Protein: Phenylalanine--tRNA ligase, mitochondrial (A8E4Z0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins
Subcellular location: Mitochondrion matrix
Sequence: MPLYSSSRTVVPLLKHIIRHCPARVFSVSRCLSTDGSAEQPQIQENSVQLFNHVYPRDDMTNVTAKILSKVGCQLHNRPHHPLWLIKERIKDHFYRSYVGRTGNPIFSVHDNLRPVVTVEQNFDSLLIPADHPSCKKGENYYLNRTHMLRAHTSAHQKELVRSGLDCFLLAGDVYRRDEVDSSHYPVFHQMEGVRLFSNHELFAGVENGEDLSLFERGGRRTPQKQETHTLEAVKLLEFDLKRALTRLVRHLFGEDLEIRWVDCYFPFTHPSFEMEVFFQGDWMEVLGCGVMEQELVRSAGADNKMGWAFGLGLERLAMVLFGIPDIRLFWSEDERFLKQFRLSDIYQPVTFQPLSKYPPLFNDISFWLPAEGYTENDFFDLVRSIGGDLVEKVTLVDTFTHPKMKKVSHCYRLVYRHMERTLTQEEVSIVHTAIQTAVEQELGVQGRF
InterPro domains: - IPR002319: Phenylalanyl-tRNA synthetase (domain) [107-341]
- IPR006195: Aminoacyl-tRNA synthetase, class II (domain) [84-349]
- IPR005121: Ferrodoxin-fold anticodon-binding domain (domain) [356-448]
- IPR036690: Ferrodoxin-fold anticodon-binding domain superfamily (homologous_superfamily) [351-448]
- IPR045864: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) (homologous_superfamily) [43-351]
- IPR004530: Phenylalanyl-tRNA synthetase, class IIc, mitochondrial (family) [224-445]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016875 (ligase activity, forming carbon-oxygen bonds), GO:0004812 (aminoacyl-tRNA ligase activity), GO:0140101 (catalytic activity, acting on a tRNA)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0009790 (embryo development), GO:0021536 (diencephalon development), GO:0048468 (cell development), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0030900 (forebrain development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016477 (cell migration), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0021872 (forebrain generation of neurons), GO:0007417 (central nervous system development), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0021761 (limbic system development), GO:0001764 (neuron migration), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0021879 (forebrain neuron differentiation), GO:0021954 (central nervous system neuron development), GO:0021884 (forebrain neuron development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)