wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: LSM family member 14B (Protein LSM14 homolog B) (F1Q898)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MSSGTPYIGSKISLISKAQIRYEGILYTIDTDNSTVALAKVRSFGTEGRPTDRPVPARDEIFEYIIFRGSDIKDITVCEPLKVHHGLPQDPAIVQSSVGTSSVHYPSQSSYSPYRGVLPAYNQLAASSLFSQQYAAALGLGLHGVSGRRGPMVEQAVQTVPAEKTQQQQQQKKSLGGGQQGGAQRGARAQRGDSSSAQQAVLKGQSPANNENKPPTSRRKPGTRRSRNRGQGQLLVGSTKPSTLQFEADFDFETANAQFNKDDLEKEIEDQNSVQEPRSPPEEHSAVEQQKQDSEHESAAEDDPLGPKCFYNKAKSFFDNISSELRSRRTTWAEERKLNVETFGVPGRYLRAGGFRGFGGRRGRGAAQRTLTHRAGSARV
InterPro domains: - IPR025761: FFD box (domain) [309-325]
- IPR047575: Sm domain (domain) [1-81]
- IPR010920: LSM domain superfamily (homologous_superfamily) [6-82]
- IPR025762: DFDF domain (domain) [238-274]
- IPR019050: FDF domain (domain) [244-347]
- IPR025768: TFG box (domain) [327-347]
- IPR025609: Lsm14-like, N-terminal (domain) [1-98]
Interaction partners: - RNA helicase
- Enhancer of mRNA-decapping protein 3
- Eukaryotic translation initiation factor 4E nuclear import factor 1
- RNA helicase
- m7GpppN-mRNA hydrolase
- ATP-dependent RNA helicase
- Importin subunit alpha
- ATP-dependent RNA helicase
- 40S ribosomal protein S27
- Polyadenylate-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Fatty acid binding protein, isoform C (Q8INK3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSFVGKKYKLDKSENFDEYMKELGVGLVTRKMGNSLSPTVEVTLEGDTYTLTTTSTFKTSAISFKLGVEFDEETLDGRNVKSIITLDGNKLTQEQKGDKPTTIVREFTDNELITLIPHLTPSQHGSLRLRVPCQPVPPTSVDDGARSGGCGQRPGGP
InterPro domains: - IPR000463: Cytosolic fatty-acid binding (domain) [4-79]
- IPR012674: Calycin (homologous_superfamily) [1-119]
- IPR031259: Intracellular lipid binding protein (family) [2-114]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [7-112]
Interaction partners: - Protein ultraspiracle
- Ecdysone-induced protein 75B, isoform B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0008289 (lipid binding), GO:0043168 (anion binding), GO:0005504 (fatty acid binding), GO:0043177 (organic acid binding), GO:0031406 (carboxylic acid binding), GO:0033293 (monocarboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0007610 (behavior), GO:0007611 (learning or memory), GO:0050877 (nervous system process), GO:0007613 (memory), GO:0050890 (cognition), GO:0007616 (long-term memory)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Q3LS18)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MDHNNREKDERPRPAKALPVRTGHSSRPSSSTTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGNTAEGLPQVFYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHIIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPVEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRTLFSELFERKGYSFDYVYDWVGRPIPTPGGSVHVDSGTSAITRESHGHRERPSQTQPLRNQTGVPDRRGAWDLQVGRQAHPAYLVPHLASDRHGGSVQVMSSTNGQLNADDQTGGHSNAPITAQAEVEVVEEAKCCCFFKRKRKNHSQRHHK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [40-328]
- IPR022247: Casein kinase 1 gamma C-terminal (domain) [331-429]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [160-172]
- IPR050235: Casein Kinase 1 Ser/Thr Protein Kinase (family) [44-368]
- IPR017441: Protein kinase, ATP binding site (binding_site) [50-73]
- IPR000719: Protein kinase domain (domain) [44-329]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: DNA 3'-5' helicase (EC 5.6.2.4) (DNA 3'-5' helicase II) (Q9L7T3)
Organism: Pseudomonas aeruginosa
Function: Not known
Sequence: MNDDLSLLLNSLNDPQRQAVAAPLGRQLVLAGAGSGKTRVLVHRIAWLIQVEHASPYSILSVTFTNKAAAEMRHRIEQLLGINPAGMWVGTFHGLAHRLLRAHWREAGLSENFQILDSDDQQRLVKRVIRELGLDEQRWPARQAQWFINGQKDEGLRPQHIQPGGDLFLATMLKIYEAYEAACARAGVIDFSELLLRALDLWRDHPGVLEHYQRRFRHILVDEFQDTNAVQYAWLRILAKGGDSLMVVGDDDQSIYGWRGARIENIQQFSDDFADAEVIRLEQNYRSTASILKAANALIANNQGRLGKELWTDGEDGESLSLYAAFNEHDEARYVVESIESALKGGLARSEIAILYRSNAQSRVLEEALLREKIPYRIYGGQRFFERAEIKNAMAYLRLLDGRGNDAALERVVNVPARGIGEKTVESIREFARGNDVSMWEAIRLMIANKVLPGRAASALTGFVELIENLSAKVMDMPLHLMTQTVIEQSGLISYHKEEKGEKGQARVENLEELVSAARAFENSEEEEDLTPLQAFLSHASLEAGETQADAHEDSVQLMTLHSAKGLEFPLVFLVGMEEGLFPHKMSLEESGRLEEERRLAYVGVTRAMQRLVLTYAETRRLYGSETYNKVSRFIREIPPALIQEVRLSNTVSRPYGGTSRSAGGNLFSGAGVPETPFSLGQRVRHALFGEGTILNFEGAGAQARVQVNFESEGSKWLMLGYAKLEAL
InterPro domains: - IPR005753: DNA helicase, ATP-dependent, UvrD type (family) [8-726]
- IPR014017: UvrD-like DNA helicase, C-terminal (domain) [279-618]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [9-644]
- IPR000212: DNA helicase, UvrD/REP type (family) [10-645]
- IPR014016: UvrD-like helicase, ATP-binding domain (domain) [10-288]
- IPR013986: DExx box DNA helicase domain superfamily (homologous_superfamily) [116-189]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0004386 (helicase activity), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0140097 (catalytic activity, acting on DNA), GO:0003678 (DNA helicase activity), GO:0043138 (3'-5' DNA helicase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006298 (mismatch repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0044815 (DNA packaging complex)
Protein: Protein STRICTOSIDINE SYNTHASE-LIKE 13 (AtSSL13) (Protein LESS ADHERENT POLLEN 3) (Strictosidine synthase 11) (AtSS11) (Q9M1B4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required for the exine formation during pollen development.
Subcellular location: Vacuole {ECO:0000250}.
Sequence: MEKKGQHGTYESMMTHHPILCIIALSVLFIAIDPFHMSPIGGREFKPVKHEVAPYKEVMGSWPRDNLSRLGNHGKLEFVDQVFGPESLEFDSLGRGPYTGLADGRVVRWMGEAIGWETFSVVTSKWSEEACVRGVDSTTNKQWKHEKLCGRPLGLRFHKETGNLYIADAYYGLLVVGPEGGIATPLATHVEGKPILFANDLDIHRNGSIFFTDTSKRYDRANHFFILLEGESTGRLLRYDPPTKTTHIVLEGLAFPNGIQLSKDQSFLLFTETTNCRLVKYWLEGPKMGEVEVVADLPGFPDNVRINEEGQFWVAIDCCRTPAQEVLTNNPWIRSIYFRLPIPMKLLAKTMGMRMYTVISRFDEEGKVLEVLEDRQGKVMKLWIGTVAHNHIATLPYPLTMNQ
InterPro domains: - IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [71-402]
- IPR018119: Strictosidine synthase, conserved region (domain) [199-285]
Interaction partners: - Probable beta-1,3-galactosyltransferase 8
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
- Probable glucan endo-1,3-beta-glucosidase A6
- Probable alkaline/neutral invertase B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Germin-like protein subfamily 2 member 4 (Q9M263)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Subcellular location: Secreted, extracellular space, apoplast {ECO:0000250}.
Sequence: MDSRCFGFFFTLLSLNVIVLAYDPDTLQDLCVADRTSGIKVNGFTCKPESNITASDFFFAGIGKPAVVNNTVGSAVTGANVEKIAGLNTLGVSLARIDYAPGGLNPPHTHPRATEVIFVLEGELDVGFITTANKLFAKTVKKGEVFVFPRGLIHYQKNNDKAKPASVISAFNSQLPGTQSIAATLFTATPAIPDHVLTTTFQIGTKEIEKIKSKFAPKKV
InterPro domains: - IPR019780: Germin, manganese binding site (binding_site) [103-116]
- IPR006045: Cupin 1 (domain) [58-209]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [22-218]
- IPR001929: Germin (family) [23-215]
- IPR011051: RmlC-like cupin domain superfamily (homologous_superfamily) [23-216]
Interaction partners: - Chitinase-like protein 2
- Coatomer subunit epsilon-2
- SKU5 similar 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0050793 (regulation of developmental process), GO:0010496 (intercellular transport), GO:0006810 (transport), GO:2000280 (regulation of root development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0055044 (symplast), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction)
Protein: Spermidine/putrescine transport system permease protein PotB (P0AFK4)
Organism: Escherichia coli (strain K12)
Function: Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Sequence: MIVTIVGWLVLFVFLPNLMIIGTSFLTRDDASFVKMVFTLDNYTRLLDPLYFEVLLHSLNMALIATLACLVLGYPFAWFLAKLPHKVRPLLLFLLIVPFWTNSLIRIYGLKIFLSTKGYLNEFLLWLGVIDTPIRIMFTPSAVIIGLVYILLPFMVMPLYSSIEKLDKPLLEAARDLGASKLQTFIRIIIPLTMPGIIAGCLLVMLPAMGLFYVSDLMGGAKNLLIGNVIKVQFLNIRDWPFGAATSITLTIVMGLMLLVYWRASRLLNKKVELE
InterPro domains: - IPR035906: MetI-like superfamily (homologous_superfamily) [1-269]
- IPR000515: ABC transporter type 1, transmembrane domain MetI-like (domain) [55-272]
Interaction partners: - Spermidine/putrescine-binding periplasmic protein
- Putrescine transport system permease protein PotI
- Spermidine/putrescine import ATP-binding protein PotA
- Spermidine/putrescine transport system permease protein PotC
- Putrescine transport ATP-binding protein PotG
- Inner membrane ABC transporter permease protein YdcV
- Putrescine-binding periplasmic protein PotF
- Uncharacterized ABC transporter ATP-binding protein YdcT
- sn-glycerol-3-phosphate import ATP-binding protein UgpC
- Maltose/maltodextrin import ATP-binding protein MalK
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015203 (polyamine transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015695 (organic cation transport), GO:0015846 (polyamine transport), GO:0015847 (putrescine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0043190 (ATP-binding cassette (ABC) transporter complex), GO:0098533 (ATPase dependent transmembrane transport complex)
Protein: Eukaryotic translation initiation factor 1A (eIF-1A) (Eukaryotic translation initiation factor 4C) (eIF-4C) (P38912)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
Sequence: MGKKNTKGGKKGRRGKNDSDGPKRELIYKEEGQEYAQITKMLGNGRVEASCFDGNKRMAHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNLDEARTLKNQGELPENAKINETDNFGFESDEDVNFEFGNADEDDEEGEDEELDIDDI
InterPro domains: - IPR018104: Translation initiation factor 1A (eIF-1A), conserved site (conserved_site) [41-63]
- IPR001253: Translation initiation factor 1A (eIF-1A) (family) [1-153]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [2-146]
- IPR006196: RNA-binding domain, S1, IF1 type (domain) [22-96]
Interaction partners: - Eukaryotic translation initiation factor 2 subunit gamma
- Eukaryotic translation initiation factor 5
- Eukaryotic translation initiation factor 3 subunit A
- Eukaryotic translation initiation factor 3 subunit C
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein uS3
- Eukaryotic translation initiation factor 5B
- Eukaryotic translation initiation factor 2 subunit beta
- Small ribosomal subunit protein uS10
- Eukaryotic translation initiation factor eIF-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006413 (translational initiation), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (P08689)
Organism: Rattus norvegicus (Rat)
Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity).
Subcellular location: Secreted. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
Sequence: MEKGEVASLRCRLLLLLLLLTLPPTHQGRTLRHIDPIQSAQDSPAKYLSNGPGQEPVTVLTIDLTKISKPSSSFEFRTWDPEGVIFYGDTNTEDDWFMLGLRDGQLEIQLHNLWARLTVGFGPRLNDGRWHPVELKMNGDSLLLWVDGKEMLCLRQVSASLADHPQLSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSTSARTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHTDPWTFSLELGFKLVDGAGRLLTLGTGTNSSWLTLHLQDQTVVLSSEAEPKLALPLAVGLPLQLKLDVFKVALSQGPKMEVLSTSLLRLASLWRLWSHPQGHLSLGALPGEDSSASFCLSDLWVQGQRLDIDKALSRSQDIWTHSCPQSPSNDTHTSH
InterPro domains: - IPR051145: Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent (family) [39-285]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [24-395]
- IPR001791: Laminin G domain (domain) [46-218]
Interaction partners: - Muellerian-inhibiting factor
- Corticosteroid-binding globulin
- Albumin
- Insulin-2
- Insulin-1
- Aromatase
- Insulin-like growth factor 1
- Estrogen receptor
- Androgen receptor
- Prolactin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0042562 (hormone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)