Protein: Prosaposin (Sulfated glycoprotein 1) (SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D] (Q61207)
Organism: Mus musculus (Mouse)
Function: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
Subcellular location: [Prosaposin]: Secreted {ECO:0000269|PubMed:23690594}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000269|PubMed:23690594}.; SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P07602}.
Sequence: MYALALFASLLATALTSPVQDPKTCSGGSAVLCRDVKTAVDCGAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATQEEILHYLEKTCEWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQKQLESNKIPEVDMARVVAPFMSNIPLLLYPQDHPRSQPQPKANEDVCQDCMKLVSDVQTAVKTNSSFIQGFVDHVKEDCDRLGPGVSDICKNYVDQYSEVCVQMLMHMQDQQPKEICVLAGFCNEVKRVPMKTLVPATETIKNILPALEMMDPYEQNLVQAHNVILCQTCQFVMNKFSELIVNNATEELLVKGLSNACALLPDPARTKCQEVVGTFGPSLLDIFIHEVNPSSLCGVIGLCAARPELVEALEQPAPAIVSALLKEPTPPKQPAQPKQSALPAHVPPQKNGGFCEVCKKLVLYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDDFVAEYEPLLLEILVEVMDPGFVCSKIGVCPSAYKLLLGTEKCVWGPSYWCQNMETAARCNAVDHCKRHVWN
InterPro domains: - IPR008139: Saposin B type domain (domain) [59-519]
- IPR011001: Saposin-like (homologous_superfamily) [60-517]
- IPR021165: Saposin, chordata (family) [1-557]
- IPR008373: Saposin (family) [18-543]
- IPR008138: Saposin B type, region 2 (domain) [106-515]
- IPR007856: Saposin-like type B, region 1 (domain) [62-477]
- IPR003119: Saposin A-type domain (domain) [18-557]
- IPR051428: Sphingolipid Activators and Surfactant Proteins (family) [310-518]
Interaction partners: - Prosaposin receptor GPR37
- Lysosomal acid glucosylceramidase
- G-protein coupled receptor 37-like 1
- Galactocerebrosidase
- Progranulin
- Proactivator polypeptide-like 1
- Lysosome-associated membrane glycoprotein 1
- Cathepsin D
- Acid ceramidase
- Sortilin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009894 (regulation of catabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0060341 (regulation of cellular localization), GO:0044255 (cellular lipid metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0043603 (amide metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0006672 (ceramide metabolic process), GO:1903509 (liposaccharide metabolic process), GO:0006665 (sphingolipid metabolic process), GO:0071705 (nitrogen compound transport), GO:0006643 (membrane lipid metabolic process), GO:0006672 (ceramide metabolic process), GO:1903509 (liposaccharide metabolic process), GO:0032880 (regulation of protein localization), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0031329 (regulation of cellular catabolic process), GO:0006664 (glycolipid metabolic process), GO:0006687 (glycosphingolipid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)