Protein: Mitochondrial tRNA methylthiotransferase CDK5RAP1 (A0A0S2Z5J9)
Organism: Homo sapiens (Human)
Sequence: MHPLQCVLQVQRSLGWGPLASVSWLSLRMCRAHSSLSSTMCPSPERQEDGARKDFSSRLAAGPTFQHFLKSASAPQEKLSSEVEDPPPYLMMDELLGRQRKVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKALKTRRPRSRVPLRIGILGCMAERLKEEILNREKMVDILAGPDAYRDLPRLLAVAESGQQAANVLLSLDETYADVMPVQTSASATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPIASILEEVKKLSEQGLKEVTLLGQNVNSFRDNSEVQFNSAVPTNLSRGFTTNYKTKQGGLRFAHLLDQVSRVDPEMRIRFTSPHPKDFPDEVLQLIHERDNICKQIHLPAQSGSSRVLEAMRRGYSREAYVELVHHIRESIPGVSLSSDFIAGFCGETEEDHVQTVSLLREVQYNMGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELITIFREEATKANQTSVGCTQLVLVEGLSKRSATDLCGRNDGNLKVIFPDAEMEDVNNPGLRVRAQPGDYVLVKITSASSQTLRGHVLCRTTLRDSSAYC
InterPro domains: - IPR006463: tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB (family) [98-577]
- IPR038135: Methylthiotransferase, N-terminal domain superfamily (homologous_superfamily) [100-234]
- IPR005839: Methylthiotransferase (family) [98-580]
- IPR058240: Radical SAM superfamily (homologous_superfamily) [245-494]
- IPR020612: Methylthiotransferase, conserved site (conserved_site) [252-272]
- IPR002792: TRAM domain (domain) [501-576]
- IPR006638: Elp3/MiaA/NifB-like, radical SAM core domain (domain) [248-487]
- IPR013848: Methylthiotransferase, N-terminal (domain) [100-220]
- IPR007197: Radical SAM (domain) [98-580]
- IPR023404: Radical SAM, alpha/beta horseshoe (homologous_superfamily) [246-504]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0051540 (metal cluster binding), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0051536 (iron-sulfur cluster binding), GO:0051539 (4 iron, 4 sulfur cluster binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1901360 (organic cyclic compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006450 (regulation of translational fidelity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0043412 (macromolecule modification), GO:0034250 (positive regulation of amide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0010628 (positive regulation of gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010467 (gene expression), GO:0010468 (regulation of gene expression), GO:0009451 (RNA modification), GO:0016070 (RNA metabolic process), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0140053 (mitochondrial gene expression), GO:0006417 (regulation of translation), GO:0045727 (positive regulation of translation), GO:0006396 (RNA processing), GO:0062125 (regulation of mitochondrial gene expression), GO:0010608 (post-transcriptional regulation of gene expression), GO:1900864 (mitochondrial RNA modification), GO:0000963 (mitochondrial RNA processing), GO:0034470 (ncRNA processing), GO:0000959 (mitochondrial RNA metabolic process), GO:0070131 (positive regulation of mitochondrial translation), GO:0070129 (regulation of mitochondrial translation), GO:0006400 (tRNA modification), GO:0070525 (tRNA threonylcarbamoyladenosine metabolic process), GO:0034660 (ncRNA metabolic process), GO:0090646 (mitochondrial tRNA processing), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen)