wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Transcription factor Sp9 (Q6NW96)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MATSILGEEPRFGTTPLAMLAATCNKIGNTSPLTTLPDSSAFSKGGFHPWKRSSSSCNLGSSLPGFTVATSRSTSGLTTTTGAGNSAFCLASTSPTSSAFSAEYSSLFSNTTSVSSQDSGQSAFISKVHSSADTLYPRVGMAHPYESWYKSGFHSTISGDVANGASTWWDVHTNPGSWLEVQNPAGTLQSSLHSGTPQAIHSQLSGYNPDFSSLTHSAFSSTGISPTASHLLSTSQHLLTQEGFKTVIPTYTDASATNAMISGASSGIGTSSRSSRRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHIKTHTAGGGGKKGSDSDTDTSNLETPRSESPELILEGVNPRVTVKDQSPHHES
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [308-391]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [322-391]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048736 (appendage development), GO:0009790 (embryo development), GO:0035107 (appendage morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0035108 (limb morphogenesis), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0030326 (embryonic limb morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Zinc-regulated transporter 3 (Vacuolar membrane zinc transporter) (P34240)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Transports zinc from storage in the vacuole to the cytoplasm.
Subcellular location: Vacuole membrane {ECO:0000269|PubMed:10856230}; Multi-pass membrane protein {ECO:0000269|PubMed:10856230}.
Sequence: MEKIPRWLLFSLISSVLCILGALCVPLLSVAFDSKRNSQSKLVNYGLSLSAGSMITTSLYMLLPRIEKSNRFKVFPGLLLGICLSFFLNYLVHAFASESLVHCADSGDHATGSHIHSKSHSHSHSHSHADSHSNFSNDHDLENAPSEHGYATSSSSVSENDPLITKDSDRPQMKKKMSLIDLLTRRKSEGECCDLNKCTPLLQSEQPEYIACVPPVIKSSQSERNVPHGCEGSEDNGQSDDKDHRGLVCVENNIGYDLENLSLYRKNFLSSRHHHSSESPENYGSNQLSHSFSSPLGNDVTENPAALADTQYHPENGSLYPHHHHLETPFSKLLSIGMQTCLVLALHKFPEGFIIFYTNRSDSSKSLGFSIFLSLTIHNFVEGFAMTLPFYTVFESKWVAILITAVLGGGSQPLGALIGYFIFKGSTPRDHEPNMDFLLSVTAGFLLVIGLQMFQTGIGFSDGHHHHQGEGDEEMKQSHSSGTTCLKWCCTGVLLILASALFT
InterPro domains: - IPR003689: Zinc/iron permease (family) [12-455]
Interaction partners: - Zinc-regulated transporter 1
- Zinc-regulated transporter 2
- Vacuolar zinc transporter ZRC1
- Vacuolar zinc transporter COT1
- Zinc-responsive transcriptional regulator ZAP1
- Probable zinc transporter MSC2
- Zinc transporter YKE4
- Low-affinity Fe
- Protein ZRG17
- Metal homeostasis factor ATX2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006882 (intracellular zinc ion homeostasis), GO:0055080 (monoatomic cation homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole), GO:0098852 (lytic vacuole membrane), GO:0000329 (fungal-type vacuole membrane)
Protein: Protein OSCP1 (Q8BHW2)
Organism: Mus musculus (Mouse)
Function: May be involved in drug clearance in the placenta.
Subcellular location: Basal cell membrane {ECO:0000250}.
Sequence: MSVRTLPLLFLNLGGEMLYVLDQRLRAQNIPGDKARKVLNDIISTMFNRKFMDELFKPQELYSKKALRTVYDRLAHASIMRLNQASMDKLYDLMTMAFKYQVLLCPRPKDVLLVTFNHLDAIKGFVQDSPTVIHQVDETFRQLSEVYGKLSEGEFQLIRQTLLNFFQDLHIRVSTFLKDKVQNSNGRFVLPVSGPVPWGTEVPGVIRVFSVKGKEVKKMKFRHGGDYVAAQKEGSFELYGDRVLKLGTNMYSASRPVETHMSATSKNAASRAQENIVPNPLAKEELNFLARLMGGMEIKKPSGPEPGFRLNLFTTDEEEEHAALSRPEELSYEVISIQATQDQQRNEELARIMGEFEITEQLEQNTSKGDDLLAMMDRL
InterPro domains: - IPR019332: Organic solute carrier protein 1 (family) [1-378]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098862 (cluster of actin-based cell projections), GO:0005903 (brush border)
Protein: Fructosamine-3-kinase (EC 2.7.1.171) (Protein-psicosamine 3-kinase FN3K) (Protein-ribulosamine 3-kinase FN3K) (EC 2.7.1.172) (Q9H479)
Organism: Homo sapiens (Human)
Function: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Involved in intracellular deglycation in erythrocytes. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (By similarity). Also able to phosphorylate psicosamines and ribulosamines.
Sequence: MEQLLRAELRTATLRAFGGPGAGCISEGRAYDTDAGPVFVKVNRRTQARQMFEGEVASLEALRSTGLVRVPRPMKVIDLPGGGAAFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKLKEEENTVGRRGEGAEPQYVDKFGFHTVTCCGFIPQVNEWQDDWPTFFARHRLQAQLDLIEKDYADREARELWSRLQVKIPDLFCGLEIVPALLHGDLWSGNVAEDDVGPIIYDPASFYGHSEFELAIALMFGGFPRSFFTAYHRKIPKAPGFDQRLLLYQLFNYLNHWNHFGREYRSPSLGTMRRLLK
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [21-307]
- IPR016477: Fructosamine/Ketosamine-3-kinase (family) [1-309]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043687 (post-translational protein modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Steroid sulfatase (microsomal), isozyme S (Steryl-sulfatase isoform X1) (F1QB82)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MKSFQWIPCTFCLLLYTADAGSGTKPNFVFMMVDDLGIGDLGCYGNTTLRTPNIDRLALEGVKLTQHIAAAPLCTPSRAAFLTGRYPIRSGMAAHGHMGVFLFSASSGGLPQEEITFAKAVKVQGYSTAVIGKWHLGLNCEDSSDHCHHPNSHGFDYFYGTIMTHLRDCQPGHGSVLYNVYSHIPFKPLSIGLVSLVVLHIRGMLTVSRRVFFSFLILVGLVLSLFRLLVYTFPNLNCFVMRGTEIVEQPYISENLTQRMTSEAIEFLERNSETPFLLFFSFIQVHTGVFASPLFRGRSQHGLYGDAVMEVDWSVGQIMQTLERLNLKDNTLVYMTSDQGPHLEEISVHGEMHGGYSGIYKAGKSTNWEGGIRIPGILSWPGVLPAGNIIDEPTSNMDIFPTVLNLAGASIPDDRVIDGHDLLPLLQGQVKRSEHELLFHYCNAELNAVRWRPPNSSAIWKAFFFTPDFYPKNSSACFHTHVCFCIKPFVTFHDPPLLYDLSKDPTESTPLSPDTEPQFHSVLEVIRAAVSRHTQSLKPVPVQVSPLKIVWKPWLQPCCSSLSQLCRCERDHQIEKVQDGLQKE
InterPro domains: - IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [23-569]
- IPR050738: Sulfatase enzyme (family) [11-552]
- IPR024607: Sulfatase, conserved site (conserved_site) [72-135]
- IPR000917: Sulfatase, N-terminal (domain) [26-409]
Interaction partners: - Sulfotransferase
- Sulfotransferase
- Cytochrome P450, family 3, subfamily A, polypeptide 65
- Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
- Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
- Cytochrome P450, family 17, subfamily A, polypeptide 1
- Cytochrome P450 1A
- Cytochrome P450, family 17, subfamily A, polypeptide 2
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Cholesterol side-chain cleavage enzyme
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009888 (tissue development), GO:0048513 (animal organ development), GO:0031214 (biomineral tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: AGAMOUS-like 52 (MADS-box protein AGL52) (Q9SUT6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MKQASSSSSCNPTSLTNRLKTIFKKAEELSILCAIDVCVIYYGPDGDLRTWPKDRETVKNMALRYKEDRKRKKCLNLHEFLEKEKVKDKDKYKGKTNYVKNPNWYPNFDHYSPQQLSQLIQSLERTLSTLQKRLRIVESQKKQNTNLVHQSLTPSYLNQTQHLDPSKFSLYMYNHGDATLSQLPLSASQSNQLINYQMQHGFGQNMCLDNITNNNNFQHPGVSNTQDYSPLLSANNYGLNNHLMQQQDQLHGFDQNLCMMSEIINNNNGLQHPNLSNTVPHEFPYGNTSFSQDMFSSYDGSSLLQTSSLPPLHNIPNSYCFSDNSRLLC
InterPro domains: - IPR002100: Transcription factor, MADS-box (domain) [1-55]
- IPR036879: Transcription factor, MADS-box superfamily (homologous_superfamily) [12-90]
Interaction partners: - Protein argonaute 10
- Switch 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0090698 (post-embryonic plant morphogenesis), GO:0099402 (plant organ development), GO:1905393 (plant organ formation), GO:1905392 (plant organ morphogenesis), GO:0048731 (system development), GO:0090696 (post-embryonic plant organ development), GO:0010311 (lateral root formation), GO:0048364 (root development), GO:0022622 (root system development), GO:0048528 (post-embryonic root development), GO:0010015 (root morphogenesis), GO:0090697 (post-embryonic plant organ morphogenesis), GO:0048527 (lateral root development), GO:0010101 (post-embryonic root morphogenesis), GO:0010102 (lateral root morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0090406 (pollen tube)
Protein: Progonadoliberin-1 (Progonadoliberin I) (B7TCB2)
Organism: Taeniopygia guttata (Zebra finch) (Poephila guttata)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MEKPRRRMVATVLLCVLAVGLGLAQHWSYGLQPGGKRSTQLLLGPFQEIANEMEKLEEEQQSACPGSHQNSRSGALREAMERLLEEQGRRKNV
InterPro domains: - IPR019792: Gonadoliberin (family) [1-87]
- IPR002012: Gonadotropin-releasing hormone (conserved_site) [25-34]
- IPR004079: Gonadoliberin I precursor (family) [25-85]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus), GO:0002237 (response to molecule of bacterial origin), GO:0033993 (response to lipid), GO:0032496 (response to lipopolysaccharide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection)
Protein: UPF0182 protein Rv0064 (P9WFL5)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Subcellular location: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01600}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01600}.
Sequence: METGSPGKRPVLPKRARLLVTAGMGMLALLLFGPRLVDIYVDWLWFGEVGFRSVWITVLLTRLAIVAAVALVVAGIVLAALLLAYRSRPFFVPDEPQRDPVAPLRSAVMRRPRLFGWGIAVTLGVVCGLIASFDWVKVQLFVHGGTFGIVDPEFGYDIGFFVFDLPFYRSVLNWLFVAVVLAFLASLLTHYLFGGLRLTTGRGMLTQAARVQLAVFAGAVVLLKAVAYWLDRYELLSSGRKEPTFTGAGYTDIHAELPAKLVLVAIAVLCAVSFFTAIFLRDLRIPAMAAALLVLSAILVGGLWPLLMEQFSVRPNAADVERPYIQRNIEATREAYRIGGDWVQYRSYPGIGTKQPRDVPVDVTTIAKVRLLDPHILSRTFTQQQQLKNFFSFAEILDIDRYRIDGELQDYIVGVRELSPKSLTGNQTDWINKHTVYTHGNGFVAAPANRVNAAARGAENISDSNSGYPIYAVSDIASLGSGRQVIPVEQPRVYYGEVIAQADPDYAIVGGAPGSAPREYDTDTSKYTYTGAGGVSIGNWFNRTVFATKVAQHKFLFSREIGSESKVLIHRDPKERVQRVAPWLTTDDNPYPVVVNGRIVWIVDAYTTLDTYPYAQRSSLEGPVTSPTGIVRQGKQVSYVRNSVKATVDAYDGTVTLFQFDRDDPVLRTWMRAFPGTVKSEDQIPDELRAHFRYPEDLFEVQRSLLAKYHVDEPREFFTTNAFWSVPSDPTNNANATQPPFYVLVGDQQSAQPSFRLASAMVGYNREFLSAYISAHSDPANYGKLTVLELPTDTLTQGPQQIQNSMISDTRVASERTLLERSNRIHYGNLLSLPIADGGVLYVEPLYTERISTSPSSSTFPQLSRVLVSVREPRTEGGVRVGYAPTLAESLDQVFGPGTGRVATARGGDAASAPPPGAGGPAPPQAVPPPRTTQPPAAPPRGPDVPPATVAELRETLADLRAVLDRLEKAIDAAETPGG
InterPro domains: - IPR005372: Uncharacterised protein family UPF0182 (family) [1-970]
Interaction partners: - Cyclo
- Esterase Rv1288
- Ribonuclease VapC1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044085 (cellular component biogenesis), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0016043 (cellular component organization), GO:0044249 (cellular biosynthetic process), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Endoribonuclease MazF (EC 3.1.-.-) (MazFSa) (Toxin MazF) (mRNA interferase MazF) (A6QIR4)
Organism: Staphylococcus aureus (strain Newman)
Function: Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease, it cuts between the first and second nucleotides of 5'-UACAU-3'. Cleaves the artificial ssDNA-RNA substrate 5'-AAGTCrUrACATCAG-3' between rU and rA in vitro. Originally found to be a ribosome-independent, with a consensus sequence of 5'-[ACG]UU[ACG]-3' in single-stranded RNA. Its overexpression inhibits protein synthesis and induces bacterial stasis, it is neutralized by coexpression with cognate antitoxin MazE. Not all mRNAs are equally susceptible in vivo (gyrB, recA and sarA for example are not degraded), while no degradation of rRNA has been seen.
Sequence: MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRTLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN
InterPro domains: - IPR003477: mRNA interferase PemK-like (family) [1-112]
- IPR011067: Plasmid maintenance toxin/Cell growth inhibitor (homologous_superfamily) [1-120]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0046700 (heterocycle catabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0090304 (nucleic acid metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0016070 (RNA metabolic process), GO:0006401 (RNA catabolic process), GO:0034661 (ncRNA catabolic process), GO:0034660 (ncRNA metabolic process), GO:0016075 (rRNA catabolic process), GO:0016072 (rRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0005667 (transcription regulator complex), GO:0017053 (transcription repressor complex)
Protein: Cell number regulator 2 (ZmCNR02) (B6TYV8)
Organism: Zea mays (Maize)
Function: May act as a negative regulator of cell number.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MYPKAADEGAQPLATGIPFSGGGGYYQAGGAMAAAFAVQAQAPVAAWSTGLCNCFDDCHNCCVTCVCPCITFGQTAEIIDRGSTSCGTSGALYALVMLLTGCQCVYSCFYRAKMRAQYGLQVSPCSDCCVHCCCQCCALCQEYRELKKRGFDMSIGWHANMERQGRAAAAVPPHMHPGMTR
InterPro domains: - IPR006461: PLAC8 motif-containing protein (family) [43-167]
Interaction partners: - Zinc finger CCCH domain-containing protein 4
- BHLH transcription factor
- Transcription factor bHLH51
- BHLH transcription factor
- DNA binding protein
- BHLH transcription factor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)