Protein: Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (S4S3R8)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
InterPro domains: - IPR045318: Histone-lysine N-methyltransferase EZH1/2-like (family) [72-702]
- IPR021654: Histone-lysine N-methyltransferase EZH1/EZH2 (family) [39-68]
- IPR041343: Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain (domain) [119-210]
- IPR041355: Pre-SET CXC domain (domain) [520-551]
- IPR026489: CXC domain (domain) [464-566]
- IPR046341: SET domain superfamily (homologous_superfamily) [476-697]
- IPR001005: SANT/Myb domain (domain) [120-437]
- IPR048358: EZH1/2, MCSS domain (domain) [218-270]
- IPR033467: Tesmin/TSO1-like CXC domain (domain) [516-553]
- IPR044439: EZH2, SET domain (domain) [570-689]
- IPR001214: SET domain (domain) [573-694]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0003682 (chromatin binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:1990841 (promoter-specific chromatin binding), GO:0008276 (protein methyltransferase activity), GO:0003676 (nucleic acid binding), GO:0031490 (chromatin DNA binding), GO:0008168 (methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0003677 (DNA binding), GO:0001221 (transcription coregulator binding), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0001222 (transcription corepressor binding), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0042752 (regulation of circadian rhythm), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0090068 (positive regulation of cell cycle process), GO:0044093 (positive regulation of molecular function), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0010718 (positive regulation of epithelial to mesenchymal transition), GO:0031324 (negative regulation of cellular metabolic process), GO:0045787 (positive regulation of cell cycle), GO:0051726 (regulation of cell cycle), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009890 (negative regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0048385 (regulation of retinoic acid receptor signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:1901989 (positive regulation of cell cycle phase transition), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051338 (regulation of transferase activity), GO:0043085 (positive regulation of catalytic activity), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0010717 (regulation of epithelial to mesenchymal transition), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902808 (positive regulation of cell cycle G1/S phase transition), GO:0051276 (chromosome organization), GO:0051345 (positive regulation of hydrolase activity), GO:0019220 (regulation of phosphate metabolic process), GO:0040029 (epigenetic regulation of gene expression), GO:0043087 (regulation of GTPase activity), GO:0006338 (chromatin remodeling), GO:0043549 (regulation of kinase activity), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0043410 (positive regulation of MAPK cascade), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0031401 (positive regulation of protein modification process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:0031507 (heterochromatin formation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0043547 (positive regulation of GTPase activity), GO:0045859 (regulation of protein kinase activity), GO:0070828 (heterochromatin organization), GO:0032200 (telomere organization), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0043406 (positive regulation of MAP kinase activity), GO:0001934 (positive regulation of protein phosphorylation), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0031509 (subtelomeric heterochromatin formation), GO:0045860 (positive regulation of protein kinase activity), GO:0140719 (constitutive heterochromatin formation), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:0043405 (regulation of MAP kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)