wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cytochrome P450 71D18 (EC 1.14.14.51) ((-)-(4S)-Limonene-6-hydroxylase) (Q9XHE8)
Organism: Mentha spicata (Spearmint)
Function: Hydroxylates (-)-(4S)-limonene to (-)-trans-carveol, a precursor of (-)-carvone, responsible for the typical spearmint flavor note. Fluorinated substrate analogs are hydroxylated with the same regio- and stereochemistry.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MELDLLSAIIILVATYIVSLLINQWRKSKSQQNLPPSPPKLPVIGHLHFLWGGLPQHVFRSIAQKYGPVAHVQLGEVYSVVLSSAEAAKQAMKVLDPNFADRFDGIGSRTMWYDKDDIIFSPYNDHWRQMRRICVTELLSPKNVRSFGYIRQEEIERLIRLLGSSGGAPVDVTEEVSKMSCVVVCRAAFGSVLKDQGSLAELVKESLALASGFELADLYPSSWLLNLLSLNKYRLQRMRRRLDHILDGFLEEHREKKSGEFGGEDIVDVLFRMQKGSDIKIPITSNCIKGFIFDTFSAGAETSSTTISWALSELMRNPAKMAKVQAEVREALKGKTVVDLSEVQELKYLRSVLKETLRLHPPFPLIPRQSREECEVNGYTIPAKTRIFINVWAIGRDPQYWEDPDTFRPERFDEVSRDFMGNDFEFIPFGAGRRICPGLHFGLANVEIPLAQLLYHFDWKLPQGMTDADLDMTETPGLSGPKKKNVCLVPTLYKSP
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [27-491]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [429-438]
- IPR001128: Cytochrome P450 (family) [35-484]
- IPR002401: Cytochrome P450, E-class, group I (family) [63-459]
- IPR052306: Cytochrome P450 71D (family) [57-494]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009314 (response to radiation), GO:0009416 (response to light stimulus), GO:0014070 (response to organic cyclic compound), GO:0033993 (response to lipid), GO:0070542 (response to fatty acid), GO:0009753 (response to jasmonic acid), GO:0009751 (response to salicylic acid), GO:0009411 (response to UV), GO:0010225 (response to UV-C)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Thioredoxin 3 (PfTRX3) (Q4VWQ3)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21203490}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MALICIGSVCFSLFHIGVIILLIINYFSSHIKKIFPSFFKNPNKEEIDKHIGNILEAKRKNKQLEQSIYIELKNTGSLNQVFSSTQNSSIVIKFGAVWCKPCNKIKEYFKNQLNYYYVTLVDIDVDIHPKLNDQHNIKALPTFEFYFNLNNEWVLVHTVEGANQNDIEKAFQKYCLEKAK
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [67-174]
- IPR013766: Thioredoxin domain (domain) [86-170]
Interaction partners: - Small ribosomal subunit protein eS30
- UV excision repair protein RAD23
- Ribosomal protein S27a, putative
- Polyubiquitin
- Ubiquitin-like protein, putative
- Ubiquitin domain-containing protein DSK2, putative
- Ubiquitin-like protein nedd8 homologue, putative
- Putative cell division cycle ATPase
- Cell division cycle protein 48 homologue, putative
- AAA family ATPase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0015035 (protein-disulfide reductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Large ribosomal subunit protein uL22 (50S ribosomal protein L22) (P61175)
Organism: Escherichia coli (strain K12)
Function: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Sequence: METIAKHRHARSSAQKVRLVADLIRGKKVSQALDILTYTNKKAAVLVKKVLESAIANAEHNDGADIDDLKVTKIFVDEGPSMKRIMPRAKGRADRILKRTSHITVVVSDR
InterPro domains: - IPR005727: Large ribosomal subunit protein uL22, bacterial/chloroplast-type (family) [1-110]
- IPR036394: Ribosomal protein uL22 superfamily (homologous_superfamily) [1-110]
- IPR001063: Large ribosomal subunit protein uL22 (family) [5-108]
- IPR018260: Large ribosomal subunit protein uL22, conserved site (conserved_site) [83-107]
- IPR047867: Large ribosomal subunit protein uL22, bacterial/organelle-type (family) [2-109]
Interaction partners: - Large ribosomal subunit protein uL18
- Large ribosomal subunit protein uL4
- Small ribosomal subunit protein uS13
- Elongation factor Tu 1
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein uL6
- Large ribosomal subunit protein uL30
- GTP pyrophosphokinase
- Large ribosomal subunit protein uL14
- DNA-directed RNA polymerase subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0019843 (rRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Truncated granzyme M (Q9R1W7)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MTHQGGPRARALQELDLRVLDTQICNNSRFWNGVLIDSMLCLKAGSKSQAPCKGDSGGPLVCGKGQVDGILSFSSKTCTDIFKPPVATAVAPYSSWIRKVIGRWSPQSLV
InterPro domains: - IPR033116: Serine proteases, trypsin family, serine active site (active_site) [50-61]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [2-91]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [3-103]
- IPR001254: Serine proteases, trypsin domain (domain) [1-102]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048583 (regulation of response to stimulus), GO:0009605 (response to external stimulus), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0051707 (response to other organism), GO:0002684 (positive regulation of immune system process), GO:0006952 (defense response), GO:0050778 (positive regulation of immune response), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0006956 (complement activation), GO:0045087 (innate immune response), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0098542 (defense response to other organism)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: M6, isoform G (M6-D isoform) (H9A9K2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MGECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVFHLRLIWIEAVQMIFVIIGAGMAALGFMILFVGFLATGATRYKVYRAWRSRVGGRISCAVLMGITYLLNFVWSLILCFLVVVTFIYTMFWNMCTSVEHSQSCIDLTQFRKPLNIHKDKPSNTTSIPQILCSRQTRNWRT
InterPro domains: - IPR001614: Myelin proteolipid protein PLP (family) [2-160]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:2000026 (regulation of multicellular organismal development), GO:0007349 (cellularization), GO:0048468 (cell development), GO:0007291 (sperm individualization), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0007283 (spermatogenesis), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0045995 (regulation of embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: F26K24.14 protein (Q9SF14)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MESPIKCCDCGCDCCSSSPGSWIRSVKKRRHDELQTEKRFSIPELDDLDMFSNPRVQIENECELLRETVSNQQQTIQDLYHELEQERIASSTAADETVKMIQTLEREKAKIDLELKQLQRSVDETLNYENQEIEALENMVYQRDQTIQALTFETQAYKHRMMSFGLTEAEADGERSLLSRNPSMIDFSSEYDCPTQDYPPLKCNINENQDPLEADIYVADDENYPPADSPHGRVHLKTLDRRLSQMETNPSFTQLNRGRDVSEKGMVGESPRRQRHFRRISPTGSSSSHLGASKELRPDVFVDSPRSQSYSSKKMEDVSYTENNNAKDDLSEIGDDMSDRVYTIDSVHHSSVAHSGGVAEQKIEDGASDGNVVFPREHTDLGDPDITKLYMRLQALEADRESMKHALLSMRTEKAQMVLLKEIAQHLSKEVVPQRRLPLRKASIAGPLTFTPVFKWITSFVSWKRKARRSKYMYGMSGNNIGLQMLLEKVPRSRKWRCLRSTQV
InterPro domains: - IPR007656: GTD-binding domain (domain) [60-158]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0017022 (myosin binding), GO:0032036 (myosin heavy chain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0051640 (organelle localization), GO:0051649 (establishment of localization in cell), GO:0051644 (plastid localization), GO:0016043 (cellular component organization), GO:0051656 (establishment of organelle localization), GO:0006996 (organelle organization), GO:0009657 (plastid organization), GO:0009658 (chloroplast organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155) (Q96P65)
Organism: Homo sapiens (Human)
Function: Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
InterPro domains: - IPR000611: Neuropeptide Y receptor family (family) [72-343]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [62-332]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [47-340]
Interaction partners: - Orexigenic neuropeptide QRFP
- Guanine nucleotide-binding protein G
- Galanin peptides
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008188 (neuropeptide receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007267 (cell-cell signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0099536 (synaptic signaling), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0099537 (trans-synaptic signaling), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane), GO:0005929 (cilium), GO:0098588 (bounding membrane of organelle), GO:0060170 (ciliary membrane), GO:0097730 (non-motile cilium)
Protein: Myelin basic protein (F8W3A0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Myelin membrane {ECO:0000256|ARBA:ARBA00004392}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004392}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004392}.
Sequence: MATASTSGQNPFGLGRKKKAPGVLDQISRFFGGDKKRKGKRPHHSSTRRRGDVNPVVHFFRSFGESRSRSPPKRWSTIF
InterPro domains: - IPR000548: Myelin basic protein (family) [1-75]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043209 (myelin sheath), GO:0005886 (plasma membrane)
Protein: Odorant receptor 85c (Q9VHQ6)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Sequence: MKFMKYAVFFYTSVGIEPYTIDSRSKKASLWSHLLFWANVINLSVIVFGEILYLGVAYSDGKFIDAVTVLSYIGFVIVGMSKMFFIWWKKTDLSDLVKELEHIYPNGKAEEEMYRLDRYLRSCSRISITYALLYSVLIWTFNLFSIMQFLVYEKLLKIRVVGQTLPYLMYFPWNWHENWTYYVLLFCQNFAGHTSASGQISTDLLLCAVATQVVMHFDYLARVVEKQVLDRDWSENSRFLAKTVQYHQRILRLMDVLNDIFGIPLLLNFMVSTFVICFVGFQMTVGVPPDIMIKLFLFLFSSLSQVYLICHYGQLIADASSSLSISAYKQNWQNADIRYRRALVFFIARPQRTTYLKATIFMNITRATMTDLLQVSYKFFALLRTMYIK
InterPro domains: - IPR004117: Olfactory receptor, insect (family) [2-387]
Interaction partners: - Odorant receptor 67b
- Odorant receptor 74a
- Odorant receptor 30a
- Odorant receptor 35a
- Odorant receptor 42a
- Odorant receptor 83a
- Odorant receptor 47a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005549 (odorant binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004984 (olfactory receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0051606 (detection of stimulus), GO:0042221 (response to chemical), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050877 (nervous system process), GO:0009593 (detection of chemical stimulus), GO:0007600 (sensory perception), GO:0050907 (detection of chemical stimulus involved in sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0050911 (detection of chemical stimulus involved in sensory perception of smell), GO:0007608 (sensory perception of smell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Histone H2A (Q6CK59)
Organism: Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000305|PubMed:32004465}. Chromosome {ECO:0000305|PubMed:32004465}.
Sequence: MSGKGGKAGSAAKASQSRSAKAGLTFPVGRVHRLLRKGNYAQRIGSGAPVYLTAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDDELNKLLGNVTIAQGGVLPNIHQNLLPKKSSKAKASQEL
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [1-130]
- IPR002119: Histone H2A (family) [3-123]
- IPR007125: Histone H2A/H2B/H3 (domain) [6-89]
- IPR032454: Histone H2A, C-terminal domain (domain) [92-125]
- IPR032458: Histone H2A conserved site (conserved_site) [22-28]
Interaction partners: - Histone H4
- Histone H3
- Ubiquitin-ribosomal protein eS31 fusion protein
- Histone H2B.1
- FACT complex subunit SPT16
- Histone H2A.Z
- Histone H2B.2
- Polyubiquitin
- Histone-lysine N-methyltransferase, H3 lysine-36 specific
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)