Protein: PITH domain-containing protein 1 (Q9GZP4)
Organism: Homo sapiens (Human)
Function: Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:25134913}.
Sequence: MSHGHSHGGGGCRCAAEREEPPEQRGLAYGLYLRIDLERLQCLNESREGSGRGVFKPWEERTDRSKFVESDADEELLFNIPFTGNVKLKGIIIMGEDDDSHPSEMRLYKNIPQMSFDDTEREPDQTFSLNRDLTGELEYATKISRFSNVYHLSIHISKNFGADTTKVFYIGLRGEWTELRRHEVTICNYEASANPADHRVHQVTPQTHFIS
InterPro domains: - IPR010400: PITH domain (domain) [20-192]
- IPR037047: PITH domain superfamily (homologous_superfamily) [24-186]
- IPR045099: PITH domain-containing protein 1-like (family) [7-208]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [22-176]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0050793 (regulation of developmental process), GO:0048869 (cellular developmental process), GO:0044706 (multi-multicellular organism process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0009566 (fertilization), GO:0032504 (multicellular organism reproduction), GO:0051094 (positive regulation of developmental process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:2000026 (regulation of multicellular organismal development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:1903706 (regulation of hemopoiesis), GO:0080090 (regulation of primary metabolic process), GO:0007338 (single fertilization), GO:0007283 (spermatogenesis), GO:0045637 (regulation of myeloid cell differentiation), GO:0045639 (positive regulation of myeloid cell differentiation), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0060284 (regulation of cell development), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0045652 (regulation of megakaryocyte differentiation), GO:0030162 (regulation of proteolysis), GO:0061136 (regulation of proteasomal protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)