wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Major facilitator superfamily (MFS) profile domain-containing protein (A0A1D8PJQ4)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MDSKKASFESNHKELSASSSNEFNEVLEFTVSNYETLQQQKELGSRRSSVHRKSLEAIKKCITGESNYESPETKDYSVHHIYGDLDSDAIEIQRTQTRNLILTKLESRVEDNTNNYSNDNHEHEVECQDTISVIPDTNIEIAQHGKEFDTIDPELITWNGPDDTEDPRNWPINKKIFLLGFVSLYALVAPMSSSMLSPAMTFIAEDFHISSPIIKSMVVSIQILAWAFGPLIIAPLSEHDYIGRKLVLDVSCWMSLFFNLGCAFSQTTAQMMVCRFIGGLFGCVPMNVCAGVISDMFDAQSRNAALAGYSLVPLLGPVIAPVISGFIVDHKQWRWTFYVLCIFNGFVAITATFLFKETYSPTLLKRKAKKLREQTGNVNLHTIYEIADGETKLGKIWLCMVRPIKLLFTHPMIVGLGSFMAFTYGFMYLMIVTFPEIFGNQYGYSKSVTGLMYIPMGIGFIIGVIFWTYMVGNVYERLTSRNNGVAKPEFRLPCLIASSIFIPVGLIWFGWSAQKKLHWIMPGIGSAIFAMGLVCVFQTIQNYLIDMNVRYAASSVAAAALFRSLFGFSFPLFANKMYSALGYGWANTMCAFIGIFLGVPFPIFCYMYGEKIRHWADKRIEKEQSKRDQKNLERLKLKNDSVV
InterPro domains: - IPR011701: Major facilitator superfamily (family) [184-571]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [157-618]
- IPR020846: Major facilitator superfamily domain (domain) [178-613]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0042910 (xenobiotic transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015695 (organic cation transport), GO:0015846 (polyamine transport), GO:0015848 (spermidine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ganglioside-induced differentiation-associated protein 2 (Q9DBL2)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MDPLGAPSQFVDVDTLLSWGDSYEDEVDCADSTAEAFQEDASRSPFVYSRDVNGKVVLWKGDVALLNCTAIVNTSNESLTDKNPVSESIFMLAGPDLKEDLQKLKGCRTGEAKLTKGFNLAARFIIHTVGPKYKSRYRTAAESSLYSCYRNVLQLAKEQSMSSVGFCVINSAKRGYPLEDATHIALRTVRRFLEIHGENIEKVVFAVSELEEATYQKLLPLYFPRSLKEEIRSLPYLPADIGNAEGEPVVPERQIRISEKPGASEDNEEEDEDEGLGVDLSFIGSHAFARMEGDIDKQRKLILQGQLSEAALQKQHQRNYNRWLCQARSEDLSDIASLKALYQTGVDNCGRTVMVVVGRNIPVTLIDMDKALLYFIHVMDHIAVKEYVLVYFHTLTSDYNHLDSDFLKKLYDVVDIKYKRNLKAVYFVHPTFRSKVSTWFFTTFSVSGLKDKIHHVDSLQQLFSAISPEQIDFPPFVLEYDARENGPYFASYPPSPDL
InterPro domains: - IPR001251: CRAL-TRIO lipid binding domain (domain) [330-482]
- IPR043472: Macro domain-like (homologous_superfamily) [1-252]
- IPR002589: Macro domain (domain) [43-223]
- IPR035793: GDAP2, macro domain (domain) [55-222]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [330-485]
Interaction partners: - Core histone macro-H2A.2
- WD repeat-containing protein 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0007264 (small GTPase mediated signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: serine C-palmitoyltransferase (EC 2.3.1.50) (Q8ILT9)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MHLKGLMDYNYFLGLEVLQNFDIVNYLIAGIVLLALILAVFNEDASAGSPRLSWVLGEFLPIQHSIFALNSNVEKKLFRKRSSKIYTFITCLYNLFVELRNSITEGNFIMLVKGWFLKVLNKIILYKNLLLLKYRSQSKRHLFYMLVKKKYNLPIQKEENEMQSYLDAKRELIRLNRWSFMWRVSNVKNEFLLCEKRKARPISSYSYLDFIREPLVQNNAIQAAMEWSTGNHGPRMLGGNSQILRDLEKVVGNFFGRNDSILAVCGFLACMSGIVAVATHEDIILYDSRTHACVKMGIQICGAKAYSFKHNDYNHLEVLLIKYRYKYRNCWVCIESVYSMDGDIPHLPTFKKLCIQHKAKLYVDEAHGLGVLGKTGRGIEEHFNMPGTADIIVGTFSKSIGGVGGYIVASDEVIEFLDFHCIGNVFSAPLPAYCAGGALKAFELIDTQPWRIQKLKFNTKYLRNGLKTGMGHWPKDYPESYKYIIEGDDATSVIPVIFPNDPDRLFKICNLLLKMNWMISAVVYPACPLKYPRFRVTATSAYTIEYMNEFISDIVRATVRVKPSPLDTQLII
InterPro domains: - IPR001917: Aminotransferase, class-II, pyridoxal-phosphate binding site (binding_site) [395-404]
- IPR015421: Pyridoxal phosphate-dependent transferase, major domain (homologous_superfamily) [213-448]
- IPR050087: 8-amino-7-oxononanoate synthase class-II (family) [182-555]
- IPR004839: Aminotransferase, class I/classII, large domain (domain) [216-552]
- IPR015424: Pyridoxal phosphate-dependent transferase (homologous_superfamily) [169-557]
- IPR015422: Pyridoxal phosphate-dependent transferase, small domain (homologous_superfamily) [194-551]
Interaction partners: - NAD
- GDP-L-fucose synthase
- Delta-aminolevulinic acid dehydratase
- indole-3-glycerol-phosphate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016408 (C-acyltransferase activity), GO:0016409 (palmitoyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Myeloid leukemia factor 1 (Myelodysplasia-myeloid leukemia factor 1) (P58340)
Organism: Homo sapiens (Human)
Function: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9QWV4}. Nucleus {ECO:0000250|UniProtKB:Q9QWV4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9QWV4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9QWV4}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9QWV4}.
Sequence: MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGSSVKSNKK
InterPro domains: - IPR019376: Myeloid leukemia factor (family) [5-240]
Interaction partners: - 14-3-3 protein epsilon
- Centromere protein U
- Nucleophosmin
- DnaJ homolog subfamily B member 6
- Nuclear receptor-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0032990 (cell part morphogenesis), GO:0070584 (mitochondrion morphogenesis), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: At4g01560 (Ribosomal RNA processing Brix domain protein) (Q9M125)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MGFKRKKDDGDGEEMESDVRGKSTFSGGEKRNVILPSMIKNKDKRSKVYAKQKHEKKLEKQKKIRARDAAEKRALELGEEPPQKMIPKTIENTRESDETVCRPDDEELFADIDADEFNPVLRREIAPKVLLTTCRFNSTRGPALISELLSVIPNSHYQKRGTYDLKKIVEYATKKDFTSLIVVHTNRREPDALLIIGLPNGPTAHFKLSNLVLRKDIKNHGNPTSHQPELVLNNFTTRLGNRVGRFFQSLFPPDPNFRGRRVVTFHNQRDFIFFRHHRYIFETKESKSDKGKEETIKPRLQECGPRFTLKLVTLQHGTFDTKGGEFEWVHKPEMDTSRRRFFL
InterPro domains: - IPR007109: Brix domain (domain) [127-320]
- IPR044281: U3 snoRNP protein/Ribosome production factor 1 (family) [35-343]
Interaction partners: - AT5g04600/T32M21_200
- 60S ribosome subunit biogenesis protein NIP7 homolog
- AT5g20600/F7C8_190
- Probable rRNA-processing protein EBP2 homolog
- Transducin/WD40 repeat-like superfamily protein
- Protein MAK16 homolog
- Ribosome assembly factor mrt4
- Pescadillo homolog
- Ribosome biogenesis protein WDR12 homolog
- Ribosome biogenesis protein BOP1 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0019843 (rRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0042254 (ribosome biogenesis), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0006364 (rRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: EGF like, fibronectin type III and laminin G domains (D6RJD2)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTN
InterPro domains: - IPR001791: Laminin G domain (domain) [1-112]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [1-106]
- IPR050372: Neurexin-related cell adhesion and synaptic protein (family) [1-111]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006259 (DNA metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process), GO:0009101 (glycoprotein biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) (P23280)
Organism: Homo sapiens (Human)
Function: Reversible hydration of carbon dioxide. Its role in saliva is unknown.
Subcellular location: Secreted.
Sequence: MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEILDYLRRALN
InterPro domains: - IPR036398: Alpha carbonic anhydrase domain superfamily (homologous_superfamily) [20-280]
- IPR018338: Carbonic anhydrase, alpha-class, conserved site (conserved_site) [124-140]
- IPR001148: Alpha carbonic anhydrase domain (domain) [21-278]
- IPR023561: Carbonic anhydrase, alpha-class (family) [21-273]
Interaction partners: - Carbohydrate sulfotransferase 8
- Solute carrier family 2, facilitated glucose transporter member 5
- Carbohydrate sulfotransferase 9
- 1,25-dihydroxyvitamin D
- BPI fold-containing family A member 2
- Alpha-enolase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016829 (lyase activity), GO:0016835 (carbon-oxygen lyase activity), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0016836 (hydro-lyase activity), GO:0004089 (carbonate dehydratase activity), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0055085 (transmembrane transport), GO:0003008 (system process), GO:0048878 (chemical homeostasis), GO:0006885 (regulation of pH), GO:0050801 (monoatomic ion homeostasis), GO:0050877 (nervous system process), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:1901135 (carbohydrate derivative metabolic process), GO:0031348 (negative regulation of defense response), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:0035725 (sodium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0019233 (sensory perception of pain), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Baculoviral IAP repeat-containing 2 (Q6P6S1)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MENSTVLSNWTKENKEKMKYDFSCELYRMSTYSAFPRGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKQGDSPTEKHRQFYPSCSFVQTLLSGGLQSAAKNTSPAKSRFAHSLPLEQGGIHSSLPSNPLNSRAVEDFSLRMNPCSYAMSTEEARFLSYSMWPLSFLSPAELAKAGFYYTGPGDRVACFACGGKLSNWEPNDDPLSEHRRHFPHCPFLENTSETQRFSVSNLSMQTHSARMRTFLYWPSSVLVQPEQLASAGFYYVDHNDDVKCFCCDGGLRCWEPGDDPWIEHAKWFPRCEFLIRMKGQEFVDEIQARYPHLLEQLLSTSDTSEEENADPPVVHLGPGENWEDAVMMNTPVVKAALDMGFSRSLVRQTVQRQILATGENYRTVSDIVSALLNAEDERREEEKERQSEETASGDLSLIRKNRMALFQQLTCVIPILDDLLEASVLTKEEHDIIRQKTQIPLQARELIDTILVKGNAAASVFKNSLKEVDSTLYEHLFVEKTMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDREVSIVFIPCGHLVVCRECAPSLRKCPICRGTIKGTVRTFLS
InterPro domains: - IPR041933: BIRC2/BIRC3, UBA domain (domain) [362-408]
- IPR001370: BIR repeat (repeat) [23-310]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [423-550]
- IPR001315: CARD domain (domain) [424-514]
- IPR048875: BIRC2/3-like, UBA domain (domain) [359-411]
- IPR050784: Inhibitor of Apoptosis (family) [23-589]
- IPR001841: Zinc finger, RING-type (domain) [542-577]
Interaction partners: - TNF receptor-associated factor
- Receptor-interacting serine/threonine-protein kinase 1
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Mitogen-activated protein kinase kinase kinase 7
- TNF receptor-associated factor
- Caspase-9
- Diablo IAP-binding mitochondrial protein
- Diablo IAP-binding mitochondrial protein
- RING-type E3 ubiquitin transferase
- Toll-like receptor 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)
Protein: STEAP1 protein (Six-transmembrane epithelial antigen of prostate 1) (Q9CWR7)
Organism: Mus musculus (Mouse)
Function: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
Subcellular location: Endosome membrane {ECO:0000269|PubMed:16609065}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16609065}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MEISDDVTNPEQLWKMKPKGNLEDDSYSTKDSGETSMLKRPGLSHLQHAVHVDAFDCPSELQHTQEFFPNWRLPVKVAAIISSLTFLYTLLREIIYPLVTSREQYFYKIPILVINKVLPMVAITLLALVYLPGELAAVVQLRNGTKYKKFPPWLDRWMLARKQFGLLSFFFAVLHAVYSLSYPMRRSYRYKLLNWAYKQVQQNKEDAWVEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSDSLTWREFHYIQSKLGIVSLLLGTVHALVFAWNKWVDVSQFVWYMPPTFMIAVFLPTLVLICKIALCLPCLRKKILKIRCGWEDVSKINRTEMASRL
InterPro domains: - IPR013130: Ferric reductase transmembrane component-like domain (domain) [120-257]
- IPR051267: STEAP family metalloreductases (family) [15-335]
Interaction partners: - Metalloreductase STEAP2
- Prostate stem cell antigen
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016722 (oxidoreductase activity, acting on metal ions), GO:0000293 (ferric-chelate reductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)