Protein: PCI domain-containing protein (Q38BZ4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MDLPIELLLGSAPERQRYLRAVHILFNSVGDALKANARQQLLMATANDLTRGLSVADFCQFRRKCFENEDWCKCVYPLLEQDENVVADRAEAAVQEALSAVRFPGGGESSTEPVLVFLSTSKRSRSEIAEEFEIPGKLRLAEVFANVGDYGAMYDTLTHLFVPLQSGLQLTARSHRLPLLLLQLQVIKRTTELWLGAGNVEAVRGYVGESTSTVLTDAVQAIAVENGSGSVYFPSHQVTVEAVTDEIEQLLLFFSIVRALCLFESGDFCGFVCSFTPEGLRGTNWAQAAGDMLVERGATQVAASFGGRISRPGVLPVIHNLRRVVEESVTTGVQLGAMLLLSAVATRPRAEAMELVTRIDIMQLWEDIPEAHTLVHALQQANFADALHAASVLAFVYLKTDLFAYKHCECLLYQYKQTVIMRYVSCFISLDLKRAAMHLSIPLRELVHIVRELIEKEHISAKIDLVAYMLVSADAFSPTDTAATDRNLLFDCINRSRKCAEELEQSLRLLSAQRDNASSGVEFGP
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [401-474]
- IPR000717: Proteasome component (PCI) domain (domain) [400-471]
- IPR019585: 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 (family) [329-522]
Interaction partners: - COP9 signalosome complex subunit 4
- COP9 signalosome complex subunit 2, putative
- JAB1/MPN/MOV34 metalloenzyme domain-containing protein
- COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein
- COP9 signalosome complex subunit 5
- COP9 signalosome complex subunit 7
- Ubiquitin, putative
- DNA damage-binding protein 1
- RING-type domain-containing protein
- RING-type domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)