Protein: Epithelial sodium channel subunit beta (Amiloride-sensitive sodium channel subunit beta) (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB) (H1AFJ6)
Organism: Neoceratodus forsteri (Australian lungfish) (Ceratodus forsteri)
Function: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.
Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:P51168}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51168}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51168}.
Sequence: MFLKRWFIRALHRLQKGPGYGYSELFVWYCNNTNTHGPKRLIIEGPKKKTLWSLFTVTFACLVFWQWGLLIQTYLSWGVSVSLSVGFRGMDFPAVTVCNVNPFKYSKVKPLLKELDELVDILLEQFYSYSTNGTLPVVFPDMRSSYLTGDPPPWYQIPLVMIDETDADNPTVTNVLGTDALSPTNNSTTNSSTEARRYKVAFHLCNTNGTDCFYKNFSSSLEAVKEWYTLQYIDIISKLPLSQKVEMGYSGKDFILTCLFGGEACNYDNFTQFYHSSYGNCYVFNWGLDGNVLIVSNPGVGFGLQLALDVNQEEYIPFLTTRAGARFLLHTQNTFPFVETMGTYALVGTVTSVGILVDEVQRMGQPYGTCTTDGLDVPIDNLYSQYNLSYTMQSCLWSCFQIQMVNSCGCAYYLYPLPEGATYCNNQNNSDWAYCYYLLQDSKDHKNECLQTCIQTCNELQFRISTSMADWPSESSEDWIFHVLSYERDDSTNITMKRDGVLKLNLYFKEFNYRVITESVATNVVWLLSNLGGQFGFWMGGSVLCIIEFGEVFIDCIWIAVIRFVKWYKNRKERQVQAQYADPPPTVSELVEGYTNQGFQPDIINSCSPQAQPPDLYLPTTLEIPGTPPPKYDSLRVHPIDTEHHSDSEDL
InterPro domains: - IPR020903: Epithelial sodium channel, conserved site (conserved_site) [390-410]
- IPR004724: Epithelial sodium channel, chordates (family) [22-635]
- IPR001873: Epithelial sodium channel (family) [24-560]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015280 (ligand-gated sodium channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006810 (transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055078 (sodium ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0006883 (intracellular sodium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:1902495 (transmembrane transporter complex), GO:0034702 (ion channel complex), GO:0034703 (cation channel complex), GO:0034706 (sodium channel complex)