Protein: Tyrosine-protein kinase (A0A8M3ASR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus
Sequence: MGFGRDLRNSHEGLMKLQDWELKLLETVKRFMTLRVKSDKEYASLLINISQQVDKHDNSSQIHYVSHVSKSWTHMVQQTEQLSKIMKCHAEELNSGPLHRLTMMIKDKQQVKKSYQSLHQQIESEMNKVTKSDLERLKCTYRQLTKDAVLAREKYKDAVLKGKETEKARERYDKATMKLHNLHNQYVLAVKSAQLHQEHYHEFALPLLLDSLQKMQEEMISALKGILEEYSEITSLLTDEIVKVHKEIHTSIDQIDPLSEYDNFIEVYKSPEAKEPNVEFDATLLDETENLQANEILWNNLTADSLQVMLKSTTEELLITQQNLHSKEDLMLDLEKKMEESTKAYEKKSDVVLFLSQRQFLEELRQTVQLLRCSEAKLMAQRELLEQKMQENEGKEPPPVVNYEEDARSVNSMVMHHLDKSKDRISKFDTLRHSIAGIIRSPKSVLGSSSFFDVIPTSEKPLGEQEWYHGAIPRTEAQELLKQQGDFLVRESHGKPGEYVLSVFSDGQRRHFIIQFADNQYRFEGTGFPTIPQLIDHHYTTKQVITKKSGVVLLNPVIKDKKWILNHEDVILGELLGKGNFGEVFKGTLRDKTPVAVKTCKEDLPQDLKIKFLSEARILKQYDHPNIVKLIGVCTQRQPIYIVMELVPGGDFLSFLRKKKEDLKTKQLVKFALDAAGGMAYLELKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDDGIYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSYGILLWETFSLGVCPYPGMTNQQAREQVEKGYRMSCPQKCPDEVYRVMQRCWEYKPENRPKFADIQKELAAVKKK
InterPro domains: - IPR001060: FCH domain (domain) [1-93]
- IPR031160: F-BAR domain (domain) [1-260]
- IPR016250: Tyrosine-protein kinase, Fes/Fps type (family) [1-827]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [453-588]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [572-821]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [552-819]
- IPR037452: Tyrosine-protein kinase Fer, F-BAR domain (domain) [5-239]
- IPR017441: Protein kinase, ATP binding site (binding_site) [576-598]
- IPR035849: Fes/Fps/Fer, SH2 domain (domain) [460-545]
- IPR000719: Protein kinase domain (domain) [570-824]
- IPR000980: SH2 domain (domain) [465-557]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [1-281]
- IPR050198: Non-receptor tyrosine kinases involved in cell signaling (family) [169-821]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [687-699]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [570-821]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048568 (embryonic organ development), GO:0060034 (notochord cell differentiation), GO:0007399 (nervous system development), GO:0048562 (embryonic organ morphogenesis), GO:0048570 (notochord morphogenesis), GO:0030903 (notochord development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)