Protein: Transcription factor MafAa (Somite Maf1) (SMaf1) (A3KMR8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor, possibly involved in transcription regulation during lens development, including that of crystallin genes. Specifically binds to the alphaCE2 enhancer element of crystallin gene.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
Sequence: MATDLAMSAELPNSPLAIEYVNDFDLMKFEIKKEPPEADRYCHRLPPGSLSSTPISTPCSSVPSSPSFCAPSPGSQPGQNLVNGVNNNNNNSGNGNNNTQGSSGKPQMEDLYWIPNYQHHISPEALNLTPEDAVEALIGNAHHHHHHHHHQPYEGFRGQQYVGEDLSAATNGHHHPVHHHHHHHGHHAHARLEDRFSDEQLVSMTVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRYKRVQQRHMLESEKCTLQSQVEQLKQDVARLIKERDLYKEKYEKLASRAFNGGGNTRDPSSGNHVKTTSTDFFM
InterPro domains: - IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [224-280]
- IPR013592: Maf transcription factor, N-terminal (domain) [106-139]
- IPR024874: Transcription factor Maf family (family) [5-304]
- IPR004827: Basic-leucine zipper domain (domain) [219-286]
- IPR004826: Basic leucine zipper domain, Maf-type (domain) [196-286]
- IPR008917: Transcription factor, Skn-1-like, DNA-binding domain superfamily (homologous_superfamily) [196-236]
Interaction partners: - Pancreatic and duodenal homeobox 1.
- Alpha-tocopherol transfer protein-like
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0002682 (regulation of immune system process), GO:0050793 (regulation of developmental process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0002262 (myeloid cell homeostasis), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:1903706 (regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0034101 (erythrocyte homeostasis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048872 (homeostasis of number of cells), GO:0045637 (regulation of myeloid cell differentiation), GO:0030097 (hemopoiesis), GO:1902105 (regulation of leukocyte differentiation), GO:0030218 (erythrocyte differentiation), GO:0030099 (myeloid cell differentiation), GO:0060284 (regulation of cell development), GO:0061515 (myeloid cell development), GO:0048821 (erythrocyte development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)