Protein: Ubiquitin-like-specific protease 1 (EC 3.4.22.-) (O42957)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: A cysteine protease that proteolytically removes the C-terminus of pmt3.
Sequence: MIGKRNASKRTRQDDCITYEEYQRKRKKTFLNTFVNICSRTVTYAKLFLTKTPISELDRIAGEAIPSNSNSTNSKLEPSTKAPESRFSHINSKTERGYVTVESDMSSHNTLDRNSKPTVSHSYTNSSKDEKFLDPIALQNLFSPASDTHSQNIHDEALSPSSFRVSRSRYFPRPHRSSKNLSVSNRLQLAVFKETTSSTLSHGNSVEADEINSFNPTPFSSSPLHFTNSSPNPNSDIVTPDKQLDVVSEHARYKHLPFTATLRKKSPHDSTSRKASFRFVQSDQQPARNIVTSDIQNEKSLLLLIRDLKEKQTESFQDWNEVDFLQLKGLEISPPPTRPKFIPELEFPDNARKRALKYLNQSNSVSSSEPIITKFNIPITLKDLHTLRNRQWLNDEVINFYMNLISERSKIDSSLPRVHGFNTFFYTSLQRRGYAGVRRWAKKARVNIADMDAVFIPVHLDVHWCMAVINKSKKRFEYWDSLAGSPGKVFDLLRDYYIAETKGAVDVSDWENFMDDNSPRQRNGHDCGVFACKTAECVSRNVPVQFSQNDMPELRIKMAASIIDAQIY
InterPro domains: - IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [346-564]
- IPR003653: Ulp1 protease family, C-terminal catalytic domain (domain) [377-562]
Interaction partners: - Ubiquitin-like protein pmt3/smt3
- SUMO-conjugating enzyme ubc9
- Ubiquitin-activating enzyme E1-like
- Importin subunit beta-3
- E3 SUMO-protein ligase pli1
- Ubiquitin-like-specific protease 2
- Ran GTPase-activating protein 1
- Pre-rRNA-processing protein las1
- Polynucleotide 5'-hydroxyl-kinase grc3
- Importin subunit alpha-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071704 (organic substance metabolic process), GO:0022402 (cell cycle process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1903047 (mitotic cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0044770 (cell cycle phase transition), GO:0036211 (protein modification process), GO:0044772 (mitotic cell cycle phase transition), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis), GO:0044839 (cell cycle G2/M phase transition), GO:0070646 (protein modification by small protein removal), GO:0000086 (G2/M transition of mitotic cell cycle), GO:0070647 (protein modification by small protein conjugation or removal), GO:0018193 (peptidyl-amino acid modification), GO:0018205 (peptidyl-lysine modification), GO:0016926 (protein desumoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0031974 (membrane-enclosed lumen), GO:0034399 (nuclear periphery), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)