Protein: Cytochrome P450 315a1, mitochondrial (EC 1.14.15.-) (CYPCCCXVA1) (Protein shadow) (Q9VGH1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for CNS development: midline glial cells. Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity. May be involved in the breakdown of synthetic insecticides.
Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:14610274}.
Sequence: MTEKRERPGPLRWLRHLLDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCIRVQEDQRRPHDEALYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKERATNDSRLMHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRPRTE
InterPro domains: - IPR001128: Cytochrome P450 (family) [63-500]
- IPR002401: Cytochrome P450, E-class, group I (family) [91-489]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [52-520]
- IPR050479: Cytochrome P450, families 11 and 27 (family) [56-518]
Interaction partners: - Ecdysone oxidase
- Spookier
- Cytochrome P450 307a1
- Cytochrome P450 302a1, mitochondrial
- Ecdysone 20-monooxygenase
- Cholesterol 7-desaturase nvd
- Cytochrome P450 306a1
- Probable cytochrome P450 303a1
- Probable cytochrome P450 6t3
- Short-chain dehydrogenase/reductase)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0004497 (monooxygenase activity), GO:0016709 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0042440 (pigment metabolic process), GO:0071704 (organic substance metabolic process), GO:0009791 (post-embryonic development), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0042180 (cellular ketone metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0002165 (instar larval or pupal development), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0006935 (chemotaxis), GO:1902652 (secondary alcohol metabolic process), GO:0030097 (hemopoiesis), GO:1901362 (organic cyclic compound biosynthetic process), GO:0008205 (ecdysone metabolic process), GO:0008202 (steroid metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0016125 (sterol metabolic process), GO:1902652 (secondary alcohol metabolic process), GO:0010941 (regulation of cell death), GO:0042742 (defense response to bacterium), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0042181 (ketone biosynthetic process), GO:0046165 (alcohol biosynthetic process), GO:0045456 (ecdysteroid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006697 (ecdysone biosynthetic process), GO:0006694 (steroid biosynthetic process), GO:0016126 (sterol biosynthetic process), GO:1902653 (secondary alcohol biosynthetic process), GO:0006697 (ecdysone biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)