wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Carboxy-S-adenosyl-L-methionine synthase (P76290)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)
Sequence: MSHRDTLFSAPIARLGDWTFDERVAEVFPDMIQRSVPGYSNIISMIGMLAERFVQPGTQVYDLGCSLGAATLSVRRNIHHDNCKIIAIDNSPAMIERCRRHIDAYKAPTPVDVIEGDIRDIAIENASMVVLNFTLQFLEPSERQALLDKIYQGLNPGGALVLSEKFSFEDAKVGELLFNMHHDFKRANGYSELEISQKRSMLENVMLTDSVETHKARLHNAGFEHSELWFQCFNFGSLVALKAEDAA
InterPro domains: - IPR041698: Methyltransferase domain 25 (domain) [60-158]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [18-247]
- IPR005271: Carboxy-S-adenosyl-L-methionine synthase (family) [1-243]
Interaction partners: - tRNA U34 carboxymethyltransferase
- tRNA 5-carboxymethoxyuridine methyltransferase
- Inner membrane protein YecN
- tRNA1(Val) (adenine(37)-N6)-methyltransferase
- tRNA (cytidine(34)-2'-O)-methyltransferase
- Thiazole synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0006400 (tRNA modification), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0002097 (tRNA wobble base modification), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing), GO:0002098 (tRNA wobble uridine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Cuticle collagen 38 (Q20754)
Organism: Caenorhabditis elegans
Function: Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle
Subcellular location: Nucleus
Sequence: MSKYLVPVCASISLVAVFGALVAMHSIVVDIDTMREEIVTGVHDMKVMSDDAWNRMIGFTKPSLDSESRSAAFASVFRNKRSAYPSQCNCDANSQGCPPGPPGPPGLPGGRGDQGPSGDKGRDGASGVSLAVTHHLPGGCIQCPQGPPGETGPDGDIGEPGFPGASGSAGQCGEDGAPGEAGITGEQGPQGEPGTEGSEGPTGQDGTIGGPGLPGQPGTPGWPGSQGEPGKNGDSGVDGEQGPQGPQGPDGQPGRDADNGQPGLPGKDGSIGPDANYCPCPARAKKH
InterPro domains: - IPR008160: Collagen triple helix repeat (repeat) [215-273]
- IPR002486: Nematode cuticle collagen, N-terminal (domain) [4-56]
Interaction partners: - Nematode cuticle collagen N-terminal domain-containing protein
- Cuticle collagen 49
- Nematode cuticle collagen N-terminal domain-containing protein
- Protein dao-4
- Cuticle collagen 71
- Nematode Specific Peptide family
- DUF229 domain-containing protein
- COLlagen
- Venom protein
- Major sperm protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0042302 (structural constituent of cuticle)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042303 (molting cycle), GO:0042335 (cuticle development), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle), GO:0042338 (cuticle development involved in collagen and cuticulin-based cuticle molting cycle), GO:0040002 (collagen and cuticulin-based cuticle development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0060102 (collagen and cuticulin-based cuticle extracellular matrix)
Protein: Cuticle collagen 49 (O44989)
Organism: Caenorhabditis elegans
Function: Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle
Sequence: MWKFVIGSVSTAAFFVSVCTIYFSVSMLDELDSFRLSIRDELEDWKEVSDDTWQRLNDMTSRNVPKKTNILKEFVRGKRNVGNDQCNCAEPTKNCPAGPPGEKGSLGNPGQPGPDGVDGDNGVDGDVVIHDMPNPKECIKCPAGPPGPPGPPGPLGPRGDKGPSGPRGALGDQGETGPVGEIGDQGPPGSAGRAGPRGQAGQPGTIAIVGLAGRPGPQGPLGEPGAQGEPGVDGKDGALGAPGRKAENGRPGKRGKDGVAGVPGTRGKEGEDAGYCTCPPRTA
InterPro domains: - IPR008160: Collagen triple helix repeat (repeat) [213-271]
- IPR002486: Nematode cuticle collagen, N-terminal (domain) [3-56]
Interaction partners: - Cuticle collagen 71
- Nematode cuticle collagen N-terminal domain-containing protein
- Cuticle collagen 38
- Protein dao-4
- CPG4 domain-containing protein
- Nematode cuticle collagen N-terminal domain-containing protein
- Nematode cuticle collagen N-terminal domain-containing protein
- COLlagen
- Venom protein
- Nematode Specific Peptide family
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0042302 (structural constituent of cuticle)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042303 (molting cycle), GO:0042335 (cuticle development), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle), GO:0042338 (cuticle development involved in collagen and cuticulin-based cuticle molting cycle), GO:0040002 (collagen and cuticulin-based cuticle development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0060102 (collagen and cuticulin-based cuticle extracellular matrix)
Protein: Cuticle collagen 71 (Q9N4U2)
Organism: Caenorhabditis elegans
Function: Probable cuticular collagen-like protein (Probable). Nematode cuticles are composed largely of collagen-like proteins (Probable). The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (Probable). Acts downstream of the Wnt signaling pathway, perhaps in the formation of the adult cuticle
Subcellular location: Membrane; Single-pass membrane protein. Nucleus
Sequence: MRNAGGDKPFSTPVLLREMGLKTHVDDDPKTKAYRLIGYAAVTFSTVSVICFCVTMPVVFTYVQSVKRQMSHEMATCNVNARQIFDDVAALRAGFPFAQAGNRTARQAGYDVHPSKPTPVGYSGGDAAAAEVKGNSPAAAYEDKPFVAVGVEEGPHTATTGSDSEGTCHDCCLPGPPGPPGPPGRPGPNGKAGANGLNGNPGRPPEAPCEPVTPPPCPPCPAGPKGAPGQAGYPGADGQPGSQGDNGEKGSDGAAGEKGRPGPLGKIGEPGATGETGENAENSEPTPGPQGPPGAIGPVGSRGTPGHPGEDGEAGAPGAPGENGTDGENGEDGVPGVPGHDGKAGRAGERGICPKYCAKDGGIFFEDGTRR
InterPro domains: - IPR008160: Collagen triple helix repeat (repeat) [223-281]
- IPR002486: Nematode cuticle collagen, N-terminal (domain) [36-88]
Interaction partners: - Cuticle collagen 49
- Nematode cuticle collagen N-terminal domain-containing protein
- Protein dao-4
- Cuticle collagen 38
- Prion-like-(Q/N-rich)-domain-bearing protein
- CPG4 domain-containing protein
- Nematode cuticle collagen N-terminal domain-containing protein
- Nematode Specific Peptide family
- Venom protein
- DUF229 domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042303 (molting cycle), GO:0042335 (cuticle development), GO:0018996 (molting cycle, collagen and cuticulin-based cuticle), GO:0042338 (cuticle development involved in collagen and cuticulin-based cuticle molting cycle), GO:0040002 (collagen and cuticulin-based cuticle development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0031594 (neuromuscular junction)
Protein: Sigma factor-binding protein Crl (P24251)
Organism: Escherichia coli (strain K12)
Function: Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes, such as the csgBAC operon encoding the subunits of curli proteins. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 (rpoD) and sigma-32 (rpoH)
Subcellular location: Cytoplasm
Sequence: MTLPSGHPKSRLIKKFTALGPYIREGKCKDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAGDWKSVPVKDTEVVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDEPVKLTA
InterPro domains: - IPR009986: Sigma factor-binding transcriptional regulator Crl (family) [1-128]
- IPR038208: Sigma factor-binding protein Crl superfamily (homologous_superfamily) [1-133]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0051540 (metal cluster binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0051536 (iron-sulfur cluster binding), GO:0051539 (4 iron, 4 sulfur cluster binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:2001057 (reactive nitrogen species metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046209 (nitric oxide metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006809 (nitric oxide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Cytokine response-modifying protein B (P0DSV7)
Organism: Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Function: Inhibits host immune defense by binding to host TNF and various chemokines in the extracellular space. Binds host CC chemokines (beta chemokines) and CXC chemokines (alpha chemokines)
Subcellular location: Secreted
Sequence: MKSVLYLYILFLSCIIINGRDAAPYTPPNGKCKDTEYKRHNLCCLSCPPGTYASRLCDSKTNTQCTPCGSGTFTSRNNHLPACLSCNGRCNSNQVETRSCNTTHNRICECSPGYYCLLKGSSGCKACVSQTKCGIGYGVSGHTSVGDVICSPCGFGTYSHTVSSADKCEPVPNNTFNYIDVEITLYPVNDTSCTRTTTTGLSESILTSELTITMNHTDCNPVFREEYFSVLNKVATSGFFTGENRYQNISKVCTLNFEIKCNNKGSSFKQLTKAKNDDGMMSHSETVTLAGDCLSSVDIYILYSNTNAQDYETDTISYRVGNVLDDDSHMPGSCNIHKPITNSKPTRFL
InterPro domains: - IPR001368: TNFR/NGFR cysteine-rich region (domain) [31-150]
- IPR011172: Poxvirus, TNF-alpha receptor-II (family) [5-338]
- IPR034059: Tumor necrosis factor receptor, N-terminal, viral (domain) [32-154]
- IPR051670: TNF and chemokine receptor-like (family) [22-201]
- IPR010806: Poxvirus, TNF receptor-II, C-terminal (domain) [172-313]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:1900047 (negative regulation of hemostasis), GO:0065008 (regulation of biological quality), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:1900046 (regulation of hemostasis), GO:0048585 (negative regulation of response to stimulus), GO:0050818 (regulation of coagulation), GO:0030195 (negative regulation of blood coagulation), GO:0032101 (regulation of response to external stimulus), GO:0030193 (regulation of blood coagulation), GO:0050878 (regulation of body fluid levels), GO:0050819 (negative regulation of coagulation), GO:1903035 (negative regulation of response to wounding), GO:0080134 (regulation of response to stress), GO:0032102 (negative regulation of response to external stimulus), GO:0061045 (negative regulation of wound healing), GO:1903034 (regulation of response to wounding), GO:0061041 (regulation of wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: C-reactive protein (Q0IIP8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine
Subcellular location: Secreted
Sequence: MLVVFLCLLSVTLEATEGFKNLSGKVLQFKTATDNSYVKLYPEKPLSLSAFTLCMRVATELPLDREVILFAYYTPDVDELNVWRERDGRVSLYIQSSKDAAFFRLPPLSTLQTHLCVAWESATGLTAFWMDGRRSLHQVYRKGYSIRSGGTVVLGQDPDSYVGSFDVDQSFVGEIANLQMWDYVLSSAQIKAVYYNQDNRVKGNVFDWDTIEYDVTGNVLVATDN
InterPro domains: - IPR001759: Pentraxin domain (domain) [19-225]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [21-222]
- IPR051005: Pentraxin domain-containing protein (family) [1-222]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)
Protein: Protein C19orf12 homolog (Q1L990)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Mitochondrion. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In response to oxidative stress, relocates to the cytosol forming aggregates that partially co-localize with mitochondria
Sequence: MPPHVDDVMKLCCELSANQQVKTAVKQSGKGAAAAGGLAFAGGLIGGPLGIAVGGAVGGLLGCWMKSGQFKPLPQVIMELTPDQQARLYEDIVAILGSITWTDVAQLTALVMGNASLQQQVTAALLSYIHKELQAEVHYID
InterPro domains: - IPR033369: Protein C19orf12 (family) [1-140]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0060429 (epithelium development), GO:0002064 (epithelial cell development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0030855 (epithelial cell differentiation), GO:0003158 (endothelium development), GO:0045446 (endothelial cell differentiation), GO:0001885 (endothelial cell development), GO:0061028 (establishment of endothelial barrier)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chondrosarcoma-associated gene 1 protein (Q6PB30)
Organism: Homo sapiens (Human)
Function: May play an important role in maintaining centrosome integrity during mitosis
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes at spindle poles and/or centrosomes in both mitotic and interphase cells. Spindle pole localization is more pronounced during mitosis. Centrosomal localization culminates at prophase
Sequence: MSATTACWPAFTVLGEARGDQVDWSRLYRDTGLVKMSRKPRASSPFSNNHPSTPKRFPRQPRREKGPVKEVPGTKGSP
Interaction partners: - Melanoma-associated antigen 12
- Melanoma-associated antigen 3
- Melanoma-associated antigen 6
- Melanoma-associated antigen F1
- Melanoma-associated antigen 1
- Neuronal PAS domain-containing protein 4
- Non-structural maintenance of chromosomes element 3 homolog
- Melanoma-associated antigen 2
- Melanoma-associated antigen D2
- MAGE-like protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0045786 (negative regulation of cell cycle), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0009416 (response to light stimulus), GO:0006974 (cellular response to DNA damage stimulus), GO:1901987 (regulation of cell cycle phase transition), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902807 (negative regulation of cell cycle G1/S phase transition), GO:0009411 (response to UV), GO:0000077 (DNA damage checkpoint signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (Q9H6J7)
Organism: Homo sapiens (Human)
Function: Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton. Note=Associated with microtubules
Sequence: MLSPERLALPDYEYLAQRHVLTYMEDAVCQLLENREDISQYGIARFFTEYFNSVCQGTHILFREFSFVQATPHNRVSFLRAFWRCFRTVGKNGDLLTMKEYHCLLQLLCPDFPLELTQKAARIVLMDDAMDCLMSFSDFLFAFQIQFYYSEFLDSVAAIYEDLLSGKNPNTVIVPTSSSGQHRQRPALGGAGTLEGVEASLFYQCLENLCDRHKYSCPPPALVKEALSNVQRLTFYGFLMALSKHRGINQALGALPDKGDLMHDPAMDEELERLLAQVPGLVNSVTASPEASCLPSRTPPRVGSPWRPLHHSRKVDGESDGSTEETDESET
InterPro domains: - IPR038968: Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (family) [1-331]
Interaction partners: - Leucine-rich repeat-containing protein 49
- Polyglutamylase complex subunit TTLL1
- Tubulin polyglutamylase complex subunit 2
- Nicolin-1
- Tubulin polyglutamylase complex subunit 1
- Eukaryotic translation initiation factor 3 subunit F
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0016192 (vesicle-mediated transport), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0007041 (lysosomal transport), GO:0016050 (vesicle organization), GO:0048284 (organelle fusion), GO:0061909 (autophagosome-lysosome fusion), GO:0061025 (membrane fusion), GO:0006906 (vesicle fusion), GO:1902774 (late endosome to lysosome transport), GO:0090174 (organelle membrane fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0034451 (centriolar satellite), GO:0043229 (intracellular organelle), GO:0005813 (centrosome), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)