wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Double-stranded RNA-binding protein Staufen homolog 1 (F1Q5V4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site
Subcellular location: Cytoplasm. Rough endoplasmic reticulum
Sequence: MSQLQFQAPGNPAPSSAPLQLAPPQPGFSIPCGTAPLPSESASHPLRNSALPSASATPFCNPTVSNMANPKEKTPMCLVNELARYNKIQPEYKLLSEEGPAHSKIFSVRLTLGDQHWDAEGTSIKKAQHSAASSALAQTTLPKPSHRSPRHPDNVTHTVELNALCMKLGKKPIYKPIDAYQGMRPAFNYNIRAPSPYARSMQHYYYPFPPVGPVLYHMELSIGGQQFHGKGRTRQAAKHDAAAKAIKYLQKEPILQQITEMTDEPAQENLNKSEISQVFEIALKRNMPVDFEVLKEAGAPHMKSFVVRVVVGEFAGEGEGKSKKIAKKQAAIAVLEELRRLPQLPATDKIPLRIKKKSKSIIKLQTSPEYGQGMNPISRLAQIQQAKKEKEPEYTLVTERGLPRRREFVMQVSVAGQNAEGMGPSKKVAKRNAAEKMLELLGFKVPQPQPPKPALKTDEKPPAKKLGDGRKVTFFEPGSMEKAGLVVSKEEDFRLPFLSHQQLPAGILPMVPEVAQAVGANQGPHAKDYGRTAAPNPANATVTAMIANELLYAGTSPTAEGILKTNNSLAHRPQGPLTRPSEQLSYLANVQGLQVEYKDFPKNNKNEFVSLINCSSQPPLISHGIGKDVESCHDMAALNILKLLSELDQQSNERTANGPMSGCTKQDLEGDALLKPANSSTMGKTLDGTA
InterPro domains: - IPR014720: Double-stranded RNA-binding domain (domain) [74-443]
- IPR032478: Staufen, C-terminal (domain) [538-648]
- IPR044475: Staufen 1, third double-stranded RNA binding domain (domain) [272-338]
- IPR051740: Double-stranded RNA-binding domain-containing protein (family) [21-687]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048468 (cell development), GO:0030154 (cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Platelet-derived growth factor beta polypeptide a (A0A8M9Q3E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MMSSRLLLLVLAALAACLRSGRAQGDPLPPSLVDLVMNSPISTVDDLKKLLDVESVEEDDEKPETEMHSNGTHKRLPRSLSIQVAQQAMCKVRTEVMEVTRAMFDRRNANFMLWPSCVEVQRCSGCCNARTLQCVPVITETRHLQITKIQYINRQPSYEKVVIPVEDHVTCSCQLRVPAQPPRVQTTPLPPPRLLPKVTPPKTQSKEELHRNDELKHNQQLHLEDKESQELQWQSKYTVAHTDRQTPHQHTLTHTPAYASRGDFPTRQTTLGNPHMMSDATQTEEADHIKSEHSGDDMAKKTTYKHSHEEQPFNRTTPQQPKSPSQTSVQSERGISSQSDTLTRTYSHVEVIGQSSGLSEVLTHQSDQSEVRKRHHHSHQSEKQEEMHHLRHQHHQHHQRHQFTTQAVSKQQTSTQRTVMKAPPTTPSAPQTPPPLPSPRKRRRKHRKRISKASMRAMIMVMS
InterPro domains: - IPR023581: Platelet-derived growth factor, conserved site (conserved_site) [115-127]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [25-180]
- IPR000072: PDGF/VEGF domain (domain) [75-178]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048645 (animal organ formation), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0016477 (cell migration), GO:0048863 (stem cell differentiation), GO:0060914 (heart formation), GO:0048864 (stem cell development), GO:0003007 (heart morphogenesis), GO:0072359 (circulatory system development), GO:0060973 (cell migration involved in heart development), GO:0002009 (morphogenesis of an epithelium), GO:0060029 (convergent extension involved in organogenesis), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0001667 (ameboidal-type cell migration), GO:0007507 (heart development), GO:0014033 (neural crest cell differentiation), GO:0060026 (convergent extension), GO:0003318 (cell migration to the midline involved in heart development), GO:0014032 (neural crest cell development), GO:0060974 (cell migration involved in heart formation), GO:0090497 (mesenchymal cell migration), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: Leucine-rich glioma-inactivated protein 1 (F6NUE1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Secreted. Synapse
Sequence: MCLRRAAVLCVLLAALVLGGRRRSSRCPAPCTCSKDNALCANTGAIPRSFPQDVISLSFVKSGFTEIPKESFIHTPALHLLLFTANSFDSINEDAFLGLPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLETLPKDLFKGMEALTKVDLRGNLFSCDCKLKWLVDWMFHTNATVDQIFCNGPEGYQGKKINDLEAQTFDCITTDFTLLKSLEFQSISVEAFSFAGDQFVVFAQPFSGRCSFMEWDHVQMEFRNFDNITSTSTVICKPLVIDSQLFIIVAQLFGGSHIFKRDVSANKFIRIQDIDILKIRKPNDVEIFEVDGESFFIIADSSKAGSTTIYKWNGNGFYSYQSLHPWHRDTDVEYLDISGKPHLILSSSSQRPVVYQWSRGSAQFERRTDIPEMEDVFAVKHFTVKNELYICLTRFIGDSKVMRWDGSMFTEIQTVASRGSMVFQPFSVASWQYAILGSDYAFTRVYRWDAKKRQFVPFQELNIQAPRAFSLVFIDNREFLLGSSFKGQTRIYEHLVLDLSS
InterPro domains: - IPR011041: Soluble quinoprotein glucose/sorbosone dehydrogenase, beta-propeller domain superfamily (homologous_superfamily) [292-527]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [158-207]
- IPR009039: EAR (repeat) [210-531]
- IPR051295: Leucine-rich glioma-inactivated/LGI-related (family) [6-535]
- IPR005492: Leucine-rich glioma-inactivated , EPTP repeat (repeat) [211-529]
- IPR001611: Leucine-rich repeat (repeat) [101-159]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [99-146]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [24-212]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007272 (ensheathment of neurons), GO:0007610 (behavior), GO:0008366 (axon ensheathment), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007626 (locomotory behavior), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0042552 (myelination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: protein-serine/threonine phosphatase (A0A8M1P874)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion matrix
Sequence: MSVALLVRYATLSGSRVCSRAAFNLTNAHQEDPRRALHTPSSPRFSNSRFDPDSSGRPTTWDSFGIWDNRIDEPILLPSSIRYGKLIPKVNLSRVGSASQIGQRKENEDRYQMSQMTDNIMYFAVFDGHGGAEAADFCHKNMEKHIKDIAAEETNLEFVLTKAFLEVDKALARHLHFSADASVLSAGTTATVALLRDGIELVVGSVGDSRAMMCRKGKAVKLTVDHTPERKDEKERIRRSGGFITWNSLGQPHVNGRLAMTRSIGDFDLKATGVIAEPETKRISLHHVHDSFLALTTDGINFIMNSQEICDVINQCHDPKEAAQRISEQALQYGSEDNSTIIVVPFGAWGKHKSSEVSFSFSRSFVSSGRFA
InterPro domains: - IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [83-358]
- IPR000222: PPM-type phosphatase, divalent cation binding (binding_site) [122-130]
- IPR015655: Protein phosphatase 2C (family) [56-345]
- IPR001932: PPM-type phosphatase-like domain (domain) [84-346]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0035295 (tube development), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0055123 (digestive system development), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0072359 (circulatory system development), GO:0048732 (gland development), GO:0007417 (central nervous system development), GO:0048565 (digestive tract development), GO:0061008 (hepaticobiliary system development), GO:0031016 (pancreas development), GO:0007507 (heart development), GO:0042981 (regulation of apoptotic process), GO:0001889 (liver development), GO:0043066 (negative regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Kinesin-like protein (F1RAK1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm, cytoskeleton
Sequence: MAVNFGRIVVGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLECIFSLNPDVAPEEEISLSPVTPPPPTPSSVKVNKIPKNRRTIAPGRSEIPSRDNRVGSTRARPAQQLQQQQQQQPQPQPESAPPPPAQQPSQPTQSQTQSQLTQQQQQNARRKSNCVKEVEKLQEKRERRRLQQQELREKRAQEVDTTIPNYEILQMIRDFRGSLDYRPLTTTDLIEEHRICVCVRKRPLNKKELSVKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSTTNEMVYRFTARPLVETIFDRGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLDLQVYATFFEIYSGKVFDLLNRKAKLRVLEDGKQQVQVVGLQEREVKCTEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKMHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPNAVTEGIRPNVNAINQLDIMDEEWELGNSPQRDDLKLLCEQNEEEVSPQLFTFHEVVSQLVDMEEQVLEDHRAVFQESIRWLEDEKVLLEMTEEVDYDVDSYSSQLEQILDQKIEILIELRDKVRSFRSALQEEEQASKQINPKRPRAL
InterPro domains: - IPR054473: Kinesin-like protein KIF2A-like, N-terminal (domain) [5-59]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [207-568]
- IPR027640: Kinesin-like protein (family) [35-571]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [208-566]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [464-475]
- IPR001752: Kinesin motor domain (domain) [234-574]
Interaction partners: - Serine/threonine-protein kinase PLK
- Cell division cycle 20 homolog
- Kinesin-like protein
- Centromere-associated protein E
- Serine/threonine-protein kinase Nek2
- Abnormal spindle-like microcephaly-associated protein
- Kinesin family member 11
- Kinesin family member 21A
- Kinesin-like protein
- BUB1 mitotic checkpoint serine/threonine kinase Ba
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0044087 (regulation of cellular component biogenesis), GO:0031344 (regulation of cell projection organization), GO:1902115 (regulation of organelle assembly), GO:0033043 (regulation of organelle organization), GO:0060491 (regulation of cell projection assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1902017 (regulation of cilium assembly), GO:0120032 (regulation of plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Ribose-phosphate pyrophosphokinase 1 (Q4KME9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Sequence: MPNIKIFSGSSHPDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKVGSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENINEWKNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTVCHAADKLVSAGAIKVYAILTHGIFSGPAISRINNANFEAVVVTNTIPQEDKIKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
InterPro domains: - IPR000842: Phosphoribosyl pyrophosphate synthetase, conserved site (conserved_site) [130-145]
- IPR029099: Ribose-phosphate pyrophosphokinase, N-terminal domain (domain) [4-122]
- IPR037515: Ribose-phosphate pyrophosphokinase, bacterial-type (family) [4-316]
- IPR029057: Phosphoribosyltransferase-like (homologous_superfamily) [6-308]
- IPR000836: Phosphoribosyltransferase domain (domain) [149-276]
- IPR005946: Ribose-phosphate pyrophosphokinase (family) [1-318]
Interaction partners: - Uridine 5'-monophosphate synthase
- transketolase
- Transketolase
- Phosphoglucomutase-2
- ADP-ribose pyrophosphatase, mitochondrial
- ADP-sugar pyrophosphatase
- Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
- Ribose-phosphate pyrophosphokinase 1
- Phosphoribosyl pyrophosphate synthase-associated protein 2
- Elongation factor Ts, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016778 (diphosphotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Protein phosphatase 1A (A0A286Y912)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor. Nucleus
Sequence: MGAFLDKPKMEKHNAHGDGNSLRYGLSSMQGWRVEMEDAHTAVIGLPNSLDLWSFFAVYDGHAGSQVARYCCEHLLEHITSNPDFQGGGGGGGPAVEPSVDSVKSGIRTGFLQIDDHMRQISEKKHGGADRSGSTAVGVMISPRHIYFINCGDSRGLLSRGGAVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVCAIERSEAEDEFIVLACDGIWDVMANEELCDFVRSRLEVTDDLERVCNEIVDTCLYKGSRDNMSVVLVCFVSAPKVSPEAVKREAELDKYLESRVEEILKRQGDEGVPDLVHVMRTLASESIPNLPPGGELASKRSVIEAVYNKLNPYRNEDTDSASTDDMW
InterPro domains: - IPR015655: Protein phosphatase 2C (family) [19-296]
- IPR000222: PPM-type phosphatase, divalent cation binding (binding_site) [55-63]
- IPR001932: PPM-type phosphatase-like domain (domain) [13-298]
- IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [1-302]
- IPR036580: Phosphatase 2C, C-terminal domain superfamily (homologous_superfamily) [303-376]
- IPR012911: Protein serine/threonine phosphatase 2C, C-terminal (domain) [292-371]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Ribosomal RNA-processing protein 7 homolog A (Q568T7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MAPSANKDACVIPGGFTVLSLRFSEDDSAAALHQVCVKEHRVRSESNTHRPADRTLFVLNVPPYCTQSVLSGVFSRFGVVESVDVCVKPGAADSSASGVCELFRVQEPQCFRVAYVVFRSAASVNAAKRHPLHDPLIASTAERPVRTGLRKWIQQYSGSLVKASSLQAAVDQFMEEFDTRKQQEAERLQQEAEQQQEDEEGWVKVTKGSRGAKARPHTETANQRTLQKEEKKKQRKELLNFYSWQHRNTQREHIAELRKKFEEDKQRIAVLRAQRKFKPY
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [51-130]
- IPR040446: Ribosomal RNA-processing protein 7 (family) [12-280]
- IPR034890: Rrp7A, RNA recognition motif (domain) [54-156]
- IPR024326: Ribosomal RNA-processing protein 7, C-terminal domain (domain) [161-280]
- IPR000504: RNA recognition motif domain (domain) [54-152]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [24-146]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: E3 ubiquitin-protein ligase RNF220 (Q08CD0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MEEELQSNGKRETFLRVRANRQTRLNARIGKMKRRKPEDGQVCPLCSAPLAGTEEEMSRHVEQCLFKREGATEEDSADVEGENGTRFEEYEWCGQKRVRATTLLEGGFRGTGFAMCSTKESHDSDADLDVDGDDTLEYGKAQYTEADIIPCSGEDQGEAKEREALRGAVLNGGVPSNRITPEFSKWASDEMPSTSNGESSKQEPSSSSSSSTQRTCKNSEIEKITEDSTATTLEALKARIRELEKQILRGDRYKCLICMDSYTMPLTSIQCWHVHCEECWLRTLGNKKLCPQCNTITSPGDLRRVYL
InterPro domains: - IPR040178: E3 ubiquitin-protein ligase RNF220, RING finger (domain) [253-304]
- IPR001841: Zinc finger, RING-type (domain) [254-294]
- IPR031824: E3 ubiquitin-protein ligase RNF220, middle domain (domain) [5-177]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [236-307]
- IPR052443: E3 ubiquitin-protein ligase RNF220-like (family) [3-307]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0021514 (ventral spinal cord interneuron differentiation), GO:0021953 (central nervous system neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)