Protein: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (P70266)
Organism: Mus musculus (Mouse)
Function: Synthesis and degradation of fructose 2,6-bisphosphate
Sequence: MSREMGELTQTRLQKIWIPHSSSSSLLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYRNYEFFRPDNMEAQLIRKQCALAALKDVHKYLSREEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPDIIAENIKQVKLGSPDYIDCDQEKVLEDFLKRIECYEINYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHVQSRTAYYLMNIHVTPRSIYLCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQSISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNVEAVNTHRDKPENVDITREPEEALDTVPAHY
InterPro domains: - IPR013078: Histidine phosphatase superfamily, clade-1 (family) [253-439]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [41-252]
- IPR029033: Histidine phosphatase superfamily (homologous_superfamily) [250-470]
- IPR001345: Phosphoglycerate/bisphosphoglycerate mutase, active site (active_site) [256-265]
- IPR013079: 6-phosphofructo-2-kinase (domain) [31-251]
- IPR003094: Fructose-2,6-bisphosphatase (family) [32-453]
Interaction partners: - Fructose-1,6-bisphosphatase isozyme 2
- Fructose-1,6-bisphosphatase 1
- Fructose-2,6-bisphosphatase TIGAR
- ATP-dependent 6-phosphofructokinase, liver type
- ATP-dependent 6-phosphofructokinase, muscle type
- ATP-dependent 6-phosphofructokinase, platelet type
- cAMP-dependent protein kinase catalytic subunit beta
- cAMP-dependent protein kinase catalytic subunit alpha
- 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019203 (carbohydrate phosphatase activity), GO:0050308 (sugar-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0009894 (regulation of catabolic process), GO:0060322 (head development), GO:0048731 (system development), GO:0019637 (organophosphate metabolic process), GO:0048513 (animal organ development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0007420 (brain development), GO:0006140 (regulation of nucleotide metabolic process), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0043470 (regulation of carbohydrate catabolic process), GO:0007399 (nervous system development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0006796 (phosphate-containing compound metabolic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1900542 (regulation of purine nucleotide metabolic process), GO:0006110 (regulation of glycolytic process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:1903578 (regulation of ATP metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:1990234 (transferase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups)