Protein: Sorting nexin-25 (Q3ZT31)
Organism: Mus musculus (Mouse)
Function: May be involved in several stages of intracellular trafficking.
Subcellular location: Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Sequence: MDRVLRDVFDYSYRDYILSWYGNLSRDDGQLYHLLLDDFWEIVKQIRQRLSHVDVVKVVCNDIVKALLTHFCDLKAATARHEEQPRPFVLHACLKDSHDEVRFLQTCSQVLVLCLLPSKDIQSLSLRTMLAEILTTKVLKPVVELLSNPDYINQMLLRQLEYREQMSEHHKRAYTYAPSYEDFIKLINSNSDVDFLKQLRYQIVVEIIQATTISSFPQLKRHKGKESAAMKTDLLRARNMKRYINQLTVAKKQCEKRIRILGGPAYDQQEDGASDEGEGPQSQKILQFEDIMTNPFYRERFGTYMERIDKRALVGFWESAEHLKNANKSEIPQLVSEMYQNFFVESKEISVEKSLYKEIQQCLVGNRGIEVFSKIQADVSEVLRERYYPSFLVSDLYEKLMREEEEEEPDAQLASEKDELGSGGEAGEEAVEGTSGVSDPASFAVIKLRELNEKLEYKRQALSSIQNAPKPDKKIISKLKDEILLIEKECTALQLHMARTDWWCENLGLWRASITSAEVTEENGEQMPCYFVRVNLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLGKSRNQLNAFLQNLLSDERLFQSEALYAFLSPSPDYLKVIDVQGKKTSFSLSSFLEKLPRDFFSHQEEEIEEDSDLSDYGDDVDGKKDSLAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRDTVSWISSEQMLVYYISAFRDAFWPNGKLAPPTRIRSVAQSQETKQRAQQKLLENIPDTLQSLVGQQNARHGIIKIFKALQETKANKHLLYVLMELLLTELCPELRAHLDQFKAGQV
InterPro domains: - IPR044926: RGS, subdomain 2 (homologous_superfamily) [280-414]
- IPR016137: RGS domain (domain) [287-401]
- IPR001683: Phox homology (domain) [508-628]
- IPR036305: RGS domain superfamily (homologous_superfamily) [280-403]
- IPR013937: Sorting nexin, C-terminal (domain) [701-806]
- IPR037899: SNX25, PX domain (domain) [502-624]
- IPR003114: Phox-associated domain (domain) [1-164]
- IPR036871: PX domain superfamily (homologous_superfamily) [495-632]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0009056 (catabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0009892 (negative regulation of metabolic process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009966 (regulation of signal transduction), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043112 (receptor metabolic process), GO:0009057 (macromolecule catabolic process), GO:0090101 (negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0051246 (regulation of protein metabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0010563 (negative regulation of phosphorus metabolic process), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0051174 (regulation of phosphorus metabolic process), GO:0032801 (receptor catabolic process), GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway), GO:0031399 (regulation of protein modification process), GO:0031400 (negative regulation of protein modification process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway), GO:0019220 (regulation of phosphate metabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0060393 (regulation of pathway-restricted SMAD protein phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0001750 (photoreceptor outer segment), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0097730 (non-motile cilium), GO:0005634 (nucleus), GO:0097733 (photoreceptor cell cilium), GO:0097731 (9+0 non-motile cilium)