Protein: 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPs) (P05466)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Subcellular location: Plastid, chloroplast {ECO:0000255}.
Sequence: MAQVSRICNGVQNPSLISNLSKSSQRKSPLSVSLKTQQHPRAYPISSSWGLKKSGMTLIGSELRPLKVMSSVSTAEKASEIVLQPIREISGLIKLPGSKSLSNRILLLAALSEGTTVVDNLLNSDDINYMLDALKRLGLNVETDSENNRAVVEGCGGIFPASIDSKSDIELYLGNAGTAMRPLTAAVTAAGGNASYVLDGVPRMRERPIGDLVVGLKQLGADVECTLGTNCPPVRVNANGGLPGGKVKLSGSISSQYLTALLMSAPLALGDVEIEIVDKLISVPYVEMTLKLMERFGVSVEHSDSWDRFFVKGGQKYKSPGNAYVEGDASSASYFLAGAAITGETVTVEGCGTTSLQGDVKFAEVLEKMGCKVSWTENSVTVTGPPRDAFGMRHLRAIDVNMNKMPDVAMTLAVVALFADGPTTIRDVASWRVKETERMIAICTELRKLGATVEEGSDYCVITPPKKVKTAEIDTYDDHRMAMAFSLAACADVPITINDPGCTRKTFPDYFQVLERITKH
InterPro domains: - IPR006264: 3-phosphoshikimate 1-carboxyvinyltransferase (family) [87-520]
- IPR013792: RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (homologous_superfamily) [81-517]
- IPR023193: 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site (conserved_site) [171-450]
- IPR001986: Enolpyruvate transferase domain (domain) [84-514]
- IPR036968: Enolpyruvate transferase domain superfamily (homologous_superfamily) [97-519]
Interaction partners: - Chorismate synthase, chloroplastic
- Shikimate kinase 1, chloroplastic
- Shikimate kinase 2, chloroplastic
- 3-dehydroquinate synthase, chloroplastic
- Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic
- Chorismate mutase 1, chloroplastic
- Chorismate mutase 2
- Chorismate mutase 3, chloroplastic
- Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0043650 (dicarboxylic acid biosynthetic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0046417 (chorismate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)