Protein: DNA damage-binding protein CMR1 (Changed mutation rate protein 1) (Q12510)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA in vitro. May be involved in DNA-metabolic processes.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}.
Sequence: MPELTEFQKKRLENIKRNNDLLKKLHLSGVASQIKHEAGVLEKSRAPAKKKQKTTNTRATKSASPTLPTRRSRRLRGESADDVKGIPNVNDNQLLKMGSPDGQDKNFIDAIKEKPVIGDVKLSDLIKDEDESALLEKFKRFNNGNFSSGDFFEEIKKRQGDVTGMDEFDLDLYDVFQPNEIKITYERISATYFHPAMEKKLIIAGDTSGTVGFWNVRDEPLADSEEDRMEEPDITRVKLFTKNVGRIDCFPADTSKILLTSYDGSIRSVHLNNLQSEEVLTLKNEYDDSLGISDCQFSYENPNVLFLTTLGGEFTTFDTRVKKSEYNLRRLADKKIGSMAINPMRPYEIATGSLDRTLKIWDTRNLVKKPEWSQYEDYPSHEIVSTYDSRLSVSAVSYSPTDGTLVCNGYDDTIRLFDVKSRDHLSAKLEPKLTIQHNCQTGRWTSILKARFKPNKNVFAIANMKRAIDIYNSEGQQLAHLPTATVPAVISWHPLRNWIAGGNSSGKIFLFTDDSGTIKQEE
InterPro domains: - IPR001680: WD40 repeat (repeat) [178-512]
- IPR019775: WD40 repeat, conserved site (conserved_site) [349-363]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [180-515]
- IPR050853: WD repeat-containing DNA damage-binding protein (family) [1-512]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [185-518]
Interaction partners: - Replication factor A protein 2
- DNA mismatch repair protein MSH6
- Replication factor A protein 1
- Replication factor A protein 3
- Histone H4
- RING-box protein HRT1
- DNA repair protein RAD51
- DNA repair and recombination protein RAD52
- ISWI chromatin-remodeling complex ATPase ISW1
- ATPase histone chaperone YTA7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0003712 (transcription coregulator activity), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003713 (transcription coactivator activity), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0000217 (DNA secondary structure binding), GO:0003697 (single-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0104004 (cellular response to environmental stimulus), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0071478 (cellular response to radiation), GO:0009416 (response to light stimulus), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0009411 (response to UV), GO:0006281 (DNA repair), GO:0071482 (cellular response to light stimulus), GO:0006284 (base-excision repair), GO:0070914 (UV-damage excision repair), GO:0034644 (cellular response to UV), GO:0006290 (pyrimidine dimer repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0140535 (intracellular protein-containing complex), GO:0031248 (protein acetyltransferase complex), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0000123 (histone acetyltransferase complex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:1902493 (acetyltransferase complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0070775 (H3 histone acetyltransferase complex), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)