Protein: Inositol oxygenase 4 (EC 1.13.99.1) (Myo-inositol oxygenase 4) (AtMIOX4) (MI oxygenase 4) (Q8H1S0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the oxygenative cleavage of myo-inositol to D-glucuronate. Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MTISVEKPIFEEVSAFEKSGDNIGELKLDGGFSMPKMDTNDDEAFLAPEMNAFGRQFRDYDVESERQKGVEEFYRLQHINQTVDFVKKMRAEYGKLDKMVMSIWECCELLNEVVDESDPDLDEPQIQHLLQSAEAIRKDYPNEDWLHLTALIHDLGKVITLPQFGGLPQWAVVGDTFPVGCAFDESNVHHKYFVENPDFHNETYNTKNGIYSEGCGLNNVMMSWGHDDYMYLVAKENGSTLPSAGQFIIRYHSFYPLHTAGEYTHLMNEEDKENLKWLHVFNKYDLYSKSKVHVDVEKVKPYYMSLIKKYFPENLRW
InterPro domains: - IPR007828: Inositol oxygenase (family) [22-317]
Interaction partners: - Probable glucuronokinase 2
- Glucuronokinase 1
- Inositol-phosphate phosphatase
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1
- Phosphatase IMPL1, chloroplastic
- Bifunctional phosphatase IMPL2, chloroplastic
- Probable CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2
- Inositol 3-kinase
- Aldo-keto reductase family 4 member C10
- GDP-L-galactose phosphorylase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016701 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0044282 (small molecule catabolic process), GO:0006629 (lipid metabolic process), GO:0010646 (regulation of cell communication), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006066 (alcohol metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010817 (regulation of hormone levels), GO:1901575 (organic substance catabolic process), GO:0010033 (response to organic substance), GO:0046883 (regulation of hormone secretion), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009743 (response to carbohydrate), GO:0016054 (organic acid catabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:1902644 (tertiary alcohol metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019751 (polyol metabolic process), GO:0042593 (glucose homeostasis), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0010154 (fruit development), GO:0019752 (carboxylic acid metabolic process), GO:0046174 (polyol catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0034285 (response to disaccharide), GO:0034310 (primary alcohol catabolic process), GO:0009062 (fatty acid catabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)