Protein: RapA guanosine triphosphatase-activating protein B (Q54SS8)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Mediates the deactivation of rap1 during multicellular development and is required for normal morphogenesis. Also required for the correct patterning of specific subtypes of prestalk cells.
Sequence: MFSHCEGYRIEGGVTDGETNWNNNFNQNNNNNDNNKVMASIYKQQFYGKPHKTFMSLSSPNGPILVCIKKVGNSSDDFYLLVCTEKGFEEVRANKDSLQKSKTTRSFLKMRPTSLNVITSVRPELTKVPLCKVTDKSIQEELVKVCEPEFNKVIKSALLYCKESQRDDNDMLKNISSNVSQEYNDFLNFLGEKVELKDFSKFNGGLDIKNNSHGTHSIYSQINDVEVMYHVATMLPFFPSDPKQSERRKLISLDRVVIIFNDGSKPMSPNCIKSKSTQIIILIQPIKNFVGNSKTTIGISNDENRVVGEQPSPSLTTTTTTTTTTSPTINSNSPTPSNKIKYRVSISNRDEVPNYGPPLPDPPIFEKDDSFRNFLYQKMVGGAASLRNTPAFTSKNSEKASALINVISKYSTKGMEQI
InterPro domains: - IPR035974: Rap/Ran-GAP superfamily (homologous_superfamily) [39-409]
- IPR000331: Rap/Ran-GAP domain (domain) [142-407]
- IPR050989: Rap1/Ran GTPase-activating (family) [26-412]
Interaction partners: - Oxidation resistance protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0007163 (establishment or maintenance of cell polarity), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051129 (negative regulation of cellular component organization), GO:1901698 (response to nitrogen compound), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0010033 (response to organic substance), GO:0090066 (regulation of anatomical structure size), GO:0031589 (cell-substrate adhesion), GO:0044087 (regulation of cellular component biogenesis), GO:0031333 (negative regulation of protein-containing complex assembly), GO:0046683 (response to organophosphorus), GO:0032535 (regulation of cellular component size), GO:1902903 (regulation of supramolecular fiber organization), GO:0051591 (response to cAMP), GO:0010639 (negative regulation of organelle organization), GO:0043254 (regulation of protein-containing complex assembly), GO:0010243 (response to organonitrogen compound), GO:0051336 (regulation of hydrolase activity), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0014070 (response to organic cyclic compound), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0043085 (positive regulation of catalytic activity), GO:0032272 (negative regulation of protein polymerization), GO:0043087 (regulation of GTPase activity), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:0032271 (regulation of protein polymerization), GO:0051345 (positive regulation of hydrolase activity), GO:0030837 (negative regulation of actin filament polymerization), GO:0110053 (regulation of actin filament organization), GO:0014074 (response to purine-containing compound), GO:0030832 (regulation of actin filament length), GO:0043519 (regulation of myosin II filament organization), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0030833 (regulation of actin filament polymerization), GO:0043547 (positive regulation of GTPase activity), GO:0090630 (activation of GTPase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005622 (intracellular anatomical structure), GO:0005938 (cell cortex)