Protein: Para-hydroxybenzoate-polyprenyltransferaseCoq2 (T0S324)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate
Subcellular location: Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side
Sequence: YSSSETSDQRCNGVRSKTKEKRTALFEKIKTYGSLSRVHAPVGTILLYCPCTWSILMAAYSIKVPIFSTVKVLTIFALGSFVMRSAGCVINDLWDRKLDAKVRRSSNRPLANGKVGVPEALGLLGVQLSTALIILCSLNSYTVKLGVLSLLPVSLYPSFKRFTYYPQAFLGLTFSYGALMGWPALVGADAMFWPVVAPLYLSSVFWVIMYDTIYAHQDKLDDVHAGIYSTALKFGKRTKPVLFLLASIQYVFLSFAGMANHQGPIFYLLGVCGSYISTLLMIFNVNLNSPKNCMHWFKQNSKMGYAITLAITLDWIISFLK
InterPro domains: - IPR000537: UbiA prenyltransferase (family) [50-297]
- IPR006370: 4-hydroxybenzoate polyprenyltransferase-like (family) [25-316]
- IPR039653: Prenyltransferase (family) [17-317]
- IPR044878: UbiA prenyltransferase superfamily (homologous_superfamily) [42-193]
- IPR030470: UbiA prenyltransferase conserved site (conserved_site) [91-113]
Interaction partners: - 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
- Ubiquinone biosynthesis O-methyltransferase, mitochondrial
- Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
- Phosphatidate cytidylyltransferase
- isopentenyl-diphosphate Delta-isomerase
- Ferrochelatase
- Atypical/ABC1/ABC1-A protein kinase Abc1
- 5-demethoxyubiquinone hydroxylase, mitochondrial
- Type I ferredoxin Etp1/cytochrome oxidase cofactor Cox15
- Decaprenyl diphosphate synthase subunit Dps1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004659 (prenyltransferase activity), GO:0004337 (geranyltranstransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0042180 (cellular ketone metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:1901661 (quinone metabolic process), GO:0042181 (ketone biosynthetic process), GO:0006743 (ubiquinone metabolic process), GO:1901663 (quinone biosynthetic process), GO:0006744 (ubiquinone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)