wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: GCN5-related N-acetyltransferase 5, chloroplastic (Q9LR91)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA), with a large spectrum of modified N- termini, including methionine, alanine, serine and to a lower extent threonine and valine as substrates, and epsilon-lysine acetylation (KA)
Subcellular location: Plastid, chloroplast
Sequence: MAALSISLAFSVDSLKPTQSTKFGFSSSSHRYPLLYSCKSHRSNLRFAFPPSSVSTATETGEENSKSTGNYAFLEESFRTGRFLSNDELEKLKTLEGFAYFQELESGSMWVRVMRHEEMDSTVHLLAESFGESMLLPSGYQSVLRFLIKQYLIERREVLPHAVTLVGFFRKKVDEFSDDGEEEAVMAGTVEVCLEKRGANASPPSPTPPKESPYICNMTVKEDLRRRGIGWHLLKASEELISQISPSKDVYLHCRMVDEAPFNMYKKAGYEVVKTDTVLVLLMLQRRKHLMRKKLLPLCTNPIVEMVGSDNELTSSANV
InterPro domains: - IPR000182: GNAT domain (domain) [206-270]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [109-294]
Interaction partners: - GCN5-related N-acetyltransferase 7, chloroplastic
- GCN5-related N-acetyltransferase 10, chloroplastic
- GCN5-related N-acetyltransferase 8
- GCN5-related N-acetyltransferase 4, chloroplastic
- Acyl-CoA N-acyltransferases (NAT) superfamily protein
- GCN5-related N-acetyltransferase 1, chloroplastic
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 6, chloroplastic
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0010467 (gene expression), GO:0031365 (N-terminal protein amino acid modification), GO:0006474 (N-terminal protein amino acid acetylation), GO:0043543 (protein acylation), GO:0006473 (protein acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: GCN5-related N-acetyltransferase 7, chloroplastic (Q94AC8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA), with a large spectrum of modified N- termini, including methionine, alanine, serine, threonine and to a lower extent valine and proline as substrates, and epsilon-lysine acetylation (KA)
Subcellular location: Plastid, chloroplast
Sequence: MAFLCSSLPSSSSIAIFGDPNTDGSSRSYLSIPSLKLRFRPVAASSHICAPAIDKSTFVISESVSEDELWAAACLRVRTFNELNPSAYNIQDHRRYLAEREFEALKERTSGKREGFTRVACINATLPLSQLSSSFEDLCSACKFSDGIEDRVVVGSLDLNQCRWLPDEIAGTKPEGIGVDFARAYLSNVCVAKELHRNGVGYKLIDKSKRVAGEWGITDMYVHVTVDNEAAKSLYMKSGFEQETAEPAWQARYLNRPQRLLLWLALPTSPIMSM
InterPro domains: - IPR000182: GNAT domain (domain) [75-267]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [84-245]
Interaction partners: - GCN5-related N-acetyltransferase 10, chloroplastic
- Acyl-CoA N-acyltransferases (NAT) superfamily protein
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 8
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 1, chloroplastic
- GCN5-related N-acetyltransferase 2, chloroplastic
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0010467 (gene expression), GO:0031365 (N-terminal protein amino acid modification), GO:0006474 (N-terminal protein amino acid acetylation), GO:0043543 (protein acylation), GO:0006473 (protein acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: GCN5-related N-acetyltransferase 10, chloroplastic (Q9C7G6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Protein acetyltransferase with dual specificity triggering both N-alpha-acetylation (NTA), with a preference for leucine, methionine, serine, valine and to a lower extent threonine and alanine as substrates (can also use glycine), and epsilon-lysine acetylation (KA) of several plastid proteins
Subcellular location: Plastid, chloroplast
Sequence: MGHLPQSLYSAAGPKFPYPGSSGLGVDQRKLTWSRFPVFLRCASTESLTSLTQNNAAEIELKYLVSQHGWDVRRLNRDDEDEIRRVSLVQAEAFHIPLALFDDFFFMFFQAEVLSALLYKLKNSPPDRYACLVAEQTSETETLSSSSVVGVVDVTAQTESSVLRYFPGVEEYLYVSGLAVSKSQRRKKMASTLLKACDVLCYLWGFKLLALRAYEDDAAARNLYSNAGYSVVETDPLWTSTWIGRKRRVLMSKRFS
InterPro domains: - IPR000182: GNAT domain (domain) [106-256]
- IPR051556: N-terminal and lysine N-acetyltransferase (family) [75-255]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [72-254]
Interaction partners: - Acyl-CoA N-acyltransferases (NAT) superfamily protein
- GCN5-related N-acetyltransferase 7, chloroplastic
- GCN5-related N-acetyltransferase 1, chloroplastic
- GCN5-related N-acetyltransferase 4, chloroplastic
- GCN5-related N-acetyltransferase 5, chloroplastic
- GCN5-related N-acetyltransferase 9
- GCN5-related N-acetyltransferase 8
- N-terminal acetyltransferase B complex catalytic subunit NAA20
- GCN5-related N-acetyltransferase 2, chloroplastic
- N-terminal acetyltransferase A complex catalytic subunit NAA10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0016410 (N-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0008080 (N-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0010467 (gene expression), GO:0031365 (N-terminal protein amino acid modification), GO:0006474 (N-terminal protein amino acid acetylation), GO:0043543 (protein acylation), GO:0006473 (protein acetylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Golgin-84 (Q8SZ63)
Organism: Drosophila melanogaster (Fruit fly)
Function: May be involved in maintaining Golgi structure and in intra- Golgi transport
Subcellular location: Golgi apparatus membrane; Single- pass type IV membrane protein
Sequence: MSSWITGLADKAENILNKLDQNAATALQTENATGSADPMRRSMTSSTQSLSTSLKSTLSPVRRSGANSSSSVKSDGGVSVVTKDMRQKMTTSASFSNSPDISANSMDTNELAAFKIALNEITAERDELRLRLEDLNNETEKFDLHQHTQVLEALVKSLSEERDKAVHDYNEAQAANMAYVHSISELETNLAKLQQEYISAAHKLQMQTKETEQQRQELQEYRIKAQRALQAKDSLIAELKAKPTEEGADPNLVSKDSETRFLQIEHESLKQELEHANEELQKARLQLDDYVSQERQRQVELSSARQREETLAKELRQAREHSVTSESDQRVLTQELASLRQQLSNQMAAAATRLQEREQQLQQMRQRLSEEANTGAKSDYETRLKALTQSLVERQSLLERVTSERNALRLQHEKAQTQLQQNMHLVEMESQRGSSRHTMLNSTDDVKAQFPLLMHPSPFDNRVARRFKRALRQADSMGIRVGTFLRRYPMMRVSVIVYVALLHLWVMFVLLSTTPN
InterPro domains: - IPR019177: Golgin subfamily A member 5 (family) [211-515]
Interaction partners: - Golgi microtubule-associated protein, isoform D
- Grasp65
- Conserved oligomeric Golgi complex subunit 7
- GH05665p
- Golgi matrix protein 130 kD
- Conserved oligomeric Golgi complex subunit 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0051020 (GTPase binding), GO:0031267 (small GTPase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006810 (transport), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0016192 (vesicle-mediated transport), GO:0007030 (Golgi organization), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0000139 (Golgi membrane), GO:0000138 (Golgi trans cisterna), GO:0097708 (intracellular vesicle)
Protein: Grifin (Q6DGJ1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Binds lactose
Sequence: MTLRFEASCPDGLCPGWSVILKGETPPEASKFEINFLCDRDDRVAFHFNPRFTESDIICNSYMANRWGQEERCNHFPLGVEEPFQIEIYSDNDHFHVYIDKAKVMQYKHRVEDLKTITKLQVVNDVKISSLEITKKLFY
InterPro domains: - IPR001079: Galectin, carbohydrate recognition domain (domain) [3-134]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [3-134]
- IPR044156: Galectin-like (family) [4-133]
Interaction partners: - WD repeat domain 17
- Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
- Ankyrin repeat domain 33Ab
- Histone H1
- Histone H1
- Histone H1
- Histone H1
- Histone H1
- Histone H1
- Histone H1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030246 (carbohydrate binding), GO:0070492 (oligosaccharide binding), GO:0048030 (disaccharide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0035239 (tube morphogenesis), GO:0048514 (blood vessel morphogenesis), GO:0002064 (epithelial cell development), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0060429 (epithelium development), GO:0002040 (sprouting angiogenesis), GO:0030855 (epithelial cell differentiation), GO:0045446 (endothelial cell differentiation), GO:0001885 (endothelial cell development), GO:0003158 (endothelium development), GO:0061028 (establishment of endothelial barrier)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)
Protein: Histone H2A.V (Q71PD7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)
Subcellular location: Nucleus. Chromosome
Sequence: MAGGKAGKDSGKAKAKAVSRSQRAGLQFPVGRIHRHLKTRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTA
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [3-128]
- IPR002119: Histone H2A (family) [5-125]
- IPR032454: Histone H2A, C-terminal domain (domain) [95-127]
- IPR007125: Core Histone H2A/H2B/H3 domain (domain) [10-93]
- IPR032458: Histone H2A conserved site (conserved_site) [24-30]
Interaction partners: - Histone H2B 3
- RuvB-like 1
- Helicase SRCAP isoform X2
- Peptidyl-prolyl cis-trans isomerase
- AT-rich interactive domain-containing protein 4A
- AT-rich interactive domain-containing protein 4B
- Histone H3.3
- Histone H2A
- YEATS domain-containing protein 4
- RuvB-like 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0006306 (DNA methylation), GO:0006304 (DNA modification), GO:0006305 (DNA alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Histone H2AX (Q54WG6)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Phosphorylation of H2AX seems to be performed by atr1 and/or possibly dnapkcs, as ATM ortholog is absent in the genome of this organism
Subcellular location: Nucleus. Chromosome
Sequence: MSETKPASSKPAAAAKPKKVIPRVSRTGEPKSKPESRSARAGITFPVSRVDRLLREGRFAPRVESTAPVYLAAVLEYLVFEILELAHNTCSISKKTRITPQHINWAVGNDLELNSLFQHVTIAYGGVLPTPQQSTGEKKKKPSKKAAEGSSQIY
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [22-148]
- IPR002119: Histone H2A (family) [22-142]
- IPR007125: Core Histone H2A/H2B/H3 domain (domain) [31-107]
- IPR032454: Histone H2A, C-terminal domain (domain) [112-145]
Interaction partners: - Histone H2B.v3
- Histone H4
- Histone H2A.z
- PWWP domain-containing protein
- Histone H3.3 type c
- Histone H3.3 type a
- ATP-dependent DNA helicase ku70
- Histone H3.3 type b
- Suppressor of Mek1
- Histone H1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization), GO:0006338 (chromatin remodeling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0000793 (condensed chromosome)
Protein: Histone H4 (Q76NW2)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
Subcellular location: Nucleus. Chromosome
Sequence: MSSAQSRGGKTGGKVGGKVGAKRHKKTQKEHINGITKPAIRRLARRGGVKRISFPIYEETRNVLRTFLTNVIRDSVAYTEHAGRRTVTAMDVVYALKRQGRTLYGFNS
InterPro domains: - IPR035425: CENP-T/Histone H4, histone fold (domain) [40-101]
- IPR001951: Histone H4 (family) [6-107]
- IPR009072: Histone-fold (homologous_superfamily) [6-108]
- IPR019809: Histone H4, conserved site (conserved_site) [20-24]
Interaction partners: - Histone H2B.v3
- Probable histone-binding protein rbbD
- Histone H3.3 type c
- Histone H3.3 type a
- Histone H3.3 type b
- Histone chaperone asf1
- PWWP domain-containing protein
- Histone H2A.z
- Histone acetyltransferase type B catalytic subunit DDB_G0274269
- Protein arginine N-methyltransferase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0042221 (response to chemical), GO:0016043 (cellular component organization), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0006325 (chromatin organization), GO:0046689 (response to mercury ion), GO:0006338 (chromatin remodeling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: HUWE1-associated protein modifying stress responses 2 (A0A7P0TBJ1)
Organism: Homo sapiens (Human)
Function: Together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding. Regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1
Subcellular location: Nucleus
Sequence: MEEQQKEGEAEVAEHWFSKWERQCLAEAEQEEQLPPELQEEAAAELAGLKSEKQKLWHLFQISATAVAQLYKDSGCQQQGLSMWDPFQNAAMAVTSLYKESGDAHQRSFDLGVQVGHQRRIKDVLEWVKKGRSTIRREDLISFLCGKVPPAPPPPRTPRTPPKPPTGVTSQAVATESSSSVDVDLQPFQEAIALHGLSGAMAGISMRSGDSPQDSGVASSGRRKTSFLEDDLNPFDSEELALHLDSGGIRKRTSAQCSDGITDSPIQKRNRMV
InterPro domains: - IPR029196: HUWE1-associated protein modifying stress responses-like (family) [21-271]
- IPR040308: HUWE1-associated protein modifying stress responses (family) [1-273]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0080134 (regulation of response to stress), GO:0080135 (regulation of cellular response to stress), GO:0009966 (regulation of signal transduction), GO:1902532 (negative regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:1901796 (regulation of signal transduction by p53 class mediator), GO:1901797 (negative regulation of signal transduction by p53 class mediator)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)