Protein: Proteasome subunit beta type-1 (Q6DRF3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation
Subcellular location: Cytoplasm. Nucleus
Sequence: MISAQAYGENGKMKEYHYTGPVEHKFSPYAFNGGTVLAVAGEDFAIVASDTRLSEGYSIHSRDSPKCYKLTDTTVLGCSGFHGDCLTLTKIIEARLKMYKHSNNKSMTSGAIAAMLSTILYGRRFFPYYVYNIIGGLDEEGRGAVYSFDPVGSYQRDTYKAGGSASAMLQPLLDNQIGFKNMENVEHVPLTQEKAVQLVKDVFISAAERDVYTGDALKVCIVSKEGIKEEIVPLRKD
InterPro domains: - IPR029055: Nucleophile aminohydrolases, N-terminal (homologous_superfamily) [25-237]
- IPR023333: Proteasome B-type subunit (family) [19-230]
- IPR016050: Proteasome beta-type subunit, conserved site (conserved_site) [37-84]
- IPR001353: Proteasome, subunit alpha/beta (family) [31-222]
Interaction partners: - Proteasome subunit alpha type
- 26S proteasome non-ATPase regulatory subunit 12
- Proteasome subunit beta
- Proteasome subunit alpha type
- Proteasome subunit alpha type
- Proteasome subunit alpha type
- Proteasome subunit beta
- Proteasome subunit beta
- Proteasome subunit alpha type
- 26S proteasome regulatory subunit 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0043207 (response to external biotic stimulus), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0006952 (defense response), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048863 (stem cell differentiation), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0014032 (neural crest cell development), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)