Protein: UDP-N-acetyl-D-mannosaminuronic acid transferase (UDP-ManNAcA transferase) (EC 2.4.1.180) (P27836)
Organism: Escherichia coli (strain K12)
Function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
Sequence: MNNNTTAPTYTLRGLQLIGWRDMQHALDYLFADGQLKQGTLVAINAEKMLTIEDNAEVRELINAAEFKYADGISVVRSVRKKYPQAQVSRVAGADLWEELMARAGKEGTPVFLVGGKPEVLAQTEAKLRNQWNVNIVGSQDGYFKPEQRQALFERIHASGAQIVTVAMGSPKQEIIMRDCRLVHPDALYMGVGGTYDVFTGHVKRAPKIWQTLGLEWLYRLLSQPSRIKRQLRLLRYLRWHYTGNL
InterPro domains: - IPR023085: UDP-N-acetyl-D-mannosaminuronic acid transferase (family) [1-246]
- IPR004629: Glycosyl transferase WecG/TagA/CpsF (family) [8-243]
Interaction partners: - UDP-N-acetylglucosamine 2-epimerase
- TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase
- Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- UDP-N-acetyl-D-mannosamine dehydrogenase
- dTDP-4-amino-4,6-dideoxygalactose transaminase
- Glucose-1-phosphate thymidylyltransferase 2
- dTDP-fucosamine acetyltransferase
- Lipid III flippase
- Probable ECA polymerase
- ECA polysaccharide chain length modulation protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0015562 (efflux transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0009311 (oligosaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0008653 (lipopolysaccharide metabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0009103 (lipopolysaccharide biosynthetic process), GO:0009312 (oligosaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0046401 (lipopolysaccharide core region metabolic process), GO:0009244 (lipopolysaccharide core region biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)