Protein: Intercellular adhesion molecule 1 (ICAM-1) (MALA-2) (MyD10) (CD antigen CD54) (P13597)
Organism: Mus musculus (Mouse)
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity).
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MASTRAKPTLPLLLALVTVVIPGPGDAQVSIHPREAFLPQGGSVQVNCSSSCKEDLSLGLETQWLKDELESGPNWKLFELSEIGEDSSPLCFENCGTVQSSASATITVYSFPESVELRPLPAWQQVGKDLTLRCHVDGGAPRTQLSAVLLRGEEILSRQPVGGHPKDPKEITFTVLASRGDHGANFSCRTELDLRPQGLALFSNVSEARSLRTFDLPATIPKLDTPDLLEVGTQQKLFCSLEGLFPASEARIYLELGGQMPTQESTNSSDSVSATALVEVTEEFDRTLPLRCVLELADQILETQRTLTVYNFSAPVLTLSQLEVSEGSQVTVKCEAHSGSKVVLLSGVEPRPPTPQVQFTLNASSEDHKRSFFCSAALEVAGKFLFKNQTLELHVLYGPRLDETDCLGNWTWQEGSQQTLKCQAWGNPSPKMTCRRKADGALLPIGVVKSVKQEMNGTYVCHAFSSHGNVTRNVYLTVLYHSQNNWTIIILVPVLLVIVGLVMAASYVYNRQRKIRIYKLQKAQEEAIKLKGQAPPP
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [28-480]
- IPR048679: Intercellular adhesion molecule 1/3/5, D2 domain (domain) [221-310]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [28-479]
- IPR007110: Immunoglobulin-like domain (domain) [315-477]
- IPR047012: Intercellular adhesion molecule/vascular cell adhesion molecule (family) [12-527]
- IPR003987: Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal (domain) [35-159]
- IPR003599: Immunoglobulin domain subtype (domain) [33-479]
- IPR013768: Intercellular adhesion molecule, N-terminal (domain) [25-114]
- IPR003988: Intercellular adhesion molecule (domain) [121-199]
Interaction partners: - Integrin beta-2
- Integrin alpha-M
- Integrin alpha-L
- Integrin beta-2-like protein
- Vascular cell adhesion protein 1
- Ezrin
- T-lymphocyte activation antigen CD80
- CD44 antigen
- Intercellular adhesion molecule 2
- Moesin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003008 (system process), GO:0003012 (muscle system process), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003013 (circulatory system process), GO:0055006 (cardiac cell development), GO:0042692 (muscle cell differentiation), GO:0008015 (blood circulation), GO:0055001 (muscle cell development), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0006936 (muscle contraction), GO:0003015 (heart process), GO:0035051 (cardiocyte differentiation), GO:0007507 (heart development), GO:0006941 (striated muscle contraction), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0060047 (heart contraction), GO:0055013 (cardiac muscle cell development), GO:0055012 (ventricular cardiac muscle cell differentiation), GO:0060048 (cardiac muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)