Protein: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7 (A0A2R8PVI8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm. Golgi apparatus. Membrane
Sequence: MMRSSSSRLSFSSKEPIWNRMPDQISVSEFLSETTEDYNSPTTSSFTTRLQSCRNTVSVLEEALDQDRTSLQKVKKSVKAIYNSGQDHIQNEETYSQALDKFGSNFISRDNPDLGTAFVKFSTLTKELSALLKNLLQNLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQVDQKEDSQSKQGGYSMHQLQGNKEFGCEKKGYLLKKSDGLRKVWQRRKCSVKGGILTISHATSNRQPVKLNLLTCQVKPSAEDRKCFDLISHNRTYHFQAEDEQEFIIWISVLTNSKEEALNMAFRGEQGGGDDGLEDLTKAIIDDVLRMPGNEWCCDCGAPDPKWLSTNLGILTCIECSGIHREMGVHISRIQSMELDKLGTSELLLAKNVGNSSFNDIMEGGLSCPSSKPTPSSDMTVRKEFINAKYVDHKFARKTCSSAEDKRSDLFKAVGSHDLLALIQVYAEGVELLEPLHEGGQEGGETALHYAVRTADQTSLHLVDFLVQNSGNLDKQTERGNTALHYCCLYEKHECLKLLLRGKPATDITNQNGDTALDVARRMKLFQCEEALVQAAAGKFNTKVHVEYEWNLRLEELDESDDDLDYKPSPIKKDRSPRPQSFCHSSSLSPHDKLSLPAFIGQRDKQRLSYSAFTNQMYSVSTDCPSSPVSDAPPLPPRNAGKGSDSTPPPVNKMSPVTNRFEGIPQQQSPNTTKPTLGPRVLPKLPQKVALRKIDTIHHPSVDKTNQPSEAVLFQKVLQSSDTSQKVPIADRPQPGDVAPQRPQPSELPPKPGELPPKPQLSELPPKPQLGDLPPKPQLKDLPPKPQLADISPAKPITIEVPPKPSPGEVAPKPQPPDTPTIIQQGELSPQPVIQSSEDTNGSPTSAQDTPVPLPRKINPIKSKMRRVKTIYDCQADNDDELTFAEGEVIVVTGEEDQEWWIGHIEGQPERKGVFPMSFVHILSD
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [992-1081]
- IPR038016: ASAP1, SH3 domain (domain) [1024-1080]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [319-433]
- IPR037928: ASAP1, BAR domain (domain) [54-268]
- IPR037278: ARFGAP/RecO-like zinc finger (homologous_superfamily) [438-555]
- IPR038508: ArfGAP domain superfamily (homologous_superfamily) [434-560]
- IPR001849: Pleckstrin homology domain (domain) [324-418]
- IPR001452: SH3 domain (domain) [1020-1082]
- IPR002110: Ankyrin repeat (repeat) [600-699]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [560-709]
- IPR043593: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein (family) [21-1082]
- IPR037844: ASAP, PH domain (domain) [316-422]
- IPR001164: Arf GTPase activating protein (domain) [439-562]
- IPR027267: AH/BAR domain superfamily (homologous_superfamily) [39-347]
- IPR004148: BAR domain (domain) [54-286]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0003824 (catalytic activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0005096 (GTPase activator activity), GO:0030695 (GTPase regulator activity), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0009790 (embryo development), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0016477 (cell migration), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0001667 (ameboidal-type cell migration), GO:0060026 (convergent extension), GO:0042074 (cell migration involved in gastrulation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)