Protein: Agglutinin-like protein 7 (Q5A312)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted, cell wall. Note=Identified as covalently-linked GPI-modified cell wall protein (GPI-CWP) in the outer cell wall layer
Sequence: MKKLYLLYLLASFTTVISKEVTGVFNQFNSLIWSYTYRARYEEISTLTAKAQLEWALDGTIASPGDTFTLVMPCVYKFMTYETSVQLTANSIAYATCDFDAGEDTKSFSSLKCTVTDELTEDTSVFGSVILPIAFNVGGSGSKSTITDSKCFSSGYNTVTFFDGNNQLSTTANFLPRRELAFGLVVSQRLSMSLDTMTNFVMSTPCFMGYQSGKLGFTSNDDDFEIDCSSIHVGITNEINDWSMPVSSVPFDHTIRCTSRALYIEFKTIPAGYRPFVDAIVQIPTTEPFFVKYTNEFACVNGIYTSIPFTSFFSQPILYDEALAIGADLVRTTSTVIGSITRTTTLPFISRLQKTKTILVLEPIPTTTVTTSHHGFDTWYYTKKATIGDTATVFIDVPQHTATTLTTYWQESSTATTTYFDDIDLVDTVIVKIPYPNPTIITTQFWSGKYLTTETHKEPPLGTDSVIIKEPHNPTVTTTEFWSESFATTETITNNPEGTDSVIIKEPHNPTVTTTKFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQDSSSSVEQSFTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYSSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQEISSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSFSFITSTVEISSDSVSLTSDPASSFDSSSRLNSDSSSSPSTDQRDILTSSSFSTLIKSSESRESSSGTILSEESSDSIPTTFSTRYWSPSGMSSRHYTNSTETSVSDVVSSSVAGDETSESSVSVTSESSESVTSESVASESVTSESVTAVSDISDLYTTSEEVSTSDSNSGMSSPIPSSEQRSSIPIMSSSDESSESRESSIGTILSEESSDSIPTTFSTRYWSPSGMSSRHYTNSTETSVSDVVSSSVAGDETSESSVSVISESSESVTSESVASESVTAVSDISDLYTTSEVVSTSDSKIVPSTSVPSSEQRSSIPIMSSSDESSESRESSSGTILSEENSDSIPTTFSTRYVSVSLTVGELSALPSLPGKLSHLPSSLSETSIGMTKSANLSPQFFSTSVDSALSYWASGSSSADHQSSATCDVSESSVEGNLSAMALGMSNSDDGLSEDTRSSSVAGKEEIELTSTNSVGEITLISYSSSSPTTHDHGRVSKSMGAAPLSSLFSVSVHAPLVTGLSDSDTFPSENSNRSRSFKESTDNTISISRESLGNPYSSISSPSDYDVKSFTTSRELVSSESILPFSDVMDANDMPTSGSNLHSMVFSISVLGEKFNANIEKHKNTNGHYSSMVFTYQSAGLEESDQRIAVTNTKFDQNKIDTTIDSNTFVTSLPFATTLNDQIDQAVPIKIPASSTAGFVSDVLKPDYSKSVQAESVQTDSTTYSEMMSSKRNKNSGFGTSSLNLKPTITVVTKSIDTKVNTMKEGGVSKQVSTTVTEQYDTSTYTPASLLVSDNSGSVSKYSLWMMAFYMLFGLF
InterPro domains: - IPR008966: Adhesion domain superfamily (homologous_superfamily) [49-174]
- IPR043063: Agglutinin-like protein, N-terminal, N2 subdomain (homologous_superfamily) [182-326]
- IPR008440: Agglutinin-like protein repeat (repeat) [403-543]
- IPR033504: Agglutinin-like protein (family) [3-523]
- IPR024672: Agglutinin-like protein, N-terminal (domain) [54-299]
- IPR011252: Fibrogen-binding domain 1 (homologous_superfamily) [18-176]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0050840 (extracellular matrix binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0001968 (fibronectin binding), GO:0043236 (laminin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0031589 (cell-substrate adhesion), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:0042710 (biofilm formation), GO:0043708 (cell adhesion involved in biofilm formation), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall), GO:0030445 (yeast-form cell wall)