wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Epididymis secretory protein Li 108 (V9HW56)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI
InterPro domains: - IPR014751: DNA repair protein XRCC4-like, C-terminal (homologous_superfamily) [202-248]
- IPR000533: Tropomyosin (family) [7-247]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0008307 (structural constituent of muscle), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0001503 (ossification), GO:0030154 (cell differentiation), GO:0001649 (osteoblast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0032432 (actin filament bundle), GO:0042641 (actomyosin), GO:0036379 (myofilament), GO:0030054 (cell junction), GO:0005615 (extracellular space), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0099080 (supramolecular complex), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0005865 (striated muscle thin filament), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0097517 (contractile actin filament bundle), GO:0001725 (stress fiber), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0030055 (cell-substrate junction), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0031982 (vesicle), GO:0005925 (focal adhesion), GO:1903561 (extracellular vesicle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: Phosphoprotein phosphatase (Q99YM9)
Organism: Streptococcus pyogenes serotype M1
Function: Not known
Sequence: MKISLKTDIGQKRSNNQDFINKFDNKKGITLVILADGMGGHRAGNIASEMTVTDLGREWVKTDFTELSQIRDWLFETIQSENQRIYDLGQSEDFKGMGTTVEAVALVESSAIYAHIGDSRIGLVHDGHYTLLTSDHSLVNELVKAGQITEEEAASHPQRNIITQSIGQASPVEPDLGVRVLEPGDYLVINSDGLTNMISNDEIVTILGSKVSLDEKNQEMIDLANLRGGLDNITIALVHNESEDVE
InterPro domains: - IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [1-243]
- IPR015655: Protein phosphatase 2C (family) [16-238]
- IPR001932: PPM-type phosphatase-like domain (domain) [1-240]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: FAD-dependent urate hydroxylase (EC 1.14.13.-) (EC 1.14.13.113) (Flavoprotein urate hydroxylase) (Q8PDQ6)
Organism: Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
Function: Catalyzes the hydroxylation of urate to 5-hydroxyisourate (HIU). Is likely to be involved in the urate degradation pathway to allantoin. Is slightly more efficient (about 2.6 times) with NADPH than NADH as the electron donor.
Sequence: MSLAQLEHALQHDLQRLAHGGEPWVRPRVHPAGHVYDVVIVGAGQSGLGAAFALQRERVHNVLVIDENPPGQEGPWVTYARMQTLRTPKQITSIDLGVPTLTFRAWWEAQHGAAGWDALDKIPRGTWMDYLRWYRAALRLPVRNATQLVRIEPDAAPGIHRLHLAMGAPLMARKIILATGIQGGGQWQVPEWITQALPAQRYAHTSGPIDYAALAGKRVGILGGGASAFDNACFALDQGVARAEVFVRRAALPRVNPIRHMEQAGIIPRFAALPDADKYRMMASFFGRNQPPTNDTFQRACAHAGFALHLDAPWLGVEEHNDVVVVRTPQGEHRFDFLAIATGLVTDPRLRPELAALSGRIACWADRYQAPPGQANPVLDAHPYLGPGFELLPRTPDDAAAVDGLFAFNYSALINHGLSAAALSGLKVALPRLARAVADQLFLDDRQAMVEAYLGYDQAEFVGQWPQPTQAVA
InterPro domains: - IPR050982: Auxin biosynthesis and cation transport (family) [38-252]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [26-429]
- IPR038732: FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like, FAD/NAD(P)-binding domain (domain) [39-181]
Interaction partners: - Hydroxylase molybdopterin-containing subunit
- Aldehyde oxidoreductase iron-sulfur-binding subunit PaoA
- Oxidoreductase
- Oxidoreductase
- Ferredoxin
- Oxidoreductase
- Hydroxylase large subunit
- Oxalurate catabolism protein HpxZ
- Serine-pyruvate aminotransferase
- NodB homology domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:1901265 (nucleoside phosphate binding), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen), GO:0071949 (FAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0120252 (hydrocarbon metabolic process), GO:0044248 (cellular catabolic process), GO:0120253 (hydrocarbon catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex)
Protein: Serine peptidase inhibitor, Kunitz type, 2 (F6QKA3)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MAQLCEPRRGRALLALLASLLLSGAQAASRDLDVHESCGVSKVVGKCRASIPRWWYNVTDGTCQPFVYGGCEGNGNNYPSKEECLDKCAGITENTIDGLARSSDGASALSVPRKQDSADLAGEIFNYEEYCVPKAVTGPCRAAFPRWYYDVEKNSCSSFIYGGCRGNKNSYLSQEACMQHCSGKQMYPFLTPGTKAVILVGLFIMVLILLLGSSMVFLIRMVRRKQERALRTVWSTADDKEQLVKNTCVL
InterPro domains: - IPR002223: Pancreatic trypsin inhibitor Kunitz domain (domain) [35-182]
- IPR020901: Proteinase inhibitor I2, Kunitz, conserved site (conserved_site) [66-177]
- IPR036880: Pancreatic trypsin inhibitor Kunitz domain superfamily (homologous_superfamily) [34-185]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation), GO:0071772 (response to BMP), GO:2000178 (negative regulation of neural precursor cell proliferation), GO:0071363 (cellular response to growth factor stimulus), GO:2000177 (regulation of neural precursor cell proliferation), GO:0071773 (cellular response to BMP stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Dihydroneopterin triphosphate 2'-epimerase (EC 5.1.99.7) (D-erythro-7,8-dihydroneopterin triphosphate epimerase) (A0A0H2ZEG5)
Organism: Pseudomonas aeruginosa (strain UCBPP-PA14)
Function: Not known
Sequence: MPRLEPGMARIRVKDLRLRTFIGIKEEEILNKQDVLINLTILYPAADAVEVNDIEHALNYRTITKAIIRHVEENRFALLERMTQEILDLVMENPAVRYAEVEVDKPHALRFAESVSITLAGHR
InterPro domains: - IPR043133: GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase (homologous_superfamily) [6-122]
- IPR006157: Dihydroneopterin aldolase/epimerase domain (domain) [8-121]
- IPR006156: Dihydroneopterin aldolase (family) [5-120]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0019751 (polyol metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0042559 (pteridine-containing compound biosynthetic process), GO:0034311 (diol metabolic process), GO:0046173 (polyol biosynthetic process), GO:0034312 (diol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: SUN domain-containing protein 5 (AtSUN5) (F4JPE9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Encodes a member of the mid-SUN subfamily of SUN-domain proteins. It is involved in early seed development and nuclear morphology. [TAIR].
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MARRGSCSTICLNEKLQRFRIVRISDKADNFNSRSGSFFERSISLVLLLWCFLFLVYSKLGQSHDDYGNADRIGNYTDGSVSKTLNSTSSVFPQATEKENNFCLLRKGQLQDVYEHVLVNNALLICKVVLPERRISKKTLEARDPRYVNLEDKSLKVNGSSQLVNNGTRYRLEPDGNGYNYASAMKGAKVVDHNKEAKGASNVLGKDHDKYLRNPCSVSDKYVVIELAEETLVDTVRIANFEHYSSNPKEFSLSGSLSFPSDMWTPAGSFAAANVKQIQSFRLPEPKWLRYLKLNLVSHYGSEFYCTLSVVEVFGIDALEQMLEDLFVPSETPPSKPAMVELKTADEKQDGEIKSNRTDQIGKETEAQKKKDDVVKTINIIGDKKYEVKEKHNVLKVMMQKVKLIEMNLSLLEDSVKKMNDKQPEVSLEMKKTLVLVEKSKADIREITEWKGKMEKELRDLELWKTLVASRVESLARGNSALRLDVEKIVKEQANLESKELGVLLISLFFVVLATIRLVSTRLWAFLGMSITDKARSLWPDSGWVMILLSSSIMIFIHLLS
InterPro domains: - IPR045120: SUN domain-containing Suco/Slp1-like (family) [146-373]
- IPR012919: SUN domain (domain) [158-318]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [207-314]
Interaction partners: - SUN domain-containing protein 2
- SUN domain-containing protein 1
- Protein KAKU4
- TIR domain-containing protein
- Nuclear envelope-associated protein 1
- Protein CROWDED NUCLEI 1
- WPP domain-interacting tail-anchored protein 2
- Nuclear envelope-associated protein 3
- Protein CROWDED NUCLEI 4
- bZIP transcription factor 18
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0043621 (protein self-association)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0006997 (nucleus organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Alpha v integrin subunit variant (Integrin alpha V) (Integrin alpha-V isoform 1 preproprotein) (A2RQD8)
Organism: Sus scrofa (Pig)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
Sequence: MASLPRRRLRLRPRRLLLLLPGFLLPLCGAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSMFLLVGAPKANTTQPGIVEGGQVLKCDWSSHRGCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSKNIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPKVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQKASGNFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRPTGLNAVPSQILEGKWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAVLYRARPVITVNAGLEVYPSILNQDNKTCPLPGTDLKVSCFHVRFCLKADGKGTLPTKLNFQVELLLDKLKQKGAIRRALFLHNRFPGHSKNMTISRGGQMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYTTAADVTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYVGDDNPLTLIVKAQNQGEGAYEAELIVSIPPQADFIGVVRNSEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVQQQSEMDTSVKFDLQIQSSNLFDKVSPVVSYKVDLAVLAAVEIRGVSSPDHIFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLNLQWPYKYNNNTLLYILQYDIDGPMNCTSDMEINPLRIKISNSQTEKNDTVGGQGDRNHLVTKRDLTLIEGDVHTLGCGIAECLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDIFNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSET
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [625-763]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1014-1029]
- IPR000413: Integrin alpha chain (family) [248-1021]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [466-624]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [31-467]
- IPR013517: FG-GAP repeat (repeat) [252-405]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [468-995]
- IPR013519: Integrin alpha beta-propellor (repeat) [32-483]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [771-981]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0007229 (integrin-mediated signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protein delta homolog 1 (DLK-1) (Adipocyte differentiation inhibitor protein) (Preadipocyte factor 1) (Pref-1) [Cleaved into: Fetal antigen 1 (FA1)] (Q09163)
Organism: Mus musculus (Mouse)
Function: May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.
Subcellular location: Membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O70534}.
Sequence: MIATGALLRVLLLLLAFGHSTYGAECDPPCDPQYGFCEADNVCRCHVGWEGPLCDKCVTAPGCVNGVCKEPWQCICKDGWDGKFCEIDVRACTSTPCANNGTCVDLEKGQYECSCTPGFSGKDCQHKAGPCVINGSPCQHGGACVDDEGQASHASCLCPPGFSGNFCEIVAATNSCTPNPCENDGVCTDIGGDFRCRCPAGFVDKTCSRPVSNCASGPCQNGGTCLQHTQVSFECLCKPPFMGPTCAKKRGASPVQVTHLPSGYGLTYRLTPGVHELPVQQPEQHILKVSMKELNKSTPLLTEGQAICFTILGVLTSLVVLGTVAIVFLNKCETWVSNLRYNHTFRKKKNLLLQYNSGEELAVNIIFPEKIDMTTFNKEAGDEEI
InterPro domains: - IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [187-198]
- IPR001881: EGF-like calcium-binding domain (domain) [88-247]
- IPR051022: Notch Signaling and Cell Fate Determination (family) [29-282]
- IPR000742: EGF-like domain (domain) [22-247]
Interaction partners: - Neurogenic locus notch homolog protein 1
- CD209 antigen-like protein A
- Insulin-like growth factor 2
- Neurogenic locus notch homolog protein 2
- Retrotransposon-like protein 1
- Thyroxine 5-deiodinase
- Insulin-like growth factor-binding protein 1
- Growth factor receptor-bound protein 10
- Scm-like with four MBT domains protein 2
- Retrotransposon-derived protein PEG10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0045746 (negative regulation of Notch signaling pathway), GO:0008593 (regulation of Notch signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)
Protein: Protein BASIC PENTACYSTEINE1 (AtBPC1) (Q9SKD0)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcriptional regulator that specifically binds to GA-rich elements (GAGA-repeats) present in regulatory sequences of genes involved in developmental processes. Negatively regulates the homeotic gene AGL11/STK, which controls ovule primordium identity, by a cooperative binding to purine-rich elements present in the regulatory sequence leading to DNA conformational changes.
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MDDDGFRNWGYYEPAAASSFKGNLGLQLMSTIDRNTKPFLPGRESNLMIGSNGSYHSREQDMNYSWINQPKDNKFFNMLPISTPSYSNVLSETSGSNSIQMIHQPVLNSSRFEENPIPPPAPCEEQTGKKRKMRGSIATPTVPKAKKMRKPKEERDVTNNNVQQQQQRVKPVKKSVDLVINGVSMDISGLPVPVCTCTGTPQQCYRWGCGGWQSACCTTNISVYPLPMSTKRRGARISGRKMSQGAFKKVLEKLSTEGYSFGNAIDLKSHWARHGTNKFVTIR
InterPro domains: - IPR010409: GAGA-binding transcriptional activator (family) [1-283]
Interaction partners: - Polycomb group protein EMBRYONIC FLOWER 2
- Agamous-like MADS-box protein AGL11
- Telomere repeat-binding factor 1
- PLATZ transcription factor family protein
- Galactan beta-1,4-galactosyltransferase GALS1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)