Protein: Transcription initiation factor TFIID subunit 1 (TBP-associated transcription factor 1) (G5EGM3)
Organism: Caenorhabditis elegans
Function: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters via its subunit tbp-1, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of tbp-1 and TBP-associated factors (TAFs), including taf-1 (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Required for early embryonic development. Essential for embryonic transcription of several genes.
Subcellular location: Nucleus {ECO:0000269|PubMed:14726532}.
Sequence: MNNTHHHTNGYRTEKPKNEEDLEDPYANLSDFYKNHPAARNEACSSASNGGSKSVKMEPKVEKNEEFEEYIGDPVRLEDMEPFARPSLRDDAPLSSILHPDLDGIDPRIFFKDFNPNKTLRFSRLFAQNIKHTSRAEIWWASRTFSKHQRKKEPEEPLADDVIVGAKKLKLNIIEKVPRVMLADDEEERMRRPILTDAEEMAKKNEEGTVVQPWRTGPAKIWYDMMNLPMTSQAVNYGFKLKKSPQKVSIRSGKPLNYRTPDDLPSTSSGPAPNSAPFLDKVEVIDKSCEASTSEDILLPYQVIEWENDVILDGEEVKDQLLEEFSNGRGCGWIPTQYTRTYEHFVYAANNNAFEQMFDGKSAPINLTGPDSAILPTPGHSIFPSAPCDLDILPWETNIIWDADAMPSTLEPIDFLVDFQDDPLIYGMPEDRRHDEGPDHHHHHHHHRKDGQYTKKSKMILGQVQQRQKQEEDEQMESTMAQFTDNDPFNLSNDDYYVPKATSKTLSNNSLLIQHSTPATNIATHFFPTHPSAFRLRYWHRTPFTRRIVRHWQPMRFQPIQTPVKHQQRVAAMREAMRQAQGGGEVFYMRDVQDLSGKDETLVMIEYSEEHPVILSQPGMASKMKNYFKRRQANDSEPTFTFGELAFSHQIPFLGQLQPGQSLQSIENMLYRAPIYLHKRQNTDFLLIRSMNQWYIRPLPSIFVAGQQCPLYEVPSPNSKRATVFVRDFLFAFIYRLFWASDSSPRRLKMDDVRNAFPHYAESNIRKRLKMCSTFVRQGSETYWSLKPDFRLPSKEEVLSMVTPEMCCAQYSMMAAEQRLKDAGYGEKYFFTPENDEGSEDEVTIEDEIKCAPWNTTRAFLASQREKCLLDQTGIADPTGCGQGFSYVRVSQKPHKDENATPVPKKLVTGTNADLRKLPLKEAKQICRGYGVKEEEISALTRWEIIDVIRTLSTQAAKATKDGEIIAVSGMARFARGNTRFSSADMQEKYRKHCQRIFDQQNQTLANTDPISTDDDSTDADSDNEELASRLESMLEANKGKKNISMSEKAKIDFETEEKEREDLKRMIHGTTNQVEKGEKKEEGEVTAEEKKSASQFGEDVAMSASKISGITANQQLKIYRTCKGPDGKDVTRIEIVTRPQLIEAYTRIRMTRDDTFIQVYAQMDEQYKEEKRKKKRRLQDQIRRMKKNEEKAAHKVQKMTEKKVKPIKPPNPNLQKMRCSACHAYGHMKTNRNCPLYGKDPLTPLKEEDEGSTIMTSVSSASLVAPDAVQVDGTKVKFNLNFAEIRKEQNREEKLKRKLAKMAEAAVRERQMAHLMEYGGGASSSGGAGGGGSGIGGSTGGGITDNDDDDRFSQISGTSSFLNGPPGAIRGGNRNSSVSGSKRRSSMMPEEDYLQGPLKVAHRARADPKVVMSSMLTDIVNELKMISGSDAFVTPVNSKKVVDYYNIIKNPISLQEIKKKISEQSYLLRKDFLDDIKLMFDNSRMYNGDNNILTLTAQQMLQLAGKRMIEREQKFIGLEKQINPLLDTNDLIGFSYLLGEIVQKMKNIPKSALFHTRVDPKKIPAYYLKISDPMDLSIMEQKSKSQEYKSIDEFLKDAEKIYTNSVVFNGAESVYSLKAKEMFEMAEMLVKDQMDTLGELERNINPSAINDAAAAQRGLAMDSDDHMDEMEDHPTEEEEEDDDDEIMDDDMDIDATGYSYDHDDNVAVGQIFNDLAMSDSDEDERAEDVKRPANGDDNLLDSF
InterPro domains: - IPR011177: Transcription initiation factor TFIID subunit 1, animal (family) [1-1744]
- IPR041670: Zinc knuckle (domain) [1217-1241]
- IPR018359: Bromodomain, conserved site (conserved_site) [1430-1487]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [1376-1651]
- IPR040240: Transcription initiation factor TFIID subunit 1 (family) [17-1647]
- IPR022591: Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain (domain) [489-947]
- IPR001487: Bromodomain (domain) [1406-1636]
Interaction partners: - Transcription initiation factor TFIID subunit 2
- Transcription initiation factor TFIID subunit 10
- TATA-box-binding protein
- Transcription initiation factor TFIID subunit 9
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 4
- Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 13
- PHD-type domain-containing protein
- Transcription initiation factor TFIID subunit 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0042393 (histone binding), GO:0140030 (modification-dependent protein binding), GO:0019900 (kinase binding), GO:0035064 (methylated histone binding), GO:0140034 (methylation-dependent protein binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:2000243 (positive regulation of reproductive process), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:2000241 (regulation of reproductive process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0045165 (cell fate commitment), GO:0045597 (positive regulation of cell differentiation), GO:1905879 (regulation of oogenesis), GO:0030154 (cell differentiation), GO:0018992 (germ-line sex determination), GO:0001708 (cell fate specification), GO:0045595 (regulation of cell differentiation), GO:0007530 (sex determination), GO:0007283 (spermatogenesis), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0060281 (regulation of oocyte development), GO:0040021 (hermaphrodite germ-line sex determination), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)