Protein: E3 ubiquitin-protein ligase Topors (A0A8M1P6B6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MASPQIKERPSGVVLNTISKGASPESKCPICLDHFKNISYLDVCLHKFCFCCIHEWSKNKAECPLCKQPFNSFYHTIKSEDDYKRFDLRPTENGSFGNMAGQRFRYRTTLTGDRRPVQRRTSPPPDHGIIFEGLRGSLPQRHNRDLHSMIRRLTVRQRRESEGRSLRSLQDQEVVKFRRALYRRGVQVQSVQDGGRTRETSAEFFKRNPACLHRLVPWLRRELTVLYGAHGSLVNIVQHIIMTLITRHNLDDQAVQHELRPFLLSHTEHFLHEFLSFARSPFNMEAYDQRAVYDLPRPSGESSSSENSVIAISEDESESLVSGAQDFATPRVTSSQTAWDDETPGPSYSSERSQVLPVHVRDSDSDSSVGEAVMPIAAVRHQDHPANPSTIQPEEDHSSSNDEDCVIIGYVKPVAERTPELVQLSSDSENSETEQNASPRNSQAPQHIRFISDSDASPTASQRPLRGPASSSRSFEDTSIQLRKNSKYDNTFSGSREGSSQSKRIHSSSHRKKQPLCKESKNKQRGEKETSRHSSSYWHSYSYYSHDNSRKAYTETSSSYTSYYRSVNDQFGSRSHGKRRCRDLLDRSRSRSNSRISQSNRRNRSRSRSNSRISRSNQRNRSHSRSNSGKSQSNRRNRSCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNQRNRRHSRSNSRISQSSRQNRSLSRSNSRKGYSNRRNRNHSRSSSRVSQSSQRNRSHSRSNFRIKSSSYKSQDEKYQRSLSRSLYSNNDVRSRSRSSSRINTSSRQDRRRSRSSSRMNSSSSRQTSCHDKYGKKRMYKTKHHEKPSRQSSSKSVGDSDEVGGKKKKKKHTKRRKTRSPSIDDRSEGHSQRHHKRKKKHKKKSKRHNSKERTRKLSPVLITITTDSDGESADPSEPSTSSVCAIRSTVLIANMATEAFLDNEHQSTAGTENSSVGDAGNYP
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [27-67]
- IPR058746: Topors, zinc finger, RING-type (domain) [25-70]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [44-53]
- IPR058745: Topors, PWI-like domain (domain) [206-280]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [22-87]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:2000241 (regulation of reproductive process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0042127 (regulation of cell population proliferation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0008284 (positive regulation of cell population proliferation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)