Protein: Neutrophil defensin 3 (Defensin, alpha 3) (HNP-3) (HP-3) (HP3) [Cleaved into: HP 3-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)] (P59666)
Organism: Homo sapiens (Human)
Function: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses. Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus. Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment.
Subcellular location: Secreted {ECO:0000269|PubMed:29282039}.
Sequence: MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC
InterPro domains: - IPR002366: Alpha-defensin, N-terminal (domain) [1-52]
- IPR006081: Alpha-defensin, C-terminal (domain) [66-94]
- IPR016327: Alpha-defensin (family) [1-94]
- IPR006080: Beta/alpha-defensin, C-terminal (domain) [66-94]
Interaction partners: - Neutrophil defensin 1
- Defensin alpha 4
- Beta-defensin 1
- Defensin beta 4A
- Beta-defensin 103
- T-cell surface glycoprotein CD4
- Beta-defensin 104
- Beta-defensin 107
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0043207 (response to external biotic stimulus), GO:0009755 (hormone-mediated signaling pathway), GO:0070887 (cellular response to chemical stimulus), GO:0030595 (leukocyte chemotaxis), GO:0006959 (humoral immune response), GO:0071674 (mononuclear cell migration), GO:0006952 (defense response), GO:0071495 (cellular response to endogenous stimulus), GO:0030522 (intracellular receptor signaling pathway), GO:0006935 (chemotaxis), GO:0002251 (organ or tissue specific immune response), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0016477 (cell migration), GO:0060326 (cell chemotaxis), GO:0019730 (antimicrobial humoral response), GO:0030518 (intracellular steroid hormone receptor signaling pathway), GO:0032870 (cellular response to hormone stimulus), GO:0071310 (cellular response to organic substance), GO:0033993 (response to lipid), GO:0048545 (response to steroid hormone), GO:0072676 (lymphocyte migration), GO:0014070 (response to organic cyclic compound), GO:0002385 (mucosal immune response), GO:0043401 (steroid hormone mediated signaling pathway), GO:0048247 (lymphocyte chemotaxis), GO:0030520 (intracellular estrogen receptor signaling pathway), GO:0071383 (cellular response to steroid hormone stimulus), GO:0071396 (cellular response to lipid), GO:0072678 (T cell migration), GO:0061844 (antimicrobial humoral immune response mediated by antimicrobial peptide), GO:0071407 (cellular response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0005615 (extracellular space), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0034774 (secretory granule lumen), GO:0005796 (Golgi lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:0005766 (primary lysosome)