Protein: Forkhead box protein H1 (G3V7Y6)
Organism: Rattus norvegicus (Rat)
Function: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)
Subcellular location: Nucleus
Sequence: MASGWDLASTYSPTTLSPQLVQALAQGYIPCMGPLDNSQLRPPEAESLSKTPKRRKKRYLRHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPYRPPSPPPPSREDFSIKSLLGDPGKASTWPQHPRLAGQSTPAQASTLSKGEEGIGAGPSNVSDKPLWPLSSLPRPTRIEGETSQGEVIRPSPVSSDQGSWPLHLLQDSSDSMGMSRRGSRASLWGQLPTSYLPIYTPNVVMPLATLPPTSCPRCPSSASPAYWSVGTESQGSQDLLCDLDSLFQGVPPNKSIYDVWVSHPRDLAAPAPGWLLSWYSM
InterPro domains: - IPR047511: Forkhead box protein H1, forkhead domain (domain) [64-142]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [50-154]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [63-147]
- IPR001766: Fork head domain (domain) [62-163]
- IPR052327: Activin-responsive transcriptional regulator (family) [23-401]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [108-114]
Interaction partners: - Mothers against decapentaplegic homolog 2
- Mothers against decapentaplegic homolog 4
- Mothers against decapentaplegic homolog 3
- Mothers against decapentaplegic homolog 3
- Mothers against decapentaplegic homolog 3
- Mothers against decapentaplegic homolog 3
- Homeobox protein Nkx-2.5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0070482 (response to oxygen levels), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0009891 (positive regulation of biosynthetic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0071456 (cellular response to hypoxia), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071453 (cellular response to oxygen levels), GO:0071310 (cellular response to organic substance), GO:0048545 (response to steroid hormone), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0036293 (response to decreased oxygen levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1901655 (cellular response to ketone), GO:0071548 (response to dexamethasone), GO:0031960 (response to corticosteroid), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0036294 (cellular response to decreased oxygen levels), GO:0071383 (cellular response to steroid hormone stimulus), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0045893 (positive regulation of DNA-templated transcription), GO:0051384 (response to glucocorticoid), GO:0071384 (cellular response to corticosteroid stimulus), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0071385 (cellular response to glucocorticoid stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)