Protein: Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) (Q96C24)
Organism: Homo sapiens (Human)
Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
Subcellular location: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). {ECO:0000250}.
Sequence: MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL
InterPro domains: - IPR035892: C2 domain superfamily (homologous_superfamily) [348-647]
- IPR041282: FYVE-type zinc finger (domain) [9-122]
- IPR037303: Synaptotagmin-like protein 4/5, C2A domain (domain) [357-481]
- IPR000008: C2 domain (domain) [356-633]
- IPR044134: Synaptotagmin-like protein 4 , FYVE-related domain (domain) [58-107]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [8-129]
- IPR043567: Synaptotagmin-like 1-5, C2B domain (domain) [496-661]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1-144]
- IPR001565: Synaptotagmin (domain) [360-463]
- IPR010911: Rab-binding domain (domain) [4-122]
Interaction partners: - Ras-related protein Rab-27A
- Syntaxin-binding protein 1
- Ras-related protein Rab-3A
- Ras-related protein Rab-8A
- Ras-related protein Rab-27B
- One cut domain family member 2
- Syntaxin-1A
- Syntaxin-3
- Insulin
- Unconventional myosin-Va
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0140352 (export from cell), GO:0051234 (establishment of localization), GO:0032940 (secretion by cell), GO:0006810 (transport), GO:0046903 (secretion), GO:0016192 (vesicle-mediated transport), GO:0006887 (exocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0098590 (plasma membrane region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0030667 (secretory granule membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle)