Protein: Muscarinic acetylcholine receptor M5 (P08912)
Organism: Homo sapiens (Human)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Subcellular location: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein.
Sequence: MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
InterPro domains: - IPR000995: Muscarinic acetylcholine receptor family (family) [32-512]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [47-495]
- IPR000502: Muscarinic acetylcholine receptor M5 (family) [11-531]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [32-503]
Interaction partners: - Metabotropic glutamate receptor 5
- Muscarinic acetylcholine receptor M3
- Guanine nucleotide-binding protein G
- Muscarinic acetylcholine receptor M1
- Guanine nucleotide-binding protein G
- Kininogen-1
- Guanine nucleotide-binding protein subunit alpha-11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0005515 (protein binding), GO:0016787 (hydrolase activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0015464 (acetylcholine receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0099528 (G protein-coupled neurotransmitter receptor activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0004930 (G protein-coupled receptor activity), GO:0016907 (G protein-coupled acetylcholine receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004620 (phospholipase activity), GO:0004629 (phospholipase C activity), GO:0004435 (phosphatidylinositol phospholipase C activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0045913 (positive regulation of carbohydrate metabolic process), GO:0035556 (intracellular signal transduction), GO:0098660 (inorganic ion transmembrane transport), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0071417 (cellular response to organonitrogen compound), GO:0098655 (monoatomic cation transmembrane transport), GO:0043255 (regulation of carbohydrate biosynthetic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0071310 (cellular response to organic substance), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0032881 (regulation of polysaccharide metabolic process), GO:1901699 (cellular response to nitrogen compound), GO:0010676 (positive regulation of cellular carbohydrate metabolic process), GO:0071702 (organic substance transport), GO:0006109 (regulation of carbohydrate metabolic process), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0006811 (monoatomic ion transport), GO:0019932 (second-messenger-mediated signaling), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0031326 (regulation of cellular biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1902932 (positive regulation of alcohol biosynthetic process), GO:0006812 (monoatomic cation transport), GO:0045937 (positive regulation of phosphate metabolic process), GO:0019722 (calcium-mediated signaling), GO:0019220 (regulation of phosphate metabolic process), GO:0006816 (calcium ion transport), GO:0010919 (regulation of inositol phosphate biosynthetic process), GO:0070509 (calcium ion import), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006828 (manganese ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)