Protein: T-box transcription factor TBX1-A (T-box protein 1-A) (Q8AX98)
Organism: Xenopus laevis (African clawed frog)
Function: Probable transcriptional regulator involved in developmental processes (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (By similarity). Induces pre-placodal ectoderm (PPE) gene expression in regions where RIPPLY3 is absent. Plays a role in the formation of the anteroposterior (AP) axis during embryonic development; required to establish the posterolateral border of the pre-placodal ectoderm (PPE) acting downstream of the retinoic acid receptor (RAR) signaling.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
Sequence: MISAISSPWLTQLSHFCDVAAFTANSLSSLNATGGYHLSPSPGDPYSQHEPHYEPCSASQHSYSFGHACPEPESGASSSSCASSTPGSGSTGSSSSNKAPVKKNPKVANINVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGSLPLMNAFARSRNPVSSPTQNGSDKDGDGRREYERDASGTPLHGDAAHQQLMSRVLSLSLPVPGGLVPLSTGRPSPPHELRLDPHSQGSEPLHHHPYKYPTSYDRYLGAKTRPAPYPLPTIRGHGYHHHHMNPAAANMYSGAGAPGSYEYGPR
InterPro domains: - IPR046360: T-box transcription factor, DNA-binding domain (domain) [109-302]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [109-297]
- IPR001699: T-box transcription factor (family) [63-445]
- IPR036960: T-box superfamily (homologous_superfamily) [97-297]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [119-213]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0048729 (tissue morphogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0009880 (embryonic pattern specification), GO:0009891 (positive regulation of biosynthetic process), GO:0001704 (formation of primary germ layer), GO:0061061 (muscle structure development), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0030111 (regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0048332 (mesoderm morphogenesis), GO:0051252 (regulation of RNA metabolic process), GO:0007498 (mesoderm development), GO:0007517 (muscle organ development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0009952 (anterior/posterior pattern specification), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)