Protein: cAMP-dependent protein kinase type I-beta regulatory subunit (P81377)
Organism: Rattus norvegicus (Rat)
Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Subcellular location: Cell membrane {ECO:0000250}.
Sequence: MASPSCFHSEDEDSLKGCEMYVQKHGIQQVLKECIVHLCVAKPDRPLRFLREHFEKLEKEENRQILARQKSNSQCDSHDEEISPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFSHLDDNERSDIFDAMFPVTHIDGETVIQQGNEGDNFYVIDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV
InterPro domains: - IPR050503: cAMP-dependent protein kinase regulatory subunit-like (family) [35-381]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [104-381]
- IPR012198: cAMP-dependent protein kinase regulatory subunit (family) [5-381]
- IPR000595: Cyclic nucleotide-binding domain (domain) [137-376]
- IPR018488: Cyclic nucleotide-binding, conserved site (conserved_site) [164-341]
- IPR003117: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain (domain) [25-62]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [119-372]
- IPR042818: RIbeta, dimerization/docking domain (domain) [10-64]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008603 (cAMP-dependent protein kinase regulator activity), GO:0097367 (carbohydrate derivative binding), GO:0036094 (small molecule binding), GO:0005515 (protein binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0019899 (enzyme binding), GO:0032553 (ribonucleotide binding), GO:0051018 (protein kinase A binding), GO:0034236 (protein kinase A catalytic subunit binding), GO:0019900 (kinase binding), GO:0030552 (cAMP binding), GO:0030551 (cyclic nucleotide binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0019901 (protein kinase binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:2000241 (regulation of reproductive process), GO:0051321 (meiotic cell cycle), GO:2000242 (negative regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0065009 (regulation of molecular function), GO:1903046 (meiotic cell cycle process), GO:0032504 (multicellular organism reproduction), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0051726 (regulation of cell cycle), GO:0007276 (gamete generation), GO:0050790 (regulation of catalytic activity), GO:0140013 (meiotic nuclear division), GO:0051129 (negative regulation of cellular component organization), GO:0051445 (regulation of meiotic cell cycle), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0045786 (negative regulation of cell cycle), GO:0051447 (negative regulation of meiotic cell cycle), GO:0007143 (female meiotic nuclear division), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0010639 (negative regulation of organelle organization), GO:0007292 (female gamete generation), GO:0051246 (regulation of protein metabolic process), GO:0040020 (regulation of meiotic nuclear division), GO:0033043 (regulation of organelle organization), GO:0051338 (regulation of transferase activity), GO:0045835 (negative regulation of meiotic nuclear division), GO:0006996 (organelle organization), GO:0051174 (regulation of phosphorus metabolic process), GO:0051783 (regulation of nuclear division), GO:0051784 (negative regulation of nuclear division), GO:0043549 (regulation of kinase activity), GO:0031399 (regulation of protein modification process), GO:0048285 (organelle fission), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0000280 (nuclear division), GO:0045859 (regulation of protein kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0005952 (cAMP-dependent protein kinase complex), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:1902911 (protein kinase complex), GO:1902554 (serine/threonine protein kinase complex)