Protein: General negative regulator of transcription subunit 3 (Q5AD56)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Required for yeast cell adherence to silicone substrate, but nor required not required for buccal epithelial cell adherence or virulence in mouse systemic infection
Subcellular location: Cytoplasm. Nucleus
Sequence: MSNRKLQKEIDIIFKKIQEGLQDFDYHYERYESIQNTEDDSDNQREKEKLANDLKKEIKKLQKFREQIKHWLQNDTVHTLGPVGTSYESKLAENKSLIEDSMETYKLVEKQSKLKTFSNQSIMMTFMDSTNGDDDDDDDDSDDDELFSGSDEDEEDEYSDLPEDAVNAIHFFKDSILQLREQTHKLDHEYEKLAAKKLRKNNLATIEAKKEKIQSTIGNNKFHQKKLKKLLRQLTSGVVTEFNLIWLLKDDLNKYLESNGDYEFTRETELYDDIFNQIAAVEEDYSEIHEDNHDHSHSHLEKTSTANGTHHESATTTATAAKNSSVTTRTSPSPILTKANGHIKELSVESGSPTTSRSKLSKIHTNTSQSSTHSNTSSSTHAQAPRQSPELTSPAIVKTLRPATAPSKPVGTLKWSAAAAAAIPDVQEKPELVETESNGSSVHKTVSKDQYEEKINYQSPAPTQQQQQPQTSVESKTLSTTQSLASSITDNINLDKYKEVIKNSNLTKTELGLFSDMNLARVPPGIQDLVISFASKRNNDNFKVLVDSTEFNQFALPLHKPYLPEIVQPSYYSQYTSTSFKHPTPLVKFQSYWNQVRANFGFQKLMDEIKSLTLQNNADNLPIIAELTFVLFYGFYYGVTPAENLIAESYLFELGWKPYKNQSEDGSNNLSTGSISLSDINGSKSKSNRSSNYYFWFKRVKLISRGEDMGQPSNIEFGDYQVFDLSFWEIFVKYGFKFDYNFCQMEPSKTLF
InterPro domains: - IPR007207: CCR4-Not complex component, Not N-terminal domain (domain) [2-276]
- IPR040168: Not2/Not3/Not5 (family) [32-746]
Interaction partners: - CCR4-NOT core ubiquitin-protein ligase subunit
- General negative regulator of transcription subunit
- General negative regulator of transcription subunit 1
- CCR4-NOT core subunit
- CCR4-NOT core subunit
- CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4
- CCR4-NOT core DEDD family RNase subunit
- ATP-dependent RNA helicase DHH1
- Coupling of ubiquitin conjugation to ER degradation protein 1
- CCR4-NOT core subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0040007 (growth), GO:0009987 (cellular process), GO:0030447 (filamentous growth), GO:0007155 (cell adhesion), GO:0009607 (response to biotic stimulus), GO:0098609 (cell-cell adhesion), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0035770 (ribonucleoprotein granule), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0010494 (cytoplasmic stress granule), GO:0043232 (intracellular non-membrane-bounded organelle)