Protein: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) (P54750)
Organism: Homo sapiens (Human)
Function: Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.
Sequence: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
InterPro domains: - IPR003607: HD/PDEase domain (domain) [216-389]
- IPR023088: 3'5'-cyclic nucleotide phosphodiesterase (family) [214-395]
- IPR013706: PDE1, N-terminal domain (domain) [73-133]
- IPR023174: 3'5'-cyclic nucleotide phosphodiesterase, conserved site (conserved_site) [259-270]
- IPR036971: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily (homologous_superfamily) [138-525]
- IPR002073: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain (domain) [142-522]
Interaction partners: - Calmodulin-1
- Calmodulin-like protein 5
- Calmodulin-like protein 3
- Calmodulin-like protein 4
- Calmodulin-like protein 6
- Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- GMP reductase 1
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004112 (cyclic-nucleotide phosphodiesterase activity), GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity), GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0048660 (regulation of smooth muscle cell proliferation), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:1901136 (carbohydrate derivative catabolic process), GO:0043067 (regulation of programmed cell death), GO:0019693 (ribose phosphate metabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0046434 (organophosphate catabolic process), GO:0009261 (ribonucleotide catabolic process), GO:0009259 (ribonucleotide metabolic process), GO:0072523 (purine-containing compound catabolic process), GO:0042981 (regulation of apoptotic process), GO:1901292 (nucleoside phosphate catabolic process), GO:0009117 (nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0009154 (purine ribonucleotide catabolic process), GO:0052652 (cyclic purine nucleotide metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009187 (cyclic nucleotide metabolic process), GO:0010660 (regulation of muscle cell apoptotic process), GO:0009166 (nucleotide catabolic process), GO:0006195 (purine nucleotide catabolic process), GO:0009214 (cyclic nucleotide catabolic process), GO:0034391 (regulation of smooth muscle cell apoptotic process), GO:0046068 (cGMP metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)