Protein: Mitochondrial inner membrane protease subunit 2 (EC 3.4.21.-) (IMP2-like protein) (Q96T52)
Organism: Homo sapiens (Human)
Function: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:15814844}; Single-pass membrane protein {ECO:0000305|PubMed:15814844}.
Sequence: MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVSPKNPEQKIIKRVIALEGDIVRTIGHKNRYVKVPRGHIWVEGDHHGHSFDSNSFGPVSLGLLHAHATHILWPPERWQKLESVLPPERLPVQREEE
InterPro domains: - IPR000223: Peptidase S26A, signal peptidase I (family) [19-132]
- IPR019758: Peptidase S26A, signal peptidase I, conserved site (conserved_site) [118-131]
- IPR036286: LexA/Signal peptidase-like superfamily (homologous_superfamily) [35-159]
- IPR019533: Peptidase S26 (domain) [15-151]
- IPR037730: Mitochondrial inner membrane protease subunit 2 (family) [5-169]
Interaction partners: - SLIT and NTRK-like protein 1
- Contactin-associated protein-like 2
- Diablo IAP-binding mitochondrial protein
- Mitochondrial inner membrane protease subunit 1
- KICSTOR complex protein ITFG2
- Histidine decarboxylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:1901564 (organonitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0006839 (mitochondrial transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0006508 (proteolysis), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0051604 (protein maturation), GO:0071702 (organic substance transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0006626 (protein targeting to mitochondrion), GO:0016485 (protein processing), GO:0070585 (protein localization to mitochondrion), GO:0034982 (mitochondrial protein processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0031975 (envelope), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)