Protein: Sialate:O-sulfotransferase 1 (Q80XH4)
Organism: Mus musculus (Mouse)
Function: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycolipids such as GM1 gangliosides
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence: MAKPFFRLQKFLRRTQFLLLFLTAAYLMTGSLLLLQRARVALPQALRAPGSLQALPVATVALGVGLLDGRSLRDPHSSPDLLLDVDTLRSPLARLPPGIRWPRRNRSSLRRRWLHHLTSDPQGPPTLSPEASGPANHNRGNYLGCFSEEGQERTLKGAVFYDLRKMTVSHCQDACAERSYVYAGLEAGAECYCGNRLPATRVSLKECNQECKGEKGSMCGAVRRLSVYSVGLQQPGSKKRRTATYRGCFPLPENVTHTFSSSMTQANMTVETCSGFCSQKEFPLAILRGWDCYCAYPTPQFSLRDAVDGALCSQAPETQGLPGYCEVYQTPVQDTRCTDRKFLPDKSKVFVALSSFPGAGNTWARHLIEHATGFYTGSYYFDGTLYNKGFKGEKDHWRSRRTICVKTHESGRREIEMFDSAILLIRNPYRSLVAEFNRKCAGHLGYAPDRNWKSKEWPEFVNSYASWWSSHVLDWLKYGKRLLVVHYEELRHSLVPTLREMVAFLNVSVSEERLLCVENNKEGSFRRRGRRPHDQEPFTPEMKDLINGYIRTVDQALRDHNWAGLPREYVPR
InterPro domains: - IPR051589: Sialate:O-sulfotransferase (family) [10-570]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [324-559]
- IPR000863: Sulfotransferase domain (domain) [422-515]
- IPR002889: Carbohydrate-binding WSC (domain) [139-337]
Interaction partners: - Fanconi anemia group M protein homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0008146 (sulfotransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0002252 (immune effector process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0007610 (behavior), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0044249 (cellular biosynthetic process), GO:0030534 (adult behavior), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006790 (sulfur compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0007626 (locomotory behavior), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0042060 (wound healing), GO:0006518 (peptide metabolic process), GO:0030204 (chondroitin sulfate metabolic process), GO:0009100 (glycoprotein metabolic process), GO:0044272 (sulfur compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0006022 (aminoglycan metabolic process), GO:0006029 (proteoglycan metabolic process), GO:0030203 (glycosaminoglycan metabolic process), GO:0009101 (glycoprotein biosynthetic process), GO:0030206 (chondroitin sulfate biosynthetic process), GO:0006023 (aminoglycan biosynthetic process), GO:0050654 (chondroitin sulfate proteoglycan metabolic process), GO:0006024 (glycosaminoglycan biosynthetic process), GO:1903510 (mucopolysaccharide metabolic process), GO:0030166 (proteoglycan biosynthetic process), GO:0050650 (chondroitin sulfate proteoglycan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)