Protein: Protein SST2 (P11972)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Desensitization to alpha-factor pheromone. Is involved in regulating the signaling pathway for responding to mating pheromone.
Sequence: MVDKNRTLHELSSKNFSRTPNGLIFTNDLKTVYSIFLICLDLKEKKHSSDTKSFLLTAFTKHFHFTFTYQEAIKAMGQLELKVDMNTTCINVSYNIKPSLARHLLTLFMSSKLLHTPQDRTRGEPKEKVLFQPTPKGVAVLQKYVRDIGLKTMPDILLSSFNSMKLFTFERSSVTDSIIHSDYLIHILFIKMMGAKPNVWSPTNADDPLPCLSSLLEYTNNDDTFTFEKSKPEQGWQAQIGNIDINDLERVSPLAHRFFTNPDSESHTQYYVSNAGIRLFENKTFGTSKKIVIKYTFTTKAIWQWIMDCTDIMHVKEAVSLAALFLKTGLIVPVLLQPSRTDKKKFQISRSSFFTLSKRGWDLVSWTGCKSNNIRAPNGSTIDLDFTLRGHMTVRDEKKTLDDSEGFSQDMLISSSNLNKLDYVLTDPGMRYLFRRHLEKELCVENLDVFIEIKRFLKKMTILKKLIDSKHCDKKSNTSTSKNNIVKTIDSALMKQANECLEMAYHIYSSYIMIGSPYQLNIHHNLRQNISDIMLHPHSPLSEHFPTNLYDPSPASAESAASSISSTEADTLGEPPEVSLKPSKNLSNENCSFKKQGFKHQLKEYKPAPLTLAETHSPNASVENSHTIVRYGMDNTQNDTKSVESFPATLKVLRKLYPLFEIVSNEMYRLMNNDSFQKFTQSDVYKDASALIEIQEKC
InterPro domains: - IPR044926: RGS, subdomain 2 (homologous_superfamily) [394-689]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [257-366]
- IPR016137: RGS domain (domain) [420-689]
- IPR000591: DEP domain (domain) [50-358]
- IPR036305: RGS domain superfamily (homologous_superfamily) [416-687]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [268-361]
Interaction partners: - Guanine nucleotide-binding protein alpha-1 subunit
- Guanine nucleotide-binding protein subunit beta
- Pheromone alpha factor receptor
- Guanine nucleotide-binding protein alpha-2 subunit
- Cyclin-dependent kinase inhibitor FAR1
- Mitogen-activated protein kinase FUS3
- Nuclear fusion protein FUS1
- Regulator of G-protein signaling 2
- Barrierpepsin
- Pheromone a factor receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0042221 (response to chemical), GO:0031139 (positive regulation of conjugation with cellular fusion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0031137 (regulation of conjugation with cellular fusion), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032005 (signal transduction involved in positive regulation of conjugation with cellular fusion), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009966 (regulation of signal transduction), GO:0010033 (response to organic substance), GO:0019236 (response to pheromone), GO:0071310 (cellular response to organic substance), GO:0000749 (response to pheromone triggering conjugation with cellular fusion), GO:0023058 (adaptation of signaling pathway), GO:0000750 (pheromone-dependent signal transduction involved in conjugation with cellular fusion), GO:0071444 (cellular response to pheromone)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005667 (transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)