Protein: Guanylate-binding protein 4 (EC 3.6.5.-) (Novel protein similar to vertebrate guanylate nucleotide binding protein family) (Q5RJ11)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}.
Sequence: MDKPVCLIDTGSDGKLCVQQAALQVLQQIQQPVVVVAVVGPYRTGKSFLMNRLAGKRTGFALSSNIKPKTEGIWMWCVPHPTKAGTTLVLLDTEGLGDVEKGDSKRDTYIFSLTVLLSSTLVYNSWGTIDNLAIEQLQYVTELIEHIKVTPDEDADDCAEFAKFFPHFIWCLRDFTLELKLDGKDLTEDEYLEFALKLRPGTSKKVMMYNLPRECIRKFFPCRTCFTFPSPTTPEKRSILESLSPAEFSPEFLEVTKRFCKFVFDRSEVKQLKGGHTVTGRVLGNLTKMYVDTISSGAVFCLENAVIAMAQIENEAATQEGLEVYQRGMEKLKSSFPLELEQVSSEHQRLSRMATQAFMARSFKDTDGKHLKALEGEIGKLFDAYRSQNKQVGLETHCDLLLYMRCKDPLILHVYFFPVNDARSKEKVEQNERSSLPISHPRPDRPFQVKTPHVLEVPGASVYPEEGISFRTDVEPNFFKVRKLQVDDVQMNLVRQKDKMSVWTTTIWKEEFVHLQQVRDERKLNSEIEKNDFFNAHRVAFIERVTNVKSIADKLHSQRIIHKELYSEITQTNVTRQQIMRKLCDSVDSSGRIAKCKFIDILQEEERCLLEDLKLSES
InterPro domains: - IPR011029: Death-like domain superfamily (homologous_superfamily) [532-618]
- IPR015894: Guanylate-binding protein, N-terminal (domain) [14-271]
- IPR001315: CARD domain (domain) [526-617]
- IPR033516: CARD8/ASC/NALP1, CARD domain (domain) [532-614]
- IPR036543: Guanylate-binding protein, C-terminal domain superfamily (homologous_superfamily) [274-396]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-273]
- IPR025307: FIIND domain (domain) [396-507]
- IPR030386: GB1/RHD3-type guanine nucleotide-binding (G) domain (domain) [30-268]
- IPR003191: Guanylate-binding protein/Atlastin, C-terminal (domain) [274-401]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097367 (carbohydrate derivative binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0001906 (cell killing), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0001776 (leukocyte homeostasis), GO:0048871 (multicellular organismal-level homeostasis), GO:0044403 (biological process involved in symbiotic interaction), GO:0002262 (myeloid cell homeostasis), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:0051702 (biological process involved in interaction with symbiont), GO:0009617 (response to bacterium), GO:0001780 (neutrophil homeostasis), GO:0006952 (defense response), GO:0002443 (leukocyte mediated immunity), GO:0001909 (leukocyte mediated cytotoxicity), GO:0098542 (defense response to other organism), GO:0048872 (homeostasis of number of cells), GO:0042742 (defense response to bacterium), GO:0002444 (myeloid leukocyte mediated immunity), GO:0051873 (killing by host of symbiont cells), GO:0002446 (neutrophil mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)