wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: RNA-binding protein 24-A-like Protein (D6W891)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Cytoplasm. Nucleus
Sequence: MRDRRSTFTKEYINNVVNPLGNRPTRPTENHTTTSSERSAASDPSEDQSAKMLMPSGLPANEADGLGLGGLGTNTNTNNGVQHKDTTWTKLFVGGLPYHTTDQSLREHFSVYGEIEEAVVITDRQTGKSRGYGFVIMGDKSSSDRACKDANPIIDGRKANVNLAILGAKPRGNAQTGFPFQGIRAGYPALLPGQYGMPPGYVYQSPYLTAAAPGSLVPLPATQLTHAAAVAAATSQFYEYQNAAAVAAAAAAPYTGQYANGFDAYTPYTGAAGAAGYLPYTYTLPQTPGLPTATAGAFPAIPYQAAAQAQTLQEARLQ
InterPro domains: - IPR000504: RNA recognition motif domain (domain) [89-166]
- IPR050886: RNA-binding_regulatory_proteins (family) [81-277]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [84-184]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [80-174]
Interaction partners: - CUGBP Elav-like family member 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000380 (alternative mRNA splicing, via spliceosome), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: non-specific serine/threonine protein kinase (A0A139WK05)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Cytoplasm
Sequence: MSPYSRYRPLPGSDGISVLQTPPGCRPTPPTACRFLRWISKFSPQPVNKQTLGVLDMTATENTIRFSVHTLDKATKAKVTLENYYTNLIAQHVERKQRLAKLEESLKDDSLSEEQKHEKRLQHAQKETEFLRLKRSRLGVEDFEPLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVAHVRAERDILVEADHQWVVKMYYSFQDPINLYLIMEFLPGGDMMTLLMKKDTLSEEFTQFYIAETALAIDSIHKLGFIHRDIKPDNLLLDAKGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIITSSPMDSKRRAESWKKNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLIGYPPFCSENPQDTYRKVMNWRETLVFPAEVPISEEAKDTIIKFCCEAERRLGSQKGIEDLKIIPFFRGVDWEHIRERPAAIPVEVKSIDDTSNFDDFPDVKLEIPSAPMPQDGEVNYKDWVFINYTFKRFEGLTQRGTPTKK
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [262-274]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [129-460]
- IPR050839: Rho-associated Serine/Threonine Kinase (family) [97-501]
- IPR017441: Protein kinase, ATP binding site (binding_site) [149-172]
- IPR017892: Protein kinase, C-terminal (domain) [458-500]
- IPR000719: Protein kinase domain (domain) [143-439]
- IPR000961: AGC-kinase, C-terminal (domain) [440-510]
Interaction partners: - MOB kinase activator-like 1
- Protein furry homolog-like
- MOB kinase activator-like 2
- cAMP-dependent protein kinase type I regulatory subunit-like Protein
- protein-tyrosine-phosphatase
- protein-tyrosine-phosphatase
- Alpha-endosulfine-like Protein
- DIS3-like exonuclease 2
- Exosome complex exonuclease RRP44-like Protein
- non-specific serine/threonine protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Golgi phosphoprotein 3 homolog rotini-like Protein (D6W8D1)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
Sequence: MNRSEGLVQRRNIIRDSGEGVKESQNNEKKQEHDEDIDEGDSKETRLTLMEEVLLLGLKDKEGYTSFWNDCISSGLRGCILIELGLRGRVELERAGMRRKALLTRKLILKNDTPTGDVLLDEALKHLKETDPPETVQSWIEYLSGETWNPLKLRYQLKNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTDNVTKSRLIKKIQDAVLTKWVNDPQRMDKRMLALIFLAHASDVLENAFAPLNDDDYELAIKRVRELLDLDFEQESVKPNTSEVLWAVFAAFTK
InterPro domains: - IPR008628: Golgi phosphoprotein 3-like (family) [2-285]
- IPR038261: Golgi phosphoprotein 3-like domain superfamily (homologous_superfamily) [38-285]
Interaction partners: - Phosphatidylinositol-3-phosphatase SAC1
- Nuclear pore membrane glycoprotein 210-like Protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0019899 (enzyme binding), GO:0035091 (phosphatidylinositol binding), GO:0051020 (GTPase binding), GO:0070300 (phosphatidic acid binding), GO:0031267 (small GTPase binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding), GO:0010314 (phosphatidylinositol-5-phosphate binding), GO:0070273 (phosphatidylinositol-4-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0001906 (cell killing), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0031640 (killing of cells of another organism), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0005802 (trans-Golgi network)
Protein: SoxNeuro (D6WK03)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Nucleus
Sequence: MLTMETDLKGGSLHATMPPHHAIQSYGSLAPMHMGQHPHQMHHQPQPPQPPPQLHHHQPPSTQHQTQNNNNNNTKSQNMERVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLLKKDKYPLGASSLIPTSDPTRTAPSAVQQVSSRDMYQMPNGYMPNGYMMHDPGAYQQQYTGSNYGRYDMSQMQYMNGYGYGATVPQSAGSPYGMQQTSSHSPSGSSIKSEPVSPSSGLHTPTPGVKREYGQQQQPQGDLRQMISMYLPTDGSQHMQQYSASPDPLGPGPLAPLAHM
InterPro domains: - IPR009071: High mobility group box domain (domain) [81-151]
- IPR022097: Transcription factor SOX (family) [151-235]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [69-157]
- IPR050140: SRY-related HMG-box transcription factor-like (family) [36-318]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0044093 (positive regulation of molecular function), GO:0080090 (regulation of primary metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex)
Protein: Gamma-secretase subunit Aph-1-like Protein (D6WLF1)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MTLVEFFGCTFLAFGPPFAMFVFTIAHDPVRIIILIAAAFFWLVSLLLSSLWWYIVVPLRQDLAFGVVFSVFFQETFRYIIYKILRKAENGLKKITDDSTQLIENKHILAYVSGLGFGIISGAFSLVNILADAVGPGTMGLKGGNEMFFLTSAATGLCFTLLHTFWGVIFFNALDNSNKCYVGVVVVSHLLSSCITLLNFKVGPAGTLIPLYFNLVLMGLMAYRVAGGSYASFKSCITFK
InterPro domains: - IPR009294: Gamma-secretase subunit Aph-1 (family) [1-238]
Interaction partners: - Nicastrin
- Gamma-secretase subunit PEN-2
- Presenilin
- Neurogenic locus Notch protein-like Protein
- Congested-like trachea protein
- Calcium-independent phospholipase A2-gamma-like Protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:1901701 (cellular response to oxygen-containing compound), GO:1901653 (cellular response to peptide), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0008286 (insulin receptor signaling pathway), GO:0032869 (cellular response to insulin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Protein cortex-like Protein (D6WE73)
Organism: Tribolium castaneum (Red flour beetle)
Sequence: MLRLSNSVRNSCDRFIPLRLNDEISPDPSNFDPLDHEVLENTGFINYAKIRYNRNNYKNALRSALLPYEPKVLNFFPPKKFKVKKTPGMEHTWPVKPREKPVIGLPKTVLDMPQFDSTIFHHVCDWSSEGCIATIFQNEVHIWNHVTQRRIRITSTTHRIEYSIKWKNGGTQFAVGLFPSSVGIWDVVANKLICWESCGHYAHKCKVFALEWINAQLLVTGCSLGSLKVFNSELNKIRESTFAHTGAILTIVRSCDGRFIATTGMDKMMIVWRIPTLEKHFTFETDTISRAVAWHPWRGSLLAVGVGQRNGHIVIFNINKKSSIAEEKFTYRNATVNSLTFNPISGELVASYFVRDARDRRKGVGVVVVFSNIDRIEEELHLHDGPILYLLWGNKGRNLASASADENLCIWDFFGKMDEQSQNGRKKKEKNTPTSSVLRSTIR
InterPro domains: - IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [133-413]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [70-415]
- IPR001680: WD40 repeat (repeat) [194-412]
- IPR033010: WD repeat Cdc20/Fizzy (family) [11-427]
Interaction partners: - Cell division cycle protein 16 homolog-like Protein
- Anaphase-promoting complex subunit 5
- Cyclosome subunit 8
- Anaphase-promoting complex subunit 10
- Anaphase-promoting complex subunit 4
- Shattered
- Anaphase-promoting complex subunit 2
- Mitotic spindle assembly checkpoint protein MAD2A
- Cell division cycle protein 20 homolog
- Budding uninhibited by benzimidazoles 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process), GO:0031145 (anaphase-promoting complex-dependent catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Transcription factor IIIA-like Protein (D2A389)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Nucleus
Sequence: MDSSGGSDRGSDVDAIPTKKTFKCTHPGCNASFSKIRKLVIHSRRHTGERPYICDEPGCNKTYTNSSHLVRHKKTSHGPKESQTLVCEVPGCGLVLANKYSLKKHCARKHNSELYRFKCGECNQGFHRKKLLQQHAYIHTGEANFSCDKCDLKFTTGYNLSKHKRSHRIYTCDCKEEFHRWSLLLAHKKTCENGNQFRCDVCSRTFNRKNNFDQHKTIHKAQNEKLVFPCTFPDCKRFYFHKRNLTHHINVFHEKKNADVRYNCTYPNCQLVLKTKKCLKVHLQTHFKWKVKKERQTRRDKGKPKKSMVSVLLGQEFQQNKENENQTPCTDEILGEELQENKGNEDEMHCPDELTDDCLLEKCNVTLEEFNKKLIASR
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [22-286]
- IPR050636: C2H2-type zinc finger domain-containing protein (family) [19-258]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [32-219]
Interaction partners: - Peptidase C50 domain-containing protein
- Myb-like domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006996 (organelle organization), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process), GO:0000723 (telomere maintenance), GO:0051276 (chromosome organization), GO:0032200 (telomere organization), GO:0006278 (RNA-templated DNA biosynthetic process), GO:0010833 (telomere maintenance via telomere lengthening), GO:0007004 (telomere maintenance via telomerase)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Germ cell-less (D6WFR4)
Organism: Tribolium castaneum (Red flour beetle)
Sequence: MGLIYSSSSIVDNVTNYISGRKRKYSDSEDDEVNKVIDIALHTPKRKKLVSTAQYIYQALFEEGKNSDITVCALGEEFYLHKIYLCQSPYFASMFGGSWLEATKKYIHIDVVDPLITIDSLKVVFGSLYNCEITLNPLQIVSTLATATMFQLDGLIEKCTEVMLETINPKSSLEYYNAACQYGDKKLQDVCFKWFLVNLMTYYFSHPVVNLKSIPIPLMTKLVAHPDLFVMQTEYSIYVLLKYWVYILTHPEMGDETPSSKEVNNFFCSRKNEMPYLLTDEGRKFVPVFQGLRIPNLISHQMDVELVLHDNIIPHSWLNPVVLQQWKQVLRVNQNDDKGPSEVSNELFLETSLRCGRILMVNERHVWRWTGFHFGMDLLMMTDGYTVSVKRNHRSEFEQLLSFQTSRHIAIRVTVVKLNEQRQIVYSKQSEILKLSLAKGEEVQIMALDKDLEYPIIISANILYTSPDSQEINQEEVVQTVS
InterPro domains: - IPR043380: Germ cell-less protein-like (family) [6-473]
- IPR000210: BTB/POZ domain (domain) [58-167]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [43-195]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0140767 (enzyme-substrate adaptor activity), GO:1990756 (ubiquitin ligase-substrate adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140535 (intracellular protein-containing complex), GO:0043229 (intracellular organelle), GO:1990234 (transferase complex), GO:0043227 (membrane-bounded organelle), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0031463 (Cul3-RING ubiquitin ligase complex), GO:0005634 (nucleus)
Protein: Proton-coupled amino acid transporter 4-like Protein (D2A036)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MAENRKEKFASTYTVDNFNSTAELANNECNIPVSGADIITDKVYVPYDHRNVEHPNTFSGALMHICKSSLGTGILAIPSAVKAAGIIVGVVGTVLTGILCTHTIHLLIFASQEICKKAKLPMLGFAETAHAVFKYGPRHIQPFANFAKNFVDFCLLLTYCSGNAVYVVFITGNIQKVVNYYQESVADWPLQYYMLILLVPLTLCCQVRQLKHLVPFSIIANVTMVTAFLITLYYMFSGIGDIDMEERKLFNDISQFPLFFSTVIFAMEGIGTMLPIENTMIKQQFIGCPGVLNFAMAFVVTLYTLIGLFGYLRFGDKVSSNVIENLPTDEIAAQVARLCVATAVFFTFMLQFYVPCEITWRKVSSKIPKNYHNIAQIVMRTLLVLFITAIGAAVPKLDVIIGLVGSICLSTLGLFIPAAIDLTLNLGENGDFGVMKWRLWKDILIAILSWFALFSGSYYAIKELIEG
InterPro domains: - IPR013057: Amino acid transporter, transmembrane domain (domain) [57-461]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0098739 (import across plasma membrane), GO:0006810 (transport), GO:0089718 (amino acid import across plasma membrane), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0003333 (amino acid transmembrane transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)