Protein: Calmodulin-lysine N-methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60) (Q3U2J5)
Organism: Mus musculus (Mouse)
Function: Catalyzes the trimethylation of 'Lys-116' in calmodulin.
Subcellular location: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q7Z624}. Nucleus {ECO:0000250|UniProtKB:Q7Z624}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus {ECO:0000250|UniProtKB:Q7Z624}.
Sequence: MESQVAAAGAAETEAEAGKRPAMGSASQGSLVSAPKGAVRWQLLRQVLKQKQLDDHLRHVSVRRFESFNLFSVTEATKKGTEKEAGVWVQYTSIFYPKYSISVRHNSGSLNVEDVLTSFDNTGNVCIWPSEEVLAHYCLKHSHIFRDLAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIRNVDSIIACNKKTGVFKTPKISSRVLRWDNETDVSQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAPRRGNTFNQFCNLAEKAGFSLQRHENYDEPISNFHSKLKKEGSDIYEENLHYPLLLILTKTG
InterPro domains: - IPR025800: Calmodulin-lysine N-methyltransferase (family) [1-323]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [60-323]
- IPR019410: Lysine methyltransferase (family) [125-276]
Interaction partners: - Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
- Calmodulin-1
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Prolyl endopeptidase-like
- Histidine protein methyltransferase 1 homolog
- Methyltransferase-like protein 22
- N-lysine methyltransferase KMT5A
- Histone-lysine N-methyltransferase EHMT2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0032101 (regulation of response to external stimulus), GO:0043414 (macromolecule methylation), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0022400 (regulation of rhodopsin mediated signaling pathway), GO:0008213 (protein alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)