Protein: Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Q95RB1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSMSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRFKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDGTEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCEQNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRSIALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLAGIPPPSAKPNDYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAAPYGNATSTALSSSGVNLDSISIPPPPGQVPYPSQDASRMGAVKK
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [224-309]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [233-303]
- IPR039171: Pre-mRNA-splicing factor Cwc2/Slt11 (family) [1-415]
- IPR048995: STL11/RBM22-like, N-terminal domain (domain) [21-108]
- IPR036855: Zinc finger, CCCH-type superfamily (homologous_superfamily) [162-184]
- IPR000504: RNA recognition motif domain (domain) [232-305]
- IPR000571: Zinc finger, CCCH-type (domain) [159-186]
- IPR057674: RBM22, CCCH zinc finger domain (domain) [159-186]
Interaction partners: - Pre-mRNA-splicing factor syf1 homolog
- Protein BUD31 homolog
- Protein crooked neck
- Puff-specific protein Bx42
- Pleiotropic regulator 1
- 116 kDa U5 small nuclear ribonucleoprotein component
- Cell division cycle 5, isoform A
- Pre-mRNA-processing factor 17
- Pre-mRNA-processing factor 19
- RNA helicase aquarius
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0016070 (RNA metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005681 (spliceosomal complex), GO:0043229 (intracellular organelle), GO:0071013 (catalytic step 2 spliceosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0071011 (precatalytic spliceosome), GO:0005634 (nucleus)