Protein: Focal adhesion kinase 1 (Q7T2V4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, cilium basal body
Sequence: MATAFLEPTPNHTLSVGAKARLSAGTERVPGAPDRVLKVFHHFENNSEHSTWSSNIRHGDATDVRGIIQKIVDIHKVQHVVCFGLRLTHVPSGDVHWLHPDEGVSHVREKFEQKRPQDEWRYELRIRYLPKGFLTQFTEDKPTLNYFYQQVKNDYMLEVADQVEQEVALKLGCLEIRRFYREMRGNALDKKSNYELLEKDVGLRRFFPKSLLESVKAKTLRKQIQQTFKQFANLNDEQSVLKFFEILAPVYRFDKECFRCALGSSWVISVDLAIGPEEGISYLTDKGSTPTHLANLTQVQSIHYSCVEEKERKGVLQLDVAGAAEPLTISTPSFSTAENMADLIDGYCRLLNAVNQSFIIRPQKDGERALPSIPKLANNEKRLEGIRAGVRAISVSETDDYAEIIDEEDTYTMPSTQDYEIQRDRIELGRCIGEGQFGDVHQGVYISPENPSLSVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGIITENPVWIIMELCTLGELRSFLQVRKYNLDLSTLILFAYQLSTALAYLESKRFVHRDIAARNVLVSSIDCVKLGDFGLSRYMEDSSYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMFGIKPFQGVKNNDVIGRIENGERLAMPQNCPPTLYSLMTKCWAYDPSKRPRFTELKTQLSTILDEEKLQQEERFRMEMRRQVTVSWDAGNSDEAPPKPSRPGYPSPRSSDGYFPSPQHAGQHNHYQGSGYPAAHVSSPGFPAQTSILDPLESWNHRQEPPTWPANAEDGAAVGRTQPMNTHLMEETLIKQQQQMEEDQRWLEQEESFLKPESRNSRSSIDREDAALQTPMGKQHVYQPVGKTDLVAPPKKPPRPGAPAHLTNLSPADSYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSRIQPALPEEYVPMVKDVGLALRTLLATVDETIPVLPAHTHREIEMAQKLLNSDLAELISKMRLAQQYMLTSLQQDYKKQMLTAAHALAVDAKNLLDVIYQARLKMSHRTH
InterPro domains: - IPR008266: Tyrosine-protein kinase, active site (active_site) [546-558]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [253-371]
- IPR049385: FAK1-like, FERM domain C-lobe (domain) [260-357]
- IPR000299: FERM domain (domain) [37-355]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [426-680]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [32-130]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [413-707]
- IPR036137: Focal adhesion kinase, targeting (FAT) domain superfamily (homologous_superfamily) [903-1042]
- IPR019748: FERM central domain (domain) [137-248]
- IPR041390: Focal adhesion kinase, N-terminal (domain) [35-130]
- IPR041784: FAK1/PYK2, FERM domain C-lobe (domain) [254-364]
- IPR017441: Protein kinase, ATP binding site (binding_site) [432-458]
- IPR019749: Band 4.1 domain (domain) [31-258]
- IPR000719: Protein kinase domain (domain) [426-684]
- IPR035963: FERM superfamily, second domain (homologous_superfamily) [132-253]
- IPR005189: Focal adhesion kinase, targeting (FAT) domain (domain) [909-1040]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [128-252]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [426-680]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0016301 (kinase activity), GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0002088 (lens development in camera-type eye), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0003002 (regionalization), GO:0030154 (cell differentiation), GO:0060322 (head development), GO:0002089 (lens morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0030917 (midbrain-hindbrain boundary development), GO:0009790 (embryo development), GO:0007420 (brain development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0002064 (epithelial cell development), GO:0021915 (neural tube development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0007417 (central nervous system development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0070306 (lens fiber cell differentiation), GO:0021532 (neural tube patterning), GO:0060429 (epithelium development), GO:0009952 (anterior/posterior pattern specification), GO:0030855 (epithelial cell differentiation), GO:0043009 (chordate embryonic development), GO:0048592 (eye morphogenesis), GO:0070307 (lens fiber cell development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0021903 (rostrocaudal neural tube patterning), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005886 (plasma membrane), GO:0070161 (anchoring junction), GO:0042383 (sarcolemma), GO:0005911 (cell-cell junction)