Protein: Coatomer subunit alpha (A0A1D8PJB0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
Sequence: MKMLTKFESKSSRAKGVAFHPKRPWALVSLHSSTIQLWDYRMGTLIDRFEDHVGPVRSVDFHPTQPLFVSGGDDYTIKVWSLNTRKCIFTLNGHLDYIRGVSFHHDLPWIISCSDDQTIRIWNWQNRQEIACLTGHNHYVMSAQFHPSEDLIVSASLDQTVRVWDISGLRKKHSAPTSSVRAFEDQLQRQQLPQQDIFGNINAVVKYVLEGHDKGVNYASFHPTLPLIVSAGDDRVVKLWRMSDTKAWEVDTCRGHTGNVLSAIFHPHQDLILSVSDDKTIRVWDLNKRVPVKQFRREHDRFWLIASHPTISLFAACHDSGIMVFKLERERPAHTIFQNKLYYVNGEKQIQTFDINKQENSLPMLSLKKIGKTWSFMRTLSYNQSDNSVLVVHGEGDNGNYALITLPKHVTGAIEPTDIRQGEANFAAFISRNRFVTFVKSTKTLQVKDLNNNITKTVQLDSSIVDVLPGSPGRILLVKAHSVINYDVQQRKELAEISVNNVKYVSWSSNGQYLALLSKHTITIADKDLELITSMHETIRIKSAAWDDTGVLLYSTLNHIKYTLLNGDNGIIKTLENTLYITKVQGNLIYCLNRQGQVETITIDPTEYRFKRALVNKNFGEVLRLIKNSTLVGQNIIGYLQKKGFPEVALHFVQDPETRFELALECSNLQVALEQAKILNNNQIWEKLGEEALLQGNIEIVEYIYQQLHHFDKLSFLYLYKGDDERLDKMSTIAQHRDDTSSLVQNTLYNNDIKKRCQVYIQNGMLPLAYTLAKSNGLNELAEQILQEANISEKDVELPELGDVVPLPKPIGEPVGNWPLKDSELSYFETALITGKIENLSINEDNLTTGAEGFESGATNIDENLGFDNNNNDDDDDDGEGGAFGGEDDAEAWDLDDELDIGDDDIVDENVPEFVTTENEIGDWLRNAKTPATYVAAGGFEQAASLLNKQIGVVNFEPLRTRFNQVYGASKLYLPGMDELPAMKTYIRHDNDEDNPRKFKPVVPGYDKLEELLSLGFKKFKANNLEEAITTFRKVIYTITVLNVDDEDDETKCHEILRLCREYILGLSIELERRKLPSSDVKRNLELAAYFTRAQLQPSHKLNALQVAMTQSFKNKNYASASYFAEELLKISNNSGPRAEQAMKLKNKADTIANDTIEINFDPFAEFDICCGSFTPIYKGEPFIKEALVGATYKPEFKGKLCNITDITAVGVPASGLRIKG
InterPro domains: - IPR006692: COPA/B, second beta-propeller domain (domain) [347-593]
- IPR047312: Coatomer subunit alpha, WD Associated Region (domain) [332-785]
- IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [110-286]
- IPR056176: COPA/B, TPR domain (domain) [634-776]
- IPR050844: Coatomer complex subunit (family) [6-338]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [3-557]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [1-328]
- IPR010714: Coatomer, alpha subunit, C-terminal (domain) [828-1219]
- IPR001680: WD40 repeat (repeat) [4-526]
- IPR019775: WD40 repeat, conserved site (conserved_site) [152-286]
- IPR016391: Coatomer subunit alpha (family) [1-1220]
Interaction partners: - Coatomer subunit epsilon
- Coatomer subunit zeta
- Coatomer subunit gamma
- Coatomer subunit beta'
- Coatomer subunit delta
- Coatomer subunit beta
- ADP-ribosylation factor GTPase-activating protein
- Dsl1p
- Vps53p
- Clathrin heavy chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0048475 (coated membrane), GO:0043227 (membrane-bounded organelle), GO:0005798 (Golgi-associated vesicle), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0030126 (COPI vesicle coat), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0030137 (COPI-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0030660 (Golgi-associated vesicle membrane), GO:0097708 (intracellular vesicle), GO:0030663 (COPI-coated vesicle membrane)