Protein: Ribosomal protein S6 kinase beta (EC 2.7.11.1) (Q9NAH6)
Organism: Caenorhabditis elegans
Function: Serine/threonine-protein kinase which regulates mRNA translation. Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection. May regulate these processes by preventing the activation of transcription factor hif-1. Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size. In addition required for sperm production and embryo viability. Involved in axon regeneration of PLM and ALM neurons by inhibiting growth cone formation early after axotomy and later by inhibiting axon extension. Functions in axon regeneration and lifespan probably by preventing aak-2/AMPK activation. Negatively regulates autophagy.
Subcellular location: Cell projection, axon {ECO:0000269|PubMed:24431434}. Perikaryon {ECO:0000269|PubMed:24431434}. Note=Enriched in the synaptic branch of PLM neurons. {ECO:0000269|PubMed:24431434}.
Sequence: MADVFEFELEGHESQASPQRHAYHYDNCTEIMEDDHMYSNVADGQISAPPPSSSYMEDPMMESIQLCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTTGSDNGQIFAMKVLQKATIVRNQKDTAHTKAERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRLTLPAYLSNEARDLIKKLLKRHVDTRLGAGLSDAEEIKSHAFFKTTDWNLVYARQLEAPFKPNIENDEDTSLFDARFTKMTPVDSPCETNFSLNGDNPFVGFTYVAPSVLEMMNKGGHGGISVAHLASSMSRAGAAKSPRKPGDPETASILHGGHSNLFGHGPNSEAPQAFGYGIGSQMTTTTAGGAGIQQPYQSFSGGYPEDDAMDTSTPRASESRETTTGNGSTTTTRPSNVGSSASTPIPLPKRVM
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [80-399]
- IPR000719: Protein kinase domain (domain) [83-344]
- IPR000961: AGC-kinase, C-terminal (domain) [345-415]
- IPR016238: Ribosomal protein S6 kinase (family) [1-529]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [206-218]
- IPR017441: Protein kinase, ATP binding site (binding_site) [89-115]
- IPR017892: Protein kinase, C-terminal (domain) [365-405]
Interaction partners: - Target of rapamycin homolog
- DAF-15
- Defective pharyngeal development protein 4
- Small ribosomal subunit protein eS6
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- Target of rapamycin complex subunit lst8
- 5'-AMP-activated protein kinase catalytic subunit alpha-1
- GTP-binding protein
- Serine/threonine-protein phosphatase 2A catalytic subunit
- cAMP-dependent protein kinase regulatory subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0019900 (kinase binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0008340 (determination of adult lifespan), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048583 (regulation of response to stimulus), GO:0065009 (regulation of molecular function), GO:0044238 (primary metabolic process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0010171 (body morphogenesis), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0050920 (regulation of chemotaxis), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0001558 (regulation of cell growth), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0051098 (regulation of binding), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0000902 (cell morphogenesis), GO:0048580 (regulation of post-embryonic development), GO:2000026 (regulation of multicellular organismal development), GO:0050922 (negative regulation of chemotaxis), GO:0031325 (positive regulation of cellular metabolic process), GO:0016358 (dendrite development), GO:0048640 (negative regulation of developmental growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0002164 (larval development), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0048581 (negative regulation of post-embryonic development), GO:0061062 (regulation of nematode larval development), GO:0032535 (regulation of cellular component size), GO:0030030 (cell projection organization), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0051246 (regulation of protein metabolic process), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0060284 (regulation of cell development), GO:0006796 (phosphate-containing compound metabolic process), GO:0051960 (regulation of nervous system development), GO:1902667 (regulation of axon guidance), GO:0048666 (neuron development), GO:0036211 (protein modification process), GO:0061387 (regulation of extent of cell growth), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:0043412 (macromolecule modification), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0031346 (positive regulation of cell projection organization), GO:0030536 (larval feeding behavior), GO:0051247 (positive regulation of protein metabolic process), GO:0030516 (regulation of axon extension), GO:0048813 (dendrite morphogenesis), GO:0002119 (nematode larval development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:0016310 (phosphorylation), GO:0007411 (axon guidance), GO:0050771 (negative regulation of axonogenesis), GO:0031175 (neuron projection development), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0051345 (positive regulation of hydrolase activity), GO:0031401 (positive regulation of protein modification process), GO:0048812 (neuron projection morphogenesis), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0061564 (axon development), GO:0008045 (motor neuron axon guidance), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0031396 (regulation of protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)