Protein: ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1) (P9WPH9)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1-275]
- IPR000641: CbxX/CfxQ (family) [289-529]
- IPR003593: AAA+ ATPase domain (domain) [326-467]
- IPR003959: ATPase, AAA-type, core (domain) [330-464]
- IPR050773: CbxX/CfxQ RuBisCO activation and ESX secretion (family) [31-568]
- IPR041627: CbbX, AAA lid domain (domain) [498-557]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [276-547]
- IPR049078: ESX-1 secretion system protein EccA1-like, N-terminal domain (domain) [2-272]
- IPR023835: Type VII secretion system AAA-ATPase, EccA (family) [27-566]
Interaction partners: - ESX-1 secretion-associated protein EspH
- ESX-1 secretion-associated protein EspG1
- ESX-1 secretion system protein EccCa1
- ESX-1 secretion system ATPase EccB1
- ESX-1 secretion-associated protein EspF
- ESX-1 secretion system protein EccCb1
- ESX-1 secretion-associated protein EspE
- ESAT-6-like protein EsxB
- FHA domain-containing protein
- PPE family immunomodulator PPE68
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016887 (ATP hydrolysis activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0050801 (monoatomic ion homeostasis), GO:0009991 (response to extracellular stimulus), GO:0055082 (intracellular chemical homeostasis), GO:0042594 (response to starvation), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0098771 (inorganic ion homeostasis), GO:0031668 (cellular response to extracellular stimulus), GO:0071496 (cellular response to external stimulus), GO:0098657 (import into cell), GO:0055080 (monoatomic cation homeostasis), GO:0033212 (iron import into cell), GO:0009267 (cellular response to starvation), GO:0006882 (intracellular zinc ion homeostasis), GO:0031667 (response to nutrient levels), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0031669 (cellular response to nutrient levels), GO:0006811 (monoatomic ion transport), GO:0055072 (iron ion homeostasis), GO:0006812 (monoatomic cation transport), GO:0010106 (cellular response to iron ion starvation), GO:0033214 (siderophore-dependent iron import into cell), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport), GO:1901678 (iron coordination entity transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)