Protein: Metabotropic glutamate receptor-like protein H (Q54SH8)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence: MKNILKILILILICINKINCLDGDGKQFRMIMLLSANVNDMGFNNMMNQGRIGVSKNLQIEDSRLIVVDGENDTKALVEPILQNEDIDFVICSSQGHTVACKYFADKYLKHPTVKTQFLIRGSGSSTANLIQFNYNFASCNYMSGYFAGLHTKTNKIGFLSPGAPKVNDAWVYAFWLGAKQVNPKIQFFYYNVGAFLNPDASERATNDLLERGCDVIGNTLDDFSSGITIMSKGYRTIGTNGFPQKLIYGEKILYSYAYNWTKLFLPIAMSVKAGITNNTNGYGDFNLDESKNFFNIEYSYGVSTDTINRMNQQITFLKSNSRFTHPYYCNEYLPEYTKKNNLNLSTSPTVNNLICIDHSTFLKINPPFPGMTYLGIYNISLVEVEFSQSIQNGFSITTGILIGITILMMIGIIKYSKTPSMRSASPIFLNFILAGGIIVYIGIIVWVGPMSTHSCNARLWLVTLGFSTLIGSLVVKNFRIWLIFDNPELKSIKITNYQLFPWVGACLVINIILMAILTSVGDLKQIDAMNIDSLGKYEYMKVCKMNSSGASTLYTILAYFAALLLVGVFVSWKIRIVDILEFNESGAIANTLYAISFCLFVIVPLMISPQDMQSETIILCTTGLFITTAALLIIFIPKFWRVFRKGANDSEINFNKKKSSSVATARAESGSKGSNGNASSGNRTNRRGNVVSGDFTDDSESSVGDENQKEKEKIKDDVANVTSGAVLAEFTDEASDTDNNEFNDIELSEQPPSIIVNDSENNN
InterPro domains: - IPR051530: Metabotropic Glutamate/GABA-B Receptor-like (family) [1-750]
- IPR003760: ABC transporter substrate-binding protein PnrA-like (domain) [31-220]
- IPR017978: GPCR family 3, C-terminal (domain) [387-659]
Interaction partners: - Autocrine proliferation repressor protein A
- Frizzled and smoothened-like protein B
- Frizzled and smoothened-like protein K
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0051707 (response to other organism), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0043207 (response to external biotic stimulus), GO:0010469 (regulation of signaling receptor activity), GO:0010646 (regulation of cell communication), GO:0050920 (regulation of chemotaxis), GO:0009617 (response to bacterium), GO:0009966 (regulation of signal transduction), GO:0032101 (regulation of response to external stimulus), GO:0010647 (positive regulation of cell communication), GO:0051098 (regulation of binding), GO:0051099 (positive regulation of binding), GO:1903669 (positive regulation of chemorepellent activity), GO:0050923 (regulation of negative chemotaxis), GO:0051336 (regulation of hydrolase activity), GO:1903667 (regulation of chemorepellent activity), GO:0043085 (positive regulation of catalytic activity), GO:0043393 (regulation of protein binding), GO:2000273 (positive regulation of signaling receptor activity), GO:0043087 (regulation of GTPase activity), GO:0032092 (positive regulation of protein binding), GO:0051345 (positive regulation of hydrolase activity), GO:1900120 (regulation of receptor binding), GO:1900122 (positive regulation of receptor binding), GO:0043547 (positive regulation of GTPase activity), GO:0090630 (activation of GTPase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)