Protein: GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) (Q6Y7W6)
Organism: Homo sapiens (Human)
Function: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay. Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA. May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors.
Sequence: MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY
InterPro domains: - IPR051640: GRB10-interacting GYF (family) [1-1277]
- IPR003169: GYF domain (domain) [533-589]
- IPR035445: GYF-like domain superfamily (homologous_superfamily) [523-594]
Interaction partners: - Eukaryotic translation initiation factor 4E type 2
- Growth factor receptor-bound protein 10
- E3 ubiquitin-protein ligase ZNF598
- Probable ATP-dependent RNA helicase DDX6
- F-box only protein 7
- GRB10-interacting GYF protein 1
- Ubiquitin carboxyl-terminal hydrolase isozyme L1
- Leucine-rich repeat serine/threonine-protein kinase 2
- 85/88 kDa calcium-independent phospholipase A2
- Serine protease HTRA2, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071704 (organic substance metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0003008 (system process), GO:0050879 (multicellular organismal movement), GO:0009791 (post-embryonic development), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0035264 (multicellular organism growth), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0007631 (feeding behavior), GO:0030534 (adult behavior), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0060249 (anatomical structure homeostasis), GO:0007626 (locomotory behavior), GO:0048872 (homeostasis of number of cells), GO:0051726 (regulation of cell cycle), GO:0050881 (musculoskeletal movement), GO:0033554 (cellular response to stress), GO:0021517 (ventral spinal cord development), GO:0045786 (negative regulation of cell cycle), GO:0007166 (cell surface receptor signaling pathway), GO:0050877 (nervous system process), GO:0001894 (tissue homeostasis), GO:0010564 (regulation of cell cycle process), GO:0000278 (mitotic cell cycle), GO:0021510 (spinal cord development), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:0021522 (spinal cord motor neuron differentiation), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0021515 (cell differentiation in spinal cord), GO:0050905 (neuromuscular process), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0008344 (adult locomotory behavior), GO:1901987 (regulation of cell cycle phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0007417 (central nervous system development), GO:0048873 (homeostasis of number of cells within a tissue), GO:0030182 (neuron differentiation), GO:1901988 (negative regulation of cell cycle phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0021953 (central nervous system neuron differentiation), GO:0044774 (mitotic DNA integrity checkpoint signaling), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0044819 (mitotic G1/S transition checkpoint signaling), GO:0050885 (neuromuscular process controlling balance), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048699 (generation of neurons), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:1902807 (negative regulation of cell cycle G1/S phase transition), GO:0000077 (DNA damage checkpoint signaling), GO:0044773 (mitotic DNA damage checkpoint signaling), GO:2000134 (negative regulation of G1/S transition of mitotic cell cycle), GO:0031571 (mitotic G1 DNA damage checkpoint signaling), GO:0048009 (insulin-like growth factor receptor signaling pathway), GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)