Protein: Integrator complex subunit 10 (Int10) (Q9NVR2)
Organism: Homo sapiens (Human)
Function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:39032490}.
Sequence: MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTMLVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEIDRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESWELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSISQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKVKPKFRKGSDLKLLPCTSKAIMPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRGENLFLKAVNKICQQGNFQYENFFNYVTNIDMLEEFAYLRTQEGGKIHLELLPNQGMLIKHHTVTRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQTLT
InterPro domains: - IPR026164: Integrator complex subunit 10 (family) [1-710]
Interaction partners: - Integrator complex subunit 6
- Integrator complex subunit 3
- Integrator complex subunit 5
- Integrator complex subunit 1
- Integrator complex subunit 11
- Integrator complex subunit 9
- Integrator complex subunit 14
- Integrator complex subunit 7
- Integrator complex subunit 4
- Integrator complex subunit 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0046483 (heterocycle metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051236 (establishment of RNA localization), GO:0043170 (macromolecule metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0046907 (intracellular transport), GO:0006139 (nucleobase-containing compound metabolic process), GO:0006403 (RNA localization), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0009059 (macromolecule biosynthetic process), GO:0050658 (RNA transport), GO:1901362 (organic cyclic compound biosynthetic process), GO:0071705 (nitrogen compound transport), GO:0019438 (aromatic compound biosynthetic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0022607 (cellular component assembly), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0006913 (nucleocytoplasmic transport), GO:0016070 (RNA metabolic process), GO:0000723 (telomere maintenance), GO:0006406 (mRNA export from nucleus), GO:0006405 (RNA export from nucleus), GO:0051276 (chromosome organization), GO:0015931 (nucleobase-containing compound transport), GO:0051028 (mRNA transport), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0050657 (nucleic acid transport), GO:0006352 (DNA-templated transcription initiation), GO:0006351 (DNA-templated transcription), GO:0006354 (DNA-templated transcription elongation), GO:0034660 (ncRNA metabolic process), GO:0006361 (transcription initiation at RNA polymerase I promoter), GO:0006363 (termination of RNA polymerase I transcription), GO:0016072 (rRNA metabolic process), GO:0098781 (ncRNA transcription), GO:0006368 (transcription elongation by RNA polymerase II), GO:0009303 (rRNA transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0005667 (transcription regulator complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0090575 (RNA polymerase II transcription regulator complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)