Protein: Adenylyl cyclase-associated protein (Q5A6P9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control
Sequence: MSTEESQFNVQGYNIITILKRLEAATSRLEDITIFQEEANKNHYGVDSLTEKGTPKSRTVESSEATSDGKSLESTSFATFSEAPVEKSKLIVEFENFVESYVHPLVETSKKIDSLVGESAQYFYEAFVEQGKFLELVLQSQQPDMTDPALAKALEPMNAKCTKINELKDSNRKSPFFNHLSTFSESNAVFYWIGIPTPVSYITDTKDTVKFWSDRVLKEYKTKDQVHVEWVKQTLSVFDELKNYVKEYHTTGVAWNPKGKPFAEVVSQQTESAAKNSSSASGSAGGAAPPPPPPPPPATFFDDTEKDSENPSPASGGINAVFAELNQGANITSGLKKVDKSEMTHKNPELRKQPPVAPKKPAPPKKPSSLSGGVSSAPVKKPAKKELIDGTKWIIQNFTKADISDLSPITIEVEMHQSVFIGNCSDVTIQLKGKANAVSVSETKNVALVIDSLISGVDVIKSYKFGIQVLGLVPMLSIDKSDEGTIYLSQESIDNDSQVFTSSTTALNINAPKENDDYEELAVPEQFVSKVVNGKLVTQIVEHAG
InterPro domains: - IPR036223: Adenylate cyclase-associated CAP, C-terminal superfamily (homologous_superfamily) [388-545]
- IPR036222: Adenylate cyclase-associated CAP, N-terminal domain superfamily (homologous_superfamily) [91-297]
- IPR053950: CAP, N-terminal domain (domain) [94-253]
- IPR013992: Adenylate cyclase-associated CAP, N-terminal (conserved_site) [17-69]
- IPR017901: C-CAP/cofactor C-like domain (domain) [382-523]
- IPR006599: CARP motif (domain) [424-499]
- IPR018106: CAP, conserved site, N-terminal (conserved_site) [18-30]
- IPR016098: Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal (homologous_superfamily) [382-545]
- IPR001837: Adenylate cyclase-associated CAP (family) [17-545]
- IPR013912: Adenylate cyclase-associated CAP, C-terminal (domain) [381-543]
Interaction partners: - Abp1p
- Adenylate cyclase
- Cofilin
- Actin
- Profilin
- ADF-H domain-containing protein
- Centractin
- Uncharacterized protein
- Pho81p
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding), GO:0008179 (adenylate cyclase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009628 (response to abiotic stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0045927 (positive regulation of growth), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0050790 (regulation of catalytic activity), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0035556 (intracellular signal transduction), GO:0080134 (regulation of response to stress), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0010570 (regulation of filamentous growth), GO:0009268 (response to pH), GO:0090033 (positive regulation of filamentous growth), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0051339 (regulation of lyase activity), GO:0036176 (response to neutral pH), GO:0034605 (cellular response to heat), GO:0031279 (regulation of cyclase activity), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:0071467 (cellular response to pH), GO:0019932 (second-messenger-mediated signaling), GO:0070784 (regulation of growth of unicellular organism as a thread of attached cells), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0045761 (regulation of adenylate cyclase activity), GO:0036244 (cellular response to neutral pH), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0019933 (cAMP-mediated signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0030427 (site of polarized growth), GO:0060187 (cell pole), GO:0051286 (cell tip), GO:0001411 (hyphal tip)