Protein: HMG box-containing protein 1 (HMG box transcription factor 1) (High mobility group box transcription factor 1) (Q8R316)
Organism: Mus musculus (Mouse)
Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:15235594}.
Sequence: MVWEVKTNQMPNAVQKLLLVMDKRAPGMSDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSAIYQLSSDVSHQEYPRSSWSQNTSDIPENTHREDEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSGPAFPHDHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTIWHCFLKGTRLCFHKESNKEWQDVEDFARAASCDNEEEIQMGTHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGGPGTGQEFSGSEFSKSCGSPGSSQLSSSSLYAKAVKSHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
InterPro domains: - IPR039655: HMG box-containing protein 1 (family) [1-514]
- IPR003652: Ataxin, AXH domain (domain) [203-345]
- IPR009071: High mobility group box domain (domain) [435-505]
- IPR036096: Ataxin, AXH domain superfamily (homologous_superfamily) [202-339]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [420-505]
Interaction partners: - Paired amphipathic helix protein Sin3a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001217 (DNA-binding transcription repressor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0007389 (pattern specification process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0035556 (intracellular signal transduction), GO:0009611 (response to wounding), GO:0198738 (cell-cell signaling by wnt), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0060255 (regulation of macromolecule metabolic process), GO:0036342 (post-anal tail morphogenesis), GO:0031324 (negative regulation of cellular metabolic process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060322 (head development), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0030900 (forebrain development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0007166 (cell surface receptor signaling pathway), GO:0080090 (regulation of primary metabolic process), GO:0035239 (tube morphogenesis), GO:0060425 (lung morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0021915 (neural tube development), GO:0048562 (embryonic organ morphogenesis), GO:0016055 (Wnt signaling pathway), GO:0000165 (MAPK cascade), GO:0002009 (morphogenesis of an epithelium), GO:0016331 (morphogenesis of embryonic epithelium), GO:0010468 (regulation of gene expression), GO:0072175 (epithelial tube formation), GO:0007420 (brain development), GO:0042060 (wound healing), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0060606 (tube closure), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0009953 (dorsal/ventral pattern formation), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0001843 (neural tube closure), GO:0048706 (embryonic skeletal system development), GO:0001841 (neural tube formation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0014020 (primary neural tube formation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)