Protein: Genome polyprotein (Q9E7P0)
Organism: dengue virus type 2
Function: Not known
Subcellular location: Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004153}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004461}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004461}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004461}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00023443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00023443}; Lumenal side {ECO:0000256|ARBA:ARBA00023443}. Host mitochondrion {ECO:0000256|ARBA:ARBA00004181}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Virion membrane {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004385}.
Sequence: MNNQRKKARSTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIPPTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGVIVMLIPTAMAFHLTTRNGEPHMIVGRQEKGKSLLFKTEDGVNMCTLMAIDLGELCEDTITYKCPFLRQNEPEDIDCWCNFTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHVQRIETWILRHPGFTIMAAILAYTIGTTHFQRALIFILLTAVAPSMTMRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFICKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEEHAVGNDTGKHGKEIKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMEDKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKIVKEIAETQHGTIVIRVQYEGDGSPCKIPFEITDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGVVTLYLGAMVQADSGCVVSWKNKELKCGSGIFITDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQPTELKYSWKTWGKAKMLSTESHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLKLREKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKMEKASFIEVKSCHWPKSHTLWSNGVLESEMIIPKNFAGPVSQHNYRPGYHTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTAGHGQIDNFSLGVLGMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVTYLALLAAFKVRPTFAAGLLLRKLTSKELMMATIGIALLSQSTMPETILELTDALALGMMVLKIVRNMEKYQLAVTIMAISCVPNAVILQNAWKVSCTILAAVSVSPLLLTSSQQKADWIPLALTIKGLNPTAIFLTTLSRTSKKRSWPLNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGVFPVSIPITAAAWYLWEVKKQRAGVLWDVPSPPPVGKAELEDGAYRIKQRGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHRGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGIFKTNTGTIGAVSLDFSPGTSGSPIVDRKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRKKRLTIMDLHPGAGKTKRYLPAIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPFPQSNAPIMDEEREIPERSWNSGHEWVTDFKGKTVWFVPSIKAGNDIAACLRKNGKKVIQLSRKTFDSEYVKTRANDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAGPMPVTHSSAAQRRGRIGRNPKNENDQYIYMGEPLENDEDCAHWKEAKMLLDNINTPEGIIPSMFEPEREKVDAIDGEYRLRGEARKTFVDLMRRGDLPVWLAYKVAAEGINYADRKWCFDGIKNNQILEENVEVEIWTKEGERKKLKPRWLDARIYSDPLALKEFKEFAAGRKSLTLNLITEMGRLPTFMTQKARNALDNLAVLHTAEAGGRAYNHALSELPETLETLLLLTLLATVTGGIFLFLMSGKGIGKMTLGMCCIITASSLLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQRTPQDNQLTYVVIAILTVVAATMANEMGFLEKTKKDLGLGSIATQESESNILDIDLRPASAWTLYAVATTFVTPMLRHSIENSSVNVSLTAIANQATVLMGLGKGWPLSKMDIGVPLLAIGCYSQVNPITLTAALLLLVAHYAIIGPGLQAKATREAQKRAAAGIMKNPTVDGITVIDLEPIPYDPKFEKQLGQVMLLILCVTQVLMMRTTWALCEALTLATGPISTLWEGNPGRFWNTTIAVSMANIFRGSYLAGAGLLFSIMKNTTNTRRGTGNIGETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNMVTPEGKVVDLGCGRGGWSYYCGGLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTIEAGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMETLQRKYGGALVRNPLSRNSTHEMYWVSNATGNIVSSVNMISRMLINRFTMKHKKATYEPDVDLGSGTRNIGIESEIPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREAVEDGRFWELVDRERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRGNSLSGVEGEGLHRLGYILREVGKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMKGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGIFKSIQHLTATEEIAVQNWLARVGRERLSRMAISGDDCVVKPIDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELVMKDGRVLVVPCRNQDELIGRARISQGAGWSLKETACLGKSYAQMWTLMYFHKRDLRLAANAICSAVPSHWVPTSRTTWSIHAKHEWMTTEDMLAVWNRVWIQENPWMEDKTPVESWEEVPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
InterPro domains: - IPR001528: Flavivirus non-structural protein NS4B (domain) [2244-2484]
- IPR011998: Envelope glycoprotein E, central and dimerisation domain, flavivirus (domain) [282-576]
- IPR000208: RNA-directed RNA polymerase, fingers/palm subdomains, flavivirus (domain) [2742-3191]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [1531-1657]
- IPR013756: Flaviviral glycoprotein E, central domain, subdomain 2 (homologous_superfamily) [332-547]
- IPR000752: Flavivirus non-structural protein NS2A (domain) [1138-1328]
- IPR001122: Capsid protein C, flavivirus (domain) [5-111]
- IPR001650: Helicase, C-terminal domain-like (domain) [1821-1988]
- IPR001157: Non-structural protein NS1, flavivirus (domain) [777-1129]
- IPR011492: Non-structural protein NS3-like, DEAD-box helicase, flavivirus (domain) [1658-1805]
- IPR000069: Envelope glycoprotein M, flavivirus (domain) [207-279]
- IPR013755: Flaviviral glycoprotein E, central domain, subdomain 1 (homologous_superfamily) [342-535]
- IPR014001: Helicase superfamily 1/2, ATP-binding domain (domain) [1628-1829]
- IPR007094: RNA-directed RNA polymerase, catalytic domain (domain) [3019-3168]
- IPR002535: Flavivirus polyprotein propeptide (domain) [120-204]
- IPR000487: Non-structural protein NS2B, flavivirus (domain) [1346-1475]
- IPR001850: Non-structural protein NS3, peptidase S7, flavivirus (domain) [1476-1653]
- IPR000404: Flavivirus non-structural protein NS4A (domain) [2099-2240]
- IPR002877: Ribosomal RNA methyltransferase, FtsJ domain (domain) [2546-2713]
- IPR000336: Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily (homologous_superfamily) [574-678]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0016032 (viral process), GO:0044068 (modulation by symbiont of host cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0035821 (modulation of process of another organism), GO:0019048 (modulation by virus of host process), GO:0044403 (biological process involved in symbiotic interaction), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0051701 (biological process involved in interaction with host), GO:0052040 (modulation by symbiont of host programmed cell death), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0044003 (modulation by symbiont of host process), GO:0031323 (regulation of cellular metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0019054 (modulation by virus of host cellular process), GO:0010508 (positive regulation of autophagy), GO:0043067 (regulation of programmed cell death), GO:0010506 (regulation of autophagy), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0039713 (viral factory), GO:0033655 (host cell cytoplasm part), GO:0039714 (cytoplasmic viral factory), GO:0030430 (host cell cytoplasm)