Protein: Trehalose import ATP-binding protein SugC (P9WQI3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular trehalose released from trehalose-containing molecules synthesized by M.tuberculosis. Trehalose uptake is essential for virulence. Responsible for energy coupling to the transport system
Subcellular location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side
Sequence: MAEIVLDHVNKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKTTTLNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLAKMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQTEAMTLGDRVVVMYGGIAQQIGTPEELYERPANLFVAGFIGSPAMNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQDAALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAEVEGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHRA
InterPro domains: - IPR015855: ABC transporter, maltose/maltodextrin import, MalK-like (domain) [4-217]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [4-243]
- IPR003593: AAA+ ATPase domain (domain) [29-220]
- IPR008995: Molybdate/tungstate binding, C-terminal (homologous_superfamily) [237-388]
- IPR047641: ABC transporter, ATP-binding protein MalK/UgpC-like (family) [1-387]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [345-372]
- IPR040582: MalK-like, OB fold domain (domain) [236-287]
- IPR017871: ABC transporter-like, conserved site (conserved_site) [135-149]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [4-235]
Interaction partners: - Trehalose-binding lipoprotein LpqY
- Trehalose-binding lipoprotein LpqY
- Trehalose transport system permease protein SugB
- Trehalose transport system permease protein SugB
- Trehalose transport system permease protein SugA
- Trehalose transport system permease protein SugA
- Probable sugar-transport integral membrane protein ABC transporter UspA
- Probable sugar-transport integral membrane protein ABC transporter
- Probable sugar-transport integral membrane protein ABC transporter UspB
- Probable sugar-transport integral membrane protein ABC transporter
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0140657 (ATP-dependent activity), GO:0042626 (ATPase-coupled transmembrane transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0140359 (ABC-type transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0008643 (carbohydrate transport), GO:0015772 (oligosaccharide transport), GO:0015766 (disaccharide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005886 (plasma membrane)