Protein: Interferon regulatory factor 4a (A0A8M1NI50)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MNLDGDCIMSVSCGNGKLRQWLIEQIDSGEYSGLVWENDEKTIFRIPWKHAGKQDYNRDEDAALFKAWALFKGKYREGLDKPDPPTWKTRLRCALNKSNDFDELVERSQLDISDPYKVYRIVPEGAKRGSKAISMEENTTHVTPLSYPMHSAYPALQPQMSGFMLPQERRDWREFGSDPPHTQTPHADLPYGQCPYPPSRSLPWHTAPCDNGYQISGSFYTYSPSESHPVAMDPSMRSAEAMAISDCRLHVSLFYRESLVKELTTSSPEGCRISSSASPGSPSSPSSPSEERLYGGAEPVLFPFPYPQSQRRGAEKLPNVLERGVLLWLSPDGLYAKRLCQGRVYWEGPLAPYADKPNKLEKEQTCKLMDTQQFLTELQGFIHHGRPMPRSQVILCFGDEFPDPQRQSKMITAQVEPMFARQLLYFASQTNGHYLRSYELQTPGSLPVEDYQRSLQHLTE
InterPro domains: - IPR019471: Interferon regulatory factor-3 (domain) [246-428]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [245-440]
- IPR019817: Interferon regulatory factor, conserved site (conserved_site) [36-69]
- IPR001346: Interferon regulatory factor, DNA-binding domain (domain) [11-124]
- IPR017855: SMAD-like domain superfamily (homologous_superfamily) [236-460]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [17-130]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [18-123]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0043207 (response to external biotic stimulus), GO:0009888 (tissue development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009615 (response to virus), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048882 (lateral line development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0008544 (epidermis development), GO:0007423 (sensory organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0048925 (lateral line system development), GO:0035315 (hair cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0048884 (neuromast development), GO:0006355 (regulation of DNA-templated transcription), GO:0048884 (neuromast development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0043010 (camera-type eye development), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)