Protein: Suppressor of cytokine signaling 3 (Q6NYJ2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Sequence: MVTHSRLDSAMSSSPFEGGVRLPPHRYKTFSSREQYQMVLAAVRKLQESGFYWSTVSGKEASTLLSSEPPGTFLVRDSSDHHHFFTLSVKTATGTKNLRIQCDSSSFFLQTDPRSEQVVPRFDCVLKLIHHYMPSAGTVSSSNAGEGSAYFIYSGGEKIPLELLRPLASSMSSLQHLCRKTLNGHIDVSTKRDQLPHPLQEFLQEYDAPI
InterPro domains: - IPR036860: SH2 domain superfamily (homologous_superfamily) [23-170]
- IPR001496: SOCS box domain (domain) [162-209]
- IPR036036: SOCS box-like domain superfamily (homologous_superfamily) [161-209]
- IPR035863: SOCS3, SH2 domain (domain) [40-140]
- IPR000980: SH2 domain (domain) [49-167]
Interaction partners: - Tyrosine-protein kinase JAK1
- Tyrosine-protein kinase
- Tyrosine-protein kinase
- Leptin receptor
- Suppressor of cytokine signaling 3
- Insulin receptor substrate 1
- Tyrosine-protein kinase receptor
- Insulin receptor substrate 2
- Insulin receptor substrate 2-B
- Signal transducer and activator of transcription
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0008283 (cell population proliferation), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0070570 (regulation of neuron projection regeneration), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0080135 (regulation of cellular response to stress), GO:0032101 (regulation of response to external stimulus), GO:0060041 (retina development in camera-type eye), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0051128 (regulation of cellular component organization), GO:0031099 (regeneration), GO:1903035 (negative regulation of response to wounding), GO:0070571 (negative regulation of neuron projection regeneration), GO:0032102 (negative regulation of response to external stimulus), GO:0048681 (negative regulation of axon regeneration), GO:0048882 (lateral line development), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0061008 (hepaticobiliary system development), GO:0048666 (neuron development), GO:0030855 (epithelial cell differentiation), GO:0048679 (regulation of axon regeneration), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0008544 (epidermis development), GO:0031345 (negative regulation of cell projection organization), GO:0060429 (epithelium development), GO:0030182 (neuron differentiation), GO:0042490 (mechanoreceptor differentiation), GO:0048925 (lateral line system development), GO:0035675 (neuromast hair cell development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0070365 (hepatocyte differentiation), GO:0048884 (neuromast development), GO:0150063 (visual system development), GO:0035315 (hair cell differentiation), GO:0001889 (liver development), GO:0010977 (negative regulation of neuron projection development), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation), GO:0048916 (posterior lateral line development), GO:0048881 (mechanosensory lateral line system development), GO:0048886 (neuromast hair cell differentiation), GO:0048915 (posterior lateral line system development), GO:0043010 (camera-type eye development), GO:0048919 (posterior lateral line neuromast development), GO:0048593 (camera-type eye morphogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)