Protein: Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) (Q6VVW5)
Organism: Mus musculus (Mouse)
Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20594}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20594}.
Sequence: MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQKGPPGLL
InterPro domains: - IPR050401: Cyclic nucleotide synthase (family) [93-1038]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [533-826]
- IPR018297: Adenylyl cyclase class-4/guanylyl cyclase, conserved site (conserved_site) [968-991]
- IPR001170: Adenylyl cyclase class-4/guanylyl cyclase (family) [97-480]
- IPR029787: Nucleotide cyclase (homologous_superfamily) [817-1042]
- IPR001828: Receptor, ligand binding region (domain) [45-397]
- IPR001054: Adenylyl cyclase class-3/4/guanylyl cyclase (domain) [825-1037]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [540-783]
- IPR000719: Protein kinase domain (domain) [513-786]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [24-441]
Interaction partners: - Natriuretic peptides A
- C-type natriuretic peptide
- Natriuretic peptides B
- Atrial natriuretic peptide receptor 1
- Bis
- Inosine triphosphate pyrophosphatase
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
- cGMP-specific 3',5'-cyclic phosphodiesterase
- Molybdenum cofactor biosynthesis protein 1
- GTP cyclohydrolase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0009975 (cyclase activity), GO:0004383 (guanylate cyclase activity), GO:0016849 (phosphorus-oxygen lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0003008 (system process), GO:0008217 (regulation of blood pressure), GO:0003013 (circulatory system process), GO:0008015 (blood circulation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)