Protein: Dynein regulatory complex protein 1 (P0DL09)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23354437}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:23427265, ECO:0000269|PubMed:25411337, ECO:0000269|PubMed:29167384}.
Sequence: MDELQSQTEREARILARRKRIQERLAALREGDHGGGKEGENKEEIGKGKQQIIESKRRLMRVKYRTDQDVSSVRVAGDDRENQHRIQEEQTRQDLRAKLLAEAEQSARQNAAVAMRWADLFSIEVPQDLYNEIESQRQACERIIASKDKLIGEIKGELKKKDDEFVKTLKRQAEDIDTLLQYMSRQFVEVQNAYKEELDEIENAFLQERSDLLESNRREMQELFDKRSRLEQDFMDRYLAAVEAYQSQLEGHRQMDAEEYHILKIRLETDIQNLEQHLEAMRATYQLNTEKLEYNYRVLKEREKENTQTIESQKKKLSRQRDILSSLKQRYAETDRRYRDDNMKLTDEYKRITEQFKDLQSKFRHFELVDTKKYKEVWGMKEADVAALVRQLLQADKVLHEQQLGWDWRPPDDAVFAPVHGDAGSGGGAAAAATGGAAGGAAAAGGVGPNGEEESEEDAAARVREAELAERLRDGRNWGALGLLCDEAGFLIDIKARNMIERLPKDEQGQVKAEAILRSLGIADGSAFDALLEALSADSNIELRAKGMVAPQGRGMAEEKSDRGGTAVLVHPDEAVRRLKAFVEVYGTGPSRGPGGGGGGGGGMSGPMRVQGAMRRAAEREQEFWSRMTHVISDKHTRVWGALEKQLEKYLALLQERAGSLRDVESLQHQNNELRALLNQYLSSRINDELQIPPTQII
InterPro domains: - IPR039750: Dynein regulatory complex protein (family) [7-696]
- IPR039505: Dynein regulatory complex protein 1/2, N-terminal (domain) [75-176]
- IPR029440: Dynein regulatory complex protein 1, C-terminal (domain) [623-682]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0007017 (microtubule-based process), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0007018 (microtubule-based movement), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0003341 (cilium movement), GO:0060285 (cilium-dependent cell motility), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0060294 (cilium movement involved in cell motility), GO:0070286 (axonemal dynein complex assembly), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)