Protein: Alpha-2 macroglobulin receptor (Q6LBN5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: PMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGS
InterPro domains: - IPR011042: Six-bladed beta-propeller, TolB-like (homologous_superfamily) [1-60]
- IPR001881: EGF-like calcium-binding domain (domain) [498-587]
- IPR051221: Low-density lipoprotein receptor-related (family) [65-348]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [233-502]
- IPR000742: EGF-like domain (domain) [19-587]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [57-502]
- IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [59-504]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0038024 (cargo receptor activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0005102 (signaling receptor binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0044237 (cellular metabolic process), GO:0097242 (amyloid-beta clearance), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051129 (negative regulation of cellular component organization), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0051128 (regulation of cellular component organization), GO:1901343 (negative regulation of vasculature development), GO:0044089 (positive regulation of cellular component biogenesis), GO:1901343 (negative regulation of vasculature development), GO:0044087 (regulation of cellular component biogenesis), GO:0061458 (reproductive system development), GO:0043254 (regulation of protein-containing complex assembly), GO:0007399 (nervous system development), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0044091 (membrane biogenesis), GO:0010628 (positive regulation of gene expression), GO:0008104 (protein localization), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:1900225 (regulation of NLRP3 inflammasome complex assembly), GO:0050808 (synapse organization), GO:0043113 (receptor clustering), GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0005764 (lysosome), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)