Protein: Choline-phosphate cytidylyltransferase 1 (AtCCT1) (EC 2.7.7.15) (CTP:phosphocholine cytidylyltransferase 1) (Phosphorylcholine transferase 1) (Q9ZV56)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plays an important role in the biosynthesis of the phospholipid phosphatidylcholine. Catalyzes the formation of CDP-choline.
Sequence: MSNVIGDRTEDGLSTAAAASGSTAVQSSPPTDRPVRVYADGIYDLFHFGHARSLEQAKLAFPNNTYLLVGCCNDETTHKYKGRTVMTAEERYESLRHCKWVDEVIPDAPWVVNQEFLDKHQIDYVAHDSLPYADSSGAGKDVYEFVKKVGRFKETQRTEGISTSDIIMRIVKDYNQYVMRNLDRGYSREDLGVSFVKEKRLRVNMRLKKLQERVKEQQERVGEKIQTVKMLRNEWVENADRWVAGFLEIFEEGCHKMGTAIVDSIQERLMRQKSAERLENGQDDDTDDQFYEEYFDHDMGSDDDEDEKFYDEEEVKEEETEKTVMTDAKDNK
InterPro domains: - IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [13-252]
- IPR004821: Cytidyltransferase-like domain (domain) [36-168]
- IPR041723: CTP:phosphocholine cytidylyltransferase domain (domain) [33-185]
- IPR045049: Choline-phosphate cytidylyltransferase Pcy1-like (family) [24-315]
Interaction partners: - Probable choline kinase 1
- Phosphoethanolamine N-methyltransferase 1
- Probable choline kinase 2
- Probable choline kinase 3
- Phosphoethanolamine N-methyltransferase 2
- Phosphoethanolamine N-methyltransferase 3
- Choline/ethanolaminephosphotransferase 2
- Choline/ethanolaminephosphotransferase 1
- Choline-phosphate cytidylyltransferase 2
- Phosphatidate phosphatase PAH2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070567 (cytidylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0046470 (phosphatidylcholine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046486 (glycerolipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0045017 (glycerolipid biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0008654 (phospholipid biosynthetic process), GO:0006656 (phosphatidylcholine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)