Protein: MFS antiporter QDR3 (Q59XM0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=In contrast to QDR1 and QDR2, does not accumulate in membrane rafts and shows uniform distribution at the cell membrane
Sequence: MSHSPNLSPQISNDIIDADTTSLASTETQQNIQHSQIHPIGHHGREQSEEPQNTTKTTTTTTNKIHTTTPSVDPDLGPLRELEQDLSSLESQQEQYLSQKPTSTSIKTNKVPLRERRGLLAQIVLIPEYEDARDYPNKIKYLIVFIIAFASLAGPFGTSVMLPAIDDIVNDLNTNVSTVNVSVGIYLLSLGIFPLWWSSFSERFGRRSVYMVSFTLFVAFSIGTALSPNIAALIVLRVLQGGSSASVQAVGAGTIADLFIPQERGQAMGLYYLGPLAGPFLAPILGGAVSQAWGWRATQWLLMIISACSFVLITFFLPETLRRVDTIQVAKDLMKKSDNNGSQNEKIHDDFAGADNSSVHDIDGNPIPGTELHQVVSNLSRRSSNARSIVTYMEEQENEGPIIDPVMPSISRLTTNRSAYSQRIHQNYVTDELRKTTSNLTQSNHSQYNNNNNNDNDKWSSVKTNCYDLIIRPLHSIILLKHPPVVLVISFSAISFAAIYFFNMAISYEYARSPYNFSSVILGLMYIPNSVTYFMASIIGGKWNDRLLNRYAQKHGELVPESRLSWNIVVAIILYPMACLIFGWTIKYREFWVIPLIGTALFGFASMLVIGATVTYLVDSLPGKGATGVALNNLIRQILAAIATFIVEPLLRAIGAGVLFSIIAGILLVSSLVLLYLKKRGAFFREHYDVMDLYAKL
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [133-680]
- IPR011701: Major facilitator superfamily (family) [148-643]
- IPR020846: Major facilitator superfamily domain (domain) [143-682]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015203 (polyamine transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0019953 (sexual reproduction), GO:0048878 (chemical homeostasis), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0019725 (cellular homeostasis), GO:0043934 (sporulation), GO:0009653 (anatomical structure morphogenesis), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0022413 (reproductive process in single-celled organism), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0055082 (intracellular chemical homeostasis), GO:0055088 (lipid homeostasis), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0030435 (sporulation resulting in formation of a cellular spore), GO:0009636 (response to toxic substance), GO:0030435 (sporulation resulting in formation of a cellular spore), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0034293 (sexual sporulation), GO:0043935 (sexual sporulation resulting in formation of a cellular spore), GO:0044091 (membrane biogenesis), GO:0022607 (cellular component assembly), GO:0061024 (membrane organization), GO:0071709 (membrane assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)