Protein: 2-oxoacid:ferredoxin oxidoreductase 1, subunit beta (OFOR1) (EC 1.2.7.11) (Q96Y68)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Function: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
Sequence: MAAFKPQWNDWCPGCGNFGILNAEQQAIVELGVDTKNVVVVSGIGCSGKIPHFFRTPISGVHTLHGRAIAFATGIKLSNPDLVVIVNGGDGDLLGIGAGHFVAAGRRNVDMVVILHDNGVYGLTKGQASPTLKRGEKPKSLPRPNINDAVNPIALAISSGYTFVARGYAYDVKHLKELIKSAIKHKGLALIDVLQPCPTYNDINTKEWYDKRIYKLDTLPDWDPVVKKPEEVNEKIKRAIDKSLEWGDRIPIGIFYQNELVPSYEERIKANSPAYLDYTPAKQLIEKEGKLTTIIDPLLKEREVD
InterPro domains: - IPR051457: 2-oxoacid:ferredoxin oxidoreductase (family) [5-272]
- IPR011896: 2-oxoacid:acceptor oxidoreductase, beta subunit (family) [10-287]
- IPR029061: Thiamin diphosphate-binding fold (homologous_superfamily) [9-269]
- IPR032686: Pyruvate ferredoxin oxidoreductase beta subunit, C-terminal (domain) [197-270]
- IPR053399: 2-oxoacid:ferredoxin oxidoreductase beta subunit (family) [7-304]
- IPR011766: Thiamine pyrophosphate enzyme, TPP-binding (domain) [45-193]
Interaction partners: - 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha
- 2-oxoacid:ferredoxin oxidoreductase 1, subunit alpha
- 2-oxoacid oxidoreductase
- pyruvate synthase
- pyruvate synthase
- 2-oxoacid oxidoreductase
- Succinyl-CoA synthetase beta subunit
- Pyruvate kinase
- Succinate--CoA ligase subunit alpha
- Indolepyruvate--ferredoxin oxidoreductase beta subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0035383 (thioester metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006637 (acyl-CoA metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0034032 (purine nucleoside bisphosphate metabolic process), GO:0033865 (nucleoside bisphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0033875 (ribonucleoside bisphosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)