Protein: Toll-like receptor 3 (Q99MB1)
Organism: Mus musculus (Mouse)
Function: Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome
Sequence: MKGCSSYLMYSFGGLLSLWILLVSSTNQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSSCKDSAPFELLFIISTSMLLVFILVVLLIHIEGWRISFYWNVSVHRILGFKEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKSHCILNWPVQKERINAFHHKLQVALGSRNSAH
InterPro domains: - IPR000483: Cysteine-rich flanking region, C-terminal (domain) [646-698]
- IPR001611: Leucine-rich repeat (repeat) [53-633]
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [751-902]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [755-901]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [50-633]
- IPR041015: Toll-like receptor 3 trans-membrane domain (domain) [699-731]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [28-698]
Interaction partners: - TNF receptor-associated factor 6
- TIR domain-containing adapter molecule 1
- Protein unc-93 homolog B1
- TIR domain-containing adapter molecule 2
- Receptor-interacting serine/threonine-protein kinase 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
- Myeloid differentiation primary response protein MyD88
- Mitogen-activated protein kinase kinase kinase 7
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Glycogen synthase kinase-3 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0001816 (cytokine production), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0001817 (regulation of cytokine production), GO:1904018 (positive regulation of vasculature development), GO:0002697 (regulation of immune effector process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0001819 (positive regulation of cytokine production), GO:0009615 (response to virus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0044093 (positive regulation of molecular function), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0006952 (defense response), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0009891 (positive regulation of biosynthetic process), GO:0098542 (defense response to other organism), GO:2000026 (regulation of multicellular organismal development), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0033554 (cellular response to stress), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0098586 (cellular response to virus), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0032642 (regulation of chemokine production), GO:0002703 (regulation of leukocyte mediated immunity), GO:0000165 (MAPK cascade), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0032655 (regulation of interleukin-12 production), GO:0032675 (regulation of interleukin-6 production), GO:0032735 (positive regulation of interleukin-12 production), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production), GO:0031098 (stress-activated protein kinase signaling cascade), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0032722 (positive regulation of chemokine production), GO:0051607 (defense response to virus), GO:0002718 (regulation of cytokine production involved in immune response), GO:1901342 (regulation of vasculature development), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0045766 (positive regulation of angiogenesis), GO:0032755 (positive regulation of interleukin-6 production), GO:0010628 (positive regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0140546 (defense response to symbiont), GO:0032481 (positive regulation of type I interferon production), GO:0031326 (regulation of cellular biosynthetic process), GO:0043331 (response to dsRNA), GO:0007249 (I-kappaB kinase/NF-kappaB signaling), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0045765 (regulation of angiogenesis), GO:0014070 (response to organic cyclic compound), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0061081 (positive regulation of myeloid leukocyte cytokine production involved in immune response), GO:0051403 (stress-activated MAPK cascade), GO:2001141 (regulation of RNA biosynthetic process), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0043410 (positive regulation of MAPK cascade), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0032760 (positive regulation of tumor necrosis factor production), GO:0043408 (regulation of MAPK cascade), GO:0010935 (regulation of macrophage cytokine production), GO:0032648 (regulation of interferon-beta production), GO:0006355 (regulation of DNA-templated transcription), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0032680 (regulation of tumor necrosis factor production), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0032728 (positive regulation of interferon-beta production), GO:0043330 (response to exogenous dsRNA), GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade), GO:0060907 (positive regulation of macrophage cytokine production), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0032874 (positive regulation of stress-activated MAPK cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0007254 (JNK cascade), GO:0046328 (regulation of JNK cascade), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0046330 (positive regulation of JNK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0005783 (endoplasmic reticulum), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0036019 (endolysosome), GO:0000323 (lytic vacuole), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0045335 (phagocytic vesicle), GO:0097708 (intracellular vesicle), GO:0032009 (early phagosome)