Protein: Phenoloxidase-activating factor 2 (A0A139W9S1)
Organism: Tribolium castaneum (Red flour beetle)
Subcellular location: Secreted
Sequence: MALLTLSLIILSIGSCLSANCICVPFWKCNDENFSTEDLDLVGFRSGCESYFDVCCTIKCGLRKSEIVIFEGTIRNRILGPENSANFGEFPWMLGVLSGRTYRCGASLIHPKVALTAAHCVHSNGFYKVRAGEWDWNSRKEPLKHQDRLAKKIIIHPGYDPNSLINDIALIILDRDFQLSENVGVVCLPPHNSEPLQEECVVSGWGKTHKSGKHQTVLNKAVFPIVPNSRCETALQRAHLGPLFRLHSSFMCAGGKEKDTCKGDGGSPLVCGVQGEEERYEQFGIVSWGLVCGTTDSPGVYVSVAQFVAWIDQQVLNENLDNQIYKY
InterPro domains: - IPR009003: Peptidase S1, PA clan (homologous_superfamily) [53-315]
- IPR001254: Serine proteases, trypsin domain (domain) [77-316]
- IPR051487: Serine/Threonine Proteases with Immune and Developmental Roles (family) [15-315]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [115-120]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [71-316]
- IPR001314: Peptidase S1A, chymotrypsin family (family) [105-270]
- IPR041515: PPAF-2-like, Clip domain (domain) [16-56]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0002684 (positive regulation of immune system process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002759 (regulation of antimicrobial humoral response), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium), GO:0002922 (positive regulation of humoral immune response), GO:0002760 (positive regulation of antimicrobial humoral response), GO:0010628 (positive regulation of gene expression), GO:0002920 (regulation of humoral immune response), GO:0002225 (positive regulation of antimicrobial peptide production), GO:0010468 (regulation of gene expression), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)