wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Extracellular glycosidase CRH12 (EC 3.2.-.-) (Congo red hypersensitive protein 12) (Q5AK54)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Extracellular glycosidase which plays an important role in fungal pathogenesis. Involved in cell wall assembly and regeneration, filamentation, and adherence to host cells.
Subcellular location: Secreted, cell wall {ECO:0000269|PubMed:16455273}. Membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Covalently-linked GPI-modified cell wall protein (GPI-CWP).
Sequence: MYKQILTFLILFLRYILSEFPDDPYEDDDTSDDNNSDYEGQKCNPYRDKACLVNDEALGKKIFESFAEGTKYFTITSSTRGVRFGSEGLALTIQDEFDNPALVSSFYIMYGKVEAEIKGAAGKGIISSFYLQSDDLDEIDVVEIFGSDPYEFQTNFFIKGNTTTYDRGRYHEMHPSPLSEFHKYGIEWSPDLITWYLDDKPVRMLGRRNKHGLPCSPMFLKFSLWSVEDDDEGTIAWAGGAASFSEGPFTMHIKNLKVQDYSKALTYSYGNLRDGNWLDLRADGGYLYEGHKYCLPPKMLDKLKPTPKQETDDDQVLTSSKSQRVATTISEDKNTVSYYPPSATNSHTTWDRLSEWETEQDETGTDDTENSDNEEEESITAIPISKSRKGSTRRLDISTQLPPLSQNESKIAEIKNITTTKHIHNTTTSLQISKIKSKKVGVTTTIYSSSTPQSTSKSRMPYNIFFNYPGKENSRFKSGVSSILATSFSSVVIAEILVIVVLLL
InterPro domains: - IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [78-262]
- IPR000757: Beta-glucanase-like, N-terminal domain (domain) [18-270]
- IPR050546: Glycosyl Hydrolase Family 16 (family) [72-262]
- IPR017168: CRH-like (family) [7-504]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0030447 (filamentous growth), GO:0044403 (biological process involved in symbiotic interaction), GO:0071840 (cellular component organization or biogenesis), GO:0071554 (cell wall organization or biogenesis), GO:0071555 (cell wall organization), GO:0051701 (biological process involved in interaction with host), GO:0016043 (cellular component organization), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0071852 (fungal-type cell wall organization or biogenesis), GO:0045229 (external encapsulating structure organization), GO:0070783 (growth of unicellular organism as a thread of attached cells), GO:0031505 (fungal-type cell wall organization), GO:0044406 (adhesion of symbiont to host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0009986 (cell surface), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Biogenesis of lysosome-related organelles complex 1 subunit 1 (Protein acetyltransferase BLOC1S1) (Q1LXG2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MLSRLLKEHQAKQNERKELQERRRREAIAAATCLTEALVDHLNVGVAQAYVNQRKLDHEVKTLQVQAGQFAKQTAQWINMVENFNQALKEIGDVENWARSIEMDMRTIATALEYVHKGPVQPAST
InterPro domains: - IPR009395: Biogenesis of lysosome-related organelles complex 1 subunit 1 (family) [1-119]
Interaction partners: - Biogenesis of lysosomal organelles complex-1, subunit 2
- Biogenesis of lysosome-related organelles complex 1 subunit 6
- SNARE-associated protein Snapin
- Biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino.
- Dystrobrevin-binding protein 1b.
- Biogenesis of lysosome-related organelles complex 1 subunit 3
- Biogenesis of lysosome-related organelles complex 1 subunit 5
- Dysbindin-A
- BLOC-1-related complex subunit 8
- BLOC-1 related complex subunit 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021517 (ventral spinal cord development), GO:0021510 (spinal cord development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0021515 (cell differentiation in spinal cord), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0021953 (central nervous system neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Dynactin subunit 2 (Q7T3H1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13561}. Membrane {ECO:0000250|UniProtKB:Q13561}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13561}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0A5G2QD80}.
Sequence: MADPKYANLPGIASNEPDVYETSDLPEDDQAQFESELEELCSDSVERIVVNPNAAYDKFKDKHVSAKSLDFSDRISKNRRVGYESGDYELLAEGCGVKETPQQKYQRLVNEIHELCQDVEKIQTSTKESGAEERLTPVALAQQAAQLKQQLVSAHLDSLLGPDAHINLTDPDGALAKRLLTQLEVARGVRSGAGADGKTAAPKGPDGVILYELHSRPEQEKFTESAKVAELERRLAELETAVGSGSDKRGPLSSGVQGSSLTETLELLQARVSALDAATLDQVEARLQSVLGKMNEIAKHKATMEDAETQSKVSQLYDVVQKWDAMATSLPQVVRRLTAVRELHEQAMQFGQLLTHLDTTQQMINNSLKDNSTLLTQVQQTMKENLLAVEENFSALDQRMKKLNK
InterPro domains: - IPR028133: Dynamitin (family) [1-405]
Interaction partners: - Dynactin 3
- Dynactin 4.
- Actin-related protein 10
- Dynactin 1a.
- Dynactin 5.
- Dynactin 1b.
- F-actin-capping protein subunit beta
- Actin related protein 1, centractin
- Dynein, cytoplasmic 1, intermediate chain 2a
- Dynein light intermediate chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:1903047 (mitotic cell cycle process), GO:0000278 (mitotic cell cycle), GO:0007051 (spindle organization), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0007052 (mitotic spindle organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: WW domain-binding protein 2 (WBP-2) (Q969T9)
Organism: Homo sapiens (Human)
Function: Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity. Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21642474}. Nucleus {ECO:0000269|PubMed:21642474}. Note=Translocates from cytoplasm to nucleus when phosphorylated. {ECO:0000269|PubMed:21642474}.
Sequence: MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANYIKGTVKAEAGGGWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPSGAYGYSYMPSGAYVYPPPVANGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPDVPSTPAAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ
InterPro domains: - IPR004182: GRAM domain (domain) [36-131]
- IPR044852: WW domain-binding protein 2-like (family) [1-250]
Interaction partners: - Transcriptional coactivator YAP1
- WW domain-binding protein 1
- Cytochrome c1, heme protein, mitochondrial
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome b-c1 complex subunit 8
- Cytochrome b-c1 complex subunit 7
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- E3 ubiquitin-protein ligase NEDD4
- E3 ubiquitin-protein ligase NEDD4-like
- WW domain-containing oxidoreductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0071840 (cellular component organization or biogenesis), GO:0019068 (virion assembly), GO:0044237 (cellular metabolic process), GO:0061919 (process utilizing autophagic mechanism), GO:0019058 (viral life cycle), GO:0046755 (viral budding), GO:0009056 (catabolic process), GO:0039702 (viral budding via host ESCRT complex), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006914 (autophagy), GO:0044248 (cellular catabolic process), GO:0016236 (macroautophagy), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0016050 (vesicle organization), GO:0007032 (endosome organization), GO:0036257 (multivesicular body organization), GO:0036258 (multivesicular body assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Os05g0163900 protein (cDNA clone:002-168-H12, full insert sequence) (Q75IR0)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Not known
Sequence: MAACQQQIWQEGKQQQHLHHGGYDDLSSVYRGTVVLPRRQGGLAPEPPPPRPSSSSGRSAAAQATAMTIHSEAERRRRERINAHLATLRRILPDAKQMDKATLLASVVNQVKHLKTRATEATTPSTAATIPPEANEVTVQCYAGGEHTAAARTYVRATVSCDDRPGLLADIAATFRRLRLRPLSADMSCLGGRTRHAFVLCREEEEEEDAAAEARPLKEAVRQALAKVALPETVYGGGGRSKRQRLMMESRYSTAVVHTHVDPQYCWYNSR
InterPro domains: - IPR054502: Plant bHLH transcription factor, ACT-like domain (domain) [158-224]
- IPR002912: ACT domain (domain) [156-236]
- IPR045847: Transcription factor AIG1-like (family) [40-250]
- IPR045865: ACT-like domain (homologous_superfamily) [153-209]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [62-123]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [65-120]
Interaction partners: - Transcription factor RF2a
- Defective in exine formation protein, putative, expressed
- Os03g0830300 protein
- Os10g0112100 protein
- Os03g0830400 protein
- Os03g0101800 protein
- Os03g0830500 protein
- Os01g0267400 protein
- Os04g0461600 protein
- Os06g0266266 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: formate--tetrahydrofolate ligase (EC 6.3.4.3) (Q54G53)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Sequence: MENFNYPKLNLIKPVPSDIEIASSVEPLPIKTIAKSIGLLEEEIDFYGKYKAKVSLEVIERLKETENGNYVVVTGINPTPLGEGKSTTTIGLCQALGAHLGKKTFACIRQPSQGPTFGIKGGAAGGGYSQVIPMEEFNLHMTGDIHAITAANNLLAAAIDTRILHEGTQTDAQLWKRLCPVDSKDGSRKFAPIMLRRLKKLGIDKTDPNQLTEEEISKFVRLDIDPTRITWNRVLDTNDRFLRGISVGQGKEEQRFERKTNFDISVASEIMAVLALCTSLSDMRERLGRMVVGPSRSGEPITADDLGVGGALTVLMKDAIMPTLMQTLEGTPVLVHAGPFANIAHGNSSIIADQIALKLAGKDGYVVTEAGFGADIGAEKFFDIKCRSSGLKPNCAVIVATIRALKMHGGGPKVVAGTPLDKAYTSENIELLKKGVSNLAHHIKNLKKFGVGVVVAINKFHTDSDAEVNLLVEASLTAGANDAVMSDHWAEGGNGALDLANAVEKACKETNKDNFKYLYPLDKSIKEKIETIAKEIYGADGVEYSPEADDKIKLYTTQGFDKLPICMAKTHLSLSHDPERKGVPTGFILPIRDVRASIGAGFIYPLVGSMATIPGLPTRPCFYEIDIDTNTGKIIGLS
InterPro domains: - IPR020628: Formate-tetrahydrofolate ligase, FTHFS, conserved site (conserved_site) [118-410]
- IPR000559: Formate-tetrahydrofolate ligase, FTHFS (family) [15-638]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [16-636]
Interaction partners: - Bifunctional purine biosynthetic protein purD
- Bifunctional purine biosynthesis protein purH
- Formimidoyltransferase-cyclodeaminase
- Serine hydroxymethyltransferase 1
- Serine hydroxymethyltransferase 2
- Phosphoribosylglycinamide formyltransferase
- Methionine synthase
- dihydrofolate reductase
- methenyltetrahydrofolate cyclohydrolase
- Methenyl tetrahydrofolate cyclohydrolase / NADP-dependent methylene H4F dehydrogenase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding), GO:0008198 (ferrous iron binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0042221 (response to chemical), GO:0016043 (cellular component organization), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0043933 (protein-containing complex organization), GO:0022411 (cellular component disassembly), GO:0046688 (response to copper ion), GO:0071248 (cellular response to metal ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle)
Protein: Alpha-S1-casein (Alpha-casein) (P19228)
Organism: Mus musculus (Mouse)
Function: Important role in the capacity of milk to transport calcium phosphate.
Subcellular location: Secreted.
Sequence: MKLLILTCLVAAAFAMPRLHSRNAVSSQTQQQHSSSEEIFKQPKYLNLNQEFVNNMNRQRALLTEQNDEIKVTMDAASEEQAMASAQEDSSISSSSEESEEAIPNITEQKNIANEDMLNQCTLEQLQRQFKYNQLLQKASLAKQASLFQQPSLVQQASLFQQPSLLQQASLFQQPSMAQQASLLQQLLLAQQPSLALQVSPAQQSSLVQQAFLAQQASLAQKHHPRLSQSYYPHMEQPYRMNAYSQVQMRHPMSVVDQALAQFSVQPFPQIFQYDAFPLWAYFPQDMQYLTPKAVLNTFKPIVSKDTEKTNVW
InterPro domains: - IPR031305: Casein alpha/beta, conserved site (conserved_site) [8-15]
- IPR001588: Casein, alpha/beta (family) [215-304]
- IPR026999: Alpha-s1 casein (family) [1-312]
Interaction partners: - Beta-casein
- Alpha-S2-casein-like B
- Kappa-casein
- Alpha-lactalbumin
- Alpha-S2-casein-like A
- Whey acidic protein
- Glycosylation-dependent cell adhesion molecule 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0008083 (growth factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0051240 (positive regulation of multicellular organismal process), GO:1904018 (positive regulation of vasculature development), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:1901342 (regulation of vasculature development), GO:0045766 (positive regulation of angiogenesis), GO:0045765 (regulation of angiogenesis), GO:0007498 (mesoderm development), GO:0034505 (tooth mineralization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: LEM3 (Ligand-effect modulator 3) family / CDC50 family (Q38DJ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MSFGRLLKQQRLPAWQLNLTPRIVCVILWTIAFICIPLGIFVEFCNRNAKEASFRYDNEPTKCTEETFSLIGGQGTGKRTVCETHFEFVLAETLRQPVYFYYGLTKMYQNHRRYTNSRSGKQLMGADVRSETDANPFVIPGDTMDNTNKPIEFGGRNHTYKDFVYVPVGLVAWSMFNDTFTLFRKEKNGSNPGEVLICNGTDFSRHTNKPLHRSVSHNHCDKNGIAWESDIKKKFLEPKWDGSGPVWTAPRSEYGKPSIESNDTYFNNGWYAGEEGHMIPVVTDEDFMVWMRASPLPNVRKLYRIIRTDLRAGKYVMKIRQNYNTKPYGGEKSFIFLQPSMLGGKLTSLSITYFAVGGLALIFTVLVLFASHVWGHHSFAVVERLLTK
InterPro domains: - IPR005045: CDC50/LEM3 family (family) [4-383]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007166 (cell surface receptor signaling pathway), GO:0007224 (smoothened signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Ubiquinol-cytochrome c reductase complex assembly factor 6 (Protein BRAWNIN) (Q69YU5)
Organism: Homo sapiens (Human)
Function: Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation. Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:32161263, ECO:0000269|PubMed:34969438}; Single-pass type II membrane protein {ECO:0000305|PubMed:32161263}.
Sequence: MPAGVPMSTYLKMFAASLLAMCAGAEVVHRYYRPDLTIPEIPPKRGELKTELLGLKERKHKPQVSQQEELK
InterPro domains: - IPR027858: Protein BRAWNIN (family) [1-60]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0017004 (cytochrome complex assembly), GO:0017062 (respiratory chain complex III assembly), GO:0034551 (mitochondrial respiratory chain complex III assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Stathmin-3 (Hippocampus abundant transcript 3) (SCG10-like protein) (SCG10-related protein HiAT3) (O70166)
Organism: Mus musculus (Mouse)
Function: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.
Subcellular location: Golgi apparatus. Cell projection, growth cone. Cell projection, axon. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JHU6}.
Sequence: MASTVSAYKEKMKELSVLSLICSCFYSQPHPNTIYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPVLSSPPKRKDASLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSRLAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG
InterPro domains: - IPR030514: Stathmin, conserved site (conserved_site) [75-117]
- IPR000956: Stathmin family (family) [3-180]
- IPR036002: Stathmin superfamily (homologous_superfamily) [39-175]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0007275 (multicellular organism development), GO:0048856 (anatomical structure development), GO:0048731 (system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030427 (site of polarized growth), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0030426 (growth cone), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon)