Protein: Protein argonaute-2 (Q86B39)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MPGDSLTSSSFMPDGGAETSSSSQLGGSAHGAIGTKPDAGVQFQCPVRPNHGVEGRSILLRANHFAVRIPGGSVQHYQIDVFPDKCPRRVNREVIGCLISSFSKYFTNIRPVYDGKRNMYTREPLPIGTEPMNFEVTLPGDSAVERKFSVTMKWIGQVCLSALDDAMEGRVRQVPHEAVQSIDVILRHLPSLKYTPVGRSFFTPPGVMKPGMQMHQESKLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYRAMPVIEFVAEVLELPVQALAERRALSDAQRVKFTKEIRGLKIEITHCGAVRRKYRVCNVTRRPAQTQTFPLQLETGQTIECTVAKYFFDKYRIQLKYPHLPCLQVGQEQKHTYLPPEVCDIVPGQRCLKKLTDVQTSTMIKATARSAPEREREICKLVSKAELSADPFAHEFGITINPAMTEVKGRVLSAPKLLYGGRHRATTALPNQGVWDMRGKQFHTGMEVRTWAIACFAQQSHVKENDLRMFTTQLQRISTDAGMPIIGTPMFCKYASGVEQVEPMFKYLKQTYSAIQLIVVVLPGKTPIYAEVKRVGDTVLGIATQCVQAKNAIRTTPQTLSNLCLKMNVKLGGVNSILLPNVRPRIFNEPVIFLGCDITHPAAGDTRKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIITDLTYMVRELLVQFYRNTRFKPARIVVYRDGVSEGQLFNVLQYELRAIREACVMLESGYQPGITFIAVQKRHHTRLFAADKADQVGKAFNIPPGTTVDVGITHPTEFDFFLCSHAGIQGTSRPSHYHVLWDDNDLTADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDRDHGSGEEGSQPSGTSSEDTTLSSMAKAVQVHPDSNNVMYFA
InterPro domains: - IPR032472: Argonaute linker 2 domain (domain) [403-449]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [543-849]
- IPR032473: Protein argonaute, Mid domain (domain) [460-540]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [612-891]
- IPR003100: PAZ domain (domain) [257-399]
- IPR003165: Piwi domain (domain) [547-848]
- IPR014811: Argonaute, linker 1 domain (domain) [195-255]
- IPR032474: Protein argonaute, N-terminal (domain) [56-186]
- IPR036085: PAZ domain superfamily (homologous_superfamily) [58-413]
- IPR045246: Argonaute-like, PIWI domain (domain) [421-847]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0003723 (RNA binding), GO:0004540 (ribonuclease activity), GO:0003725 (double-stranded RNA binding), GO:0003727 (single-stranded RNA binding), GO:0061980 (regulatory RNA binding), GO:0004521 (RNA endonuclease activity), GO:0004519 (endonuclease activity), GO:0016891 (RNA endonuclease activity, producing 5'-phosphomonoesters), GO:0016894 (endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters), GO:0016893 (endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0035198 (miRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0009791 (post-embryonic development), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0043487 (regulation of RNA stability), GO:0044085 (cellular component biogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009894 (regulation of catabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0002164 (larval development), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043488 (regulation of mRNA stability), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0051248 (negative regulation of protein metabolic process), GO:0050779 (RNA destabilization), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0034248 (regulation of amide metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0043933 (protein-containing complex organization), GO:0031329 (regulation of cellular catabolic process), GO:0002119 (nematode larval development), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0017148 (negative regulation of translation), GO:0016070 (RNA metabolic process), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0061013 (regulation of mRNA catabolic process), GO:0065003 (protein-containing complex assembly), GO:0061014 (positive regulation of mRNA catabolic process), GO:0016441 (post-transcriptional gene silencing), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0022618 (ribonucleoprotein complex assembly), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:0061157 (mRNA destabilization), GO:1903311 (regulation of mRNA metabolic process), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:1903313 (positive regulation of mRNA metabolic process), GO:0010608 (post-transcriptional regulation of gene expression), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0070922 (RISC complex assembly), GO:0035194 (RNA-mediated post-transcriptional gene silencing), GO:0035196 (miRNA processing), GO:0035195 (miRNA-mediated gene silencing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0031332 (RNAi effector complex), GO:0016442 (RISC complex)