Protein: E3 ubiquitin ligase rnf-121 (EC 2.3.2.27) (RING finger protein 121) (Q09251)
Organism: Caenorhabditis elegans
Function: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates such as the beta-integrin subunit pat-3, promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Negatively regulates the unfolded protein response to reduce endoplasmic reticulum stress. Required for the cessation of distal tip cell migration at the end of larval morphogenesis. Plays a role in germline and gonad development.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20357004}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20357004}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MGQHGAIRLQNEVQEGMPPPHELTEEEQWAEEHRKMHEKHKGHEAMHMEMMVIFMISVIVGQIFLVTWKRKHFKSYQMCTLIGMLTIPVYVCFNRSWYRFLATWLVFCIFSAFIWLKASAQHISGGTPRFVYKWFLFLHKLSYVLGVVGYLIMMGALLGFHVLFGVSQPTLMDAGILFMFYGVYYGVLGRDFAHICTARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLDDSEHVHDADAVVTTKMVEDEDEKLYKLSCGHVFHEFCIRGWVVVGKLQTCPYCKERVDLQRMFKNPWEKPHLFYGKLLDWIRYLVCWQPLIVTAVQGLTTWMGLE
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [222-284]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [217-290]
- IPR040176: RING finger protein RNF121/RNF175 (family) [17-335]
Interaction partners: - Nuclear speckle splicing regulatory protein 1 homolog
- E3 ubiquitin ligase rnf-5
- RING-type E3 ubiquitin transferase
- E3 ubiquitin-protein ligase hrd-like protein 1
- Zinc finger BED domain-containing protein 39
- Integrin beta pat-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0002020 (protease binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0050793 (regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0051649 (establishment of localization in cell), GO:0045595 (regulation of cell differentiation), GO:0046907 (intracellular transport), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0006810 (transport), GO:0016482 (cytosolic transport), GO:1901214 (regulation of neuron death), GO:0016192 (vesicle-mediated transport), GO:0016197 (endosomal transport), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0043524 (negative regulation of neuron apoptotic process), GO:0043523 (regulation of neuron apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)