Protein: Mitogen-activated protein kinase (B6K0N4)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Sequence: MAEFVRTQIFGTCFEITTRYTDLQPIGMGAFGLVCSARDQLTGQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLRHENIISLSDIFISPFEDIYFVTELLGTDLHRLLTSRPLETQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYNVEVDIWSAGCIFAEMLEGKPLFPGRDHVNQFSIITELLGTPPDEVIETICSKNTLRFVQSLPKREKVPFSERFKNADPAAVDLLEKMLVFDPRKRISAADALAHEYLAPYHDPTDEPVAEEVFDWSFQDNDLPVETWKVMMYSEILSFHNVDSEVQA
InterPro domains: - IPR003527: Mitogen-activated protein (MAP) kinase, conserved site (conserved_site) [55-153]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [137-149]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [5-336]
- IPR017441: Protein kinase, ATP binding site (binding_site) [26-50]
- IPR038783: Mitogen-activated protein (MAP) kinase Sty1/HOG1 (family) [9-336]
- IPR008352: Mitogen-activated protein (MAP) kinase HOG-like (family) [184-308]
- IPR000719: Protein kinase domain (domain) [20-299]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [19-302]
Interaction partners: - Transcription factor prr1
- mitogen-activated protein kinase kinase
- Transcription factor
- Mitogen-activated protein kinase
- protein-tyrosine-phosphatase
- Transcription factor atf31
- Transcription factor Atf1
- Tyrosine phosphatase Pyp1
- Protein phosphatase 2C Ptc1
- Transcription factor Pcr1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:0045597 (positive regulation of cell differentiation), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0010570 (regulation of filamentous growth), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0071216 (cellular response to biotic stimulus), GO:0009891 (positive regulation of biosynthetic process), GO:0098542 (defense response to other organism), GO:0009991 (response to extracellular stimulus), GO:0010035 (response to inorganic substance), GO:2000026 (regulation of multicellular organismal development), GO:0042594 (response to starvation), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009617 (response to bacterium), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0090033 (positive regulation of filamentous growth), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0031347 (regulation of defense response), GO:0060421 (positive regulation of heart growth), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process), GO:0009267 (cellular response to starvation), GO:0000165 (MAPK cascade), GO:0010720 (positive regulation of cell development), GO:0002237 (response to molecule of bacterial origin), GO:0032104 (regulation of response to extracellular stimulus), GO:0010468 (regulation of gene expression), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0051149 (positive regulation of muscle cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0071243 (cellular response to arsenic-containing substance), GO:0071241 (cellular response to inorganic substance), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0030856 (regulation of epithelial cell differentiation), GO:0051403 (stress-activated MAPK cascade), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0019722 (calcium-mediated signaling), GO:0016310 (phosphorylation), GO:0071248 (cellular response to metal ion), GO:0032107 (regulation of response to nutrient levels), GO:0006275 (regulation of DNA replication), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071281 (cellular response to iron ion), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)