Protein: Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) (Q99623)
Organism: Homo sapiens (Human)
Function: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:28017329}. Cytoplasm {ECO:0000269|PubMed:17565718, ECO:0000269|PubMed:19496786, ECO:0000269|PubMed:32276428}. Nucleus {ECO:0000269|PubMed:17565718, ECO:0000269|PubMed:19496786, ECO:0000269|PubMed:20959514}. Cell membrane {ECO:0000269|PubMed:22997079, ECO:0000269|PubMed:24003225}. Note=Localizes within both nucleus and cytoplasm in proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. {ECO:0000269|PubMed:17565718}.; SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000305|PubMed:31522117}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion inner membrane {ECO:0000305|PubMed:31522117}.
Sequence: MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK
InterPro domains: - IPR001107: Band 7 domain (domain) [39-220]
- IPR000163: Prohibitin (family) [7-286]
- IPR036013: Band 7/SPFH domain superfamily (homologous_superfamily) [71-207]
Interaction partners: - Prohibitin 1
- Estrogen receptor
- Complement component 1 Q subcomponent-binding protein, mitochondrial
- Brefeldin A-inhibited guanine nucleotide-exchange protein 3
- Histone deacetylase 1
- Elongation factor Tu, mitochondrial
- Mitofusin-1
- Dynamin-like GTPase OPA1, mitochondrial
- Mitochondrial inner membrane m-AAA protease component AFG3L2
- Cytochrome b-c1 complex subunit 1, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0031625 (ubiquitin protein ligase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:0006970 (response to osmotic stress), GO:0010033 (response to organic substance), GO:0034097 (response to cytokine), GO:0047484 (regulation of response to osmotic stress), GO:0043069 (negative regulation of programmed cell death), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:2001233 (regulation of apoptotic signaling pathway), GO:1902531 (regulation of intracellular signal transduction), GO:0032526 (response to retinoic acid), GO:2001242 (regulation of intrinsic apoptotic signaling pathway), GO:0042981 (regulation of apoptotic process), GO:0036294 (cellular response to decreased oxygen levels), GO:0034612 (response to tumor necrosis factor), GO:1901222 (regulation of NIK/NF-kappaB signaling), GO:0043066 (negative regulation of apoptotic process), GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway), GO:0071345 (cellular response to cytokine stimulus), GO:0071474 (cellular hyperosmotic response), GO:0071354 (cellular response to interleukin-6), GO:0071356 (cellular response to tumor necrosis factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0019866 (organelle inner membrane), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane), GO:0005634 (nucleus)