Protein: E3 ubiquitin-protein ligase SIAH1B (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1B) (Seven in absentia homolog 1b) (Siah-1b) (Siah1b) (Q06985)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes.
Subcellular location: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
Sequence: MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAVEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
InterPro domains: - IPR013010: Zinc finger, SIAH-type (domain) [93-153]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [24-148]
- IPR004162: E3 ubiquitin-protein ligase SINA-like, animal (family) [13-281]
- IPR008974: TRAF-like (homologous_superfamily) [149-282]
- IPR049548: E3 ubiquitin-protein ligase Sina-like, RING finger (domain) [41-75]
- IPR018121: Seven-in-absentia protein, TRAF-like domain (domain) [182-278]
- IPR001841: Zinc finger, RING-type (domain) [41-76]
Interaction partners: - Calcyclin-binding protein
- Catenin beta-1
- Axin-1
- E3 ubiquitin-protein ligase SIAH1A
- Adenomatous polyposis coli protein
- Ubiquitin carboxyl-terminal hydrolase 19
- Glycogen synthase kinase-3 beta
- Dapper homolog 1
- Beta-catenin-interacting protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0046983 (protein dimerization activity), GO:0019787 (ubiquitin-like protein transferase activity), GO:0042802 (identical protein binding), GO:0043169 (cation binding), GO:0019904 (protein domain specific binding), GO:0046872 (metal ion binding), GO:0004842 (ubiquitin-protein transferase activity), GO:0042803 (protein homodimerization activity), GO:0097718 (disordered domain specific binding), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0009056 (catabolic process), GO:0009791 (post-embryonic development), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:1903046 (meiotic cell cycle process), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0048638 (regulation of developmental growth), GO:1901564 (organonitrogen compound metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0044248 (cellular catabolic process), GO:0019538 (protein metabolic process), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0043170 (macromolecule metabolic process), GO:0007283 (spermatogenesis), GO:0140013 (meiotic nuclear division), GO:0040014 (regulation of multicellular organism growth), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0007140 (male meiotic nuclear division), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0007141 (male meiosis I), GO:0016055 (Wnt signaling pathway), GO:0030163 (protein catabolic process), GO:0007127 (meiosis I), GO:0009057 (macromolecule catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0048285 (organelle fission), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0060070 (canonical Wnt signaling pathway), GO:0010498 (proteasomal protein catabolic process), GO:0000280 (nuclear division), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex), GO:1990234 (transferase complex), GO:0000151 (ubiquitin ligase complex), GO:0031461 (cullin-RING ubiquitin ligase complex), GO:0019005 (SCF ubiquitin ligase complex)