Protein: Nuclear factor 1 (A1A5X3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
Subcellular location: Nucleus
Sequence: MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEFREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLYLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAEAGQSDSPNQPSEGDIKDQPENGHLGFQDSFVTSGVFTVSELVRVSQTPIAAGTGPNFSLADLDSSSYYSMSPGAMRRPLPSTSSSSSAKRIKCMEDEVDSPGEESYYPGQGRSPGSGSQASSWHEVEPAGYKLRGSLASSFISRQASPHATPSSLHFPTSPIIQQPGSYFSHHAIRYHPQETLKEFVQLVCPDSGQQAGQVGFLNPNGSSQGKVHNPFLPTPMLPPPPPPPMARPVPLPVPDSKPPSTSTDGGGNSPTSPTYSTPSTSPAQRFVSVGPRDPSFVNIPQQPQWYLG
InterPro domains: - IPR019548: CTF transcription factor/nuclear factor 1, N-terminal (domain) [8-46]
- IPR003619: MAD homology 1, Dwarfin-type (domain) [67-175]
- IPR020604: CTF transcription factor/nuclear factor 1, DNA-binding domain (domain) [1-193]
- IPR000647: CTF transcription factor/nuclear factor 1 (family) [4-474]
- IPR019739: CTF transcription factor/nuclear factor 1, conserved site (conserved_site) [36-47]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0048839 (inner ear development), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048568 (embryonic organ development), GO:0042472 (inner ear morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048562 (embryonic organ morphogenesis), GO:0031326 (regulation of cellular biosynthetic process), GO:0090596 (sensory organ morphogenesis), GO:0007423 (sensory organ development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0042471 (ear morphogenesis), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0043583 (ear development), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)