wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Nonhistone chromosomal protein H6 (C1BFL7)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MPKRKSATKGDEPARRSARLSSRPAPKPAAKPKKAAAPKKPVKGKKAAENGDAKAEAKVEAAGDAK
InterPro domains: - IPR000079: High mobility group protein HMGN (family) [2-64]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70) (Q9H0G5)
Organism: Homo sapiens (Human)
Function: RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
Subcellular location: Nucleus {ECO:0000269|PubMed:21296756}. Nucleus speckle {ECO:0000269|PubMed:21296756}. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.
Sequence: MAIPGRQYGLILPKKTQQLHPVLQKPSVFGNDSDDDDETSVSESLQREAAKKQAMKQTKLEIQKALAEDATVYEYDSIYDEMQKKKEENNPKLLLGKDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRVNCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSRDQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAKTYIEKEDD
InterPro domains: - IPR018612: Nuclear speckle splicing regulatory protein 1, N-terminal (domain) [59-177]
- IPR046850: Nuclear speckle splicing regulatory protein 1, RS-like domain (domain) [293-470]
- IPR042816: Nuclear speckle splicing regulatory protein 1 (family) [1-558]
Interaction partners: - Cell division cycle 5-like protein
- Beta-catenin-like protein 1
- EF-hand calcium-binding domain-containing protein 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0001501 (skeletal system development), GO:0060348 (bone development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Protein psiM (Q54P69)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MKKINNNKIFVLFLTILLYLLNITTAQKPVSINIKIFDQLPLYNDNFGSQSRAATIKSMVATSLNTTFKTPSLGSATSSLPSPQLFQYWFQSNFANETKNSGLNAPLTRTITLNYDSDSGNYIFNNPNFFLIDTDGFDKTASNRIYKDSTGTYHNYHYCVAFNYVFKPDGQGKEMFKFTGNDDVWVFVNNKLLLDGGGVRSPEATTVDFTKAGLVKSQETPLDFFYCERSTNSPPSFKIETNLGGLYCKAYDYCGVCNGDGGTCCNPQTDCLTQLENGTLINDKCTIPICPPLDTQIDKNLGIGFFCQHSQIPDPYAGSLCEKGECDSLTGIWTRNTSICPTDKDLAPQCRKQATCDPKLGCQSTYLCNNVCDIGTCNNGTCTQKTSNDCVQELDRGVEDKCFTYKCVPNVGCSKTPICPRGTDPCKNYTCSGGICGTVDIPQSECSCPCPGLNKCNTRICNPDNTCTLFNLTEINDGNPCTDDLCDPVTGDITHVMTTRCSGCNTCDVKTGKCVAQDSHCDDGNPCTDNACVASANSTANSQVGQCTQTPTAKCDLGDKCMVYSCTLEGGCNATQRVCPNSGACKIGYCEPGFGCKLKDRVCSSDWYCIEAQCDAKYGCIQFDRRCAPDNSKCQEGVCVNNTAIGKNDGKCISEDYDPKPFVCQKAALVSTAVIASVVVVGAVVLGAAIFAGKKGYDAWKTSQGNVMAASQANPLYTQSSNGGENPLYNSPT
InterPro domains: - IPR051154: Prespore-cell-inducing factor (family) [11-391]
- IPR011874: Fibro-slime (domain) [153-243]
- IPR011658: PA14 domain (domain) [121-240]
- IPR037524: PA14/GLEYA domain (domain) [114-260]
Interaction partners: - Latrophilin receptor-like protein A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005516 (calmodulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0099120 (socially cooperative development), GO:0048856 (anatomical structure development), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0031152 (aggregation involved in sorocarp development), GO:0033554 (cellular response to stress), GO:0030587 (sorocarp development), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: WNK lysine deficient protein kinase 2 (H0Y7J9)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: XAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARA
InterPro domains: - IPR050588: With No Lysine (K) Ser/Thr Protein Kinase (family) [254-471]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Chitinase domain-containing protein 1 (Q9M159)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MARRRRSSAAESLKRRNDGYESLCQVVQQDSDRRLITIFVIFFIVIPAVSIAVYKVKFADRVIQTESSIRQKGIVKTDINFQEILTEHSKASENSTRHYDYPVLAYITPWNSKGYDMAKIFNSKFTHLSPVWYDLKSQGSGLVLEGRHNADKGWIQELRSRGNALILPRVVLEAIPGEMLNKKKLREKAISLIVTECKEMEYNGIVLESWSRWAAYGVLHDPDLRKMALKFVKQLGDALHSTSSPRNNQQHMQFMYVVGPPRSEKLQMYDFGPEDLQFLKDSVDGFSLMTYDFSNPQNPGPNAPVKWIDLTLKLLLGSSNNIDSNIARKVLLGINFYGNDFVISGDSGGGGAITGRDYLALLQKHKPTFRWDKESGEHLFMYRDDKNIKHAVFYPTLMSILLRLENARLWGIGISIWEIGQGLDYFFDLL
InterPro domains: - IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [102-427]
- IPR011583: Chitinase II/V-like, catalytic domain (domain) [101-422]
- IPR001223: Glycoside hydrolase family 18, catalytic domain (domain) [101-430]
- IPR029070: Chitinase insertion domain superfamily (homologous_superfamily) [338-394]
Interaction partners: - AT3g12300/F28J15_117
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030246 (carbohydrate binding), GO:0005515 (protein binding), GO:0070492 (oligosaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009611 (response to wounding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0032588 (trans-Golgi network membrane), GO:0031982 (vesicle), GO:0005802 (trans-Golgi network), GO:0097708 (intracellular vesicle)
Protein: Mitochrondria associated protein (T3SS secreted effector Map) (Q7DB76)
Organism: Escherichia coli O157:H7
Function: Not known
Sequence: MFSPMTMAGRSLVQATAQTLKPAVTRAAMQAGTGATGMRFMPVQSNFVINHGKLTNQLLQAVAKQTRNGDTQQWFQQEQTTYISRTVNRTLDDYCRSNNSVISKETKGHIFRAVENALQQPLDMNGAQSSIGHFLQSNKYFNQKVDEQCGKRVDPITRFNTQTKMIEQVSQEIFERNFSGFKVSEIKAITQNAILEHVQDTRL
InterPro domains: - IPR004959: Bacterial effector protein IpgB-like (family) [49-184]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051051 (negative regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0040013 (negative regulation of locomotion), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0045806 (negative regulation of endocytosis), GO:0060341 (regulation of cellular localization), GO:0032387 (negative regulation of intracellular transport), GO:2000146 (negative regulation of cell motility), GO:0051223 (regulation of protein transport), GO:0032880 (regulation of protein localization), GO:0030334 (regulation of cell migration), GO:0030336 (negative regulation of cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Decorin (Bone proteoglycan II) (Q803T1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490, ECO:0000256|RuleBase:RU364097}.
Sequence: MKSACLSLLLVSVCWALPFRQSGFMDFVMEDEPASGDGPGPELPTTRKPHVERLPMMPEGPEVPFCPFRCQCHLRVAQCSDLGLKTVPEKIPLDTTLLDLQNNKITEIKENDFKGLKGLQTLILVNNKITIIHAKAFSSLINLERLYLSKNLLKEVPANIPKSLQELRIHENQINKIKKSSFAGMANVIVMELGSNPLSSSGVDNGAFADLKRVSYIRIADTNLTSIPKGLPSSLFELHLDGNKITKVTADSLKGLKNLSKLGLSHNEISVVENGSLANVPHLRELHLENNALTAVPAGLADHKYIQVIYLHSNKIAAVGTEDFCPPGYNTKKAMYSGISLFSNPVPYWEVLPITFRCVFDRSAIQLGNYRKK
InterPro domains: - IPR050333: Small Leucine-Rich Proteoglycans (family) [50-369]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [64-371]
- IPR000372: Leucine-rich repeat N-terminal domain (domain) [65-97]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [96-303]
- IPR001611: Leucine-rich repeat (repeat) [97-293]
- IPR016352: Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan (family) [1-372]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072359 (circulatory system development), GO:0007507 (heart development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0005886 (plasma membrane), GO:0042383 (sarcolemma), GO:0062023 (collagen-containing extracellular matrix)
Protein: Olfactomedin 2 (K7EIS8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse {ECO:0000256|ARBA:ARBA00034103}.
Sequence: MEVLELRTYRDLQYVRGMETLMRSLDARLRAADGSLSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGSLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITVRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVMRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTSGDP
InterPro domains: - IPR050605: Olfactomedin-like domain-containing protein (family) [3-365]
- IPR022082: Noelin domain (domain) [1-43]
- IPR003112: Olfactomedin-like domain (domain) [116-368]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0050793 (regulation of developmental process), GO:0140352 (export from cell), GO:0051094 (positive regulation of developmental process), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0045597 (positive regulation of cell differentiation), GO:0045595 (regulation of cell differentiation), GO:0032940 (secretion by cell), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0051149 (positive regulation of muscle cell differentiation), GO:0035592 (establishment of protein localization to extracellular region), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:0008104 (protein localization), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0051147 (regulation of muscle cell differentiation), GO:0015031 (protein transport), GO:0051150 (regulation of smooth muscle cell differentiation), GO:0071692 (protein localization to extracellular region)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005576 (extracellular region), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2) (Q01362)
Organism: Homo sapiens (Human)
Function: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSPPIDL
InterPro domains: - IPR007237: CD20-like family (family) [60-203]
- IPR030417: Membrane-spanning 4-domains subfamily A (family) [44-202]
Interaction partners: - High affinity immunoglobulin epsilon receptor subunit alpha
- High affinity immunoglobulin epsilon receptor subunit gamma
- Tyrosine-protein kinase Lyn
- Tyrosine-protein kinase SYK
- Mast cell carboxypeptidase A
- Immunoglobulin heavy variable 4-38-2
- Tyrosine-protein kinase Fyn
- Membrane-spanning 4-domains subfamily A member 5
- Tryptase alpha/beta-1
- Histidine decarboxylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0019865 (immunoglobulin binding), GO:0019863 (IgE binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0035579 (specific granule membrane)
Protein: Tyrosine-protein phosphatase 2 (EC 3.1.3.48) (Protein-tyrosine-phosphate phosphohydrolase 2) (PTPA) (P34138)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Sequence: MDESFDAFEIKPNSSIIEHFNNHPTCIDKEFNFILQKTELRALETDKFRSALEAKNKLKNRYSNVLPFEETRVKINIDDDDDDEDDNEDDIIVSNNNNNNNNNEKRIKRNSIGSSGQSDVMSNSSDEEDHGGSGDEGTTLSDYINASFINNGTYICTQGPLLNTIVDFWKMIWEQNSNIIVMLTREEENFKTKCDKYWPDKDEERYGNFIVKFDNNITIPDILIRREFTLENLKDNKTRKIYHFQYTTWPDHGTPVSTTGFLKFVSFVDHEKRSGPIVVHCSAGIGRSGTFVAIHSIVAKFAKHYDEKKQAPSINLPKLVVEMRNERPGMVQTRDQYRFCYLAISEAMNTVLKKEQKKRKGLSYSYSSIPLTGPEHD
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [13-366]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [262-338]
- IPR050348: Protein-Tyrosine Phosphatase (family) [23-356]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [240-346]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [279-289]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [26-349]
Interaction partners: - Extracellular signal-regulated kinase 1
- Probable serine/threonine-protein kinase roco5
- Probable serine/threonine-protein kinase roco8
- Probable serine/threonine-protein kinase qkgA
- Probable serine/threonine-protein kinase roco6
- Probable serine/threonine-protein kinase roco11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0035556 (intracellular signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)