Protein: mitogen-activated protein kinase (B6K747)
Organism: Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast)
Sequence: MDRRHRVYRVFHQEMFVEPNFKVVKELGQGAYGIVCAAKNMASKEQEGVAIKKITNIFSKPILTKRALREIKLLIHLRNHRNMEADLNAIIKSGQPLTDAHFQSFIYQILCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLARGFSDNPDENAGFMTEYVATRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGRPFFKGKDYVHQLNLILHYLGTPDEETLSRISSERAYNYIRSFPPKKPIPFETIFPYANPLALDLLSRMLTFDPAKRISVTEALEHPYLAVWHDPADEPECPIPFDFSFEAINDMNELRDLIQREVLAFRRNVRRSPNPSLPHLHPIQINSQLSSRASAMHSQHSGHVSNHLRSSMPTSNTQNESNDLSPRPHSPRLDANDLEAELSKY
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [121-133]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [15-298]
- IPR017441: Protein kinase, ATP binding site (binding_site) [27-53]
- IPR000719: Protein kinase domain (domain) [21-290]
- IPR050117: Mitogen-activated protein (MAP) kinase (family) [24-350]
Interaction partners: - G2/mitotic-specific cyclin cig1
- Transcription factor
- protein-tyrosine-phosphatase
- Transcription factor prr1
- protein-tyrosine-phosphatase
- STE/STE7 protein kinase Pek1
- cAMP-dependent protein kinase
- MBF transcription factor complex subunit Cdc10
- non-specific serine/threonine protein kinase
- Tyrosine phosphatase Pyp1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016740 (transferase activity), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0004707 (MAP kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0035556 (intracellular signal transduction), GO:0006979 (response to oxidative stress), GO:0009314 (response to radiation), GO:0019538 (protein metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010948 (negative regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0009408 (response to heat), GO:0051726 (regulation of cell cycle), GO:0010035 (response to inorganic substance), GO:0104004 (cellular response to environmental stimulus), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0045786 (negative regulation of cell cycle), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0071478 (cellular response to radiation), GO:0034599 (cellular response to oxidative stress), GO:0009416 (response to light stimulus), GO:0000075 (cell cycle checkpoint signaling), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:0000165 (MAPK cascade), GO:0006796 (phosphate-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0031098 (stress-activated protein kinase signaling cascade), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0071241 (cellular response to inorganic substance), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0042542 (response to hydrogen peroxide), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:1901988 (negative regulation of cell cycle phase transition), GO:0051403 (stress-activated MAPK cascade), GO:2001141 (regulation of RNA biosynthetic process), GO:0006468 (protein phosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0071482 (cellular response to light stimulus), GO:0016310 (phosphorylation), GO:0071248 (cellular response to metal ion), GO:0009411 (response to UV), GO:0034614 (cellular response to reactive oxygen species), GO:0070301 (cellular response to hydrogen peroxide), GO:0000077 (DNA damage checkpoint signaling), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071276 (cellular response to cadmium ion), GO:2000142 (regulation of DNA-templated transcription initiation), GO:0010224 (response to UV-B), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0034644 (cellular response to UV), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)