Protein: Set1 complex component sdc1 (Set1C component sdc1) (COMPASS component sdc1) (Complex proteins associated with set1 protein sdc1) (Lid2 complex component sdc1) (Lid2C component sdc1) (O74861)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance.
Subcellular location: Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MSNSAPARQYLNEKVTPVLLEGMKILARDRPENPLQFLGQFLLDANANQQKQKEIVNQPEPQQETPKADADMSTPTMAEQVQTSFSNPASTPLTQTSSPSSNPGKNSAS
InterPro domains: - IPR049629: DPY30/SDC1, dimerization/docking domain (domain) [7-46]
- IPR007858: Dpy-30 motif (conserved_site) [6-46]
Interaction partners: - Set1 complex component swd1
- Set1 complex component swd3
- Set1 complex component ash2
- Histone-lysine N-methyltransferase, H3 lysine-4 specific
- Set1 complex component spp1
- Set1 complex component swd2
- Set1 complex component shg1
- Lid2 complex component snt2
- Lid2 complex component lid2
- Lid2 complex component jmj3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006325 (chromatin organization), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0006338 (chromatin remodeling), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0000118 (histone deacetylase complex), GO:0070822 (Sin3-type complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome)