Protein: Drebrin (Developmentally-regulated brain protein) (Q9QXS6)
Organism: Mus musculus (Mouse)
Function: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q16643}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q16643}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q16643}. Cell junction {ECO:0000250|UniProtKB:Q16643}. Cell projection {ECO:0000269|PubMed:24720729}. Cell projection, growth cone {ECO:0000269|PubMed:24720729}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (By similarity). Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (PubMed:24720729). {ECO:0000250|UniProtKB:Q16643, ECO:0000269|PubMed:24720729}.
Sequence: MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDARLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQSLEAEEAKRRLKEQSIFGDQRDEEEESQMKKSESEVEEAAAIIAQRPDNPREFFRQQERVASASGGSCDAPAPAPFNHRPGRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPIAEQIERALDEVTSSQPPPPPPPPPPTQEAQETTPSLDEELSKEAKVTAAPEVWAGCAAEPPQAQEPPLLQSSPLEDSMCTESPEQAALAAPAEPAASVTSVADVHAADTIETTTATTDTTIANNVTPAAASLIDLWPGNGEEASTLQAEPRVPTPPSGAEASLAEVPLLNEAAQEPLPPVGEGCANLLNFDELPEPPATFCDPEEEVGETLAASQVLTMPSALEEVDQVLEQELEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEEPCAKVPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [2-135]
- IPR002108: Actin-depolymerising factor homology domain (domain) [3-134]
Interaction partners: - Microtubule-associated protein RP/EB family member 3
- Homer protein homolog 2
- Gap junction alpha-1 protein
- Zinc finger, MYND-type containing 8
- Neurabin-2
- Adenylyl cyclase-associated protein 2
- Nexilin
- Cofilin-1
- Cofilin-2
- Disks large homolog 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0045927 (positive regulation of growth), GO:0003006 (developmental process involved in reproduction), GO:0048871 (multicellular organismal-level homeostasis), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0051235 (maintenance of location), GO:0065009 (regulation of molecular function), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0060627 (regulation of vesicle-mediated transport), GO:0051098 (regulation of binding), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0003013 (circulatory system process), GO:0043114 (regulation of vascular permeability), GO:0044087 (regulation of cellular component biogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0042391 (regulation of membrane potential), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0007548 (sex differentiation), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0048639 (positive regulation of developmental growth), GO:0009967 (positive regulation of signal transduction), GO:0007276 (gamete generation), GO:0050773 (regulation of dendrite development), GO:0045597 (positive regulation of cell differentiation), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0046887 (positive regulation of hormone secretion), GO:0060341 (regulation of cellular localization), GO:0001558 (regulation of cell growth), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0010817 (regulation of hormone levels), GO:0030307 (positive regulation of cell growth), GO:0010817 (regulation of hormone levels), GO:0030307 (positive regulation of cell growth), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:0060249 (anatomical structure homeostasis), GO:0046883 (regulation of hormone secretion), GO:0048872 (homeostasis of number of cells), GO:0046883 (regulation of hormone secretion), GO:0048872 (homeostasis of number of cells), GO:0045165 (cell fate commitment), GO:2000026 (regulation of multicellular organismal development), GO:0010646 (regulation of cell communication), GO:0016358 (dendrite development), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:1903532 (positive regulation of secretion by cell), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:0043254 (regulation of protein-containing complex assembly), GO:0045773 (positive regulation of axon extension), GO:0043254 (regulation of protein-containing complex assembly), GO:0071705 (nitrogen compound transport), GO:0022409 (positive regulation of cell-cell adhesion), GO:0051246 (regulation of protein metabolic process), GO:0010810 (regulation of cell-substrate adhesion), GO:1904951 (positive regulation of establishment of protein localization), GO:0022407 (regulation of cell-cell adhesion), GO:0070201 (regulation of establishment of protein localization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0071702 (organic substance transport), GO:0032956 (regulation of actin cytoskeleton organization), GO:0050769 (positive regulation of neurogenesis), GO:0030334 (regulation of cell migration), GO:1902903 (regulation of supramolecular fiber organization), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0007399 (nervous system development), GO:0032231 (regulation of actin filament bundle assembly), GO:0015031 (protein transport), GO:1902905 (positive regulation of supramolecular fiber organization), GO:1902533 (positive regulation of intracellular signal transduction), GO:0050708 (regulation of protein secretion), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0150117 (positive regulation of cell-substrate junction organization), GO:1901890 (positive regulation of cell junction assembly), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0061458 (reproductive system development), GO:0034097 (response to cytokine), GO:0031344 (regulation of cell projection organization), GO:0071310 (cellular response to organic substance), GO:1901888 (regulation of cell junction assembly), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0032880 (regulation of protein localization), GO:0051960 (regulation of nervous system development), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0050714 (positive regulation of protein secretion), GO:0030855 (epithelial cell differentiation), GO:0051099 (positive regulation of binding), GO:0010639 (negative regulation of organelle organization), GO:0050770 (regulation of axonogenesis), GO:0031346 (positive regulation of cell projection organization), GO:0051247 (positive regulation of protein metabolic process), GO:0033043 (regulation of organelle organization), GO:0051046 (regulation of secretion), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0030182 (neuron differentiation), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0032092 (positive regulation of protein binding), GO:1905475 (regulation of protein localization to membrane), GO:0051494 (negative regulation of cytoskeleton organization), GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading), GO:0032271 (regulation of protein polymerization), GO:0050772 (positive regulation of axonogenesis), GO:0071345 (cellular response to cytokine stimulus), GO:0007010 (cytoskeleton organization), GO:0097746 (blood vessel diameter maintenance), GO:0110020 (regulation of actomyosin structure organization), GO:0051896 (regulation of protein kinase B signaling), GO:0035296 (regulation of tube diameter), GO:0043410 (positive regulation of MAPK cascade), GO:0050767 (regulation of neurogenesis), GO:0032232 (negative regulation of actin filament bundle assembly), GO:0030838 (positive regulation of actin filament polymerization), GO:0043408 (regulation of MAPK cascade), GO:1900024 (regulation of substrate adhesion-dependent cell spreading), GO:0033365 (protein localization to organelle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0030427 (site of polarized growth), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099571 (postsynaptic cytoskeleton), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0030027 (lamellipodium), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0070161 (anchoring junction), GO:0030426 (growth cone), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0098858 (actin-based cell projection), GO:0097060 (synaptic membrane), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0044295 (axonal growth cone), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0060076 (excitatory synapse), GO:0098984 (neuron to neuron synapse), GO:0099512 (supramolecular fiber), GO:0005911 (cell-cell junction), GO:0099513 (polymeric cytoskeletal fiber), GO:0032279 (asymmetric synapse), GO:0030175 (filopodium), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0044309 (neuron spine), GO:0015629 (actin cytoskeleton), GO:0005884 (actin filament)