Protein: Ribosomal protein S6 kinase beta-2 (S6K-beta-2) (S6K2) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 2) (P70S6K2) (p70-S6K 2) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14B) (p70 ribosomal S6 kinase beta) (S6K-beta) (p70 S6 kinase beta) (p70 S6K-beta) (p70 S6KB) (p70-beta) (Q9UBS0)
Organism: Homo sapiens (Human)
Function: Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7.
Subcellular location: Cytoplasm. Nucleus.
Sequence: MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [65-385]
- IPR000719: Protein kinase domain (domain) [67-328]
- IPR000961: AGC-kinase, C-terminal (domain) [329-399]
- IPR016238: Ribosomal protein S6 kinase (family) [3-436]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [190-202]
- IPR017441: Protein kinase, ATP binding site (binding_site) [73-99]
- IPR017892: Protein kinase, C-terminal (domain) [349-389]
Interaction partners: - Small ribosomal subunit protein eS6
- Serine/threonine-protein kinase mTOR
- Regulatory-associated protein of mTOR
- Insulin receptor substrate 1
- Target of rapamycin complex subunit LST8
- Proline-rich AKT1 substrate 1
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Eukaryotic translation initiation factor 4B
- 3-phosphoinositide-dependent protein kinase 1
- DEP domain-containing mTOR-interacting protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0006793 (phosphorus metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0035556 (intracellular signal transduction), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043491 (protein kinase B signaling), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)