Protein: Nitrogen metabolite repression protein nmrA (Negative-acting nitrogen regulatory protein nmrA) (Nitrogen metabolite regulation protein) (Q5AU62)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: May be a redox sensor protein. Has much higher affinity for NAD(P) than for NAD(P)H. Has similar affinity for NAD and NADP. Negative transcriptional regulator involved in the post-transcriptional modulation of the GATA-type transcription factor areA, forming part of a system controlling nitrogen metabolite repression (By similarity). Interferes with the interaction between areA and target DNA. Overexpression leads to areA inhibition.
Subcellular location: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:17854403}.
Sequence: MAQQKKTIAVVNATGRQAASLIRVAAAVGHHVRAQVHSLKGLIAEELQAIPNVTLFQGPLLNNVPLMDTLFEGAHLAFINTTSQAGDEIAIGKDLADAAKRAGTIQHYIYSSMPDHSLYGPWPAVPMWAPKFTVENYVRQLGLPSTFVYAGIYNNNFTSLPYPLFQMELMPDGTFEWHAPFDPDIPLPWLDAEHDVGPALLQIFKDGPQKWNGHRIALTFETLSPVQVCAAFSRALNRRVTYVQVPKVEIKVNIPVGYREQLEAIEVVFGEHKAPYFPLPEFSRPAAGSPKGLGPANGKGAGAGMMQGPGGVISQRVTDEARKLWSGWRDMEEYAREVFPIEEEANGLDWML
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [3-352]
- IPR051164: NmrA-like oxidoreductase (family) [4-251]
- IPR008030: NmrA-like domain (domain) [4-335]
Interaction partners: - Nitrogen regulatory protein areA
- Nitrite reductase [NAD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016645 (oxidoreductase activity, acting on the CH-NH group of donors), GO:0016646 (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0006766 (vitamin metabolic process), GO:0010033 (response to organic substance), GO:0034599 (cellular response to oxidative stress), GO:1901334 (lactone metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009110 (vitamin biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0033993 (response to lipid), GO:0018130 (heterocycle biosynthetic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0042181 (ketone biosynthetic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0046165 (alcohol biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0042364 (water-soluble vitamin biosynthetic process), GO:1901336 (lactone biosynthetic process), GO:0046395 (carboxylic acid catabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0046189 (phenol-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)