Protein: Nibrin (Q9VT40)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Chromosome, telomere {ECO:0000256|ARBA:ARBA00004574}. Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
Sequence: MFVLTKDDEKFVLFPGKKVYTIGRLATDLIVAQDLSISRNHAQLLIQTEADGDDTLHIEDLGSRYGTFIFPKNSQKPRKVPAKTSTPLPVGTRLRFGANMSIWQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTSNWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQPTNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGATCKDINSGVRKTFLTKSDVIVIQYVPSSQSQATESINSIQDRYILEQNGRRIIQEYEIGMALIHCSITEFCNPTHKFISDSLPTTESVTSSMAFNSSIIVPNTERHSAQSNATPISELVVPESIECEMEQDASKPHSEDQASLRKRSHASTVDSSDEEKKSTLSKRAKSDIATKLTMKSKNAILLDSSLEEDVTPAPAPAPVQRVTRQSKAIAEEKSVHPPVPAASKHITRKTKQVFCVDSSDEENENARKPKETPAPTIPSMAKKKTEAPVATRISPRLNGKSLATNITNQPADKHAVPAKRPVLSVASSDEEDEGDLFQFRKSPQKPAETVVQPRIAGKGNAPARISVVDFLEKSQAQEPAPVPPQLESQSQTQPRKRLRLELLNESDSDDCDNLFNFADSKKKRKTQEAQRNDDSTDGLFNFNSERPSDHDDEDSRLTEPFVPETESKKQSKYIVAPRRDRPKKVDISGWLSCSRLNDNIKSEIDADSVKMETSIKADPDEEQWLAAMKDSIEVRMCNLNIVIRSQEEVDASLEDSVNKHGGRKNFKKFVKTKNPHPQKRIVALKSLRLADGMVTCV
InterPro domains: - IPR043014: Nibrin, second BRCT domain superfamily (homologous_superfamily) [205-312]
- IPR000253: Forkhead-associated (FHA) domain (domain) [19-97]
- IPR032429: Nibrin, second BRCT domain (domain) [207-311]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [6-105]
- IPR040227: Nibrin-related (family) [1-794]
- IPR001357: BRCT domain (domain) [116-174]
- IPR016592: Nibrin (family) [5-818]
- IPR036420: BRCT domain superfamily (homologous_superfamily) [107-204]
Interaction partners: - DNA repair protein RAD50
- Double-strand break repair protein
- Serine/threonine-protein kinase ATM
- Serine/threonine-protein kinase ATR
- Microcephalin, isoform D
- DNA repair protein Rad51 homolog
- Regulator of telomere elongation helicase 1 homolog
- PAX-interacting protein 1
- Importin subunit alpha
- Uncharacterized protein, isoform B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0003697 (single-stranded DNA binding), GO:0098847 (sequence-specific single stranded DNA binding), GO:0042162 (telomeric DNA binding), GO:0043047 (single-stranded telomeric DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0012501 (programmed cell death), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0051726 (regulation of cell cycle), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0097190 (apoptotic signaling pathway), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0090304 (nucleic acid metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0006915 (apoptotic process), GO:0006259 (DNA metabolic process), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0006996 (organelle organization), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0000723 (telomere maintenance), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0044818 (mitotic G2/M transition checkpoint), GO:0051276 (chromosome organization), GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0000077 (DNA damage checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0000725 (recombinational repair), GO:0007095 (mitotic G2 DNA damage checkpoint signaling), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle), GO:0032200 (telomere organization), GO:0006302 (double-strand break repair), GO:0000724 (double-strand break repair via homologous recombination), GO:0045003 (double-strand break repair via synthesis-dependent strand annealing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000781 (chromosome, telomeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)