Protein: Proprotein convertase subtilisin/kexin type 7 (A0A8M1P8P5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane
Sequence: MASCSSRVCLGLYPLLLLFSSSSSSCAPGRSWAVQLQPDSLSSAGSPDLLAQAVAQDVGLRSHGQIGQLEGHYLLCQDPAQGEDWRWMEAALDRHPHVAWHSQENVLRRSKRSVHFNDPKFPSQWHLHNDMKRGMDINVTGVWERNITGAGVTVVVVDDGIQHNLADIQPNYSPEGSYDLNSNDPDPMPHPDGPSDNHHGTRCAGEIAAVSNNSFCAVGVAYGSRVAGIRVLDGPLTDSMEAIAFNKHYQVNDIYSCSWGPDDDGRTVDGPHPLGKAALQHGVIAGRKGFGSIFIVASGNGGQNQDNCNYDGYANSIYTVTIGAVDESGRKPTYAEECASMLAVTFSSGNTPLRSIVTSDWSLQSGTGCTSGHTGTSAAAPLAAGMVALMLQVRPCLSWRDVQHIITYTATQHDLQADWVTNGAGFHHSHKYGFGLLNAWRLVNAAKVWESVPFLVSYQSPVLRVNEVITTSTNLTQTWNVSESDLQRSGMQTLEHVSVTLSIQHPRRGNLQILLLCPSGISSLIGARRALDVDSAGLTDWTFSTVRCWGEQAEGQYSLLIMDDAPLSSGILKSWKLTLYGSSLSHQQVTDRQRVVEEAMSGHYLSSSFSLPCPPGIDVPAEIVNPFTSSSLKSLLLLGCFTLFWSLYYTLEVVLTHWDWRGGCVRGRDGDAGYSRLSRDEAQTDPQQVEVLLETHSQDKVLLIADTHT
InterPro domains: - IPR023827: Peptidase S8, subtilisin, Asp-active site (active_site) [154-164]
- IPR000209: Peptidase S8/S53 domain (domain) [149-435]
- IPR038466: Peptidase S8, pro-domain superfamily (homologous_superfamily) [25-109]
- IPR022398: Peptidase S8, subtilisin, His-active site (active_site) [199-209]
- IPR036852: Peptidase S8/S53 domain superfamily (homologous_superfamily) [110-449]
- IPR034182: Kexin/furin catalytic domain (domain) [116-411]
- IPR002884: P domain (domain) [451-585]
- IPR008979: Galactose-binding-like domain superfamily (homologous_superfamily) [444-585]
- IPR032815: Peptidase S8, pro-domain (domain) [31-112]
- IPR015500: Peptidase S8, subtilisin-related (family) [149-390]
- IPR023828: Peptidase S8, subtilisin, Ser-active site (active_site) [375-385]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:1904888 (cranial skeletal system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0048703 (embryonic viscerocranium morphogenesis), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0001501 (skeletal system development), GO:0048562 (embryonic organ morphogenesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048706 (embryonic skeletal system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)