wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Hsc70Cb, isoform A (Hsc70Cb, isoform B) (Hsc70Cb, isoform C) (Hsc70Cb, isoform E) (Hsc70Cb, isoform F) (Hsc70Cb, isoform I) (LD32979p) (Q9VUC1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSVIGIDFGNESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKRLLGRKFNDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQTQVNDCVIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDLFEDKPRNVIFVDFGHSSLQASACAFTKGKLKMLASTWDQIGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEIEKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKLQLDDIHSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTDIQNYAVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYGQQVPYPDQTIGVWKVKDVKPTERGEGQDVKLKVRINNNGIVLISSATLVEKKEAEEAAAAAEQAASEEKPGDQTNNTGEPADGQQEGADKKKKASKATELPLECTTHGFSPVDLSNYTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVEAEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIAIARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEVQTLNSCVSSVINRAKPKPTPAKTATPPKDEANAEQNGGEPAANSGDKMDVDNNGQSAAGNDPSMEVE
InterPro domains: - IPR029048: Heat shock protein 70kD, C-terminal domain superfamily (homologous_superfamily) [554-663]
- IPR013126: Heat shock protein 70 family (family) [1-776]
- IPR018181: Heat shock protein 70, conserved site (conserved_site) [335-349]
- IPR029047: Heat shock protein 70kD, peptide-binding domain superfamily (homologous_superfamily) [384-586]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [1-379]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0051082 (unfolded protein binding), GO:0017022 (myosin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0006950 (response to stress), GO:0008340 (determination of adult lifespan), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0035966 (response to topologically incorrect protein), GO:0006986 (response to unfolded protein)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: 60S ribosomal protein L19 (C6KSY6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MSLTLQKRLAASVLKCGKNKIWMDPNEISEISLANSRFSIRKLYKEGLILKKPQKVHSRARVRLYKLAKRKGRHMGIGKRKGTKNARTNQKTLWIKRQRVLRRLLKRLRDSKKVDRHLYHSFYLKCKGNQFKNKRTLIEAIQREKNETLKKKAIADQLEAKRLKAQVLRNKRKLKKDKEVVA
InterPro domains: - IPR035970: Large ribosomal subunit protein eL19 superfamily (homologous_superfamily) [1-142]
- IPR000196: Large ribosomal subunit protein eL19 domain (domain) [1-150]
- IPR033935: Large ribosomal subunit protein eL19, eukaryotic (domain) [3-166]
- IPR057259: Ribosomal protein L19e, N-terminal domain (domain) [3-54]
- IPR057260: Ribosomal protein L19e, C-terminal domain (domain) [55-145]
- IPR039547: Large ribosomal subunit protein eL19 (family) [2-176]
- IPR015972: Large ribosomal subunit protein eL19, domain 1 (homologous_superfamily) [1-55]
Interaction partners: - 40S ribosomal protein S21
- 40S ribosomal protein S27
- 40S ribosomal protein S24
- 40S ribosomal protein S6
- 60S ribosomal protein L35ae, putative
- 60S ribosomal protein L13
- 60S ribosomal protein L26, putative
- 60S ribosomal protein L6, putative
- 60S ribosomal protein L18-2, putative
- 60S ribosomal protein L29
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0044391 (ribosomal subunit), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0043228 (non-membrane-bounded organelle), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0005840 (ribosome)
Protein: Catenin alpha-1 (G3XAM7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell junction, adherens junction {ECO:0000256|ARBA:ARBA00004536}. Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGNCDTCGALQGLKGWPPPLCWPLTGWTAPCP
InterPro domains: - IPR000633: Vinculin, conserved site (conserved_site) [178-198]
- IPR006077: Vinculin/alpha-catenin (family) [19-812]
- IPR001033: Alpha-catenin (family) [12-799]
- IPR036723: Alpha-catenin/vinculin-like superfamily (homologous_superfamily) [58-804]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding), GO:0003676 (nucleic acid binding), GO:0042802 (identical protein binding), GO:0050839 (cell adhesion molecule binding), GO:0008092 (cytoskeletal protein binding), GO:0045296 (cadherin binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0071417 (cellular response to organonitrogen compound), GO:1901699 (cellular response to nitrogen compound), GO:0097305 (response to alcohol), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:0097306 (cellular response to alcohol), GO:0071407 (cellular response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005886 (plasma membrane)
Protein: GRASP65 homolog protein 1 (Q04410)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in the spindle assembly checkpoint. Involved in ER to Golgi vesicle-mediated transport by either facilitating USO1-dependent and -independent tethering or increasing target accuracy of fusion events of COPII-coated vesicles.
Subcellular location: Cytoplasm. Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Note=Localizes to cytoplasm in a punctate pattern. Association with the cis-Golgi requires N-terminal acetylation and is probably mediated via an N-terminal amphipathic helix. The localization to the Golgi is MAK3-dependent and SYS1-independent. Localizes to the Golgi together with BUG1.
Sequence: MFRIAKNLVRTFEQSVQDTLALSQDSSNLDAFFQSIPPNLLSAQLESPVDAVSEGVKHTNVNETLSGLRIVWVDEMQFQLQSFFDYIVGFNDDPVPVVSNQHGFSYPDYRRITSIFNEHCGRTLKVNIWSAKGGTFRDEYISIISKESDDLDDVSLNHDERRPSSGEAHQFQALGFKVQWTPLIASTFTYHILNVNIPDGPAQSAGLIPDEDYIIGCQDGLLATGGETLLQDIVRSRANYDLVLYVYNKVSDCVRPITVHIGPDGRLGCNVGYGFLHRIPTVKHCPQQAQQQGQDDNPVPVPVPVESETAFVPSAFTAPPVPTKKKSKNKKGTQPLAMDDYFNEGRDKSSTAAKSAESDILAPPPQKQSSSD
InterPro domains: - IPR024958: GRASP-type PDZ domain (domain) [66-281]
- IPR036034: PDZ superfamily (homologous_superfamily) [51-287]
- IPR007583: GRASP55/65 (family) [59-344]
Interaction partners: - Binder of USO1 and GRH1 protein 1
- Intracellular protein transport protein USO1
- GTP-binding protein YPT1
- Acyl-CoA-binding protein
- Protein transport protein SEC24
- Protein transport protein SEC23
- Cell cycle serine/threonine-protein kinase CDC5/MSD2
- GRIP domain-containing protein RUD3
- Integral membrane protein SED5
- SED5-binding protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0051649 (establishment of localization in cell), GO:0006914 (autophagy), GO:0046907 (intracellular transport), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0016236 (macroautophagy), GO:0016192 (vesicle-mediated transport), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000139 (Golgi membrane)
Protein: Metal transporter cnnm-5 (CNNM family homolog 5) (G5ED05)
Organism: Caenorhabditis elegans
Function: Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-4 to regulate Mg(2+) homeostasis.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MSLFLFAIFQLALGSPGAPNGPNVPLQLTGVRRGLDHVQKLPSEAFSFKLFGKNLAEDGYYFTTATRCEDSHLSTVSTVRATVKESYCSYAILSVPEGLPFNVSTSVYHLCHKNATIYTQKFLVVHEKKAAAAKYMGDEIVFCFFCILMSAYASGMTLGYMKFSMIDLNTMLKIAEGDAAKKRVRRIMHFRRRSTQLVVTFSLFSSVFTVLFTTTCEKMLHGVSNEDVLKMAVPALICLIFAEMIPQAVCNSKFGFNLAASLWFVTVIIFFVTLPIAYPASLVLGRFLKRDVREVMTPEEKTCLLRSMAQNEREKTILENATTFTLKKVGQLMVPIEEVFMLSRSQKLNRSTVLTLVEKGYTRIPVYDNKNRSVIVGMLNMKNFNLLMVKTNLIDEPTVKEALHALELLKDRTVKFAVKYVNIEMNAHLLLNRMKTGDFHFACVVEYSAYDSKVVGIITIEDILEKLIGKIDEINELRVRSSIDDRGDNAVIGWCREAGSDKKYPLPFSQQLRILQHLLSECQVLKSLDIGIMKAKQILSLDRIRVGKKNDKLELHDLLLVIFEGTVLVTNEVETFERVIDVPSQRSSSTVNSQQHRQQTTDNSRSTPVPVLIIGKPLLNRLMKSLGSPFSEPLGPKDNVSELVVVSEEASYFKLRLEDLMNSINGCRKVDRNGHTTTGESLLQTLNSRASTSTSTTPACRTPLSVDARSQDETTPFMEKQE
InterPro domains: - IPR044751: Ion transporter-like, CBS domain (domain) [328-465]
- IPR045095: Ancient conserved domain protein family (family) [137-582]
- IPR002550: CNNM, transmembrane domain (domain) [132-318]
- IPR046342: CBS domain superfamily (homologous_superfamily) [313-472]
- IPR000644: CBS domain (domain) [413-473]
Interaction partners: - Membrane Bound O-Acyl transferase, MBOAT
- non-specific serine/threonine protein kinase
- Probable GMP synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0051606 (detection of stimulus), GO:0042221 (response to chemical), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050877 (nervous system process), GO:0009593 (detection of chemical stimulus), GO:0007600 (sensory perception), GO:0050907 (detection of chemical stimulus involved in sensory perception), GO:0007606 (sensory perception of chemical stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)
Protein: Alpha/beta-Hydrolases superfamily protein (F4JBL2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MDSSQGSTQQKIVILNSHNENLVGLLHETGSTEIVVLCHGFRSNKNFEIMKNVAVAIEREGISAFRFDFSGNGYVFLSCIILNKLVFVLTLGLWCFHSFRESEGSFYYGNYNYEADDLHSVIQYFSNLNRVVTIILGHSKGGDVVLLYASKYHDIPNVINLSGRYDLKKGIGERLGEDFLERIKQQGYIDVKDGIVIALRFSCTVIRTLVLLSMYWFVTGDSGYRVTEESLMDRLNTDMHEACLKIDKECRVLTVHGSGDETVPVEDAKEFAKIIPNHELQIVEGADHCYTNYQSQLVLTVMEFIKSHCEEKNDKTCN
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [3-318]
- IPR022742: Serine aminopeptidase, S33 (domain) [33-163]
Interaction partners: - Prolyl endopeptidase
- Prolyl endopeptidase
- Dihydroorotase, mitochondrial
- Acylamino-acid-releasing enzyme
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Beta-1,3-galactosyltransferase bre-5 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 5) (Bt toxin-resistant protein 5) (Q95US5)
Organism: Caenorhabditis elegans
Function: Transfers N-acetylgalactosamine onto mannose groups of carbohydrate substrates. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3, and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.
Subcellular location: Golgi apparatus membrane {ECO:0000255, ECO:0000305}; Single-pass type II membrane protein {ECO:0000255, ECO:0000305}.
Sequence: MFLCVRILKRKYHELSSFQKLLIFTITIFLLWVLGVVDKFRETSFGDFSWPLETRNLQLRSKFTKYPQCKFSGNGQKIIIIIIKSSAKNGPMRESVRKTWGVFRMIDGVEVMPIFIVGRVENMEIMRRIDVESEKYKDILAISDIDSYRNNTLKLFGAIDYAANPNQCSSPDFTFLVDDDYLVHIPNLVKFAKTKQKEELVYEGFVFDTSPFRLKIHKHSISLNEYPFSRYPPYVSAGAVFLTSETIARFRNSIRKLKMFPFDDVFTGILAKTVNVAATHNENFIFWCRRVSQKEWDDGVIAVHGYARKDLEYEYSQLNGFE
InterPro domains: - IPR002659: Glycosyl transferase, family 31 (family) [55-287]
Interaction partners: - Beta-1,4-N-acetylgalactosaminyltransferase bre-4
- Beta-1,4-mannosyltransferase bre-3
- Galactoside 2-alpha-L-fucosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0008375 (acetylglucosaminyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0050794 (regulation of cellular process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0005975 (carbohydrate metabolic process), GO:0009966 (regulation of signal transduction), GO:1901576 (organic substance biosynthetic process), GO:0010646 (regulation of cell communication), GO:0009636 (response to toxic substance), GO:0045747 (positive regulation of Notch signaling pathway), GO:0008593 (regulation of Notch signaling pathway), GO:0016051 (carbohydrate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Synaptogyrin 3 (A0A8I6AUM8)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MSPFPTLSYGGRASGKDQGGGAGLRPWRMDLVGGAGSAPPRAPPPQPTRAPGRRRQRQQHPQHQQPQHQPWEVSGRAGRWDKRTEGTGPAMEGASFGAGRAGAAFDPVSFAQRPQTLLRVVSWVFSIAVFGPIVNEGYVNSDSGPELRCVFNGNAGACRFGVVLGLGAFIACVAFLLLDVRFQQISSVRDRRRAVLLDLGFSGVWSFLWFVGFCFLTNQWQRTAPGPGTAQAGDAARAAIAFSFFSILSWIWSWEASHGCRSQCVQTAVPAVWLCLAGVPAAH
InterPro domains: - IPR008253: Marvel domain (domain) [110-262]
- IPR016579: Synaptogyrin (family) [91-252]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0001505 (regulation of neurotransmitter levels), GO:0051049 (regulation of transport), GO:0051588 (regulation of neurotransmitter transport), GO:0051580 (regulation of neurotransmitter uptake)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0030672 (synaptic vesicle membrane), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0099501 (exocytic vesicle membrane), GO:0097708 (intracellular vesicle)
Protein: Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog) (Q9JLI7)
Organism: Mus musculus (Mouse)
Function: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10684790}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:10684790}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30535028}. Note=Associated with microtubules. Detected on the sperm flagellum (PubMed:10684790). Localizes in the cilium axoneme in a SPEF1-dependent manner (PubMed:30535028). {ECO:0000269|PubMed:10684790, ECO:0000269|PubMed:30535028}.
Sequence: MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRPLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKGDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALGYIARHNTELSQAVVDAGAIPLLVLCIQEPEIALKRIAASALSDISKHSPELAQTVVDAGAIAHLAQMILNPDAKLKRQVLSALSQIAKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNACTLIREIAKHTPELSQLIVNAGGVAAVIDCIGSCKGNIRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSICLSEEPEDHIKAAAAWALGQLGRHTPEHARAVAVTNTLPVLLSLYMSPESSEDLQLKSKKAIKNILQKCTYLPALEPFLYDAPPNILKHVVGQFSKVLPHDSKARRLFVTSGGLKKVQEIKAEPGSLLQEYINSINNCYPEEIVRYYSPGYSDTLLQRVDSYQPL
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [14-495]
- IPR011989: Armadillo-like helical (homologous_superfamily) [9-477]
- IPR000225: Armadillo (repeat) [30-365]
Interaction partners: - Sperm-associated antigen 17
- Sperm-associated antigen 16 protein
- Sperm flagellar protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0043073 (germ cell nucleus), GO:0001673 (male germ cell nucleus)