Protein: Calpain-10 (EC 3.4.22.-) (Calcium-activated neutral proteinase 10) (CANP 10) (Q9ESK3)
Organism: Mus musculus (Mouse)
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake (By similarity).
Sequence: MRAVRAETPARELFRDAAFPASDSSLFYNLSTPLAQFREDITWRRPQEICATPQLFPDNPWEGQVKQGLLGDCWFLCACAALQKSQHLLDQVFPPGQPGWSDQKYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFSRCQREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKDVTKASGQQDRPSGGEHRTCRQLLHLKDRCLISCSVLSPRAGARELGEFHAFIISDLQELRSQTGQGILLLRIHNPWGRRCWQGLWREGGEGWNQVEPAKESELLAQLQEGEFWVEEEEFLREFDEVTIGYPVTEAGHLQSLHTERVLCHTRTLPGAWVTGQSAGGCRNNSCFPCNPKFWLRLLEPSEVCVAVLQRPRRRLVGQTRALAGASPAPVNLPGKDYQAVGLHIWKVEKRKISLPRVLSAPPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFSTGKISLSAVRLATKGASPGTALPAGEWETVQLQGCWRAGQTAGGSRNFASYPCNPCLPFSVPEGAGPRYIRITLQQHCRLSDSQLHPIGFHVFQVPADGENQDACSLLLQEPLLSCVPHRYAQEVSRLCLLSVGNYRIVPSTYLPDTEGTFTVTIATRIDRQSIHSQEMLGQLLQEVSFMAVMKA
InterPro domains: - IPR022683: Peptidase C2, calpain, domain III (domain) [338-645]
- IPR001300: Peptidase C2, calpain, catalytic domain (domain) [2-329]
- IPR036213: Calpain large subunit, domain III superfamily (homologous_superfamily) [338-647]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [67-78]
- IPR033883: Calpain subdomain III (domain) [337-647]
- IPR022684: Peptidase C2, calpain family (family) [11-488]
- IPR022682: Peptidase C2, calpain, large subunit, domain III (domain) [344-636]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [9-317]
Interaction partners: - Calpain small subunit 1
- Calpastatin
- Calpain small subunit 2
- Aminopeptidase RNPEPL1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0030029 (actin filament-based process), GO:0061919 (process utilizing autophagic mechanism), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0001101 (response to acid chemical), GO:0009991 (response to extracellular stimulus), GO:0061061 (muscle structure development), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0030036 (actin cytoskeleton organization), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0006914 (autophagy), GO:1902074 (response to salt), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0031667 (response to nutrient levels), GO:0000422 (autophagy of mitochondrion), GO:0006996 (organelle organization), GO:0022411 (cellular component disassembly), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0007005 (mitochondrion organization), GO:0051146 (striated muscle cell differentiation), GO:1905037 (autophagosome organization), GO:0055002 (striated muscle cell development), GO:1903008 (organelle disassembly), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0019867 (outer membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031970 (organelle envelope lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0019866 (organelle inner membrane), GO:0031968 (organelle outer membrane), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane), GO:0005758 (mitochondrial intermembrane space), GO:0005743 (mitochondrial inner membrane), GO:0005634 (nucleus), GO:0005856 (cytoskeleton)