Protein: Serine/threonine-protein kinase akt-1 (EC 2.7.11.1) (Protein kinase B akt-1) (PKB akt-1) (Q17941)
Organism: Caenorhabditis elegans
Function: Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Plays a role in maintaining the gonadal basement membrane through it's role in inhibiting daf-16 activity. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development.
Sequence: MSMTSLSTKSRRQEDVVIEGWLHKKGEHIRNWRPRYFMIFNDGALLGFRAKPKEGQPFPEPLNDFMIKDAATMLFEKPRPNMFMVRCLQWTTVIERTFYAESAEVRQRWIHAIESISKKYKGTNANPQEELMETNQQPKIDEDSEFAGAAHAIMGQPSSGHGDNCSIDFRASMISIADTSEAAKRDKITMEDFDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLENLLLDKDGHIKIADFGLCKEEISFGDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPFYSKDHNKLFELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDALEICRADFFRTVDWEATYRKEIEPPYKPNVQSETDTSYFDNEFTSQPVQLTPPSRSGALATVDEQEEMQSNFTQFSFHNVMGSINRIHEASEDNEDYDMG
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [188-499]
- IPR001849: Pleckstrin homology domain (domain) [15-120]
- IPR039026: Protein Kinase B, pleckstrin homology domain (domain) [14-121]
- IPR000961: AGC-kinase, C-terminal (domain) [451-528]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [312-324]
- IPR017892: Protein kinase, C-terminal (domain) [471-518]
- IPR017441: Protein kinase, ATP binding site (binding_site) [199-222]
- IPR000719: Protein kinase domain (domain) [193-450]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [10-129]
Interaction partners: - Forkhead box protein O
- Phosphatidylinositol 3-kinase age-1
- 3-phosphoinositide-dependent protein kinase 1
- Phosphoinositide 3-kinase adapter subunit
- DAF-15
- Target of rapamycin homolog
- Protein skinhead-1
- Glycogen synthase kinase-3
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18
- Serine/threonine-protein kinase akt-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0043168 (anion binding), GO:0004674 (protein serine/threonine kinase activity), GO:0035091 (phosphatidylinositol binding), GO:0016301 (kinase activity), GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:1901981 (phosphatidylinositol phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0019098 (reproductive behavior), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0009791 (post-embryonic development), GO:0006793 (phosphorus metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0040028 (regulation of vulval development), GO:0035556 (intracellular signal transduction), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0019538 (protein metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:1901700 (response to oxygen-containing compound), GO:0002164 (larval development), GO:0007548 (sex differentiation), GO:0051128 (regulation of cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0043412 (macromolecule modification), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0006796 (phosphate-containing compound metabolic process), GO:0007264 (small GTPase mediated signal transduction), GO:0002119 (nematode larval development), GO:1901701 (cellular response to oxygen-containing compound), GO:1901653 (cellular response to peptide), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0040024 (dauer larval development), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation), GO:0008286 (insulin receptor signaling pathway), GO:0032869 (cellular response to insulin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:1990234 (transferase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex)