Protein: Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Endogenous vascular elastase) (Properdin factor D) (P32038)
Organism: Rattus norvegicus (Rat)
Function: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Subcellular location: Secreted.
Sequence: MHSSVYLVALVVLEAAVCVAQPRGRILGGQEAMAHARPYMASVQVNGTHVCGGTLVDEQWVLSAAHCMDGVTKDEVVQVLLGAHSLSSPEPYKHLYDVQSVVLHPGSRPDSVEDDLMLFKLSHNASLGPHVRPLPLQREDREVKPGTLCDVAGWGVVTHAGRRPDVLQQLTVSIMDRNTCNLRTYHDGAITKNMMCAESNRRDTCRGDSGGPLVCGDAVEAVVTWGSRVCGNRRKPGVFTRVATYVPWIENVLSGNVSVNVTA
InterPro domains: - IPR001314: Peptidase S1A, chymotrypsin family (family) [52-214]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [34-250]
- IPR018114: Serine proteases, trypsin family, histidine active site (active_site) [62-67]
- IPR033116: Serine proteases, trypsin family, serine active site (active_site) [203-214]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [15-256]
- IPR001254: Serine proteases, trypsin domain (domain) [25-254]
Interaction partners: - Complement factor B
- 30 kDa adipocyte complement-related protein
- Complement C3
- Complement C2
- Resistin
- Properdin factor, complement
- Complement C4
- Complement C4A.
- Leptin
- Fatty acid-binding protein, adipocyte
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0002684 (positive regulation of immune system process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0009991 (response to extracellular stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0007584 (response to nutrient), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0050778 (positive regulation of immune response), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0006956 (complement activation), GO:0032496 (response to lipopolysaccharide), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0002237 (response to molecule of bacterial origin), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)