Protein: Probable cystathionine beta-synthase Rv1077 (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) (P9WP51)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGAGRR
InterPro domains: - IPR005857: Cystathionine beta-synthase (family) [3-458]
- IPR036052: Tryptophan synthase beta chain-like, PALP domain superfamily (homologous_superfamily) [1-317]
- IPR001926: Tryptophan synthase beta chain-like, PALP domain (domain) [7-296]
- IPR046342: CBS domain superfamily (homologous_superfamily) [313-461]
- IPR046353: Cystathionine beta-synthase, C-terminal domain (domain) [334-456]
- IPR000644: CBS domain (domain) [340-458]
- IPR050214: Cysteine synthase/Cystathionine beta-synthase (family) [3-311]
Interaction partners: - Cystathionine gamma-synthase
- O-succinylhomoserine sulfhydrylase
- Serine acetyltransferase
- Serine hydroxymethyltransferase 2
- Phosphoserine phosphatase SerB2
- Serine hydroxymethyltransferase 1
- Adenosylhomocysteinase
- Methionine synthase
- Probable O-acetylhomoserine sulfhydrylase MetC
- 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:1901265 (nucleoside phosphate binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0004124 (cysteine synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044282 (small molecule catabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0006082 (organic acid metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0071496 (cellular response to external stimulus), GO:0006790 (sulfur compound metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0000096 (sulfur amino acid metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0009267 (cellular response to starvation), GO:1901605 (alpha-amino acid metabolic process), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0016054 (organic acid catabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0031667 (response to nutrient levels), GO:0009063 (amino acid catabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0046395 (carboxylic acid catabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019752 (carboxylic acid metabolic process), GO:0006534 (cysteine metabolic process), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009069 (serine family amino acid metabolic process), GO:0009071 (serine family amino acid catabolic process), GO:0045893 (positive regulation of DNA-templated transcription), GO:0009093 (cysteine catabolic process), GO:0006563 (L-serine metabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0009093 (cysteine catabolic process), GO:0006090 (pyruvate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)