Protein: Probable manganese-transporting ATPase catp-8 (EC 7.2.2.-) (Cation transporting ATPase 8) (P90747)
Organism: Caenorhabditis elegans
Function: Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9HD20}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HD20}.
Sequence: MGVDQLVETIIPYNLRSIATHLYVPPFTIITAIWTYVWLNIFGYEEYYELGMLGYAAIFVILALVLLFCHWMMPVRCFLMCSKQEDVRIASHVCVIPTQNNGWPELVKLMRTTRDKQTKLWFEFQRVHYTWDEESREFQTKTLDTAKPMVFFQKSHGFEVEEHVKDAKYLLGDNKTEMIVPQFLEMFIERATAPFFVFQVFCVGLWCLEDMWYYSLFTLFMLMTFEATLVKQQMKNMSEIRNMGNKTYMINVLRGKKWQKIKIEELVAGDIVSIGRGAEEECVPCDLLLLRGPCIVDESMLTGESVPQMKEPIEDVEKDKIFDIETDSRLHVIFGGTKIVQHTAPGKAAEGMVKSPDGNCICYVIRTGFNTSQGKLLRTIMFGVKKATANNLETFCFILFLLIFAIAAAAYLWIKGSVDETRSKYKLFLECTLILTSVIPPELPIELSLAVNSSLMALQKLGIFCTEPFRIPFAGKVDICCFDKTGTLTTDNLVVEGVALNNQKEGMIRNAEDLPHESLQVLASCHSLVRFEEDLVGDPLEKACLSWCGWNLTKGDAVMPPKTAAKGISGIKIFHRYHFSSAMKRMTVVAGYQSPGTSDTTFIVAVKGAPEVLRNMYADLPSDYDETYTRLTRQGSRVLAMGIRKLGETRVGELRDKKRENFENDLAFAGFVVISCPLKSDTKTMIREIMDSSHVVAMITGDNPLTACHVSKVLKFTKKSLPTLVLDEPADGVDWMWKSVDGTIELPLKPETKNKMERKAFFNSHEFCLTGSAFHHLVHNEHTFLRELILHVKVFARMAPKQKERIINELKSLGKVTLMCGDGTNDVGALKHANVGVALLTNPYDAEKAAEKEKEKKAKIEEARSLVRSGAQLPQRPGAPGAPPAANAARRDAPPGARARAPLPPMANAAQARLDNLMKELEEEEKAQVIKLGDASIAAPFTSKYTSIASICHVIKQGRCTLVTTLQMFKILALNALVSAYSLSALYLDGVKFSDTQATIQGLLLAACFLFISKSKPLKTLSRQRPMANIFNAYTLLTVTLQFIVHFSCLLYIVGLAHEANTEKAPVDLEAKFTPNILNTTVYIISMALQVCTFAVNYRGRPFMESLFENKAMLYSIMFSGGAVFTLASGQATDLMIQFELVVLPEALRNALLMCVTADLVICYIIDRGLNFLLGDMF
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [249-379]
- IPR001757: P-type ATPase (family) [389-841]
- IPR057255: P5A-ATPase, transmembrane helical hairpin (domain) [16-84]
- IPR047820: P5A-type ATPase (family) [163-1113]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [487-681]
- IPR036412: HAD-like superfamily (homologous_superfamily) [476-850]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [462-961]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [483-489]
- IPR023214: HAD superfamily (homologous_superfamily) [671-853]
- IPR006544: P-type ATPase, subfamily V (family) [13-1169]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [170-1168]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0140358 (P-type transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)