Protein: Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Q6FXL1)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Not known
Sequence: MSKVKVVNPIVEMDGDEQTRIIWHLIREKLILPFLDVDLKYYDLSIEYRDETNDKVTEDSALATLKYGVAVKCATITPDEARVEEFNLKEMWKSPNGTIRNILGGTVFREPIVIPRIPKLVPQWKEPIIIGRHAFGDQYRATDVVIPDEGEVRLVYKSKDGKTDIDIPVYNFPKEGGVAMMMYNTTESIRGFARASFNMALEHEMPLYSTTKNTILKKYDGKFKDTFESMYEAEYKEQFEAKGIWYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVESDIVAQGFGSLGLMTSVLISPDGKTFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGIIQRGKLDETADVVKFGELLERATVDTVQEDGIMTKDLALILGKTDRSAYVTTEEFIDAVENRIKSEFQKNF
InterPro domains: - IPR019818: Isocitrate/isopropylmalate dehydrogenase, conserved site (conserved_site) [271-290]
- IPR024084: Isopropylmalate dehydrogenase-like domain (domain) [5-399]
- IPR004790: Isocitrate dehydrogenase NADP-dependent (family) [1-410]
Interaction partners: - Aconitate hydratase, mitochondrial
- 2-oxoglutarate dehydrogenase, mitochondrial
- Isocitrate dehydrogenase subunit 1, mitochondrial
- Isocitrate dehydrogenase subunit 2, mitochondrial
- NAD-specific glutamate dehydrogenase
- Glutamate synthase
- Isocitrate dehydrogenase
- Isocitrate dehydrogenase
- Glutamate dehydrogenase
- Aspartate aminotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0043169 (cation binding), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding), GO:0004448 (isocitrate dehydrogenase [NAD(P)+] activity), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0006099 (tricarboxylic acid cycle), GO:0006091 (generation of precursor metabolites and energy), GO:0006082 (organic acid metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:0006097 (glyoxylate cycle), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0006102 (isocitrate metabolic process), GO:0045333 (cellular respiration), GO:0072350 (tricarboxylic acid metabolic process), GO:0009060 (aerobic respiration), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)