Protein: Protein ORM1 (P53224)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Sequence: MTELDYQGTAEAASTSYSRNQTDLKPFPSAGSASSSIKTTEPVKDHRRRRSSSIISHVEPETFEDENDQQLLPNMNATWVDQRGAWIIHVVIIILLKLFYNLFPGVTTEWSWTLTNMTYVIGSYVMFHLIKGTPFDFNGGAYDNLTMWEQIDDETLYTPSRKFLISVPIALFLVSTHYAHYDLKLFSWNCFLTTFGAVVPKLPVTHRLRISIPGITGRAQIS
InterPro domains: - IPR007203: ORMDL family (family) [3-222]
Interaction partners: - Serine palmitoyltransferase 1
- Protein ORM2
- Serine palmitoyltransferase-regulating protein TSC3
- Serine palmitoyltransferase 2
- Phosphatidylinositol-3-phosphatase SAC1
- Ceramide synthase LAC1
- Ceramide synthase LAG1
- Serine/threonine-protein kinase YPK2/YKR2
- Serine/threonine-protein kinase YPK1
- Flippase kinase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0055082 (intracellular chemical homeostasis), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0055088 (lipid homeostasis), GO:0045833 (negative regulation of lipid metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0035966 (response to topologically incorrect protein), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0044087 (regulation of cellular component biogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051055 (negative regulation of lipid biosynthetic process), GO:1905038 (regulation of membrane lipid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006986 (response to unfolded protein), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0019216 (regulation of lipid metabolic process), GO:0090153 (regulation of sphingolipid biosynthetic process), GO:0046890 (regulation of lipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140534 (endoplasmic reticulum protein-containing complex), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005783 (endoplasmic reticulum), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)