Protein: Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] (P01031)
Organism: Homo sapiens (Human)
Function: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Subcellular location: Secreted.
Sequence: MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC
InterPro domains: - IPR000020: Anaphylatoxin/fibulin (domain) [682-750]
- IPR018933: Netrin module, non-TIMP type (domain) [1549-1662]
- IPR011626: Alpha-macroglobulin-like, TED domain (domain) [978-1300]
- IPR018081: Anaphylatoxin, complement system (homologous_superfamily) [679-750]
- IPR050473: Alpha-2-macroglobulin/Complement system (family) [6-1537]
- IPR009048: Alpha-macroglobulin, receptor-binding (domain) [1419-1510]
- IPR008993: Tissue inhibitor of metalloproteinases-like, OB-fold (homologous_superfamily) [1526-1676]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [351-1491]
- IPR001840: Anaphylatoxin, complement system domain (domain) [694-734]
- IPR002890: Macroglobulin domain (domain) [126-219]
- IPR041555: Macroglobulin domain MG3 (domain) [221-304]
- IPR041425: Complement C3/4/5, macroglobulin domain MG1 (domain) [20-120]
- IPR001599: Alpha-2-macroglobulin (domain) [772-859]
- IPR011625: Alpha-2-macroglobulin, bait region domain (domain) [465-612]
- IPR008930: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (homologous_superfamily) [992-1304]
- IPR048843: Complement component 5, CUB domain (domain) [1311-1366]
- IPR036595: Alpha-macroglobulin, receptor-binding domain superfamily (homologous_superfamily) [1373-1527]
- IPR001134: Netrin domain (domain) [1532-1676]
- IPR040839: Macroglobulin domain MG4 (domain) [355-457]
Interaction partners: - Complement component C8 alpha chain
- C5a anaphylatoxin chemotactic receptor 1
- Complement component C6
- Complement component C9
- Complement component C7
- Complement component C8 beta chain
- Complement component C8 gamma chain
- C5a anaphylatoxin chemotactic receptor 2
- Complement C3
- Prothrombin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0030246 (carbohydrate binding), GO:0005515 (protein binding), GO:0001848 (complement binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0002252 (immune effector process), GO:0050794 (regulation of cellular process), GO:0002253 (activation of immune response), GO:0048584 (positive regulation of response to stimulus), GO:0051050 (positive regulation of transport), GO:0006955 (immune response), GO:0032879 (regulation of localization), GO:0002684 (positive regulation of immune system process), GO:0050778 (positive regulation of immune response), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0050776 (regulation of immune response), GO:0006956 (complement activation), GO:0006959 (humoral immune response), GO:0050766 (positive regulation of phagocytosis), GO:0050764 (regulation of phagocytosis), GO:2000427 (positive regulation of apoptotic cell clearance), GO:2000425 (regulation of apoptotic cell clearance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0072562 (blood microparticle), GO:0005615 (extracellular space), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0060205 (cytoplasmic vesicle lumen), GO:0005788 (endoplasmic reticulum lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:1905286 (serine-type peptidase complex), GO:0034774 (secretory granule lumen), GO:0065010 (extracellular membrane-bounded organelle), GO:0042582 (azurophil granule), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0031982 (vesicle), GO:1905369 (endopeptidase complex), GO:0005764 (lysosome), GO:0035578 (azurophil granule lumen), GO:1903561 (extracellular vesicle), GO:0097708 (intracellular vesicle), GO:1905370 (serine-type endopeptidase complex), GO:0005766 (primary lysosome)