Protein: Ubiquitin carboxyl-terminal hydrolase (D6WQP0)
Organism: Tribolium castaneum (Red flour beetle)
Function: Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK118ub1). Mediates bisymmetric organization of the PR-DUB complex and is involved in association with nucleosomes to mediate deubiquitination. Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys- 48'- and 'Lys-63'-linked polyubiquitin chains. Polycomb group (PcG) protein
Subcellular location: Nucleus
Sequence: MPVDIKELTEGWLELESDPGLFSLLLEDFGVKGVQVEEIYDIHKPLDGPVYGFIFLFRWMEERRSRRKIVEQTEVFVRDEEIVNDIFFAQQMVPNSCATHALVSVLLNCADLHLGATLERLRTHTRGMSPENKGWAIGNTPELAKAHNSHAMPQAKRRLDKSSGVSTGRFTGEAFHFVSFVPINGRLFELDGLKPWPIDHGPWNEGDQWTDKFRAVIADRLAISAGDEGSEIRFNLMAVVPDRRLAIHHKLKMLKTNRQIVLDALKHLVKVKKDKKEETASNNAMEEDPPQGNSQSQSASEEGALTPKSSVTTLGPLDYATPLTIQTSPAPSTSGTDTSSEIGSAFNSPTQTWNWGAQQQQPSPSSRDLKRFVVIRMNEQEEEQNSKKTVKKEGTEQKSNGNGGVARVRTSDGDTVVAEKKHPELLEPHTFAPQDLLALLRNLENEICMCEINLKDENDKQNKYKIDDCRRTHNYDEFICTFLSMLAEQGKLADLVEQHLQVPKRPGTVPQPKAAKTAKKHETGATKRKKGRTKVKRRR
InterPro domains: - IPR001578: Peptidase C12, ubiquitin carboxyl-terminal hydrolase (domain) [10-375]
- IPR041507: Peptidase C12, C-terminal domain (domain) [449-492]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [9-242]
- IPR036959: Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily (homologous_superfamily) [4-244]
Interaction partners: - 26S proteasome non-ATPase regulatory subunit 4
- DEUBAD domain-containing protein
- 26S proteasome non-ATPase regulatory subunit 8
- Fibronectin type-III domain-containing protein
- 26S proteasome non-ATPase regulatory subunit 14
- Proteasomal ubiquitin receptor ADRM1 homolog
- 26S proteasome non-ATPase regulatory subunit 7
- 26S proteasome non-ATPase regulatory subunit 11-like Protein
- Proteasome subunit alpha type
- 26S protease regulatory subunit 4-like Protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0019783 (ubiquitin-like protein peptidase activity), GO:0101005 (deubiquitinase activity), GO:0004843 (cysteine-type deubiquitinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070646 (protein modification by small protein removal), GO:0070647 (protein modification by small protein conjugation or removal), GO:0016579 (protein deubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)