Protein: Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (H3-clustered histone 2) (H3-clustered histone 3) (H3-clustered histone 4) (H3-clustered histone 6) (H3-clustered histone 7) (P84228)
Organism: Mus musculus (Mouse)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Sequence: MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [2-136]
- IPR000164: Histone H3/CENP-A (family) [1-136]
- IPR007125: Histone H2A/H2B/H3 (domain) [7-132]
Interaction partners: - Histone H4
- Chromobox protein homolog 5
- WD repeat-containing protein 5
- DNA
- V
- Chromobox protein homolog 3
- Bromodomain-containing protein 4
- Histone H3.3
- Histone H2B type 2-B
- DNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0040007 (growth), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007566 (embryo implantation), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0071840 (cellular component organization or biogenesis), GO:0009566 (fertilization), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009892 (negative regulation of metabolic process), GO:0044706 (multi-multicellular organism process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0044703 (multi-organism reproductive process), GO:0035264 (multicellular organism growth), GO:0001503 (ossification), GO:0021700 (developmental maturation), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0001649 (osteoblast differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048515 (spermatid differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0007283 (spermatogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0071695 (anatomical structure maturation), GO:0061061 (muscle structure development), GO:0007565 (female pregnancy), GO:0048469 (cell maturation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0009994 (oocyte differentiation), GO:0007548 (sex differentiation), GO:0001556 (oocyte maturation), GO:0046661 (male sex differentiation), GO:0051128 (regulation of cellular component organization), GO:0007338 (single fertilization), GO:0061458 (reproductive system development), GO:0043254 (regulation of protein-containing complex assembly), GO:0048477 (oogenesis), GO:0008406 (gonad development), GO:0006325 (chromatin organization), GO:0046546 (development of primary male sexual characteristics), GO:0007286 (spermatid development), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0010639 (negative regulation of organelle organization), GO:0042692 (muscle cell differentiation), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0033043 (regulation of organelle organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0010629 (negative regulation of gene expression), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0031047 (RNA-mediated gene silencing), GO:0051276 (chromosome organization), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0008584 (male gonad development), GO:0006997 (nucleus organization), GO:0045814 (negative regulation of gene expression, epigenetic), GO:2001251 (negative regulation of chromosome organization), GO:0033044 (regulation of chromosome organization), GO:0031048 (RNA-mediated heterochromatin formation), GO:0031507 (heterochromatin formation), GO:0034508 (centromere complex assembly), GO:0070828 (heterochromatin organization), GO:0032200 (telomere organization), GO:0065004 (protein-DNA complex assembly), GO:0031508 (pericentric heterochromatin formation), GO:0031509 (subtelomeric heterochromatin formation), GO:0140719 (constitutive heterochromatin formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)