Protein: Zinc transporter ZIP12 (A0A6I8PMZ8)
Organism: Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Function: Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent (By similarity). May play a role in neurulation and neurite extension (By similarity)
Subcellular location: Membrane; Multi- pass membrane protein. Note=At low Zn(2+) extracellular concentration, is redistributed from the perinuclear space to the cytoplasm and plasma membrane
Sequence: MFKWKKSLFWRIPVFFTFGALFVCAESRHKDNKQPPSQGGLLQALYSLNSANGTFLHKNNSTDIISLLLEKVECPKNVHGKQDPCTQCLRPDALLFMVGINKSSDIDDDAIQKISVVLLFYIMNQKDFCTSISNLTKMDYKFYRNSLLKLRKDEDCHYLSLNEIDDILSVSKQYFQLLEEKQCTDVISMEDAFAMVGSTAVDEIKLPRLAEIILTLSLQRVCITRKQFPNAEFFTDFIFQSFNRTNDLYAPDIAELIGELKATGDCSKLSNRRKSVRSVIPQKDNELLSNTNEEKGHDHSDIYEVEAHSRYWHQTHSCFSVYELVKVFFKNSHSPVSKEQFKQISPAIIHQLLTCSCPPASNGTTRLAPPTTLEKYGYSTISVLLLTIGSMFGATLIIFSSCEENYKLILQLFVGLAVGTLSGDALLHLIPQVLGVHEVVTHEHHMQQGDYIFEENEYLWKIMGMIGGIYGFFLINKLFFLLVSSPKQGLSLMNGHLTHSHDLPLDAHLGDQSRKAKSSSTIQLRSPDDCEHSEVPETLPVRPKARRKSKGISLLAIMILVGDSLHNFADGMVIGSAFSSSTETGIASTVAILCHEIPHEMGDFAVLLNTGLSAKIAFLMNFISALTAFAGLYIGLSLSANPDVQIWIFAVTAGMFLYLSLVEMLPEMIHVQTQRPWLMFFLQNLGLLLGWLCLLLLAIYEHKIQF
InterPro domains: - IPR003689: Zinc/iron permease (family) [378-698]
- IPR049406: Zinc transporter ZIP4/12, EF-hand (domain) [232-354]
- IPR050799: Zinc Iron Protein (ZIP) Transporter (family) [261-706]
- IPR041137: Zinc transporter ZIP4, N-terminal (domain) [64-223]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005381 (iron ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0120127 (response to zinc ion starvation), GO:0034224 (cellular response to zinc ion starvation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)