Protein: Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Q9P6I5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Essential for recycling GMP and indirectly, cGMP.
Sequence: MTPQLSSSVASKLVTLKLKPVVVFGPSGVGKSTLLKRLLKDHGDKLGFSVSHTTRTPRAGEKDGIDYHFVTKEEFQKLVAEEKFVEWAVFSGNMYGTSIMAIQELEAVNKKAILDIDLQGVLQVKASPIDAQYVFLAPPSIEQLEVRLRGRGTENESAILQRLERARAEIEYSEKPGNFDALIVNDDVEKAYKQLEAICLSD
InterPro domains: - IPR008144: Guanylate kinase-like domain (domain) [18-200]
- IPR017665: Guanylate kinase (family) [20-199]
- IPR020590: Guanylate kinase, conserved site (conserved_site) [53-70]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [12-201]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [17-202]
Interaction partners: - Inosine triphosphate pyrophosphatase
- GMP synthase
- Adenine phosphoribosyltransferase
- Nucleoside diphosphate kinase
- Ribonucleoside-diphosphate reductase large chain
- Adenylate kinase
- Ribonucleoside-diphosphate reductase small chain
- Pyruvate kinase
- Golgi apyrase
- 3',5'-cyclic-nucleotide phosphodiesterase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016776 (phosphotransferase activity, phosphate group as acceptor), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0050145 (nucleoside monophosphate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0009117 (nucleotide metabolic process), GO:0046390 (ribose phosphate biosynthetic process), GO:0009132 (nucleoside diphosphate metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009185 (ribonucleoside diphosphate metabolic process), GO:0009135 (purine nucleoside diphosphate metabolic process), GO:0009133 (nucleoside diphosphate biosynthetic process), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0009188 (ribonucleoside diphosphate biosynthetic process), GO:0009179 (purine ribonucleoside diphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)