Protein: Pheromone receptor transcription activator (Protein map1) (P78926)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: In response to mating-pheromone signaling or nitrogen starvation, it interacts with mat1-Pc. This activates the expression of one of two mating-type-specific genes sxa2 or map3, which leads to inactivation of the P-factor. May also interact with mat1-Mc.
Subcellular location: Nucleus.
Sequence: MMDERKLSNFQIDGEKAYTGSSQGNSYLEDRQKRQNTFTKRKAGIFKKANELALLTGSEVMVLVVSETGLVHTFSTPKLENVVKSPEGQKLITESLINATTDQNESQASQAKQSSAQLSDSESGYPLDHEEMRISEENGPSHIENLNFFSDIDNFSKTSAEEIASKLFSSVSPTHETLQFDHGLQNLEGFQANEHPEMFADHSIDFYNSNNVDIPALSMLTSQTSSSSTLNLPPEPASREVKIFPKQGKRIFSPSTGIDYETTGQHSVNSPPSTYKHRRSLNKSFATRSEPQTPRKNKIRDSLQSSPLNFPPRDRPPLIPISRIAVPSTIETEERQYRGNQKIINFYAKIFEPNSGLGTSSEGASSSFPDVDPNLAQNGVPYYSLPDIDHNQFDHLRR
InterPro domains: - IPR033897: SRF-like, MADS-box (domain) [26-94]
- IPR002100: Transcription factor, MADS-box (domain) [2-78]
- IPR050142: MADS-box/MEF2 Transcription Factor (family) [28-147]
- IPR036879: Transcription factor, MADS-box superfamily (homologous_superfamily) [27-102]
Interaction partners: - Serine/threonine-protein kinase sck1
- Serine/threonine-protein kinase sck2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)