Protein: Menaquinone reductase, molybdopterin-binding-like subunit (Quinone reductase complex subunit B) (Type I cytochrome c3:menaquinone oxidoreductase subunit B) (Q72E84)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Component of the respiratory Qrc complex, that catalyzes the reduction of the menaquinone pool using electrons transferred from the reduced periplasmic cytochrome c3, and which is probably involved in sulfate respiration. Is likely essential for growth on H(2) or formate since the periplasmic hydrogenases and/or formate dehydrogenases act as primary electron donors for the Qrc complex. The function of the QrcB subunit is unknown; in the absence of a catalytic site, it may provide a structural scaffold for the other subunits.
Subcellular location: Periplasm {ECO:0000305|PubMed:20498375}.
Sequence: MALDRRGFLKFIGGATAGILATPVVWKGLDDVSIWSQNWSWIPRNIKGANSYVPTVSKLCPTGIGVRVRLVDGRPVRVIGNPEHPLSKGGVSSIAAAEVQMLYSPARMKRPLKRSPDGAYVMISWEEAEAMLLDGLKAAKGGDALACISGDDNGTINELLSAFVQQSGSKSFFLMPGEAQPAAKAWDLMGGEGQIGYDIEKSDFVLAIGANVLEAWGTAIRNRHAFGASHPHGAEPTAQFVYAGPVLNNTATGADDWLPIRPGTESAFALGLAHLLIKAGASSSAPDFDAFRSLAASFSPEKVAAQTGVDAKALTALAQALAKAKHPLVIVGSEFSQGAGAAPVMAGIALNMLLGSVNRDGGLRALPVARKVVPAGMDRKAMLQQDLTLWASAIASGKAKAPKAMLVYEANPVYALPQGSAFKDTLAKVPFKVAFTSFLDETAMQCDLVIPVSMGLERLDDVCTPYGCGEVVYSLATPVTAPLFDTKPAGDALIALGGKLGLDLGVASFEDMLKAKAAAHGADFDKLAEGTAFTSRATVGANLSFRPDVLSKALDVKAPALPLALAPVMKLNMGTSKTAIPPFNTKTIRRWEVQGKEGYVMLNGATARKLGLAQHDRVVLSNPTGKVTVRVNIFEGVMNDTVAMPLGFGHTAFDEFSKGKGENVMHLLAPSTEPVTGLAVWTGAGVNIAKA
InterPro domains: - IPR006963: Molybdopterin oxidoreductase, 4Fe-4S domain (domain) [50-106]
- IPR006656: Molybdopterin oxidoreductase (domain) [107-458]
- IPR009010: Aspartate decarboxylase-like domain superfamily (homologous_superfamily) [588-691]
- IPR006657: Molybdopterin dinucleotide-binding domain (domain) [586-677]
- IPR006311: Twin-arginine translocation pathway, signal sequence (conserved_site) [1-27]
- IPR050612: Prokaryotic Molybdopterin Oxidoreductases (family) [1-691]
- IPR053557: Molybdopterin-binding Qrc complex component (family) [1-691]
Interaction partners: - Menaquinone reductase, iron-sulfur cluster-binding subunit
- Menaquinone reductase, integral membrane subunit
- Reductase, iron-sulfur binding subunit, putative
- Iron-sulfur cluster-binding protein
- Heterodisulfide reductase, iron-sulfur-binding subunit, putative
- Cytochrome c nitrite reductase subunit NrfH
- Reductase, transmembrane subunit, putative
- Pyridine nucleotide-disulfide oxidoreductase
- Formate dehydrogenase, beta subunit, putative
- Formate dehydrogenase, beta subunit, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006790 (sulfur compound metabolic process), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051262 (protein tetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0042597 (periplasmic space), GO:1990204 (oxidoreductase complex)