Protein: Protein vav (DroVav) (dVAV) (Q9NHV9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development.
Sequence: MASSSSSNSFGGVAGVNGDLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQKLASEEL
InterPro domains: - IPR000219: Dbl homology domain (domain) [216-396]
- IPR036872: CH domain superfamily (homologous_superfamily) [17-189]
- IPR001849: Pleckstrin homology domain (domain) [432-543]
- IPR035031: Vav, SH2 domain, invertebrate (domain) [616-726]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [721-788]
- IPR001452: SH3 domain (domain) [726-788]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [552-601]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [605-729]
- IPR037832: Vav, PH domain (domain) [416-545]
- IPR055251: SOS1/NGEF-like, PH domain (domain) [429-538]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [211-412]
- IPR001715: Calponin homology domain (domain) [18-137]
- IPR000980: SH2 domain (domain) [620-726]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [416-547]
Interaction partners: - Growth factor receptor-bound protein 2
- E3 ubiquitin-protein ligase CBL
- Ras-related protein Rac1
- RH14395p
- Epidermal growth factor receptor
- Tyrosine-protein kinase Btk
- Ras-like GTP-binding protein Rho1
- AT17867p
- Cdc42 homolog
- Ras-related protein Rac2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040011 (locomotion), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0016203 (muscle attachment), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051707 (response to other organism), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0030029 (actin filament-based process), GO:0051094 (positive regulation of developmental process), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0043207 (response to external biotic stimulus), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0050803 (regulation of synapse structure or activity), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0009886 (post-embryonic animal morphogenesis), GO:0051128 (regulation of cellular component organization), GO:0007412 (axon target recognition), GO:0051962 (positive regulation of nervous system development), GO:0006935 (chemotaxis), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0048639 (positive regulation of developmental growth), GO:0009967 (positive regulation of signal transduction), GO:0048736 (appendage development), GO:0051130 (positive regulation of cellular component organization), GO:0035107 (appendage morphogenesis), GO:0016319 (mushroom body development), GO:0030036 (actin cytoskeleton organization), GO:2000026 (regulation of multicellular organismal development), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0010647 (positive regulation of cell communication), GO:0030030 (cell projection organization), GO:0050807 (regulation of synapse organization), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0048666 (neuron development), GO:0007420 (brain development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0048737 (imaginal disc-derived appendage development), GO:0007417 (central nervous system development), GO:1902533 (positive regulation of intracellular signal transduction), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0008582 (regulation of synaptic assembly at neuromuscular junction), GO:0007444 (imaginal disc development), GO:0048858 (cell projection morphogenesis), GO:1901890 (positive regulation of cell junction assembly), GO:0031344 (regulation of cell projection organization), GO:1901888 (regulation of cell junction assembly), GO:0035120 (post-embryonic appendage morphogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0031532 (actin cytoskeleton reorganization), GO:0051960 (regulation of nervous system development), GO:1904398 (positive regulation of neuromuscular junction development), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:0051965 (positive regulation of synapse assembly), GO:0007422 (peripheral nervous system development), GO:0048569 (post-embryonic animal organ development), GO:0045887 (positive regulation of synaptic assembly at neuromuscular junction), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:1902531 (regulation of intracellular signal transduction), GO:0007478 (leg disc morphogenesis), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:1904396 (regulation of neuromuscular junction development), GO:0051057 (positive regulation of small GTPase mediated signal transduction), GO:0007010 (cytoskeleton organization), GO:0051963 (regulation of synapse assembly), GO:0007411 (axon guidance), GO:0048699 (generation of neurons), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007480 (imaginal disc-derived leg morphogenesis), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0035218 (leg disc development), GO:0046578 (regulation of Ras protein signal transduction), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0046579 (positive regulation of Ras protein signal transduction), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0035023 (regulation of Rho protein signal transduction), GO:0035025 (positive regulation of Rho protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction), GO:0005912 (adherens junction)