wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Hemoglobin alpha, adult chain 2 (A0A0A0MP82)
Organism: Rattus norvegicus (Rat)
Function: Involved in oxygen transport from the lung to the various peripheral tissues
Sequence: MVLSADDKTNIKNCWGKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKIGGHGGEYGEEALQRMFAAFPTTKTYFSHIDVSPGSAQVKAHGKKVADALAKAADHVEDLPGALSTLSDLHAHKLRVDPVNFKFLSHCLLVTLACHHPGDFTPAMHASLDKFLASVSTVLTSKYR
InterPro domains: - IPR050056: Hemoglobin and related oxygen transporters (family) [34-144]
- IPR012292: Globin/Protoglobin (homologous_superfamily) [14-144]
- IPR000971: Globin (domain) [7-144]
- IPR009050: Globin-like superfamily (homologous_superfamily) [35-144]
- IPR002338: Hemoglobin, alpha-type (family) [35-144]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0005102 (signaling receptor binding), GO:0001540 (amyloid-beta binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)
Protein: T-box transcription factor TBX20 (A0A0G2KAH3)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart
Subcellular location: Nucleus
Sequence: MEFTASPKPQLSSRANAFSIAALMSSGGPKEKEAAENTIKPLEQFVEKSSCAQPLGELTSLDAHAEFGGGGGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGEEDVLGEESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV
InterPro domains: - IPR036960: T-box superfamily (homologous_superfamily) [93-288]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [100-288]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [109-203]
- IPR046360: T-box transcription factor, DNA-binding domain (domain) [99-293]
- IPR001699: T-box transcription factor (family) [9-418]
Interaction partners: - Homeobox protein Nkx-2.5
- Transcription factor GATA-4
- Heart- and neural crest derivatives-expressed protein 2
- Heart- and neural crest derivatives-expressed protein 2
- Homeobox protein goosecoid
- Insulin gene enhancer protein ISL-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0009410 (response to xenobiotic stimulus), GO:0009725 (response to hormone), GO:0048513 (animal organ development), GO:0048545 (response to steroid hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0033993 (response to lipid), GO:0031960 (response to corticosteroid), GO:0051384 (response to glucocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Ceramide synthase 5 (A0A8I6AV69)
Organism: Rattus norvegicus (Rat)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus
Sequence: MATAAAEALGLLWGWLWSGRFWLPQNVSWADLEGPGDGYGYPRARHVLSVFPLAAGLFSVRMLFERFIAKPCALRIGIEDSAVYQVESNVTLEKVFTSISKYPDEKRLKGLSKQLDWDVRKIQCWFRHRRNQDKPPTLTKFCESMWRFTFYFCIFCYGVRFLWSMPWLWDTRQCWYNYPYQPLSRELYYYYLTQLAFYWSLVFSQFIDVKRKDFLMMFMHHLIAVTLISFSYINNMVRVGAIILCLHDSADSLLELANYARQERLCNTLFVIFGAAFMVTRLGIFPLWILNTTLFESWEIIGPFPSWWLFNGLLLILQMLHVIWSYLIARTAFKALVRGKVSKDDRSDVESSSEEDETTHTNNLSGSSSSNGANCMNGRMGGSHLAEEQGTCKAAGNLHFGASPRIHSCD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006643 (membrane lipid metabolic process), GO:0006672 (ceramide metabolic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006665 (sphingolipid metabolic process), GO:0046513 (ceramide biosynthetic process), GO:0030148 (sphingolipid biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: T-box transcription factor TBX20 (D3ZUF4)
Organism: Rattus norvegicus (Rat)
Function: Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart
Subcellular location: Nucleus
Sequence: MEFTASPKPQLSSRANAFSIAALMSSGGPKEKEAAENTIKPLEQFVEKSSCAQPLGELTSLDAHAEFGGGGGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERE
InterPro domains: - IPR036960: T-box superfamily (homologous_superfamily) [93-288]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [100-288]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [109-203]
- IPR046360: T-box transcription factor, DNA-binding domain (domain) [99-293]
- IPR001699: T-box transcription factor (family) [9-289]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035295 (tube development), GO:0003151 (outflow tract morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0060411 (cardiac septum morphogenesis), GO:0001568 (blood vessel development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003279 (cardiac septum development), GO:0003206 (cardiac chamber morphogenesis), GO:0003170 (heart valve development), GO:0003179 (heart valve morphogenesis), GO:0003205 (cardiac chamber development), GO:0035239 (tube morphogenesis), GO:1905314 (semi-lunar valve development), GO:0003209 (cardiac atrium morphogenesis), GO:0003007 (heart morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0003283 (atrial septum development), GO:0003148 (outflow tract septum morphogenesis), GO:0060841 (venous blood vessel development), GO:0003230 (cardiac atrium development), GO:0007507 (heart development), GO:0003176 (aortic valve development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cardiac titin adult N2BA isoform (Q5VJM6)
Organism: Rattus norvegicus (Rat)
Sequence: YKGPTELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLEMKPPDIPDSRVPIPTMPIRAVPPEEIPPAVAPSIPLLLPLPEEKKPPAKRIEVTKKGVKKDTKKVVAKPKEEAPPPPPVPEVAKKPPPPTPMIPAKPSEIIDVSSKAEEVKITTITRKKEIHKEKEAVYERKEAVYEKKVLIEPWEEPYEELETEPYTEPYEEPYYEEPDEDYEEIKVEAKKEVHEEWEEDYEEGQEYYEREEGYDEGEEEWEEIYHEREIIQVQKEVHEDLHEKKIPAKVPEKKVPPPKVPEAPKKPAPEEKTAVPVAKKKEAPPPKVPTAEKKVRKLLPEPKPQPKEEVVLKSVLRKRPEEEEPKVEPKKVEKVKKPEEPPPPPKAVEVEAPPEPKPKERKVPEPTKVPEIKPAIPLPGPEPKPKPEPEVKTMKAPPIEPAPTPIAAPVTAPVVGKKAEAKPKDEAAKPKGPIKGVAKKTPSPIEAERKKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIVLTE
InterPro domains: - IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-67]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [1-57]
- IPR013098: Immunoglobulin I-set (domain) [2-55]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Cd6 molecule (D3ZVW6)
Organism: Rattus norvegicus (Rat)
Sequence: MLQHGEWGTVCDDTWDLDDANVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSGSQRHPNLSTSEVPSRVPVTIESSVPVSVKDKDSQNLTLLIPCIVLGILLLVSLIFIVFLLLKAKGQYALPTSVNHQQLSTANPAGINNYHPVPITIAKEAPMLFIKPRVPEDSDSSSESDYEHYDFSSQPPVALTTFYNSQRHRVTEEEAQQNRFRMPPLEEGLEELHVSNIPAADPRPCVVDAPSLGSQYHTRNNSDSSTSSEEGYCNDPSSKPPPWNSQVFSEKSPLTEQPPNLELAGSQAMFSAGASADDSSSTSSGEWYQNFQPPPQHPPVEQFECPGPPDLQADSIDDDEEDYDDIGAA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0031401 (positive regulation of protein modification process), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042327 (positive regulation of phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0098857 (membrane microdomain), GO:0005886 (plasma membrane), GO:0044853 (plasma membrane raft), GO:0045121 (membrane raft), GO:0005901 (caveola)
Protein: C6 protein (Q6PFT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MGCFCDHYPWSTWSQCTKTCDSGTQSRLRDVQYDDHWFKNSCSQLCQIHDNRVCNVEACPINCQLTEFGPWSECSSCAKKSFRIRSVLRPSQFGGADCSQSLMEERACHPSKECGIEPLNCKDKFTCDTGRCIHADLQCNDQNDCGDNSDERDCGRIKSVCSNQRMYAFVPGADQIGFGFDAAAEQMRGAVLDNSFMGSNCTVEKQKRNFYRISANIERYEVKVETLEDFQPKETKSQKIDLANEPLYREAVKASQQKDSVFYRVHQVIATSTFKVKSSDLYLSDPFLQFLNSLPLEYNYALYRHIFQLFGTHYFSSGTLGGKYDLLFQFDREELKTFGLKESDSEYCLSDDDTLVTFFYNRHKQRNTCGNISMKTKYEGSMVKASERCITSVQGGRTEFAAALAWEKKGVSPQSTVYTDWIKSTIENPVVINYELLPLVNLVRGISCAVTKRRHFHRALEEYQTEFDSCKCAPCPNNARPALSGTECLCICQTGTYGSNCEKRAPDYTSVEVDGHWSCWSSWSPCDATLKKHRSRTCSNPAPQRGGKPCPGLEKQVEECTISIFQEQNVCINDDAFVTEDSSESRLPPGTSGCAKPLPPANSHLRINKRQYDYGDHEEIICFTGFELQGFQLIHCLQDGTWEKPKAQCIKKVCSKPSVPDGMTINPDRMEYKVGSDIMLVCLESGTSPSGRLSYSCGKSLIWEPSIPKDIYCKIDKPYVPDSSCKPGEINDGTKCVCMTKERCRGYREDLCVYDAGKETAIMMSLCAFHADRCHGDRLYFMNNGPCKSDARSLDWAKFRVSVSEQSSVQEPCGSDTCYEWETCSVSKTCECKMPRECPKDGKKIYCLKIVRTQTTRSMNLCFMAAMKCSSIEFELQHEGPCAGS
InterPro domains: - IPR002172: Low-density lipoprotein (LDL) receptor class A repeat (repeat) [120-156]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [3-565]
- IPR003884: Factor I / membrane attack complex (domain) [724-884]
- IPR001862: Membrane attack complex component/perforin/complement C9 (family) [82-492]
- IPR036055: LDL receptor-like superfamily (homologous_superfamily) [120-158]
- IPR035976: Sushi/SCR/CCP superfamily (homologous_superfamily) [594-657]
- IPR048831: Complement components C8A/B/C6, EGF-like domain (domain) [475-503]
- IPR020863: Membrane attack complex component/perforin domain, conserved site (conserved_site) [303-314]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [3-563]
- IPR023415: Low-density lipoprotein (LDL) receptor class A, conserved site (conserved_site) [132-154]
- IPR000436: Sushi/SCR/CCP domain (domain) [592-715]
- IPR020864: Membrane attack complex component/perforin (MACPF) domain (domain) [146-471]
- IPR048828: Complement component C6, KAZAL domain (domain) [737-788]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium)
Protein: Serine/threonine-protein kinase receptor (B0EXP7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Cell surface. Membrane raft. Membrane; Single-pass type I membrane protein
Sequence: MKMMMKMMMMEAVPCRLVFLAVFFGSRVQQTEGLQCYCHRCPNHTCTTDGLCYVSITRAGSLTTQQSWCIGKGELVPPDRPFVCAPSTKDDSGIYPLCCDTDWCNKDPDIKAFPVPTQKPPALGPVAFAALIAGPVCVLCFLMVTVFYICHSRSVIHHRVPSEEDPSLDHPFITVGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIASRCSIGGIHEDYQLPYHDLVQSDPSVEEMRRVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
InterPro domains: - IPR045860: Snake toxin-like superfamily (homologous_superfamily) [32-107]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [331-343]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [182-494]
- IPR017441: Protein kinase, ATP binding site (binding_site) [213-234]
- IPR003605: GS domain (domain) [177-207]
- IPR000472: Activin types I and II receptor domain (domain) [34-107]
- IPR000719: Protein kinase domain (domain) [207-497]
- IPR000333: Ser/Thr protein kinase, TGFB receptor (family) [26-500]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0045165 (cell fate commitment), GO:0001704 (formation of primary germ layer), GO:0001709 (cell fate determination), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0030154 (cell differentiation), GO:0009790 (embryo development), GO:0042246 (tissue regeneration), GO:0031099 (regeneration), GO:0007492 (endoderm development), GO:0001706 (endoderm formation), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0048332 (mesoderm morphogenesis), GO:0009953 (dorsal/ventral pattern formation), GO:0007498 (mesoderm development), GO:0060795 (cell fate commitment involved in formation of primary germ layer), GO:0035987 (endodermal cell differentiation), GO:0031101 (fin regeneration), GO:0001711 (endodermal cell fate commitment)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Frizzled-4 (A0A0R4IVK2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MARFEFGFALLVLVFGLAHPFGDEEEMTCDPIRISMCQDLGYNVTKMPNLVGNVLQSDAELQLTTFTPLIQYGCSSQLKFFLCSVYVPMCTEKVPIPIGPCGSMCMSVKRKCLPVLQEFGFVWPELLNCSLFPPTNDQNHMCMEGPGDEDPPFHAVRPVAPQEEECIALGAGVEQYAWVKRSGSCSLQCGYDTGLYRRQAKVFTDVWMAVWAVLCFISTTFTVLTFLVDSSRFSYPERPIIFLSMCCNIYSVAFIVRLTVGRERISCDLEEAAVPVLVQEGLKNTGCAIVFLLTYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADDLAGMCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWADFRQTARDSYMAAEMLRIFMSLLVGITSGMWVWSAKTLHTWQRCSHRLVHTGRNNRVKRTANGWVKPGKGNETVV
InterPro domains: - IPR036790: Frizzled cysteine-rich domain superfamily (homologous_superfamily) [19-144]
- IPR041765: Frizzled 4, cysteine-rich domain (domain) [26-150]
- IPR026551: Frizzled-4, 7TM (domain) [194-493]
- IPR000539: Frizzled/Smoothened, 7TM (domain) [194-499]
- IPR015526: Frizzled/secreted frizzled-related protein (family) [21-491]
- IPR020067: Frizzled domain (domain) [24-147]
- IPR017981: GPCR, family 2-like, 7TM (domain) [204-488]
Interaction partners: - Low density lipoprotein receptor-related protein 5
- Tetraspanin
- Tyrosine-protein kinase RYK
- Protein Wnt-5b
- Protein Wnt-1
- Protein Wnt-11
- E3 ubiquitin-protein ligase znrf3
- Protein Wnt
- Protein Wnt
- Protein Wnt-4a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0008283 (cell population proliferation), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0035988 (chondrocyte proliferation), GO:0016477 (cell migration), GO:0048882 (lateral line development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0001667 (ameboidal-type cell migration), GO:0060026 (convergent extension), GO:0048925 (lateral line system development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0042074 (cell migration involved in gastrulation), GO:0048884 (neuromast development), GO:0090504 (epiboly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Pentraxin family member (A3KPH6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MLGFIFTLLILTPAAAEVGLGGKVLLFQTQTATSYVKLTPDKPLSLSAFTLCMRVATELLGERSVILFAYRTSEVDELNVWRRKNGSVGLFIQTSSNPASFYLPPLSTFQTHLCVSWESATGLTAFWVDGRRSLYQIYKKDASVRPGGTVLLGQDPDSYVGSFDANQCFIGEITDVKLWDYVLSEIQIKALYSNQDPLVPAGNVFDWDTVKYDVVGNVTVANDNH
InterPro domains: - IPR001759: Pentraxin domain (domain) [17-225]
- IPR030476: Pentaxin, conserved site (conserved_site) [112-119]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [19-222]
- IPR051005: Pentraxin domain-containing protein (family) [6-222]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)