Protein: 5-hydroxytryptamine receptor 1A (5-HT-1A) (5-HT1A) (Serotonin receptor 1A) (P19327)
Organism: Rattus norvegicus (Rat)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Subcellular location: Cell membrane {ECO:0000269|PubMed:2156831}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08908}. Cell projection, dendrite {ECO:0000269|PubMed:18685031}.
Sequence: MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [53-400]
- IPR002231: 5-hydroxytryptamine receptor family (family) [57-406]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [38-415]
- IPR000610: 5-Hydroxytryptamine 1A receptor (family) [7-332]
Interaction partners: - Basigin
- Fibroblast growth factor receptor 1
- Sodium-dependent serotonin transporter
- 5-hydroxytryptamine receptor 2A
- Guanine nucleotide-binding protein G
- Oxytocin-neurophysin 1
- Guanine nucleotide-binding protein G
- Pro-neuropeptide Y
- 5-hydroxytryptamine receptor 2C
- Somatostatin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0019904 (protein domain specific binding), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0001664 (G protein-coupled receptor binding), GO:0050780 (dopamine receptor binding), GO:0004952 (dopamine neurotransmitter receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0044706 (multi-multicellular organism process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0044703 (multi-organism reproductive process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0003012 (muscle system process), GO:0099536 (synaptic signaling), GO:0007565 (female pregnancy), GO:0045933 (positive regulation of muscle contraction), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0044057 (regulation of system process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0007210 (serotonin receptor signaling pathway), GO:0003013 (circulatory system process), GO:0010033 (response to organic substance), GO:0071417 (cellular response to organonitrogen compound), GO:0010243 (response to organonitrogen compound), GO:0008015 (blood circulation), GO:0071310 (cellular response to organic substance), GO:0006936 (muscle contraction), GO:1901699 (cellular response to nitrogen compound), GO:0045987 (positive regulation of smooth muscle contraction), GO:0045987 (positive regulation of smooth muscle contraction), GO:0090257 (regulation of muscle system process), GO:0014070 (response to organic cyclic compound), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:1901701 (cellular response to oxygen-containing compound), GO:0006937 (regulation of muscle contraction), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0043279 (response to alkaloid), GO:0071312 (cellular response to alkaloid), GO:0060047 (heart contraction), GO:0006940 (regulation of smooth muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0098590 (plasma membrane region), GO:0043679 (axon terminus), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0097060 (synaptic membrane), GO:0098984 (neuron to neuron synapse), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0032279 (asymmetric synapse), GO:0030424 (axon)