Protein: Small ribosomal subunit protein eS8 (P62242)
Organism: Mus musculus (Mouse)
Function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)
Subcellular location: Cytoplasm. Membrane; Lipid-anchor. Nucleus, nucleolus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
Sequence: MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIVLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK
InterPro domains: - IPR001047: Small ribosomal subunit protein eS8 (family) [1-208]
- IPR018283: Small ribosomal subunit protein eS8, conserved site (conserved_site) [11-30]
- IPR042563: Small ribosomal subunit protein eS8 subdomain, eukaryota (homologous_superfamily) [108-169]
- IPR022309: Ribosomal protein eS8/ribosomal biogenesis NSA2 (family) [5-190]
Interaction partners: - Small ribosomal subunit protein uS9
- Large ribosomal subunit protein eL38
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein uL23
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL13
- Large ribosomal subunit protein uL30
- Large ribosomal subunit protein eL37
- Small ribosomal subunit protein uS14
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0030097 (hemopoiesis), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0048569 (post-embryonic animal organ development), GO:0048732 (gland development), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0010467 (gene expression), GO:0061008 (hepaticobiliary system development), GO:0043043 (peptide biosynthetic process), GO:0001889 (liver development), GO:0097421 (liver regeneration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)