Protein: Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) (Q9HCL2)
Organism: Homo sapiens (Human)
Function: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:36522428}; Peripheral membrane protein {ECO:0000269|PubMed:36522428}. Note=Associated with the mitochondrion outer membrane of hepatic cells via a patch of basic residues. {ECO:0000269|PubMed:36522428}.
Sequence: MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKRPFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDVHKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVATVSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHIVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGISYDRIIEGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSALLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLLGNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLGGPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAEHDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITFLQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYCLVKNAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL
InterPro domains: - IPR022284: Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase (family) [1-819]
- IPR041728: GPAT/DHAPAT, acyltransferase domain (domain) [201-411]
- IPR028354: Glycerol-3-phosphate acyltransferase, PlsB (family) [1-822]
- IPR002123: Phospholipid/glycerol acyltransferase (domain) [220-357]
- IPR045520: GPAT/DHAPAT, C-terminal domain (domain) [364-794]
Interaction partners: - Glycerol-3-phosphate acyltransferase 3
- Glycerol-3-phosphate acyltransferase 4
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase 1-like protein
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
- Glycerol kinase
- Glycerol kinase 2
- 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
- Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0045017 (glycerolipid biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0008654 (phospholipid biosynthetic process), GO:0006654 (phosphatidic acid biosynthetic process), GO:0046473 (phosphatidic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)