Protein: E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (B9EKI5)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFSIPMLDLDDDDDREESLMMNRLASVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPERPPPIPPDNRLSRHFHHGESVPSRDQPMPLEAWCPRDAFGTNQVMGCRILGDGSPKPGVTANSSLNGRHSRMGSEQVLMRKHRRHDLPSEGAKVFSNGHLATEEYDVPPRLSPPPPVTTLLPSIKCTGPLANCLSEKTRDTVEDDDDEYKIPSSHPVSLNSQPSHCHNVKAPVRSCDNGHCILNGTHGAPSEMKKSNIPDLGIYLKGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFFDPTSGQVPLPPARRAAGDSGKANRASQDYDQLPSSSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL
InterPro domains: - IPR015940: Ubiquitin-associated domain (domain) [887-926]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [388-397]
- IPR014741: Adaptor protein Cbl, EF hand-like (domain) [171-254]
- IPR024162: Adaptor protein Cbl (family) [20-564]
- IPR039520: E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass (domain) [351-426]
- IPR018957: Zinc finger, C3HC4 RING-type (domain) [373-411]
- IPR011992: EF-hand domain pair (homologous_superfamily) [171-255]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [256-342]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [343-427]
- IPR024159: Adaptor protein Cbl, PTB domain (domain) [35-343]
- IPR014742: Adaptor protein Cbl, SH2-like domain (domain) [248-344]
- IPR003153: Adaptor protein Cbl, N-terminal helical (domain) [42-167]
- IPR036537: Adaptor protein Cbl, N-terminal domain superfamily (homologous_superfamily) [34-169]
- IPR001841: Zinc finger, RING-type (domain) [373-412]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0005102 (signaling receptor binding), GO:0017124 (SH3 domain binding), GO:0046875 (ephrin receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010640 (regulation of platelet-derived growth factor receptor signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0046578 (regulation of Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0098797 (plasma membrane protein complex), GO:0005794 (Golgi apparatus), GO:0098590 (plasma membrane region), GO:0098857 (membrane microdomain), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0045121 (membrane raft), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0044853 (plasma membrane raft), GO:0005901 (caveola)