Protein: Ankyrin 2 (A0A5F9ZHD2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPPDETQSTQKQHKPSLGIKKPVRRKLKEKQKQKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVSRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLPKDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVIEIPTAPMENVPFTESKSKIPVRTMPTSTPAPPSAEYESSVSEDFLSSVDEENKADEAKPKSKLPVKVPLQRVEQQLSDLDTSVQKTVAPQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRERAEELELESEEGATRPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPPVETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDEDAAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDNNE
InterPro domains: - IPR011029: Death-like domain superfamily (homologous_superfamily) [3534-3653]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [2-824]
- IPR051165: Multifunctional Ankyrin Repeat Domain-Containing Protein (family) [555-1448]
- IPR002110: Ankyrin repeat (repeat) [9-792]
- IPR040745: Ankyrin, UPA domain (domain) [1303-1432]
- IPR000488: Death domain (domain) [3538-3632]
- IPR000906: ZU5 domain (domain) [945-1283]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0044325 (transmembrane transporter binding), GO:0030507 (spectrin binding), GO:0019899 (enzyme binding), GO:0140030 (modification-dependent protein binding), GO:0008092 (cytoskeletal protein binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0032502 (developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0060306 (regulation of membrane repolarization), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0030029 (actin filament-based process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0086065 (cell communication involved in cardiac conduction), GO:0030048 (actin filament-based movement), GO:0051049 (regulation of transport), GO:0086019 (cell-cell signaling involved in cardiac conduction), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0051282 (regulation of sequestering of calcium ion), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0003279 (cardiac septum development), GO:0034762 (regulation of transmembrane transport), GO:0060255 (regulation of macromolecule metabolic process), GO:0031647 (regulation of protein stability), GO:0051668 (localization within membrane), GO:0003205 (cardiac chamber development), GO:0032970 (regulation of actin filament-based process), GO:0003013 (circulatory system process), GO:0003012 (muscle system process), GO:0002027 (regulation of heart rate), GO:0010646 (regulation of cell communication), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0099623 (regulation of cardiac muscle cell membrane repolarization), GO:0070727 (cellular macromolecule localization), GO:0098901 (regulation of cardiac muscle cell action potential), GO:0008015 (blood circulation), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0003283 (atrial septum development), GO:0006936 (muscle contraction), GO:0086091 (regulation of heart rate by cardiac conduction), GO:0071702 (organic substance transport), GO:0010628 (positive regulation of gene expression), GO:0090257 (regulation of muscle system process), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0010468 (regulation of gene expression), GO:0001508 (action potential), GO:1903115 (regulation of actin filament-based movement), GO:0019932 (second-messenger-mediated signaling), GO:0051899 (membrane depolarization), GO:0072359 (circulatory system development), GO:0003015 (heart process), GO:0070252 (actin-mediated cell contraction), GO:0008104 (protein localization), GO:0003230 (cardiac atrium development), GO:0043269 (regulation of monoatomic ion transport), GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0007507 (heart development), GO:0072657 (protein localization to membrane), GO:0006937 (regulation of muscle contraction), GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum), GO:0033365 (protein localization to organelle), GO:0006812 (monoatomic cation transport), GO:0060047 (heart contraction), GO:1990778 (protein localization to cell periphery), GO:0010959 (regulation of metal ion transport), GO:0019722 (calcium-mediated signaling), GO:0086004 (regulation of cardiac muscle cell contraction), GO:0006941 (striated muscle contraction), GO:0008016 (regulation of heart contraction), GO:0086001 (cardiac muscle cell action potential), GO:0072659 (protein localization to plasma membrane), GO:0086003 (cardiac muscle cell contraction), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0006816 (calcium ion transport), GO:0086010 (membrane depolarization during action potential), GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion), GO:0055117 (regulation of cardiac muscle contraction), GO:0061337 (cardiac conduction), GO:0070296 (sarcoplasmic reticulum calcium ion transport), GO:0006942 (regulation of striated muscle contraction), GO:0060048 (cardiac muscle contraction), GO:0030001 (metal ion transport), GO:0070972 (protein localization to endoplasmic reticulum), GO:0051924 (regulation of calcium ion transport), GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0086002 (cardiac muscle cell action potential involved in contraction), GO:1903779 (regulation of cardiac conduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)