Protein: Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha) (P26992)
Organism: Homo sapiens (Human)
Function: Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1.
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Sequence: MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
InterPro domains: - IPR050379: Type I Cytokine Receptor (family) [41-346]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [106-304]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [31-112]
- IPR003961: Fibronectin type III (domain) [204-306]
- IPR003530: Long hematopoietin receptor, soluble alpha chain, conserved site (conserved_site) [202-244]
- IPR007110: Immunoglobulin-like domain (domain) [27-89]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [27-305]
- IPR003598: Immunoglobulin subtype 2 (domain) [37-96]
- IPR003599: Immunoglobulin domain subtype (domain) [31-106]
Interaction partners: - Ciliary neurotrophic factor
- Leukemia inhibitory factor receptor
- Interleukin-27 receptor subunit alpha
- Cardiotrophin-like cytokine factor 1
- Interleukin-6 receptor subunit beta
- Cardiotrophin-1
- Leukemia inhibitory factor
- Interleukin-11
- Interleukin-6 receptor subunit alpha
- Interleukin-6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007610 (behavior), GO:0042221 (response to chemical), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0003006 (developmental process involved in reproduction), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0061061 (muscle structure development), GO:0070997 (neuron death), GO:0012501 (programmed cell death), GO:0042127 (regulation of cell population proliferation), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0070887 (cellular response to chemical stimulus), GO:0048513 (animal organ development), GO:0007631 (feeding behavior), GO:0007166 (cell surface receptor signaling pathway), GO:0007548 (sex differentiation), GO:0010033 (response to organic substance), GO:0008284 (positive regulation of cell population proliferation), GO:0034097 (response to cytokine), GO:1901215 (negative regulation of neuron death), GO:0051402 (neuron apoptotic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0006915 (apoptotic process), GO:1901214 (regulation of neuron death), GO:0007517 (muscle organ development), GO:0019221 (cytokine-mediated signaling pathway), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0060538 (skeletal muscle organ development), GO:0043066 (negative regulation of apoptotic process), GO:0043523 (regulation of neuron apoptotic process), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)