Protein: Fatty acid synthase subunit alpha (B6K892)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Sequence: MRPEVEQELAHTLLLELLAYQFASPVRWIETQDVLLSPPYSSERLVEIGPSPTLAGMAQRTLKMKYENIDAALSMNREVLCYSRDKKNIYYNIENEEPQEVAPEPVAAAAPTPAAAAPAAPAAAPAPAASEPVAAAAELPDELPKAVDVLHILVAQKLKKTVDEVSPQKAIKDLVGGKSTLQNEILGDLQKEFGSTPEKPEETPLDELGATMQTSFSGQLGKQSSSLISRMISSKMPGGFSNSAVRAYLKNRFGLATGRTNSVLLLGLTMEPAARIGSEAEAKAWLDTVAQKYASRNGITLSAPAAASSSGGGQAAVIDEATFKKLTQSNTKLVTQQLELFANYLNKDLRAGDKAAVAERAVSDALRAQLDLWNNEHGEFYASGISPIFSPLKARVYDSEWNWARQDALKMFYDIIFGRLKLVDREIVSRCIAVMNRANPVLLEFMQYHIDHCPSDKGATYQLAKELGQQLIDNCKEAIEKPPVFKDVNYPTAPSTEIDERGNLNYEEVPRSGVRKLEQYVAEMARGGKVPPASKSKAKVQDDLARIYRIITSQNKMTRSSKLQVKQLYAQVLRNLNIRLPSGNDKTPAKETIPFLHLCRKSGEAWEFNKTLTAAYLDVLENGAKNGITFHGKCALVTGAGAGSIGVQIVKGLLAGGARVIVTTSRYSRKVTEFYQSLFTRYGSRGSSLIVVPFNQASKQDVEALVKYIFDEKDGLGWNLDYIVPFAAIPENGREIDNIDSRSELAHRIMLTNVMRLLGAVKVEKAARGFDTRPAQVILPLSPNHGTFGNDGMYSESKLALEALFNRWSSESWSNYLLICGAVIGWTRGTGLMAPNNIVAQGIEKYGVRTFSQAEMAFNILGLMSQKIVNICQTEPVYANLNGGLELLPSIKDLSTRLRTELIQTAEIRKAVAAEAAFDHNVLNGPGSDAIYHKTAIQPRANLKFEFPKAKPYEAYAHLSHLRGMVDLERVAVVTGFSEVGPWGNSRTRWDMECFGEFSLEGCVELAWIMGLIKNFNGTLKNGKPYSGWVDAKTGEPVDDKDVKSKYESYMIEHCGIRIVESDMFNDYHPEKKELLQEVVIDHDLEPFEASKDAAHEFKLKHGDKVEIFAIPDSTEWSVRFKRGTSLLVPKALRFDRFVAGQIPRGWDPKRYGIPEDIVSQVDPTTLYVLVSTVEALVSSGITDPYECYKYIHVSELGNAVGSGVGGMSALRGMYKDRWCDKPVQKDILQESFINSASAWINMLLLSSSGPIKTPVGACATAVESVDAAVEMISSGKAKICIAGGFDDFSEEGSYEFANMGATSNSIKETERGRTPAEMSRPATTTRDGFMEAQGAGVEIVMQAKLAIEMGVPIYGIIGYANTAMDKQGRSVPAPGKGVLTGARELQSKFPSPLLDIKYRARQLKLRRQQISDWAEQEYLYLDEELSAIKSQDPSVNIDDYRLERVAHIKKEIARQDKEALATFGNDFWRKDPSIAPIRGALAVWGLGVDDIGVASFHGTSTVANEKNECDVLDSQLKHLNRSKGNPILGVFQKYLTGHSKGGAGAWMLNGVLQILQTGYVPGNRNADNIDAYMERFDHVMFPSQGIQTDGVRAGSVTAFGFGQVGGQIIAIHPDYVLATLDKDTYEAYIAKTKIRYQASYRYTHDALVNNNLFRAKDHPPYTAEQEKIVYLNPEARAYLDEKTNTYKYASGKPKPKKQPASVSKTASMLDSMTKALAGSSQTVGVDVELIAAINVSNDTFLERNFTEAERSYCSSTPNPQASYAGRWSAKEAVFKSLGVKGQGAGASLKDIEIVASESGAPTVQLHGAAKEAADNAGVKNVSVSISHDDIQSVSVAIAEH
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [630-874]
- IPR040899: Fatty acid synthase subunit alpha, acyl carrier domain (domain) [140-301]
- IPR008278: 4'-phosphopantetheinyl transferase domain (domain) [1724-1820]
- IPR004568: Phosphopantetheine-protein transferase domain (domain) [1721-1839]
- IPR020841: Polyketide synthase, beta-ketoacyl synthase domain (domain) [1076-1613]
- IPR018201: Beta-ketoacyl synthase, active site (active_site) [1250-1266]
- IPR016039: Thiolase-like (homologous_superfamily) [935-1691]
- IPR009081: Phosphopantetheine binding ACP domain (domain) [144-219]
- IPR047224: Fatty acid synthase subunit alpha-like, C-terminal (domain) [1094-1607]
- IPR037143: 4'-phosphopantetheinyl transferase domain superfamily (homologous_superfamily) [1722-1840]
- IPR026025: Fatty acid synthase alpha subunit, yeast (family) [1-1840]
- IPR050830: Fungal fatty acid synthase (family) [6-1678]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [633-813]
- IPR002582: Holo-[acyl carrier protein] synthase (family) [1722-1841]
- IPR041550: Fatty acid synthase type I, helical (domain) [328-528]
- IPR014030: Beta-ketoacyl synthase-like, N-terminal (domain) [1146-1344]
- IPR016035: Acyl transferase/acyl hydrolase/lysophospholipase (homologous_superfamily) [12-63]
- IPR014031: Beta-ketoacyl synthase, C-terminal (domain) [1478-1567]
Interaction partners: - Fatty acid synthase subunit beta
- Acetyl-CoA/biotin carboxylase
- 3-oxoacyl-[acyl-carrier-protein] synthase
- Long-chain-fatty-acid-CoA ligase Lcf1
- Long-chain-fatty-acid-CoA ligase
- 3-oxoacyl-[acyl-carrier-protein] reductase Oar2
- [acyl-carrier-protein] S-malonyltransferase
- 3-hydroxyacyl-ACP dehydratase Htd2
- enoyl-[acyl-carrier-protein] reductase
- Microtubule-associated protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0004312 (fatty acid synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex)