Protein: G-protein coupled receptor family C group 6 member A (Q70VB1)
Organism: Rattus norvegicus (Rat)
Function: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids (By similarity).
Subcellular location: Cell membrane {ECO:0000269|PubMed:17478059}; Multi-pass membrane protein {ECO:0000269|PubMed:17478059}.
Sequence: MALSFVFITCFMILLDTSQSCHTPDDFVAITSPGHIMIGGLFAIHEKMLSSDDHPRQPQIQKCVGFEISVFLQTLAMIHSIEMINNSSLLSGVKLGYEIYDTCTEVTAAMAATLRFLSKFNCSRETVIFQCDYSSYVPRVKAIIGAGYSEISMAVSRMLNLQLMPQVSYESTAEILSDKIRFPSFLRTVPSDFYQTKAMAHLIRQSGWNWVGAITTDDDYGRLALNTFAIQAAENNVCIAFKEVLPAFLSDNTIEVRINQTLEKIIAEAQVNVIVVFLRKFHVFNLFNKAIERKISKIWIASDNWSTAAKIITIPNVKKLGKVVGFTFRRGNMSSFHSFLQTLHMYPSDNNKPLHEFAMLFSACKHIKDGDLSQCISNYSQATWTYDTTKTIETHLFKRNDFLWHYTEPGLIHSIQLAVLALGHAIRDLCQDRDCQKPNAFQPWELLAVLKNVTFTDGKNSFHFDAHGDLNTGYEVVLWKETNGLMTVTKMAEYDLQHDVFITTNQETKHEFRKLKQILSKCSKECIPGQMKKATGSQHSCCYECVNCPENHYSNETDMDHCLVCNNETHWAPVRSTMCFEKEVEYLDWDDSLALLLIALSLLGIAFVLAVGIIFTRNLKTPVVKSSGGLVVCYVMLACHALNFASTGFFIGEPQDFTCKTRQTLFGVSFTLCVSCILTKSLKILLAFSFDPTLKTFLKCLYRPVPIVLTCTGIQVVICTLWLVLAAPTVEENTSLPRVIILECEEGSALAFGTMLGYIAVLAFICFVFAFKGRKLPENYNEAKFLTFGMLIYFIAWITFIPVYATTFGKYLPAVEIIVILISNYGILCCTFFPKCYIILCKQKTNTKSVFLQMVYNYSAHSVDSLALSHVSLDSASHSTATTNPRPGNKTAACQNYKHLPVQVLAHTGMEKTMHASKTLHQKRSSSI
InterPro domains: - IPR000337: GPCR, family 3 (family) [33-802]
- IPR011500: GPCR, family 3, nine cysteines domain (domain) [519-570]
- IPR017978: GPCR family 3, C-terminal (domain) [587-849]
- IPR017979: GPCR, family 3, conserved site (conserved_site) [541-565]
- IPR000068: GPCR, family 3, extracellular calcium-sensing receptor-related (family) [30-853]
- IPR001828: Receptor, ligand binding region (domain) [75-481]
- IPR038550: GPCR, family 3, nine cysteines domain superfamily (homologous_superfamily) [518-595]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [29-496]
Interaction partners: - Extracellular calcium-sensing receptor
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
- Osteocalcin
- Metabotropic glycine receptor
- Solute carrier family 15 member 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0043200 (response to amino acid), GO:0010243 (response to organonitrogen compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)