Protein: Pro-FMRFamide-related neuropeptide FF (FMRFamide-related peptides) [Cleaved into: Neuropeptide SF (NPSF); Neuropeptide FF (NPFF); Neuropeptide AF (NPAF)] (O15130)
Organism: Homo sapiens (Human)
Function: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels.
Subcellular location: Secreted.
Sequence: MDSRQAAALLVLLLLIDGGCAEGPGGQQEDQLSAEEDSEPLPPQDAQTSGSLLHYLLQAMERPGRSQAFLFQPQRFGRNTQGSWRNEWLSPRAGEGLNSQFWSLAAPQRFGKK
InterPro domains: - IPR008065: Pro-FMRFamide-related neuropeptide FF (family) [1-113]
Interaction partners: - Neuropeptide FF receptor 1
- Neuropeptide FF receptor 2
- Proto-oncogene Mas
- Prolactin-releasing peptide
- Prolactin-releasing peptide receptor
- Orexigenic neuropeptide QRFP
- Mas-related G-protein coupled receptor member D
- Metastasis-suppressor KiSS-1
- Mas-related G-protein coupled receptor member X2
- Mas-related G-protein coupled receptor member X3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0001664 (G protein-coupled receptor binding), GO:0005179 (hormone activity), GO:0005184 (neuropeptide hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0051049 (regulation of transport), GO:0035556 (intracellular signal transduction), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0006810 (transport), GO:0043271 (negative regulation of monoatomic ion transport), GO:0034762 (regulation of transmembrane transport), GO:0008217 (regulation of blood pressure), GO:0003013 (circulatory system process), GO:0034763 (negative regulation of transmembrane transport), GO:0003012 (muscle system process), GO:0032413 (negative regulation of ion transmembrane transporter activity), GO:0034766 (negative regulation of monoatomic ion transmembrane transport), GO:0008015 (blood circulation), GO:0003073 (regulation of systemic arterial blood pressure), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0006936 (muscle contraction), GO:0003015 (heart process), GO:0051926 (negative regulation of calcium ion transport), GO:0016192 (vesicle-mediated transport), GO:0043269 (regulation of monoatomic ion transport), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0032780 (negative regulation of ATP-dependent activity), GO:1903522 (regulation of blood circulation), GO:0019932 (second-messenger-mediated signaling), GO:0006941 (striated muscle contraction), GO:0006937 (regulation of muscle contraction), GO:0008016 (regulation of heart contraction), GO:0006812 (monoatomic cation transport), GO:0060047 (heart contraction), GO:1903170 (negative regulation of calcium ion transmembrane transport), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0046474 (glycerophospholipid biosynthetic process), GO:1904063 (negative regulation of cation transmembrane transport), GO:0010959 (regulation of metal ion transport), GO:0019722 (calcium-mediated signaling), GO:0051924 (regulation of calcium ion transport), GO:0010882 (regulation of cardiac muscle contraction by calcium ion signaling), GO:1903169 (regulation of calcium ion transmembrane transport), GO:0099080 (supramolecular complex)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)