wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: NADPH:quinone oxidoreductase MdaB (EC 1.6.5.10) (Modulator of drug activity B) (P0AEY5)
Organism: Escherichia coli (strain K12)
Function: NADPH-specific quinone reductase. Is most active with quinone derivatives and ferricyanide as electron acceptors. Can use menadione, 1,4-naphthoquinone and 1,4-benzoquinone. May work in concert with YgiN to form a quinone redox cycle.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:8611590}.
Sequence: MSNILIINGAKKFAHSNGQLNDTLTEVADGTLRDLGHDVRIVRADSDYDVKAEVQNFLWADVVIWQMPGWWMGAPWTVKKYIDDVFTEGHGTLYASDGRTRKDPSKKYGSGGLVQGKKYMLSLTWNAPMEAFTEKDQFFHGVGVDGVYLPFHKANQFLGMEPLPTFIANDVIKMPDVPRYTEEYRKHLVEIFG
InterPro domains: - IPR003680: Flavodoxin-like fold (domain) [3-188]
- IPR029039: Flavoprotein-like superfamily (homologous_superfamily) [1-193]
- IPR052397: NADPH:quinone oxidoreductase MdaB (family) [1-192]
Interaction partners: - Probable quinol monooxygenase YgiN
- Uncharacterized NAD
- FMN-dependent NADH:quinone oxidoreductase
- Oxygen-insensitive NADPH nitroreductase
- Quinone reductase
- Glutathione-regulated potassium-efflux system ancillary protein KefF
- Oxygen-insensitive NAD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0016651 (oxidoreductase activity, acting on NAD(P)H), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0010181 (FMN binding), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0006979 (response to oxidative stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:1902495 (transmembrane transporter complex)
Protein: Protein THP3 (THO-related protein 3) (Q12049)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Sequence: MQNPYGHFTNNTTEDREASSQGGPFGQSLNRPLDYAGSFPSLTYNNNNFIANQQPSLPLPEPRLSWNNVNQVSNPLMVTPLPGLQKRMNKNIKKKLPRVSKKASALSNGVSGNVMSNSNIVGHGAVGSASGWKVEMGGSDELERRKRRAERFSQGPSATTNSNDNLNEDFANLNAISSKSHQYDKKIHVVGRCQTLEKSYLRLTSEPNPDLIRPPNILQKMYCLLMDKYQSKTATYTYLCDQFKSMRQDLRVQMIENSFTIKVYQTHARIALENGDLGEFNQCQNRIMALFENPTIPKKSYSEFICYSVLYSMLTEDYPSISHLKLKLIDDGSSEILEDEHVKMIFELSDMKLVGNYHYFMKNYLKLHKFEKCLINSFLNLEKLIFLTIICKSYNQVNLDFVKSEFNFNSIEETTNFLNEQNLTEFILNKQITDSNGKSSNIKILNTKGCRVQLIQNYMKSKKIDIKGQK
InterPro domains: - IPR045107: SAC3/GANP/THP3 (family) [50-429]
- IPR005062: SAC3/GANP/THP3, conserved domain (domain) [204-424]
- IPR000717: Proteasome component (PCI) domain (domain) [276-450]
Interaction partners: - Cop9 signalosome complex subunit 12
- 26S proteasome complex subunit SEM1
- 26S proteasome regulatory subunit RPN3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006413 (translational initiation), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0005681 (spliceosomal complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005684 (U2-type spliceosomal complex), GO:0005634 (nucleus)
Protein: Uncharacterized oxidoreductase C4H3.08 (EC 1.-.-.-) (Q10216)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Sequence: MDPVPSTQTQKWPGKHADLDPEPSLLRYCDGRVHVGSGKLAEKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWEGKLDKSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIFSFFWVTKAAISHMKSGSSIVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQHGIRVNAVAPGPIYTPLVSSTFPKEKIELSDQVPLGRMGQPVEVASCYLFLACSDGGYMTGQTLHPNGGTVINN
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [43-283]
- IPR020904: Short-chain dehydrogenase/reductase, conserved site (conserved_site) [179-207]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [44-281]
Interaction partners: - Putative acyl carrier protein, mitochondrial
- Zinc-type alcohol dehydrogenase-like protein C1773.06c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity), GO:0008106 (alcohol dehydrogenase (NADP+) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0044107 (cellular alcohol metabolic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008204 (ergosterol metabolic process), GO:0008202 (steroid metabolic process), GO:0097384 (cellular lipid biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0044108 (cellular alcohol biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0016128 (phytosteroid metabolic process), GO:0006696 (ergosterol biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0016126 (sterol biosynthetic process), GO:0016129 (phytosteroid biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Probable enoyl-CoA hydratase EchA6 (EC 4.2.1.17) (P9WNP1)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Could possibly oxidize fatty acids using specific components.
Sequence: MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKFQGA
InterPro domains: - IPR029045: ClpP/crotonase-like domain superfamily (homologous_superfamily) [5-242]
- IPR018376: Enoyl-CoA hydratase/isomerase, conserved site (conserved_site) [90-110]
- IPR001753: Enoyl-CoA hydratase/isomerase (family) [7-242]
Interaction partners: - Uncharacterized protein Rv0906
- 3-hydroxybutyryl-CoA dehydrogenase
- Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3
- Probable acyl-CoA dehydrogenase FadE23
- Probable acyl-CoA dehydrogenase FadE2
- Acyl-CoA dehydrogenase FadE7
- Possible acyl-CoA dehydrogenase FadE19
- Probable acyl-CoA dehydrogenase FadE1
- Probable acyl-CoA dehydrogenase FadE4
- Probable acyl-CoA dehydrogenase FadE13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0043169 (cation binding), GO:0016836 (hydro-lyase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0000287 (magnesium ion binding), GO:0030145 (manganese ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Guanylate cyclase activating protein 4 (Guanylate cyclase activator 1d) (Q6ZM98)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MGNNHASLDDILAEDMHHWYNKFMRESPSGLITLFELKSILGLQGMNEDANSYVDQVFCTFDMDRDGYIDFVEYIAAISLMLKGEINQKLKWYFKLFDQDGNGKIDKDELETIFTAIQDITRNRDIVPEEIVALIFEKIDVNGEGELTLEEFIEGAKEHPEIMDMLKILMDLTPVLLIIVEGRQK
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [14-170]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [62-152]
- IPR002048: EF-hand domain (domain) [29-162]
- IPR028846: Recoverin family (family) [15-164]
Interaction partners: - Guanylate cyclase
- Guanylate cyclase
- Guanylate cyclase.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0010851 (cyclase regulator activity), GO:0008047 (enzyme activator activity), GO:0030249 (guanylate cyclase regulator activity), GO:0046872 (metal ion binding), GO:0010853 (cyclase activator activity), GO:0030250 (guanylate cyclase activator activity), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009314 (response to radiation), GO:0009416 (response to light stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Riboflavin-binding protein (RBP) [Cleaved into: Riboflavin-binding protein, plasma form; Riboflavin-binding protein, yolk major form; Riboflavin-binding protein, yolk minor form] (P02752)
Organism: Gallus gallus (Chicken)
Function: Required for the transport of riboflavin to the developing oocyte.
Sequence: MLRFAITLFAVITSSTCQQYGCLEGDTHKANPSPEPNMHECTLYSESSCCYANFTEQLAHSPIIKVSNSYWNRCGQLSKSCEDFTKKIECFYRCSPHAARWIDPRYTAAIQSVPLCQSFCDDWYEACKDDSICAHNWLTDWERDESGENHCKSKCVPYSEMYANGTDMCQSMWGESFKVSESSCLCLQMNKKDMVAIKHLLSESSEESSSMSSSEEHACQKKLLKFEALQQEEGEERR
InterPro domains: - IPR004269: Folate receptor (family) [5-218]
- IPR018143: Folate receptor-like (domain) [22-188]
Interaction partners: - Folate_rec domain-containing protein.
- Clusterin
- Ovomucoid
- Ovostatin
- WD repeat and SOCS box containing 2.
- Ovomucoid
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0033218 (amide binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0072341 (modified amino acid binding), GO:0019842 (vitamin binding), GO:0043168 (anion binding), GO:0043177 (organic acid binding), GO:0005542 (folic acid binding), GO:0031406 (carboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051180 (vitamin transport), GO:0071705 (nitrogen compound transport), GO:0072337 (modified amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0042886 (amide transport), GO:0046942 (carboxylic acid transport), GO:0006835 (dicarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031090 (organelle membrane), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: ATP-binding cassette sub-family F member 3 isoform 2 (A0A0S2Z645)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAVGELLQEVSGDSKDDAGIRAVCQRMYNTLRLAEPQSQGNSQVLLDAPIQLSKITENYDCGTKLPGLLKREQSSTVNAKKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRALKLQSWQKSMPNWRRLRLTRHLPGHQSFSLGLALPLKCSSSPPGSSQVAGG
InterPro domains: - IPR003439: ABC transporter-like, ATP-binding domain (domain) [195-227]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [140-294]
- IPR050611: ATP-binding cassette sub-family F member, EF3 subfamily (family) [120-276]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0051246 (regulation of protein metabolic process), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0031399 (regulation of protein modification process), GO:0072663 (establishment of protein localization to peroxisome), GO:0031401 (positive regulation of protein modification process), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0007031 (peroxisome organization), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0072662 (protein localization to peroxisome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Protein SLENDER RICE1-LIKE 2 (OsSLRL2) (Protein SLR1-LIKE 2) (Q6F368)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. Its repressive activity is weaker than that of SLR1. Its overexpression prevents the GA signaling pathway and induces a dwarf phenotype in Arabidopsis thaliana plants.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q7G7J6}.
Sequence: MAQFGGFGGWSAMDVAAAAAAALGNVSGAVYHADPAAAVYASLVPGMAVVPGRAPPSAVQIEAARRWKELEKMALRSVNLMVTCAGAIQAGDYAAAAGSLSDAREIFAKMPTTRTGIGRVLTHFADALAERLFPAFPQSAPPPPPPRGEQRELFRGFYEAGPYLKFAHLAANQAILEAFEGCNSVHVIDFALTDGIQWPSLIQALAVRPGGPPFLRITGIGPHAAGNRDELRDVGLRLAEFARSCSVPFAFRGIAADQLDGLRPWMFQVAPGEAVAINSVLQLHRLLVDQDAAAAASFPAPIDGVLDWVASMNPRVFTVVEQEADHNKSSLLERFTNSLFYYASMFDSLEAISRHGGGDGAGNPLAEAYLQGEIADIVSREGSSRVERHEQMPRWVERLRRGGMTQLPLGATGLWQAAMQLREFSGAGFGVQENGGFLTLTWHSQRLYSASAWRATAGKKMTMMASGAADAMEESQNSNTNGGGGGSSGGGHGALNQIMQ
InterPro domains: - IPR005202: Transcription factor GRAS (family) [68-454]
Interaction partners: - Gibberellin receptor GID1
- F-box protein GID2
- Os07g0143200 protein
- Os04g0618600 protein.
- Helix-loop-helix DNA-binding domain containing protein, expressed
- DELLA protein SLR1
- Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 15
- Transcription factor APG
- Os12g0598200 protein
- Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:1900457 (regulation of brassinosteroid mediated signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: DeHydrogenases, Short chain (P90781)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MSPKSVVVTGSNRGLGFGLVQQFLKDPNVQHVIATARDVDKATALKGICDPRLHILQLSLGSDESIANFAEKVSEIVGESGLTLLINNAAVMLPYVTKQKPDRKVVLDLFESNTIGPMMLTQSLVPLIIKASKRQEGDTLSVSRGAIINIASEFLGSISENTSGSGEYKAMAYRMTKCAVNQFTKTLSIDLKDDHILTAGICPGMVQTDMSKGKGQLTIEESSSQILAAFNKLGATHNGGYFRRDLSIIPY
InterPro domains: - IPR002347: Short-chain dehydrogenase/reductase SDR (family) [4-214]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [4-251]
- IPR051468: Fungal Secondary Metabolite SDRs (family) [1-248]
Interaction partners: - SLC41A/MgtE integral membrane domain-containing protein
- Nuclear receptor domain-containing protein
- NADP-dependent oxidoreductase domain-containing protein
- NADP-dependent oxidoreductase domain-containing protein
- Serine carboxypeptidase ctsa-1.2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004090 (carbonyl reductase (NADPH) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)