Protein: Histone-lysine N-methyltransferase, H3 lysine-37 specific (Q9Y7Q6)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Histone lysine methyltransferase that specifically mono-, di-, and trimethylates 'Lys-37' of histone H3 to regulate sporulation
Subcellular location: Cytoplasm. Nucleus
Sequence: MRIPVIRSPLEIRDTERKGRGVFALEPIPAQTCIEISPVLMFSKEEYEQHGQYTVLNEYTYVWSEGKQGLALGLGSMFNHDRHPNVYWKKDNRNNYISYYTLREIKTNEELCISYGDHLWFEDEASSASRISPNEENEDFPLQNISL
InterPro domains: - IPR001214: SET domain (domain) [8-122]
- IPR046341: SET domain superfamily (homologous_superfamily) [6-127]
- IPR009207: Histone-lysine N-methyltransferase, H3 lysine-37 specific (family) [1-140]
Interaction partners: - tRNA-specific adenosine deaminase subunit tad2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0031137 (regulation of conjugation with cellular fusion), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0090068 (positive regulation of cell cycle process), GO:0035556 (intracellular signal transduction), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009966 (regulation of signal transduction), GO:0045786 (negative regulation of cell cycle), GO:0051098 (regulation of binding), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0010033 (response to organic substance), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:1901989 (positive regulation of cell cycle phase transition), GO:0071310 (cellular response to organic substance), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:1902532 (negative regulation of intracellular signal transduction), GO:0045931 (positive regulation of mitotic cell cycle), GO:1902531 (regulation of intracellular signal transduction), GO:1901988 (negative regulation of cell cycle phase transition), GO:1902750 (negative regulation of cell cycle G2/M phase transition), GO:0051058 (negative regulation of small GTPase mediated signal transduction), GO:1902749 (regulation of cell cycle G2/M phase transition), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902807 (negative regulation of cell cycle G1/S phase transition), GO:1902751 (positive regulation of cell cycle G2/M phase transition), GO:0010389 (regulation of G2/M transition of mitotic cell cycle), GO:0046578 (regulation of Ras protein signal transduction), GO:0010971 (positive regulation of G2/M transition of mitotic cell cycle), GO:0046580 (negative regulation of Ras protein signal transduction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:1990234 (transferase complex), GO:0035097 (histone methyltransferase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0048188 (Set1C/COMPASS complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000228 (nuclear chromosome), GO:0000793 (condensed chromosome), GO:0000794 (condensed nuclear chromosome)