Protein: Ras-related protein Rab-6C (EC 3.6.5.2) (Rab6-like protein WTH3) (Q9H0N0)
Organism: Homo sapiens (Human)
Function: May be involved in the regulation of centrosome duplication and cell cycle progression.
Subcellular location: Nucleus {ECO:0000269|PubMed:16103095}. Cytoplasm {ECO:0000269|PubMed:16103095}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20064528}.
Sequence: MSAGGDFGNPLRKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIITLVGNRTDLADKRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSDIKLEKPQEQTVSEGGCSCYSPMSSSTLPQKPPYSFIDCSVNIGLNLFPSLITFCNSSLLPVSWR
InterPro domains: - IPR001806: Small GTPase (family) [9-249]
- IPR050227: Ras-related protein Rab (family) [13-186]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [3-179]
- IPR005225: Small GTP-binding domain (domain) [13-169]
Interaction partners: - Vacuolar protein sorting-associated protein 53 homolog
- Vam6/Vps39-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0044237 (cellular metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0061919 (process utilizing autophagic mechanism), GO:0033036 (macromolecule localization), GO:0009056 (catabolic process), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0044248 (cellular catabolic process), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0045184 (establishment of protein localization), GO:0006914 (autophagy), GO:0016236 (macroautophagy), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0016482 (cytosolic transport), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0006895 (Golgi to endosome transport), GO:0048193 (Golgi vesicle transport), GO:0033365 (protein localization to organelle), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0007033 (vacuole organization), GO:0007041 (lysosomal transport), GO:1905037 (autophagosome organization), GO:0006623 (protein targeting to vacuole), GO:0000045 (autophagosome assembly), GO:0006622 (protein targeting to lysosome), GO:0006892 (post-Golgi vesicle-mediated transport), GO:0072665 (protein localization to vacuole), GO:0061462 (protein localization to lysosome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)