Protein: Histone-lysine N-methyltransferase SUVR5 (EC 2.1.1.-) (C2H2 zinc finger-SET histone methyltransferase) (Protein C2H2 SET) (Protein SET DOMAIN GROUP 6) (Suppressor of variegation 3-9-related protein 5) (Su(var)3-9-related protein 5) (O64827)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Histone methyltransferase that functions together with its binding partner LDL1/SWP1 as one of the regulators of flower timing in Arabidopsis. Mediates H3K9me2 deposition and regulates gene expression in a DNA methylation-independent manner. Binds DNA through its zinc fingers and represses the expression of a subset of stimulus response genes. May represent a novel mechanism for plants to regulate their chromatin and transcriptional state, which may allow for the adaptability and modulation necessary to rapidly respond to environment or developmental cues.
Subcellular location: Nucleus {ECO:0000269|PubMed:17224141}. Chromosome {ECO:0000250|UniProtKB:Q5DW34}. Note=Associates with euchromatic regions. {ECO:0000250|UniProtKB:Q5DW34}.
Sequence: MEVKMDELVLDVDVEEATGSELLVKSEPEADLNAVKSSTDLVTVTGPIGKNGEGESSPSEPKWLQQDEPIALWVKWRGKWQAGIRCAKADWPLTTLRGKPTHDRKKYCVIFFPHTKNYSWADMQLVRSINEFPDPIAYKSHKIGLKLVKDLTAARRYIMRKLTVGMFNIVDQFPSEVVSEAARDIIIWKEFAMEATRSTSYHDLGIMLVKLHSMILQRYMDPIWLENSFPLWVQKCNNAVNAESIELLNEEFDNCIKWNEVKSLSESPMQPMLLSEWKTWKHDIAKWFSISRRGVGEIAQPDSKSVFNSDVQASRKRPKLEIRRAETTNATHMESDTSPQGLSAIDSEFFSSRGNTNSPETMKEENPVMNTPENGLDLWDGIVVEAGGSQFMKTKETNGLSHPQDQHINESVLKKPFGSGNKSQQCIAFIESKGRQCVRWANEGDVYCCVHLASRFTTKSMKNEGSPAVEAPMCGGVTVLGTKCKHRSLPGFLYCKKHRPHTGMVKPDDSSSFLVKRKVSEIMSTLETNQCQDLVPFGEPEGPSFEKQEPHGATSFTEMFEHCSQEDNLCIGSCSENSYISCSEFSTKHSLYCEQHLPNWLKRARNGKSRIISKEVFVDLLRGCLSREEKLALHQACDIFYKLFKSVLSLRNSVPMEVQIDWAKTEASRNADAGVGEFLMKLVSNERERLTRIWGFATGADEEDVSLSEYPNRLLAITNTCDDDDDKEKWSFSGFACAICLDSFVRRKLLEIHVEERHHVQFAEKCMLLQCIPCGSHFGDKEQLLVHVQAVHPSECKSLTVASECNLTNGEFSQKPEAGSSQIVVSQNNENTSGVHKFVCKFCGLKFNLLPDLGRHHQAEHMGPSLVGSRGPKKGIRFNTYRMKSGRLSRPNKFKKSLGAVSYRIRNRAGVNMKRRMQGSKSLGTEGNTEAGVSPPLDDSRNFDGVTDAHCSVVSDILLSKVQKAKHRPNNLDILSAARSACCRVSVETSLEAKFGDLPDRIYLKAAKLCGEQGVQVQWHQEGYICSNGCKPVKDPNLLHPLIPRQENDRFGIAVDAGQHSNIELEVDECHCIMEAHHFSKRPFGNTAVLCKDISFGKESVPICVVDDDLWNSEKPYEMPWECFTYVTNSILHPSMDLVKENLQLRCSCRSSVCSPVTCDHVYLFGNDFEDARDIYGKSMRCRFPYDGKQRIILEEGYPVYECNKFCGCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVLDQQEANKRRNQYGNGDCSYILDIDANINDIGRLMEEELDYAIDATTHGNISRFINHSCSPNLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPSEQENEHPCHCKATNCRGLLS
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [735-866]
- IPR046341: SET domain superfamily (homologous_superfamily) [1079-1382]
- IPR001214: SET domain (domain) [1224-1362]
- IPR040689: SUVR5, C2H2-type Zinc finger, 3 repeats (repeat) [737-862]
- IPR003616: Post-SET domain (domain) [1366-1382]
- IPR007728: Pre-SET domain (domain) [1091-1221]
Interaction partners: - Polycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM
- Lysine-specific demethylase ELF6
- Histone H4
- Ubiquitin-ribosomal protein eL40z fusion protein
- Ubiquitin-ribosomal protein eL40y fusion protein
- Histone-binding protein MSI1
- WD-40 repeat-containing protein MSI4
- Multiple organellar RNA editing factor 1, mitochondrial
- WD-40 repeat-containing protein MSI5
- WD-40 repeat-containing protein MSI3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0043414 (macromolecule methylation), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0018205 (peptidyl-lysine modification), GO:0070734 (histone H3-K27 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0055044 (symplast), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005911 (cell-cell junction), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)