Protein: DNA (cytosine-5-)-methyltransferase (A0A8M2BEF6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton. Nucleus
Sequence: MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLAGFFEEKQARYCIRFLDVFQPEDSASSVSGGLFSILKKFEIPASNMVAVYINDHELTSESVVSQIRELNPQVIDLGGLYSIPDTACSAGLQTHSVQVQELIANIYRHFSTGSTSNDNLKMLFAGIDGLKVHSNPLSNSEEFCVLVKRIHEMWSDLVSYFSSCDENNDNVKQICSQLENPKIRLTLMFLDQALGPLRAFGQHLQQSKSSVRADLVEILREASGLLRSYASSFLRPQAVIRYLKEQDPAILDNEAFCLPAAELSLGGVLEDFISAREEELADFLSTFYNECLAIYKTLTTSIAASLPLSDSVLRAISQLLSPAGRLKVTGKNIVDLAVRFGFCSKPEDSAKLNDEFLEYQLAEEENLSSTHSIERYWCTVLKTFPPTSVFKRLVLCLLVLPSPSLDATKIFAQAIENGDADQLDDSSSESDTDMTKELDSNDDNSLDNSELQISPIKNGIMKKSRRSTSETVQHSNAVKPCVVRLEKITSQREVNLKNDGAKNDGTLTSNTLKEDSIRGIHGWECSLRQKPQARTVFQAGAGTWSKPAIQDVDRKPEAVKNDLSNSTPSPRRGKRDQAYNDGKGFAVGELVWGKVKDFSLWPGLVVPWKGRIVPVSMRRVEWFGDGMFSEIHTDGLLPFGAFSKNFCSKSYEGLPTYKNAIYQILELAAERSGKLFPPSEKKGEEVKAMMDWAFGGFQPMGADGFLPSADSSASNKTESDSSVSDYQPPAKRKYVFKNRPSTQECNRDQMVQEVTSKGRKIEDFCLSCGSSNTEIFHPLFKGSLCIKCKENFTETLYRYDDDGYQSYCTVCCAGLEVILCGNASCCRCFCKDCLNVLVGPGTFDKLKEVDPWSCYVCLPSKCYGVLKLRTDWSVRVQEFFANNSAFEFEPHRVYPSIPAHKRRPIRVLSLFDGIATGYLVLKDLGFKLERYIASEICEDSIAVGMVKHEGKIEYVKDVRTITRKHLAEWGPFDLLIGGSPCNDLSMVNPARKGLFEGTGRLFFEYYRMLTMMRPKEDDDRPFFWLFENVVAMSAHDKADICRFLECNPVMIDAVKVSPAHRARYFWGNLPGMNRPVATSLTDNVDLQDCLESGRTAMFSKVRTITTKSNSIKQGKTGPLPVTMNGKEDYLWCTEMEKIFGFPKHYTDVNNMGRGQRQKVLGRSWSVPVIRHLFAPLKDYFACE
InterPro domains: - IPR025766: ADD domain (domain) [1070-1202]
- IPR001715: Calponin homology domain (domain) [15-117]
- IPR000313: PWWP domain (domain) [902-983]
- IPR040552: DNMT3, cysteine rich ADD domain, GATA1-like zinc finger (domain) [1063-1118]
- IPR018117: DNA methylase, C-5 cytosine-specific, active site (active_site) [1290-1302]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [756-768]
- IPR050390: DNA Cytosine-5 Methyltransferase (family) [680-1333]
- IPR049554: DNMT3, ADD domain, PHD zinc finger (domain) [1125-1174]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [1210-1500]
- IPR036872: CH domain superfamily (homologous_superfamily) [1-132]
- IPR001525: C-5 cytosine methyltransferase (family) [1222-1500]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0004518 (nuclease activity), GO:0003677 (DNA binding), GO:0004536 (deoxyribonuclease activity), GO:0004520 (DNA endonuclease activity), GO:0004519 (endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0006306 (DNA methylation), GO:0006304 (DNA modification), GO:0006305 (DNA alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)