Protein: Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C) (O95185)
Organism: Homo sapiens (Human)
Function: Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:25419706}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000269|PubMed:25419706}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}. Cell projection, axon {ECO:0000250|UniProtKB:O08747}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08747}. Cell projection, growth cone {ECO:0000250|UniProtKB:O08747}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O08747}. Cell projection, filopodium {ECO:0000250|UniProtKB:O08747}.
Sequence: MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [62-260]
- IPR042154: UNC5C, death domain (domain) [844-926]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [834-930]
- IPR037936: Netrin receptor UNC5A-D (family) [222-920]
- IPR013098: Immunoglobulin I-set (domain) [168-257]
- IPR033772: UPA domain (domain) [678-817]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [57-259]
- IPR007110: Immunoglobulin-like domain (domain) [175-256]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [260-368]
- IPR003598: Immunoglobulin subtype 2 (domain) [179-246]
- IPR003599: Immunoglobulin domain subtype (domain) [173-258]
- IPR000488: Death domain (domain) [838-929]
- IPR057755: Netrin receptor UNC5A-D-like, N-terminal domain (domain) [57-160]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [259-367]
- IPR000906: ZU5 domain (domain) [528-673]
Interaction partners: - Netrin-1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
- Netrin receptor DCC
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Tyrosine-protein phosphatase non-receptor type 11
- Leucine-rich repeat transmembrane protein FLRT2
- Neogenin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0032103 (positive regulation of response to external stimulus), GO:0048729 (tissue morphogenesis), GO:2000145 (regulation of cell motility), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0003170 (heart valve development), GO:1904018 (positive regulation of vasculature development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0051962 (positive regulation of nervous system development), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0050920 (regulation of chemotaxis), GO:0051130 (positive regulation of cellular component organization), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0050921 (positive regulation of chemotaxis), GO:0030030 (cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0050769 (positive regulation of neurogenesis), GO:0030334 (regulation of cell migration), GO:2001026 (regulation of endothelial cell chemotaxis), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:1901099 (negative regulation of signal transduction in absence of ligand), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0030335 (positive regulation of cell migration), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0048858 (cell projection morphogenesis), GO:0019221 (cytokine-mediated signaling pathway), GO:0007507 (heart development), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0034097 (response to cytokine), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0031344 (regulation of cell projection organization), GO:0051336 (regulation of hydrolase activity), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:1902532 (negative regulation of intracellular signal transduction), GO:0051960 (regulation of nervous system development), GO:0002690 (positive regulation of leukocyte chemotaxis), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0031346 (positive regulation of cell projection organization), GO:0031326 (regulation of cellular biosynthetic process), GO:0010634 (positive regulation of epithelial cell migration), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045765 (regulation of angiogenesis), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0042981 (regulation of apoptotic process), GO:0001938 (positive regulation of endothelial cell proliferation), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0051897 (positive regulation of protein kinase B signaling), GO:0071345 (cellular response to cytokine stimulus), GO:0007411 (axon guidance), GO:0051896 (regulation of protein kinase B signaling), GO:1903131 (mononuclear cell differentiation), GO:0031175 (neuron projection development), GO:0043410 (positive regulation of MAPK cascade), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:0051345 (positive regulation of hydrolase activity), GO:0031401 (positive regulation of protein modification process), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:0043066 (negative regulation of apoptotic process), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006355 (regulation of DNA-templated transcription), GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling), GO:0019220 (regulation of phosphate metabolic process), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0031175 (neuron projection development), GO:0003158 (endothelium development), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0010517 (regulation of phospholipase activity), GO:0061564 (axon development), GO:0045859 (regulation of protein kinase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0060193 (positive regulation of lipase activity), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0048010 (vascular endothelial growth factor receptor signaling pathway), GO:0009414 (response to water deprivation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:2000351 (regulation of endothelial cell apoptotic process), GO:0043507 (positive regulation of JUN kinase activity), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0045860 (positive regulation of protein kinase activity), GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0032589 (neuron projection membrane), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0032590 (dendrite membrane), GO:0031253 (cell projection membrane), GO:0030425 (dendrite)