Protein: Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (ETTh) (Organic cation/carnitine transporter 1) (OCTN1) (Q9H015)
Organism: Homo sapiens (Human)
Function: Sodium-ion dependent transporter of various organic cationic compounds. A key substrate of this transporter is ergothioneine (ET). Able to transport carnitine, probably moving one sodium ion with one molecule of carnitine. Also transports tetraethylammonium (TEA) without the involvement of sodium. May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:20601551}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:16729965}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of small intestines (PubMed:20601551). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:20601551, ECO:0000269|PubMed:35307651}.
Sequence: MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [113-523]
- IPR045915: Solute carrier family 22 members 4/5 (family) [106-508]
- IPR020846: Major facilitator superfamily domain (domain) [88-512]
- IPR005829: Sugar transporter, conserved site (conserved_site) [160-176]
- IPR004749: Organic cation transport protein/SVOP (family) [12-518]
- IPR005828: Major facilitator, sugar transporter-like (family) [141-517]
Interaction partners: - Nucleotide-binding oligomerization domain-containing protein 2
- Runt-related transcription factor 1
- Protein-arginine deiminase type-4
- Multidrug and toxin extrusion protein 1
- Multidrug and toxin extrusion protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015101 (organic cation transmembrane transporter activity), GO:0019904 (protein domain specific binding), GO:0042910 (xenobiotic transmembrane transporter activity), GO:0072349 (modified amino acid transmembrane transporter activity), GO:0015651 (quaternary ammonium group transmembrane transporter activity), GO:0015226 (carnitine transmembrane transporter activity), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046415 (urate metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0072521 (purine-containing compound metabolic process), GO:0015695 (organic cation transport), GO:0015697 (quaternary ammonium group transport), GO:0072337 (modified amino acid transport), GO:0015838 (amino-acid betaine transport), GO:0015879 (carnitine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0098862 (cluster of actin-based cell projections), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005783 (endoplasmic reticulum), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0005903 (brush border), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0016324 (apical plasma membrane), GO:0065010 (extracellular membrane-bounded organelle), GO:0031526 (brush border membrane), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)