Protein: Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) (E9PEW0)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPLPTGMG
InterPro domains: - IPR050164: Ubiquitin carboxyl-terminal hydrolases (family) [38-423]
- IPR018200: Ubiquitin specific protease, conserved site (conserved_site) [123-383]
- IPR001394: Peptidase C19, ubiquitin carboxyl-terminal hydrolase (domain) [122-420]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [119-424]
- IPR028889: Ubiquitin specific protease UPS, catalytic domain (domain) [122-423]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0008233 (peptidase activity), GO:0003723 (RNA binding), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0032388 (positive regulation of intracellular transport), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051222 (positive regulation of protein transport), GO:0031647 (regulation of protein stability), GO:0051128 (regulation of cellular component organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0090316 (positive regulation of intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0032386 (regulation of intracellular transport), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis), GO:0010507 (negative regulation of autophagy), GO:1904951 (positive regulation of establishment of protein localization), GO:0031330 (negative regulation of cellular catabolic process), GO:0070201 (regulation of establishment of protein localization), GO:0010506 (regulation of autophagy), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0032880 (regulation of protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0010468 (regulation of gene expression), GO:0016242 (negative regulation of macroautophagy), GO:1903146 (regulation of autophagy of mitochondrion), GO:2000232 (regulation of rRNA processing), GO:0016241 (regulation of macroautophagy), GO:0010821 (regulation of mitochondrion organization), GO:0070646 (protein modification by small protein removal), GO:1903955 (positive regulation of protein targeting to mitochondrion), GO:1903747 (regulation of establishment of protein localization to mitochondrion), GO:0070647 (protein modification by small protein conjugation or removal), GO:0033157 (regulation of intracellular protein transport), GO:1903749 (positive regulation of establishment of protein localization to mitochondrion), GO:0016570 (histone modification), GO:0016579 (protein deubiquitination), GO:0016578 (histone deubiquitination), GO:1903214 (regulation of protein targeting to mitochondrion), GO:1903533 (regulation of protein targeting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)