Protein: Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] (Q9QYR6)
Organism: Mus musculus (Mouse)
Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Sequence: MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFPGGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLLQRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPDKLRLPDASRKAKRSIEEACLTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQKWAGNSKAKTGIVLANGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKILEGLEKLRHLDFLRYPVATQKDLAAGAVPANLKPSKIKHRADSKESLKAAPKTAMSKLAKREEVLEEGAKEARSELAKELAKSEKKAKEPSEKPPEKPSKPERVRTESSEALKAEKRKLIKDKVGKKHLKEKISKLEEKRDKEKKEIKKERKELKKEEGRKEEKKDAKKDEKRKDTKPELKKFSKPDLKPFTPEVRKTLYKAKAPGRLKVDKGRAARGEKELSSEPRTPPAQKGAAPPPAASGHRELALSSPEDLTQDFEELKREERGLLAEPRDTELGEKPLPADASEQGRPSTAIQVTQPPASVLEQEQVEREKEVVPDFPEDKGSKNRAPDSGAEVEREKETWEERKPREAELTPENIAAAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEETKAESFYQKHMQEALKVIPKGREALGGRELGFQGKAPEKETASFLSSLATPAGAAEHVSYIQDETIPGYSETEQTISDEEIHDEPDERPAPPRFPTSTYDLSGPEGPGPFEASQSAESAVPASSSKTYGAPETELTYPPNMVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCEDFSVTGESEKKGESVGRGLTGEKAVGKEEKNVTTSEKLSSQYAAVFGAPGHALHPGEPALGEVEERCLSPDDSTVKMASPPPSGPPSAAHTPFHQSPVEEKSEPQDFQEDSWGDTKHAPGVSKEDAEEQTVKPGPEEAMSEEGKVPLSRSPQAQDTLGSLAGGQTGCTIQLLPEQDKAVVFETGEAGAASGAGSLPGEVRTQEPAEPQKDELLGFTDQSFSPEDAESLSVLSVVSPDTAKQEATPRSPCTPKEQQLHKDLWPMVSPEDTQSLSFSEESPSKETSLDISSKQLSPESLGTLQFGELSLGKEEKGPLVKAEDNSCHLAPVSIPEPHTATVSPPTDEAAGEAGLTDESPAGNLPGSSFSHSALSGDRKHSPGEITGPGGHFMTSDSSLTKSPESLSSPAMEDLAMEWGGKAPGSEDRATEQKEKELERKSETLQQKDQILSEKAALVQRDSVMHQKDEALDEENKPGGQQDKTSEQKGRDLDKKDTAVELGKGPEPKGKDLYLEDQGLAEKDKALEQRGAALQQTQAPEPRARAQEHRDLEQKDEHLELRDKTPEEKDKVLVLEDRAPEHIIPQPTQTDRAPEHRSKVDKEQKDEASEEKEQVLEQKDWAREKEGAALDQDNRAAGQKDGTLKEDKTQGQKSSFLEDKSTTPKEMTLDQKSPEKAKGVEQQDGAVPEKTRALGLEESPEEEGKAREQEEKYWKEQDVVQGWRETSPTRGEPVPAWEGKSPEQEVRYWRDRDITLQQDAYWKELSCERKVWFPHELDGQGARPRYSEERESTFLDEGPNEQEITPLQHTPRSPWASDFKDFQEPLPQKGLEVERWLAESPVGLPPEEEDKLTRSPFEIISPPASPPEMTGQRVPSAPGQESPVPDTKSTPPTRNEPTTPSWLAEIPPWVPKDRPLPPAPLSPAPAPPTPAPDPHAPAPFSWGIAEYDSVVAAVQEGAAELEGGPYSPLGKDYRKAEGEREGEGGAGAPDSSSFSSKVPEVTESHTTRDAEQTEPEQREPTPYPDERSFQYADIYEQMMLTGLGPACPTREPPLGASGDWPPHLSTKEEAAGRNKSAEKELSSAVSPPNLHSDTPTFSYASLAGPTIPPRQEPEPGPNVEPSFTPPAVPPRAPISLSQDPSPPLNGSTTSCGPDRRTPSPKEAGRSHWDDGTNDSDLEKGAREQPEKETQSPSPHHPMPVGHPSLWPETEAHSSLSSDSHLGPVRPSLDFPASAFGFSSLQPAPPQLPSPAEPRSAPCGSLAFSGDRALALVPGTPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLPRPASPALSEGSSSEATTPVISSVAERFPPGLEVAEQSSGELGPGNEPAAHSLWDLTPLSPAPLASRDLAPAPAPAPAPSLPGNLGDGTLSCRPECSGELTKKPSPFLSHSGDHEANGPGETSLNPPGFATATAEKEEAEALHAWERGSWPEGAERSSRPDTLLSSEQRPGKSSGGPPCSLSSEVEAGPQGCATDPRPHCGELSPSFLNPPLPPSTDDSDLSTEEARLAGKGGRRRAGRPGATGGPCPMADETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGDFLPVDKAGGVSGTHHPRPGHDPPPAPLPDPRPPPPRPDVCMADPEGLSSESGRVERLREKVQGRPGRKAPGRAKPASPARRLDIRGKRSPTPGKGPVDRTSRALPRPRSTPSQVTSEEKDGHSPMSKGLVNGLKAGSTALGSKGSSGPPVYVDLAYIPNHCSGKTADQDFFRRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQTHEQQQQLNVLVLASSSTVVMQDESFPACKIEF
InterPro domains: - IPR057480: Microtubule-associated protein 1A/B/S-like, MBL-like domain (domain) [18-301]
- IPR036866: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like (homologous_superfamily) [43-103]
- IPR026074: Microtubule associated protein 1 (family) [1-1497]
Interaction partners: - Sequestosome-1
- Microtubule-associated protein 1 light chain 3 beta
- Disks large homolog 4
- Microtubule-associated protein 1 light chain 3 alpha
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
- Beclin-1
- Ubiquitin-like protein ATG12
- BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
- Calcium-binding and coiled-coil domain-containing protein 2
- FUN14 domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0051049 (regulation of transport), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0016358 (dendrite development), GO:0048731 (system development), GO:0060341 (regulation of cellular localization), GO:0016043 (cellular component organization), GO:0032886 (regulation of microtubule-based process), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0048813 (dendrite morphogenesis), GO:0032880 (regulation of protein localization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0032386 (regulation of intracellular transport), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0051493 (regulation of cytoskeleton organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0005829 (cytosol), GO:0030054 (cell junction), GO:0001750 (photoreceptor outer segment), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043025 (neuronal cell body), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0099572 (postsynaptic specialization), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0032279 (asymmetric synapse), GO:0097733 (photoreceptor cell cilium), GO:0005856 (cytoskeleton), GO:0097730 (non-motile cilium), GO:0097731 (9+0 non-motile cilium), GO:0015630 (microtubule cytoskeleton)