Protein: Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase) (O14983)
Organism: Homo sapiens (Human)
Function: Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04191}.
Sequence: MEAAHAKTTEECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNEAKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWLMVLKISLPVIGLDEILKFVARNYLEDPEDERRK
InterPro domains: - IPR008250: P-type ATPase, A domain superfamily (homologous_superfamily) [132-237]
- IPR001757: P-type ATPase (family) [93-786]
- IPR005782: P-type ATPase, subfamily IIA, SERCA-type (family) [53-856]
- IPR023299: P-type ATPase, cytoplasmic domain N (homologous_superfamily) [356-602]
- IPR036412: HAD-like superfamily (homologous_superfamily) [587-749]
- IPR044492: P-type ATPase, haloacid dehalogenase domain (domain) [330-753]
- IPR018303: P-type ATPase, phosphorylation site (ptm) [351-357]
- IPR023214: HAD superfamily (homologous_superfamily) [346-745]
- IPR006068: Cation-transporting P-type ATPase, C-terminal (domain) [784-987]
- IPR004014: Cation-transporting P-type ATPase, N-terminal (domain) [3-77]
- IPR023298: P-type ATPase, transmembrane domain superfamily (homologous_superfamily) [2-992]
Interaction partners: - Sarcolipin
- Phospholamban
- Sarcoplasmic reticulum histidine-rich calcium-binding protein
- Ryanodine receptor 1
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
- Histone acetyltransferase KAT5
- Nuclear receptor ROR-alpha
- Myosin regulatory light chain 11
- Myosin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0140358 (P-type transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0044325 (transmembrane transporter binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019899 (enzyme binding), GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0046872 (metal ion binding), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015662 (P-type ion transporter activity), GO:0005388 (P-type calcium transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050801 (monoatomic ion homeostasis), GO:0050790 (regulation of catalytic activity), GO:0012501 (programmed cell death), GO:0044093 (positive regulation of molecular function), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0098660 (inorganic ion transmembrane transport), GO:0044092 (negative regulation of molecular function), GO:0044057 (regulation of system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0051098 (regulation of binding), GO:0055082 (intracellular chemical homeostasis), GO:0046907 (intracellular transport), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0098655 (monoatomic cation transmembrane transport), GO:0051100 (negative regulation of binding), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0071702 (organic substance transport), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0043393 (regulation of protein binding), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0055074 (calcium ion homeostasis), GO:0034976 (response to endoplasmic reticulum stress), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0043085 (positive regulation of catalytic activity), GO:0006812 (monoatomic cation transport), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0070588 (calcium ion transmembrane transport), GO:0008016 (regulation of heart contraction), GO:0045862 (positive regulation of proteolysis), GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress), GO:0051345 (positive regulation of hydrolase activity), GO:0006874 (intracellular calcium ion homeostasis), GO:0006816 (calcium ion transport), GO:1900120 (regulation of receptor binding), GO:0032091 (negative regulation of protein binding), GO:0010952 (positive regulation of peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:0030001 (metal ion transport), GO:1903779 (regulation of cardiac conduction), GO:0010950 (positive regulation of endopeptidase activity), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:2001056 (positive regulation of cysteine-type endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0016528 (sarcoplasm), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0016529 (sarcoplasmic reticulum), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane), GO:0098588 (bounding membrane of organelle)