Protein: Cation/calcium exchanger 2 (Protein CATION EXCHANGER 8) (Q9FKP2)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
Subcellular location: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Sequence: MGFSFSSNRFGYLTVTFLLVISCLLLGFFTNPVDSSALRPKSEHDCSALKHFHDYKSKCAYLKSIDPCASQGFFDYLSFLYCNFEGFPILGQFLLFLWLLLLFYLLGHTASEYFCSSLESLSKLLNLSPTVAGVTLLSLGNGAPDLFASLVSFMGESKGTYDVGLNTVVGGSGFVTCVVVGIISISLHKRRVRIERAAFIRDICFFCAAIGSLALILVYGKINFWGALGFCSLYAVYVAFVVLSWRFGGDQGAESDLESIHKRGSLSEPILQRDGLEEIEDGVVNGEHQIVDDDDDHQRYYYWKRLVIWAITLPLNLPRILTIPVVSEDKWSKPLAVASVTFAPVLLSFLWNWKRKPTSFEAGVVYLIGCLIGIALGFIAGATTKKLTPPKKWLLPWLAGGFVMSMTWSYISAQELVALLTSLGYIFGVSPSILGLTVLAWGNSIGDLITNLTMALHDGNEGAQVAVSGCYAGPIFNTLFALGISLVGCAWEAYPLSIVIKTDPRLLESLGFLVAGLVWSFLVLFSNRMRLGGVMGIGLLVIYLASLSLRIMQTVGDAH
InterPro domains: - IPR051359: Calcium:cation antiporter (family) [37-556]
- IPR004837: Sodium/calcium exchanger membrane region (domain) [96-551]
- IPR044880: NCX, central ion-binding domain superfamily (homologous_superfamily) [127-552]
Interaction partners: - Vacuolar cation/proton exchanger 2
- Vacuolar cation/proton exchanger 5
- P-loop containing nucleoside triphosphate hydrolases superfamily protein
- At5g19500
- Chloroplastic calcium uniporter protein
- Magnesium/proton exchanger
- ADP,ATP carrier protein
- Sodium/calcium exchanger NCL
- Putative vacuolar cation/proton exchanger 6
- Putative DNA repair protein recA homolog 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005384 (manganese ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0006950 (response to stress), GO:0001101 (response to acid chemical), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0010119 (regulation of stomatal movement), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0006970 (response to osmotic stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0098797 (plasma membrane protein complex), GO:0009651 (response to salt stress), GO:0071702 (organic substance transport), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0055074 (calcium ion homeostasis), GO:0070588 (calcium ion transmembrane transport), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0006874 (intracellular calcium ion homeostasis), GO:0006816 (calcium ion transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0034399 (nuclear periphery), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)