Protein: T-cell leukemia homeobox protein 1 (Homeobox TLX-1) (Homeobox protein Hox-11) (P43345)
Organism: Mus musculus (Mouse)
Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MEHLGPHHLHPGHAEPISFGIEQILNSPDQGGCMGPNSRLQDGDYGLGCLVPGAYTYGGGGSAAGAGAGGTGAYGAGGPGGPGGPAGGGGGACSMGPLPGSYNVNMDLAGGPGPGGDGGGGGAARRALSAAGVIRVPAHRPLAGAVAHPQPLATGLPTVPSVPAVPGVNNLTGLTFPWMESNRRYTKDRFTGLPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAESEQANRILLQLQQEAFQKSLAQPLPADPLCVHNSSLFALQNLQPWSDDSTKITSVTSVASACE
InterPro domains: - IPR001356: Homeodomain (domain) [201-265]
- IPR020479: Homeodomain, metazoa (domain) [225-259]
- IPR042247: T-cell leukemia homeobox protein 1/2/3 (family) [8-325]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [198-262]
- IPR017970: Homeobox, conserved site (conserved_site) [236-259]
Interaction partners: - Protein phosphatase EYA1
- Paired box protein Pax-2
- Rhombotin-1
- Protein lyl-1
- T-cell acute lymphocytic leukemia protein 1 homolog
- Rhombotin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0048736 (appendage development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0035107 (appendage morphogenesis), GO:0048568 (embryonic organ development), GO:0061035 (regulation of cartilage development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0033333 (fin development), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0035108 (limb morphogenesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0035137 (hindlimb morphogenesis), GO:0030326 (embryonic limb morphogenesis), GO:0048706 (embryonic skeletal system development), GO:0072498 (embryonic skeletal joint development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)