Protein: Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide (GMAP)] (P47212)
Organism: Mus musculus (Mouse)
Function: Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3 (By similarity). This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P22466}.
Sequence: MARGSVILLGWLLLVVTLSATLGLGMPAKEKRGWTLNSAGYLLGPHAIDNHRSFSDKHGLTGKRELQLEVEERRPGSVDVPLPESNIVRTIMEFLSFLHLKEAGALDSLPGIPLATSSEDLEKS
InterPro domains: - IPR008174: Galanin (domain) [33-60]
- IPR013068: Galanin message associated peptide (GMAP) (domain) [62-123]
- IPR008175: Galanin precursor (family) [1-124]
Interaction partners: - Galanin receptor type 1
- Galanin receptor type 2
- Galanin receptor type 3
- Somatostatin
- Pro-neuropeptide Y
- Pro-opiomelanocortin
- Protachykinin-1
- Prepronociceptin
- Pro-MCH
- Neurotensin/neuromedin N
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0001664 (G protein-coupled receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0002683 (negative regulation of immune system process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0002695 (negative regulation of leukocyte activation), GO:0050776 (regulation of immune response), GO:0050866 (negative regulation of cell activation), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0032350 (regulation of hormone metabolic process), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007631 (feeding behavior), GO:0071495 (cellular response to endogenous stimulus), GO:0031323 (regulation of cellular metabolic process), GO:0002694 (regulation of leukocyte activation), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0010817 (regulation of hormone levels), GO:0050865 (regulation of cell activation), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0035902 (response to immobilization stress), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0010243 (response to organonitrogen compound), GO:0090087 (regulation of peptide transport), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0070664 (negative regulation of leukocyte proliferation), GO:0043627 (response to estrogen), GO:0019216 (regulation of lipid metabolic process), GO:0070663 (regulation of leukocyte proliferation), GO:0051250 (negative regulation of lymphocyte activation), GO:0051249 (regulation of lymphocyte activation), GO:0019218 (regulation of steroid metabolic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0050670 (regulation of lymphocyte proliferation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:0032868 (response to insulin), GO:0032945 (negative regulation of mononuclear cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)