Protein: Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] (Q71U36)
Organism: Homo sapiens (Human)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:P68369}.
Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
InterPro domains: - IPR036525: Tubulin/FtsZ, GTPase domain superfamily (homologous_superfamily) [1-268]
- IPR023123: Tubulin, C-terminal (homologous_superfamily) [384-436]
- IPR008280: Tubulin/FtsZ, C-terminal (homologous_superfamily) [246-437]
- IPR018316: Tubulin/FtsZ, 2-layer sandwich domain (domain) [248-393]
- IPR000217: Tubulin (family) [2-439]
- IPR002452: Alpha tubulin (family) [18-438]
- IPR017975: Tubulin, conserved site (conserved_site) [142-148]
- IPR003008: Tubulin/FtsZ, GTPase domain (domain) [3-246]
- IPR037103: Tubulin/FtsZ-like, C-terminal domain (homologous_superfamily) [269-383]
Interaction partners: - Tubulin beta-3 chain
- Tubulin beta-2A chain
- Tubulin beta-4B chain
- Tubulin beta-2B chain
- Tubulin beta chain
- Cytoplasmic dynein 1 heavy chain 1
- Tubulin beta-6 chain
- Tubulin beta-4A chain
- Microtubule-associated protein tau
- CAP-Gly domain-containing linker protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005198 (structural molecule activity), GO:0097367 (carbohydrate derivative binding), GO:0005200 (structural constituent of cytoskeleton), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0019899 (enzyme binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0003723 (RNA binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0031625 (ubiquitin protein ligase binding), GO:0003725 (double-stranded RNA binding), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0007017 (microtubule-based process), GO:0051641 (cellular localization), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0046907 (intracellular transport), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006810 (transport), GO:0006996 (organelle organization), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)