Protein: LHFPL tetraspan subfamily member 4 protein (Lipoma HMGIC fusion partner-like 4 protein) (Q7TSY2)
Organism: Rattus norvegicus (Rat)
Function: Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in concert with NLGN2 to recruit or stabilize GABAARs.
Subcellular location: Cell projection, dendrite {ECO:0000269|PubMed:28978485}. Postsynaptic cell membrane {ECO:0000269|PubMed:28978485, ECO:0000269|PubMed:29742426}; Multi-pass membrane protein {ECO:0000255}. Note=Specifically localizes to inhibitory postsynaptic sites (PubMed:29742426). Colocalizes with GPHN, GABRG2 and NLGN2 at inhibitory postsynaptic sites (PubMed:28978485, PubMed:29742426). {ECO:0000269|PubMed:28978485, ECO:0000269|PubMed:29742426}.
Sequence: MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKQENKDFVGTTVSSVLRPGGDVSGWGVLPCPVAHTQGP
InterPro domains: - IPR019372: Lipoma HMGIC fusion partner-like protein (family) [1-215]
Interaction partners: - Neuroligin-2
- Gephyrin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0050811 (GABA receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0099072 (regulation of postsynaptic membrane neurotransmitter receptor levels), GO:0051668 (localization within membrane), GO:0051128 (regulation of cellular component organization), GO:0097120 (receptor localization to synapse), GO:0044087 (regulation of cellular component biogenesis), GO:0099645 (neurotransmitter receptor localization to postsynaptic specialization membrane), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:0008104 (protein localization), GO:0099173 (postsynapse organization), GO:0034330 (cell junction organization), GO:0061024 (membrane organization), GO:0072657 (protein localization to membrane), GO:0051963 (regulation of synapse assembly), GO:0033365 (protein localization to organelle), GO:1902414 (protein localization to cell junction), GO:0001941 (postsynaptic membrane organization), GO:0050808 (synapse organization), GO:1903539 (protein localization to postsynaptic membrane), GO:1990778 (protein localization to cell periphery), GO:0043113 (receptor clustering), GO:0099633 (protein localization to postsynaptic specialization membrane), GO:0035418 (protein localization to synapse), GO:0072578 (neurotransmitter-gated ion channel clustering), GO:0062237 (protein localization to postsynapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0098982 (GABA-ergic synapse), GO:0098978 (glutamatergic synapse)