Protein: T-cell surface glycoprotein YE1/48 (Lymphocyte antigen 49a) (Ly-49a) (T lymphocyte antigen A1) (P20937)
Organism: Mus musculus (Mouse)
Function: Receptor on natural killer (NK) cells for H-2d alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location: Membrane; Single-pass type II membrane protein.
Sequence: MSEQEVTYSMVRFHKSAGLQKQVRPEETKGPREAGYRRCSFHWKFIVIALGIFCFLLLVAVSVLAIKIFQYDQQKNCEEFLNHHNNCSNMQSDINLKDEMLKNKSIECDLLESLNRDQNRLYNKTKTVLDSLQHTGRGDKVYWFCYGMKCYYFVMDRKTWSGCKQACQSSSLSLLKIDDEDELKFLQLVVPSDSCWVGLSYDNKKKDWAWIDNRPSKLALNTGKYNIRDGGCMLLSKTRLDNGNCDQVFICICGKRLDKFPH
InterPro domains: - IPR013600: Ly49-like, N-terminal (domain) [40-153]
- IPR016186: C-type lectin-like/link domain superfamily (homologous_superfamily) [126-262]
- IPR052013: Mouse Killer cell lectin-like receptors (family) [1-262]
- IPR016187: C-type lectin fold (homologous_superfamily) [120-258]
- IPR001304: C-type lectin-like (domain) [139-254]
- IPR033992: Natural killer cell receptor-like, C-type lectin-like domain (domain) [142-255]
Interaction partners: - H-2 class I histocompatibility antigen, D-B alpha chain
- Beta-2-microglobulin
- H-2 class I histocompatibility antigen, K-B alpha chain
- TYRO protein tyrosine kinase-binding protein
- Histocompatibility 2, M region locus 3
- Natural killer cells antigen CD94
- Partner of Y14 and mago
- Killer cell lectin-like receptor subfamily B member 1C
- Natural cytotoxicity triggering receptor 1
- GTP-binding protein GEM
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0042287 (MHC protein binding), GO:0042288 (MHC class I protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0008283 (cell population proliferation), GO:0002683 (negative regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002682 (regulation of immune system process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0031341 (regulation of cell killing), GO:0050777 (negative regulation of immune response), GO:0009968 (negative regulation of signal transduction), GO:0002831 (regulation of response to biotic stimulus), GO:0010648 (negative regulation of cell communication), GO:0050776 (regulation of immune response), GO:0032102 (negative regulation of response to external stimulus), GO:0010469 (regulation of signaling receptor activity), GO:0010646 (regulation of cell communication), GO:0002697 (regulation of immune effector process), GO:0044092 (negative regulation of molecular function), GO:0080134 (regulation of response to stress), GO:0050673 (epithelial cell proliferation), GO:0009966 (regulation of signal transduction), GO:0032101 (regulation of response to external stimulus), GO:0002698 (negative regulation of immune effector process), GO:0007166 (cell surface receptor signaling pathway), GO:0002832 (negative regulation of response to biotic stimulus), GO:0031348 (negative regulation of defense response), GO:0031342 (negative regulation of cell killing), GO:2000272 (negative regulation of signaling receptor activity), GO:0031347 (regulation of defense response), GO:1904893 (negative regulation of receptor signaling pathway via STAT), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0001911 (negative regulation of leukocyte mediated cytotoxicity), GO:0002704 (negative regulation of leukocyte mediated immunity), GO:0045824 (negative regulation of innate immune response), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0002716 (negative regulation of natural killer cell mediated immunity), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0045953 (negative regulation of natural killer cell mediated cytotoxicity), GO:0002715 (regulation of natural killer cell mediated immunity), GO:0002707 (negative regulation of lymphocyte mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)