Protein: Laminin subunit beta-1 (O44565)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
Sequence: MLRPPFWLGLLLSLLLVFIEAQHPLQQNEDRCQDRSCYPITGNLLIGRKSQLKATSTCGSQGRQRFCIVSHLEEQTKCFYCDSRTEWKPQREPYRLSHRIENVVTEVMDDKNRNWYQSENGAQNVSISFDLEAEFHFTHLIMTFKSFRPAAMIIERSADFGKTWQVYRYFAYDCDSSFPGIPEGPPKKHTDVICTSQYSDVAPSTGGEIVYKVISPHIVTENPYADEISTLLKITNLRFNFTKLHTLGDDLLDYRPEIDEKYYYAIYEIVVRGSCSCYGHASRCIPIDPHVSPNTVMERADIVHGRCECMHNTEGLNCEKCKAFYNDLPWRPAIGDEKNECRQCNCNRHALRCHFDRAVYESSGFVSGGVCDDCMHNTQGKNCEQCKPFFYRDPRRTIDDPHVCLPCECDKAGSQNKGICEGEEDAERGLVAGKCYCKTNVDGNRCDRCKNGYWNLTETNVDGCVACTCNLLGTYNNEGCDKYTGMCTCKRLVTGENCDQCLPEHYGLSEHVDGCKACDCDIGGSYDNTCEITTGQCKCREGFSGRRCETADSSFYCADITHYVYEAEYANLTRGEVKTREWPSQPHEQTFTGEGFAQAVEGTIITVNPIVEVSQKYNVIIRHDGARDPVGWENIQITVVRPEAEGDGSCSDAPPSDDFLIARIYPGSRYIEVQPAICLEAGVQYELRIQFNEKRGNSHPQERAAANILIDSILLAPPTSELHIFQGSARAEQHLTEYNRYQCRHLALSLSLFKDQRNEVCERYVCPIAAALLNKTSECNCDATGSVSGICNVQGGQCECKPNVVGRRCDQCAIGTYGFGPSGCKKCDCDAVGSLGNDCDKQSGQCVCREKGIYGRQCNQCQPGFWGFPECRTCQCNDHANICDQSSGACIECRDLTTGHYCDRCQDGYYGDPRLGVGIPCKPCPCPGGPTSGYQHADTCYLRNSGNNTQDIVCNCKSGYQGERCGECAQNHWGSPREVGGTCERCDCNGNIDMAMEGSCDAATGECLKCLHHTEGAQCEHCVDGYYGDAKLKTCQRCVCNELGTNSTKGACDRVSGQCPCHDNIIGMQCDQCAENHFNLASGAGCEACGCDSNGVVLNHEGVPHLQCNIFDGQCQCKPGRGGRKCDQCEDLYWGDPTTPDGCHRCECNPTGSKSLQCHRNNGTCECQAGSGGALCNECARGYTGQWPYCNPCGECFHQWDNIMQKLQKQVHALIDTANNIEDTGVASAYDADFEKMEETLKETKKALSDANISKEDIEEMSKKLALLKKQVIAGREKLGAIETRISNITQAVDFAQKDLEHLQKEVDKVTKATIELEDKASKIKEADVLGAFNITRESASKSLDAQRRTDAAIGKLAAAENQALRASELLEKNKNDFEKQYVENEEALNEAETLLGGLESVLPKLNEQVCGASSAPCDALCGGPGSCGFCGGQSCMEGAVSKANQAKSFATEADTRLDEKQKEAEEVLSIVRDVLTETTKAKAKAEKAYEVAKNTAQRANSSRAELDKIAEEIGEFLTAQKSSPEQIRNLAEEVLGKEISLTPDQITDLTGKIKESLAKINNIDEILNETRGNKSIAANLESRAVKANKEAELLQKAMEEIREALQLADQAYNNVTSVLEEIDTMQVQARELIDKARNSTEAVEGKAQAANTTLAELEGVMSGVKVEYLQISESAKNALTTVDAALAAATNAEQKNKQIQTDLERATELLEKRMEGNVAPQQRAEKLRERAAKLLYQAQRHNDDIDNLSKDSTEMRLDDYETILADLNSRLERVTRDIHEKTDFHATCG
InterPro domains: - IPR000742: EGF-like domain (domain) [340-1191]
- IPR013015: Laminin IV type B (domain) [557-773]
- IPR050440: Laminin/Netrin Extracellular Matrix (family) [30-455]
- IPR002049: Laminin-type EGF domain (domain) [274-1196]
- IPR008211: Laminin, N-terminal (domain) [31-274]
- IPR056863: Laminin/attractin/netrin-like, EGF domain (domain) [344-916]
Interaction partners: - Laminin-like protein lam-2
- Integrin beta pat-3
- Dystroglycan 1
- Laminin-like protein epi-1
- Laminin subunit alpha lam-3
- Netrin receptor unc-5
- Netrin receptor unc-40
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005201 (extracellular matrix structural constituent)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0008037 (cell recognition), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0040012 (regulation of locomotion), GO:0009266 (response to temperature stimulus), GO:0050790 (regulation of catalytic activity), GO:0008038 (neuron recognition), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0060255 (regulation of macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009408 (response to heat), GO:0042127 (regulation of cell population proliferation), GO:0035966 (response to topologically incorrect protein), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0002164 (larval development), GO:0080090 (regulation of primary metabolic process), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0030030 (cell projection organization), GO:0051788 (response to misfolded protein), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0045229 (external encapsulating structure organization), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0007414 (axonal defasciculation), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0043062 (extracellular structure organization), GO:0051247 (positive regulation of protein metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0030182 (neuron differentiation), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0120036 (plasma membrane bounded cell projection organization), GO:0030198 (extracellular matrix organization), GO:0045862 (positive regulation of proteolysis), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0051345 (positive regulation of hydrolase activity), GO:0071711 (basement membrane organization), GO:0010952 (positive regulation of peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:0061564 (axon development), GO:0010950 (positive regulation of endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix), GO:0005604 (basement membrane)