wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Anion transporter ABTS-2 (Bicarbonate transporter-like transmembrane domain-containing protein) (G5EGB9)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MPELLCRTERVEHARNFKTEVRGLMDVDHLIERACIHRNMNHSHIHTILLSLFSDLSSRFPQEKFDLALFKNAVFSVSDRDSRAPRLHHKLQSYSGTDFFDVNQTWIVTYAQLDGLKQSHMALATLEDATNLGLEMEEARTVVLILSPSYEKHTKSAAEIARTFATLLMNDTLRQSVNDAADDDQLRDLLTEYAKGLSQQLTIQVNGKPIADDDDEYESKNSSFCPYYPFRGLVKDFKRRMANYKSDYLDGIKDRRSVSKVISTAVFLIFTILPTSIAYGMLNENNTNGAINVQKVVLGQWIGSLLFGIFGGQQLLILSTTAPLSIYIAVIYQVAQTNDWDFFQMYASVGIYAMGLLILASVFQLASLMKFTTRSTEEIFSVFIALALIIKAIMAIVHVYTHGYLGCINNVAGDLCDPAEPLLFIFLLFGTTWLSMTIISFRSSPYLSRWKRDLVSDYALPIAVLVFSFISFFGFSDVKKEQFQIFSRETDAFFVPFFNLPAEAQLPAVGLAIPLSILFFMDQLLVTNTVDNKDNKLKKGSAHHWDLLVVGVLNIGLSIFGLPWMHGALPSAYLHLKALSDVEDRLHNGYIQTVIVHVRETRLATLIAHIIMIPIYFFLVPHITVFIPTSIFNGVFLFMAFSSLTGNEFWERILLIFTEQRAYPPTHYIRRVPQRVVHQFTIIEFIQLVILVAIGFAQYHYVEMVFPIVIAAFIPFRHFFLPLFIRKQYLEAIDGQH
InterPro domains: - IPR016152: Phosphotransferase/anion transporter (homologous_superfamily) [20-198]
- IPR003020: Bicarbonate transporter, eukaryotic (family) [102-736]
- IPR011531: Bicarbonate transporter-like, transmembrane domain (domain) [229-736]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015267 (channel activity), GO:0005372 (water transmembrane transporter activity), GO:0015250 (water channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098656 (monoatomic anion transmembrane transport), GO:0098661 (inorganic anion transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:0006820 (monoatomic anion transport), GO:1902476 (chloride transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)
Protein: Sad1 and UNC84 domain containing 1 (A0A8I6ALL7)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus inner membrane {ECO:0000256|ARBA:ARBA00004540}.
Sequence: MDFSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHRLEPVFDSPRMSRRSLRLITTTAAYSSGDGQTVDTHISTSRATPAKGRETRTVKQRSASKPAFSINHLSGKGLSSSTSHDSSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARTDALTAHSAVHGPTSRVYSRDRTLRPRGASFYLDRTLWLAKYTSSSFASFIVQLFQVVLMKLNFESETYKLKGYESRAYESQSYETKSHESEAHLGHCGRMTAGELSRVDGESLCDLLVRALRRTRAAGWSVAEAMWSVLWLAVTAPGKAASGTFWWLGSGWYQFVTLISWLNVFLLTRCLRNICKVFVLLLPLLLLLGAGFSLWGQGNFFSLLPMLNWTAMQPAQRVDNPKDMHRPGPLSPSPPLKVDPMASQWPQESDMGQKIASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGREGLSLWVKDMVGQHLQEIGSIEPPDAKTDFLTLHHDHEVRLSSLEDVLRKLTEKSEAIQKELEETKLRAGSRDEEQPLLDRVQHLELELNLLKSQLSDWQHLRSSCEQADARIQETVQLMFSEDQPGGSLEWLLQKLSSRFVSKDELQVLLHDLELKLLQNITHHITVTGQAPTSEAIVSAMSQAGISGITEAQAHIIVNNALRLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALLSLFGVPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLSPTGNISSAPRDFAVYGLETEYQEEGQPLGRFTYDQEGDSLQMFHTLERPDQGFQIVELRVLSNWGHPEYTCLYRFRVHGEPIQ
InterPro domains: - IPR032680: SUN domain-containing protein 1, N-terminal (domain) [66-380]
- IPR045119: SUN domain-containing protein 1-5 (family) [48-876]
- IPR012919: SUN domain (domain) [716-877]
- IPR040994: SUN coiled coil domain 2 (domain) [641-699]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005521 (lamin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0001503 (ossification), GO:0009612 (response to mechanical stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: RNA helicase (EC 3.6.4.13) (Q68FX3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MATDSWALAVDEQEAAVKSMNSLQIKEEKVKADTNGVIKTSTTAEKTEEEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPSSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPADRHPQCLCLSPTYELALQTGKVIEQMGKFHPELKLAYAVRGNKLERGQKVGEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNIIKLKREEETLDTIKQYYVLCNNREEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN
InterPro domains: - IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [91-119]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [88-478]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [110-309]
- IPR011545: DEAD/DEAH-box helicase domain (domain) [116-279]
- IPR001650: Helicase, C-terminal domain-like (domain) [305-473]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016887 (ATP hydrolysis activity), GO:0004386 (helicase activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0008186 (ATP-dependent activity, acting on RNA), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0003724 (RNA helicase activity), GO:0003723 (RNA binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0010035 (response to inorganic substance), GO:0010941 (regulation of cell death), GO:0010038 (response to metal ion), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0010043 (response to zinc ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Uroporphyrinogen decarboxylase (EC 4.1.1.37) (C6KSS1)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MLKCLVTPLLICILTIKILCFINLKKLRFNIIKTETILNMNEVGEIYSRPENLKYEKFGRPQNDLILNVIENKNEEKKFKKIPLWIMRQAGRYLPEYVEIRKKYDFFEICKSPDLSSYVSIMPYDRFKTDMIVIFSDILIIFVAMGIDIKFVENLGPVFNLEIYNMNDFNKLNLNMKEIIDNLYYVYDSINLTKKKINNDVPILGFCGSPFTLFMYLTKNNKKTYEDSFKFLYEKPNDAHQIINKLSDICLNHLINQIDSGANIIQIFDSNAELVDKNIFNEFSIIYLKKVIEIIKKYRPNIYIILFIKNNFHDDIKNLKIDVLSITHKQLIDNTDQFYFKLFQNNIILQGALDPYILLLNDHELIQKHIIQMMKNITHKNKYIANLGHGILPTTKIKNVNLFIDTIRNNEWS
InterPro domains: - IPR038071: UROD/MetE-like superfamily (homologous_superfamily) [54-411]
- IPR006361: Uroporphyrinogen decarboxylase HemE (family) [75-409]
- IPR000257: Uroporphyrinogen decarboxylase (URO-D) (domain) [62-409]
Interaction partners: - Protoporphyrinogen oxidase
- coproporphyrinogen oxidase
- Ferrochelatase
- hydroxymethylbilane synthase
- Threonylcarbamoyladenosine tRNA methylthiotransferase
- Delta-aminolevulinic acid dehydratase
- tRNA 4-demethylwyosine synthase
- Triosephosphate isomerase
- 4-hydroxybenzoate polyprenyltransferase, putative
- Glucose inhibited division protein a homologue, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0042168 (heme metabolic process), GO:0046483 (heterocycle metabolic process), GO:0046148 (pigment biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0033013 (tetrapyrrole metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006783 (heme biosynthetic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033014 (tetrapyrrole biosynthetic process), GO:0006779 (porphyrin-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0020011 (apicoplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Matrix protein (Protein M) (Q9IK90)
Organism: Nipah virus
Function: Plays a crucial role in virion assembly and budding. Forms a shell at the inner face of the plasma membrane. Transits through the host nucleus before gaining the functional ability to localize and bud from the plasma membrane. Mediates together with fusion protein the incorporation of the glycoprotein to the viral particles. Participates also in the inhibition of the host interferon type I antiviral response by interacting with and thereby inhibiting host TRIM6.
Subcellular location: Virion. Host cytoplasm. Host cell membrane {ECO:0000269|PubMed:17005661, ECO:0000269|PubMed:19000317, ECO:0000269|PubMed:21085610}. Host nucleus {ECO:0000269|PubMed:21085610}. Note=During bud formation, associates at the inner side of the plasma membrane of infected cells. Nuclear-cytoplasmic trafficking is essential for budding and requires matrix ubiquitination. {ECO:0000269|PubMed:21085610}.
Sequence: MEPDIKSISSESMEGVSDFSPSSWEHGGYLDKVEPEIDENGSMIPKYKIYTPGANERKYNNYMYLICYGFVEDVERTPETGKRKKIRTIAAYPLGVGKSASHPQDLLEELCSLKVTVRRTAGSTEKIVFGSSGPLNHLVPWKKVLTSGSIFNAVKVCRNVDQIQLDKHQALRIFFLSITKLNDSGIYMIPRTMLEFRRNNAIAFNLLVYLKIDADLSKMGIQGSLDKDGFKVASFMLHLGNFVRRAGKYYSVDYCRRKIDRMKLQFSLGSIGGLSLHIKINGVISKRLFAQMGFQKNLCFSLMDINPWLNRLTWNNSCEISRVAAVLQPSIPREFMIYDDVFIDNTGRILKG
InterPro domains: - IPR000982: Matrix protein, N-terminal domain (domain) [17-184]
- IPR042540: Viral matrix protein, N-terminal domain (homologous_superfamily) [32-191]
- IPR042539: Viral matrix protein, C-terminal domain (homologous_superfamily) [192-352]
- IPR055413: Matrix protein, C-terminal, Paramyxoviridae (domain) [187-345]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019080 (viral gene expression), GO:0019083 (viral transcription), GO:0039695 (DNA-templated viral transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: NTF2 domain-containing protein (O18697)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MSFIAYPCAVPTQRQVPMSPPTTPRILMKLCPIMEIPIIGGPRQNGTYNVFIFDLKIRKFIPHRCSSCAVKILEDHLSPMYASGSVIFMRNEVTQEVEQYVYSFETGGFQQVDYPELVYSAEKFTESSFIVMIENSDGKKVLIERGGNEAVRKLEYRLGKCVEMPKVEVQLLAAEEFDDADPWSDNDSLSSEHLDYNETLPAFKTTFCQDFQMYVLYIITSRGHYEKYIYNQSTSQFEILDCEKCPDTTREVDLLPKYAEFCEEIQAYVIHVFNSFTDRMEQYVFDSKIQGFVEVNQPELKYDSSKDQDPTSSIFFVLKGTTVIMRGAQGRLKKEVYCSIKKHFVEVPNSVIKSFDTQFMEKKQKMDKKKKAKKIKKSKKKASKESQELDVLVEKIRLCDDPFSDGPSCSTSPDIPEDAPDDGMSILKQKFVESLTTLYGGSLPPYVQKELEQI
InterPro domains: - IPR039908: Protein sepa-1 (family) [20-424]
Interaction partners: - Cilia- and flagella-associated protein 157
- Protein CASP
- RILP-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0016043 (cellular component organization), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0000422 (autophagy of mitochondrion), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0007005 (mitochondrion organization), GO:0000423 (mitophagy), GO:0061912 (selective autophagy), GO:1903008 (organelle disassembly), GO:0061726 (mitochondrion disassembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Lymphocyte antigen 6A-2/6E-1 (Ly-6A.2/Ly-6E.1) (Stem cell antigen 1) (SCA-1) (T-cell-activating protein) (TAP) (P05533)
Organism: Mus musculus (Mouse)
Function: T-cell activation.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Sequence: MDTSHTTKSCLLILLVALLCAERAQGLECYQCYGVPFETSCPSITCPYPDGVCVTQEAAVIVDSQTRKVKNNLCLPICPPNIESMEILGTKVNVKTSCCQEDLCNVAVPNGGSTWTMAGVLLFSLSSVLLQTLL
InterPro domains: - IPR045860: Snake toxin-like superfamily (homologous_superfamily) [24-107]
- IPR016054: Ly-6 antigen/uPA receptor-like (domain) [25-118]
- IPR051445: Lymphocyte Antigen 6 Family Modulators (family) [2-134]
- IPR018363: CD59 antigen, conserved site (conserved_site) [28-78]
Interaction partners: - Lymphocyte antigen 6E
- Mast/stem cell growth factor receptor Kit
- Receptor-type tyrosine-protein phosphatase C
- Proto-oncogene tyrosine-protein kinase LCK
- Hematopoietic progenitor cell antigen CD34
- Lymphocyte antigen 6 family member C1
- Integrin alpha-M
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050792 (regulation of viral process), GO:0043903 (regulation of biological process involved in symbiotic interaction), GO:0048525 (negative regulation of viral process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:1903900 (regulation of viral life cycle), GO:0052372 (modulation by symbiont of entry into host), GO:1903901 (negative regulation of viral life cycle), GO:0046596 (regulation of viral entry into host cell), GO:0046597 (negative regulation of viral entry into host cell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: FAM10 family protein At4g22670 (Q93YR3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MDSTKLSELKVFIDQCKSDPSLLTTPSLSFFRDYLESLGAKIPTGVHEEDKDTKPRSFVVEESDDDMDETEEVKPKVEEEEEEDEIVESDVELEGDTVEPDNDPPQKMGDSSVEVTDENREAAQEAKGKAMEALSEGNFDEAIEHLTRAITLNPTSAIMYGNRASVYIKLKKPNAAIRDANAALEINPDSAKGYKSRGMARAMLGEWAEAAKDLHLASTIDYDEEISAVLKKVEPNAHKLEEHRRKYDRLRKEREDKKAERDRLRRRAEAQAAYDKAKKEEQSSSSRPSGGGFPGGMPGGFPGGMPGGFPGGMGGMPGGFPGGMGGMGGMPGGFPGGMGGGMPAGMGGGMPGMGGGMPAGMGGGGMPGAGGGMPGGGGMPGGMDFSKILNDPELMTAFSDPEVMAALQDVMKNPANLAKHQANPKVAPVIAKMMGKFAGPQ
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [85-257]
- IPR034649: Hsp70-interacting protein, N-terminal (domain) [2-43]
- IPR041243: STI1/HOP, DP domain (domain) [385-435]
- IPR006636: Heat shock chaperonin-binding (domain) [391-430]
- IPR019734: Tetratricopeptide repeat (repeat) [123-224]
Interaction partners: - Transcription elongation factor 1 homolog
- Heat shock 70 kDa protein 14
- Probable inactive receptor kinase At5g58300
- Probable plastid-lipid-associated protein 4, chloroplastic
- Probable plastid-lipid-associated protein 9, chloroplastic
- 14-3-3-like protein GF14 mu
- Probably inactive leucine-rich repeat receptor-like protein kinase IMK2
- Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial
- Camphor resistance CrcB family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0006457 (protein folding), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0010286 (heat acclimation), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Variant surface glycoprotein (VSG)-related, putative (Q57YT2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Sequence: MCGIKYCVVLFALVLRTSIFGEGKIVNEDEFGALCGMINFAKGALQRVEEAQEVNKSLTKIGSRCLELAGDVKLSNTCIDNNDESCEYSKVFWDAAKLSMSEGNAGKESLDDEKLEKVKQVASAAETIYGNMTKRHWVLNGDIIKQMLNRALYGIPHQPKKMRERSATRKRVCEGDVSQPEVNQGPVSLSRDLLCLCATDRKSRRKTKLCCENCVSGENRRVWRPRNDAQKRWNFLVSQCSNVEGHKEGFAKLVEKFRRSLNHRVDGCSGTMYVLGKHKKQLFWPLEFLSGYVPGPGVHYIINTRAGMVEDIPWLGELREIATLMGDLSEDNVEGRGLKSAIEKLEGDLEELFPTGGVRRG
InterPro domains: - IPR025932: Trypanosome variant surface glycoprotein, B-type, N-terminal domain (domain) [9-344]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0046812 (host cell surface binding), GO:0046789 (host cell surface receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: SD01032p (Q8T990)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Sequence: MQATKMRTPFAIQEILGLGAYQQQATASATPSEAPPSPAAYLRGFLPPGFSTPHEFRGHFQQHFGAQFAEQAAARGQEYASSLANASGDEQSPSKNSSSSGNGGSGGSGSGSGGGNPTSNGLGHLGSPTASNGGSGGGAGVGGSGGGSGTSGSSSSTSGNGGNGGSSGSRSSPAGPHHSAALAAHQHAAAAAAAAHHHAAAAAAAHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAHHAEAFLGAAGGAGGNPNSLLAAHGGDVLVGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKSAKEDESVAPWLLGMHKKSLEAAELLKSDESDRETPTSDDTNTSYSAGSTHNSPISSFSISRLLFDAPPPAAGSAGGKGHHHHHHHHKGHHHAHVHAQAQAHAHMLLHHQQQQQQQQQQQQHHHHLHAAENSLQQQQVAGTGSGSGSGSGSGTGAGSTGPPAHHPYNQQQHLHHLQQLQQQQQQQQQQAQQQQQHHHHQHHHSVHHMHHHNAAAGYAEAAVAAAAAAAAVAAAANARNAAAAAAVAAASASASAAVTIAESEAEEEQDDIEDMELDKDCEVEEDVEPVDNDTNTNNEHDNECDADADVEADVDADADADPEIDICDDHDEEMRLQEQLLLKVKQEQAHLGSR
InterPro domains: - IPR023339: CVC domain (domain) [343-394]
- IPR001356: Homeodomain (domain) [281-345]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [270-342]
- IPR017970: Homeobox, conserved site (conserved_site) [316-339]
- IPR052294: Visual system homeobox transcriptional regulators (family) [173-506]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0048856 (anatomical structure development), GO:0050794 (regulation of cellular process), GO:0008284 (positive regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation), GO:2000177 (regulation of neural precursor cell proliferation), GO:2000179 (positive regulation of neural precursor cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)