Protein: Microtubule-associated protein 1S (MAP-1S) [Cleaved into: MAP1S heavy chain; MAP1S light chain] (P0C5W1)
Organism: Rattus norvegicus (Rat)
Function: Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17658481}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17658481}. Note=Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules (By similarity). Detected in filopodia-like protrusions and synapses. {ECO:0000250}.
Sequence: MAAVMAAPEPAEAPSSLLLLVVGGECGCPGLLAYVLEELERGVRSWEDVDPDVCSLDEQLKAFVSRHSATFSSIVKGQRSLHHRGETLETLVLLNPSDKSLCDELRNLLMDPAPHKLLVLAGPCLEETGELLLQTGGFSAHHFLQVLGDKEVQDALASAPAAPALTVSCPTFGDWALLGPAPGLRLRLNPPARLPSSEGLRAFLEYVAESLEPPSPFELLEPPATGGFLRLARPCCYVFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFWKLVRHLDRVDAVLVTHAGADSLPGLNSLLRRKLAEREAAAGPQGQHEERLRRLLSPALGVVFLNAREAGSRLRGGEDEAVCARSLLRSLGIVPLPLQRGPQPSCPTVLFEKLGVGRLELFVLHPPPGDPAAPACALLVWQPAAPGDKVVRVLFPGRTPPARLLDGLQRLQHLPCLRRPVVTTQDLEVPSRANSQDSLASRDSTRKEPVRGTVGATSRSAVRREPALATRDQKKDTKPGPTRSTVRDVRRSGPGVVTTKPRVSQNGPRAPVPAAPPAAPAPEFPGEAENIVESERPPAPSPTLSPAQSPPPTAPGNSPERLSLSPLRPEPAPDASPSATTPTLTTPSLPAELGSPHSTEVDESLSVSFEQVLPAGDAGLSLPLRLARRSTSPHDVDLCLVSPCEFSHRKPPPPASPGSSDSSARSQERPPETPPTSVSESLPTLSDSDPVPVADSDDDAGSESAARDPLPTPRVPPPLPDAPGICMVDPEALPPRARQPLSTANSSRGRKAPARPSSASAAPRAATVAAKTKGPVGDRSRPLSARSEPADKPGRVPLTRKPSVPKTVPKMASATRNSSGPSSRPAPLAAGSPVYLDLAYLPGGGAGHLDQNFFLRVRALCYVISGQGQRQEEGLRGVLDALLAGKRQWDLDLQVTLIPTFDSAVMHRWYEETHEQHQALGIRVLGSGSLVSMQDEAFPACKVEF
InterPro domains: - IPR056617: Microtubule-associated protein 1B/S, N-terminal domain (domain) [19-209]
- IPR057480: Microtubule-associated protein 1A/B/S-like, MBL-like domain (domain) [214-455]
- IPR036866: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like (homologous_superfamily) [244-418]
- IPR026074: Microtubule associated protein 1 (family) [11-505]
Interaction partners: - Microtubule-associated protein 1 light chain 3 alpha
- Sequestosome-1
- Beclin-1
- Microtubule-associated protein 1 light chain 3 beta
- Ubiquitin-like protein ATG12
- Autophagy protein 5
- Ubiquitin-like modifier-activating enzyme ATG7
- Microtubule-associated protein 1 light chain 3 beta
- Ras association domain-containing protein 1
- Ubiquitin-like-conjugating enzyme ATG3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0042802 (identical protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0007017 (microtubule-based process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030425 (dendrite), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)