Protein: Alpha-ketoglutarate-dependent dioxygenase FTO (A0A8M9PKY4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Nucleus speckle
Sequence: MKPRQRKQYFRNMKRSDDSEREKRRKRRRLLQELGEQRIPYLSPTDPGFQDLWDSSYAGLALRQSGTLPEGLHEKVQSALLTLQRHGCLLRDLVRVRDRDVFTAVSRALVGQPGYTYRYLDTRLFTIPWHCEGEEGQKDEKGKPCCDSDLRDACKALWELNQFFCSDVKQQTNARGVKRTRSDTENSEDAPGEGMCEEESVKDRLVEEKTIEEEEEDSGQGCSHSSPPSSTPPAAQASLVQFNVTLINYMNPAAMTQLKEEPYYGMGKMAVGWHHDENLVPLSPVAVYSYSCPAEPKNEGVTEKDGEGKSKEKEREAKGEGTSTEEVKKEGEASVKEDVEKEKTCWRVGLKVAWDIHTPGLALPLQSGDCYYMTDDLNRTHQHCVLAGDTARFSSTHRVAQCCTGTLDYIQKRCSEALENLHSDPEKNAKSLISLLPSILQRIEDIHNEVEFEWLRQYWFQGRRYARFCSWWTKPMEQMEKDWKEMERMTQLLLVVVEDEATAQENRREMADVLLNALTDRQQHRQTWRDRCQSSLAQTLPPEEAPVDRPYWSNDDPDMPLPFDLSDIINRVESLLWRCV
InterPro domains: - IPR037151: Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily (homologous_superfamily) [41-406]
- IPR024367: Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain (domain) [46-402]
- IPR032868: Alpha-ketoglutarate-dependent dioxygenase FTO (family) [2-577]
- IPR038413: FTO, C-terminal domain superfamily (homologous_superfamily) [407-540]
- IPR024366: Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal (domain) [405-573]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0032451 (demethylase activity), GO:0016491 (oxidoreductase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0043167 (ion binding), GO:0140098 (catalytic activity, acting on RNA), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0043169 (cation binding), GO:0140097 (catalytic activity, acting on DNA), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0008198 (ferrous iron binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0043414 (macromolecule methylation), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0060284 (regulation of cell development), GO:0051147 (regulation of muscle cell differentiation), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:0051153 (regulation of striated muscle cell differentiation), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:0018205 (peptidyl-lysine modification), GO:0010830 (regulation of myotube differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)