Protein: Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a) (Q61098)
Organism: Mus musculus (Mouse)
Function: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3.
Subcellular location: Membrane {ECO:0000250|UniProtKB:Q13478}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MHHEELILTLCILIVKSASKSCIHRSQIHVVEGEPFYLKPCGISAPVHRNETATMRWFKGSASHEYRELNNRSSPRVTFHDHTLEFWPVEMEDEGTYISQVGNDRRNWTLNVTKRNKHSCFSDKLVTSRDVEVNKSLHITCKNPNYEELIQDTWLYKNCKEISKTPRILKDAEFGDEGYYSCVFSVHHNGTRYNITKTVNITVIEGRSKVTPAILGPKCEKVGVELGKDVELNCSASLNKDDLFYWSIRKEDSSDPNVQEDRKETTTWISEGKLHASKILRFQKITENYLNVLYNCTVANEEAIDTKSFVLVRKEIPDIPGHVFTGGVTVLVLASVAAVCIVILCVIYKVDLVLFYRRIAERDETLTDGKTYDAFVSYLKECHPENKEEYTFAVETLPRVLEKQFGYKLCIFERDVVPGGAVVEEIHSLIEKSRRLIIVLSQSYLTNGARRELESGLHEALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLKWRADSPSMNSRFWKNLVYLMPAKAVKPWREESEARSVLSAP
InterPro domains: - IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [362-518]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [25-237]
- IPR015621: Interleukin-1 receptor family (family) [19-525]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [370-529]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [18-316]
- IPR007110: Immunoglobulin-like domain (domain) [212-312]
- IPR003599: Immunoglobulin domain subtype (domain) [25-315]
- IPR041416: IL-1Ra-like, immunoglobulin domain (domain) [24-120]
Interaction partners: - Interleukin-18 receptor accessory protein
- Interleukin-18
- Interleukin-33
- Interleukin-1 receptor accessory protein
- Interleukin-12 receptor subunit beta-2
- Interleukin-18-binding protein
- Interleukin-7 receptor subunit alpha
- Single Ig IL-1-related receptor
- Interleukin-36 receptor antagonist protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019955 (cytokine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0001817 (regulation of cytokine production), GO:0010033 (response to organic substance), GO:0050776 (regulation of immune response), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0070887 (cellular response to chemical stimulus), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0034097 (response to cytokine), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0002703 (regulation of leukocyte mediated immunity), GO:0071310 (cellular response to organic substance), GO:0002718 (regulation of cytokine production involved in immune response), GO:0032649 (regulation of type II interferon production), GO:0010628 (positive regulation of gene expression), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0032729 (positive regulation of type II interferon production), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:0002821 (positive regulation of adaptive immune response), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0019221 (cytokine-mediated signaling pathway), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0002819 (regulation of adaptive immune response), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0002724 (regulation of T cell cytokine production), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0071345 (cellular response to cytokine stimulus), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0002726 (positive regulation of T cell cytokine production), GO:0002825 (regulation of T-helper 1 type immune response), GO:0002827 (positive regulation of T-helper 1 type immune response), GO:0002711 (positive regulation of T cell mediated immunity), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0002709 (regulation of T cell mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)