Protein: Transmembrane anterior posterior transformation protein 1 homolog (Cytomegalovirus partial fusion receptor) (Q6NXT6)
Organism: Homo sapiens (Human)
Function: Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26365339}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:26365339}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MAGVGDAAAPGEGGGGGVDGPQRDGRGEAEQPGGSGGQGPPPAPQLTETLGFYESDRRRERRRGRTELSLLRFLSAELTRGYFLEHNEAKYTERRERVYTCLRIPRELEKLMVFGIFLCLDAFLYVFTLLPLRVFLALFRLLTLPCYGLRDRRLLQPAQVCDILKGVILVICYFMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERKRAHIGVIPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVIASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYSDSVARRMGFIPLPLAVLLIRVVTSSIKVQGILSYACVILFYFGLISLKVLNSIVLLGKSCQYVKEAKMEEKLSNPPATCTPGKPSSKSQNKCKPSQGLSTEENLSASITKQPIHQKENIIPLLVTSNSDQFLTTPDGDEKDITQDNSELKHRSSKKDLLEIDRFTICGNRID
InterPro domains: - IPR008010: Tapt1 family (family) [61-566]
Interaction partners: - Homeobox protein Hox-C8
- Cleavage stimulation factor subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051051 (negative regulation of transport), GO:0048523 (negative regulation of cellular process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0016043 (cellular component organization), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0006810 (transport), GO:0032387 (negative regulation of intracellular transport), GO:1905476 (negative regulation of protein localization to membrane), GO:0032880 (regulation of protein localization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:1904950 (negative regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0016050 (vesicle organization), GO:0048284 (organelle fusion), GO:0065005 (protein-lipid complex assembly), GO:0072528 (pyrimidine-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0035579 (specific granule membrane)