Protein: Outer kinetochore KNL1 complex subunit ZWINT (SNAP25-interacting protein 30) (Scoilin) (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1) (Q8VIL3)
Organism: Rattus norvegicus (Rat)
Function: Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity).
Subcellular location: Nucleus {ECO:0000250|UniProtKB:O95229}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O95229}. Note=Localizes to kinetochores from late prophase to anaphase (By similarity). Localizes to kinetochores both during mitosis and meiosis (By similarity). {ECO:0000250|UniProtKB:O95229, ECO:0000250|UniProtKB:Q9CQU5}.
Sequence: MADAEKNAVAEKNAVAEENAVAEENAVADKNATKEVLAEAASVLEPVGLPEEAELPAKIMEEFMRNSRKKDKLLCSQLQVVNFLQTFLAQEDNTDQNPDALASEDTSRQKATETKEQWKELKATYMDHVDVIKCALSEALPQVKEAHRKYTELQKAFEQLEAKKRVLEEKLQLAQKQWVLQQKRLQNLTKISAEVKRRRKRALEKLDGSHQELETLKQQAGQEQEKLQRNQSYLQLLCSLQNKLVISESKADDKDVKGPALPPKSP
InterPro domains: - IPR029092: ZW10 interactor (family) [1-255]
Interaction partners: - Kinetochore protein NDC80
- DSN1, MIND kinetochore complex component, homolog
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Cell division cycle protein 20 homolog
- Kinetochore protein Nuf2
- Mitotic checkpoint serine/threonine-protein kinase BUB1
- Kinetochore protein Spc24
- NSL1 component of MIS12 kinetochore complex
- Protein zwilch
- Centromere/kinetochore protein zw10 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033036 (macromolecule localization), GO:0001666 (response to hypoxia), GO:0010035 (response to inorganic substance), GO:0046907 (intracellular transport), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0006810 (transport), GO:0006970 (response to osmotic stress), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0045184 (establishment of protein localization), GO:0071456 (cellular response to hypoxia), GO:0010038 (response to metal ion), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0071453 (cellular response to oxygen levels), GO:0015031 (protein transport), GO:0036293 (response to decreased oxygen levels), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0036294 (cellular response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0099080 (supramolecular complex), GO:0043229 (intracellular organelle), GO:0000775 (chromosome, centromeric region), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0000779 (condensed chromosome, centromeric region), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0000793 (condensed chromosome)