wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (O94515)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MLSLLNPKAESIQRAQALQVNISAAIGLQDVLKSNLGPTGTTKMLVDGAGAIKLTKDGKVLLTEMQIQNPTASCIAKAATAQDDATGDGTTSVCLLVGELLKQAELYIREGLHPSLISDGFNLAKNEALTFLDSFKTDFEVDREVLLNVAKTSLSTKISSKVVESLAPAVVDAILTIRRPDEPIDLHMVEIMKMQNRSASDTQLIRGLLLDHGARHPDMPKQVKNAYILILNVSLEYEKSEINSGFFYSTSEQRERLVESERKFVDNKLRKIVELKKEVCERDPTANFVIINQKGIDPLSLDVLAKNGIMALRRAKRRNMERLQLACGGVAQNSVDDLNPEVLGWAGSVYERTLGEEKYTFVEDVKDPKSATILIHGPNTYTIQQIQDATRDGLRAVKNAVEDNCLIVGAGAFEVACAAHLRNKFAAKEVKGKAKMGVYAYADALLIIPKTLAANSSYDTQDAIVALQEEASEGYKVGLDLKTGMPFDPEVEGIYDNYRVIRHMLHSATVIASNLISVDQILRAGRSSLKEGPPQ
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [138-404]
- IPR053374: TCP-1 chaperonin-containing T-complex (family) [13-524]
- IPR012722: T-complex protein 1, zeta subunit (family) [2-530]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [201-377]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [28-525]
- IPR002194: Chaperonin TCP-1, conserved site (conserved_site) [33-90]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [11-523]
- IPR017998: Chaperone tailless complex polypeptide 1 (TCP-1) (family) [13-522]
Interaction partners: - T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit delta
- Probable T-complex protein 1 subunit beta
- T-complex protein 1 subunit alpha
- T-complex protein 1 subunit gamma
- Probable T-complex protein 1 subunit theta
- Probable T-complex protein 1 subunit eta
- Ribosome-associated molecular chaperone sks2
- Phosducin-like protein C2A9.09
- Probable prefoldin subunit 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0006457 (protein folding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:0005832 (chaperonin-containing T-complex), GO:0101031 (chaperone complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Alpha-lactalbumin (Lactose synthase B protein) (B6V3I5)
Organism: Bos taurus (Bovine)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MMSFVSLLLVGILFHATQAEQLTKCEVFRELKDLKGYGGVSLPEWVCTTFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIMCVKKILDKVGINYWLAHKALCSEKLDQWLCEKL
InterPro domains: - IPR023346: Lysozyme-like domain superfamily (homologous_superfamily) [21-141]
- IPR019799: Glycoside hydrolase family 22 domain (domain) [92-110]
- IPR001916: Glycoside hydrolase, family 22 (family) [2-142]
- IPR000545: Lactalbumin (family) [26-138]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0048545 (response to steroid hormone), GO:0097305 (response to alcohol), GO:0014070 (response to organic cyclic compound), GO:1901654 (response to ketone), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0031960 (response to corticosteroid), GO:0032570 (response to progesterone), GO:0051385 (response to mineralocorticoid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Probable G-protein coupled receptor egl-47 (Egg laying defective protein egl-47) (G5EDX4)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MYPFNRTTSIHAESASQHIDELDDDDFGRSNGKFYSNRHSQMDSDVVAHQVPPGSPVEKTILASILEMSTINDMWVKTFTAPGANKKDKKRRESLFECSWRGVHCVSNSLRSILFLFRLLAIFPATTDRKSRRKRNHRSIIKLILYVNYIVLAVLLNSFLIKMNFKVLMLYKHKFGLMHTGTVASMITATKPVINVFVIVLSAIKFKSHQRLLKTIDMVDVCFRSAFGVSPPLRIYKFVFFFTLLIIFFSALILKVVEFVGTGEIFGEHILTDCSFILVPVLSLWNIIPLLYYHLYNILVRFYCRTLIKSMNREHKKRHFSLKFYYEQFTRITNVQEAVGDVFNPLLLFSLAWSLLVLCLTLYFLSEPTSTLLVPITPEQVTNPKIREKLNITVHVKICWAAYQVVMAILHIIIICSTGMMTNETTRQIVNAVLRIVPDANADLDRFQISCFVHKMTTQFMWGMTVWRAFPLERTTFFTLISVIVTYSLLLFRFKDDMVQNPPYMAAMAVFNTSAVPTPAPG
InterPro domains: - IPR013604: 7TM chemosensory receptor (family) [110-495]
Interaction partners: - Inward rectifier potassium channel irk-1
- G protein-coupled receptor EGL-6 isoform b
- High-energy light unresponsive protein 1
- Gustatory receptor family protein 3
- G protein-coupled receptor
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0008527 (taste receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0007610 (behavior), GO:0042221 (response to chemical), GO:0007635 (chemosensory behavior), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0050909 (sensory perception of taste), GO:0050913 (sensory perception of bitter taste)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0043025 (neuronal cell body), GO:0120025 (plasma membrane bounded cell projection), GO:0097447 (dendritic tree), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0030425 (dendrite), GO:0030424 (axon), GO:0005634 (nucleus)
Protein: Copper transporter 1 (OsCOPT1) (Q94EE4)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Involved in the transport of copper, in cooperation with SWEET11 and COPT2. Contributes to the removal of copper (Cu) from xylem, and thus to the sensitivity toward bacterial pathogens such as X.oryzae pv. oryzae (Xoo).
Subcellular location: Cell membrane {ECO:0000269|PubMed:20852017}; Multi-pass membrane protein {ECO:0000269|PubMed:20852017}.
Sequence: MDMGGHDMGGMSPPAAGAAAQGGMGAMKSMRYTHMTFFWGKNSEVLFTMWPGTRGGMYALALIFVFALAVIVEFLGSRRADACLAALARRAPAAGGLARAAVHTVRVGVAYLLMLALMSFNGGVFLVAVAGHAAGFLAFRAGLCGGPAQVEEDRKNDPACC
InterPro domains: - IPR007274: Ctr copper transporter (family) [25-152]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005375 (copper ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0034220 (monoatomic ion transmembrane transport), GO:0098739 (import across plasma membrane), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0099587 (inorganic ion import across plasma membrane), GO:0006811 (monoatomic ion transport), GO:0098659 (inorganic cation import across plasma membrane), GO:0006812 (monoatomic cation transport), GO:0035434 (copper ion transmembrane transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006825 (copper ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0009705 (plant-type vacuole membrane)
Protein: 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Enamine/imine deaminase) (Q7CP78)
Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Function: Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities and to avoid they are captured by anthranilate phosphoribosyltransferase (TrpD) to generate PRA, an intermediate in the alternative pyrimidine biosynthetic (APB) pathway. Also required for full activity of IlvE which is involved in the isoleucine biosynthesis. RidA also accelerates the release of pyruvate produced by IlvA from L-serine.
Subcellular location: Cytoplasm {ECO:0000305}.
Sequence: MSKTIATENAPAAIGPYVQGVDLGSMVITSGQIPVDPKTGAVAEDVSAQARQSLENVKAIVEAAGLKVGDIVKTTVFVKDLNDFATVNATYEAFFTEHNATFPARSCVEVARLPKDVKIEIEAIAVRR
InterPro domains: - IPR006175: YjgF/YER057c/UK114 family (family) [3-126]
- IPR006056: RidA family (family) [3-126]
- IPR019897: RidA, conserved site (conserved_site) [103-121]
- IPR035959: RutC-like superfamily (homologous_superfamily) [1-127]
Interaction partners: - L-Threonine dehydratase biosynthetic IlvA
- L-threonine dehydratase catabolic TdcB
- Diaminopropionate ammonia-lyase
- Aspartate carbamoyltransferase regulatory chain
- Branched-chain-amino-acid aminotransferase
- Thiamine import ATP-binding protein ThiQ
- Aspartate carbamoyltransferase catalytic subunit
- Bifunctional protein TrpGD
- Arginine repressor
- Translation initiation inhibitor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0019239 (deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0019372 (lipoxygenase pathway), GO:0010597 (green leaf volatile biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006690 (icosanoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031469 (bacterial microcompartment)
Protein: Serine/threonine-protein phosphatase 2B catalytic subunit A1 (EC 3.1.3.16) (Calcineurin A1) (O42773)
Organism: Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin (By similarity).
Sequence: MASPATQTANAIAAINNRSNLVIPEIDFTQHQLENGEIVSTTERVIKDVQAPAMYVPTDDQFWSKVDKTKPDIAFLKNHFYREGRLTEEQALYILEKGGELLRSEPNLLEVDAPITVCGDIHGQYYDLMKLFEVGGNPADTRYLFLGDYVDRGYFSIECVLYLWSLKMWYPDTLFLLRGNHECRHLTDYFTFKLECKHKYSETVYNACMESFCNLPLAAVMNKQFLCIHGGLSPELHTLDDLRSINRFREPPTQGLMCDILWADPLEDFGSEKTNENFLHNHVRGCSYFFTYNAACQFLERNNLLSIIRAHEAQDAGYRMYRKTKTTGFPSVMTIFSAPNYLDVYSNKAAVLKYESNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILNCCTKEELEEEDEEFPLNAPEPTDAESAAERRQIIKNKILAVGRMSRVFSLLREESERVSELKSISGSNALPAGMLASGAEGIKEAIQGFEDARKSDIENERLPPDIIDPDEDKPASPSASPIMPATPEEIPSEIPYDSPITGTPRTPISSAIASGSPGSPGTPTSPSIGGPPLTAWRPGHGRRTSLGTTKTSPSTRRRSLENTMHLIRDVVGGKDAQGDGQLERLAEVISSPTKGGQGE
InterPro domains: - IPR006186: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (domain) [86-377]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [36-507]
- IPR041751: PP2B, metallophosphatase domain (domain) [71-375]
- IPR004843: Calcineurin-like, phosphoesterase domain (domain) [114-313]
- IPR043360: PP2B (family) [38-513]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity), GO:0004723 (calcium-dependent protein serine/threonine phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0051592 (response to calcium ion), GO:0071241 (cellular response to inorganic substance), GO:1901701 (cellular response to oxygen-containing compound), GO:1902075 (cellular response to salt), GO:0071277 (cellular response to calcium ion), GO:0071248 (cellular response to metal ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0140535 (intracellular protein-containing complex), GO:1903293 (phosphatase complex), GO:0008287 (protein serine/threonine phosphatase complex)
Protein: unspecific monooxygenase (EC 1.14.14.1) (Q5GLZ0)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004586}. Microsome membrane {ECO:0000256|ARBA:ARBA00004524}.
Sequence: MVLGVFLGLLLTCLLLLSLWKQNSQRRNLPPGPTPLPIIGNILQLDLKDISKSLRNFSKVYGPVFTLYLGKKPAVVLHGYKAVKEALIDHGEEFAGRGTFPVADKFIRRCGVVFSSGRTWKEMRRFSLMTLRNFGMGKRSIEDRVQEEARCLVDELRKTKGVPCDPTFILGCAPCNVICSIVFQNRFDYKDQEFLTFIDILNENVEILSSPWIQVCNNFPAIIDYLPGRHRKLLKNFDFAKHYFLAKVIQHKESLDINNPRDFIDCFLIKMEQEKHNPKTEFTCENLIFTASDLFAAGTETTSTTLRYSLLLLLKYPEVTAKVQAEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRYIDLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFLNPERFDPSHFLDESGKFKKSDYFFPFSTGKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFVSVPPKFQICFISI
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [19-490]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [428-437]
- IPR001128: Cytochrome P450 (family) [30-487]
- IPR002401: Cytochrome P450, E-class, group I (family) [58-458]
- IPR050182: Cytochrome P450 family 2 (family) [9-485]
Interaction partners: - Cytochrome P450 1A2
- Cytochrome P450 2U1
- Cytochrome P450 2E1
- Epoxide hydrolase 1
- Arachidonate 12-lipoxygenase, 12R-type
- Polyunsaturated fatty acid lipoxygenase ALOX15
- Polyunsaturated fatty acid lipoxygenase ALOX8
- Polyunsaturated fatty acid 5-lipoxygenase
- Cytochrome P450 7A1
- Cytochrome P450 4A12B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0008391 (arachidonic acid monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0120254 (olefinic compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0019369 (arachidonic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0033559 (unsaturated fatty acid metabolic process), GO:0001676 (long-chain fatty acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006690 (icosanoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 3-succinoylsemialdehyde-pyridine dehydrogenase (SAPD) (EC 1.2.1.83) (H8ZPX2)
Organism: Pseudomonas sp
Function: Catalyzes the dehydrogenation of 3-succinoylsemialdehyde-pyridine to 3-succinoyl-pyridine in the nicotine degradation pathway.
Sequence: MRDYREFYIDGQWVRPKGAREAEVINPATEKIVGLISLGTEEHVDLAVRAARRAFDGWSRTSKDQRLELLEQVCRAFESKLDEIAKAITEEMGAPLVQLALPLQAPAGLGHFLTAASILRDYDFEESLGTTRVVREPAGVCGLITPWNWPLNQIAAKVAPALAAGCTMVLKPSEIAPFSAYLLARIFDEVGVPPGVFNLVNGDGPGVGAPLAAHPEVDLVSFTGSTRAGTLVSTAAAPTVKRVALELGGKSANIILDDADLETAVKHGVRTMMLNTGQSCNAPSRMLVPLSKLDEVEHLAEHFCKEIVVGDPMHSDTNIGPLASGMQYEKVQDCIRQGVAEGAKLICGGLGRPDGLESGYFAQPTIFSAVNKQMYIAREEIFGPVLCIMPYGDENEAIQIANDSCYGLSGYVSSGSLERARNVAKQLRTGAVHLNGAALDFTAPFGGYKQSGNGREWGKYGFEEFLEIKAVMGYEGS
InterPro domains: - IPR015590: Aldehyde dehydrogenase domain (domain) [13-471]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [5-472]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [24-466]
- IPR029510: Aldehyde dehydrogenase, glutamic acid active site (conserved_site) [245-252]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [249-440]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor), GO:0004030 (aldehyde dehydrogenase [NAD(P)+] activity), GO:0004029 (aldehyde dehydrogenase (NAD+) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0120252 (hydrocarbon metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006805 (xenobiotic metabolic process), GO:1901575 (organic substance catabolic process), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0044248 (cellular catabolic process), GO:0071466 (cellular response to xenobiotic stimulus), GO:0042178 (xenobiotic catabolic process), GO:0019439 (aromatic compound catabolic process), GO:0120253 (hydrocarbon catabolic process), GO:1901361 (organic cyclic compound catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Large ribosomal subunit protein mL51 (39S ribosomal protein L51, mitochondrial) (A0A0B4J2C1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Sequence: MFGVYDNIGILGNFEKHPKELIRGPIWLRGWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR
InterPro domains: - IPR019373: Large ribosomal subunit protein mL51 (family) [1-75]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0010467 (gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)