Protein: Reticulophagy regulator 1 (Reticulophagy receptor 1) (Q8VE91)
Organism: Mus musculus (Mouse)
Function: Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Active under basal conditions (By similarity). Required for collagen quality control in a LIR motif-dependent manner. Required for long-term survival of nociceptive and autonomic ganglion neurons.
Subcellular location: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19838196}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H6L5}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MASPAPEEHATQGCPATEEQPPRPGVPGEEAGPEGAGPQVEEAAGRVAAALTWLLGEPVLWLGWRADELLSWKRPLRSLLTFLGANLLFWFLALTPWRVYHLISVMILGRVIMQIIKEMVLSRTRGAQLWRSLTESWEVINSKPDERARLSQCIAESWMNFSMFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLFAFLCPLFKCNDIGQKIYSKVKSILLKLDFGIGEYINQKKRERSEADKEKSHKDDSELDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGTGTNDEDELSLGLPTELKRKKQQLDSAHRPSKERQSAAGLSLPLKSDQALHLMSNLAGDVITAAMTAAIKDQLEGARQALTQVAPTAGEDTDTEEGDDFELLDQAELDQIESELGLTQDQGAEAQQSKKSSGFLSNLLGGH
InterPro domains: - IPR055255: Reticulophagy regulator 1, N-terminal reticulon-homology domain (domain) [50-242]
- IPR043384: Reticulophagy receptor 1/3 (family) [1-480]
- IPR057282: RETREG1-3/ARL6IP-like, N-terminal reticulon-homology domain (domain) [66-239]
Interaction partners: - Gamma-aminobutyric acid receptor-associated protein
- 60S ribosomal export protein NMD3
- Microtubule-associated protein 1 light chain 3 beta
- Large subunit GTPase 1 homolog
- Translocation protein SEC62
- Proliferation-associated protein 2G4
- Eukaryotic translation initiation factor 6
- Cell cycle progression protein 1
- Large ribosomal subunit protein eL24
- Large ribosomal subunit protein uL23
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0043495 (protein-membrane adaptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0032963 (collagen metabolic process), GO:0009056 (catabolic process), GO:0016043 (cellular component organization), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0030574 (collagen catabolic process), GO:0016236 (macroautophagy), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0022411 (cellular component disassembly), GO:0007029 (endoplasmic reticulum organization), GO:0061912 (selective autophagy), GO:1903008 (organelle disassembly), GO:0061709 (reticulophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)