Protein: P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor) (Q99572)
Organism: Homo sapiens (Human)
Function: Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:28326637}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q64663}.
Sequence: MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
InterPro domains: - IPR027309: P2X purinoreceptor extracellular domain superfamily (homologous_superfamily) [53-327]
- IPR046815: P2X purinoreceptor 7, intracellular domain (domain) [400-592]
- IPR001429: P2X purinoreceptor (family) [7-355]
- IPR053792: ATP P2X receptor, conserved site (conserved_site) [249-275]
- IPR003050: P2X7 purinoceptor (family) [1-592]
Interaction partners: - P2X purinoceptor 4
- Pannexin-1
- P2X purinoceptor 1
- P2X purinoceptor 3
- P2X purinoceptor 6
- P2X purinoceptor 5
- Glutamate receptor ionotropic, NMDA 2A
- Glutamate receptor ionotropic, NMDA 1
- Glutamate receptor ionotropic, NMDA 2C
- Glutamate receptor ionotropic, NMDA 2D
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:0008289 (lipid binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0038023 (signaling receptor activity), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0042802 (identical protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0001530 (lipopolysaccharide binding), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0005216 (monoatomic ion channel activity), GO:0032555 (purine ribonucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0035381 (ATP-gated ion channel activity), GO:0004931 (extracellularly ATP-gated monoatomic cation channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:1905954 (positive regulation of lipid localization), GO:0023057 (negative regulation of signaling), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048871 (multicellular organismal-level homeostasis), GO:0051050 (positive regulation of transport), GO:0065008 (regulation of biological quality), GO:0019725 (cellular homeostasis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0001776 (leukocyte homeostasis), GO:0048523 (negative regulation of cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0001906 (cell killing), GO:0051234 (establishment of localization), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0002252 (immune effector process), GO:0065009 (regulation of molecular function), GO:0140352 (export from cell), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0009605 (response to external stimulus), GO:0009653 (anatomical structure morphogenesis), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0023051 (regulation of signaling), GO:0032963 (collagen metabolic process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0051602 (response to electrical stimulus), GO:0051047 (positive regulation of secretion), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0072593 (reactive oxygen species metabolic process), GO:0048513 (animal organ development), GO:0034103 (regulation of tissue remodeling), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0034220 (monoatomic ion transmembrane transport), GO:0001817 (regulation of cytokine production), GO:0045184 (establishment of protein localization), GO:0010876 (lipid localization), GO:0032892 (positive regulation of organic acid transport), GO:0051283 (negative regulation of sequestering of calcium ion), GO:0034104 (negative regulation of tissue remodeling), GO:0010035 (response to inorganic substance), GO:0099536 (synaptic signaling), GO:0002697 (regulation of immune effector process), GO:0042391 (regulation of membrane potential), GO:0032940 (secretion by cell), GO:0002443 (leukocyte mediated immunity), GO:0031668 (cellular response to extracellular stimulus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1903829 (positive regulation of protein localization), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:1905952 (regulation of lipid localization), GO:0051954 (positive regulation of amine transport), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0034641 (cellular nitrogen compound metabolic process), GO:0070169 (positive regulation of biomineral tissue development), GO:0043170 (macromolecule metabolic process), GO:0140353 (lipid export from cell), GO:0098542 (defense response to other organism), GO:0048872 (homeostasis of number of cells), GO:0006884 (cell volume homeostasis), GO:0003254 (regulation of membrane depolarization), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0006629 (lipid metabolic process), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0031325 (positive regulation of cellular metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0006810 (transport), GO:0097035 (regulation of membrane lipid distribution), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0045778 (positive regulation of ossification), GO:0001909 (leukocyte mediated cytotoxicity), GO:0023061 (signal release), GO:0002260 (lymphocyte homeostasis), GO:0009968 (negative regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0012501 (programmed cell death), GO:0002250 (adaptive immune response), GO:0032370 (positive regulation of lipid transport), GO:0009410 (response to xenobiotic stimulus), GO:0034405 (response to fluid shear stress), GO:0051282 (regulation of sequestering of calcium ion), GO:0098660 (inorganic ion transmembrane transport), GO:0048731 (system development), GO:0046649 (lymphocyte activation), GO:0006793 (phosphorus metabolic process), GO:0000902 (cell morphogenesis), GO:0031341 (regulation of cell killing), GO:0009887 (animal organ morphogenesis), GO:0070661 (leukocyte proliferation), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0071496 (cellular response to external stimulus), GO:0030278 (regulation of ossification), GO:0090066 (regulation of anatomical structure size), GO:1902074 (response to salt), GO:0009967 (positive regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0031343 (positive regulation of cell killing), GO:0006952 (defense response), GO:0001505 (regulation of neurotransmitter levels), GO:0010033 (response to organic substance), GO:0060249 (anatomical structure homeostasis), GO:0009991 (response to extracellular stimulus), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0002699 (positive regulation of immune effector process), GO:0001894 (tissue homeostasis), GO:0051222 (positive regulation of protein transport), GO:0009612 (response to mechanical stimulus), GO:1903532 (positive regulation of secretion by cell), GO:0035592 (establishment of protein localization to extracellular region), GO:0046683 (response to organophosphorus), GO:0048705 (skeletal system morphogenesis), GO:0030030 (cell projection organization), GO:0071705 (nitrogen compound transport), GO:2000193 (positive regulation of fatty acid transport), GO:0002703 (regulation of leukocyte mediated immunity), GO:0051246 (regulation of protein metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0051209 (release of sequestered calcium ion into cytosol), GO:0071702 (organic substance transport), GO:0032675 (regulation of interleukin-6 production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0043235 (receptor complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043228 (non-membrane-bounded organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0036019 (endolysosome), GO:0000323 (lytic vacuole), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0012506 (vesicle membrane), GO:0042581 (specific granule), GO:0030667 (secretory granule membrane), GO:0005774 (vacuolar membrane), GO:0010008 (endosome membrane), GO:0042582 (azurophil granule), GO:0031982 (vesicle), GO:0070013 (intracellular organelle lumen), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0035577 (azurophil granule membrane), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0098852 (lytic vacuole membrane), GO:0035579 (specific granule membrane), GO:0005766 (primary lysosome), GO:0005765 (lysosomal membrane)