Protein: Cardioactive peptide (Cardioacceleratory peptide 2a) (Crustacean cardioactive peptide) (CCAP) (Q8WRC7)
Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Function: Cardioregulatory neurohormone that increases heart beat rate during adult wing inflation; has no effect on beat amplitude. The effect of CCAP is both ino- and chronotropic.
Subcellular location: Secreted {ECO:0000269|PubMed:3925062}.
Sequence: MTVSRVCLLLLVALVYLDCCYAASIPRNFDPRLSEEIVMAPKKRPFCNAFTGCGRKRSQGPPGMPAQDLRTKQYLDEEALGSILDSESAIDELSRQILSEAKLWEAIQEASAEIARRKQKEAYIQ
InterPro domains: - IPR024276: Crustacean cardioactive peptide (family) [4-121]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0071855 (neuropeptide receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065008 (regulation of biological quality), GO:0023056 (positive regulation of signaling), GO:0055085 (transmembrane transport), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0002027 (regulation of heart rate), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0034220 (monoatomic ion transmembrane transport), GO:0023061 (signal release), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0007218 (neuropeptide signaling pathway), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0046903 (secretion), GO:1902533 (positive regulation of intracellular signal transduction), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:1902531 (regulation of intracellular signal transduction), GO:0050850 (positive regulation of calcium-mediated signaling), GO:0006812 (monoatomic cation transport), GO:0050848 (regulation of calcium-mediated signaling), GO:0050848 (regulation of calcium-mediated signaling), GO:0019229 (regulation of vasoconstriction), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)