Protein: Probable D-lactate dehydrogenase, mitochondrial (DLD) (Lactate dehydrogenase D) (EC 1.1.2.4) (Q7TNG8)
Organism: Mus musculus (Mouse)
Function: Involved in D-lactate, but not L-lactate catabolic process.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:12127981}.
Sequence: MAMLLRVATQRLSPWRSFCSRGSQGGLSQDFVEALKAVVGSPHVSTASAVREQHGHDESMHRCQPPDAVVWPQNVDQVSRVASLCYNQGVPIIPFGTGTGVEGGVCAVQGGVCINLTHMDQITELNTEDFSVVVEPGVTRKALNTHLRDSGLWFPVDPGADASLCGMAATGASGTNAVRYGTMRDNVINLEVVLPDGRLLHTAGRGRHYRKSAAGYNLTGLFVGSEGTLGIITSTTLRLHPAPEATVAATCAFPSVQAAVDSTVQILQAAVPVARIEFLDDVMMDACNRHSKLNCPVAPTLFLEFHGSQQTLAEQLQRTEAITQDNGGSHFSWAKEAEKRNELWAARHNAWYAALALSPGSKAYSTDVCVPISRLPEILVETKEEIKASKLTGAIVGHVGDGNFHCILLVDPDDAEEQRRVKAFAENLGRRALALGGTCTGEHGIGLGKRQLLQEEVGPVGVETMRQLKNTLDPRGLMNPGKVL
InterPro domains: - IPR016167: FAD-binding, type PCMH, subdomain 1 (homologous_superfamily) [6-119]
- IPR006094: FAD linked oxidase, N-terminal (domain) [66-202]
- IPR016166: FAD-binding domain, PCMH-type (domain) [62-242]
- IPR016169: FAD-binding, type PCMH, subdomain 2 (homologous_superfamily) [121-243]
- IPR004113: FAD-binding oxidoreductase/transferase, type 4, C-terminal (domain) [243-483]
- IPR016171: Vanillyl-alcohol oxidase, C-terminal subdomain 2 (homologous_superfamily) [444-484]
- IPR036318: FAD-binding, type PCMH-like superfamily (homologous_superfamily) [28-243]
- IPR016164: FAD-linked oxidase-like, C-terminal (homologous_superfamily) [246-484]
Interaction partners: - L-lactate dehydrogenase C chain
- L-lactate dehydrogenase
- L-lactate dehydrogenase B chain
- L-lactate dehydrogenase A chain
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- NADP-dependent malic enzyme
- Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
- Pyruvate kinase PKM
- NADP-dependent malic enzyme, mitochondrial
- Pyruvate carboxylase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0006089 (lactate metabolic process), GO:0016054 (organic acid catabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)