Protein: Transcription factor Sp7 (Q6U1J4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences
Subcellular location: Nucleus
Sequence: MAASILEEETRYGSSPLAMLTATCNKFGSTSPVRDSATPGKPGSTIPIKKAYSMTSELQSAKNGRNESVADSYTGSFSSSGGLLTPTGSPPPAPTGAYGSEYNPFSTFQTSSVSQDPSLLGSKATADCLTSVNTYLDMTHPYGSWYKGIHPGITASPANATSSWWDVHTNANWLSPGQAQPDSLQAPLQPVAPQASLNPQMPSYTPDFTPLNPAPYPSVGLSSSSHLLQSSQHMLPQDMYKPKPVPTSGILDNSMGLKSARGSGYAAGSTTGRSSCDCPNCQELERLGASAASLRKKPVHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCNKRFTRSDHLSKHQKTHSEASLQGKEEPETRAEESSADKVAPAGSEIGIQEPAVGGEEKSSTGNGVDSGSGLLEI
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [300-387]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [314-383]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0001503 (ossification), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0009887 (animal organ morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:1904888 (cranial skeletal system development), GO:0030154 (cell differentiation), GO:0001649 (osteoblast differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0097094 (craniofacial suture morphogenesis), GO:0060349 (bone morphogenesis), GO:0033688 (regulation of osteoblast proliferation), GO:0048705 (skeletal system morphogenesis), GO:0060348 (bone development), GO:0001501 (skeletal system development), GO:0042476 (odontogenesis), GO:0042475 (odontogenesis of dentin-containing tooth)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)