wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Inner membrane protein YgjV (P42603)
Organism: Escherichia coli (strain K12)
Function: Not known
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Sequence: MTAYWLAQGVGVIAFLIGITTFFNRDERRFKKQLSVYSAVIGVHFFLLGTYPAGASAILNAIRTLITLRTRSLWVMAIFIVLTGGIGLAKFHHPVELLPVIGTIVSTWALFCCKGLTMRCVMWFSTCCWVIHNFWAGSIGGTMIEGSFLLMNGLNIIRFWRMQKRGIDPFKVEKTPSAVDERG
InterPro domains: - IPR026267: Inner membrane protein YgjV (family) [1-182]
- IPR019629: Uncharacterised protein family HI1736/YgjV (family) [5-163]
Interaction partners: - Probable D,D-dipeptide transport system permease protein DdpC
- Inner membrane protein YiaB
- Inner membrane protein YigG
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015144 (carbohydrate transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015355 (secondary active monocarboxylate transmembrane transporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0008028 (monocarboxylic acid transmembrane transporter activity), GO:0015295 (solute:proton symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034219 (carbohydrate transmembrane transport), GO:0006810 (transport), GO:0015749 (monosaccharide transmembrane transport), GO:0071702 (organic substance transport), GO:0008645 (hexose transmembrane transport), GO:0008643 (carbohydrate transport), GO:1904659 (glucose transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Neuronal pentraxin-2 (NP2) (Neuronal pentraxin II) (NP-II) (P47972)
Organism: Homo sapiens (Human)
Function: Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
Subcellular location: Secreted {ECO:0000250}.
Sequence: MLALLAASVALAVAAGAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELRAAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL
InterPro domains: - IPR030476: Pentaxin, conserved site (conserved_site) [311-318]
- IPR001759: Pentraxin-related (family) [219-424]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [242-419]
- IPR051360: Neuronal Pentraxin and Related (family) [107-427]
Interaction partners: - Neuronal pentraxin receptor
- Vasopressin-neurophysin 2-copeptin
- Glutamate receptor 4
- Neuroligin-1
- Reticulocalbin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0009966 (regulation of signal transduction), GO:0050804 (modulation of chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0098978 (glutamatergic synapse)
Protein: N(2)-fixation sustaining protein CowN (CO weal-nitrogenase) (Q2RNI5)
Organism: Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
Function: Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO. Is not required for CO-dependent growth.
Sequence: MTMDGPAHMPRRYVTFQGVNVEGLSQQLIARILFHVADPAKSNAFWEHFKAKLADADKTLARTADSLCLLCGAIGYIDELFEDNDDEEGLTILRRLEDELC
InterPro domains: - IPR024899: Nitrogen fixation-sustaining protein CowN (family) [6-101]
Interaction partners: - CO-responsive transcriptional regulator RcoM
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019068 (virion assembly), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019028 (viral capsid)
Protein: GGDEF domain-containing protein (Q54R09)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Sequence: MEKSIQELFLSTLNIYSYINSGNPTSTLYKSQISNNKVNDTIDSTTYNHDNNNNNNNNNNNNNNNNNNYYINNNNNNNNYNYNNNYMQYNQMNNNSNLYITKDNMLFLLIVVVLIYTFIQRERKMLSETNTFKQILNYTPTLIVLEINFAQKVVNTINPVLTKSNSSNNLTQYLNTNTNTNTNTNTNNNENNNNNNINNNNNNNNNNSSNNNNNSSSNNINILNNNNILNKSVKIVNNNNNNSTEEFNNNNNNNSNNNNNNIEQTQTTSDKYFSIQSFCESLNIDPNDFVLALNNNSNNDEQDIQNSKGIVLKSIDGTKKYRFSGKCNKSVFRGLVLDISEEVSELKKLKYILAHDPLTGLPNRYRLDEKIQKFCNKSETDLCALYFMDLNKFKSINDTYGHEVGDLVLKHVSNQFKAQKDSNVLPIRLSGDEFLIIKRGVENVDHADHFISQFTKNVSSSSFTVDGESSSTILPIFFSYGGVVFKKSETKVSSIIKSADEKMYQMKKGISQINVVEFEKN
InterPro domains: - IPR043128: Reverse transcriptase/Diguanylate cyclase domain (homologous_superfamily) [347-520]
- IPR000160: GGDEF domain (domain) [342-518]
- IPR052163: Diguanylate Cyclase/Regulatory Protein (family) [248-511]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [358-508]
Interaction partners: - Probable dihydroxyacetone kinase
- Succinate dehydrogenase iron-sulfur subunit, mitochondrial
- Succinate dehydrogenase flavoprotein subunit, mitochondrial
- Glycerol kinase 5
- Probable glycerol kinase
- Cytochrome c1, heme protein, mitochondrial
- Succinate dehydrogenase cytochrome b560 subunit
- Cytochrome b-c1 complex subunit Rieske, mitochondrial
- NADH-ubiquinone oxidoreductase 23 kDa subunit
- Inositol monophosphatase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0052621 (diguanylate cyclase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0043207 (response to external biotic stimulus), GO:0009617 (response to bacterium), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0010256 (endomembrane system organization), GO:0007005 (mitochondrion organization), GO:0007030 (Golgi organization), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0007032 (endosome organization), GO:0031175 (neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Uncharacterized protein C13E7.11 (O14364)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MNRLNFQSLLWKFGQKRFYYRPWIRIENIKPTPLWKPITFAVGVGSATFYTANYLDKRRKNYPKSSYGFPIPQTSSRSLVLSIIGINVGVFALWRAPRFSHLNRFLQKYAVMNPIFINMPSMIVSAFSHQSGWHLLFNMVAFYSFAPAIVDVFGNNQFVAFYISSILFSNVASLLHHRLRFGTKVTPGSLGASGAIYAIAAATSYFFPNASVSIIFLPFIPIKIGVALLGLMAFDAWGLISRGFSSFANFTLIDHAAHLGGGIFGWLYAKYGYSTYNRSTRPRPPSLSKPFFSRSVSF
InterPro domains: - IPR035952: Rhomboid-like superfamily (homologous_superfamily) [73-276]
- IPR022764: Peptidase S54, rhomboid domain (domain) [122-271]
- IPR050925: Rhomboid protease S54 (family) [56-271]
Interaction partners: - Rhomboid-type serine protease 2
- Mitochondrial inner membrane m-AAA protease component yta12
- Uncharacterized protein C18B11.08c
- Large ribosomal subunit protein uL30C
- Transmembrane GTPase fzo1
- Amino-acid permease 1
- Pyridoxal phosphate homeostasis protein
- Uncharacterized protein C56F8.13
- Uncharacterized protein C56F8.15
- Putative uncharacterized transmembrane protein SPBC713.13.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0017171 (serine hydrolase activity), GO:0008233 (peptidase activity), GO:0008236 (serine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004252 (serine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0051604 (protein maturation), GO:0006508 (proteolysis), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0007005 (mitochondrion organization), GO:0048284 (organelle fusion), GO:0016485 (protein processing), GO:0008053 (mitochondrial fusion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protein kinase, putative (C4MBQ2)
Organism: Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
Function: Not known
Sequence: MSTPYSSIRNIIKEGCVVKQGHIIWNWYNRWLVLTKEQLYYYDESKQKLRGTVPLDFASVKSCEIEDHPFSFEVYCPTQNKTYFFEALSEEERTSWIKKISEVVDISEPTDYHHLTHVAYEEGGFVGIPYEWENVFLACGITREEIKSNKEDAIKVLEFTQIFQDDETEETQKQPLPENDVPVVLKELITSGDPTVLYKDYVPIGEGMSGVVFHCYETSTNKEVAMKKILIKNDSVNIQEIKIMQTLNQRNIVGYLGCYELDNYLYIAMEYMDRNNLTAMLDFFPEFSLSERHIAYVVHESNTALKYLHSLHRIHRDIKSDNILLNHRGEIKLADFGISVQLTKRKSKRNTVVGTPYWMAPEVIKGKDYGTNIDIWSLGIMCREMMEGVPPYIDDPPLRALFKISTKGIPPVQYGDYTPTILDFVDKCLTFDPTKRPDCEELDKDPFMSLACSREEFAEFIQKIVQQAEK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [198-449]
- IPR001849: Pleckstrin homology domain (domain) [10-107]
- IPR000719: Protein kinase domain (domain) [198-448]
- IPR000095: CRIB domain (domain) [105-160]
- IPR017441: Protein kinase, ATP binding site (binding_site) [204-227]
- IPR051931: Serine/threonine-protein kinase PAK 3-like (family) [119-464]
- IPR036936: CRIB domain superfamily (homologous_superfamily) [106-176]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [3-105]
Interaction partners: - SH3 domain-containing protein
- DH domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0048584 (positive regulation of response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043410 (positive regulation of MAPK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Sigma factor regulatory protein PupR (Q4KDP8)
Organism: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Function: Not known
Sequence: MHPSRRQPGLAVNHPLSSNANAEPQSIDIAMAEQAMQWQLDLQEPQVSAATLAAWHRWRQAHPLHEKAWQRAETLAQRLQQVRSQGHSELARATLVPNLGRRRALKQLGLLLVTGAGAWAARDTALVQDWSADYSTRVGQQRRITLADQTRVQLNTDTAIALRFDREQRRIKLLRGELLLTLARQDSLPALHVETAEGWIETSTARFSVRQLAGRTELSVYQGNLTLRPRDGGQPALSLGAGEQARFNRQGLLLRQAQNATQPAWSQGMLVAQGQALAQFLEELGRYRHGHLGCDPSLAQLKVSGTFPLADTDRVLFAVARTLQLEVRQFTRYWVTLKPRTALS
InterPro domains: - IPR006860: FecR protein (domain) [133-224]
- IPR032623: FecR, N-terminal (domain) [33-75]
- IPR012373: Fe(2+)-dicitrate sensor, transmembrane component (family) [22-340]
Interaction partners: - RNA polymerase sigma factor PupI
- TonB-dependent outermembrane ferripyoverdine receptor
- RNA polymerase sigma factor FecI
- RNA polymerase sigma-70 factor, ECF family
- RNA polymerase sigma factor, FecI family
- RNA polymerase sigma-70 factor, ECF family
- RNA polymerase sigma-70 factor, ECF family
- RNA polymerase sigma-70 factor, ECF family
- RNA polymerase sigma factor, sigma-70 family
- RNA polymerase sigma-70 factor, ECF family
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003712 (transcription coregulator activity), GO:0003714 (transcription corepressor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Zinc metalloproteinase barnettlysin-1 (EC 3.4.24.-) (Barnettlysin-I) (Snake venom metalloproteinase) (SVMP) (P86976)
Organism: Bothrops barnetti (Barnett's lancehead) (Trimeresurus barnetti)
Function: Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen and fibrin but has no activity on beta- and gamma-chains. Cleaves X-Leu bonds. Inhibits platelet aggregation induced by the von Willebrand factor (VWF) (IC(50) is 1.4 uM) and type I collagen (IC(50) is 3.2 uM). Acts by cleaving the vWF and its receptor GPIb, and by cleaving the collagen-binding Alpha-2A domain of the collagen receptor alpha-2/beta-1 integrin (ITGA2/ITGB1). Also degrades the extracellular matrix protein fibronectin (FN1), but has no effect on laminin and type I collagen.
Subcellular location: Secreted {ECO:0000269|PubMed:26723171}.
Sequence: TPEQQRYVELFIVVDHGMFMKXXXXXXXXXXXIHQMVNIMKEAYRYLYIDILLTGVEIWSNKDLINVQPAAPQTLDSFGEWRXXXXXXXKSHDNAQLLTSTDFDGPTIGLAYVGSMCDPKRSTAVIQDHSEIDLLVAVTMDHELGHNLGIRHDTGSCSCGGYPCVMSPVISHDISKYFSDCSYIQCWDFIMKENPQCILNKR
InterPro domains: - IPR034027: Reprolysin domain, adamalysin-type (domain) [6-200]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [6-202]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [2-201]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0043169 (cation binding), GO:0008237 (metallopeptidase activity), GO:0004175 (endopeptidase activity), GO:0046872 (metal ion binding), GO:0000287 (magnesium ion binding), GO:0004222 (metalloendopeptidase activity), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0065008 (regulation of biological quality), GO:0051239 (regulation of multicellular organismal process), GO:1900046 (regulation of hemostasis), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0050818 (regulation of coagulation), GO:0032101 (regulation of response to external stimulus), GO:0030193 (regulation of blood coagulation), GO:0050878 (regulation of body fluid levels), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0006508 (proteolysis), GO:1903034 (regulation of response to wounding), GO:0061041 (regulation of wound healing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Membrane progestin receptor beta (mPR beta) (Lysosomal membrane protein in brain 1) (Membrane progesterone P4 receptor beta) (Membrane progesterone receptor beta) (Progesterone and adipoQ receptor family member 8) (Progestin and adipoQ receptor family member 8) (Progestin and adipoQ receptor family member VIII) (Q8TEZ7)
Organism: Homo sapiens (Human)
Function: Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.
Subcellular location: Cell membrane {ECO:0000269|PubMed:11676489, ECO:0000303|PubMed:23763432}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with a lysosomal protein CTSD/cathepsin D. {ECO:0000269|PubMed:11676489}.
Sequence: MTTAILERLSTLSVSGQQLRRLPKILEDGLPKMPCTVPETDVPQLFREPYIRTGYRPTGHEWRYYFFSLFQKHNEVVNVWTHLLAALAVLLRFWAFAEAEALPWASTHSLPLLLFILSSITYLTCSLLAHLLQSKSELSHYTFYFVDYVGVSVYQYGSALAHFFYSSDQAWYDRFWLFFLPAAAFCGWLSCAGCCYAKYRYRRPYPVMRKICQVVPAGLAFILDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCDIVGHGHQIFHAFLSICTLSQLEAILLDYQGRQEIFLQRHGPLSVHMACLSFFFLAACSAATAALLRHKVKARLTKKDS
InterPro domains: - IPR004254: AdipoR/Haemolysin-III-related (family) [37-307]
Interaction partners: - EF-hand domain-containing protein 1
- Membrane-associated progesterone receptor component 1
- Membrane-associated progesterone receptor component 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0034097 (response to cytokine), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:1990823 (response to leukemia inhibitory factor), GO:0071345 (cellular response to cytokine stimulus), GO:1990830 (cellular response to leukemia inhibitory factor)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)