Protein: Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o) (Q71DI3)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [2-136]
- IPR000164: Histone H3/CENP-A (family) [1-136]
- IPR007125: Histone H2A/H2B/H3 (domain) [7-132]
Interaction partners: - Histone H2A type 2-A
- Chromobox protein homolog 3
- Histone H2B type 2-E
- DNA
- Chromobox protein homolog 1
- Histone H2A type 2-C
- DNA
- Chromobox protein homolog 5
- Histone H4
- WD repeat-containing protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding), GO:0045296 (cadherin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0040029 (epigenetic regulation of gene expression), GO:0071824 (protein-DNA complex subunit organization), GO:0006338 (chromatin remodeling), GO:0006334 (nucleosome assembly), GO:0051276 (chromosome organization), GO:0065004 (protein-DNA complex assembly), GO:0032200 (telomere organization), GO:0034728 (nucleosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0000785 (chromatin), GO:0098687 (chromosomal region), GO:0044815 (DNA packaging complex), GO:0005615 (extracellular space), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0000786 (nucleosome), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0000781 (chromosome, telomeric region), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0000775 (chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome)