Protein: Cytoplasmic polyadenylation element-binding protein 2 (CPE-BP2) (CPE-binding protein 2) (mCPEB-2) (Q812E0)
Organism: Mus musculus (Mouse)
Function: May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers. Required for cell cycle progression, specifically for the transition from metaphase to anaphase (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12672660}.
Sequence: MNLPQQQPPAAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQRNSYNHHQPLLKQSPWSNHQNSGWGTASMSWGAMHGRDHRRSGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPSLTPKSWIEDNVFRTDNNSNTLLPLQVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYDSLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGTDNLLMLNGRSSLFPIDDSLLDDGHSDQVGVLNSPTCYSAHQNGERIERFSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIHFRWN
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [263-432]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [264-449]
- IPR032296: Cytoplasmic polyadenylation element-binding protein, ZZ domain (domain) [445-507]
- IPR000504: RNA recognition motif domain (domain) [263-450]
- IPR034819: Cytoplasmic polyadenylation element-binding protein (family) [11-521]
- IPR038446: CEBP, ZZ domain superfamily (homologous_superfamily) [450-514]
Interaction partners: - Aurora kinase A
- Fragile X messenger ribonucleoprotein 1
- Cyclin-dependent kinase 1
- Serine/threonine-protein kinase PLK1
- G2/mitotic-specific cyclin-B2
- Polyadenylate-binding protein 1
- Elongation factor 2
- RNA-binding protein FXR1
- Y-box-binding protein 1
- RNA-binding protein FXR2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0001666 (response to hypoxia), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0070482 (response to oxygen levels), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0071456 (cellular response to hypoxia), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0034248 (regulation of amide metabolic process), GO:0010243 (response to organonitrogen compound), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071453 (cellular response to oxygen levels), GO:0051246 (regulation of protein metabolic process), GO:0071310 (cellular response to organic substance), GO:0036293 (response to decreased oxygen levels), GO:0051248 (negative regulation of protein metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:1901699 (cellular response to nitrogen compound), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:0017148 (negative regulation of translation), GO:1901653 (cellular response to peptide), GO:0036294 (cellular response to decreased oxygen levels), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0006417 (regulation of translation), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0010608 (post-transcriptional regulation of gene expression), GO:2000765 (regulation of cytoplasmic translation), GO:0032869 (cellular response to insulin stimulus), GO:2000766 (negative regulation of cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0097440 (apical dendrite), GO:0005634 (nucleus)