Protein: Cell wall acid trehalase ATC1 (Q5AAU5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Cell wall acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Plays a role in dimorphic conversion and virulence
Subcellular location: Secreted, cell wall
Sequence: MAANSSFFLADNCAPHNQSFIQFCIHAASKKKGRIALMCLANLFLLFSFHLLYARFCSGFPYVVPSTARSTNQIFHTNLEQLVNSPENKQIFSQLKFSDQAFYDPHDNVVGTTEFPVFNQYQRQPYVANGYIGSRIPNLGQGFTYDQLTNSSTANDDDLLNGWPLFNKRYSGAFVAGFYDLQKNTTGTNFAELLENGYESVIAAVPQWTALSLSVEILGKKYTLDPSLEHEAIGDITNYVQNMSLSDGIVTTQFTWLNTFDVKYEILAHRENINLGLVNMQVYNPGNESVQVIVSDVLDFNSSQRCQLNQISHDKNGIYVTFHPQGLSYIDGAIYSTLSANGQITREQTNETVFQNVELTIEPHSCVQVAKYVGIATTDLDPDSFKTADDVLKFARKVSQNKKHGDATQLVNSHRSAWSKIIQDAPLVTFPSDSLLNLGARASIFHLLANTRPNAEGVTGALGVSGLSSDSYGGMVFWDTDLWMLNGILPFAPDHIKSFINYRVHLHQQAIDNVPRGYQGAVYPWTSGRFGNCTGTGPCLDYEYHINMAVAMASWQLYISGAADDTFLESVAYPIINDAASFLAEYVVHYNDTLGKYTTKNLTDPDEFANHVDNGAYTNTGIVLVMRWAQIAGSILGKQVPKIYHDIETAMFLPTAENTQNITLEYSGMNSSVGIKQADVIMMTYPLENELIDQDQAYINMEFYSMKQVGYGPAMTFPIFSIVASNLAFTGCASQSYLHKAIQPFLRGPFAQFAEQNNDDYLTNGGTHPAFPFLTAHGGFLQAILQGLTGMRFDYTFENNKLQRLLKLDPIALPCLGEGVRFDSIKYDNHTLSMAINETHFTIKNKGKTTPNARNYVTILLAERNAMHGKYTINDEDEQSFPLFETSESFPDSISECNKAGFFNITEGAYGDVSISINDGDNTTSWQAKYNDTTGKVLVDLKSFRNISSGTFIWGDKPPKRVKVSKYSGSSFTAVTDFFAQVDFGNELFNEYKYANPEGKLHNQSDVFEEVYSGDVKISAPFDPEEYFQVWVPTRHNITEVAVNLQTRFLLIEVDEIHNTEAIDGDYGGAKLAEVVFY
InterPro domains: - IPR037018: Glycoside hydrolase family 65, N-terminal domain (homologous_superfamily) [109-379]
- IPR005196: Glycoside hydrolase, family 65, N-terminal (domain) [119-379]
- IPR012341: Six-hairpin glycosidase-like superfamily (homologous_superfamily) [437-771]
- IPR008928: Six-hairpin glycosidase superfamily (homologous_superfamily) [388-844]
- IPR005195: Glycoside hydrolase, family 65, central catalytic (domain) [442-633]
- IPR011013: Galactose mutarotase-like domain superfamily (homologous_superfamily) [166-378]
Interaction partners: - Trehalase
- Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015927 (trehalase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0005984 (disaccharide metabolic process), GO:0005991 (trehalose metabolic process), GO:0046352 (disaccharide catabolic process), GO:0009313 (oligosaccharide catabolic process), GO:0005993 (trehalose catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)