Protein: Probable RNA-binding protein 19 (RNA-binding motif protein 19) (Q8R3C6)
Organism: Mus musculus (Mouse)
Function: Plays a role in embryo pre-implantation development.
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Chromosome. Note=Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to nucleolar precursor body (NPB) (By similarity). In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the NPB. During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development. {ECO:0000250}.
Sequence: MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQAALNHFHRSFIDTTRITVEFCKSFGDPSKPRAWSKHAQKSSQPKQPSQDSVPSDTKKDKKKKGPSDLEKLKEDAKFQEFLSIHQKRTQVATWANDALEAKLPKAKTKASSDYLNFDSDSNSDSGQESEEEPAREDPEEEQGLQPKAAVQKELSDMDYLKSKMVRAEVSSEDEDEEDSEDEAVNCEEGSEEEEEEGSPASPAKQGGVSRGAVPGVLRPQEAAGKVEKPVSQKEPTTPYTVKLRGAPFNVTEKNVIEFLAPLKPVAIRIVRNAHGNKTGYVFVDLSSEEEVKKALKCNRDYMGGRYIEVFREKQAPTARGPPKSTTPWQGRTLGENEEEEDLADSGRLFVRNLSYTSSEEDLEKLFSAYGPLSELHYPIDSLTKKPKGFAFVTFMFPEHAVKAYAEVDGQVFQGRMLHVLPSTIKKEASQEANAPGSSYKKKKEAMDKANSSSSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETRGSVAVRVALGETQLVQEVRSFLIDNGVCLDSFSQAAAERSKTVILAKNLPAGTLAAEIQETFSRFGSLGRVLLPEGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPIGVFGAAPQKKDSQHEQPAEKAEVEQETVLDPEGEKASVEGAEASTGKMEEEEEEEEEEEEESIPGCTLFIKNLNFSTTEETLKGVFSKVGAIKSCTISKKKNKAGVLLSMGFGFVEYKKPEQAQKALKQLQGHTVDGHKLEVRISERATKPALTSTRKKQVPKKQTTSKILVRNIPFQANQREIRELFSTFGELKTVRLPKKMTGTGAHRGFGFVDFITKQDAKKAFNALCHSTHLYGRRLVLEWADSEVTVQTLRRKTARHFQEPPKKKRSAVLDGILEQLEDEDNSDGEQALQL
InterPro domains: - IPR034423: Probable RNA-binding protein 19, RNA recognition motif 5 (domain) [722-801]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [3-904]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [1-930]
- IPR034417: Probable RNA-binding protein 19, RNA recognition motif 2 (domain) [293-364]
- IPR051945: RRM MRD1 RNA Processing and Ribosome Biogenesis (family) [392-814]
- IPR003954: RNA recognition motif domain, eukaryotic-type (domain) [401-799]
- IPR034418: Probable RNA-binding protein 19, RNA recognition motif 1 (domain) [2-77]
- IPR000504: RNA recognition motif domain (domain) [2-904]
- IPR034421: Probable RNA-binding protein 19, RNA recognition motif 6 (domain) [824-902]
- IPR034419: Probable RNA-binding protein 19, RNA recognition motif 3 (domain) [398-476]
- IPR034420: Probable RNA-binding protein 19, RNA recognition motif 4 (domain) [584-655]
Interaction partners: - BMS1 homolog, ribosome assembly protein
- Periodic tryptophan protein 2 homolog
- U3 small nucleolar ribonucleoprotein protein IMP4
- Protein RRP5 homolog
- Pescadillo homolog
- Protein AATF
- Ribosome biogenesis protein WDR12
- Surfeit locus protein 6
- Bystin
- Probable ATP-dependent RNA helicase DDX10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0055123 (digestive system development), GO:0048546 (digestive tract morphogenesis), GO:0048565 (digestive tract development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)