Protein: Voltage-gated potassium channel regulatory subunit KCNG1 (Potassium voltage-gated channel subfamily G member 1) (Voltage-gated potassium channel subunit Kv6.1) (kH2) (Q9UIX4)
Organism: Homo sapiens (Human)
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q14721}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000250|UniProtKB:Q14721}.
Sequence: MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDILFGSASSDTRDNN
InterPro domains: - IPR028325: Voltage-gated potassium channel (family) [63-476]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [203-359]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [65-164]
- IPR003969: Potassium channel, voltage dependent, Kv6 (family) [99-478]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [41-177]
- IPR000210: BTB/POZ domain (domain) [63-172]
- IPR003968: Potassium channel, voltage dependent, Kv (family) [114-459]
- IPR005821: Ion transport domain (domain) [227-467]
Interaction partners: - Ubiquitin-like protein FUBI
- Heterogeneous nuclear ribonucleoprotein K
- Fragile X messenger ribonucleoprotein 1
- RNA-binding protein FXR2
- Poly
- RNA-binding protein FXR1
- Poly
- Voltage-gated potassium channel subunit beta-3
- Small ribosomal subunit protein uS13
- Vitamin K-dependent gamma-carboxylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022832 (voltage-gated channel activity), GO:0005251 (delayed rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0071805 (potassium ion transmembrane transport), GO:0030001 (metal ion transport), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)