Protein: GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) (P38625)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not known
Subcellular location: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9P772}.
Sequence: MAAGEQVSNMFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKISELGWTPKGVILSGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQVGRGDKREYGPATLKVIDDSNSLFKGMNDSTVWMSHGDKLHGLPTGYKTIATSDNSPYCGIVHETKPIYGIQFHPEVTHSTQGKTLLKNFAVDLCHAKQNWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLYNQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE
InterPro domains: - IPR029062: Class I glutamine amidotransferase-like (homologous_superfamily) [7-233]
- IPR025777: GMP synthetase ATP pyrophosphatase domain (domain) [203-400]
- IPR017926: Glutamine amidotransferase (domain) [15-195]
- IPR022955: GMP synthase (family) [11-525]
- IPR022310: NAD/GMP synthase (domain) [224-290]
- IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [204-410]
- IPR001674: GMP synthase, C-terminal (domain) [207-525]
- IPR004739: GMP synthase, glutamine amidotransferase (domain) [14-199]
Interaction partners: - Inosine-5'-monophosphate dehydrogenase 3
- Inosine-5'-monophosphate dehydrogenase 4
- Inosine-5'-monophosphate dehydrogenase 2
- Guanylate kinase
- Adenine phosphoribosyltransferase 1
- Adenine phosphoribosyltransferase 2
- Hypoxanthine-guanine phosphoribosyltransferase
- Ubiquitin carboxyl-terminal hydrolase 15
- Inosine triphosphate pyrophosphatase
- CTP synthase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0016884 (carbon-nitrogen ligase activity, with glutamine as amido-N-donor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0019693 (ribose phosphate metabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0009161 (ribonucleoside monophosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009126 (purine nucleoside monophosphate metabolic process), GO:0046037 (GMP metabolic process), GO:0009167 (purine ribonucleoside monophosphate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)