wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: F-box only protein 33 (Q7Z6M2)
Organism: Homo sapiens (Human)
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity).
Sequence: MLLFLSVPQPRPPGARTRAGAARVARWRRLRLQQLRRLRGLLRVLRGRPGAGSRRRGRMALCGQAAGAASLPSELIVHIFSFLPAPDRLRASASCSHWRECLFYPALWPQLRICLRVSPAEQPRLEFLMRKCGWFVRELRVEFAAENYLSGGGPGDGGGADTGTGGEEVEALQLSARWLEVLRTYLELVLCVLVSIRNNRNLQKFSLFGDISVLQQQGSLSNTYLSKVDPDGKKIKQIQQLFEEILSNSRQLKWLSCGFMLEIVTPTSLSSLSNAVANTMEHLSLLDNNIPGNSTLITAVELERFVNLHSLALDFCDFTAEMARVLTDSNHVPLQRLSLLVHNVSVMHKSLDNMPNDEHWKALSRKSTSFRVYIMAFDIKSEDMLKILKPSIPLERIHFDSYITCVSGAIVDLISRQYDKFLTHFILMNDVIDTSGFPDLSDNRNEDPLVLLAWRCTKLSLLAIHGYTVWAHNLIAIARLRGSDLKVLEVTEESIDFDQGELADQDVDPVHNLIEQVSLGLGQPWHAVMDIESLSVFTEPNRHFYREMQSFSEDI
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [179-531]
- IPR001810: F-box domain (domain) [65-111]
- IPR036047: F-box-like domain superfamily (homologous_superfamily) [69-135]
Interaction partners: - Cullin-1
- Ribonuclease inhibitor
- S-phase kinase-associated protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0042752 (regulation of circadian rhythm), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)
Protein: Antitoxin MazE (P0C7B4)
Organism: Staphylococcus aureus (strain Newman)
Function: Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity.
Sequence: MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
InterPro domains: - IPR048242: Antitoxin MazE (family) [1-53]
- IPR013321: Arc-type ribbon-helix-helix (homologous_superfamily) [1-51]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019048 (modulation by virus of host process), GO:0048523 (negative regulation of cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0050794 (regulation of cellular process), GO:0051701 (biological process involved in interaction with host), GO:0031341 (regulation of cell killing), GO:0051709 (regulation of killing of cells of another organism), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0019054 (modulation by virus of host cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0044003 (modulation by symbiont of host process), GO:0039526 (modulation by virus of host apoptotic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0052041 (suppression by symbiont of host programmed cell death), GO:0052150 (modulation by symbiont of host apoptotic process), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0019050 (suppression by virus of host apoptotic process), GO:0033668 (suppression by symbiont of host apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Uncharacterized protein C63.14 (Q9Y7U0)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:10759889, ECO:0000269|PubMed:16823372}.
Sequence: MSTLGNSTVKPTNAEFPGLHAMERYKPATSESLYVKGHYGPHPHKEHPAAYVAAKTGFNATSRRQSVREHHSSHEGSAQLNPDRILYMSAGAVTAAVPNKEHTDNVTTSQTIRYETSSQPSQEVYHPHAGKAAQSAHVMNSTESRPSSAHVSSSYTQKPFAFPLGPVFATSSQAAASETALPSGYEPDEARFIGASQLAKLSASHAHQTPAQTVDDDVPLPTRMAATELVGHIPLRAANYANEYSQDVPASTHRAASELVHGVPMRASGINDPKHDLDAATRHNINSVAAASYVAARSRVIEEEEEPPNEVKERMDYEADAQRRIRKMNVFGSAGAALRERTQQDLMANEQEHSGEFAGFSRNLTNTAAAPTTYEYKRPTSSYTAKDATSKVYRSNTYKPKSSVNGSVYRSKSVKSTTSHNKVPERNSVPAYNEKLMHSSAANAAILSHKNYSPPVQPTRDDEVSQEDARVKEIVRGMKLPLTSSSLSAAAYRPMEKQDPATVERHHIQAEATQRVRDMKLDLTKLESKTNDEIRSYRPRNVVIKPYAAATPPKNIPSTYRAPQAPSVLSPVVTASEGDFELDGITPERQQTMTRSTYQESSQRPFHEDPFRTHPGLLQAVARNHRNSLANIDERIMRQNQAATANTNTVSETDIEALERRLSKAYRMEAQEEAYAINIGGGRVISPEELEEIARRNVDPMVSELSERAAQERERKEQAKEAKRLKKLAKEEKRLKKKEEKARKAEEKRLQKERAKYAKQMSRESAHADQAIANTGPVAPPYFEHETEPSHYEEEEEEEPEERREESSHFSESSGNNEFEETEQEYTHGYGNDVLVQRTDVVNNFGESSHAHDNAVNEKRDLGRNGFGDVDEQDATEVYRHSIERIVPGDYLHDEKTRDTLTRESPAFRSEEAVVEVADEDHPHASEAERAHSYSNRKQASSESSPESQSTHYNDYEGTEDNIVRQTTTVDEDGHQEQTTSTTKVAHPIPVSNGLSSPPRERLDDNAKEILSRSSPKSPVAWFKRKFKNRKDKAAVKRMLEEDSSKQLSSGRDVVAPTSVNHDVSHVGESTKPAVNNSTKPVAVTSKNGHSRNGSHAAHSNNVIGTQPHVNVSAVPNTGNLKDALEGSAVSKTDDVDNVVSGHSNVNGVSKSRPNIVERSEDYVISHLPEQSRAPIGAAFQEDL
InterPro domains: - IPR024527: Eisosome protein 1 (family) [1-1183]
Interaction partners: - Probable sphingolipid long chain base-responsive protein pil2
- Zinc metalloprotease mde10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0022607 (cellular component assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Mitochondrial inner membrane protease ATP23 (EC 3.4.24.-) (Q9SRP6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:28936218}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53722}; Intermembrane side {ECO:0000250|UniProtKB:P53722}. Note=Associates loosely with the inner membrane. {ECO:0000250|UniProtKB:P53722}.
Sequence: MEDAAAPNSGSEFNPGARRGKSIDECQDMIRRSFRNPIVKFLMEQMEKSGCRVGDNFVKAVVCTGPVAGGYTKGRGITVCSNYLTIQDEVNQVVIHELIHAYDECRAKNLDWTNCAHHACSEIRAGHLSGDCHFKRELLRGFIKLRGHEQECIKRRVLKSLRGNPYCSEVAAKDAMEAVWDTCYNDTKPFDRAP
InterPro domains: - IPR019165: Peptidase M76, ATP23 (family) [17-194]
Interaction partners: - Mitochondrial metalloendopeptidase OMA1
- Mitochondrial ATP-independent inner membrane protease subunit 1a
- Mitochondrial inner membrane protease subunit 2
- Mitochondrial ATP-independent inner membrane protease subunit 2
- Peptidase S24/S26A/S26B/S26C family protein
- Mitochondrial ATP-independent inner membrane protease subunit 1b
- Mitochondrial intermediate peptidase, mitochondrial
- Probable thylakoidal processing peptidase 2, chloroplastic
- Intermediate cleaving peptidase 55, mitochondrial
- Organellar oligopeptidase A, chloroplastic/mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006302 (double-strand break repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g) (Q6UXG3)
Organism: Homo sapiens (Human)
Function: Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q1ERP8}. Note=Transcytoses across the cytoplasm. {ECO:0000250|UniProtKB:Q1ERP8}.
Sequence: MRLLVLLWGCLLLPGYEALEGPEEISGFEGDTVSLQCTYREELRDHRKYWCRKGGILFSRCSGTIYAEEEGQETMKGRVSIRDSRQELSLIVTLWNLTLQDAGEYWCGVEKRGPDESLLISLFVFPGPCCPPSPSPTFQPLATTRLQPKAKAQQTQPPGLTSPGLYPAATTAKQGKTGAEAPPLPGTSQYGHERTSQYTGTSPHPATSPPAGSSRPPMQLDSTSAEDTSPALSSGSSKPRVSIPMVRILAPVLVLLSLLSAAGLIAFCSHLLLWRKEAQQATETQRNEKFCLSRLTAEEKEAPSQAPEGDVISMPPLHTSEEELGFSKFVSA
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [21-112]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [20-132]
- IPR050671: CD300 family immune receptors (family) [5-294]
- IPR007110: Immunoglobulin-like domain (domain) [14-121]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [15-131]
- IPR003599: Immunoglobulin domain subtype (domain) [22-125]
Interaction partners: - L-selectin
- Endomucin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0006909 (phagocytosis), GO:0043277 (apoptotic cell clearance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein PAT1 homolog 2 (AtPAT1H2) (Q94C98)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Activator of mRNA decapping. Involved in mRNA decay via decapping.
Sequence: MERSDSRDFYNFAKTSSDNNSALFDASQYEFFGQSLEEVELGGLDDDGTVRGHVDDEEYHLFDKREGAGLGSLSDMDDLATTFAKLNRNVTGPKHLGVIGDRGSGSFSRESSTATDWTQDNEFTSWLDQHTVEEQVQEASWSSQPQSSPNSNSLYRTSSYPQQQTQLQHYSSEPIIVPESTFTSFPSPGKRSQQSSPSHIHRAPSLPGGSQSNFSAPNASPLSNSTFHLSGLSHGPSHYGNNLARYASCGPTLGNMVQQPPHWVTDPGLLHGDHSALLHSLMQQQHLQQLPPRNGFTSQQLISLQQRQSLAHLAALQSQLYSSYPSPSHKALFGVGEVREHKHKSSHRSRKNRGGISQQTSDLASQKSESGLQFRSKYMTSEEIESILKMQHSNSHSSDPYVNDYYHQARLAKKSSGSRTKPQLYPSHLKDHQSRSRNSSDQQPQVHVDALGKITLPSICRPRALLEVDSPPSSGHKHLEDEPLVAARVTIEDAFGVLIDIVDIDRTLQFNRPQDGGAQLRRKRQILLEGLATSLQLVDPFSKTGQKTGLTTKDDIVFLRITTLPKGRKLLTKYLQLLVPGTEIARVVCMAVFRHLRFLFGGLPSDSLAAETIANLAKAVTVCVQAMDLRALSACLAAVVCSSEQPPLRPIGSSSGDGASVVLVSLLERAAEVIVAVVPPRVSNHGNPNDGLWRASFDEFFSLLTKYCRSKYETIHGQNHDNAADVLELAIKREMPAELLRASLRHTNEDQRNFLLNVGRSASPVSESTTTRASASGGQINSEFVRG
InterPro domains: - IPR039900: Pat1-like (family) [6-767]
Interaction partners: - Protein PAT1 homolog
- Protein PAT1 homolog 1
- Sm-like protein LSM3B
- Serine/threonine-protein kinase Nek4
- Sm-like protein LSM3A
- NOT2 / NOT3 / NOT5 family
- Probable NOT transcription complex subunit VIP2
- Varicose-related protein
- Anaphase-promoting complex subunit 5
- mRNA-decapping enzyme subunit 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0098727 (maintenance of cell number), GO:0019827 (stem cell population maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11) (P50539)
Organism: Homo sapiens (Human)
Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
Subcellular location: Nucleus.
Sequence: MERVKMINVQRLLEAAEFLERRERECEHGYASSFPSMPSPRLQHSKPPRRLSRAQKHSSGSSNTSTANRSTHNELEKNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [67-125]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [64-148]
Interaction partners: - Protein max
- Cell division cycle protein 20 homolog
- Anaphase-promoting complex subunit 4
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cell division cycle protein 27 homolog
- Myc proto-oncogene protein
- Paired amphipathic helix protein Sin3a
- Paired amphipathic helix protein Sin3b
- Forkhead box protein O3
- Double-strand-break repair protein rad21 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Small proline-rich protein 2F (O70557)
Organism: Mus musculus (Mouse)
Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MSYQEQQCKQPCQPPPVCPPPKCPEPCSPSVCPEPCPPPKCPEPCPEPCPPPSFQQKCPPVQPPPPCQQKCPPKSK
InterPro domains: - IPR029142: Small proline-rich protein 2 (family) [2-73]
Interaction partners: - Small proline-rich protein 2D
- Small proline-rich protein 2H
- Small proline-rich protein 2I
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005200 (structural constituent of cytoskeleton)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (FMO 1E1) (Hepatic flavin-containing monooxygenase 4) (FMO 4) (P36367)
Organism: Oryctolagus cuniculus (Rabbit)
Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Subcellular location: Microsome membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein {ECO:0000255}.
Sequence: MAKKVAVIGAGVSGLTSIKCCLDEDLEPTCFERSNDIGGLWKYTETSKDGMTRIYWSLVTNVCKEMSCYSDFPFQEDYPNFMSHSKFWNYLQEFAEHFDLLKYIQFKTTVCSVTKRPDFSKTGQWDVVTETEGKQHRAVFDAVMVCTGKFLNPRLPLESFPGILKFRGQILHCQEYKIPEGFRGQRVLVIGLGNSGGDVAVELSRVAAQVLLSTRTGTWVISRSSNGGYPFNMMITRRCLNVIEQVLPSCFLRWINERQMNKRFNHENYGLSITKGKNPKFIVNDELPTCILCGTVTVKTSVKEFTETSAIFEDGTVEENIDSVIFTTGYVFSFPFLEEPLRSLCMKKMFLYKHVFPSNLERASMAIIGLISLKGSILTGTELQARWATRVFKGLCKIPPPQQLMAEVTKKEELIKRGVIKDTSEEKLSYIPYMDDLAACIGTKPNIPLLFLKDPRLAWEVFFGPCTPYQYRLMGPGKWDGARNAILTQWDRTLKPLKTRTVSSDSSKSASLSHYLKVWGAPLLLASVLLICKSSHFLKSVRDKLQNRIFPYLVL
InterPro domains: - IPR020946: Flavin monooxygenase-like (family) [2-532]
- IPR050346: Flavin-containing monooxygenases-like (family) [3-506]
- IPR000960: Flavin monooxygenase FMO (family) [1-533]
- IPR002256: Flavin monooxygenase (FMO) 4 (family) [42-554]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [1-484]
Interaction partners: - medium-chain acyl-CoA ligase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0045333 (cellular respiration), GO:0009061 (anaerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)