Protein: Cytochrome bo(3) ubiquinol oxidase subunit 2 (Cytochrome b562-o complex subunit II) (Cytochrome o ubiquinol oxidase subunit 2) (Cytochrome o subunit 2) (Oxidase bo(3) subunit 2) (Ubiquinol oxidase chain B) (Ubiquinol oxidase polypeptide II) (Ubiquinol oxidase subunit 2) (P0ABJ1)
Organism: Escherichia coli (strain K12)
Function: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}; Multi-pass membrane protein {ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:6365921}.
Sequence: MRLRKYNKSLGWLSLFAGTVLLSGCNSALLDPKGQIGLEQRSLILTAFGLMLIVVIPAILMAVGFAWKYRASNKDAKYSPNWSHSNKVEAVVWTVPILIIIFLAVLTWKTTHALEPSKPLAHDEKPITIEVVSMDWKWFFIYPEQGIATVNEIAFPANTPVYFKVTSNSVMNSFFIPRLGSQIYAMAGMQTRLHLIANEPGTYDGISASYSGPGFSGMKFKAIATPDRAAFDQWVAKAKQSPNTMSDMAAFEKLAAPSEYNQVEYFSNVKPDLFADVINKFMAHGKSMDMTQPEGEHSAHEGMEGMDMSHAESAH
InterPro domains: - IPR011759: Cytochrome C oxidase subunit II, transmembrane domain (domain) [21-118]
- IPR008972: Cupredoxin (homologous_superfamily) [113-282]
- IPR045187: Cytochrome c/quinol oxidase subunit II (family) [23-242]
- IPR036257: Cytochrome C oxidase subunit II, transmembrane domain superfamily (homologous_superfamily) [27-116]
- IPR002429: Cytochrome c oxidase subunit II-like C-terminal (domain) [124-237]
- IPR006333: Cytochrome o ubiquinol oxidase subunit II (family) [1-313]
- IPR034227: Ubiquinol oxidase subunit 2, cupredoxin domain (domain) [127-225]
- IPR010514: COX aromatic rich motif (domain) [239-285]
Interaction partners: - Cytochrome bo
- Protoheme IX farnesyltransferase
- Cytochrome bo
- Cytochrome bo
- NADH-quinone oxidoreductase subunit H
- NADH-quinone oxidoreductase subunit C/D
- NADH-quinone oxidoreductase subunit M
- Succinate dehydrogenase cytochrome b556 subunit
- NADH-quinone oxidoreductase subunit N
- Cytochrome bd-I ubiquinol oxidase subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0009060 (aerobic respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:1990204 (oxidoreductase complex), GO:0005886 (plasma membrane)