Protein: Transcriptional regulator DEF1 (G1UB67)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional regulator involved in extension of germ tubes into elongated hyphae and maintenance of filamentous growth. Regulates expression of UME6. Acts in a pathway that regulates maintenance of hyphal growth by repressing hyphal-to-yeast transition and allows dissemination within host epithelial tissues. Dispensable for invasion into both host oral epithelial cells and enterocytes, but required for epithelial damage
Subcellular location: Nucleus
Sequence: MERRQFNTSNIRNGTGRPRKTPRSKLYMVYPPLSGEDSTNPEPEEGSSQENNPTEPSSSQSNSVQNQDQSEDQSQLPQQESNTQQESNTQQESNTPSPRASNTSTETPAPLSPIQPGIRNIPSGLLLPQEKVGRLMGYPFYRDFNFTLNPERYQKLIYVFQILKNAARNHRNGASLLRKYFSLARRSKRTTDMFVTTIEEMRKRSLENSRKRELEEAQEREESNKRQHTESSAEPNAESSTESTTESNAESGAEPNAEPSAESTTESNVESGAEPNAESGAESGAEPTAESNAELKQRIWEILSYRLEQSNNETNNTGESNSTSQQPRQLPNNELIMNIRVLQKNTHAKPVLGRIKFTPDKSNKTSLTGSQNKVHSTNTQQSQKHPQQILTNSETHKPQQYSAQSQQQMVHQTNSHEPSQKRSPPPQQQQQKQPSVPTSSVPLQVSQKQNQQQQELPLPPQPQPQQRTAPSAVKQQQSMQMQPPPQQQQQQQRHQPLQQSPPTMPLQQQPVPPVQQVQTVPPPSSQPQTQLSQQQQQQQQAQLQMQVPRCYQYQNRPPSQQRQYSQTPQYNQPPPQQKVYALPPQQVYAPPPRQVYAQPTIACKQQYPQQLYEQAPQEGSSYQHHYQQVQQRQNQQPYMQSAPTYQQPHVQTPKSTRSNKQEKQRLPKGQEQVPKATRTMFEAFTGSNIAVEKLRQRTLDNGREPERLRTEYVNVLSSPERAAEKSTSRSKQSSNQKPVVKQQSSFPPPIKHQQTQEQQGNILPPVSQLLAIQSSTVTSRGSNASGAVMGSGNTQRVASRSFTNTFVAEAVVNNANNRGGPVPPTGPETNTRGGRASTRSSGRPRGNRSTQRAEGNVTGRVARSTDGSQSQNSGKASKISNIRNLLN
Interaction partners: - Transcriptional regulatory protein UME6
- Histone acetyltransferase
- Transcriptional adapter 2
- Transcription initiation factor TFIID subunit 9
- Histone acetyltransferase
- Transcription initiation factor TFIID subunit 10
- Enhanced filamentous growth protein 1
- Deubiquitination module subunit
- Histone H4
- Hyphal wall protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0061733 (peptide-lysine-N-acetyltransferase activity), GO:0004402 (histone acetyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016407 (acetyltransferase activity), GO:0010485 (histone H4 acetyltransferase activity), GO:0016410 (N-acyltransferase activity), GO:0008080 (N-acetyltransferase activity), GO:0034212 (peptide N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0042594 (response to starvation), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0019538 (protein metabolic process), GO:0010570 (regulation of filamentous growth), GO:0044249 (cellular biosynthetic process), GO:0031668 (cellular response to extracellular stimulus), GO:0009268 (response to pH), GO:0044260 (cellular macromolecule metabolic process), GO:0071496 (cellular response to external stimulus), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009059 (macromolecule biosynthetic process), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:1901362 (organic cyclic compound biosynthetic process), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0036176 (response to neutral pH), GO:1900429 (negative regulation of filamentous growth of a population of unicellular organisms), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:0034645 (cellular macromolecule biosynthetic process), GO:0031669 (cellular response to nutrient levels), GO:0071467 (cellular response to pH), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0036244 (cellular response to neutral pH), GO:0042149 (cellular response to glucose starvation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)