Protein: Beta-glucosidase 42 (AtBGLU42) (EC 3.2.1.21) (Q9FIW4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Glucosidase that hydrolyzes scopolin and various beta-glucosides, cellooligosaccharides (mainly cellotriose) and laminarioligosaccharides. Can use p-nitrophenyl-beta-glucosides (pNP beta-Glc) and p-nitrophenyl-beta-D-fucosides (pNP beta-D-Fuc) as substrates, and, to a lower extent, beta-galactosides, beta-mannosides and beta-xylosides. Involved in the secretion of root-derived phenolics upon iron ions (Fe) depletion. Promotes disease resistance toward B.cinerea, H.arabidopsidis and P.syringae pv. tomato DC3000. Required during rhizobacteria-mediated (e.g. P.fluorescens WCS417r) broad-spectrum induced systemic resistance (ISR) against several pathogens.
Sequence: MAQKLNLLNLAVPPVTHRSNFPSTFTFGVATSAYQIEGGWNEGKKGPSIWDKFTHIEGKILDGSNGDVAVDHYHRYKEDVDLIGQLGFGAYRFSISWSRIFPDGLGTEVNEEGIAFYNDLINTLLEKGIQPYVTLYHWDLPSHLQEAIGGWTNRKIVDYFGLYADACFANFGDRVKHWITLNEPLQTSVNGHCIGIFAPGRNEKPLIEPYLVSHHQVLAHATAVSIYRSKYKESQGGQIGLSVDCEWAEPNSEKPEDKVAADRRIDFQLGWFLDPLFFGDYPASMRQKLGDNLPRFTPEEKEFMLQNSWDFLGLNHYTSRLISHVSNKEAESNFYQAQELERIVELENGDLIGERAASDWLYAVPWGIRKTLNYMSKKYNHPPIFITENGMDDEDDGSASIHDMLDDKRRVDYFKSYLANVSQAIEDGVDIKGYFAWSLLDNFEWAQGYTKRFGLVYVDYKNGLTRHPKSSAYWFMKFLKGDEENKGKKE
InterPro domains: - IPR001360: Glycoside hydrolase family 1 (family) [18-486]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [15-480]
- IPR033132: Glycosyl hydrolases family 1, N-terminal conserved site (conserved_site) [25-39]
- IPR017736: Glycoside hydrolase, family 1, beta-glucosidase (family) [21-475]
Interaction partners: - Transcription factor MYB72
- Feruloyl CoA ortho-hydroxylase 1
- ABC transporter G family member 37
- Ferric reduction oxidase 2
- Fe
- Scopoletin 8-hydroxylase
- Transcription factor MYB10
- Xanthotoxin 5-hydroxylase CYP82C4
- Transcription factor ORG3
- Oligopeptide transporter 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009698 (phenylpropanoid metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009808 (lignin metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0009699 (phenylpropanoid biosynthetic process), GO:0009809 (lignin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)