Protein: Paramyosin, long form (P35415)
Organism: Drosophila melanogaster (Fruit fly)
Function: Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
Subcellular location: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Sequence: MSSSQAVRSSKYSYRATSTGPGTADVNIEYIQDLSSLSRLEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLKLRKLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIESYNKEKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVSFSKSQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANADATSWQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDLEKSNNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQLTRENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADFNQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSLDVANKTNIDLQKVIKKQSLQLTELQAHYEDVQRQLQATLDQYAVAQRRLAGLNGELEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELRISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISKLEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYRRQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHRTFVTTSTVPGSQVYIQETTRTITE
InterPro domains: - IPR014751: DNA repair protein XRCC4-like, C-terminal (homologous_superfamily) [597-646]
- IPR002928: Myosin tail (domain) [37-853]
Interaction partners: - Myosin light chain alkali
- Tropomyosin-2
- Myosin heavy chain, muscle
- Troponin T, skeletal muscle
- Myosin regulatory light chain 2
- Troponin I
- Alpha-actinin, sarcomeric
- Trehalose 6-phosphate phosphatase
- Troponin C, isoform 2
- Bent, isoform F
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019900 (kinase binding), GO:0003779 (actin binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0032989 (cellular component morphogenesis), GO:0061061 (muscle structure development), GO:0044085 (cellular component biogenesis), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0016043 (cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0042692 (muscle cell differentiation), GO:0055001 (muscle cell development), GO:0007498 (mesoderm development), GO:0006996 (organelle organization), GO:0030239 (myofibril assembly), GO:0031032 (actomyosin structure organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0051146 (striated muscle cell differentiation), GO:0055002 (striated muscle cell development), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0031672 (A band), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0032982 (myosin filament)