Protein: Endoplasmin homolog (92 kDa phosphoprotein) (Glucose-regulated protein 94 homolog) (GRP-94 homolog) (Q9NKX1)
Organism: Dictyostelium discoideum (Social amoeba)
Function: May play a role in late differentiation as well as in starvation response. When overexpressed, suppresses the ability to form normal fruiting bodies and impairs prespore differentiation as well as maturation into spores.
Subcellular location: Endoplasmic reticulum. Golgi apparatus. Note=In prespore cells, preferentially localizes in Golgi vesicles and cisternae. Colocalizes with trap1 in the prespore-specific vacuole.
Sequence: MKSITKIFLILGLFAFLLVAFAPSSSVATVNLESDGYTEAEAKLIEEKGEKFTFQTEVNKLMNIIINSLYSKKEIFLRELISNASDALDKIRFLALTNADLLGEGEQSNLDIHIKIDKANNVLHITDRGVGMTKDELVRNLGTIAQSGTKEFIKKVSDSAESSNLIGQFGVGFYSLFLVADSVVVTSKSNDDDQYVWTSDSQSSYTIAKDPKGNTLGRGTRISLHIKDDSKEFLDQEVIKQLVKKYSQFINFPIYLYVSEEVEIPKEEQEDSKPITDDQVEETTTTTEEGEEETTTEEEGQTEEKKTKTVYKWEELNDSKPLWMKAAKDVTKEEYTEFFRSLSKTQDTPITYSHFKTEGDTEFRSILYIPENPPSNMFDLEAAGSGLKLFVRRVFITDNLKELVPNWLRFLVGVIDSDDLPLNVSREMLQQNKILDAIKKKVILVKFISMIKELSEDEDKTKYNEFFKKFGSSMKLGAIEDQANKKRLTKYLLFPSSKEELTTFAGYVERMKEGQDQIYFITGKSKDSVEASPLIEQAIKKGYEVLFLVDPIDEYLVPQLDKFDDKYKFTNLARSGVKFNEDKEEEDQRKQTAEEFKPLLSYLKKTLSDKLEKVVISKVLADSPSILVSNSWGVTANQERIMKAQAHQANAQPQFNSKKIMEINPSHPLIKKLLNRLNEFGEEDETTKVSAHVLYETSALTAGYSIDNPTNFADFIYKLMMINGDSLAQTNFETTKNENSGPSVSFGDDDENQQQDFQQPPQSTHDEL
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [36-275]
- IPR001404: Heat shock protein Hsp90 family (family) [25-764]
- IPR037196: HSP90, C-terminal domain (homologous_superfamily) [576-722]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [72-230]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [319-566]
- IPR020575: Heat shock protein Hsp90, N-terminal (domain) [50-254]
Interaction partners: - Protein SGT1 homolog
- Calreticulin
- Luminal-binding protein 1
- Luminal-binding protein 2
- Calnexin
- Activator of 90 kDa heat shock protein ATPase homolog
- Heat shock 70 kDa protein, mitochondrial
- J domain-containing protein
- Heat shock factor-type DNA-binding domain-containing protein
- CS domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0043934 (sporulation), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0030435 (sporulation resulting in formation of a cellular spore), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)