Protein: Solute carrier family 22 member 3 (O88446)
Organism: Rattus norvegicus (Rat)
Function: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter. Implicated in neuronal monoamine neurotransmitters cellular uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (By similarity). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier. Mediates the transport of polyamine spermidine and putrescine. Mediates the bidirectional transport of polyamine agmatine. Also transports guanidine. May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling
Subcellular location: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Mitochondrion membrane. Endomembrane system. Nucleus membrane. Nucleus outer membrane. Note=Localized to neuronal and glial plasma membranes. Localized to the luminal/apical membrane of ciliated and brush epithelial cells in the airway. Located to neuronal and glial endomembranes, including mitochondrial and nuclear membranes
Sequence: MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQVSTSNV
InterPro domains: - IPR004749: Organic cation transport protein/SVOP (family) [12-523]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [119-529]
- IPR005829: Sugar transporter, conserved site (conserved_site) [392-408]
- IPR005828: Major facilitator, sugar transporter-like (family) [151-522]
- IPR020846: Major facilitator superfamily domain (domain) [22-517]
Interaction partners: - Choline transporter-like protein 4
- Choline transporter-like protein 1
- Choline transporter-like protein 2
- Choline transporter-like protein 3
- High affinity choline transporter 1
- Solute carrier family 22 member 2
- Choline transporter-like protein
- Solute carrier family 22 member 1
- Multidrug and toxin extrusion protein 1
- Cation-independent mannose-6-phosphate receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015101 (organic cation transmembrane transporter activity), GO:0019534 (toxin transmembrane transporter activity), GO:1901618 (organic hydroxy compound transmembrane transporter activity), GO:0015203 (polyamine transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008504 (monoamine transmembrane transporter activity), GO:0015651 (quaternary ammonium group transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015296 (monoatomic anion:monoatomic cation symporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015370 (solute:sodium symporter activity), GO:0015377 (chloride:monoatomic cation symporter activity), GO:0015378 (sodium:chloride symporter activity), GO:0015373 (monoatomic anion:sodium symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015850 (organic hydroxy compound transport), GO:0015695 (organic cation transport), GO:0015697 (quaternary ammonium group transport), GO:0015844 (monoamine transport), GO:0015711 (organic anion transport), GO:0015846 (polyamine transport), GO:0015848 (spermidine transport), GO:0051937 (catecholamine transport), GO:0015872 (dopamine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0005886 (plasma membrane)