Protein: Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1) (Q969G9)
Organism: Homo sapiens (Human)
Function: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
Subcellular location: Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}.
Sequence: MGKLHSKPAAVCKRRESPEGDSFAVSAAWARKGIEEWIGRQRCPGGVSGPRQLRLAGTIGRSTRELVGDVLRDTLSEEEEDDFRLEVALPPEKTDGLGSGDEKKMERVSEPCPGSKKQLKFEELQCDVSMEEDSRQEWTFTLYDFDNNGKVTREDITSLLHTIYEVVDSSVNHSPTSSKMLRVKLTVAPDGSQSKRSVLVNQADLQSARPRAETKPTEDLRSWEKKQRAPLRFQGDSRLEQSGCYHHCVDENIERRNHYLDLAGIENYTSQFGPGSPSVAQKSELPPRTSNPTRSRSHEPEAIHIPHRKPQGVDPASFHFLDTPIAKVSELQQRLRGTQDGSKHFVRSPKAQGKSVGVGHVARGARNKPPLGPAIPAVSPSAHLAASPALLPSLAPLGHKKHKHRAKESQQGCRGLQAPLASGGPVLGREHLRELPALVVYESQAGQPVQRHEHHHHHEHHHHYHHFYQT
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [117-174]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [144-156]
- IPR002048: EF-hand domain (domain) [131-166]
- IPR040140: Protein naked cuticle-like (family) [1-469]
Interaction partners: - Segment polarity protein dishevelled homolog DVL-1
- Segment polarity protein dishevelled homolog DVL-3
- Segment polarity protein dishevelled homolog DVL-2
- Axin-2
- Protein naked cuticle homolog 2
- Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Palmitoleoyl-protein carboxylesterase NOTUM
- Serine/threonine-protein phosphatase 2A activator
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019838 (growth factor binding), GO:0051117 (ATPase binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0017022 (myosin binding), GO:0031625 (ubiquitin protein ligase binding), GO:0032036 (myosin heavy chain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1903829 (positive regulation of protein localization), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060341 (regulation of cellular localization), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0051668 (localization within membrane), GO:0009894 (regulation of catabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:1904377 (positive regulation of protein localization to cell periphery), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0010628 (positive regulation of gene expression), GO:0030111 (regulation of Wnt signaling pathway), GO:0032880 (regulation of protein localization), GO:1905477 (positive regulation of protein localization to membrane), GO:0010468 (regulation of gene expression), GO:0072657 (protein localization to membrane), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0016192 (vesicle-mediated transport), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:1905475 (regulation of protein localization to membrane), GO:0030162 (regulation of proteolysis), GO:0016050 (vesicle organization), GO:1990778 (protein localization to cell periphery), GO:0048193 (Golgi vesicle transport), GO:0045862 (positive regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:0006906 (vesicle fusion), GO:0072659 (protein localization to plasma membrane), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:1904375 (regulation of protein localization to cell periphery), GO:0048284 (organelle fusion), GO:0061025 (membrane fusion), GO:1903317 (regulation of protein maturation), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:1903078 (positive regulation of protein localization to plasma membrane), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:1903319 (positive regulation of protein maturation), GO:1903076 (regulation of protein localization to plasma membrane), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0090174 (organelle membrane fusion), GO:0010954 (positive regulation of protein processing), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0070613 (regulation of protein processing), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0016328 (lateral plasma membrane), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0016323 (basolateral plasma membrane), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)