wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Melanocortin receptor 5 (Q8JGW2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MHVNSSPASYILNATETPSHNKPKACEQLNIATEVFLILGIVSLLENILVICAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETIVIYLLTNRQLVVEDHFIRQMDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAALIIGGIWTFCTGCGIVFIIYSDNTSVIVCLVSMFFIMLALMASLYSHMFMLARSHVKRIAALPGYNSIHQRASMKAAVTLTILLGIFIVCWAPFFLHLILMISCPRNLYCMCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTLKEIICCYSLRNVFGMSR
InterPro domains: - IPR000621: Melanocortin 5 receptor (family) [16-315]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [46-288]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [31-303]
- IPR001671: Melanocortin/ACTH receptor (family) [56-305]
- IPR001908: Melanocortin receptor 3-5 (family) [173-304]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050795 (regulation of behavior), GO:0044248 (cellular catabolic process), GO:0006914 (autophagy), GO:0090398 (cellular senescence), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0006112 (energy reserve metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Troponin T, slow skeletal muscle (B3DG30)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Sequence: MSDVEEEYEEQAEAEEEEEETTEEAGTEQQDYTEYQEEAQEEEEERPRPKPMVPQLAPPKIPEGERVDFDDIHRKRMEKDLLELQTLIEAHFEQRKKEEEELIGLKDRIERRRFERAEQQRVRAEKERDRQTRIAEERQRKEDEEAKKRADDEAKKKKVLSNMGANFGGFLAKAEQKRGKRLTGREIKRKTLSERRAPLGIENMREDALRQRAQEMWNWIYELESEKFDLLDQMKKQKYEIVVLLNRISHAQKFKKGHGKGKVGGRWK
InterPro domains: - IPR001978: Troponin (family) [75-204]
- IPR027707: Troponin T (family) [6-268]
- IPR038077: Troponin domain superfamily (homologous_superfamily) [154-268]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding), GO:0005523 (tropomyosin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0043502 (regulation of muscle adaptation), GO:0044057 (regulation of system process), GO:0090257 (regulation of muscle system process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0036379 (myofilament), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0005865 (striated muscle thin filament), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)
Protein: Sidoreflexin (Q6DC00)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine
Subcellular location: Mitochondrion membrane; Multi- pass membrane protein
Sequence: MAATISTSINIKEPRWDQGTFVGRAKHFFTVTDPRNILLSNKQLEKAHQIIQDYKKGVVAADLTEDELWRAKYVFDSAFHPDTGEKMLLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAIVNYTNRSGDAPITVNQLGTAYVSATTGAVATALGPNALAKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKHGIPVTDENDNRLGESSKAAQQAITQVVVSRILMASPGMAIPPFLMNSLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMAVSRLEPELQEKIRASHPGVETVYFNKGL
InterPro domains: - IPR004686: Tricarboxylate/iron carrier (family) [9-322]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity), GO:0022889 (serine transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0044281 (small molecule metabolic process), GO:1990542 (mitochondrial transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006730 (one-carbon metabolic process), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0003333 (amino acid transmembrane transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015804 (neutral amino acid transport), GO:0046942 (carboxylic acid transport), GO:0032329 (serine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Proopiomelanocortin b (A0A8M1NCD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Endogenous opiate
Subcellular location: Secreted
Sequence: MFCPSWLLAAAVLCFHSPHVDGGRCSGLIDCMDLESNEHKLQCLRKCRSDQESSRNIRVSSSEHQSSEEQVEEQSLSLGLLLSALSPDSIELQNPTAEAPHGDERRSYSMEHFRWGKPMGRKRRPVKVLSNGALEEEPEESEESVRVERGQSGTLEVQHRNNVKNNGKYRMTHFRWNAPPDKRYGGLMRPYLDESHKPLITLIRNAIGNGQQFTD
InterPro domains: - IPR013532: Opiodes neuropeptide (domain) [184-214]
- IPR013531: Pro-opiomelanocortin/corticotropin, ACTH, central region (domain) [106-183]
- IPR050878: Pro-opiomelanocortin-derived peptides (family) [7-212]
- IPR001941: Pro-opiomelanocortin (family) [108-189]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity), GO:0005184 (neuropeptide hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0050793 (regulation of developmental process), GO:0006950 (response to stress), GO:0033059 (cellular pigmentation), GO:0033555 (multicellular organismal response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0051875 (pigment granule localization), GO:0051648 (vesicle localization), GO:0007186 (G protein-coupled receptor signaling pathway), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:0007218 (neuropeptide signaling pathway), GO:0032400 (melanosome localization), GO:2000736 (regulation of stem cell differentiation), GO:1902036 (regulation of hematopoietic stem cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: G-protein coupled receptor 12 (E7FFG5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MSEEVSVSPSWLAQEPTWGSSGAGSIENITVGTYSPAVILPARPPTELLVNPWDIVLCSSGTLIACENALVVLVIWQNPALRAPMFLLIGSLALADLLAGLGLVLHFTFAYLLRSDSAQLLTVGLVVASFSASVFSLLAITIDRYLSLYYALTYNSERTAAFTYTMLVLLWGVSLCLGLLPVTGVNCLGQEVNCSVVWPLTKNNVAVLSVSFLLLFGLMLQLYVQICKIVMRHAHQIALQHHFLAASPHYVTTRKGVSTLAIILGTFAACWMPFTVYSLIADYTYPPLYTYATLVPATYNSVINPVIYAFRNQEIQKALWLVCCGCIPASVAHRARTPSDV
InterPro domains: - IPR000276: G protein-coupled receptor, rhodopsin-like (family) [67-316]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [67-308]
- IPR000723: G protein-coupled receptor 3/6/12 orphan (family) [52-320]
- IPR000599: G protein-coupled receptor 12 (family) [27-288]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0051240 (positive regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055074 (calcium ion homeostasis), GO:0006874 (intracellular calcium ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0051480 (regulation of cytosolic calcium ion concentration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Large ribosomal subunit protein eL22 (Q32Q51)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
Subcellular location: Cytoplasm
Sequence: MAPIKKQVTKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVSIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANTKESYELRYFQINQDEEEEDED
InterPro domains: - IPR038526: Large ribosomal subunit protein eL22 superfamily (homologous_superfamily) [8-127]
- IPR002671: Large ribosomal subunit protein eL22 (family) [5-125]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030097 (hemopoiesis), GO:0060216 (definitive hemopoiesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: C-C motif chemokine (B3DGM0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MSRISACVMVLTIVALGLLCTDAAAVSCCRKYTKGMIPMSLIKGYSIQTITRSCHINAVIFHTNGGKNICTDPSKGWVMESIRKLREKVQAINKKNSKA
InterPro domains: - IPR039809: Chemokine beta/gamma/delta (family) [6-88]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [25-94]
- IPR000827: CC chemokine, conserved site (conserved_site) [28-71]
- IPR001811: Chemokine interleukin-8-like domain (domain) [25-85]
Interaction partners: - C-C chemokine receptor type 6
- C-C chemokine receptor type 6a
- C-C motif chemokine
- Stromal cell-derived factor 1
- C-X-C chemokine receptor type 3
- Relaxin family peptide receptor 2,-like
- Chemokine (C-X-C motif) ligand 8a
- C-C motif chemokine
- Stromal cell-derived factor 1
- Chemokine (C-X-C motif) ligand 18b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0042056 (chemoattractant activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0097529 (myeloid leukocyte migration), GO:0002523 (leukocyte migration involved in inflammatory response), GO:0009611 (response to wounding), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0048731 (system development), GO:0071674 (mononuclear cell migration), GO:0006952 (defense response), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0071621 (granulocyte chemotaxis), GO:0060326 (cell chemotaxis), GO:0097530 (granulocyte migration), GO:0006954 (inflammatory response), GO:0030593 (neutrophil chemotaxis), GO:1990266 (neutrophil migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Dopamine D4a receptor (A0A2R8RMG6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MPANLTISTHTTNYNFPALIFGILLIIIIICGNVLVCLSVYTEKALKTTTNYFIVSLAVADLLLAVLVLPLFVYAEFQDGVWSLNMTVCDGLMTMDVMLCTASIFNLCAISIDRFIAVSIPLNYNRKHVDQRQIVLLSATWILALAVASPVMFGINNVPNRDHSECKLEDNNYVIYSSVCSFFVPCPIMLLLYCGMFRGLRNWEEARKAKLRSNMEACRKLQEAAASLQPLSGLPPPLPPVIEKDITLEELDQDHYPDPDSPDPVSMLAYPGGGYNQDQNQNRQRKRAKINGRERKAMRVLPVVVGAFLFCWTPFFVVHTMRALCEDCEIPGSVTSIVTWLGYVNSAINPIIYTVFNTEFRKFFRKFLPTLPGCC
InterPro domains: - IPR000929: Dopamine receptor family (family) [37-369]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [17-368]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [32-353]
- IPR002185: Dopamine D4 receptor (family) [79-212]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0004935 (adrenergic receptor activity), GO:0004936 (alpha-adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0045165 (cell fate commitment), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0001708 (cell fate specification), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0048665 (neuron fate specification), GO:0007399 (nervous system development), GO:0048663 (neuron fate commitment), GO:0021514 (ventral spinal cord interneuron differentiation), GO:0021522 (spinal cord motor neuron differentiation), GO:0007417 (central nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0021520 (spinal cord motor neuron cell fate specification), GO:0048699 (generation of neurons), GO:0021953 (central nervous system neuron differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: RNA helicase (Q6NWH7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MPGYSDRDRGRDRGSYSSGPPRFGGSRNGPPPAKKFGNPGDRLRKKHWNLDELPKFEKNFYQENPDVARRSAQEVEHYRRSKEITVKGRDGPKPIVKFHEANFPKYVMDVITKQNWTDPTPIQAQGWPVALSGKDMVGIAQTGSGKTLSYLLPAIVHINHQPFLEHGDGPICLVLAPTRELAQQVQQVAAEYGKASRIKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKEYIQINVGALQLSANHNILQIVDVCNDGEKEDKLIRLLEEIMSEKENKTIIFVETKRRCDDLTRRMRRDGWPAMGIHGDKNQQERDWVLNEFKYGKAPILIATDVASRGLDVEDVKFVINFDYPNNSEDYIHRIGRTARSQKTGTAYTFFTPNNMKQAHDLVSVLREANQAINPKLIQMAEDRGGKSNWSFKGRTRWRV
InterPro domains: - IPR011545: DEAD/DEAH-box helicase domain (domain) [120-290]
- IPR001650: Helicase, C-terminal domain-like (domain) [329-477]
- IPR014014: RNA helicase, DEAD-box type, Q motif (domain) [96-124]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [68-484]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [115-318]
- IPR000629: ATP-dependent RNA helicase DEAD-box, conserved site (conserved_site) [248-256]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:1901532 (regulation of hematopoietic progenitor cell differentiation), GO:2000736 (regulation of stem cell differentiation), GO:1902036 (regulation of hematopoietic stem cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Bone Gla protein (Q4G6A6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MKSLTVLIFCCLMTVCLSAGLPDSSDTKPLSAAESPNHEGVFVKRDVASIIMRQKRAGTAPGDLTPFQLESLREVCETNVACEHMMDTSGIIAAYKTYYGPIPF
InterPro domains: - IPR039176: Osteocalcin (family) [8-104]
- IPR000294: Gamma-carboxyglutamic acid-rich (GLA) domain (domain) [39-100]
- IPR058704: Osteocalcin-like, C-terminal domain (domain) [68-103]
- IPR035972: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily (homologous_superfamily) [67-101]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0001503 (ossification), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0048513 (animal organ development), GO:0030282 (bone mineralization), GO:0009612 (response to mechanical stimulus), GO:0031214 (biomineral tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)