Protein: Probable flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Gp48) (O64238)
Organism: Mycobacterium phage D29 (Mycobacteriophage D29)
Function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
Sequence: MKVQLIASTILEDPSWAGTDYVGDDETVTSADELAEFAGRNCYLSFDRPNPKTRENVDYLNHILDVGHESVLEHSSATFYIEASRSVLTELERHRHLSFSVVSQRYVDPTELGIHVPPAFTELSGSDADKAKEVLLDVQSFAQEAYEYLVHIFSDAGFPRKKAREAARAVLPNMTNSPMVVTGNHRAWRYVIKNRWHEAADAEIRELAGELLRQLREIAPNTYQDIPTEPYSYGG
InterPro domains: - IPR003669: Thymidylate synthase ThyX (family) [1-234]
- IPR036098: Thymidylate synthase ThyX superfamily (homologous_superfamily) [26-234]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0008168 (methyltransferase activity), GO:0070402 (NADPH binding), GO:0017076 (purine nucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019692 (deoxyribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0009262 (deoxyribonucleotide metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0009263 (deoxyribonucleotide biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0009394 (2'-deoxyribonucleotide metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0046385 (deoxyribose phosphate biosynthetic process), GO:0009162 (deoxyribonucleoside monophosphate metabolic process), GO:0009129 (pyrimidine nucleoside monophosphate metabolic process), GO:0009265 (2'-deoxyribonucleotide biosynthetic process), GO:0009124 (nucleoside monophosphate biosynthetic process), GO:0009219 (pyrimidine deoxyribonucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006221 (pyrimidine nucleotide biosynthetic process), GO:0009221 (pyrimidine deoxyribonucleotide biosynthetic process), GO:0009130 (pyrimidine nucleoside monophosphate biosynthetic process), GO:0009176 (pyrimidine deoxyribonucleoside monophosphate metabolic process), GO:0009157 (deoxyribonucleoside monophosphate biosynthetic process), GO:0009177 (pyrimidine deoxyribonucleoside monophosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)