Protein: Fibroblast growth factor 20 (FGF-20) (Q9NP95)
Organism: Homo sapiens (Human)
Function: Neurotrophic factor that regulates central nervous development and function.
Subcellular location: Secreted {ECO:0000269|PubMed:11306498}.
Sequence: MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLMYT
InterPro domains: - IPR008996: Cytokine IL1/FGF (homologous_superfamily) [57-204]
- IPR002209: Fibroblast growth factor family (family) [36-196]
Interaction partners: - Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 4
- Klotho
- Pro-epidermal growth factor
- Fibroblast growth factor receptor 3
- Basement membrane-specific heparan sulfate proteoglycan core protein
- Fibroblast growth factor-binding protein 1
- Decorin
- Vascular endothelial growth factor receptor 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0003006 (developmental process involved in reproduction), GO:0007165 (signal transduction), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0048857 (neural nucleus development), GO:0030901 (midbrain development), GO:0008284 (positive regulation of cell population proliferation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0007420 (brain development), GO:0061458 (reproductive system development), GO:0007399 (nervous system development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0021762 (substantia nigra development), GO:0008406 (gonad development), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:0071774 (response to fibroblast growth factor), GO:0046546 (development of primary male sexual characteristics), GO:0007417 (central nervous system development), GO:0071363 (cellular response to growth factor stimulus), GO:0008584 (male gonad development), GO:1904705 (regulation of vascular associated smooth muscle cell proliferation), GO:1904707 (positive regulation of vascular associated smooth muscle cell proliferation), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0044344 (cellular response to fibroblast growth factor stimulus), GO:0008543 (fibroblast growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)