Protein: Myelin and lymphocyte protein (T-lymphocyte maturation-associated protein) (VIP17 proteolipid) (Q28296)
Organism: Canis lupus familiaris (Dog) (Canis familiaris)
Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MAPAAASGGSSLPSGFSVFTTFPDLLFIFEFIFGGLVWILIASSLVPIPLVQGWVMFVSVFCFMATTALLVLYIIGAHGGENSWVTLDAAYHCIAALFYLSASVLEALATIGMQEGYTYKQYHENISAVVFSYVATLLYVVHAVFSLIRWKSS
InterPro domains: - IPR013295: Myelin and lymphocyte (MAL) protein (family) [32-139]
- IPR008253: Marvel domain (domain) [18-151]
- IPR050578: MARVEL domain-containing and chemokine-like factor proteins (family) [13-152]
Interaction partners: - Myelin associated oligodendrocyte basic protein.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0005253 (monoatomic anion channel activity), GO:0005254 (chloride channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0007272 (ensheathment of neurons), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0008366 (axon ensheathment), GO:0051668 (localization within membrane), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0007417 (central nervous system development), GO:0008104 (protein localization), GO:0007399 (nervous system development), GO:0042552 (myelination), GO:0061024 (membrane organization), GO:0045176 (apical protein localization), GO:0031579 (membrane raft organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)