Protein: CARD domain-containing protein E10 (Q66677)
Organism: Equine herpesvirus 2 (strain 86/87) (EHV-2)
Function: Activates host NF-kappa-B and JNK pathways. Induces hyperphosphorylation and redistribution of host bcl-10 from the cytoplasm to the plasma membrane. The inhibitory effect of cellular bcl-10 on NF-kappa-B pathway is then overcome allowing NF-kappa-B activation.
Subcellular location: Host cell membrane {ECO:0000269|PubMed:11238466}. Note=E10 does not contain a putative transmembrane and must therefore be targeted to the plasma membrane in a different manner. The two cysteines located on the C-terminal region are essential for the protein localization and constitute a consensus site for geranylgeranylation.
Sequence: MAEKYPLQAGDPCVTLTEEDIWDVERLCLEELRVLLVSHLKSHKHLDHLRAKKILSREDAEEVSSRATSRSRAGLLVDMCQDHPRGFQCLKESCKNEVGQEHLVDLLERAFEKHCGDKLTQKWWESGADGRNPRRPPGSEDNSGYTALLPTNPSGGGPSIGSGHSRPRGRDDSGGIGGGVYPFSHGGARVVGGGWGGWGESGGAGRGGSLLSGGHGGHPPHGGPGGGGRDYYGGGGSGYYESIPEPANFPNSGGGGRGGGVRYDAGGDGRLGGLPPDPQEVDDPSLSVQGRGGPAPDPPSPPLRTRRFFCC
InterPro domains: - IPR033238: B-cell lymphoma/leukemia 10/E10 (family) [14-111]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [9-122]
- IPR001315: CARD domain (domain) [21-110]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0019209 (kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0019222 (regulation of metabolic process), GO:0035821 (modulation of process of another organism), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0050790 (regulation of catalytic activity), GO:0010942 (positive regulation of cell death), GO:0044093 (positive regulation of molecular function), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031341 (regulation of cell killing), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0051709 (regulation of killing of cells of another organism), GO:0080090 (regulation of primary metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0038061 (NIK/NF-kappaB signaling), GO:0051247 (positive regulation of protein metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0051174 (regulation of phosphorus metabolic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0019220 (regulation of phosphate metabolic process), GO:0043549 (regulation of kinase activity), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0045860 (positive regulation of protein kinase activity), GO:0032147 (activation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)