Protein: MAGUK p55 subfamily member 3 (Q13368)
Organism: Homo sapiens (Human)
Function: Participates in cell spreading through the phosphoinositide- 3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K). Stabilizes HTR2C at the plasma membrane and prevents its desensitization. May participates in the maintenance of adherens junctions (By similarity)
Subcellular location: Cell membrane. Apical cell membrane. Cell junction, adherens junction. Note=Localized in apical villi of Mueller glia cells (By similarity). Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (By similarity). Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina
Sequence: MPVLSEDSGLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAVALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVSWVR
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [181-312]
- IPR035604: MPP3, SH3 domain (domain) [230-291]
- IPR001478: PDZ domain (domain) [137-218]
- IPR001452: SH3 domain (domain) [226-296]
- IPR014775: L27 domain, C-terminal (domain) [12-120]
- IPR050716: Membrane-associated guanylate kinase (family) [7-584]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [372-585]
- IPR004172: L27 domain (domain) [6-121]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [384-573]
- IPR020590: Guanylate kinase, conserved site (conserved_site) [420-437]
- IPR008144: Guanylate kinase-like domain (domain) [385-570]
- IPR036034: PDZ superfamily (homologous_superfamily) [131-218]
- IPR036892: L27 domain superfamily (homologous_superfamily) [67-118]
Interaction partners: - Protein lin-7 homolog C
- Cell adhesion molecule 1
- Protein lin-7 homolog A
- Cell adhesion molecule 3
- Glutamate receptor ionotropic, NMDA 2A
- Protein lin-7 homolog B
- Glutamate receptor ionotropic, NMDA 2B
- F-box/SPRY domain-containing protein 1
- Tyrosine-protein kinase Lck
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0009888 (tissue development), GO:0048729 (tissue morphogenesis), GO:0060429 (epithelium development), GO:0002009 (morphogenesis of an epithelium), GO:0002011 (morphogenesis of an epithelial sheet)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)