Protein: Inositol hexakisphosphate kinase 2 (Q80V72)
Organism: Mus musculus (Mouse)
Function: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity). May play a role in the regulation of Na(+)-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity)
Subcellular location: Nucleus
Sequence: MSPAFRTMDVEPRTKGILLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRRFTPQYKAVLIFVRCADEFGASGNIETKEQGVVSVRFEEDEDRNLCLIAYPLKGDHGTVDIVDNSDCEPKSKLLRWTNKKHHALETEKNPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYSVEKKGNVSSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGTGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKEWPEVTLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDSVVHEGQDAGYIFGLQSLIDIVTEISEESGE
InterPro domains: - IPR038286: Inositol polyphosphate kinase superfamily (homologous_superfamily) [169-447]
- IPR005522: Inositol polyphosphate kinase (family) [17-446]
Interaction partners: - Inositol-pentakisphosphate 2-kinase
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
- Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
- Inositol hexakisphosphate kinase 1
- Inositol hexakisphosphate kinase 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0045926 (negative regulation of growth), GO:0071704 (organic substance metabolic process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:1901615 (organic hydroxy compound metabolic process), GO:0010942 (positive regulation of cell death), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0010941 (regulation of cell death), GO:0070887 (cellular response to chemical stimulus), GO:0019637 (organophosphate metabolic process), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0044255 (cellular lipid metabolic process), GO:0006066 (alcohol metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0051128 (regulation of cellular component organization), GO:0010033 (response to organic substance), GO:0006793 (phosphorus metabolic process), GO:0043647 (inositol phosphate metabolic process), GO:0046486 (glycerolipid metabolic process), GO:1905395 (response to flavonoid), GO:0043067 (regulation of programmed cell death), GO:0006644 (phospholipid metabolic process), GO:0043068 (positive regulation of programmed cell death), GO:0019751 (polyol metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0008654 (phospholipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0046488 (phosphatidylinositol metabolic process), GO:0046854 (phosphatidylinositol phosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)