Protein: Probable serine/threonine-protein kinase SIS8 (EC 2.7.11.1) (MAPKK kinase SIS8) (Protein SUGAR INSENSITIVE 8) (Q9C9U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Acts as negative regulator of salt tolerance. Mediates sugar response during early seedling development.
Subcellular location: Nucleus {ECO:0000269|PubMed:24320620}. Note=Colocalizes with UGT72E1 in the nucleus. {ECO:0000269|PubMed:24320620}.
Sequence: MKVKEETLKNLGDGVVLRPVDHCSSIWSMKMNMKNFLKKLHISPNQSDEAEGSISTTKSNHHKSIDVSSSSSPRSHHSNSPEIKPFSGLSNWLSSVGHRKIPSPPNSFNAKNRAATVDDTVVVNGSEHVDLGSKDPAVEEENQIQLALELSAREDPEATQIEAIKQFSLGSCAPENSPAELIAYRYWNYNCLGYDDKILDGFYDLYGVLNASSAERIPPLLDLQGTPVSDGVTWEAVLVNRSGDSNLLRLEQMALDIAAKSRSVSSSGFVNSELVRKLAILVGDYMGGPVVHPESMLRAWRSLSYSLKATLGSMVLPLGSLTIGLARHRALLFKVLCDSVGVPCRIVKGQQYTGSEDVAMNFIKADDGREYIVDLMGDPGTLIPADAAGLQIDYDESAYSASPGDNDSIHVASSSNGIESSYEENTEFRTGEHRSSTKSSGERNQSGGGGDLIVHPNISREDVKNQKKVEKAPFQNLSSRPIHSFTHMRSPSWTEGVSSPAAQRMKVKDVSQYMIDAAKENPRLAQKLHDVLLESGVVAPPNLFSEVYPQQLEATVESKNSTEAKKERGKDLETTQEGRHQNGFGPVRFLPPLPRVQSKTNAHDQRDNGKVVSQSDSSHSEASSTEYARTVPAAVAAAAVVASSMVAAAAAKSANSDSSPIELPAAAAATATAAAVVATAAAVSRQLELGSNSDGDDGSGGHEPQGSGDSNHGPNSGGERISDKSIGNESSKSDCDDVSDCEILWEEITVGERIGLGSYGEVYRGDWHGTEVAVKKFLDQDLTGEALEEFRSEVRIMKKLRHPNIVLFMGAVTRPPNLSIVTEFLPRGSLYRLIHRPNNQLDERRRLRMALDAARGMNYLHSCNPMIVHRDLKSPNLLVDKNWVVKVCDFGLSRMKHSTYLSSKSTAGTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTLQQPWGKMNPMQVVGAVGFQHRRLDIPDFVDPAIADLISKCWQTDSKLRPSFAEIMASLKRLQKPVTGSNIPRPVPSSSSLPTEHEQKD
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [738-1018]
- IPR055164: EDR1/CTR1/ARMC3-like, peptidase-like domain (domain) [179-383]
- IPR003903: Ubiquitin interacting motif (conserved_site) [139-158]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [867-879]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [748-1000]
- IPR017441: Protein kinase, ATP binding site (binding_site) [754-776]
- IPR000719: Protein kinase domain (domain) [748-1007]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [551-1005]
Interaction partners: - UDP-glycosyltransferase 72E1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004709 (MAP kinase kinase kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0006793 (phosphorus metabolic process), GO:0001101 (response to acid chemical), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0043207 (response to external biotic stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0098542 (defense response to other organism), GO:0019538 (protein metabolic process), GO:1901419 (regulation of response to alcohol), GO:0009966 (regulation of signal transduction), GO:0006796 (phosphate-containing compound metabolic process), GO:0032925 (regulation of activin receptor signaling pathway), GO:0023057 (negative regulation of signaling), GO:0043412 (macromolecule modification), GO:0009788 (negative regulation of abscisic acid-activated signaling pathway), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)