Protein: Occludin (Q6P6T5)
Organism: Rattus norvegicus (Rat)
Function: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q16625}; Multi-pass membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q16625}.
Sequence: MSVRPFESPPPYRPDEFKPNHYAPSNDMYGGEMHVRPMLSQPAYSFYPEDEILHFYKWTSPPGVIRILSMLVIVMCIAVFACVASTLAWDRAYGTGIFGGSMNYPYGSGFGSYGGGFGGYGYGYGYGYGGYTDPRAAKGFLLAMAAFCFIASLVIFVTSVIRSGMSRTRRYYLIVIIVSAILGIMVFIATIVYIMGVNPTAQASGSMYGSQIYTICSQFYTPGGTGLYVDQYLYHYCVVDPQEAIAIVLGFMIIVAFALIIVFAVKTRRKMDRYDKSNILWDKEHIYDEQPPNVEEWVKNVSAGTQDMPPPPSDYAERVDSPMAYSSNGKVNGKRSYPDSLYKSPPLVPEVAQEIPLTLSVDDFRQPRYSSNDNLETPSKRTPTKGKAGKAKRTDPDHYETDYTTGGESCDELEEDWLREYPPITSDQQRQLYKRNFDAGLQEYKSLLAELDEVNKELSRLDRELDDYREESEEYMAAADEYNRLKQVKGSADYKSKKNYCKQLKSKLSHIKRMVGDYDRRKT
InterPro domains: - IPR008253: Marvel domain (domain) [57-269]
- IPR031176: ELL/occludin family (family) [19-521]
- IPR010844: Occludin homology domain (domain) [415-523]
- IPR002958: Occludin (family) [1-523]
Interaction partners: - Claudin-1
- Tight junction protein ZO-1
- Tight junction protein 2
- Junctional adhesion molecule A
- Claudin-5
- Claudin-3
- Endothelial cell-selective adhesion molecule
- Claudin
- Cadherin-1
- Claudin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0071840 (cellular component organization or biogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0034762 (regulation of transmembrane transport), GO:0060255 (regulation of macromolecule metabolic process), GO:0034764 (positive regulation of transmembrane transport), GO:0031324 (negative regulation of cellular metabolic process), GO:0003013 (circulatory system process), GO:0060249 (anatomical structure homeostasis), GO:0043114 (regulation of vascular permeability), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0010827 (regulation of glucose transmembrane transport), GO:0003018 (vascular process in circulatory system), GO:0008015 (blood circulation), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0043117 (positive regulation of vascular permeability), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0035633 (maintenance of blood-brain barrier), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0010828 (positive regulation of glucose transmembrane transport), GO:0043933 (protein-containing complex organization), GO:0034330 (cell junction organization), GO:0010629 (negative regulation of gene expression), GO:0051174 (regulation of phosphorus metabolic process), GO:0031399 (regulation of protein modification process), GO:0065003 (protein-containing complex assembly), GO:0031400 (negative regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0034329 (cell junction assembly), GO:0046324 (regulation of glucose import), GO:0046326 (positive regulation of glucose import), GO:0045936 (negative regulation of phosphate metabolic process), GO:0045216 (cell-cell junction organization), GO:0042325 (regulation of phosphorylation), GO:0007043 (cell-cell junction assembly), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0120193 (tight junction organization), GO:0043297 (apical junction assembly), GO:0120192 (tight junction assembly), GO:0070830 (bicellular tight junction assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0070161 (anchoring junction), GO:0005911 (cell-cell junction), GO:0043296 (apical junction complex), GO:0070160 (tight junction), GO:0005923 (bicellular tight junction)