Protein: Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain] (O09107)
Organism: Mus musculus (Mouse)
Function: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity).
Subcellular location: Secreted.
Sequence: MRAPLLLMLLALGSALRSPQPPEARAKLCGHHLVRTLVRVCGGPRWSPEATQPVETRDRELLQWLEQRHLLHALVADVDPALDPQLPRQASQRQRRSAATNAVHRCCLTGCTQQDLLGLCPH
InterPro domains: - IPR016179: Insulin-like (domain) [26-120]
- IPR043387: Insulin-like INSL3/INSL4 (family) [4-122]
- IPR036438: Insulin-like superfamily (homologous_superfamily) [15-120]
- IPR022353: Insulin, conserved site (conserved_site) [106-120]
- IPR022352: Insulin/IGF/relaxin (family) [27-120]
Interaction partners: - Relaxin receptor 2
- Relaxin receptor 1
- Relaxin-3 receptor 1
- Prorelaxin 1
- Relaxin-3
- Relaxin-3 receptor 2
- Insulin-like peptide INSL5
- Steroid 17-alpha-hydroxylase/17,20 lyase
- 17-beta-hydroxysteroid dehydrogenase type 3
- Steroidogenic acute regulatory protein, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:2000241 (regulation of reproductive process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0007018 (microtubule-based movement), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048515 (spermatid differentiation), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0030317 (flagellated sperm motility), GO:0032886 (regulation of microtubule-based process), GO:0048240 (sperm capacitation), GO:1901317 (regulation of flagellated sperm motility), GO:2000147 (positive regulation of cell motility), GO:0007283 (spermatogenesis), GO:0071695 (anatomical structure maturation), GO:1902019 (regulation of cilium-dependent cell motility), GO:2000155 (positive regulation of cilium-dependent cell motility), GO:0060632 (regulation of microtubule-based movement), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0003352 (regulation of cilium movement), GO:0060295 (regulation of cilium movement involved in cell motility), GO:0060294 (cilium movement involved in cell motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)