Protein: NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (Q0PIT9)
Organism: Sus scrofa (Pig)
Function: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).
Subcellular location: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03159}. Secreted {ECO:0000255|HAMAP-Rule:MF_03159}. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255|HAMAP-Rule:MF_03159}.
Sequence: MSGLRALLGLGLPVAGSRLPRVRVQAGACRARPTWWGPQRLISGGRGDVEGMASSAVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKVYPPTSLSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYHPTIYYPKRPNKPLFTALVTQCQKMDIPFLDEMPSEPTLIDELYELVVDAIFGFSFKGEVREPFRSILSVLNGLTVPIASIDIPSGWDVERGNSGGIQPDLLISLTAPKKSAAQFTGRYHYLGGRFVPPALEKKYQLNLPPYPDTECVYRLQ
InterPro domains: - IPR004443: YjeF N-terminal domain (domain) [60-276]
- IPR036652: YjeF N-terminal domain superfamily (homologous_superfamily) [56-288]
- IPR032976: YjeF N-terminal domain-containing protein NAXE-like (family) [51-287]
Interaction partners: - Pyridoxine-5'-phosphate oxidase
- ATP-dependent
- Intercellular adhesion molecule 5
- m7GpppN-mRNA hydrolase
- Probable ATP-dependent RNA helicase DDX6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0051093 (negative regulation of developmental process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044238 (primary metabolic process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0035239 (tube morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0001568 (blood vessel development), GO:0046483 (heterocycle metabolic process), GO:1905952 (regulation of lipid localization), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0048731 (system development), GO:0019637 (organophosphate metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0051668 (localization within membrane), GO:1901343 (negative regulation of vasculature development), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:1901342 (regulation of vasculature development), GO:0061024 (membrane organization), GO:0006796 (phosphate-containing compound metabolic process), GO:0045765 (regulation of angiogenesis), GO:0032368 (regulation of lipid transport), GO:0002040 (sprouting angiogenesis), GO:0072524 (pyridine-containing compound metabolic process), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0016525 (negative regulation of angiogenesis), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0032371 (regulation of sterol transport), GO:0031579 (membrane raft organization), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0032374 (regulation of cholesterol transport), GO:0010874 (regulation of cholesterol efflux)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)