Protein: Large ribosomal subunit protein uL5 (60S ribosomal protein L11) (Vegetative-specific protein V18) (P16168)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P0C0W9}. Cytoplasm {ECO:0000250|UniProtKB:P0C0W9}.
Sequence: MSAKAATKNATKVAVKAPEATTPVETKKSKKDNVMRGLRIEKLVLNICVGESGDRLVRAAKVLEQLTGQTPVYSKARYTVRSFNIRRNEQIAAHVTVRGEKAAEILEKGLKVREFELRARNFSTQGSFGFGIQEHIDLGIKYDPSIGIYGMDFFVVLSRPGFRVAHKKRAGAKVGFQHKIGKEDAVNWFKTTYDGIVIGGKK
InterPro domains: - IPR002132: Large ribosomal subunit protein uL5 (family) [8-196]
- IPR031309: Large ribosomal subunit protein uL5, C-terminal (domain) [90-169]
- IPR057266: Large ribosomal subunit protein uL5, eukaryotic/archaeal-type (family) [26-194]
- IPR020929: Large ribosomal subunit protein uL5, conserved site (conserved_site) [63-79]
- IPR022803: Large ribosomal subunit protein uL5 domain superfamily (homologous_superfamily) [24-201]
- IPR031310: Large ribosomal subunit protein uL5, N-terminal (domain) [33-86]
Interaction partners: - Small ribosomal subunit protein eS30
- Small ribosomal subunit protein uS9
- Large ribosomal subunit protein uL16
- Small ribosomal subunit protein eS17
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL23
- 30S ribosomal protein S9
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein uS17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)