Protein: Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2) (Q9VRJ2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity). May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for correct morphology of nociceptive multi-dendritic sensory neurons. Required for normal mechanical amplification in hearing.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03230}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03230}.
Sequence: MATKRRPLRPNLGGTAGSPSSSGSNMNFRPGGPDITRSEARGTRPTAAPTSIREILVMGVIHLCKKTIFFNTDLKVALYLGSLFVISVIGDFVPFPKTYFARSDNLFNQYFVKIGWGWTLLFVVPFLVLSAYTITCGDHKRMLRHHFPRIVIATFFWFFWTKLFNVVENSYGRCTTKGYATKSSCLKAGHLWKGFDISGHAFILIHSSLVLIEEARPIIRWETIKEHIRNERHNRSTAENSGTNPLRTLNEEQMRSLQFLYKRLTPIIRTLFIGMAALQLLWDIMLVGTMLYYHRMIEKVISGIIAILTWYFTYRFWYPTPGLLPEAPGNGSFSYQREIPTFPFKRPSHLSTGAATTSSGSNSSRTNLNGKAATTGVPRDQQIPTFMGMPLFTSPKAASAAANLLMSDQQKRERDREQQTLES
InterPro domains: - IPR019388: Fat storage-inducing transmembrane protein (family) [24-338]
- IPR046401: Fat storage-inducing transmembrane protein 1/2 (family) [51-337]
Interaction partners: - Atlastin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0043474 (pigment metabolic process involved in pigmentation), GO:0048066 (developmental pigmentation), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043324 (pigment metabolic process involved in developmental pigmentation), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0046148 (pigment biosynthetic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0048069 (eye pigmentation), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0016063 (rhodopsin biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0046154 (rhodopsin metabolic process), GO:0042441 (eye pigment metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0008055 (ocellus pigment biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006996 (organelle organization), GO:0006726 (eye pigment biosynthetic process), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0031047 (RNA-mediated gene silencing), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)