Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (A0A8I6ADL5)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MAALSGGGGSSSGGGGGGGGGGGGGGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGADFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQTPTDVSRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEAFSAETTLPSGCSSAPPSDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSTEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [467-735]
- IPR046349: C1-like domain superfamily (homologous_superfamily) [243-296]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [171-243]
- IPR020454: Diacylglycerol/phorbol-ester binding (domain) [248-297]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [590-602]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [250-297]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [475-730]
- IPR017441: Protein kinase, ATP binding site (binding_site) [481-501]
- IPR003116: Raf-like Ras-binding (domain) [171-243]
- IPR000719: Protein kinase domain (domain) [475-735]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [375-735]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0044877 (protein-containing complex binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0051020 (GTPase binding), GO:0004709 (MAP kinase kinase kinase activity), GO:0031267 (small GTPase binding), GO:0019901 (protein kinase binding), GO:0031434 (mitogen-activated protein kinase kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0010647 (positive regulation of cell communication), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0046683 (response to organophosphorus), GO:0051591 (response to cAMP), GO:1901215 (negative regulation of neuron death), GO:0043412 (macromolecule modification), GO:0010243 (response to organonitrogen compound), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:1990089 (response to nerve growth factor), GO:1901214 (regulation of neuron death), GO:1902533 (positive regulation of intracellular signal transduction), GO:0006796 (phosphate-containing compound metabolic process), GO:0014070 (response to organic cyclic compound), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:1990090 (cellular response to nerve growth factor stimulus), GO:0043410 (positive regulation of MAPK cascade), GO:0043066 (negative regulation of apoptotic process), GO:0014074 (response to purine-containing compound), GO:0006468 (protein phosphorylation), GO:0043523 (regulation of neuron apoptotic process), GO:0016310 (phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)