Protein: Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase X) (DPP X) (Kv4 potassium channel auxiliary subunit) (Q6Q629)
Organism: Rattus norvegicus (Rat)
Function: Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity (Probable).
Subcellular location: Cell membrane {ECO:0000269|PubMed:16123112}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MNQTASVSHHIKCQPSKTIKELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEELLGKGFGLHNPEARWINDTDVVYKTDNGHVMKLNAETNATTLLLDNSTFVTFKASRHSLSPDLKYVLLAYDVKQIFHYSFTASYLIYNIHTGEVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEGIVFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPNMVIPRFTGALYPKAKQYPYPKAGQANPSVKLYVVNLYGPTHTLELMPPDIFKSREYYITMVKWVSNTRTVVRWLNRPQNISILTVCESTTGACSRKYEMTSDTWISKQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHIAMFLVQSKSEQITVRHLTSGNWEVIRILAYDETTQKIYFLSTEFSPRGRQLYSASTEGLLSRDCISCNFRKEDCTYFDASFSPMNQHFLLFCEGPKVPMVSLHSTDNPSNYYILERNSMMKETIQKKKLAKREIRILHIDDYELPLQLSFPKDFLEKNQYALLLIIDEEPGGQMVTEKFHVDWDSVLIDTDNVIVARFDGRGSGFQGLKVLQEIHRRTGSVEAKDQIAAIKYLLKQPYIDSKRLSIFGKGYGGYIASMILKSDEKFFKCGTVVAPISDMKLYASAFSERYLGMPSKEESTYQASSVLHNIHGLKEENLLIIHGTADTKVHFQHSAELIKHLIKAGVNYTLQVYPDEGYHISDKSKHHFYSTILRFFSDCLKEEVSVLPQEPEEDE
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [530-783]
- IPR050278: Serine protease S9B/DPPIV (family) [21-780]
- IPR001375: Peptidase S9, prolyl oligopeptidase, catalytic domain (domain) [581-783]
- IPR002469: Dipeptidylpeptidase IV, N-terminal domain (domain) [133-500]
Interaction partners: - A-type voltage-gated potassium channel KCND3
- Potassium voltage-gated channel subfamily A member 4
- IgLON family member 5
- Calsenilin
- Voltage-gated potassium channel KCNC1
- Leucine-rich glioma-inactivated protein 1
- A-type potassium channel modulatory protein KCNIP1
- A-type voltage-gated potassium channel KCND1
- A-type potassium channel modulatory protein KCNIP2
- Delta and Notch-like epidermal growth factor-related receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051050 (positive regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0060341 (regulation of cellular localization), GO:0043270 (positive regulation of monoatomic ion transport), GO:0032880 (regulation of protein localization), GO:0043268 (positive regulation of potassium ion transport), GO:1904377 (positive regulation of protein localization to cell periphery), GO:0043269 (regulation of monoatomic ion transport), GO:1905477 (positive regulation of protein localization to membrane), GO:1904375 (regulation of protein localization to cell periphery), GO:1905475 (regulation of protein localization to membrane), GO:1903078 (positive regulation of protein localization to plasma membrane), GO:0010959 (regulation of metal ion transport), GO:0043266 (regulation of potassium ion transport), GO:1903076 (regulation of protein localization to plasma membrane)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0044297 (cell body), GO:0009986 (cell surface), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)