wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Pickpocket 23 short form (Q86LG2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MPQEKRHPPESRTQRFLETLVIFRRSLIYQTKEFFQNSTLHGVRYIAESGRPIGEKFMWFCFTSIGAVTALVIIMSLWEKFQTNPTITGLDTDFHNQNVVFPTTVVCPEAAFDHDKTYEKVYNTLANYDEAQAQMYTPFLRILTSLNFENVRDAKVLSQSIPQNLLDAHTIREWAFEGHIDCKNVFVSCKYRDEDIPCCDHFEPIYTEHGFCYAFNSRFKSTPTEDVKTGAPHDLYETDKKWALFFIPNSTSRIFIFSNEEYFGSDFNAQIDWSEPQLVEVRISKKNTYTTDDARQLSIGQRKCIFSDEVKLNYFPDAYTFSSCMKQCRMNKAIKLCKCNPPFYKPINVPMCSIKDFDCLDEFKSNITNIKDCLQCELSCSKTVFNIDKLIKMSDRPESLGVLVEFLTWPIIRYKREVLFGWVDLLVSFGGIASLFLGFSLLSGVEIIYYFTLRACCMVYKNRVNYANRIFQSTSI
InterPro domains: - IPR001873: Epithelial sodium channel (family) [28-462]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015280 (ligand-gated sodium channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0042221 (response to chemical), GO:0019098 (reproductive behavior), GO:0007610 (behavior), GO:0007617 (mating behavior), GO:0010033 (response to organic substance), GO:0060179 (male mating behavior), GO:0019236 (response to pheromone), GO:0007619 (courtship behavior), GO:0008049 (male courtship behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: VRK serine/threonine kinase 3 (M0QYA8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MISFCPDCGKSIQAAFKFCPYCGNSLPVEEHVGSQTFVNPHVSSFQGSKRGLNSSFETSPKKVKWSSTVTSPRLSLFSDGDSSESEDTLSSSERSKGSGSRPPTPKSSPQKTRKSPQVTRGSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQGILYEAAPTSTLTCDSGPQKQKFSLKLDAKDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [197-404]
- IPR026870: Zinc-ribbon domain (domain) [4-26]
- IPR050235: Casein Kinase 1 Ser/Thr Protein Kinase (family) [177-405]
- IPR000719: Protein kinase domain (domain) [166-406]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019902 (phosphatase binding), GO:0019903 (protein phosphatase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0061061 (muscle structure development), GO:0048513 (animal organ development), GO:0007517 (muscle organ development), GO:0060537 (muscle tissue development), GO:0007519 (skeletal muscle tissue development), GO:0060538 (skeletal muscle organ development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Serine carboxypeptidase ctsa-3.1 (EC 3.4.16.-) (P52716)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MCRTLLGVAFLVVTVLSQGEKDLIQNLPGLLFKANFKSYSGYVDANANGTWKMHYMLTESRSNPDTDPLLVWFNGGPGCSSLGGLFEELGPFYVNFDGQTLYENPYAWNAKANVLYLESPIGVGYSYDTTTPGYFQANDDQSAAQNYQALTNFFNVAQPKYTNRTFYLSGESYAGIYIPMLTDLIVQGINNPNQPFPNKNFQGSAIGNGFMNVAGLLNALTLWSAYHGRVSEQNWADIKANCSKGADVDSFDFSQFTTSQNKIDYVGDGSYCGNLIQPLISQNALGNEGFDQYNFYQECYDKSVFQAPPPAGGKRHKRSAMQGVSSVQKNLQYQQLGNFQGTSNLAKNTATLVNRFSNDNQFGYFCWNEDAVSKYLNSDNVQNALNIPQAWKDQKNTWEDCRMSIYNNYTLKYNTTNRFFNNIITNLTTDFRFLIYNGDVDTVCNYLGDAKHILQVAKDNGLTSGPRTPWYYSNNQQLAGYVQTYSGKNKNNAMITIDLLTVKGAGHMVPYDRAGPSVQMISNFVWAPKNVVINYTSQDNFNPNIQLSDLVDSGSSSTVAFFISMFAVLLNIVF
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [17-525]
- IPR033124: Serine carboxypeptidases, histidine active site (active_site) [497-514]
- IPR001563: Peptidase S10, serine carboxypeptidase (family) [26-525]
- IPR018202: Serine carboxypeptidase, serine active site (active_site) [168-175]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0008238 (exopeptidase activity), GO:0070008 (serine-type exopeptidase activity), GO:0004180 (carboxypeptidase activity), GO:0004185 (serine-type carboxypeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)
Protein: Hym1p (Q5AHK0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MAFLFKRNPKTPPELVRALNDQVSKLDYASPDNAKKYQDECARYLKNMKVILHGDDEVEPQPDQITQLAQEIYSTDCLYYLVVNLRKLDFDSRKDVVILFSTLLRRTMANKSPTVDYLVHSKPEIITMLIKGPENLEIGLICGQILRDCIKFEVINRFVLYSPSFYNFFKYVQIPTFEIATDAMMTLHELLTTHRKLVSEFLGNNYDVFITAINKLITSKNYVTKRQSVKLLNELVSQRSNQQFLSKFFDDANNLKLTMLLLSDKSKNLQLEGFHTLKFFVANPKRSQKVTDILIKNKANFIEFFKTFDIASFHDSNIIEERDYTLGEIKNLPDRIH
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [10-336]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1-332]
- IPR013878: Mo25-like (family) [1-333]
Interaction partners: - non-specific serine/threonine protein kinase
- Sog2p
- CBK1 kinase activator protein MOB2
- Serine/threonine-protein kinase CBK1
- Cas4p
- non-specific serine/threonine protein kinase
- non-specific serine/threonine protein kinase
- Sec63 complex subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Cys-Gly metallodipeptidase dug1 (EC 3.4.13.-) (GSH degradosomal complex subunit DUG1) (Q9P6I2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Has a Gly-Cys dipeptidase activity.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Sequence: MKMSLDKLYEVIDKKKDEFVTRLSRAVSIPSVSADVTLRPKVVEMADFVVSEFTKLGAKMEKRDIGYHQMDGQDVPLPPIVLGQYGNDPSKKTVLIYNHFDVQPASLEDGWSTDPFTLTVDNKGRMFGRGATDDKGPLIGWISAIEAHKELGIDFPVNLLMCFEGMEEYGSEGLEDLIRAEAEKYFAKADCVCISDTYWLGTKKPVLTYGLRGVCYFNITVEGPSADLHSGVFGGTVHEPMTDLVAIMSTLVKPNGEILIPGIMDQVAELTPTEDSIYDGIDYTMEDLKEAVGADISIYPDPKRTLQHRWRYPTLSLHGIEGAFSGSGAKTVIPAKVIGKFSIRTVPNMESETVERLVKEHVTKVFNSLNSKNKLAFNNMHSGSWWISSPDHWHYDVGKKATERVYGITPDFVREGGSIPVTVTFEQSLKKNVLLLPMGRGDDGAHSINEKLDLDNFLKGIKLFCTYVHELASVSP
InterPro domains: - IPR002933: Peptidase M20 (family) [95-469]
- IPR011650: Peptidase M20, dimerisation domain (domain) [209-365]
- IPR051458: Cytosolic and Metallo Dipeptidase (family) [4-471]
- IPR001261: ArgE/DapE/ACY1/CPG2/YscS, conserved site (conserved_site) [131-170]
- IPR017153: Cytosolic nonspecific dipeptidase/DUG1 (family) [1-476]
Interaction partners: - Putative aminopeptidase C13A11.05
- Glutathione hydrolase proenzyme 1
- Glutathione synthetase large chain
- Glutamate--cysteine ligase
- Putative glutamate--cysteine ligase regulatory subunit
- Glutathione hydrolase proenzyme 2
- Glutathione-specific gamma-glutamylcyclotransferase
- Uncharacterized protein C11D3.14c
- Protein arg11
- Homocysteine synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0042802 (identical protein binding), GO:0008237 (metallopeptidase activity), GO:0008242 (omega peptidase activity), GO:0008238 (exopeptidase activity), GO:0016805 (dipeptidase activity), GO:0008235 (metalloexopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:1901575 (organic substance catabolic process), GO:0006749 (glutathione metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Copper transporter 2 (OsCOPT2) (Q60EN8)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the transport of copper, in cooperation with SWEET11 and COPT1. Contributes to the removal of copper (Cu) from xylem, and thus to the sensitivity toward bacterial pathogens such as X.oryzae pv. oryzae (Xoo).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20852017}; Multi-pass membrane protein {ECO:0000269|PubMed:20852017}.
Sequence: MDMGGNGMAMPPPPAPVKKARYMHMTFFWGKNTEVLFTLWPGARGGMYALAILFMFALAVLLEFRGYRVLEARLARRRAPRAAAALRTAVHAVRVGVAYLIMLALMSFNGGVFLAIVAGHAAGFLAFRAGLCGGGPAPPLEEDRKNDPVCC
InterPro domains: - IPR007274: Ctr copper transporter (family) [20-132]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005375 (copper ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0035434 (copper ion transmembrane transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006825 (copper ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: C2H2-type domain-containing protein (I2HAK0)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MGEFQYNFDDEDTVLIGNYEEVGTEIDEADEQHNEENSEDDEEDESPIPSKKRVSFAVPLVQSRSKQKDEMNKVHIIKCHFDKCNKSYNWRKKYGKLRLVDHAFTHVPHLKMKCNFCDYMCKGIRNIRLHHKKSHPDEQLTGFGIKSVVRTSKKGKDLAKVWDECFKKNRVLQHGSGTDSNLLHFSRQDKGSKRSQKSMDSGAKQKLDEARDEDVKPFYFFRIR
InterPro domains: - IPR053360: Putative zinc finger domain-containing protein (family) [2-214]
- IPR013087: Zinc finger C2H2-type (domain) [114-135]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0016070 (RNA metabolic process), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)
Protein: M-zodatoxin-Lt8g (M-ZDTX-Lt8g) (Cytoinsectotoxin-1g) (CIT-1g) (P85259)
Organism: Lachesana tarabaevi (Spider)
Function: Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S.carnaria. Has antibacterial activity against the Gram-negative bacteria E.coli. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Subcellular location: Secreted {ECO:0000269|PubMed:18215128, ECO:0000269|PubMed:27287558}.
Sequence: MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYVLKHYGKKALQKASEKL
InterPro domains: - IPR018802: Latarcin precursor (family) [34-71]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0051702 (biological process involved in interaction with symbiont), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0051873 (killing by host of symbiont cells), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0051838 (cytolysis by host of symbiont cells), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Uncharacterized FAD-binding protein C1783.01 (Q9US28)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000269|PubMed:16823372}.
Sequence: MISHVLVKDTSCLKVRTSYKCFVKYFPKCSVQSSFHSYDELAFSRRLYNLPRTLLNSRYYSNHSHGLVHGSKSPPSSQFLVPSFLQFNGQLKALCNNSAFQALPIKLSDLQKHWPSLKPHPLPPKRVSLGIPSISNPPVDTVISDSPTSPHPPSFVQPHPPYGIFAAPILDVRVLTNPGAVKRTYNLCLDISKYPLLEGKDWKIGGSFGIMPPNSDAEVLHLAHLLKIPQHELYVTKVLRTNGGRWPTIWGEDKPRCLYTSLYHIFKWCSDFISKPPTKSLIRLLAEHTLNPVEKSVLLALSDFRQDESYCRICTQSCVTLPDILEAFPSCHPPVDHLISALPQLMPRWYSISNDPSLANKRLEMAFTVQEYHSPNGQSRTGICTGFLEDLALAFLKARHDGSLANKKFTVPMFRGVQQNPFAKEFHNDGPMCLIGAGVGIAPFRGFVQRRLANAACTGKVWIIQGCRDQKLDELYHGEWNTVPGHHKNPKCRAKKLVVESRNGRREYVQDAVRRHGDVIWDVLSHKNGRIYLCGSGNSFVSEIEKALMDVAMKYGKLSKEEAQKELKNWQKPMNCKLIKEVW
InterPro domains: - IPR023173: NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily (homologous_superfamily) [163-346]
- IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [144-392]
- IPR001433: Oxidoreductase FAD/NAD(P)-binding (domain) [434-536]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [162-424]
- IPR001709: Flavoprotein pyridine nucleotide cytochrome reductase (domain) [202-538]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [422-583]
- IPR003097: Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding (domain) [164-387]
Interaction partners: - Sulfite reductase subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016722 (oxidoreductase activity, acting on metal ions)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0000103 (sulfate assimilation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Chaperone protein DNAJ, putative (Q57VS0)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSSGLTARRLILQQLTAVTQHIPLQARRTSGKGWWLSSFVRPEGDRRVFTLITEEEVAFLKRRCEEEGDEGRVILSTRPTRNIVRAVGGAALNITLSFLVSPLLALSVSLEAIRLRGLRPAALVIAPGVGLFWGAVFMAIAWYAAVQQMLLCGVHTLRAPIFYLFCPGCCWNELSCRYEYPSGVVGNSHPLLSLQAPPEKLFERAMKRETRRKRRGKRDVGYERKGGTHPSEGDDYYAILGVTRDATPQQIKEAYNRLALEIHPDRNPSQSAASQFDVLTKAYRVLGNAEKRRKYDMGGRSGVEDIGKKKRGAVRALFGGDALYAIVGDVKTGSFSQRVIDGLDWTQEELAIFRQRTLERCRDELLSVYLQPLRSEKDSKGAPALQELKGRLQRLLNTGLAREVLHAVGHEYMRVVLYGKASGPRERMTLYLNEAGPHRMRRRLDKWRHLCRIRQHTLRDSATMVDLAWYTSVEELESTARWVATSLLLDHQVPEEERRQRLEALQALAEIFITYGQSYKGANKQTMDALMNSLRDYYQQQKRGEGG
InterPro domains: - IPR001623: DnaJ domain (domain) [234-310]
- IPR052423: Erythrocyte Membrane Invagination Regulator (family) [235-415]
- IPR026894: DNAJ-containing protein, X-domain (domain) [463-524]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [221-321]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0031072 (heat shock protein binding), GO:0030544 (Hsp70 protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)