Protein: Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Embryonic liver fodrin) (Fodrin beta chain) (Q62261)
Organism: Mus musculus (Mouse)
Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Endomembrane system {ECO:0000269|PubMed:15262991}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:15262991}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q01082}. Cell membrane {ECO:0000250|UniProtKB:Q01082}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000269|PubMed:15262991}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9927192}. Cell membrane {ECO:0000269|PubMed:9927192}; Peripheral membrane protein; Cytoplasmic side.
Sequence: MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYGKHLLGVEDLLQKHALVEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSNDVGHDEYSTQSLVKKHKDVAEEITNYRPTIDTLHEQASALPQAHAESPDVKGRLAGIEERCKEMAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHNGHPSEKEIRAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNREAASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLSERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIITDSSSLNAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHKAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNNMADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACEGRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTACIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPDPNTKVSEEAESQQWDTSKGDQVSQNGLPAEQGSPRMAGTMETSEMVNGAAEQRTSSKESSPVPSPTLDRKAKSALPAQSAATLPARTLETPAAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKSAASGIPYHSEVPVSLKEAICEVALDYKKKKHVFKLRLSDGNEYLFQAKDDEEMNTWIQAISSAISSDKHDTSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [14-283]
- IPR001849: Pleckstrin homology domain (domain) [2196-2308]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [56-154]
- IPR016343: Spectrin, beta subunit (family) [1-2363]
- IPR018159: Spectrin/alpha-actinin (repeat) [305-2162]
- IPR001605: Pleckstrin homology domain, spectrin-type (domain) [2199-2299]
- IPR041681: Pleckstrin homology domain 9 (domain) [2200-2302]
- IPR002017: Spectrin repeat (repeat) [303-2096]
- IPR001715: Calponin homology domain (domain) [54-278]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [2193-2310]
Interaction partners: - Spectrin alpha chain, non-erythrocytic 1
- Ankyrin-3
- Ankyrin-2
- Ankyrin-1
- Mothers against decapentaplegic homolog 3
- Spectrin alpha chain, erythrocytic 1
- Band 4.1-like protein 3
- TRIO and F-actin-binding protein
- Mothers against decapentaplegic homolog 4
- Xin actin-binding repeat-containing protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0051050 (positive regulation of transport), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0030029 (actin filament-based process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0007626 (locomotory behavior), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0055006 (cardiac cell development), GO:0010562 (positive regulation of phosphorus metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0055001 (muscle cell development), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0030163 (protein catabolic process), GO:0031532 (actin cytoskeleton reorganization), GO:0006796 (phosphate-containing compound metabolic process), GO:0090257 (regulation of muscle system process), GO:0030239 (myofibril assembly), GO:1903522 (regulation of blood circulation), GO:0030855 (epithelial cell differentiation), GO:0036211 (protein modification process), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0043412 (macromolecule modification), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0051247 (positive regulation of protein metabolic process), GO:0043269 (regulation of monoatomic ion transport), GO:0035051 (cardiocyte differentiation), GO:0051174 (regulation of phosphorus metabolic process), GO:0007507 (heart development), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0006468 (protein phosphorylation), GO:0010959 (regulation of metal ion transport), GO:0055013 (cardiac muscle cell development), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:0007519 (skeletal muscle tissue development), GO:0007010 (cytoskeleton organization), GO:0008016 (regulation of heart contraction), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:0001885 (endothelial cell development), GO:0003158 (endothelium development), GO:0031401 (positive regulation of protein modification process), GO:0010498 (proteasomal protein catabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0060977 (coronary vasculature morphogenesis), GO:0055013 (cardiac muscle cell development), GO:0051924 (regulation of calcium ion transport), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:1905475 (regulation of protein localization to membrane), GO:0045862 (positive regulation of proteolysis), GO:0051146 (striated muscle cell differentiation), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0043025 (neuronal cell body), GO:0005886 (plasma membrane), GO:0099571 (postsynaptic cytoskeleton), GO:0098590 (plasma membrane region), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0070161 (anchoring junction), GO:0016324 (apical plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0060076 (excitatory synapse), GO:0005911 (cell-cell junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0098978 (glutamatergic synapse), GO:0005856 (cytoskeleton), GO:0098688 (parallel fiber to Purkinje cell synapse)