Protein: 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor (12-(S)-HETE receptor) (12-HETER) (G-protein coupled receptor 31) (F8VQN3)
Organism: Mus musculus (Mouse)
Function: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (By similarity). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes, such as cell growth, adhesion, inflammation and cancer promotion. 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways and leads to cell growth. Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (By similarity). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens. Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O00270}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MERTNCSAASTVVETAVGTMLTLECVLGLMGNAVALWTFFYRLKVWKPYAVYLFNLVVADLLLATSLPFFAAFYLKGKTWKLGHMPCQVLLFLLAFSRGVGVAFLTTVALDRYLRVVHPRLRVNLLSLRAAWGISSLIWLLMVVLTPQNLLTCRTTQNSTECPSFYPTGGAKAIATCQEVLFFLQVLLPFGLISFCNSGLIRTLQKRLRESDKQPRIRRARVLVAIVLLLFGLCFLPSVLTRVLVHIFQEFKSCSVQQAIVRASDIAGSLTCLHSTLSPAIYCFSNPAFTHSYRKVLKSLRGRRKAAESPSDNLRDSYS
InterPro domains: - IPR051893: Hydroxycarboxylic Acid Receptors (family) [2-316]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [31-282]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [16-290]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0008289 (lipid binding), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005504 (fatty acid binding), GO:0004888 (transmembrane signaling receptor activity), GO:0043177 (organic acid binding), GO:0043168 (anion binding), GO:0036041 (long-chain fatty acid binding), GO:0031406 (carboxylic acid binding), GO:0004930 (G protein-coupled receptor activity), GO:0033293 (monocarboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0097305 (response to alcohol), GO:0032870 (cellular response to hormone stimulus), GO:1901654 (response to ketone), GO:0070633 (transepithelial transport), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0034694 (response to prostaglandin), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006821 (chloride transport), GO:1901655 (cellular response to ketone), GO:0071379 (cellular response to prostaglandin stimulus), GO:0034695 (response to prostaglandin E), GO:0097306 (cellular response to alcohol), GO:0006820 (monoatomic anion transport), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0071380 (cellular response to prostaglandin E stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)