Protein: DNA 3'-5' helicase (EC 5.6.2.4) (Q382S1)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MEHEQRVSEAGAKLKQPDVWPVEIEQILSALDNSQRVAVCENPSQPLLIIAGAGSGKTLTMASRIAFLILNNVAPQNILGLCFSRQAAETLRGRVASVLPPAMAGLAQKLKLKTFHAFGLECLRRYACIELTTEVYDARRQRDLAFTVVEKHAQYYKGVEAVVTLIDYVNKAKTKKDMRAGTELDPSRQPAYLFRFYESMLHEELNAVDFGDLEQRFLKALRPVRQRNDATSEGNNNSNSSSYSISADASSTLQLSPMAIQLRSQYTHFVVDEFQDLNEVQLECLALLAGDECRVTCVGDPNQCIYAWRGATAESFNLWRSRFPRSVIMKLETNYRSSAEIVCAVNQVTHLEQSSHKGQSGTNITLVKCKYAWEQLKLIPRIIERLRGRDRSLPYGSIAVLCRTHRTVRELVTALENDGIPVTELRRGAPNSVALVRALLSYLRLCIHPHSNVDVECVIRDAPNHFAAPSATKFIFALQAEALTRRLHLTTEQQLEGHYKCSYYTILRELVHNGFATSSDRLRTTKPQQKLLRTIIEVTAAAHEALSRFYCNIEDVVRSVAERAGFDDGSAGGAKIRHKVNNGMAGGGFNGIKRAKRPRCAPRVAAHLTDSVDVWEDVMNEGEEIMSSIPQLLLGACEAVQEQIIAEQSAVEADAINGDVLGFSDNRSVVKAEPDERSVGTHPDVPAAQPRYDPYTVLQRVIDEFLQLLPSDDFGPMKGPEALKPEERTVTVTTVHQAKGKEWPAVIIPCCYEGEFPIDTRKAEEKRVFYVAMSRAMESLVFLTAEQGPPTNASGRTADGDHALDSTGTEQQYVQLQMTPYLRPILHQVKVITMSAESEGQQE
InterPro domains: - IPR014017: UvrD-like DNA helicase, C-terminal (domain) [330-785]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [24-799]
- IPR000212: DNA helicase, UvrD/REP type (family) [28-795]
- IPR014016: UvrD-like helicase, ATP-binding domain (domain) [30-338]
- IPR013986: DExx box DNA helicase domain superfamily (homologous_superfamily) [133-210]
Interaction partners: - DNA repair protein RAD51 homolog
- Proliferating cell nuclear antigen
- DNA repair protein, putative
- S-phase kinase-associated protein, putative
- SKP1 component dimerisation domain-containing protein
- DNA 3'-5' helicase
- DNA 3'-5' helicase
- Crossover junction endonuclease MUS81
- Small ubiquitin protein, putative
- Flap endonuclease 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0004386 (helicase activity), GO:0008094 (ATP-dependent activity, acting on DNA), GO:0140097 (catalytic activity, acting on DNA), GO:0003678 (DNA helicase activity), GO:0043138 (3'-5' DNA helicase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0090304 (nucleic acid metabolic process), GO:0000723 (telomere maintenance), GO:0006310 (DNA recombination), GO:0051276 (chromosome organization), GO:0032200 (telomere organization), GO:0006312 (mitotic recombination), GO:0000722 (telomere maintenance via recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)