Protein: Interleukin-1 receptor accessory protein (Q9NPH3)
Organism: Homo sapiens (Human)
Function: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable)
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein
Sequence: MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQGLSYSSLKNV
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [32-347]
- IPR041416: IL-1Ra-like, immunoglobulin domain (domain) [69-139]
- IPR007110: Immunoglobulin-like domain (domain) [141-348]
- IPR015621: Interleukin-1 receptor family (family) [4-560]
- IPR004074: Interleukin-1 receptor type I/II (family) [40-269]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [18-352]
- IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [394-550]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [403-562]
- IPR003599: Immunoglobulin domain subtype (domain) [32-350]
Interaction partners: - Interleukin-33
- Interleukin-1 receptor type 1
- Interleukin-1 receptor-like 1
- Interleukin-1 beta
- Interleukin-1 receptor type 2
- Interleukin-1 alpha
- Interleukin-1 receptor-like 2
- Receptor-type tyrosine-protein phosphatase delta
- Myeloid differentiation primary response protein MyD88
- Interleukin-18 receptor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0006955 (immune response), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0006954 (inflammatory response), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)