Protein: Cytoplasmic dynein 2 heavy chain 1 (Q9JJ79)
Organism: Rattus norvegicus (Rat)
Function: May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme. Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Localizes to the apical cytoplasm. May localize to Golgi apparatus, cytoplasmic vesicle and endoplasmic reticulum (By similarity)
Sequence: MAGSLSDVRKLFLFTTTQNYFGLRPELWDQTPLSNCPEVNNFLDDGNQMLLRVQRSDAGLAFSNTIDFDDTKDKVLVFFKLRPEVITDGNLHTNILVSSMLESPINSLYQAVRQVFAPMLLKDQEWSRNFDPKLQNLLSELEAGLGVVLRKSDTNLPKLKLKEDDTRGILTPSDEFQFWIEQAHRGSKQISKERASYFKELFETIAREFYNLDSLSLLEVVDLVETTRDVVDDVWRQAEHDHYPESRMLHLLDVIGGSFGRFVQKKLGSLKLWEDPYYLVKENLKAGISICEQWVIVCSHLTGQVWQRYVPHPWKSEKYFPETLDRLGKRLEEVLAIRTIHEKLLYFLPASEERIVCLSRVFEPFTGVNPVQYNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKELMLERETLLARLGDSAKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNNIVWVRQLELKVDDTIKIAEALLSDLSGFRSFHRSAEDLLDQFKLYEQEQFDDWSREVQSGLSDSRSGLCIEANSRIMELDPNDGALKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANVAQKFCKQAIILKQVAHFYNSIDQQMIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENRRLRKWHITFCEKVVILMNIDLLRQQQRWKDGLQELRTGLASVAAQGFQPSDMRAWRQHWNHQLYKALEHQYQMGLEALNENLPEINVDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFKGVGGAGDESIFSVMIDRNASGFLTIYSKAEDLFRRLSAVLHQHKEWVVIGQVDMEALVEKNLSTVHDWEKNFKALKIKGKEVERLPSAVKVDCLNINCSPVKTVIDDLIQKLFDLLVLSLKKSIQTHIHEIDTFVTEAMKVLTVIPQSVEEIGDTNLQYSNLQDRRPEILPLFQEAEDKNRLLRTVAGGGVETVSNLRAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELDKFKARWDQLKPGDDIIETGQQNTMDQSAKSIKEKKIEFDDLEVIRKKLVDDCHHFGLEESNFSLAYSISKDIESCAQIWALYEEFQQGLQEMAKEDWITYRTKIYIFEEFLINWHERLRKVEEHSVMTVKLQSEVDRYKIIIPILKYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVEKASDLKDLNSRAQGEVTIREALRELDLWGVGAVFSLIDYEDSQNRTIKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWERKLAQLDEYLQNLNHIQRKWVYLEPIFGRGALPKEQTRFNKVDEDFRSIMMDIRKDSRVTTLTTHAGIRNTLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQSTNPSVIQSHLKKLFAGINSVCFDEESKHITAMRSLEGEVVPFKSKVLLSNNVEAWLNDLALEMKQTLKQLLKECVTAGRSSQGAIDPSLFPSQILCLAEQIKFTEDVEDAIRDHSLHQIEAQLAAKLERYTSVDTSSEDPGNSESGILELKLKTLILDIIHNIDIVKQLNQAQVHTTDDWAWKKQVRFYMKSDHTCYVQMVDSELQYTYEYQGNAPKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEEAVLSAVSMQIQTIQDALKNHRSVCELLGKEVEVNANSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSRPDNDLIAEVILYSEGFKDAKELGRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLRQLKKSGTKQDVNENHIVVQALRLNTMSKFTFADCTRFDALIKDVFPGIDFKEVEYNELSSALKQVFEEANYEVIPNQMKKALELYEQLRQRTGVVIVGPSGAGKSTLWRMLRAALCKIGKVVKQYTMNPKAMPRHQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNRLLTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQPVEYRSNLENWIGDYFSKALQWVLKQNDYVVETSLVGTVMNGLSHLHGCKYHDQFIINLIRGLGGNLNMKSRLEFTKEVFNWARETPPDSHRPMDTYFDCDRGQLASYVLKKPESLTADDFSSGHSLPVIQTPDMQRGLDYFKPWLSSETKQPFILVGPEGCGKGMLLRYAFSQLRSTEIATIHCSAQTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQGFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCAVDYPEREQLQTIYGAYLEAVLHKNLKNHSIWGSSSKIYLLAGSMVQVYEQVRAKFTVDDYSHYFFTPCILTQWVLGLFRYDLEGGSSNHPLDYVLEVVAYEARRLFRDKIVGVKELHLFDNILTSVLQGDWGSDILDNMADSFYVTWGAQHISGAKIAPGQPLPPHGKPLGKLSSADLKDVIKKGLIHYGRDNQNLDILLFQEVLEYMSRIDRVLSFPGGSLLLAGRSGVGRRTVTSLVSHMHGAVLFSPKISRGYEPKQFRTDLKHVLHLAGIEAQQVVLLLEDYQFVHPTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFGPVFNYFTYRIQQNLHIVLIMDSANLNFIINCESNPALHKKCRVLWMEGWSDSSMKKIPEMLFSEADIEEKYEKKRKDEKKKSSVDPDFIKSFLLIHESCKAYGATPSRYMTFLRVYSAISSSKRKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSILLRIKQDEADSALQEITVSMQDASEQKTELERLKHRIAEEVVKIEERKSKIDDELKEVQPLVNEAKLAVGNIRPESLSEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNIPKEIRESVEELLFKNKASFDPKNAKRASTAAAPLAAWVKANVQYSHVLERIQPLETEQSGLELNLKKTEDRKRKLEDLLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLISQLDREHRRWNAQVAEIAEELATLPKRAQLAAAFITYLSAAPEGLRKNCLEEWTKAAGLEKFDLRRFLCTESEQLIWKSEGLPSDDLSIENALVILQSRVCPFLIDPSSQATEWLKTHLKDSHLEVINQQDSNFITALELAVRFGKTLIIQEMDGVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEDFRLFLSTRNPNPFIPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLARLEESLLETLATSQGNILENKDLIESLNQTKASSALIQDSLKESYKLQISLDRERDAYLPLAESASKMYFIISDLSKINNMYRFSLASFLRLFQRALQNKQDSESTEQRIQCLVNSLKHMVYEYICRCLFKADQLMFALHFVRGMHPEFFQENEWDTFTGVVVGDMLRKADSQQRIRDQLPSWIDQERSWAVATLKISLPGLYQTLCFEDGTLWRTYYHHSMCEQEFPSILAKKVSLFQQVLVVQALRPDRLQSAMALFACKALGLKELSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSSERYHQVAMGQGQADLAIQMLKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPKESFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNLMRTYESWTPEQISKKDNIHRAHALFSLAWFHAACQERRNFIPQGWTKFYEFSLSDLRAGYHVIDRLFDGSKDVQWEFVHGLLENSIYGGRIDNYFDLRVLQSYLKQFFNSSIIDVLNQRNKKSIFPYSISLPDSCSILDYRAVIEKLPEDDKPSFFGLPANIARSSQRMTSSQVISQLRILGRSVTAGCKFDREIWSNELSPVLNLWKKLNQNSNLIHQKVSPPNDRQGSPILSFIILEQFNAIRLVQSVHQSLAALSKVIRGTTLLSSEVQKLASALLNQKCPLTWQSKWEGPEDPLQYLRGLVARTLAIQNWVEKAEKQALLADTLDLSELFHPDTFLNALRQETARATGCSVDSLKFVASWKGRLQEAKLQIKISGLLLEGCSFDGSRLSENQHDSPSVSSVLPCYMGWTPQGSYGPYSPDECISLPVYTSAERDCVVTNIDVPCGGNQDQWIQCGAALFLKNQ
InterPro domains: - IPR043157: Dynein heavy chain, AAA1 domain, small subdomain (homologous_superfamily) [1819-1935]
- IPR042219: Dynein heavy chain AAA lid domain superfamily (homologous_superfamily) [3831-3998]
- IPR041658: Dynein heavy chain AAA lid domain (domain) [3861-4000]
- IPR042228: Dynein heavy chain, linker, subdomain 3 (homologous_superfamily) [1425-1521]
- IPR043160: Dynein heavy chain, C-terminal domain, barrel region (homologous_superfamily) [4175-4306]
- IPR024743: Dynein heavy chain, coiled coil stalk (domain) [2896-3226]
- IPR035699: Dynein heavy chain, hydrolytic ATP-binding dynein motor region (domain) [1651-1986]
- IPR013602: Dynein heavy chain, linker (domain) [1120-1518]
- IPR042222: Dynein heavy chain, domain 2, N-terminal (homologous_superfamily) [1259-1424]
- IPR049400: Cytoplasmic dynein 2 heavy chain 1, AAA+ ATPase domain (domain) [2121-2216]
- IPR054354: Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain (domain) [2445-2544]
- IPR013594: Dynein heavy chain, tail (domain) [200-652]
- IPR041228: Dynein heavy chain, C-terminal domain (domain) [4009-4303]
- IPR004273: Dynein heavy chain region D6 P-loop domain (domain) [3720-3828]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1666-3830]
- IPR024317: Dynein heavy chain, AAA module D4 (domain) [2625-2880]
- IPR026983: Dynein heavy chain (family) [192-4305]
- IPR003593: AAA+ ATPase domain (domain) [1684-2431]
- IPR035706: Dynein heavy chain, ATP-binding dynein motor region (domain) [3252-3469]
Interaction partners: - Cytoplasmic dynein 2 light intermediate chain 1
- Cytoplasmic dynein 2 intermediate chain 1
- Cytoplasmic dynein 2 intermediate chain 2
- Cytoplasmic dynein 1 light intermediate chain 1
- Dynein light chain 1, cytoplasmic
- Dynein light chain 1, cytoplasmic
- Dynein light chain 1, cytoplasmic
- Dynein light chain 1, cytoplasmic
- Cytoplasmic dynein 1 intermediate chain 2
- Dynein light chain 2, cytoplasmic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0097305 (response to alcohol), GO:0045471 (response to ethanol)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0098794 (postsynapse), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0099572 (postsynaptic specialization), GO:0043228 (non-membrane-bounded organelle), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0099091 (postsynaptic specialization, intracellular component), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0098978 (glutamatergic synapse), GO:0030425 (dendrite), GO:0032279 (asymmetric synapse), GO:0099092 (postsynaptic density, intracellular component)