Protein: Leucine-rich repeat LGI family member 4 (LGI1-like protein 3) (Leucine-rich glioma-inactivated protein 4) (Q8N135)
Organism: Homo sapiens (Human)
Function: Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).
Subcellular location: Secreted {ECO:0000305}.
Sequence: MGGAGILLLLLAGAGVVVAWRPPKGKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLLLASASQRPVLFHWTGGRFERRTDIPEAEDVYATRHFQAGGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLSA
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [25-211]
- IPR005492: Leucine-rich glioma-inactivated , EPTP repeat (repeat) [213-438]
- IPR009039: EAR (repeat) [210-532]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [75-146]
- IPR001611: Leucine-rich repeat (repeat) [100-159]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [158-207]
- IPR051295: Leucine-rich glioma-inactivated/LGI-related (family) [7-537]
Interaction partners: - Disintegrin and metalloproteinase domain-containing protein 22
- Disintegrin and metalloproteinase domain-containing protein 23
- Disintegrin and metalloproteinase domain-containing protein 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0008283 (cell population proliferation), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0051239 (regulation of multicellular organismal process), GO:0007272 (ensheathment of neurons), GO:0007610 (behavior), GO:2000026 (regulation of multicellular organismal development), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0031641 (regulation of myelination), GO:0048731 (system development), GO:0014009 (glial cell proliferation), GO:0071695 (anatomical structure maturation), GO:0007626 (locomotory behavior), GO:0022008 (neurogenesis), GO:0042551 (neuron maturation), GO:0007399 (nervous system development), GO:0008344 (adult locomotory behavior), GO:0042552 (myelination), GO:0007422 (peripheral nervous system development), GO:0032292 (peripheral nervous system axon ensheathment), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0051960 (regulation of nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042063 (gliogenesis), GO:0048699 (generation of neurons), GO:0014037 (Schwann cell differentiation), GO:0022011 (myelination in peripheral nervous system), GO:0014044 (Schwann cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)