Protein: Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8) (Q8VHW2)
Organism: Mus musculus (Mouse)
Function: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Subcellular location: Cell membrane {ECO:0000305|PubMed:21127204, ECO:0000305|PubMed:21172611}; Multi-pass membrane protein {ECO:0000250}. Postsynaptic density membrane {ECO:0000269|PubMed:21172611}.
Sequence: MESLKRWNEERGLWCEKGVQVLLTTIGAFSAFGLMTIAISTDYWLYTRALICNTTNLTAGDDGPPHRGGSGSSEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRGSSEASPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLASAGGGGSGAGVGAYGGAAGAAGGGGAGSERDRGSSAGFLTLHNAFPKEAASGVTVTVTGPPAAPAPAPAPPAPAAPAPGTLSKEAAASNTNTLNRKTTPV
InterPro domains: - IPR051072: Voltage-dependent calcium channel gamma subunit (family) [13-423]
- IPR008368: Voltage-dependent calcium channel, gamma subunit (family) [28-220]
- IPR008372: Voltage-dependent calcium channel, gamma-8 subunit (family) [1-245]
- IPR004031: PMP-22/EMP/MP20/Claudin (family) [18-221]
Interaction partners: - Glutamate receptor 2
- Glutamate receptor 1
- Protein cornichon homolog 2
- Voltage-dependent L-type calcium channel subunit beta-1
- Protein shisa-9
- Voltage-dependent calcium channel subunit alpha-2/delta-2
- Disks large homolog 4
- Voltage-dependent L-type calcium channel subunit beta-4
- Cation channel sperm-associated auxiliary subunit epsilon
- Voltage-dependent N-type calcium channel subunit alpha-1B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0019902 (phosphatase binding), GO:0035254 (glutamate receptor binding), GO:0019903 (protein phosphatase binding), GO:0035255 (ionotropic glutamate receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0034762 (regulation of transmembrane transport), GO:0051049 (regulation of transport), GO:0009966 (regulation of signal transduction), GO:0010469 (regulation of signaling receptor activity), GO:0010646 (regulation of cell communication), GO:0032409 (regulation of transporter activity), GO:0022898 (regulation of transmembrane transporter activity), GO:0099601 (regulation of neurotransmitter receptor activity), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:2000311 (regulation of AMPA receptor activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0060076 (excitatory synapse), GO:0099634 (postsynaptic specialization membrane), GO:0098685 (Schaffer collateral - CA1 synapse), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane)