Protein: DNA polymerase (EC 2.7.7.7) (Q585S7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU000442}.
Sequence: MTDSPDLSRPPVPPDYLQSDLLFQLLDCCQTQGSPHGIVSTVKHEDVPIVRIYGVTKEGHSVLVHCYNFEPHLWIRAPNRWLDVYSKTFVQELNASLDPLTHVSNTVVRIERHKRRSLMYYNPDGECDYLKVIVQLPQHIPRLRTLLSSGVMCVGAWEGLRAFPTFESNVIFPLRFMVDGNIGGCNWITVPAGQFHLFSPRTSTCQIEVCCSHEVLQSHEAVGDYLLIAPFRILSIDIECEGRKGLFPEAERDPVIQIANHCVNYGKEEDALTRTIFTLKSCGAIAGANVCSFETEEEMLVQWARFVKRIDPDFLTGYNICNFDFPYLLSRGITLKVNDSFFYWGRQLNERTVHREKKFLSRQLGNREYTELTMEGRVVMDVMAVIQRDYKLRAYSLNAVSQHFLGEQKEDVHHSIISDLQQGNDETRRRLAVYCLKDAYLPVKLLERLMVVVNNVEMARVTGVPIGWLLERGQQIKVFSMLLRKARARNFVVPTVETTGAEQRRYEGATVIEPKKGHYIEPIVTLDFASLYPSIIIAHNLCYSTLLPGHEVNNYESGMKEDTPTEHKFIRKEVFPGVLPEVLRDLLAARRQARALMKDVSQDSLEYKVLNGRQLALKVSANSVYGFTGAQVGRLPCLELSATVTSYGRRMIEETKQFVEKKYVGAEVIYGDTDSVMIRCVINADESDTNKLQQAMDFGKEAAEAVSSTFPDPIRLEFEKVYYPFLLMNKKRYAGLLWTNTVRYDKLDAKGIETVRRDSCPLVASVISGVLNRMLIQRSVESAVEFVKGTIRDLLHNRLDISQLVITKSFSKSESEYAGAQAHIALVERMRRRDPASAPNVGDRVAYVIVRAAKGAKAYERSEDPIYVLENNIPIDTQHYLEHQLGPPLLRVFEGVLQDPSVLTKGDHTRYVSVSAPNRNAGGLMKFVKFQLQCISCRSVIQEGALCDACSVMGPDIYGKIVAKRNHYEAVYSQVWTQCQQCQGSLNQEVICTSRDCPVFYLRKKVQKDVHEQQTLLDRFGVVDDW
InterPro domains: - IPR042087: DNA polymerase family B, thumb domain (homologous_superfamily) [751-904]
- IPR043502: DNA/RNA polymerase superfamily (homologous_superfamily) [489-901]
- IPR023211: DNA polymerase, palm domain superfamily (homologous_superfamily) [505-734]
- IPR017964: DNA-directed DNA polymerase, family B, conserved site (conserved_site) [670-678]
- IPR006133: DNA-directed DNA polymerase, family B, exonuclease domain (domain) [165-400]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [43-468]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [230-450]
- IPR050240: DNA polymerase type-B (family) [18-939]
- IPR006172: DNA-directed DNA polymerase, family B (family) [229-682]
- IPR025687: C4-type zinc-finger of DNA polymerase delta (domain) [934-1003]
- IPR006134: DNA-directed DNA polymerase, family B, multifunctional domain (domain) [465-894]
Interaction partners: - Proliferating cell nuclear antigen
- DNA polymerase delta subunit 2, putative
- Flap endonuclease 1
- DNA polymerase alpha subunit B
- DNA primase large subunit
- DNA polymerase epsilon catalytic subunit
- DNA primase
- DNA polymerase
- DNA polymerase II subunit 2
- DNA replication licensing factor MCM5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0140097 (catalytic activity, acting on DNA), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0034061 (DNA polymerase activity), GO:0016779 (nucleotidyltransferase activity), GO:0003887 (DNA-directed DNA polymerase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process), GO:0006260 (DNA replication), GO:0006281 (DNA repair), GO:0006261 (DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0140535 (intracellular protein-containing complex), GO:0043233 (organelle lumen), GO:0031261 (DNA replication preinitiation complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0071162 (CMG complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)