Protein: Large ribosomal subunit protein uL22m (54S ribosomal protein L22, mitochondrial) (P53881)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:14576278}. Note=Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1. {ECO:0000269|PubMed:25609543}.
Sequence: MNFHTARISQVGVISRALLSSVSRRWIHVTPISLNNSGGSLFGSITENKPKEGKNRGDEDAGSFSNRLAIASDSSGEAPEVNRDSITIENDKLLQQHIISLQQPEQLASQSLLSPLKREIYEANCKINGGFYKKDTIVKLPNSSERYKLKLTKREIEVLEPSVYAQSYRIKSSMKKATLLLRLLGGLDVMKAISQCHFSNKKIAREVAELLQKGVKDGQKLGLKPEDLYISQIWTGSDGFWRKRVEFKARTRIGIISHPYIHVRCILRTKSVTKRRLAYEAHLKEQKRAPWVQLGDKPIRGVTGGVYKW
InterPro domains: - IPR001063: Large ribosomal subunit protein uL22 (family) [165-268]
- IPR047867: Large ribosomal subunit protein uL22, bacterial/organelle-type (family) [115-304]
- IPR036394: Ribosomal protein uL22 superfamily (homologous_superfamily) [133-299]
Interaction partners: - Large ribosomal subunit protein bL27m
- Large ribosomal subunit protein uL4m
- Large ribosomal subunit protein bL19m
- Large ribosomal subunit protein uL29m
- Large ribosomal subunit protein bL17m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL3m
- Large ribosomal subunit protein bL32m
- Small ribosomal subunit protein bS16m
- Small ribosomal subunit protein uS15m
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0140053 (mitochondrial gene expression), GO:0043043 (peptide biosynthetic process), GO:0032543 (mitochondrial translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0044391 (ribosomal subunit), GO:0000313 (organellar ribosome), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0005762 (mitochondrial large ribosomal subunit), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005761 (mitochondrial ribosome), GO:0000315 (organellar large ribosomal subunit), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0015934 (large ribosomal subunit), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005840 (ribosome)