wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: GH28017p (Q8T0I5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MDCNRILRIAASFLTAPMVKLLLWTAHQELLLVQHHWYVCTRIWPNADRELEQYEMIPPAPVRMSDLNTKILTNTRLGYPALPFDDLGCPPGTRGLRPHPHDVHKYLRCGIGVKPQVEQCPRGHIFDGSSSVCVYSDSPRTSSSSFTSAEIQVNYLLCPVGAVGQFVHPFDQTKFLSCKDGKSAVQNCQPNYVFSISRRYCQLKAQLAFTDYVTLIISEISYEYSLILNACPGNINGIFLYPYDAKKYVQCSSGGRMSILSCGPQMAFSVSQRSCLPSHQVHISDRVQFWQEVQVQTTYTSQDLRGNVQSQLSSLRSCPPNVQKNYPYPFHAGHYVRCQYGALEIICCPTGQLYSLSQRQCVPRSLLSAHDYLDYSYISAELSTEFMVDRSTLSCPPQAQGLYLHPFDCTKYVRCWNQQTFIESCVVCAYAILRTIK
InterPro domains: - IPR036508: Chitin binding domain superfamily (homologous_superfamily) [82-425]
- IPR002557: Chitin binding domain (domain) [86-435]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0007610 (behavior), GO:0050877 (nervous system process), GO:0007611 (learning or memory), GO:0007613 (memory), GO:0050890 (cognition), GO:0007616 (long-term memory), GO:0007614 (short-term memory)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0007610 (behavior), GO:0007611 (learning or memory), GO:0050877 (nervous system process), GO:0007613 (memory), GO:0050890 (cognition), GO:0007616 (long-term memory), GO:0007614 (short-term memory)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure)
Protein: SET domain-containing protein (Q57Y34)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MNEQLRVALESVEPQAGSSLQAEEVQSTIRKKEMFAPRIATLAAVAPLAEEELPPAVYRKPKFSFLSDPSERHPPDALSVYEVPNNSPKAPLPMWASSLTSPQLGRQRIRVENWISTDSMGTVPEDHVQDFLAWFREELIKSSQTVLWNMLTDNVDFHLRSQYSRGLVARKPFHKGDMIFAVPLYGALGADSADEFVPSSPAPSVASEGNLTPWSLTINSENLQRHSVAAQRRGVPSYQSVEAIVGQRKSSFDPLPHPLFVDQVHFALLLACERAEGAKSPLFSYLRLLSPFDDDFIRELHLGVLDPATHLEYTDHCGRFSHYLRQIRNRWQQEYESAVCSGAGEVSSVDGSVSPNDGNDVVNARSPIEEGKTQCTTPGRLPPPSMDDLTWALRVVLSRQRLLPLRRHTEHFEDICSEEKVLQKLHLWTRLITKMHMGVMDNIFRVVDRNRVGVNDFQPHTIATIVPIVDMLQHPPGGMSNTSCSIEKISLSNDSNKVANTAGMCKEAVCAVVRANSRIEEGDELTQLYPRCYSVSYTLYRFGFLPLRRRAGDAADAVLRTQR
InterPro domains: - IPR046341: SET domain superfamily (homologous_superfamily) [126-546]
- IPR050600: SETD3/SETD6 methyltransferase (family) [98-545]
Interaction partners: - Peptidyl-prolyl cis-trans isomerase
- NADH dehydrogenase 1 alpha subcomplex subunit 13
- NADH-ubiquinone oxidoreductase complex I subunit
- NADH-ubiquinone oxidoreductase complex I subunit
- Uncharacterized protein
- Adrenodoxin reductase, putative
- NB-ARC domain-containing protein
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase subunit NI8M
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:1901564 (organonitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:0018193 (peptidyl-amino acid modification), GO:0018205 (peptidyl-lysine modification), GO:0018023 (peptidyl-lysine trimethylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Probable membrane protein (O53962)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MFPRWPQQAHNHEVSRADTVSVPRAPTQAEVAAVLRIMTPLRKVIKPKVYGIENVPTERALLVGNHNTLGLVDAPLLAAELWERGRIVRSLGDHAHFKIPGWRDALTRTGVVEGTREITSELMRRGELVMVFPGGAREVNKRKNERYKLVWKNRLGFARLAIQHGYPIVPFASVGAEHGIDIVLDNESPLLAPVQFLAEKLLGTKDGPALVRGVGLTPVPRPERQYYWFGEPIDTTEFMGQQADDNAARRVRERAAAAIEHGIELMLAERAADPNRSLVGRLLRSDA
InterPro domains: - IPR016676: Phospholipid/glycerol acyltransferase, predicted (family) [5-276]
- IPR002123: Phospholipid/glycerol acyltransferase (domain) [47-176]
Interaction partners: - Conserved protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Dem-like protein (Putative Dem protein) (Vacuolar import/degradation, Vid27-related protein) (Q9SZB7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MGASHSHEDLEICSSDEDEYEEYEEGREGEEEEETFQDSRDDTLGISSSGGRRLRPKSPSSSLDDVEAKLQALKLKYPLTQSAPSTQNSARLFRYINGNTPKAKWVTAEKLTAYCFVKTNKGDEDDEDDDENGDVENEWWILKVGSKIREKVSDEMQLKAYKDQRRVDFVAKAVWAMKFASSEDFSVFVSSYNNCLFENNHGVEFNEANKAKIYGKDFIGWANPEAADDSMWEDADDILLQSPGGGSATPARDTQDLTEAFEEATSEGIHSLALGALDNSFLVGDSGIQVFKNMRQGIQGKGVCVNFEPGYGRTHSSAPKKALLMRAETNMLLMSPMSQTPHSRGIHQLDIETGKIISEWKFEKDGVDISMSDITNDGKGAQLDPSASTFLGLDNNRLCRWDMRDRYGMVQDLATANTPVLNWAQGHQFSRGTNFQCFATTGDGSIVVGSLDGKIRLYSSNTMRQAKTAFPGLGAPVTHVDATFDGKWIVGTTDTYLIVICTLFTDKSGKTKTGFEGRMGNKIAAPRLLKLRPLDAHLAGSDNKFRNAQFSWVTEDGKQERHVVATVGKFSVIWNFQQVKNGSHECYHDQEGLKKCYCYKIVLRNESIVDSRFMNDNFAISGSPEAPLVIATPMKVSSFSLSSKR
InterPro domains: - IPR055559: CYPRO4-like, N-terminal DUF7135 (domain) [54-215]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [345-600]
- IPR013863: Vacuolar import/degradation Vid27, C-terminal (domain) [272-588]
- IPR040458: Vacuolar import/degradation Vid27 (family) [1-643]
Interaction partners: - Uveal autoantigen with coiled-coil/ankyrin
- Nuclear protein
- Phospholipase A1-IIdelta
- Kunitz trypsin inhibitor 2
- soluble epoxide hydrolase
- AT2G24420 protein
- Peroxisomal membrane protein 13
- GTP-binding nuclear protein Ran-1
- GDSL esterase/lipase ESM1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0051236 (establishment of RNA localization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006403 (RNA localization), GO:0043170 (macromolecule metabolic process), GO:0071702 (organic substance transport), GO:0050658 (RNA transport), GO:0051169 (nuclear transport), GO:0071705 (nitrogen compound transport), GO:0010467 (gene expression), GO:0015931 (nucleobase-containing compound transport), GO:0006913 (nucleocytoplasmic transport), GO:0051028 (mRNA transport), GO:0006406 (mRNA export from nucleus), GO:0006405 (RNA export from nucleus), GO:0051168 (nuclear export), GO:0050657 (nucleic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Fasciclin domain family protein (AFU_orthologue AFUA_1G14300) (Q5BFB2)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MKLQLHLTLAGLFCSVLAIQDVLSEVKDSRNGLLEAGAKNPLDSALELSPTFSPAEIFDTTEITKYLNSINVDTIPNTDSWISGFLASNLFNEITNAPSDFVNEIDARTETHPIQSDKTIYQLISESKYTNILAKIIDQDPKLVEFLNSTHHKITVFAPTDDAFRKILHHHHHRHHDGHDGNGHERDGDGDKDHHIPKEVIRYFASYHSSPEILTAAKLFHAHTVNSALNDSLLGTDKHDNGLPQRLAVRAGFKGLTINFYSHVVAADIGASNGLIHGLDSILLPPPPALLLLDILPTKFSTFNLGLIKTGLTQYLNTTKEESAHGFTIFTPSNRAFDHLGLRINAFLFSPYGIPYLRALLKYHIVPNQTLYSDVLYTSDGQIKPFGVKGSTHLDLETLLDDHEISVDVARFGPYTGFKVNGWQRVAFADVLGKDGVIHVLNRVLIPPKRVEGKVIFGDEGELELEEFMERLRPWVEEDVGNEKSDGYATDL
InterPro domains: - IPR000782: FAS1 domain (domain) [117-448]
- IPR036378: FAS1 domain superfamily (homologous_superfamily) [94-449]
- IPR050904: Cell adhesion and biosynthesis-related protein (family) [106-451]
Interaction partners: - Transcription factor domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0006950 (response to stress), GO:0009991 (response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0033554 (cellular response to stress), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Possible acyltransferase (O07807)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MEPVYGTVIRLARLSWRIQGLKITVTGVDNLPTSGGAVVAINHTSYLDFTFAGLPAYQQGLGRKVRFMAKQEVFDHKITGPIMRSLRHIPVDRQDGSASYDAAVRMLKAGELVGVYPEATISRSFEIKEFKTGAARMAIEAGVPIVPHIVWGAQRIWTKDRPKKLFRPKVPVTIVVGERIEPTLPTAELNGLLHSRMQHLLERAQELYGPHPAGEFWVPHRLGGGAPSLAEAARLDAQEAAVRAARRAQRAHPAGAPEQ
InterPro domains: - IPR002123: Phospholipid/glycerol acyltransferase (domain) [22-153]
Interaction partners: - Possible acyltransferase
- Conserved protein
- Possible acyltransferase
- Possible phosphotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity), GO:0071617 (lysophospholipid acyltransferase activity), GO:0016411 (acylglycerol O-acyltransferase activity), GO:0042171 (lysophosphatidic acid acyltransferase activity), GO:0003841 (1-acylglycerol-3-phosphate O-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1903509 (liposaccharide metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0009247 (glycolipid biosynthetic process), GO:0006664 (glycolipid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein hook homolog (DdHk3) (Q54IK9)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Cytoskeletal linker protein involved in tethering membrane bound organelles to the cytoskeleton.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}.
Sequence: MIETSFIKWINSFKDLSNSIEDLKELSNGTIFNEICCQIAPKYFDIDSLRKDGLDNWIFREENIKNIVERVDEFYIEEMGLNDQISSINCEEIANENIDEIILLIEAILGMAMESENNEAVIENILSLDQDTQNDLMVVVAKIQQSHQPNTVDNSKSFDKDGSILSQSPSQSNNSISNNNNNNNIDSSNISKSNISSNNNNNNSSNNNKEEILNLQNEIEKLKREKQEIQNDLDESNIQLSNVTMDRDRITIDKQKTEEVCSSLHESIIGLQKQLDETMAQTTTMNALNDETYKTEINDLHMQVESKEKQLSELKKKVDEANRLANENRSLRDEIDILREKAANAEATEEKLKKHQKKIEEIGDLKKKIKELEDQNDSYIQQTLDLEEQLSKNNTYRTQADSGKQQISSLKIELAKLELSLKSIKEDRDKLSESLNTVELERDSLQSQVTNLRNTIDNQQQEYETKFVDLQSSISLNSGGSGGLGDEVIDGSTKERIARLERDNKRLKEVAEKASELENQLEDANQSKELLTIQIKQLEEQKQQSNNTNNNNNNNNMVDSSEIESLKQQLKEKEKEISTLKRKLEESNLSLDENRKQLVELSQRPTTQSPGDIEKLENYENLLKENDGLEGRLRAARNIIKDLREKHKSYSNQETQLATKDEVITKLEGLVKKKTDINEDLRKQLEEGREESQREINLMLSAFLKIGLEMEQVKIQNISSSKEPRSFLNKKRAD
InterPro domains: - IPR001715: Calponin homology domain (domain) [1-113]
- IPR008636: Hook, C-terminal (domain) [283-732]
- IPR036872: CH domain superfamily (homologous_superfamily) [1-145]
- IPR043936: HOOK, N-terminal (domain) [4-138]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0007059 (chromosome segregation), GO:0006810 (transport), GO:0031023 (microtubule organizing center organization), GO:0007098 (centrosome cycle), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005813 (centrosome), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Dye-decolorizing peroxidase AauDyP1 (EC 1.11.1.19) (EC 1.11.1.7) (AjP I) (Manganese-independent peroxidase I) [Cleaved into: Dye-decolorizing peroxidase AauDyP2 (EC 1.11.1.19) (EC 1.11.1.7) (AjP II) (Manganese-independent peroxidase II)] (I2DBY1)
Organism: Auricularia auricula-judae (Judas ear fungus) (Tremella auricula-judae)
Function: Manganese-independent peroxidase that is able to convert a large number of compounds, but its physiological substrate is not known. In addition to classic peroxidase substrates (e.g. 2,6-dimethoxyphenol), oxidizes dyes such as Reactive Blue 5 and Reactive Black 5.
Subcellular location: Secreted {ECO:0000305|PubMed:23111597}.
Sequence: MRLSPVFVALLSGLLAADLGLARSVAPRVADSPAAVTGTRKTSLLKNVAGLPPVPSAAQVAATSLNTDDIQGDILVGMHKQKQLFYFFAINDPATFKTHLASDIAPVVASVTQLSNVATQPLVALNIAFSNTGLLALGVTDNLGDSLFANGQAKDATSFKESTSSWVPQFAGTGIHGVIILASDTTDLIDQQVASIESTFGSSISKLYSLSASIRPGNEAGHEMFGFLDGIAQPAINGFNTPLPGQNIVDAGVIITGATNDPITRPSWAVGGSFLAFRQLEQLVPEFNKYLLDNAPAGSGSLQARADLLGARMVGRWKSGAPIDLTPTADDPALGADAQRNNNFTYSHAGFDLGSDQSHCPFSAHIRKTRPRADLGGSLTPPNLSAGANSIMRSGIPYGPEVTSAESASNTTTQERGLAFVAYQAQLSQGFHFLQQTWADNANFPPGKTPATVGLDPIIGQNNGQPRVVNGLLPSNSSASLSIPQFVVSHGGEYFFSPPISAIGGRLSA
InterPro domains: - IPR011008: Dimeric alpha-beta barrel (homologous_superfamily) [65-505]
- IPR048328: Dyp-type peroxidase, C-terminal domain (domain) [267-440]
- IPR049509: DyP dimeric alpha+beta barrel domain (domain) [69-216]
- IPR006314: Dyp-type peroxidase (family) [69-506]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004601 (peroxidase activity), GO:0016491 (oxidoreductase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0120252 (hydrocarbon metabolic process), GO:0006629 (lipid metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0016042 (lipid catabolic process), GO:0120253 (hydrocarbon catabolic process), GO:0046247 (terpene catabolic process), GO:0016119 (carotene metabolic process), GO:0008300 (isoprenoid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: peptidylprolyl isomerase (EC 5.2.1.8) (Q387V4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MYGVECFRPLGLAAFMLAVLSVVRVATSEDDPNKLTPQERIDRYRKRVARSFLLKMAEEPGAMTLPSGVVVHVLNRGGGGRSAAVDDECTVHYTGTLKDGTVFDSSRDRGQPFKLKLGQVIVGWQEVLQLMRPGDRWKVFIPPEHGYGARGAGPKIPPHSALVFDMELISIEGGGNGRTEKEVEEVLKGYAGKGDL
InterPro domains: - IPR046357: Peptidyl-prolyl cis-trans isomerase domain superfamily (homologous_superfamily) [33-193]
- IPR001179: FKBP-type peptidyl-prolyl cis-trans isomerase domain (domain) [81-172]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chordin-like protein 1 (Neuralin-1) (Neurogenesin-1) (Ventroptin) (Q920C1)
Organism: Mus musculus (Mouse)
Function: Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Sequence: MDGMKYIISLFFIFVFLEGSKTEQVKHSDTYCVFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPSLHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDAELSWEHADGDIFRQPANREARHSYLRSPYDPPPNRQAGGLPRFPGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPEEPPSQNFDSKGSFCGEETMPVYESVFMEDGETTRKVALETERPPQVEVHVWTIQKGILQHFHIEKISKRMFGELHHFKLVTRTTLNQWKLFTEGEAQLSQMCSSQVCRTELEDLVQVLYLGRPEKDHC
InterPro domains: - IPR045717: Chordin-like protein 1/2 (family) [3-447]
- IPR045716: Chordin-like protein 1/2, C-terminal (domain) [328-447]
- IPR001007: VWFC domain (domain) [30-318]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0045165 (cell fate commitment), GO:0001709 (cell fate determination), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)