Protein: Sodium channel regulatory subunit beta-1 (Q07699)
Organism: Homo sapiens (Human)
Function: Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
Subcellular location: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17928445, ECO:0000269|PubMed:19710327, ECO:0000269|PubMed:21994374, ECO:0000269|PubMed:29992740, ECO:0000269|PubMed:30190309, ECO:0000305|PubMed:8125980}; Single-pass type I membrane protein {ECO:0000269|PubMed:30190309, ECO:0000305|PubMed:8125980}. Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000250|UniProtKB:Q00954}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000250|UniProtKB:Q00954}.; SUBCELLULAR LOCATION: [Isoform 2]: Perikaryon {ECO:0000269|PubMed:14622265}. Cell projection {ECO:0000269|PubMed:14622265}. Secreted {ECO:0000269|PubMed:21994374}. Note=Detected on Purkinje cells and their cell projections and on neuronal cell projections. {ECO:0000269|PubMed:14622265}.
Sequence: MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [24-131]
- IPR027098: Sodium channel subunit beta-1/beta-3 (family) [5-218]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [27-124]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [20-151]
Interaction partners: - Sodium channel regulatory subunit beta-2
- Sodium channel protein type 4 subunit alpha
- Sodium channel protein type 5 subunit alpha
- Sodium channel protein type 9 subunit alpha
- Sodium channel protein type 3 subunit alpha
- Sodium channel regulatory subunit beta-4
- Sodium channel protein type 1 subunit alpha
- Sodium channel protein type 2 subunit alpha
- Sodium channel protein type 7 subunit alpha
- Sodium channel protein type 8 subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016247 (channel regulator activity), GO:0005515 (protein binding), GO:0099106 (ion channel regulator activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0044325 (transmembrane transporter binding), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017080 (sodium channel regulator activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005248 (voltage-gated sodium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0007154 (cell communication), GO:0086065 (cell communication involved in cardiac conduction), GO:0030048 (actin filament-based movement), GO:0051049 (regulation of transport), GO:0086019 (cell-cell signaling involved in cardiac conduction), GO:0032409 (regulation of transporter activity), GO:0098660 (inorganic ion transmembrane transport), GO:0044057 (regulation of system process), GO:0034762 (regulation of transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0051668 (localization within membrane), GO:0003013 (circulatory system process), GO:0003012 (muscle system process), GO:0003254 (regulation of membrane depolarization), GO:0002027 (regulation of heart rate), GO:0043270 (positive regulation of monoatomic ion transport), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0098655 (monoatomic cation transmembrane transport), GO:0010765 (positive regulation of sodium ion transport), GO:0008015 (blood circulation), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0006936 (muscle contraction), GO:0086091 (regulation of heart rate by cardiac conduction), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0001508 (action potential), GO:0051899 (membrane depolarization), GO:0098662 (inorganic cation transmembrane transport), GO:0003015 (heart process), GO:0070252 (actin-mediated cell contraction), GO:0022898 (regulation of transmembrane transporter activity), GO:0008104 (protein localization), GO:0043269 (regulation of monoatomic ion transport), GO:0060371 (regulation of atrial cardiac muscle cell membrane depolarization), GO:0072657 (protein localization to membrane), GO:0006812 (monoatomic cation transport), GO:0060047 (heart contraction), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0035725 (sodium ion transmembrane transport), GO:1990778 (protein localization to cell periphery), GO:0010959 (regulation of metal ion transport), GO:0006941 (striated muscle contraction), GO:0008016 (regulation of heart contraction), GO:0086001 (cardiac muscle cell action potential), GO:0072659 (protein localization to plasma membrane), GO:0086003 (cardiac muscle cell contraction), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0086010 (membrane depolarization during action potential), GO:0061337 (cardiac conduction), GO:1902305 (regulation of sodium ion transmembrane transport), GO:2000649 (regulation of sodium ion transmembrane transporter activity), GO:0060048 (cardiac muscle contraction), GO:0030001 (metal ion transport), GO:0002028 (regulation of sodium ion transport), GO:0086002 (cardiac muscle cell action potential involved in contraction), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0001518 (voltage-gated sodium channel complex), GO:0034703 (cation channel complex), GO:0034706 (sodium channel complex)