Protein: Tubulin-specific chaperone D (Tubulin folding cofactor D homolog) (Q19493)
Organism: Caenorhabditis elegans
Function: Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization.
Sequence: MDEDAPVDESNEGIIGCLPSAVNIHHIEEIKELVDQLPIIFKLENECDETAAEVNYLRYSRLLHLYQEQPRLLDKWIPEIVANLVDLVTLIGIDVSKPRAMTPLSRESLKYLSDLCIVRGSKTIVRLLPHQVHLLDPLLQTLEYYETSQLSDHNQRNVLLMWLWIVVKNPFDLRRFDPTGDPDNVITRIMNVALHYMKWDWNSSQASAALVIAHCLSRTDGIPKVLSFLSRLLDSIKTHHENKKLLLADLILLLAILKHVDRRVLTGHIGTIHEQLSFLYPIDEKKGGLICKCLVKVVQRIGLIALKPRTCSWSYNRGKRLLEGMLDDNEEYSDEPSFSNKVNSNQSCNNEIDKENQWNDGDELENSEIVEFALMHVLEALSHSDTAVRWSAAKGVGRITVRLPNFDLATQVVGSIISSHFGEVAEYSSWHSHGACLALAELAHRGVLLPSLLEDIVPALELSLVFEDVMGRHQNGNQVRDAACYAVWALSRTYEPSMMAPYLQRLASALLCGALFDRQVNLRRAASAALQEMVGRQKNVSHGIPLIQSVDYFAVTNRQKCYEHLCVPVAEYSTYSAIILRHLITKKVVHWDEKIREQAAISLEKISEIRLENVSDDYYMEILDDFLKASCETRISPFLRHGYLLASGHLIKGLTSRGMDFSSKQTEIAWIPHILWPFCDMTTQPGALIRRTLCKFIQLVSASKKVLLLEKDKSEWLDVLLQLITDPREIIRSLAKTAVGEFVMTYLMNDEELIQKVKTRVIAAMTKCSDESERIGMGMICESLNSEAVDYEMFESLCNTILTPTSSDAKWALARQQTVFALNRISVNSSTETFNRIGQKCFETLYKAMTDYTTSANGDIGRFVREASMRAMSTILVDAKTEPPFLDEHVIKSAKYMVQQSAERISRTRECACACLKSLVKCEITGRCLPHIDLLMNIYSEPMDFISDRTVFQLKPLLDLGSEYYEQLILGIVVSAGGLAEGTQKTAKQLLLDHQREICENKPRFDHFLSTCADLFQRARKVNRIGNSFMQILPQIFGNLGIYEQCPETSESIIEMVDTMKTIAVRSSMMSRQRLSIDSLGELLNCGKKSTVYRSALTMILDTLNSQQPVLRKSAAERLYEHLCCAEESDDEVLEVLATTNWQDENDNVLKQAVAGISEKLIF
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [102-1119]
- IPR058033: Tubulin-folding cofactor D, ARM repeats (domain) [290-544]
- IPR011989: Armadillo-like helical (homologous_superfamily) [121-950]
- IPR033162: Tubulin-folding cofactor D (family) [7-1148]
- IPR022577: Tubulin-folding cofactor D, C-terminal domain (domain) [895-1070]
Interaction partners: - ADP-ribosylation factor-like protein 2
- Tubulin-specific chaperone E
- CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
- ATP synthase mitochondrial F1 complex assembly factor 2
- Carbonic anhydrase
- Beta carbonic anhydrase 1
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- Tubulin-specific chaperone B
- C-CAP/cofactor C-like domain-containing protein
- Tubulin-specific chaperone A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007163 (establishment or maintenance of cell polarity), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0008283 (cell population proliferation), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0032989 (cellular component morphogenesis), GO:0008356 (asymmetric cell division), GO:0045165 (cell fate commitment), GO:0061351 (neural precursor cell proliferation), GO:0030010 (establishment of cell polarity), GO:1903047 (mitotic cell cycle process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0055057 (neuroblast division), GO:0000226 (microtubule cytoskeleton organization), GO:0000278 (mitotic cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0007405 (neuroblast proliferation), GO:0022008 (neurogenesis), GO:0055059 (asymmetric neuroblast division), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0006996 (organelle organization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0007010 (cytoskeleton organization), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)