Protein: Liver X nuclear receptor alpha variant 1 (F1D8N1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU004334}.
Sequence: MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
InterPro domains: - IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [205-447]
- IPR023257: Liver X receptor (family) [85-433]
- IPR001723: Nuclear hormone receptor (family) [159-423]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [209-447]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [95-170]
- IPR050234: Nuclear hormone receptor family NR1 subfamily (family) [74-444]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [91-192]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0036094 (small molecule binding), GO:0003700 (DNA-binding transcription factor activity), GO:0008289 (lipid binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0004879 (nuclear receptor activity), GO:0003676 (nucleic acid binding), GO:0098531 (ligand-activated transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0015485 (cholesterol binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0032934 (sterol binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:0003690 (double-stranded DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:1905953 (negative regulation of lipid localization), GO:1905954 (positive regulation of lipid localization), GO:0042221 (response to chemical), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051050 (positive regulation of transport), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0051051 (negative regulation of transport), GO:0042752 (regulation of circadian rhythm), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0055088 (lipid homeostasis), GO:0051129 (negative regulation of cellular component organization), GO:0043207 (response to external biotic stimulus), GO:0032370 (positive regulation of lipid transport), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0010883 (regulation of lipid storage), GO:0006725 (cellular aromatic compound metabolic process), GO:0009725 (response to hormone), GO:1901360 (organic cyclic compound metabolic process), GO:0009755 (hormone-mediated signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010888 (negative regulation of lipid storage), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:1905952 (regulation of lipid localization), GO:0046483 (heterocycle metabolic process), GO:0032409 (regulation of transporter activity), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0006139 (nucleobase-containing compound metabolic process), GO:0045806 (negative regulation of endocytosis), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0032411 (positive regulation of transporter activity), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0032369 (negative regulation of lipid transport), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0045834 (positive regulation of lipid metabolic process), GO:0031347 (regulation of defense response), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0045089 (positive regulation of innate immune response), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0048545 (response to steroid hormone), GO:0002237 (response to molecule of bacterial origin), GO:0010743 (regulation of macrophage derived foam cell differentiation), GO:0032368 (regulation of lipid transport), GO:0010468 (regulation of gene expression), GO:0090208 (positive regulation of triglyceride metabolic process), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0055092 (sterol homeostasis), GO:0090207 (regulation of triglyceride metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0010467 (gene expression), GO:0030100 (regulation of endocytosis), GO:0010565 (regulation of cellular ketone metabolic process), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0019438 (aromatic compound biosynthetic process), GO:0046889 (positive regulation of lipid biosynthetic process), GO:0062207 (regulation of pattern recognition receptor signaling pathway), GO:0032373 (positive regulation of sterol transport), GO:0062208 (positive regulation of pattern recognition receptor signaling pathway), GO:0046890 (regulation of lipid biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0016192 (vesicle-mediated transport), GO:0014070 (response to organic cyclic compound), GO:0019216 (regulation of lipid metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0071222 (cellular response to lipopolysaccharide), GO:0016070 (RNA metabolic process), GO:0006909 (phagocytosis), GO:0032371 (regulation of sterol transport), GO:0042304 (regulation of fatty acid biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0032570 (response to progesterone), GO:0060191 (regulation of lipase activity), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0051345 (positive regulation of hydrolase activity), GO:0010866 (regulation of triglyceride biosynthetic process), GO:0010867 (positive regulation of triglyceride biosynthetic process), GO:0048548 (regulation of pinocytosis), GO:0019217 (regulation of fatty acid metabolic process), GO:0034143 (regulation of toll-like receptor 4 signaling pathway), GO:0006355 (regulation of DNA-templated transcription), GO:0032376 (positive regulation of cholesterol transport), GO:0071396 (cellular response to lipid), GO:0045723 (positive regulation of fatty acid biosynthetic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0042632 (cholesterol homeostasis), GO:0043277 (apoptotic cell clearance), GO:0016071 (mRNA metabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0060193 (positive regulation of lipase activity), GO:0032374 (regulation of cholesterol transport), GO:0051004 (regulation of lipoprotein lipase activity), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0010875 (positive regulation of cholesterol efflux), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0010874 (regulation of cholesterol efflux), GO:0006366 (transcription by RNA polymerase II), GO:0009299 (mRNA transcription), GO:0042789 (mRNA transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0005829 (cytosol), GO:0043235 (receptor complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0005667 (transcription regulator complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0090575 (RNA polymerase II transcription regulator complex), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)