Protein: Chaperonin-containing T-complex member BBS12 (Bardet-Biedl syndrome 12 protein homolog) (Q5SUD9)
Organism: Mus musculus (Mouse)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
Subcellular location: Cell projection, cilium {ECO:0000250|UniProtKB:Q6ZW61}. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. {ECO:0000250|UniProtKB:Q6ZW61}.
Sequence: MEMACRVINRRRHVGLQQLLSFAQTGRSFLGPVKATKFITDAECHESVLISSTVRLLEGLDLTCAVGHLLNEAVQAQNNTYKIGTSTLLFLVGAWSRAVEDCLHLGIPTTVIVSVMSEGLNSCIEAVVSLQVPIHNVFDHMDNTSTVYKLETVNATLCPFLQDPSGSGLLQEKRDFKDATSPLLSTYSLSGRHAESPKFFKPQNNLETEKNTLQVLKNNLYTDSFCKKSALAHSRHFNRTDNSHWISRHDGFLEQLESTPKVLRCNDFGELAVGLSHGDHSSMALAKAAVRLQWQSLCLQQANWMAPFMFDISRLLTCCIPGLPETFSRVGLGYVTFVTMSSITLIKELQDQPFRVILIEGDLTESYRHLGFNKSVNIKTKLDSGELSEDSAEELWTNHVLQVLIQFNVTLILVQGSVSEHLTEKCMHSKRLVIGAVNGSVLQAFAEATRAVPVAYVTQVNEDCVGSGVSVTFWMSPHDINRSNRIAILLTAEGINLITAVLTSPASAQMETKEDRFWSCVYRLYHALKEEKVFLGGGAVEFLCLSHLQILAEQSLNRGNHACLGWLPDSSSWMASSLSVYRPTVLKSLAGGWHEFLSAIMCNTATHPSAVEARTFIQQHVQNAIDSGSPSSYILSEYSKLSSGVFHSGISDNLELVPRVYDTVTPKIEAWRRALDVVLLVLQTDSEIITGLVHTEMNSQELDGVLFL
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [495-530]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [333-494]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [376-554]
- IPR042984: Chaperonin-containing T-complex member BBS12 (family) [149-696]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [12-689]
Interaction partners: - BBSome complex assembly protein BBS10
- BBSome complex member BBS7
- Protein PTHB1
- BBSome complex member BBS2
- BBSome complex member BBS4
- BBSome complex member BBS1
- BBSome complex member BBS5
- Tetratricopeptide repeat protein 8
- Leucine zipper transcription factor-like protein 1
- Molecular chaperone MKKS
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0071840 (cellular component organization or biogenesis), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0045596 (negative regulation of cell differentiation), GO:0045598 (regulation of fat cell differentiation), GO:0043933 (protein-containing complex organization), GO:0045599 (negative regulation of fat cell differentiation), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051131 (chaperone-mediated protein complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0030141 (secretory granule), GO:0043227 (membrane-bounded organelle), GO:0001669 (acrosomal vesicle), GO:0031982 (vesicle), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)