Protein: Presenilin-1 (Q9W6T7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic granule. Cell membrane. Cell projection, axon. Synapse. Cell projection, neuron projection
Sequence: MADLVQNAANNVLNDGMDTSRHTSSTAAPPSRNEVELNGQPPTAPPPQVVTDSEEDEDEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTQKDGQQLIYTPFREDTETVGQRALHSMLNAIIMISVIVVMTLVLVVLYKYRCYKVIQAWLFFSNLLLLFFFSLIYLGEVFKTYNVAMDYFTLALIIWNFGVVGMICIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAAISVYDLLAVLCPKGPLRILVETAQERNEAIFPALIYSSTMVWLFNMADSAETRNNSSHPVPQQENQVVAMAPTAQAEDDGGFTPAWVDHQQHQLGPMQSTEESRRQIQEMPSARPPPPADDDEERGVKLGLGDFIFYSMLVGKASATASGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDNLVRPFMDQLAVHQFYI
InterPro domains: - IPR006639: Presenilin/signal peptide peptidase (family) [119-442]
- IPR001108: Peptidase A22A, presenilin (family) [44-456]
- IPR042524: Presenilin, C-terminal (homologous_superfamily) [341-448]
Interaction partners: - Gamma-secretase subunit PEN-2
- Gamma-secretase subunit Aph-1b
- Catenin beta-1
- Neurogenic locus notch homolog protein 1
- Presenilin-2
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase catalytic subunit alpha
- Apolipoprotein Eb
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0070001 (aspartic-type peptidase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007267 (cell-cell signaling), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048066 (developmental pigmentation), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0050790 (regulation of catalytic activity), GO:0001666 (response to hypoxia), GO:1901564 (organonitrogen compound metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0060255 (regulation of macromolecule metabolic process), GO:0001945 (lymph vessel development), GO:0043170 (macromolecule metabolic process), GO:0007626 (locomotory behavior), GO:0009888 (tissue development), GO:0036303 (lymph vessel morphogenesis), GO:0060322 (head development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007632 (visual behavior), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0050931 (pigment cell differentiation), GO:0043603 (amide metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0001946 (lymphangiogenesis), GO:0009416 (response to light stimulus), GO:0007634 (optokinetic behavior), GO:0006518 (peptide metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0016055 (Wnt signaling pathway), GO:0051336 (regulation of hydrolase activity), GO:0036269 (swimming behavior), GO:0001944 (vasculature development), GO:0030318 (melanocyte differentiation), GO:0042982 (amyloid precursor protein metabolic process), GO:0061053 (somite development), GO:0007219 (Notch signaling pathway), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0072359 (circulatory system development), GO:0036293 (response to decreased oxygen levels), GO:0007417 (central nervous system development), GO:0060429 (epithelium development), GO:0071632 (optomotor response), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0060070 (canonical Wnt signaling pathway), GO:0050435 (amyloid-beta metabolic process), GO:0042987 (amyloid precursor protein catabolic process), GO:0052548 (regulation of endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)