wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Protein misato (O01939)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000250}.
Sequence: MDYTREILTFQFGTYANYVGTHFWNQQEANFRYGDESEQVAEEQLPNNDILYREGRNDLNRTTYTPRLLSVDLSGTLGHLPVTGELYGNFVQRDEELLPLSTGEELEQVRKRAEESGVCSPEQLEVQEQSKASISEYQRDLLKNAVVPEKNYQLAATANSWVDFLYARYHPRTLNVLPGLIRDPTAQALGTYSAGTEMWQEVSFNEEFCDRIRLYVEECDGLQGFHVLFDIDDGFGGLAGKCLEHLNDEYSRASFALPLHYPRITSYPQADTRLSHSIRVVNNVLGYHQLSEQALMFTPLSTLETIWRNNNLKSRSLPGLQWETDNLYQTSALLAAFFDTATLSYRLRQTPESLLRFCECVTPAGRKMTAAGLALPFGLREGQDLIEFLDQSGDHALLTQLTPGCEPGTSYVVQSVTARGIPAERLKRPRELAGDQLRMAAYSCDSISHMLQLYYQCTYHGSVTNAAATPLPLKTQLPFPYEMFAAGISRDGYRLPEGAERETGSRVDSAPMLAAVQNSTKLGEHLDNVHAQSHRVQLAKLQAYSNSGLERDEYDTALDQLLEFRDLYADSQYL
InterPro domains: - IPR049942: DML1/Misato (family) [5-572]
- IPR029209: DML1/Misato, tubulin domain (domain) [157-347]
- IPR019605: Misato Segment II tubulin-like domain (domain) [5-142]
- IPR036525: Tubulin/FtsZ, GTPase domain superfamily (homologous_superfamily) [3-370]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0043015 (gamma-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0007017 (microtubule-based process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0007018 (microtubule-based movement), GO:0051649 (establishment of localization in cell), GO:0031323 (regulation of cellular metabolic process), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0051656 (establishment of organelle localization), GO:0051647 (nucleus localization), GO:0007097 (nuclear migration), GO:0010970 (transport along microtubule), GO:0099111 (microtubule-based transport), GO:0072384 (organelle transport along microtubule), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0008088 (axo-dendritic transport), GO:0098930 (axonal transport), GO:0008090 (retrograde axonal transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Inka box actin regulator 2 (E9PR53)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGGGPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLEQPEPTSGAFPIRCS
InterPro domains: - IPR039201: PAK4-inhibitor inka (family) [3-102]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0007423 (sensory organ development), GO:0042461 (photoreceptor cell development), GO:0046530 (photoreceptor cell differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0048699 (generation of neurons), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7) (Q8N3Z6)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:21855801}.
Sequence: MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSEVITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLGCEVDDKDDDILLNLVGCENSVTEGEDGINWSISDKDIEAQIANNRTPGRWTQRYYSANKNIICRNCDKRGHLSKNCPLPRKVRRCFLCSRRGHLLYSCPAPLCEYCPVPKMLDHSCLFRHSWDKQCDRCHMLGHYTDACTEIWRQYHLTTKPGPPKKPKTPSRPSALAYCYHCAQKGHYGHECPEREVYDPSPVSPFICYYDDKYEIQEREKRLKQKIKVLKKNGVIPEPSKLPYIKAANENPHHDIRKGRASWKSNRWPQENKETQKEMKNKNRNWEKHRKADRHREVDEDFPRGPKTYSSPGSFKTQKPSKPFHRSSHYHTSREDKSPKEGKRGKQKKKERCWEDDDNDNLFLIKQRKKKS
InterPro domains: - IPR051644: TRAMP complex component and AT-rich DNA-binding protein (family) [2-519]
- IPR001878: Zinc finger, CCHC-type (domain) [242-365]
- IPR036875: Zinc finger, CCHC-type superfamily (homologous_superfamily) [233-281]
Interaction partners: - Exosome RNA helicase MTR4
- Terminal nucleotidyltransferase 4B
- Terminal nucleotidyltransferase 4A
- Poly
- Poly
- Poly
- Zinc finger CCHC domain-containing protein 8
- Exosome complex component 10
- RNA-binding protein 7
- Exosome complex exonuclease RRP44
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0003723 (RNA binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Actin maturation protease (EC 3.4.11.-) (Actin aminopeptidase ACTMAP) (Q5BKX5)
Organism: Homo sapiens (Human)
Function: Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation. Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation. Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:36173861}.
Sequence: MTSPCSPPLKPPISPPKTPVPQASSIPSPPLPPSPLDFSALPSPPWSQQTPVPPPLPLPPPPAATGPAPRHVFGLEKSQLLKEAFDKAGPVPKGREDVKRLLKLHKDRFRGDLRWILFCADLPSLIQEGPQCGLVALWMAGTLLSPPSGVPLERLIRVATERGYTAQGEMFSVADMGRLAQEVLGCQAKLLSGGLGGPNRDLVLQHLVTGHPLLIPYDEDFNHEPCQRKGHKAHWAVSAGVLLGVRAVPSLGYTEDPELPGLFHPVLGTPCQPPSLPEEGSPGAVYLLSKQGKSWHYQLWDYDQVRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH
InterPro domains: - IPR040043: Actin maturation protease (family) [52-350]
Interaction partners: - U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm5
- Small nuclear ribonucleoprotein Sm D2
- U6 snRNA-associated Sm-like protein LSm6
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm4
- Small nuclear ribonucleoprotein-associated protein N
- U6 snRNA-associated Sm-like protein LSm8
- Spliceosome associated factor 3, U4/U6 recycling protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008238 (exopeptidase activity), GO:0004177 (aminopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis), GO:0010467 (gene expression), GO:0016485 (protein processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen)
Protein: Auxin response factor (A0A2H1ZEC0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004561}.
Sequence: METGNVVNAQPELSGIIDGSKSYMYEQLWKLCAGPLCDIPKLGENVYYFPQGNIELVDASTREELNELQPICDLPSKLQCRVIAIHLKVENNSDETYAEITLMPDTTQVVIPTQSENQFRPLVNSFTKVLTASDTSAYGGFFVPKKHAIECLPPLDMSQPLPAQELLAKDLHGNQWRFRHSYRGTPQRHSLTTGWNEFTTSKKLVKGDVIVFVRGETGELRVGIRRARHQQGNIPSSIVSIDCMRHGVIASAKHALDNQCIFIVVYKPRSSQFIVSYDKFLDAMNNKFIVGSRFTMRFEGDDFSERRYFGTIIGVNDFSPHWKCSEWRSLEVQWDEFASFSRPNKVSPWEIEHLMSALNVPRSSLLKNKRLREVNEFGQEIGQLSVASPMNTSLRYRDTTEDAMNPSRLLMSYPVQPMPKLNYNNQMVTQIEENITTKAVTNFRLFGVSLAIPLVIKDPIEEIGSDISKLTEGKKFGQSQTLRSPIEIQSKQFGSTRTCTKVQMQGVTIGRAVDLSVLNGYDQLILELEKLFDLKGQLQTRNQWKIAFTDSDGYEMLVGDDPWPEFCKMVKKILIYSKEEVKNLKSSKSLSS
InterPro domains: - IPR033389: AUX/IAA domain (domain) [494-533]
- IPR015300: DNA-binding pseudobarrel domain superfamily (homologous_superfamily) [123-247]
- IPR003340: B3 DNA binding domain (domain) [125-228]
- IPR053793: PB1-like domain (domain) [497-578]
- IPR044835: Auxin response factor (family) [23-585]
- IPR010525: Auxin response factor domain (domain) [273-354]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Testis-specific gamma-tubulin ring protein 128 (Q8IRA1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MQEDERQKVIERNLPHLVSVLLGSPIDDKKNDNGQVSVEPATFDKCLTYARCHIADPNVVDCDPDAVWDTMNQFLERFRIENLSVFGDTFNQLANVILNHPICMNHKQRNIHWRLLDFVLSVNYKTFVSIRRNLPEMEQKRKNILEALQMATESSQVDPKDKNNTKCVADTEDQLIHKKSQKPKSPRKKLTPDQIQRLCDEIRDLTSSKYGSLHTVRSQIPMEQSKPLDTSDYNYSRELNLGKVAVKENFTIKGAKMELELNVVQNKPSAEKPALVDFFKNESDMLYRIQTNWWQVDISVYNQAHILASNFCQGYADILIFQLWESQASIRKLSEEHQLLSELIVLFFASANCRSFKILNDNWEFRADEPLTCALKQLQEGPHLGEIIKSLKQMRHLRELIETYAVKGIRYDRLKTLTFFSVALRQLLRPVIEFLVHFERRLTSGLEPATLQHFIETSRGHLETIKLLYELSQNKNQELHSLRSLKTLDTLFTKSSQKTQPKLLRSLSASLLLHTVRAYCKFLDNWWSTGDFADYHEEFPFEKIVTDERTEYVLRKSLMQTELQNSELFRIIQRHLLESSDGVAILYDSRTISEFHTLHGIEPEIRLHNSLIDAVIGEIAPYQIKAIEASHYVPDILQQLQSTDHDGIRRLFYSFHMETRPDPRKPAGHSINELLRNFLTCADYTPITEIISQEFQRLLNRRTRLVNSYISGLLQEFQGYKVVRHLRSVFLLWNYDHFRSEFEFFFEFLRRKHLVEATNKLKHIVLCQDFTLGHMFKVCVTEAHPEFICLRVRNDTLLNRIISQQQMDMMNSCFRLLLNLNFSHYRLNHLPPFHYCKYERLFKALRSIQISLISVFEEHLSHPCKLFRKMQNLDSYNSELNEFTSLTQLRRNQEIFGLHIRKYLLEEQFACSLPEILTLSKVFCLRWETTRALVDEYRSQKATSTFERRYKLLRLNYLLETVKKCKAIGCLLGHI
InterPro domains: - IPR041470: Gamma tubulin complex component protein, N-terminal (domain) [385-539]
Interaction partners: - Testis-specific gamma-tubulin ring protein 91
- Gamma-tubulin complex component
- Grip163
- Gamma-tubulin complex component 2 homolog
- Gamma-tubulin complex component 3
- Grip71
- Gamma-tubulin complex component 4 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0043015 (gamma-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000930 (gamma-tubulin complex), GO:0005813 (centrosome), GO:0043229 (intracellular organelle), GO:0000931 (gamma-tubulin ring complex), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Endonuclease/exonuclease/phosphatase, putative (Q384N6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MYTTMPNSPLAIPHHFLDIGKDESSPPMTRNDTNSSGLASFQPTDDQVAEGFPSLGVSTASPTHRTTLQERREKLLGGSFLSLCVETLQNDCPEAIEGDCNSNRTVFRGWSKTDLGVSSQALSNNGVVRLVCYNILAQRFLSMQRYPRCPPFALAEDYRCGFAEQELLQADPDIILLQEISVDVFGKPGLLGENLREKHGFIGNHVVVTDLSGRPRHTSFDSSTDGAQAVVFQEVTTSSSKPSPSGTVESRRSNDVAAEKTVEPPRSDLEGVATFFLKDRFELLEVIPIRLNEIANADKTLTQSERRSLRRMSHNVALITVLRDLNKPNVIYVVCNLHLLWSGSRCQLWQLHRVMSYIEQVKGEHESHIENSNGECPIVAVVLGGDFNSESWEPPIAYALNGSLPESSNVGAWCGTPGRETGAFSPISRDTDVDVENSKSGTPMVESPCGAGGGGTCSGFTAPAAGHSLALTDVYEIYRERHPRRVSFVDPGDGGKGKVYDHILIDKRHLGCTDVLRLSSSTNLPAPNCPSDHCPVGAVIVPLCLLS
InterPro domains: - IPR050410: CCR4/nocturin mRNA turnover and transcription (family) [94-539]
- IPR036691: Endonuclease/exonuclease/phosphatase superfamily (homologous_superfamily) [99-542]
- IPR005135: Endonuclease/exonuclease/phosphatase (domain) [165-533]
Interaction partners: - NOT1
- poly
- Cell differentiation protein, putative
- NOT2/NOT3/NOT5 C-terminal domain-containing protein
- Uncharacterized protein
- Probable eukaryotic initiation factor 4A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004527 (exonuclease activity), GO:0008408 (3'-5' exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0034470 (ncRNA processing), GO:0031123 (RNA 3'-end processing), GO:0034660 (ncRNA metabolic process), GO:0042780 (tRNA 3'-end processing), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Uncharacterized protein AT4g03420 (Uncharacterized protein F9H3.4) (Q9ZT70)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MVFGKGSNLDRFLHCTTPVVPPQSLSKAEIRSLNRIWHPWERQKVEFFRLSDLWDCYDEWSAYGAGVPIRLSNGESLVQYYVPYLSAIQIFTSRSSLIRLRDDSEDGESRDSFSDSYSDESESDKLSRCASDEGLEHDALLHPNDRLGYLYLQYFERSAPYARVPLMDKINELAQRYPGLMSLRSVDLSPASWMAVAWYPIYHIPMGRTIKDLSTCFLTYHTLSSSFQDMEPEENGGEKERIRKEGEGVTLLPFGLATYKMQGNVWLSEDDQGQDQERVLSLLSVADSWLKQLRVQHHDFNYFSRMAHLARRLLFSLVAIYRVCPVVGVAVAAVKRTERFLNTQVQRFQRFGCRIALK
InterPro domains: - IPR008507: Protein of unknown function DUF789 (family) [7-303]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0071456 (cellular response to hypoxia), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Malate dehydrogenase (EC 1.1.1.37) (Q383F3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSNTCKRVAVTGAAGQIGYSLLPLIAAGRMLGFDQRVQLQLLDISPALKALEGIRAELMDCSFPLLDGVVITDEPKVAFDKADIAILCGAFPRKPGMERRDLLQTNAKIFSEQGRVLGEVASPNCRVCVVGNPANTNALILLRESKGKLNPRFVTALTRLDHNRATAQVAERARARVEEVKNCIIWGNHSGTQVPDVNSATVGGKPARAAVDNGAFFDNEFITIVQERGAEIMKLRGLSSALSAAKAIVDHVHDWMLGTPSGTHVSMAVYSDGNPYGVPGGLIFSFPVTCSGGEWQIVSGLNVTPAISERIKATTTELEEERREVSTA
InterPro domains: - IPR001557: L-lactate/malate dehydrogenase (family) [2-328]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [5-154]
- IPR001236: Lactate/malate dehydrogenase, N-terminal (domain) [7-147]
- IPR022383: Lactate/malate dehydrogenase, C-terminal (domain) [158-323]
- IPR011274: Malate dehydrogenase, NAD-dependent, cytosolic (family) [4-324]
- IPR015955: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (homologous_superfamily) [157-328]
- IPR001252: Malate dehydrogenase, active site (active_site) [157-169]
- IPR010945: Malate dehydrogenase, type 2 (family) [5-324]
Interaction partners: - Citrate synthase
- fumarate hydratase
- Malic enzyme
- Malic enzyme
- fumarate hydratase
- Aspartate aminotransferase
- aspartate transaminase
- phosphoenolpyruvate carboxykinase
- NAD-specific glutamate dehydrogenase
- Malate dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0016615 (malate dehydrogenase activity), GO:0030060 (L-malate dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006108 (malate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)