Protein: BEL1-like homeodomain protein 9 (BEL1-like protein 9) (Protein BELLRINGER) (Protein LARSON) (Protein PENNYWISE) (Protein REPLUMLESS) (Protein VAAMANA) (Q9LZM8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Transcription factor that is involved in the preservation of the spiral phyllotactic arrangement leading to a regular pattern of organ initiation. Required for maintenance of stem cell fate in the shoot apical meristem, and is essential for specifying floral primordia and establishing early internode patterning events during inflorescence development. Acts as transcription repressor of AG expression in floral and inflorescence meristems. Is also responsive of the nuclear import of SHOOT MERISTEMLESS (STM). In the fruit, plays a central role in patterning by negatively regulating SHP expression in order to prevent replum cells from adopting a valve margin cell fate.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MADAYEPYHVLQQSRRDKLRIPSLDSHFHFHPPPPPSSGGGGGVFPLADSDFLAAGGFHSNNNNNHISNPSYSNFMGFLGGPSSSSSTAVAVAGDHSFNAGLSSGDVLVFKPEPLSLSLSSHPRLAYDLVVPGVVNSGFCRSAGEANAAAVTIASRSSGPLGPFTGYASILKGSRFLKPAQMLLDEFCNVGRGIYTDKVIDDDDSSLLFDPTVENLCGVSDGGGGDNGKKKSKLISMLDEVYKRYKQYYEQLQAVMGSFECVAGLGHAAPYANLALKALSKHFKCLKNAITDQLQFSHNNKIQQQQQCGHPMNSENKTDSLRFGGSDSSRGLCSAGQRHGFPDHHAPVWRPHRGLPERAVTVLRAWLFDHFLHPYPTDTDKLMLAKQTGLSRNQVSNWFINARVRVWKPMVEEIHMLETRQSQRSSSSSWRDERTSTTVFPDNSNNNPSSSSAQQRPNNSSPPRRARNDDVHGTNNNNSYVNSGSGGGSAVGFSYGIGSSNVPVMNSSTNGGVSLTLGLHHQIGLPEPFPMTTAQRFGLDGGSGDGGGGYEGQNRQFGRDFIGGSNHQFLHDFVG
InterPro domains: - IPR001356: Homeodomain (domain) [349-413]
- IPR006563: POX domain (domain) [165-292]
- IPR008422: KN homeodomain (domain) [366-405]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [351-416]
- IPR050224: Three Amino acid Loop Extension (TALE) homeobox (family) [86-449]
Interaction partners: - Agamous-like MADS-box protein AGL8
- Homeobox protein knotted-1-like 1
- Protein KNATM
- Homeobox protein SHOOT MERISTEMLESS
- Homeobox protein knotted-1-like 6
- Agamous-like MADS-box protein AGL5
- Agamous-like MADS-box protein AGL1
- Axial regulator YABBY 1
- Axial regulator YABBY 3
- Zinc finger protein JAGGED
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0042445 (hormone metabolic process), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0009791 (post-embryonic development), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0006950 (response to stress), GO:0044238 (primary metabolic process), GO:0009266 (response to temperature stimulus), GO:0048316 (seed development), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0048608 (reproductive structure development), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0042446 (hormone biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0006139 (nucleobase-containing compound metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0090066 (regulation of anatomical structure size), GO:0009059 (macromolecule biosynthetic process), GO:0061458 (reproductive system development), GO:0097305 (response to alcohol), GO:1901362 (organic cyclic compound biosynthetic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010468 (regulation of gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0033993 (response to lipid), GO:0018130 (heterocycle biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0009737 (response to abscisic acid), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0010154 (fruit development), GO:0016070 (RNA metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0016071 (mRNA metabolic process), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0009299 (mRNA transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)