Protein: Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-related but catalytically inactive protein) (PRIP) (Q3USB7)
Organism: Mus musculus (Mouse)
Function: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as an inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors.
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MAEGAASREAPAPLDVAGGEDDPRAGADAASGDAPPPALGGRMRDRRSGVALPGAAGVPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFIEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMHLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGEKLYTEAPLSSESYLPSPEKLKNMIIVKGKKLPSESDLLEGEVTDEDEEAEMSRRMSGDYNGEQKHIWLCRELSDLVSICKSVQHRDFELSMKTQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLVLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCCEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKPQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGAIPDVQKRMLAAYDLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGGGSEAKGKRSLEAIEEKESSEENGKL
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [714-874]
- IPR001192: Phosphoinositide phospholipase C family (family) [110-849]
- IPR001849: Pleckstrin homology domain (domain) [110-226]
- IPR001711: Phospholipase C, phosphatidylinositol-specific, Y domain (domain) [586-702]
- IPR000008: C2 domain (domain) [702-831]
- IPR015359: Phosphoinositide-specific phospholipase C, EF-hand-like domain (domain) [311-392]
- IPR011992: EF-hand domain pair (homologous_superfamily) [239-397]
- IPR000909: Phosphatidylinositol-specific phospholipase C, X domain (domain) [399-544]
- IPR017946: PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily (homologous_superfamily) [396-713]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [107-229]
Interaction partners: - Gamma-aminobutyric acid receptor subunit gamma-2
- Gamma-aminobutyric acid receptor subunit gamma-1
- Gamma-aminobutyric acid receptor subunit alpha-1
- Gamma-aminobutyric acid receptor subunit alpha-6
- Gamma-aminobutyric acid receptor subunit alpha-2
- Gamma-aminobutyric acid receptor subunit epsilon
- Gamma-aminobutyric acid receptor subunit delta
- Gamma-aminobutyric acid receptor subunit alpha-5
- Gamma-aminobutyric acid receptor subunit alpha-3
- Gamma-aminobutyric acid receptor subunit beta-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0006955 (immune response), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0002252 (immune effector process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0044093 (positive regulation of molecular function), GO:0120161 (regulation of cold-induced thermogenesis), GO:0048468 (cell development), GO:0002366 (leukocyte activation involved in immune response), GO:0030154 (cell differentiation), GO:0009966 (regulation of signal transduction), GO:0051098 (regulation of binding), GO:0046649 (lymphocyte activation), GO:0050776 (regulation of immune response), GO:0070661 (leukocyte proliferation), GO:0007214 (gamma-aminobutyric acid signaling pathway), GO:0010646 (regulation of cell communication), GO:0002263 (cell activation involved in immune response), GO:0099177 (regulation of trans-synaptic signaling), GO:0050858 (negative regulation of antigen receptor-mediated signaling pathway), GO:0120163 (negative regulation of cold-induced thermogenesis), GO:0030097 (hemopoiesis), GO:0046651 (lymphocyte proliferation), GO:0002521 (leukocyte differentiation), GO:0050804 (modulation of chemical synaptic transmission), GO:0043393 (regulation of protein binding), GO:0032943 (mononuclear cell proliferation), GO:0030098 (lymphocyte differentiation), GO:0051099 (positive regulation of binding), GO:0050854 (regulation of antigen receptor-mediated signaling pathway), GO:0002285 (lymphocyte activation involved in immune response), GO:0042113 (B cell activation), GO:0050855 (regulation of B cell receptor signaling pathway), GO:0032092 (positive regulation of protein binding), GO:0042100 (B cell proliferation), GO:0032228 (regulation of synaptic transmission, GABAergic), GO:0002312 (B cell activation involved in immune response), GO:1903131 (mononuclear cell differentiation), GO:0030183 (B cell differentiation), GO:1900120 (regulation of receptor binding), GO:0002335 (mature B cell differentiation), GO:1900122 (positive regulation of receptor binding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)