Protein: Centractin (Actin-related protein A) (Q54I79)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Component of a multi-subunit complex, PPK2 (poly P kinase complex 2) involved in microtubule based vesicle motility. It is associated with the centrosome. PPK2 complex can synthesize a poly chain of hundreds of phosphate residues linked by ATP-like bonds.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15496465}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15496465}.
Sequence: MSSVEFSNQPVVIDNGSGVIKAGFAGQDPPSHIFQSLVGNPKYKKVMGLNIENESTYFVGDRINDWRGILKLKHPMDHGIVSNWSDMERVWTYTYDQLKIQPSEHPVLLTDVPNNPRLHRERAAQLFFETYNAPALYFSIPAVLSLYASGRTTGIVLDSGDGVTHVVPVFEGFALPHAISRIDIAGRDITEYLQHLLRRSGYNFKTSAEKEVVRIIKEKTCYVAHDPQKEEELLEPDSSSSKPVQPQYTLPDGNVIELGAERFRAPEILFHPDIIGDESLGIHQCLDMSIRKSDLDLRKTFYSNIILGGGSTLFQGFGDRLLNEVKKLAPKDIKIKITAPPERKYSAWMGGSILASLSTFKDLWVTRQEYEEDGCSVIHRKIF
InterPro domains: - IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [8-383]
- IPR004000: Actin family (family) [8-383]
- IPR004001: Actin, conserved site (conserved_site) [364-372]
Interaction partners: - Actin-related protein 10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005200 (structural constituent of cytoskeleton), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0017022 (myosin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0051234 (establishment of localization), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0009653 (anatomical structure morphogenesis), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0000902 (cell morphogenesis), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0009611 (response to wounding), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0006810 (transport), GO:0046683 (response to organophosphorus), GO:0051591 (response to cAMP), GO:0042060 (wound healing), GO:0016192 (vesicle-mediated transport), GO:0014070 (response to organic cyclic compound), GO:0010243 (response to organonitrogen compound), GO:0010256 (endomembrane system organization), GO:0061024 (membrane organization), GO:0001778 (plasma membrane repair), GO:0007009 (plasma membrane organization), GO:0014074 (response to purine-containing compound), GO:0006909 (phagocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0001891 (phagocytic cup), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031143 (pseudopodium), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0045335 (phagocytic vesicle), GO:0030864 (cortical actin cytoskeleton), GO:0097708 (intracellular vesicle), GO:0015629 (actin cytoskeleton)