Protein: Golgi brefeldin A resistant guanine nucleotide exchange factor 1 (A0A669KB10)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Golgi apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
Sequence: MVDKNIYIIQGEINIVVGAIKRNARWSTHTPLDEERDPLLHSFGHLKEVLNSITELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKNYVGTNMKKISPCLLNKLELSSGEQTKALNQLERLKMRAGGMSDSSKWKKQKRSPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASAVVSPSTDSGLEFSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEELTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGLHLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIFLRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPAALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDVDNSKPGPSRPGPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSKEGSMLRRPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPMEPQGQKPLASAHLTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQPLASPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [60-1191]
- IPR000904: Sec7 domain (domain) [717-909]
- IPR035999: Sec7 domain superfamily (homologous_superfamily) [715-912]
- IPR023394: Sec7, C-terminal domain superfamily (homologous_superfamily) [798-923]
- IPR032691: Mon2/Sec7/BIG1-like, HUS domain (domain) [427-576]
- IPR056604: GBF1-like, tetratricopeptide repeats domain (domain) [1563-1741]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0005543 (phospholipid binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0043168 (anion binding), GO:0035091 (phosphatidylinositol binding), GO:0030695 (GTPase regulator activity), GO:0005547 (phosphatidylinositol-3,4,5-trisphosphate binding), GO:0080025 (phosphatidylinositol-3,5-bisphosphate binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0048870 (cell motility), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0007163 (establishment or maintenance of cell polarity), GO:0042330 (taxis), GO:0006955 (immune response), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0050900 (leukocyte migration), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0002252 (immune effector process), GO:0006903 (vesicle targeting), GO:0051640 (organelle localization), GO:0097529 (myeloid leukocyte migration), GO:0061339 (establishment or maintenance of monopolar cell polarity), GO:0044085 (cellular component biogenesis), GO:0030010 (establishment of cell polarity), GO:0072593 (reactive oxygen species metabolic process), GO:0060341 (regulation of cellular localization), GO:0051649 (establishment of localization in cell), GO:0051648 (vesicle localization), GO:0048199 (vesicle targeting, to, from or within Golgi), GO:0051726 (regulation of cell cycle), GO:0046907 (intracellular transport), GO:1903409 (reactive oxygen species biosynthetic process), GO:0051656 (establishment of organelle localization), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0002263 (cell activation involved in immune response), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0016477 (cell migration), GO:0006935 (chemotaxis), GO:0071621 (granulocyte chemotaxis), GO:0097530 (granulocyte migration), GO:0007346 (regulation of mitotic cell cycle), GO:0030030 (cell projection organization), GO:0010256 (endomembrane system organization), GO:0032880 (regulation of protein localization), GO:0061162 (establishment of monopolar cell polarity), GO:0051650 (establishment of vesicle localization), GO:0022607 (cellular component assembly), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0060326 (cell chemotaxis), GO:0016197 (endosomal transport), GO:0016482 (cytosolic transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0061024 (membrane organization), GO:0006900 (vesicle budding from membrane), GO:0070925 (organelle assembly), GO:0006895 (Golgi to endosome transport), GO:0033365 (protein localization to organelle), GO:0030593 (neutrophil chemotaxis), GO:0030031 (cell projection assembly), GO:0016050 (vesicle organization), GO:0120036 (plasma membrane bounded cell projection organization), GO:1990266 (neutrophil migration), GO:1903008 (organelle disassembly), GO:0048193 (Golgi vesicle transport), GO:0007030 (Golgi organization), GO:0048308 (organelle inheritance), GO:0042147 (retrograde transport, endosome to Golgi), GO:2000008 (regulation of protein localization to cell surface), GO:0044782 (cilium organization), GO:0006892 (post-Golgi vesicle-mediated transport), GO:0060271 (cilium assembly), GO:0034067 (protein localization to Golgi apparatus), GO:0070972 (protein localization to endoplasmic reticulum), GO:0006890 (retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)