Protein: Structural maintenance of chromosomes protein 3 (B2FDA8)
Organism: Caenorhabditis elegans
Function: Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). Required for the localization of lab-1 to meiotic and mitotic chromosomes.
Subcellular location: Nucleus {ECO:0000269|PubMed:12827206, ECO:0000269|PubMed:21856158, ECO:0000269|PubMed:21957461}. Chromosome {ECO:0000269|PubMed:12827206}. Note=Has diffuse nuclear appearance at interphase during mitosis in somatic and germline tissues. {ECO:0000269|PubMed:12827206}.
Sequence: MKIKEVRITGFRSYKDNTNVSGFSPRSNVVVGRNGSGKSNFFHAIQFVLSDEYAHLKEEQRLGLLHESTGPKVAHARVEITFDNSEKRLMAFENSEVKIVRQVGKKKDQYYIDNKMVPRAEVVNLMESAGFSRSNPYYIVKQGKINELATSPDAYKLKLLREVAGTRVYDERKEESLKILKETKMKTEKIQGLLKYIDERLQTLENEKEDLKEYQKLDKTKRSVEYTMYDNTNKEAIKEKTKLDEQKVELNQKDNNVKSQLNDVIAEMAKLKTDKKKLESLGRGLREDKETLQAEETKMVEEKMTLKLEIDSLNEENTRERQGRQNAEHSLQGVGDEIFKNEEELDTIKPEYAKLLEEESRLKTDIRIDESRAKEILAKQGQRSQFSSVDDRDKFLRNEIRRISGLIADNKEREETIQKELADVEREDEKLNNEIQSISRTIDENRYEMDTFAAKSTSLKQEYDAAYVAQQTAAREEKAIRDKIGNTEQDISAANDQLRRIVARPVYNGITGVRKVIEEFKHDNRNGQHDDVINGYYGTVIELAEVPDMFRTAVEVIAQNRLFYHVVETDRIATKILRKFNEMQLPGEINFFPMNRVSAPRQRDLSNNSNARPMSDVIDYEVQYDKVFKSITANVIIVRTLDQAARDLRNEGFDVVSVDGDQMSKKGVMTGGFIDKKRSKLELHTQKDRFTKELAELQKSLAEAEKMVRERTQEAEKIRNRMQQHENQIGDFHRKHRELTEAKNAISQQFYMVTSTKEPKKDQLLGIKNHLRELLAQKENFEQEIGSNMSSQLTSDEEQTVKKLRKKVDEMTKQLATVSRRRMDLMHRKNAIENLLTKKLYKTKESLTARVDDISDNERRHKLENANAQLTSLLTRMESTRKQLATAISELQDYETKEKALQINIDNVLEQQRDLEKQQADFQLQYDKITAKEDEVKQKREDSLKKLILSRYSIKTRKNQFSYEISDSEEVGAKREPIEHRKLKISTFCLEYRAKLEKVHSNMRLLGALPTDTFSKWQNVKPRELEKKLLECVNELKKYENVNKKALDQYMTASSQKEELTKRMAEQKKSEDSIEELLKVLENRKYEAIDLTFKQVKKNFEQVFKQLVPHGRGKMQMRAREQRDDEEGINSVELYEGISVLVSFVSDDGDSETREMTQLSGGQKSLVALAIIFSIQKCDPAPFYLFDEIDAALDAQHRKSVADMIQSLSDQAQFVTTTFRPELLATAEKFYGVRFRNKVSHIDSVTREQAYDFVEDDTTHG
InterPro domains: - IPR036277: SMCs flexible hinge superfamily (homologous_superfamily) [483-694]
- IPR010935: SMCs flexible hinge (domain) [534-648]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-1255]
- IPR003395: RecF/RecN/SMC, N-terminal (domain) [3-1240]
- IPR041741: Structural maintenance of chromosomes 3, ABC domain, eukaryotic (domain) [3-151]
- IPR024704: Structural maintenance of chromosomes protein (family) [1-1253]
Interaction partners: - Sister chromatid cohesion protein 1
- Cohesin subunit scc-3
- Nipped-B-like protein scc-2
- Structural maintenance of chromosomes protein 1
- Cnd1 domain-containing protein
- Rad21_Rec8 domain-containing protein
- Wings apart-like protein homolog 1
- Maternal uncoordinated protein 2
- separase
- Separin homolog sep-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:2000243 (positive regulation of reproductive process), GO:0007275 (multicellular organism development), GO:2000241 (regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0051240 (positive regulation of multicellular organismal process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0007059 (chromosome segregation), GO:1903047 (mitotic cell cycle process), GO:0110037 (regulation of nematode male tail tip morphogenesis), GO:0110039 (positive regulation of nematode male tail tip morphogenesis), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0000278 (mitotic cell cycle), GO:0098813 (nuclear chromosome segregation), GO:0007076 (mitotic chromosome condensation), GO:0140014 (mitotic nuclear division), GO:0006325 (chromatin organization), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0010468 (regulation of gene expression), GO:0009792 (embryo development ending in birth or egg hatching), GO:0040029 (epigenetic regulation of gene expression), GO:0000819 (sister chromatid segregation), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0007549 (dosage compensation), GO:0030261 (chromosome condensation), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0044815 (DNA packaging complex), GO:0008278 (cohesin complex), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)