Protein: Stabilin 2 (F6P8Y7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MPFLLDVVCGGLILLLGTEILWVAGAQKRCDKDITMVTKSKCHSCSLSHLAKCPNGYAKMPPGTSDRDCRYYVTPVFSISGCSFNCFKEVVEPQCCRGYWGNDCMECPGSASTPCSNNGVCSDGIAGNGTCTCASGFTGAACEECKTDLYGPTCSNVCRCKNGLCSSGLKGTGECTCFSGYTGLDCAQELPACAALQCGPDSRCIEEMLTGQLVCKCKPGYQGDGVQCTSINPCLRSVCHANAVCAHTGPNKHVCTCTEGYSGDGRVCMPIDPCQTNLGNCTSGSTRCVYDGPGKAHCECLEGFEKFVEGQGCSIIDLCKPDSCHKYATCATAEPGTVECNCREGFIGNGKICFGDIIQQLNEMNSKPGGKWTGQLSSAITLFNQVTGWFLTARGPFTVFVPVNKAFKGTSVKSLLADEMKARYLAKLHVVAGEVNSESLKKGILFHTLTGMGAESMIDAEQVKIRLHGSRKKGALVESDIFASNGMIHLIDKLMDAVPSTVISEKEESLLEILSKNGKFSQFKSLLEKTNLATVLEEDGPYTLFAPTNVAFALMKPDYLAYLKSEEGKTKLLELMRNHIVSTTPLSAYVIVSNPRAVTMAEQILTFNVTTAGQILVNGESVIELDVEAKNGRLHSLEGLLIPPSIEPILPHRCDIIKPIKYMAPCVSCTLISKSTCPTGESLKAYRRGCVFNKKQLGLSLPSIGCSHICNDTKTTPQCCKGFFGPDCSPCPGGFTTPCSSHGTCSEGIDGNGTCQCEPKFKGSRCQYCADSNKYGPNCDKTCWCIHGTCDNHPEASGKCKQGSCKDGYTGEYCELQTQPCGPNQPCHAHANCVSNKGAFTCVCKPGFQGDGYMCMESDPCALPHRGGCSKNAICIKTGPGTHKCKCLSGWREDGDECQAINNCLDPSRGGCHPNATCIYVGPGQIDCACKSGYHGNGRECEPVNQCVEQKGGCHFLATCQFLNPDGWHCVCEDGYAGDGKICYGTLLQEVSTNPDLLGFNQWISKAELSQLLSERENLTLFVPSAQAIEKMSKEDKDIWMTPSNLPSLVKNHILSGSFTLSDLNTSPSPPPRLVSLLKRTLPVYSTNDTTIVAGGKITFGDMAAKNGVIHLIDTVLIPEQQMSEGLLQVLKKRSDLSLFYGSLLNHNLTNEMEESLGFTVFAPTDNAIQDYLKRTGKESLDLNVTMYHIILTEILKDVDLVDGLYKDTMLGFQYQLGFFRQDKRLLVNEAEVNVTDLETSKGVIHIISAVLNIPSNRCDKATSILFSGRCMDCFQTIINPCPSGTKKVMSRKRRCMYSRVLHGDTLLTIGCKFSCEKMTIERICCSGHYGINCEKCPGSEDQSCFGNGICKDGINGTGVCLCNQGFNGTACESCQPGKYGIHCDQECKCVHGRCKDGIDGDGSCACDLGWRGVNCDIAIKSDMCGGKCHSSANCLVNVVDSSYYCSCAAGFQGNGTYCEAIDACAERNGGCSAHAVCKRTLPGRRICMCHPGYAGDGNVCTSINPCLDGVNGGCHADSNCIHTGPNKTACHCKEGFYKDGKNCELINLCKEKNGGCHRAAICTMTGPLQRNCTCHAGYVGDGEICKYTLQRELSIETARTAFVKAMFKNRIYELDTRGPFTVFAFRSENYKNQSIDLVKRTPENTRIMRYHIVCCRTLLPQDLMQPRNLTTLSGDILSITYSENTIYINNKAKVLFSDIESSNGILHEIDSVLVPPGLEIREDKKQDIIPRNFSEVASANGFKTFFKLLEDTDTLKLVMDPIHQPVTLFMPTDDAMSALSQEQKDFLYAMHNRDKLSEYLRYHILRDTKLMASELIYASSLKTQQGSDLSVACMGEEQIGELYVNHKGCRIVKRYLDFNGGMIYGIECLLNPPSLGGRCDHRQTIDFTLACRSCGSSIMDCPLGSKPVGEQECVLPDSVISRGSKCQSTCKVVVWKPKCCSGYYGRDCLACPGGPQSPCSNHGKCDEDHLGNGTCTCDTGFTGVACESCLDGHFGPDCNACNCTEHGSCDEGLQGTGSCFCEEGWTGPQCENKLADGPVCNPACHEKGVCMENNTCVCKPFYEGDGITCTVANMCKYWNGGCSKDAKCSQKGEKVSCACLQGFSGDGFVCTPIDPCVDGENGGCHEHATCTMTGPGKRKCECKDSYVGDGIDCEAKVLPVNRCLVDNGQCHSDAQCTDLHHEDKTLGVFHYRSTNGTYKLNYTMAQEACKEAGSTIATYMQLSYAQQAGYSLCTAGWLDKARVAYPMSFSSPRCGSGHVGIVDYGVRNNLSETWDTFCYRVKDVQCKCKTGYIGDGFSCTGNLMQVLSATPTLSNFLSQILNFSTSASGKAFVNRLRNITIQSTLFVPDNDGLYSNQTLSGRDIEHHLLDGRALILQALINVTHVRTRLGSSLTITGVPDLQNPQKMTSSGYINDRYVIDSNIFASNGVIHVLQGPLKAPPPPTPSFHPAHQAGLGIGVLGLIILIVVAGFVGYNFYTHKTKPFQFHYFKEDEGEDVTPTESSPNISNPVYDAAPATKEQPPTEEDKHQVISSGVFDLLQDS
InterPro domains: - IPR000538: Link domain (domain) [2186-2281]
- IPR016187: C-type lectin fold (homologous_superfamily) [2178-2284]
- IPR000742: EGF-like domain (domain) [103-2155]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [2188-2284]
- IPR056806: Stabilin-1/2, EGF-like domain (domain) [769-1417]
- IPR002049: Laminin-type EGF domain (domain) [106-2051]
- IPR001881: EGF-like calcium-binding domain (domain) [103-1545]
- IPR000782: FAS1 domain (domain) [354-2441]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [100-324]
- IPR036378: FAS1 domain superfamily (homologous_superfamily) [375-2440]
- IPR024731: NELL2-like, EGF domain (domain) [239-2154]
Interaction partners: - Protein SLX4IP
- Scavenger receptor class F member 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0038024 (cargo receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051094 (positive regulation of developmental process), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0060429 (epithelium development), GO:0060837 (blood vessel endothelial cell differentiation), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0030855 (epithelial cell differentiation), GO:0003158 (endothelium development), GO:0045446 (endothelial cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)