Protein: Inactive caspase-12 (CASP-12) (Q6UXS9)
Organism: Homo sapiens (Human)
Function: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Sequence: MADEKPSNGVLVHMVKLLIKTFLDGIFDDLMENNVLNTDEIHLIGKCLKFVVSNAENLVDDITETAQIAGKIFREHLWNSKKQLSSDISSDGEREANMPGLNIRNKEFNYLHNRNGSELDLLGMRDLLENLGYSVVIKENLTAQEMETALRQFAAHPEHQSSDSTFLVFMSHSILNGICGTKHWDQEPDVLHDDTIFEIFNNRNCQSLKDKPKVIIMQACRGNGAGIVWFTTDSGKASADTHGRLLQGNICNDAVTKAHVEKDFIAFKSSTPHNVSWRHETNGSVFISQIIYYFREYSWSHHLEEIFQKVQHSFETPNILTQLPTIERLSMTRYFYLFPGN
InterPro domains: - IPR011600: Peptidase C14, caspase domain (domain) [103-336]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [8-87]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [93-339]
- IPR001315: CARD domain (domain) [11-92]
- IPR002398: Peptidase C14 family (family) [103-341]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [254-339]
- IPR033139: Peptidase family C14A, cysteine active site (active_site) [211-222]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [101-340]
- IPR001309: Peptidase C14, p20 domain (domain) [101-224]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0002682 (regulation of immune system process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048522 (positive regulation of cellular process), GO:0009607 (response to biotic stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0048609 (multicellular organismal reproductive process), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0060759 (regulation of response to cytokine stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:1901564 (organonitrogen compound metabolic process), GO:0035234 (ectopic germ cell programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0080134 (regulation of response to stress), GO:0019538 (protein metabolic process), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060760 (positive regulation of response to cytokine stimulus), GO:0001817 (regulation of cytokine production), GO:0043170 (macromolecule metabolic process), GO:0098542 (defense response to other organism), GO:0010646 (regulation of cell communication), GO:0002702 (positive regulation of production of molecular mediator of immune response), GO:0002697 (regulation of immune effector process), GO:0009617 (response to bacterium), GO:0010623 (programmed cell death involved in cell development), GO:0010647 (positive regulation of cell communication), GO:0016043 (cellular component organization), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0031347 (regulation of defense response), GO:0001961 (positive regulation of cytokine-mediated signaling pathway), GO:0006508 (proteolysis), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0070269 (pyroptosis), GO:0002718 (regulation of cytokine production involved in immune response), GO:0051604 (protein maturation), GO:0010628 (positive regulation of gene expression), GO:0032652 (regulation of interleukin-1 production), GO:0010468 (regulation of gene expression), GO:0050727 (regulation of inflammatory response), GO:0050729 (positive regulation of inflammatory response), GO:0042742 (defense response to bacterium), GO:0006915 (apoptotic process), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0010467 (gene expression), GO:0097435 (supramolecular fiber organization), GO:0002720 (positive regulation of cytokine production involved in immune response), GO:0010935 (regulation of macrophage cytokine production), GO:0061081 (positive regulation of myeloid leukocyte cytokine production involved in immune response), GO:0016485 (protein processing), GO:0032651 (regulation of interleukin-1 beta production), GO:0050830 (defense response to Gram-positive bacterium), GO:0032731 (positive regulation of interleukin-1 beta production), GO:0060907 (positive regulation of macrophage cytokine production), GO:0016540 (protein autoprocessing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0061702 (inflammasome complex), GO:0005737 (cytoplasm)