Protein: Thymidylate synthase (P12461)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Sequence: MTVSPNTAEQAYLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKVFSKGIIHELLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQWRHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWNPPDFAKMALPPCHVFCQFYVNFPTSSPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPFNIASYALLTKMIAHVVDMDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEERKNEIKSIDDFKFEDFEIVGYEPYPPIKMKMSV
InterPro domains: - IPR045097: Thymidylate synthase/dCMP hydroxymethylase (family) [4-315]
- IPR023451: Thymidylate synthase/dCMP hydroxymethylase domain (domain) [10-315]
- IPR000398: Thymidylate synthase (family) [9-315]
- IPR036926: Thymidylate synthase/dCMP hydroxymethylase superfamily (homologous_superfamily) [1-315]
- IPR020940: Thymidylate synthase, active site (active_site) [156-184]
Interaction partners: - Dihydrofolate reductase
- Thymidylate kinase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Deoxyuridine 5'-triphosphate nucleotidohydrolase
- Deoxycytidylate deaminase
- Methylenetetrahydrofolate dehydrogenase [NAD(+)]
- Serine hydroxymethyltransferase
- Serine hydroxymethyltransferase, cytosolic
- Mis12p
- C-1-tetrahydrofolate synthase, cytoplasmic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0019692 (deoxyribose phosphate metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0009262 (deoxyribonucleotide metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0072527 (pyrimidine-containing compound metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009123 (nucleoside monophosphate metabolic process), GO:0072528 (pyrimidine-containing compound biosynthetic process), GO:0006220 (pyrimidine nucleotide metabolic process), GO:0009263 (deoxyribonucleotide biosynthetic process), GO:0009117 (nucleotide metabolic process), GO:0009394 (2'-deoxyribonucleotide metabolic process), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0046385 (deoxyribose phosphate biosynthetic process), GO:0009162 (deoxyribonucleoside monophosphate metabolic process), GO:0009129 (pyrimidine nucleoside monophosphate metabolic process), GO:0009265 (2'-deoxyribonucleotide biosynthetic process), GO:0009124 (nucleoside monophosphate biosynthetic process), GO:0009219 (pyrimidine deoxyribonucleotide metabolic process), GO:0009165 (nucleotide biosynthetic process), GO:0006221 (pyrimidine nucleotide biosynthetic process), GO:0009221 (pyrimidine deoxyribonucleotide biosynthetic process), GO:0009130 (pyrimidine nucleoside monophosphate biosynthetic process), GO:0009176 (pyrimidine deoxyribonucleoside monophosphate metabolic process), GO:0009157 (deoxyribonucleoside monophosphate biosynthetic process), GO:0009177 (pyrimidine deoxyribonucleoside monophosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)