Protein: Nipped-B-like protein B (F1QBY1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity)
Subcellular location: Nucleus
Sequence: MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLYNGRIAEEVSCLLSRRDDALVSQLAHSLNQVSTEHIELKDNLGSDDPEGDVPLLLQTVLSRNPNVFREKSLMQQPMIPSYKMPQNSMHGSPASNYQQTTITPSPPSRYVQTQAGSGSRYMPQQNSPVPSPYAPQSPAGYMQYSHPPSYPQHQPIQQVSVSSPIVPSGMRNIHDNKVSGQVSGNSNHNARHCSSDEYINIVQRLGNDEGDPAMRNTSFPVRSACSPAGSEGTPKVGPRPPLILQSPPPYTSPSDTAPDLLLDSPERKKKQKRLLKEEGGKGAMYGIVSSPSKDSTKLTIKLSRVKSSETEQSAEPVVPVVDHGSDAENEVSCNSLSYHRNPQERLSAGQCLSGEQSAYQQVPVLQNIGALAAKQPGVVSGTPYDEAELDALAEIERIERESAIERERCSKEVQDKDKPLKKRKQDSYPQEPGAAGTAGASGTPGVGGGCNAGNKLVPQEACAASNGSSRPALMVSIDLQQAGRVEGPVDSCPVPATEAQRWTEDGSESTGVLRLKSKTDGEVQRTVDGRPEVIKQRVETTPQKTAVDGRPETPINKHENRREISNKVSSEKRSDLSKHRHDGKAEKIRAEGKGHETSRKHEGRSELSRDCKEERHREKDSDSSKGRRSDTSKSSRVEHNRDKEQEQEKVGDKGLEKGREKELEKGRDKERVKDQEKDQEKGRDKEVEKGRYKERVKDRVKEQEKVRDKEQVKGRDKKRSKDLEKCREKDQDKELEKDREKNQDKELEKGREKDQDKELEKGREKDRDKEMEKAREKDQDKELEKGREKDQDKELEKGQEKDRDKVREKDRDKVRDKDRDKVREKDRDKVREKDRDKLREKDREKIRERDRDKGREKDRDKEQVKTREKDQEKERLKDRDKEREKVRDKGRDRDRDQEKKRNKELTEDKQAPEQRSRPNSPRVKQEPRNGEESKIKPERSVHKNSNNKDEKRGGENKNQLDGHKPQSIDSKTADFPNYLLGGKSSALKNFVIPKLKRDKEGNVMQEVRIELFSEPRVKLEKLDLVEDLNKGAKPVVVLKKLSIDEVQKMISNSRSSKSSRSSHGRFRETDSRLPLCERVKMNKRRRSSTNEKPKYAEVSSDDDSSSSVEIAPKRSKKDRDKTWEYEEKDRRGSGDHRRSFDSRRSSGGRHRERSPEDSDEDSPPPSLSDLARKLKKKEKQKKRKAYEPKLTVDEMMDSSTFKRFTTSVDNILDNLEDVDLTSLDDDEIPQELLLGKHQLSELSSESAKIKAMGIMHKITHDKMVKVQSILEKNIQDGAKLSTLMNHDNDRDDEERLWRDLIMERVTKSADACLTALNIMTSARMPKAVYIEDVIERVVQYTKFHLQNTLYPQYDPVYRVDHHGGGTLSSKAKRAKCSTHKQRVTVMLYNKVCDIISNLSELLEIQLLTDTTILQISSLGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARLPTSKRNLRNYRLNSSDVDGEPMYIQMVTALVLQLIQCVVNLPSDKDSDEENDRKVDHDVLITNSYETAMRTAQNFLSVFLKKCGSKQGEDDYRPLFENFVQDLLSTVNKPDWPAAELLLSLLGRLLVHQFSNKQTEMALRVASLDYLGTVAARLRKDAVTSKMDQRSINRILGENSGSDEIQQLQKALLNYLDENVETDPFLLFARKFYLAQWYRDTSTETEKAMKSQRDDDSSDGPHHAKDVETTSEILQKAEARKKFLRSVIKTTASKFSSLRVNSDTVDYEDSCLIVRYLASMRPFAQSFDIYLTQILRVLGESAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLSRPQLTEQYYDMLIERILDTGISVRKRVIKILRDICLEQPTFNKVTEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPNHDKEAMTRKILNITDVVAACRDSGYDWFEQLLQNLLKSEEDASYKPARKACAQLVDSLVEHILKYEESLADCENKGLTSNRLVACITTLYLFSKIRPHLMVKHAMTMQPYLTTKCNTQSDFMVICNVAKILELVVPLMDHPSESFLTTIEEDLMKLIIKYGMTVVQHCVSCLGAVVNRVTHNYKFVWSCFNRYYGALSKLKMQHQEDPNSTVLVSNKPALLRSLFTVGALCRHFDFDQEEFKGSNKVVIKDKVLELLLYFTKNDDEEVQTKAIIGLGFLFIQDPGLMFVTEVKNLYNTLLADRKTSVNLKIQVLKNLQTYLQEEDSRMQEADREWNKLSKKEDLKEMGDISSGMSSSIMQLYLKQVLEAFFHTQSSVRHYALNVIALTLNQGLIHPVQCVPYLIAMGTDSEPTMRNKADQQLVEIDKKYTGFIHMKAVAGMKMSYQVQQAIVGSKDTVIRGFRLDESSTALCSHLYTMVRGNRQHRRAFLISLLNLFDDNTKSDVNMLLYIADNLASFPYQTQEEPMFIMHHVDITLSVSGSNLLQSFKESLLKEPRKVEVVKKKKKKKKKKKQKQKRGKKYGSEEEDESSRSSSSSSSSSSSSSDSDSSEEEVIHRRKKPRRTTANSDSDSDLDVEDVDKVMLRLPDNPEPLLDFANASQGILLLLMLKQHLKNLYGFSDSKIQKYSPTESAKIYDKAVNRKANVHFNPRQTLDYLTNSLSNSDLSNDVKRRVVRQYLDFKVLMEHLDPDEEEEEGEASASSHARNKAINALLGGSSPKNNAAESYDDDSEVEEKTPGSSRRSRRTGDSAEASGHRNETVEATDVIALCCPKYKDRPQIARVIQKTSKGYSIHWMAGSYSGTWAEAKKRDGRKLVPWVDTIKESDIIYKKIALTSAHKLSNKVVQTLRSLYAAKEGSSS
InterPro domains: - IPR033031: Scc2/Nipped-B family (family) [923-2875]
- IPR016024: Armadillo-type fold (homologous_superfamily) [1780-2545]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1750-2462]
- IPR024986: Sister chromatid cohesion C-terminal domain (domain) [2311-2491]
- IPR026003: HEAT repeat associated with sister chromatid cohesion protein (repeat) [1830-1871]
Interaction partners: - Structural maintenance of chromosomes protein
- Structural maintenance of chromosomes protein
- Double-strand-break repair protein rad21 homolog A
- PDS5 cohesin-associated factor B
- Sister chromatid cohesion protein PDS5 homolog A
- N-acetyltransferase ESCO2
- Cohesin subunit SA
- Cell division cycle-associated 5
- RAD21 cohesin complex component b
- Establishment of sister chromatid cohesion N-acetyltransferase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0019725 (cellular homeostasis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048736 (appendage development), GO:0048729 (tissue morphogenesis), GO:0070050 (neuron cellular homeostasis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0009799 (specification of symmetry), GO:0035107 (appendage morphogenesis), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0009790 (embryo development), GO:1904888 (cranial skeletal system development), GO:0035239 (tube morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0055123 (digestive system development), GO:0048562 (embryonic organ morphogenesis), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0033333 (fin development), GO:0003143 (embryonic heart tube morphogenesis), GO:0030111 (regulation of Wnt signaling pathway), GO:0002009 (morphogenesis of an epithelium), GO:0009855 (determination of bilateral symmetry), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0033334 (fin morphogenesis), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0001501 (skeletal system development), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0007417 (central nervous system development), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0060429 (epithelium development), GO:0048565 (digestive tract development), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0043009 (chordate embryonic development), GO:0007368 (determination of left/right symmetry), GO:0035118 (embryonic pectoral fin morphogenesis), GO:0048704 (embryonic skeletal system morphogenesis), GO:0003146 (heart jogging), GO:0048706 (embryonic skeletal system development), GO:0033339 (pectoral fin development), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0035138 (pectoral fin morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0000118 (histone deacetylase complex), GO:0070822 (Sin3-type complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)