Protein: Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) (P50897)
Organism: Homo sapiens (Human)
Function: Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
Subcellular location: Lysosome {ECO:0000269|PubMed:19941651}. Secreted {ECO:0000250|UniProtKB:P45478}.
Sequence: MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLSMGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALAKDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLPRCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSIFLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSGQAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAHIIPFLG
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [21-306]
- IPR002472: Palmitoyl protein thioesterase (family) [26-300]
Interaction partners: - Battenin
- Bis
- Ceroid-lipofuscinosis neuronal protein 6
- Protein CLN8
- Tripeptidyl-peptidase 1
- Lysosomal thioesterase PPT2
- Enoyl-[acyl-carrier-protein] reductase, mitochondrial
- DnaJ homolog subfamily C member 5
- Major facilitator superfamily domain-containing protein 8
- BTB/POZ domain-containing protein KCTD7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0098599 (palmitoyl hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008474 (palmitoyl-(protein) hydrolase activity), GO:0016790 (thiolester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0009057 (macromolecule catabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0043412 (macromolecule modification), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901565 (organonitrogen compound catabolic process), GO:0042157 (lipoprotein metabolic process), GO:0006996 (organelle organization), GO:0030163 (protein catabolic process), GO:0007010 (cytoskeleton organization), GO:0098732 (macromolecule deacylation), GO:0042159 (lipoprotein catabolic process), GO:0035601 (protein deacylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)