Protein: Nuclear factor 1 X-type (P70257)
Organism: Mus musculus (Mouse)
Function: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Isoform NFIX1 acts as a transcriptional activator while isoform NFIX3 acts as a repressor
Subcellular location: Nucleus
Sequence: MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSSTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKTTSTAPDGAALTPPSPSFTTTGASSANRFVGIGPRDG
InterPro domains: - IPR019548: CTF transcription factor/nuclear factor 1, N-terminal (domain) [8-46]
- IPR003619: MAD homology 1, Dwarfin-type (domain) [67-175]
- IPR020604: CTF transcription factor/nuclear factor 1, DNA-binding domain (domain) [1-194]
- IPR000647: CTF transcription factor/nuclear factor 1 (family) [4-487]
- IPR019739: CTF transcription factor/nuclear factor 1, conserved site (conserved_site) [36-47]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003682 (chromatin binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0048589 (developmental growth), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0008283 (cell population proliferation), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0035264 (multicellular organism growth), GO:0021700 (developmental maturation), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044237 (cellular metabolic process), GO:0098727 (maintenance of cell number), GO:0009893 (positive regulation of metabolic process), GO:0001503 (ossification), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0019827 (stem cell population maintenance), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0061351 (neural precursor cell proliferation), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0001708 (cell fate specification), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0060041 (retina development in camera-type eye), GO:0021680 (cerebellar Purkinje cell layer development), GO:0021696 (cerebellar cortex morphogenesis), GO:0071695 (anatomical structure maturation), GO:0000902 (cell morphogenesis), GO:0021549 (cerebellum development), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0021988 (olfactory lobe development), GO:0007611 (learning or memory), GO:0048469 (cell maturation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0030900 (forebrain development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0021543 (pallium development), GO:0016043 (cellular component organization), GO:0021587 (cerebellum morphogenesis), GO:0042246 (tissue regeneration), GO:0030282 (bone mineralization), GO:0016477 (cell migration), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0021766 (hippocampus development), GO:0021575 (hindbrain morphogenesis), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0021772 (olfactory bulb development), GO:0021987 (cerebral cortex development), GO:1901576 (organic substance biosynthetic process), GO:1903047 (mitotic cell cycle process), GO:0009611 (response to wounding), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0021537 (telencephalon development), GO:0046483 (heterocycle metabolic process), GO:0014009 (glial cell proliferation), GO:0030902 (hindbrain development), GO:0021695 (cerebellar cortex development), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0022037 (metencephalon development), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0060249 (anatomical structure homeostasis), GO:0009891 (positive regulation of biosynthetic process), GO:0048872 (homeostasis of number of cells), GO:0045165 (cell fate commitment), GO:0061061 (muscle structure development), GO:0036302 (atrioventricular canal development), GO:0021697 (cerebellar cortex formation), GO:0036075 (replacement ossification), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0021681 (cerebellar granular layer development), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0044770 (cell cycle phase transition), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0050877 (nervous system process), GO:0001894 (tissue homeostasis), GO:0080090 (regulation of primary metabolic process), GO:0031099 (regeneration), GO:0000278 (mitotic cell cycle), GO:0021510 (spinal cord development), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0048705 (skeletal system morphogenesis), GO:0021533 (cell differentiation in hindbrain), GO:0048665 (neuron fate specification), GO:0097402 (neuroblast migration), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0014016 (neuroblast differentiation), GO:0043067 (regulation of programmed cell death), GO:0048880 (sensory system development), GO:0010001 (glial cell differentiation), GO:0010468 (regulation of gene expression), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0071772 (response to BMP), GO:0021761 (limbic system development), GO:0001501 (skeletal system development), GO:0090304 (nucleic acid metabolic process), GO:0072359 (circulatory system development), GO:0018130 (heterocycle biosynthetic process), GO:0021591 (ventricular system development), GO:0060349 (bone morphogenesis), GO:0007417 (central nervous system development), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0007507 (heart development), GO:0021781 (glial cell fate commitment), GO:0007405 (neuroblast proliferation), GO:0050890 (cognition), GO:1901215 (negative regulation of neuron death), GO:0048663 (neuron fate commitment), GO:0043403 (skeletal muscle tissue regeneration), GO:0019438 (aromatic compound biosynthetic process), GO:0021846 (cell proliferation in forebrain), GO:0140014 (mitotic nuclear division), GO:0007423 (sensory organ development), GO:0021782 (glial cell development), GO:1901214 (regulation of neuron death), GO:0007612 (learning), GO:0035914 (skeletal muscle cell differentiation), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0007613 (memory), GO:0044772 (mitotic cell cycle phase transition), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0021872 (forebrain generation of neurons), GO:0051254 (positive regulation of RNA metabolic process), GO:0060348 (bone development), GO:0001958 (endochondral ossification), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0031214 (biomineral tissue development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0048873 (homeostasis of number of cells within a tissue), GO:0007517 (muscle organ development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0071363 (cellular response to growth factor stimulus), GO:0042981 (regulation of apoptotic process), GO:0016070 (RNA metabolic process), GO:0010458 (exit from mitosis), GO:0048709 (oligodendrocyte differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0043583 (ear development), GO:0043523 (regulation of neuron apoptotic process), GO:0150063 (visual system development), GO:0007519 (skeletal muscle tissue development), GO:0043524 (negative regulation of neuron apoptotic process), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)