Protein: H/ACA ribonucleoprotein complex non-core subunit NAF1 (Q3UMQ8)
Organism: Mus musculus (Mouse)
Function: RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P53919}. Nucleus {ECO:0000250|UniProtKB:P53919}. Note=Shuttles between the cytoplasm and the nucleus. Absent from the nucleolus (By similarity). {ECO:0000250|UniProtKB:P53919}.
Sequence: MEVVEAAAQLQTLKFGGSGQGSAAPQPPEDRREAPPPGVQPPPPAPSGRPPPPPAPSSDPGGRPPPPPAPNWDAGGRPPPPPAPNSDPPPGGAWVTGRNAAEPPPVLQASDSSDSDSDSETDSDSSSSSSSSSSSSSSCVSFPPVLSDGDEDFQLEKENKNFPLKTKDELLLNELPSVEELTVILPEDIALKPLGKVSSIIEQLVIIESVTNIPPVNEDTVIFKSDRQAAGKIFEIFGPVAHPFYVLRFNSSDHIESKGIKINDTMYFAPSMKDFTQYIFTEKLKQDRGSDASWKNDQEPPPEVLDFSDDEKEKEAKQRKKSQIQGRKKLKSELNESGEDFGEVHENWNAYSSSEHSKGYHHREFSRGFARGRYSRRSHGRPPPQQYYNSDHMASQESLGFTPQRQDNPVMPHYPFPPPMFDMHNFPLPPPPPPPPPPPPSMGWAAPSMASHPVLNLPYSMPPPPLPPPPPPPPPSPGENNSSHFGPYF
InterPro domains: - IPR038664: H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain (homologous_superfamily) [162-269]
- IPR040309: H/ACA ribonucleoprotein complex non-core subunit Naf1 (family) [110-473]
- IPR009000: Translation protein, beta-barrel domain superfamily (homologous_superfamily) [191-268]
- IPR007504: H/ACA ribonucleoprotein complex, subunit Gar1/Naf1 (family) [192-279]
Interaction partners: - H/ACA ribonucleoprotein complex subunit DKC1
- H/ACA ribonucleoprotein complex subunit 3
- H/ACA ribonucleoprotein complex subunit 2
- H/ACA ribonucleoprotein complex subunit 1
- Nucleolar and coiled-body phosphoprotein 1
- Pseudouridylate synthase TRUB1
- Nucleolar protein 58
- U3 small nucleolar RNA-interacting protein 2
- Seminal vesicle secretory protein 3B
- Seminal vesicle secretory protein 3A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006325 (chromatin organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization), GO:0140719 (constitutive heterochromatin formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)