Protein: Tweek, isoform J (X2JA38)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
Sequence: MEALEVEDTSDDSLPMGFPEVGTWNSTHNVSLNDMNLDARMIWLLASLLTTITWVTYITFYNSRVIGMLITKIANRWFIKGAYFKIGSVALNPLAGKIMFRDFVYITYDYTVRAQDGYFIFRWWRSYVPKDVSEDLSHSDTRLSVQLNGYELHIYNRSDLYDTLEKTFGLEPSLLIPTDAASNEERNKLKEHHMNLENARQSQRIQNVKNSEAMQATTWRDLIPVIKIDVCSGRFVFGNRLTPTTLSISVEEAHCTYSTKPAVCRLDHFMHFVKAKVENAKVLFCPSPKYTGLIDEPPRYMGEGFVVMMSNQMDLYFYMDEPGVVPEHPVQIVLPNGDVVEPSPPVWGINARCLRGTDFSYGPWADRQRDHLYRYFYPSDWKEAEVTPTPQPGELRSYQSFDVTLCVLNEATIDILFSKEKETNAMHITVGPASYVEMTIPWVTQPDGYTSKIQGQLFHVEATTSLQYRSLAEFESLEYKVRIHYPTKWNAPQDWSISLSGCKTSAFIVYKHKCFFQDLIEDWANKARPDILSFVPYTCNFSIRLHEFEILMLCNEYNWIDCSSANQENNHLAFCGDVFEMSFALPFDDFLPKTVTLKFWIHGEGLDLSLYVPEVSSVRPIVLAIDENARLLTREGKLIRRPELYSKKWRKICQRSAGWIDCWAVPILALSIQYVYHPVPPLGPDPQADITTPEKEEILLSPMRIPKVRKSPVSSWQQPPEQYSKFDPGTLAADHVTVELEIGSSVLMAYGNVLRNFISLKENIFGEDQNFTDMEQSNVNMKEPGVAQVNPKDQLLAKEKELANKSISETQPPEEKRKPFDPRLYRPLEVMVSVIVHDIQAHVMKNCNEDDPPCPVVLIERFGFEMNKKYHETTLQVLVSPSYLLTSDCLQRSQREQHINQGHLMLSAVQVRGHAMFSNEGCALDEDTLEYSWLVEVQLGKLTGKLTLPQLVNVVTGLETLILLAIDPENCLKSPKTVRNCHHGVPSNLCPQTKEEKKYKCPSSEDIKYKMTRVSVDAVDVYLIESGTALHAWISPIRLANCNLHGQRVKSGISGLLPSILLRLFMLHTTNSTFNTNTTGSNRSGKLRRADQDSLKSQDAGGSHYASHGKTGKRSSNSFSRRDSREEATRKLRGSFSETHTKRTPETEITENWVEVGCTSLGPILLEGASALPIPDHELHLVQHNFLREHDAKFKRLWFLWSNNGSALSSGSEISRCGCIGGCAFFGSNRNGQKFFKPTAQDAHDNYNIARYFIINNNKDFGFGESILHQGQLVFHTPPYSLHCVSLYDTADFNGKGRLYRPAGDLRNGSLKKTDLCSLPDGTKFKIGASGTTGVEKPEPNCRNKSRESIGSPNTLERRTKRYPCTRQTSVDVPYARLLDSPSKKLQLQHEASAGDAGSSHRRGSDSNRLRVSPPKTSISDSRLTGDVLDDETEIPDEMSHSAPHSHPLEFEIADIALHVQGLGGDQLPREVQRTISLTSENPSEMFFSAEEDISNVLSQRGSMKQRNSVNSGSVVLSGKKRFSSDLSIGAQNDNGSHTLPTYRSDLEIHAPDGNKTLPKRPQSTTELNEDARRIHGLATPIRKITNISSRPEYRHFVHDADSRGSSSGTPSLSSNSFISAMSSQEDVALVNLHQQVNRPIIDSPLLMASYLNHLSQVKCFNWNGCSFPLGPDVFSTPLFSENEDGGLTYIGSKMLPHFDLYSCWREIKVVPRYENATGSNSSATFMGGPKSHPWDPSVLLKEEESDKTTNGFDDGEFMSLQAEGGAVCTSVVARLKGQLNVFLTPLLLEGLQRMVEAAVPTIQSMHLLSVVNFIHTSCIAKVNNDNILKRDQSLSYWSQVHSNSKRSTTERHLQGPGDSFLSDVYEESISTKTQGLIVLPKVSITMLQSSIVEEIISVAALDNVQDLSCVSLLTFYMEGISTKFHMGKTTRASMHNVYIQQTVQSGSSNKKGGIMKGTRALLAHLSSQTRPDNVQGEPILIETSEKQLEEVVITLDIGRAHAQLRRLKTEGQSCTQDSPIIVTAIPEHKSKVLFECLKMPESTGIESIGYIMFECGLEGVGVKIVKRSHFEKSENSKEELAEMAGAGAGGGASAGGFNLNDLVGQGEGAAGSGDGGATSKAEAAWRLITKKPPTPKTPKEKFQPASDSNISAETSGAEKGKSTPKPPDEDVEKGTSPANAQTGAQKPSAGAGTNTKDNYDKVLSNVKETDKTSSCVIELKAVWFNFAAPPCVPITRKIDLTRLDWNLLSTASPAITAWMNPSNRLAMKIVSLMKALHTRQTAVAACLMAEAMDNEKIQRNPKIKKSRYANNYTLLSKTLQEDPSCQLCYIMQKLVLDEGVQRIETIFKQHDVPHLNTLRQGIIVLSRQWKNTLYNPILFEHQYKNKLSRPINVTFSFPQNEEDAENDECEGDVEMGAFAGVGENPEESENALLLGQTQHHRTHIGATYGHEGANHGTASQRSTSTSPNIHHPRRGLNKVHSKASNYSHGNSSRSSIQMLPIISGQVPEFEYGALQEGSLSSTNSVNKSWLGTENHKEDLYFWMAKQQDNKKKHFTEKEHARPAPPKMTEHAGQTRSGIMQDSIKLLDAHLIFEPLLTCLGVMPQQMINKFSNADISSLENFGTNLSLIGTFDSIRVDIVVSEAGDKKNSAQKPAKLNKKSNGGRASIMMDTPLFLCERVGVELEVLKMSDGMVDQARQNVIYMSRRQLKKHTSTVINFSLNVRFISQQVNMPLLRLLHQICNMYQNVKDAQNEFHDQPELSKKSQTKDECSLASEPTDIVPFNSMSERYNHAENYSDERYDKFNETMPTMLARPRPGGLAPIIQLTPSPNAKNRPQSFAQKLRSTGKSVKGKLGYTNLNESSSSPLRDSPTMSLHEHNILKMSTESKASLNGACATSVSGDYQNTLTKAGMPTMAPMLETPNCWKTIYHLLELYGTMPETKTVVQRSSLNEHKSKSAGFAHDDDDLASAPTPLPQHREMLLVDASSQERTRLIVFGVAKIHKTRLLATLSGLKLESEITTLNSTATWRKKARPVSLECSLTGQVGRAMIVLLEGVAPSQQTVVKVTVGKSQTLYSSLSKRGKDKNSGLLSIGAVNIDIPQHPVALHGMMTRSSKQLSSTLQELRVKRNSGRSTMRSHTAEEPESPFHARNSVGASSGTGVASEMRERTVSGGAGAQQQPQQAARRAAHMAQSKTGTAQHQNGLLQPLVMQFNVLLQSLSINAALLPSLQAQYRMNHVSSMGVTGQRAKFVIDLPTHTLSFNTKIQNEMNLPSEACIGLPPVHVLAEYIPDHRQDHTENVEGIVLRQGGYVNASAEIGEFERCLTTDLLNHLVFVQKVFMREINEVLQKVYGGEKPVPLWTEESGDSSGAVQESSLKRILFSINISMKRIQLTATTPCSSAVRFETGILELQLSNRVKNLGDMSNRKLFFKAHIDFNLSLGQIIRNVIFDEAEPEFQQYAFFHTTINLRNAFQDELLNEDKELILLTLKRPLVYVQPIAVDKAILVWLNYKNAYEYWAEKRANLCHEHAQHSLLSQYSGQHQNQNMQNPQVFDRVAFGQIAGSNLSTLFLQLTVEDMGICLPLKQVNTTTFGSRSYQDFDAKGAVVITLENTIISACNSGALVSKGKFQGLCLRFADDFETNLDDWKPNSAEPIMNVCVVSEGTFEVCSRTTAAKKGENAKWLLNVKWQMEGVDIHLDVNIGKQLSSLGHTLTMLTGFEEDETQMESPDSDEGDQSCRDTFVRRRGDFDNLPAFVFDPTIDSKKRSFMMEKEMAEQLKIINDLRTLGASHNTVAHEERRLQELQAICYKYFRRDMIQKWKRPSLRRSLKTYGRSHSYIGSGSSVSGVGVPQTLDNVSYTGRRLDTIASNDEISSLQSTPASCHSRSASLKHTTGGGVIGGGVNALGRVTFTEAMRQTSLPNADTDTETADNELDWRGDITPSEIDVDGTSVEMRRKHGHGQKQPEPNIDFELDIKVLVNSGKCVLHTKDTGEERGYAGGSGAATSGVPASSVKSHKREKSIGNDWGSPTPSRRQRDKSKLRYNANALLADLTIFHIPGLDVKLHYQSKTLAEQLTGDQLPTGRRMGSKRATLCAWMTLQSIPEETIISPHILEFLEQTLEPIPARQSSSVPPTPSHNTGVNLDILPANYVTYASFPVDVIVYFHMQPSTFRFSCLPVSRVECMLQLPSLDIVFSSKRSSEEENSAQPGGHTQPDQQLPTGGLSVTGCLADFNVFIFHPYGGKKTSKETQFSPLSDSERKDSLSINVEFVKFHITRCRKVYIEPLPSSKRSLDQSRAVIRFSTIVDIGSASFKYDMRRLTEILAFPKAWYRRRIVRRLFLGDLSVQQQQQQQQGNGAETPTGCPPATPTPNEDASRAKDNMRLDFDGQPSQQQQQLGHFGAVRHLKNLGKSSSAESSGTPPSEKNQITAWETLVIFAVNFTKLNVQMNIGNVCGNVVWLTKDFQSDGRLSIGSTGYKNMYAGIYLGGSALDAKGGIVGGSFEVNKINKRFHIKEEAGMEPYHTMGLSFMALELRLDYMGTSVLMTRISSFSAAMKDEWRTASQAAATPAHGKDQPRALIFIHGDLTWDQLQIMISKSTTADLLKMYFKLEEFFTQQFKSSKRVFSNLEPRLQDRTASIKRRQQHKKKPANGELVAPPQIHGMIGENTDARHHRHWQKPLAQAVGLVVPSLVTRLPRHGNVLGGTVELRGQNISLACFHGINFKSKSWALFSLRSPSINFATEARQSEDEVLVTQTLTSSLGQTTEVQQQQNHSMAIVSRITRNIIFPPQFKTLNEWFHYAFANSEIDAVDRFPMLECEREIASNSIERTRASGSSSAAKAQEHNHNREVIFALPSLQLHFKTEHKQGPTTPEPSVLCSIAENKPEVLCSFITEFDDHIFVTVDADAFFFLHDLITSYVTEKEKVIGAQSARAASPNLSQKANLKPYLTDEILKEKKGASNTNLTAQGKQTSGSKNSLDPLQGSHTSLANAAANMSGAATTNTTTTTTATTLSPGAAAGGPSTSATNDSVDGKQQQQEGSPPTFDLESFVRDWRHFECQTWHLEPTVRLLSWAGKSIEPYGVDYILNKLGFSHARTTIPKWLQRGFMDPLDKVQALMMLQLLLMVRENKVERDSGASGSGKQQQQNHRPPTN
InterPro domains: - IPR047104: Bridge-like lipid transfer protein family member 1, N-terminal (domain) [38-1072]
- IPR033616: Bridge-like lipid transfer protein family member 1 (family) [29-5131]
- IPR056742: Bridge-like lipid transfer protein family member 1, C-terminal (domain) [3306-5127]
- IPR056741: Bridge-like lipid transfer protein family member 1, middle region (domain) [1770-3299]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0005319 (lipid transporter activity), GO:0005548 (phospholipid transporter activity), GO:0120013 (lipid transfer activity), GO:0120014 (phospholipid transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051649 (establishment of localization in cell), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0051128 (regulation of cellular component organization), GO:0006810 (transport), GO:0030100 (regulation of endocytosis), GO:0036465 (synaptic vesicle recycling), GO:0099504 (synaptic vesicle cycle), GO:0016192 (vesicle-mediated transport), GO:0140238 (presynaptic endocytosis), GO:1903421 (regulation of synaptic vesicle recycling), GO:1900242 (regulation of synaptic vesicle endocytosis), GO:0048488 (synaptic vesicle endocytosis), GO:0006897 (endocytosis), GO:0099003 (vesicle-mediated transport in synapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse), GO:0031594 (neuromuscular junction)