Protein: Semaphorin-3B (A0A8M1NJX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons
Subcellular location: Membrane. Secreted
Sequence: MMMMMCCTLVLFGLIGISASLSGSSQSSPRMKLSYKDLQQFNGIKRFDLERSCSFGALLLDEERGRLFVGARNFLLSLSLDNISKQEQKIYWPAPVDWREECNWAGKDINTDCVNYVKVLHHYNRTHLYACGTGAFHPTCAYVEVGQKMEDHVFRIDPSLVEDGKGKSPYDPRHTSASVLIGDELYAGVATDLMGRDFTIFRSMGQKPSIRTEQHDSRWLNEPKFIAAFGVPESDNPDDDKVFFFFRETAVEAQGFGKVTYSRIGQLCRNDMGGQRSLVNKWTTFLKARLVCSVPGNDGTETHFDELRDVFLLQTRDKKNPLIYTVFTTSSSVFQGSAVCLYTMNDIRRAFLGPFAHKEGPNYQWIPFQGKVPYPRPGMCPSKTFGSFESTKGFPDNVIQFARHHPLMFNPVTPLGGRPLFLRTGIPYTFTQITVDRVNAADGHYDVMFIGTDVGSVLKVISVPKGSWSNTELLLEELHVFKDSSSIISMQISSKRQQLYVGSDTGVVQVPLHRCSMYGKACAECCLARDPYCAWDGHTCTRYLPNTKRRFRRQDVRNGDPNALCSGDHQKQRVLEKRLYAVDGSSSFLECVPKSLQAQITWTYQKLPENPREEVRLDERVLQTERGLLLRRAVRRDAGVYQCHSMEHGFTQTILAITLEILPSAGSAPSAVNPRSPAHSHVSHGQSTNQKLWYRDFMQLVDHPNLNTVDQICEQVWSRKHSLSGKSPPDPAIEVPAHDPLNSKKWKHLKEMRKGRNRRTHDGKPASRAPRSAGE
InterPro domains: - IPR027231: Semaphorin (family) [6-767]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [579-661]
- IPR007110: Immunoglobulin-like domain (domain) [561-643]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [577-661]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [25-516]
- IPR036352: Sema domain superfamily (homologous_superfamily) [43-518]
- IPR002165: Plexin repeat (repeat) [514-543]
- IPR001627: Sema domain (domain) [30-512]
- IPR016201: PSI domain (domain) [514-566]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001763 (morphogenesis of a branching structure), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0061138 (morphogenesis of a branching epithelium), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009888 (tissue development), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0035239 (tube morphogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0001944 (vasculature development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0048666 (neuron development), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0048514 (blood vessel morphogenesis), GO:0072359 (circulatory system development), GO:0001569 (branching involved in blood vessel morphogenesis), GO:0060429 (epithelium development), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0008045 (motor neuron axon guidance), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)