Protein: Cell wall protein RBT1 (Q59TP1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein required for mating efficiency, biofilm formation, and virulence. Involved in normal disseminated infection, but not in intestinal colonization
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
Sequence: MRFATAQLAALAYYILSTEATFPLLGDIFNCIPHNTPPVCTDLGLYHDSSISLGGSKNKREAEIANKDGTIEKRTFGSAGVNAGFNAAFVVSNAKKLSDGSYGIDCNFKSDSSVQLNSAFGKKVKQLSITGTGYSDISLLGNVANPFEWSASLKVKAEIVKGKCCLPSGFRIVTDFESNCPEFDAIKQFFGSSQIIYKVNAVSNAIGTFDASALFNAQVKAFPAKRELDEFEELSNDGVTHSKRTLGLLLGLLKKVTGGCDTLQQFCWDCQCDTPSPSTTTVSTSSAPSTSPESSAPSTTTVTTSSSPVTSPESSVPETTTVTTSSVPETTPESSAPETTTVTTSSVPSTTPESSAPETTPESSAPESSVPESSAPETTPESSAPESSVPESSAPETETETTPTAHLTTTTAQTTTVITVTSCSNNACSKTEVTTGVVVVTSEDTIYTTFCPLTETTPVPSSVDSTSVTSAPETTPESTAPESSAPESSAPESSAPVTETPTGPVSTVTEQSKTIVTITSCSNNACSESKVTTGVVVVTSEDTVYTTFCPLTETTPATESASESSAPATESVPATESAPVAPESSAPGTETAPATESAPATESSPVAPGTETTPATPGAESTPVTPVAPESSAPAVESSPVAPGVETTPVAPVAPSTTAKTSALVSTTEGTIPTTLESVPAIQPSANSSYTIASVSSFEGAGNNMRLTYGAAIIGLAAFLI
InterPro domains: - IPR025928: Flocculin type 3 repeat (repeat) [415-552]
- IPR018789: Flocculin 11 domain (domain) [55-278]
Interaction partners: - Extent of cell elongation protein 1
- Agglutinin-like protein 3
- Hyphal wall protein 1
- Induced during hyphae development protein 1
- Hyphally regulated cell wall protein 1
- Hypha-specific G1 cyclin-related protein 1
- Transcriptional regulatory protein UME6
- pH-responsive protein 1
- Agglutinin-like protein 1
- Transcriptional regulator DEF1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0051701 (biological process involved in interaction with host), GO:0098630 (aggregation of unicellular organisms), GO:0090609 (single-species submerged biofilm formation), GO:0031589 (cell-substrate adhesion), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:0042710 (biofilm formation), GO:0043708 (cell adhesion involved in biofilm formation), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0043230 (extracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0009277 (fungal-type cell wall), GO:0030446 (hyphal cell wall), GO:1903561 (extracellular vesicle), GO:0030445 (yeast-form cell wall)