Protein: Histone deacetylase 8 (EC 3.5.1.98) (Q94EJ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subcellular location: Nucleus {ECO:0000269|PubMed:22363501}. Cytoplasm {ECO:0000269|PubMed:22363501}.
Sequence: MVTNRVDVFWHEGMLRHDAVEGVFDTGYDPGFLDVLEKHPENADRVRNMLSILRRGPIAPHVNWFTGLPAIVSELLMFHTSEYIEKLVEADKSGERCEIAAGTFMSPGSWEAALLAAGTTLSAMQHILDCHGKIAYALVRPPGHHSQPTQADGYCFLNNAALAVKLALNSGSCSRVAVIDIDVHYGNGTAEGFYTSDKVLTVSLHMNHGSWGSSHPQKGSIDELGEDVGLGYNLNVPLPNGTGDRGYEYAMNELVVPAVRRFGPDMVVLVVGQDSSAFDPNGRQSLTMNGYRRIGQIMRGVAEEHSHGRLLMVQEGGYHVTYAAYCLHAMLEGVLKIPEPHLSDPIAYYPEEEANAVAAVESIKTYHTEFVPFLRGT
InterPro domains: - IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [3-374]
- IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [5-371]
- IPR023801: Histone deacetylase domain (domain) [39-332]
- IPR000286: Histone deacetylase HDAC (family) [141-274]
Interaction partners: - Histone deacetylase 17
- Putative histone deacetylase 10
- AT-rich interactive domain-containing protein 1
- NAD-dependent protein deacetylase SRT1
- NAD-dependent protein deacylase SRT2
- Histone-lysine N-methyltransferase SUVR3
- High mobility group B protein 9
- High mobility group B protein 10
- High mobility group B protein 15
- Putative high mobility group B protein 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0050793 (regulation of developmental process), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0009653 (anatomical structure morphogenesis), GO:0099402 (plant organ development), GO:0045595 (regulation of cell differentiation), GO:0045682 (regulation of epidermis development), GO:2000026 (regulation of multicellular organismal development), GO:1905392 (plant organ morphogenesis), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0090558 (plant epidermis development), GO:0048364 (root development), GO:0090627 (plant epidermal cell differentiation), GO:0010015 (root morphogenesis), GO:0030856 (regulation of epithelial cell differentiation), GO:0045604 (regulation of epidermal cell differentiation), GO:0022622 (root system development), GO:0010053 (root epidermal cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)