Protein: Junction plakoglobin (Q6P0K8)
Organism: Rattus norvegicus (Rat)
Function: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Subcellular location: Cell junction, adherens junction {ECO:0000250|UniProtKB:P14923}. Cell junction, desmosome {ECO:0000269|PubMed:21617128, ECO:0000269|PubMed:26858265}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P14923}. Cell membrane {ECO:0000250|UniProtKB:P14923}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14923}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7}. Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (By similarity). {ECO:0000250|UniProtKB:P14923}.
Sequence: MEVMNLIEQPIKVTEWQQTYTYDSGIHSGVNTCVPSVSSKGLLDEDDTCGRQYTLKKTTTYTQGVPQSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLENVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYADDMDATYRPMYSSDVPLDPLDMHMDMDGDYPMDTYSDGLRPPYPAADHMLA
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [126-654]
- IPR013284: Beta-catenin (family) [1-710]
- IPR011989: Armadillo-like helical (homologous_superfamily) [124-676]
- IPR000225: Armadillo (repeat) [132-654]
Interaction partners: - Desmoplakin
- Cadherin-1
- Desmoglein 2
- Catenin beta-1
- Cadherin-2
- Desmocollin 2
- Cadherin-5
- Cadherin 3
- Lymphoid enhancer-binding factor 1
- Transcription factor 7 like 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0045294 (alpha-catenin binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0005102 (signaling receptor binding), GO:0045296 (cadherin binding), GO:0050998 (nitric-oxide synthase binding), GO:0035254 (glutamate receptor binding), GO:0035255 (ionotropic glutamate receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0008283 (cell population proliferation), GO:0048771 (tissue remodeling), GO:0014823 (response to activity), GO:0009892 (negative regulation of metabolic process), GO:0048583 (regulation of response to stimulus), GO:0051606 (detection of stimulus), GO:0048523 (negative regulation of cellular process), GO:0009581 (detection of external stimulus), GO:0098609 (cell-cell adhesion), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009582 (detection of abiotic stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0050906 (detection of stimulus involved in sensory perception), GO:0035295 (tube development), GO:0010035 (response to inorganic substance), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:1901698 (response to nitrogen compound), GO:0010605 (negative regulation of macromolecule metabolic process), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:1901652 (response to peptide), GO:0060562 (epithelial tube morphogenesis), GO:0055123 (digestive system development), GO:0032355 (response to estradiol), GO:0048732 (gland development), GO:0050982 (detection of mechanical stimulus), GO:0035272 (exocrine system development), GO:0061008 (hepaticobiliary system development), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0043434 (response to peptide hormone), GO:0022008 (neurogenesis), GO:0051592 (response to calcium ion), GO:0010243 (response to organonitrogen compound), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0071241 (cellular response to inorganic substance), GO:0033993 (response to lipid), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0014070 (response to organic cyclic compound), GO:0060429 (epithelium development), GO:1901701 (cellular response to oxygen-containing compound), GO:0048565 (digestive tract development), GO:0010629 (negative regulation of gene expression), GO:0031016 (pancreas development), GO:0007507 (heart development), GO:0060541 (respiratory system development), GO:0030879 (mammary gland development), GO:0071248 (cellular response to metal ion), GO:0071285 (cellular response to lithium ion), GO:0007494 (midgut development), GO:0001889 (liver development), GO:0046686 (response to cadmium ion), GO:0048699 (generation of neurons), GO:0009913 (epidermal cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0030018 (Z disc), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0099080 (supramolecular complex), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0043292 (contractile fiber), GO:0019897 (extrinsic component of plasma membrane), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070161 (anchoring junction), GO:0005886 (plasma membrane), GO:0099081 (supramolecular polymer), GO:0001533 (cornified envelope), GO:0016342 (catenin complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0005911 (cell-cell junction), GO:0099513 (polymeric cytoskeletal fiber), GO:0005856 (cytoskeleton), GO:0005912 (adherens junction), GO:0030057 (desmosome), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)