Protein: Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] (O55232)
Organism: Rattus norvegicus (Rat)
Function: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. A modulation effect on luteinizing hormone-releasing hormone (LHRH) secretion also suggests a more minor contribution to the regulation of reproductive function.
Subcellular location: Rough endoplasmic reticulum {ECO:0000269|PubMed:9419374}. Cytoplasmic vesicle {ECO:0000269|PubMed:9419374}. Synapse {ECO:0000269|PubMed:9419374}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000269|PubMed:9419374}.
Sequence: MNLPSTKVPWAAVTLLLLLLLPPALLSLGVDAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQANGNHAAGILTMGRRAGAELEPYPCPGRRCPTATATALAPRGGSRV
InterPro domains: - IPR001704: Prepro-orexin (family) [1-130]
Interaction partners: - Pro-MCH
- Orexin/Hypocretin receptor type 1
- Orexin receptor type 2
- Pro-neuropeptide Y
- Leptin
- Pro-opiomelanocortin
- Oxidation resistance protein 1
- Appetite-regulating hormone
- Agouti-related protein
- Protein c-Fos
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0120162 (positive regulation of cold-induced thermogenesis), GO:0120161 (regulation of cold-induced thermogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0044304 (main axon), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0044306 (neuron projection terminus), GO:0099080 (supramolecular complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043025 (neuronal cell body), GO:0005773 (vacuole), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099081 (supramolecular polymer), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0005764 (lysosome), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)