Protein: Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8) (P41220)
Organism: Homo sapiens (Human)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:28784619}. Cytoplasm {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17901199}. Cytoplasm {ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:17901199}. Cytoplasm {ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:17901199}. Mitochondrion {ECO:0000269|PubMed:17901199}.
Sequence: MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
InterPro domains: - IPR044926: RGS, subdomain 2 (homologous_superfamily) [105-184]
- IPR034947: Regulator of G-protein signalling 2, regulator of G protein signaling domain (domain) [84-197]
- IPR016137: RGS domain (domain) [80-199]
- IPR024066: RGS, subdomain 1/3 (homologous_superfamily) [78-198]
- IPR036305: RGS domain superfamily (homologous_superfamily) [72-200]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- cGMP-dependent protein kinase 1
- Adenylate cyclase type 3
- cGMP-dependent protein kinase 2
- Neurabin-2
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit beta-5
- Glycerophosphodiester phosphodiesterase 1
- Guanine nucleotide-binding protein subunit alpha-14
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006955 (immune response), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0050794 (regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0043085 (positive regulation of catalytic activity), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0051336 (regulation of hydrolase activity), GO:0043087 (regulation of GTPase activity), GO:0051345 (positive regulation of hydrolase activity), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0043547 (positive regulation of GTPase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0019898 (extrinsic component of membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0019897 (extrinsic component of plasma membrane), GO:0098562 (cytoplasmic side of membrane), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)