Protein: BBSome complex member bbs-7 (Bardet-Biedl syndrome 7 protein homolog) (Osmotic avoidance abnormal protein 12) (Q9XW70)
Organism: Caenorhabditis elegans
Function: Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in the removal of degraded mechanosensory receptors within the cilia. Plays a role in guanylyl cyclase localization in the ring-like structures at the base of the finger compartment in AFD sensory neurons. In ciliated sensory neurons, required for the sensation of nitric oxide and avoidance of NO-producing organisms like P.aeruginosa.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:15231740}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:15231740}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:15231740}. Note=Moves in anterograde and retrograde directions along the ciliary axonemes. {ECO:0000269|PubMed:15231740}.
Sequence: MQNYSRTDFAQVGTTNRGCMRVIPSDKEKEHDLIVVGGQNGSLICLSRKSNDTTIIFKTQPGYPVQSLALGGPASSKKKDKIFVASQNTVRGVNRKGKTFFSMETNMAEVANRMFVRGLDVVLTGRKSYSRYHDTVDSNSYLCTEDIHDVVSLVFEEAWGSREYTSILACGNSTLQIIEGNNFAYDVRLDSVPFTVSLFMGDGGHTKLLVLYGTKTGRLGLVSVPQGGGKILWEIDTTSGACVTTIVCFNVTGGQFPDIIVGKEDGLIEIYVIDETDHAHLFGTFSCDESITGISCGHVSSKSEIDIIICTFTGWLFSLAKTSRPMIENLPVAANFSVKMQQLRSEVEELQTKVNEERLRYEEITKRQGSGTGSTFFHSFQVHENFEYSAAHGAYNLTIELVIPIDFVVVQSQLPIRLMEVEKNASVVSEVRQDALNPWPLLASYRCQANVCRLELRVQANEGDSGVINLYVCPKVMPKCAQITTHYIKALSSHMRSHDFDLYRPMNTLQFTGNFSIAEAHAWLHNLLPNVPSKCPPADTITNNYQCSVNGGTQLQVVYSKGSAVFRSDCMTTICIIRDKVSEQTMKMQIRVEVACELNQDSVNHCLKLIDPKITSMLNIEKNKLYAAALKELESNNDDVFSFLSAANAKILKDHDAIYEKSEGVSIEDSGVLAILENLMVARGKLTGRSSKGRGDAIRDLISTDYSLENMQTLFKNAMND
InterPro domains: - IPR056333: BBS7, platform domain (domain) [494-597]
- IPR056335: BBS7, helical hairpin (domain) [601-715]
- IPR056334: BBS7, GAE domain (domain) [380-484]
- IPR016575: Bardet-Biedl syndrome 7 protein (family) [1-721]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [17-274]
- IPR056332: BBS7, beta-propeller (domain) [20-320]
Interaction partners: - BBSome complex member bbs-5
- BBSome complex member bbs-2
- BBSome complex member BBS1
- BBSome complex member bbs-4
- Protein pthb1 homolog
- Tetratricopeptide repeat protein 8
- Intraflagellar transport protein 88 homolog
- WD_REPEATS_REGION domain-containing protein
- Intraflagellar transport protein 52 C-terminal domain-containing protein
- WD repeat-containing protein dyf-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0033036 (macromolecule localization), GO:0045165 (cell fate commitment), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070727 (cellular macromolecule localization), GO:0007166 (cell surface receptor signaling pathway), GO:0060021 (roof of mouth development), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0042692 (muscle cell differentiation), GO:0042693 (muscle cell fate commitment), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0008104 (protein localization), GO:0007517 (muscle organ development), GO:0035051 (cardiocyte differentiation), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0033365 (protein localization to organelle), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048699 (generation of neurons), GO:0060538 (skeletal muscle organ development), GO:0050808 (synapse organization), GO:0061512 (protein localization to cilium), GO:0010975 (regulation of neuron projection development), GO:0097499 (protein localization to non-motile cilium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0036064 (ciliary basal body), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)