Protein: LITAF domain-containing protein (NMDA-type ionotropic glutamate receptor NMR-1) (G5EGQ9)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034100}. Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}.
Sequence: MFRISVIFIWIFLQLGYTIDYKVSVLIVSEPNQETFKELKVSVTAAFVEVFGSTSYHLGNDTISAAFVDAKSGDNRLELTQDIVCSQMLNHSLASVIFSPLLTSSSRFIDLVTSSAYTLSFYKLPVVGVMVRDAEFSKKNIYPTFVRPTAPLSDEAFVFLHMLLSLKYRQVVVLSVKRDINADQFVEEFEKRRVEFKIIVQRYIEVELNENLNDTLAESFEEVTSNIIVLFAKKDDAVRIFANAGDLTGKGKVWIVSESAGEAHNVPNGSLGCRLGQTAFSVLRDSFSILKSAMETIFRESKIDIFPPVECDRDSVDAEWNSLQAPALLNEICGTSTSRVHFNDKCERIGVEYDIINFHMERKQVGNMVGDILRLDEDSIEWAGGTKPLEISLPKHLRVVTVADPPFVYTTPIGSPSQCAELGNTVVEWSIFDKIVVSGPWYSCPLTLENSTEYFCCAGLAIDLLSNLSLPEANNSIDTSFTFSLHLNESYGVVQASETTGITISGVIGELDGDTADMAIGGITINPERERIVDFTEPWLYHGIRILEKNIPRDSPMQSFLQPLQSSLWTALFISVILVGLAIYCLDFKSPFERFYQADKEMEQDLKKEFELWIGKDADENVNFGEAMWFVWGVLLNSGVSEKTPRSCSARVLGIVWCGFCMIMVASYTANLAAFLVLDQPEKGLTGVTDPRLRNPSANFSFGTVLNSNVYQYFKRHVELSSMFRKMEPHNVRRASEAVHSLLNGSLDAFIWDSTRLEFEAARHCELRTRGSLFGRSAYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQKWIDRGGPNCVVEAHKSPARLGLVNMKDIFILVSSGVALGIFLSFVEVSYGRRLADKGRRRRIVTRYFQKWHDLTLGKKRRPYRLKYNLDRMIVRRGFSGLERCSFQELRERRQIRGLPTSKVDPYCFWPDLDFKDKPLVLFCSRCRNIVESDVHRETGLFAFLSCFLFAILFLWPCSPLPCFLSSFSDFVHICPLCSHIMGRFRRARSTRFYV
InterPro domains: - IPR001508: Ionotropic glutamate receptor, metazoa (family) [568-861]
- IPR001320: Ionotropic glutamate receptor, C-terminal (domain) [434-847]
- IPR015683: Ionotropic glutamate receptor (family) [127-863]
- IPR001828: Receptor, ligand binding region (domain) [117-264]
- IPR019594: Ionotropic glutamate receptor, L-glutamate and glycine-binding domain (domain) [451-549]
- IPR006629: LPS-induced tumour necrosis factor alpha factor (domain) [929-1017]
- IPR049872: Glutamate [NMDA] receptor subunit 1-like, ligand-binding domain (domain) [394-822]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [95-389]
Interaction partners: - NMDA-type ionotropic glutamate receptor NMR-2
- Disks large homolog 1
- Calcium/calmodulin-dependent protein kinase type II
- Protein lin-2
- Probable vesicular glutamate transporter eat-4
- Glutamate receptor 1
- Rab-3-interacting molecule unc-10
- Nuclear hormone receptor family member fax-1
- Neuronal immunoglobulin domain-containing protein rig-3
- Neuronal calcium sensor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0008066 (glutamate receptor activity), GO:0004972 (NMDA glutamate receptor activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0004970 (ionotropic glutamate receptor activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0042330 (taxis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0003008 (system process), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0001101 (response to acid chemical), GO:0009967 (positive regulation of signal transduction), GO:0010035 (response to inorganic substance), GO:1901698 (response to nitrogen compound), GO:0007635 (chemosensory behavior), GO:0007611 (learning or memory), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:1901700 (response to oxygen-containing compound), GO:0050877 (nervous system process), GO:0009612 (response to mechanical stimulus), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0050890 (cognition), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007612 (learning), GO:0010226 (response to lithium ion), GO:1902531 (regulation of intracellular signal transduction), GO:0050850 (positive regulation of calcium-mediated signaling), GO:0050848 (regulation of calcium-mediated signaling), GO:0032026 (response to magnesium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)