Protein: Patched domain-containing protein 3 (RND-type protein RNDEu-3) (Q0EEE2)
Organism: Mus musculus (Mouse)
Function: May play a role in sperm development or sperm function. However, does not appear to have an essential role in spermatogenesis or male fertility.
Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:17904097}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3KNS1}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the midpiece of the sperm tail. {ECO:0000269|PubMed:17904097}.
Sequence: MISSKVAPGEEEQGESPSKVELGEAEEQREAPLEGQLEAVPLDEAGPSWTTGPPLERLPPLGQEAPPPRRCHTNCLEAPLSRGFQRFGATVGANPWLFLLGPALLTASLGTGLIFLPKEKENLEEQYTPIGSPAKAERRFVQGHFSTNDTYRFSASRTSSETNFASILVVSLANSLLEPEIFKEVSKLDQAVQALKVVQENGTQILYQEVCAKYKTLCVPPNPLLFSWQHNSSLNLSDLTFPIHNTPTQLIYLAGFFGGNVLGQMTGKSQRLVESRAMRLLYYLKTEDPEDSERSQAWLTHFLDHFNDMKSSLTLEEIEVVYFSSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLDCIRNKMCVAVFGVFSVAMSVVSGFGLMLHLGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLSESIRERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAVMALDGKREVAWSRWLEKPDQKYSSLKKSCCVPFGSLIDKHGEDNHPMNLFFRDYFGPFLTTSKAKFIVVLLYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTESVNYWDNDVRQKLDKCMTQFEENEYVDKNLTEFWLEAYMQYMNSSGNNPNDKNTFMNNIAGFLQFFPIFTYDINISSSNEITSSRGFIQIVDVSSSSNKKRMLLKLRSIAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSTEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLSAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF
InterPro domains: - IPR051697: Patched domain-containing protein (family) [75-906]
- IPR003392: Patched domain-containing protein, SSD domain (domain) [349-496]
- IPR000731: Sterol-sensing domain (domain) [339-496]
Interaction partners: - Protein dispatched homolog 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0001503 (ossification), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0033036 (macromolecule localization), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0009887 (animal organ morphogenesis), GO:0010646 (regulation of cell communication), GO:0060042 (retina morphogenesis in camera-type eye), GO:0001649 (osteoblast differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0070727 (cellular macromolecule localization), GO:0060041 (retina development in camera-type eye), GO:0072001 (renal system development), GO:0060348 (bone development), GO:0001501 (skeletal system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0008104 (protein localization), GO:0001822 (kidney development), GO:0008589 (regulation of smoothened signaling pathway), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0097225 (sperm midpiece), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium), GO:0036126 (sperm flagellum)