wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: CCDC81 HU domain-containing protein (Q383J9)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MEPSKTSTRRNPDQCYACYSEIANIVAQMGGLYCHQSRNAGPQLLCRIWRTLCESVEETLVRKRSCIIPDFLHASIKVQRVSPFDGEINLYKPQMVLLPDFLSKFHVQNVLTFRDAHYHATVPNIISFDEIAAIVGTDRHIVKAAVSESVREIGKYLDRNKCAVLSIDVGVAFLEFRGREYRIKWADTFLERLKREVGPRSFVEPYIPPTMAPDARGCRFQSECLTKESLHGSLNDTLQRESRTQVVEMCGSQNKQFTLSPS
InterPro domains: - IPR040673: CCDC81, HU domain 2 (domain) [126-194]
- IPR028034: CCDC81, HU domain 1 (domain) [23-109]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0033554 (cellular response to stress), GO:0034605 (cellular response to heat)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)
Protein: non-specific serine/threonine protein kinase (EC 2.7.11.1) (Aurora/IPL1-related kinase 1) (Serine/threonine-protein kinase aurora-A) (Q6DBZ4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}.
Sequence: MDSGARSKSSRDLKIHRPENEKVSAAGPKRVPVTQSVQKPVSNPHTRVLGAAQGPQRVQRPVGKTSCPGDQNTRPEQHKPAAHSKPQPKPPLSAETNKTAEPSKQDKPHQTPSSTTSTSSNTSGSSKSSKKAWTLENFDIGRALGKGKFGSVYLAREQQTKFILALKVLFKKQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDAARVYLILEFAPKGELYGELQRCGTFDDQRSATYIMELADALRYCHSKAVIHRDIKPENLLLGANGELKIADFGWSVHTPSSRRSTLCGTLDYLPPEMIEGKTHDEKVDLWSLGVLCYEFLVGRPPFETKSHEETYRKISRVEFTYPAHVSNGSRDLINRLLKHNPMHRLPIQGVMEHPWVVENSTKKPTTYTATANN
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [114-395]
- IPR030611: Aurora kinase A (domain) [132-389]
- IPR030616: Aurora kinase-like (family) [16-399]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [257-269]
- IPR017441: Protein kinase, ATP binding site (binding_site) [144-167]
- IPR000719: Protein kinase domain (domain) [138-388]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004712 (protein serine/threonine/tyrosine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002040 (sprouting angiogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0000922 (spindle pole), GO:0031616 (spindle pole centrosome), GO:0005813 (centrosome), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0015630 (microtubule cytoskeleton)
Protein: Cytochrome c biogenesis protein family (F4K0A8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Plastid, chloroplast {ECO:0000256|ARBA:ARBA00004229}.
Sequence: MNLSVNRCITGGFVGGFSSCRLNHGKKRWVRAGKHCELERERSLVSDAVSLERLESKSIKLAMLASGLGVANLVTLSSAKAADLKMIVLDQATSIYILAEGSLGDSVGNFLYSANQQANEAVQDQLSALSVTSLAVIFGAGLVTSLSPCTLSVLPLTLGYIGAFGSGKSRGQVIGDTVAFALGLATTLALLGIVASFAGKAYGQIGQGLPVAASGLAIVMGLNLLEIIELQLPSFFNNFDPRAAAANFPSSVQAYLAGLTFALAASPCSTPVLATLLGYVATSRDPVIGGSLLLTYTTGYVAPLIVAASFAGALQSLLSLRKVSAWINPISGALLLGGGLYTFLDRLFPAATMVM
InterPro domains: - IPR003834: Cytochrome C biogenesis protein, transmembrane domain (domain) [132-330]
- IPR051790: Cytochrome c-type biogenesis DsbD-related (family) [107-355]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0017004 (cytochrome complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0042651 (thylakoid membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009579 (thylakoid), GO:0055035 (plastid thylakoid membrane)
Protein: Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109) (O77751)
Organism: Oryctolagus cuniculus (Rabbit)
Function: May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (By similarity). Can form voltage-gated calcium and potassium channels in vitro.
Subcellular location: Nucleus outer membrane {ECO:0000269|PubMed:9720923}; Multi-pass membrane protein {ECO:0000305|PubMed:21381722}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21381722, ECO:0000269|PubMed:9720923}; Multi-pass membrane protein {ECO:0000305|PubMed:21381722}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21381722, ECO:0000269|PubMed:9720923}; Multi-pass membrane protein {ECO:0000269|PubMed:21381722}.
Sequence: MAGSGSSAPWGKHLLHAVLMVLVALVLLHSALAQSHRDFAPPGQQRREAPVDLLTQIGRSVRETLDTWIGPETMHLISETLSQVMWAISSAISVAFFALSGIAAQLLTALGLDGDHLTQGLKLSPSQVQTFLLWGAGALVVYWLLSLLLGLVLAVLGRILGGLKLVIFLAGFVALVRSVPDPSTRALLLLALLTLYALLSRLTGSRASGAQLEAKVRGLERQVDELRWRQRRAAKGARSVEEE
InterPro domains: - IPR039492: Transmembrane protein 109 (family) [1-242]
Interaction partners: - Glutamyl-tRNA
- Lengsin
- Glutamine synthetase
- GMP synthase
- Fatty acid desaturase 6
- Amidophosphoribosyltransferase
- glutamine--fructose-6-phosphate transaminase
- glutamine--fructose-6-phosphate transaminase
- Isoamyl acetate-hydrolyzing esterase 1 homolog
- trans-L-3-hydroxyproline dehydratase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0008219 (cell death), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0012501 (programmed cell death), GO:0035556 (intracellular signal transduction), GO:0033554 (cellular response to stress), GO:0097190 (apoptotic signaling pathway), GO:0097193 (intrinsic apoptotic signaling pathway), GO:0072331 (signal transduction by p53 class mediator), GO:0006974 (cellular response to DNA damage stimulus), GO:0006915 (apoptotic process), GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage), GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator), GO:0042771 (intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0035869 (ciliary transition zone), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)
Protein: Carboxysome shell protein CcmK2 (Carbon dioxide-concentrating mechanism protein CcmK2) (P72761)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: One of the shell proteins of the carboxysome, a polyhedral inclusion where RuBisCO (ribulose bisphosphate carboxylase, rbcL-rbcS) is sequestered. The central pore probably regulates metabolite flux. Hexamers make sheets that form the facets of the polyhedral carboxysome (Probable).
Subcellular location: Carboxysome {ECO:0000255|HAMAP-Rule:MF_00854, ECO:0000305|PubMed:16081736, ECO:0000305|PubMed:17993516, ECO:0000305|PubMed:19177356, ECO:0000305|PubMed:19844993}. Note=This cyanobacterium makes beta-type carboxysomes. {ECO:0000305|PubMed:17993516}.
Sequence: MSIAVGMIETRGFPAVVEAADSMVKAARVTLVGYEKIGSGRVTVIVRGDVSEVQASVSAGIEAANRVNGGEVLSTHIIARPHENLEYVLPIRYTEEVEQFRTY
InterPro domains: - IPR046380: Carboxysome shell protein CcmK (family) [1-102]
- IPR020808: Bacterial microcompartments protein, conserved site (conserved_site) [21-40]
- IPR050575: Bacterial microcompartment shell (family) [2-97]
- IPR000249: Bacterial microcompartment domain (domain) [3-81]
- IPR044872: CcmK/CsoS1, bacterial microcompartment domain (domain) [4-90]
- IPR037233: CcmK-like superfamily (homologous_superfamily) [1-103]
Interaction partners: - Carboxysome shell vertex protein CcmL
- Carboxysome assembly protein CcmM
- Carboxysome assembly protein CcmN
- Ribulose bisphosphate carboxylase large chain
- Ribulose bisphosphate carboxylase small subunit
- Carboxysome shell protein CcmK1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031469 (bacterial microcompartment), GO:0031470 (carboxysome)
Protein: Transmembrane BAX inhibitor motif containing 4 (G3XAA5)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MADPDPRYPRSSIEDDFNYGSSVASATVHIRMVLQRDCTFSKQYMRIPSAPSATLNIIRFFHLRQSGRSGMVNIFYKGPTFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGLFALLWILCLSGFLKFFFYSEIMELVLAAAGALLFCGFIIYDTHSLMHKLSPEEYVLAAISLYLDIINLFLHLLRFLEAVNKK
InterPro domains: - IPR006214: Bax inhibitor 1-related (family) [72-280]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:1902531 (regulation of intracellular signal transduction), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0050848 (regulation of calcium-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: (2E,6E)-farnesyl diphosphate synthase (Dimethylallyltranstransferase) (Farnesyl diphosphate synthase) (Geranyltranstransferase) (A0A087X1D8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDS
InterPro domains: - IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [66-174]
- IPR000092: Polyprenyl synthetase-like (family) [110-174]
- IPR039702: Farnesyl pyrophosphate synthase-like (family) [77-174]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0016125 (sterol metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:1902652 (secondary alcohol metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0008202 (steroid metabolic process), GO:0016126 (sterol biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process), GO:0008203 (cholesterol metabolic process), GO:0006694 (steroid biosynthetic process), GO:0006695 (cholesterol biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Palustrin-2AJ1 (G3ETQ3)
Organism: Amolops jingdongensis (Chinese torrent frog)
Function: Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Has low hemolytic activity, low cytotoxicity and low antioxidant activity.
Subcellular location: Secreted {ECO:0000269|PubMed:21816202}.
Sequence: MFTLKKPLLVLLFLGTVSLSLCEQERAADDDEGEVIEEEVKRGFMDTAKNVAKNVAVTLIDKLRCKVTGGC
InterPro domains: - IPR004275: Frog antimicrobial peptide, propeptide (domain) [2-40]
- IPR012521: Frog antimicrobial peptide, brevinin-2/esculentin type (domain) [43-71]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0009620 (response to fungus), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0050832 (defense response to fungus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium), GO:0050830 (defense response to Gram-positive bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: E3 ubiquitin-protein ligase ATL4 (EC 2.3.2.27) (Protein ARABIDOPSIS TOXICOS EN LEVADURA 4) (Protein ATL4) (RING-H2 finger X1a) (RING-H2 zinc finger protein ATL4) (RING-H2 zinc finger protein RHX1a) (RING-type E3 ubiquitin transferase ATL4) (Q9LY41)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: E3 ubiquitin-protein ligase able to catalyze polyubiquitination with ubiquitin-conjugating enzyme E2 UBC8 in vitro.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MESLINPSHGGGNYDSHSSSLDSLKPSVLVIILILLMTLLISVSICFLLRCLNRCSHRSVLPLSSSSSVATVTSDSRRFSGHRVSPETERSSVLDSLPIFKFSSVTRRSSSMNSGDCAVCLSKFEPEDQLRLLPLCCHAFHADCIDIWLVSNQTCPLCRSPLFASESDLMKSLAVVGSNNGGGENSFRLEIGSISRRRQTPIPESVEQHRTYSIGSFDYIVDDVDSEISESNFNRGKQEDATTTTATATAVTTNPTSFEASLAADIGNDGSRSWLKDYVDRLSRGISSRAMSFRSSGRFFTGSSRRSEELTVMDLEANHAGEEISELFRWLSGV
InterPro domains: - IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [75-163]
- IPR001841: Zinc finger, RING-type (domain) [116-159]
Interaction partners: - Probable LRR receptor-like serine/threonine-protein kinase At1g29720
- Transcription factor LHW
- Squamosa promoter-binding-like protein 1
- ATP sulfurylase 1, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Possible dioxygenase (O53311)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRDVDGQLHALSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFNRRECRLPQFAVATWNGLVWINLDADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLGLHRQTLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFPNSALAIAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAMALVGDHPGAS
InterPro domains: - IPR001663: Aromatic-ring-hydroxylating dioxygenase, alpha subunit (family) [7-374]
- IPR017941: Rieske [2Fe-2S] iron-sulphur domain (domain) [52-161]
- IPR015879: Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain (domain) [188-372]
- IPR036922: Rieske [2Fe-2S] iron-sulphur domain superfamily (homologous_superfamily) [20-175]
Interaction partners: - Possible transcriptional regulatory protein
- Dioxygenase
- Probable oxidoreductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0009072 (aromatic amino acid metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:1901606 (alpha-amino acid catabolic process), GO:0006570 (tyrosine metabolic process), GO:0009074 (aromatic amino acid family catabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0006572 (tyrosine catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)