Protein: 7-dehydrocholesterol reductase (Q7SXF1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7- DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core (By similarity). Can also metabolize cholesta-5,7,24-trien-3beta- ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol (By similarity). Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MMASDRVRKRHKGSANGAQTVEKEPSKEPAQWGRAWEVDWFSLSGVILLLCFAPFLVSFFIMACDQYQCSISHPLLDLYNGDATLFTIWNRAPSFTWAAAKIYAIWVTFQVVLYMCVPDFLHKILPGYVGGVQDGARTPAGLINKYEVNGLQCWLITHVLWVLNAQHFHWFSPTIIIDNWIPLLWCTNILGYAVSTFAFIKAYLFPTNPEDCKFTGNMFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGYVTNSMILVNVLQAVYVVDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPFLYTLQGLYLVYNPIQLSTPHAAGVLILGLVGYYIFRVTNHQKDLFRRTEGNCSIWGKKPTFIECSYQSADGAIHKSKLMTSGFWGVARHMNYTGDLMGSLAYCLACGGNHLLPYFYIIYMTILLVHRCIRDEHRCSNKYGKDWERYTAAVSYRLLPNIF
InterPro domains: - IPR018083: Sterol reductase, conserved site (conserved_site) [216-465]
- IPR001171: Sterol biosynthesis ERG24/DHCR-like (family) [63-478]
Interaction partners: - Lanosterol 14-alpha demethylase
- Ergosterol biosynthesis 28 homolog
- Cholesterol 25-hydroxylase-like protein
- 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7
- Cholesterol 7-alpha-monooxygenase
- Cytochrome P450 7A1
- O-acyltransferase
- Cholesterol 25-hydroxylase-like protein 2
- Cholesterol 25-hydroxylase-like protein 1, member 1
- Cholesterol 25-hydroxylase-like protein 1, member 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0050794 (regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048732 (gland development), GO:0072001 (renal system development), GO:0001822 (kidney development), GO:0061008 (hepaticobiliary system development), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005637 (nuclear inner membrane), GO:0005634 (nucleus)