Protein: Thymic stromal lymphopoietin (Q9JIE6)
Organism: Mus musculus (Mouse)
Function: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity)
Subcellular location: Secreted
Sequence: MVLLRSLFILQVLVRMGLTYNFSNCNFTSITKIYCNIIFHDLTGDLKGAKFEQIEDCESKPACLLKIEYYTLNPIPGCPSLPDKTFARRTREALNDHCPGYPETERNDGTQEMAQEVQNICLNQTSQILRLWYSFMQSPE
InterPro domains: - IPR038329: Thymic stromal lymphopoietin superfamily (homologous_superfamily) [20-140]
- IPR029189: Thymic stromal lymphopoietin (family) [2-137]
Interaction partners: - Interleukin-7 receptor subunit alpha
- Cytokine receptor-like factor 2
- Interleukin-1 receptor-like 1
- Interleukin-33
- Interleukin-4
- Interleukin-4 receptor subunit alpha
- Interleukin-13 receptor subunit alpha-1
- Cytokine receptor common subunit gamma
- Interleukin-13
- Interleukin-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005125 (cytokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048522 (positive regulation of cellular process), GO:0002696 (positive regulation of leukocyte activation), GO:0042127 (regulation of cell population proliferation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:0001819 (positive regulation of cytokine production), GO:0001817 (regulation of cytokine production), GO:0050865 (regulation of cell activation), GO:0046649 (lymphocyte activation), GO:0050867 (positive regulation of cell activation), GO:0008284 (positive regulation of cell population proliferation), GO:0030097 (hemopoiesis), GO:0051251 (positive regulation of lymphocyte activation), GO:0002521 (leukocyte differentiation), GO:0042110 (T cell activation), GO:0010628 (positive regulation of gene expression), GO:0070665 (positive regulation of leukocyte proliferation), GO:0070663 (regulation of leukocyte proliferation), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0051249 (regulation of lymphocyte activation), GO:0032946 (positive regulation of mononuclear cell proliferation), GO:0050670 (regulation of lymphocyte proliferation), GO:0032944 (regulation of mononuclear cell proliferation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0046631 (alpha-beta T cell activation), GO:0050671 (positive regulation of lymphocyte proliferation), GO:0036037 (CD8-positive, alpha-beta T cell activation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)