Protein: Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase I delta) (CaM-KI delta) (CaMKI delta) (CaM kinase ID) (CaMKI-like protein kinase) (CKLiK) (mCKLiK) (Q8BW96)
Organism: Mus musculus (Mouse)
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta (By similarity). Isoform 1 but not isoform 2 activates CREB1.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Nuclear upon activation. {ECO:0000250}.
Sequence: MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNASVSSNLSLASQKDCLAPSTLCSFLSSSSGVAGVGAERRPRPTTVTTGHTGSK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [16-307]
- IPR017441: Protein kinase, ATP binding site (binding_site) [29-57]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [140-152]
- IPR000719: Protein kinase domain (domain) [23-279]
Interaction partners: - Neuronal migration protein doublecortin
- Translation initiation factor eIF2 assembly protein
- Juxtaposed with another zinc finger protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0032409 (regulation of transporter activity), GO:0019538 (protein metabolic process), GO:0034762 (regulation of transmembrane transport), GO:0060255 (regulation of macromolecule metabolic process), GO:0034764 (positive regulation of transmembrane transport), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0007626 (locomotory behavior), GO:0031325 (positive regulation of cellular metabolic process), GO:0007611 (learning or memory), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0050890 (cognition), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0071702 (organic substance transport), GO:0006796 (phosphate-containing compound metabolic process), GO:0006811 (monoatomic ion transport), GO:0010468 (regulation of gene expression), GO:0019932 (second-messenger-mediated signaling), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0051247 (positive regulation of protein metabolic process), GO:0022898 (regulation of transmembrane transporter activity), GO:0008104 (protein localization), GO:0043269 (regulation of monoatomic ion transport), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0051279 (regulation of release of sequestered calcium ion into cytosol), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0006468 (protein phosphorylation), GO:0010959 (regulation of metal ion transport), GO:0018193 (peptidyl-amino acid modification), GO:0019722 (calcium-mediated signaling), GO:0019220 (regulation of phosphate metabolic process), GO:0016310 (phosphorylation), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0018108 (peptidyl-tyrosine phosphorylation), GO:2001257 (regulation of cation channel activity), GO:2000649 (regulation of sodium ion transmembrane transporter activity), GO:0045859 (regulation of protein kinase activity), GO:0030001 (metal ion transport), GO:0042327 (positive regulation of phosphorylation), GO:0018105 (peptidyl-serine phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0018209 (peptidyl-serine modification), GO:0046777 (protein autophosphorylation), GO:0018107 (peptidyl-threonine phosphorylation), GO:0018209 (peptidyl-serine modification), GO:0045860 (positive regulation of protein kinase activity), GO:0032147 (activation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0140535 (intracellular protein-containing complex), GO:0005886 (plasma membrane)