Protein: Dynein heavy chain at 62B (Q7KVA7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MYTKKLERMHRPASDITKYDNEPYMKNPLLKFRISEVHERRHYQFLKQKAADVKVRVARQQWQPEPDMRLLPQSHYEDNLRREVRKIVVPPMLRRTEAKILSFASERLKNKYPELVQAYMHDVHEEFNRLMKVYSMKNILRHPEFSDEDPAQFELPRPDIGFRRPGRTQNYSNFLENRRRIAQKLLILQLPLRAILNISVGELPKLACIFNYVLATGAMQQQLGLGGREALSYKFYHKYIQNQLDKVNTFLRWTWYPKIVQVLRKLMRKRVMPMSTWKRSWNAMEALMNREMTNMKIRTFEEMYRMCSHPRTMPMMRMSLEWSEFSSDLDTRPNAWSILRTFAEIATEISMVGYRMEPLQPQVQTLTSMAAYAKVNDYLKIEMNDNFLKDVIDKVQNIILRTYQEVIQYVEGFRDKYYALYSWQERDALNQFLSEPHEFEEYFARIDMYYGFIQMLRSEPATEYFVMAVIHNEPAIFGLRTLAENLIHEITTIIIREHIKAEVDICDEFEKIKYRALEIPKSTEELLESAEYMIHVKKDKIAELTDRIQYCLQVGTNIVELTEMSKYHFDLTIKTINWIKDINDICDYNASQQEQFKFTFEEHLQEVIKKLNSDIDELLPKLTVIDDMSRPDKFRDSYIILQNFIDQLKTFDDYVAWINKEEKLFKVALTEYPKLDIIKTFVYPFAELMKCCIEWQRYLSVWNDGPFEYLEPQFVERTTDDYLKEFQKNQKYYRVKIKQDLIDNPVCKFKGQTEDPDPAKHPVPLRLCTSMIQSIKDFTTGVFIVNTMCNPALRKRHWKEMSEIAGFDVTPDAGTTLRKILNSGLDPILDQFEIISIGANKELQLWNALQAMIKEWETRVFPYGPYKETGVQILSSLDDIQALLDDHILKTLVMRGSAFMKPCEEEVRAWYEKIMRVNETLDQWGKVQANYLYLLPIFSSKDIVAQMPEEGRLFVIVEQTYTRNMGLVLRQPLVMETAPVSGLLESLQKANELLEDIATGVSNYLEKKRLYFPRFFFLANDEMLEILSETKDPLRVLPHLSKCFEGINSLEFDAAKNVLAMISSDKETIEFIEQVSTAAAGGSVEKWLIGVEDEMLKAVRYQNELSFAHYPKVKRHEWVLEWPQMTVLAISQVYWASRVHGCLRRTFGGNMTIMMNFFQELSKELNDIVTLVRSPKISNLNRITIKSLIVIDVHAKDVSEDLIKNKVSSEFDFQWLAQMRYYWEDDKTWVRIINATVPFANEYLGNSDRLVITPLTDRCYRTLVGAYQLHLNGAPEGPAGTGKTETTKDLAKALAVQCKVFNCSDGLDYKAMGKFFKGLASCGAWACFDEFNRIELEVLSVVAQQILLIIQAVRSNATKFMFEGTELTLNPACYVCITMNPGYAGRSELPDNLKVLFRSVAMMVPDYAMIGEISLYSYGFVDARKLAVKIVTTYRLCSEQLSSQNHYDYGMRAVKTVLSACGNIKKQYPDEVEDILLLRSLIDVNLPKFLSFDVPLFEGIISDIFPGIKLPHIDYSLVESEFKRVCLEEVLEPAPSFLLKVIQTYEMIIVRHGFMLVGEPLAGKSKTLQVLAKVLSALKIKAPQKSNYFQHVQMGIMNPKSITMNQLYGSFDPISYEWTDGLVAKIFRDFAMTPTPDRKWVIFDGPVDAVWIENMNTVLDDNKKLCLTSGEVITMSNEMSMVFEVMDLAQASPATVSRCGMIYMEPSTLGWRAFAKSWLKKADPRWADEEGVPYVMALMQWLLPPCQTFVRRFCSQFIKPGEFNCMLTTFDLFDMQIAEAIEENPEDYQKYLQTYFQAAILFALIWGVGGVLDTASREKFDVFLKKLWDTDPPPPEPLGKMEITPPTEGLLVDYVFLYKQRGAWRYWPDLAKRMDVEETKTGVIVPTVDTARYIHLLKMHVEHKKRMLLVGPTGTGKTVYVQNYLMNKLDKEVFETGFITFTVMISANQCQDLLISKLQKWKRGIYGPPKGMQSVLFVDDMNMPVKEVYGAQPPLELLRQFFDYGHVYDLKDSSKVYIHNVLIMAACGLPGGSRQDVYARFLNHFNVYSINTFSDDSMFRIFLNVALNGFRRAGHGQDVFVVTNQIVSATQSIYKSVQSEIRATPSKSHYIFNLRDISRVVTGCTLVRKESVSDKKIFVRVWYHEAMRVFYDRLVDDVDRKWMFDKLNECLKANFKDKVETVFERYCVQGPDEAVFTMEAASNILFGVYFDEDSVPDERRYEEVPSVEVFLNLALTSLDDYNSTRRNKMDITLFTFALQHLNRICRIISIQGASALIIGLGGSGRQSLTKLATNMVQTSFFQPEITKNYGANDWHDDIKAILKEAGGMNKHTTFLITENQIKMELFLQDIDCLLNQGEVPNIFPIDEKQEVLEMVRLAAQGGNRNIDVSALQVFSFFVDRCKQKLHMILSFSPIGDALRTRVRLYPSLVNCCTIDWYDSWPEEALQMIAKMSLVDVNVPSEDIKLAIMDTCQYFHTTAARSTRAFCQMTGRHIYQTNASFIELIRSFQTLIERKQSETMLAKMRYIGGLDTLAQAAAAISIMQRDLNALQPKLVALAESSRKMMLEINKETLAASAAAEQVKRDEEVASVQAEAAQVLKQDCERDLAKAIPVLEDALAALNTLKPADITLVKSMKNPPPVIKLVMAAVCVIKGIPPERIPDPASGKMVQDYWGPSKRLLGEMNFLPGLKEFDKDNIPTEIVKRIHKEFIPNKDFDPKVVAKASSAAKGLCQWIIAMMMYDEVAKVVAPKKAKLAGAEKEYADTMEFLAQKRALALALEEKVALLNIELDKANAEMQKTEEHAESCRNKLLRAEALIGGLGGEKSRWNKAAEDLQELYDHLPGDVLISCGIIAYLSAVNLQYRSECVKDWFKKVTDLKIPCSSHYSITDVLGLEVTIQNWQLDGLPNDEFSSENAIISANSSRYSLFIDPQAQANNWLKNMERKNRLNCVKFNQSNYMKVIAEALEYGTPVIIENVQEELEVPLDPILMRQTFVQGGIKHISLGESVVPVNPNFRLYMTCNLRNPHFLPETFNKVTVINFALTQNALMDQLLSIVVAKERPDLQELRITLTTEAAANKGALRDAENMILKTLSAGGDILENEAAIQILADSKGLSKDIVEKQEAAKETVAKIEAFRLNYKPVAVHSSILYYSITDLPNIDPMYQFSLNWYINLYMYSIETANKSKDLPRRIKFLVDGFTRNLYNNVCRSIFEKDKLLYSFILTARILLGTGQVEMRHFAHLVTNAKESTNIPPNPDPTWITETVWLNVLRLEELKELRGIVDHFKSHLHAWQAIYDHSSPEKQPLPPPWQDKTTAFEKIIVLKALRPDSVFLAVRLFIAESIGDQYVTPPEFDISKSYADSTALTPLVFILSPGADPLGSLLAFAEKMGQEETFQSISLGQGQGPIATALIKNAQEMGYWVCLQNCHLAASWMPYLEYLWENMDTFNTTPNFRIWLTAYPTPQFPVTILQNGVKMTNEPPTGLKENLMRSYNSEPINDYEFYTGCAKQDRAFTRLLYGICFFHAVVQERRKYGPLGWNIAYGFNESDLQISVLQLSMLLNQYDHVPYDAISYLTSECNYGGRVTDNWDRRLIVTILADFCNAQAVTDNRYRFASDDRYILPRKTEHREILRYLDENLPSLAPPEVYGLHANSGITRDLQTTKTLLDSMILLLGSEAAGSAGAGVSVEQVILDTIKQIEREMPADMDIEAAAEKYPVDYNESMNTVVVQEMERFLKLQKEIRTTCRDLAMGIKGIIVMTPDLENVMTAMKFNRIPTKWMSKSYPCLKPLGSYVQDLYKRLNWLHDWHHHGKPPTFWLSGFFFTQAFLTGAMQNFARKYKIPIDTLTFDYDVLKVETKTSPPDDGVYCNGLYLEGARWEWRENTLVEQFPKVLIYAMPVIFFRPVGLVDVVEGSRYRCPLYKTAERKGTLSTTGHSTNYVVPLLLNTHVKASHWVKRSVALICQTSD
InterPro domains: - IPR042219: Dynein heavy chain AAA lid domain superfamily (homologous_superfamily) [3478-3648]
- IPR024317: Dynein heavy chain, AAA module D4 (domain) [2249-2510]
- IPR041228: Dynein heavy chain, C-terminal domain (domain) [3658-3960]
- IPR041466: Dynein heavy chain, AAA 5 extension domain (domain) [1737-1868]
- IPR024743: Dynein heavy chain, coiled coil stalk (domain) [2529-2868]
- IPR003593: AAA+ ATPase domain (domain) [1269-2051]
- IPR042228: Dynein heavy chain, linker, subdomain 3 (homologous_superfamily) [1011-1108]
- IPR013602: Dynein heavy chain, linker (domain) [678-1102]
- IPR054354: Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain (domain) [2084-2159]
- IPR035699: Dynein heavy chain, hydrolytic ATP-binding dynein motor region (domain) [1240-1565]
- IPR043160: Dynein heavy chain, C-terminal domain, barrel region (homologous_superfamily) [3822-3964]
- IPR035706: Dynein heavy chain, ATP-binding dynein motor region (domain) [2897-3117]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1254-3477]
- IPR004273: Dynein heavy chain region D6 P-loop domain (domain) [3362-3475]
- IPR043157: Dynein heavy chain, AAA1 domain, small subdomain (homologous_superfamily) [1404-1513]
- IPR041658: Dynein heavy chain AAA lid domain (domain) [3511-3650]
- IPR026983: Dynein heavy chain (family) [230-3963]
- IPR042222: Dynein heavy chain, domain 2, N-terminal (homologous_superfamily) [861-1009]
Interaction partners: - Dynein light chain Tctex-type
- Dynein light intermediate chain
- Dynein light chain roadblock
- Uncharacterized protein, isoform B
- Dynein axonemal intermediate chain 4
- Dynein heavy chain at 93AB, isoform C
- Dynein axonemal heavy chain 7
- Putative inner dynein arm light chain, axonemal
- Male fertility factor kl5
- Dynein axonemal light chain 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140657 (ATP-dependent activity), GO:0003774 (cytoskeletal motor activity), GO:0003777 (microtubule motor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0007017 (microtubule-based process), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0007018 (microtubule-based movement), GO:0030317 (flagellated sperm motility), GO:0003341 (cilium movement), GO:0060285 (cilium-dependent cell motility), GO:0060294 (cilium movement involved in cell motility)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium), GO:0036126 (sperm flagellum)