Protein: Leucine-rich repeats and immunoglobulin-like domains protein 1 (LIG-1) (Q96JA1)
Organism: Homo sapiens (Human)
Function: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:15282549}; Single-pass type I membrane protein {ECO:0000305|PubMed:15282549}.
Sequence: MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAPKS
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [40-494]
- IPR050467: Leucine-rich repeat and fibronectin type-III domain-containing (family) [442-694]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [494-781]
- IPR013098: Immunoglobulin I-set (domain) [599-780]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [495-783]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [40-72]
- IPR007110: Immunoglobulin-like domain (domain) [495-779]
- IPR003598: Immunoglobulin subtype 2 (domain) [507-770]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [66-428]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [440-490]
- IPR003599: Immunoglobulin domain subtype (domain) [501-781]
- IPR001611: Leucine-rich repeat (repeat) [116-440]
- IPR025875: Leucine rich repeat 4 (repeat) [71-110]
Interaction partners: - Hepatocyte growth factor receptor
- Epidermal growth factor receptor
- E3 ubiquitin-protein ligase CBL
- Receptor tyrosine-protein kinase erbB-2
- Leucine-rich repeats and immunoglobulin-like domains protein 3
- Pro-epidermal growth factor
- Leucine-rich repeats and immunoglobulin-like domains protein 2
- Receptor tyrosine-protein kinase erbB-4
- Homeodomain-only protein
- Proto-oncogene tyrosine-protein kinase receptor Ret
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048857 (neural nucleus development), GO:0030901 (midbrain development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021762 (substantia nigra development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)