Protein: Dolichyl-phosphate-mannose--protein mannosyltransferase 1 (Protein mannosyltransferase 1) (EC 2.4.1.109) (O74189)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentation and early phases of biofilm formation.
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33775}.
Sequence: MAKKPVTPASKVAAKQAAVRSRHQEDVFTLDPLIDPIFQKGELRSYLVTEPSPSVLKKRSIHTKEYWMLSSLLLIAFYVRMYNLSNPNSVVFDEVHFGGFARKYILGTFFMDVHPPLAKMLFGAVGAIGGFKGDFEFKSIGDKFPDSTPYIFMRQFPALLGVGTVILCYLTLRQSGVRPIIAYITTFLLIIENSNVTISRYILLDSPLIFFIAAAIYAWKKFEIQIPFTFGWYRSLLATGIALGLALSSKWVGLFTVAWVGFLCIYQLWFLIGDLSVSTKKIWGHFFARGIILLGVPIALYLGFFAIHFQLLNKEGDGGAFMSSAFRAGLQGNKIPRDITEQVGLGSVVTIRHVDTQGGYLHSHEHFYQTGSKQQQITLYPHLDSNNKWLIEPYNGTIHNETFVPLINGMKIRLKHINTGRRLHSHDEKPPVSERDWQKECSCYGYDGFAGDANDDWVVEIVNYRSQKGEAQTFVKAINTIFRLRHAMTGHYLFSSEVKLPEWGFGQQEVTSASQGKRALTHWYIETNENSILPPSEAKIINYPKLSLWQKVVESHKRMWKINQGLTSHHHWQSSPSEWPLLLRGINYWNKEHKQVYLLGNAVTWWAATLSIITFGTYVLVTVFRWHLGTPLSTNKHVFNFNVQTFSYVLGWALHYLPFFIMGRQLFLHHYLPALYFGILALGHFFEIFTGYLTSRSKYFQQVAFVLVGLFSILSLVFYVNYSSLIYGTPWTKASCELTKPFSGWDYNCGTFFDTLGEYDIQEKSLASESEIPTETVVVEAKQTPKAEPKLAKQDDHIESPAAAEPVEEKEVKEEVEQLAPPLAVDFEEETPKVEDPQVADVDASSNDEKSVEEKQQQEQQQEQEQVEDESVHQVQQ
InterPro domains: - IPR016093: MIR motif (domain) [340-528]
- IPR003342: ArnT-like, N-terminal domain (domain) [71-313]
- IPR027005: O-mannosyl-transferase-like (family) [8-749]
- IPR036300: Mir domain superfamily (homologous_superfamily) [341-526]
- IPR032421: Protein O-mannosyl-transferase, C-terminal four TM domain (domain) [549-745]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0040007 (growth), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071554 (cell wall organization or biogenesis), GO:0006807 (nitrogen compound metabolic process), GO:0070085 (glycosylation), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0030448 (hyphal growth), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0104004 (cellular response to environmental stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0097502 (mannosylation), GO:0071214 (cellular response to abiotic stimulus), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0071555 (cell wall organization), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043413 (macromolecule glycosylation), GO:1901135 (carbohydrate derivative metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006486 (protein glycosylation), GO:0031505 (fungal-type cell wall organization), GO:0043412 (macromolecule modification), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0009100 (glycoprotein metabolic process), GO:0035268 (protein mannosylation), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0045229 (external encapsulating structure organization), GO:0071467 (cellular response to pH), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0036244 (cellular response to neutral pH), GO:0009101 (glycoprotein biosynthetic process), GO:0006493 (protein O-linked glycosylation), GO:0035269 (protein O-linked mannosylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)