Protein: Virulence protein SSD1 (Q5AK62)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Plays a role in resistance to host antimicrobial peptides such as protamine, RP-1, or human beta-defensin-2; allowing colonization of human tissues. Required for resistance to membrane permeabilization and maintenance of mitochondrial membrane potential upon exposure to RP-1
Sequence: MSSSQDYNNNSNNTPARVSSRKGKNLHVAHRRSPSELTNLMVEQYNLQRQLEEVQAQQKLLEEKQKQQQQQFTYPSAQGSSELAPPPISSGYGGNRSSHSRSSSINTHRRTGSGSGGTAHGHSRRHSLGLNEAIKAAANQKQSNRNSLSPTIPNEAKTDSSDDIGSFKFPPSGGDQGDTSGQSSSSHNRSRSLAYGQQSFKFPPTPDQSNDTRGNSLLPPNPNFSVTQSPDRGHNRRSSHFRTGSRGSGSNTNTDGINSNWRAQQQSPQQQQRQGGLLEPPQVGFTPGHKPRNSSYGGGSSVSSLQQFLPNNGGSNNSGQQGGHQGGGNNGRKTLFAPYLPQSSLPELINEGRLVTGTLRVNKKNRSDAYVSTDGLLDADIFICGSKDRNRALEGDLVAVELLIVDEVWESKKEKEEKKRRKDNTLHSRPLTDDIHNDATSAPNTAEGSVTGTSKEDGAGSNEEETGGLARRGSLKQRPTMKKNDDVEVEGQSLLLVEEEEINDEIKPLYAGHVVAVVDRIPGQLFAGTLGLLRPAQAAQAARDKKNGKESTVQNPKAPKIVWFKPTDKKVPLIAIPTEQAPKDFVENHEKYADRLFVASIKRWPITSLHPFGTLVSNLGPIDSPETEIDSILRDNNFLCDEYPDDDNDDIVSVNAYDLPSIEPEFENTQREEYLNDYIIAFTQNGEFVDHALHVKRISNTKIELGFHVADIAYFIKPGSSLDRKSKKRSSSVFLPQKTVNLFPKQVNKIVSFKENEKNLAVSVVFEIDTSNFEVEDLYIHESVIVPKQLVTYDAFDTILSGQSVDSISSATSDYVKTFSLIAKEFRRHRLSNRSLGITPNLTLLDQLDDEKVRLDLNIFKDSLAFDVISEISHKVNSAIAAKVHAGLGDQAILRRHPLPTLQKMETFVRKATSLGFKIDTTTSSTLQNSILKIDDPVKRKCVETLLYKCMSRGRYYVAGKQDTDSYAHYYFNLPLYTHFTAPLRRYADLIVHRQLKAVLNKQVEDKDLDSLKAITDYCNFKKDCAANAQEQAIHLLLSQTINEMSETAGQLLCMGTVVQVYESSFDVFIPEFGVEKRVHGDQLPLVKAEFDKNERILELWWEKGVDSATYIPPDEKSSLSYRNSIKNKYRTSALQAAKIQSKTALEKSTTPADSVAEKLAKLNLEPPKLVVPSLKSNELHEVEKDETKSMPSSPTQSEIPKNVRTNSSSRISSSGNTFSLEPYLQNTITRIEGDSYIQVIKELTQVPVLLRAEIGMALPCLTVRVLNPFAEEQ
InterPro domains: - IPR050180: RNR Ribonuclease (family) [32-1186]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [333-1127]
- IPR041505: Dis3-like cold-shock domain 2 (domain) [562-637]
- IPR041093: DIS3-like exonuclease 2-like, C-terminal (domain) [1050-1136]
- IPR001900: Ribonuclease II/R (domain) [671-1002]
Interaction partners: - Exosome non-catalytic core subunit
- Exosome non-catalytic core subunit
- Ribosomal RNA-processing protein 41
- Exosome non-catalytic core subunit
- Exosome non-catalytic core subunit
- Exosome non-catalytic core subunit
- Exosome non-catalytic core subunit
- Ribosomal RNA-processing protein 42
- Serine/threonine-protein kinase CBK1
- Ribosome dissociation factor GTPase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005488 (binding), GO:0030371 (translation repressor activity), GO:1901363 (heterocyclic compound binding), GO:0090079 (translation regulator activity, nucleic acid binding), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0000900 (mRNA regulatory element binding translation repressor activity), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0048027 (mRNA 5'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006349 (regulation of gene expression by genomic imprinting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0005935 (cellular bud neck), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010494 (cytoplasmic stress granule), GO:0000932 (P-body), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005634 (nucleus)