Protein: Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) (P62306)
Organism: Homo sapiens (Human)
Function: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
Sequence: MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLGEVLIRCNNVLYIRGVEEEEEDGEMRE
InterPro domains: - IPR016487: Sm-like protein Lsm6/SmF (family) [1-79]
- IPR047575: Sm domain (domain) [6-78]
- IPR010920: LSM domain superfamily (homologous_superfamily) [7-77]
- IPR034100: Small nuclear ribonucleoprotein F (family) [6-74]
- IPR001163: Sm domain, eukaryotic/archaea-type (domain) [9-74]
Interaction partners: - Cell division cycle 5-like protein
- Pre-mRNA-splicing factor RBM22
- Pre-mRNA-processing factor 6
- Small nuclear ribonucleoprotein-associated proteins B and B'
- Small nuclear ribonucleoprotein E
- Small nuclear ribonucleoprotein Sm D3
- U2 small nuclear ribonucleoprotein B''
- U4/U6.U5 tri-snRNP-associated protein 1
- Protein BUD31 homolog
- U7 snRNA-associated Sm-like protein LSm10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0120114 (Sm-like protein family complex), GO:0005654 (nucleoplasm), GO:0120115 (Lsm2-8 complex), GO:0005681 (spliceosomal complex), GO:0043233 (organelle lumen), GO:0030532 (small nuclear ribonucleoprotein complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0097525 (spliceosomal snRNP complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0071011 (precatalytic spliceosome), GO:0005684 (U2-type spliceosomal complex), GO:0031981 (nuclear lumen), GO:0097526 (spliceosomal tri-snRNP complex), GO:0071005 (U2-type precatalytic spliceosome), GO:0005634 (nucleus), GO:0046540 (U4/U6 x U5 tri-snRNP complex)