Protein: Cystatin-C (Cystatin-3) (P21460)
Organism: Mus musculus (Mouse)
Function: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.
Subcellular location: Secreted {ECO:0000250}.
Sequence: MASPLRSLLFLLAVLAVAWAATPKQGPRMLGAPEEADANEEGVRRALDFAVSEYNKGSNDAYHSRAIQVVRARKQLVAGVNYFLDVEMGRTTCTKSQTNLTDCPFHDQPHLMRKALCSFQIYSVPWKGTHSLTKFSCKNA
InterPro domains: - IPR046350: Cystatin superfamily (homologous_superfamily) [31-137]
- IPR000010: Cystatin domain (domain) [28-138]
- IPR018073: Proteinase inhibitor I25, cystatin, conserved site (conserved_site) [74-87]
Interaction partners: - Cathepsin B
- Cathepsin S
- Hepatitis A virus cellular receptor 1 homolog
- Neutrophil gelatinase-associated lipocalin
- Amyloid-beta precursor protein
- Beta-2-microglobulin
- C-reactive protein
- Albumin
- Cathepsin D
- Transthyretin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0016049 (cell growth), GO:0050794 (regulation of cellular process), GO:0001503 (ossification), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0001649 (osteoblast differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0098771 (inorganic ion homeostasis), GO:0070169 (positive regulation of biomineral tissue development), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0098868 (bone growth), GO:0048588 (developmental cell growth), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0036075 (replacement ossification), GO:0009888 (tissue development), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0045778 (positive regulation of ossification), GO:0030278 (regulation of ossification), GO:0070168 (negative regulation of biomineral tissue development), GO:0003416 (endochondral bone growth), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048562 (embryonic organ morphogenesis), GO:0061448 (connective tissue development), GO:0048513 (animal organ development), GO:0070167 (regulation of biomineral tissue development), GO:0010468 (regulation of gene expression), GO:0055074 (calcium ion homeostasis), GO:0022607 (cellular component assembly), GO:0070167 (regulation of biomineral tissue development), GO:0070167 (regulation of biomineral tissue development), GO:0060348 (bone development), GO:0055080 (monoatomic cation homeostasis), GO:0001501 (skeletal system development), GO:0001958 (endochondral ossification), GO:0002062 (chondrocyte differentiation), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0060349 (bone morphogenesis), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0060350 (endochondral bone morphogenesis), GO:0060350 (endochondral bone morphogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0048706 (embryonic skeletal system development), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane), GO:0001533 (cornified envelope)