wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Interferon (Q800H1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MWTYIFVIYVILQSQSSASTCEWLGRYRIITTESLNLLKNMGGKYADLETPFPSRLYTLMDKSKVEDQVKFLVLTLDHIIHLMDAREHMNSVNWDQNTVEDFLNILHRKSSDLKECVARYAKPAHKESYEIRIKRHFRTLKKILKKKQYSAEAWEQIRRVVKSHLQRMDIIASNARVNP
InterPro domains: - IPR000471: Interferon alpha/beta/delta (family) [4-172]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [18-179]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0048583 (regulation of response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0043207 (response to external biotic stimulus), GO:1901698 (response to nitrogen compound), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0009615 (response to virus), GO:0010033 (response to organic substance), GO:0098542 (defense response to other organism), GO:0046685 (response to arsenic-containing substance), GO:0031347 (regulation of defense response), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus), GO:0042742 (defense response to bacterium), GO:0050688 (regulation of defense response to virus), GO:0043331 (response to dsRNA), GO:0014070 (response to organic cyclic compound), GO:0050691 (regulation of defense response to virus by host), GO:0043330 (response to exogenous dsRNA)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Kinesin-like protein (Q57WJ5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MQKSIQDEVRFSSSPRVLRSASRDTHKEMEELPNASSPLLMRRVASLDALPPRPSSRHPRSEGDSVPSVLNPNRQLEDLSRDTQLLNAYGGSDSMPGINKIPVKSFQQHLQGRQFHFAKHRLPQLSNVQSARSVSTPARKGRQSPRCRYNALPALSSSPPRTRRGASFARPYPNKPGTPQSSRAPPRRASARPIASPSSPLAAPLHRADSVIPAAVAEDSSADGKQSAVARTRGGRIRVVVRKRPLPPDEEGCDCVSMDPPNVKVAVRKQRVDLTEYADVNDFTFDDAFGEDKHNEHVFDSCCKELLETTLQGGSASCFAYGQTGSGKTHTMLGNSGERGLYILAAAAIFSSLEKDQEVYASLYEIYCNSLFDLLNNRSPVVVREDHNRRMHITGLTWHAVTSAEELQLLINSGADRRSTGSTTANERSSRSHAVLTIQVRDREDNRFCGTLNLVDLAGSERAADTATNDRQTRQEGAEINKSLLALKECIRALDEKKKHVPFRGSKLTEILRDSFIGNSRTVMIANISASSQNYEHTLNTLRYAFRVKGLSVVNFEPSRARNAPRPLKPVVSDMNPTQGVPQVNAGPLKTTPGRWRSVSSNAFLANRRNVSSGNALVQQRNHVTSSPLRSNNTQGANIASGAGENNFAVYVRQIAGEVVGNIIPQLRADGGRDSSLPSNSDYLQEEGSGVSFNDELIRQLEDRVVARMKLDVIRLVRDTMLRRERAISKLRSENTMLSKLNGALERRAAECAHCRGQNTRQIQQQQN
InterPro domains: - IPR027640: Kinesin-like protein (family) [219-608]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [450-461]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [233-550]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [214-550]
- IPR001752: Kinesin motor domain (domain) [234-557]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0044085 (cellular component biogenesis), GO:0031109 (microtubule polymerization or depolymerization), GO:0030030 (cell projection organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0007010 (cytoskeleton organization), GO:0065003 (protein-containing complex assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0044782 (cilium organization), GO:0046785 (microtubule polymerization), GO:0051258 (protein polymerization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0060187 (cell pole), GO:0097542 (ciliary tip), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium)
Protein: Dihydroflavonol 4-reductase (Dihydroflavonol-4-reductase-like) (A2IBG0)
Organism: Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Function: Not known
Sequence: MPTDNQMKDMKPNSIMGSSVTDGEIVCVTGGSGFIGSWLIKLLLERGYVVRATVRDPGNSKKVKHLLELPKAETHLTLWKADLAEEGSFDDAIQACTGVFHVATPMDFESEDPENEVIKPTINGVLSIMKACAKAKTVRRLVFTSSAGTIDVAEQQKPCYDETCWSDLEFIQAKKMTGWMYFVSKTMAEQAAWKFAKENNIDFVSIIPPLVVGPFIMQSMPPSLITALSPITGNEAHYSIIKQGQFIHLDDLCRAHIFLFENPKAEGRHICASHHATIIDLAKMLSEKYPEYNVPTKFKDVDENLKSVEFSSKKLLDLGFEFKYSLEDMFVGAVETCREKGLLPLSNEKKIKNID
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [20-338]
- IPR050425: NAD(P)-dependent dehydratase-like (family) [25-329]
- IPR001509: NAD-dependent epimerase/dehydratase (domain) [26-266]
Interaction partners: - Leucoanthocyanidin dioxygenase-like
- Leucoanthocyanidin dioxygenase-like
- Leucoanthocyanidin dioxygenase-like
- Leucoanthocyanidin reductase-like
- Leucoanthocyanidin reductase-like
- Leucoanthocyanidin reductase-like
- Flavonol synthase/flavanone 3-hydroxylase-like
- Flavonol synthase/flavanone 3-hydroxylase-like
- Flavonol synthase/flavanone 3-hydroxylase-like
- Flavonol synthase/flavanone 3-hydroxylase-like
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0043473 (pigmentation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Q498E0)
Organism: Rattus norvegicus (Rat)
Function: Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity.
Subcellular location: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12930873}.
Sequence: MSLRFGATCLLSFSFLLLITSSDGRTGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPRDEDFSPDGGYIPRILFLDPSGKVRPEIINESGNPSYKYFYVSAEQVVQGMKEAQVRLTGDAFREKHFQDEL
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [33-152]
- IPR013766: Thioredoxin domain (domain) [4-151]
- IPR037462: ERp19 (family) [34-150]
- IPR051099: Anterior Gradient and Thioredoxin Domain (family) [7-164]
- IPR017937: Thioredoxin, conserved site (conserved_site) [56-74]
Interaction partners: - Glutathione hydrolase 6
- Glutathione hydrolase 7
- Glutathione hydrolase 5 proenzyme
- Glutathione synthetase
- Putative glutathione-specific gamma-glutamylcyclotransferase 2
- Glutathione-specific gamma-glutamylcyclotransferase 1
- Glutathione S-transferase A6
- Glutathione S-transferase alpha-3
- Glutathione S-transferase Mu 4
- Glutathione S-transferase theta-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0015035 (protein-disulfide reductase activity), GO:0016671 (oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor), GO:0015036 (disulfide oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0032355 (response to estradiol), GO:0033993 (response to lipid), GO:0014070 (response to organic cyclic compound)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005788 (endoplasmic reticulum lumen), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen)
Protein: KIF-binding protein (KIF1-binding protein) (Q6ZPU9)
Organism: Mus musculus (Mouse)
Function: Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96EK5}.
Sequence: MANAPGPEIREKFQAALALSRVELHKNPEKEPYKSKYGARALLEEVRALLGPAPEDEDEPAADDGPGDQALGAGEPREAEGPGAQRALRLAVVEFHLGVNHIDTEELSAGEEHLVRCLSLLRPYRLSLGCVSLYIQAQNNLGILWSEREEIETARTYLESSEALYSQYMKEIGSPPLDPTEHFLPEEEKLTEQERSKRFEKVYTHNLYYLAQVYQHMEMFEKAAHYCHSTLKRQLEHNAYHPMEWAINAATLSQFYINKLCFMEARHCLSAANVIFGQTGKIPATEDTPEVEGDVPELYHQRKGEIARCWIKYCLTLMQNAQLSMQDNIGELDLDKQSELRALRKKELDEEESVRKRAVQFGTGELCDAISAVEEKVRYLRPLDFEEARELFLLGQHYVCEAKEFFQIDGYVTDHIEVVQDHSALFKVLSFFEADMERRCKMHKRRIAMLEPLTVDLNPQYYLLVSRQIQFEIAHAYYDMMDLKVAIADKLRDPDSHIVKKINSLNKSALKYYQLFLDSLRDPNKVFPEHIGEDVLRPAMLAKFRVARLYGKIITADPKKELENLATSLEHYKFIVDYCETHPEAAQEIEVELELSKEMVSLLPTKMERFRAKMALT
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [74-280]
- IPR022083: KIF-1 binding protein (family) [243-609]
Interaction partners: - U6 snRNA-associated Sm-like protein LSm1
- CCR4-NOT transcription complex subunit 1
- U6 snRNA-associated Sm-like protein LSm7
- CCR4-NOT transcription complex subunit 4
- Protein LSM14 homolog A
- Protein LSM14 homolog B
- CCR4-NOT transcription complex subunit 3
- m7GpppN-mRNA hydrolase
- Kinesin-like protein KIF1B
- Protein PAT1 homolog 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0019894 (kinesin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0046907 (intracellular transport), GO:0051649 (establishment of localization in cell), GO:0006810 (transport), GO:0006839 (mitochondrial transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: PSI P700 apoprotein A1 (Q2F6M2)
Organism: Oryza sativa (Rice)
Function: Not known
Sequence: MMIRSPEPEVKIVVDRDPVKTSFEEWARPGHFSRTIAKGPDTTTWIWNL
InterPro domains: - IPR036408: Photosystem I PsaA/PsaB superfamily (homologous_superfamily) [1-49]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002683 (negative regulation of immune system process), GO:0048585 (negative regulation of response to stimulus), GO:0050777 (negative regulation of immune response), GO:0002698 (negative regulation of immune effector process), GO:0050776 (regulation of immune response), GO:0080134 (regulation of response to stress), GO:0031348 (negative regulation of defense response), GO:0031347 (regulation of defense response), GO:0050728 (negative regulation of inflammatory response), GO:0045824 (negative regulation of innate immune response), GO:0045916 (negative regulation of complement activation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog (dNDUFAF6) (Protein severe impairment of CI with lengthened youth) (Q9VYS5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (Complex I) at early stages. Interacts with cytosolic Hsp90 to chaperone the Complex I subunit ND-42 in the cytoplasm.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:23509070}. Cytoplasm, cytosol {ECO:0000269|PubMed:23509070}.
Sequence: MRRLVRNWNCRLLFNAKSGQEIVSHAGIHQEAKTNAIPREKKVIEADKNGYGAKHCMSLVEKYDYENYLCTLLLPRELRRAAFALRAFNVEVSRSVSGHQIEPQIAKMRLKFWHDSIDKCFEPDSQRSYVEDQPVLRELKHTVGSRKLNKVYLRRLVTARERPPTHAFESIRELEEYTEQTFSSLLLLLLEVGGVRDLNADHAASHLGKAQGIATLLRSIPLAGRQQAPCIPLEVLVLHGVSQERIIRSKSDDKGVEDCIFDVASAANTHLKLARQLHDKVPPQVRKIFLSAVATDAYLERLRRANFLLTHKSCVGRDTLLPARLFWKSLLNRF
InterPro domains: - IPR008949: Isoprenoid synthase domain superfamily (homologous_superfamily) [51-332]
- IPR002060: Squalene/phytoene synthase (family) [61-309]
Interaction partners: - GM10285p
- NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial
- Arginine-hydroxylase NDUFAF5, mitochondrial
- Hydroxymethylglutaryl-CoA synthase
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- Mitochondrial ribonuclease P catalytic subunit
- RE26969p)
- Fatty acid hydroxylase domain-containing protein
- G1/S-specific cyclin-E
- rRNA biogenesis protein RRP5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Alpha-catulin (Q8T3U1)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MAASSMSSLTSSYHTTAMPSSNSVVPPFDARNLEIKTKSIEQTLIPLVTQITTLVNYKESYMASGKPKSERAMRAALKIGSAVEAAIERFVCVGETIADENADIQPEMYDACTEARLAGASMANLSCACNDDPNSVVDKAVLVRASRQLLSSVTRVLLLADRVLVKQVLRAEDKIAFSLSRLESTRSFNDFVKVFAVFGGEMVELAHRSGDRQHDLKSEKRKAQMSIARTSLERLTMLLLTASKTYLRHPDCDSALQCRDGVFYQMKLSLELIAICVCDGILTTEKSRYIQDEPDMPIDIALQLTANAAIKQLTEMLEMIRMTVRVGAGVRERIVSALDALCQLTQDFTDSAYTPHHQREQILDFLEECRFEMTNLIQPDENEQLAASGLEVTVERLNRRLKDLSKQLQIVAMEQISEVLRANEDQVLLSSMKACAVSGDIDGVEKYMHKFREHADHMQEVCRLLHHISITDALHVHTGHVERNMRALAPLTILAGRTLCVHPSSRIARENLEVFCDTWGQAVNDLSRVAKESDVAANGRVAAEKQAYMSLPRPGVSKSSCRRSVPKHDAASSSSSNELLPNGGRHPKQVGIAPTRVVSQTGDEASSDEEQVDKQEIEAFQYRISLIIDDLQSDVEGGTHGR
InterPro domains: - IPR006077: Vinculin/alpha-catenin (family) [34-527]
- IPR001033: Alpha-catenin (family) [27-419]
- IPR030045: Alpha-catulin 1 (family) [17-576]
- IPR036723: Alpha-catenin/vinculin-like superfamily (homologous_superfamily) [77-532]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0040012 (regulation of locomotion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0055120 (striated muscle dense body), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0005886 (plasma membrane), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Slr1944 protein (P74506)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Not known
Sequence: MIDFKRLLGIALTSSLLVLASPSVIKGAETITFSIMPLGQFDISVKSLTDFAETGTIDPDFKFYTQHLKPEELEKLRGLLNHSFKFNSVEAFRFFNTTFGKEIAQQLSYIIAAPTDQSQPFLEGAIVTAAQNPDGFKIIDVINAYGGSDLVLNLDTFKNTIDQADTLYQATDRIFTWLGKQEIPSNPVPPNLKPLALAEPGPQKWTTQNLTIPRPNGQPVNVFVYLPQGNSSPAPLVVIAPGLNSNFQAFTYIADHLASYGFTIAGIDFPESDAARMQDSLQGLDAFPDPNAWLEQPKDVTLVLDTLAQKAATDPAWQGKFDINNVGILGHSLGGYTAIASGGATLEWPELLQQCEQLNKPNQINLNPALLWQCQGVGSAPPASNLRESRIKAVLAINPVTNPIFGPDGMKNLAVPTLIVAGSKDIFAPPVPEQIIPFSLIEGVNKYLLLVQNGTHLSFLEDTDNLPEKIVGPGQDLAYTYMKSLGLAFFDLYLQQDSSFKPYLTDSVVQQMSQEPLPLQLVPSLTPAQLQQAMDINN
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [189-516]
- IPR010802: Domain of unknown function DUF1400 (domain) [28-153]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0030258 (lipid modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC 5.3.1.16) (5-proFAR isomerase) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) (Q10184)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MEKSQHTLFRPCIDIHQGQVKQIVGGTLGNDADVKTNYVSLKPSSYYAELYKLNHLEGAHVIMLGPNCEEAAKTALHTWPGALQIGGGINISNAQNWLQEGASKVIVTSWLFPDAQFDLDRLKAISSKIGKDRLVVDVSCRRKDNRWFAAINKWQVMTAFELNEENLDLLSQYCSEFLIHAADVEGLCKGIDEDLVIKLGEWVKIPTTYAGGGRSIEDLDLVDKLSKGKVDLTIGSALDIFGGVLEFTRVVAWNRRFTPLPLQD
InterPro domains: - IPR011060: Ribulose-phosphate binding barrel (homologous_superfamily) [9-245]
- IPR044524: Histidine biosynthesis, HisA-like (family) [8-256]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [7-257]
- IPR006062: Histidine biosynthesis protein (family) [11-238]
- IPR011858: His6/HISN3 (family) [7-255]
Interaction partners: - Imidazole glycerol phosphate synthase hisHF
- Histidine biosynthesis bifunctional protein his7
- Histidinol dehydrogenase
- Imidazoleglycerol-phosphate dehydratase
- ATP phosphoribosyltransferase
- Histidinol-phosphate aminotransferase
- Multifunctional tryptophan biosynthesis protein
- ATP-dependent helicase rhp16
- Tryptophan synthase
- Anthranilate phosphoribosyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0016861 (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006547 (histidine metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0000105 (histidine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)