wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: ATMRK1 (Protein kinase superfamily protein) (O22100)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MASGGGEADKSLEIGSGTADPKIGGTGSRSAGEERYFRADTLDFSKWDLHMGQTSTSSVLTNSASTSAPAPAMQEWEIDLSKLDMKHVLAHGTYGTVYRGVYAGQEVAVKVLDWGEDGYATPAETTALRASFEQEVAVWQKLDHPNVTKFIGASMGTSDLRIPPAGDTGGRGNGAHPARACCVVVEYVAGGTLKKFLIKKYRAKLPIKDVIQLALDLARGLSYLHSKAIVHRDVKSENMLLQPNKTLKIADFGVARVEAQNPQDMTGETGTLGYMAPEVLEGKPYNRKCDVYSFGVCLWEIYCCDMPYADCSFAEISHAVVHRNLRPEIPKCCPHAVANIMKRCWDPNPDRRPEMEEVVKLLEAIDTSKGGGMIAPDQFQGCLCFFKPRGP
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [55-362]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [229-241]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [84-361]
- IPR000719: Protein kinase domain (domain) [83-365]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [63-366]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0019538 (protein metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0097305 (response to alcohol), GO:0032870 (cellular response to hormone stimulus), GO:0043412 (macromolecule modification), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0006796 (phosphate-containing compound metabolic process), GO:0009737 (response to abscisic acid), GO:1901701 (cellular response to oxygen-containing compound), GO:0009738 (abscisic acid-activated signaling pathway), GO:0016310 (phosphorylation), GO:0071215 (cellular response to abscisic acid stimulus), GO:0097306 (cellular response to alcohol), GO:0006468 (protein phosphorylation), GO:0071396 (cellular response to lipid), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: Baculoviral IAP repeat-containing 3 (Q5XIW4)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MNMVQGSAFLAKLMKSADTFELKYDFSCELYRLSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFSCGLMLDNWKQGDSPIEKHRKLYPSCSFVQTLNPANSLEASPQPPLPSTATSTMPSGFAASESTGYFSGSYSSFPSDPVNFRANQDCPAFSTSPYHFAMNTEKARLLTYQTWPLSFLSPAELAKAGFYYTGPGDRVACFACGGKLSNWDRKDDPLSEHRRHFPSCPFLKDVGQFTSQYTVSNLSMQTHAARVRTFSTWPSSALVHPQELASAGFYYTGHSDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEYLIRIKGQEFVGQVQAGYPHLLEQLLSTSDSPEDETGEAAIVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDLVIGLLDAEDEMREEQTEQEAEEEESDDLTLIRKNKMVLLQHLTPVTPILDCLLSARVITEQEYDAVKQKPHTLQARTLIDTVLAKGNTAATSFRNSLQEIDPGLYRDIFVRQNIRSLPTDDIAALPMEEQLRKLQEERTCKVCMDREVSLVFIPCGHLVVCKECAPSLRKCPICRGTIKGTVRTFLS
InterPro domains: - IPR041933: BIRC2/BIRC3, UBA domain (domain) [376-425]
- IPR001370: BIR repeat (repeat) [27-324]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [437-563]
- IPR001315: CARD domain (domain) [438-527]
- IPR048875: BIRC2/3-like, UBA domain (domain) [373-425]
- IPR050784: Inhibitor of Apoptosis (family) [27-602]
- IPR001841: Zinc finger, RING-type (domain) [555-590]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)
Protein: Progonadoliberin-1 (Progonadoliberin I) [Cleaved into: Gonadoliberin-1 (Gonadoliberin I) (Gonadotropin-releasing hormone I) (GnRH-I) (Luliberin I) (Luteinizing hormone-releasing hormone I) (LH-RH I); GnRH-associated peptide 1 (GnRH-associated peptide I)] (Q28588)
Organism: Ovis aries (Sheep)
Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location: Secreted.
Sequence: QHWSYGLRPGGKRNAKNVIDSFQEIAKEVDQPVEPKCCGCIVHQSHSPLRDLKAALESLIE
InterPro domains: - IPR019792: Gonadoliberin (family) [1-61]
- IPR002012: Gonadotropin-releasing hormone (conserved_site) [1-10]
- IPR004079: Gonadoliberin I precursor (family) [1-61]
Interaction partners: - Gonadotropin-releasing hormone receptor
- KiSS-1 receptor
- non-specific serine/threonine protein kinase
- Placental prolactin-related protein 4
- Placental prolactin-related protein 3-like
- Uncharacterized protein
- Metastasis-suppressor KiSS-1
- Mitogen-activated protein kinase
- mitogen-activated protein kinase
- Pro-FMRFamide-related neuropeptide VF
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0043279 (response to alkaloid), GO:0071867 (response to monoamine)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Auxin canalization protein (DUF828) (Q8VY20)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MEKLMVPTWRPDPVYRPPETPLEPMEFLARSWSVSALEVSKALTPPNPQILLSKTEEEEEEEPISSVVDGDGDTEDTGLVTGNPFSFACSETSQMVMDRILSHSQEVSPRTSGRLSHSSGPLNGSLTDSPPVSPPESDDIKQFCRANKNSLNSVNSQFRSTAATPGPITATATQSKTVGRWLKDRREKKKEETRAHNAQIHAAVSVAGVAAAVAAIAAATAASSSCGKDEQMAKTDMAVASAATLVAAQCVEAAEVMGAEREYLASVVSSAVNVRSAGDIMTLTAGAATALRGVQTLKARAMKEVWNIASVIPMDKGLTSTGGSSNNVNGSNGSSSSSHSGELVQQENFLGTCSREWLARGCELLKRTRKGDLHWKIVSVYINKMNQVMLKMKSRHVGGTFTKKKKNIVLDVIKNVPAWPGRHLLEGGDDLRYFGLKTVMRGDVEFEVKSQREYEMWTQGVSRLLVLAAERKFRM
InterPro domains: - IPR040269: VAN3-binding protein (family) [15-469]
- IPR013666: Pleckstrin-like, plant (domain) [363-467]
- IPR008546: VAN3-binding protein-like, auxin canalisation domain (domain) [18-317]
Interaction partners: - ADP-ribosylation factor GTPase-activating protein AGD7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009888 (tissue development), GO:0009755 (hormone-mediated signaling pathway), GO:0003002 (regionalization), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0032870 (cellular response to hormone stimulus), GO:0010087 (phloem or xylem histogenesis), GO:0010051 (xylem and phloem pattern formation), GO:0071310 (cellular response to organic substance), GO:0009734 (auxin-activated signaling pathway), GO:0009733 (response to auxin), GO:0016192 (vesicle-mediated transport), GO:0048193 (Golgi vesicle transport), GO:0010305 (leaf vascular tissue pattern formation), GO:0071365 (cellular response to auxin stimulus), GO:0006892 (post-Golgi vesicle-mediated transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005802 (trans-Golgi network)
Protein: Terpenoid synthase 22 (AtTPS22) (EC 4.2.3.-) (Q9LQ27)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in terpene biosynthesis in roots. Possesses sesquiterpene (C15) synthase activity in vitro. Does not seem to be involved in diterpene (C20) biosynthesis.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MEAARMGFRAKTLPHLGNGTRLPLKTKLSLFPMHLLQNHTTLSRRSTKLNLCVKACSKTSGVESSRPLPHSAPDLWGDHILSVPTENSEFDTLETEIESIKPKVRNMLMSSHKTDKERICLIHLLICLGTFHYFEKEIEEILEQAFRKLDMLFTDEDDLETTAIMFEVFRLYGHKISCDVFDRFKGVDAKFKEHLVSDVRGMLQLYEAAHLATPFETILDEALSFTRYHLESLAGQQATAPHISRHILNALYKPRFLKMEIIAAREYIHFYQKEGHDETLLKFAKLNFNFCQLHYVRELKTLTKWWKDIDLPYKLPYIRDRLLETFIGVMAVYLEPHYSLGRIIATKVSQVIVVMDDTCDAYGTFSEVRSLIDSLERWDPGAIDKLPSCLRIVIQSIVETMEDIEREMKPRGRSSSVQDTVEEIKIMGRAYAEISKWARAGHVPTFDDYIELGLDSSGIRCFAMYSFISMEDCEENQTNAWFKSKPKMLRALSVIFRLTNDIAGFEEEMRRGEVVNGVNCYVKQHNVTKELAVREIKKMIRDNYKIMMEEFLTIKSVSRPILVRCFNIVRLVNLYYEEGDNFTNPNGKLKDLITSLFFHPLPL
InterPro domains: - IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [75-275]
- IPR005630: Terpene synthase, metal-binding domain (domain) [307-545]
- IPR001906: Terpene synthase, N-terminal domain (domain) [75-251]
- IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [73-601]
- IPR034741: Terpene cyclase-like 1, C-terminal domain (domain) [277-601]
- IPR050148: Terpene synthase-like (family) [66-600]
- IPR044814: Terpene cyclases, class 1, plant (family) [66-600]
- IPR036965: Terpene synthase, N-terminal domain superfamily (homologous_superfamily) [113-276]
Interaction partners: - Uncharacterized protein At4g13230
- Probable alpha,alpha-trehalose-phosphate synthase 7
- Putative inactive
- Geranylgeranyl pyrophosphate synthase 3, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0016838 (carbon-oxygen lyase activity, acting on phosphates), GO:0010333 (terpene synthase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006721 (terpenoid metabolic process), GO:0016114 (terpenoid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Uncharacterized protein C16E9.19 (Q9C0X2)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MFPKIKQTSKNYNGKEIQAISMRFSNQITILVTISGKIGQMYMMTYEKSVMSPVSITGDMSTLPEIGVRTLLGGGGEDDIKSHWAQITAGQVGSLLARQQMLVRPDVRIPRVCLGLHVPWTDDNEKNGDLTVVILELVKEICF
InterPro domains: - IPR053720: Proteasome Assembly Chaperone (homologous_superfamily) [1-140]
- IPR018788: Proteasome assembly chaperone 3 (family) [4-138]
Interaction partners: - UDP-N-acetylglucosamine transferase subunit alg14
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0065003 (protein-containing complex assembly), GO:0042254 (ribosome biogenesis), GO:0022618 (ribonucleoprotein complex assembly), GO:0042273 (ribosomal large subunit biogenesis), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0042255 (ribosome assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000027 (ribosomal large subunit assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Tubulin-tyrsoine ligase-like protein, putative (EC 6.3.2.-) (Q384Y9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MRNMMEPVIARPRKQVATAVLISETLSSTLHVREESMGGAAGTGHISEDGGSKVGVLRADAPLSVNPSRRRCSGSMARPRLDAGTLGSPFAKSTKKTIRELIDMSGTSVKEEVVEKQDKTVIIQHSTIRKPVGIDMRGGSISTPKKINVSPKPISPIRRGWHSAGSAGKVGERTPCETTRERDSSASRSPVHRRSAGSAMSRLESNVSTPNSSKNSTVSRGAIGAFGPFSPLSSLRLTDLERPGTRSTPLNSLTKTPGSRRARPQYKIVNLALCKYPLLRIIAQENGFKIQELEDDLERNNFNIVWSDTVLPLTRLVRLANWQRTNHFPSMYLLCRKGHLGITLGRMRKVMPSHYIFYPRTWSLRSERHQFARFLMALRSKKLSKFFIMKPNSGCQGRGIMITRDPLNAVEDLDNYIVQEYITRPLLLEGRKFDLRVYVLLTSIRAPSIFLFNDGLVRQCAELYERPTDANVKNTCKHLTNYAVNKHNPEYVFNDDPANCNVGNKRNFKFFNEWLESCGKSVEQFWARVAHVICKTILVAQPQIANVYNSCFPRHNSGYSCFEVLGFDILVDNKMKPWLMEVNHTPSLVTDTPLDYEVKHALISEVWDILDVKVTDRKRDERKERDEFIQRMMRPPVNTANTHTTTAQKRQNSGDTANGVATNGSSSNANQASNATGAGSSSTQDGMTEWEKTVEGRRAAEDSRLRNFRRIYPSDNSDWQALYDMILAQARALCSGPLVPGADDRLRRVDTTSVAGSLQPSQSGGSTAERSGRGGAPEAIGEGSVQSAAGVLRLGQRQRPQEASPSYRKTRRVTGTTTPTPTPGAQVQKTPLELNQGTTVPQAPLLRPPQLPPSMELANVVVHQKERRPTLMNRVCLPDSTLAEKVVTVTTGRESDGHGRGATADLGVGLRKTHVVSARILSPVGKASPGLITTSPPESPTADRIEALRSLQKRLDQEAECEISTTQENAEREDSFHLDE
InterPro domains: - IPR004344: Tubulin-tyrosine ligase/Tubulin polyglutamylase (family) [264-622]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0070739 (protein-glutamic acid ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016881 (acid-amino acid ligase activity), GO:0070740 (tubulin-glutamic acid ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0018193 (peptidyl-amino acid modification), GO:0018200 (peptidyl-glutamic acid modification), GO:0018095 (protein polyglutamylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0036064 (ciliary basal body), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Debris buster, isoform D (IP12256p) (A8JNI3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
Sequence: MGLEKHYLRYGRTARDHLLDWATCGRGRRQQQQQQQQQTHAQPSQGSTATGRRSRPHVTHRGTPLSMLISNGVRISNNRLAVIIIGIITLILGIILSSMPWLDYFILKNLRLWNDTLSYHYWQRPGVIRLTKLYIYNVTNPDGFLRGEKPHLQEVGPFVYREDMQKVNVKFHENNYTVSYQHKKILQFVPELSIDKDTPITTPNIPLLTLTSLSPKLGYLLSKTISVVVTAAQFKPFINVTAEQLAFGYDDALVSLAHRFYPKHMRPMERMGLLLGRNGTLTEVSSVKTGMDSMDQFGYIDQLNGLDHLPHWSEPPCTSIAGSEGSFFPPRELTKSEVVHIYDKDLCRIIPLKYVESLEKDGIAADLFRLPNNSYGDSAHNPENKCYDTSEYEPIQGLQNISPCQYGAPVYISNPHFFESHPDLLNSVEGLKPEREKHETYFKIQPKLGVPLEGKVRIQLNLKVTRAKDVYPVRDFRDFVFPVMWLEEGISELTPAIKRWIYLGTVIAPSAVPIGSYLMILGGAFAIIFSFVRAYQNFMFAQDPTLEILEMGRRSLRRGSSFIAHQQHRLLVHHRDSYSLLRHGPMATCLGEGNREEDAQPIIDVSLSGGISQES
InterPro domains: - IPR002159: CD36 family (family) [81-538]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0038024 (cargo receptor activity), GO:0005044 (scavenger receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0090382 (phagosome maturation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle)
Protein: Citrate/malate-proton symporter (CimHbs) (Citrate/malate transporter) (P94363)
Organism: Bacillus subtilis (strain 168)
Function: Proton motive force-driven secondary transporter that catalyzes the uptake of both citrate and malate. Appears to be an electroneutral proton-solute symporter; the number of protons transported is equal to the valence of the transported anions. Is strictly stereoselective, translocating only the (S)-enantiomer of malate.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11566984}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALLFILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAVVYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVGSVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAFALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFNLSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVSRFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMYPIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY
InterPro domains: - IPR004679: 2-hydroxycarboxylate transporter (family) [11-450]
- IPR018025: 2-hydroxycarboxylate transporter, proteobacteria/firmicutes (family) [27-444]
Interaction partners: - Sensor protein CitS
- Malate-2H
- Transcriptional regulatory protein CitT
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0005310 (dicarboxylic acid transmembrane transporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015295 (solute:proton symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015849 (organic acid transport), GO:0006865 (amino acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)