Protein: Dedicator of cytokinesis 8 (A2A369)
Organism: Homo sapiens (Human)
Sequence: MTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIREWLIVNRKNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSEPAAQAGPRHLNVLCDVSGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFALYPSVDEEDAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLNSDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTVIKESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSVVGRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFLADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPENRTRPHKEILEFPTREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGPEFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGYSWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQAVSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPLVLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLLASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDLAGTHSAADEEVKNIMSSKHFHEELALQMVVSTGMVRETVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVTSEIAALLVKPQKENEQAEKMNISLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPTLISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQDQKIASMFDLTSEYRQQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVKVKIAALYLPLVGIILDALPQLCDFTVADTRRYRTSGSDEEQEGAGAINQNVALAIAGNNFNLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLPSTQLNRILDLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMRRRAPGNDRFPGLNENLRWKKEQTHWRQANEKLDKTKAELDQEALISGNLATEAHLIILDMQENIIQASSALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEEVEQCFDLCHQVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAPDFNEEHLRRSLRTILAYSEEDTAMQMTPFPTQVEELLCNLNSILYDTVKMREFQEDPEMLMDLMYRIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLEDHSYLPVGSVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETVNEVYKLVIPILEAHREFRKLTLTHSKLQRAFDSIVNKDHKRMFGTYFRVGFFGSKFGDLDEQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFVEPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLTTMHAFPYIKTRISVIQKEEFVLTPIEVAIEDMKKKTLQLAVAINQEPPDAKMLQMVLQGSVGATVNQGPLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRSTASSATTGQRPF
InterPro domains: - IPR021816: Dedicator of cytokinesis C/D, N-terminal (domain) [2-98]
- IPR027007: C2 DOCK-type domain (domain) [488-670]
- IPR043161: Dedicator of cytokinesis, C-terminal, lobe A (homologous_superfamily) [1532-1688]
- IPR016024: Armadillo-type fold (homologous_superfamily) [1352-1482]
- IPR027357: DOCKER domain (domain) [1532-1936]
- IPR046769: DOCKER, Lobe A (domain) [1525-1683]
- IPR046770: DOCKER, Lobe B (domain) [1748-1823]
- IPR046773: DOCKER, Lobe C (domain) [1859-1922]
- IPR026791: Dedicator of cytokinesis (family) [8-1923]
- IPR035892: C2 domain superfamily (homologous_superfamily) [492-671]
- IPR037808: Dedicator of cytokinesis C, C2 domain (domain) [491-671]
- IPR043162: Dedicator of cytokinesis, C-terminal, lobe C (homologous_superfamily) [1844-1930]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:2000145 (regulation of cell motility), GO:0002685 (regulation of leukocyte migration), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0010033 (response to organic substance), GO:2000147 (positive regulation of cell motility), GO:0046649 (lymphocyte activation), GO:0050867 (positive regulation of cell activation), GO:0002687 (positive regulation of leukocyte migration), GO:0002696 (positive regulation of leukocyte activation), GO:0070661 (leukocyte proliferation), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0032878 (regulation of establishment or maintenance of cell polarity), GO:0050865 (regulation of cell activation), GO:0034097 (response to cytokine), GO:0046651 (lymphocyte proliferation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0022407 (regulation of cell-cell adhesion), GO:0030334 (regulation of cell migration), GO:2000114 (regulation of establishment of cell polarity), GO:0032943 (mononuclear cell proliferation), GO:0051251 (positive regulation of lymphocyte activation), GO:0071677 (positive regulation of mononuclear cell migration), GO:0042110 (T cell activation), GO:0030335 (positive regulation of cell migration), GO:0071675 (regulation of mononuclear cell migration), GO:0043085 (positive regulation of catalytic activity), GO:1902531 (regulation of intracellular signal transduction), GO:0051249 (regulation of lymphocyte activation), GO:0050870 (positive regulation of T cell activation), GO:0050863 (regulation of T cell activation), GO:2000401 (regulation of lymphocyte migration), GO:0071345 (cellular response to cytokine stimulus), GO:2000403 (positive regulation of lymphocyte migration), GO:0042098 (T cell proliferation), GO:0043087 (regulation of GTPase activity), GO:1990868 (response to chemokine), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0051345 (positive regulation of hydrolase activity), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:1990869 (cellular response to chemokine), GO:2000406 (positive regulation of T cell migration), GO:0043547 (positive regulation of GTPase activity), GO:2000404 (regulation of T cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0031256 (leading edge membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)