Protein: Topoisomerase 1-associated factor 1 (Q59NW5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity)
Subcellular location: Nucleus
Sequence: MSDYESGSDIDNYYEADEFDDFIEYSDNEVEQEKSKPTPGQIEVEEIEEPEEDRIRTLTTTLKPNETQAQKLLKAHISVLVSALGGPDHTSDIQPPPYKLGHDALACLKDIKRWIRAVDEKKNNYEVALACAESGLVTNDLIVIMCQWEDKMQKKEIIKNKTTTEKTMLACLELLVLLTWPVEFGKDLSESQKLLYSEIKKVHVSYKKQILMFNNGQLLKAAIRLVLPTIAKSRIDREPRDNQILKLVLYLIRNLLAIEPANLSISNKSRKGASVTASDLPLGVTQDDISINNVLSVFKKNKVLMLLLTISGSLGTEFDRDMFGEICLESIYLIIKGLSASEVLVKKNLGSTPVAAPSQNTVPDAINASQPLQPVTTTVGMQLQDLLATESKKKKIQTQNIASRHGRFGSLLSIRSADSNSFVVSGQEALINTDSSLAKLDKSKKWKDRTYFKYDSDEYVNTSTPVYLNLTGQDILYNFVEQFLSGGCFNNLIECMGSRLTSQTDLNMVDELTLASYFFTISWFLSYQRERIGLDSENKELNYGSVGAALSEVNFILIIGYFRDSFSVKKWNSLHVAMICFKELLQISNSVFGKEITNQTGEGDEISQHEIDRELAEGIIRKLFSFNDFLSIIVQIPQTAAKHSPDYLRVSVSVVHILLKAFETFANEDVHLYIQSKRKQSKRNRKRVNNLDKSTEDRLRDVIYASDEELDQSSAKEITQERKLDFKKTEARFFHQAIVSTYINYLSRYEDLSNQEIKTCLSYFHRLFVVRKDFTGLYRLDFMQLLQKLRNYLQRGSSLRLQVEEFIYYFMKKFKTAFERFPMPIEVLFPRFEDNECKVYLATGEVYEKEETTSTSRSPRLAKDLEFVRDFGLDDQIKILVSQLHVQEKQSLLKWLIQELERIINDRILNSDSIAELNASNQQRRLFINNGYLRFLLRIIGFDLPYTMEEVPELATTVDMEHLTKVTELIKKWDSSQPVIFEDDKVPSYFVRTREAGYDEDQYNENDQEYDFNDDSIAFETEANPNSNRNHVSELDHLEELERQLSSNGSRVNSKERNGTKGKARKKSKEKKRPEPKKVRGLKRRRIPKDLLDDDDSQHVVKSAEFVHDSDDESDDEKDKAFFEREEKMRNLLNDMGGIATSEQLKEIQKVWKNLETGGNNKVASTVAKAVKEVGLFVEESDNDDEVEEESRNSAPVNEEADRTIFESGEVDTQQDLSDNTSNTSDMESETETTKRSFVEDPEEISHVQPKRKRLVISDDEEE
InterPro domains: - IPR006906: Timeless, N-terminal (domain) [97-414]
- IPR044998: Timeless (family) [75-1263]
Interaction partners: - Chromosome segregation in meiosis protein 3
- DNA replication licensing factor MCM2
- DNA replication initiation factor
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM4
- Replication protein A subunit
- Chromatin-binding protein
- DNA replication licensing factor MCM6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0030447 (filamentous growth), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:1990234 (transferase complex), GO:0035097 (histone methyltransferase complex), GO:0043229 (intracellular organelle), GO:0034708 (methyltransferase complex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)