Protein: Rho guanine nucleotide exchange factor (GEF) 12a (E7FDV8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Membrane
Sequence: MSDTRSTVSDRTSSFLSRDHPPDKRPKSDKLPGTPTHEFDPTDVLVQKSGCVVADRRPESCGLVQRCVIIQKDENGFGLTVSGDNPVFVQLVKQDGAAMRAGVQTGDRIIKVNGTLVTQSNHVEVVKLIKSGSYVALTVLGRPPGLPQIPLPEVDVGLESPDVFGDPFITSPNSYNAAERTSSPLVSWEENSALHNQRMDSRRTGLKDQQDTQESPCLRNSEDGSWAEEDQYKRDFSPEAFWSGNSVPSVHRRFYPASPESQRDSNCSSPKSTPRDSFNSCPSPEVDYGSDLDSRFPSTVGSPRLVSEIIAAEDDDFDSEQEQVNGQCSCFQSIQLLKTRPAHLAAFLHHVISQFDPAPLLCYLYADLYKQTNSKETRRIFTDFLTFFIDRGANLKVTVPESISSELERRRPELIPEELHRQYIQTMQETLFPDVQRNLEDFRQKRSMGLTLADTELSRLDSEQLAVDRERACAESILSKIDDVLLTSQPTEEEKCSTIQYVIFMYMKHLGVRAKEQRNLESKRVRINFLPSKLRKSKTEKDGEEKLKKSRFPIRVPPRWPGRLDSVPSGRVGDSIKQRPQKQMSQPALGGSELIDAGRLRGSQSSEGSDLLHSPGLITSSPFSAPYSSPSDPSGRDSEFNMSPSAVVPRLSDGLQSGDPLDSIYPPCDYIPYNVDQLDEDRDGDRPPDVGTPKPSRRFEDLQSEDDQGSDVYSDVDPPNWQQLVGRDVLAGLTPHEIKRQEVINELFYTERAHVRMLKVLDKVFYQKLNRDNILPPADIKYIFTNLEEIIQLHVRIVDQMTAICKKNETSVIDHIGDELLSWFSSGEEEKIKQAVGTFCSNQPFALELIKSRQKKDQRFSSFMQEAESNRLCRRLQLKDIIPAEMQRFTKYPLLMDNIAKYTDESEEKDKVRRAAECCRQILNHVNQSVKESENKQRLEDYQRRLDLSSLKQSENPMISEFKNLDLTKRKMVHEGPLSWKINKDKTIELYTLLLEDILVLLQKQDERLILRCHSKNLAGTAETKHIFSPIIKLSTVLVRSVATDNRSFFVISMSKNGAQIYELMAQTVSEQRMWQRQITQRAEVMNTKPHSVIPLPQHDGDRDGVELSKFSKGSDRISTGSIQSAEKDGEFSPSAALRDCVPDTNPGEEDQVARAGRDASYQDSELLNGRETDSLSCSSKADEALKTLAALKQVLLTQLMAQDEGERLGRSAGSRLLRTTSLRTPVEHNSNRTPSRAQDYTSGDTGFYECPEDYAAYLVLEGFGGSGESSTDDDFQVGRKEPGLAHSCAADSGISLKFSSPSSGSTSRLSRQVLSHLRCLQANLNHLKEMETKYYNLLRQRPVGSAAEADESREKK
InterPro domains: - IPR001478: PDZ domain (domain) [67-144]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [949-1093]
- IPR000219: Dbl homology domain (domain) [739-929]
- IPR015212: Regulator of G protein signalling-like domain (domain) [327-513]
- IPR001849: Pleckstrin homology domain (domain) [971-1086]
- IPR036305: RGS domain superfamily (homologous_superfamily) [329-513]
- IPR044926: RGS, subdomain 2 (homologous_superfamily) [308-518]
- IPR036034: PDZ superfamily (homologous_superfamily) [59-146]
- IPR035899: Dbl homology (DH) domain superfamily (homologous_superfamily) [716-948]
- IPR041020: ARHGEF1-like, PH domain (domain) [957-1082]
Interaction partners: - G-protein alpha 13a
- G-protein alpha 12
- Rho-related GTP-binding protein RhoA-D
- Rho-related GTP-binding protein RhoA-A
- Rho-related GTP-binding protein RhoA-C
- Rho-related GTP-binding protein RhoA-B
- Muscle RAS oncogene homolog
- Ras-related protein M-Ras
- GTPase NRas
- RAS-related 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0001965 (G-protein alpha-subunit binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0003002 (regionalization), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0007166 (cell surface receptor signaling pathway), GO:0009855 (determination of bilateral symmetry), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0060972 (left/right pattern formation), GO:0072359 (circulatory system development), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048013 (ephrin receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0032153 (cell division site), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0043229 (intracellular organelle), GO:0032154 (cleavage furrow), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)