Protein: Nicotianamine synthase 3 (EC 2.5.1.43) (S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-methionine 3-amino-3-carboxypropyltransferase 3) (AtNAS3) (O80483)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Synthesizes nicotianamine, a polyamine which serves as a sensor for the physiological iron status within the plant, and/or might be involved in the transport of iron.
Sequence: MGCQDEQLVQTICDLYEKISKLESLKPSEDVNILFKQLVSTCIPPNPNIDVTKMCDRVQEIRLNLIKICGLAEGHLENHFSSILTSYQDNPLHHLNIFPYYNNYLKLGKLEFDLLEQNLNGFVPKSVAFIGSGPLPLTSIVLASFHLKDTIFHNFDIDPSANSLASLLVSSDPDISQRMFFHTVDIMDVTESLKSFDVVFLAALVGMNKEEKVKVIEHLQKHMAPGAVLMLRSAHGPRAFLYPIVEPCDLQGFEVLSIYHPTDDVINSVVISKKHPVVSIGNVGGPNSCLLKPCNCSKTHAKMNKNMMIEEFGAREEQLS
InterPro domains: - IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [6-276]
- IPR004298: Nicotianamine synthase (family) [1-309]
Interaction partners: - Metal-nicotianamine transporter YSL1
- Ferric reduction oxidase 2
- Metal-nicotianamine transporter YSL3
- Ferritin-1, chloroplastic
- Ferric reduction oxidase 6
- Basic leucine zipper 19
- Probable metal-nicotianamine transporter YSL8
- Fe
- Ferric reduction oxidase 3, mitochondrial
- Fe
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0009856 (pollination), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0044706 (multi-multicellular organism process), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0016049 (cell growth), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0003008 (system process), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0009826 (unidimensional cell growth), GO:0006810 (transport), GO:0009860 (pollen tube growth), GO:0044249 (cellular biosynthetic process), GO:0048868 (pollen tube development), GO:0034641 (cellular nitrogen compound metabolic process), GO:0048229 (gametophyte development), GO:0003013 (circulatory system process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0003018 (vascular process in circulatory system), GO:1901362 (organic cyclic compound biosynthetic process), GO:0000904 (cell morphogenesis involved in differentiation), GO:0009555 (pollen development), GO:0010232 (vascular transport), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0009308 (amine metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0009932 (cell tip growth), GO:0019752 (carboxylic acid metabolic process), GO:0006576 (biogenic amine metabolic process), GO:0010233 (phloem transport), GO:0009309 (amine biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0042401 (biogenic amine biosynthetic process), GO:0072350 (tricarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)