Protein: Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP) (Q99NH2)
Organism: Mus musculus (Mouse)
Function: Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination.
Subcellular location: Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction {ECO:0000269|PubMed:10934475, ECO:0000269|PubMed:20080746}. Cell junction, adherens junction {ECO:0000269|PubMed:20080746}. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalized with SIRT2 in internode region of myelin sheath. {ECO:0000250}.
Sequence: MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASFTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPAAPALAPPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQTPKETKAEDEDVVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLVADETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPEKRDKTERKKDKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRKDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQRQRQEERESFQQAQRQYSSLPRQSRKNASSISQDSWEQNYAPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGVRGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [265-685]
- IPR021922: Par3/HAL, N-terminal (domain) [1-83]
- IPR001478: PDZ domain (domain) [271-684]
- IPR052213: Partitioning defective 3 homolog (family) [1-1333]
Interaction partners: - Partitioning defective 6 homolog alpha
- Protein kinase C zeta type
- Partitioning defective 6 homolog beta
- Cell division control protein 42 homolog
- Partitioning defective 6 homolog gamma
- Protein kinase C iota type
- Rho guanine nucleotide exchange factor TIAM1
- Nectin-1
- Junctional adhesion molecule A
- Junctional adhesion molecule C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007163 (establishment or maintenance of cell polarity), GO:0008283 (cell population proliferation), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007272 (ensheathment of neurons), GO:0061842 (microtubule organizing center localization), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0030029 (actin filament-based process), GO:0051606 (detection of stimulus), GO:0040008 (regulation of growth), GO:0051640 (organelle localization), GO:0051642 (centrosome localization), GO:0048638 (regulation of developmental growth), GO:0061351 (neural precursor cell proliferation), GO:0048729 (tissue morphogenesis), GO:0008366 (axon ensheathment), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0001558 (regulation of cell growth), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0051649 (establishment of localization in cell), GO:0009595 (detection of biotic stimulus), GO:0030036 (actin cytoskeleton organization), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0060322 (head development), GO:0051656 (establishment of organelle localization), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0061245 (establishment or maintenance of bipolar cell polarity), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0007405 (neuroblast proliferation), GO:0032535 (regulation of cellular component size), GO:0022604 (regulation of cell morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0060245 (detection of cell density), GO:0048864 (stem cell development), GO:0031344 (regulation of cell projection organization), GO:0042552 (myelination), GO:0048880 (sensory system development), GO:0035088 (establishment or maintenance of apical/basal cell polarity), GO:0007423 (sensory organ development), GO:0032292 (peripheral nervous system axon ensheathment), GO:0090596 (sensory organ morphogenesis), GO:0021782 (glial cell development), GO:0010001 (glial cell differentiation), GO:0021535 (cell migration in hindbrain), GO:0035845 (photoreceptor cell outer segment organization), GO:0002009 (morphogenesis of an epithelium), GO:0060485 (mesenchyme development), GO:0048666 (neuron development), GO:0001667 (ameboidal-type cell migration), GO:0007420 (brain development), GO:0061387 (regulation of extent of cell growth), GO:0032291 (axon ensheathment in central nervous system), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0050770 (regulation of axonogenesis), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0048670 (regulation of collateral sprouting), GO:0072359 (circulatory system development), GO:0007422 (peripheral nervous system development), GO:0007417 (central nervous system development), GO:0008104 (protein localization), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0008360 (regulation of cell shape), GO:0014033 (neural crest cell differentiation), GO:0001838 (embryonic epithelial tube formation), GO:0045176 (apical protein localization), GO:0043009 (chordate embryonic development), GO:0051493 (regulation of cytoskeleton organization), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:1902414 (protein localization to cell junction), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0048048 (embryonic eye morphogenesis), GO:0014003 (oligodendrocyte development), GO:0048709 (oligodendrocyte differentiation), GO:0046530 (photoreceptor cell differentiation), GO:0022011 (myelination in peripheral nervous system), GO:0014044 (Schwann cell development), GO:0090497 (mesenchymal cell migration), GO:0150063 (visual system development), GO:0007010 (cytoskeleton organization), GO:0042461 (photoreceptor cell development), GO:0042063 (gliogenesis), GO:0035904 (aorta development), GO:0061154 (endothelial tube morphogenesis), GO:0048699 (generation of neurons), GO:0014037 (Schwann cell differentiation), GO:0003158 (endothelium development), GO:0014032 (neural crest cell development), GO:0045197 (establishment or maintenance of epithelial cell apical/basal polarity), GO:0043010 (camera-type eye development), GO:0035907 (dorsal aorta development), GO:0001755 (neural crest cell migration), GO:0010975 (regulation of neuron projection development), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0045211 (postsynaptic membrane), GO:0098797 (plasma membrane protein complex), GO:0032103 (positive regulation of response to external stimulus), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0098890 (extrinsic component of postsynaptic membrane), GO:0099243 (extrinsic component of synaptic membrane), GO:0005911 (cell-cell junction), GO:0098978 (glutamatergic synapse)