Protein: Sodium- and chloride-dependent betaine transporter (Betaine transporter SNF-3) (Na(+)/Cl(-) betaine/GABA transporter) (Sodium:neurotransmitter symporter family protein 3) (G5EBN9)
Organism: Caenorhabditis elegans
Function: Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space. Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24212673}; Multi-pass membrane protein {ECO:0000305|PubMed:24212673}.
Sequence: MGTSEHVPLPTDEAKAKELEQSQHSEEPDRGQWTGKFDFLMSMVAYAVGLGNVWRFPYLCYKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQKGAMEMWLMCPLFRGVGIGNVVIAFMCIAYFCVIVAWAMFYMISSIAWVFPWETCNNYWNDATCVTGKENFTELARIKALVASAGGHTQTSVEQFWEKRVLHDTGDISEFGGIQWELFFIMAAAWLIVYFALWKGITQARKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGTQVFYSYGVGFGALIALGSHNKFNHNCFKDAITMCFINGCTSITAGFAVFSILGYMSHVAQKDISEIVKPGVGLAFLAYPEVASNLPMKQVFAVLFFLMITILGLDSQVCMMEGLFTALEDAFPILRKYKKQSLGIFCLFFFCIGIPMVTHSGSHWLTLFDAYGASGYALLFVVFFEVVGLAYGFGAHNIRKALHEMIGVTLPKGIEYVWKFCAPATSLVLFVFCVVYYHPVKYPDGKDFPFWANAFGWFLSSCSMVVIPGYAIYYLFFTNKHLTLKERVRKGLNLDGSFESPAKKNLVNNAEELKFIESSSQ
InterPro domains: - IPR000175: Sodium:neurotransmitter symporter (family) [13-566]
- IPR037272: Sodium:neurotransmitter symporter superfamily (homologous_superfamily) [30-554]
Interaction partners: - Hcy-binding domain-containing protein
- Betaine receptor acr-23
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0005343 (organic acid:sodium symporter activity), GO:0140161 (monocarboxylate:sodium symporter activity), GO:0015355 (secondary active monocarboxylate transmembrane transporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005283 (amino acid:sodium symporter activity), GO:0015296 (monoatomic anion:monoatomic cation symporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015370 (solute:sodium symporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015377 (chloride:monoatomic cation symporter activity), GO:0015378 (sodium:chloride symporter activity), GO:0015185 (gamma-aminobutyric acid transmembrane transporter activity), GO:0015373 (monoatomic anion:sodium symporter activity), GO:0005416 (amino acid:monoatomic cation symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0040017 (positive regulation of locomotion), GO:0040012 (regulation of locomotion), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015695 (organic cation transport), GO:0015697 (quaternary ammonium group transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0044304 (main axon), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0044298 (cell body membrane), GO:0036477 (somatodendritic compartment), GO:0030673 (axolemma), GO:0120025 (plasma membrane bounded cell projection), GO:0045202 (synapse), GO:0032589 (neuron projection membrane), GO:0032809 (neuronal cell body membrane), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0098590 (plasma membrane region), GO:0097447 (dendritic tree), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0031253 (cell projection membrane), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0032590 (dendrite membrane), GO:0030424 (axon)