wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: G protein-coupled receptor 101 (E7FA10)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MPTFPPLGSNSSTVPWDPGAALSPSLVNSTVKMVLISAIVCTSLFGNIVVLLVFQRKPQLLHVANRFVLNLLLADLLQTVLVMPFAIAATVPEVWPLDARLCQALVVLMHLFAFAGVNTIIVVSIDRYLAIIHPLSYPTRMTPHLGTNLIALTWLVSVLQSTPPLYGWGTIDFDRRHNACTVVWSSSYSYSALVSALSFWLPVVIMLCCYWMVFRAARRQNALVHPIQSNPPLDSQASCSSPQRQQQSQQETFSASYPIRTRQRRFQYHCKAARVVFVIMASYVLSMGPYSVLSTISIYSSAAVPPWLASTALILFFLQCCLHPYIYGYMHRSVRKEFLALLCGPFCGQGRISQGSAVDSCFTVTDGRLAHNNLSNQAARVCPLRTWEEGTTSSSPTERRSKDSRKETTSISLSSEKELTVHSTANKQPEETSTGNF
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [46-327]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [31-335]
Interaction partners: - PWWP domain-containing 2B
- Ankyrin repeat and SOCS box protein 12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032879 (regulation of localization), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0051049 (regulation of transport), GO:0001568 (blood vessel development), GO:1905952 (regulation of lipid localization), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0032368 (regulation of lipid transport), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0032371 (regulation of sterol transport), GO:0032374 (regulation of cholesterol transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Nuclear transcription factor Y subunit gamma (A0A8M3B3Q2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors
Subcellular location: Nucleus
Sequence: MSADSFGAGGSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDDLKPPKRQEEVRQSVAPTEPVQYYFTLAQQPSAVQVQGQQQGQQVSAPTATTLQPGQIIIAQPQQGQSAPVTMQVGEGQQVQIVQAAAQGQAQAQTAQPAGQTMQVMQQIITNTGEIQQIPVQLNTGQLQYIRLAQPVSGTQVVQGQIQTLAANTQQLSQTEVQQGQQQFNQFTDGQQLYQIQQVTMPAGQELTQPMFIQSTNQTADGQVTTQVSAD
InterPro domains: - IPR050568: Transcription/DNA replication regulator (family) [11-171]
- IPR009072: Histone-fold (homologous_superfamily) [8-118]
- IPR007125: Core Histone H2A/H2B/H3 domain (domain) [26-103]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)
Protein: Transcriptional enhancer factor TEF-5 (F1Q968)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Subcellular location: Nucleus
Sequence: MDKTGMDGDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKMREYQAGIKDQASKDKALQNMAALSSAQIVSASVMKSQLPPLPQHPYPPPARFWPGPIPGQPGPSQDIKPFAPSPYPTLQPPPISSYEQLPAPLPPSATAVPVWQDRTIASSKLRMLEYSAFMEVQRDPDTYSKHLFVHIAQTNPSYTDPLLEAVDIRQIYDKFPEKKGGLKELYEKGPQNAFFLVKFWADLNSSNVQDGAGSFYGVSSQYSSAENMTITVSTKVCSFGKQVVEKVETEYARVEGGRYVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAFVFEVSTSDHGAQYHVYRLVKD
InterPro domains: - IPR050937: TEC1/TEAD Transcription Factor (family) [6-405]
- IPR041086: YAP binding domain (domain) [192-402]
- IPR016361: Transcriptional enhancer factor, metazoa (family) [4-405]
- IPR038096: TEA/ATTS domain superfamily (homologous_superfamily) [6-86]
- IPR027253: Transcriptional enhancer factor TEF-5 (TEAD3) (family) [2-405]
- IPR000818: TEA/ATTS domain (domain) [5-83]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Probable N-acetyltransferase camello (A0A8M1PSN6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MDEVQIRQYREEDLEEVKEVFTIGMSEHIPSSCMHVLKQPLAQMFLGCVFCALLTSSMSILLPVLAVTLLLAAGRQSVCYMFNKYIQTSLEQDLSHIQQTYMDPPNACVWVAESQGRVVGTVGCFPSENDKNFLELKRMSVKKAHRGKGIAKALCRTVADFARERGYLGVILHTSVVQTDAQKLYEHMGYHKVREFSAPEFIAKLTNFTLMEYQLIVKRHN
InterPro domains: - IPR050769: N-acetyltransferase, camello-type (family) [2-214]
- IPR000182: GNAT domain (domain) [68-216]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [1-196]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0060026 (convergent extension)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Kringle-containing protein marking the eye and the nose (B0BLV6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MDSWRVAALLLAVCFSASATEHFHTECYTANGEDYRGRQNQTSLQGGRPCLFWNETFERPYNTNKYPNGEGGLGQHNFCRNPDGDVRPWCYIADLEDGSYWKYCDIPTCQMPGNLGCFKDSGDPTPLSGSHQTSTKLTIQNCISFCRNQRYKLAGMESGYACFCGDDREYHRHGDAPNTECNHVCFGDHTQPCGGDGRIIVFDTKVGACGGNFTSPSAVIYSPDFPGKYRSGSVCYWTIQVPGSSVILFNFTFFSIVDQKDMVELLDGKTNQVVARFDGRNPPRDIVNITADFVILYFYSDRTNEALGFSVVYHALRNPAFRPEEEDNGDEEDTSTMRPNSGSTTTKSNTSQSGKSSHLYYVITSSPANMPGQWHGPGRTAGHNTMWTIYALAALLTLTVIAMVAKLLLHLTVKSPSIPSISGSESCAQSTTSEPWIILYRPSTISLFKKKLKNHHGDLSPLVGN
InterPro domains: - IPR035914: Spermadhesin, CUB domain superfamily (homologous_superfamily) [202-315]
- IPR013806: Kringle-like fold (homologous_superfamily) [22-120]
- IPR038178: Kringle superfamily (homologous_superfamily) [12-113]
- IPR051836: Kremen receptor (family) [3-397]
- IPR000859: CUB domain (domain) [209-316]
- IPR000001: Kringle (domain) [25-111]
- IPR002889: Carbohydrate-binding WSC (domain) [111-205]
- IPR018056: Kringle, conserved site (conserved_site) [78-90]
Interaction partners: - Low density lipoprotein receptor-related protein 5
- Dickkopf WNT-signaling pathway inhibitor 3b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Claudin (Q90XR0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia
Subcellular location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Sequence: MSMGLEIGGIALGIIGWIISIVACALPMWRVSAFVGANIVTAQVIWEGLWMNCVVQSTGQMQCKVYDSMLALGQDLQASRAMTVIAIILAVLGVMISVMGAKCTNCIEDEGAKAKVMIVSGIMFIIAGILDLIPSAWVANQIIRDFYNPLLPGAQQRELGASIYIGFAAAALLIIGGAMLCCTCPPKEKKYKPARMGYSAPRSASAGYDKKDYV
InterPro domains: - IPR017974: Claudin, conserved site (conserved_site) [48-63]
- IPR003549: Claudin-3 (family) [5-207]
- IPR006187: Claudin (family) [3-191]
- IPR004031: PMP-22/EMP/MP20/Claudin (family) [3-180]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0007369 (gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0055113 (epiboly involved in gastrulation with mouth forming second), GO:0060429 (epithelium development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0001702 (gastrulation with mouth forming second), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction), GO:0043296 (apical junction complex), GO:0070160 (tight junction), GO:0005923 (bicellular tight junction)
Protein: Nociceptin receptor (Q7T3Q4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin
Subcellular location: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle
Sequence: MEFPNDSIGFTDPRHFHLYNESLFQNNFSTFNESDSFFPKGFKITIAVVYMIVCVVGLVGNCLVMYVIIRYTKMKTATNIYIFNLALADALVLATLPFQGTDVFLGFWPFGNALCKVVVSIDYYNMFTSVFTLTVMSMDRYVAVCHPVKALDMRTPHKAKVVNICVWVLASAIGVPAMVLGDVEQDNGESIECILVLPDPRSYWDPVFGTCVFLLSFLIPVAIISVCYSLMVKRLRSVRILSGSKEKDRNLRRITRMVLVVVAAFVVCWTPIQIMALAQSLGFNLASVQTVVFMHFCIALGYVNSSLNPVLYAFLDENFKRCFREFCHPSRFGIDAQQSGRMRHITREVAFNCKTTDGNSNPA
InterPro domains: - IPR001420: X opioid receptor (family) [99-361]
- IPR001418: Opioid receptor (family) [70-323]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [45-327]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [60-312]
Interaction partners: - Proenkephalin a
- Pro-opiomelanocortin protein
- Proenkephalin-B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0042277 (peptide binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0042923 (neuropeptide binding), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: BMERB domain-containing protein 1 (Q4V8S6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MELQQALSGTGGGIEMYGALQETHTGDVSMAERSVSAEEIEAEMSRIQRLREVLVRRESELRFMMDDIQLCREIMSLKQELRKTVRVPDAEKTKQQRQTEEKLILQIHTLVQKRDYLVEDAEVERLREQEEDQEMAEFLRQKLGVIQKAPKPRVTEIPANKPSISRTSAAVLRDCCGATSCAIM
InterPro domains: - IPR040127: BMERB domain-containing protein 1 (family) [1-184]
- IPR022735: bMERB domain (domain) [1-137]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Pannexin 1 (Q7ZUN0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi- pass membrane protein
Sequence: MAIAHAATEYVFADFVLKDPASENRYKGIRLDLALDKIVTCVAVGLPLLLISLAFAQEVSVGTQISCFAPTAFSWCQAAYVDSYCWAAVQKQDTGGLPLWLHKFFPYILLLVAVSVYMPALFWRFTGAPVLSSDLTFIMEELDRSYNRAIKLAKCLHTAGKVETPPAPVDTNSSVIDLTESYFKYPLVEQYLRTKRYSKGLLIRYLLCRTITVLALTLACIYLCYYISLSTTDEFSCDIRSGVVVNDSSVPPALQCKLVAVGIFQLLSYINLSVYLLLLPLCMFAMLVPFRRTKGFLKPFEMLPTIGVMQFGQATWDDLALYLLFLEENLSELKSYKCLKVLELLKEQGDESFDPMLLLRTLGQVKTDVVDGRLPQKDQKISSTNNGDTELKEFAPLLPEDCLRKHEDEKAVRQRVI
InterPro domains: - IPR039099: Pannexin (family) [1-415]
- IPR000990: Innexin (family) [28-383]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015267 (channel activity), GO:0022829 (wide pore channel activity), GO:0022836 (gated channel activity), GO:0022832 (voltage-gated channel activity), GO:0005243 (gap junction channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0001503 (ossification), GO:0048856 (anatomical structure development), GO:1904888 (cranial skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0032587 (ruffle membrane), GO:0001726 (ruffle), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane)
Protein: ubiquitinyl hydrolase 1 (A0A0R4ITP2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAQQLDEEERMRMAEGGVQTEEYRTFLQQPSGNMDDSGFFSIQVISNALGVWGLEIVLFNSREYQQLQMDPMHEKAFICNYKEHWFTVRKLGQQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVIRGNLPECEADQILRIMRVEQQQRPKLIGEEEAQRMSAPHASETTHTAEEPVLDEDEEELRKALALSRQDLQVEDEEADLRRAIQMSMQGSSDAGSSAPAGGSSEKQTLSAEELRRRRQAYFDRQQNAQDSSSSTGGGTDSGPKPTQ
InterPro domains: - IPR033865: Machado-Joseph disease protein (family) [3-296]
- IPR006155: Josephin domain (domain) [1-180]
- IPR003903: Ubiquitin interacting motif (conserved_site) [219-258]
Interaction partners: - Transitional endoplasmic reticulum ATPase
- Ubiquitin-ribosomal protein eS31 fusion protein
- E3 ubiquitin-protein ligase CHIP
- Protein deacetylase HDAC6
- UV excision repair protein RAD23
- Ataxin 1b
- Beclin-1
- Ubiquitin-like-conjugating enzyme ATG3
- Polyubiquitin-C
- Polyubiquitin-B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0021551 (central nervous system morphogenesis), GO:1904888 (cranial skeletal system development), GO:0048731 (system development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005886 (plasma membrane), GO:0043229 (intracellular organelle), GO:0005635 (nuclear envelope), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Sulfurtransferase (A4QP04)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion
Sequence: MAAQTRALVAARWLADAVKSNRVGPNLRILDASWYLPKMKRNPRAEFEQTHIPGASFFDIDECCDKSSEFDHMLPTKGEFADYVGNLGIGNNTHVVVYDASDFGSFSAPRVWWMFRVFGHSSVSVLDGGFKNWLKEGHPVSQQYSKPAPVDFNASFKESWVKTYEDVLNNIKTKEFQVVDARANGRFRGVEPEPRANTEPGHIPASLNMPFPSFMDPESGLERPVEELTKLFQQAGVDLQKPFWVTCGSGVTACHIALAAHLCGHPGVSLYDGAWSEWFTKAAPEHIISEGKGKQP
InterPro domains: - IPR045078: Sulfurtransferase TST/MPST-like (family) [4-294]
- IPR001307: Thiosulphate sulfurtransferase, conserved site (conserved_site) [47-278]
- IPR001763: Rhodanese-like domain (domain) [13-287]
- IPR036873: Rhodanese-like domain superfamily (homologous_superfamily) [2-296]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0016783 (sulfurtransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)