Protein: Cell division protein FtsZ (O08398)
Organism: Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Function: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00909}. Note=Assembles at midcell at the inner surface of the cytoplasmic membrane. {ECO:0000255|HAMAP-Rule:MF_00909}.
Sequence: MGFDLDVEKKKENRNIPQANNLKIKVIGVGGAGNNAINRMIEIGIHGVEFVAVNTDLQVLEASNADVKIQIGENITRGLGAGGRPEIGEQAALESEEKIREVLQDTHMVFITAGFGGGTGTGASPVIAKIAKEMGILTVAIVTTPFYFEGPERLKKAIEGLKKLRKHVDTLIKISNNKLMEELPRDVKIKDAFLKADETLHQGVKGISELITKRGYINLDFADIESVMKDAGAAILGIGVGKGEHRAREAAKKAMESKLIEHPVENASSIVFNITAPSNIRMEEVHEAAMIIRQNSSEDADVKFGLIFDDEVPDDEIRVIFIATRFPDEDKILFPEGDIPAIYRYGLEGLL
InterPro domains: - IPR000158: Cell division protein FtsZ (family) [8-346]
- IPR020805: Cell division protein FtsZ, conserved site (conserved_site) [54-128]
- IPR036525: Tubulin/FtsZ, GTPase domain superfamily (homologous_superfamily) [22-216]
- IPR024757: Cell division protein FtsZ, C-terminal (domain) [232-325]
- IPR008280: Tubulin/FtsZ, C-terminal (homologous_superfamily) [215-329]
- IPR018316: Tubulin/FtsZ, 2-layer sandwich domain (domain) [217-335]
- IPR045061: Tubulin-like protein FtsZ/CetZ (family) [12-328]
- IPR003008: Tubulin/FtsZ, GTPase domain (domain) [23-243]
- IPR037103: Tubulin/FtsZ-like, C-terminal domain (homologous_superfamily) [217-335]
Interaction partners: - Cell division protein FtsA, putative
- Cell division protein FtsA, putative
- Probable septum site-determining protein MinC
- Protein translocase subunit SecA
- DNA gyrase subunit B
- UDP-N-acetylglucosamine--N-acetylmuramyl-
- General secretion pathway protein E
- Hypothetical protein
- Rod shape-determining protein RodA
- Probable branched-chain-amino-acid aminotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0050793 (regulation of developmental process), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0022402 (cell cycle process), GO:0032506 (cytokinetic process), GO:0000910 (cytokinesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0044837 (actomyosin contractile ring organization), GO:0030036 (actin cytoskeleton organization), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0000915 (actomyosin contractile ring assembly), GO:0000912 (assembly of actomyosin apparatus involved in cytokinesis), GO:0022604 (regulation of cell morphogenesis), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0030866 (cortical actin cytoskeleton organization), GO:0006996 (organelle organization), GO:0031032 (actomyosin structure organization), GO:0000281 (mitotic cytokinesis), GO:0022607 (cellular component assembly), GO:0008360 (regulation of cell shape), GO:0007010 (cytoskeleton organization), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)