Protein: Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor) (Q8UUY8)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P07550}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P07550}.
Sequence: MENVSTPAVFNLSDLSVEMNSSSRQWSYSEYSEAVAVLLGILMALLVMCIVFGNVLVITAIVRFQRLQTVTNMFITSLACADLVMGLLVVPFGACYILLNTWHFGSFLCEFWTAADVLCVTASIETLCVIALDRYLAITSPLRYPSLLTKRKACVVVVTVWGVAALISFLPIHMKWWVSDEPEALSCLEDAHCCDFNTNAAYAVASSVVSFYIPLAVMAFVYGRVFQEARKQLEKIRGSEGRFHAQMIDNNQGQDGGDGSGGGGGNGKRPKFCLKEHKALKTLGIIMGTFTLCWLPFFVLNVVVTIWKVDNIKMPFRILNWIGYANSAFNPLIYCRSPEFRYAFQEILCLRGAAFPTNGYIYRGHSLRLSPKDKPGSLSNNVGTVELGSLSSVTNINGYCNNPPLASIV
InterPro domains: - IPR002233: Adrenoceptor family (family) [91-348]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [53-334]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [38-348]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0043169 (cation binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0046872 (metal ion binding), GO:0031420 (alkali metal ion binding), GO:0008227 (G protein-coupled amine receptor activity), GO:0004935 (adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0051051 (negative regulation of transport), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901698 (response to nitrogen compound), GO:0007186 (G protein-coupled receptor signaling pathway), GO:1901700 (response to oxygen-containing compound), GO:0051953 (negative regulation of amine transport), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0051952 (regulation of amine transport), GO:0033604 (negative regulation of catecholamine secretion), GO:0010243 (response to organonitrogen compound), GO:0050433 (regulation of catecholamine secretion), GO:0051046 (regulation of secretion), GO:0071875 (adrenergic receptor signaling pathway), GO:0032811 (negative regulation of epinephrine secretion), GO:0014060 (regulation of epinephrine secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)