Protein: non-specific serine/threonine protein kinase (Q563W7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein. Nucleus
Sequence: MSQKSWIEHTFTRRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHVGFTATLAVKYSEVSEELSELEQWSVEKHTEESPTDAYGVINFQGGSHSYRAKYVRLSHDSRPEAVLRLMLKEWLMELPKIVISVHGGIQNFELHPRIKQVVGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHLSRSARKICTVGIAPWGVIENRNDLIGRDVVAPYQTLLNPLSKLNVLNNFHSHFLLVDDGTVGKYGAEVRLRRELEKHIQLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILAYVHKQTEQDGALPDGVESDIIATIKKTFNFSHGDALHLFQTLMECMKNKELITVFPVGSEDHQDIDVAILKALLKGTNATAFDQLVLTLAWDRVDIAKDHVFVYGQQLLVGSLEQAMLDALVMDRVEFVKLLIENGVSMHRFLTITRLEELYNTKQTPTNPTLYHLVRDVKQGNLPPNYKITLIDVGLVIEYLMGGTYRCNYTRKRFRIIYNNLHGNSRRSGRHTSSSHSHESFSIQADKKEKTRHNHFIKTAQPYKPRLDSVSELQKKKSKEEVVDVDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEESMAKALVACRLLRSLGDEAKKSDVVDDTSEELKEYSSEFGTLAVDLLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQSQDAHQSMEDSEHNLQHPDDIQMDVFKEVRMSDNAEMKSELEVHVRSRRLPITRKFYAFYHAPIVKFWFNTLFYIGFLMLYSFVVLVKMQDLPSPQEWVVILYIFTLAVEKIREMFMSEGGKISQKIKVWFSDYFNISDFLAILMFFVGFGLRLVSEVFIAGRIVYCLNIIFWYVRLLDILAVNQQAGPYVMMIGKMVANMFYIVVIMAVVLLSFGVPRKAILYPEEEPSWTLAKDVVFQPYWMMYGEVYAYEIDVCANSSEEHVRDLCTTGVWLTPLLQAVYLFVQYILMVNLLIAFFNNVYLQVKSISNLVWKYQRYHFILAYHDKPILPPPLILLSHAASLLSSICRKRKKDSSTYGPKLFLTEEDQKKLHDFEEQCVETYFHEKDDQFHSGSDERIRLTSDRVETMCVQLKEVGNKVNFIKRSLHTLDSQIGHLQDLSALTVDTLKALTAQRASEASKVHNQITRELSVSRNLAPEAVPPSKPGALVRCSVAFMPPNSMADSLFGGGVEAVQGAGLPHASLTADGVQTPQMRRRGHQEHLSSAPAAAASFFLSTPLPQQQDLQAPPEEFGAFVGHKDEPEGQRSIPKESAVSSPSRKTRDVGNMRTVNSYAGFTELDRNPSLLHPESTLSKQERTRVSLEDVSRYEDLLLGKSAQSSKLSPGDDASNTAIGSPFKPMESYQYSAVERNNLMRLSQSIPFTPVPPRGEPVSVYRLEESSPGSINNSMSSWAQRGLCAKIEFLSKEEMGGGLRRALKVLCTWSEYDILKPGHLYIVKSFLPEVVNTWQTIYREETVLHLCLREIQQQRAAQKLTFAFNQIRPKTIPYSPRFLEVFLLYCHSAGQWFAIEECITGDFRKFNNNNGDEIVPTNLLEETMLAFSHWTYEYTRGELLVLDLQGVGEILTDPSVIKSGEKGSYDMIFGPANLGDDAIRNFRAKHHCNSCCRKLKLPDLKRNDYTPDKLTLQHDPSEGPSHSPPAGAATKELRPSMRLML
InterPro domains: - IPR029601: Transient receptor potential cation channel subfamily M member 7, alpha-kinase domain (domain) [1489-1727]
- IPR057366: TRPM-like domain (domain) [548-727]
- IPR032415: TRPM, tetramerisation domain (domain) [1175-1230]
- IPR004166: Alpha-type protein kinase, alpha-kinase domain (domain) [1503-1733]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1463-1738]
- IPR005821: Ion transport domain (domain) [846-1085]
- IPR050927: Transient receptor potential cation channel M (family) [1-1342]
- IPR037162: TRPM, tetramerisation domain superfamily (homologous_superfamily) [1176-1230]
- IPR041491: TRPM, SLOG domain (domain) [103-368]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005227 (calcium activated cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0032501 (multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0048869 (cellular developmental process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0042440 (pigment metabolic process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0001503 (ossification), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0048066 (developmental pigmentation), GO:0003008 (system process), GO:0050801 (monoatomic ion homeostasis), GO:0051726 (regulation of cell cycle), GO:1901615 (organic hydroxy compound metabolic process), GO:1903530 (regulation of secretion by cell), GO:1901360 (organic cyclic compound metabolic process), GO:0002027 (regulation of heart rate), GO:0042127 (regulation of cell population proliferation), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0003014 (renal system process), GO:0001505 (regulation of neurotransmitter levels), GO:0050931 (pigment cell differentiation), GO:0098771 (inorganic ion homeostasis), GO:0006725 (cellular aromatic compound metabolic process), GO:0099177 (regulation of trans-synaptic signaling), GO:0006582 (melanin metabolic process), GO:0051588 (regulation of neurotransmitter transport), GO:0007346 (regulation of mitotic cell cycle), GO:0046928 (regulation of neurotransmitter secretion), GO:0055080 (monoatomic cation homeostasis), GO:0055123 (digestive system development), GO:0001501 (skeletal system development), GO:0010960 (magnesium ion homeostasis), GO:0050804 (modulation of chemical synaptic transmission), GO:0048732 (gland development), GO:0030318 (melanocyte differentiation), GO:0051046 (regulation of secretion), GO:0035272 (exocrine system development), GO:0006811 (monoatomic ion transport), GO:0050678 (regulation of epithelial cell proliferation), GO:1903522 (regulation of blood circulation), GO:0031016 (pancreas development), GO:0018958 (phenol-containing compound metabolic process), GO:0031017 (exocrine pancreas development), GO:0008016 (regulation of heart contraction), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)