Protein: Probable cyclic di-GMP phosphodiesterase PdeA (P23842)
Organism: Escherichia coli (strain K12)
Function: Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MFVEHNLIKNIKIFTLAFTLTVVLIQLSRFISPLAIIHSSYIFLAWMPLCVMLSILFIFGWRGVVPVLCGMFCTNLWNFHLSFLQTAVMLGSQTFVVLCACAILRWQLGTRWRYGLTSRYVWQRLFWLGLVTPIGIKCSMYLVGSFFDFPLKISTFFGDADAIFTVVDLLSLFTAVLIYNMLFYYLTRMIVSPHFAQILWRRDIAPSLGKEKRAFTLSWLAALSVLLLLLCTPYENDFIAGYLVPVFFIIFTLGVGKLRYPFLNLTWAVSTLCLLNYNQNFLQGVETEYSLAFILAVLISFSVCLLYMVRIYHRSEWLNRRWHLQALTDPLTLLPNFRALEQAPEQEAGKSFCCLRIDNLEFMSRHYGLMMRVHCIRSICRTLLPLMQENEKLYQLPGSELLLVLSGPETEGRLQHMVNILNSRQIHWNNTGLDMGYGAAWGRFDGNQETLQPLLGQLSWLAEQSCAHHHVLALDSREEMVSGQTTKQVLLLNTIRTALDQGDLLLYAQPIRNKEGEGYDEILARLKYDGGIMTPDKFLPLIAQFNLSARFDLQVLESLLKWLATHPCDKKGPRFSVNLMPLTLLQKNIAGRIIRLFKRYHISPQAVILEITEEQAFSNAESSMYNIEQLHKFGFRIAIDDFGTGYANYERLKRLQADIIKIDGVFVKDIVTNTLDAMIVRSITDLAKAKSLSVVAEFVETQQQQALLHKLGVQYLQGYLIGRPQPLAD
InterPro domains: - IPR001633: EAL domain (domain) [487-729]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [331-436]
- IPR035919: EAL domain superfamily (homologous_superfamily) [476-729]
- IPR043128: Reverse transcriptase/Diguanylate cyclase domain (homologous_superfamily) [318-465]
- IPR050706: Cyclic di-GMP phosphodiesterase-like (family) [301-728]
- IPR007895: MASE1 (domain) [16-315]
- IPR000160: GGDEF domain (domain) [315-476]
Interaction partners: - Probable diguanylate cyclase DgcJ
- Probable diguanylate cyclase CdgI
- Diguanylate cyclase DgcP
- Cyclic di-GMP phosphodiesterase PdeH
- Probable diguanylate cyclase DgcC
- HTH-type transcriptional regulator XapR
- Diguanylate cyclase DgcN
- Probable diguanylate cyclase DgcF
- Probable diguanylate cyclase DgcI
- Diguanylate cyclase DgcM
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0008081 (phosphoric diester hydrolase activity), GO:0032561 (guanyl ribonucleotide binding), GO:0071111 (cyclic-guanylate-specific phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:1900190 (regulation of single-species biofilm formation), GO:0010035 (response to inorganic substance), GO:0006979 (response to oxidative stress), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:1901700 (response to oxygen-containing compound), GO:0034059 (response to anoxia), GO:0010033 (response to organic substance), GO:0034599 (cellular response to oxidative stress), GO:0071453 (cellular response to oxygen levels), GO:0062197 (cellular response to chemical stress), GO:0036293 (response to decreased oxygen levels), GO:0042542 (response to hydrogen peroxide), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0036294 (cellular response to decreased oxygen levels), GO:0034614 (cellular response to reactive oxygen species), GO:0070301 (cellular response to hydrogen peroxide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)