Protein: GTP-binding protein YPT32/YPT11 (Rab GTPase YPT32) (P51996)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Required for protein transport through the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Mediates the proper polarized localization of SEC2, a GEF for SEC4, but does not alter the exchange activity of SEC2 on SEC4. Plays a role in autophagy.
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:9151665}; Lipid-anchor {ECO:0000269|PubMed:9151665}.
Sequence: MSNEDYGYDYDYLFKIVLIGDSGVGKSNLLSRFTTDEFNIESKSTIGVEFATRTIEVENKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYENCNHWLTELRENADDNVAVGLIGNKSDLAHLRAVPTDEAKNFAMENQMLFTETSALNSDNVDKAFRELIVAIFQMVSKHQVDLSGSGTNNMGSNGAPKGPTISLTPAPKEDKKKKSSNCC
InterPro domains: - IPR001806: Small GTPase (family) [1-222]
- IPR005225: Small GTP-binding domain (domain) [12-168]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [7-222]
- IPR050209: Rab GTPases family involved in membrane trafficking (family) [9-211]
Interaction partners: - Rab guanine nucleotide exchange factor SEC2
- GTPase-activating protein GYP1
- Vacuolar morphogenesis protein 6
- Myosin-2
- GTP-binding protein YPT31/YPT8
- Trafficking protein particle complex II-specific subunit 130
- Trafficking protein particle complex II-specific subunit 120
- Phosphatidylinositol 4-kinase PIK1
- Trafficking protein particle complex subunit BET3
- Trafficking protein particle complex subunit BET5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0140352 (export from cell), GO:0051649 (establishment of localization in cell), GO:0032940 (secretion by cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0016482 (cytosolic transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis), GO:0016197 (endosomal transport), GO:0042147 (retrograde transport, endosome to Golgi), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0019867 (outer membrane), GO:0098791 (Golgi apparatus subcompartment), GO:0005794 (Golgi apparatus), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0005802 (trans-Golgi network), GO:0031968 (organelle outer membrane), GO:0031982 (vesicle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane), GO:0097708 (intracellular vesicle)