Protein: Serpin B4 (P48594)
Organism: Homo sapiens (Human)
Function: May act as a protease inhibitor to modulate the host immune response against tumor cells
Subcellular location: Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level
Sequence: MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP
InterPro domains: - IPR036186: Serpin superfamily (homologous_superfamily) [1-390]
- IPR042178: Serpin superfamily, domain 1 (homologous_superfamily) [13-336]
- IPR042185: Serpin superfamily, domain 2 (homologous_superfamily) [188-383]
- IPR023796: Serpin domain (domain) [6-390]
- IPR023795: Serpin, conserved site (conserved_site) [363-373]
- IPR000215: Serpin family (family) [4-390]
Interaction partners: - Serpin B3
- Cathepsin G
- Chymotrypsin-like protease CTRL-1
- Protein S100-A7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0019899 (enzyme binding), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0002020 (protease binding), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009892 (negative regulation of metabolic process), GO:0031341 (regulation of cell killing), GO:0050777 (negative regulation of immune response), GO:0050790 (regulation of catalytic activity), GO:0002831 (regulation of response to biotic stimulus), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0031348 (negative regulation of defense response), GO:0050776 (regulation of immune response), GO:0032102 (negative regulation of response to external stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0002697 (regulation of immune effector process), GO:0080134 (regulation of response to stress), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002698 (negative regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0031342 (negative regulation of cell killing), GO:0031347 (regulation of defense response), GO:0043086 (negative regulation of catalytic activity), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0051246 (regulation of protein metabolic process), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0001911 (negative regulation of leukocyte mediated cytotoxicity), GO:0051336 (regulation of hydrolase activity), GO:0002704 (negative regulation of leukocyte mediated immunity), GO:0051248 (negative regulation of protein metabolic process), GO:0045824 (negative regulation of innate immune response), GO:0002716 (negative regulation of natural killer cell mediated immunity), GO:0051346 (negative regulation of hydrolase activity), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0030162 (regulation of proteolysis), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0052547 (regulation of peptidase activity), GO:0045861 (negative regulation of proteolysis), GO:0045953 (negative regulation of natural killer cell mediated cytotoxicity), GO:0002715 (regulation of natural killer cell mediated immunity), GO:0002707 (negative regulation of lymphocyte mediated immunity), GO:0010466 (negative regulation of peptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0005766 (primary lysosome)