Protein: Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) (P22008)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01925}.
Sequence: MSTPRIAFIGAGNMAASLIGGLRAQGVPAAQIRASDPGAEQRAKIAGEFAIDVVESNAEAVADADVVVLSVKPQAMKAVCQALAPALKPEQLIVSIAAGIPCASLEAWLGQPRPVVRCMPNTPALLRQGASGLYANAQVSAAQCEQAGQLLSAVGIALWLDDEAQIDAVTAVSGSGPAYFFLLMQAMTDAGEKLGLSRETASRLTLQTALGAAQMALSSEVEPAELRRRVTSPNGTTEAAIKSFQANGFEALVEQALNAASQRSAELAEQLGQ
InterPro domains: - IPR008927: 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily (homologous_superfamily) [162-270]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [5-160]
- IPR028939: Pyrroline-5-carboxylate reductase, catalytic, N-terminal (domain) [5-99]
- IPR029036: Pyrroline-5-carboxylate reductase, dimerisation domain (domain) [163-267]
- IPR053790: Pyrroline-5-carboxylate reductase-like conserved site (conserved_site) [223-245]
- IPR000304: Pyrroline-5-carboxylate reductase-like (family) [3-270]
Interaction partners: - Bifunctional protein PutA
- Ornithine cyclodeaminase
- 4-hydroxyproline 2-epimerase
- Proline iminopeptidase
- Uncharacterized protein PA0392
- Pyridoxal phosphate homeostasis protein
- Glutamate 5-kinase
- Gamma-glutamyl phosphate reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0006560 (proline metabolic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0006561 (proline biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)