Protein: Nicastrin (F4J819)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MAMGLIRLLSIAFTLVLLSILPLHLSLADEITSIESVPDLQKLMYVAVDGFPCVRLLNLSGEIGCSNPGINKVVAPIIKLKDVKDLVQPHTILVTADEMEDFFTRVSTDLSFASKIGGVLVESGSNFQQKLKGFSPDKRFPQAQFSPYENVEYKWNSAASSIMWRNYNFPVYLLSESGISAVHEILSKKKMKHGTYTSDVAEFNMVMETTKAGTHNSEACLQEGTCLPLGGYSVWSSLPPISVSSSNNRKPVVLTVASMDTASFFRDKSFGADSPISGLVALLGAVDALSRVDGISNLKKQLVFLVLTGETWGYLGSRRFLHELDLHSDAVAGLSNTSIETVLEIGSVGKGLSGGINTFFAHKTRVSSVTNMTLDALKIAQDSLASKNIKILSADTANPGIPPSSLMAFMRKNPQTSAVVLEDFDTNFVNKFYHSHLDDLCKKSHSLSFSSFRSKPHFALLIPFWCCIAANINSSSVVAAASVVARTLYILASDNKDTSNSALGSIHVNASFVEELLTCLLACEPGLSCNLVKDYISPTNTCPGNYAGVILGEPSSKPYLGYVGDVSRFLWNFLADKTSVQKGNTTSVCSKGVCSKTDEVCIKAESNKEGTCVVSTTRYVPAYSTRLKYNDGAWTILPQNSSDSMGMVDPVWTESNWDTLRVHVYTVQHSAYDNAVLVAGITVTTLAYIGILAAKSIITKALKQD
InterPro domains: - IPR041084: Nicastrin, small lobe (domain) [52-209]
- IPR008710: Nicastrin (family) [17-704]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0070001 (aspartic-type peptidase activity), GO:0004190 (aspartic-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0051716 (cellular response to stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009791 (post-embryonic development), GO:0048316 (seed development), GO:0007166 (cell surface receptor signaling pathway), GO:0048608 (reproductive structure development), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0009793 (embryo development ending in seed dormancy), GO:0043170 (macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0043170 (macromolecule metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0010228 (vegetative to reproductive phase transition of meristem), GO:0036211 (protein modification process), GO:0061458 (reproductive system development), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle)