Protein: Histone deacetylase (EC 3.5.1.98) (A0A2R8QIW0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|PIRNR:PIRNR037913}.
Sequence: MALSSQGTKKKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNKQQTDIAINWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPIMSKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTIKGHAKCVEYMKSFNLPLLMLGGGGYTIRNVARCWTFETAVALDSTIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNDYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAVQEDSGDEEDDPDKRISIRAHDKRIACDEEFSDSEDEGQGGRRNAANYKKPKRVKTEEEKDGEEKKGEPTDVKEEEKASEEKMDTKGPKEELKTV
InterPro domains: - IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [8-381]
- IPR000286: Histone deacetylase HDAC (family) [138-265]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [10-374]
- IPR003084: Class I/II Histone deacetylase HDAC (family) [1-475]
- IPR023801: Histone deacetylase domain (domain) [29-318]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0003714 (transcription corepressor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048066 (developmental pigmentation), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021548 (pons development), GO:0060255 (regulation of macromolecule metabolic process), GO:0060041 (retina development in camera-type eye), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0042246 (tissue regeneration), GO:0051962 (positive regulation of nervous system development), GO:0016477 (cell migration), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048645 (animal organ formation), GO:0198738 (cell-cell signaling by wnt), GO:0060042 (retina morphogenesis in camera-type eye), GO:0008285 (negative regulation of cell population proliferation), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0030902 (hindbrain development), GO:0009799 (specification of symmetry), GO:0048857 (neural nucleus development), GO:0022037 (metencephalon development), GO:0031324 (negative regulation of cellular metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060322 (head development), GO:0050673 (epithelial cell proliferation), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0050931 (pigment cell differentiation), GO:0080090 (regulation of primary metabolic process), GO:0031099 (regeneration), GO:0055123 (digestive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0016055 (Wnt signaling pathway), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0030318 (melanocyte differentiation), GO:0010001 (glial cell differentiation), GO:0050769 (positive regulation of neurogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0035272 (exocrine system development), GO:0003401 (axis elongation), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0031101 (fin regeneration), GO:0007420 (brain development), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0001501 (skeletal system development), GO:0072359 (circulatory system development), GO:0007417 (central nervous system development), GO:0009953 (dorsal/ventral pattern formation), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0021532 (neural tube patterning), GO:0002244 (hematopoietic progenitor cell differentiation), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0007507 (heart development), GO:0030097 (hemopoiesis), GO:0021915 (neural tube development), GO:0060284 (regulation of cell development), GO:0007423 (sensory organ development), GO:0010720 (positive regulation of cell development), GO:0051960 (regulation of nervous system development), GO:0061008 (hepaticobiliary system development), GO:0009855 (determination of bilateral symmetry), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0060914 (heart formation), GO:0010092 (specification of animal organ identity), GO:0007422 (peripheral nervous system development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0060429 (epithelium development), GO:0051253 (negative regulation of RNA metabolic process), GO:0048565 (digestive tract development), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0031016 (pancreas development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0048262 (determination of dorsal/ventral asymmetry), GO:0048592 (eye morphogenesis), GO:0048263 (determination of dorsal identity), GO:0048709 (oligodendrocyte differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0150063 (visual system development), GO:0001889 (liver development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0021903 (rostrocaudal neural tube patterning), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0060028 (convergent extension involved in axis elongation), GO:0043009 (chordate embryonic development), GO:0001654 (eye development), GO:0048934 (peripheral nervous system neuron differentiation), GO:0060218 (hematopoietic stem cell differentiation), GO:0048935 (peripheral nervous system neuron development), GO:0006355 (regulation of DNA-templated transcription), GO:0048706 (embryonic skeletal system development), GO:0031017 (exocrine pancreas development), GO:0060026 (convergent extension), GO:0042063 (gliogenesis), GO:0003128 (heart field specification), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0003139 (secondary heart field specification), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0070603 (SWI/SNF superfamily-type complex), GO:0000118 (histone deacetylase complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:1904949 (ATPase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097346 (INO80-type complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031011 (Ino80 complex), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome)