Protein: Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) (P40189)
Organism: Homo sapiens (Human)
Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19915009}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:24629561}.
Sequence: MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ
InterPro domains: - IPR050379: Type I Cytokine Receptor (family) [284-815]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [24-610]
- IPR003961: Fibronectin type III (domain) [126-613]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [23-612]
- IPR010457: Immunoglobulin C2-set-like, ligand-binding (domain) [27-120]
- IPR003529: Long hematopoietin receptor, Gp130 family 2, conserved site (conserved_site) [404-457]
Interaction partners: - Interleukin-6 receptor subunit alpha
- Interleukin-6
- Leukemia inhibitory factor
- Interleukin-27 receptor subunit alpha
- Tyrosine-protein kinase JAK1
- Oncostatin-M
- Interleukin-11
- Leukemia inhibitory factor receptor
- Ciliary neurotrophic factor
- Interleukin-27 subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0032879 (regulation of localization), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0009991 (response to extracellular stimulus), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:2000145 (regulation of cell motility), GO:0006629 (lipid metabolic process), GO:0007584 (response to nutrient), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0051481 (negative regulation of cytosolic calcium ion concentration), GO:0044255 (cellular lipid metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0010817 (regulation of hormone levels), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0046883 (regulation of hormone secretion), GO:0034097 (response to cytokine), GO:0046486 (glycerolipid metabolic process), GO:0071310 (cellular response to organic substance), GO:0031667 (response to nutrient levels), GO:0030335 (positive regulation of cell migration), GO:0051046 (regulation of secretion), GO:0006638 (neutral lipid metabolic process), GO:0030334 (regulation of cell migration), GO:0019221 (cytokine-mediated signaling pathway), GO:0070741 (response to interleukin-6), GO:0014910 (regulation of smooth muscle cell migration), GO:0006639 (acylglycerol metabolic process), GO:0070102 (interleukin-6-mediated signaling pathway), GO:0071345 (cellular response to cytokine stimulus), GO:0014911 (positive regulation of smooth muscle cell migration), GO:0071354 (cellular response to interleukin-6), GO:0006641 (triglyceride metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)