Protein: Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide] (Q9GZV9)
Organism: Homo sapiens (Human)
Function: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Subcellular location: Secreted {ECO:0000269|PubMed:16638743}. Note=Secretion is dependent on O-glycosylation.
Sequence: MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI
InterPro domains: - IPR008996: Cytokine IL1/FGF (homologous_superfamily) [40-167]
- IPR002209: Fibroblast growth factor family (family) [36-177]
Interaction partners: - Klotho
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 4
- Polypeptide N-acetylgalactosaminyltransferase 3
- Fibroblast growth factor receptor 2
- Phosphate-regulating neutral endopeptidase PHEX
- Fibroblast growth factor receptor 3
- Beta-klotho
- Parathyroid hormone
- Sodium-dependent phosphate transport protein 2C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0070851 (growth factor receptor binding), GO:0005104 (fibroblast growth factor receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0009967 (positive regulation of signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0098771 (inorganic ion homeostasis), GO:0009891 (positive regulation of biosynthetic process), GO:0055082 (intracellular chemical homeostasis), GO:0010035 (response to inorganic substance), GO:2000026 (regulation of multicellular organismal development), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0030278 (regulation of ossification), GO:1902074 (response to salt), GO:0030500 (regulation of bone mineralization), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0000165 (MAPK cascade), GO:0071774 (response to fibroblast growth factor), GO:0030643 (intracellular phosphate ion homeostasis), GO:0010468 (regulation of gene expression), GO:0055074 (calcium ion homeostasis), GO:0070167 (regulation of biomineral tissue development), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0055080 (monoatomic cation homeostasis), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0055062 (phosphate ion homeostasis), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0071363 (cellular response to growth factor stimulus), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0070371 (ERK1 and ERK2 cascade), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0044344 (cellular response to fibroblast growth factor stimulus), GO:0008543 (fibroblast growth factor receptor signaling pathway), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)