Protein: FUS RNA-binding protein (RNA-binding protein FUS) (F1R0M4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MASNDYGQTSSHGYGGYGGQSGQSYSQPSAQNYSQQSYGGYNQSSESSSAPYNQGGYSSNYGQSQSGGYGSQAPSQGYSQSSQSYSSGGYSNTSQPPPAQSGGYSQQSSYSGYNQSSPASAPGGYSSSSQSSGYGQQQQQSGGGYGGSGGQSGGYGSSGGQSSGFGGSGGQHQSSQSGGGSYSPSPNYSSPPPQSYGQQSQYGQGGYNQDSPPMSGGGGGGGYGGQDGGYSQDGRGGRGRGGGFGGRGAGGFDRGGRGGPRGRGGMGMGDRGGFNKFGGPRDHGAGGPNMQEQDNSDNNTIFVQGLGDDYTVDSVADYFKQIGIIKVNKKTGLPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKDFNGNPIKVSFATRRAEFGRGGSSGGMRGGRGRGGPMGRGGFGGGRGGGGGGGGFQGNNGGGSGNGGGQQRAGDWKCSNPSCGNLNFSWRNECNQCKEPKPEGSGGGMSPMGGGFGGERGRSGFDRGGFRGRGGDRGGFRGGRGGDRGGFGPGKMDSRGDHRHDRRDRPY
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [289-415]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [280-425]
- IPR036443: Zinc finger, RanBP2-type superfamily (homologous_superfamily) [433-474]
- IPR000504: RNA recognition motif domain (domain) [299-385]
- IPR034870: TAF15/EWS/TLS family (family) [273-541]
- IPR001876: Zinc finger, RanBP2-type (domain) [442-473]
Interaction partners: - TAR DNA-binding protein 43
- Guanine nucleotide exchange C9orf72 homolog
- Superoxide dismutase
- TAF15 RNA polymerase II, TATA box-binding protein
- Ataxin-2
- Transitional endoplasmic reticulum ATPase
- Drosha ribonuclease III.
- VAMP-associated protein B and C
- Senataxin.
- Cytotoxic granule associated RNA binding protein TIA1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0007017 (microtubule-based process), GO:0040008 (regulation of growth), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:2000026 (regulation of multicellular organismal development), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007051 (spindle organization), GO:0048731 (system development), GO:0001558 (regulation of cell growth), GO:0051231 (spindle elongation), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0051255 (spindle midzone assembly), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0048638 (regulation of developmental growth), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0022008 (neurogenesis), GO:0051225 (spindle assembly), GO:0098813 (nuclear chromosome segregation), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0061035 (regulation of cartilage development), GO:0007399 (nervous system development), GO:0060284 (regulation of cell development), GO:0140014 (mitotic nuclear division), GO:0032330 (regulation of chondrocyte differentiation), GO:0007417 (central nervous system development), GO:0051256 (mitotic spindle midzone assembly), GO:0000022 (mitotic spindle elongation), GO:0033043 (regulation of organelle organization), GO:0007052 (mitotic spindle organization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0051783 (regulation of nuclear division), GO:0000819 (sister chromatid segregation), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation), GO:0048285 (organelle fission), GO:0021954 (central nervous system neuron development), GO:0090307 (mitotic spindle assembly), GO:0051276 (chromosome organization), GO:0000280 (nuclear division), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)