Protein: Cytokine receptor-like factor 2 (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor) (Type I cytokine receptor delta 1) (Q8CII9)
Organism: Mus musculus (Mouse)
Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.
Subcellular location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
Sequence: MAWALAVILLPRLLAAAAAAAAVTSRGDVTVVCHDLETVEVTWGSGPDHHGANLSLEFRYGTGALQPCPRYFLSGAGVTSGCILPAARAGLLELALRDGGGAMVFKARQRASAWLKPRPPWNVTLLWTPDGDVTVSWPAHSYLGLDYEVQHRESNDDEDAWQTTSGPCCDLTVGGLDPARCYDFRVRASPRAAHYGLEAQPSEWTAVTRLSGAASAASCTASPAPSPALAPPLLPLGCGLAALLTLSLLLAALRLRRVKDALLPCVPDPSGSFPGLFEKHHGNFQAWIADAQATAPPARTEEEDDLIHPKAKRVEPEDGTSLCTVPRPPSFEPRGPGGGAMVSVGGATFMVGDSGYMTL
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [29-208]
- IPR003961: Fibronectin type III (domain) [117-213]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [20-225]
- IPR053856: Cytokine receptor-like factor 2-like, domain 1 (domain) [29-106]
- IPR048648: Cytokine receptor-like factor 2-like, D2 domain (domain) [117-211]
Interaction partners: - Thymic stromal lymphopoietin
- Interleukin-7 receptor subunit alpha
- Tyrosine-protein kinase JAK2
- Interleukin-33
- Interleukin-7
- Interleukin-4
- Interleukin-13
- Interleukin-5
- Tyrosine-protein kinase JAK3
- Interleukin-9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0008047 (enzyme activator activity), GO:0140375 (immune receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0048522 (positive regulation of cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009967 (positive regulation of signal transduction), GO:0002696 (positive regulation of leukocyte activation), GO:0042127 (regulation of cell population proliferation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0002694 (regulation of leukocyte activation), GO:0010647 (positive regulation of cell communication), GO:0001819 (positive regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:0050865 (regulation of cell activation), GO:0010033 (response to organic substance), GO:0050867 (positive regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0034097 (response to cytokine), GO:0071310 (cellular response to organic substance), GO:0033003 (regulation of mast cell activation), GO:0010628 (positive regulation of gene expression), GO:1904894 (positive regulation of receptor signaling pathway via STAT), GO:1904892 (regulation of receptor signaling pathway via STAT), GO:0019221 (cytokine-mediated signaling pathway), GO:0033005 (positive regulation of mast cell activation), GO:0010468 (regulation of gene expression), GO:0032674 (regulation of interleukin-5 production), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)