Protein: Mitochondrial metalloendopeptidase OMA1 (Q9FLI5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protease that is part of the quality control system in the inner membrane of mitochondria (By similarity). Metalloendopeptidase that modulates the oxidative phosphorylation (OXPHOS) system and plant growth. Involved in tolerance mechanisms to heat, osmotic and oxidative stresses
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein
Sequence: MKPSLKRRLLLLSRKFAKASIRKLLRQSSFSSHEFLLQAPFPAMSWYRRTKLVFDSLRRNINPKILPRSHVTSRINNPIGSSNPSAKFSSISSREVGLRSWTSLGRNTNRIAYNPFLSQPKRYYYVDRYQVRHFKPRGPGRWFQNPRTVFTVVLVGSVGLITLIVGNTETIPYTKRTHFILLSKPMEKLLGETQFEQIKKTYQGKILPATHPESIRVRLIAKEVIDALQRGLSNERVWSDLGYASTESSLGGGSDKGVKEMEMAMSGEDTMTDMKWSKEDQVLDDQWIQKSRKKDSKAHAATSHLEGISWEVLVVNEPIVNAFCLPAGKIVVFTGLLNHFKSDAEVATVIGHEVGHAVARHVAEGITKNLWFAILQLVLYQFVMPDLVNTMSALFLRLPFSRKMEIEADYIGLLLLASAGYDPRVAPTVYEKLGKLGGDALGDYLSTHPSGKKRSKLLAQANVMEEALMIYREVQAGRTGVEGFL
InterPro domains: - IPR051156: Mitochondrial and Outer Membrane Metalloprotease (family) [131-483]
- IPR001915: Peptidase M48 (domain) [289-458]
Interaction partners: - Mitochondrial inner membrane protease ATP23
- Mitochondrial inner membrane protease subunit 2
- Peptidase S24/S26A/S26B/S26C family protein
- Mitochondrial ATP-independent inner membrane protease subunit 2
- Mitochondrial ATP-independent inner membrane protease subunit 1a
- Mitochondrial ATP-independent inner membrane protease subunit 1b
- ATP-dependent zinc metalloprotease FTSH 4, mitochondrial
- Intermediate cleaving peptidase 55, mitochondrial
- Protein LPA2
- Mitochondrial intermediate peptidase, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009628 (response to abiotic stimulus), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0001101 (response to acid chemical), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0048580 (regulation of post-embryonic development), GO:2000026 (regulation of multicellular organismal development), GO:0009415 (response to water), GO:1901564 (organonitrogen compound metabolic process), GO:2000280 (regulation of root development), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0019538 (protein metabolic process), GO:0006970 (response to osmotic stress), GO:0071495 (cellular response to endogenous stimulus), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0010029 (regulation of seed germination), GO:0036211 (protein modification process), GO:0097305 (response to alcohol), GO:0032870 (cellular response to hormone stimulus), GO:1900140 (regulation of seedling development), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid), GO:0006996 (organelle organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0061024 (membrane organization), GO:0007005 (mitochondrion organization), GO:0007006 (mitochondrial membrane organization), GO:0071215 (cellular response to abscisic acid stimulus), GO:0097306 (cellular response to alcohol), GO:0006468 (protein phosphorylation), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)