Protein: Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH1 (EC 2.1.1.368) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Protein SET DOMAIN GROUP 32) (Suppressor of variegation 3-9 homolog protein 1) (Su(var)3-9 homolog protein 1) (Q9FF80)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression.
Subcellular location: Nucleus. Chromosome, centromere. Note=Associates with centromeric constitutive heterochromatin.
Sequence: MERNGGHYTDKTRVLDIKPLRTLRPVFPSGNQAPPFVCAPPFGPFPPGFSSFYPFSSSQANQHTPDLNQAQYPPQHQQPQNPPPVYQQQPPQHASEPSLVTPLRSFRSPDVSNGNAELEGSTVKRRIPKKRPISRPENMNFESGINVADRENGNRELVLSVLMRFDALRRRFAQLEDAKEAVSGIIKRPDLKSGSTCMGRGVRTNTKKRPGIVPGVEIGDVFFFRFEMCLVGLHSPSMAGIDYLVVKGETEEEPIATSIVSSGYYDNDEGNPDVLIYTGQGGNADKDKQSSDQKLERGNLALEKSLRRDSAVRVIRGLKEASHNAKIYIYDGLYEIKESWVEKGKSGHNTFKYKLVRAPGQPPAFASWTAIQKWKTGVPSRQGLILPDMTSGVESIPVSLVNEVDTDNGPAYFTYSTTVKYSESFKLMQPSFGCDCANLCKPGNLDCHCIRKNGGDFPYTGNGILVSRKPMIYECSPSCPCSTCKNKVTQMGVKVRLEVFKTANRGWGLRSWDAIRAGSFICIYVGEAKDKSKVQQTMANDDYTFDTTNVYNPFKWNYEPGLADEDACEEMSEESEIPLPLIISAKNVGNVARFMNHSCSPNVFWQPVSYENNSQLFVHVAFFAISHIPPMTELTYDYGVSRPSGTQNGNPLYGKRKCFCGSAYCRGSFG
InterPro domains: - IPR025794: Histone H3-K9 methyltransferase, plant (family) [15-670]
- IPR046341: SET domain superfamily (homologous_superfamily) [371-669]
- IPR003105: SRA-YDG (domain) [206-361]
- IPR036987: SRA-YDG superfamily (homologous_superfamily) [194-380]
- IPR001214: SET domain (domain) [495-645]
- IPR051357: Histone-lysine N-methyltransferase SUVAR3-9 (family) [63-665]
- IPR015947: PUA-like superfamily (homologous_superfamily) [196-381]
- IPR003616: Post-SET domain (domain) [654-670]
- IPR007728: Pre-SET domain (domain) [386-492]
Interaction partners: - Calmodulin-lysine N-methyltransferase
- Histone H3-like 5
- Histone H3.1
- Histone H3-like 2
- Histone H3.3
- Histone H3-like 3
- Histone H3-like 1
- Histone H3-like 4
- Histone H3-like centromeric protein CENH3
- DNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:1901265 (nucleoside phosphate binding), GO:0000166 (nucleotide binding), GO:0008168 (methyltransferase activity), GO:0003677 (DNA binding), GO:0008327 (methyl-CpG binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:0040029 (epigenetic regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)