wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Clathrin light chain 1 (Q9SKU1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
Subcellular location: Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
Sequence: MATFDDGDFPAQTHSPSEHEDFGGYDNFSEAQQPPTQHQSGGFSSFNGDPASPNGYGFGASSPNHDFSSPFESSVNDANGNGGGSGGDAIFASDGPILPDPNEMREEGFQRREWRRLNTIHLEEKEKKEKEMRNQIITEAEDFKKAFYEKRDKTIETNKTDNREKEKLYWANQEKFHKEVDKHYWKAIAELIPREVPNIEKKRGKKDPDKKPSVNVIQGPKPGKPTDLGRMRQIFLKLKTNPPPHMMPPPPPAKDAKDGKDAKDGKDAKTGKDGKDAKGGKDAKDLKDGKPADPKVTEEKRPSPAKDASVETAKPDAAASGEGEKPVAVTEAEGTKAE
InterPro domains: - IPR000996: Clathrin light chain (family) [16-278]
Interaction partners: - Clathrin heavy chain 1
- AP-1 complex subunit sigma-2
- AP-2 complex subunit mu
- Phragmoplastin DRP1C
- AP-1 complex subunit mu-2
- At5g57460
- Probable protein phosphatase 2C 73
- AP-2 complex subunit sigma
- Protein TPLATE
- AP-1 complex subunit sigma-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0006970 (response to osmotic stress), GO:0009651 (response to salt stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Histidine-containing phosphotransfer protein (F4JGC7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU369004}. Nucleus {ECO:0000256|RuleBase:RU369004}.
Sequence: MGFGSLGMDLNWIGYFVGSSGFLGFLDDQFTELKKLQDDGSPDFVAEVLSLFFEDCVKLISNMARALDKSTGTVDFGQMKLFSCTLVFDTVLVRRGSKLCVLASRNIAKLRITKGKLVQHRLRTHRLRCLQQVDIEYKTLTTKLQDMFNLEKQIIQAGGRVPQVDIN
InterPro domains: - IPR036641: HPT domain superfamily (homologous_superfamily) [12-167]
- IPR045871: Histidine-containing phosphotransfer protein 1-5/Phosphorelay intermediate protein YPD1 (family) [24-154]
Interaction partners: - Putative two-component response regulator-like APRR6
- Putative two-component response regulator-like APRR4
- Putative two-component response regulator ARR19
- Putative two-component response regulator ARR21
- Two-component response regulator ARR18
- Putative two-component response regulator ARR13
- Two-component response regulator ARR14
- Two-component response regulator ARR11
- Putative two-component response regulator ARR20
- Two-component response regulator ARR2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0006996 (organelle organization), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0009657 (plastid organization), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0009658 (chloroplast organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Putative calcineurin B subunit (Q4QC21)
Organism: Leishmania major
Function: Not known
Sequence: MNEIPLTAEELQNIRESTALTDAQVQRLYKSFSKLNKDKSGKITRAEFNSIPALASNPLVDRVLAVMDTDGDSTVDFGDFVRALAVLSSATSKEDKLRFTFKMYDVDGDGRISNKDLFQMLSIMVGVNLSQMQLQQIVDKTFIEADVDRDGYITFEEFQALAVNSDFGDRLNLHF
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [9-162]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [105-158]
- IPR002048: EF-hand domain (domain) [23-168]
Interaction partners: - Putative serine/threonine protein phosphatase 2B catalytic subunit A2
- Serine/threonine-protein phosphatase
- Serine/threonine specific protein phosphatases domain-containing protein
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- peptidylprolyl isomerase
- peptidylprolyl isomerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043409 (negative regulation of MAPK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Multiple organellar RNA editing factor 4, mitochondrial (RNA editing-interacting protein 4) (O48582)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in organellar RNA editing. Required for the processing of few RNA editing site in mitochondria.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25583991}.
Sequence: MAMFSHRLRRIVVAAPSYFQRFSTLSRPSDFTPVPSLLPRSVVKQSTAINRSPARLFSTTQYQYDPYTGEDSFMPDNEGCDFNHWLITMNFPKDNLPSREEMISIFEQTCAKGLAISLEEAKKKIYAICTTSYQGFQATMTIGEVEKFRDLPGVQYIIPDSYIDVENKVYGGDKYENGVITPGPVPVPTKEGFDSLKKESKPEQEEAEIILTPPDEGKTSGQVQGQGSLTLPDQRSVKERQGTLALVQGQGQRSGMSILGQGQGEGRRMSIPGQWQSRGQGNSFQGSFKQSQGTLPVRKGQTQISDEIPSFQGNVKQRQEMPIHGQGQAQRSQMPSSQGTLRQGQAQGSQRPSNQVGYNQGQGAQTPPYHQGQGAQTPPYQESPNNYGQGAFVQYNQGPPQGNVVQTTQEKYNQMGQGNYAPQSGGNYSPAQGAGSPRFGYGQGQGGQLLSPYRGNYNQGQGTPLPGQGQEGQPSYQMGFSQGLGAPVPPNQVIPGNYGQWAFVNYNQGPPQGNFLQGPQQNHNQGGQWNYSPQNGGHYGPAQFGQWYPGPPQGQGIQWPQYQLSYNQGQGTPFSGQCRCPNCGMTSYQGYNNQGQGTHIPEQWEGQDYAVLSYQASYNQAHGAQAPPYHGNYNQATPGGYGQGTSANFNQRFPVNPANYNMQNGGNYGPPHGLAGNPGFRQGFSGQGQNQTFQQDDQRNVAGDLRNNNPVDPTETRKPNSRI
InterPro domains: - IPR039206: MORF/ORRM1/DAG-like (family) [4-338]
- IPR054059: MORF/ORRM1/DAG-like, MORF domain (domain) [82-175]
Interaction partners: - Protoporphyrinogen oxidase 1, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0016070 (RNA metabolic process), GO:0009451 (RNA modification), GO:1900864 (mitochondrial RNA modification), GO:0000959 (mitochondrial RNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Epididymis secretory sperm binding protein (A0A384MDN8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR
InterPro domains: - IPR036812: NAD(P)-dependent oxidoreductase domain superfamily (homologous_superfamily) [6-331]
- IPR050523: Aldo/Keto Reductase Detoxification and Biosynthesis (family) [12-328]
- IPR023210: NADP-dependent oxidoreductase domain (domain) [13-318]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0042802 (identical protein binding), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006081 (cellular aldehyde metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic (EC 1.2.1.12) (Q09054)
Organism: Zea mays (Maize)
Function: Key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Essential for the maintenance of cellular ATP levels and carbohydrate metabolism (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MGKIKIGINGFGRIGRLVARVALQSEDVELVAVNDPFITTDYMTYMFKYDTVHGQWKHSDIALKDSKTLLFGEKPVTVFGIRNPEEIPWGEAGAEYVVESTGVFTDKDKAAAHLKGGAKKVVISAPSKDAPMFVVGVNEDKYTSDVNIVSNASCTTNCLAPLAKVIHDNFGIIEGLMTTVHAITATQKTVDGPSAKDWRGGRAASFNIIPSSTGAAKAVGKVLPELNGKLTGMSFRVPTVDVSVVDLTVRIEKGASYEEIKKAIKAASEGPLKGIMGYVEEDLVSTDFTGDSRSSIFDAKAGIALNDHFIKLVSWYDNEWGYSNRVVDLIRHMFKTQ
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [3-169]
- IPR020828: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (domain) [4-154]
- IPR006424: Glyceraldehyde-3-phosphate dehydrogenase, type I (family) [5-328]
- IPR020831: Glyceraldehyde/Erythrose phosphate dehydrogenase family (family) [2-337]
- IPR020829: Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (domain) [159-316]
- IPR020830: Glyceraldehyde 3-phosphate dehydrogenase, active site (active_site) [152-159]
Interaction partners: - transketolase
- transketolase
- Phosphoglycerate kinase
- Phosphoglycerate kinase
- phosphoglycerate kinase
- Glucose-6-phosphate isomerase, cytosolic
- Phosphoglycerate kinase
- Triosephosphate isomerase, cytosolic
- transaldolase
- Glucose-6-phosphate isomerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0016491 (oxidoreductase activity), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0042301 (phosphate ion binding), GO:0070403 (NAD+ binding), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0017076 (purine nucleotide binding), GO:0043891 (glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity), GO:0030554 (adenyl nucleotide binding), GO:0004365 (glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity), GO:0051287 (NAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009314 (response to radiation), GO:0009416 (response to light stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like) (A4F267)
Organism: Rattus norvegicus (Rat)
Function: Potential channel-forming protein implicated in import of protein precursors into mitochondria.
Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:17437969}; Multi-pass membrane protein {ECO:0000269|PubMed:17437969}.
Sequence: MGNTLGLAPMGTLPRWSHRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHFQVAHTVHMSALGLPGYHLHTAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLRAKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSITHRLVLGGELVYHRRPGEEGAILTLAGKYSALHWVATLNVGSGGAHASYYHKANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQADMVFRGLVDSNWCVGAVLEKKMRPLPVTLALGAFLNHWRNRFHCGFSITVG
InterPro domains: - IPR037930: Tom40 (family) [20-308]
- IPR023614: Porin domain superfamily (homologous_superfamily) [16-307]
- IPR027246: Eukaryotic porin/Tom40 (family) [26-302]
Interaction partners: - Mitochondrial import receptor subunit TOM22 homolog
- Mitochondrial import receptor subunit TOM70
- Sorting and assembly machinery component 50 homolog
- Mitochondrial import receptor subunit TOM7 homolog
- Metaxin-1
- Translocase of outer mitochondrial membrane 5
- Mitochondrial import receptor subunit TOM40 homolog
- Superoxide dismutase
- Metaxin
- Mitochondrial import receptor subunit TOM20 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0006839 (mitochondrial transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0006626 (protein targeting to mitochondrion), GO:0070585 (protein localization to mitochondrion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)
Protein: Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) (Q803M6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR000929}.
Sequence: MVRWFHRDLSGLDAEAVLKSRGVHGSFLARPSKKNVGDFSLSVRVGEIITHIRIQNTGDYYDLYGGEKFATLAELVEYYTGDHGTLQDKDGTVIELKYPLNCSDPTTERWYHGHLSGPNAEKLLRERNEPGTFLVRESLSKPGDFVLSALTDDQTSSGRRVSHIKIMCNNDRYTVGGKDQFDNLTDLVEHFKRVGIEELSGTMVYLKQPYYSTRLNAADIQSRVNQLDQTSEREKMDGADKKIKAGFWEEFDALQKLETKVTKSRDEGMRPENKSKNRYKNILPFDETRVILENADPNVVGSDYINANYVINKLMVTNPQKTYIACQGCLATTVDDFWQMMWQEDSRVIVMTTREVEKGRNKCVPYWPTTEGESKEVGRYVVKLLSEMDAADYKVRVVELTAPHRNEAPRKIWHFQYLSWPDHGVPQEPGGVLSFLDQVNRKQEELRSSAPIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYKFIYLAVLQYVESTKVTRRAIMETETEYGNLSIQSKHPKASRKASSKKNEDVYENLGAKGKKDVKKQKSEEKKGGGSVRKR
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [212-522]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [433-509]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [411-517]
- IPR036860: SH2 domain superfamily (homologous_superfamily) [2-212]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [454-464]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [246-520]
- IPR052123: Non-receptor Tyrosine Phosphatase (family) [3-570]
- IPR000980: SH2 domain (domain) [2-210]
- IPR012152: Protein-tyrosine phosphatase, non-receptor type-6, -11 (family) [1-589]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: C-X-C motif chemokine 11 (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11) (Q9JHH5)
Organism: Mus musculus (Mouse)
Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity).
Subcellular location: Secreted.
Sequence: MNRKVTAIALAAIIWATAAQGFLMFKQGRCLCIGPGMKAVKMAEIEKASVIYPSNGCDKVEVIVTMKAHKRQRCLDPRSKQARLIMQAIEKKNFLRRQNM
InterPro domains: - IPR033899: CXC Chemokine domain (domain) [27-91]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [24-93]
- IPR001089: CXC chemokine (family) [29-86]
- IPR018048: CXC chemokine, conserved site (conserved_site) [30-76]
- IPR001811: Chemokine interleukin-8-like domain (domain) [27-89]
- IPR039809: Chemokine beta/gamma/delta (family) [10-92]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005126 (cytokine receptor binding), GO:0001664 (G protein-coupled receptor binding), GO:0005125 (cytokine activity), GO:0042379 (chemokine receptor binding), GO:0008009 (chemokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050900 (leukocyte migration), GO:0048870 (cell motility), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0002523 (leukocyte migration involved in inflammatory response), GO:0016477 (cell migration), GO:0006954 (inflammatory response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)