Protein: Transcription factor AP-2-epsilon (AP-2-epsilon) (Q6P0E7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q6VUP9}.
Sequence: MLVHSYSSMERADGLSSSSPGGRLSQLNQAAYSSAPPLCHTPASDFQPPYFPPPYPQSSLSYSQSQDGGYPHLPEPYPSLNSLHQHQQAAWHSQRSRSEDAGLLSQPHRALSLDPRREYPGVPRLLTHGLGDGAAALGDGPLGMHAVHHGLDDIQGLEEASALGILDHSVIKKVPLPSKLNGSTISALSLSKEGLGLGGVSNPAEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLAPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTALVEGEAVHLARDFGYVCETEFPARATAEYLCRQTEPDQLPTRRSMLLATKEICKEFVDLMSQDRSPLGASRPTPCLEPGVQSSLTHFSLLTHGFGTPALCAALSAFQSYLLEALKLLDKGENGGKNHHDKELKHRK
InterPro domains: - IPR004979: Transcription factor AP-2 (family) [28-417]
- IPR013854: Transcription factor AP-2, C-terminal (domain) [207-398]
Interaction partners: - Odd-paired-like)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0048066 (developmental pigmentation), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0001708 (cell fate specification), GO:0060255 (regulation of macromolecule metabolic process), GO:0060788 (ectodermal placode formation), GO:0060041 (retina development in camera-type eye), GO:0035295 (tube development), GO:0045165 (cell fate commitment), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0060322 (head development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0050931 (pigment cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0072006 (nephron development), GO:0080090 (regulation of primary metabolic process), GO:0014029 (neural crest formation), GO:0048839 (inner ear development), GO:0071696 (ectodermal placode development), GO:1904888 (cranial skeletal system development), GO:0071697 (ectodermal placode morphogenesis), GO:0035239 (tube morphogenesis), GO:0072001 (renal system development), GO:0014034 (neural crest cell fate commitment), GO:0071599 (otic vesicle development), GO:0051216 (cartilage development), GO:0048864 (stem cell development), GO:0048705 (skeletal system morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0072009 (nephron epithelium development), GO:0042472 (inner ear morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0061448 (connective tissue development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0061005 (cell differentiation involved in kidney development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0030318 (melanocyte differentiation), GO:0002009 (morphogenesis of an epithelium), GO:0060485 (mesenchyme development), GO:0043049 (otic placode formation), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0072175 (epithelial tube formation), GO:0007420 (brain development), GO:0048866 (stem cell fate specification), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0048568 (embryonic organ development), GO:0061326 (renal tubule development), GO:0007399 (nervous system development), GO:0048865 (stem cell fate commitment), GO:0001501 (skeletal system development), GO:0007422 (peripheral nervous system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0007417 (central nervous system development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0039019 (pronephric nephron development), GO:0051252 (regulation of RNA metabolic process), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0030182 (neuron differentiation), GO:0009792 (embryo development ending in birth or egg hatching), GO:0014033 (neural crest cell differentiation), GO:0072080 (nephron tubule development), GO:0048793 (pronephros development), GO:0043009 (chordate embryonic development), GO:0001837 (epithelial to mesenchymal transition), GO:0001654 (eye development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0035850 (epithelial cell differentiation involved in kidney development), GO:2001141 (regulation of RNA biosynthetic process), GO:0072073 (kidney epithelium development), GO:0043583 (ear development), GO:0006355 (regulation of DNA-templated transcription), GO:0030916 (otic vesicle formation), GO:0150063 (visual system development), GO:0048706 (embryonic skeletal system development), GO:0071600 (otic vesicle morphogenesis), GO:0042471 (ear morphogenesis), GO:0048699 (generation of neurons), GO:0039020 (pronephric nephron tubule development), GO:0014032 (neural crest cell development), GO:0043010 (camera-type eye development), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)