Protein: Erythrocyte membrane protein 1, PfEMP1 (Q8I2E3)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MALGRPGGEDKYKNAKDAKHLLDSIGEEVYKEIVEKDDAEKYKEALKGKLSQASIWRETVSSLKTCDIIKYEGHKLLAARGDPCKKDTNGNDVDRFSVKEQAEYDNKKMKCSNGSNGSNGKNEGACASFRRLNLCKKNMEKIPTSSTKHDLLADVCMAANYEAQSLIRDHPKYKLKYSDSQLCTELARSFADIGDIVRGRDLYLGNPQEKGKRDELDKKLKDIFKQIHDDVTTNGKNKDALKTRYNDDAKGGHFYQLREDWWIANRHTVWEAITCDDDDKLGGYSYFRATCGSGNNATLARDKCTCNNGDVPTYFDYVPQYLRWFEEWAEDFCRKKKKYVDIVKTYCRGKDKNSEERYCSRNGFDCEKTKRAIGKLRYGKQCISCLYACNPYVEWIDNQRKQFLKQKQKYINVINGAPVSRRQKRDARNENYDGYESKFYKILKIDYQNVEDFLKKLSNEEICTKVQDTEGGKINFENVNSGASGTNVESQGTFYRSKYCQPCPHCGVKMKDGKWETKGEDDKCNIKLYRPKGGKDGTPIKILKSGEKQKEIETKLKAFCKTQNGGGGSDDCGGNSDSSLCEPWQCYQPEELTKDDQGEEDVDDLEYENEVINAGGLCILKKKKEKKTDNDPDEIQKTYNDFFNFWVAHMLKDSIYWKKKLQRCLQNGNRIKCGNQQCNNDCECFQKWIKQKKDEWDRIKQQFRKQDFRKQGENIAGGMLGKEIESPDFVLQEVLKLEFYKEKSEDGSAQDTENSLDEEEAEELKYIREIIEKKNQEPAGANGQKTIMDKLIDYEKDEAKKCKDCQETQPQPPGGDGVAKIGQPRSEVQPEEEEEEEEEEEEEDKEDDDDLDRKDAEDQEAEVETAKEGDVVTTKETTVEDPKVCDIVKTALENRENLQDACNLKYVKGKNYGWKCVPTTSGGDNNTPGETTGSESERAEPTRAKRAAPSSPSGKDTGSVCVPPRRRKLYIHDLQSLIGKDSTTPTQEDLLKWFIETAAIETFFLWHRYKKIKEKEIEEKRKRENGELPFLARSTSVEMKALSGAGGGPELTGSGSDDPNDPNNIYSGKIPPPFLRQMFYTLADYKDILFGDKGEKNGYSDIINGDKEMAQKEQNIKTAIESVFKPSGSSPPAPGKKNPVQTPKDWWTKYGPSIWEGMVCALTYKENSSGGEGKTIEKVKTADDKDLFDTLKGKYSDYEKVKLEDTSGAKPKDPKASPSGEKTTLVDFISRPPYFRYLEEWGQNFCKKRTEMLGKIKEECRGDRGGHQYCSGDGHDCTREDIKHNDMFSNLDCRPCYKQCRKYRKWIDIKFEEFRKQEKKYEEEHGKVITSSNNADDKNIYEKLKDYTSAANFLEALKHCKDGQTGGEKKSNDQDNKINFNDPKTTFGPLEYCKTCPPNKVNCNGRRRTNPCTPDNGKGNKWIEVFDKIPKNNGKTTTIDVHMIDRRGPFIKEYLKNSEKSFKDSYLFKSLRTEEWECRFNKEKKMDVCKLNKFDANIDLNEYTTFKVLIVYWLEDFLYSYYILKKKIELCTQNKEQTCSEGNSKNGCVCVKKWVEKKKKEWDQIKKHFNNREQKEGDDDMKSSVKMFLEDLQHLTELNKIMKPCTELYHFLKSLGCTETDSSENSKEDAIDCMLKKLEKKTESCSDEHSDQTHQTSCDSPPLVEDEDDTLHEEIEVKMPEICKNVVDTKKENDETGETCTSEDTITKETVETDSTDGPKQEEERIAPSAGDDGATRGPQEPSPKADSGDDNPETPQPKPPSNVFDNPHVKTALMSSTIMWSIGIGFAAFTYFYLKKKTKSTIDLLRVINIPKSDYDIPTKLSPNRYIPYTSGKYRGKRYIYLEGDSGTDSGYTDHYSDITSSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGNNTTASGNNTTASGNNTTASDTQNDIQNDGIPSSKITDNEWNTLKHDFISNMLQSEQPNDIPNDYTSGTIPTNTNITTTSRHNVDNNTNTTMSRDNMEEKPFITSIHDRDLYTGEEYNYDMSTNSGNNDLYNGKNNLYSGQNNVYSGIDPTSDNRGLTSGKHDSYSGIDLINDALSGNQPIDIYDELLKRKENELFGTNHTKKNTSTNSVAKNTNSDPIHNQLELFHKWLDRHRHMCEKWENHHERLAKLKEEWENETHSGNTHTSDSNKTLNTDVSIQIHMDNPKPINQFTNMDTILEDLEKYKEPYYDVQDDIYYDVNDHDASVVDSNAVDVPSKVQIEMDINTKLVKEKYPITDVWDI
InterPro domains: - IPR029210: Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment (domain) [17-54]
- IPR044932: Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment superfamily (homologous_superfamily) [1940-2160]
- IPR041480: Cysteine-rich interdomain region 1 gamma (domain) [1436-1493]
- IPR054595: Duffy-binding-like domain, C-terminal subdomain (domain) [327-1389]
- IPR008602: Duffy-antigen binding domain (domain) [124-1182]
- IPR029211: Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment (domain) [1778-2264]
- IPR042202: Duffy-antigen binding superfamily (homologous_superfamily) [87-1179]
- IPR004258: Duffy-binding-like domain (domain) [642-1652]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0050839 (cell adhesion molecule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0044403 (biological process involved in symbiotic interaction), GO:0007155 (cell adhesion), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0098609 (cell-cell adhesion), GO:0020013 (modulation by symbiont of host erythrocyte aggregation), GO:0044003 (modulation by symbiont of host process), GO:0052200 (response to host defenses), GO:0044406 (adhesion of symbiont to host), GO:0044650 (adhesion of symbiont to host cell), GO:0052572 (response to host immune response), GO:0020035 (adhesion of symbiont to microvasculature), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033644 (host cell membrane), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part), GO:0020002 (host cell plasma membrane), GO:0020030 (infected host cell surface knob)