Protein: Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like nucleoprotein (NP) (Core protein VII)] (P68951)
Organism: Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Function: Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Also plays a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
Subcellular location: [Histone-like nucleoprotein]: Virion {ECO:0000255|HAMAP-Rule:MF_04056}. Note=Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion. {ECO:0000255|HAMAP-Rule:MF_04056}.; SUBCELLULAR LOCATION: [Pre-histone-like nucleoprotein]: Host nucleus, host nucleolus {ECO:0000255|HAMAP-Rule:MF_04056}.
Sequence: MSILISPSNNTGWGLRFPSKMFGGAKKRSDQHPVRVRGHYRAPWGAHKRGRTGRTTVDDAIDAVVEEARNYTPTPPPVSTVDAAIQTVVRGARRYAKMKRRRRRVARRHRRRPGTAAQRAAAALLNRARRTGRRAAMRAARRLAAGIVTVPPRSRRRAAAAAAAAISAMTQGRRGNVYWVRDSVSGLRVPVRTRPPRN
InterPro domains: - IPR004912: Adenoviral core protein VII (family) [1-167]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0016032 (viral process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0019222 (regulation of metabolic process), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0009892 (negative regulation of metabolic process), GO:0051701 (biological process involved in interaction with host), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0039657 (suppression by virus of host gene expression), GO:0044003 (modulation by symbiont of host process), GO:0052026 (modulation by symbiont of host transcription), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0006338 (chromatin remodeling), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0051259 (protein complex oligomerization), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization), GO:0051260 (protein homooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0044094 (host cell nuclear part), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)