Protein: Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Zgc:158179 protein) (A4IFW3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MSSARARFFFIIFIFIQSAAGFRVQLQDGVRMLMSLDDGDIGPGVSEYAVRVSGEPLTHTLLFQQAADAHTLPEPLLFNASYHGLLYSISLMTDGRTHTTRSIITQPLPLDSVEMWDYAPSPETAVVFQIRSPDRNIFTRVNISYTEGHQRRYMLYKDFLHGKTVFKHWLSGVCYSNITFQLISEASVNRSALLSRSDITHNPQQHRTVPNPPLNVSLKILHLSGRGPPGPVLTGAILKNSHNASVVRRERDLPEYEEQEPTSDTLNTESNLTHTQLNQSESENESESEPVTAEPTLNSSTQSLWAWQTVSPAPTEEEEEGFVNALVPEYEDSNEPGSALGIPLEPAVMPAVMPTPLAPVLLQLRWSPPAPHTAYDAFNIYIYRNGNSTETATVDENTHEFLAELSESGTYRIHVTTLSSAGDCEARESSANTAFTFYLSPSGEWMEQPQERPQAVSVKMLDSSTAAVSWAPSTHTYNGSLISVQSLTCLRPSISQRMELNYCSEENITSDIISSLTPGAQYRVVVYHTNGPLVSPASEPVIIDIEPTGVRDLVVYPLSPSAVILSWQRPYNVAFRKYVLQTFFFNSATQTAQWSTYYEIAATASVIASVRVTDLLPAWFYNFRVTMVTWGDPPLSCCDTSTVSFITAPEAPHISSVEFSHGSVFVRWTYGDLFTDLTHSRMLHWQVVAEGKKSARRRFSVDVTRSVMKASLALPAGDIYNLTVTACTERSCNTSAPHIMKLDPAPPRSLYAVNASDTSVTLIWAEEGVVDHYLITCRALGAHAEQKKVREPLVTSAHVLTVSGLQASTTYNCSVRSSSYSSSSDPVHITVSTTVREMNPSVAAISALAVLSVLLISLLVLFLLVLRKKHMELSRECGAETFVNFASFERDGKLPYNWRRSLFAFLTLLPSCLWTDYLLAFYINPWSKTALKKRKLTSPVQLSDFEAYLKDMGKDSAYKFSLQFEELKSVGLDLSHEAADLPINRPKNRYTNILPYDFSRVKLISLHNDEGSDYINANYIPGYNSPREYIATQGPLPDTRNDFWKMVLQQKVHIIVMLTQCNERRRVKCDHYWPFSDEPVAYGEISVEMLAETDSPEWTIRSFRLAYADETQDVLHFNYTSWPDHGVPTVNAIESILQFVQIVRQQVNRSKGPIVVHCSAGVGRTGTFISLDRLMQHIQEHEYVDVLGLVSDMRSHRLSMVQTEEQYVFIHQCVLLMWKKKKQQSHTSDVIYENVSKS
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [927-1222]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1134-1208]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [452-840]
- IPR003961: Fibronectin type III (domain) [346-837]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [350-842]
- IPR007110: Immunoglobulin-like domain (domain) [731-830]
- IPR042996: Receptor-type tyrosine-protein phosphatase O (family) [8-1238]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1113-1216]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1156-1166]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [959-1219]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004725 (protein tyrosine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009887 (animal organ morphogenesis), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016328 (lateral plasma membrane), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0099572 (postsynaptic specialization), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0097060 (synaptic membrane), GO:0043005 (neuron projection), GO:0099634 (postsynaptic specialization membrane), GO:0098984 (neuron to neuron synapse), GO:0098982 (GABA-ergic synapse), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0044309 (neuron spine), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane)