Protein: Structural maintenance of chromosomes protein (Q57UB5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
Sequence: MYIKNILISGFRSYREQAFEQELSPKNNVIVGKNGAGKSNFFAAIQFVLCEKFMNLSSVERKDLFHVGSGRPALPIFVEIIFDNSDGRLVIPGKSAVNEVRIRRTLGLKQDEFRVNDKRFTATDIRQLLESAGFSSTNPYYIVEQGQISSLANMSDEERFQLIKDVAGTRVYEVRRKESEKILEETEVQHEKIGESIAQLEERLEELRSESDELMSFQEIDKKRKCVQYCILNSDLNAAREELRRLDDERNSYMSRSGRDHYDIDEAKAIISEAESEIRNCDQRILRLEGELQDLDTKRGTLMREKEIVQLNCMSSLNTMKRTESVKTNVLKRVGELNKQIAETNAGLKKKLAIIQQEQLTVDQKSEELSAIEGKLKALEARRARQLLFKNKQERDNWLAEESNRNRKTIENYKHELKFTCSEIQKVEKQIEDEETEQKNWEESLKKSDSVITELKSKYEETMAFRNSLSVKKGDLWREQSALVQTVRTLRENHNKARSQLEKVIRSDVRQGLQSLKEVLDELADPSLTNAVHGQLIELIGVSNGYETAVEVTAGNSLFNVVVDSFEVSAILLENMNSRKKPGRISFFPMDTCRGTVTRFGEGVECSSLADHIICDPKFAGIVAELFGNTAVVTSIADGENVSKKYACDAVTLDGDQVSRRGGITGGYIESRSLKLSAFKYEKVAAADFLRGDEALKKITQELDNVNQALTGVVTTLSSLKTEMSSITKSKDGSQVVEQHAQRKAALDRQKDKLYASKKQLEDMINTAQVNIATYQHEGKEAFKSAWSEGEQRELEALVKDVDDRRMKLSKLQRRSAQLAAEVRALEDMRLNLNVQLTATKKFFHDSAQLSASNTAITNEKENLDDDISFNSQQANEVYRLLDETRKEKLRREEEVEKLRSGYLEALNSIQERRDFDGRTLMQQAHCIRRRDGAAEKIRQLGVIPKEAETYSGLSREKLIQTLKECNKAAEKYAHINRKAVDQYNTLMETKNGLVAQKEDLQNELKSIRDLMDHLDCKKDEAVERTYKQIQLHFEQVFKELVTTDDCYGKLQLIMSNTRKEAGEDPYVAVQIKVSFGLGAAVTDLKQLSGGQKSLVALALIFAIQRCDPAPFYLFDEIDAALDTEYRASVAKLLSKESGSCQFITATFKNEMLDVADHVLGVFFHNKISRIQAITVEEGNKLLKQAVVEERKRVREHVE
InterPro domains: - IPR036277: SMCs flexible hinge superfamily (homologous_superfamily) [487-676]
- IPR010935: SMCs flexible hinge (domain) [530-643]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-1184]
- IPR003395: RecF/RecN/SMC, N-terminal (domain) [2-1168]
- IPR041741: Structural maintenance of chromosomes 3, ABC domain, eukaryotic (domain) [3-168]
- IPR024704: Structural maintenance of chromosomes protein (family) [1-1183]
Interaction partners: - DNA polymerase eta
- SCD domain-containing protein
- Structural maintenance of chromosomes protein
- Sister chromatid cohesion protein
- Double-strand-break repair protein rad21 homolog, putative
- EF-hand domain-containing protein
- Sister chromatid cohesion protein
- Uncharacterized protein
- N-acetyltransferase ESCO acetyl-transferase domain-containing protein
- Condensin subunit 1, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0000278 (mitotic cell cycle), GO:0007059 (chromosome segregation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)