Protein: Ubiquitin-ribosomal protein eL40 fusion protein (P62984)
Organism: Mus musculus (Mouse)
Function: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell- cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling
Subcellular location: [Ubiquitin]: Cytoplasm. Nucleus
Sequence: MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK
InterPro domains: - IPR050158: Ubiquitin and ubiquitin-like (family) [1-87]
- IPR019954: Ubiquitin conserved site (conserved_site) [27-52]
- IPR019956: Ubiquitin domain (domain) [11-74]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-96]
- IPR000626: Ubiquitin-like domain (domain) [1-76]
- IPR001975: Large ribosomal subunit protein eL40 domain (domain) [77-128]
- IPR038587: Large ribosomal subunit protein eL40 superfamily (homologous_superfamily) [79-128]
Interaction partners: - Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Ubiquitin-ribosomal protein eL40 fusion protein
- Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin-B
- Polyubiquitin-C
- Small ribosomal subunit protein eS25
- Small ribosomal subunit protein eS6
- Small ribosomal subunit protein eS24
- Small ribosomal subunit protein eS19
- Small ribosomal subunit protein eS1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030054 (cell junction), GO:0005654 (nucleoplasm), GO:0043209 (myelin sheath), GO:0044391 (ribosomal subunit), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0022626 (cytosolic ribosome), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0015934 (large ribosomal subunit), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0031981 (nuclear lumen), GO:0005634 (nucleus), GO:0005840 (ribosome)