Protein: Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF) (P05113)
Organism: Homo sapiens (Human)
Function: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
Subcellular location: Secreted {ECO:0000269|PubMed:2653458}.
Sequence: MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
InterPro domains: - IPR000186: Interleukin-5 (family) [1-134]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [22-134]
Interaction partners: - Interleukin-5 receptor subunit alpha
- Interleukin-3
- Interleukin-2
- Interleukin-1 beta
- Cytokine receptor common subunit beta
- Interleukin-7
- Interleukin-9
- Granulocyte-macrophage colony-stimulating factor
- Interleukin-13
- Interleukin-4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032103 (positive regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0002694 (regulation of leukocyte activation), GO:1903706 (regulation of hemopoiesis), GO:0001817 (regulation of cytokine production), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:1903708 (positive regulation of hemopoiesis), GO:0031349 (positive regulation of defense response), GO:0051128 (regulation of cellular component organization), GO:0050865 (regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0050867 (positive regulation of cell activation), GO:0098542 (defense response to other organism), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0050776 (regulation of immune response), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0002274 (myeloid leukocyte activation), GO:0002699 (positive regulation of immune effector process), GO:0080090 (regulation of primary metabolic process), GO:0031347 (regulation of defense response), GO:0043254 (regulation of protein-containing complex assembly), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0022409 (positive regulation of cell-cell adhesion), GO:0051246 (regulation of protein metabolic process), GO:0022407 (regulation of cell-cell adhesion), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0070663 (regulation of leukocyte proliferation), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0010468 (regulation of gene expression), GO:0045637 (regulation of myeloid cell differentiation), GO:0045639 (positive regulation of myeloid cell differentiation), GO:0043412 (macromolecule modification), GO:0051251 (positive regulation of lymphocyte activation), GO:0050729 (positive regulation of inflammatory response), GO:0032740 (positive regulation of interleukin-17 production), GO:1902105 (regulation of leukocyte differentiation), GO:1902533 (positive regulation of intracellular signal transduction), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0070665 (positive regulation of leukocyte proliferation), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:0019221 (cytokine-mediated signaling pathway), GO:0043085 (positive regulation of catalytic activity), GO:0019221 (cytokine-mediated signaling pathway), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0051249 (regulation of lymphocyte activation), GO:0034097 (response to cytokine), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0045088 (regulation of innate immune response), GO:0032722 (positive regulation of chemokine production), GO:0071310 (cellular response to organic substance), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0097696 (receptor signaling pathway via STAT), GO:0010628 (positive regulation of gene expression), GO:0006796 (phosphate-containing compound metabolic process), GO:1904894 (positive regulation of receptor signaling pathway via STAT), GO:0036211 (protein modification process), GO:1902107 (positive regulation of leukocyte differentiation), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0002821 (positive regulation of adaptive immune response), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0002637 (regulation of immunoglobulin production), GO:0051338 (regulation of transferase activity), GO:0051253 (negative regulation of RNA metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0046427 (positive regulation of receptor signaling pathway via JAK-STAT), GO:0050670 (regulation of lymphocyte proliferation), GO:0045619 (regulation of lymphocyte differentiation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0045621 (positive regulation of lymphocyte differentiation), GO:0150077 (regulation of neuroinflammatory response), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0071345 (cellular response to cytokine stimulus), GO:0016310 (phosphorylation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0043549 (regulation of kinase activity), GO:0140888 (interferon-mediated signaling pathway), GO:0043410 (positive regulation of MAPK cascade), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0002573 (myeloid leukocyte differentiation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0050864 (regulation of B cell activation), GO:0050871 (positive regulation of B cell activation), GO:0031401 (positive regulation of protein modification process), GO:0043408 (regulation of MAPK cascade), GO:0050870 (positive regulation of T cell activation), GO:0051347 (positive regulation of transferase activity), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0031399 (regulation of protein modification process), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:0032816 (positive regulation of natural killer cell activation), GO:1901224 (positive regulation of NIK/NF-kappaB signaling), GO:0050829 (defense response to Gram-negative bacterium), GO:0032814 (regulation of natural killer cell activation), GO:0002706 (regulation of lymphocyte mediated immunity), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0046634 (regulation of alpha-beta T cell activation), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0002709 (regulation of T cell mediated immunity), GO:0042325 (regulation of phosphorylation), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0018108 (peptidyl-tyrosine phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0097028 (dendritic cell differentiation), GO:0042129 (regulation of T cell proliferation), GO:0042104 (positive regulation of activated T cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)