Protein: Alpha-1D adrenergic receptor (Alpha-1A adrenergic receptor) (Alpha-1D adrenoreceptor) (Alpha-1D adrenoceptor) (Alpha-adrenergic receptor 1a) (P25100)
Organism: Homo sapiens (Human)
Function: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
InterPro domains: - IPR002233: Adrenoceptor family (family) [151-417]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [113-402]
- IPR000363: Alpha 1D adrenoceptor (family) [3-568]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [98-417]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit alpha-11
- Guanine nucleotide-binding protein subunit alpha-13
- Guanine nucleotide-binding protein subunit alpha-12
- Alpha-1B adrenergic receptor
- Alpha-1A adrenergic receptor
- Beta-2-syntrophin
- Beta-1-syntrophin
- Utrophin
- Thromboxane A2 receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity), GO:0004930 (G protein-coupled receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0004935 (adrenergic receptor activity), GO:0004936 (alpha-adrenergic receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0003012 (muscle system process), GO:0009967 (positive regulation of signal transduction), GO:0012501 (programmed cell death), GO:0042127 (regulation of cell population proliferation), GO:0035556 (intracellular signal transduction), GO:0010646 (regulation of cell communication), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0006936 (muscle contraction), GO:0006915 (apoptotic process), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0043410 (positive regulation of MAPK cascade), GO:0006939 (smooth muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)