Protein: Nephrocystin-3 (Q6AZT7)
Organism: Xenopus laevis (African clawed frog)
Function: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
Subcellular location: Cell projection, cilium {ECO:0000250}.
Sequence: MGTASSLVNAGEVIEDTYGGGGGEDCVIPVEVKPKARLLRSSFRRGPRVIGASFKSTASVDLEYAAEYERLKKEYEIFRVSKNNEVASMQKKEIKLDEENKRLRAELQALQKTYQKILREKESAVEAKYQAMERAATFEHDRDKVKRQFKIFRETKEKEIQDLLRAKRDLEAKLQRLQAQGIQVFDPGESDSDDNGTEVTVPSTQCEYWTSGALGSDPSMGSMMQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDAAVASLLQVTPLFSQSLWSNTVRCYLMSTAETQAEVEIFLRDYSPKLQRMCETSGYFFQMVFFPEECESQHFAVRKWEIEKSSIVILFICSSLPSCLQEDCEEAFLKNNEAKPRLIYHSIEDGRSDSDGLKQLLEQDTNKANKTKVVDHCGDPVEGAYKLYCHLEQVIKQDLLGIEISDPDAKDESATMEDDDYGDVLWDVHDEQEQMEAYQQASQSICELGFQKYYDRLNDLVAAPAPIPPLLISGGPGSGKSLLLSKWIQLQQKHSPNTLMLYHFVGRPLSSSSEPSLIIKRLTLKLMQHSWSVSSLSMDPGKFLEEFPHWLEKLSIRYQGNIIIIIDSIDHIQQSEKHMKWLIDPLPVNVRVIVSVNVETCPQAWRLWPTLHLDPLNSKDVKALINMECGGANILLTKEQERKLERHCRSATTCNALYVTLITKLLTWAGSTGKIEDVLQQCLQCQDTVSLYRLVLRSVQEVMPSAKEKEFMREILCFISVSHNGVSECELMELCPGLTWEVLTSLIYHLYTLVLLKYTCGLLQFQHLQAWDAVNLEYMQGGQNIISEYREKIIKHFTTQLSHDRVTWRSADELTWLFQQQGEKQKLHKCLMNLFVSQNLYKRGHFAELLSYWQLVGKDKISMASEYFDALKQYEKNCEGEEKMTSLADLYETLGRFLKDLGLLSQAVTPLQRSLEIRETALDPDHPSVAQSLHQLAGVYMQSKKFGNAEQLYKQALEISENAYGSEHLRVARELDALAVLYQKQNKFEQAEQLRKKSLKIRQKSARRKGSMYGFALLRRRALQLEELTLGKDTSDNARTLNELGVLYYLQNNLETAETFLKRSLEMRERVLGADHPDCAQSINNLAALYNEKKQYDKAEELYERALDIRRRALSPDHPSLAYTVKHLAVLYKRKGKLDKAVPLYELAVDIRQKSFGPKHPSVATALVNLAVLYCQMKKQDDALPLYERAMKIYEDSLGRMHPRVGETLKNLAVLRYEEGDYEKAAELYKRAMEIKETETSVLGAKAPSGHSSSGGDTYSVQNTLPVSVFPE
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [868-1281]
- IPR056885: Nephrocystin-3, TPR-repeats region (domain) [818-1056]
- IPR056884: Nephrocystin 3-like, N-terminal (domain) [498-622]
- IPR056883: Nephrocystin 3, helical domain (domain) [647-806]
- IPR056886: Nephrocystin-3, alpha-beta domain (domain) [272-429]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [477-714]
- IPR019734: Tetratricopeptide repeat (repeat) [916-1269]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0035295 (tube development), GO:0035239 (tube morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070121 (Kupffer's vesicle development), GO:0009799 (specification of symmetry), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0050877 (nervous system process), GO:0072001 (renal system development), GO:0009855 (determination of bilateral symmetry), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0048562 (embryonic organ morphogenesis), GO:0072359 (circulatory system development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0001822 (kidney development), GO:0007600 (sensory perception), GO:0007507 (heart development), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0061371 (determination of heart left/right asymmetry), GO:0060026 (convergent extension), GO:0048793 (pronephros development), GO:0007368 (determination of left/right symmetry), GO:0050953 (sensory perception of light stimulus), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0003146 (heart jogging), GO:0007601 (visual perception), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0060271 (cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097546 (ciliary base), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)