Protein: Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) (O35276)
Organism: Rattus norvegicus (Rat)
Function: High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
Subcellular location: Membrane {ECO:0000250|UniProtKB:O60462}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60462}.
Sequence: MDMFPLTWIFLALYFSGHKVRSQQDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWVVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSVLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPRMEIILQFLTFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSKLRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPPENFQCNAPLGMESGRIANEQISASSTFSDGRWTPQQSRLHGDDNGWTPNVDSNKEYLQVDLRFLTMLTAIATQGAISRETQKGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATELVLNKLHTPLLTRFIRIRPQTWHLGIALRLELFGCRVTDAPCSNMLGMLSGLIADTQISASSTREYLWSPSAARLVSSRSGWFPRNPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAMEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFEPVPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPMDEDATECGENCSFEDDKDLQLPSGFNCNFDFPEETCGWMYDRAKWLQSTWISSANPNDRTFPDDKNFLKLQSDGGREGQFGRLISPPVHLPRSPVCMEFQYQAMGGHGVALQVVREARQESKLLWVIREDQGSEWKHGRIILPSYDMEYQIVFEGVIGKGRSGEISIDDIRISTDVPLENCMEPISAFAVDIPEIHGGEGYEDEIDDDYEGDWNNSSSTSGAGSPSSGKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKINHQKCCSEA
InterPro domains: - IPR050633: Neuropilin/Multicopper Oxidase/Coagulation Factor (family) [21-924]
- IPR000998: MAM domain (domain) [641-802]
- IPR014648: Neuropilin (family) [1-925]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [642-794]
- IPR000421: Coagulation factor 5/8, C-terminal domain (domain) [276-592]
- IPR000859: CUB domain (domain) [28-267]
- IPR022579: Neuropilin, C-terminal (domain) [847-925]
- IPR035914: Spermadhesin, CUB domain superfamily (homologous_superfamily) [24-266]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [275-596]
Interaction partners: - Semaphorin 3F
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor C
- Plexin-A1
- Plexin-A3
- Semaphorin-3C
- Vascular endothelial growth factor receptor 3
- Semaphorin-3A
- Semaphorin-3B
- Vascular endothelial growth factor receptor 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0017154 (semaphorin receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:2000026 (regulation of multicellular organismal development), GO:0051129 (negative regulation of cellular component organization), GO:0009611 (response to wounding), GO:0050922 (negative regulation of chemotaxis), GO:0050920 (regulation of chemotaxis), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0032101 (regulation of response to external stimulus), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0032102 (negative regulation of response to external stimulus), GO:0048843 (negative regulation of axon extension involved in axon guidance), GO:0061387 (regulation of extent of cell growth), GO:0032535 (regulation of cellular component size), GO:0050770 (regulation of axonogenesis), GO:0050768 (negative regulation of neurogenesis), GO:0031344 (regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0030516 (regulation of axon extension), GO:0030517 (negative regulation of axon extension), GO:0051960 (regulation of nervous system development), GO:0031345 (negative regulation of cell projection organization), GO:0010721 (negative regulation of cell development), GO:0050771 (negative regulation of axonogenesis), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0008361 (regulation of cell size), GO:0048841 (regulation of axon extension involved in axon guidance), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030427 (site of polarized growth), GO:0150034 (distal axon), GO:0009986 (cell surface), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0030426 (growth cone), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)