Protein: Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1) (Q8K0X8)
Organism: Mus musculus (Mouse)
Function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity).
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
Sequence: MEAPLVSLDEEFEDIRPSCTEEPEEKPQCLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTESLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDIEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDRVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQREQRELMKKRRKEKGLSLQSNRIEKGSQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
InterPro domains: - IPR011680: Fasciculation and elongation protein zeta, FEZ (family) [1-392]
Interaction partners: - Kinesin-1 heavy chain
- Synaptotagmin-1
- Disrupted in schizophrenia 1 homolog
- Short coiled-coil protein
- Kinesin heavy chain isoform 5A
- Protein unc-119 homolog A
- Syntabulin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0007017 (microtubule-based process), GO:0032989 (cellular component morphogenesis), GO:0050773 (regulation of dendrite development), GO:0008038 (neuron recognition), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0051649 (establishment of localization in cell), GO:0045184 (establishment of protein localization), GO:0007018 (microtubule-based movement), GO:0000902 (cell morphogenesis), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0022604 (regulation of cell morphogenesis), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0031344 (regulation of cell projection organization), GO:0032990 (cell part morphogenesis), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0099111 (microtubule-based transport), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0006886 (intracellular protein transport), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0015031 (protein transport), GO:0048813 (dendrite morphogenesis), GO:0008104 (protein localization), GO:0098840 (protein transport along microtubule), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0008088 (axo-dendritic transport), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0098930 (axonal transport), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis), GO:0010975 (regulation of neuron projection development), GO:0008090 (retrograde axonal transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0030427 (site of polarized growth), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043025 (neuronal cell body), GO:0005739 (mitochondrion), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0030424 (axon)