wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cytosolic iron-sulfur assembly component 3 (Cytosolic Fe-S cluster assembly factor NARFL) (Iron-only hydrogenase-like protein 1) (IOP1) (Nuclear prelamin A recognition factor-like protein) (Q7TMW6)
Organism: Mus musculus (Mouse)
Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity).
Sequence: MASPFSGALQLTDLDDFIGPSQNCIKPVKVAKKPGSGIAKIHIEDDGSYFQVNQDGRTQKLEKAKVSLNDCLACSGCVTSAETVLITQQSHEELRKVLDANKEAAPGQQRLVVVSISPQSRASLAARFRLDPTDTARKLTSFFKKIGVHFVFDTAFARNFSLLESQKEFVQRFREQANSREALPVLASACPGWICYAEKTHGNFILPYISTARSPQQVMGSLVKDFFAQQQLLTPDKIYHVTVMPCYDKKLEASRPDFFNQEYQTRDVDCVLTTGEVFRLLEEEGVSLTELEPAPLDGLTSSVSAEEPSSHRGGGSGGYLEHVFRHAAQELFGIHVAEVTYQPLRNKDFQEVTLEREGQVLLRFAVAYGFRNIQNLVQKLKRGRCPYHYVEVMACPSGCLNGGGQLKAPDTEGSELLQQLERLYSMVRTEAPEDAPGVQELYQHWLQGEDSERASRLLHTQYHAVEKPSSGLSIRW
InterPro domains: - IPR003149: Iron hydrogenase, small subunit (domain) [410-466]
- IPR004108: Iron hydrogenase, large subunit, C-terminal (domain) [112-403]
- IPR009016: Iron hydrogenase (homologous_superfamily) [70-463]
- IPR050340: Cytosolic Fe-S Cluster Assembly Factor (family) [12-476]
Interaction partners: - MMS19 nucleotide excision repair protein homolog
- Probable cytosolic iron-sulfur protein assembly protein CIAO1
- Cytosolic iron-sulfur assembly component 2B
- Cytosolic iron-sulfur assembly component 2A
- Cytosolic Fe-S cluster assembly factor NUBP1
- Cysteine desulfurase
- Ferredoxin-2, mitochondrial
- Iron-sulfur cluster assembly enzyme ISCU
- LYR motif-containing protein 4
- Anamorsin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0042221 (response to chemical), GO:0050801 (monoatomic ion homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0055080 (monoatomic cation homeostasis), GO:0055072 (iron ion homeostasis), GO:0046688 (response to copper ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0140535 (intracellular protein-containing complex)
Protein: Cysteine protease (Q54F16)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
Sequence: MRFILFFVLMLTALAAGRRLSVEESQFIAFQNKYNKIYSAEEYLVKFETFKSNLLNIDALNKQATTIGSDTKFGVNKFADLSKEEFKKYYLSSKEARLTDDLPMLPNLSDDIISATPAAFDWRNTGGSTKFPQGTPVTAVKNQGQCGSCWSFSTTGNVEGQHYLSTGTLVGLSEQNLVDCDHTCMTYENENVCNAGCDGGLQPNAYNYIIKNGGIQTEATYPYTAVDGECKFNSAQVGAKISSFTMVPQNETQIASYLFNNGPLAIAADAEEWQFYMGGVFDFPCGQTLDHGILIVGYGAQDTIVGKNTPYWIIKNSWGADWGEAGYLKVERNTDKCGVANFVSSSIVGSSN
InterPro domains: - IPR013128: Peptidase C1A (family) [26-340]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [311-330]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [143-154]
- IPR039417: Papain-like cysteine endopeptidase (domain) [117-344]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [116-347]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [25-346]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [289-299]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [27-86]
Interaction partners: - Cathepsin D
- Battenin
- Cysteine proteinase 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0006972 (hyperosmotic response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)
Protein: Transmembrane protein (Q0PBN7)
Organism: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Function: Not known
Sequence: MPADLNDYFNKKNGNSNNNGNNNRQNFNFKAPEFNFKGFGKFSPFVYGVIIIILFLIVAKPFMVINSGEMGIKSTTGKYDPNPLEPGLHFFLPFVQKITIIDTRVRQINYASIEGSNENLSSGSGVINKNSISVLDSRGLPVSIDVTVQYRLNPLQVPQTIATWSLNWENKIIDPVVRDVVRSVVGKYTAEELPTNRNTIATQIEEGIRKTIEAQPNEPVELRAVQLREIILPSKVKEQIERVQIAKQEAERTKYEVERANQEALKKAALAEGEANATIISAKGKAMAVKIEADAQAYSNKEIANSLNTPLLNLKQIETQKEFNEALKVNQDAKIFLTPGGAVPNIWVDTKDAKKQSAANMN
InterPro domains: - IPR001107: Band 7 domain (domain) [60-264]
- IPR000163: Prohibitin (family) [49-338]
- IPR036013: Band 7/SPFH domain superfamily (homologous_superfamily) [89-251]
Interaction partners: - ATP-dependent zinc metalloprotease FtsH
- Membrane bound ATPase
- Integral membrane protein
- Zinc protease-like protein
- Zinc protease
- AAA family ATPase
- Branched-chain-amino-acid aminotransferase
- Integral membrane protein
- Integral membrane protein
- Chaperone protein DnaK
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031341 (regulation of cell killing), GO:0010942 (positive regulation of cell death), GO:0051709 (regulation of killing of cells of another organism), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0010941 (regulation of cell death), GO:0044003 (modulation by symbiont of host process), GO:0031343 (positive regulation of cell killing), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0052150 (modulation by symbiont of host apoptotic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0009986 (cell surface), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0009897 (external side of plasma membrane), GO:0098797 (plasma membrane protein complex), GO:0005886 (plasma membrane)
Protein: Conserved protein (P71734)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MWRTRVVHTTGYVYQSPVTASYNEARLTPRSSSRQNLVLNRVETIPATRSYRYIDYWGTAVTAFDLHAPHTELTVTSSSVVETERPEPLAAKATWADLQSTAVIDRFDEVLRPTPHTPASARVDAVGRRIRKCHEPSEAVVAAARWARSELDYIPGTTSVHSSGLDALEQGKGVCQDFVHLSLMVLRSMGIPCRYVSGYLHPKRDAVVGKTVDGRSHAWVQAWTGGWWHYDPTNDNEITEQYISVGVGRDYTDVSPLKGIYSGEGVTDLDVVVEITRLA
InterPro domains: - IPR013589: Bacterial transglutaminase-like, N-terminal (domain) [5-82]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [8-268]
- IPR002931: Transglutaminase-like (domain) [126-234]
Interaction partners: - Conserved protein
- Uncharacterized protein Rv2411c
- Uncharacterized protein Rv2567
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0071554 (cell wall organization or biogenesis), GO:0009056 (catabolic process), GO:0006952 (defense response), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0016043 (cellular component organization), GO:0043207 (response to external biotic stimulus), GO:0044085 (cellular component biogenesis), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0071555 (cell wall organization), GO:0006790 (sulfur compound metabolic process), GO:0098542 (defense response to other organism), GO:0044248 (cellular catabolic process), GO:0098542 (defense response to other organism), GO:0042546 (cell wall biogenesis), GO:0044273 (sulfur compound catabolic process), GO:0044406 (adhesion of symbiont to host), GO:0045229 (external encapsulating structure organization), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels), GO:0052572 (response to host immune response), GO:0052553 (modulation by symbiont of host immune response), GO:0042783 (evasion of host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: fructose-bisphosphatase (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (O97193)
Organism: Leishmania major
Function: Not known
Sequence: MDVRRTPTPTTLTQYIIKSQPPHSRGDFTLLMMAIQTSVKVIEKNIRRAGMKGMLGYIAGQSANATGDHQAKLDVISNIAFKAYLLSSTSVCVLGSEEEEQMIIAESGRRGDYLIFFDPLDGSSNIDANVSVGSIWGVWRLPKDTTINSVEDANAVIRMLKGTDMVSAGYAVYGSATNLVLTSGHGVDGFTLDPNIGEFILTHPHISIPKKRSIYSVNEGNYGKWEPWFKEYIDYLKMNKTTRYSARYIGSMVGDIHRTLLYGGIFCYPKDANQVEGKLRLLYEAAPMAMIVEQAGGKAVGSNGRILEQSITRLHQRTPVYFGSRQEVDLCMAFRDRNVKTEALAPTSSKL
InterPro domains: - IPR033391: Fructose-1-6-bisphosphatase class I, N-terminal (domain) [11-204]
- IPR028343: Fructose-1,6-bisphosphatase (family) [6-340]
- IPR000146: Fructose-1,6-bisphosphatase class 1 (family) [6-341]
- IPR020548: Fructose-1,6-bisphosphatase, active site (active_site) [277-289]
- IPR044015: Fructose-1-6-bisphosphatase class 1, C-terminal (domain) [208-333]
Interaction partners: - Transketolase
- Fructose-bisphosphate aldolase
- Transaldolase
- ATP-dependent 6-phosphofructokinase
- Glucose-6-phosphate isomerase
- Phosphotransferase
- Phosphotransferase
- mannose-6-phosphate isomerase
- Pyruvate kinase
- Pyruvate kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0050308 (sugar-phosphatase activity), GO:0042132 (fructose 1,6-bisphosphate 1-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0019318 (hexose metabolic process), GO:0046364 (monosaccharide biosynthetic process), GO:0016051 (carbohydrate biosynthetic process), GO:0006006 (glucose metabolic process), GO:0019319 (hexose biosynthetic process), GO:0006094 (gluconeogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Archaemetzincin (EC 3.4.-.-) (Q8TXW1)
Organism: Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)
Function: Probable zinc metalloprotease whose natural substrate is unknown. Does not show endo- or exopeptidase activity against resorufin labeled casein, p-nitroanilide (pNA), amidomethylcoumarin (AMC) (one to three amino acids in length), and hippuryl-aminoacid substrates.
Sequence: MKLCLVAFDGRIPMLSSIVDRFEEHVSEYLGEVKVKKKRAKLPEHAYSKVRGQYLARALLDTLRGMKGEYDRVLGLTSEDLYAPGLNFVFGQARCPGREAVVSVARLLDPDPELYLERVVKELTHELGHTFGLGHCPDRNCVMSFSSSLLEVDRKSPNFCRRCTELLQRNLKRGG
InterPro domains: - IPR012091: Peptidase M54, archaemetzincin, archaeal/bacterial (family) [1-175]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [1-175]
- IPR012962: Peptidase M54, archaemetzincin (family) [1-172]
Interaction partners: - Acetyltransferase
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0002682 (regulation of immune system process), GO:0002683 (negative regulation of immune system process), GO:0048585 (negative regulation of response to stimulus), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0032101 (regulation of response to external stimulus), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0050922 (negative regulation of chemotaxis), GO:0050920 (regulation of chemotaxis), GO:0002686 (negative regulation of leukocyte migration), GO:0032102 (negative regulation of response to external stimulus), GO:0002688 (regulation of leukocyte chemotaxis), GO:0030334 (regulation of cell migration), GO:1902622 (regulation of neutrophil migration), GO:0030336 (negative regulation of cell migration), GO:0090022 (regulation of neutrophil chemotaxis), GO:0071622 (regulation of granulocyte chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein CADMIUM TOLERANCE 3 (Cd tolerant 3) (OsCDT3) (A2WLC1)
Organism: Oryza sativa subsp. indica (Rice)
Function: Confers resistance to heavy metal ions (e.g. aluminium) by chelating them at the plasma membrane of root cells, thus stopping their entry and reducing their accumulation (By similarity). Binds to and confers tolerance to aluminium (Al) (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q5VRD7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q5VRD7}.
Sequence: MYNPPAAQEMSYSDHVKKRHEDKGCLYACLFTLCCCFCCYETCECCLECLCCC
InterPro domains: - IPR051671: CYSTM1 Heavy Metal Tolerance (family) [1-53]
- IPR028144: Cysteine-rich transmembrane domain (domain) [8-43]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140313 (molecular sequestering activity), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0048229 (gametophyte development), GO:0048235 (pollen sperm cell differentiation), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: NAD(P)-binding Rossmann-fold superfamily protein (Q949S7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MLRSLIWKRSQAYSSVVTMSSISQRGNERLLSEVAGSHSRDNKILVLGGNGYVGSHICKEALRQGFSVSSLSRSGRSSLHDSWVDDVTWHQGDLLSPDSLKPALEGITSVISCVGGFGSNSQMVRINGTANINAVKAAAEQGVKRFVYISAADFGVINNLIRGYFEGKRATEAEILDKFGNRGSVLRPGFIHGTRQVGSIKLPLSLIGAPLEMVLKLLPKEVTKIPVIGPLLIPPVNVKSVAATAVKAAVDPEFASGVIDVYRILQHGH
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [42-262]
- IPR016040: NAD(P)-binding domain (domain) [48-191]
- IPR051207: Mitochondrial Complex I NDUFA9 Subunit (family) [19-257]
Interaction partners: - Ubiquinone biosynthesis protein
- Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
- 4-hydroxybenzoate polyprenyltransferase, mitochondrial
- Polyketide cyclase / dehydrase and lipid transport protein
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Probable NADH dehydrogenase 1 alpha subcomplex subunit 12
- NADH dehydrogenase 1 beta subcomplex subunit 9
- Protein ABC transporter 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0006979 (response to oxidative stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: PE family protein (Q7DA36)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function: Not known
Sequence: MTLRVVPEGLAAASAAVEALTARLAAAHASAAPVITAVVPPAADPVSLQTAAGFSAQGVEHAVVTAEGVEELGRAGVGVGESGASYLAGDAAAAATYGVVGG
InterPro domains: - IPR038332: PPE superfamily (homologous_superfamily) [7-73]
- IPR000084: PE-PGRS family, N-terminal (domain) [3-93]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Thromboxane A2 receptor (Prostanoid TP receptor) (K7ER80)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGLHRPDSAAKPACHEPRRAAVPHHGEGAAHLLARGHLEPDPGPLGVYPVPPRRAPASPASPQHPAQVAVPPAPAHAALRAAVGSGQSAPPAPFRGALGPSDSPSACSEDSGAGGAGWTVGISSRVLG
InterPro domains: - IPR008365: Prostanoid receptor (family) [23-137]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [41-137]
- IPR001105: Thromboxane receptor (family) [12-123]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [42-140]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0040013 (negative regulation of locomotion), GO:0051716 (cellular response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0010632 (regulation of epithelial cell migration), GO:2000145 (regulation of cell motility), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0010633 (negative regulation of epithelial cell migration), GO:2000146 (negative regulation of cell motility), GO:0010594 (regulation of endothelial cell migration), GO:0030334 (regulation of cell migration), GO:0010596 (negative regulation of endothelial cell migration), GO:0030336 (negative regulation of cell migration), GO:0043535 (regulation of blood vessel endothelial cell migration), GO:0043537 (negative regulation of blood vessel endothelial cell migration), GO:0090049 (regulation of cell migration involved in sprouting angiogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)