Protein: Heat shock transcription factor 1 (E9PMQ6)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDNLARTPQMSRVARLFPCPSSSPHGQVQPGNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDIQELLSPQEPPRPPEAENSSPDSAGALHSAAAVPAGPRLRGHREQRPAGAV
InterPro domains: - IPR000232: Heat shock factor (HSF)-type, DNA-binding (domain) [14-118]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [13-118]
- IPR010542: Vertebrate heat shock transcription factor, C-terminal domain (domain) [247-468]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [11-120]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0001217 (DNA-binding transcription repressor activity), GO:0042802 (identical protein binding), GO:0043621 (protein self-association), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0031072 (heat shock protein binding), GO:0046983 (protein dimerization activity), GO:0031490 (chromatin DNA binding), GO:0019899 (enzyme binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0051879 (Hsp90 protein binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0019900 (kinase binding), GO:0140296 (general transcription initiation factor binding), GO:0046982 (protein heterodimerization activity), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:0003690 (double-stranded DNA binding), GO:0019901 (protein kinase binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009266 (response to temperature stimulus), GO:0051129 (negative regulation of cellular component organization), GO:0044085 (cellular component biogenesis), GO:0009314 (response to radiation), GO:0080134 (regulation of response to stress), GO:0060255 (regulation of macromolecule metabolic process), GO:1903706 (regulation of hemopoiesis), GO:0006725 (cellular aromatic compound metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0045787 (positive regulation of cell cycle), GO:0046685 (response to arsenic-containing substance), GO:0009408 (response to heat), GO:0051726 (regulation of cell cycle), GO:2001021 (negative regulation of response to DNA damage stimulus), GO:0010035 (response to inorganic substance), GO:1901360 (organic cyclic compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0035966 (response to topologically incorrect protein), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:1903708 (positive regulation of hemopoiesis), GO:0051128 (regulation of cellular component organization), GO:1902074 (response to salt), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:1901576 (organic substance biosynthetic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:2000026 (regulation of multicellular organismal development), GO:0104004 (cellular response to environmental stimulus), GO:1901698 (response to nitrogen compound), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:1902075 (cellular response to salt), GO:0000165 (MAPK cascade), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0045637 (regulation of myeloid cell differentiation), GO:0045639 (positive regulation of myeloid cell differentiation), GO:0051053 (negative regulation of DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0034605 (cellular response to heat), GO:1902105 (regulation of leukocyte differentiation), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0043933 (protein-containing complex organization), GO:0051252 (regulation of RNA metabolic process), GO:0010212 (response to ionizing radiation), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010467 (gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:1900034 (regulation of cellular response to heat), GO:0071478 (cellular response to radiation), GO:0010038 (response to metal ion), GO:0051052 (regulation of DNA metabolic process), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:1901699 (cellular response to nitrogen compound), GO:0045931 (positive regulation of mitotic cell cycle), GO:0045738 (negative regulation of DNA repair), GO:2001020 (regulation of response to DNA damage stimulus), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0031333 (negative regulation of protein-containing complex assembly), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0035967 (cellular response to topologically incorrect protein), GO:0071243 (cellular response to arsenic-containing substance), GO:0071241 (cellular response to inorganic substance), GO:1902107 (positive regulation of leukocyte differentiation), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006986 (response to unfolded protein), GO:0051253 (negative regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0016070 (RNA metabolic process), GO:0065003 (protein-containing complex assembly), GO:2001141 (regulation of RNA biosynthetic process), GO:0034620 (cellular response to unfolded protein), GO:0046686 (response to cadmium ion), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0002763 (positive regulation of myeloid leukocyte differentiation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:1903311 (regulation of mRNA metabolic process), GO:0006282 (regulation of DNA repair), GO:2000780 (negative regulation of double-strand break repair), GO:0071479 (cellular response to ionizing radiation), GO:0006355 (regulation of DNA-templated transcription), GO:0010332 (response to gamma radiation), GO:0071248 (cellular response to metal ion), GO:0046688 (response to copper ion), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:1903313 (positive regulation of mRNA metabolic process), GO:0045649 (regulation of macrophage differentiation), GO:0045651 (positive regulation of macrophage differentiation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0050684 (regulation of mRNA processing), GO:0016071 (mRNA metabolic process), GO:0071280 (cellular response to copper ion), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071276 (cellular response to cadmium ion), GO:2000779 (regulation of double-strand break repair), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0050685 (positive regulation of mRNA processing), GO:0071480 (cellular response to gamma radiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:2001032 (regulation of double-strand break repair via nonhomologous end joining), GO:0031440 (regulation of mRNA 3'-end processing), GO:0009299 (mRNA transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)