Protein: Cadherin EGF LAG seven-pass G-type receptor 1 isoform X2 (Cadherin EGF LAG seven-pass G-type receptor 1a) (F1R9W4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MDLVMCWLLWVHLLLCAPLMGCFDLHLSETLHSGAVLANLSLGPGWTYKIDWTLTSKYIGNFIKVDWRDGVVRLNGEVDCARAPHSALPLYFKIKSLTTEGLVKTHFNVFLHGQNCVFKFKRKRETKPDINVNYIYNSGLTSCLSPGDLLIHFEDYLPVFTRNSAVFASSCTSDQLNVFVRNGTLLVKDAYCLETNLGRFKSTIRCSFLDSKGEPFSVCLKLRFTSDQTSLSYVTNPRKQRIKRAANSVPQFQLSNYQVSVPENEPAGTRVITLKATVSDPGETGKIEYGMEALFDSRSNDFFRIDPQTGSIETAQPLDREVKDTHVFKVTASVAGFAKRAATSYLTITVSDTNDHGPVFEQNEYRVRIRENVEVGFEVITVRATDGDAPSNANMIYRIMNEEGVNSGFEIDSWNGLVKIKVRPDRETMAQYQLIVEASDQGKEPGPRSATATVHITVEDENDNYPQFSEKRYVVQVPENVAVNTKVAQVEATDRDEGNNARVHYSIISGNVKGQFFIHTPTGAIDVINPLDYETIREYNLRIKAQDGGRPPLINGTGVVVVQVVDVNDNAPMFVSTPFQATVLENVPIGYSVIHIQAIDSDSGENARLDYSLTDTTPGFPFSINNSTGWITVSDELDRESTEFYTFGVEARDNGVPVMSSSASVSITVLDVNDNIPTFTEKMYSLKINEDAVVGTSVLTVTALDRDVNSVVTYQISSGNTRNRFAITSQSGGGLITLALPLDYKQERQYVLTITASDGTRFDTAQVFINVTDANTHRPVFQNANYHQTFSEDQPIGSTVVVISATDEDTGENARITYIMEDNVPQFKIDPDSGAITTQMEIDYEDQASYTLAIIARDNGIPQKSDTTYVEIIILDANDNSPRFGRDKYQGTVFEDAPIYTSVLQISASDRDSGSNGRVSYTFQGGDDGEGDFMIEQYSGIIRTHRKLDRENVPVYNLRAYAVDRGVPPLKAAVEIQVSVLDINDNAPVFEKDELYIDVKENSPVDSVVARITAMDPDEGTNAQILYQIVEGNIPEVFDLDIFTGDLKALVDLDYETQKEYVIVVQATSAPLVSRATVHVRLIDVNDNDPVLQNFEIIFNNYVTNKSNSFPSGIIGKVPAHDPDVSDKLKYSFIEGNELSLLILNPDTGELKLSKDLDNNRPLEATMKVSVTDGIHQVTAFCTLRVTIITDEMLTNSITVRLENMSQERFLSPLLSLFVKGVAAVLSTSREGVFIFNVQNDTDVSGNILNVTFSALLPGGVPDRYFPSEELQEQIYLNRTLLQEISSQNVLPFDDNICLREPCENYMKCVSVLKFDSSPPFIASDTVLFRPIHPINGLRCRCPAGFTGDYCETEIDLCYSGPCRNNGRCRSREGGYTCECLEDFTGENCEVDSRSGRCVPGVCKNGGECVNLLVGGFTCNCPSGEYEKPFCEMTTRSFPGQSFITFRGLRQRFHFTVSFMFATRERNALLLYNGRFNEKHDFIAVEIIEEQIQLTFSAGESKTTVAPFVPGGVSDGQWHSVQLHYYNKDSLHLLDSSGVLSVHLYTAWLELTHKEPKISHLGLPQGPSGEKVAVVAVDDCDIAMAVRFGTQIGNYSCAAQGTQTGQKKSLDLTGPLLLGGVPNLPEDFPIRNRDFVGCMRNLTIDSKSVDMASYIANNGTTEGCPAKKNFCYEGLCQHGAQCENKWNTHFCECPEGRGGKNCDQDMPSRQHFDGHAMMLWNDPDMTIAVPWYIALMFRTRQTSQTATLMQVNAGDTSQINLLIRDKYVQFEVLLGEQKVAVLDFTDVRVNDGEWHHLLVELRSSKDGKDTKYMAQVLLDYDMFKKSVEIGNELPGLKLKSFFIGGLQGQRDIVQQGFKGCMQGLRMGETATSTANINMHHAQKIRVEDGCDMSENCDAINCPENSQCTDEHTCTCDPGFFGRDCVDACHLNPCEHLSTCVRKPSSSHGYTCECSQDYYGQYCENKVEKPCPRGWWGNPMCGPCNCDVSKGFNPDCNKTTGECRCKDNYYQPKDSDTCFPCDCFHLGANSRTCDPETGQCPCKAGVIGRQCNRCDNPFSEVTSTGCEVGYEGCPKAFDSGIWWPRTNFGFPVAMNCPKGSIGTAVRHCNDEKGWLPPELFNCTTITFSHLKKMNDDLHRNESSMDGQKSRDIARMLHNATDQTSSFYGNDIKTTYHLLSSILRYESQQQGFNLAAMRDAKFNENLVKAGSAILDASNKEHWDQIQRTEGGTANLLKHFEEYANTLAQNMRKTYLKPFIIVTENMVFAVDYLVTYPDATKVPNFQTTDQECPKDLKSSVLFPEFSFKSSEHKVSPTDDPEFQINSDEEEKQATNKRKRHVETIPPFPVASVIIYKTLGQFLPEHYDPDRRSLRVPNRPVINTPIVSATVYSEGQPLHIPLERPITLDYNLLETEERTKPVCVFWNHSITVGGAGAWSSKGCDIISRNHTHISCQCNHMTSFAVLMDISKREHGDVLPLKIVTYTTVSASLLALFITFILLAILHKLRSNLHSIHKNLVAALFFSELVFLIGINQTDNPFVCTVIAILLHYFYMCTFAWTFVEGLHIYRMLTEVRNINHGHMRFYYAIGWGIPAIITGLAVGLDPQGYGNPDFCWLSVHDTLIWSFAGPIAVVVLVNIVIFVMAAKASCGRRQRSYEKSGVTPALRMAFLLLLLISATWLLGLMAVNSDVMTFHYLFAIFSCLQGVFIFFFHIVFNKEVRKNLKNVFTGKKQLPDESSTTRTTLLTRTLNCNNTYMEDGALFRSAIGESTVSLESTVRSAKSHSSYFTYTHRDELGQKPSVSGNAKAGLTDIDGSLFRNGTKADDSDSDSELSVDEHSSSYASSHSSDSEDEDIDMQPKWNNERQPLHSTPKGTKEVDTVSNHVKPYWPTEAMTASDSEDPGGAERLRVETKVNVELHQENKLNHIGESTQDKEQPTPSIQANSNHQPEQRKGILKNKITYPPPLTDKNMKNKLREKLSDYNPPTISSRAPSITSNDGGNGHNVLIKPPRPPVPPREHLNGMAMNLKSATVNGGNQSDSDGSNETSI
InterPro domains: - IPR001879: GPCR, family 2, extracellular hormone receptor domain (domain) [2052-2130]
- IPR032471: AGRL2-4 , GAIN subdomain A (domain) [2148-2389]
- IPR002126: Cadherin-like (domain) [253-1215]
- IPR001881: EGF-like calcium-binding domain (domain) [1354-1703]
- IPR000832: GPCR, family 2, secretin-like (family) [2475-2705]
- IPR001791: Laminin G domain (domain) [1433-1890]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [1414-1890]
- IPR046338: GAIN domain superfamily (homologous_superfamily) [2226-2456]
- IPR000203: GPS motif (conserved_site) [2415-2468]
- IPR056286: CELSR1-3-like, ninth cadherin domain (domain) [1084-1177]
- IPR000742: EGF-like domain (domain) [1294-1963]
- IPR002049: Laminin-type EGF domain (domain) [2019-2072]
- IPR036445: GPCR family 2, extracellular hormone receptor domain superfamily (homologous_superfamily) [2054-2119]
- IPR017981: GPCR, family 2-like, 7TM (domain) [2476-2713]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [249-1189]
- IPR057244: GAIN, subdomain B (domain) [2294-2469]
- IPR020894: Cadherin conserved site (conserved_site) [562-1090]
Interaction partners: - Vang-like protein
- Vang-like protein 2
- Prickle homolog 1a
- Frizzled-3
- Frizzled class receptor 6
- Prickle homolog 2b
- Prickle homolog 1b
- Cadherin, EGF LAG seven-pass G-type receptor 2.
- Prickle homolog 2a.
- Dishevelled segment polarity protein 1b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0035295 (tube development), GO:0009790 (embryo development), GO:0048598 (embryonic morphogenesis), GO:0016477 (cell migration), GO:0048513 (animal organ development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0007369 (gastrulation), GO:0007399 (nervous system development), GO:0060429 (epithelium development), GO:0021915 (neural tube development), GO:0072359 (circulatory system development), GO:0001667 (ameboidal-type cell migration), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0042074 (cell migration involved in gastrulation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)