Protein: C-X-C chemokine receptor type 2 (High affinity interleukin-8 receptor B) (C9JW47)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDM
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [65-200]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [50-198]
- IPR000174: CXC chemokine receptor 1/2 (family) [35-133]
- IPR050119: C-C chemokine receptor type 1-9-like (family) [21-199]
- IPR000057: CXC chemokine receptor 2 (family) [5-47]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0019955 (cytokine binding), GO:0140375 (immune receptor activity), GO:0019956 (chemokine binding), GO:0004896 (cytokine receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0004950 (chemokine receptor activity), GO:0001637 (G protein-coupled chemoattractant receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0042330 (taxis), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0006955 (immune response), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0032103 (positive regulation of response to external stimulus), GO:0044093 (positive regulation of molecular function), GO:2000145 (regulation of cell motility), GO:0050920 (regulation of chemotaxis), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0080090 (regulation of primary metabolic process), GO:0006935 (chemotaxis), GO:0050921 (positive regulation of chemotaxis), GO:0008284 (positive regulation of cell population proliferation), GO:0016477 (cell migration), GO:0060326 (cell chemotaxis), GO:0034097 (response to cytokine), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0030334 (regulation of cell migration), GO:0010468 (regulation of gene expression), GO:0060326 (cell chemotaxis), GO:0072359 (circulatory system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0030335 (positive regulation of cell migration), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0019221 (cytokine-mediated signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0001938 (positive regulation of endothelial cell proliferation), GO:0051347 (positive regulation of transferase activity), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0071345 (cellular response to cytokine stimulus), GO:0043087 (regulation of GTPase activity), GO:0043549 (regulation of kinase activity), GO:0060191 (regulation of lipase activity), GO:1990868 (response to chemokine), GO:0043410 (positive regulation of MAPK cascade), GO:0051345 (positive regulation of hydrolase activity), GO:0070098 (chemokine-mediated signaling pathway), GO:0031401 (positive regulation of protein modification process), GO:1990869 (cellular response to chemokine), GO:0010517 (regulation of phospholipase activity), GO:0043547 (positive regulation of GTPase activity), GO:0045859 (regulation of protein kinase activity), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0043406 (positive regulation of MAP kinase activity), GO:0001934 (positive regulation of protein phosphorylation), GO:0060193 (positive regulation of lipase activity), GO:0010518 (positive regulation of phospholipase activity), GO:1900274 (regulation of phospholipase C activity), GO:0010863 (positive regulation of phospholipase C activity), GO:0007202 (activation of phospholipase C activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005654 (nucleoplasm), GO:0071944 (cell periphery), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)