Protein: Cathepsin E (EC 3.4.23.34) (P16228)
Organism: Rattus norvegicus (Rat)
Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity).
Subcellular location: Endosome {ECO:0000269|PubMed:8491674, ECO:0000269|PubMed:9572291}. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Sequence: MKPLFVLLLLLLLLDLAQAQGVLHRVPLRRHQSLRKKLRAQGQLSDFWRSHNLDMIEFSESCNVDKGINEPLINYLDMEYFGTVSIGSPSQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQSSTYMEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVEGQQFGESVKEPGQTFVNAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQGYWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPKKIKQLQEAIGATPMDGEYAVDCATLNMMPNVTFLINGVSYTLSPTAYILPDLVDGMQFCGSGFQGLDIQPPAGPLWILGDVFIRKFYSVFDRGNNQVGLAPAVP
InterPro domains: - IPR033121: Peptidase family A1 domain (domain) [79-396]
- IPR001461: Aspartic peptidase A1 (family) [17-394]
- IPR021109: Aspartic peptidase domain superfamily (homologous_superfamily) [8-396]
- IPR001969: Aspartic peptidase, active site (active_site) [95-291]
- IPR012848: Aspartic peptidase, N-terminal (domain) [25-51]
Interaction partners: - Cathepsin S
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0033218 (amide binding), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0042277 (peptide binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:0019538 (protein metabolic process), GO:0050886 (endocrine process), GO:0006952 (defense response), GO:0008217 (regulation of blood pressure), GO:1901700 (response to oxygen-containing compound), GO:0043170 (macromolecule metabolic process), GO:0003013 (circulatory system process), GO:0010033 (response to organic substance), GO:0035902 (response to immobilization stress), GO:0098542 (defense response to other organism), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032496 (response to lipopolysaccharide), GO:0010243 (response to organonitrogen compound), GO:0008015 (blood circulation), GO:0003073 (regulation of systemic arterial blood pressure), GO:0033993 (response to lipid), GO:0042742 (defense response to bacterium), GO:0002237 (response to molecule of bacterial origin), GO:0051604 (protein maturation), GO:0014070 (response to organic cyclic compound), GO:0001990 (regulation of systemic arterial blood pressure by hormone), GO:0010467 (gene expression), GO:0002526 (acute inflammatory response), GO:0003094 (glomerular filtration), GO:0016485 (protein processing), GO:0001991 (regulation of systemic arterial blood pressure by circulatory renin-angiotensin), GO:0140448 (signaling receptor ligand precursor processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)