Protein: Endothelial transcription factor GATA-2a isoform X1 (A0A8M3AXB8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Nucleus
Sequence: MEVAADQSRWMAHHHAVLNGQHPESHHHGLTHNYMEPMAPLLPPDEVDVFLNHLDSQGNPYYSNSRARVSYGQAHARLTGSQVCRPHLIHSPGIPWLDSGKAALSAAHHNAWAVSHFSKPGLHPASAAYPCSSSSSTAPVSSLTSATHSSPHPLYNFPPTPPKDVSPDPGPSSPTSTTARMDEKESIKYQVSIADGMKMEGCSPLRGSLAMSAQTPSTHHPIPTYPTYSLPAPHDYGGGLFHPGTLLSGSASSFTPKCKSKTRSCSEFCTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNGNGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKRSKRSGEGFEELSKCMQDKTSPFGSASALASHMPHMGHLPPFSHSGHMLPTPTPIHPTFSHPHHSGRSPAWAEPH
InterPro domains: - IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [269-382]
- IPR016374: Transcription factor, GATA-2/3 (family) [1-457]
- IPR039355: Transcription factor GATA (family) [14-448]
- IPR000679: Zinc finger, GATA-type (domain) [269-377]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0002262 (myeloid cell homeostasis), GO:0035295 (tube development), GO:0034101 (erythrocyte homeostasis), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0009790 (embryo development), GO:0003188 (heart valve formation), GO:0003170 (heart valve development), GO:0003179 (heart valve morphogenesis), GO:0048872 (homeostasis of number of cells), GO:0035239 (tube morphogenesis), GO:0030097 (hemopoiesis), GO:0021510 (spinal cord development), GO:0003171 (atrioventricular valve development), GO:0022008 (neurogenesis), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0030218 (erythrocyte differentiation), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0021514 (ventral spinal cord interneuron differentiation), GO:0007417 (central nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030099 (myeloid cell differentiation), GO:0030182 (neuron differentiation), GO:0003181 (atrioventricular valve morphogenesis), GO:0007507 (heart development), GO:0060840 (artery development), GO:0061515 (myeloid cell development), GO:0035904 (aorta development), GO:0048821 (erythrocyte development), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0048844 (artery morphogenesis), GO:0035162 (embryonic hemopoiesis), GO:0035909 (aorta morphogenesis), GO:0035907 (dorsal aorta development), GO:0060215 (primitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)