Protein: Histidine protein kinase NIK1 (EC 2.7.13.3) (Q5A599)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Required for hyphal formation and virulence. Plays a role in fungicides sensitivity, probably through the positive regulation of the HOG1-signaling pathway. Presumed to mediate phosphotransfer to the HOG1 MAP kinase pathway during oxidative and perhaps osmotic stress.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MNPTKKPRLSPMQPSVFEILNDPELYSQHCHSLRETLLDHFNHQATLIDTYEHELEKSKNANKAFQQALSEIGTVVISVAMGDLSKKVEIHTVENDPEILKVKITINTMMDQLQTFANEVTKVATEVANGELGGQAKNDGSVGIWRSLTDNVNIMALNLTNQVREIADVTRAVAKGDLSRKINVHAQGEILQLQRTINTMVDQLRTFAFEVSKVARDVGVLGILGGQALIENVEGIWEELTDNVNAMALNLTTQVRNIANVTTAVAKGDLSKKVTADCKGEILDLKLTINQMVDRLQNFALAVTTLSREVGTLGILGGQANVQDVEGAWKQVTENVNLMATNLTNQVRSIATVTTAVAHGDLSQKIDVHAQGEILQLKNTINKMVDSLQLFASEVSKVAQDVGINGKLGIQAQVSDVDGLWKEITSNVNTMASNLTSQVRAFAQITAAATDGDFTRFITVEASGEMDALKTKINQMVFNLRESLQRNTAAREAAELANSAKSEFLANMSHEIRTPLNGIIGMTQLSLDTELTQYQREMLSIVHNLANSLLTIIDDILDISKIEANRMTVEQIDFSLRGTVFGALKTLAVKAIEKNLDLTYQCDSSFPDNLIGDSFRLRQVILNLAGNAIKFTKEGKVSVSVKKSDKMVLDSKLLLEVCVSDTGIGIEKDKLGLIFDTFCQADGSTTRKFGGTGLGLSISKQLIHLMGGEIWVTSEYGSGSNFYFTVCVSPSNIRYTRQTEQLLPFSSHYVLFVSTEHTQEELDVLRDGIIELGLIPIIVRNIEDATLTEPVKYDIIMIDSIEIAKKLRLLSEVKYIPLVLVHHSIPQLNMRVCIDLGISSYANTPCSITDLASAIIPALESRSISQNSDESVRYKILLAEDNLVNQKLAVRILEKQGHSVEVVENGLEAYEAIKRNKYDVVLMDVQMPVMGGFEATEKIRQWEKKSNPIDSLTFRTPIIALTAHAMLGDREKSLAKGMDDYVSKPLKPKLLMQTINKCIHNINQLKELSRNSRGSDFAKKMTRNTPGSTTRQGSDEGSVEDMIGDTPRQGSVEGGGTSSRPVQRRSATEGSITTISEQIDR
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [554-731]
- IPR003660: HAMP domain (domain) [63-485]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [612-730]
- IPR001789: Signal transduction response regulator, receiver domain (domain) [874-999]
- IPR005467: Histidine kinase domain (domain) [507-730]
- IPR036097: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (homologous_superfamily) [489-566]
- IPR011006: CheY-like superfamily (homologous_superfamily) [762-1010]
- IPR004358: Signal transduction histidine kinase-related protein, C-terminal (domain) [655-727]
- IPR003661: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (domain) [498-565]
Interaction partners: - Phosphorelay intermediate protein YPD1
- MAP kinase kinase kinase
- Mitogen-activated protein kinase HOG1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140299 (small molecule sensor activity), GO:0000155 (phosphorelay sensor kinase activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0016775 (phosphotransferase activity, nitrogenous group as acceptor), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004673 (protein histidine kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0051606 (detection of stimulus), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0009581 (detection of external stimulus), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0046483 (heterocycle metabolic process), GO:0010570 (regulation of filamentous growth), GO:0075136 (response to host), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0060258 (negative regulation of filamentous growth), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045184 (establishment of protein localization), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0104004 (cellular response to environmental stimulus), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0031668 (cellular response to extracellular stimulus), GO:0009268 (response to pH), GO:0071555 (cell wall organization), GO:0044260 (cellular macromolecule metabolic process), GO:0071496 (cellular response to external stimulus), GO:0045184 (establishment of protein localization), GO:0035592 (establishment of protein localization to extracellular region), GO:0052200 (response to host defenses), GO:0031505 (fungal-type cell wall organization), GO:0071705 (nitrogen compound transport), GO:0009306 (protein secretion), GO:0071310 (cellular response to organic substance), GO:0072594 (establishment of protein localization to organelle), GO:0036176 (response to neutral pH), GO:1900445 (positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0071702 (organic substance transport), GO:0046903 (secretion), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0045229 (external encapsulating structure organization), GO:0046879 (hormone secretion), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0090304 (nucleic acid metabolic process), GO:0015031 (protein transport), GO:0034605 (cellular response to heat), GO:0006259 (DNA metabolic process), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0043936 (asexual sporulation resulting in formation of a cellular spore), GO:0031669 (cellular response to nutrient levels), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0071285 (cellular response to lithium ion), GO:0006281 (DNA repair), GO:0071396 (cellular response to lipid), GO:0071248 (cellular response to metal ion), GO:0032107 (regulation of response to nutrient levels), GO:0090605 (submerged biofilm formation), GO:0071692 (protein localization to extracellular region), GO:0052572 (response to host immune response), GO:0034660 (ncRNA metabolic process), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)