Protein: Flowering time control protein FPA (Q8LPQ9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays a role in the regulation of flowering time in the autonomous flowering pathway by decreasing FLOWERING LOCUS C mRNA levels. Required for RNA-mediated chromatin silencing of a range of loci in the genome. Cotranscriptionally recognizes aberrant RNA and marks it for silencing. Controls alternative cleavage and polyadenylation on pre-mRNAs and antisense RNAs. Acts redundantly with FCA to prevent the expression of distally polyadenylated antisense RNAs at the FLC locus.
Subcellular location: Nucleus {ECO:0000269|PubMed:17916737}.
Sequence: MALSMKPFRADDSGFQSNNLWVGSLTPETTESDLTELFGRYGDIDRITVYSSRGFAFIYYRHVEEAVAAKEALQGANLNGSQIKIEYARPAKPCKSLWVGGIGPNVSKDDLEEEFSKFGKIEDFRFLRERKTAFIDYYEMDDALQAKSMNGKPMGGSFLRVDFLRSQAPKKEQWAGSYDNRNGNMNHKPQYPHSYEDFKGDVQPSKVLWIGFPPTATQCNDEQILHNAMILFGEIERVKSYPSRNFALVEFRSAEEARQCKEGLQGRLFNNPRIKIMYSNDELPPEQDDTSFYSGMKRSRTDMFNNDPSFVSSPHSTGIPGSMRPLRGTNERSYNGAEYNDVVGKEPNWRRPSANGTGILPSPTGPGILPSPAQGTRRPMRSNPDSWEGYDPAQLVRESKRTRRDGSVDGFTPMGVDERSFGRGSVAARPIRGPPDSDHIWRGMIAKGGTPVCCARCVPMGKGIETKLPEVVNCSARTDLNMLAKHYAVAIGCEIVFFVPDREEDFASYTEFLRYLSSKDRAGVAKLDDGTTLFLVPPSDFLTDVLQVTRQERLYGVVLKLPPPAVPVTASYRQESQSNPLHYMDQARDSPANASHSLYPPRENYIRGAPEHLTAASKPSVSEPLRIPNNAAPQAGVSLTPELLATLASILPATSQPAAPESHQPMSGPSTVVSTAHQSNGLYNGEAPSQAWKRGPQTVHDASNQSFQQYGNQYTPAGQLPPPPSRYPPASNNPNYTSGMVHGNMQYQSQSVNMPQLSPLPNMPHNNYSMYTQGSSNHPVSQPMVQQYQPEASMPNQNYGPIPSYQQANFHGVTTNQAQNLNPSQFQAAMQPPADKANLEPQNQALRLQPMISGDGQGTTDGEVDKNQRYQSTLQFAANLLLQIQQKQQQQSSGTPAGQGP
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [12-281]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [8-296]
- IPR012921: Spen paralogue and orthologue SPOC, C-terminal (domain) [434-560]
- IPR000504: RNA recognition motif domain (domain) [18-281]
Interaction partners: - WD-40 repeat-containing protein MSI4
- Flowering locus K homology domain
- Protein FLOWERING LOCUS D
- 30-kDa cleavage and polyadenylation specificity factor 30
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
- 25S rRNA
- Polyketide cyclase/dehydrase and lipid transport superfamily protein
- At1g29530
- Inactive protein FRIGIDA
- Secreted protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:2000241 (regulation of reproductive process), GO:2000242 (negative regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0048583 (regulation of response to stimulus), GO:0051301 (cell division), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0048579 (negative regulation of long-day photoperiodism, flowering), GO:0048580 (regulation of post-embryonic development), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0002832 (negative regulation of response to biotic stimulus), GO:0043170 (macromolecule metabolic process), GO:0009909 (regulation of flower development), GO:0098542 (defense response to other organism), GO:0031347 (regulation of defense response), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0016441 (post-transcriptional gene silencing), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0010608 (post-transcriptional regulation of gene expression), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0035194 (RNA-mediated post-transcriptional gene silencing), GO:0030422 (siRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)