Protein: Sperm mitochondrial-associated cysteine-rich protein (P49901)
Organism: Homo sapiens (Human)
Function: Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).
Subcellular location: Cytoplasm. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.
Sequence: MCDQTKHSKCCPAKGNQCCPPQQNQCCQSKGNQCCPPKQNQCCQPKGSQCCPPKHNHCCQPKPPCCIQARCCGLETKPEVSPLNMESEPNSPQTQDKGCQTQQQPHSPQNESRPSK
InterPro domains: - IPR039347: Sperm mitochondrial-associated cysteine-rich protein (family) [1-116]
Interaction partners: - Selenoprotein P
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007018 (microtubule-based movement), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0030317 (flagellated sperm motility), GO:0007283 (spermatogenesis), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0030030 (cell projection organization), GO:0003341 (cilium movement), GO:0051246 (regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0031399 (regulation of protein modification process), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0060294 (cilium movement involved in cell motility), GO:0031401 (positive regulation of protein modification process), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0060271 (cilium assembly), GO:0044458 (motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)