Protein: AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) (Q86KI1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
Subcellular location: Cell membrane. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane. {ECO:0000250}.
Sequence: MSMNVTNPNIAKTSMRGLTNFISDLRNSPSKENEEKRVTKEMAHIRKEFKENKNIDGYQRRKYVCKLVYMYMLGYELDFGHMEAVTLLSSTKFSEKQIGYIALGILLNEQHEMLPLIINSFKEDLLARSDYFQSLALAAICNIGGKEVAEFLSPLIQKLLIANTSSPMVKKRCALAILRMNRKHIGLVTPDSWVERLVSVLDEPDFGVLTSLMSLLIELASENPIGWEPAIPKVIHLLKKIIINKEFPKEYVYYHVTCPWLQVKLLKFLRYFPAPDDSQGGKVLGEILTAVFAQSESAKAGTVNHKNSLNAVLFEAINLIIHLDNDPVLLKQTSLLLGRFITVKETNIRYLGLEAMSHFASLSNETSIMIKKYQDTVLLSLKDSDISIRRRALDLLYGMCDKNTCKHIVAELLSYLQTADYAIREELVIKIANLAEKFASNYSWYVDVILQLITTAGDFVSDDIWFRVVKIVTNHEDIQAYAASTVFNALQSRNCHETLIKVGGYILGEFGHLIADNPQSSPLVQFNILHSKFNTCGAPTKALLLSTYAKFVNLFPELTQQTQEVFKQHQSYIDAEIQQRACEYLNLTSLNEDLMQTVLDVIPAFIDAKDNSNTTSNTANNSNMINSQDSKISSGGFNQSPQPSQQQQQQQPPQQQQAQLQQNVSSNGLDLLDPFGLGLGNQQQQQQQPVQQAQPVYQQQQQAESFSPVQSDTVSSFGQQQQQQQGGFSSPTIQASSSPISSGGSDPMQIKILASYKRLCLVSEGVLYEDSMLQVGLKSEYQSGQGRLMLYYGNSSAFPLTNFNVTLNSIAGLTLQPQSIAPVIQPKAQLQQPVTFSCTSEFTESPVITINFLTPGKPITITLRLPIVISKFFEPLRLSSGDFFARWKTISGKPLEIQEIFKSTKPIDIQSYNRVIQEGLNITVLKQVDPNPNNIVASCLFPFGSNGQPINSYIRIETNPQANMCRLTIRSQSATLTNTIKNLLISHLQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [15-594]
- IPR012295: TBP domain superfamily (homologous_superfamily) [873-987]
- IPR050840: Adaptor Complexes Large Subunit (family) [20-963]
- IPR013041: Clathrin adaptor, appendage, Ig-like subdomain superfamily (homologous_superfamily) [754-871]
- IPR008152: Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain (domain) [757-866]
- IPR003164: Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (domain) [872-984]
- IPR009028: Coatomer/calthrin adaptor appendage, C-terminal subdomain (homologous_superfamily) [872-987]
- IPR011989: Armadillo-like helical (homologous_superfamily) [9-618]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [34-590]
- IPR017104: Adaptor protein complex AP-2, alpha subunit (family) [4-989]
Interaction partners: - AP-2 complex subunit mu
- AP-2 complex subunit sigma
- AP-1 complex subunit beta
- Clathrin heavy chain
- AP-4 complex subunit beta
- Epidermal growth factor receptor substrate 15 homolog
- ANTH domain-containing protein
- AP-3 complex subunit beta
- Clathrin light chain
- AP-3 complex subunit mu
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0140352 (export from cell), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0032940 (secretion by cell), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0035592 (establishment of protein localization to extracellular region), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0015031 (protein transport), GO:0045176 (apical protein localization), GO:0071692 (protein localization to extracellular region)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005905 (clathrin-coated pit), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0048475 (coated membrane), GO:0030119 (AP-type membrane coat adaptor complex), GO:0098797 (plasma membrane protein complex), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030139 (endocytic vesicle), GO:0030132 (clathrin coat of coated pit), GO:0043231 (intracellular membrane-bounded organelle), GO:0030118 (clathrin coat), GO:0098588 (bounding membrane of organelle), GO:0030131 (clathrin adaptor complex), GO:0012506 (vesicle membrane), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0030122 (AP-2 adaptor complex), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0030666 (endocytic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0030125 (clathrin vesicle coat), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0045334 (clathrin-coated endocytic vesicle), GO:0030669 (clathrin-coated endocytic vesicle membrane), GO:0030128 (clathrin coat of endocytic vesicle), GO:0030665 (clathrin-coated vesicle membrane)