Protein: Thiol-dependent reductase 1 (A4I8P2)
Organism: Leishmania infantum
Function: Not known
Sequence: MAARALKLYVSATCPFCHRVEIVAREKQVSYDRVAVGLREEMPQWYKQINPRETVPTLEVGNADKRFMFESMLIAQYLDNSGAPAGALMGSSAAQRHQIEFFLAQVGDFIGAAHGLLRDPLSGEKRKAMDDNAAYVDGLLAANQTTGPYYCDGEFTMADVALVPFLVRLKPALMYYAGYDVFCKAPRMKALWAAAAQRASVRETSPTAAQCIENYRHLVPESAPMMGANGGHVLYSNLFCPFVDRARLASELRKFQMHIVEVPLHPQPEWYKYINPRDTVPALFTPSGEAVHESQLIVQYIDCVATKGSALVPRGDAEKEYEVGFFVENAGYFVGGLMSWIIRGGEDAKAELQWAAGELEQQLAKHPFGEGPFFGGKRMNAGDVAILPFLVRAKAFMPEFSGGYDLFAHFPLLNGLAEAGMATPEAKSVFRTLEEYKEHIRKRQRRAQSG
InterPro domains: - IPR011767: Glutaredoxin active site (active_site) [8-23]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [6-302]
- IPR050983: Glutathione S-transferase Omega/HSP26 (family) [3-225]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [84-445]
- IPR041695: Glutathione S-transferase, C-terminal domain (domain) [97-429]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [92-444]
- IPR040079: Glutathione transferase family (family) [6-197]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [4-302]
Interaction partners: - Uncharacterized protein
- Putative As/Sb Reductase
- NADH-ubiquinone oxidoreductase 20 kDa subunit,mitochondrial
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH:ubiquinone oxidoreductase 78 Kd subunit-like protein
- Putative NADH-ubiquinone oxidoreductase, mitochondrial
- non-specific serine/threonine protein kinase
- Mitochondrial carrier protein-like protein
- non-specific serine/threonine protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0000166 (nucleotide binding), GO:0015036 (disulfide oxidoreductase activity), GO:0070402 (NADPH binding), GO:0016672 (oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor), GO:0017076 (purine nucleotide binding), GO:0015038 (glutathione disulfide oxidoreductase activity), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0009404 (toxin metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009636 (response to toxic substance), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:0043385 (mycotoxin metabolic process), GO:0046222 (aflatoxin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)