Protein: Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2) (G3UW82)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cytoplasm, myofibril {ECO:0000269|PubMed:28752107}. Note=Thick filaments of the myofibrils.
Sequence: MSSDAEMAVFGEAAPYLRKSEKERIEAQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVKTEAGATLTVKEDQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDDLAKSEAKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDERLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSKFRKIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE
InterPro domains: - IPR000048: IQ motif, EF-hand binding site (binding_site) [787-835]
- IPR014751: DNA repair protein XRCC4-like, C-terminal (homologous_superfamily) [1552-1779]
- IPR004009: Myosin, SH3 domain (domain) [33-82]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [60-844]
- IPR001609: Myosin head, motor domain-like (domain) [80-786]
- IPR002928: Myosin tail (domain) [853-1930]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [84-715]
- IPR008989: Myosin S1 fragment, N-terminal (homologous_superfamily) [33-80]
Interaction partners: - Myosin-1
- Myosin light chain 1/3, skeletal muscle isoform
- Titin
- Myosin-4
- Myosin light chain 3
- Troponin T, fast skeletal muscle
- Troponin C, skeletal muscle
- Actin, alpha skeletal muscle
- Troponin I, fast skeletal muscle
- Myosin, light chain 12A, regulatory, non-sarcomeric
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0014823 (response to activity), GO:0030048 (actin filament-based movement), GO:0016043 (cellular component organization), GO:0009611 (response to wounding), GO:0070252 (actin-mediated cell contraction), GO:0042060 (wound healing), GO:0010256 (endomembrane system organization), GO:0061024 (membrane organization), GO:0001778 (plasma membrane repair), GO:0007009 (plasma membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0099080 (supramolecular complex), GO:0070938 (contractile ring), GO:0032153 (cell division site), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031672 (A band), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0005794 (Golgi apparatus), GO:0005826 (actomyosin contractile ring), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0005911 (cell-cell junction), GO:0030864 (cortical actin cytoskeleton), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)