Protein: T-cell surface glycoprotein CD5 (CD antigen CD5) (P51882)
Organism: Rattus norvegicus (Rat)
Function: May act as a receptor in regulating T-cell proliferation.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P13379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P13379}.
Sequence: MDSHEVLLAATYLLGTLAAFCLGQSGRGFVGAQVMLSGSNSKCQGLVEVQMNGMKTVCSSSWRLSQDLWKNANEASTVCQQLGCGNPLALGHLTLWNRPKNQILCQGPPWSFSNCSTSSLGQCLPLSLVCLEPQKTTPLPTTTLPTTMPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSRGGTILYKAKARPVDLGNLICKSLQCGSFLTHLSRIETAGTPAPAELRDPRPLPIRWEAQNGSCTSLQQCFQKTTVQEGSQALAVVCSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWAALCDSSAARGPGRWEELCQEQQCGNLISFHVMDADRTSPGVLCTQEKLSQCYQLQKKTHCKRVFITCKDPNPVGLAPGTVASIILTLVLLVVLMVMCGPLIYKKLVKKFRQKKQRQWIGPTGVNQSMSFHRSHTATVRSQVENPAASHVDNEYSQPPRNSRLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL
InterPro domains: - IPR001190: SRCR domain (domain) [34-364]
- IPR003566: T-cell surface glycoprotein CD5 (family) [1-491]
- IPR036772: SRCR-like domain superfamily (homologous_superfamily) [30-369]
Interaction partners: - CD19 molecule
- T-cell surface glycoprotein CD4
- T-cell surface antigen CD2
- Complement C3d receptor 2.
- Cd72 molecule
- C-C motif chemokine receptor 7
- Antigen-presenting glycoprotein CD1d
- T-cell surface glycoprotein CD3 epsilon chain
- Leukosialin
- Proto-oncogene tyrosine-protein kinase LCK
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048584 (positive regulation of response to stimulus), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0002253 (activation of immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0032101 (regulation of response to external stimulus), GO:0031349 (positive regulation of defense response), GO:0002218 (activation of innate immune response), GO:0031347 (regulation of defense response), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0045089 (positive regulation of innate immune response), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0002221 (pattern recognition receptor signaling pathway), GO:0002752 (cell surface pattern recognition receptor signaling pathway), GO:0002224 (toll-like receptor signaling pathway), GO:0140895 (cell surface toll-like receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)