Protein: Transcriptional activator plp-1 (Pur-alpha-like protein 1) (Q94230)
Organism: Caenorhabditis elegans
Function: Probable transcription activator. Binds telomeric DNA containing repeats of the sequence, 5'-TTAGGC-3'. Binds to end-1 promoter, activating end-1 expression, which is required for endoderm specification during embryonic development.
Subcellular location: Nucleus {ECO:0000269|PubMed:19084000}. Chromosome {ECO:0000269|PubMed:16267406, ECO:0000269|PubMed:19084000}. Note=localizes to nuclei of interphase cells throughout early embryogenesis. Localizes to the nucleus in a lit-1 dependent manner. Transiently asymmetrically localizes during telophase of the dividing EMS cell with higher levels in the future E cell nucleus and low or undetectable levels in that of the MS cell. {ECO:0000269|PubMed:19084000}.
Sequence: MSDGSVERGTKRAEDSLATHQLTVQYKRYYIDVNENTRGRYIKIAELGTNYKSRIILSIVAAKAIVSEISKMLALIDEPSTGEHAPKESSLIKSETLNVDGRKFYVDLKENVRGRFLRIAQMPMNPRQTRQQIAIPSDGIAEIHKVLTEYLAKFGEGHEQENTNTPKITAENKSFLFHSGKNDRGEFVRISEIKLNSGYRNAITVPMSALVDFRKELDNIIANQGK
InterPro domains: - IPR006628: Purine-rich element binding protein family (family) [11-225]
Interaction partners: - Multidrug resistance protein mrp-7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0043565 (sequence-specific DNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0032279 (asymmetric synapse)