Protein: Cell adhesion molecule DSCAM (Down syndrome cell adhesion molecule homolog) (Q9ERC8)
Organism: Mus musculus (Mouse)
Function: Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC. In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:19196994}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:19196994, ECO:0000269|PubMed:22685302}. Synapse {ECO:0000250|UniProtKB:F1NY98}. Cell projection, dendrite {ECO:0000269|PubMed:22685302}. Cell projection, growth cone {ECO:0000269|PubMed:22685302}. Note=Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons. {ECO:0000269|PubMed:19196994}.
Sequence: MWILALSLFQSFANVFSEEPHSSLYFVNASLQEVVFASTSGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYVTVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENSRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGNEDQELSWYRNGEILNPGKNVRITGLNHANLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLVCNVKGTPLPTVTWTLDDDPILKGSGHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNANLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPASLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEITITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCVANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQSEEGLTTNEGLKILVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRATGSVDKESDSYSVSPSQDTDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTSSTPSESGICRFTASPPKPQDGGRVVNMAVPKAHRPGDLIHLPPYLRMDFLLNRGAPGTSRDLSLGQACLEPQKSRTLKRPTVLEPTPMEASSSTSSTREGQQSWQQGAVATLPQREGAELGQAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [885-1558]
- IPR013106: Immunoglobulin V-set domain (domain) [241-1361]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [32-1384]
- IPR003961: Fibronectin type III (domain) [885-1575]
- IPR013098: Immunoglobulin I-set (domain) [232-882]
- IPR007110: Immunoglobulin-like domain (domain) [20-1377]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [21-1565]
- IPR056754: DSCAM/DSCAML, C-terminal domain (domain) [1487-1575]
- IPR003598: Immunoglobulin subtype 2 (domain) [37-1366]
- IPR003599: Immunoglobulin domain subtype (domain) [130-1377]
Interaction partners: - Netrin-1
- Netrin receptor DCC
- Cell adhesion molecule DSCAML1
- Draxin
- Netrin receptor UNC5A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0048639 (positive regulation of developmental growth), GO:0045597 (positive regulation of cell differentiation), GO:0032103 (positive regulation of response to external stimulus), GO:2000026 (regulation of multicellular organismal development), GO:0050920 (regulation of chemotaxis), GO:0001558 (regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0032101 (regulation of response to external stimulus), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0030307 (positive regulation of cell growth), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0050921 (positive regulation of chemotaxis), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0061387 (regulation of extent of cell growth), GO:0032535 (regulation of cellular component size), GO:0050770 (regulation of axonogenesis), GO:0045773 (positive regulation of axon extension), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0030516 (regulation of axon extension), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050767 (regulation of neurogenesis), GO:0050772 (positive regulation of axonogenesis), GO:0008361 (regulation of cell size), GO:0048841 (regulation of axon extension involved in axon guidance), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030054 (cell junction), GO:0045202 (synapse)