Protein: Integrin beta-1 (CSAT antigen) (JG22 antigen) (RGD-receptor) (P07228)
Organism: Gallus gallus (Chicken)
Function: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis.
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P05556}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:P05556}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P05556}; Single-pass type I membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:P05556}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P05556}. Cell projection, ruffle {ECO:0000250|UniProtKB:P05556}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P05556}.
Sequence: MAETNLTLLTWAGILCCLIWSGSAQQGGSDCIKANAKSCGECIQAGPNCGWCKKTDFLQEGEPTSARCDDLAALKSKGCPEQDIENPRGSKRVLEDREVTNRKIGAAEKLKPEAITQIQPQKLVLQLRVGEPQTFSLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTALMREMEKITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTGDQNCTSPFSYKNVLSLTSEGNKFNELVGKQHISGNLDSPEGGFDAIMQVAVCGDQIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGKCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQAVYKELKNLIPKSAVGTLSSNSSNVIQLIIDAYNSLSSEVILENSKLPKEVTISYKSYCKNGVNDTQEDGRKCSNISIGDEVRFEINVTANECPKKGQNETIKIKPLGFTEEVEIHLQFICDCLCQSEGEPNSPACHDGNGTFECGACRCNEGRIGRLCECSTDEVNSEDMDAYCRRENSTEICSNNGECICGQCVCKKRENTNEVYSGKYCECDNFNCDRSNGLICGGNGICKCRVCECFPNFTGSACDCSLDTTPCMAGNGQICNGRGTCECGTCNCTDPKFQGPTCEMCQTCLGVCAEHKDCVQCRAFEKGEKKETCSQECMHFNMTRVESRGKLPQPVHPDPLSHCKEKDVGDCWFYFTYSVNSNGEASVHVVETPECPSGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
InterPro domains: - IPR014836: Integrin beta subunit, cytoplasmic domain (domain) [757-803]
- IPR016201: PSI domain (domain) [30-80]
- IPR033760: Integrin beta N-terminal (domain) [30-80]
- IPR013111: Epidermal growth factor-like domain, extracellular (domain) [604-635]
- IPR012896: Integrin beta subunit, tail (domain) [644-733]
- IPR057243: Integrins beta, I-EGF domain, conserved site (conserved_site) [612-625]
- IPR002369: Integrin beta subunit, VWA domain (domain) [38-469]
- IPR040622: Integrin beta, epidermal growth factor-like domain 1 (domain) [471-500]
- IPR057073: Integrin beta, epidermal growth factor-like domain 2 (domain) [516-559]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [357-473]
- IPR036349: Integrin beta tail domain superfamily (homologous_superfamily) [643-731]
- IPR015812: Integrin beta subunit (family) [1-803]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [142-384]
Interaction partners: - Integrin alpha-6
- Integrin subunit alpha 4
- Integrin alpha-V
- Integrin alpha-1
- Integrin subunit alpha 7
- Focal adhesion kinase 1
- Integrin alpha-8
- Laminin subunit gamma 1.
- Integrin subunit alpha 2
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0001968 (fibronectin binding), GO:0046983 (protein dimerization activity), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0045597 (positive regulation of cell differentiation), GO:0044085 (cellular component biogenesis), GO:0098609 (cell-cell adhesion), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0031589 (cell-substrate adhesion), GO:0016477 (cell migration), GO:0007160 (cell-matrix adhesion), GO:1902903 (regulation of supramolecular fiber organization), GO:0032233 (positive regulation of actin filament bundle assembly), GO:0022604 (regulation of cell morphogenesis), GO:0030030 (cell projection organization), GO:0031344 (regulation of cell projection organization), GO:0042692 (muscle cell differentiation), GO:0031346 (positive regulation of cell projection organization), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0048858 (cell projection morphogenesis), GO:0006996 (organelle organization), GO:0051147 (regulation of muscle cell differentiation), GO:0010638 (positive regulation of organelle organization), GO:0001667 (ameboidal-type cell migration), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0060297 (regulation of sarcomere organization), GO:0110020 (regulation of actomyosin structure organization), GO:0051493 (regulation of cytoskeleton organization), GO:0051491 (positive regulation of filopodium assembly), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0051153 (regulation of striated muscle cell differentiation), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060298 (positive regulation of sarcomere organization), GO:0044782 (cilium organization), GO:0043542 (endothelial cell migration), GO:0051155 (positive regulation of striated muscle cell differentiation), GO:0110020 (regulation of actomyosin structure organization), GO:0051493 (regulation of cytoskeleton organization), GO:0051146 (striated muscle cell differentiation), GO:1902745 (positive regulation of lamellipodium organization), GO:0031175 (neuron projection development), GO:0001954 (positive regulation of cell-matrix adhesion), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:1902743 (regulation of lamellipodium organization), GO:0010591 (regulation of lamellipodium assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0014902 (myotube differentiation), GO:0061564 (axon development), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0043235 (receptor complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098636 (protein complex involved in cell adhesion), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:0008305 (integrin complex), GO:0005886 (plasma membrane)