Protein: Cadherin-5 (Vascular endothelial cadherin) (VE-cadherin) (Q8AYD0)
Organism: Gallus gallus (Chicken)
Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.
Subcellular location: Cell junction, adherens junction {ECO:0000250|UniProtKB:Q68SP4}. Cell membrane {ECO:0000250|UniProtKB:P33151}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P33151}. Cytoplasm {ECO:0000250|UniProtKB:P55284}.
Sequence: MKKLILLFSLFLAPAFSYKENQKINQNFSSNNTSHKRLKRDWIWNRMHIREEIDSPLPHHVGKLTSSVGNKNAMYIIEGESANTIFKVQGYDGDIYAFERLDREKKAEYELTAHIIDRRNNRSLEPPSKFIIKVSDINDNAPIFVQKIFNGSVPEMSRLGTSVTKVTAEDADDPTVAGHATVTYQIIKGNEYFTVDDSGVISTARADLDRESQSAYEIIVKAKDALGLTGESSTATVIIRLTDINDNFPVFKHPSFHFRVPENISVGGEVGRVKVEDIDEPQHRNTKYSFVRGDYRDTFEIIANPFTNEGIIRPKKPLDFEKVAEYRFDIEATDHNVNPAYYKPGGSRSISTITIEVTDVDEPPVFTKLSYEFKVRENDPEIKTLGSVWAHDPDAAKRKIRFARRRASPNGDYVRVSDSGIIQLPKPLDREFSSLYNITVAAQEILEDGRLSDRESHAQVHVIVTDENDNAPELVYPEEPRVCENAAPGKVIIRISATDKDEISPGGFFTYSLTTEDSNFSLTENPDNTANITVKDGQFNRELAKIHYLPVIISDNGNPELSSTNTLVISVCKCNEKGDFTFCEERAKQVGVSVQALVAIFICIFTIIAVIALLILLRKRHKKDLSGLRRNVAEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRKNGIKPEVVPSAYAQVQKPPGNTTSGAGEMEMMIEVKKDEADNDRDLLPYDTLHIYGYEGAESIAESLSSLESGSSDSDIDYDFLNDWGPRFKMLAELYGSEPNEDFVY
InterPro domains: - IPR027397: Catenin binding domain superfamily (homologous_superfamily) [671-768]
- IPR000233: Cadherin, Y-type LIR-motif (domain) [705-764]
- IPR002126: Cadherin-like (domain) [47-582]
- IPR039808: Cadherin (family) [24-766]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [70-572]
- IPR020894: Cadherin conserved site (conserved_site) [239-472]
Interaction partners: - Vascular endothelial growth factor receptor 2
- Platelet and endothelial cell adhesion molecule 1.
- Plakoglobin
- Claudin
- Catenin beta 1
- Catenin delta 1
- Uncharacterized protein.
- Cadherin-1
- Uncharacterized protein
- Catenin alpha 1.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048523 (negative regulation of cellular process), GO:0035295 (tube development), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0009888 (tissue development), GO:0007162 (negative regulation of cell adhesion), GO:0048731 (system development), GO:0030155 (regulation of cell adhesion), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0007399 (nervous system development), GO:0021915 (neural tube development), GO:0022407 (regulation of cell-cell adhesion), GO:0002009 (morphogenesis of an epithelium), GO:0022408 (negative regulation of cell-cell adhesion), GO:0060429 (epithelium development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0009792 (embryo development ending in birth or egg hatching), GO:0072175 (epithelial tube formation), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0001841 (neural tube formation), GO:0060232 (delamination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)