Protein: 26S proteasome regulatory subunit 6B homolog (O74894)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).
Subcellular location: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
Sequence: MNSTEEIDLYNRWKALERQLEMLDLQEGFIKEDCKSLKRELIRAQEEVKRIQSVPLVIGQFLEAIDQNTAIVGSTTGSNYVVRILSTLDRELLKPSASVALQRHSNALVDILPPEADSSISMLRPDERPDVSYADVGGLDVQKQEVREAVELPLTQGDLYRQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTAANFIRVVGSEFVQKYLGEGPRMVRDVFRMARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILIELLTQMDGFDQGANVKVIMATNRADTLDPALLRPGRLDRKIEFPSYRDRRQRRLVFQTITAKMLLSPEVDLDTFIMRPDASSGAQIAAIMQDAGLLAVRKSRGVILQSDIEEAYARAVKPTDMEQFAFYK
InterPro domains: - IPR003960: ATPase, AAA-type, conserved site (conserved_site) [274-292]
- IPR003593: AAA+ ATPase domain (domain) [167-306]
- IPR003959: ATPase, AAA-type, core (domain) [171-303]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [124-376]
- IPR050221: 26S Proteasome Regulatory ATPase (family) [14-378]
- IPR032501: Proteasomal ATPase, second OB domain (domain) [58-113]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [13-123]
Interaction partners: - Probable 26S proteasome subunit rpt4
- 26S proteasome regulatory subunit 7 homolog
- 26S proteasome regulatory subunit 8 homolog
- 26S proteasome regulatory subunit rpn11
- 26S proteasome regulatory subunit 6A
- 26S proteasome regulatory subunit rpn8
- 26S proteasome regulatory subunit rpn7
- 26S proteasome regulatory subunit 4 homolog
- 26S proteasome regulatory subunit rpn2
- 26S proteasome regulatory subunit rpn1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0022624 (proteasome accessory complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0008540 (proteasome regulatory particle, base subcomplex), GO:0005838 (proteasome regulatory particle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)