Protein: STIL centriolar assembly protein (A0A0A0MR87)
Organism: Homo sapiens (Human)
Sequence: MEPIYPFARPQMNTRFPSSRMVPFHFPPSKCALWNPTPTGDFIYLHLSYYRNPKLVVTEKTIRLAYRHAKQNKKNSSCFLLGSLTADEDEEGVTLTVDRFDPGREVPECLEITPTASLPGDFLIPCKVHTQELCSREMIVHSVDDFSSALKALQCHICSKDSLDCALARNLSSNLNISQVQGTYKYGYLTMDETRKLLLLLESDPKVYSLPLVGIWLSGITHIYSPQVWACCLRYIFNSSVQERVFSESGNFIIVLYSMTHKEPEFYECFPCDGKIPDFRFQLLTSKETLHLFKNVEPPDKNPIRCELSAESQNAETEFFSKASKNFSIKRSSQKLSSGKMPIHDHDSGVEDEDFSPRPIPSPHPVSQKISKIQPSVPELSLVLDGNFIESNPLPTPLEMVNNENPPLINHLEHLKPLQPQLYDEKHSPEVEAGEPSLRGIPNQLNQDKPALLRHCKVRQPPAYKKGNPHTRNSIKPSSHNGPSHDIFEKLQTVSAGNVQNEEYPIRPSTLNSRQSSLAPQSQPHDFVFSPHNSGRPMELQIPTPPLPSYCSTNVCRCCQHHSHIQYSPLNSWQGANTVGSIQDVQSEALQKHSLFHPSGCPALYCNAFCSSSSPIALRPQGDMGSCSPHSNIEPSPVARPPSHMDLCNPQPCTVCMHTPKTESDNGMMGLSPDAYRFLTEQDRQLRLLQAQIQRLLEAQSLMPCSPKTTAVEDTVQAGRQMELVSVEAQSSPGLHMRKGVSIAVSTGASLFWNAAGEDQEPDSQMKQDDTKISSEDMNFSVDINNEVTSLPGSASSLKAVDIPSFEESNIAVEEEFNQPLSVSNSSSLVVRKEPDVPVFFPSGQLAESVSMCLQTGPTGGASNNSETSEEPKIEHVMQPLLHQPSDNQKIYQDLLGQVNHLLNSSSKETEQPSTKAVIISHECTRTQNVYHTKKKTHHSRLVDKDCVLNATLKQLRSLGVKIDSPTKVKKNAHNVDHASVLACISPEAVISGLNCMSFANVGMSGLSPNGVDLSMEANAIALKYLNENQLSQLSVTRSNQNNCDPFSLLHINTDRSTVGLSLISPNNMSFATKKYMKRYGLLQSSDNSEDEEEPPDNADSKSEYLLNQNLRSIPEQLGGQKEPSKNDHEIINCSNCESVGTNADTPVLRNITNEVLQTKAKQQLTEKPAFLVKNLKPSPAVNLRTGKAEFTQHPEKENEGDITIFPESLQPSETLKQMNSMNSVGTFLDVKRLRQLPKLF
InterPro domains: - IPR057731: STIL, N-terminal domain (domain) [33-328]
- IPR057655: STIL, coiled coil region (domain) [673-701]
- IPR026123: STIL (family) [166-1241]
- IPR058559: STIL, proline-rich motif (conserved_site) [342-388]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0008285 (negative regulation of cell population proliferation), GO:0060255 (regulation of macromolecule metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0051726 (regulation of cell cycle), GO:0042127 (regulation of cell population proliferation), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045786 (negative regulation of cell cycle), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0010562 (positive regulation of phosphorus metabolic process), GO:1901989 (positive regulation of cell cycle phase transition), GO:0051246 (regulation of protein metabolic process), GO:0042770 (signal transduction in response to DNA damage), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0072331 (signal transduction by p53 class mediator), GO:0022607 (cellular component assembly), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0051174 (regulation of phosphorus metabolic process), GO:1901988 (negative regulation of cell cycle phase transition), GO:0070925 (organelle assembly), GO:0031570 (DNA integrity checkpoint signaling), GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0031399 (regulation of protein modification process), GO:0065003 (protein-containing complex assembly), GO:0045937 (positive regulation of phosphate metabolic process), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0000819 (sister chromatid segregation), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902807 (negative regulation of cell cycle G1/S phase transition), GO:0031401 (positive regulation of protein modification process), GO:0000077 (DNA damage checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:0001932 (regulation of protein phosphorylation), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0000280 (nuclear division), GO:0033674 (positive regulation of kinase activity), GO:0007095 (mitotic G2 DNA damage checkpoint signaling), GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle), GO:0045859 (regulation of protein kinase activity), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:0042327 (positive regulation of phosphorylation), GO:0140694 (non-membrane-bounded organelle assembly), GO:0065004 (protein-DNA complex assembly), GO:0001934 (positive regulation of protein phosphorylation), GO:0042325 (regulation of phosphorylation), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0000922 (spindle pole), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005814 (centriole), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005819 (spindle), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)