Protein: Cytoskeletal signaling protein slm1 (O94447)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Effector of the TORC2- and calcineurin-signaling pathways. Mediates actin polarization via inhibition of calcineurin-dependent transcription (By similarity).
Subcellular location: Cell tip {ECO:0000269|PubMed:21900489}.
Sequence: MELSGKSEFPTRTEIPNQASNGDAVPNTDAYMGLCNSLTYRFEGWRHLVENLIAFFKQLESTSKNNAKEYMKLSKVIVHPYKDANVFEEHGIQDIFAALRDQTAAIASDSEQISIQLPGTIINILELLREDLREHCKKIAAEGTKGVKVVEKQRAETQKYLSLLDRALLPWRASSPPTVNIKNDPFIVDRQVLNCLARQVQEENNHSVAVAQLQEFSFRFEQNLIAKIKDTVKQFEGMMNQTHVKAINHLQEVVRVSEAQTLAGEWTGYAKREPEFIHGSVPPRSVDAIKYPGKNDQPTVPIMAGYLIRKTSFLKKKQRGFYAFTHSGYLYEFKSSDSLQDPEPEFALYIPDCLIGRPSEKKPKFKITGKDATKKIFGARNDYAFRASNNTELMRWWEALNTHIANVNYIQPLSNANGPSAVSDSDDDDDDPNDFRPAVERQSSTMNTRMSQPSSAVNTNRSYGSEQIPSYADSQGNSGANNNFIYNASATGHNAWNV
InterPro domains: - IPR046868: SLM1/RGC1-like, BAR-like domain (domain) [89-272]
- IPR001849: Pleckstrin homology domain (domain) [300-407]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [35-263]
- IPR046869: SLM1/RGC1-like, PH domain (domain) [291-370]
- IPR043453: Slm1, PH domain (domain) [299-405]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [296-405]
Interaction partners: - Probable sphingolipid long chain base-responsive protein pil1
- Large ribosomal subunit protein uL22m
- Large ribosomal subunit protein uL15m
- Small ribosomal subunit protein uS15m
- Translation initiation factor IF-2, mitochondrial
- Small ribosomal subunit protein uS14m
- Meiotically up-regulated gene 33 protein
- Large ribosomal subunit protein uL3m
- Target of rapamycin complex 2 subunit bit61
- Large ribosomal subunit protein uL11m
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0035091 (phosphatidylinositol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0007163 (establishment or maintenance of cell polarity), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0033036 (macromolecule localization), GO:0044085 (cellular component biogenesis), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0033365 (protein localization to organelle), GO:0006897 (endocytosis), GO:0051017 (actin filament bundle assembly), GO:0061572 (actin filament bundle organization), GO:0061572 (actin filament bundle organization), GO:1990778 (protein localization to cell periphery)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)