Protein: Forkhead box protein D3-A (FoxD3-A) (FoxD3a) (Fork head domain-related protein 6) (FKH-6) (Forkhead protein 6) (xFD-6) (xFKH6) (Q9DEN4)
Organism: Xenopus laevis (African clawed frog)
Function: Transcriptional repressor that is an essential upstream regulator of neural crest determination and mesoderm induction. Functions by recruiting the transcriptional corepressor tle4. Also acts in a negative auto-regulator loop by inhibiting the transcription of its own gene.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:17138566}.
Sequence: MTLSGSGSASDMSGQTVLSADDADIDVVGEGDEALDKDSECESTAGHTDEVGELGGKEIPRSPSGSGTEAEGKGESQQQQQEGIQNKPKNSLVKPPYSYIALITMSILQSPQKKLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPQSEDMFDNGSFLRRRKRFKRQQQDSLREQTALMMQSFGAYSLASPYGRHYGLHPAAYTHPAALQYPYIPPVGHMLPPAVPLLPSSELTRKAFSSQLSPSLQLQLSSLSSTAASIIKSEPSSRPSFSIENIIGVSAASSAAPHTFLRPPVTVQSALMSHQPLALSRSTAAIGPILSVPTNLISGQFLPTAAAAVAKWPAQ
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [93-188]
- IPR050211: Forkhead box domain-containing protein (family) [42-322]
- IPR030456: Fork head domain conserved site 2 (conserved_site) [138-144]
- IPR047392: Forkhead box protein D3, forkhead domain (domain) [93-189]
- IPR001766: Fork head domain (domain) [92-188]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [81-189]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0051961 (negative regulation of nervous system development), GO:0045596 (negative regulation of cell differentiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0050768 (negative regulation of neurogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0060284 (regulation of cell development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051960 (regulation of nervous system development), GO:0010721 (negative regulation of cell development), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0050767 (regulation of neurogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)