Protein: Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) (Q03206)
Organism: Caenorhabditis elegans
Function: Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. May regulate these 2 processes by activating pak-1 and/or max-2. Plays a role, probably via mig-10, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1. Regulates mig-10 asymmetric distribution in HSN neurons. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required together with mig-2 to inhibit growth cone filopodial protrusion mediated by netrin guidance cue unc-6 and its receptors unc-5 and unc-40. Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and, together with mig-2, by restricting plus-end microtubule accumulation in the growth cone. Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration. During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2. Furthermore, plays a role in distal tip cell polarity and migration by negatively regulating the unc-6/Netrin receptor unc-5. May be involved in signal transduction during cell migration. May be involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27415421, ECO:0000269|PubMed:8824291}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:27415421, ECO:0000269|PubMed:8824291}. Note=Co-localizes with pak-1 and cdc-42 at hypodermal cell boundaries during embryo elongation. {ECO:0000269|PubMed:8824291}.
Sequence: MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGRPINLGLWDTAGQEDYDRLRPLSYPQTDVFLVCFALNNPASFENVRAKWYPEVSHHCPNTPIILVGTKADLREDRDTVERLRERRLQPVSQTQGYVMAKEIKAVKYLECSALTQRGLKQVFDEAIRAVLTPPQRAKKSKCTVL
InterPro domains: - IPR001806: Small GTPase (family) [1-191]
- IPR003578: Small GTPase Rho (family) [3-189]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-182]
- IPR005225: Small GTP-binding domain (domain) [1-156]
Interaction partners: - CED-5
- CRAL-TRIO domain-containing protein
- Serine/threonine-protein kinase pak-1
- Cell death abnormality protein 12
- DH domain-containing protein
- Serine/threonine-protein kinase max-2
- Wiskott-Aldrich syndrome protein family member
- Cell death abnormality protein 2
- Probable rho GDP-dissociation inhibitor
- Netrin receptor unc-40
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097367 (carbohydrate derivative binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0017076 (purine nucleotide binding), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0016049 (cell growth), GO:0030029 (actin filament-based process), GO:0032989 (cellular component morphogenesis), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0030036 (actin cytoskeleton organization), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0030030 (cell projection organization), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0006996 (organelle organization), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0030182 (neuron differentiation), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:1902284 (neuron projection extension involved in neuron projection guidance), GO:0007010 (cytoskeleton organization), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0048675 (axon extension), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0008045 (motor neuron axon guidance), GO:0033563 (dorsal/ventral axon guidance), GO:0007409 (axonogenesis), GO:0048846 (axon extension involved in axon guidance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0055037 (recycling endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097708 (intracellular vesicle), GO:0015630 (microtubule cytoskeleton)