Protein: Follicle-stimulating hormone receptor (FSH-R) (Follitropin receptor) (P79763)
Organism: Gallus gallus (Chicken)
Function: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P23945}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23945}.
Sequence: MSLGLTCLLILLASCSGCQHHTCLCEGRIFICQEIKVVQLPRDIPTNATELRFVLTKMRVIPKGAFTGLHDLEKIEISQNDALEIIEGNVFSSLPKLHEIRIEKANKLMKIDQDAFQHLPSLRYLLISNTGLSFLPVVHKVHSFQKVLLDVQDNIHIRTIERNTFMGLSSESVILRLNKNGIQEIKDHAFNGTCLDELNLSDNYNLEKLPEKVFQGAIGPVVLDISRTRISFLPSHGLEFIKKLRARSTYKLKKLPDVNKFRSLIEANFTYPSHCCAFTNRKTQNTEFYPICSMSPAKQDLGEQTGKRKHRRSAAEDYISHYGTRFGPVENEFDYGLCNEVVDFVCSPKPDAFNPCEDIMGYNVLRVLIWFINILAITGNTTVLIILISSQYKLTVPRFLMCNLAFADLCIGIYLLFIASVDIQTKSRYYNYAIDWQTGAGCNAAGFFTVFASELSVYTLTVITLERWHTITYAMQLNRKVRLRHAVIIMVFGWMFAFTVALLPIFGISSYMKVSICLPMHIETPFSQAYVIFLLVLNVLAFVIICICYICIYFTVRNPNVISSNSDTKIAKRMAILIFTDFLCMAPISFFAISASLRVPLITVSKSKILLVLFYPINSCANPFLYAIFTKTFRRDFFILLSKFGCCEMQAQIYRTETSSSAHNFHTRNGHYPTASKNSDGTIYSLVPLNHLN
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [17-364]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [364-634]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [379-626]
- IPR002272: Follicle stimulating hormone receptor (family) [3-672]
- IPR024635: Gonadotropin hormone receptor, transmembrane domain (domain) [282-349]
- IPR001611: Leucine-rich repeat (repeat) [57-104]
- IPR002131: Glycoprotein hormone receptor family (family) [353-648]
- IPR026906: BspA-type LRR region (repeat) [157-215]
Interaction partners: - Follitropin subunit beta
- Glycoprotein hormones alpha chain
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Aromatase
- TGF_BETA_2 domain-containing protein.
- Steroidogenic acute regulatory protein, mitochondrial
- Growth/differentiation factor 9
- TGF_BETA_2 domain-containing protein.
- 3Beta_HSD domain-containing protein.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0016500 (protein-hormone receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0022602 (ovulation cycle process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0042698 (ovulation cycle), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0046660 (female sex differentiation), GO:0007276 (gamete generation), GO:0009967 (positive regulation of signal transduction), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0007283 (spermatogenesis), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0010647 (positive regulation of cell communication), GO:0001541 (ovarian follicle development), GO:0007548 (sex differentiation), GO:0046661 (male sex differentiation), GO:0061458 (reproductive system development), GO:0071310 (cellular response to organic substance), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0032870 (cellular response to hormone stimulus), GO:0046545 (development of primary female sexual characteristics), GO:0007292 (female gamete generation), GO:0034698 (response to gonadotropin), GO:1902533 (positive regulation of intracellular signal transduction), GO:0048232 (male gamete generation), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling), GO:0008585 (female gonad development), GO:0010738 (regulation of protein kinase A signaling), GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling), GO:0008584 (male gonad development), GO:0071371 (cellular response to gonadotropin stimulus), GO:0043410 (positive regulation of MAPK cascade), GO:0032354 (response to follicle-stimulating hormone), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0071372 (cellular response to follicle-stimulating hormone stimulus), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)