Protein: Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog) (Tetratricopeptide repeat-containing hedgehog modulator 1) (Q0HA38)
Organism: Mus musculus (Mouse)
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs (By similarity). Negatively modulates the SHH signal transduction.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:18327258}. Note=In polarized epithelial inner medullary collecting ducts cells and in the nodes of mice at 8.0 dpc, colocalizes with alpha-tubulin in cilia. Expressed in a punctate manner throughout the axoneme from the cilia base to the tip.
Sequence: MDSQGLKTLINYYCQERYYHHVLLVASEGMKKYSSDPVFRFYHAYGTLMEGKAQEALREFEAIKNKQDVSLCSLMALMYVHKMSPNPDREAILELDTKMKEQRKEAGRKALYHAGLFLWHIGRHDKAREYIDRMSKMPHDSNEGPILKAWLDITRGKEPYAKKALRYFEEGLQDGNDIFALLGKVLCLEIRQNYSGALETVSQIIVNFPSFLPAFEKKMKLQLALQDWDQTVETAQRLLLQDNHNVEALRMLALYYLCREGDVEKAATKLENLGNALDVMEPQNAQLFYKITLAFSRTCGRNQLILQKVQSFLEKAFSLTPQQAEIATELGYQMILQGKVKEAWKWYRTAMTLNESNISAVTGLIRCQLIEGQLQDADQQLEFFSEFQQSMGKSAELMYLHAVLATKKNNRQDEVINLLNDVVNTHFSHLEDLPLGIQYFEKLNPDFLLEVVTEYLNLCPIQPAGPGQPLSPVLRRCSSVLETIIRSVPGLPQAVFLMAKVKYLSGDTEAAYNNLQHCLEHSPSYAEAHLLMAQVYLSQDKVKLCSQSLELCLSYNFNVREYPLYHLIKAQSQKKMGEVAEAIKTLHMAMNLPGMRRSRASSKSKHRTEVDASHRLSIFLELVEVHRLNGEQHEAAKVLQDAIHEFSGTCEELRVTIANADLALAQGDTDRALSMLRNVTTEQPYFIEAKEKMADIYLKHRKEKMLYITCYREIAERMPSPRSFLLLGDAYMNIQEPEEAIVAYEQALNQNPKDGTLARKIGKALVKTHNYSKAITYYEAALKSGQQNCLCYDLAELLLRLKLYEKAEKVLQHSLAHEPVSELSALMVDGRSQVLLAKVYSKMERPSDAIAALQQARELQARILKRVQMEQPDAVPSQKHFAAEICAEIAKHSAAQRDYEKAITFYREALVHCETDSKIMLELAQLYLAQEDLDASLRHCALLLQRDQDNEPATMLMADLMFRKQDYEQAVYHLQQLLDRKPDNFMTLSRLIDLLRRCGKLEDVPRFFLMAEKHNSRTKLEPGFQYCKGLHFWYTGEPNDALRHFNKARKDSDWGQNALYNMIEICLNPDNETIGGEVFENLNGDLGTSPEKQESVQLAVRTAEKLLKELKPQTVQGRLQLRIMENCCLMATKQKSSVEQALNTFTEIAASEKDHIPALLGMATAYMILKQTPKARNQLKRIAKMPWNPIEAEDLEKSWLLLADIYIQSAKYDMAEELLKRCLCHNRSCCKAYEYMGYIMEKEQAYTDAAFNYEMAWKHSNQTNPAVGYKLAFNYLKAKRYVDAIDVCHQVLEAHPTYPKIRKDILDKARASLRP
InterPro domains: - IPR040364: Tetratricopeptide repeat protein 21A/21B (family) [8-1315]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [2-1314]
- IPR056836: Tetratricopeptide repeat protein 21A/21B, fourth ARM domain (domain) [757-910]
- IPR056835: Tetratricopeptide repeat protein 21A/21B, fifth ARM repeats domain (domain) [951-1067]
- IPR056832: Tetratricopeptide repeat protein 21A/21B, second ARM domain (domain) [269-540]
- IPR056834: Tetratricopeptide repeat protein 21A/21B, C-terminal ARM domain (domain) [1102-1310]
- IPR019734: Tetratricopeptide repeat (repeat) [108-1298]
- IPR056833: Tetratricopeptide repeat protein 21A/21B, N-terminal ARM repeat (domain) [10-232]
Interaction partners: - Intraflagellar transport protein 43 homolog
- Intraflagellar transport protein 122 homolog
- WD repeat-containing protein 19
- Intraflagellar transport protein 140 homolog
- WD repeat-containing protein 35
- Intraflagellar transport protein 81 homolog
- Intraflagellar transport protein 74 homolog
- Intraflagellar transport protein 88 homolog
- Intraflagellar transport protein 57 homolog
- Intraflagellar transport protein 80 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007018 (microtubule-based movement), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0030317 (flagellated sperm motility), GO:0007283 (spermatogenesis), GO:0003341 (cilium movement), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0060294 (cilium movement involved in cell motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0030990 (intraciliary transport particle), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097542 (ciliary tip), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)