Protein: Serine/threonine-protein kinase KIC1 (EC 2.7.11.1) (Kinase that interacts with CDC31) (N-rich kinase 1) (P38692)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Protein kinase involved in morphogenesis and cell integrity.
Sequence: MTTKPQNSKQGLAEGEMDVSSLFKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAPKPSQNGGGDEAQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAEDNNEWATAQHDLFNYAYPDEDSYYFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNYTNSKYPSKMVAGTTNTSGTHTAGPMTSSKRLESKAPKQLLELFEDNEIITAENDVNTEAPKISKSISSLNAGNSSRDDFIPSISNEVNGNINNNKMRPHLPPLSSGNNYYSQSTPALPLLQTKFNKTSKGPPTSGLTTAPTSIEIEIPEELPNSALPTPASADPVLIPSTKARSSTVTAGTPSSSSSIQYKSPSNVPRRLTVSNNRPEHCPSTITNQKLGSAVASNSGISSTPNNSNNYNNNTDSENSRGSSGSNTANSTQMGITNPGNVTKLSTHKASSPSRPLFGVGTSPNRKPAGSPTQNIGHNSTHTNLAPPPTMKPMANSKDNKDILLQPLNSIPSSSTLNTISGNSSNNLTSSNYFSNEKEGSRVNGDFKRNNPNLKLQMPLPTPVVRNKLLDPNTATSQNNNGMPGSAGISTNENINQFGFNTSSASNIPVSMTPISEKHIDFGGKIKRSQSISNRKNSSASEHPLNILGSSVSGNVSGIGNNNVGSNNNSGPNNSVPLSANTGNTTIKANSTTIATSSSAAASTTAPISQQTIPSGTQFNHILSSAATAANSVNSLGFGMCPPPQSLQMEMFLDLESFLPGKQRRVDRKPQVLKELENLLQMFEEGLPCIEHALKEQLISTPIKDNEH
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [23-277]
- IPR050629: STE20/SPS1-related Proline-Alanine-rich Kinase (family) [19-717]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [140-152]
- IPR035062: Kic1p-like serine/threonine kinase, catalytic domain (domain) [21-295]
- IPR017441: Protein kinase, ATP binding site (binding_site) [29-52]
- IPR000719: Protein kinase domain (domain) [23-276]
Interaction partners: - Protein HYM1
- Leucine-rich repeat-containing protein SOG2
- CBK1 kinase activator protein MOB2
- Cell morphogenesis protein PAG1
- Serine/threonine-protein kinase CBK1
- Metallothionein expression activator
- Factor arrest protein 8
- Cell division control protein 31
- T-complex protein 1 subunit theta
- Factor arrest protein 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0071840 (cellular component organization or biogenesis), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0051647 (nucleus localization), GO:0007097 (nuclear migration), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0043408 (regulation of MAPK cascade), GO:0007029 (endoplasmic reticulum organization), GO:0048308 (organelle inheritance), GO:0099515 (actin filament-based transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0060187 (cell pole), GO:0043332 (mating projection tip), GO:0005935 (cellular bud neck), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0005934 (cellular bud tip), GO:0005937 (mating projection)