Protein: Lethal giant larvae 1 (Lethal(2) giant larvae protein homolog 1) (I0BWE2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Sequence: MMKFRFRRQGNDPHREKIKQDLFAFNKTVEHGFPNQPSALAYDPKLQLMAIGTKSGAIKIYGAPGVEMTGLHKDTAAVTQIHFLCGQGRILSLLDDNTIHLWEIVQRENRSHLLEVHSFNLPGRPGIESTSATRVTVMLLNLSCNLLALGTEGGGVHFLELPTLTLLNKSLFQDEIMQSVPEEYKCGKSLGPVESLQEHPKDSDKILIGYSRGLVVLWDLSSRHVDNLFLGKQQLESLVWERSGNSFVSSHSDGGYMVWAVSSSNPCTHDPVSSTIPYGPFPCKAVNKILWRTTESGAPLVLFSGGMPRASYGDRHCLTILQDSSHVTLDFTSRVIDFFTIHCTDTEKDFDEPSALVVLLEEELVVIDLQMPGWPTVPAPYLAPLHSSAITCSCHISNVPPKLWERVISAGQQQCPLQNYENWPICGGKNLAPDPKQKELLLTGHEDGTVRFWEASGVSLKPLYKLSTASIFQTDCEHNDSLTQAGEEEWPPFRKVGCFDPYSDDPRLGIQKISLCKYSGKLVVAGTAGQVIVMVLGDEKSDHMIDVATVDLLQDREGFTWKGHDRLPPKSGSVVFAPGFQPVVLVQCLPPAAVTAVTLHAEWNLIAFGTSHGFGLFDYHRRSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRVVVNSPTSKVQEANAHLADHDAEVTPVQRRIEPRSADDSLSGVVRCLCFADTFLRDGTHHGPTMWAGTNSGSVYAYAPDVPSQEKFSEQSVEALLGKEIQLMHRAPVVSIAVLDGRGNPLPEPYEVSRDLAKAPDMQGSHSVLIASEEQFKVFMLPKVSAKTKFKLTAHEGCRVRKVALANFTSVSSEDYSENALVCLTNMGDIHMFSVPALRPQVRYDCVRKEDISGIASCVFTKTGQGFYLISPSEYERFSLSARVITEPLCGVDIERPHDVSAHSSSTTLPPQANGTHKSQAESKSAETEDLLEEMRSVLSSPILDSPNSSADITLDTTGDLTVEDVKDFLMTVDEAENNFRNITEEDGRSAGILIN
InterPro domains: - IPR013577: Lethal giant larvae homologue 2 (domain) [275-375]
- IPR001680: WD40 repeat (repeat) [22-454]
- IPR000664: Lethal(2) giant larvae protein (family) [17-712]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [10-490]
- IPR013905: Lethal giant larvae (Lgl)-like, C-terminal domain (domain) [732-926]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [35-915]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0003407 (neural retina development), GO:0016043 (cellular component organization), GO:0060041 (retina development in camera-type eye), GO:0048882 (lateral line development), GO:0030030 (cell projection organization), GO:0008593 (regulation of Notch signaling pathway), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0022607 (cellular component assembly), GO:0048925 (lateral line system development), GO:0001654 (eye development), GO:0030031 (cell projection assembly), GO:0048884 (neuromast development), GO:0048916 (posterior lateral line development), GO:0150063 (visual system development), GO:0048881 (mechanosensory lateral line system development), GO:0043010 (camera-type eye development), GO:0048919 (posterior lateral line neuromast development), GO:0048915 (posterior lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016323 (basolateral plasma membrane)