Protein: Oxidized purine nucleoside triphosphate hydrolase (Q7ZWC3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy- dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress
Subcellular location: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus
Sequence: MFTSKLLTLVLVVQPGRVLLGMKKRGFGAGKWNGFGGKVQTGETIEQAARRELLEESGLTVDTLHKIGNIKFEFIGETELMDVHIFRADNYEGEPAESDEMRPQWFDIDKIPFSQMWADDILWFPLMLQKKRFLGYFKFQGHDVIVEHKLDEVEDL
InterPro domains: - IPR020084: NUDIX hydrolase, conserved site (conserved_site) [37-58]
- IPR003563: Oxidized purine nucleoside triphosphate (family) [4-154]
- IPR000086: NUDIX hydrolase domain (domain) [3-129]
- IPR020476: NUDIX hydrolase (domain) [32-61]
- IPR015797: NUDIX hydrolase-like domain superfamily (homologous_superfamily) [1-147]
Interaction partners: - 8-oxo-dGDP phosphatase NUDT18
- Nucleotide triphosphate diphosphatase NUDT15
- ADP-sugar pyrophosphatase
- m7GpppN-mRNA hydrolase NUDT17
- Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
- Uridine diphosphate glucose pyrophosphatase NUDT14
- Nudix (nucleoside diphosphate-linked moiety X)-type motif 22
- N-glycosylase/DNA lyase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0006979 (response to oxidative stress), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)