Protein: Splicing factor Cactin (B6KG46)
Organism: Toxoplasma gondii (strain ATCC 50861 / VEG)
Function: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (By similarity). Involved in the regulation of G1 progression and stage differentiation of tachyzoites. May play a role in gene expression.
Subcellular location: Nucleus {ECO:0000269|PubMed:22486860}. Note=Localizes in the nucleus throughout the entire tachyzoite cell cycle. {ECO:0000269|PubMed:22486860}.
Sequence: MGKKRRKHDGSGSSRSPSPDRIREARNPSQAEVAGFRAPPSGKPAMTVKQLREERQKLLHEHFGYSNTNNPFGDRLLAEPFVWKKKNQLLQAAGQKGKTTVAALIHSSKSKVQEIENVKRRREEREKEEELMQQQREELQREKEREHYEEYAQKEELFHRSNQLKKTEIRLEQNRAQLIDLIVKGLRIIKGERFEKMDVLPGPPHEVLETYKNEPVTVAMLEDLIADVKLHIDVDTTVVDADFQDFWKSLLVLAREALERAKKRKDVLDQLARNSSPQMAAEAAAQLADTVCPQIRDADTGIVLSVAHEIEGLLGGKSAAELDELEAQIRSKFEEEDIDVAYWEGILNKIPSFRARAVCLQTWHMMTQSAADAEREMAREKALKEEEEAKAARAKGEELEGLLLEEADARKLARAQQIKQDAIKVARSVEKDVNPNADGSFSPELEPYDEGEVPPPVRGPYSPQLWPFDEFRHAEILAPDDDEDRRAILKKTLIQKERLKRAGLEEDPEPTPEAAENDASLDVLDPAAKVTTYEEFVKKEKKNLEADEEVMASSSEHKLTMHYTWEEKYRPRKPRFFNRVKTGYSWNKYNTTHYDHDNPPPKVVQGYKFNIFYPDLIDKTKAPTWFLEPSDTPDTVIIRFHAGPPYEDIAFKILNQEWQLERFRGFRNVFDRGIMQLYFSFKRYIYRR
InterPro domains: - IPR019134: Splicing factor Cactin, C-terminal (domain) [565-688]
- IPR018816: Splicing factor cactin, central domain (domain) [141-358]
Interaction partners: - Cwf18 pre-mRNA splicing factor protein
- Pre-mRNA-processing factor 17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0120114 (Sm-like protein family complex), GO:0030532 (small nuclear ribonucleoprotein complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0097525 (spliceosomal snRNP complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)