Protein: Importin subunit alpha-8 (Karyopherin subunit alpha-7) (A9QM74)
Organism: Homo sapiens (Human)
Function: Functions in nuclear protein import.
Subcellular location: Nucleus {ECO:0000269|PubMed:20701745, ECO:0000269|PubMed:36647821}.
Sequence: MPTLDAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGEEEDESQTLLSQVIDQDYEFIDYECLAKK
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [10-491]
- IPR032413: Atypical Arm repeat (repeat) [448-495]
- IPR002652: Importin-alpha, importin-beta-binding domain (domain) [1-92]
- IPR024931: Importin subunit alpha (family) [2-514]
- IPR011989: Armadillo-like helical (homologous_superfamily) [58-486]
- IPR000225: Armadillo (repeat) [102-439]
- IPR036975: Importin-alpha, importin-beta-binding domain superfamily (homologous_superfamily) [9-51]
Interaction partners: - Importin subunit beta-1
- Interleukin-1 family member 10
- Butyrophilin subfamily 3 member A1
- GTP-binding nuclear protein Ran
- Mucin-3A
- Exportin-2
- Forkhead box protein P1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0043933 (protein-containing complex organization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0022607 (cellular component assembly), GO:0006606 (protein import into nucleus), GO:0065003 (protein-containing complex assembly), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0006607 (NLS-bearing protein import into nucleus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0043233 (organelle lumen), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)