Protein: Rap guanine nucleotide exchange factor (GEF) 1 (Q3UHC1)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MSSGLGLRRSPEMSGKIEKADSQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKIPEKPVSKEARDRFLPEGYPIPLDLEQQAVEFMSTSAVASRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPLVQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTTVKGVIKAVLDGVKELVRLTIEKQGRPSPTSPVKPSSPASKPDGQPELPLTDREMEILNKTTSVSPSAELLPDSTSEEVAPPKPPLPGIRVVDNSPPALPPKKRQSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVECYTQRRLSGGSRSCGGESPRLSPCSSTGKLSRSDEQLSSLDRDSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPPQAACNLSPLPESLGESGPPFLGHPFQLPLGSCLQQEGQQTDTPPALPEKKRRSAVSQTTDSSGCRVSYERHPSQYDNISEGDLQNPVPVQPVPYPPFAAVLPFQQGASSASAEFVGDFSVPELAGDTEKPPPLPEKKNKHMLAYMQLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSESFCGSDSTQELAPPPALPPKQRQLQASYAASSFSVSYCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSYSQDFMPHHQASVQPFLPPTSSSSPHFPPVHTSQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHGNPVRLPSETSFTDSEPPSGKDGHPRDPSVSSASGKDSRENGERSPKSLDGLESAQSEEEVDELSLIDHNEIMARLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQFNILDSMRCFQQAHYEIRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEKT
InterPro domains: - IPR036964: Ras guanine-nucleotide exchange factor, catalytic domain superfamily (homologous_superfamily) [980-1224]
- IPR001895: Ras guanine-nucleotide exchange factors catalytic domain (domain) [983-1212]
- IPR019804: Ras guanine-nucleotide exchange factor, conserved site (conserved_site) [1129-1158]
- IPR000651: Ras-like guanine nucleotide exchange factor, N-terminal (domain) [834-976]
- IPR008937: Ras-like guanine nucleotide exchange factor (family) [723-1214]
- IPR023578: Ras guanine nucleotide exchange factor domain superfamily (homologous_superfamily) [815-1212]
Interaction partners: - Crk-like protein
- Adapter molecule crk
- E3 ubiquitin-protein ligase CBL
- Breast cancer anti-estrogen resistance protein 1
- Growth factor receptor-bound protein 2
- Ras-related protein Rap-1A
- Fibroblast growth factor receptor substrate 2
- GTPase HRas
- Rho-related GTP-binding protein RhoQ
- GTPase KRas
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0008283 (cell population proliferation), GO:0007155 (cell adhesion), GO:0007267 (cell-cell signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050790 (regulation of catalytic activity), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0061351 (neural precursor cell proliferation), GO:0044093 (positive regulation of molecular function), GO:0035556 (intracellular signal transduction), GO:0198738 (cell-cell signaling by wnt), GO:0098609 (cell-cell adhesion), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0008285 (negative regulation of cell population proliferation), GO:0009966 (regulation of signal transduction), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0007166 (cell surface receptor signaling pathway), GO:0043491 (protein kinase B signaling), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0016055 (Wnt signaling pathway), GO:2000178 (negative regulation of neural precursor cell proliferation), GO:0001944 (vasculature development), GO:0051336 (regulation of hydrolase activity), GO:0000165 (MAPK cascade), GO:0030111 (regulation of Wnt signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:2000177 (regulation of neural precursor cell proliferation), GO:0072359 (circulatory system development), GO:0030178 (negative regulation of Wnt signaling pathway), GO:0007264 (small GTPase mediated signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0051058 (negative regulation of small GTPase mediated signal transduction), GO:0060070 (canonical Wnt signaling pathway), GO:0051898 (negative regulation of protein kinase B signaling), GO:0043087 (regulation of GTPase activity), GO:0007265 (Ras protein signal transduction), GO:0070371 (ERK1 and ERK2 cascade), GO:0051896 (regulation of protein kinase B signaling), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0051345 (positive regulation of hydrolase activity), GO:0090090 (negative regulation of canonical Wnt signaling pathway), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0043409 (negative regulation of MAPK cascade), GO:0046578 (regulation of Ras protein signal transduction), GO:0043547 (positive regulation of GTPase activity), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0046580 (negative regulation of Ras protein signal transduction), GO:0048008 (platelet-derived growth factor receptor signaling pathway), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0090630 (activation of GTPase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)