Protein: Pro-cathepsin H (Cathepsin B3) (Cathepsin BA) [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] (P49935)
Organism: Mus musculus (Mouse)
Function: Important for the overall degradation of proteins in lysosomes.
Subcellular location: Lysosome.
Sequence: MWAALPLLCAGAWLLSTGATAELTVNAIEKFHFKSWMKQHQKTYSSVEYNHRLQMFANNWRKIQAHNQRNHTFKMALNQFSDMSFAEIKHKFLWSEPQNCSATKSNYLRGTGPYPSSMDWRKKGNVVSPVKNQGACGSCWTFSTTGALESAVAIASGKMLSLAEQQLVDCAQAFNNHGCKGGLPSQAFEYILYNKGIMEEDSYPYIGKDSSCRFNPQKAVAFVKNVVNITLNDEAAMVEAVALYNPVSFAFEVTEDFLMYKSGVYSSKSCHKTPDKVNHAVLAVGYGEQNGLLYWIVKNSWGSQWGENGYFLIERGKNMCGLAACASYPIPQV
InterPro domains: - IPR013128: Peptidase C1A (family) [28-324]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [294-313]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [133-144]
- IPR039417: Papain-like cysteine endopeptidase (domain) [115-329]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [114-330]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [30-331]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [277-287]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [33-88]
Interaction partners: - Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- BH3-interacting domain death agonist
- Napsin-A
- Pulmonary surfactant-associated protein B
- Surfactant protein C
- Cystatin-A
- Toll-like receptor 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0008238 (exopeptidase activity), GO:0004180 (carboxypeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0009653 (anatomical structure morphogenesis), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0042303 (molting cycle), GO:0006807 (nitrogen compound metabolic process), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0045058 (T cell selection), GO:0009056 (catabolic process), GO:0065008 (regulation of biological quality), GO:0044706 (multi-multicellular organism process), GO:0044237 (cellular metabolic process), GO:0022404 (molting cycle process), GO:0044703 (multi-organism reproductive process), GO:0050794 (regulation of cellular process), GO:0032963 (collagen metabolic process), GO:0019882 (antigen processing and presentation), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0048729 (tissue morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0042633 (hair cycle), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0031069 (hair follicle morphogenesis), GO:0006725 (cellular aromatic compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0060135 (maternal process involved in female pregnancy), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0046649 (lymphocyte activation), GO:0045165 (cell fate commitment), GO:0042403 (thyroid hormone metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0007565 (female pregnancy), GO:0042127 (regulation of cell population proliferation), GO:0043368 (positive T cell selection), GO:0009888 (tissue development), GO:0050673 (epithelial cell proliferation), GO:0030574 (collagen catabolic process), GO:0001942 (hair follicle development), GO:0001893 (maternal placenta development), GO:0022405 (hair cycle process), GO:0048002 (antigen processing and presentation of peptide antigen), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0046697 (decidualization), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0002360 (T cell lineage commitment), GO:0030163 (protein catabolic process), GO:0002009 (morphogenesis of an epithelium), GO:0043616 (keratinocyte proliferation), GO:0043588 (skin development), GO:0001890 (placenta development), GO:0030098 (lymphocyte differentiation), GO:0043369 (CD4-positive or CD8-positive, alpha-beta T cell lineage commitment), GO:0050678 (regulation of epithelial cell proliferation), GO:0018958 (phenol-containing compound metabolic process), GO:0009057 (macromolecule catabolic process), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0009100 (glycoprotein metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0006590 (thyroid hormone generation), GO:0044265 (cellular macromolecule catabolic process), GO:0008544 (epidermis development), GO:0042110 (T cell activation), GO:0060429 (epithelium development), GO:0030217 (T cell differentiation), GO:0098773 (skin epidermis development), GO:0051603 (proteolysis involved in protein catabolic process), GO:0048730 (epidermis morphogenesis), GO:1903131 (mononuclear cell differentiation), GO:0010837 (regulation of keratinocyte proliferation), GO:0002363 (alpha-beta T cell lineage commitment), GO:0010839 (negative regulation of keratinocyte proliferation), GO:0006516 (glycoprotein catabolic process), GO:0046631 (alpha-beta T cell activation), GO:0035710 (CD4-positive, alpha-beta T cell activation), GO:0046632 (alpha-beta T cell differentiation), GO:0043367 (CD4-positive, alpha-beta T cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)