Protein: methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) (B2R7W0)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [151-323]
- IPR020867: Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site (conserved_site) [104-311]
- IPR020630: Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain (domain) [34-149]
- IPR020631: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain (domain) [144-324]
- IPR046346: Aminoacid dehydrogenase-like, N-terminal domain superfamily (homologous_superfamily) [30-172]
- IPR000672: Tetrahydrofolate dehydrogenase/cyclohydrolase (family) [31-326]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0042301 (phosphate ion binding), GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor), GO:0046872 (metal ion binding), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0000287 (magnesium ion binding), GO:0019238 (cyclohydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0043603 (amide metabolic process), GO:0006766 (vitamin metabolic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0043436 (oxoacid metabolic process), GO:0006760 (folic acid-containing compound metabolic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0046655 (folic acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046653 (tetrahydrofolate metabolic process), GO:0043648 (dicarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005576 (extracellular region), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen)