Protein: BTB/POZ domain-containing protein 3 (Q10225)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Sequence: MASQDQNTGTTHVELQGGENSKKLFSKYDLWSKAMDEKKLSSSLFTVNDTQEFLELCEACRRGDLEVVKSLVENYNTPINQVDQFDYSPLVLASLCGHEPVVKFLLENGALCERDTFQGERCLYGALNDNIRRMLLSYDITKAIDESQPYASHITSLLSNSALHFTTDIVFAGQYGRVFAHKFYLAARSSYFKSKFSKLGPSEHEIEVKHFAKEFESILRYLYLDTNAVFTKQYNNALLSIGKKFQLNDFIALYEKDREQLHSRDWKKIQLAKTQNDLGEFLDYIISNYKVPIESLNQPSDQYSFHDAYLQSYTHRYPVHRAIMCRCEYFLDMLAGPFLESNQELPVLSLPFSSSVVEIVLKFLYTDKTDIAPELALDVVYVADMLSLDKDRSLKSLASIVITKQEEPIDSIYDILRTAWDTSTPRLEQYASEYMANHLEHLIDDPEFCELVKESADRILQRQETDTIELIDDIRYFLSKRFGIYHEDLCIDGVVDTLTPYESEYNQKMEMIDDLLDKLELQA
InterPro domains: - IPR044515: Ankyrin repeat and BTB/POZ domain-containing protein 1-like (family) [47-523]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [36-323]
- IPR002110: Ankyrin repeat (repeat) [51-140]
- IPR000210: BTB/POZ domain (domain) [165-403]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [147-445]
Interaction partners: - Cullin-3
- BTB/POZ domain-containing protein 2
- BTB/POZ domain-containing protein 1
- Cullin-1
- RING-box protein pip1
- Elongin-C
- Cullin-associated NEDD8-dissociated protein 1
- Probable ubiquitin carboxyl-terminal hydrolase 12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0010467 (gene expression), GO:0042254 (ribosome biogenesis), GO:0042274 (ribosomal small subunit biogenesis), GO:0016070 (RNA metabolic process), GO:0090305 (nucleic acid phosphodiester bond hydrolysis), GO:0006396 (RNA processing), GO:0090501 (RNA phosphodiester bond hydrolysis), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0030490 (maturation of SSU-rRNA), GO:0006364 (rRNA processing), GO:0000460 (maturation of 5.8S rRNA), GO:0000469 (cleavage involved in rRNA processing), GO:0090502 (RNA phosphodiester bond hydrolysis, endonucleolytic), GO:0016072 (rRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing), GO:0000462 (maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000478 (endonucleolytic cleavage involved in rRNA processing), GO:0000447 (endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000466 (maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)), GO:0000479 (endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA))
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)