wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: BZIP domain-containing protein (A7SDE7)
Organism: Nematostella vectensis (Starlet sea anemone)
Function: Not known
Sequence: DDEYIRKRERNNEAVRKSRKKAKQRIQETQQRVTELSKENEELRSKVTLLQKELSVLRSLF
InterPro domains: - IPR031106: CCAAT/enhancer-binding protein C/EBP (family) [2-61]
- IPR004827: Basic-leucine zipper domain (domain) [1-61]
- IPR046347: Basic-leucine zipper domain superfamily (homologous_superfamily) [1-61]
Interaction partners: - Protein kinase domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0051054 (positive regulation of DNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex, 10, 42kDa, isoform CRA_c (NADH:ubiquinone oxidoreductase subunit A10) (NDUFA10 protein) (Q8N1B9)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCESALQTHFWVCGATLQGL
InterPro domains: - IPR031314: Deoxynucleoside kinase domain (domain) [60-182]
- IPR050566: Deoxyribonucleoside Kinase (family) [16-191]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [56-199]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016776 (phosphotransferase activity, phosphate group as acceptor), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0050145 (nucleoside monophosphate kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Macrophage receptor with collagenous structure (M0R9F7)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Sequence: MGSKETLKEEAFLGSTEDGADFDQDMLPVMETFEINDPVPKKRNGRTLCMAVMAIHLILLTAGTALLLIQVLNLQEQFQSLEMCCDNGTLAAEDKPFFSLQWARPKTHIVSGAQGLQALQAQLSWVHTSQEQLRQQVDNLTQNPELFRIKGERGSPGPKGAPGAPGIPGLPGPSAAKGEKGAAGRDGTPGVRGPQGPPGTKGEAGLQGFTGAPGKQGADGAPGPQGEKGSKGDKGLTGPKGEHGTKGDKGDLGLPGSKGDTGMKGDRGVTGSPGAQGNKGDAGKPGLPGLAGSPGAKGDQGKLGVQGPPGPPGAPGQSGAKGEPGRTGPPGPTGPPGIAGNPGAAGLKGSKGDIGIQGQKGTKGESGVPGLVGRKGDTGSPGLAGPKGEPGRAGLKGEPGMKGSSGQQGQKGEKGQKGDFNLVVRIVGGTSRGRAEVYYNNVWGTICDDGWDNNDATVFCRMLGYSSGRGLGSFGGGTGKIWLDDVSCLGTEATLWDCRKSSWGSHNCNHNEDAGVECR
InterPro domains: - IPR050149: Collagen superfamily (family) [150-418]
- IPR001190: SRCR domain (domain) [422-519]
- IPR036772: SRCR-like domain superfamily (homologous_superfamily) [420-519]
- IPR008160: Collagen triple helix repeat (repeat) [151-308]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0038024 (cargo receptor activity), GO:0005044 (scavenger receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Cytochrome b-c1 complex catalytic subunit, mitochondrial (EC 7.1.1.8) (Complex III catalytic subunit) (A0A1D8PHA3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07143}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MFRTAYKTMNQSMVQKFIAGGVGVTGLTASYLLYQDSMTADAMTAAEHGLHPPAYNWPHNGMFETFDHASIRRGFQVYREVCAACHSLDRIAWRNLVGVSHTTSEAKAMAEELEYDDEPDDEGKPRKRPGKLADYIPGPYENEQAARAANQGAYPPDLSLIVKARHGGSDYIFSLLTGYPDEPPAGVVLPEGSNYNPYFPGGAIAMGRVLFDDLVEYEDGTPATTSQMAKDVSTFLNWASEPEHDDRKKWGLKALVVLSSLYLLSIWVKRFKWTPIKNRKFRFDPPKK
InterPro domains: - IPR009056: Cytochrome c-like domain (domain) [69-222]
- IPR036909: Cytochrome c-like domain superfamily (homologous_superfamily) [44-242]
- IPR021157: Cytochrome c1, transmembrane anchor, C-terminal (homologous_superfamily) [242-287]
- IPR002326: Cytochrome c1 (family) [8-284]
Interaction partners: - Cytochrome b
- NADH dehydrogenase flavoprotein 1, mitochondrial
- Cytochrome b-c1 complex subunit 8, mitochondrial
- Cytochrome b-c1 complex subunit 9, mitochondrial
- NAD-dependent epimerase/dehydratase domain-containing protein
- NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial
- Fesur1p
- Cytochrome b-c1 complex subunit 2, mitochondrial
- Cytochrome c oxidase subunit Va
- Cytochrome c oxidase subunit 6, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0016679 (oxidoreductase activity, acting on diphenols and related substances as donors), GO:0022804 (active transmembrane transporter activity), GO:0015399 (primary active transmembrane transporter activity), GO:0003954 (NADH dehydrogenase activity), GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor), GO:0050136 (NADH dehydrogenase (quinone) activity), GO:0015453 (oxidoreduction-driven active transmembrane transporter activity), GO:0003955 (NAD(P)H dehydrogenase (quinone) activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006122 (mitochondrial electron transport, ubiquinol to cytochrome c)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Sporulation sigma-E factor-processing peptidase (EC 3.4.23.-) (Membrane-associated aspartic protease) (Stage II sporulation protein GA) (P13801)
Organism: Bacillus subtilis (strain 168)
Function: Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1744037, ECO:0000269|PubMed:18378688, ECO:0000269|PubMed:9663680}; Multi-pass membrane protein {ECO:0000269|PubMed:1744037, ECO:0000269|PubMed:18378688, ECO:0000269|PubMed:9663680}. Note=Localized to the sporulation septum.
Sequence: MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGSSIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGIIGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQYEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIRNTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKCLIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS
InterPro domains: - IPR005081: Sigma-E processing peptidase SpoIIGA (family) [1-302]
Interaction partners: - Stage II sporulation protein R
- Stage II sporulation protein E
- RNA polymerase sigma-E factor
- Anti-sigma F factor
- Anti-sigma F factor antagonist
- RNA polymerase sigma-G factor
- Stage III sporulation protein D
- Stage III sporulation protein AA
- RNA polymerase sigma-F factor
- Stage II sporulation protein M
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0008219 (cell death), GO:0012501 (programmed cell death)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: NAD(P)H-quinone oxidoreductase subunit K, chloroplastic (EC 7.1.1.-) (NAD(P)H dehydrogenase subunit K) (NADH-plastoquinone oxidoreductase subunit K) (P56756)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Subcellular location: Plastid, chloroplast thylakoid membrane {ECO:0000255|HAMAP-Rule:MF_01356}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01356}; Stromal side {ECO:0000255|HAMAP-Rule:MF_01356}.
Sequence: MNSIKFPILDRTTKNSVISTTLNDLSNWSRLSSLWPLLYGTSCCFIEFASLIGSRFDFDRYGLVPRSSPRQADLILTAGTVTMKMAPSLVRLYEQMPEPKYVIAMGACTITGGMFSTDSYSTVRGVDKLIPVDVYLPGCPPKPEAVIDAITKLRKKIAREIYKDRIRPQQGNRCFTTNHKFFVVRSPHIGNYDQELLYPPSSTSEISTETFFKYKSPVSSHELVN
InterPro domains: - IPR006138: NADH-ubiquinone oxidoreductase, 20 Kd subunit (family) [7-159]
- IPR006137: NADH:ubiquinone oxidoreductase-like, 20kDa subunit (domain) [43-153]
Interaction partners: - NAD
- NAD
- NAD
- NAD
- NAD
- NAD
- Photosystem I iron-sulfur center
- NAD
- NAD
- NAD
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration), GO:0019646 (aerobic electron transport chain), GO:0009060 (aerobic respiration), GO:0042773 (ATP synthesis coupled electron transport), GO:0006120 (mitochondrial electron transport, NADH to ubiquinone), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006119 (oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Large ribosomal subunit protein uL6x (60S ribosomal protein L9-2) (Q9SZX9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MKTILSSETMDIPDGVAIKVNAKVIEVEGPRGKLTRDFKHLNLDFQLIKDQVTGKRQLKIDSWFGSRKTSASIRTALSHVDNLIAGVTQGFLYRMRFVYAHFPINASIDGNNKSIEIRNFLGEKKVRKVEMLDGVKIVRSEKVKDEIILEGNDIELVSRSCALINQKCHVKKKDIRKFLDGIYVSEKGKIAVEE
InterPro domains: - IPR036789: Large ribosomal subunit protein uL6-like, alpha-beta domain superfamily (homologous_superfamily) [1-194]
- IPR000702: Large ribosomal subunit protein uL6-like (family) [1-190]
- IPR002359: Large ribosomal subunit protein uL6, conserved site-2 (conserved_site) [166-187]
- IPR020040: Large ribosomal subunit protein uL6, alpha-beta domain (domain) [12-181]
Interaction partners: - Large ribosomal subunit protein eL32z
- Large ribosomal subunit protein uL23y
- Large ribosomal subunit protein uL4y
- Large ribosomal subunit protein eL8y
- Large ribosomal subunit protein uL18y
- Large ribosomal subunit protein uL4z
- Large ribosomal subunit protein uL23z
- Large ribosomal subunit protein eL31z
- Large ribosomal subunit protein uL22y
- Large ribosomal subunit protein uL22z
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0003735 (structural constituent of ribosome), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009266 (response to temperature stimulus), GO:0009409 (response to cold)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0055044 (symplast), GO:0030054 (cell junction), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0031967 (organelle envelope), GO:0043229 (intracellular organelle), GO:0022626 (cytosolic ribosome), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0044391 (ribosomal subunit), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0009506 (plasmodesma), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0022625 (cytosolic large ribosomal subunit), GO:0009526 (plastid envelope), GO:0070013 (intracellular organelle lumen), GO:0015934 (large ribosomal subunit), GO:0005911 (cell-cell junction), GO:0005730 (nucleolus), GO:0009941 (chloroplast envelope), GO:0005840 (ribosome), GO:0005634 (nucleus), GO:0031981 (nuclear lumen)
Protein: LP06328p (Q8MZG9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MSAPTDYLFCPLAYGSALSAIGIYLLRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDGFEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRDDLNSEKSYDRKMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPGVVNTELFRNTPFLGSWFGKLLIAPIIWIFIKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEKWTGINI
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [42-298]
- IPR002347: Short-chain dehydrogenase/reductase SDR (family) [44-244]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0004033 (aldo-keto reductase (NADP) activity), GO:0008106 (alcohol dehydrogenase (NADP+) activity), GO:0052650 (NADP-retinol dehydrogenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0051235 (maintenance of location), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0044255 (cellular lipid metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006629 (lipid metabolic process), GO:0019915 (lipid storage), GO:0120254 (olefinic compound metabolic process), GO:0006081 (cellular aldehyde metabolic process), GO:0022607 (cellular component assembly), GO:0008104 (protein localization), GO:0006720 (isoprenoid metabolic process), GO:0140042 (lipid droplet formation), GO:0006996 (organelle organization), GO:0042574 (retinal metabolic process), GO:0070925 (organelle assembly), GO:0033365 (protein localization to organelle), GO:0034389 (lipid droplet organization), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0140694 (non-membrane-bounded organelle assembly), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)
Protein: Chemokine-like factor (C32) (Q9UBR5)
Organism: Homo sapiens (Human)
Function: May play an important role in inflammation and regeneration of skeletal muscle. Essential for embryonic development (By similarity).
Subcellular location: [Isoform 1]: Secreted {ECO:0000269|PubMed:11415443, ECO:0000269|PubMed:16137713}.; SUBCELLULAR LOCATION: [Isoform 2]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MDNVQPKIKHRPFCFSVKGHVKMLRLALTVTSMTFFIIAQAPEPYIVITGFEVTVILFFILLYVLRLDRLMKWLFWPLLDIINSLVTTVFMLIVSVLALIPETTTLTVGGGVFALVTAVCCLADGALIYRKLLFNPSGPYQKKPVHEKKEVL
InterPro domains: - IPR008253: Marvel domain (domain) [13-133]
- IPR050578: MARVEL domain-containing and chemokine-like factor proteins (family) [13-127]
Interaction partners: - CKLF-like MARVEL transmembrane domain-containing protein 2
- CKLF-like MARVEL transmembrane domain-containing protein 3
- CKLF-like MARVEL transmembrane domain-containing protein 7
- CKLF-like MARVEL transmembrane domain-containing protein 4
- CKLF-like MARVEL transmembrane domain-containing protein 6
- CKLF-like MARVEL transmembrane domain-containing protein 5
- CKLF-like MARVEL transmembrane domain-containing protein 8
- Plasmolipin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0045321 (leukocyte activation), GO:0001775 (cell activation), GO:0002274 (myeloid leukocyte activation), GO:0045576 (mast cell activation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005769 (early endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0012506 (vesicle membrane), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0031901 (early endosome membrane)