Protein: Sodium-coupled neutral amino acid symporter 2 (Amino acid transporter A2) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2) (Q9JHE5)
Organism: Rattus norvegicus (Rat)
Function: Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane. The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier. May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate. Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:11311116, ECO:0000269|PubMed:11834730, ECO:0000269|PubMed:12054432, ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:19589777, ECO:0000269|PubMed:21158741, ECO:0000269|PubMed:27355203, ECO:0000269|PubMed:29678469, ECO:0000305|PubMed:10859363}; Multi-pass membrane protein {ECO:0000269|PubMed:17488712, ECO:0000269|PubMed:29678469}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (PubMed:11834730). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal (PubMed:15561425, PubMed:16616430, PubMed:18832333). {ECO:0000269|PubMed:11834730, ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430, ECO:0000269|PubMed:18832333}.
Sequence: MKKTEMGRFNISPDEDSSSYSSNGDFNYSYPTKQAALKSHYVDVDPENQNFLLESNLGKKKYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIKALMNIEDTNGLWYLNGDYLVLLVSFVLILPLSLLRNLGYLGYTSGLSLLCMIFFLIVVICKKFQIPCPVEVALMANETVNGTFTQVALAALASNSTAADTCRPRYFIFNSQTVYAVPILTFSFVCHPAVLPIYEELKSRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSAIVGTDILLLVVRLAVLVAVTLTVPVVIFPIRSSVTHLLCPTKEFSWFRHSVITVTILAFTNLLVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKEPMRSVQKIGALCFLLSGVVVMIGSMGLIVLDWVHDASAGGH
InterPro domains: - IPR013057: Amino acid transporter, transmembrane domain (domain) [70-491]
Interaction partners: - Sodium-coupled neutral amino acid symporter 1
- Amino acid transporter
- Neutral amino acid transporter B
- Serotonin N-acetyltransferase
- Large neutral amino acids transporter small subunit 1
- Large neutral amino acids transporter small subunit 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901474 (azole transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0005343 (organic acid:sodium symporter activity), GO:0015297 (antiporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005283 (amino acid:sodium symporter activity), GO:0015293 (symporter activity), GO:0140828 (metal cation:monoatomic cation antiporter activity), GO:0015078 (proton transmembrane transporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0015370 (solute:sodium symporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015385 (sodium:proton antiporter activity), GO:0015173 (aromatic amino acid transmembrane transporter activity), GO:0015174 (basic amino acid transmembrane transporter activity), GO:0015179 (L-amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity), GO:0051139 (metal cation:proton antiporter activity), GO:0005416 (amino acid:monoatomic cation symporter activity), GO:0015186 (L-glutamine transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0010035 (response to inorganic substance), GO:1903825 (organic acid transmembrane transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0080134 (regulation of response to stress), GO:0006810 (transport), GO:0080135 (regulation of cellular response to stress), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0046685 (response to arsenic-containing substance), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0006836 (neurotransmitter transport), GO:0051254 (positive regulation of RNA metabolic process), GO:0071705 (nitrogen compound transport), GO:0071243 (cellular response to arsenic-containing substance), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0071702 (organic substance transport), GO:0010628 (positive regulation of gene expression), GO:0051252 (regulation of RNA metabolic process), GO:1905039 (carboxylic acid transmembrane transport), GO:1901701 (cellular response to oxygen-containing compound), GO:0010468 (regulation of gene expression), GO:0033120 (positive regulation of RNA splicing), GO:0015711 (organic anion transport), GO:0043484 (regulation of RNA splicing), GO:0003333 (amino acid transmembrane transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0046942 (carboxylic acid transport), GO:0015804 (neutral amino acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)