Protein: Ago1p (A0A1D8PMK0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Sequence: MSDLVKFSTPTKINDKALVAIDTYKKTFQKQIKNEQNGILLRPSFGTEGVPTIVGVNYFKYNVNGLKLYSYRVDLLEDPNVKTRLSIKTAVEKYLMELEPFKSKKAIIYYRDHNHLYSRMPLPIEDVVIYPLELGGDPKREKKIVELKIQFIKQLNFSDLLNYTQLKNYTPDFLETVEYTNALVAVMGSQVMKNTNVVGLGPNKFFLMDGATKTTDLDKGLYVVMGTFASVRCSFDDVRINLNPTPAIFYKSSKPNGQPMNVLDLIQEFLKIRNVPTERDIRRAQSFIKGCKIYRTYLNRKTTKPILGFDYSNNSETLKFKDANDKLVNVKQYFQERWNIRLKHPTLPLIKIGPEAFLPMKLGIIAPHQQYKGDFADPAKIIKITATRPNQKAELISKTNRNLFQKQVDFGTIESQFTVVPARVLNAPTIEYANNQMVTYRPAPFNGRTEKQKGNWNLERYQFVDGAKLTKPMGKPFTFGVVILKDEFVAKRIGDLQRAVPTFLTELGRLGIKIGKNFKKYSIDLNHASVQSQTGLESNIISIAKKAKTEDQCNFLLFILPRQDTPLYSAIKRACDLKVGILNSCSILNTFTKKRRGTENFDAMTYAQMAMKINIKLGGSNHKLSKKDSQGLFDKNNVPIFILGADVTHPTGEINSESVSIASIVGSEDEIFNKFPGSVRIQTGGQEVIADVKSMVLERLENFHKKIGKLPSKVLFYRDGVSEGQYTTILKEELTKIKAAFNEYGKLKNIPKYSPTITFMIVVKRHHTRFIPIHDNADDPKTKKQIAVTSNENVIAGTTVDREITSPAYFDFYVQSQQSLQGTGIPAHYYVLHDENNYTSDTIQKITYDLCHTFSRATKSVKVVPAAYYADLLCTRGRDYIYGFAKDPNLKGSPIERARTKFGENVNPSIKNTMFYI
InterPro domains: - IPR003100: PAZ domain (domain) [260-387]
- IPR045246: Argonaute-like, PIWI domain (domain) [409-881]
- IPR032474: Protein argonaute, N-terminal (domain) [52-177]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [540-880]
- IPR003165: Piwi domain (domain) [555-882]
- IPR014811: Argonaute, linker 1 domain (domain) [198-252]
- IPR036085: PAZ domain superfamily (homologous_superfamily) [258-402]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [635-917]
Interaction partners: - Rgp1p
- Nucleoporin NSP1
- Nucleoporin
- ribonuclease III
- Mediator of RNA polymerase II transcription subunit 1
- DNA-directed RNA polymerase subunit
- Karyopherin
- Cdl1p
- Anaphase-promoting complex subunit 5
- Mitochondrial 54S ribosomal protein YmL3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0061980 (regulatory RNA binding), GO:0035197 (siRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0019222 (regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0016070 (RNA metabolic process), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0070918 (regulatory ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0030422 (siRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex), GO:0030684 (preribosome), GO:0032040 (small-subunit processome)