Protein: protein-tyrosine-phosphatase (EC 3.1.3.48) (Q9V3V3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell junction {ECO:0000256|ARBA:ARBA00004282}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MPLKFLKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGRQYFPWKEFHTVTIDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRYIDTATPSSLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPDDGNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTRLI
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [960-1252]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1155-1236]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [112-222]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [24-108]
- IPR018979: FERM, N-terminal (domain) [27-92]
- IPR000299: FERM domain (domain) [20-318]
- IPR041782: PTPN14/21, FERM domain C-lobe (domain) [225-317]
- IPR019749: Band 4.1 domain (domain) [16-230]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [106-223]
- IPR018980: FERM, C-terminal PH-like domain (domain) [234-322]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1133-1244]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1184-1194]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [982-1247]
- IPR019748: FERM central domain (domain) [113-230]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [225-317]
Interaction partners: - Protein kibra
- Transcriptional coactivator yorkie
- 6-pyruvoyl tetrahydrobiopterin synthase
- Myopic
- Dizzy isoform AII
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0044238 (primary metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032989 (cellular component morphogenesis), GO:0009266 (response to temperature stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0010646 (regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0030030 (cell projection organization), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0097696 (receptor signaling pathway via STAT), GO:0006796 (phosphate-containing compound metabolic process), GO:0048666 (neuron development), GO:0036211 (protein modification process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:1901184 (regulation of ERBB signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0016311 (dephosphorylation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006470 (protein dephosphorylation), GO:0007424 (open tracheal system development), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway), GO:0035335 (peptidyl-tyrosine dephosphorylation), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0008045 (motor neuron axon guidance), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)