Protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (O43150)
Organism: Homo sapiens (Human)
Function: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration
Subcellular location: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups
Sequence: MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [929-1004]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [300-414]
- IPR001452: SH3 domain (domain) [944-1006]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [420-538]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [415-547]
- IPR001849: Pleckstrin homology domain (domain) [305-399]
- IPR002110: Ankyrin repeat (repeat) [584-683]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [542-693]
- IPR043593: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein (family) [1-1006]
- IPR037844: ASAP, PH domain (domain) [297-403]
- IPR001164: Arf GTPase activating protein (domain) [421-543]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [28-328]
- IPR004148: BAR domain (domain) [33-266]
- IPR035677: ASAP2, SH3 domain (domain) [948-1003]
Interaction partners: - ADP-ribosylation factor 6
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
- Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
- Protein-tyrosine kinase 2-beta
- Paxillin
- ADP-ribosylation factor 5
- Poly(A) polymerase beta
- SH3 domain-containing kinase-binding protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)