Protein: Protein bric-a-brac 2 (Q9W0K4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:11973274}.
Sequence: MDMTKQIVDFEIKSELIGEIDQFEASDYTMAPPEEPKMVEESPQLGHLEDQNRKYSPEREVEPTLQDPSEVVDQMQKDTESVGEVKSPEKDVETELVKSKASPMNDQALTPPPRPLTSSEVVGLRDPEHTELRMCLEAKKSRSLPVSPQPQPNLKLAGSALFEFGQRSSPVETKIKTNPETKPPRRKIVPPSGEGQQFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPIIIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAFDDEDEEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQGGESEISERGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQTLEGRNSAMNAVANQRKSPAPTATGHSNGNSGAAMHSPPGGVAVQSALPPHMAAIVPPPPSAMHHHAQQLAAQHQLAHSHAMASALAAAAAGAGAAGAGGAGSGSGSGASAPTGGTGVAGSGAGAAVGSHHDDMEIKPEIAEMIREEERAKMIESGGHGGWMGAAAAATGAASVAADSYQYQLQSMWQKCWNTNQQNLVQQLRFRERGPLKSWRPEAMAEAIFSVLKEGLSLSQAARKFDIPYPTFVLYANRVHNMLGPSLDGGADPRPKARGRPQRILLGMWPEELIRSVIKAVVFRDYREIKEDMSAHQYANGQGHGTYIGGGTTTNGYHSAAAAKLAAQNAALAPPDAGSPLSSMTETLRRQILSQQQQHQQHHQQQAHHQQQPSHHQQQSPHAQSMNMYKSPAYLQRSEIEDQVSAAAAVAAAAAKHQQQQGERRGSENLPDLSALGLMGLPGLNVMPSRGSGGGSGGAAPNSAASYARELSRERERDRERERERELSRQYGSQSRGSSSGSGSAKSLTASQRPGAASPYSAAHYAKHQASAYNKRFLESLPAGIDLEAFANGLLQKSVNKSPRFEDFFPGPGQDMSELFANPDASAAAAAAAYAPPGAIRESPLMKIKLEQQHATELPHED
InterPro domains: - IPR009057: Homedomain-like superfamily (homologous_superfamily) [639-688]
- IPR000210: BTB/POZ domain (domain) [213-318]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [196-330]
- IPR051095: Drosophila Developmental Transcription Regulators (family) [170-984]
- IPR007889: DNA binding HTH domain, Psq-type (domain) [635-688]
Interaction partners: - TBP-associated factor 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0045927 (positive regulation of growth), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048609 (multicellular organismal reproductive process), GO:0040008 (regulation of growth), GO:0048639 (positive regulation of developmental growth), GO:0007276 (gamete generation), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0030707 (follicle cell of egg chamber development), GO:0007552 (metamorphosis), GO:0007281 (germ cell development), GO:0048729 (tissue morphogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0035107 (appendage morphogenesis), GO:0042335 (cuticle development), GO:0009880 (embryonic pattern specification), GO:0009891 (positive regulation of biosynthetic process), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0048634 (regulation of muscle organ development), GO:0048638 (regulation of developmental growth), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0007276 (gamete generation), GO:0048736 (appendage development), GO:0030707 (follicle cell of egg chamber development), GO:0042067 (establishment of ommatidial planar polarity), GO:0007281 (germ cell development), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0035282 (segmentation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0007423 (sensory organ development), GO:0048707 (instar larval or pupal morphogenesis), GO:0048477 (oogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0006325 (chromatin organization), GO:0048139 (female germ-line cyst encapsulation), GO:0002009 (morphogenesis of an epithelium), GO:0007350 (blastoderm segmentation), GO:0045229 (external encapsulating structure organization), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:0035150 (regulation of tube size), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048737 (imaginal disc-derived appendage development), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0048737 (imaginal disc-derived appendage development), GO:0008544 (epidermis development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0007423 (sensory organ development), GO:0048707 (instar larval or pupal morphogenesis), GO:0048569 (post-embryonic animal organ development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0051252 (regulation of RNA metabolic process), GO:0007444 (imaginal disc development), GO:0060429 (epithelium development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0001654 (eye development), GO:0007472 (wing disc morphogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0150063 (visual system development), GO:0035220 (wing disc development), GO:0040029 (epigenetic regulation of gene expression), GO:0008595 (anterior/posterior axis specification, embryo), GO:0035315 (hair cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0001738 (morphogenesis of a polarized epithelium), GO:0009913 (epidermal cell differentiation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0048749 (compound eye development), GO:0001745 (compound eye morphogenesis), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0005667 (transcription regulator complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0090575 (RNA polymerase II transcription regulator complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)