Protein: UDP-xylose and UDP-N-acetylglucosamine transporter (ER GDP-fucose transporter) (Solute carrier family 35 member B4 homolog) (Q9W429)
Organism: Drosophila melanogaster (Fruit fly)
Function: Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19948734}; Multi-pass membrane protein {ECO:0000269|PubMed:19948734}.
Sequence: MALNLKALLGMLFVFIGCCSNVVFLELIIQIDPGAGNLITFAQFLFIALEGLVFTSKFFTVRPKIALKDYVILVALFFGANVCNNYAFNFNIPMPLHMIFRSGSLMANMIMGIVLLKKRYNLRQYSSVAMITAGIILCTLVSSGDVKDNTHHSLKVDTSYSDFFWWTVGIGLLTIALLVTAYMGIYQEVIYKKYGKHPSEALFFTHMLPLPGFLIMAGNIVQHFGIAWSSEPVAVPLLGAIGLEWKFPLMLFYLLCNVVTQYVCISAVYVLTTECASLTVTLVVTLRKFVSLLFSIIYFRNPFTLNHWVGTILVFFGTILFANVINQVRDAYRARSSRKTHFDTAPLAKKVE
InterPro domains: - IPR037185: Multidrug transporter EmrE superfamily (homologous_superfamily) [44-141]
- IPR013657: SLC35B1-4/HUT1 (family) [7-328]
Interaction partners: - UDP-sugar transporter UST74c
- GDP-fucose transporter, Golgi
- AMP deaminase
- Adenosine 3'-phospho 5'-phosphosulfate transporter 1
- UDP-galactose transporter senju
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0005338 (nucleotide-sugar transmembrane transporter activity), GO:0015165 (pyrimidine nucleotide-sugar transmembrane transporter activity), GO:0005459 (UDP-galactose transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0065007 (biological regulation), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0032506 (cytokinetic process), GO:0007276 (gamete generation), GO:0000910 (cytokinesis), GO:0140013 (meiotic nuclear division), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0033206 (meiotic cytokinesis), GO:0007140 (male meiotic nuclear division), GO:0007112 (male meiosis cytokinesis), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0010256 (endomembrane system organization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0061024 (membrane organization), GO:0033363 (secretory granule organization), GO:0016050 (vesicle organization), GO:0048284 (organelle fusion), GO:0061025 (membrane fusion), GO:0006897 (endocytosis), GO:0007009 (plasma membrane organization), GO:0000280 (nuclear division), GO:0045026 (plasma membrane fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0005797 (Golgi medial cisterna)