Protein: Transcriptional regulatory protein UME6 (Q59MD2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promotes filamentous biofilms and is required for adherence to surfaces such as plastic. Plays an important role in virulence
Subcellular location: Nucleus
Sequence: MITHMVTPDSTSSAPNSPYGEDTIKLNSSVISSSSPVRSTSYLQNLQLQQQFSQLQFLQLQQQQQQQDQQLALQQQQQQQQSQSQQAQPYANPYFQTPIDQLFQFDNNPNSSFNPTRPPNIHTNQPYVSPYLHSAPLTNHSDLQPQPPPASLSDSELGLGLVKQQQDSLPPQQQAQSQPTPLLNQQHPFYNEYINDMPSTQHPYLIFNNTNAAHSTTSLPNLDAANPSSILPQSALNQSEYYKVTNGSMSNDPQPSTFLYNLHNHSADLVMNNDLEFSNASFDSIGGVSVSAAATGAGAGAGDYSHTNITSNFAQTNLHSSSQQSGVLPPPPSLPPPPTSLPSQQSQNQYLDVVPPQQLTNNALKTEANSPLITDSANFTTSQPQFENTILEQSPIFSNNTILSGIDEPSKEKSPNMLNSTLPLSKSTPHHIYQPSSSSSSHVRHNKITKKSSLSRLNTSSKKNLRANLVHSLSTPTELDDANNNNNDIVTPPKTLSPLLRKKTSFINVKKENDIDDSHDINCKNFSIDIDDMDDEDVLSDFSQPPPPIGGVSNDTMRSLAPVGGVGLGSSGNITGYRSLSNASSTSSHGSHHGLPVMNIFRHNPDSTKPSTPSPILSTASSSSTLSNKKVVKKLRGRKSKTKMNKSSIKTEQVVNEEPQVKNYKDDNDNDNDNGHGHDHDDENGGVSSDVGTGSNSTPSTTTKGKKMKLNVDLNNGGGSGTGSGSCSDENTSGNGTNTNTDSTSTSNPMVKKKHTRRRLLPRSKKGCWICRIKHLKCDEVTPICGGCAKFGLQCDYSSEKPAYVTDKILRQKKLTEVSLIRKRNQAKTKISRKKSSNDITND
InterPro domains: - IPR001138: Zn(2)Cys(6) fungal-type DNA-binding domain (domain) [762-806]
- IPR036864: Zn(2)-C6 fungal-type DNA-binding domain superfamily (homologous_superfamily) [759-800]
- IPR051700: STE20 Ser/Thr Protein Kinase (family) [49-755]
Interaction partners: - Serine/threonine-protein kinase TOR
- Hypha-specific G1 cyclin-related protein 1
- Hyphal wall protein 1
- DNA-binding transcriptional regulator
- non-specific serine/threonine protein kinase
- Transcriptional regulator
- Agglutinin-like protein 3
- Transcriptional regulator NRG1
- Extent of cell elongation protein 1
- Biofilm regulator 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001217 (DNA-binding transcription repressor activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001227 (DNA-binding transcription repressor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:0007584 (response to nutrient), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0080090 (regulation of primary metabolic process), GO:0071496 (cellular response to external stimulus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0031670 (cellular response to nutrient), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0045990 (carbon catabolite regulation of transcription), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071396 (cellular response to lipid), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0000429 (carbon catabolite regulation of transcription from RNA polymerase II promoter), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045991 (carbon catabolite activation of transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0000436 (carbon catabolite activation of transcription from RNA polymerase II promoter)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)