Protein: Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand) (Growth-potentiating factor) (GPF) (Q63772)
Organism: Rattus norvegicus (Rat)
Function: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses (By similarity).
Subcellular location: Secreted {ECO:0000269|PubMed:7559388}.
Sequence: MPPPPGPTAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETDYFYPRYQECMRKYGRPEDKNPNFATCVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQKNGGCSQVCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKNLPGSYSCLCDKGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELDRNLVIKVNKDAVMKIAVAGGLFQLERGLYHLNLTVGGIPFKESDLVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEVEVVARIRPATDTGVLMALVGDKDVVLLSVALVDYHSTKKLKKQLVVLAVENVALALMEIKVCDSQEHTVTVSLRDGEATLEVDGTKGQSEVSTAQLQERLDLLKTRLQGSVLTFVGGLPDVQVTSTPVTAFYRGCMTLEVNGKTLDLDTASYKHSDITSHSCPPVEHVTA
InterPro domains: - IPR001881: EGF-like calcium-binding domain (domain) [115-275]
- IPR051145: Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent (family) [113-667]
- IPR001791: Laminin G domain (domain) [295-666]
- IPR017857: Coagulation factor-like, Gla domain superfamily (homologous_superfamily) [46-91]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [258-669]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [194-257]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [130-259]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [194-260]
- IPR035972: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily (homologous_superfamily) [46-103]
- IPR000742: EGF-like domain (domain) [113-275]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [109-235]
- IPR000294: Gamma-carboxyglutamic acid-rich (GLA) domain (domain) [26-91]
Interaction partners: - Tyrosine-protein kinase Mer
- Tyrosine-protein kinase receptor UFO
- Tyrosine-protein kinase receptor TYRO3
- Vitamin K-dependent protein S
- Furin
- Galectin-3
- Tubby-like protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0051050 (positive regulation of transport), GO:0051707 (response to other organism), GO:0050818 (regulation of coagulation), GO:0051049 (regulation of transport), GO:0043207 (response to external biotic stimulus), GO:0050819 (negative regulation of coagulation), GO:0009611 (response to wounding), GO:0048731 (system development), GO:0009617 (response to bacterium), GO:0048513 (animal organ development), GO:0050766 (positive regulation of phagocytosis), GO:0060627 (regulation of vesicle-mediated transport), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0050764 (regulation of phagocytosis), GO:0032496 (response to lipopolysaccharide), GO:0033993 (response to lipid), GO:0048732 (gland development), GO:0002237 (response to molecule of bacterial origin), GO:0061008 (hepaticobiliary system development), GO:0048678 (response to axon injury), GO:0001889 (liver development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)