Protein: Stimulated by retinoic acid gene 8 protein (P70278)
Organism: Mus musculus (Mouse)
Function: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:19805549, ECO:0000269|PubMed:32032549, ECO:0000269|PubMed:8896602}. Nucleus {ECO:0000269|PubMed:19805549, ECO:0000269|PubMed:32032549}. Note=Shuttles between nucleus and cytoplasm (PubMed:19805549). Nuclear export is XPO1-dependent (PubMed:19805549). {ECO:0000269|PubMed:19805549}.
Sequence: MATPGEGNQPSDDGAPQPLAQLQKLEPRVVRRRLSQARHRATLVGLFNNLRKAVYSQSDITASKWQVLNRTKIHIQEQEESLDKLLKLKASFNLQDGNPNSLEEVKEEYARMYSENDSVFLNSFLQDSPPEWFPSEAVGPDAEEEGEEEGEEEGEEGEEEEEGDEEGEEEEENGEEREVEEYQEEEEEEEEEEKKVDLSHSSSTLLPDLMEFERYLNFYKQTMDLLTMNSIISAHEVTLPIVSAAISHLWQTLSEEKKARLLQVWEQQHSAFADLTEACLELAGVEGSMKDSGVDSQGASCSLESTPEEILFEDAFDVASFLDKSEAQHMSNISAMFATCNSENPEEKFQLYIQIIEFFKSLGCVNTPLNQEPEPPDDDDAMLLKCLETFDDL
InterPro domains: - IPR033537: Stimulated by retinoic acid gene 8 protein (family) [1-392]
- IPR057021: STRA8, bHLH domain (domain) [14-93]
Interaction partners: - Deleted in azoospermia-like
- Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1
- Nanos homolog 2
- Synaptonemal complex protein 3
- Meiotic recombination protein REC8 homolog
- ATP-dependent RNA helicase DDX4
- Cytochrome P450 26B1
- Meiotic recombination protein SPO11
- Predicted gene 4969.
- Meiotic recombination protein DMC1/LIM15 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:2000241 (regulation of reproductive process), GO:0051321 (meiotic cell cycle), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009892 (negative regulation of metabolic process), GO:2000243 (positive regulation of reproductive process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:1903046 (meiotic cell cycle process), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0048522 (positive regulation of cellular process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044092 (negative regulation of molecular function), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0007283 (spermatogenesis), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0051445 (regulation of meiotic cell cycle), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0051446 (positive regulation of meiotic cell cycle), GO:0010564 (regulation of cell cycle process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048477 (oogenesis), GO:0010468 (regulation of gene expression), GO:0043433 (negative regulation of DNA-binding transcription factor activity), GO:0007292 (female gamete generation), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0048232 (male gamete generation), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0007096 (regulation of exit from mitosis), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)