Protein: Aldo-keto reductase family 1 member A1-B (Q568L5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids. Acts as an aldehyde-detoxification enzyme (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S- nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S- nitrosylate proteins (By similarity). Also acts as a S-nitroso- glutathione reductase by catalyzing the NADPH-dependent reduction of S- nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity)
Subcellular location: Cytoplasm, cytosol. Apical cell membrane
Sequence: MNDFAVLSTGRKMPLLGLGTWKSEPGLVKQAVIWALESGYRHIDCAPIYANEPEIGEAFQETMGPDKGIRREDVFVTSKLWNTKHHPDDVEPSLLKTLKDLKLEYLDLYLIHWPYAFQRGDTPFPRKEDGTLLYDDIDYKLTWAAMEKLVGKGLVRAIGLSNFNSRQIDDILSVASIKPTVLQVESHPYLAQVELLSHCRDRGLVMTAYSPLGSPDRAWKHPDEPVLLEEPAIAALAKKYNKTPAQIIIRWQTQRGVVTIPKSITQSRIKENIQVFDFTLESEEMSQVTALHRGWRYIVPTITVDGKSVPRDAGHPHYPFNDPY
InterPro domains: - IPR044481: Aldo-keto reductase family 1 member A1 (family) [7-311]
- IPR023210: NADP-dependent oxidoreductase domain (domain) [16-291]
- IPR018170: Aldo/keto reductase, conserved site (conserved_site) [39-275]
- IPR020471: Aldo-keto reductase (family) [5-307]
- IPR036812: NAD(P)-dependent oxidoreductase domain superfamily (homologous_superfamily) [2-324]
Interaction partners: - Aldehyde dehydrogenase
- Beta-glucuronidase
- Glucuronokinase with putative uridyl pyrophosphorylase
- Klotho
- Monoglyceride lipase
- Aldo-keto reductase family 1 member A1-A
- Inositol oxygenase
- Aldehyde dehydrogenase
- Lactoylglutathione lyase
- Aldehyde dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0098754 (detoxification), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0051716 (cellular response to stimulus), GO:0071704 (organic substance metabolic process), GO:1990748 (cellular detoxification), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044282 (small molecule catabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0009636 (response to toxic substance), GO:0110095 (cellular detoxification of aldehyde), GO:0044249 (cellular biosynthetic process), GO:0005996 (monosaccharide metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0005975 (carbohydrate metabolic process), GO:0006766 (vitamin metabolic process), GO:1901575 (organic substance catabolic process), GO:0010033 (response to organic substance), GO:1901135 (carbohydrate derivative metabolic process), GO:0006081 (cellular aldehyde metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901334 (lactone metabolic process), GO:0016054 (organic acid catabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0097237 (cellular response to toxic substance), GO:0046185 (aldehyde catabolic process), GO:0006767 (water-soluble vitamin metabolic process), GO:0009110 (vitamin biosynthetic process), GO:0046364 (monosaccharide biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0110096 (cellular response to aldehyde), GO:0016051 (carbohydrate biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0019852 (L-ascorbic acid metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0019752 (carboxylic acid metabolic process), GO:0042364 (water-soluble vitamin biosynthetic process), GO:1901336 (lactone biosynthetic process), GO:0046395 (carboxylic acid catabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0006063 (uronic acid metabolic process), GO:0019585 (glucuronate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)