wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Gastrin/cholecystokinin type B receptor (E9PIC8)
Organism: Homo sapiens (Human)
Function: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
InterPro domains: - IPR009126: Cholecystokinin receptor (family) [73-358]
- IPR000314: Gastrin receptor (family) [20-53]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [52-306]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [50-314]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0065008 (regulation of biological quality), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0007204 (positive regulation of cytosolic calcium ion concentration), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008284 (positive regulation of cell population proliferation), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Golgi SNAP receptor complex member 2 (A0A1W2PNV3)
Organism: Homo sapiens (Human)
Function: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network
Subcellular location: Endoplasmic reticulum membrane. Golgi apparatus, cis-Golgi network membrane; Single-pass type IV membrane protein
Sequence: IFSRLERLEILSSKEPPNKRQNARLRVDQLKYDVQHLQTALRNFQHRRHAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKVHNGMDDLILDGHNILDGLRTQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIAM
InterPro domains: - IPR027027: GOSR2/Membrin/Bos1 (family) [3-151]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0048193 (Golgi vesicle transport), GO:0006891 (intra-Golgi vesicle-mediated transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005773 (vacuole), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005770 (late endosome), GO:0005774 (vacuolar membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0031902 (late endosome membrane), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)
Protein: Proteasome activator subunit 3 interacting protein 1 (H3BNK9)
Organism: Homo sapiens (Human)
Sequence: XNGAKGGKKNGRKFENLKIQKVGISQENKKEVEKKLTVKPIETKNKFSQAKLLAGAVKHKSSESGNSVKRLKPDPEPDDKNQEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYSGSSDSESSSDSEGTINATGKIVSSIFRTNTFLEAP
InterPro domains: - IPR039845: PSME3-interacting protein (family) [14-129]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0010564 (regulation of cell cycle process), GO:0051983 (regulation of chromosome segregation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005654 (nucleoplasm), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Testis expressed 264, ER-phagy receptor (C9JXQ7)
Organism: Homo sapiens (Human)
Sequence: MSDLLLLGLIGGLTLLLLLTLLAFAGYSGLLAGVEVSAGSPPIRNVTVAYKFHMGLYGETGRLFTESCSISPKLRSIAVYYDNPHMVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDG
InterPro domains: - IPR011256: Regulatory factor, effector binding domain superfamily (homologous_superfamily) [42-193]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0042440 (pigment metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0042168 (heme metabolic process), GO:1901575 (organic substance catabolic process), GO:0046149 (pigment catabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0046700 (heterocycle catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0033013 (tetrapyrrole metabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033015 (tetrapyrrole catabolic process), GO:0006787 (porphyrin-containing compound catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: G patch domain-containing protein 4 (E9PAV9)
Organism: Homo sapiens (Human)
Sequence: MFPRSGPSNDEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000781 (chromosome, telomeric region), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome)
Protein: G patch domain-containing protein 4 (A0A0A0MRK1)
Organism: Homo sapiens (Human)
Sequence: MNVTPEVKSRGMKFAEEQLLKHGWTQGKGLGRKENGITQALRVTLKQDTHGVGHDPAKEFTNHWWNELFNKTAANLVVETGQDGVQIRSLSKETTRYNHPKPNLLYQKFVKMATLTSGGEKPNKDLESCSDDDNQGSKSPKILTDEMLLQACEGRTAHKAARLGITMKAKLARLEAQEQAFLARLKGQDPGAPQLQSESKPPKKKKKKRRQKEEEEATASERNDADEKHPEHAEQNIRKSKKKKRRHQEGKVSDEREGTTKGNEKEDAAGTSGLGELNSREQTNQSLRKGKKKKRWHHEEEKMGVLEEGGKGKEAAGSVRTEEVESRAYADPCSRRKKRQQQEEEDLNLEDRGEETFRWWNQGSREQSMQ
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0030154 (cell differentiation), GO:0048468 (cell development), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0030097 (hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000781 (chromosome, telomeric region), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005819 (spindle), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome), GO:0015630 (microtubule cytoskeleton), GO:0000793 (condensed chromosome)
Protein: FI02923p (Q9V9U1)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MSSLLNATVLATAATVVPDSQFVFNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTIPAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFILTMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFGGIKAVVWTDVIQAAIMVASVVLVGVLGAHRVGGFFEVLRIAGEGGRLDINYNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQRIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDTVGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRHTEHRANVIMKLFVFFTGIYCILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILSWGRNHYDTLPTSTSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEFSILDLSFNWYTVTGFVITWLIGIPLSYILKSGPDYKPNPKLLSPVVQPFVHYKLTPSDEPHQLNLEKPEKV
InterPro domains: - IPR038377: Sodium/glucose symporter superfamily (homologous_superfamily) [53-567]
- IPR051163: Sodium:Solute Symporter (SSF) (family) [23-572]
- IPR001734: Sodium/solute symporter (family) [25-475]
Interaction partners: - Vanin-like protein 1
- Biotinidase
- FI19428p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)
Protein: FI19713p1 (Q9W3V2)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Golgi apparatus
Sequence: MSWFEKAKTVLIEALDIQDDDSKAAEKDSPMAGAASDGGASPGNNATAETPGSAATPASDTPTFFDNPHANEMVTIPPTPTSVPGSAAYGKRQSATSDSVDLLSSPTSPISPCGGDVPSVAKRLSESSLELITATTASEVEMSPDTEPSLPDSIVIIASNDTSDNAEGDGEDDDDEGTQLKRHMEDHLNDSTKTMKALVLSDIQVAGNADSDSTQSFEDIQLQMSHKGKSPAPAKTGTVDQSYSSTSSDIEIISNPNGDSSTNSTTTRTSPQKFKELAGGKVCLKAKGHHREPSEISLLSEDSQSELDKLVQRISELNQVIEAREQRLLQSERQNAELLERNQELRARVEAAANSANSPDAADAVQRLSALEKKFQASIRERDALRIQMKSLRDELQNKIPRDELAECNEMIAALQSEGEKLSKEILQQSTIIKKLRAKEKTSDTLLKKNGEQISLLSSESERLKRSLAAKEEMERTQIEAVCRMTAEKKRVDEENAESRSRIEDLQSRLAALQASFDGLKGDLQKRTRLEQDSLRAEHQEYVQQVSDLREKLRLAEHSLARREQQMREENRQLMRRLEAAELRAESSTQELGATTTPLIRQIESLQRTLDQRSAAWNREEQQLLQKLDDSQVQLRSLQQLESVQGEKQELLRTRCGLLEEKLSSALMEAEAAKMALRQHDLEAANKENDHKKQLSLLQEEIQQQQERIASLEQLCQRQKEEEEQRKQPTLLTVKAVKASSELQPQLQMQLPKSQAPLRSSPPLSLVDDSGSNEEALGGMIDWQADDLDCASNSGRQQSGIIQGVHLSFLAANTTTFEHLQALLKQRDGELTHLQWEVSRLQAERSVLDAEISNLTIELETMKEKQQMYEVMEKGYEDLQHRYDALLQMYGEKVERTEELELDLTELKAAYKLQIDELLAAPPPNLQRPSKQT
InterPro domains: - IPR052602: Growth and transcription regulation protein (family) [1-921]
- IPR022092: TATA element modulatory factor 1 DNA binding (family) [403-472]
- IPR022091: TATA element modulatory factor 1, TATA binding (domain) [812-918]
Interaction partners: - Ras-related protein Rab6
- Centrosomin's beautiful sister, isoform A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0007163 (establishment or maintenance of cell polarity), GO:0022402 (cell cycle process), GO:0051640 (organelle localization), GO:0007049 (cell cycle), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0031023 (microtubule organizing center organization), GO:0007098 (centrosome cycle), GO:0051653 (spindle localization), GO:0051656 (establishment of organelle localization), GO:0051294 (establishment of spindle orientation), GO:0006996 (organelle organization), GO:0051293 (establishment of spindle localization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Insomniac, isoform B (Q9W579)
Organism: Drosophila melanogaster (Fruit fly)
Sequence: MSTVFINSRKSPNVLKKQGTDQWVKLNVGGTYFLTTKTTLSRDPNSFLSRLIQEDCDLISDRDETGAYLIDRDPKYFAPVLNYLRHGKLVLDGVSEEGVLEEAEFYNVTQLIALLKECILHRDQRPQTDKKRVYRVLQCREQELTQMISTLSDGWRFEQLISMQYTNYGPFENNEFLCVVSKECGTTAGRELELNDRAKVLQQKGSRILGI
InterPro domains: - IPR000210: BTB/POZ domain (domain) [22-123]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [14-122]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [24-112]
Interaction partners: - Cullin 3, isoform F
- Uncharacterized protein
- Dorsal interacting protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0008092 (cytoskeletal protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0017022 (myosin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0042752 (regulation of circadian rhythm), GO:0030431 (sleep), GO:0050795 (regulation of behavior), GO:0042749 (regulation of circadian sleep/wake cycle), GO:0045187 (regulation of circadian sleep/wake cycle, sleep)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0031463 (Cul3-RING ubiquitin ligase complex), GO:0005634 (nucleus)
Protein: Pickpocket 30, isoform A (Q9VAJ5)
Organism: Drosophila melanogaster (Fruit fly)
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MSATAWKPEPSSEDNDDDHKESKKKLKKEGAGGWASTRRYARIPLKIMAALATVYVSILSSERYFYYWVQTSIERTDMHVSEIDFPAVTIIPINLSILKAEKLSKAYNLVQSVVWQTPMSARLTDENFTEFSELENWNAQSWGIYQALQMNCQHFFTECQWRRKAMNCCDLFRPTKTFNGFAFEFNSLVSSGRDETWPWSVASCGSYSGLNVKIKRQQGLYTLNTMGVIVHEPTQLLGMSIDYSSEDRIVVPVEPLHFTAELDVRARPVQMRRCYFENEIPTGKSRSECIYKCHVNYIISKCNCSLELPVKATQDEDNIAAAKESNGRRICGVKDLACFNQHRLSLFSMSNIIEESRDNVFSTVDCGCFPQCGHTQYHTSTYTEKMSAHTNLAAAIEIDVYFQEETLFSYRSMLRFTLIDLMVSYGGIAGLIMGISVLGCINELLDRFACCRIPHGS
InterPro domains: - IPR001873: Epithelial sodium channel (family) [47-441]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015280 (ligand-gated sodium channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0050807 (regulation of synapse organization), GO:0099174 (regulation of presynapse organization), GO:2000331 (regulation of terminal button organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)