Protein: Cohesin subunit SA (A0A0R4IZR5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate
Subcellular location: Chromosome. Nucleus. Chromosome, centromere
Sequence: MIAAPELQTEFHYPQDTDTRFSSDTDFDDPDGRNAIIGKGKAKKGKKGPGEKGKGMGKGVGRMNGHHQENGMENVMLFEVVRLGKSAMQSVVDDWIESYKHDRDVALLDLINFFIQCSGCKGVVSGEMFRNMQNSEIIRKMTEEFDEDSGDYPLTMTGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANDRLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYHNRELNAKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLHSSDEVLTAEDCESVYHLVYSAHRPVAVAAGEFLFKKLFSHRDPEDDSMPKRRGRQSVNANLIKTTVFFFLESELHEHAAYLVDSMWDCAAELLKDWECMISLLLDEPLPGEEALTDRQETALIEILLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTRMTELFAIALPALLAKYSVDAEKVTNLLQLPQFFDLEIYTTGRLEKHLDSLLRQIREIVEKHTDTDVLEACSKTYHSLCNEEFTIFNRVDIARSQLLDEQVDKFNKLLEDFLQEGEDPDEDDAYQVLSTLKRISAFYNAHDLSKWDLFTSNYKLLNTGIENGDMPEQIVVHALQCTHYVILWSLAKVSEGCYKKEDMLTLRKQMRAFCLMCQRYLTSVNTAVKEQAFTILCDLLLIFSHQIISGGREALEPLVYTPEASLQSELLNFILDHVFIDQDEDSNSTDGQQDDEAGKIEALHKRRNLLAAYCKLIIYNVVEMSTGADIFKQYMRYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMLSELGPSFDRSSSAFCGIKELARRFSLTFGLDQLKTREAIAMLHKDGIEFAFKEANPQGDGHPPLNLAFLDILSEFSSKLMRQDKRTVHMYLERFMTFQMALQREDCWLPLISYRNSLQAGGDDDTMSVVSGISSRGSSVRSKKAKPATAKRKLPEEESSSSSEVWMSREQSMQTPVMMPSPHLTSTIMREPKRLRPEESYMGVYTMTPDQQQQHTHPHTPQPQHHQTPMDYNTQVTWMLAQRQQQEEVARQQQERAMNYAKLRSNLQHAIRRGTGLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERSELKPDFFDPASIMDESVRSTHFLGYDAFQR
InterPro domains: - IPR039662: Cohesin subunit Scc3/SA (family) [18-1122]
- IPR016024: Armadillo-type fold (homologous_superfamily) [169-791]
- IPR020839: Stromalin conservative domain (domain) [286-371]
- IPR013721: STAG (domain) [151-252]
- IPR056396: Cohesin subunit SCC3/SA, HEAT-repeats domain (domain) [472-736]
Interaction partners: - Double-strand-break repair protein rad21 homolog A
- Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
- separase
- Double-strand-break repair protein rad21-like protein 1
- RAD21 cohesin complex component b
- Nipped-B-like protein B
- Sister chromatid cohesion protein PDS5 homolog A
- PDS5 cohesin-associated factor B
- Cell division cycle-associated 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0035295 (tube development), GO:0007059 (chromosome segregation), GO:1903047 (mitotic cell cycle process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016043 (cellular component organization), GO:0007062 (sister chromatid cohesion), GO:0000278 (mitotic cell cycle), GO:0098813 (nuclear chromosome segregation), GO:0055123 (digestive system development), GO:0140014 (mitotic nuclear division), GO:0007064 (mitotic sister chromatid cohesion), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0048565 (digestive tract development), GO:0000819 (sister chromatid segregation), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)