Protein: BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2) (O95816)
Organism: Homo sapiens (Human)
Function: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release.
Sequence: MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKHATRIIDEVVNKFLDDLGNAKSHLMSLYSACSSEVPHGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSKTLQQNAESRFN
InterPro domains: - IPR003103: BAG domain (domain) [109-189]
- IPR037689: BAG family molecular chaperone regulator 2 (family) [5-196]
Interaction partners: - Heat shock cognate 71 kDa protein
- BAG family molecular chaperone regulator 1
- Heat shock 70 kDa protein 4
- E3 ubiquitin-protein ligase CHIP
- Heat shock protein 105 kDa
- BAG family molecular chaperone regulator 3
- Hsp70-binding protein 1
- BAG family molecular chaperone regulator 5
- Heat shock 70 kDa protein 4L
- Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0009894 (regulation of catabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:1903321 (negative regulation of protein modification by small protein conjugation or removal), GO:0031396 (regulation of protein ubiquitination), GO:0031397 (negative regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)