Protein: Vacuolar protein sorting-associated protein VTA1 homolog (SKD1-binding protein 1) (SBP1) (Q9CR26)
Organism: Mus musculus (Mouse)
Function: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:15173323}. Endosome membrane {ECO:0000269|PubMed:15173323}; Peripheral membrane protein {ECO:0000269|PubMed:15173323}.
Sequence: MAALAPLPPLPAQFKSIQHHLRTAQEHDKRDPVVAYYCRLYAMQTGMKIDSKTPECRKFLSKLMDQLEALKKQLGDNEAVTQEIVGCAHLENYALKMFLYADNEDRAGRFHKNMIKSFYTASLLIDVITVFGELTDENVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEENDVEENEDVGATSLPTQPPQPSSSSAYDPSNLAPGSYSGIQIPPGAHAPANTPAEVPHSTGVTSNAVQPSPQTVPAAPAVDPDLYTASQGDIRLTPEDFARAQKYCKYAGSALQYEDVGTAVQNLQKALRLLTTGRE
InterPro domains: - IPR044538: Vacuolar protein sorting-associated protein Vta1-like (family) [8-306]
- IPR039431: Vta1/callose synthase, N-terminal (domain) [16-158]
- IPR023175: Vta1/Callose synthase, N-terminal domain superfamily (homologous_superfamily) [1-162]
- IPR041212: Vta1, C-terminal (domain) [268-305]
Interaction partners: - Charged multivesicular body protein 5
- Vacuolar protein sorting-associated protein 4B
- Vacuolar protein sorting-associated protein 4A
- Charged multivesicular body protein 1a
- Charged multivesicular body protein 1B1
- IST1 homolog
- Charged multivesicular body protein 1B2
- Pre-mRNA-splicing factor SPF27
- GTP cyclohydrolase 1
- Charged multivesicular body protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009894 (regulation of catabolic process), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0010256 (endomembrane system organization), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0016192 (vesicle-mediated transport), GO:0043933 (protein-containing complex organization), GO:0031329 (regulation of cellular catabolic process), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0048193 (Golgi vesicle transport), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0065003 (protein-containing complex assembly), GO:0007041 (lysosomal transport), GO:0016050 (vesicle organization), GO:0071985 (multivesicular body sorting pathway), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0000045 (autophagosome assembly), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)