Protein: Ubiquitin-conjugating enzyme E2 2 (O74201)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation
Subcellular location: Cytoplasm. Nucleus
Sequence: MSTPARRRLMRDFKRMQQDPPSGVSASPLPDNVMKWNAVIIGPSDTPFEDGTFRLLLSFDEQYPNKPPQVKFISEMFHPNVYASGELCLDILQNRWSPTYDVSSILTSVQSLLNDPNISSPANVEAANLYKDHRSLYVKRVRETVENSWNDDDDEEEEEEDEDEAEDEDDDDDDNIDED
InterPro domains: - IPR016135: Ubiquitin-conjugating enzyme/RWD-like (homologous_superfamily) [1-166]
- IPR000608: Ubiquitin-conjugating (UBC), catalytic core domain (domain) [4-150]
- IPR050113: Ubiquitin-conjugating enzyme (family) [3-149]
- IPR023313: Ubiquitin-conjugating enzyme, active site (active_site) [77-92]
Interaction partners: - Postreplication repair E3 ubiquitin-protein ligase RAD18
- E3 ubiquitin-protein ligase BRE1
- Ubiquitin-activating enzyme E1 1
- Nucleoporin NSP1
- E3 ubiquitin-protein ligase
- Polyubiquitin
- Ubiquitin-ribosomal protein eS31 fusion protein
- E2 ubiquitin-conjugating protein
- HECT-type E3 ubiquitin transferase
- DNA polymerase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0104004 (cellular response to environmental stimulus), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0071478 (cellular response to radiation), GO:0009416 (response to light stimulus), GO:0006974 (cellular response to DNA damage stimulus), GO:0009411 (response to UV), GO:0071482 (cellular response to light stimulus), GO:0034644 (cellular response to UV)
Cellular Component (CC): GO:0005575 (cellular component), GO:0009987 (cellular process), GO:0040007 (growth), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0104004 (cellular response to environmental stimulus), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0071478 (cellular response to radiation), GO:0009416 (response to light stimulus), GO:0006974 (cellular response to DNA damage stimulus), GO:0009411 (response to UV), GO:0071482 (cellular response to light stimulus), GO:0034644 (cellular response to UV)