Protein: Voltage-gated delayed rectifier potassium channel KCNH4 (A8WHX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier. Activates at more negative voltages, exhibits fast prepulse- independent activation kinetics and deactivates much more slowly, but shows no inactivation
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MPVMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVQSLYPIVYCSDGFCELTGYARAELMQKSCACHFLYGPETSDRLMAQIQGALDERREFKTELVFYKKGGTQFWCLLDIVPIKNEKGEVVLFLVSHKDITDNKKDQDEEQSPERDEETGLEVHKVTRPPGFNANRRRSRAVLYQLSGHLQKQDKSKLKINNNMFGEKPPIPEYKVAAIQKSRFILLHYGTFKAGWDWLILLATFYVAVTVPYNVCFTVVGGRDEASTPRSPPSVSDILVEILFMLDIVLNFRTTFVSTSGQVVYDARSICVHYVTTWLFVDLIAALPFDLLYAFNVSVYFGVHLLKTVRLLRLLRLLQKLERYSQYSAVVLTLLMSMFALLAHWMACVWYIIGRSEIENNSPGSWDIGWLHELGKRLGTPYFLSPLASLIPDSLRPTILDGLVVNSSQWNGSDLVAHEPVWNSSQLNSTGTAPAAPSNAGQTGAVLGGGPSIRSSYVTSLYFALSSLTSVGFGNVSANTDSEKIFSICTMLIGALMHAAVFGNVTAIIQRMYSRRSLYHTRTKDLKDFIRVHRLPKALAQRMLECFQTTWSVNNGIDVSELLKDFPDELRADIAMHLNKELLQLPLFESASRGCLRSLSLIIKTSFCAPGEFLIRQGDALQAIYFVCSGSMEVLKDNTVLAILGKGDLIGSDSLTKEQVIKTNANVKALTYCDLQYISLKGLREVLRLYPEYAQKFVSEIQHDLTYNLREGSGADLDWESNGGLVKKLPAIREDEENDEEQNSVSRAPRSPLRLTRALSSPLRSPLLPPRPFRAPSESMRPATLQIPVVSFSSAPPELSPRFVDGIETESNSSSTQRFEFGPSLPQSGPPSPSPVSQEQLESKQSITKLSEEMTSLSQQVSQLSKELQEMTRLLRPILVM
InterPro domains: - IPR035965: PAS domain superfamily (homologous_superfamily) [41-135]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [548-732]
- IPR003938: Potassium channel, voltage-dependent, EAG/ELK/ERG-like (family) [221-708]
- IPR050818: Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type (family) [23-908]
- IPR003950: Potassium channel, voltage-dependent, ELK (family) [101-655]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [585-750]
- IPR005821: Ion transport domain (domain) [229-549]
- IPR000014: PAS domain (domain) [40-140]
- IPR000595: Cyclic nucleotide-binding domain (domain) [620-737]
- IPR001610: PAC motif (repeat) [94-136]
- IPR000700: PAS-associated, C-terminal (domain) [93-145]
Interaction partners: - Potassium voltage-gated channel subfamily KQT member 2 isoform X2
- K2P10.1 potassium channel subunit
- A-type voltage-gated potassium channel KCND1
- Potassium voltage-gated channel subfamily C member 3b
- Voltage-dependent L-type calcium channel subunit beta-2
- Scn4ba protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0042802 (identical protein binding), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022832 (voltage-gated channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098739 (import across plasma membrane), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0099587 (inorganic ion import across plasma membrane), GO:0006811 (monoatomic ion transport), GO:0098659 (inorganic cation import across plasma membrane), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:1990573 (potassium ion import across plasma membrane), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)