Protein: tRNA (32-2'-O)-methyltransferase regulator trm732 (O60081)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: May be involved in the methylation of the 2'-O-ribose of nucleotides at position 32 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)) by SPAC4F10.03c.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
Sequence: MDLSVIKAASLDLESLPSQPTVSSFQQLRETFIQSKSEDWYLKNGLFFRYYSFLKSSLENATLDGPSQVACLDTISVWLRRIFNACKQDPEISKYVWDTMELKFWTNLFSLPANKISIPGLTGVQVAVKDVFSKSLQLYLLVCPSEDIKNDFLLDSLKHALHWDRHAKVVCTAIQLLVKVTGAEAVFAFQPDFFEQSLKLLKDYSYAQAISSTILTVLTLRFKSLSEETEDREEVETKWMNIWCPIILYEFYGNDRQVQAGMSSFLIPSLLGVSPGITVKFLSRLQNYPNVSKDARDAACLYALKIAKDSKIIKNLDLVKEHAFVKTLFKHPDIKIQLACFRLIALCPNVSSPLSFEDFDCLESNIEFSFNVLDPDSRQILLKSMQDFFIRLRASCHSIARTMRSRHSDKVALSGLLDRAMQFLTSFISVCKKHLYPTCNYQQVLVSLSFLDTLISFGLDDNVESSSIREAQHDFPFSMVIIDRDLSRLMIDRLKDPYDDIRNLCLKILLSYKSLPGFISDSDAYFLFNHGLELLNAVRSHECDGGAKTIYLCNHFMEKSVPGSVLANTKVILNRLKSNIEHAKTSLLEAAVNCPLQGYLIQLTYIFQSLSPTIVKNDNESWKNIVMELIKASETIWGLIKDVLCDDSPEGNLPDGEGEGGIVSNLEDTPAQLILSYSWRSLKETSSLLTVLLTKCLSLFDEEFTPFTLNYYGELMMTWLWEIRHRGAFTSVYPCFIEYCSFLFECNKHEISELPDPWLHKNLSVIQEKSSFITRRSGGIPLSITAILVAGKDKREQLIEQTVISLISIAKQPVEQKNIAGQFDLPQVHAMNTLKTIFTEHRLSSVSVEYLEPAIALSIEGFSHELWPIRNCSVMLFTALINRAFGSKKPKDAVNLGNNKGLSTKMFFSKFPTLHDYLLRELEVSVASLSSNDQPSTGLYPILNMFSRLQYAQPYGNENEWTGLSQFEPLIFKCTASRICKVREIASLSLTCLLDCSKMTTFIVSQLKGVAGLQQNEIHGKLLTIRAVLSCFFSKLTLQQVQEFYEVVPLAFINCFLEFTSSKTSFYAKKLFLEVLNSYFMSNTDSNAKRLQQLRRMTMDYCKRMLLDRKANVTNVFNTIGLPIHQQMAATIFLENLKEFSVYCDAHSIGFLVSKLLHYEFYEVQLTTLRSIVDSPRKKIIVNNPEILQALIKLTPRNQWSQVRALALSLLSDSLNSTSYRLLGISCSDMVSNILSNECLPIKESFIVLLGSCIKQLKTENFLEYKVTFAKWVEILLSYSNEYQPFSSRKAALDSIIHFDLFNAESTAEAFSFEFYILYLLLGDFLNDDDEEIRSLAANHAYQVLGTSAQCVTEIWNLWKLRTKATFGGQHDFQHCINKRLILEDGCELASVQLDNALSRNCSLFERERQNLYYSDNQKLEDLLFYASYPNEKLKDWATDGINAILSRFEDVSRDGPLGKTSDPNVWFTIYKIIRIAEHVHLPLDRVHSLMNRIDGHPSFCQ
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [134-1339]
- IPR019442: THADA/TRM732, DUF2428 (domain) [625-867]
- IPR056842: tRNA (32-2'-O)-methyltransferase regulator THADA-like, C-terminal TPR repeats region (domain) [870-1027]
- IPR051954: tRNA (32-2'-O)-methyltransferase regulator THADA (family) [27-1499]
- IPR056843: tRNA (32-2'-O)-methyltransferase regulator THADA-like, TPR repeats region (domain) [239-503]
Interaction partners: - tRNA
- tRNA
- tRNA
- tRNA
- tRNA
- tRNA
- tRNA
- tRNA N
- rRNA methyltransferase 2, mitochondrial
- Putative tRNA pseudouridine synthase C16C4.06c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0001510 (RNA methylation), GO:0010467 (gene expression), GO:0030488 (tRNA methylation), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0034470 (ncRNA processing), GO:0006400 (tRNA modification), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)