Protein: Sodium-dependent phosphate transport protein 2A (Sodium-phosphate transport protein 2A) (Na(+)-dependent phosphate cotransporter 2A) (NaPi-6) (Sodium/phosphate cotransporter 2A) (Na(+)/Pi cotransporter 2A) (NaPi-2a) (Solute carrier family 34 member 1) (Q28620)
Organism: Oryctolagus cuniculus (Rabbit)
Function: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity).
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q06495}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q06496}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation. {ECO:0000250|UniProtKB:Q06496, ECO:0000250|UniProtKB:Q60825}.
Sequence: MISYGEQLSSPAVSPPLVRAGLRGPMMHGATFAYVPSPQALHRIPGTSAYAFPSLSPVALTEHGCPYGEARERHEPLPAKLALEEEQKPESGWAQELRRTAMTLLKLPLMVTFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILANPVAGLVVGILVTVLVQSSSTATSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKTITEPFTKLIIQLDRSVITSIATGDESLRNHSLIRIWCHRDPVEASTSMARAETNISRTHGNATMEKCNHIFVDTQLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDLPAPFTWVTGYFAMVVGAAMTFIVQSSSVFTSAITPLVGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWRAMVGVGAPFGALLAFVVLINVLQSRSPGRLPKWLQTWDFLPHWMHSLQPLDHLITHATLCCSRSEPRSPQLPARVFLEELPPATPSPRLALPAHHNATRL
InterPro domains: - IPR003841: Sodium-dependent phosphate transport protein (family) [77-605]
Interaction partners: - Sodium-dependent phosphate transport protein 2B
- Fibroblast growth factor 23
- Sodium/glucose cotransporter 2
- Klotho
- Sodium-dependent phosphate transport protein 1
- Parathyroid hormone
- Phosphate transporter
- Phosphate transporter
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0005436 (sodium:phosphate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0015698 (inorganic anion transport), GO:0006817 (phosphate ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium)