Protein: Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic (DHQ-SDH protein) (DHQase-SORase) (Protein EMBRYO DEFECTIVE 3004) [Includes: Dehydroquinate dehydratase (DHQ) (EC 4.2.1.10); Shikimate dehydrogenase (SDH) (EC 1.1.1.25)] (Q9SQT8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Bifunctional dehydroquinate dehydratase-shikimate dehydrogenase enzyme that catalyzes two steps in the chorismate biosynthesis pathway.
Subcellular location: Plastid, chloroplast {ECO:0000305}.
Sequence: MAASSTNARLTNPPRLLSKPRLSPTSVANLRFPAADFSTRFFADSSSPRLRSVPFPVVFSDQRRRRSMEPSNVYVASNSTEMEIGSHDIVKNPSLICAPVMADSIDKMVIETSKAHELGADLVEIRLDWLKDFNPLEDLKTIIKKSPLPTLFTYRPKWEGGQYEGDENERRDVLRLAMELGADYIDVELQVASEFIKSIDGKKPGKFKVIVSSHNYQNTPSVEDLDGLVARIQQTGADIVKIATTAVDIADVARMFHITSKAQVPTIGLVMGERGLMSRILCSKFGGYLTFGTLDSSKVSAPGQPTIKDLLDLYNFRRIGPDTKVYGIIGKPVSHSKSPIVHNQAFKSVDFNGVYVHLLVDNLVSFLQAYSSSDFAGFSCTIPHKEAALQCCDEVDPLAKSIGAVNTILRRKSDGKLLGYNTDCIGSISAIEDGLRSSGDPSSVPSSSSPLASKTVVVIGAGGAGKALAYGAKEKGAKVVIANRTYERALELAEAIGGKALSLTDLDNYHPEDGMVLANTTSMGMQPNVEETPISKDALKHYALVFDAVYTPRITRLLREAEESGAITVSGSEMFVRQAYEQFEIFTGLPAPKELYWQIMSKY
InterPro domains: - IPR022893: Shikimate dehydrogenase family (family) [92-602]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [449-601]
- IPR013708: Shikimate dehydrogenase substrate binding, N-terminal (domain) [328-408]
- IPR006151: Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase (domain) [450-533]
- IPR046346: Aminoacid dehydrogenase-like, N-terminal domain superfamily (homologous_superfamily) [315-422]
- IPR041121: SDH, C-terminal (domain) [571-595]
- IPR001381: 3-dehydroquinate dehydratase type I (family) [95-317]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [90-322]
- IPR011342: Shikimate dehydrogenase (family) [324-591]
Interaction partners: - 3-dehydroquinate synthase, chloroplastic
- Shikimate kinase 2, chloroplastic
- Shikimate kinase 1, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic
- 3-phosphoshikimate 1-carboxyvinyltransferase
- Chorismate synthase, chloroplastic
- Chorismate mutase 1, chloroplastic
- Chorismate mutase 2
- Chorismate mutase 3, chloroplastic
- Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901617 (organic hydroxy compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042537 (benzene-containing compound metabolic process), GO:0018958 (phenol-containing compound metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009712 (catechol-containing compound metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0046189 (phenol-containing compound biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0009713 (catechol-containing compound biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)