Protein: COP9 signalosome complex subunit 5 (Q59PG6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes
Subcellular location: Cytoplasm. Nucleus
Sequence: MTCLDELAHSLESKSDTTNFKTRNSKIKTIDLYQQNELSGKHPQDQDKFYRLPAIDPIARDKKPWKEDINYFNKCYISSLALMKMCTHAQTGGSIEIMGMLVGKISGHSIIVMDTYRLPVEGTETRVNAQNEAYTYMVEYLTERQQLSNGKNEENIVGWYHSHPGYGCWLSGIDVSTQSLNQGFQDPYLAIVVDPVKTLKQGKVEIGAFRTYPEGSQQQPSMTNKTRKDQNKPHNSGANANRKILPKSKQKDFGSHADKYYSLDIEIFTSSWDDKVIEMLKDEDSLTWMKNLLVDSNNNDKILGIRKDEIRSIELIKNYELISQGNHNADEGETIFDLIEQLKIQANTPKFMLDKLTTMKFDSTFESVLYKRLLKKTQKSTTTKKNRKDLSTDIDDETMLDESDLEKNVGTGGIETSISSDDDDEEEEGEGEGNSSSRRDNNNNEVEEGPTDEVDSEYANEELLEEVGALENYNFNDLLENKSANKFLRSEQKIKHKNRPIHQRMDNSSMISEWNRLGHQQQHMPADYPYQWSSNVANLVKTSKTNRRRERLHRLQGASIDNKKQFELGLHGSPESKAKSANLVKLAKSIGLNEVFDLITLDAQQKLFG
InterPro domains: - IPR037518: MPN domain (domain) [75-215]
- IPR000555: JAB1/MPN/MOV34 metalloenzyme domain (domain) [72-214]
- IPR050242: JAMM/MPN+ metalloenzymes, peptidase M67A (family) [62-345]
Interaction partners: - JAB1/MPN/MOV34 metalloenzyme domain-containing protein
- F-box protein COS111
- PCI domain-containing protein
- PCI domain-containing protein
- Cullin
- NEDD8 family protein
- E3 ubiquitin ligase complex SCF subunit
- Defective in cullin neddylation protein 1
- Cullin
- SCF ubiquitin ligase complex subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0000003 (reproduction), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0048856 (anatomical structure development), GO:0019954 (asexual reproduction), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0043170 (macromolecule metabolic process), GO:0033554 (cellular response to stress), GO:0036211 (protein modification process), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0043412 (macromolecule modification), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels), GO:0070646 (protein modification by small protein removal), GO:0070647 (protein modification by small protein conjugation or removal), GO:0016570 (histone modification), GO:0016579 (protein deubiquitination), GO:0016578 (histone deubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0008180 (COP9 signalosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)