Protein: AP-3 complex subunit delta (Adaptor-related protein complex 3 subunit delta) (Delta-adaptin 3) (Delta-adaptin) (Q9UTL8)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).
Subcellular location: Golgi apparatus {ECO:0000250|UniProtKB:Q08951}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q08951}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q08951}; Cytoplasmic side {ECO:0000250|UniProtKB:Q08951}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250|UniProtKB:Q08951}.
Sequence: MVFERTLIDLIKGIRSHANDEEAFIATCLLECRKEATSQDADLKSEAILKLAYLEMLGVDISWASFQIVEVMSSSKILQKQKGYLAAVQSFKPDTDVLMLTTNLLKKDLMSSKVPEITLAIDGLSHFSTLGLARDLYRDVLILLNHSVPYVRKRTILLLYRLCLQYPEAISACIPKLRERLDDPDTSVVNAAVSVICELARRAPKNYLEFAPDLFHLLTTSSNNWMLIKLIKLFASLTPYEPRLVKKLIPSLTDIIENTHAMSLLYECINTIVSGNMLVGHSQCDKLASLCASKLRGFFEDTDQNLKYIALLCLRKLANTHPSLVSAQLDIILKCLVDTDTSIRLRALDLVNEIVNKENIRTIVKTLMLQLIVSSDESAVEDIRNSTATRIIEMTSKSTYMNIADFEWLLTVYVDLANIPGIDTGTLLNNQIIDLCVRVKALRPFSVDIFSQAILDPSYVSTTDCSVSEKRTDILPAIIWCLGEYAEFIEEYLDILDALTRPSFKKCSNLAHRLLLQAITKIFCQWCLEEEPTWGVEKFGLVKLWVEKIVSFIEQFLNFQDMEIQRRASEFYILFNQVSDIVNTSDTMEVLELQKKPPYIVQNTMYKLFFGEPLNPVAVKAQRKVMPDENLDLNCPINGVIEVPKELLENIIQSDDSLINFDTEVPSSGIDTFSKKQFNSLESVPVQRDLSSPFYLSSNQHTTTTNSEPENLNVETSMSDEAFNADKVTKVTKNKRRRKIFTSPSLQAMVVAQDEVPEGISLADIENKENPSNSNVYSLISLDPPLSTNQGSMGDIVLETKSPIRVEKKKSKKKKKKKEKTSGKE
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [20-575]
- IPR017105: Adaptor protein complex AP-3, delta subunit (family) [1-825]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1-590]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [22-577]
Interaction partners: - AP-3 complex subunit beta
- AP-3 complex subunit mu
- AP-3 complex subunit sigma
- AP-2 complex subunit mu
- AP-2 complex subunit sigma
- AP-1 complex subunit sigma-1
- AP-2 complex subunit beta
- AP-1 complex subunit beta-1
- AP-1 complex subunit mu-1
- AP-2 complex subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding), GO:0030276 (clathrin binding), GO:0140312 (cargo adaptor activity), GO:0035615 (clathrin adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0006903 (vesicle targeting), GO:0051640 (organelle localization), GO:0033036 (macromolecule localization), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0051648 (vesicle localization), GO:0045184 (establishment of protein localization), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0016197 (endosomal transport), GO:0015031 (protein transport), GO:0016482 (cytosolic transport), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0051650 (establishment of vesicle localization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0048475 (coated membrane), GO:0030119 (AP-type membrane coat adaptor complex), GO:0030133 (transport vesicle), GO:0005794 (Golgi apparatus), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0030118 (clathrin coat), GO:0030140 (trans-Golgi network transport vesicle), GO:0098588 (bounding membrane of organelle), GO:0030131 (clathrin adaptor complex), GO:0012506 (vesicle membrane), GO:0005798 (Golgi-associated vesicle), GO:0030130 (clathrin coat of trans-Golgi network vesicle), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0030125 (clathrin vesicle coat), GO:0012510 (trans-Golgi network transport vesicle membrane), GO:0030136 (clathrin-coated vesicle), GO:0030121 (AP-1 adaptor complex), GO:0030662 (coated vesicle membrane), GO:0030660 (Golgi-associated vesicle membrane), GO:0030665 (clathrin-coated vesicle membrane)