Protein: Harvey rat sarcoma viral oncoprotein isoform A (X5D945)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004308}.
Sequence: MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
InterPro domains: - IPR001806: Small GTPase (family) [1-188]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-171]
- IPR005225: Small GTP-binding domain (domain) [1-159]
- IPR020849: Small GTPase, Ras-type (family) [3-166]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0019003 (GDP binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0005525 (GTP binding), GO:0019001 (guanyl nucleotide binding), GO:0032561 (guanyl ribonucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0034260 (negative regulation of GTPase activity), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:2000145 (regulation of cell motility), GO:0032388 (positive regulation of intracellular transport), GO:0009314 (response to radiation), GO:0080134 (regulation of response to stress), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0051726 (regulation of cell cycle), GO:0009887 (animal organ morphogenesis), GO:0098696 (regulation of neurotransmitter receptor localization to postsynaptic specialization membrane), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0071214 (cellular response to abiotic stimulus), GO:0090398 (cellular senescence), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:1902683 (regulation of receptor localization to synapse), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0044093 (positive regulation of molecular function), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0060341 (regulation of cellular localization), GO:0008285 (negative regulation of cell population proliferation), GO:0080135 (regulation of cellular response to stress), GO:0051130 (positive regulation of cellular component organization), GO:1903036 (positive regulation of response to wounding), GO:2000147 (positive regulation of cell motility), GO:0009891 (positive regulation of biosynthetic process), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051222 (positive regulation of protein transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:0070201 (regulation of establishment of protein localization), GO:0000165 (MAPK cascade), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0032956 (regulation of actin cytoskeleton organization), GO:0030334 (regulation of cell migration), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0060491 (regulation of cell projection assembly), GO:0051223 (regulation of protein transport), GO:0090303 (positive regulation of wound healing), GO:0030335 (positive regulation of cell migration), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0007264 (small GTPase mediated signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:0010212 (response to ionizing radiation), GO:0010629 (negative regulation of gene expression), GO:0032386 (regulation of intracellular transport), GO:0071478 (cellular response to radiation), GO:0043086 (negative regulation of catalytic activity), GO:0090316 (positive regulation of intracellular protein transport), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0031344 (regulation of cell projection organization), GO:1903034 (regulation of response to wounding), GO:0051336 (regulation of hydrolase activity), GO:0032880 (regulation of protein localization), GO:1905477 (positive regulation of protein localization to membrane), GO:0050679 (positive regulation of epithelial cell proliferation), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0031346 (positive regulation of cell projection organization), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0051338 (regulation of transferase activity), GO:0010638 (positive regulation of organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:2000251 (positive regulation of actin cytoskeleton reorganization), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0051493 (regulation of cytoskeleton organization), GO:1905475 (regulation of protein localization to membrane), GO:0051346 (negative regulation of hydrolase activity), GO:1900029 (positive regulation of ruffle assembly), GO:2000249 (regulation of actin cytoskeleton reorganization), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:1902473 (regulation of protein localization to synapse), GO:0043087 (regulation of GTPase activity), GO:0007265 (Ras protein signal transduction), GO:0043549 (regulation of kinase activity), GO:0090314 (positive regulation of protein targeting to membrane), GO:2000630 (positive regulation of miRNA metabolic process), GO:0060191 (regulation of lipase activity), GO:0043410 (positive regulation of MAPK cascade), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0051345 (positive regulation of hydrolase activity), GO:0031401 (positive regulation of protein modification process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0061041 (regulation of wound healing), GO:0043408 (regulation of MAPK cascade), GO:0051347 (positive regulation of transferase activity), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0031399 (regulation of protein modification process), GO:0071479 (cellular response to ionizing radiation), GO:0033157 (regulation of intracellular protein transport), GO:0006355 (regulation of DNA-templated transcription), GO:0010332 (response to gamma radiation), GO:0019220 (regulation of phosphate metabolic process), GO:2000628 (regulation of miRNA metabolic process), GO:1904375 (regulation of protein localization to cell periphery), GO:0051495 (positive regulation of cytoskeleton organization), GO:0070304 (positive regulation of stress-activated protein kinase signaling cascade), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0010517 (regulation of phospholipase activity), GO:0043547 (positive regulation of GTPase activity), GO:0045859 (regulation of protein kinase activity), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0043406 (positive regulation of MAP kinase activity), GO:0001934 (positive regulation of protein phosphorylation), GO:0060193 (positive regulation of lipase activity), GO:1900027 (regulation of ruffle assembly), GO:0032874 (positive regulation of stress-activated MAPK cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:1903533 (regulation of protein targeting), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0046328 (regulation of JNK cascade), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:0090313 (regulation of protein targeting to membrane), GO:0071480 (cellular response to gamma radiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0046330 (positive regulation of JNK cascade), GO:0010518 (positive regulation of phospholipase activity), GO:1900274 (regulation of phospholipase C activity), GO:0045860 (positive regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity), GO:0010863 (positive regulation of phospholipase C activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0005654 (nucleoplasm), GO:0071944 (cell periphery), GO:0031984 (organelle subcompartment), GO:0030054 (cell junction), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:1905360 (GTPase complex), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0098978 (glutamatergic synapse), GO:0005789 (endoplasmic reticulum membrane), GO:0070013 (intracellular organelle lumen), GO:0000139 (Golgi membrane), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)