Protein: C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1) (Q9R007)
Organism: Mus musculus (Mouse)
Function: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.
Subcellular location: Cell membrane {ECO:0000269|PubMed:19074552}; Single-pass type II membrane protein {ECO:0000269|PubMed:19074552}.
Sequence: MNWHMIISGLIVVVIKVVGMTFFLLYFPQVFGKSNDGFVPTESYGTTSVQNVSQIFGRNDESTMPTRSYGTVCPRNWDFHQGKCFFFSFSESPWKDSMDYCATQGSTLAIVNTPEKLKYLQDIAGIENYFIGLVRQPGEKKWRWINNSVFNGNVTNQDQNFDCVTIGLTKTYDAASCEVSYRWICEMNAK
InterPro domains: - IPR052869: C-type lectin domain-containing protein 5A (family) [1-189]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [61-190]
- IPR016187: C-type lectin fold (homologous_superfamily) [61-189]
- IPR001304: C-type lectin-like (domain) [73-187]
- IPR033992: Natural killer cell receptor-like, C-type lectin-like domain (domain) [73-186]
Interaction partners: - TYRO protein tyrosine kinase-binding protein
- Hematopoietic cell signal transducer
- High affinity immunoglobulin epsilon receptor subunit gamma
- C-type lectin domain family 4 member A
- Tyrosine-protein kinase SYK
- Triggering receptor expressed on myeloid cells 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0006955 (immune response), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0031343 (positive regulation of cell killing), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0030522 (intracellular receptor signaling pathway), GO:0045087 (innate immune response), GO:0002218 (activation of innate immune response), GO:0098542 (defense response to other organism), GO:0031341 (regulation of cell killing), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0002833 (positive regulation of response to biotic stimulus), GO:0002697 (regulation of immune effector process), GO:0009617 (response to bacterium), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0009620 (response to fungus), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0071310 (cellular response to organic substance), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0042742 (defense response to bacterium), GO:0050832 (defense response to fungus), GO:0030101 (natural killer cell activation), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity), GO:0002223 (stimulatory C-type lectin receptor signaling pathway), GO:0002717 (positive regulation of natural killer cell mediated immunity), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0002715 (regulation of natural killer cell mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)