Protein: Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial (AtP5CDH) (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 12 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) (Q8VZC3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the inhibition of programmed cell death by converting the toxic proline catabolism intermediate (s)-1-pyrroline-5-carboxylate (P5C) to glutamate.
Subcellular location: Mitochondrion matrix {ECO:0000305|PubMed:11532180}.
Sequence: MYRVFASRALRAKSLCDKSSTSLASLTLSRLNHSIPFATVDAEELSGAHPAEVQSFVQGKWIGSSNHNTLLDPLNGEPFIKVAEVDESGTQPFVDSLSQCPKHGLHNPFKSPERYLLYGDISTKAAHMLALPKVADFFARLIQRVAPKSYQQAAGEVFVTRKFLENFCGDQVRFLARSFAIPGNHLGQQSHGYRWPYGPVTIVTPFNFPLEIPLLQLMGALYMGNKPLLKVDSKVSIVMEQMMRLLHYCGLPAEDVDFINSDGKTMNKILLEANPRMTLFTGSSRVAEKLALDLKGRIRLEDAGFDWKVLGPDVQEVDYVAWQCDQDAYACSGQKCSAQSMLFVHENWSKTPLVSKLKELAERRKLEDLTIGPVLTFTTEAMLEHMENLLQIPGSKLLFGGKELKNHSIPSIYGALEPTAVYVPIEEILKDNKTYELVTKEIFGPFQIVTEYKKDQLPLVLEALERMHAHLTAAVVSNDPIFLQEVIGNSVNGTTYAGLRGRTTGAPQNHWFGPAGDPRGAGIGTPEAIKLVWSCHREVIYDYGPVPQGWELPPST
InterPro domains: - IPR016160: Aldehyde dehydrogenase, cysteine active site (conserved_site) [329-340]
- IPR015590: Aldehyde dehydrogenase domain (domain) [124-496]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [51-302]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [53-523]
- IPR044638: Aldehyde dehydrogenase family 7 member A1-like (family) [32-555]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [309-497]
Interaction partners: - Delta-1-pyrroline-5-carboxylate synthase B
- Ornithine aminotransferase, mitochondrial
- Proline dehydrogenase 1, mitochondrial
- Delta-1-pyrroline-5-carboxylate synthase A
- Proline dehydrogenase 2, mitochondrial
- Pyrroline-5-carboxylate reductase
- Glutamate decarboxylase 5
- Glutamate decarboxylase 2
- Probable inactive poly [ADP-ribose] polymerase SRO5
- Glutamate decarboxylase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0000166 (nucleotide binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0017076 (purine nucleotide binding), GO:0046914 (transition metal ion binding), GO:0030554 (adenyl nucleotide binding), GO:0005507 (copper ion binding), GO:0051287 (NAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0009063 (amino acid catabolic process), GO:0009068 (aspartate family amino acid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0006553 (lysine metabolic process), GO:0006554 (lysine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)