Protein: Nuclear receptor ROR-beta (Nuclear receptor RZR-beta) (Nuclear receptor subfamily 1 group F member 2) (Retinoid-related orphan receptor-beta) (Q8R1B8)
Organism: Mus musculus (Mouse)
Function: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity.
Subcellular location: Nucleus {ECO:0000269|PubMed:16574740}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q92753}.
Sequence: MCENQPKTKADGTAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNTETGGTYANGHVIDLPKSEGYYSIDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMSEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPDIVNTLFPPLYKELFNPDCAAVCK
InterPro domains: - IPR035500: Nuclear hormone receptor-like domain superfamily (homologous_superfamily) [213-467]
- IPR044101: Retinoid-related orphan receptors, DNA-binding domain (domain) [14-108]
- IPR001628: Zinc finger, nuclear hormone receptor-type (domain) [18-93]
- IPR000536: Nuclear hormone receptor, ligand-binding domain (domain) [222-460]
- IPR003079: Nuclear receptor ROR (family) [208-456]
- IPR001723: Nuclear hormone receptor (family) [82-436]
- IPR013088: Zinc finger, NHR/GATA-type (homologous_superfamily) [13-124]
Interaction partners: - Nuclear receptor coactivator 1
- Nuclear receptor ROR-alpha
- Nuclear receptor ROR-gamma
- Basic helix-loop-helix ARNT-like protein 1
- Nuclear receptor corepressor 1
- Nuclear receptor corepressor 2
- Period circadian protein homolog 3
- Cryptochrome-1
- Circadian locomoter output cycles protein kaput
- Cone-rod homeobox protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0008013 (beta-catenin binding), GO:0003676 (nucleic acid binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0001221 (transcription coregulator binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0001223 (transcription coactivator binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0001775 (cell activation), GO:0042752 (regulation of circadian rhythm), GO:0019222 (regulation of metabolic process), GO:0007623 (circadian rhythm), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0044238 (primary metabolic process), GO:0042753 (positive regulation of circadian rhythm), GO:0048522 (positive regulation of cellular process), GO:0061351 (neural precursor cell proliferation), GO:0002250 (adaptive immune response), GO:0055088 (lipid homeostasis), GO:0002366 (leukocyte activation involved in immune response), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009410 (response to xenobiotic stimulus), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:0006725 (cellular aromatic compound metabolic process), GO:0006805 (xenobiotic metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0046649 (lymphocyte activation), GO:0021680 (cerebellar Purkinje cell layer development), GO:0021696 (cerebellar cortex morphogenesis), GO:0006793 (phosphorus metabolic process), GO:0021549 (cerebellum development), GO:1901360 (organic cyclic compound metabolic process), GO:2001057 (reactive nitrogen species metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0021587 (cerebellum morphogenesis), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0021575 (hindbrain morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0021692 (cerebellar Purkinje cell layer morphogenesis), GO:0019637 (organophosphate metabolic process), GO:0030902 (hindbrain development), GO:0021695 (cerebellar cortex development), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0022037 (metencephalon development), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0021697 (cerebellar cortex formation), GO:0006139 (nucleobase-containing compound metabolic process), GO:0060322 (head development), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0045596 (negative regulation of cell differentiation), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0021694 (cerebellar Purkinje cell layer formation), GO:0002263 (cell activation involved in immune response), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0032922 (circadian regulation of gene expression), GO:0045598 (regulation of fat cell differentiation), GO:0021533 (cell differentiation in hindbrain), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010675 (regulation of cellular carbohydrate metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0007420 (brain development), GO:0007399 (nervous system development), GO:0055092 (sterol homeostasis), GO:0055090 (acylglycerol homeostasis), GO:0019693 (ribose phosphate metabolic process), GO:0007417 (central nervous system development), GO:0051252 (regulation of RNA metabolic process), GO:0045599 (negative regulation of fat cell differentiation), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0006753 (nucleoside phosphate metabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0002521 (leukocyte differentiation), GO:0043030 (regulation of macrophage activation), GO:0071310 (cellular response to organic substance), GO:0021702 (cerebellar Purkinje cell differentiation), GO:0010906 (regulation of glucose metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0006109 (regulation of carbohydrate metabolic process), GO:0008589 (regulation of smoothened signaling pathway), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0042110 (T cell activation), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0019216 (regulation of lipid metabolic process), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0046209 (nitric oxide metabolic process), GO:0002285 (lymphocyte activation involved in immune response), GO:0002286 (T cell activation involved in immune response), GO:0009117 (nucleotide metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0071345 (cellular response to cytokine stimulus), GO:0009259 (ribonucleotide metabolic process), GO:1903131 (mononuclear cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:0070328 (triglyceride homeostasis), GO:0019218 (regulation of steroid metabolic process), GO:0030217 (T cell differentiation), GO:0070555 (response to interleukin-1), GO:0021953 (central nervous system neuron differentiation), GO:0006355 (regulation of DNA-templated transcription), GO:0006809 (nitric oxide biosynthetic process), GO:0034612 (response to tumor necrosis factor), GO:0006163 (purine nucleotide metabolic process), GO:0046631 (alpha-beta T cell activation), GO:0042632 (cholesterol homeostasis), GO:0009150 (purine ribonucleotide metabolic process), GO:0009187 (cyclic nucleotide metabolic process), GO:0002292 (T cell differentiation involved in immune response), GO:0052652 (cyclic purine nucleotide metabolic process), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0002287 (alpha-beta T cell activation involved in immune response), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0035710 (CD4-positive, alpha-beta T cell activation), GO:0046632 (alpha-beta T cell differentiation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071347 (cellular response to interleukin-1), GO:0071356 (cellular response to tumor necrosis factor), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0046068 (cGMP metabolic process), GO:0043367 (CD4-positive, alpha-beta T cell differentiation), GO:0002293 (alpha-beta T cell differentiation involved in immune response), GO:0002294 (CD4-positive, alpha-beta T cell differentiation involved in immune response), GO:0042093 (T-helper cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)