wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Innexin inx2 (Innexin-2) (G-Inx2) (Q9XYN1)
Organism: Schistocerca americana (American grasshopper)
Function: Structural components of the gap junctions.
Subcellular location: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction.
Sequence: MFDVFGSVKGLLKLDSVCIDNNLFRLHYKATVIILIAFSLLVTSRQYIGDPIDCIVDEIPLAVMDTYCWIYSTFTIPNRLNGKIGLEVAHPGVGAHVAGKDEVKYHKYYQWVCFVLFFQAILFYIPRYLWKTWEGGRIKMLVLDLNSPVVNEQSKADRKKLLVDYFATNLHTQNFYAYRFFICEALNFVNVVGQIYFMDLFLDGEFTTYGSDVVRFTEMEPEERSDPMSRVFPKVTKCTFHKYGPSGSVQTFDGLCVLPLNIVNEKIYVFLWFWFVILSVLTGIGLVYRLATAMGPQMRMYLLRARSRLAPQDQIETISNKCQIGDWFVLYQLGKNIDPLIYKELVADLAKKLEGKEIV
InterPro domains: - IPR000990: Innexin (family) [1-359]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015267 (channel activity), GO:0022829 (wide pore channel activity), GO:0005243 (gap junction channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007154 (cell communication), GO:0010644 (cell communication by electrical coupling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction), GO:0005921 (gap junction)
Protein: Uptake hydrogenase small subunit (EC 1.12.99.6) (Hydrogenlyase) (Membrane-bound hydrogenase small subunit) (P31892)
Organism: Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) (Ralstonia eutropha)
Function: This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions.
Subcellular location: Cell membrane; Peripheral membrane protein.
Sequence: MVETFYEVMRRQGISRRSFLKYCSLTATSLGLGPSFLPQIAHAMETKPRTPVLWLHGLECTCCSESFIRSAHPLAKDVVLSMISLDYDDTLMAAAGHQAEAILEEIMTKYKGNYILAVEGNPPLNQDGMSCIIGGRPFIEQLKYVAKDAKAIISWGSCASWGCVQAAKPNPTQATPVHKVITDKPIIKVPGCPPIAEVMTGVITYMLTFDRIPELDRQGRPKMFYSQRIHDKCYRRPHFDAGQFVEEWDDESARKGFCLYKMGCKGPTTYNACSTTRWNEGTSFPIQSGHGCIGCSEDGFWDKGSFYDRLTGISQFGVEANADKIGGTASVVVGAAVTAHAAASAIKRASKKNETSGSEH
InterPro domains: - IPR019546: Twin-arginine translocation pathway, signal sequence, bacterial/archaeal (conserved_site) [14-43]
- IPR027394: Cytochrome-c3 hydrogenase, C-terminal (domain) [225-306]
- IPR037024: [NiFe]-hydrogenase, small subunit, N-terminal domain superfamily (homologous_superfamily) [44-224]
- IPR001821: [NiFe]-hydrogenase, small subunit (family) [3-356]
- IPR006137: NADH:ubiquinone oxidoreductase-like, 20kDa subunit (domain) [60-205]
- IPR006311: Twin-arginine translocation pathway, signal sequence (conserved_site) [1-43]
- IPR037148: [NiFe]-hydrogenase, small subunit, C-terminal domain superfamily (homologous_superfamily) [227-337]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0051540 (metal cluster binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0051536 (iron-sulfur cluster binding), GO:0051539 (4 iron, 4 sulfur cluster binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0022900 (electron transport chain), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0019645 (anaerobic electron transport chain), GO:0009061 (anaerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0098552 (side of membrane), GO:1902494 (catalytic complex), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)
Protein: Sporulation-specific protease YabG (EC 3.4.-.-) (P37548)
Organism: Bacillus subtilis (strain 168)
Function: Cleaves the spore coat proteins SpoIVA and SafA. May cooperate with tgl to mediate the temperature-dependent cross-linking of coat proteins like GerQ.
Subcellular location: Forespore outer membrane {ECO:0000269|PubMed:10714992}. Note=Synthesized in the mother cell compartment and assembled on the surface of the forespore.
Sequence: MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRLIADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQEHYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDILVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFESLIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIETRGVLRIGMPYKSN
InterPro domains: - IPR008764: Peptidase U57, YabG (family) [2-290]
Interaction partners: - Uncharacterized protein YlbD
- Stage IV sporulation protein A
- Probable sporulation protein YtaF
- Protein YxeE
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009579 (thylakoid)
Protein: Coiled-coil-helix-coiled-coil-helix domain containing 6 (J3QTA6)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor {ECO:0000256|ARBA:ARBA00034476}.
Sequence: MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKVRPCLPPRFPRALGGRRGTSI
InterPro domains: - IPR042860: MICOS complex subunit MIC25 (family) [1-236]
- IPR007964: MICOS complex subunit MIC19/MIC25 (family) [31-189]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0016043 (cellular component organization), GO:0033554 (cellular response to stress), GO:0006996 (organelle organization), GO:0006974 (cellular response to DNA damage stimulus), GO:0061024 (membrane organization), GO:0007005 (mitochondrion organization), GO:0007006 (mitochondrial membrane organization), GO:0007007 (inner mitochondrial membrane organization), GO:0042407 (cristae formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0098799 (outer mitochondrial membrane protein complex), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0019867 (outer membrane), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0019866 (organelle inner membrane), GO:0031968 (organelle outer membrane), GO:0005742 (mitochondrial outer membrane translocase complex), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane), GO:0005743 (mitochondrial inner membrane), GO:0001401 (SAM complex)
Protein: Alpha/beta-Hydrolases superfamily protein (At1g18360/F15H18_2) (Q8VYJ0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MICSSKGTVVIATRSSFPRLLNRIQNRNDVPISVIATRRSSMSVEAFPMRLKSSQKKRKMNIGCGVSPSSPTTTVVDEEVAIRRKLAMRRVLEDNGGDGSSVRDFSLFTTKRGDTLFTQSWTPVDSAKNRGLVVLLHGLNEHSGRYSDFAKQLNVNGFKVYGIDWIGHGGSDGLHAYVPSLDYAVADLKSFIEKVIAENPGLPCFCIGHSTGGAIILKAMLDAKIEARVSGIVLTSPAVGVQPTYPIFGVIAPFLSFLIPRYQLSAAKKKIMPVSRDPEALLAKYSDPLVYTGFIRARTGNEILRLGAHLLQNLNRIKVPFLVMHGTADTVTDPKGTQKLYNEASSSDKSIKLYDGLLHDLLFEPERETIAGVILDWLNRRV
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [98-382]
- IPR022742: Serine aminopeptidase, S33 (domain) [128-366]
- IPR051044: Monoacylglycerol and Diacylglycerol Lipase (family) [110-381]
Interaction partners: - Triacylglycerol lipase SDP1L
- Triacylglycerol lipase SDP1
- Alpha/beta-Hydrolases superfamily protein
- Alpha/beta-Hydrolases superfamily protein
- Glycerol kinase
- Aldo-keto reductase family 4 member C10
- 
- Non-specific phospholipase C3
- 
- RHOMBOID-like protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0047372 (acylglycerol lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0006638 (neutral lipid metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0006639 (acylglycerol metabolic process), GO:0006641 (triglyceride metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 1H-pyrrole-2-carbonyl-[peptidyl-carrier protein] chlorinase (EC 1.14.19.56) (FADH2-dependent halogenase PltA) (Q4KCZ0)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Function: Involved in the biosynthesis of the antibiotic pyoluteorin. Catalyzes the dichlorination of the pyrrole ring of pyrrolyl-S-PltL, generating the 5-chloropyrrolyl-S-PltL intermediate and then the 4,5-dichloropyrrolyl-S-PltL product.
Sequence: MSDHDYDVVIIGGGPAGSTMASYLAKAGVKCAVFEKELFEREHVGESLVPATTPVLLEIGVMEKIEKANFPKKFGAAWTSADSGPEDKMGFQGLDHDFRSAEILFNERKQEGVDRDFTFHVDRGKFDRILLEHAGSLGAKVFQGVEIADVEFLSPGNVIVNAKLGKRSVEIKAKMVVDASGRNVLLGRRLGLREKDPVFNQFAIHSWFDNFDRKSATQSPDKVDYIFIHFLPMTNTWVWQIPITETITSVGVVTQKQNYTNSDLTYEEFFWEAVKTRENLHDALKASEQVRPFKKEADYSYGMKEVCGDSFVLIGDAARFVDPIFSSGVSVALNSARIASGDIIEAVKNNDFSKSSFTHYEGMIRNGIKNWYEFITLYYRLNILFTAFVQDPRYRLDILQLLQGDVYSGKRLEVLDKMREIIAAVESDPEHLWHKYLGDMQVPTAKPAF
InterPro domains: - IPR050816: Flavin-dependent Halogenases in Natural Product Biosynthesis (family) [3-379]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [1-449]
- IPR002938: FAD-binding domain (domain) [5-337]
Interaction partners: - Peptidyl carrier protein PltL
- Polyketide synthase PltB
- Polyketide synthase PltC
- Putative halogenase PltD
- Putative acyl carrier protein
- L-proline--[L-prolyl-carrier protein] ligase
- L-prolyl-[peptidyl-carrier protein] dehydrogenase
- Lipid A biosynthesis
- Thioesterase PltG
- AMP-binding domain protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0019748 (secondary metabolic process), GO:0044550 (secondary metabolite biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Heat shock protein sti1 homolog (Q9USI5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May play a role in mediating the heat shock response of some HSP70 genes.
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MAEELKAKGNAAFSKKDYKTAIDYFTQAIGLDERNHILYSNRSACYASEKDYADALKDATKCTELKPDWAKGWSRKGAALHGLGDLDAARSAYEEGLKHDANNAQLLNGLKSVEAAQTQAASGAGGFNPFAKLGSQLSDPKFMEKLASNPETASLLADSAFMAKLQKIQQNPGSIMAELNDPRMMKVIGMLMGIDINMNAGEGAAEEQEKKEEFAPSSSTPSADSAKPETTNPPPQPQASEPMEEDKTAEELEEAATKEALKKKADQEKQIGNENYKKRNFPVAIEQYKKAWDTYKDITYLNNLAAAYFEADQLDDCIKTCEDAIEQGRELRADFKLIAKALGRLGTTYQKRGDLVKAIDYYQRSLTEHRTPDILSRLKDAEKSKELQDREAYIDPDKAEESRVKGNELFKSGDFANAIKEYTEMTKRAPSDPRGFGNRAAAYLKVMAPAECIRDCNKAIELDPNFAKAYVRKAQALFMLKDYNKCIDACNEASEVDRREPNTGKNLREIESQLSKCMSAMASQRQNETEEETMARIQKDPEVLGILQDPAMQAILGQARENPAALMEHMKNPTVKSKIEKLIASGVIRLG
InterPro domains: - IPR041243: STI1/HOP, DP domain (domain) [139-583]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1-521]
- IPR019734: Tetratricopeptide repeat (repeat) [2-500]
- IPR006636: Heat shock chaperonin-binding (domain) [139-569]
Interaction partners: - Heat shock protein 90 homolog
- Uncharacterized protein C1711.08
- Heat shock protein homolog pss1
- Heat shock protein 104
- 40 kDa peptidyl-prolyl cis-trans isomerase
- Probable heat shock protein ssa2
- Hsp90 co-chaperone Cdc37
- Probable heat shock protein ssa1
- Heat shock protein 78
- Protein psi1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0031072 (heat shock protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0035966 (response to topologically incorrect protein), GO:0035967 (cellular response to topologically incorrect protein), GO:0006986 (response to unfolded protein), GO:0071310 (cellular response to organic substance), GO:0034605 (cellular response to heat), GO:0034620 (cellular response to unfolded protein)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Uncharacterized WD repeat-containing protein C2A9.03 (Q9Y7K5)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Sequence: MSNGEFIDQYLLPESGAILQDYLDDYFYTSWYTGNRNLIQLDHYGFPTASNFELNPKSTDNCGTVDFQGIPWGNKAIGKRKNFRLYRLHTYSLSCNHSDWSPEELSLDTVQVAAEDSFYEFQRFLKNPNCLRNHHHLCKSVKVVGEHSVIYVSNNSIRMENTLHDNSVQIIDLKNNILQKKAISCLDTTNAVGCLGTLYGQYCIFNFKNGSFSTRKLSDDSINHIQLFSEKKFILGCNDGAVYVEDVQRTSPILVYRCSNAVNCVQLFDETPLALVCTDSKDAMLIDIRSNSVSAKLPHSDSVLTGSWHPNGNILATGGQDTTAKVWDIRALGKSFRNLGSQMSAVTNLCFSPLGESLAVTEQADFVQLFDTKLFNTSQVIDFFGEIAGTAYSSSGDSLFIGVDDPMLGGILEFRRPLQHPLSFIF
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [82-411]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [132-408]
- IPR001680: WD40 repeat (repeat) [249-371]
- IPR019775: WD40 repeat, conserved site (conserved_site) [315-329]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.-) (Q94F26)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MDSSSNLNPLREDTSEEHLEPIEAPASVFAARPLRPPSTNSSEKYSPVEWKSYFDKEDDISITGSDDVFHVYMAGNEGPVVFCLHGGGYSGLSFSIVASKIKEKARVVAMDLRGHGKSVSENELELSLETMSNDVLAVIKELYGDSPPAIVLVGHSMGGSVAVQVAANKTLPSLAGLVVVDVVEGTAISSLIHMQKILSNRMQHFPSIEKAIEYSVRGGSLRNIDSARVSIPTTLKYDDSKHCYVYRTRLEETEQYWKGWYDGLSEKFLSSPVPKLLLLAGTDRLDRTLTIGQMQGKFQMIVVKHTGHAIQEDVPEEFANLVLNFISRNRIGPHGVEIPGMWKPSQQTKT
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [43-334]
- IPR000073: Alpha/beta hydrolase fold-1 (domain) [81-320]
- IPR016812: Protein phosphatase methylesterase, eukaryotic (family) [1-349]
Interaction partners: - Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
- Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
- Serine/threonine-protein phosphatase 2A activator
- WW domain-containing protein
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0052689 (carboxylic ester hydrolase activity), GO:0047372 (acylglycerol lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006629 (lipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006796 (phosphate-containing compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: AFG2 interacting ribosome maturation factor (V9GYQ8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MTQDRPLLAVQEALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVPALRAFPDLKERLRRKQLVAGDIVLDKLGERLAILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQWGDLANIQALPKAWDRISKDEHQDLVQ
InterPro domains: - IPR029159: Ribosome biogenesis protein C1orf109-like (family) [1-191]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042273 (ribosomal large subunit biogenesis), GO:0042254 (ribosome biogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)