Protein: Sulfotransferase 2A1 (ST2A1) (EC 2.8.2.2) (Bile salt sulfotransferase 1) (EC 2.8.2.14) (Hydroxysteroid sulfotransferase) (ST) (P52843)
Organism: Mus musculus (Mouse)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q06520}.
Sequence: MMSDYNWFEGIPFPAISYQREILEDIRNKFVVKEEDLLILTYPKSGTNWLIEIVCLIQTKGDPKWIQTVPIWNRSPWIETDIGYSALINKEGPRLITSHLPIHLFSKSFFSSKAKAIYLVRNPRDILVSGYFFWGNTNLVKNPGSLGTYFEWFLKGNVLFGSWFEHVRGWLSMREWDNFLVLYYEDIKKDTKGTIKKICDFLGKNLGPDELDLVLKYSSFQAMKENNMSNFSLIKEDQVTNGLKLMRKGTIGDWKNHFTVAQAEAFDKVFQEKMAGFPPGIFPWE
InterPro domains: - IPR000863: Sulfotransferase domain (domain) [35-277]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-285]
Interaction partners: - Cytochrome P450 1A1
- Cytochrome P450 1B1
- Sulfotransferase
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
- Nuclear receptor subfamily 1 group I member 2
- Cytochrome P450 3A11
- UDP-glucuronosyltransferase 1A1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016740 (transferase activity), GO:1901681 (sulfur compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0008146 (sulfotransferase activity), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0006629 (lipid metabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0016054 (organic acid catabolic process), GO:0043436 (oxoacid metabolic process), GO:0008206 (bile acid metabolic process), GO:0008202 (steroid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)