Protein: Arylsulfatase K (ASK) (EC 3.1.6.1) (Glucuronate-2-sulfatase) (EC 3.1.6.18) (Telethon sulfatase) (Q6UWY0)
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate. Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate.
Subcellular location: Secreted {ECO:0000269|PubMed:23986440}. Lysosome {ECO:0000269|PubMed:23986440}.
Sequence: MLLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASAHVPLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDGASILPQLFDLSSDPDELTNVAVKFPEITYSLDQKLHSIINYPKVSASVHQYNKEQFIKWKQSIGQNYSNVIANLRWHQDWQKEPRKYENAIDQWLKTHMNPRAV
InterPro domains: - IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [30-507]
- IPR047892: Arylsulfatase K (family) [32-447]
- IPR051849: Glycosaminoglycan-degrading sulfatase (family) [2-531]
- IPR000917: Sulfatase, N-terminal (domain) [32-370]
Interaction partners: - Arylsulfatase I
- Arylsulfatase J
- Arylsulfatase B
- Arylsulfatase G
- Formylglycine-generating enzyme
- Arylsulfatase H
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0009057 (macromolecule catabolic process), GO:0044273 (sulfur compound catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009100 (glycoprotein metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0006022 (aminoglycan metabolic process), GO:0006026 (aminoglycan catabolic process), GO:0006029 (proteoglycan metabolic process), GO:0030203 (glycosaminoglycan metabolic process), GO:0006516 (glycoprotein catabolic process), GO:0006027 (glycosaminoglycan catabolic process), GO:0030167 (proteoglycan catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0005788 (endoplasmic reticulum lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0043202 (lysosomal lumen), GO:0005766 (primary lysosome)