Protein: Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL) (O35678)
Organism: Mus musculus (Mouse)
Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18096503}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18096503}.
Sequence: MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [1-303]
- IPR022742: Serine aminopeptidase, S33 (domain) [40-275]
- IPR051044: Monoacylglycerol and Diacylglycerol Lipase (family) [24-293]
- IPR000073: Alpha/beta hydrolase fold-1 (domain) [69-245]
Interaction partners: - Patatin-like phospholipase domain-containing protein 2
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase 1 alpha subcomplex subunit 5
- NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
- Lipoprotein lipase
- NADH dehydrogenase iron-sulfur protein 2, mitochondrial
- NADH dehydrogenase iron-sulfur protein 4, mitochondrial
- Fatty-acid amide hydrolase 1
- Glycerol kinase
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0047372 (acylglycerol lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:0006629 (lipid metabolic process), GO:0044248 (cellular catabolic process), GO:0044057 (regulation of system process), GO:0044255 (cellular lipid metabolic process), GO:0045907 (positive regulation of vasoconstriction), GO:1901575 (organic substance catabolic process), GO:0003013 (circulatory system process), GO:0090066 (regulation of anatomical structure size), GO:0003018 (vascular process in circulatory system), GO:0046486 (glycerolipid metabolic process), GO:0008015 (blood circulation), GO:0006638 (neutral lipid metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:1903522 (regulation of blood circulation), GO:0035150 (regulation of tube size), GO:0097746 (blood vessel diameter maintenance), GO:0035296 (regulation of tube diameter), GO:0019229 (regulation of vasoconstriction), GO:0046461 (neutral lipid catabolic process), GO:0006639 (acylglycerol metabolic process), GO:0046503 (glycerolipid catabolic process), GO:0046464 (acylglycerol catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005811 (lipid droplet)