Protein: Collagen alpha-1(XI) chain (P12107)
Organism: Homo sapiens (Human)
Function: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Sequence: MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEANIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG
InterPro domains: - IPR008160: Collagen triple helix repeat (repeat) [442-1541]
- IPR050149: Collagen superfamily (family) [582-940]
- IPR001791: Laminin G domain (domain) [73-228]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [38-243]
- IPR000885: Fibrillar collagen, C-terminal (domain) [1576-1805]
- IPR048287: Thrombospondin-like, N-terminal domain (domain) [38-229]
Interaction partners: - Collagen alpha-2
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-1
- Collagen alpha-2
- Lumican
- Collagen alpha-3
- Thrombospondin-2
- Collagen alpha-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0005201 (extracellular matrix structural constituent), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0008201 (heparin binding), GO:0030020 (extracellular matrix structural constituent conferring tensile strength), GO:0019838 (growth factor binding), GO:0005539 (glycosaminoglycan binding), GO:0043394 (proteoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051093 (negative regulation of developmental process), GO:0032963 (collagen metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009887 (animal organ morphogenesis), GO:0048729 (tissue morphogenesis), GO:1901576 (organic substance biosynthetic process), GO:0009611 (response to wounding), GO:0009888 (tissue development), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0016477 (cell migration), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0042060 (wound healing), GO:0043062 (extracellular structure organization), GO:0048880 (sensory system development), GO:0010256 (endomembrane system organization), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:1903224 (regulation of endodermal cell differentiation), GO:0044319 (wound healing, spreading of cells), GO:0002009 (morphogenesis of an epithelium), GO:0043588 (skin development), GO:0045229 (external encapsulating structure organization), GO:0060429 (epithelium development), GO:0097435 (supramolecular fiber organization), GO:0061024 (membrane organization), GO:0035313 (wound healing, spreading of epidermal cells), GO:0002011 (morphogenesis of an epithelial sheet), GO:0048592 (eye morphogenesis), GO:0030198 (extracellular matrix organization), GO:0001654 (eye development), GO:0090505 (epiboly involved in wound healing), GO:0007009 (plasma membrane organization), GO:0030199 (collagen fibril organization), GO:0150063 (visual system development), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0005581 (collagen trimer), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0043233 (organelle lumen), GO:0098644 (complex of collagen trimers), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0005583 (fibrillar collagen trimer), GO:0043227 (membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0005788 (endoplasmic reticulum lumen), GO:0098643 (banded collagen fibril), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0062023 (collagen-containing extracellular matrix), GO:0070013 (intracellular organelle lumen)