Protein: Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) (P43119)
Organism: Homo sapiens (Human)
Function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
InterPro domains: - IPR008365: Prostanoid receptor (family) [20-318]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [30-292]
- IPR000370: Prostacyclin (prostanoid IP) receptor (family) [4-385]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [30-291]
Interaction partners: - Guanine nucleotide-binding protein G
- Prostacyclin synthase
- Thromboxane A2 receptor
- Prostaglandin G/H synthase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0004953 (icosanoid receptor activity), GO:0004954 (prostanoid receptor activity), GO:0004955 (prostaglandin receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0043207 (response to external biotic stimulus), GO:0035556 (intracellular signal transduction), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0008284 (positive regulation of cell population proliferation), GO:0032496 (response to lipopolysaccharide), GO:0006954 (inflammatory response), GO:0033993 (response to lipid), GO:0002237 (response to molecule of bacterial origin), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0019932 (second-messenger-mediated signaling), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0019722 (calcium-mediated signaling), GO:0019934 (cGMP-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0070820 (tertiary granule), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0070821 (tertiary granule membrane), GO:0035579 (specific granule membrane)