Protein: Synaptic vesicle glycoprotein 2A (E7F6Z2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Presynapse
Sequence: MDEGYRDRSAFIKGAKDIAKEVKRHAGKKVGRHVDKMTDEYTKRSYTRFEEDDDDDDYPVQAQDGSYYRSNSRANDDEGAHSDSTEGHDEDDEIYEGEYQGIPRNDSVEKADRQVGAVGQSQFRDMTQYEGERRKDQEELAQQYETILQECGHGRFQWTLYFVLGLALMADGVEIFVVGFVLPSAEKDMCLSEPNKGMLGLIVYLGMMVGAFVWGGLADRIGRRQTLLISLSINSVFAFFSSFVQGYSSFLFCRLLSGVGIGGSIPIVFSYYSEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVAAIAALTTMPESPRFYLENGKHDEAWMILKQVHDTNMRAKGYPERVFSVTTIKTVKQMDELVDMGGEATAWHQRWRIKLTNLFHQVWGNFLTVFNPEYRRITYMMMAVWFSMSFSYYGLTVWFPDMIKYLQKQEYSSRTKVFIKEKVEHVTFNFTLENQIHRNGEYFNNKFLNLKMKSMVFEDSLFEECYFEDITSSNTFFRNCTFISTLFYNTDLFKYRLINSKLINSTFLHNKEGCMLDFSDENNAYMIYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVISCVSCFFLSFGNSESAMIALLCLFGGISIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFQSFVGITKAVPILFASGALAAGSFLALKLPETRGQVLQ
InterPro domains: - IPR022308: Synaptic vesicle protein SV2 (family) [1-733]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [146-733]
- IPR005828: Major facilitator, sugar transporter-like (family) [192-446]
- IPR020846: Major facilitator superfamily domain (domain) [160-728]
- IPR011701: Major facilitator superfamily (family) [588-727]
- IPR005829: Sugar transporter, conserved site (conserved_site) [256-281]
- IPR055415: SV2A/B/C, luminal domain (domain) [477-568]
Interaction partners: - Protein unc-93 homolog A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048066 (developmental pigmentation), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0009894 (regulation of catabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0009895 (negative regulation of catabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0060041 (retina development in camera-type eye), GO:0022008 (neurogenesis), GO:0048882 (lateral line development), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0048880 (sensory system development), GO:0031330 (negative regulation of cellular catabolic process), GO:0007423 (sensory organ development), GO:0051248 (negative regulation of protein metabolic process), GO:0030318 (melanocyte differentiation), GO:0060429 (epithelium development), GO:0031329 (regulation of cellular catabolic process), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0030855 (epithelial cell differentiation), GO:0042471 (ear morphogenesis), GO:0001654 (eye development), GO:0030162 (regulation of proteolysis), GO:0048699 (generation of neurons), GO:1901799 (negative regulation of proteasomal protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0045861 (negative regulation of proteolysis), GO:0150063 (visual system development), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:1903051 (negative regulation of proteolysis involved in protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030054 (cell junction), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0030133 (transport vesicle), GO:0070382 (exocytic vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)