Protein: U6 snRNA-associated Sm-like protein LSm3 (P62310)
Organism: Homo sapiens (Human)
Function: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
Sequence: MADDVDQQQTTNTVEEPLDLIRLSLDERIYVKMRNDRELRGRLHAYDQHLNMILGDVEETVTTIEIDEETYEEIYKSTKRNIPMLFVRGDGVVLVAPPLRVG
InterPro domains: - IPR040002: U6 snRNA-associated Sm-like protein Lsm3 (family) [8-100]
- IPR034105: Sm-like protein Lsm3 (domain) [16-97]
- IPR047575: Sm domain (domain) [16-101]
- IPR010920: LSM domain superfamily (homologous_superfamily) [16-97]
- IPR001163: Sm domain, eukaryotic/archaea-type (domain) [19-97]
Interaction partners: - Small nuclear ribonucleoprotein Sm D1
- Small nuclear ribonucleoprotein Sm D2
- U6 snRNA-associated Sm-like protein LSm8
- U6 snRNA-associated Sm-like protein LSm2
- U6 snRNA-associated Sm-like protein LSm5
- U6 snRNA-associated Sm-like protein LSm4
- U6 snRNA-associated Sm-like protein LSm1
- U6 snRNA-associated Sm-like protein LSm7
- U6 snRNA-associated Sm-like protein LSm6
- Small nuclear ribonucleoprotein G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0140694 (non-membrane-bounded organelle assembly), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0033962 (P-body assembly), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0120114 (Sm-like protein family complex), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0005654 (nucleoplasm), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0034719 (SMN-Sm protein complex), GO:0005681 (spliceosomal complex), GO:0043233 (organelle lumen), GO:0030532 (small nuclear ribonucleoprotein complex), GO:0071013 (catalytic step 2 spliceosome), GO:0043227 (membrane-bounded organelle), GO:0097525 (spliceosomal snRNP complex), GO:0005689 (U12-type spliceosomal complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005684 (U2-type spliceosomal complex), GO:0070013 (intracellular organelle lumen), GO:0071007 (U2-type catalytic step 2 spliceosome), GO:0071011 (precatalytic spliceosome), GO:0097526 (spliceosomal tri-snRNP complex), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005685 (U1 snRNP), GO:0071005 (U2-type precatalytic spliceosome), GO:0046540 (U4/U6 x U5 tri-snRNP complex)