wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: DUF4139 domain-containing protein (Q584R7)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSSVSSDHIELIPSLKGVTVFSDRAQLAFVASTALECGTHIIHLRPEGNWEDMITNTLLVKVQDGSNRHVAVHDVRLKHTDLTEEVREGVRVLKDSIDELQGKIDAVTDKKKVQSAVEAAVEKIEKKLMIMGERDCPSRAHKQLTDTTAITLFLSQPSSWMELICFISGRKRHVRECLLELKDEETKLQASLSKLQEELGEMQRGKRRQRRNTTVEVTLTVREQPTELKLNVSFVVTGASWKPLYDMRVSSSASTMDLTYYAQVQQRTPIDWNKVQLKVSTAAPHFGTQPPKLATWRISLKPPIANLKPRLLAMNLRGMPMPCAAKAVDTTDCNAAPREARVKQAIVSSSSPFSGAISSFHVLGLTTVRNNNRLVKVAIAKQTFPVELEYHAVPKSDKRVFRTAKAKNTSPYIFLPGKSHIFVDSTFMCGSRLDLVPAGADFSASLGADERVEVVRKEVKRTRSIVTRVVRSPLVRMDHVYEFSVKGTVQRETTLLVRDQCPLSPDDEVKVCVVEPSSKALKGRLTADGMKCAMDQMGMIEWKLKLSPGANNHVFRYAFQVEHPERLTVRGV
InterPro domains: - IPR011935: Conserved hypothetical protein CHP02231 (family) [6-571]
- IPR025554: Domain of unknown function DUF4140 (domain) [18-119]
- IPR037291: Domain of unknown function DUF4139 (domain) [230-565]
Interaction partners: - Nucleoside diphosphate kinase-like domain-containing protein
- Uncharacterized protein
- DNA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: DNA-directed RNA polymerase (EC 2.7.7.6) (Plastid-encoded RNA polymerase subunit alpha) (Q2LIP1)
Organism: Oryza punctata (Red rice)
Function: Not known
Subcellular location: Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Sequence: RVDSKRLYYGRFILSPLRKGQADTVGIALRRALLGETEGTCITHAKFGSVPHEYSTIAGIEESVQEILLNLKEIVLRSNLYGVRNASICVKGPRYITAQDIILPPSVEIVDTAQPIANLTEPEDFRIELRIKRDRGYHTEVRKNTQDGSYPIDAVSMPVRNVNYSIFSCGNGNAKYEILFLEIWTNGSLTPKEALYEASRNLIDLFLPFLHTEEEGTRFQENKNRFTSPLLSFQKRLTNLKKNKKRIPLNCIFIDQLELPSRTYNCLKRANIHTLLDLLSKTEEDLMRIDSFRMQDGKQIWDTLEKHLPMDLPKNKF
InterPro domains: - IPR011260: RNA polymerase, alpha subunit, C-terminal (domain) [247-305]
- IPR036603: RNA polymerase, RBP11-like subunit (homologous_superfamily) [2-211]
- IPR011262: DNA-directed RNA polymerase, insert domain (domain) [48-155]
- IPR011263: DNA-directed RNA polymerase, RpoA/D/Rpb3-type (domain) [9-212]
- IPR011773: DNA-directed RNA polymerase, alpha subunit (family) [4-315]
- IPR036643: DNA-directed RNA polymerase, insert domain superfamily (homologous_superfamily) [39-156]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Syntaxin 16 (A0A0G2K528)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004409}; Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004409}.
Sequence: MATRRLTDAFLLLRNNSIQNRQLLAEQVSSHTTSSPLHSRSIAAELDELADDRMALVSGISLDPEAAIGVTKRSPPKWVDGVDEIQYDVGRIKQKMRELASLHDKHLNRPTLDDSSEEEHAIEITTQEVTQLFHRCQRAVQALPSRARRTCSEQEERLLRNVVASLAQALQELSTSFRHAQSDYLKRMKNREERSQHFFDTPVPLMDDGDDATLYGQGFTDDQLVLVEQNTLVVEEREREIRQIVQSISDLNEIFRDLGAMIVEQGTVLDRIDYNVEQSCVKTEDGLKQLHKAEQYQKKNRKMLVILILVAVIVVLIVVLIAVKSR
InterPro domains: - IPR045242: Syntaxin (family) [92-312]
- IPR000727: Target SNARE coiled-coil homology domain (domain) [226-319]
- IPR010989: SNARE (homologous_superfamily) [74-286]
- IPR006012: Syntaxin/epimorphin, conserved site (conserved_site) [237-276]
Interaction partners: - Vesicle transport through interaction with t-SNAREs homolog 1A
- Vesicle-associated membrane protein 4
- Syntaxin-6
- Synaptobrevin homolog YKT6
- Vesicle-associated membrane protein 3
- Vacuolar protein sorting-associated protein 45
- Vesicle transport through interaction with t-SNAREs homolog 1B
- Syntaxin-8
- Synaptosomal-associated protein 29
- Alpha-soluble NSF attachment protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0051668 (localization within membrane), GO:0006810 (transport), GO:0016482 (cytosolic transport), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0032456 (endocytic recycling), GO:0042147 (retrograde transport, endosome to Golgi)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031201 (SNARE complex), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0070382 (exocytic vesicle), GO:0030672 (synaptic vesicle membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0099501 (exocytic vesicle membrane)
Protein: Enhancer of polycomb homolog (Q7ZUK6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU361124}.
Sequence: MSKLSFRARALDAAKPLPIYRNKDLPDLTDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQVFREKKESMVIPVPEAESNITYYDRLYKGEFRIPKQLIHIQPLGLDNELPDYDMDSEDETLLNRLNRKMELKPVQFETMMDRLEKASTNQLVTLQEAKLLLNEDDYLLKSVYDYWVRKRKNCRGPSLIPQIKQEKRDGSTNSDAYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRTISILEMIKKREKSKRELLHLTLEVFEKRYQIGDFTGEILNEVTVPLAEKTVYPAPISLPISSRHKTENKIKSHKIGPKHLHPFPVKPEPHFDFVRSHKKYNKRPKLDTFRQTGWPERIQTINKADIKQYDFHSSGEEDYPLSPASEPDEENDPDGVFAFRRKAGCSYHAPVVDQSCSPHWQQTGQDQLWQRNCLTALSVPRRCIAVACRRVGRGGRVVLDRTSSDLDHSLGHLDPDMLYPSAGSCVPDLPVHTNTNSHVSQRSLTQLLGDIQACRWKFFRPRPLQDNSRAEDKKGTPPVEKGGGTTLSNSVSGGFTEEQFQSHQQQLVHMHKQLQQQELQQNSTAAEAHLHLHTLDSAGAHFAASAVINTPNNENRPQIASVNGVLPNSGSFRQVKVNRSAPSGGGGAGGESGSLVRSPQLAVPQSLPHGHGHLSTVSAVSPAHTHHTARLCAPSPSALKLASVASSLDRVPKVTPTSAIDIARENHEPERLALNGLSETTVAMEVT
InterPro domains: - IPR019542: Enhancer of polycomb-like, N-terminal (domain) [7-148]
- IPR024943: Enhancer of polycomb protein (family) [1-616]
- IPR009607: Enhancer of polycomb, C-terminal (domain) [558-751]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0030097 (hemopoiesis), GO:0048568 (embryonic organ development), GO:0035162 (embryonic hemopoiesis), GO:0060215 (primitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0000785 (chromatin), GO:0044815 (DNA packaging complex), GO:1902494 (catalytic complex), GO:0000786 (nucleosome), GO:0031248 (protein acetyltransferase complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0000123 (histone acetyltransferase complex), GO:0043228 (non-membrane-bounded organelle), GO:1902493 (acetyltransferase complex), GO:1902562 (H4 histone acetyltransferase complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0043189 (H4/H2A histone acetyltransferase complex), GO:0035267 (NuA4 histone acetyltransferase complex)
Protein: C3H1-type domain-containing protein (Q57Y78)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MFLPEQSNIPGSVTYVSRAAGIPSSSTTQQYQGGECMGVPSELDAIDGGCAWRTASKGVCASQLPRGGSVAVSVSAPFIHLTDWGDATVSTREISDNAAEVPAARSIGNREGVDGSLTSSVFPSGDVNSTIDLPISLVNSALPNQEKNNMEFQDDCLAHVFSRPESPFKDFSAESEDPFTIMQTRSVTCNPNIWEVEGKDVQSSLIHDAVKVGMSQITPSLFSPITEAMESAIDKVKVAPDGLNDCRTVGPQQPTEEQRIPVVDPQRSKLHVPLSSIIPTKALGGRVSFPSLCLLFQSGRCLRGASCYQMHIDPQVVQRLRQINESLPYCCAFHGECNANKWDAEANAHRTILIKGAAVPLSRVAYTNGLERFVLKNNASRSLNTCAVCRLHGKPGGCRYGADCWYVHICRDVLKELVATIKLDLEDPGSEDQCKVPTKTESTGNRVVSGDLLGALSQQQNRRKQQNYPTVAFHPSKSPTMSHLHKGRSIVSSERDGTHSGKLSSHGSASTNTFSARASPTVGQITSDGTTCRNVLVQQRPPVYEDGPLGETRHGLATTMRLHGVAFPVTDPSEEKSVPSPSQFSLNDRQSVTPISGREVSTPSVPCCAMYFPQKQSSVAPCPQPMQNGHTVWPSTVLVPSTTVMYPMISATGLPVASAQQQMGTDGQTYGPFCFVSGREDGFRNLCLPMYGSGKGNMPSQVPLHVPF
InterPro domains: - IPR000571: Zinc finger, CCCH-type (domain) [292-411]
- IPR053125: RNA-binding mRNA stabilization regulator (family) [83-686]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Piercer of microtubule wall 1 protein (Pierce1) (p53-induced expression in RB-null cells protein 1) (Q5BN45)
Organism: Mus musculus (Mouse)
Function: Microtubule inner protein involved in the attachment of outer dynein arms (ODAs) to dynein-decorated doublet microtubules (DMTs) in cilia axoneme. Functions at the initial step of left-right asymmetry specification of the visceral organs.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q32P67}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}.
Sequence: MSEEKPQQSAEEPEPGEPKAKPAPEEPEPGEPKAKPAPEEPEPGEPKAKPAPEKTSDYYRISEKLPVRFNNPGWFHGYGTKEAVSMYRTSNQTYGSRAPTVHEMPKVFYPSSNKFSRQHAAFGMFQSHNINVTLEKSLVTGPDNHITHYDRLNFHPSYNVNRPSICD
InterPro domains: - IPR026507: Piercer of microtubule wall 1/2 (family) [1-148]
Interaction partners: - Tektin-1
- Calaxin
- Piercer of microtubule wall 2 protein
- EF-hand domain-containing family member C2
- Armadillo repeat-containing protein 3
- Cilia- and flagella-associated protein 161
- Cilia- and flagella-associated protein 90
- Tektin-3
- Tektin-4
- Cilia-and flagella-associated protein 96
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0007275 (multicellular organism development), GO:0048856 (anatomical structure development), GO:0048731 (system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0043073 (germ cell nucleus), GO:0001673 (male germ cell nucleus)
Protein: Interleukin-22 (Q198B4)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MSFSLMGTLAASCLLLVALWAQKADALPINSQCKLEAANFQQPYIVNRTFMLAKEASLADNNTDVRLIGEELFRGVKAKDQCYLMKQVLNFTLEDVLLPQSDRFQPYMQEVVPFLTKLSIHLSPCHISGDDQNIQKNVRQLKETVQKLGESGEIKAIGELDLLFMSLRNACV
InterPro domains: - IPR020453: Interleukin-22 (family) [1-172]
- IPR020423: Interleukin-10, conserved site (conserved_site) [77-97]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [22-172]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005125 (cytokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: PID domain-containing protein (B5BM46)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MNWIVHQQGSSNTMFYKCRPPIEFRFHKQTILGLKYDGLDRSSRSATSTIWVYDKCEFDNMIVPFMRHRPRNWDQESRYTAPRLMLCDTMSASQGNVFTRGLSRISRRKKKTKSIQNSLVSEQQPSFDAAIVPMPIPNDKSSIFSKGMDRLRRSLRLPKKRRDRSHDRHLSPDVTGGSKTEQWQPDEGAVRTGTCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQTIEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEETAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQSVIINEVPASNHMDEIRRISKPRPTGNPALFLRQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTERSPEKKSFGTQLYNEPIYEGDEDPLGLGITPPVVTKTSGSLSNNGLDGINLNWKSIPAPVHQMQQHNANGDFVAAWPQNTIEKPTVGPLDKLQKQFEDIKLISISSGENTPTTRSKADEWLDDVLRVSMSMSPTSPSSDPPSTSSYSVLPKSGPPPAHAPPPLPVRQAVSNGSPSIYQQQLQQANSTRNSPAGINWNSSPNPMKISQPPAKPVDPFDVQWSRLAVNNTH
InterPro domains: - IPR006020: PTB/PI domain (domain) [192-323]
- IPR016698: Numb/numb-like (family) [107-682]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [164-322]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051117 (ATPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0051668 (localization within membrane), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0015914 (phospholipid transport), GO:0032456 (endocytic recycling), GO:0015748 (organophosphate ester transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0055037 (recycling endosome), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240) (P86409)
Organism: Sus scrofa (Pig)
Function: Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q6GYP7}. Nucleus {ECO:0000250|UniProtKB:Q6GYP7}. Note=Translocated to the nucleus, when associated with TCF3/E12. {ECO:0000250|UniProtKB:Q6GYP7}.
Sequence: MFSKKPHGDVKKSTQKVLDTKKDALTRLKHLRIVIENAESIDLKQFFDQHFSHIYYVFFENFVTIEASLKQKGHKSQREELDAILFIFEKILQLLPERIHQRWQFHSIGLILKKLLHTGNSLKIRREGVRLFLLWLQALQNNCSREQLWMFSCLIPGFSAPQSEYGPRTLDNLINPPLNLQETQVTIEEITPLVPPQSGDKGQEDLTSYFLEALLKYIVIQVKSLEWKNKENQERGFSFLFSHFKKYYLPYIFPNICKENSLYHPVLDIPQMRPKPHYVMIKKDAETNEAIYCTKEPFIKARVIVIRWLVSFWLEPKPHTGPHIPGMEGEVLPKNIQ
InterPro domains: - IPR027107: Tuberin/Ral GTPase-activating protein subunit alpha (family) [1-310]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043409 (negative regulation of MAPK cascade), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Protein kintoun (Dynein assembly factor 2, axonemal) (B1H1W9)
Organism: Xenopus laevis (African clawed frog)
Function: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03069}. Dynein axonemal particle {ECO:0000269|PubMed:30561330, ECO:0000269|PubMed:33263282}. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. {ECO:0000255|HAMAP-Rule:MF_03069}.
Sequence: MAEKLQNLELSSEELDRFTKAFQDPKFREMFVQYAEEIRDPENRRKYEQEISQMESERGMDIKFIHPKPGYVLLTSVNGVQKCYLNICSNDLLQKPECKPGKDGEGKAGLHWSLPYSLSAGREDLGKDGSKHVIYDVVFHPDTLHIASKNEKFKMIVDSTSLEAVASQFDVKLDKANVRTLSMKYKGVPNPSVLRKPLLGTTPKHGDPEDPLSFPYPYDVPTAVGKEKKDQKRVIKEEHKQHVTTSEQDPDIQIATTPNYTVRHRSYVDLQDFRDSRDSTPSPVPKELVITVDLPLLNSAESVNLHIAGKNLSLESEKPAYKLNVKLPYVVEDNQGKAQFNKARRQLIITVPVIQHNILTLMQDHFEEARGEKDLRGAESSVLHEEYTDNGSRTSACGTENKLEPLISCLNEEENNSEGLTSESNLDTGAPYLPEISPNQNTLDREEVVYGLTEDVPSMPSDTLVCPTFSCSQDPTSLTLIAHVRDIDENSISTDVGSNHYHIRCSVKQSTSSYDLLVTFLPHDIINPNEVYVNISENNALIGLTKSPESVGFWKMLYFGVSGQPLQERRFVSEDNINEVLACSIPLSQVSPSTQEHQPLIEVLEMTDERTHIRINKPKTECVVSAEHKEHCTDHSEHERDVGVERSNIAVGDTTEHYSNQVSPCRENTELDRDHTSERYEEPESTSCTGESTSDQQQKDSNLVFPGDSSAENKMACLKSSEQTTQESDLAEDDMPDRSDHTQNFDSRPASSSVLKEIGKKDGSVQVISDHTTQCPFQFQNSLLFDLD
InterPro domains: - IPR050734: PIH1 family, Kintoun subfamily (family) [7-352]
- IPR041442: PIH1D1/2/3, CS-like domain (domain) [256-354]
- IPR012981: PIH1, N-terminal (domain) [38-198]
- IPR034727: Kintoun (family) [1-788]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0048870 (cell motility), GO:0007017 (microtubule-based process), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0030030 (cell projection organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0060285 (cilium-dependent cell motility), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0070286 (axonemal dynein complex assembly), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)