Protein: Argonaute (B6K0R2)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Sequence: MKPKTDLVLRSNYDKYSKDGYGTIGRPITLLSNFYRIENLPNDTIYQYHVVIGDGTRVPRKLVNKIWNSEDVKKFLKKSWKNCVFDGRSLLFSKDKIEDGATDVVVDPDRPERKVAFAIQRTSNINLETVTQFVQSRYSLDPQVLGGIMFLDLLLKKTPSETLYGFNRSFFTGNRPYQLGGGLDAWKGFYQSIRPGQGFMTVNIDVCTSAFWREDSLLRVLLDYTNRHHPNDLERMQLAAIGRRFRLLKVTCQHRNNAGTALSKKQYSIERFSSGSALDETFLRRVPNSDKEERISVADYFLEHHNVRLEFPNLPCAIIKNGAKLPLELCYIVKGQRYSAKLNSNQTAQMIRFACQRPHERVKDIEQFVHSSAWDKDPNLKEYGMRISRNMLDVPARILDAPRIMYHDDYEHPRDGRWNLRGKRFLITPDRPVRSWAVVCFLPTRILPNNKIENFLRTYVNTLTGLGISFECKNPRIYRQDPRGNLEGLLGDVIKKTADFHRATPDYLFFILDSNSPEPYATIKRLCNTKFGIPSQCALRKHIEGAKPQYCANLGMKVNAKLGGVNVHLEPKSFPLGNIPTIILGGDVYHPARGGSGASIGSMVGSIDLHGCKYTAMSRAQNRNQEMIQGMKDMVVYFLQGFRHITKKEPAQIIYFRDGVSDGQFKQVVDEELAEIKQACYFLSPKYKPRILVCSTQKRHHARFFVKKPQDGDRNGNPKPGTIVEKVVTHPFEYDFYLVSHPSLQGVSVPIHYTVLYDEIKMPPDQFQSLCYNLCYVYARATTAVSLVPPVYYAHLLSNMARFQDDTAKDDASSVASGATEPEEVKPLRKVAPSLKTKMWFM
InterPro domains: - IPR003100: PAZ domain (domain) [215-356]
- IPR045246: Argonaute-like, PIWI domain (domain) [378-802]
- IPR032474: Protein argonaute, N-terminal (domain) [26-155]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [492-804]
- IPR032472: Argonaute linker 2 domain (domain) [360-406]
- IPR032473: Protein argonaute, Mid domain (domain) [412-495]
- IPR003165: Piwi domain (domain) [506-806]
- IPR014811: Argonaute, linker 1 domain (domain) [164-214]
- IPR036085: PAZ domain superfamily (homologous_superfamily) [209-373]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [576-842]
Interaction partners: - RITS complex subunit 3
- Chromodomain protein Chp1
- Uncharacterized protein
- Argonaute binding protein 1
- DNA-directed RNA polymerase subunit
- Mediator of RNA polymerase II transcription subunit 1
- Argonaute binding protein 2
- Histone-lysine N-methyltransferase
- Chromodomain protein Swi6
- RNA-dependent RNA polymerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)