Protein: Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R) (P30551)
Organism: Rattus norvegicus (Rat)
Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
InterPro domains: - IPR015276: Cholecystokinin A receptor, N-terminal (domain) [16-62]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [58-401]
- IPR036472: Cholecystokinin A receptor, N-terminal domain superfamily (homologous_superfamily) [16-58]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [73-386]
- IPR009126: Cholecystokinin receptor (family) [109-438]
- IPR000596: Cholecystokinin receptor type A (family) [35-430]
Interaction partners: - Cholecystokinin
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Gastrin
- Gastrin/cholecystokinin type B receptor
- Guanine nucleotide-binding protein subunit alpha
- C-C motif chemokine
- Guanine nucleotide-binding protein G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042562 (hormone binding), GO:0017046 (peptide hormone binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0007586 (digestion), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0042698 (ovulation cycle), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:1903530 (regulation of secretion by cell), GO:0012501 (programmed cell death), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0035556 (intracellular signal transduction), GO:0046887 (positive regulation of hormone secretion), GO:0080134 (regulation of response to stress), GO:0044057 (regulation of system process), GO:0006952 (defense response), GO:0002209 (behavioral defense response), GO:1901700 (response to oxygen-containing compound), GO:0044849 (estrous cycle), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0046883 (regulation of hormone secretion), GO:0042127 (regulation of cell population proliferation), GO:1901698 (response to nitrogen compound), GO:0050806 (positive regulation of synaptic transmission), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0010647 (positive regulation of cell communication), GO:0031349 (positive regulation of defense response), GO:0099177 (regulation of trans-synaptic signaling), GO:0048520 (positive regulation of behavior), GO:0050795 (regulation of behavior), GO:0008284 (positive regulation of cell population proliferation), GO:1903532 (positive regulation of secretion by cell), GO:1901652 (response to peptide), GO:0031347 (regulation of defense response), GO:0071705 (nitrogen compound transport), GO:0000165 (MAPK cascade), GO:0002793 (positive regulation of peptide secretion), GO:0050804 (modulation of chemical synaptic transmission), GO:0051968 (positive regulation of synaptic transmission, glutamatergic), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0032230 (positive regulation of synaptic transmission, GABAergic), GO:0043434 (response to peptide hormone), GO:0090276 (regulation of peptide hormone secretion), GO:0010243 (response to organonitrogen compound), GO:0090087 (regulation of peptide transport), GO:0031644 (regulation of nervous system process), GO:0006915 (apoptotic process), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0051931 (regulation of sensory perception), GO:0001821 (histamine secretion), GO:0032868 (response to insulin), GO:0032228 (regulation of synaptic transmission, GABAergic), GO:0070371 (ERK1 and ERK2 cascade), GO:0002791 (regulation of peptide secretion), GO:0051966 (regulation of synaptic transmission, glutamatergic), GO:0051608 (histamine transport), GO:0051930 (regulation of sensory perception of pain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0044306 (neuron projection terminus), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0097447 (dendritic tree), GO:0043195 (terminal bouton), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0044305 (calyx of Held), GO:0030424 (axon), GO:0044309 (neuron spine)