Protein: Serine/threonine-protein kinase ppk5 (EC 2.7.11.1) (Meiotically up-regulated gene 189 protein) (Q09815)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Has a role in meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Note=Septum.
Sequence: MVGLISTSETLPKQESKSSSAPVSNFLSPNNLTEQTCSPLRAHSTFKEPVFLLSQRQYSHNSKILTELINSVKRPNKPDQNEEKSAVGIEEKSFKDEHLAQKKGLHHFADLKEIFLNKNLSTLDGLQDASLHDNIQSGKLDNPVISQNRRIVLEKLANPNSSKEYETIPTVENRHPLNKLSKTKTLAYEETINQLDETPGGTNYPMNKKKTLSSETNKYEYPQQSKFHECSQFASPRSSIVNGPRTLGKNSKRADDTARMASRMKPSNFNNNIQSSSYGHASQSTKLTSQRDNDHQKDLNFSPYKSIPLNNRPYSPMSEIVGFSGSTTPLDTYGNRPSGKKFNKNSKFRPPGSTISSYSSASTLRRLPRAPGSKVHAERQNSTFNSGISLRALRKEMGNTAPVSSNQLLKDADLVMENLSTRNTEKVLREVNILKRLRESCVAITAKSYDTLDERKIRSLTTFEYLEIKNFQKIYFTGSENCQKLSKQIPLDECNEALFDDDNGDYKAIQGDHLLYRYEIIDTVGKGSFGQVLKCIDHKRGQVVAIKVIKNRQKFHGQTLVEVGILKRLCEADPADKNNVIRYLSHFDFRGHLCIVTELLGSNLFDVIRENNYKGLPLIVVKSFALQGLQALRLLQGQNIIHCDLKPENLLLSHPLKARIKLIDFGSSCFYNEKVYTYLQSRFYRAPEIILGLEYGKEIDIWSFGCILAELFTGVPLFPGGNETEQLGYIMEVLGPPPMALIRNSTRSKAYFDSEGKPHPITDSHNRLLVPSTRTFSQLLNTKQASFLDFLSKCLKWDPKDRITVDSALQHEFILGKTSQKPMVSKGSHPLPDLPV
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [508-820]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [640-652]
- IPR050494: Serine/threonine and dual-specificity kinase (family) [265-814]
- IPR017441: Protein kinase, ATP binding site (binding_site) [524-547]
- IPR000719: Protein kinase domain (domain) [518-814]
Interaction partners: - Uncharacterized WD repeat-containing protein C17D11.08
- DYRK-family kinase pom1
- Serine/threonine-protein kinase plo1
- Cell division control protein 7
- Serine/threonine-protein kinase tel1
- Septum-promoting GTP-binding protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0008289 (lipid binding), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0005543 (phospholipid binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0035091 (phosphatidylinositol binding), GO:0016301 (kinase activity), GO:1901981 (phosphatidylinositol phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0007163 (establishment or maintenance of cell polarity), GO:0032879 (regulation of localization), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0045927 (positive regulation of growth), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0030029 (actin filament-based process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:0051302 (regulation of cell division), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0090068 (positive regulation of cell cycle process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:1903828 (negative regulation of protein localization), GO:0080134 (regulation of response to stress), GO:0060341 (regulation of cellular localization), GO:0001558 (regulation of cell growth), GO:0080135 (regulation of cellular response to stress), GO:0051781 (positive regulation of cell division), GO:0009966 (regulation of signal transduction), GO:0030307 (positive regulation of cell growth), GO:0010948 (negative regulation of cell cycle process), GO:0030036 (actin cytoskeleton organization), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0010646 (regulation of cell communication), GO:0032878 (regulation of establishment or maintenance of cell polarity), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0061245 (establishment or maintenance of bipolar cell polarity), GO:0070727 (cellular macromolecule localization), GO:0045786 (negative regulation of cell cycle), GO:0016043 (cellular component organization), GO:0030952 (establishment or maintenance of cytoskeleton polarity), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0048638 (regulation of developmental growth), GO:0030950 (establishment or maintenance of actin cytoskeleton polarity), GO:0022604 (regulation of cell morphogenesis), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0032954 (regulation of cytokinetic process), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0032465 (regulation of cytokinesis), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0032880 (regulation of protein localization), GO:1902532 (negative regulation of intracellular signal transduction), GO:0032467 (positive regulation of cytokinesis), GO:2000769 (regulation of establishment or maintenance of cell polarity regulating cell shape), GO:0051510 (regulation of unidimensional cell growth), GO:1904376 (negative regulation of protein localization to cell periphery), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:1905476 (negative regulation of protein localization to membrane), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:1902531 (regulation of intracellular signal transduction), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0008360 (regulation of cell shape), GO:0043408 (regulation of MAPK cascade), GO:1905475 (regulation of protein localization to membrane), GO:1903490 (positive regulation of mitotic cytokinesis), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0007010 (cytoskeleton organization), GO:1902412 (regulation of mitotic cytokinesis), GO:1903436 (regulation of mitotic cytokinetic process), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1903438 (positive regulation of mitotic cytokinetic process), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0070303 (negative regulation of stress-activated protein kinase signaling cascade), GO:1904375 (regulation of protein localization to cell periphery), GO:1903077 (negative regulation of protein localization to plasma membrane), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0043409 (negative regulation of MAPK cascade), GO:0032873 (negative regulation of stress-activated MAPK cascade), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:1903076 (regulation of protein localization to plasma membrane), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030427 (site of polarized growth), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0070938 (contractile ring), GO:0032153 (cell division site), GO:0097574 (lateral part of cell), GO:0005737 (cytoplasm), GO:0051286 (cell tip), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0043228 (non-membrane-bounded organelle), GO:0005826 (actomyosin contractile ring), GO:0110085 (mitotic actomyosin contractile ring), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0099738 (cell cortex region), GO:0051285 (cell cortex of cell tip), GO:0030864 (cortical actin cytoskeleton), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)