wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial (EC 1.1.1.223) (EC 1.1.1.243) (Q5C9I9)
Organism: Mentha piperita (Peppermint) (Mentha aquatica x Mentha spicata)
Function: Involved in the biosynthesis of menthol and related monoterpenes in leaves. Can use (-)-trans-carveol and, with a lower relative velocity, (-)-trans-isopiperitenol, (+)-neomenthol, (+)-neoisomenthol and (-)-cis-isopiperitenol as substrates, but not (-)-cis-carvenol, (-)-menthol, (+)-isomenthol, 7-hydroxy-limonene, (-)-isopiperitenone or (-)-carvone.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:15542490}.
Sequence: MASVKKLAGKVAIVTGGASGIGEVTARLFAERGARAVVIADMQPEKGGTVAESIGGRRCSYVHCDITDEQQVRSVVDWTAATYGGVDVMFCNAGTASATAQTVLDLDLAQFDRVMRVNARGTAACVKQAARKMVELGRGGAIICTASATVHHAGPNLTDYIMSKCGVLGLVRSASLQLGVHGIRVNSVSPTALATPLTATIGLRTAADVESFYGQVTSLKGVAITAEHVAEAVAFLASDEAAFVTGHDLAVDGGLQCLPFVAVAK
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [9-255]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [11-255]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044085 (cellular component biogenesis), GO:0009698 (phenylpropanoid metabolic process), GO:0022607 (cellular component assembly), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043933 (protein-containing complex organization), GO:0009806 (lignan metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009699 (phenylpropanoid biosynthetic process), GO:0065003 (protein-containing complex assembly), GO:0009807 (lignan biosynthetic process), GO:0051259 (protein complex oligomerization), GO:0051260 (protein homooligomerization), GO:0051262 (protein tetramerization), GO:0051289 (protein homotetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Zn(2)-C6 fungal-type domain-containing protein (A0A1D8PHG0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MAAKKGRKQVVRCLSCKKLRIKCDQVRPKCEYCAHTNRECIYPSDIPTSETNAEKDSPVEDIRRDLPLTQLTSVLSVSQLELRALKFFNDIGKLIVSYKNQRYIDNWEAVINPLSFQSPIVKKTLLATSSMLLSHFMNINTVDSKVLTSSFSVDSSQEAQAFFQTGTKYLQESIDERKHLLQDNSGFGIERIIVNDLITFGCLLIYNHKLVPLISATGYDVISMAKAYSDTRKMYSQSMTGLRLESLFFPKSNPILTCPPETNYWFTRVLEFEIVAFVSRNGNKSANMEEYFQALMDTFLLLKDACYAMAIVRFPFPLIACLTNFSDKYRQLLRNGDEFAFRLLFIYSCLCVISRIPLNRNDNIFVDYISEFKNIIFSKYGEFSYPIDRELYHLVIRTNFVVDFGDMTRFHPLQQCEPLMDLSWLERYIDSLEKTNTLLQCI
InterPro domains: - IPR036864: Zn(2)-C6 fungal-type DNA-binding domain superfamily (homologous_superfamily) [4-94]
- IPR053157: Sterol Uptake Control Transcription Regulator (family) [1-354]
- IPR001138: Zn(2)Cys(6) fungal-type DNA-binding domain (domain) [7-51]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0030447 (filamentous growth), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Lin-28 homolog protein (Protein lin-28 homolog B) (S0BDM9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
Sequence: MAEGGPRRGGGSDTARTPPQSLSGSGYCKWFNVRMGFGFISMTSSEGKPVDPPLDVFVHQSKLVMEGFRSLREGEQVEFTFKRSSKGLESLRVTGPGGGPCSGSERRPKAKAPPLKRKPKGDRCYNCGGLDHHAKECGLPPQPKKCHYCQSVTHMVAQCPHKGAPSPSASQDPQRPSTSAQSPEEESRSGSSSSPEEASQRGSRSQRWRKSRD
InterPro domains: - IPR011129: Cold-shock domain (domain) [25-96]
- IPR051373: Lin-28 homolog RNA-binding protein (family) [17-207]
- IPR054081: Lin-28A-like, second zinc knuckle (domain) [143-169]
- IPR036875: Zinc finger, CCHC-type superfamily (homologous_superfamily) [115-162]
- IPR001878: Zinc finger, CCHC-type (domain) [123-161]
- IPR002059: Cold-shock protein Csp, DNA-binding (domain) [23-95]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [18-103]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0009790 (embryo development), GO:0031099 (regeneration), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Seminal fluid protein 23F (B4ZJ89)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MRLYKIFCLICSIFGCVSALKDPSCAVELFGQGACNTLITRIGYLRWENMCTSKNFVACDTDGTSFESIKECEDKCKE
InterPro domains: - IPR036880: Pancreatic trypsin inhibitor Kunitz domain superfamily (homologous_superfamily) [22-78]
Interaction partners: - GEO13347p1
- MIP11594p
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0061134 (peptidase regulator activity), GO:0004857 (enzyme inhibitor activity), GO:0061135 (endopeptidase regulator activity), GO:0030414 (peptidase inhibitor activity), GO:0004866 (endopeptidase inhibitor activity), GO:0004867 (serine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0019953 (sexual reproduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: RNA-editing ligase 2, mitochondrial (RNA ligase 2) (EC 6.5.1.3) (TbMP48) (P86924)
Organism: Trypanosoma brucei brucei
Function: RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:11134327}.
Sequence: MLRRLGVRHFRRTPLLFVGGDGSIFERYTEIDNSNERRINALKGCGMFEDEWIATEKVHGANFGIYSIEGEKMIRYAKRSGIMPPNEHFFGYHILIPELQRYVTSIREMLCEKQKKKLHVVLINGELFGGKYDHPSVPKTRKTVMVAGKPRTISAVQTDSFPQYSPDLHFYAFDIKYKETEGGDYTTLVYDEAIELFQRVPGLLYARAVIRGPMSKVAAFDVERFVTTIPPLVGMGNYPLTGNWAEGLVVKHSRLGMAGFDPKGPTVLKFKCTAFQEISTDRAQGPRVDEMRNVRRDSINRAGVQLPDLESIVQDPIQLEASKLLLNHVCENRLKNVLSKIGTEPFEKEEMTPDQLATLLAKDALKDFLKDTEPSIVNIPVLIRKDLTRYVIFESRRLVCSQWKDILKRQSPDFSE
InterPro domains: - IPR041948: RNA ligase 1/2, C-terminal domain superfamily (homologous_superfamily) [318-408]
- IPR021122: RNA ligase domain, REL/Rln2 (domain) [50-253]
- IPR012647: RNA ligase, Rnl2 (family) [25-408]
- IPR040609: RNA ligase 2, C-terminal (domain) [320-389]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016886 (ligase activity, forming phosphoric ester bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0016070 (RNA metabolic process), GO:0009451 (RNA modification), GO:0016071 (mRNA metabolic process), GO:0016556 (mRNA modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:1902494 (catalytic complex), GO:0020023 (kinetoplast), GO:0005737 (cytoplasm), GO:0005739 (mitochondrion), GO:0031019 (mitochondrial mRNA editing complex), GO:0043229 (intracellular organelle), GO:0045293 (mRNA editing complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Interleukin-4 (D1YSM1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MRTFLLLVLTLVPVSESKLKIDEILLMEIIQSVNGILNGKGEKMDLDQFIPDIYETGHYSKKTLCQAGMALKGKIPSRSHLQRQLNAYAAYTGTGNCSVSTSGECTMKEFLEKTKACCHYLYSAQRT
InterPro domains: - IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [20-127]
Interaction partners: - Interleukin 13 receptor alpha 1
- Interleukin 13 receptor, alpha 2.
- Interleukin 2 receptor gamma common.b
- Interleukin 2 receptor gamma common.a
- Interleukin 13
- Interferon gamma 1.
- Interleukin family protein
- CD4-1 molecule
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Phosphodiesterase delta-like protein (Q18268)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MATTATRHQDSKLSEKAESILAGFKLNWMNLRDAETGKVLWQSTEDMADPKREHKAHVPKNLLKCRTVSREINFTSSVKIEKFRLEQRVYLKGTIIEEWYFDFGFVIPDSTNTWQNMIEAAPESQMFPPSVLSGNVVVETLFYDGDLLVSTSRVRLYYD
InterPro domains: - IPR014756: Immunoglobulin E-set (homologous_superfamily) [14-158]
- IPR037036: GMP phosphodiesterase, delta subunit superfamily (homologous_superfamily) [12-158]
- IPR017287: Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit (family) [1-159]
- IPR008015: GMP phosphodiesterase, delta subunit (domain) [19-158]
Interaction partners: - ADP-ribosylation factor-like protein 3
- ADP-ribosylation factor-like protein 2
- guanylate kinase
- adenylate cyclase
- GMP reductase
- Probable GMP synthase
- Adenine phosphoribosyltransferase
- Putative cytosolic 5'-nucleotidase 3
- Inosine triphosphate pyrophosphatase
- 5'-nucleotidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009791 (post-embryonic development), GO:0002164 (larval development), GO:0002119 (nematode larval development), GO:0040024 (dauer larval development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0030424 (axon), GO:0097708 (intracellular vesicle)
Protein: Nuclear autoantigenic sperm protein (Q5T626)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MAMESTATAAVAAELVSADKIEDVPAPSTSADKVESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNIDETEGSEEDDKENDKTEEMPNDSVLENKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYVQAVEEFQSCLNLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFSKSIEVIENRMAVLNEQVKEAEGSSAEYKKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPGGGGSSVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVPSGNEVSENMEEEAENQAESRAAVEGTVEAGATVESTAC
InterPro domains: - IPR019544: Tetratricopeptide, SHNi-TPR domain (domain) [206-239]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [26-323]
- IPR051730: Nuclear autoantigenic sperm protein-like (family) [22-409]
- IPR019734: Tetratricopeptide repeat (repeat) [43-278]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0042393 (histone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0006334 (nucleosome assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0006338 (chromatin remodeling), GO:0065004 (protein-DNA complex assembly), GO:0034728 (nucleosome organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: 40S ribosomal protein S14 (Q4FKG9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MSKKQEVKYYGSSAGKDQLVYGVVHIYASFNDTFVHVTDMSGRETFCKVTGGMKVKADRDESSPYAAMMAAQDVVARCKECGINALHVKMRATGGVGTKSPGPGAQAALRALARAGMKIGRIEDVTPVPTDSTRRKGSRRGRRL
InterPro domains: - IPR018102: Small ribosomal subunit protein uS11, conserved site (conserved_site) [109-131]
- IPR036967: Small ribosomal subunit protein uS11 superfamily (homologous_superfamily) [1-144]
- IPR001971: Small ribosomal subunit protein uS11 (family) [1-141]
Interaction partners: - Protein translation factor SUI1 homolog, putative
- 60S ribosomal protein L19, putative
- 40S ribosomal protein S18, putative
- Polyubiquitin, putative
- 60S ribosomal protein L39, putative
- Large ribosomal subunit protein eL18
- 60S ribosomal protein L5, putative
- 40S ribosomal protein S26
- Small ribosomal subunit protein uS5
- 40S ribosomal protein S16, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Profilin-1A (Acidic profilin IA) (Profilin IA) (P68696)
Organism: Acanthamoeba castellanii (Amoeba)
Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular location: Cytoplasm, cytoskeleton.
Sequence: MSWQTYVDTNLVGTGAVTQAAILGLDGNTWATSAGFAVTPAQGQTLASAFNNADPIRASGFDLAGVHYVTLRADDRSIYGKKGSAGVITVKTSKSILVGVYNEKIQPGTAANVVEKLADYLIGQGF
InterPro domains: - IPR036140: Profilin superfamily (homologous_superfamily) [2-126]
- IPR048278: Profilin (family) [1-126]
- IPR027310: Profilin conserved site (conserved_site) [1-8]
- IPR005455: Profilin, eukaryotic type (family) [1-126]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0043621 (protein self-association)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048609 (multicellular organismal reproductive process), GO:0032989 (cellular component morphogenesis), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0001675 (acrosome assembly), GO:0030154 (cell differentiation), GO:0048515 (spermatid differentiation), GO:0016043 (cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0007283 (spermatogenesis), GO:0010256 (endomembrane system organization), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0033363 (secretory granule organization), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0007009 (plasma membrane organization), GO:0016050 (vesicle organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: NCK adaptor protein 1 (C9JVV5)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDSASPADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIK
InterPro domains: - IPR039801: Epidermal growth factor receptor kinase substrate 8-like (family) [6-94]
- IPR035562: Nck1, SH3 domain 1 (domain) [3-61]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [4-61]
- IPR001452: SH3 domain (domain) [2-61]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)