Protein: BOS complex subunit TMEM147 (Q9BVK8)
Organism: complex subunit TMEM147 {ECO:0000305};
Function: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein
Sequence: MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLCSLGSWAALLARAVVTGLLALSTLALYVAVVNVHS
InterPro domains: - IPR019164: Transmembrane protein 147 (family) [1-220]
Interaction partners: - BOS complex subunit NCLN
- BOS complex subunit NOMO2
- PAT complex subunit CCDC47
- Calcium load-activated calcium channel
- Protein transport protein Sec61 subunit alpha isoform 1
- Protein transport protein Sec61 subunit beta
- Large ribosomal subunit protein eL32
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0042127 (regulation of cell population proliferation), GO:0001817 (regulation of cytokine production), GO:0010941 (regulation of cell death), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050764 (regulation of phagocytosis), GO:0080164 (regulation of nitric oxide metabolic process), GO:0070663 (regulation of leukocyte proliferation), GO:0043067 (regulation of programmed cell death), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0042981 (regulation of apoptotic process), GO:0032944 (regulation of mononuclear cell proliferation), GO:0045428 (regulation of nitric oxide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)