Protein: Exocyst complex component 8 (Exocyst complex 84 kDa subunit) (O54924)
Organism: Rattus norvegicus (Rat)
Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12954101}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12954101}. Cell projection, growth cone {ECO:0000269|PubMed:12954101}. Cell projection {ECO:0000269|PubMed:21658605}. Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (PubMed:12954101). Localizes at the leading edge of migrating cells (PubMed:21658605). {ECO:0000250, ECO:0000269|PubMed:12954101, ECO:0000269|PubMed:21658605}.
Sequence: MSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRVQALAEETAQNLKRNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLALLPAAAAGASTGEDTAGAGPRERGAAQAGFLPGPAGVPREGPGTGEEGKQRTLTTLLEKVEGCRDLLETPGQYLVYNGDLVEYEADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYPLDRLAVVNVKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEVLEETKRALSDKRRREQEEAAALRAPPPVTSKGSNPFEDEAEEELATPEAEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPSVKELRAKVDERVRQLTEVLVFELSPDRSLRGGPKATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFETDFAGTDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGEIGLDLTFIIHALLVKDIQGALLSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMRSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEVILVAVQHVDYSLRCEQDPEKKTFIRQNASFLYDTVLPVVERRFEEGVGKPAKQLQDLRNASRLLRVNPESTTSVV
InterPro domains: - IPR001849: Pleckstrin homology domain (domain) [173-275]
- IPR042561: Exocyst component Exo84, C-terminal, subdomain 1 (homologous_superfamily) [316-437]
- IPR033961: Exocyst complex component Exo84 (family) [8-697]
- IPR042560: Exocyst component Exo84, C-terminal, subdomain 2 (homologous_superfamily) [442-544]
- IPR032403: Exocyst component Exo84, C-terminal (domain) [326-531]
- IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [321-545]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [167-279]
Interaction partners: - Exocyst complex component 3
- Exocyst complex component 6
- Exocyst complex component 2
- Exocyst complex component 7
- Exocyst complex component 5
- Exocyst complex component 4
- Exocyst complex component 1
- Ras-related protein Ral-B
- Ras-related protein Ral-A
- Exocyst complex component
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0140352 (export from cell), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0006810 (transport), GO:0010506 (regulation of autophagy), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis), GO:0045229 (external encapsulating structure organization), GO:0043062 (extracellular structure organization), GO:0006996 (organelle organization), GO:0031329 (regulation of cellular catabolic process), GO:0010256 (endomembrane system organization), GO:0022411 (cellular component disassembly), GO:0016050 (vesicle organization), GO:0022617 (extracellular matrix disassembly), GO:0030198 (extracellular matrix organization), GO:0007032 (endosome organization), GO:0016241 (regulation of macroautophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)