Protein: F-box only protein 17 (F-box only protein 26) (Q96EF6)
Organism: Homo sapiens (Human)
Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.
Sequence: MGARLSRRRLPADPSLALDALPPELLVQVLSHVPPRSLVTRCRPVCRAWRDIVDGPTVWLLQLARDRSAEGRALYAVAQRCLPSNEDKEEFPLCALARYCLRAPFGRNLIFNSCGEQGFRGWEVEHGGNGWAIEKNLTPVPGAPSQTCFVTSFEWCSKRQLVDLVMEGVWQELLDSAQIEICVADWWGARENCGCVYQLRVRLLDVYEKEVVKFSASPDPVLQWTERGCRQVSHVFTNFGKGIRYVSFEQYGRDVSSWVGHYGALVTHSSVRVRIRLS
InterPro domains: - IPR039752: F-box only protein (family) [4-276]
- IPR007397: F-box associated (FBA) domain (domain) [93-275]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [8-69]
- IPR001810: F-box domain (domain) [15-62]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [97-274]
Interaction partners: - S-phase kinase-associated protein 1
- Cullin-1
- COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 7b
- E3 ubiquitin-protein ligase RBX1
- COP9 signalosome complex subunit 6
- COP9 signalosome complex subunit 2
- F-box/WD repeat-containing protein 2
- NEDD8-conjugating enzyme Ubc12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0031146 (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)