Protein: Sorting nexin-12 (Q9USN1)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MYQQHIFYFITGGIFILWILAHSFFVKIIYLWASGCLLWYCLETRTFENKNNLGTSEPFLVNPAIFQKRARQLALSKLLLRQPLYPGIPEISEEIESIISHFMQKYIKVWSYQIIPEPTISNSIESHLRKCLMVLLSRVDEIDLADVLVKTVLPLITKHLRLFVEAEQLVVGNKAVSFTDHSELSREVAAKYDHGRLHEAVLLSGNPMVAQKRYLRNWTTQVLSIILPNYYETSPLVLSLVTEVIINTTLLPLVSYISDPDFFNYLIIQASGSIIQRRRKIRRLKRAIRKQSNHFQVGARRLRLKDSQHSFEQYIHEIKKISNISDARRLRSELMVQRRQLEQTEAFDFEFKQYRERLQIAIITAEKRISLLSGTPFQHKEAVLFEQVQSLLQILSDSAAVSCFLEFMERKNRSRYLHFWLVVEGLKESQDDPLNAHMIAPFSDIVSDHTDFTAIVKSYFESVDNPLDIPKPLTNTINKFVNQSKDNLNPDLWVEARNAMLMAQEHVFDIMQNSDYSEFVNSEIYYRFLAQDVVSDHKSTNSSATFSRLEELGENIPAISKQPSYLSISSSSKSINSSPSPSIQLSVSSSISRDKNLSPLDLELDDPTYSDEEEVLFAPPGDLQLSESIDELNNNIEELKAQLNAINTLIKKAELVADQKQLKSLTKNHQEIEKAIHRKERQRDQYMSQEEDSKLFNRSRVSIDSFKISKEENTPDFAVYTIRIERLENGHVRSGWMVARRYREFAELHKQLKQTYPGVRSLKFPQKSIITSLNKNVLEYRRGALEEYLQSLFRMPEVCDSKMLRMFLSQQNITAPQMFNPKEVGKKWKQLLEVLGFEVNNSFNASNVNTNSSFSGPISEFLVELFSPNDDAKQQWLPKKTYISILEQLFGGALEKRIRLQLFQLFTPEKIYRKLREFRRGLEGKSNHDHSKDRRHSRARKPAYADRNQLKAEAGILLASMFPGYTPDIAVKRIFRILQNQSLNAHVIYTLLDEILLALKKHARSTNKAT
InterPro domains: - IPR044926: RGS, subdomain 2 (homologous_superfamily) [381-533]
- IPR016137: RGS domain (domain) [390-529]
- IPR001683: Phox homology (domain) [695-815]
- IPR036305: RGS domain superfamily (homologous_superfamily) [389-532]
- IPR003114: Phox-associated domain (domain) [88-275]
- IPR036871: PX domain superfamily (homologous_superfamily) [685-817]
Interaction partners: - Meiotically up-regulated gene 122 protein
- PXA domain protein 1
- PX domain-containing protein C1450.12
- tRNA
- Uncharacterized protein C663.15c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005543 (phospholipid binding), GO:0035091 (phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0022406 (membrane docking), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051651 (maintenance of location in cell), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0051640 (organelle localization), GO:0140056 (organelle localization by membrane tethering), GO:0016043 (cellular component organization), GO:0051643 (endoplasmic reticulum localization), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:1990849 (vacuolar localization), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0032418 (lysosome localization), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0072384 (organelle transport along microtubule), GO:0061024 (membrane organization), GO:0097352 (autophagosome maturation), GO:0007033 (vacuole organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)