Protein: 26S proteasome regulatory subunit RPN1 (A0A1D8PFL7)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
Sequence: MAPSQEQSKEQIQSQTSKDQQPTKSDKSKVQKEEELSEEDQHLKDELELLVERLNEPNQDRALYNKYLDALKTFIKESTTSMTAVPKPLKFLRPHYPSLTELYTNWSNQFSAKDVIVIKLADILSVLATTYSDEGNRDSLKYRLLASDDTISDWGHEYMRHLALEIGESFQENLGVDEELVNKLVKLALQIVPFFLKHNAEADAVDLLLEIECIDKLPQFVDENTFARVCLYVTSCVPYLAPPDDVSFLNTAYSIYLSHNQLTQALTLAIKLDDNELIKQVFDSTTDESLHKQLGFILSQQNSNFKYPGENPEVQECISNVKLAEYFQYLVKELNLLDPKVPEDVYKSHLENSKFGLGTSGSIDSAKQNLAASFVNGFLNLGFGNDKLVQTEEDNKSWIYRTKGSGMASTTASLGSIHQWNINEGLQVLDKYTYSEDSEVKAGALLGTGVVSANVHDEVDAAFALLQEYVHEPNKLYQTAAINGLGIAFAGSANEDVLNLLLPLVSDLDISLEISCLAALALGHIFVGTCHGDVTSTILQTLLERDYTQLTNKFIKFMSLGLGLLYMGRTEQAEDVLETIDAIEHPISKTLKVLVNICAFAGTGNVLQIQALLQMCTAKPKDQLEEEKKLEQSEEEQQQQQQNKDTKSNGEGGEEEEDVEMEDAESKNETSENTTASATSTTSSSKEKGDSSSSAAAAAAGDEKAQEGGDDKEDEEEIDEEEELYQGIAVLGLACIAMGEDIGQDMSLRHFGHLMHYGNSLIRRAVPLAMGLVSTSNPQMKVFETLSRYSHDPDLEVAQNSIYSMGLVGAGTNNARLAQLLRQLASYYIKSPDTLFMVRIAQGILHLGKGTLTLTPYNSERTILSKVSLASLLTIAIALLDPRSFILNDSTTETTHQLLYYLTPAVKPRMLVTVDEELKPIKVNVRVGQAVDVVGQAGKPKTITGWVTQSTPVLLNYGERAELENTDEWISLSSSLEGVVILKKNPEYMEIDS
InterPro domains: - IPR040892: RPN1, N-terminal (domain) [47-351]
- IPR016024: Armadillo-type fold (homologous_superfamily) [39-849]
- IPR011989: Armadillo-like helical (homologous_superfamily) [358-880]
- IPR016643: 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit (family) [6-991]
- IPR041433: 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal (domain) [934-988]
- IPR002015: Proteasome/cyclosome repeat (repeat) [480-828]
Interaction partners: - Proteasome subunit alpha type
- Proteasome regulatory particle lid subunit
- Proteasome regulatory particle lid subunit
- 26S proteasome regulatory subunit 6B homolog
- Proteasome regulatory particle base subunit
- proteasome endopeptidase complex
- 26S proteasome regulatory subunit RPN8
- 26S proteasome regulatory subunit 8 homolog
- Proteasome regulatory particle base subunit
- Proteasome subunit alpha type
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0030447 (filamentous growth)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0022624 (proteasome accessory complex), GO:0005622 (intracellular anatomical structure), GO:1902494 (catalytic complex), GO:0008540 (proteasome regulatory particle, base subcomplex), GO:0005838 (proteasome regulatory particle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0000502 (proteasome complex), GO:1905368 (peptidase complex), GO:1905369 (endopeptidase complex)