Protein: Anion exchange protein 2 (AE 2) (Anion exchanger 2) (Band 3-related protein 2) (B3RP-2) (Non-erythroid band 3-like protein) (Solute carrier family 4 member 2) (P23347)
Organism: Rattus norvegicus (Rat)
Function: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane. Plays an important role in osteoclast differentiation and function (By similarity). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:22310983}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10600827, ECO:0000269|PubMed:8141271}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEDEVGEAEGFRAPPQQPSPASSPSAVQFFLQEDEGTDRKAERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELQLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWLVLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSVSNDSEADSSSNNMTWAATTLAPDNSSASGQERPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV
InterPro domains: - IPR018241: Anion exchange, conserved site (conserved_site) [679-840]
- IPR002978: Anion exchange protein 2 (family) [17-476]
- IPR013769: Band 3 cytoplasmic domain (domain) [318-615]
- IPR001717: Anion exchange protein (family) [416-1066]
- IPR011531: Bicarbonate transporter-like, transmembrane domain (domain) [677-1213]
- IPR003020: Bicarbonate transporter, eukaryotic (family) [314-1233]
- IPR016152: Phosphotransferase/anion transporter (homologous_superfamily) [315-640]
Interaction partners: - Solute carrier family 12 member 2
- Cystic fibrosis transmembrane conductance regulator
- Aquaporin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019899 (enzyme binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015106 (bicarbonate transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0005452 (solute:inorganic anion antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0022008 (neurogenesis), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0048709 (oligodendrocyte differentiation), GO:0042063 (gliogenesis), GO:0014003 (oligodendrocyte development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)