Protein: Phosphatase and actin regulator 1 (Q2M3X8)
Organism: Mus musculus (Mouse)
Function: Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization.
Subcellular location: Cytoplasm. Synapse {ECO:0000250}. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import. {ECO:0000250}.
Sequence: MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELTLASYAAQKSSQQAVAQHHHTVLPSQMQHQLQYGSHGQHLPSSTGTLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEPDYEDSPCLYGREEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
InterPro domains: - IPR004018: RPEL repeat (repeat) [138-523]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0019902 (phosphatase binding), GO:0003779 (actin binding), GO:0019903 (protein phosphatase binding), GO:0008157 (protein phosphatase 1 binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050790 (regulation of catalytic activity), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0044093 (positive regulation of molecular function), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0035556 (intracellular signal transduction), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0030036 (actin cytoskeleton organization), GO:0035295 (tube development), GO:0051726 (regulation of cell cycle), GO:0060900 (embryonic camera-type eye formation), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0048864 (stem cell development), GO:0060562 (epithelial tube morphogenesis), GO:0021915 (neural tube development), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0002072 (optic cup morphogenesis involved in camera-type eye development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0002009 (morphogenesis of an epithelium), GO:0060485 (mesenchyme development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0001667 (ameboidal-type cell migration), GO:0072175 (epithelial tube formation), GO:0048863 (stem cell differentiation), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0048484 (enteric nervous system development), GO:0060606 (tube closure), GO:0007264 (small GTPase mediated signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:2001044 (regulation of integrin-mediated signaling pathway), GO:0048483 (autonomic nervous system development), GO:0014033 (neural crest cell differentiation), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0002011 (morphogenesis of an epithelial sheet), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0048048 (embryonic eye morphogenesis), GO:0031076 (embryonic camera-type eye development), GO:0090497 (mesenchymal cell migration), GO:0061386 (closure of optic fissure), GO:0001843 (neural tube closure), GO:0150063 (visual system development), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0001841 (neural tube formation), GO:0014032 (neural crest cell development), GO:0007266 (Rho protein signal transduction), GO:0043010 (camera-type eye development), GO:0014020 (primary neural tube formation), GO:0048593 (camera-type eye morphogenesis), GO:0048596 (embryonic camera-type eye morphogenesis), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)