Protein: Ran-binding protein 9 (RanBP9) (B-cell antigen receptor Ig beta-associated protein 1) (IBAP-1) (Ran-binding protein M) (RanBPM) (P69566)
Organism: Mus musculus (Mouse)
Function: May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:18710924}. Cell membrane {ECO:0000305|PubMed:18710924}; Peripheral membrane protein {ECO:0000305|PubMed:18710924}; Cytoplasmic side {ECO:0000305|PubMed:18710924}. Nucleus {ECO:0000269|PubMed:18710924}. Note=Predominantly cytoplasmic (PubMed:18710924). A phosphorylated form is associated with the plasma membrane (By similarity). Perinuclear in spermatids (PubMed:14648869). {ECO:0000250|UniProtKB:Q96S59, ECO:0000269|PubMed:14648869, ECO:0000269|PubMed:18710924}.
Sequence: MSGQPPPPPPQQQPPPPPPPASAAAPATAPPGLAVGPGPAAGVPVPGLAAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMSIHSLAPGKSSTAHFSGFESCSNGVISNKAHQSYCHSKHQLSSLTVPELNSLNVSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDCSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRECGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGVGSCAFATVEDYLH
InterPro domains: - IPR013144: CRA domain (domain) [539-641]
- IPR006595: CTLH, C-terminal LisH motif (domain) [328-385]
- IPR003877: SPRY domain (domain) [137-258]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [84-271]
- IPR001870: B30.2/SPRY domain (domain) [72-259]
- IPR024964: CTLH/CRA C-terminal to LisH motif domain (domain) [329-632]
- IPR043136: B30.2/SPRY domain superfamily (homologous_superfamily) [66-275]
- IPR035782: Ran binding protein 9/10, SPRY domain (domain) [114-256]
- IPR006594: LIS1 homology motif (conserved_site) [290-322]
- IPR050618: Ubiquitination and Signaling Pathway Regulator (family) [69-639]
Interaction partners: - Ran-binding protein 10
- WD repeat-containing protein 26
- Muskelin
- Neural cell adhesion molecule L1
- Glucose-induced degradation protein 8 homolog
- Armadillo repeat-containing protein 8
- E3 ubiquitin-protein ligase RMND5A
- Glucose-induced degradation protein 4 homolog
- ATP-dependent RNA helicase DDX4
- E3 ubiquitin-protein transferase MAEA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0019899 (enzyme binding), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0008092 (cytoskeletal protein binding), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0051020 (GTPase binding), GO:0030695 (GTPase regulator activity), GO:0015631 (tubulin binding), GO:0031267 (small GTPase binding), GO:0048487 (beta-tubulin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007017 (microtubule-based process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)