Protein: Chaperone protein DnaK (75 kDa membrane protein) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) (P27542)
Organism: Chlamydia pneumoniae (Chlamydophila pneumoniae)
Function: Acts as a chaperone.
Sequence: MSEHKKSSKIIGIDLGTTNSCVSVMEGGQAKVITSSEGTRTTPSIVAFKGNEKLVGIPAKRQAVTNPEKTLGSTKRFIGRKYSEVASEIQTVPYTVTSGSKGDAVFEVDGKQYTPEEIGAQILMKMKETAEAYLGETVTEAVITVPAYFNDSQRASTKDAGRIAGLDVKRIIPEPTAAALAYGIDKVGDKKIAVFDLGGGTFDISILEIGDGVFEVLSTNGDTLLGGDDFDEVIIKWMIEEFKKQEGIDLSKDNMALQRLKDAAEKAKIELSGVSSTEINQPFITMDAQGPKHLALTLTRAQFEKLAASLIERTKSPCIKALSDAKLSAKDIDDVLLVGGMSRMPAVQETVKELFGKEPNKGVNPDEVVAIGAAIQGGVLGGEVKDVLLLDVIPLSLGIETLGGVMTTLVERNTTIPTQKKQIFSTAADNQPAVTIVVLQGERPMAKDNKEIGRFDLTDIPPAPRGHPQIEVSFDIDANGIFHVSAKDVASGKEQKIRIEASSGLQEDEIQRMVRDAEINKEEDKKRREASDAKNEADSMIFRAEKAIKDYKEQIPETLVKEIEERIENVRNALKDDAPIEKIKEVTEDLSKHMQKIGESMQSQSASAAASSAANAKGGPNINTEDLKKHSFSTKPPSNNGSSEDHIEEADVEIIDNDDK
InterPro domains: - IPR029048: Heat shock protein 70kD, C-terminal domain superfamily (homologous_superfamily) [505-609]
- IPR012725: Chaperone DnaK (family) [7-655]
- IPR013126: Heat shock protein 70 family (family) [10-602]
- IPR018181: Heat shock protein 70, conserved site (conserved_site) [13-349]
- IPR029047: Heat shock protein 70kD, peptide-binding domain superfamily (homologous_superfamily) [381-538]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [8-380]
Interaction partners: - Protein GrpE
- Chaperone protein DnaJ
- Heat-inducible transcription repressor HrcA
- Chaperonin GroEL 1
- Co-chaperonin GroES
- Nitrogen fixation protein NifU
- Chaperone protein ClpB
- Probable ATP-dependent Clp protease ATP-binding subunit
- Chaperonin GroEL 2
- 60 kDa chaperonin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0051087 (chaperone binding), GO:0019904 (protein domain specific binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009408 (response to heat), GO:0006970 (response to osmotic stress), GO:0009266 (response to temperature stimulus), GO:0009268 (response to pH), GO:0104004 (cellular response to environmental stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009651 (response to salt stress), GO:0010447 (response to acidic pH), GO:0071467 (cellular response to pH), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:0034605 (cellular response to heat), GO:0006972 (hyperosmotic response), GO:0071468 (cellular response to acidic pH), GO:0042538 (hyperosmotic salinity response), GO:0071472 (cellular response to salt stress), GO:0071474 (cellular hyperosmotic response), GO:0071475 (cellular hyperosmotic salinity response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)