Protein: Rho-associated protein kinase (A0A8M1NDD8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Nucleus
Sequence: MSTGAGKRIESRVRKLETLIKNQKSPLNLESLLDSVTALALDLNHPALRKNKNIDAFLSRYEKAVCNLKELQVKLDDFDRVKLIGRGAFGAVQLVRHKVSQQVYAMKQLSKFEMVKRSDSAFFWEERDIMAFSQSPWIVQLCCAFQDEKYLYLVMEFMPGGDLVTLTSNYDIPEEWAQFYTAEVVLALDAIHSLGFIHRDIKPDNMLLDRNGHLKLADFGTCMKMDSTGMVRCDTAVGTPDYISPEVLMSQGGTGYYGRECDWWSVGVFIYELLVGDTPFYSESLVGTYGKIMDHKNSLTFPDDIEMSKNAKDLICAFLSSREVRLGRTGVDEIKCHPFFKNDQWTFDTIRDTMAPVVPELSSDIDTSNFDDDIKDDPIGTETFPPPRAFAGNQLPFVGFTYFREDQLLTQQNKCSEEDIIEDHGLNHTESNDLEKRLKKLEEKFKHEMQAKEELENKCRIANQRLEKLSKDLEEEVNARQEAEDNLRSLEKEKVLLKHQRTQSVRKAGLETDRKRLLENEVSSLKEQLAELKKKNQISHLSAEKNIHLERQLEEVSAKLQAELEESERLKKAQIEAFRQSQQLELSLRELQERLAQLENSRLVLEQDKLSLQTSLELEKRERNAGSETITDLQGRIYGLEGELKHIKSSLSKAEVEKRQLQEDLTTLEKEKNKQEIDLSFKLKAVQQSLEQEEAEHKTTKARLADNNKINQSIEAKSETLKDMEHKLLEERSAKQQLENRLMQLEKENSVLDCDYKQAKHELQELRSLKENLTEQVEVLNVRVQQETQRKTLCQGDLKVQRQEINSLRSSEQQLKQELNHLLELKLTLEKQNQELSKEREESEKQLKEMKDQLEAEQYFTKLYKTQIRELKEESDEKVKLYKDAQQRIEDLQEERDSLASQLEVSLTKADSEQLARITVEEQYSDLEKEKIMKELEIKDMIARHRQDLAEKDGTINSLEESNRTLTVDVANLASEKEELNNKLKHIQQKLEKIKEEEKQMKSLTVSYEKQIQVEKTLKIQAINKLAEVMKKTDGRPHQINNTDIRRKEKEIRQLQLQLRTEKEKLNHSIIKYQREINDMQAMIAEESQVRLEMQMSLDSKDSDIERLRSQLTSLSIHSLDTTSISSIGNDLDSDEAYPAAESGLEGWLSMPAKNTKRFGWDKKYVVVSSKKILFYDSEQDREQSSPFMILDIDKLFHVRPVTQTDVYRADPREIPRIFQILYANEGESKKEELPVESLSVTERSLCIPHKGHEFVLTLYHFPSSCEVCPRPLWHVFRPPPALECRRCRVKCHKDHIDRKEEVLAPCRVNYDMSTAKEMLLLANSTEEQKKWVSRLLKRVPRKPSIAHSSSIAISAAPSEATPTTLSPQPSPRLAQSSPRLSHRAAVKVHSTRQQPSSKNR
InterPro domains: - IPR008271: Serine/threonine-protein kinase, active site (active_site) [196-208]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [1144-1243]
- IPR001849: Pleckstrin homology domain (domain) [1142-1343]
- IPR020684: Rho-associated protein kinase 1/2 (family) [2-1390]
- IPR050839: Rho-associated Serine/Threonine Kinase (family) [9-580]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [75-398]
- IPR015008: ROCK, Rho binding domain (domain) [966-1035]
- IPR057529: MRCK/ROCK kinase, PH domain (domain) [1145-1227]
- IPR017441: Protein kinase, ATP binding site (binding_site) [84-107]
- IPR000961: AGC-kinase, C-terminal (domain) [341-412]
- IPR000719: Protein kinase domain (domain) [78-340]
- IPR017892: Protein kinase, C-terminal (domain) [361-402]
- IPR002219: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain (domain) [1252-1307]
- IPR046349: C1-like domain superfamily (homologous_superfamily) [1250-1310]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009056 (catabolic process), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048729 (tissue morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0032970 (regulation of actin filament-based process), GO:0043170 (macromolecule metabolic process), GO:0001704 (formation of primary germ layer), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0016477 (cell migration), GO:0048333 (mesodermal cell differentiation), GO:1901565 (organonitrogen compound catabolic process), GO:0016055 (Wnt signaling pathway), GO:0001707 (mesoderm formation), GO:0030163 (protein catabolic process), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0032956 (regulation of actin cytoskeleton organization), GO:0002009 (morphogenesis of an epithelium), GO:0001667 (ameboidal-type cell migration), GO:0009057 (macromolecule catabolic process), GO:0003007 (heart morphogenesis), GO:0072359 (circulatory system development), GO:0048332 (mesoderm morphogenesis), GO:0033043 (regulation of organelle organization), GO:0007498 (mesoderm development), GO:0060429 (epithelium development), GO:2000027 (regulation of animal organ morphogenesis), GO:0007507 (heart development), GO:0035567 (non-canonical Wnt signaling pathway), GO:0051493 (regulation of cytoskeleton organization), GO:0042074 (cell migration involved in gastrulation), GO:0090175 (regulation of establishment of planar polarity), GO:0060026 (convergent extension), GO:0007039 (protein catabolic process in the vacuole), GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)