wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Homeobox protein engrailed-2b (Homeobox protein en-2b) (Zf-En-1) (P31533)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus.
Sequence: MEENDHSNRDVERQDSGDESNRAILPLLQAPGNVLPHRITNFYIDNILRPDFGRRKEGSRRDEINIVERENRCPSAPGSGQVAPVSGEGTSSPRAVNASKKTDISTDESLKSRAETGDQCLSSDSDCSQRCAAQAKQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKTPTKEDKRPRTAFTAEQLQRLKNEFQNNRYLTEQRRQALAQELGLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHATVTKDDKSDSD
InterPro domains: - IPR001356: Homeodomain (domain) [170-234]
- IPR000747: Homeodomain engrailed (domain) [171-251]
- IPR019549: Homeobox engrailed, C-terminal (domain) [230-259]
- IPR020479: Homeodomain, metazoa (domain) [194-228]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [168-230]
- IPR017970: Homeobox, conserved site (conserved_site) [205-228]
- IPR000047: Helix-turn-helix motif (conserved_site) [201-226]
- IPR050720: Engrailed Homeobox Transcription Factors (family) [10-260]
- IPR019737: Homeobox engrailed-type, conserved site (conserved_site) [241-248]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0060384 (innervation), GO:0032989 (cellular component morphogenesis), GO:0021675 (nerve development), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 15 (OsPIL15) (PIF-like protein 15) (Basic helix-loop-helix protein 105) (OsbHLH105) (Q0JNI9)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Transcription factor that may act as negative regulator of phyB-dependent light signal transduction.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:21549224}.
Sequence: MSDGNDFAELLWENGQAVVHGRKKHPQPAFPPFGFFGGTGGGGGGSSSRAQERQPGGIDAFAKVGGGFGALGMAPAVHDFASGFGATTQDNGDDDTVPWIHYPIIDDEDAAAPAALAAADYGSDFFSELQAAAAAAAAAAPPTDLASLPASNHNGATNNRNAPVATTTTREPSKESHGGLSVPTTRAEPQPQPQLAAAKLPRSSGSGGGEGVMNFSLFSRPAVLARATLESAQRTQGTDNKASNVTASNRVESTVVQTASGPRSAPAFADQRAAAWPPQPKEMPFASTAAAPMAPAVNLHHEMGRDRAGRTMPVHKTEARKAPEATVATSSVCSGNGAGSDELWRQQKRKCQAQAECSASQDDDLDDEPGVLRKSGTRSTKRSRTAEVHNLSERRRRDRINEKMRALQELIPNCNKIDKASMLDEAIEYLKTLQLQVQMMSMGTGLCIPPMLLPTAMQHLQIPPMAHFPHLGMGLGYGMGVFDMSNTGALQMPPMPGAHFPCPMIPGASPQGLGIPGTSTMPMFGVPGQTIPSSASSVPPFASLAGLPVRPSGVPQVSGAMANMVQDQQQGIANQQQQCLNKEAIQGANPGDSQMQIIMQGDNENFRIPSSAQTKSSQFSDGTGKGTNARERDGAET
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [384-439]
- IPR044273: Transcription factor PIF3-like (family) [2-596]
- IPR047265: Transcription factor PIF1-like, basic helix-loop-helix domain (domain) [384-446]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [379-443]
Interaction partners: - DELLA protein SLR1
- Phytochrome B
- Phytochrome A
- Protein SLENDER RICE1-LIKE 1
- Transcription factor APG
- Protein SLENDER RICE1-LIKE 2
- Helix-loop-helix DNA-binding domain containing protein, expressed
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: ADP-ribosylation factor (B5DG68)
Organism: Salmo salar (Atlantic salmon)
Function: Not known
Subcellular location: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555, ECO:0000256|RuleBase:RU369003}.
Sequence: MGNMFGSLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELQRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHALRQRSWYIQATCATSGDGLYEGLDWLSNQLKNQK
InterPro domains: - IPR024156: Small GTPase superfamily, ARF type (family) [1-176]
- IPR005225: Small GTP-binding domain (domain) [16-160]
- IPR006689: Small GTPase superfamily, ARF/SAR type (family) [1-177]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [8-181]
- IPR045872: ADP-ribosylation factor 1-5 (family) [18-176]
Interaction partners: - ADP-ribosylation factor 6
- ADP-ribosylation factor 6
- ADP-ribosylation factor
- ADP-ribosylation factor
- Intersectin-2-like
- AP complex subunit beta
- AP complex subunit beta
- Cell surface glycoprotein 1-like isoform X1
- Intersectin-1
- Intersectin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0006952 (defense response), GO:0043207 (response to external biotic stimulus), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0034097 (response to cytokine), GO:0034341 (response to type II interferon), GO:0071310 (cellular response to organic substance), GO:0071346 (cellular response to type II interferon), GO:0071345 (cellular response to cytokine stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Immunoglobulin heavy variable 1-46 (Ig heavy chain V-I region DOT) (Ig heavy chain V-I region HG3) (Ig heavy chain V-I region Mot) (P01743)
Organism: Homo sapiens (Human)
Function: V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Sequence: MDWTWRVFCLLAVAPGAHSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGIINPSGGSTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCAR
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [32-117]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [20-117]
- IPR050199: Immunoglobulin Heavy Variable (family) [13-117]
- IPR007110: Immunoglobulin-like domain (domain) [15-117]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [17-117]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0043207 (response to external biotic stimulus), GO:0009615 (response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0005886 (plasma membrane)
Protein: Putative metal ion transporter C17A12.14 (O13779)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MPSNTSRSVPTGFYYKQNARMQNRPRFSDRKHSSKSKHRFPVDPSLQPDEADEGTRLLGNSDSDLLEPPSEHSSNGEDDKDINNPPSMPSSVCSSPKSPHRHYESDEDIENISLPESHPEDIQRKEFETENGKNTRDQPSPLAEVSDFAISSPHVYPKSANSHDSHYEQFANNDVTESAVDDHPATRKLSRDELYLPISPNNAQEPKFSVLDEWTKKMVANFEEYSVEDVDKRRERNRKLSEPLLVNGRYRVRDRWAQFRKSEIEKPYRFTFFTDELPSTIHSHEMWELVHDGQSFEDLFHSGGTWWLDVSCPKEEEIRVLAKAFGIHPLTVEDITLEEDREKVELFRTYYFVTFRSFNQLPSNSEYLKPLNFYLVVFRDGIITFHMNPTPHPANVRRRIRQLNGYLTVNADWIAYALLDDTTDAFAPFIEQIEDEVDTIDSMILSIHYDHVMEVKPQERMLQRVGECRKLIMSLLRLLANKADVVRGLSKRCNESWQVAPRGEIALYLGDVQDHIVTMVQNLNHYEKILSRSHSNYLAQISINMTLVSNETNEVLSRLTILGTILIPLNLVTGLWGMNVKVPGQDVPGLGWFFSILGSLMIFAISSFILCKWYKVI
InterPro domains: - IPR002523: Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB (family) [305-610]
- IPR045863: CorA, transmembrane region (homologous_superfamily) [551-613]
- IPR045861: CorA, cytoplasmic domain (homologous_superfamily) [289-542]
- IPR044089: Magnesium transporter Alr1-like (family) [307-614]
Interaction partners: - Stretch-activated cation channel yam8
- Mitochondrial inner membrane magnesium transporter mrs2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015095 (magnesium ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0006816 (calcium ion transport), GO:0030001 (metal ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0098588 (bounding membrane of organelle), GO:0000322 (storage vacuole), GO:0000324 (fungal-type vacuole), GO:0098852 (lytic vacuole membrane), GO:0000329 (fungal-type vacuole membrane)
Protein: Disease resistance protein (TIR-NBS-LRR class) family (Disease resistance protein-like) (Q9FFS6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MASSSTHVRKYHVFPSFHGSDVRRKFLSHLRFHFAIKGIVAFKDQEIERGQRIGPELVQAIRESRVSLVVLSKNYPSSSWCLDELVEILKCKEDQEQIVMPIFYEIDPSDVRKQSGDFGKAFGKTCVGKTKEVKQRWTNALTEAANIGGEHSLNWTDEAEMIEKIVADVSNKLNVIPSRDFEEMVGLDAHLRKLDSLLCLNSDEVKMIGIWGPAGIGKTTIARALYNQLSTNFQFKCFMGNLKGSYKSIGVDNYDWKLNLQNQLLSKILNQNDVKTDHLGGIKDWLEDKKVLIVIDDVDDLEQLLALAKEPSWFGSGSRIIVTTKDKTIMKTLLVNDNNFYHVGYPTNKVALEILCLSAFQKSFPRDGFEELARKVAYLCGNLPLCLSVVGSSLRGQSKHRWKLQSDRLETSLDRKIEDVLKSAYEKLSKKEQVLFLHIACFFNNTYISVVKTLLADSNLDVRNGLKTLADKCLVHISRVDRIFMHPLLQQLGRYIVLEQSDEPEKRQFLVEAEEIRDVLANETGTGSVLGISFDMSKVSEFSISGRAFEAMRNLRFLRIYRRSSSKKVTLRIVEDMKYLPRLRLLHWEHYPRKSLPRRFQPERLVVLHMPHSNLEKLWGGIQSLTNLKNIDLSFSRKLKEIPNLSNATNLETLTLIKCSSLVELPSSISNLQKLKALMMFGCKMLKVVPTNINLVSLEKVSMTLCSQLSSFPDISRNIKSLDVGKTKIEEVPPSVVKYWSRLDQLSLECRSLKRLTYVPPSITMLSLSFSDIETIPDCVIRLTRLRTLTIKCCRKLVSLPGLPPSLEFLCANHCRSLERVHSFHNPVKLLIFHNCLKLDEKARRAIKQQRVEGYIWLPGKKVPAEFTHKATGNSITIPLAPVAGTFSVSSRFKACLLFSPIEDFPTNDITCRLRIKGGVQINKFYHRVVILESSKIRTEHLFIFYGDLFSEKIGVDVSTSEILFKFSCRDKHKIIECGVQIFKEEAESSSSSSEEEYFDAESSSNEEEYFDFESSSSSEEDYFDAESSSRECWRWRL
InterPro domains: - IPR035897: Toll/interleukin-1 receptor homology (TIR) domain superfamily (homologous_superfamily) [3-173]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [416-502]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [528-843]
- IPR042197: Apoptotic protease-activating factors, helical domain (homologous_superfamily) [347-429]
- IPR003593: AAA+ ATPase domain (domain) [204-340]
- IPR000157: Toll/interleukin-1 receptor homology (TIR) domain (domain) [9-186]
- IPR002182: NB-ARC (domain) [191-415]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [170-439]
- IPR044974: Disease resistance protein, plants (family) [10-821]
- IPR011713: Leucine-rich repeat 3 (repeat) [605-623]
Interaction partners: - Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D
- Diacylglycerol kinase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Zinc transporter 8 (ZRT/IRT-like protein 8) (OsZIP8) (A3BI11)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Zinc transporter that may mediate zinc uptake from the rhizosphere and may be responsible for the translocation of zinc within the plant.
Subcellular location: Cell membrane {ECO:0000269|PubMed:20496122}; Multi-pass membrane protein {ECO:0000269|PubMed:20496122}.
Sequence: MRTNTTATVLLAAAVALLLATAARGDGGDGGCGKEDAAAGRDRARARGLKIAAFFSILVCGALGCGLPSLGRHVPALRPDGDVFFLVKAFAAGVILATGFIHILPDAFDNLTDDCLPAGGPWKEFPFAGFGAMVGAIGTLVVDTLATGYFTRALSKKDAATAAAVADEEKQSAAATQQHNHHHNHHVVGDGGGGGEEHEGQVHVHTHATHGHAHGSSALVAAVGEDDKETTLRHRVISQVLELGIVVHSVIIGISLGASQNPETIKPLVVALSFHQMFEGMGLGGCIVQAKFKVRSIVTMVLFFCLTTPVGIAVGVGISSVYNESSPTALVVEGILNSVAAGILIYMALVDLLAEDFMNPRVQSKGKLQLGINLAMLAGAGLMSMLAKWA
InterPro domains: - IPR003689: Zinc/iron permease (family) [48-387]
- IPR004698: Zinc/iron permease, fungal/plant (family) [32-390]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity), GO:0005381 (iron ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport), GO:0006826 (iron ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Odorant receptor 46a, isoform A (P81919)
Organism: Drosophila melanogaster (Fruit fly)
Function: Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity).
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Sequence: MSKGVEIFYKGQKAFLNILSLWPQIERRWRIIHQVNYVHVIVFWVLLFDLLLVLHVMANLSYMSEVVKAIFILATSAGHTTKLLSIKANNVQMEELFRRLDNEEFRPRGANEELIFAAACERSRKLRDFYGALSFAALSMILIPQFALDWSHLPLKTYNPLGENTGSPAYWLLYCYQCLALSVSCITNIGFDSLCSSLFIFLKCQLDILAVRLDKIGRLITTSGGTVEQQLKENIRYHMTIVELSKTVERLLCKPISVQIFCSVLVLTANFYAIAVLSDERLELFKYVTYQACMLIQIFILCYYAGEVTQRSLDLPHELYKTSWVDWDYRSRRIALLFMQRLHSTLRIRTLNPSLGFDLMLFSSIVNCSYSYFALLKRVNS
InterPro domains: - IPR004117: Olfactory receptor, insect (family) [12-380]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004984 (olfactory receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0051606 (detection of stimulus), GO:0042221 (response to chemical), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050877 (nervous system process), GO:0009593 (detection of chemical stimulus), GO:0007600 (sensory perception), GO:0050907 (detection of chemical stimulus involved in sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0050911 (detection of chemical stimulus involved in sensory perception of smell), GO:0007608 (sensory perception of smell)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Uncharacterized PPE family protein PPE58 (Q50702)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESLNTTLDELHENWKGSSSEWMADAALRYLDWLSKHSRQILRTARVIESLVMAYEETLLRVVPPATIANNREEVRRLIASNVAGGKHSSNRRPRGTIRAVPGRKYPSNGPLSKLDPICAIEAAPMAGAAADPQERVGPRGRRGLAGQQQCRGRPGPSLRCSHDTPRFQMNQAFHTMVNMLLTCFACQEKPR
InterPro domains: - IPR038332: PPE superfamily (homologous_superfamily) [2-132]
- IPR000030: PPE domain (domain) [1-126]
Interaction partners: - PPE family protein PPE57
- PE-PGRS family protein PE_PGRS21
- PE-PGRS family protein PE_PGRS19
- PE-PGRS family protein PE_PGRS3
- Uncharacterized protein Rv1899c
- Uncharacterized PPE family protein PPE59
- Uncharacterized PE-PGRS family protein PE_PGRS10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)