Protein: Ferrichrome outer membrane transporter/phage receptor (P06971)
Organism: Escherichia coli (strain K12)
Function: Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane. In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1. The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system
Subcellular location: Cell outer membrane; Multi-pass membrane protein
Sequence: MARSKTAQPKHSLRKIAVVVATAVSGMSVYAQAAVEPKEDTITVTAAPAPQESAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNPVNTDFDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVATATFRF
InterPro domains: - IPR010105: TonB-dependent siderophore receptor (family) [78-747]
- IPR010917: TonB-dependent receptor, conserved site (conserved_site) [730-747]
- IPR037066: TonB-dependent receptor, plug domain superfamily (homologous_superfamily) [54-193]
- IPR000531: TonB-dependent receptor-like, beta-barrel (domain) [254-716]
- IPR010916: TonB box, conserved site (conserved_site) [1-47]
- IPR012910: TonB-dependent receptor, plug domain (domain) [76-180]
- IPR039426: TonB-dependent receptor-like (family) [33-747]
- IPR036942: TonB-dependent receptor-like, beta-barrel domain superfamily (homologous_superfamily) [194-747]
Interaction partners: - Protein TonB
- Biopolymer transport protein ExbD
- Biopolymer transport protein ExbB
- Iron(3+)-hydroxamate import ATP-binding protein FhuC
- Iron(3+)-hydroxamate-binding protein FhuD
- Iron(3+)-hydroxamate import system permease protein FhuB
- Ferric siderophore reductase
- Ferric enterobactin-binding periplasmic protein FepB
- Maltoporin
- Outer membrane protein A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0015643 (toxic substance binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0019904 (protein domain specific binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0031323 (regulation of cellular metabolic process), GO:0098771 (inorganic ion homeostasis), GO:0023019 (signal transduction involved in regulation of gene expression), GO:0080090 (regulation of primary metabolic process), GO:0098657 (import into cell), GO:0055080 (monoatomic cation homeostasis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0033212 (iron import into cell), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0010468 (regulation of gene expression), GO:0055072 (iron ion homeostasis), GO:0006812 (monoatomic cation transport), GO:2001141 (regulation of RNA biosynthetic process), GO:0033214 (siderophore-dependent iron import into cell), GO:0006355 (regulation of DNA-templated transcription), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport), GO:1901678 (iron coordination entity transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0009279 (cell outer membrane), GO:0019867 (outer membrane), GO:0030313 (cell envelope)