Protein: Adenylyl cyclase-associated protein 2 (CAP 2) (P40123)
Organism: Homo sapiens (Human)
Function: May have a regulatory bifunctional role.
Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Sequence: MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPIPEQFKTAWDGSKLITEPAEIMA
InterPro domains: - IPR053950: CAP, N-terminal domain (domain) [49-207]
- IPR036222: Adenylate cyclase-associated CAP, N-terminal domain superfamily (homologous_superfamily) [45-241]
- IPR036223: Adenylate cyclase-associated CAP, C-terminal superfamily (homologous_superfamily) [323-475]
- IPR013912: Adenylate cyclase-associated CAP, C-terminal (domain) [322-474]
- IPR018106: CAP, conserved site, N-terminal (conserved_site) [7-19]
- IPR006599: CARP motif (domain) [359-434]
- IPR016098: Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal (homologous_superfamily) [317-477]
- IPR017901: C-CAP/cofactor C-like domain (domain) [317-455]
- IPR013992: Adenylate cyclase-associated CAP, N-terminal (conserved_site) [6-34]
- IPR001837: Adenylate cyclase-associated CAP (family) [1-476]
- IPR028417: CAP, conserved site, C-terminal (conserved_site) [449-460]
Interaction partners: - Cofilin-1
- Twinfilin-2
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
- Drebrin
- Adenylyl cyclase-associated protein 1
- Glutaredoxin domain-containing cysteine-rich protein 1
- Drebrin-like protein
- Profilin-4
- Cofilin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0007163 (establishment or maintenance of cell polarity), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0043085 (positive regulation of catalytic activity), GO:0051339 (regulation of lyase activity), GO:0031279 (regulation of cyclase activity), GO:0045761 (regulation of adenylate cyclase activity), GO:0031281 (positive regulation of cyclase activity), GO:0051349 (positive regulation of lyase activity), GO:0045762 (positive regulation of adenylate cyclase activity), GO:0007190 (activation of adenylate cyclase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0030055 (cell-substrate junction), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0005925 (focal adhesion), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0005766 (primary lysosome)