Protein: Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (E7CU85)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Chromosome, centromere, kinetochore {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle {ECO:0000256|ARBA:ARBA00004186}. Midbody {ECO:0000256|ARBA:ARBA00004214}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
InterPro domains: - IPR001370: BIR repeat (repeat) [13-89]
- IPR051190: Baculoviral IAP repeat-containing (family) [6-140]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0043028 (cysteine-type endopeptidase regulator activity involved in apoptotic process), GO:0051087 (chaperone binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0061134 (peptidase regulator activity), GO:0019899 (enzyme binding), GO:0004857 (enzyme inhibitor activity), GO:0008092 (cytoskeletal protein binding), GO:0046872 (metal ion binding), GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process), GO:0042803 (protein homodimerization activity), GO:0061135 (endopeptidase regulator activity), GO:0051020 (GTPase binding), GO:0030414 (peptidase inhibitor activity), GO:0046982 (protein heterodimerization activity), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding), GO:0031267 (small GTPase binding), GO:0046914 (transition metal ion binding), GO:0004866 (endopeptidase inhibitor activity), GO:0008270 (zinc ion binding), GO:0004869 (cysteine-type endopeptidase inhibitor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0031503 (protein-containing complex localization), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0051301 (cell division), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0051640 (organelle localization), GO:0019222 (regulation of metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044237 (cellular metabolic process), GO:0065009 (regulation of molecular function), GO:0044238 (primary metabolic process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0000910 (cytokinesis), GO:0090068 (positive regulation of cell cycle process), GO:0051129 (negative regulation of cellular component organization), GO:0060548 (negative regulation of cell death), GO:0060255 (regulation of macromolecule metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0045787 (positive regulation of cell cycle), GO:0006793 (phosphorus metabolic process), GO:0051726 (regulation of cell cycle), GO:0051656 (establishment of organelle localization), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045786 (negative regulation of cell cycle), GO:0051128 (regulation of cellular component organization), GO:0010564 (regulation of cell cycle process), GO:0008284 (positive regulation of cell population proliferation), GO:0050790 (regulation of catalytic activity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1903047 (mitotic cell cycle process), GO:0035556 (intracellular signal transduction), GO:0044092 (negative regulation of molecular function), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0050000 (chromosome localization), GO:0009889 (regulation of biosynthetic process), GO:0044770 (cell cycle phase transition), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:0000278 (mitotic cell cycle), GO:0007346 (regulation of mitotic cell cycle), GO:0007088 (regulation of mitotic nuclear division), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0043069 (negative regulation of programmed cell death), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0007093 (mitotic cell cycle checkpoint signaling), GO:0010468 (regulation of gene expression), GO:0051983 (regulation of chromosome segregation), GO:0043412 (macromolecule modification), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0044839 (cell cycle G2/M phase transition), GO:0045930 (negative regulation of mitotic cell cycle), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0000075 (cell cycle checkpoint signaling), GO:1901989 (positive regulation of cell cycle phase transition), GO:0045839 (negative regulation of mitotic nuclear division), GO:0051336 (regulation of hydrolase activity), GO:0051248 (negative regulation of protein metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1905818 (regulation of chromosome separation), GO:0045931 (positive regulation of mitotic cell cycle), GO:0051303 (establishment of chromosome localization), GO:0007600 (sensory perception), GO:0036211 (protein modification process), GO:0044772 (mitotic cell cycle phase transition), GO:0010639 (negative regulation of organelle organization), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:1905819 (negative regulation of chromosome separation), GO:0033043 (regulation of organelle organization), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0051985 (negative regulation of chromosome segregation), GO:0051253 (negative regulation of RNA metabolic process), GO:0000281 (mitotic cytokinesis), GO:1901988 (negative regulation of cell cycle phase transition), GO:0042981 (regulation of apoptotic process), GO:0010965 (regulation of mitotic sister chromatid separation), GO:0051346 (negative regulation of hydrolase activity), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:2001141 (regulation of RNA biosynthetic process), GO:0016310 (phosphorylation), GO:1902099 (regulation of metaphase/anaphase transition of cell cycle), GO:0031577 (spindle checkpoint signaling), GO:0045841 (negative regulation of mitotic metaphase/anaphase transition), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1902100 (negative regulation of metaphase/anaphase transition of cell cycle), GO:1902679 (negative regulation of RNA biosynthetic process), GO:2001251 (negative regulation of chromosome organization), GO:0033044 (regulation of chromosome organization), GO:0051783 (regulation of nuclear division), GO:0051784 (negative regulation of nuclear division), GO:0000086 (G2/M transition of mitotic cell cycle), GO:0033045 (regulation of sister chromatid segregation), GO:1901991 (negative regulation of mitotic cell cycle phase transition), GO:0043066 (negative regulation of apoptotic process), GO:2000816 (negative regulation of mitotic sister chromatid separation), GO:0033046 (negative regulation of sister chromatid segregation), GO:0006468 (protein phosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0033048 (negative regulation of mitotic sister chromatid segregation), GO:0033047 (regulation of mitotic sister chromatid segregation), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:0045861 (negative regulation of proteolysis), GO:0050954 (sensory perception of mechanical stimulus), GO:0071174 (mitotic spindle checkpoint signaling), GO:0052548 (regulation of endopeptidase activity), GO:0010466 (negative regulation of peptidase activity), GO:0045892 (negative regulation of DNA-templated transcription), GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:0007605 (sensory perception of sound), GO:0030071 (regulation of mitotic metaphase/anaphase transition), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0007096 (regulation of exit from mitosis), GO:0007094 (mitotic spindle assembly checkpoint signaling), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0071173 (spindle assembly checkpoint signaling), GO:0031536 (positive regulation of exit from mitosis), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0010951 (negative regulation of endopeptidase activity), GO:0043281 (regulation of cysteine-type endopeptidase activity involved in apoptotic process), GO:2000117 (negative regulation of cysteine-type endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005875 (microtubule associated complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0030496 (midbody), GO:0098687 (chromosomal region), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0099080 (supramolecular complex), GO:0005814 (centriole), GO:0005881 (cytoplasmic microtubule), GO:0043229 (intracellular organelle), GO:0032133 (chromosome passenger complex), GO:0000776 (kinetochore), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0070013 (intracellular organelle lumen), GO:0099513 (polymeric cytoskeletal fiber), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005819 (spindle), GO:0005694 (chromosome), GO:0000228 (nuclear chromosome), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0000793 (condensed chromosome), GO:0005876 (spindle microtubule)