367 (carbohydrate derivative binding), GO:0016248 (channel inhibitor activity), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0099106 (ion channel regulator activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0099103 (channel activator activity), GO:0015459 (potassium channel regulator activity), GO:0043531 (ADP binding), GO:0017076 (purine nucleotide binding), GO:0005246 (calcium channel regulator activity), GO:0008200 (ion channel inhibitor activity), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0005524 (ATP binding), GO:0019870 (potassium channel inhibitor activity), GO:0019855 (calcium channel inhibitor activity), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0046887 (positive regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0051224 (negative regulation of protein transport), GO:0010647 (positive regulation of cell communication), GO:0051222 (positive regulation of protein transport), GO:0010817 (regulation of hormone levels), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0046883 (regulation of hormone secretion), GO:1903532 (positive regulation of secretion by cell), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:0002792 (negative regulation of peptide secretion), GO:0050709 (negative regulation of protein secretion), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:1904950 (negative regulation of establishment of protein localization), GO:0090278 (negative regulation of peptide hormone secretion), GO:0050714 (positive regulation of protein secretion), GO:0046676 (negative regulation of insulin secretion), GO:0002791 (regulation of peptide secretion), GO:0032024 (positive regulation of insulin secretion), GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0050796 (regulation of insulin secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)