Protein: Paired box 6b (Paired box protein Pax-6b isoform X1) (A0A0R4IQL7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
Sequence: MPQKEYHNQPTWESGVASMMQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQTHDDAKVQLDNKNVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVGKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQSGTWGTRPGWYPGTSVPGQPNQDGCQQQDNGGENTNSISSNGEDSDETQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNSSSHIPISSSFNTSVYQAIPQPTTPVSFTTGSMLGRPDTALTNTYTGLPPMPSFTMANNLPMQPSQTSSYSCMLPSSPSVNGRSFDTYTPPHMQAHMNSQTMATSGTASTGLISPGVSVPVQVPGTEPDMSQYWSRLQ
InterPro domains: - IPR001356: Homeodomain (domain) [240-304]
- IPR001523: Paired domain (domain) [23-163]
- IPR043565: PAX family (family) [18-417]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [25-301]
- IPR017970: Homeobox, conserved site (conserved_site) [275-298]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [16-169]
Interaction partners: - Achaete-scute homolog 1a
- Neurogenic differentiation factor 1
- Insulinoma-associated protein 1a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030902 (hindbrain development), GO:0031018 (endocrine pancreas development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0009887 (animal organ morphogenesis), GO:0021536 (diencephalon development), GO:0002088 (lens development in camera-type eye), GO:0009888 (tissue development), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0003002 (regionalization), GO:0002089 (lens morphogenesis in camera-type eye), GO:0030900 (forebrain development), GO:0061303 (cornea development in camera-type eye), GO:0021538 (epithalamus development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035270 (endocrine system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0007420 (brain development), GO:0003309 (type B pancreatic cell differentiation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0007399 (nervous system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0009952 (anterior/posterior pattern specification), GO:0031016 (pancreas development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0150063 (visual system development), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0043010 (camera-type eye development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0048593 (camera-type eye morphogenesis), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0002067 (glandular epithelial cell differentiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0035883 (enteroendocrine cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)