Protein: Lysine-specific histone demethylase (A0A0P0UQI8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity
Subcellular location: Chromosome. Nucleus
Sequence: MLSNKKSDPGSSSSSGGNGGDRAPETLAAPQAGPAGPSGPISADVKKKERASPSGEPGGPPLPHPPGPGGIDQDSAEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKERKQVIPPPAPPIEEENDSEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIINGPQHTQKVFLYIRNRTLQLWLDNPKVQLTFEATVQQLEAPYNSDAVLVHRIHSYLERHGFINFGIYKRVKPLPTKKTGKVIVIGAGVSGLAAARQLQSFGMDVTVLESRDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAGERCTSVPKEKDEMVEQEFNRLLEATSYLSHQLDFNFLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKDLLNKMVTTKEKVKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELVEMQVKLEERLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTSSGCEVIAVNTRSTTQTFIYKCDAVLCTLPLGVMKQQPPAVQFVPPLPEWKTAAIQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALMAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPAIPGASQPVPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTMPRQATANPNPQPSPSIQ
InterPro domains: - IPR017366: Lysine-specific histone demethylase (family) [60-816]
- IPR002937: Amine oxidase (domain) [259-802]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [142-248]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [143-248]
- IPR050281: Flavin monoamine oxidase and related enzymes (family) [178-811]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [247-820]
- IPR007526: SWIRM domain (domain) [145-244]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0032451 (demethylase activity), GO:0016491 (oxidoreductase activity), GO:0140457 (protein demethylase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0032452 (histone demethylase activity), GO:0032453 (histone H3K4 demethylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0002682 (regulation of immune system process), GO:0048856 (anatomical structure development), GO:0050793 (regulation of developmental process), GO:0007275 (multicellular organism development), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:1903706 (regulation of hemopoiesis), GO:2000026 (regulation of multicellular organismal development), GO:0080090 (regulation of primary metabolic process), GO:0010817 (regulation of hormone levels), GO:0032350 (regulation of hormone metabolic process), GO:0048731 (system development), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0046890 (regulation of lipid biosynthetic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0007399 (nervous system development), GO:0019747 (regulation of isoprenoid metabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0030656 (regulation of vitamin metabolic process), GO:0060284 (regulation of cell development), GO:0031326 (regulation of cellular biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)