Protein: NAD-dependent protein deacetylase HST1 (Q5AQ47)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability
Subcellular location: Nucleus
Sequence: MPGDNDIVLVDSSSDNEEEREEDDDDESQHREIKKFKPNPNPSQTRDMNESHVINKSNFSTVPFNAVSSSSSSDNDQDNDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEESEINGNQISLSIDDEYDSEGLTKESSRTPIGSNTSDIIINGVTIITNNNDSSLVASSSDDDDDDDDDDDKDDDNDDDASDLESDFAFEEIPPSLIMETRKYLKQNGTMKFLEKYLPTAASIENIIKLILQLGFVPKRKLNNGLDENDIMEYIKILNHAIIKVKSIRERREDITTINDALKLIENSKNIMVITGAGISTSLGIPDFRSSQGFYSMIQHLGLSDPQEVFDLDLFLNDPNIFYSIAHMILPPNHIYSPLHSFIKLLQDKNKLLRNYTQNIDNLESYAGIHKENLIQCHGSFATASCITCGYKVDGEIIFPEIKNKEIPYCPKCNEVKQSILKKGKKTKSKSKKKKKKKNKPYDDDDEEEEEGETYFHESFGVMKPDITFFGEQLPENFKIAINQDINKVDLVLVIGTSLKVAPVADIVGKIPEHIPQILLNKDPINHCQFDVSLLGYCDDVASYIANELGESWDLPHPDYNKIRGEKNGENLSVQLLDSTLREYLISNKKNDLSSEQEQNKMGEENRKVEESGRRPNESGGKSG
InterPro domains: - IPR026591: Sirtuin, catalytic core small domain superfamily (homologous_superfamily) [313-506]
- IPR029035: DHS-like NAD/FAD-binding domain superfamily (homologous_superfamily) [270-586]
- IPR007654: NAD-dependent histone deacetylase Sir2, N-terminal (domain) [197-251]
- IPR003000: Sirtuin family (family) [307-534]
- IPR026590: Sirtuin family, catalytic core domain (domain) [282-583]
- IPR050134: NAD-dependent sirtuin protein deacylases (family) [283-587]
Interaction partners: - nicotinamidase
- Nicotinamide-nucleotide adenylyltransferase
- Glutamine-dependent NAD(+) synthetase
- Trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase
- NADH/NAD(+) kinase
- Purine nucleoside phosphorylase
- NAD(+) diphosphatase
- Nicotinamide-nucleotide adenylyltransferase
- Histone deacetylase
- tRNA (guanine(10)-N(2))-methyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0004407 (histone deacetylase activity), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides), GO:0034979 (NAD-dependent protein deacetylase activity), GO:0017136 (NAD-dependent histone deacetylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0006259 (DNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051276 (chromosome organization), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)