Protein: Sporulation-regulated protein 28 (Q04921)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Septins are GTPases involved in cytokinesis that assemble into filaments and form a ring at the cleavage site. May act by recruiting MYO1 and HOF1, a protein involved in septation, to the site of cleavage. Septins are also involved in cell morphogenesis, bud site selection, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Bud neck {ECO:0000250}. Note=Present at the bud neck during cell division. Probably interacts with phosphoinosides such as phosphatidylinositol 4-phosphate or phosphatidylinositol 5-phosphate (By similarity). Localizes to ring-like structures around each of the four nuclear lobes at the onset and during meiosis II. Concentrated initially at the leading edge of the developing prospore wall. {ECO:0000250, ECO:0000269|PubMed:8885406}.
Sequence: MFPMKDHSALEQHTLSRDELRRRKGYKKGLQLSILLLGEKGSGKSTFLNNLCGQDISLSDGDYDDDDDKVTNNVTPENGNAIEDIDPGYKTAHLSPGLKLVTRRVYLNDELGVPITLDIILFPGCGDNVDNSQSSVVIKNYLDQQFANVLKEEVRIKRNTKETDGRPHVCLYFLKSTPRGVKKFDIELMKTICDKVNLIPIIPKADGLTETELNLHKDIVRQEISQNNIRVFDFKSDTLGETLALYDMDIDSSSAKSKYDNDTKIKEISPFAIVCSKTFNKNSENRVEHIRTYEWGSLVVEDQNTSDFIYLKAILLGSHLQELKDVTNNVLYENYRAKVLTEKKNNYDIPNYSYIDETSRGSVSNVSTRRNSASRTLGNPDTNDENAYQIHKEIDEKNRIIEDYQRKIDLLEKMLAAPHQNKV
InterPro domains: - IPR016491: Septin (family) [3-422]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [17-341]
- IPR030379: Septin-type guanine nucleotide-binding (G) domain (domain) [28-346]
Interaction partners: - Cell division control protein 11
- Sporulation-regulated protein 3
- Cell division control protein 10
- Cell division control protein 3
- Cell division control protein 12
- GTPase-GDP dissociation stimulator BEM4
- Spore-specific protein YSW1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005198 (structural molecule activity), GO:0060090 (molecular adaptor activity), GO:0005200 (structural constituent of cytoskeleton), GO:0016787 (hydrolase activity), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0005543 (phospholipid binding), GO:0035091 (phosphatidylinositol binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0005545 (1-phosphatidylinositol binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0010314 (phosphatidylinositol-5-phosphate binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0070273 (phosphatidylinositol-4-phosphate binding), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0007163 (establishment or maintenance of cell polarity), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0000910 (cytokinesis), GO:0044093 (positive regulation of molecular function), GO:1903047 (mitotic cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0000278 (mitotic cell cycle), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0051247 (positive regulation of protein metabolic process), GO:0008104 (protein localization), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0000281 (mitotic cytokinesis), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0043549 (regulation of kinase activity), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0045860 (positive regulation of protein kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0032161 (cleavage apparatus septin structure), GO:0031105 (septin complex), GO:0032153 (cell division site), GO:0000399 (cellular bud neck septin structure), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0042763 (intracellular immature spore), GO:0051286 (cell tip), GO:1990234 (transferase complex), GO:0120025 (plasma membrane bounded cell projection), GO:0042764 (ascospore-type prospore), GO:0043332 (mating projection tip), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0005628 (prospore membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005935 (cellular bud neck), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0005937 (mating projection), GO:0005940 (septin ring), GO:1902911 (protein kinase complex), GO:0005856 (cytoskeleton), GO:0032156 (septin cytoskeleton), GO:1902554 (serine/threonine protein kinase complex)