Protein: MAP kinase kinase skh1/pek1 (EC 2.7.12.2) (Q9Y884)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation.
Sequence: MSKKPVLNLDTSNGFSEEYISHPERNDNQGIVEITDLVFSSESKLTQRKESRDSKTFVPSFLEELDDDHLHELVTNGGILYMNSLGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQKQLLRELKINRSCTSPYIVKYYGACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRKIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSLAGTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPFPPEGSPPPMPIELLSYIINMPPPLLPQEPGIKWSKSFQHFLCVCLDKDKTRRPGPQKMLTHPWVKAFERIHVDMEEFLRQVWSD
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [77-348]
- IPR050915: MAP kinase kinase (family) [41-283]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [202-214]
- IPR017441: Protein kinase, ATP binding site (binding_site) [85-108]
- IPR000719: Protein kinase domain (domain) [79-343]
Interaction partners: - MAP kinase kinase kinase mkh1
- Mitogen-activated protein kinase spm1
- GTP-binding protein rho1
- Cell wall integrity and stress response component 1
- Protein kinase byr2
- Protein kinase byr1
- Mitogen-activated protein kinase sty1
- Mitogen-activated protein kinase spk1
- Stretch-activated cation channel yam8
- GTP-binding protein rho2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004712 (protein serine/threonine/tyrosine kinase activity), GO:0016301 (kinase activity), GO:0004708 (MAP kinase kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0019953 (sexual reproduction), GO:0050793 (regulation of developmental process), GO:0042221 (response to chemical), GO:2000241 (regulation of reproductive process), GO:0031139 (positive regulation of conjugation with cellular fusion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0031137 (regulation of conjugation with cellular fusion), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051726 (regulation of cell cycle), GO:0032005 (signal transduction involved in positive regulation of conjugation with cellular fusion), GO:0051445 (regulation of meiotic cell cycle), GO:0035556 (intracellular signal transduction), GO:0000747 (conjugation with cellular fusion), GO:0070887 (cellular response to chemical stimulus), GO:0043937 (regulation of sporulation), GO:0045595 (regulation of cell differentiation), GO:0010564 (regulation of cell cycle process), GO:0010033 (response to organic substance), GO:0019236 (response to pheromone), GO:0042173 (regulation of sporulation resulting in formation of a cellular spore), GO:0071310 (cellular response to organic substance), GO:0000749 (response to pheromone triggering conjugation with cellular fusion), GO:0060284 (regulation of cell development), GO:0000165 (MAPK cascade), GO:0034306 (regulation of sexual sporulation), GO:0000750 (pheromone-dependent signal transduction involved in conjugation with cellular fusion), GO:0043940 (regulation of sexual sporulation resulting in formation of a cellular spore), GO:0071444 (cellular response to pheromone)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)