Protein: SH3 and PX domain-containing protein 2B isoform X3 (A0A0R4IRP5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell projection, podosome. Cytoplasm
Sequence: MPRRTVLEVTVQDVQKRRNPNKHYVYIIKVAWSDGSTEVIFRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKILFRRSHIRDVAMKRLKPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPSGKKKSGGDSSSADPLLLDQYVAVTDYEKQESSEISLYVGQVVEVIEKNESGWWFVSTEDAQGWVPATCLEAQDDPDDFSLPAEEEEKYTAIYPYSARDQDEIDLERGMTVEVIQKNLEGWWKIRYQGKEGWAPASYLKKADILSQKMAAGAPVHASTNDLDVACKQQNANKENKENQRDRFSPFSDSKRKVGARQRPPPRRDLTIPRGVNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGLKVEVIEKNSSGWWYIQIEDKEGWAPVTFIDKYKKTSSASRPNFLAPLPGEMEQLKLEDTSSNSTNSEHTWSKPLPDEPSSNSDLSTRSKLREWKPNAAKSSSHFSGPLPPPPSSPTAEEKPALPPRRESINKSLELEDKPKAELSKPLPPKPPVPGVIAPLVTPKAAPLKPDKPPEMKKDDKNKQLFLRNEMGLECGHNISVKEVKKFNLKHVAKQPPTKPKPDLQEDKPESPNPAPFLKPKPVIRPKPAPAAKPEPVAKNELDITNLRSKLRPSKPPELNSSDANQQNDTSSSSPPNNSRTNEEPKCLPKQQNGHGPSETTKPPKEPPQRPSVAPRRPPPPKKSSEPASPTDTRAPQKDLPEAKPAPPPQSRPPPPKTKAFPLPAPKDKEKEEPKPKVPVPPKPLVKPDKPGPPRDKLPPLIKEPSKEELFLAVADFEGDEQTPGFKEGAVFEVMERNTSGWWFCKNVSDGPVMEGWIPSNYLTKKP
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [151-866]
- IPR051228: NADPH Oxidase and PX Domain-Containing (family) [2-639]
- IPR036871: PX domain superfamily (homologous_superfamily) [2-137]
- IPR001452: SH3 domain (domain) [151-868]
- IPR035479: SH3PXD2B, SH3 domain 3 (domain) [359-411]
- IPR001683: Phox homology (domain) [4-128]
- IPR035480: SH3PXD2B, SH3 domain 4 (domain) [811-866]
- IPR037961: SH3PXD2, PX domain (domain) [6-124]
- IPR035477: SH3PXD2B, SH3 domain 1 (domain) [154-208]
- IPR035478: SH3PXD2B, SH3 domain 2 (domain) [222-275]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0043168 (anion binding), GO:0019904 (protein domain specific binding), GO:0035091 (phosphatidylinositol binding), GO:0042169 (SH2 domain binding), GO:0080025 (phosphatidylinositol-3,5-bisphosphate binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:0032266 (phosphatidylinositol-3-phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding), GO:0010314 (phosphatidylinositol-5-phosphate binding), GO:0070273 (phosphatidylinositol-4-phosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0016477 (cell migration), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0001667 (ameboidal-type cell migration), GO:0014033 (neural crest cell differentiation), GO:0014032 (neural crest cell development), GO:0090497 (mesenchymal cell migration), GO:0001755 (neural crest cell migration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0002102 (podosome), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)