wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: G/U mismatch-specific DNA glycosylase (EC 3.2.2.28) (Double-strand-specific uracil glycosylase) (Mismatch-specific uracil DNA-glycosylase) (MUG) (P0A9H1)
Organism: Escherichia coli (strain K12)
Function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MVEDILAPGLRVVFCGINPGLSSAGTGFPFAHPANRFWKVIYQAGFTDRQLKPQEAQHLLDYRCGVTKLVDRPTVQANEVSKQELHAGGRKLIEKIEDYQPQALAILGKQAYEQGFSQRGAQWGKQTLTIGSTQIWVLPNPSGLSRVSLEKLVEAYRELDQALVVRGR
InterPro domains: - IPR023502: G/U mismatch-specific DNA glycosylase MUG, bacterial (family) [1-168]
- IPR015637: Uracil DNA glycosylase family 2 (family) [2-161]
- IPR005122: Uracil-DNA glycosylase-like (domain) [6-158]
- IPR036895: Uracil-DNA glycosylase-like domain superfamily (homologous_superfamily) [1-168]
Interaction partners: - Exodeoxyribonuclease III
- Endonuclease III lyase)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0016799 (hydrolase activity, hydrolyzing N-glycosyl compounds), GO:0019104 (DNA N-glycosylase activity), GO:0097506 (deaminated base DNA N-glycosylase activity), GO:0004844 (uracil DNA N-glycosylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Sperm protamine R3 isoform 1 (P83266)
Organism: Hydrolagus colliei (Spotted ratfish) (Chimaera colliei)
Function: Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
Subcellular location: Nucleus {ECO:0000269|PubMed:8875866}. Chromosome {ECO:0000269|PubMed:8875866}.
Sequence: ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKQHGFLKQPPRFRP
InterPro domains: - IPR012601: Spermatozal protamine type (family) [1-48]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007059 (chromosome segregation), GO:0044085 (cellular component biogenesis), GO:1903047 (mitotic cell cycle process), GO:0016043 (cellular component organization), GO:0000278 (mitotic cell cycle), GO:0007283 (spermatogenesis), GO:0098813 (nuclear chromosome segregation), GO:0007076 (mitotic chromosome condensation), GO:0140014 (mitotic nuclear division), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0000070 (mitotic sister chromatid segregation), GO:0022607 (cellular component assembly), GO:0006338 (chromatin remodeling), GO:0000819 (sister chromatid segregation), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0048285 (organelle fission), GO:0006334 (nucleosome assembly), GO:0051276 (chromosome organization), GO:0030261 (chromosome condensation), GO:0000280 (nuclear division), GO:0034728 (nucleosome organization), GO:0065004 (protein-DNA complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0044815 (DNA packaging complex), GO:0000785 (chromatin), GO:0000786 (nucleosome), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)
Protein: AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) (Q9DB50)
Organism: Mus musculus (Mouse)
Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).
Subcellular location: Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Sequence: MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEDAKEAETPRSVLEEIGLT
InterPro domains: - IPR011012: Longin-like domain superfamily (homologous_superfamily) [2-139]
- IPR000804: Clathrin adaptor complex, small chain (conserved_site) [56-66]
- IPR022775: AP complex, mu/sigma subunit (domain) [1-140]
- IPR044733: AP-1 complex subunit sigma (family) [2-144]
- IPR016635: Adaptor protein complex, sigma subunit (family) [1-151]
Interaction partners: - AP-1 complex subunit gamma-1
- AP-1 complex subunit mu-1
- AP-1 complex subunit beta-1
- AP-1 complex subunit gamma-like 2
- AP-1 complex subunit mu-2
- AP-1 complex subunit sigma-1A
- AP-1 complex subunit sigma-3
- AP-4 complex subunit mu-1
- AP-2 complex subunit beta
- AP-4 complex subunit epsilon-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0046907 (intracellular transport), GO:0051649 (establishment of localization in cell), GO:0006810 (transport), GO:0016482 (cytosolic transport), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0042147 (retrograde transport, endosome to Golgi)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098793 (presynapse), GO:0150034 (distal axon), GO:0044306 (neuron projection terminus), GO:0042995 (cell projection), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0043195 (terminal bouton), GO:0043005 (neuron projection), GO:0030424 (axon)
Protein: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) (Q9Y765)
Organism: Candida albicans (Yeast)
Function: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
Sequence: MTDSKYDYSDITPVDINTEEPQICQILYDEDYKQIMGLLLALMKAEEYSERALHITELGINELASHYTIWIYRFNILKNLPNRNLYDELDWCEEIALDNEKNYQIWNYRQLIIGQIMELNNNDFDPYREFPILEAMLSSDPKNHHVWSYRKWLVDTFDLHNDAKELSFVDKVIDTDLKNNSAWSHRFFLLFSKKHLATDNTIDEELNYVKDKIVKCPQNPSTWNYLLGIHERFDRSITQLEEFSLQFVDLEKDQVTSSFALETLAKIYTQQKKYNESRTVYDLLKSKYDPIRSNFWDYQISKLTSV
InterPro domains: - IPR002088: Protein prenyltransferase, alpha subunit (repeat) [48-235]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0097354 (prenylation), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051604 (protein maturation), GO:0043412 (macromolecule modification), GO:0018342 (protein prenylation), GO:0010467 (gene expression), GO:0018344 (protein geranylgeranylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex)
Protein: KAR9-domain-containing protein (Q5BBH9)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MRAIFTTSSHPSAPAPDTSTSATTSQGSPPPPPPPLVSVSSPDESATPRRIKSKASLRSTRSIGSSLLHEDDGDDAQSEKSLIRPNILRRLSPGLAARVKLLDGSSKTATSPRNPGAVGRIPEEQIKELDSLHKVQSIEVERKGRAWSGISFANKTQKQQVQREPLPQSGVPEPPVAESTPGSGQDATSDRLETKEEKVENTPTTMSVVEPAPAPLGPEISDPNIEDQTDGPTDYEKYIQKTSELEAEANGAPRPPPKDSPPIQSSASSNTQSYFNPHGLHRTSSIYSSTNSIFSFSRSSFSNQISQLTSIALPQPSSLEASIASISNAPAAVKALTGAAEQIQIWIRKASNVLNGLDAEDDVVWAAAAGREGLDGVDKAITKFESLVNVYVKAIEDVQLREDIANVSTDGLETIVTQMDSILQSWANIKSRLRAVKEQVELAMEWEELWNSVLGDVGEEVEELEGLVFEMEAKRHFNLANEDSTGLDINELETIVEETPSSGRFLNKRSSMGSLYPAPPALDRPIIQTPQDDTNHSNLVELFARLQPLRASLDFLPMRLSMFQSRAEKVFPSACTELMERREKLEKDYKNLQADAETLRKELEEDRWIMVFRNAGSQAQKMFESVERSISKLQEGLETGMHLHNPAGMTNRIESYEAKKQHYVPAIDRVLTITQKGVKDRLTVNGEILRLLANMESQVNALRASIKVMDSSLEDIQDLRSQHMRDSISTVLTIDSPATGSLADTPGSSPASSVVMTPANKSSRRGSSVGSAARTSTGRRVSGLPQLASNLTGRKPSNPKATPKTTLTAPSPTPAARKPAQPAQPALSPALLNRPRWNTSTNTNDLDVGHKYKPWTPSLRKQTAPSRGTRPSSTIPPRDPSTSPVPPTARSASRISSRLGLRSPGRTASPSPSPSILDPPPYSKLRRPAGTENMSNTPRSRQSFAGTSFNRSVSQEQGRSDSPTKAARPGTALGHSGSRRISLLPLPRNRNKDNFPSTRSKLSERPPWRG
InterPro domains: - IPR013889: Karyogamy protein, KAR9 (family) [88-1009]
Interaction partners: - Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030428 (cell septum), GO:0031975 (envelope), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005881 (cytoplasmic microtubule), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005634 (nucleus)
Protein: GH16244p (Q9W2R2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
Sequence: MSCEVHYDAASRTWFGPRGKDFYGPEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAFKRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVENYHIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLNDEDSITAAAYVPCPKLHGDHTAFIVCSSGTTGMPKGVTRSHRSLLCNCKNPNTYTRDSVLLSFSPLYWISGTIILLASLLNGCRRIITNRPYSVEYLLQLVARHKVTFLFLASHQIALLSKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRRMYELIGNQRFVVGYGLSEMGGLSKNVGGPVGCEGKVMRNVELRVLDKLKMPLGINEVGIIYARLRFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFILRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEHHLSGAYHIRGGVYFIDSLPKTPNDKLQRRKVLGLVQQLELKAE
InterPro domains: - IPR042099: ANL, N-terminal domain (homologous_superfamily) [20-435]
- IPR000873: AMP-dependent synthetase/ligase domain (domain) [48-396]
- IPR045851: AMP-binding enzyme, C-terminal domain superfamily (homologous_superfamily) [436-540]
- IPR020845: AMP-binding, conserved site (conserved_site) [195-206]
- IPR025110: AMP-binding enzyme, C-terminal domain (domain) [448-527]
Interaction partners: - Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0015645 (fatty acid ligase activity), GO:0016877 (ligase activity, forming carbon-sulfur bonds), GO:0016878 (acid-thiol ligase activity), GO:0016405 (CoA-ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)
Protein: Keratin-associated protein 23-1 (A1A580)
Organism: Homo sapiens (Human)
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Sequence: MSYNCCCGNFSSHSCEGYLCYSGYSRGGSSYPSNLVYSTEPLISQHLPAGFLSLQGLSGDLLGNP
InterPro domains: - IPR007951: Keratin-associated protein, PMG type (family) [1-41]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0001775 (cell activation), GO:0009566 (fertilization), GO:0007343 (egg activation), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: SWI/SNF complex subunit SWI3C (AtSWI3C) (Transcription regulatory protein SWI3C) (Q9XI07)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
Sequence: MPASEDRRGKWKRKKRGGLSAARKPKQEEEDMEEEDEENNNNNNEEMDDVENADELQQNGGATPDPGLGIGEVVEDSGSRISDFPAVVKRVVIRPHASVMAVVAAERAGLIGETRGQGSLPALENISFGQLQALSTVPADSLDLERSDGSSSAYVISPPPIMDGEGVVKRFGDLVHVLPMHSDWFAPNTVDRLERQVVPQFFSGKSPNHTPESYMEFRNAIVSKYVENPEKTLTISDCQGLVDGVDIEDFARVFRFLDHWGIINYCATAQSHPGPLRDVSDVREDTNGEVNVPSAALTSIDSLIKFDKPNCRHKGGEVYSSLPSLDGDSPDLDIRIREHLCDSHCNHCSRPLPTVYFQSQKKGDILLCCDCFHHGRFVVGHSCLDFVRVDPMKFYGDQDGDNWTDQETLLLLEAVELYNENWVQIADHVGSKSKAQCILHFLRLPVEDGLLDNVEVSGVTNTENPTNGYDHKGTDSNGDLPGYSEQGSDTEIKLPFVKSPNPVMALVAFLASAVGPRVAASCAHESLSVLSEDDRMKSEGMQGKEASLLDGENQQQDGAHKTSSQNGAEAQTPLPQDKVMAAFRAGLSAAATKAKLFADHEEREIQRLSANIVNHQLKRMELKLKQFAEIETLLMKECEQVEKTRQRFSAERARMLSARFGSPGGISPQTNNLQGMSLSTGGNNINSLMHQQHQQQQASATSQPSIIPGFSNNPQVQAQMHFMARQQQQQQQQQQQQQQAFSFGPRLPLNAIQTNAGSTASPNVMFGNNQLNNPAAAGAASINQPSFSHPMVRSSTGSGSGSGLGLN
InterPro domains: - IPR032451: SMARCC, C-terminal (domain) [585-658]
- IPR000433: Zinc finger, ZZ-type (domain) [340-394]
- IPR001005: SANT/Myb domain (domain) [399-447]
- IPR007526: SWIRM domain (domain) [176-274]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [175-452]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [182-269]
- IPR017884: SANT domain (domain) [398-449]
Interaction partners: - Chromatin structure-remodeling complex protein BSH
- SWI/SNF complex component SNF12 homolog
- At3g01890
- Actin-related protein 4
- Armadillo repeat-containing protein LFR
- SWI/SNF complex subunit SWI3B
- Chromatin structure-remodeling complex protein SYD
- At1g76380
- DNA-binding bromodomain-containing protein
- At1g20670
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0080134 (regulation of response to stress), GO:0031347 (regulation of defense response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC 4.1.2.55) (F9VPG1)
Organism: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
Function: Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal).
Sequence: MDIVTPILTPFTKEGKIDVEKLKAHAKFLIDNGIDLLFVNGTTGLGPALSKEEKLTTLKTIYDVTNKVIFQVGSLNINDVIDLVKASKDFDIVGIASYPPFYFPRLPEKFLLKYFTTIANYSPHSLYIYNYPLATGYDISAKIVYQMKDLITGLKDTNQDLSHSLEYKILMPNLKVYNGSDSLVFYSLTSLDGSVTAASNYLPHVMKKMKEHITSGQVSKAIELQKLINKALDISRKYGQLSAIYYLVKEFLGYDVGYPRGPIFPLEEDEVKALLSEIQPVKKEIERAVS
InterPro domains: - IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-290]
- IPR002220: DapA-like (family) [1-289]
- IPR053415: Entner-Doudoroff pathway aldolase (family) [1-287]
Interaction partners: - 2-dehydro-3-deoxygluconokinase
- Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase
- gluconate dehydratase
- gluconate dehydratase
- Indolepyruvate--methylviologen oxidoreductase subunit a
- Indolepyruvate--methylviologen oxidoreductase subunit b
- Indolepyruvate--methylviologen oxidoreductase subunit c
- Phosphoglucosamine/phosphogalactosamine mutase
- Triosephosphate isomerase
- Pyruvate kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016832 (aldehyde-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0005996 (monosaccharide metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0006082 (organic acid metabolic process), GO:0019321 (pentose metabolic process), GO:0046365 (monosaccharide catabolic process), GO:0016052 (carbohydrate catabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0019566 (arabinose metabolic process), GO:0019323 (pentose catabolic process), GO:0019568 (arabinose catabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006103 (2-oxoglutarate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)