Protein: Probable E3 ubiquitin-protein ligase MARCHF10 (EC 2.3.2.27) (Membrane-associated RING finger protein 10) (Membrane-associated RING-CH protein X) (MARCH-X) (RING finger protein 190) (RING-type E3 ubiquitin transferase MARCHF10) (Q8NA82)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Sequence: MLHDARDRQKFFSDVQYLRDMQHKVDSEYQACLRRQEYRRDPNEKKRDQFWGQETSFERSRFSSRSSSKQSSSEEDALTEPRSSIKISAFKCDSKLPAIDQTSVKQKHKSTMTVRKAEKVDPSEPSPADQAPMVLLRKRKPNLRRFTVSPESHSPRASGDRSRQKQQWPAKVPVPRGADQVVQQEGLMCNTKLKRPNQERRNLVPSSQPMTENAPDRAKKGDPSAPSQSELHPALSQAFQGKNSPQVLSEFSGPPLTPTTVGGPRKASFRFRDEDFYSILSLNSRRESDDTEEETQSEECLWVGVRSPCSPSHHKRSRFGGTSTPQAKNKNFEENAENCRGHSSRRSEPSHGSLRISNAMEPATERPSAGQRLSQDPGLPDRESATEKDRGGSENAKKSPLSWDTKSEPRQEVGVNAENVWSDCISVEHRPGTHDSEGYWKDYLNSSQNSLDYFISGRPISPRSSVNSSYNPPASFMHSALRDDIPVDLSMSSTSVHSSDSEGNSGFHVCQPLSPIRNRTPFASAENHNYFPVNSAHEFAVREAEDTTLTSQPQGAPLYTDLLLNPQGNLSLVDSSSSSPSRMNSEGHLHVSGSLQENTPFTFFAVSHFPNQNDNGSRMAASGFTDEKETSKIKADPEKLKKLQESLLEEDSEEEGDLCRICQIAGGSPSNPLLEPCGCVGSLQFVHQECLKKWLKVKITSGADLGAVKTCEMCKQGLLVDLGDFNMIEFYQKHQQSQAQNELMNSGLYLVLLLHLYEQRFAELMRLNHNQVERERLSRNYPQPRTEENENSELGDGNEGSISQSQVV
InterPro domains: - IPR052297: RING-CH-type E3 ubiquitin-protein ligase (family) [1-805]
- IPR011016: Zinc finger, RING-CH-type (domain) [651-721]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [644-722]
- IPR042583: MARCH10, RING-CH finger, C4HC3-type (domain) [650-725]
Interaction partners: - E3 ubiquitin-protein ligase MARCHF11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0060548 (negative regulation of cell death), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0031647 (regulation of protein stability), GO:0043170 (macromolecule metabolic process), GO:0009894 (regulation of catabolic process), GO:2001021 (negative regulation of response to DNA damage stimulus), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0042177 (negative regulation of protein catabolic process), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0051248 (negative regulation of protein metabolic process), GO:0043518 (negative regulation of DNA damage response, signal transduction by p53 class mediator), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:2001233 (regulation of apoptotic signaling pathway), GO:2001020 (regulation of response to DNA damage stimulus), GO:1902230 (negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0051247 (positive regulation of protein metabolic process), GO:0050821 (protein stabilization), GO:1902531 (regulation of intracellular signal transduction), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0042981 (regulation of apoptotic process), GO:1901796 (regulation of signal transduction by p53 class mediator), GO:0030162 (regulation of proteolysis), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:1901799 (negative regulation of proteasomal protein catabolic process), GO:0043066 (negative regulation of apoptotic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway), GO:1901797 (negative regulation of signal transduction by p53 class mediator), GO:1902229 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage), GO:0043516 (regulation of DNA damage response, signal transduction by p53 class mediator), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0045861 (negative regulation of proteolysis), GO:0031401 (positive regulation of protein modification process), GO:1902253 (regulation of intrinsic apoptotic signaling pathway by p53 class mediator), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903321 (negative regulation of protein modification by small protein conjugation or removal), GO:1902165 (regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator), GO:1902254 (negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator), GO:1903051 (negative regulation of proteolysis involved in protein catabolic process), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0032446 (protein modification by small protein conjugation), GO:0031396 (regulation of protein ubiquitination), GO:0016567 (protein ubiquitination), GO:0031397 (negative regulation of protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination), GO:0006513 (protein monoubiquitination), GO:1902916 (positive regulation of protein polyubiquitination), GO:1902914 (regulation of protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)