Protein: Endothelin-converting enzyme 2 (ECE-2) (EC 3.4.24.71) (F1N476)
Organism: Bos taurus (Bovine)
Function: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing (By similarity).
Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:12054617}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:12054617}.
Sequence: MSVALQELGGGGNMVEYKRATLRDEDAPETPVEGGASPDAVEAGFRKRTSRLLGLHTQLELVLAGVSLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAERKTQRFYLSCLQVERIEELGAQPLRDLIDKIGGWNVTGPWDQDNFMEVLKAVAGTYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGQPTSTREQMRQVLELEIQLANITVPQDQRRDEEKIYHKMSIAELQALAPSMDWLEFLSFLLSPLELGDSEPVVVYGTDYLQQVSELINRTEPSVLNNYLIWNLVQKTTSSLDHRFESAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEEALGHLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYTCNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACIEEQYSQYQVNGEKLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNSGQLCEVW
InterPro domains: - IPR000718: Peptidase M13 (family) [69-765]
- IPR018497: Peptidase M13, C-terminal domain (domain) [553-764]
- IPR008753: Peptidase M13, N-terminal domain (domain) [116-502]
- IPR042089: Peptidase M13, domain 2 (homologous_superfamily) [142-548]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [105-765]
Interaction partners: - EEF1A lysine methyltransferase 4
- Endothelin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0008233 (peptidase activity), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0006807 (nitrogen compound metabolic process), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0016486 (peptide hormone processing), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043603 (amide metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0006518 (peptide metabolic process), GO:0006508 (proteolysis), GO:0051604 (protein maturation), GO:0010467 (gene expression), GO:0016485 (protein processing), GO:0140448 (signaling receptor ligand precursor processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)