Protein: Catenin alpha-1 (Alpha E-catenin) (Q9PVF8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell junction, adherens junction {ECO:0000269|PubMed:10456847, ECO:0000269|PubMed:20736288}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P26231}. Cell membrane {ECO:0000250|UniProtKB:P26231}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:P26231}. Cell junction {ECO:0000269|PubMed:10456847, ECO:0000269|PubMed:16319113, ECO:0000269|PubMed:27612508}. Cytoplasm {ECO:0000269|PubMed:10456847}. Nucleus {ECO:0000269|PubMed:20736288}. Note=Localized in the ooplasm during the initial stages of oogenesis. {ECO:0000269|PubMed:10456847}.
Sequence: MTSINTANINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNSSNKGPSNKKKGRSKKAHVLAASVDEATQNFLEKGEKIAKESQFLKEELTAAVEDVRKQGESMKMASGEFAEDPCSSVKRGNMVRAARALLSAVTHLLVLADMADVYQLLLQLKLVEENLMKVRNAGTEQDLGIQYKALKPEVDKLNMMAAKRQQELKDVHHKDQMAAARGVLQRNVPMLYTASRACLQHPDVAAYKANRDLIYKQLQHAVSGISNAAQATSSEDSSFSQTAGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNSVRQALQDLLSEYMGNAGRKEKSDALNTAIDRMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMAASQLETLCPQVINAALALAAKPNSKVAQDNMDLFKDQWEKQVRVLTDAVDDITSIDDFLCVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVVHVVTSEMDNYMPGVYTEKVLEATKLLTETVMPRFTEQVEAAVEALSANNGQPVDENEFIDASRLVYDGVRDIRKAVLMIRTPEELDDSDFETEDFDSRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRAIADQCPDSACKQDLLAYLQRIALFCHQLNICSKVKAEVQNLGGELVVSGLDSAMSLIQAAKNLMNSVVSTVKASYVASTKYQKSQDMQSLNMPAISWKMKAPEKKPLVKREKLDDGQTNKVKRSSQKKHINPVQALSEFKAMDSI
InterPro domains: - IPR000633: Vinculin, conserved site (conserved_site) [178-198]
- IPR006077: Vinculin/alpha-catenin (family) [19-867]
- IPR001033: Alpha-catenin (family) [12-873]
- IPR036723: Alpha-catenin/vinculin-like superfamily (homologous_superfamily) [58-861]
Interaction partners: - Catenin beta-1
- Catenin, beta 2.
- Vinculin b.
- Vinculin a.
- Afadin, adherens junction formation factor a.
- Junction plakoglobin a.
- Tight junction protein 1a
- Actinin, alpha 4.
- Actin, cytoplasmic 1
- Catenin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005516 (calmodulin binding), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005262 (calcium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005245 (voltage-gated calcium channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0030048 (actin filament-based movement), GO:0010171 (body morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0002064 (epithelial cell development), GO:0070252 (actin-mediated cell contraction), GO:0007417 (central nervous system development), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0016331 (morphogenesis of embryonic epithelium), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0030855 (epithelial cell differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0022607 (cellular component assembly), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043009 (chordate embryonic development), GO:0035315 (hair cell differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0061572 (actin filament bundle organization), GO:0030031 (cell projection assembly), GO:0009913 (epidermal cell differentiation), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0021955 (central nervous system neuron axonogenesis), GO:0021952 (central nervous system projection neuron axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction), GO:0044291 (cell-cell contact zone), GO:0014704 (intercalated disc)