Protein: High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64) (P12314)
Organism: Homo sapiens (Human)
Function: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G.
Sequence: MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [20-282]
- IPR007110: Immunoglobulin-like domain (domain) [22-277]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [16-294]
- IPR013151: Immunoglobulin-like beta-sandwich domain (domain) [200-270]
- IPR003598: Immunoglobulin subtype 2 (domain) [34-267]
- IPR003599: Immunoglobulin domain subtype (domain) [28-281]
- IPR050488: Immunoglobulin Fc region receptor (family) [19-337]
Interaction partners: - Putative high affinity immunoglobulin gamma Fc receptor IB
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Insulin-like growth factor 1
- Tyrosine-protein kinase SYK
- High affinity immunoglobulin epsilon receptor subunit gamma
- Tyrosine-protein kinase HCK
- Transcription factor PU.1
- Insulin-like growth factor 2
- Tyrosine-protein kinase Lyn
- Low affinity immunoglobulin gamma Fc region receptor II-a
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048584 (positive regulation of response to stimulus), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0002253 (activation of immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0032101 (regulation of response to external stimulus), GO:0031349 (positive regulation of defense response), GO:0002218 (activation of innate immune response), GO:0031347 (regulation of defense response), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0045089 (positive regulation of innate immune response), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0002221 (pattern recognition receptor signaling pathway), GO:0002752 (cell surface pattern recognition receptor signaling pathway), GO:0140895 (cell surface toll-like receptor signaling pathway), GO:0034142 (toll-like receptor 4 signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005769 (early endosome), GO:0030135 (coated vesicle), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0030666 (endocytic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0045334 (clathrin-coated endocytic vesicle), GO:0030669 (clathrin-coated endocytic vesicle membrane), GO:0030665 (clathrin-coated vesicle membrane)