Protein: Exocyst complex component exo84 (O14226)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
Subcellular location: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Cell periphery. The polarization of EXO84 requires actin cables (By similarity). {ECO:0000250}.
Sequence: MPDNPSSFEDEFMKSNHLSVASESIPNESQRQSPTRLRVGTSKTDDIYRQKRQTKHIISQNEVFLQPKFFDNQNFDAQSYLNDVLQDLSEDEFVSLYNKLLRIHMGVRKNLEKNFYKNLNEYVFISGEVESMTSDFKKFQSLLKTLETDIEGLNLVDHTHDPSDESIKQTVQRLRSSIEGLDEAFWEAPQRQLICEQYNWMLINIDNQRPKLLVNMLLFNDRLLVTTSHMKEVDFPAKQQVLYNWNLTEISISSIETYGPAGAEMLQKEKEVSLYKLSINHNNKTTLLAVHNSEERDYMVRQARHHQLQELENWSRKHDEDLEFSRELEYHTKSEQADMCSYTSFQVLCKNLDTQDILQAYAKQRNMVKEISMQFDHLDIQISLQEFTDAIRNLALIQNKLERGNLNELFAEFFADKLHNRKRKVTEILLHQLGFKGISLSHGKEIVRYLRSLGHEKEGQGVFMKSRTLLIKEKCLNVQLEKDTPNFIDACAFIVFRCLAQTTSSYLQLFELKKLDPAYRNWIFQQIEALVDLIENQYKHLAHDRSYTDAVSKIMTYNTELKEAKIDAMPILQRLFDVHSKDLK
InterPro domains: - IPR042561: Exocyst component Exo84, C-terminal, subdomain 1 (homologous_superfamily) [359-478]
- IPR033961: Exocyst complex component Exo84 (family) [60-577]
- IPR042560: Exocyst component Exo84, C-terminal, subdomain 2 (homologous_superfamily) [482-583]
- IPR032403: Exocyst component Exo84, C-terminal (domain) [370-563]
- IPR016159: Cullin repeat-like-containing domain superfamily (homologous_superfamily) [364-582]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [186-310]
Interaction partners: - Exocyst complex component exo70
- Exocyst complex component sec6
- Exocyst complex component sec10
- Exocyst complex component sec15
- Exocyst complex component sec8
- Exocyst complex component sec5
- Uncharacterized protein C17G8.12
- F-box protein pof6
- Protein transport protein sec9
- Cell division control protein 42 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)