Protein: Metalloendopeptidase (EC 3.4.24.-) (F1REM3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MELAARCALLLSSFSLLAALDLDAIEPGYYVETSSPSDLIDYKDPCKAVAYLGDIALDEEDMRMFTVDRIVNLADRTVTILNHTNTGSLSNETSVNTTASSRGSHRRRRAATSRPERVWPEGVIPYVISGNFSGSQRAIFRQAMRHWEKHTCVTFIERTTEESYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDEHVSIIRDNIQPGQEYNFLKMEPGEVDSLGEVYDFDSIMHYARNTFSRGIFLDTILPRYDVNGVRPPIGQRTRLSKGDIAQARKLYKCPRCGDSLQESSGNFSSPGYPNGYSAYMHCIWRISVTPGEKIILNFTSMDLYRSHLCWYDHVEIRDGYWRKAPLKGRFCGDKLPDPIISTDSRLWIEFRSSSNWVGKGFSAVYEAICGGEVKKDNGQIQSPNYPDDYRPNKVCVWKITVAQGYHVGLTFQSFEIERHDNCAYDYLEVRDGNSESSPLLGRFCGYDKPDDIKSSSNQLWMKFVSDGSVNKAGFAANFFKEMDECSRPDNGRCEQRCVNTLGSYKCACDPGYELAADKRSCEAACGGFITKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRITLLFDVFETEGNDVCKYDFVEVRSGLSADSRLHGKFCGAEKPEAITSQYNNMRIEFKSDNTVSKKGFKAQFFSDKDECSKENGGCQHECVNTFGSYSCQCRSGFVLHENKHDCKEAGCDHVVNSVSGTITSPNWPDKYPSKKACTWALSTTPGHRIKIAFNEIDMEPHLECAYDHIEIYDGRDSKAQSLGRYCGTKKPQPIISTGNKMFIRFFSDNSVQKKGFEASHTAECGGRLKAEVKTKDLYSHAQFGDNNYPGASDCQWVITAEKGYGVELIFQTFEIEEEADCGYDYMELFDGADTKSPRLGRYCGSGPPEEIYSAGDSIVIKFHSDDTINKKGFHVRYTSTKFQDTLHSRKK
InterPro domains: - IPR034036: Tolloid/BMP1 peptidase domain (domain) [112-309]
- IPR001881: EGF-like calcium-binding domain (domain) [536-732]
- IPR006026: Peptidase, metallopeptidase (domain) [115-257]
- IPR018097: EGF-like calcium-binding, conserved site (conserved_site) [536-716]
- IPR001506: Peptidase M12A (domain) [110-309]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [110-305]
- IPR000152: EGF-type aspartate/asparagine hydroxylation site (ptm) [552-718]
- IPR015446: Bone morphogenetic protein 1/tolloid-like protein (family) [2-976]
- IPR000859: CUB domain (domain) [311-965]
- IPR035914: Spermadhesin, CUB domain superfamily (homologous_superfamily) [306-973]
- IPR000742: EGF-like domain (domain) [536-732]
- IPR049883: NOTCH1 EGF-like calcium-binding domain (domain) [692-731]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0001503 (ossification), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0071704 (organic substance metabolic process), GO:0032963 (collagen metabolic process), GO:0007389 (pattern specification process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009799 (specification of symmetry), GO:0048736 (appendage development), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0003002 (regionalization), GO:0043170 (macromolecule metabolic process), GO:0048731 (system development), GO:0009855 (determination of bilateral symmetry), GO:0033333 (fin development), GO:0009953 (dorsal/ventral pattern formation), GO:0006508 (proteolysis), GO:0001501 (skeletal system development), GO:0048264 (determination of ventral identity), GO:0048262 (determination of dorsal/ventral asymmetry)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)