Protein: ADP,ATP carrier protein 2, mitochondrial (ADP/ATP translocase 2) (Adenine nucleotide translocator 2) (ANT 2) (P40941)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:14671022}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MVEQTQHPTILQKVSGQLLSSSVSQDIRGYASASKRPATYQKHAAYGNYSNAAFQYPLVAASQIATTTSPVFVQAPGEKGFTNFAIDFMMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKAGRLTEPYKGIRDCFGRTIRDEGIGSLWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDKDGYWKWFAGNLASGGAAGASSLLFVYSLDYARTRLANDSKSAKKGGGERQFNGLVDVYKKTLKSDGIAGLYRGFNISCAGIIVYRGLYFGLYDSVKPVLLTGDLQDSFFASFALGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSFDAFSQIVKKEGAKSLFKGAGANILRAVAGAGVLAGYDKLQLIVFGKKYGSGGA
InterPro domains: - IPR002113: ADP/ATP carrier protein, eukaryotic type (family) [71-384]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [82-376]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [81-381]
- IPR002067: Mitochondrial carrier protein (family) [87-319]
Interaction partners: - UPF0235 protein At5g63440
- Mitochondrial phosphate carrier protein 2, mitochondrial
- At1g09850
- Probable cysteine protease RD21B
- Cysteine proteinase RD21A
- Probable cysteine protease RD21C
- Mitochondrial phosphate carrier protein 3, mitochondrial
- Small ribosomal subunit protein mS75
- Mitochondrial succinate-fumarate transporter 1
- Mitochondrial substrate carrier family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:1901363 (heterocyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:0043169 (cation binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015215 (nucleotide transmembrane transporter activity), GO:0005347 (ATP transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015217 (ADP transmembrane transporter activity), GO:0003723 (RNA binding), GO:0005346 (purine ribonucleotide transmembrane transporter activity), GO:0046872 (metal ion binding), GO:0015297 (antiporter activity), GO:0003729 (mRNA binding), GO:0046914 (transition metal ion binding), GO:0015216 (purine nucleotide transmembrane transporter activity), GO:0000295 (adenine nucleotide transmembrane transporter activity), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015931 (nucleobase-containing compound transport), GO:0015748 (organophosphate ester transport), GO:0006862 (nucleotide transport), GO:0015865 (purine nucleotide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030312 (external encapsulating structure), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0005773 (vacuole), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0000325 (plant-type vacuole), GO:0009507 (chloroplast), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0009505 (plant-type cell wall), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0070013 (intracellular organelle lumen), GO:0005730 (nucleolus), GO:0009941 (chloroplast envelope), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)