Protein: Sodium channel regulatory subunit beta-1 (Q00954)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11470829}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q07699}. Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000269|PubMed:11470829}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000269|PubMed:11470829}.
Sequence: MGTLLALVVGAVLVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [24-134]
- IPR027098: Sodium channel subunit beta-1/beta-3 (family) [5-218]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [27-124]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [20-151]
Interaction partners: - Sodium channel regulatory subunit beta-2
- Sodium channel protein type 1 subunit alpha
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 3 subunit alpha
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 9 subunit alpha
- Sodium channel protein type 2 subunit alpha
- Sodium channel protein type 8 subunit alpha
- Sodium channel protein type 4 subunit alpha
- Sodium channel protein type 7 subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003008 (system process), GO:0050877 (nervous system process), GO:0048731 (system development), GO:0006810 (transport), GO:0007399 (nervous system development), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:0006812 (monoatomic cation transport), GO:0019233 (sensory perception of pain), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)