Protein: Uracil-DNA glycosylase (E5KTA5)
Organism: Homo sapiens (Human)
Function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Subcellular location: Mitochondrion. Nucleus
Sequence: MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGTPPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL
InterPro domains: - IPR018085: Uracil-DNA glycosylase, active site (active_site) [147-156]
- IPR002043: Uracil-DNA glycosylase family 1 (family) [42-312]
- IPR005122: Uracil-DNA glycosylase-like (domain) [139-301]
- IPR036895: Uracil-DNA glycosylase-like domain superfamily (homologous_superfamily) [80-312]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0044877 (protein-containing complex binding), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0043021 (ribonucleoprotein complex binding), GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds), GO:0043024 (ribosomal small subunit binding), GO:0003677 (DNA binding), GO:0019104 (DNA N-glycosylase activity), GO:0003684 (damaged DNA binding), GO:0097506 (deaminated base DNA N-glycosylase activity), GO:0004844 (uracil DNA N-glycosylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0033554 (cellular response to stress), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0019439 (aromatic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0019692 (deoxyribose phosphate metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0006259 (DNA metabolic process), GO:0009262 (deoxyribonucleotide metabolic process), GO:0046434 (organophosphate catabolic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0006304 (DNA modification), GO:0046386 (deoxyribose phosphate catabolic process), GO:0009117 (nucleotide metabolic process), GO:0006281 (DNA repair), GO:1901292 (nucleoside phosphate catabolic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0006285 (base-excision repair, AP site formation), GO:0009394 (2'-deoxyribonucleotide metabolic process), GO:0009264 (deoxyribonucleotide catabolic process), GO:0072529 (pyrimidine-containing compound catabolic process), GO:0006244 (pyrimidine nucleotide catabolic process), GO:0009219 (pyrimidine deoxyribonucleotide metabolic process), GO:0009166 (nucleotide catabolic process), GO:0006284 (base-excision repair), GO:0009223 (pyrimidine deoxyribonucleotide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)