wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Kallikrein 4 (Kallikrein b1) (Kallikrein-related peptidase 4) (Q6IE12)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MMVTARTPWGWFLGYLILEVTGSSASSISSRIIQGQDCLPHSQPWQAALFSEDNAFFCSGVLVHPQWVLSAAHCIQDSYTVGLGLHNLEGSQEPGSRMLEAHLSIQHPNYNDPSFANDLMLIKLNESVMESNTIRRIPVASQCPTPGDTCLVSGWGRLKNGKLPSLLQCVNLSVASEETCRLLYDPVYHLSMFCAGGGPDRKDTCNGDSGGPIVCNRSLQGLVSMGQGECGQPGIPSVYTNLCKFTNWIWTTIQTR
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [59-214]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [44-249]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [69-74]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [203-214]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [18-254]
- IPR001254: Serine proteases, trypsin domain (domain) [31-254]
Interaction partners: - Enamelin
- Ameloblastin
- Amelogenin, X isoform
- Amelotin
- Matrix metallopeptidase 20
- Odontogenic ameloblast-associated protein
- Family with sequence similarity 83, member H
- WD repeat domain 72
- Solute carrier family 24 member 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0009653 (anatomical structure morphogenesis), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0009887 (animal organ morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0097186 (amelogenesis), GO:1901575 (organic substance catabolic process), GO:0043170 (macromolecule metabolic process), GO:0048513 (animal organ development), GO:0009057 (macromolecule catabolic process), GO:0045229 (external encapsulating structure organization), GO:1901565 (organonitrogen compound catabolic process), GO:0043062 (extracellular structure organization), GO:0022411 (cellular component disassembly), GO:0030163 (protein catabolic process), GO:0042476 (odontogenesis), GO:0022617 (extracellular matrix disassembly), GO:0030198 (extracellular matrix organization), GO:0042475 (odontogenesis of dentin-containing tooth)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Fatty acid 2-hydroxylase (EC 1.-.-.-) (Q9XVS0)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}.
Sequence: MGIGADEKKPLLVQLDGQYYDIADFAPKHPGGAKVLNRLAGEEIGEFIRGEKRIMGVRHEHSEAAYNMLERYNVNAIQKGDPLIESKSGMLFKVGSLGSEYWHWIHQPYDGTLRLFDSDVLESMTRTAWWVVPAVWMPIVITFSILSVLSFSTSTDVYNSILLWSAWFVIGVLTWTLTEYSLHRWVFHWKPSPDSPNQILLHFLAHGLHHKTPMDGDRLVFPPVPATLIVGIFYLIYSNTFQWPVFCAFGAGKLFGYVTYDMVHYYLHHGSPRPRSNLHFRKVYHHNHHFKNFDVGFGISTSLWDYVFHTLGMGPL
InterPro domains: - IPR006694: Fatty acid hydroxylase (domain) [168-310]
- IPR001199: Cytochrome b5-like heme/steroid binding domain (domain) [1-78]
- IPR014430: Sterol desaturase Scs7 (family) [5-315]
- IPR036400: Cytochrome b5-like heme/steroid binding domain superfamily (homologous_superfamily) [5-83]
Interaction partners: - Cholesterol 25-hydroxylase-like protein
- Fatty acid hydroxylase domain-containing protein
- Fatty acid hydroxylase domain-containing protein
- Alkylglycerol monooxygenase
- Importin N-terminal domain-containing protein
- Serine palmitoyltransferase 1
- Ceramide glucosyltransferase 3
- Ceramide glucosyltransferase 1
- Cytochrome-b5 reductase
- Putative sphingolipid delta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0006643 (membrane lipid metabolic process), GO:1903509 (liposaccharide metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0006664 (glycolipid metabolic process), GO:0030148 (sphingolipid biosynthetic process), GO:0006687 (glycosphingolipid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (A0A024QZ33)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD
InterPro domains: - IPR018612: Nuclear speckle splicing regulatory protein 1, N-terminal (domain) [5-123]
- IPR046850: Nuclear speckle splicing regulatory protein 1, RS-like domain (domain) [239-416]
- IPR042816: Nuclear speckle splicing regulatory protein 1 (family) [1-504]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Proton-activated chloride channel (PAC) (fPAC) (Transmembrane protein 206) (Q7SY31)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Displays channel activity with distinct kinetic properties compared to the human ortholog channel.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q9H813}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
Sequence: MPIGFNKACLKNVFTVILVLIYLALTAVAVFLAYQTISDFMDKLNHPVMSVSYKEVEEFAAPGIVLFPGKAHLLSCMHHYHDNIPPLVALENLAKRECMKEEVIYHGPYSNQTEKRALVFRGPTDVRNRELIFLQLSRNETEEDFSAISYMIFAKFSDMLESSDKAAFMMDCERNYSMWTFSGGFRTWVKMSLVRTSGRRNESVEFRQESSVVKYIDKRPPLEQTNELFFIVFQWRDPFIQQVKDIVTANPWNTIAILCGVFMALFKAADFAKLSIKWMIRIRKRHIRAKMREMNQIS
InterPro domains: - IPR029366: TMEM206 protein (family) [2-298]
Interaction partners: - MANSC domain-containing 1.
- Plexin b2a.
- Reticulophagy regulator 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005253 (monoatomic anion channel activity), GO:0022836 (gated channel activity), GO:0005254 (chloride channel activity), GO:0061797 (pH-gated chloride channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0006820 (monoatomic anion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Transcription factor Sp2 (Q02086)
Organism: Homo sapiens (Human)
Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
Subcellular location: Nucleus.
Sequence: MSDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTHLVTKNL
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [525-612]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [505-608]
Interaction partners: - DNA-directed RNA polymerase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0035264 (multicellular organism growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0008283 (cell population proliferation), GO:0009790 (embryo development), GO:0048731 (system development), GO:0048144 (fibroblast proliferation), GO:0048513 (animal organ development), GO:0048568 (embryonic organ development), GO:0072359 (circulatory system development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Intermediate filament protein A (IF-A) (P23730)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Not known
Subcellular location: Cytoplasm.
Sequence: MSDLNDRLASYIEKVRFLEAQNRKLAADLDLLRGRWGKDTLSVRAMYEGELQEARKLVNDTNRQREELEKEIRKLLDELSEYRRKYEDALRGHQIDRDRIDELLNQLSGLEAEINLLRRRIANIIEEIARIKKENLQFANELTKARSDLDQETLNRIDFQNQVQTLLEEIDFMRRVHDQEIAELQAMASRDTTPENREYFKNELASAIRDIRAEYDQICNVNRMDMESWYKLKVQEIQTQSTRQNLEQNYAKKRLRVQLTDLRGKLADLEGRNSLLKQTQELNYQLEDDQRSYEAALNDRDAQIRKMDEECQALMMLLDTKQTLDAEIAIYRKMLEGEENRAGLRQLVEQVVKTHGLTQVDETESLRVLKGETASRTSFQRSAKGNVSIQETAPDGRYVVLENTHRSKEEAIGEWKLKRKIDGKREIVYTLPRDFILRPGKSVKIWARGQGGIHSPPEQLVFDLEDTFGSGSNVQTILFNREGEERATHIQRSSHTI
InterPro domains: - IPR039008: Intermediate filament, rod domain (domain) [1-342]
- IPR016451: Intermediate filament, ifa/ifb (family) [1-496]
- IPR001322: Lamin tail domain (domain) [375-493]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [328-336]
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [351-496]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)
Protein: 1-Cys peroxiredoxin PER1 (EC 1.11.1.24) (Rehydrin homolog) (Thioredoxin peroxidase) (Thioredoxin-dependent peroxiredoxin) (A2SZW8)
Organism: Zea mays (Maize)
Function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O04005}. Cytoplasm {ECO:0000250|UniProtKB:O04005}.
Sequence: MPGLTIGDTVPNLELDSTHGKIRIHDYVGDGYAIIFSHPADFTPVCTTEMAAMAGYAKEFEKRGVKLLGISCDDVESHRQWTKDVEAYGGKQQQQQATTTKVTFPILADPARDAIRQLNMVDPDEKDAAGRSMPSRALHVVGPDKAVKLSFLYPATTGRNMDEVLRAVDSLLTAAKHGGKVATPANWKPGECAVIAPGVSDEEARKMFPQGFETADLPSKKGYLRFTKV
InterPro domains: - IPR024706: Peroxiredoxin, AhpC-type (family) [1-229]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [4-228]
- IPR013766: Thioredoxin domain (domain) [4-173]
- IPR019479: Peroxiredoxin, C-terminal (domain) [174-210]
- IPR045020: 1-Cys peroxiredoxin (family) [6-228]
- IPR000866: Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant (domain) [6-148]
Interaction partners: - NADPH-dependent thioredoxin reductase 3
- Glutaredoxin-dependent peroxiredoxin
- Glutaredoxin-dependent peroxiredoxin
- Glutaredoxin-dependent peroxiredoxin
- Uncharacterized protein
- Sulfiredoxin chloroplastic/mitochondrial
- Sulfiredoxin chloroplastic/mitochondrial
- sulfiredoxin
- O-fucosyltransferase family protein
- Thioredoxin reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0004601 (peroxidase activity), GO:0016491 (oxidoreductase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor), GO:0051920 (peroxiredoxin activity), GO:0140824 (thioredoxin-dependent peroxiredoxin activity), GO:0008379 (thioredoxin peroxidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006979 (response to oxidative stress), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0000302 (response to reactive oxygen species), GO:0042542 (response to hydrogen peroxide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: CUB-like domain-containing protein (O02360)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MSARFVAFLLITSNLIILSKTDDDFTCPTIHITKDTGMTGAIPAGATSMTKIPAGTDCTYIFDIPKGFAIKMETSAVYDVSPGDSIKFDYFYISSPAEKEVEYAVNQTLPYEVISKTGNLTFFATYTYIDMTNYQQVIKPTGTYFNATLETDKYFTVQAADNDQVVLKYGSRQTGFVDTSIYEVFVFDGNDILNSKYLGRLTELYRRPQYDVSSTSNTLTLLDLYGMPSDSLLLGNDASTVENMGQYSVFVIDSDKELDGYMGNYELEPDSWYTFICNDCSSFTIGAMTFDRKFENASGYIEVQGMSPTQKLQPVLKYPYSTNSNSSFPQLIPSPMATFHIHNASVTFVVKPGVPQNDFAAAPGQSRSVYSPQIWNPAAEPKFDYTFSDPVKVYNFSINLQTVKLENDGDELDVQVGSVDGLTTLDKKYNKDTKSDAYLSGIGRYLNLKYTGSKTSEVILNFVMIDRLNPDGTTQSPGTTVVPSGSFSTAPIVTSVSTRATRVSSSTAPVVSTVTSTITSQSIVTTNKSSSPITSKTTTSINVSSSTTKSTRPMQSTTTYQKLAQASSTASTTPIPITTQNISTASIATPSTKTPITPSLITTRSSTTKLSPIVITKSSLAYTATPTSAAPSTSALTITTHTTPIPGVLTSKTTSKTVDLTTATQSVQTPISTDPILHHTTPSSFTIGTTQFFTEISTVNPKRLTGSTATSVHVETTTKGTSSLFSAGFLIIVISALTL
InterPro domains: - IPR003366: CUB-like domain (domain) [23-131]
Interaction partners: - DAF-16/FOXO Controlled, germline Tumor affecting
- IgGFc_binding domain-containing protein
- IgGFc-binding protein-like
- CUB-like domain-containing protein
- CUB-like domain-containing protein
- CUB-like domain-containing protein
- CUB-like domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Aminoglycoside 2'-N-acetyltransferase (EC 2.3.1.-) (AAC(2')-Ic) (P9WQG9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: May catalyze the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides and confer resistance to aminoglycosides (By similarity). In vitro assays show no significant increase of resistance to aminoglycosides, possibly due to low expression in a heterologous system.
Sequence: MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW
InterPro domains: - IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [12-181]
- IPR000182: GNAT domain (domain) [11-162]
Interaction partners: - Carboxyltransferase domain-containing protein
- Carboxyltransferase domain-containing protein
- Proline-rich antigen homolog
- Bifunctional AAC/APH
- Probable periplasmic iron-transport lipoprotein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0006525 (arginine metabolic process), GO:0006526 (arginine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)