Protein: Ras-related protein Rab-3B (EC 3.6.5.2) (P20337)
Organism: Homo sapiens (Human)
Function: Protein transport. Probably involved in vesicular traffic (By similarity).
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9CZT8}. Note=Colocalizes with GAS8/DRC4 in the Golgi apparatus. {ECO:0000250|UniProtKB:Q9CZT8}.
Sequence: MASVTDGKTGVKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGQLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSMLGSSKNTRLSDTPPLLQQNCSC
InterPro domains: - IPR005225: Small GTP-binding domain (domain) [21-177]
- IPR037872: Rab3 (family) [22-186]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4-192]
- IPR050305: Small GTPase superfamily, Rab (family) [16-212]
- IPR001806: Small GTPase (family) [15-213]
Interaction partners: - Polymeric immunoglobulin receptor
- Rab15 effector protein
- Rabphilin-3A
- Ras-related protein Rab-3A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0008092 (cytoskeletal protein binding), GO:0017022 (myosin binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0031489 (myosin V binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0019882 (antigen processing and presentation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098793 (presynapse), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043230 (extracellular organelle), GO:0030133 (transport vesicle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0070382 (exocytic vesicle), GO:0065010 (extracellular membrane-bounded organelle), GO:0030667 (secretory granule membrane), GO:0030135 (coated vesicle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0030665 (clathrin-coated vesicle membrane)