Protein: GTP-binding protein gtr1 (EC 3.6.5.-) (O74824)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (By similarity). Also required for TORC1 inactivation during nitrogen starvation (By similarity).
Subcellular location: Vacuole membrane {ECO:0000250|UniProtKB:A0A6A5PR12}; Peripheral membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MRKKVLLMGRSGSGKSSMRSIVFSNYVAKDTRRLGATIDIEHSHVRFLGNLVLNLWDCGGQEAFMENYLSAQRDHIFRNVQVLIYVFDVESREFERDLVTFRNCLEATVANSPQARVFCLIHKMDLVQEDLRDLVFEERKAILLETSKDLETTCLATSIWDETLFKAWSAIVYTLIPNTPTLESHLREFAKAAEAAEVILFERTTFLVISSYSSESNPATDAHRFEKISNIVKQFKLSCSKMQAQFTTFELRGGNFSAFIVPYTEDTYILVVIADPEIESAVTLMNIQSARRFIEASKSASDGIQLQP
InterPro domains: - IPR039397: RagA/B (family) [4-289]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-181]
- IPR006762: Gtr1/RagA G protein (family) [2-297]
Interaction partners: - GTP-binding protein gtr2
- Serine/threonine-protein kinase tor2
- Nitrogen permease regulator 2 homolog
- Target of rapamycin complex 1 subunit mip1
- Uncharacterized protein C1778.05c
- Nitrogen permease regulator 3-like protein
- Uncharacterized WD repeat-containing protein C4F8.11
- Serine/threonine-protein kinase tor1
- Uncharacterized WD repeat-containing protein C12G12.01c
- Vacuolar membrane-associated protein iml1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0019209 (kinase activator activity), GO:0019887 (protein kinase regulator activity), GO:0030295 (protein kinase activator activity), GO:0043539 (protein serine/threonine kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:1901564 (organonitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0016197 (endosomal transport), GO:0006508 (proteolysis), GO:1901565 (organonitrogen compound catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0030163 (protein catabolic process), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0032509 (endosome transport via multivesicular body sorting pathway), GO:0043328 (protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway), GO:0071985 (multivesicular body sorting pathway), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0045324 (late endosome to vacuole transport), GO:0051603 (proteolysis involved in protein catabolic process), GO:0032511 (late endosome to vacuole transport via multivesicular body sorting pathway), GO:0019941 (modification-dependent protein catabolic process), GO:0072665 (protein localization to vacuole), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0043162 (ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0035859 (Seh1-associated complex), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0070013 (intracellular organelle lumen), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole), GO:0098852 (lytic vacuole membrane), GO:0005634 (nucleus), GO:0000329 (fungal-type vacuole membrane)