Protein: Klotho (F1RC43)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Single-pass membrane protein
Sequence: MKVTWIPLPLVLFCQFQGTASDPGAGQHTWDTFSKLPYPDDKAFLYDTFPDKFMWAVGTAAYSVEGAWEKDGKGKSIWDTFTRGGTRVSRGDVGSDSYHNIPGDLRALQQLGVSHYRFSLSWPRIFSNGTKESYNDKGVEYYKNLIRGLKDIKVQPVVTLYHWDLPDSLQTLFGGWSNSVMVELFRDYADFCFKTFGSDVKFWITIDNPFVVAWHGYGTGVVAPGIKNDSDLPFRVGHNLLKAHAAAWHLYDERYRAAQGGRVSMALGSHWIKPSRTRQESRKACQRSLNFVLGWFARPLFVDGDYPPCMKDNLTHRLPSFTEAESAYVNGTADFFALSHGPALSFQLINDSLRFGQTEDLGLRMLLYWVRAEYNNPPIFVVESGWYGSGNTKTKDAKHMYYLKRFIMETLKAIHVDRVNVIGYTAWSLLDGYEWYREYAIRRGLFYVDFNTPDLKREPKASATFYSKLIEKNGFPQLPENRPAQGAFPCDFAWGVAANSIQVDTTPTQFTDTNVYVWNISGNGELKKLPGLQAPHLRRTPHCADYGSIRQQVSDLLRMQVSHFHFSLNWSSIVPTGHVSDANETLLRYYYCFVSELQKVNITPVVTLWHHTGKLSSLPAPMEASDGWQSEKTVQAFVDYARLCFQRLGAHVKLWITLNEPNDEDLEYTVGHQLLRAHALAWHVYDREFRKAQGGKASLVLHMDWVEPAFSFNREDVAPADRVLDFRVGWFAEPIFGKGDYPAVMRSWLQQRNTIDLFNYHLPTFSEEDRLLVKGTYDFFAISHFTTSMVYDGVEDKYTFKDKLQVQLISDVTWIMSPRRNSPVVPWGLRKALNWVNSRYKGVPIYVMANGVQEDTARFRDSLRSYYLYNYVNEALKAYMLDAVNLKGYFAYAFSDQRDPGFGMYGHVQEEVISKSSLGHYKNIIRHNGFPAPSTSQHQCPHAPAQGSGRYVLTKKPVVGFLSLVSSCMLITMCLVIYYAFKRHKLTTKK
InterPro domains: - IPR001360: Glycoside hydrolase family 1 (family) [46-929]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [41-926]
Interaction partners: - Beta-glucuronidase
- Aldo-keto reductase family 1 member A1-A
- Aldo-keto reductase family 1 member A1-B
- Glucuronokinase with putative uridyl pyrophosphorylase
- Fibroblast growth factor receptor 1-A
- Fibroblast growth factor
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 2
- Inositol oxygenase
- Fibroblast growth factor receptor 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0008284 (positive regulation of cell population proliferation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071774 (response to fibroblast growth factor), GO:1902533 (positive regulation of intracellular signal transduction), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:0044344 (cellular response to fibroblast growth factor stimulus), GO:0008543 (fibroblast growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)