Protein: Mitochondrial Rho GTPase 1 (Q5ABR2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein
Sequence: MSPDAIRVVVCGDDAVGKSSLITSLIKETIIEPQTNNVLPPITISRNDYIESSQEYLNDQDHHHHHQSSPSTMKNKRKHNNKRERERERESSINNVQPNEISEYIPNITTIIDTSSSDMTNLQKELKRADVIWLVYSDHYTYERISLHWMPLFRSMGVNLPIILCANKSDLFPKSKSNLKSTNSDEFVPLINEFKEIEAGVRCSAKNNYNVVEAFYLCQRAVTHPISPIFDAKEGNLKPGAIKPLKRIFWLSDTDQDGYLNFEELSELHKKCFGIEASKSDYEEIVNLIDQKILPSYNTTIETQTPPQQQHLATSAGTPNGTTTTTSKGISEDGFILLNKIYAESGRHETVWCILRAYHYTNSLSLSDKFLYPRLDVNPHSSVELSPTGYKFFVDLFIKFDKDNDGGLNEDELNTLFRSTPGIPKLWVESNFPSSIVCNEEGYVTLQGWLAQWNLTTFLSYKTTLEYLAYLGFDEGNSTKALKVTKPRKIRQKNGKTYRNAVNDRNVFNCFIVGAPKAGKSSLLESFLHGSYSDIYSPTIQPRLVVKDIELRGGKQCYLILEELGELEPAILENKSRLDQCDVICYAYDSSDPESFQYLVELREKHGHLLDEVPAVFVALKADLDKQQQRCDVQPENYTRDLFLNSPLHVSLAWNSSLHEMFIQLVDAAKTPSSATPGIELEVSVDQDDIKHIIMTGAAIAVVGLVSIWVLNSLRR
InterPro domains: - IPR013567: EF hand associated, type-2 (domain) [323-389]
- IPR001806: Small GTPase (family) [8-667]
- IPR052266: Mitochondrial Rho GTPase/EF-hand domain-containing protein (family) [193-597]
- IPR013566: Mitochondrial Rho GTPase 1/3, EF hand associated, type-1 (domain) [427-496]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4-673]
- IPR011992: EF-hand domain pair (homologous_superfamily) [220-456]
- IPR021181: Mitochondrial Rho GTPase (family) [4-709]
- IPR020860: MIRO domain (domain) [3-671]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [253-265]
- IPR002048: EF-hand domain (domain) [240-423]
Interaction partners: - Mitochondrial distribution and morphology protein 12
- Mitochondrial distribution and morphology protein 10
- Rga2p
- Mitofusin
- Mitochondrial import receptor subunit TOM20
- Mitochondrial distribution and morphology protein 34
- Mitochondrial outer membrane protein porin
- SAM complex subunit
- Maintenance of mitochondrial morphology protein 1
- Tom22p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0022406 (membrane docking), GO:0048878 (chemical homeostasis), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0051640 (organelle localization), GO:0140056 (organelle localization by membrane tethering), GO:0016043 (cellular component organization), GO:0055088 (lipid homeostasis), GO:0006810 (transport), GO:0051128 (regulation of cellular component organization), GO:0051646 (mitochondrion localization), GO:0055091 (phospholipid homeostasis), GO:0071702 (organic substance transport), GO:0048311 (mitochondrion distribution), GO:0033043 (regulation of organelle organization), GO:0071705 (nitrogen compound transport), GO:1990456 (mitochondrion-endoplasmic reticulum membrane tethering), GO:0006996 (organelle organization), GO:0006811 (monoatomic ion transport), GO:0015886 (heme transport), GO:0007005 (mitochondrion organization), GO:0006812 (monoatomic cation transport), GO:0048308 (organelle inheritance), GO:0000001 (mitochondrion inheritance), GO:0010821 (regulation of mitochondrion organization), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport), GO:1901678 (iron coordination entity transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)