wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Oleate delta-12 desaturase (C8VTX5)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MSSTALPKRVALHRNPTTDSSVPSSVSVSPLDSPRQSPSSTSLSSMASDAGKGDLGKMLDTYGNEFKIPDYTIKDIRDAIPSHCYNRSAIRSLSYVFRDLAVLASVFYVFHKYVTPETVPSYPARVALWTLYTVVQGLFGTGIWVLAHECGHQAFSTSKVLNDTVGWILHSALLVPYFSWKISHGKHHKATGNLARDMVFVPKTREVYASRIKKTIYDLNEVMEETPLATATHSILQQLFGWPLYLLTNVTGHDNHERQPEGRGKGKRNGYFTGVNHFNPNSPLFEAKDAKLIILSDIGLAITASILYLIGSKFGWMNLLVWYGIPYLWVNHWLVAITYLQHTDPTLPHYQPESWTFARGAAATIDREFGFIGRHILHGIIETHVLHHYVSTIPFYHADEASEAIKKVMGSHYRSEAHTGPLGFLKALWTSARVCHWVEPTEGTKGENAGVLFFRNTNGIGVPPIKLTKPN
InterPro domains: - IPR012171: Fatty acid desaturase (family) [67-456]
- IPR005804: Fatty acid desaturase domain (domain) [128-417]
- IPR021863: Fatty acid desaturase, N-terminal (domain) [69-103]
Interaction partners: - Acyl-CoA desaturase
- Acyl-CoA desaturase
- Bifunctional oelate/linoleic acid delta desaturase
- Elongation of fatty acids protein
- Very-long-chain
- Very-long-chain 3-oxoacyl-CoA reductase
- very-long-chain enoyl-CoA reductase
- Elongation of fatty acids protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: PMS1 homolog 2, mismatch repair system component (D4A360)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MEPTEGASTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATSIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIREFADLTQVETFGFRGEALSSLCALSDVTISTCHVSASIGTRLVLDHNGKIIQKTPCPRPKGTTVSVQNLFYTLPVRHKEFQRNIKKEYAKMVQVLQAYCIISAGIRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLVPFVQLPPSDSVCEEYCLSACGTPQSPFRISGFISQCTHGAGRSSTDRQFFFINQRPCDPAKVSRLVNEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLMGMFDSDANKLSVNQQPLLNVEGNLVKLHTAEVGEQENSPSLRITAEEKRVASVSRLREAYSLHRTTETKSWGPETPELKQSFPSQKRGVSSSCPSDIISYRGLCGSQDKLVSPTDSPGDCMDREKGEKDSGLSSTSAGSEEGFSTPEVASSFSSDCNVSSPEDRPSQENTNCGEQFLEVDDHLSGTGHHLKPEDNGYKCRASLPPTRLSPSNAKRFRTEDRPSNVGVPQNTSAAEVDVAVKINKKIVLLDFSLSSLAKQMKQLQHLKQQSKSEHNYRKFRAKICPGENQAAEDELRREIRKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITWVHPSFRARSAPLQMKQLVPAAVCRHAYMWACIDTCTTHVHTFHIMIITAPLIESLLHGELLRECIHLIQVITPGSSCCHCCSQ
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [11-231]
- IPR014790: MutL, C-terminal, dimerisation (domain) [670-716]
- IPR037198: MutL, C-terminal domain superfamily (homologous_superfamily) [667-714]
- IPR014762: DNA mismatch repair, conserved site (conserved_site) [105-111]
- IPR014721: Small ribosomal subunit protein uS5 domain 2-type fold, subgroup (homologous_superfamily) [232-364]
- IPR042120: MutL, C-terminal domain, dimerisation subdomain (homologous_superfamily) [660-757]
- IPR038973: DNA mismatch repair protein MutL/Mlh/Pms-like (family) [14-785]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [209-364]
- IPR013507: DNA mismatch repair protein, S5 domain 2-like (domain) [227-364]
- IPR002099: DNA mismatch repair protein MutL/Mlh/PMS (family) [15-409]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0003697 (single-stranded DNA binding), GO:0004519 (endonuclease activity), GO:0030983 (mismatched DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009410 (response to xenobiotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (H2FLL7)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MVQTMSSRKVMVFVVTFVSYGLYHASRKALSGVKSSIKADWLSNSSGHAPLFTNEADAKHFLGSLDAIFMAAYAAALFFWGWLGDRLNPKLVVAAGMVGSAVTLTLFGAIPKWFNFYHAPYYIMTYVAFGLVQACGWPSEIAIMANWFGKGNRGFVMGVWAACQPVGNIFGSIFTAMVLPLGYQYTFVFNSVLIALGAIVVVMAIDSSPNEEHEDGVEANRIRLLRRSSSSEPHHNFHGEPISLFKAVLLPGVLAYCICNACLKLVNYAFFFWLPLYLTDAYHWEESQADQLSIWYDFGGIIGSVLGGYITDKMGKRSPLIVAMLVCSIGSLYFYAHVGPHMFWNAVVMTTVGVTVSGPYNLIVGSISIDLGSQPALAGNTQAMSTVSGLLDGTGSAGSAVGQLLIPIIQDDLGWKAVFYVFMLLNGFAILAILKRCIIDLKSLRKLRSGEESPLLNDEAGDHED
InterPro domains: - IPR011701: Major facilitator superfamily (family) [58-372]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [2-446]
- IPR000849: Sugar phosphate transporter (family) [1-453]
- IPR020846: Major facilitator superfamily domain (domain) [12-444]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0035435 (phosphate ion transmembrane transport), GO:0006817 (phosphate ion transport), GO:0015748 (organophosphate ester transport), GO:1901264 (carbohydrate derivative transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: LIM and cysteine-rich domains protein 1 (Dyxin) (Q9NZU5)
Organism: Homo sapiens (Human)
Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May shuttle between the cytoplasm and the nucleus. {ECO:0000250}.
Sequence: MAKVAKDLNPGVKKMSLGQLQSARGVACLGCKGTCSGFEPHSWRKICKSCKCSQEDHCLTSDLEDDRKIGRLLMDSKYSTLTARVKGGDGIRIYKRNRMIMTNPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGAFYRRRQLMHQLPIYDQDPSRCRGLLENELKLMEEFVKQYKSEALGVGEVALPGQGGLPKEEGKQQEKPEGAETTAATTNGSLSDPSKEVEYVCELCKGAAPPDSPVVYSDRAGYNKQWHPTCFVCAKCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFAEDYQRVEDLAWHRKHFVCEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS
InterPro domains: - IPR010442: PET domain (domain) [99-206]
- IPR033724: PET testin (domain) [116-203]
- IPR001781: Zinc finger, LIM-type (domain) [241-365]
- IPR047120: Prickle/Espinas/Testin (family) [21-363]
Interaction partners: - Transcription factor GATA-6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0043169 (cation binding), GO:0050839 (cell adhesion molecule binding), GO:0046872 (metal ion binding), GO:0003723 (RNA binding), GO:0045296 (cadherin binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030055 (cell-substrate junction), GO:0043231 (intracellular membrane-bounded organelle), GO:0005925 (focal adhesion), GO:0005634 (nucleus)
Protein: p300/CBP-associated factor (Q568Z2)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASVLEKFFFSKIKEAGLMDK
InterPro domains: - IPR001487: Bromodomain (domain) [1-81]
- IPR037800: Histone acetyltransferase GCN5 (family) [1-80]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [1-82]
Interaction partners: - Histone lysine acetyltransferase CREBBP
- histone acetyltransferase
- Transcriptional adapter 3
- Nuclear receptor coactivator
- Transcriptional adapter 2-alpha
- Nuclear receptor coactivator 2
- SAGA-associated factor 29
- Recombining binding protein suppressor of hairless
- Transcription initiation factor TFIID subunit 10
- Transcription initiation factor TFIID subunit 9B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Spectrin repeat containing nuclear envelope protein 1 (A0A5F9ZH86)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus membrane {ECO:0000256|ARBA:ARBA00004126}.
Sequence: XIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTVHKRWLRFLPF
InterPro domains: - IPR056887: Nesprin-1/2 domain (domain) [48-120]
- IPR018159: Spectrin/alpha-actinin (repeat) [242-461]
- IPR002017: Spectrin repeat (repeat) [241-348]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Protein OPG036 (Protein N2) (P14357)
Organism: Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Function: Plays a role in the inhibition of host innate immune response. Within the host nucleus, inhibits activation of interferon-beta promoter by inhibiting IRF3 activation.
Subcellular location: Host nucleus {ECO:0000269|PubMed:23761407}.
Sequence: MTSSAMDNNEPKVLEMVYDATILPEGSSMDPNIMDCINRHINMCIQRTYSSSIIAILDRFLMMNKDELNNTQCHIIKEFMTYEQMAIDHYGGYVNAILYQIRKRPNQHHTIDLFKRIKRTRYDTFKVDPVEFVKKVIGFVSILNKYKPVYSYVLYENVLYDEFKCFINYVETKYF
InterPro domains: - IPR022819: Poxvirus Bcl-2-like (family) [10-169]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019080 (viral gene expression), GO:0019083 (viral transcription), GO:0039695 (DNA-templated viral transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component)
Protein: Protein kinase, putative (Q586Q3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MAELLRKKIEALKSRKAAAEEPVVTPQSSSTTAALAPSSSLPSPSTTVTAAAPAQVKSTCSVPLANLPPAFVSPYTAVVKYRDTVKDPLCAQFTTSVAVELFKTFIQQRHRGNVSVQAQKRARSEDFGATERPVRSKEDNDSAKNEEEVQQQREEGYQHQHHNNSSGEGESLSGVGSGGDGINKNIVHFTHPPLCTVVSYFLPYLEARCFTHSDVKDREGKTTWASEAPDAPSLLQGYVTSLHKNVKSSVKAIRVSGKTRPPCRSVNEYVPVGQIAHGVYGVVYRATEANGSSSSGGGRGRKFALKQVKQRWLEESEVGFPPYLLREFDLLLRLRHPNIVCGREVVLLDKKSNSSKASKQQEVKPATGTTGREVSNEVGRHNHRTDNVQKTNEEPTASGNDDGLPSSCNQGGDKKEEEPPQIKTKLSADKMKDVYLVMEYCPYDLKAFIYHRKGVAALLHLSSANKHPDAPRCFLSRVKCVMQQLFTGVAFLHDHRILHRDIKTSNILISSTGEVKLCDFGLGRHYREGQELTANVVTLMYRAPELHFGITDYSYKMDMWSLGCIMAEIFLKEPLFRAEEESRHFAVICDVIGIPTEETFSGLYKMHEVTRLMRSLKRYNRENTLQQIFSRSNHSGAATLPPSGMDLLNRILRWNPIDRLSAREALEHKFFHEDPLPCMPEELLAPLPTTVAAEQMVGVPSQREGGAAVVAGKSSSETNCAIPQALESCEGGDNEETCGFGETVRSNAESPTADVLRARASNIDEEVEVEVRRR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [262-679]
- IPR050108: Cyclin-dependent kinase (family) [267-677]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [497-509]
- IPR000719: Protein kinase domain (domain) [269-671]
Interaction partners: - Cell division control protein, putative
- Cell-division control protein 2 homolog 6, putative
- cyclin-dependent kinase
- cyclin-dependent kinase
- cyclin-dependent kinase
- Protein kinase, putative
- Protein kinase, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Response regulator GacA (Global activator) (Q51373)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.
Sequence: MIKVLVVDDHDLVRTGITRMLADIEGLQVVGQADCGEDCLKLARELKPDVVLMDVKMPGIGGLEATRKLLRSQPDIKVVVVTVCEEDPFPTRLMQAGAAGYMTKGAGLEEMVQAIRQVFAGQRYISPQIAQQLALKSFQPQQHDSPFDSLSEREIQIALMIANCHKVQSISDKLCLSPKTVNTYRYRIFEKLSITSDVELALLAVRHGMVDAAS
InterPro domains: - IPR000792: Transcription regulator LuxR, C-terminal (domain) [143-208]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [2-119]
- IPR039420: Transcriptional regulatory protein WalR-like (family) [1-210]
- IPR011006: CheY-like superfamily (homologous_superfamily) [1-132]
- IPR016032: Signal transduction response regulator, C-terminal effector (homologous_superfamily) [132-211]
Interaction partners: - histidine kinase
- histidine kinase
- Sensory/regulatory protein RpfC
- histidine kinase
- cAMP-activated global transcriptional regulator Vfr
- HTH-type quorum-sensing regulator RhlR
- RNA polymerase sigma factor RpoS
- Transcriptional activator protein LasR
- UvrABC system protein C
- Translational regulator CsrA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)
Protein: Uncharacterized protein, isoform B (M9PF18)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
Sequence: MNKKDVSPSGSTVPATSVRTGFLRRRNVVEAGSEPSTSQQAEIAIASGKVKKRGILLARKDVEIESGVEVLEDMIPSTAVHIDHSKDVANKRAEEVTDAGADADSRASLTLPVAPGFSTLASSYVEKESGVRDTRSRISFFSNLSMLSVSQWREKHQGATAFALPVLLSVLLILLMILPVPDFLRGVFATLLFFTVMDCCGGHLRALLEDFMLTTHPERVAFAIPNYKFMPICEIPAVEEHKTIKTYAGWMNEINSYDPNTFSFSLTRAVYVRLDGSILKMSGTNARIPKRRMWNEPPIDRHKIPFTDHRSYDLRDCRIELLPLGLANKRFFNRKYPIQLIIKSNRDVPDEQSSVESQSEATVKTDAKEAKAASSSGTTPPGGEEEKLVDFAGTVMQADLQQLRNTVNPDKELNDITVPCGDEVRLLLFSRCDREKEDWYRRFTNASRGLVHEQDLQVPMARFVEDSDLQAAAARQALLLVTGMGKAGVKSEDEISAGKGNDETDQQTPDGQFETITEEDLLDTPKEESFDGMIMSANVARNSPDYVRFMAVYQACNQSTIPVTRSSVGTMRTTDRRPRKSRRAKRQEDELWKGIDQSLFLGPSGSIVWANVLLGRCLYSWLHDAMLHEKLKEVLQKKLNSIKLPSFMEEVIITNIYLGESPLLCHRVSQPMLDERGVWIDADVTYEGLAHITVTTKLNLLRIRSKTKSPMATDNVPTTSMLPEQSQDLRSLSEVNSENVIYDSDAESSGGSSTESESPPPGNAPENAAGTEFFQNSPGNARRIFKIVDRIAASNLFQYATELPYVQRAMENMNANITLRVDLKGLVARGTLNVPPPPSDRVWVSFRGPPRLWISTKPQVGDKSVDWSIVTNVIESKLCEAVNKFLVYPNMVDFSIPFLSNPNFDEDQGNAAN
InterPro domains: - IPR019411: MMM1 domain (domain) [605-665]
- IPR031468: Synaptotagmin-like mitochondrial-lipid-binding domain (domain) [603-897]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0022406 (membrane docking), GO:0071840 (cellular component organization or biogenesis), GO:0051640 (organelle localization), GO:0140056 (organelle localization by membrane tethering), GO:0016043 (cellular component organization), GO:1990456 (mitochondrion-endoplasmic reticulum membrane tethering)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system)