wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Golgi-associated RAB2 interactor protein 4 (Golgi-associated Rab2B interactor-like 4) (GARI-L4) (GARI-like 4) (Q8IYT1)
Organism: Homo sapiens (Human)
Function: RAB2B effector protein required for the compacted Golgi morphology, probably through interaction with small GTPase RAB2B.
Subcellular location: Golgi apparatus {ECO:0000269|PubMed:26209634}.
Sequence: MNADFLLPYYTAQSGSSMSMFNTTMGKLQRQLYKGEYDIFKYAPIFESDFIQITKRGEVIDVHNRVRMVTMGIARTSPILPLPDVMLLARPATGCEEYAGHGQATKRKKRKAAKNLELTRLLPLRFVRISVQDHEKQQLRLKFATGRSCYLQLCPALDTRDDLFAYWEKLIYLLRPPMESNSSTCGIPAEDMMWMPVFQEDRRSLGAVNLQGKGDQDQVSIQSLHMVSEVCGATSAAYAGGEGLQNDFNKPTNVLNASIPKTSTELAEEPATGGIKEAAAAGAAAGAATGTVAGALSVAAANSAPGQVSAAIAGAATIGAGGNKGNMALAGTASMAPNSTKVAVAGAAGKSSEHVSSASMSLSREGSVSLAIAGVVLTSRTAAEADMDAAAGPPVSTRQSKSSLSGQHGRERTQASAEGCKEGRERREKDRALGRSSHRRRTGESRHKTRGDKIAQKSSSRSSFSHRANRDDKKEKGCGNPGSSRHRDSHKGVSHTPISKESRTSHKSGRSLWTTSSGSSKGLGRVSSFLRNVRANLTTKVVGTPHGRDVNVMAKMAERSTNVAIAETAEGGQGLETVGSMTPDIMETVTFEAH
InterPro domains: - IPR022168: Golgi associated RAB2 interactor protein-like, Rab2B-binding domain (domain) [115-183]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0019222 (regulation of metabolic process), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0043207 (response to external biotic stimulus), GO:0001817 (regulation of cytokine production), GO:0009615 (response to virus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0010628 (positive regulation of gene expression), GO:0140546 (defense response to symbiont), GO:0032481 (positive regulation of type I interferon production), GO:0051607 (defense response to virus), GO:0010468 (regulation of gene expression), GO:0032479 (regulation of type I interferon production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Miple2 (Q9U3W4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MNLILALTTALHLVLVVLAHNPLSTRGESLSDGIRLVMEKRSGDVVHIRPARGTLEAETVASTTNSDTHRTRNNRKPNKPQEHSQQVGAHKSGSRKLVVAENGGALSSQLPQPNHKQGHKNTDKQQRGGGSKQQRGHSQHHGGNRKGPKAATPENGSTCRYAKSAWSNCDHKTNMRSRVLSLRKGEQNCLPTRTIQKKCKKGCRYEKGEWSQCVGGQITREDKLEPEATGGSDQNCNPVRTVSKKCKANGNSSGGKQHGQSRRTKEQKQKDKGASRISS
InterPro domains: - IPR020090: Pleiotrophin/Midkine, C-terminal domain (domain) [157-255]
- IPR038130: Pleiotrophin/Midkine, C-terminal domain superfamily (homologous_superfamily) [159-246]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0097367 (carbohydrate derivative binding), GO:0008201 (heparin binding), GO:0005539 (glycosaminoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0008340 (determination of adult lifespan)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: MFS siderochrome iron transporter D (EC 7.-.-.-) (Q4WF51)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Major facilitator transporter involved in fusarinine C (FsC) uptake. In contrast to TAFC-mediated iron uptake, FsC-mediated iron uptake via mirD does not play a significant role during infection.
Subcellular location: Cell membrane {ECO:0000305|PubMed:36125294}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MLSSWQKKFFQTPEHPPAEGIAPPRDDGVPNPEPVTYPDTKYPSDVVNHDAGEMLPNEEAQDGVTQAEAITLTWSKISLGAAYFLMWLLYLVNGFQASITGNLSAYVTSGFESHSLIPVISIVSSVMSAATYMPLAKVLNLWDRSIGFIIMVAFATLGLILSATCHDIGTYCAAQVFYSIGFAGIIFSVDVITADTSTLRDRGLAYAFTSSPYIITAFGGPAAAEHFYDSNWRWAYGCFSIVLPVVALPMFCLLRWNRHKAKKSGLLKDKADSGRTWMESIRHYIIEFDILGVFFLAAGLVLFLLPFSIAGSTEDDWKSASIITMLVIGFVCLLVFALVERFVAPVPFLPWALLASRTVLGACMLDVCYQIAYYCWFNYYTSYLQVVYGTSITTAGYITSIFDVVSGVWLFIVGFLIKKTNRFRWLLFIAVPLYILGVGLMIYFRKPSWSVGYMIMCQIFIAFAGGTMIICQQVAVLAASDHDHAASSLAFLNVFGTMGSAVGSSISGAIWTHTLPGALQRLLPDSVKADWQTIYDSLEEQLSYERGTLIRQAIALAYASTQSKMLIAGTAIMALSLVWMFVIRDIKLTKTQTKGVLF
InterPro domains: - IPR011701: Major facilitator superfamily (family) [86-503]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [68-588]
- IPR020846: Major facilitator superfamily domain (domain) [82-586]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015343 (siderophore-iron transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0051234 (establishment of localization), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0006810 (transport), GO:0051649 (establishment of localization in cell), GO:0098771 (inorganic ion homeostasis), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:0055080 (monoatomic cation homeostasis), GO:0033212 (iron import into cell), GO:0071702 (organic substance transport), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0055072 (iron ion homeostasis), GO:0042886 (amide transport), GO:0006812 (monoatomic cation transport), GO:0015833 (peptide transport), GO:0033214 (siderophore-dependent iron import into cell), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006826 (iron ion transport), GO:1901678 (iron coordination entity transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Coiled-coil domain-containing protein 8 (Q9H0W5)
Organism: Homo sapiens (Human)
Function: Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:24793695}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24793695}.
Sequence: MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIMEKSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQGPRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMFEDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAPEGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAADSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQREEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAPAVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRFQTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL
InterPro domains: - IPR026526: Coiled-coil domain-containing protein 8 (family) [470-517]
Interaction partners: - Obscurin-like protein 1
- Cullin-7
- Ankyrin repeat family A protein 2
- Cellular tumor antigen p53
- Cullin-9
- F-box/WD repeat-containing protein 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0010506 (regulation of autophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Tegument protein US22 (F5HDC7)
Organism: Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Function: Not known
Subcellular location: Virion tegument {ECO:0000250}.
Sequence: MSLLTKAAAEAWGTYLRQRDERCEDAIRCDYGVFQFRNTVFQKTLSMLQGLYLRQYDPPALRTYVQRHQGTTVALRNPANWFLVMREQAAIPQIYARSLAADYLCCDDTLEAVGVLAVRPPDSDLTRNTKQAQELPCVLMLSHYGTVYVYDWETDGLYEVASDIKAFSKNGLLWCEYVYRHPQTPFATTEPRYHVQKFLCTDPTDAAAVAKTAREMNGLNLVIRTPGRTEVEPLLMLGSIEGLRACRPFDHMPAADFRDLLNFIRQRLCCEWYVVGLVGYYLAYGPFVPSGMVLLDKFGVVYLHKIEDSDLYRIADNFHMFLKCGLLKLRGLCRFDRGLRGECRLEELPVCHHTLKRDVLRWHGALGTITRSQLESALDWFLRPTRGTDKVPNNSSAWGRTDLLPTGALQDNQNWAFPSHSVETLPALQGGLWEDNDETTQTVDGQRCFRMPKFFPPPMCRAPYNECGVELPGGDSSDEDESGRPRRIANRIGDTPETPCNSENEDDTTVEGTSGGPEAMDSQAPYPSEDSPTTEKEAWLQRGRRAKAMHARGHTLKQVPIPEPDQMGDDGPDPGP
InterPro domains: - IPR003360: US22-like (family) [55-330]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0039693 (viral DNA genome replication), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0039686 (bidirectional double-stranded viral DNA replication), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0044423 (virion component), GO:0019033 (viral tegument)
Protein: Activator of photopigment and puc expression (P74295)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Not known
Sequence: MSLYRLIYSSQGIPNLQPQDLKDILESSQRNNPANGITGLLCYSKPAFLQVLEGECEQVNETYHRIVQDERHHSPQIIECMPIRRRNFEVWSMQAITVNDLSTEQVKTLVLKYSGFTTLRPSAMDPEQCLNFLLDIAKIYELSDNFFLDL
InterPro domains: - IPR007024: BLUF domain (domain) [3-95]
- IPR036046: Acylphosphatase-like domain superfamily (homologous_superfamily) [2-141]
Interaction partners: - PatA subfamily
- Riboflavin synthase
- Phytochrome-like protein cph2
- Circadian input-output histidine kinase CikA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0009521 (photosystem), GO:0030096 (plasma membrane-derived thylakoid photosystem II), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0009523 (photosystem II), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009579 (thylakoid), GO:0030075 (bacterial thylakoid)
Protein: Cilia- and flagella-associated protein 300 (Q9BRQ4)
Organism: Homo sapiens (Human)
Function: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:A0CY51}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A0CY51}.
Sequence: MATGELGDLGGYYFRFLPQKTFQSLSSKEITSRLRQWSMLGRIKAQAFGFDQTFQSYRKDDFVMAFFKDPNVIPNLKLLSDSSGQWIILGTEVKKIEAINVPCTQLSMSFFHRLYDEDIVRDSGHIVKCLDSFCDPFLISDELRRVLLVEDSEKYEIFSQPDREEFLFCLFKHLCLGGALCQYEDVISPYLETTKLIYKDLVSVRKNPQTKKIQITSSVFKVSAYDSAGMCYPSAKNHEQTFSYFIVDPIRRHLHVLYHCYGVGDMS
InterPro domains: - IPR029416: Cilia- and flagella-associated protein 300 (family) [11-262]
Interaction partners: - Cilia- and flagella-associated protein 298
- Dynein axonemal assembly factor 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0040012 (regulation of locomotion), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0032886 (regulation of microtubule-based process), GO:1902019 (regulation of cilium-dependent cell motility), GO:0030030 (cell projection organization), GO:0060632 (regulation of microtubule-based movement), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0001578 (microtubule bundle formation), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0003352 (regulation of cilium movement), GO:0060295 (regulation of cilium movement involved in cell motility), GO:0065003 (protein-containing complex assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0035082 (axoneme assembly), GO:0070286 (axonemal dynein complex assembly), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0003356 (regulation of cilium beat frequency), GO:0060271 (cilium assembly), GO:0036159 (inner dynein arm assembly), GO:0036158 (outer dynein arm assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium), GO:0036126 (sperm flagellum)
Protein: Mitosis inducer protein kinase cdr1 (EC 2.7.11.1) (Protein kinase nim1) (P07334)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it.
Sequence: MVKRHKNTIGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIRYASIGMEILMMRLLRHPNILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFRFRHRDLKLENILIKVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFLMGCTSLSSMDSTTPPTPSLSIDEIDPLVVDCMCVLWKKSSSKKVVRRLQQRDDNDEKYVYKVLSEILRDDMLKKQRFDENKYLSLYDLIHDNNLFTKASISTTSLVKSNVSTNSRKSSNFEDELARRVSSPLSALNQMSQSPIPIRVSSDKDYDSYACHEVVSNPSTLDDDYNYMFVCPPEEYTYSTDNVRTDSLDLQSLPTPTLEQLESVPFNRYGYVRIFPSTTLSSTASGYYTPDSLSTPEPSIDGLTNLDDVQVGGFVQGSGNQNRRPISFPVISNMQPNITNVRSASAPLCSSPVPSRRYSQYATNARYTPRKVSSGSVLRKISSFFRKD
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [12-259]
- IPR017441: Protein kinase, ATP binding site (binding_site) [18-41]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [124-136]
- IPR000719: Protein kinase domain (domain) [12-258]
Interaction partners: - Mitosis inhibitor protein kinase wee1
- M-phase inducer phosphatase
- Mitosis inducer protein kinase cdr2
- Mitosis inducer protein blt1
- Mitosis inhibitor nif1
- Protein arginine N-methyltransferase skb1
- Cyclin-dependent kinase 1
- Anillin-related medial ring protein mid1
- Rho guanine nucleotide exchange factor gef2
- Kinesin-like protein 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0006468 (protein phosphorylation), GO:0016310 (phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0060187 (cell pole), GO:0032153 (cell division site), GO:0051286 (cell tip)
Protein: SUMO1 activating enzyme subunit 1 (M0QYM8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRA
InterPro domains: - IPR045886: ThiF/MoeB/HesA family (family) [1-101]
- IPR000594: THIF-type NAD/FAD binding fold (domain) [1-112]
- IPR035985: Ubiquitin-activating enzyme-like (homologous_superfamily) [2-115]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140657 (ATP-dependent activity), GO:0016874 (ligase activity), GO:0008641 (ubiquitin-like modifier activating enzyme activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016877 (ligase activity, forming carbon-sulfur bonds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0018193 (peptidyl-amino acid modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0018205 (peptidyl-lysine modification), GO:0032446 (protein modification by small protein conjugation), GO:0016925 (protein sumoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)