Protein: Meiotic recombination protein rec14 (Q09150)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination.
Sequence: MRKEYLVSHIEENAHQADIYSLNVVAGNLWSASGDSKIKKWSIGDAEHSLVEEIDTPHKLGVHHLATSLDENVVVSCGFGQDVYVWNPETNEFRDLGNNAQHPSECWSSCISPDGQTIAFTSVDGRIAVWDNPSDCKISELDTKGKFGLCIDYSPNGRFIVSGHQTGQLFLISTETGRLFHVLSGHTSPVRSVAFSPGSTLLAAAGDSKMITIYDVLSGDQVGQLRGHAAWIFAVAFNPVGDLLLSADVEGKIKIWDIDTMECISTQSETDGAIWAVAWYKNGFIVAGADKSIRWYRAAATE
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [1-302]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [29-298]
- IPR051510: Superkiller complex protein 8 (family) [5-299]
- IPR001680: WD40 repeat (repeat) [3-297]
Interaction partners: - Superkiller protein 3
- Putative ATP-dependent RNA helicase C550.03c
- Cell division control protein 73
- Tetratricopeptide repeat protein 1
- Meiotic recombination protein rec12
- RNA polymerase II-associated protein 1 homolog
- Mei4-dependent protein 2
- Meiotic recombination protein rec6
- Meiotic recombination protein rec7
- RNA polymerase-associated protein C651.09c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0016043 (cellular component organization), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006325 (chromatin organization), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0010467 (gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0006338 (chromatin remodeling), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006353 (DNA-templated transcription termination), GO:0006360 (transcription by RNA polymerase I), GO:0006361 (transcription initiation at RNA polymerase I promoter)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0005829 (cytosol), GO:0140535 (intracellular protein-containing complex), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0030880 (RNA polymerase complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0008023 (transcription elongation factor complex), GO:0043233 (organelle lumen), GO:0055029 (nuclear DNA-directed RNA polymerase complex), GO:0016591 (RNA polymerase II, holoenzyme), GO:0043227 (membrane-bounded organelle), GO:0000428 (DNA-directed RNA polymerase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0016593 (Cdc73/Paf1 complex), GO:0070013 (intracellular organelle lumen), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome)