Protein: CDPK-related kinase 3 (AtCRK3) (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase 4) (AtCK) (Q9ZUZ2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May play a role in signal transduction pathways that involve calcium as a second messenger (By similarity). Serine/threonine kinase that phosphorylates histone H3 an GLN1-1.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16472779}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Sequence: MGQCYGKVNQSKQNGEEEANTTTYVVSGDGNQIQPLTPVNYGRAKNTPARSSNPSPWPSPFPHGSASPLPSGVSPSPARTSTPRRFFRRPFPPPSPAKHIKASLIKRLGVKPKEGPIPEERGTEPEQSLDKSFGYGKNFGAKYELGKEVGRGHFGHTCSGRGKKGDIKDHPIAVKIISKAKMTTAIAIEDVRREVKLLKSLSGHKYLIKYYDACEDANNVYIVMELCDGGELLDRILARGGKYPEDDAKAIVVQILTVVSFCHLQGVVHRDLKPENFLFTSSREDSDLKLIDFGLSDFIRPDERLNDIVGSAYYVAPEVLHRSYSLEADIWSIGVITYILLCGSRPFWARTESGIFRTVLRTEPNYDDVPWPSCSSEGKDFVKRLLNKDYRKRMSAVQALTHPWLRDDSRVIPLDILIYKLVKAYLHATPLRRAALKALAKALTENELVYLRAQFMLLGPNKDGSVSLENFKTALMQNATDAMRESRVPEILHTMESLAYRKMYFEEFCAAAISIHQLEAVDAWEEIATAGFQHFETEGNRVITIEELARELNVGASAYGHLRDWVRSSDGKLSYLGFTKFLHGVTLRAAHARPR
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [134-421]
- IPR050205: Calcium-dependent Serine/Threonine Protein Kinases (family) [127-568]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [267-279]
- IPR011992: EF-hand domain pair (homologous_superfamily) [432-584]
- IPR002048: EF-hand domain (domain) [446-481]
- IPR017441: Protein kinase, ATP binding site (binding_site) [149-175]
- IPR000719: Protein kinase domain (domain) [143-405]
Interaction partners: - Cysteine-rich receptor-like protein kinase 1
- Cysteine-rich receptor-like protein kinase 21
- Putative cysteine-rich receptor-like protein kinase 16
- Cysteine-rich receptor-like protein kinase 41
- Cysteine-rich receptor-like protein kinase 46
- AP-3 complex subunit sigma
- Early nodulin-like protein 12
- Putative cysteine-rich receptor-like protein kinase 9
- Probable mediator of RNA polymerase II transcription subunit 26b
- Cysteine-rich receptor-like protein kinase 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0055044 (symplast), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0005911 (cell-cell junction)