Protein: Auxin transporter protein 1 (Auxin influx carrier protein 1) (Polar auxin transport inhibitor-resistant protein 1) (Q96247)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. Unloads auxin from the mature phloem to deliver the hormone to the root meristem via the protophloem cell files. Coordinated subcellular localization of AUX1 is regulated by a brefeldin A-sensitive (BFA) vesicle trafficking process. Involved in lateral root formation, trichoblast polarization and root hair elongation. Required for gravitropism and thigmotropism, especially in roots, by modulating responses to auxin, ethylene and cytokinins such as benzyladenine (BA). Needed for ammonium-mediated root-growth inhibition. Confers sensitivity to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D, auxin analog), and to polar auxin transport inhibitors such as N-1-naphthylphthalamic acid (NPA) and 2,3,5-triiodobenzoic acid (TIBA).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11641271, ECO:0000269|PubMed:11864575, ECO:0000269|PubMed:15486104}; Multi-pass membrane protein {ECO:0000269|PubMed:11641271, ECO:0000269|PubMed:11864575, ECO:0000269|PubMed:15486104}. Note=In S2 columella cells, a dynamic cytoplasmic to membrane localization seems to occur during early stage of gravity signal transduction. In roots protophloem cells, asymmetric repartition in the upper plasma membrane.
Sequence: MSEGVEAIVANDNGTDQVNGNRTGKDNEEHDGSTGSNLSNFLWHGGSVWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGIVLQIFYGLLGSWTAYLISVLYVEYRARKEKEGKSFKNHVIQWFEVLDGLLGSYWKALGLAFNCTFLLFGSVIQLIACASNIYYINDHLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIASIIHGQAEGVKHSGPTKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKYIYLMATLYVFTLTIPSAAAVYWAFGDALLDHSNAFSLMPKNAWRDAAVILMLIHQFITFGFACTPLYFVWEKVIGMHDTKSICLRALARLPVVIPIWFLAIIFPFFGPINSAVGALLVSFTVYIIPSLAHMLTYRSASARQNAAEKPPFFMPSWTAMYVLNAFVVVWVLIVGFGFGGWASVTNFVRQVDTFGLFAKCYQCKPAAAAAHAPVSALHHRL
InterPro domains: - IPR013057: Amino acid transporter, transmembrane domain (domain) [44-437]
Interaction partners: - Protein TRANSPORT INHIBITOR RESPONSE 1
- Protein TOPLESS
- Auxin response factor 19
- Toll/interleukin-1 receptor-like protein
- Auxin response factor 7
- Auxin response factor 5
- Auxin efflux carrier component 7
- Corepressor
- Auxin efflux carrier component 3
- Protein AUXIN SIGNALING F-BOX 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009607 (response to biotic stimulus), GO:0007389 (pattern specification process), GO:0003006 (developmental process involved in reproduction), GO:0051707 (response to other organism), GO:0009791 (post-embryonic development), GO:0090698 (post-embryonic plant morphogenesis), GO:0048826 (cotyledon morphogenesis), GO:0048316 (seed development), GO:0099402 (plant organ development), GO:0048598 (embryonic morphogenesis), GO:0043207 (response to external biotic stimulus), GO:1905392 (plant organ morphogenesis), GO:0003002 (regionalization), GO:0048731 (system development), GO:0010016 (shoot system morphogenesis), GO:0009790 (embryo development), GO:0048608 (reproductive structure development), GO:0009793 (embryo development ending in seed dormancy), GO:0009624 (response to nematode), GO:0048367 (shoot system development), GO:0061458 (reproductive system development), GO:0048364 (root development), GO:0010051 (xylem and phloem pattern formation), GO:0009965 (leaf morphogenesis), GO:0048825 (cotyledon development), GO:0048827 (phyllome development), GO:0010154 (fruit development), GO:0022622 (root system development), GO:0048366 (leaf development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)