Protein: Leucine-rich repeat protein (LRRP) (Q38C48)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MRRVFRKSLSGALSYRWCWSPQPGPSYPTPEALVETIRRQGPKESVWNLDFSFLPKRPSTQGEDVPDDVLRSCSVALSESALTVKRLSLTINSPEAVEVAIRFLRGAQLPALRTLDLTLHNVAFVQNERMLATLLQSAAGVAGRLAELRVAMITHDIRSGLQWGRQQRVPTALATLLSASALESLSLEHLVMSSTSDEETLVLNAAILNSCRGLRQLSLSGSASLLRCDSFLHDTLMGMPRLEVLDLSGICLNDVQIQKLLVSLRVSIGGWHNLQQLNLAGCGLSTWALGLMQNDLGDPHPLPSNSSFGLKVLNLSSNGIDDEGAFVLATVCMRCRWIEEIYLRHNRITEKGAAAICSAVREGTELRVLSFHSNLLKDEGLLEVLRHFEGWPKLQRFDVTRCRLTVRCLPSLCIALLSSKALQELVLDRNDLRLLDTSDVTGTTGGGVHLFAFDSMRSGIGSADIKALTSFEVDRRDALEGRQRHKGTGPANEEKKFNSTFIGAAPFERLGSALASCAELRSFSASGCSLTDTAFLSLTAALQRCRLTHLNLSSNPLFTHVEGIEALGRLLHCASEALEVLDVSCTGLGNVGIAVLADGLSDSVSEMVGEPPLRSLGALRELHVSHCRIGDDGFGALADVVPFMCSLERLFLDGNQVTSVPVVVSLLGKLSTLPSLVFVGLHGTLSPRSGAEVAVCSEYSLLRRKGITVHV
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [68-693]
- IPR006553: Leucine-rich repeat, cysteine-containing subtype (repeat) [517-640]
- IPR001611: Leucine-rich repeat (repeat) [310-667]
- IPR027038: Ran GTPase-activating protein (family) [416-683]
Interaction partners: - SUMO-conjugating enzyme UBC9
- GTP-binding nuclear protein
- Small ubiquitin protein, putative
- Ran-binding protein 1, putative
- RanBD1 domain-containing protein
- Nuclear pore complex protein
- SUMO1/Ulp2, putative
- Nucleoporin
- Poly
- Nuclear pore protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0051651 (maintenance of location in cell), GO:0019222 (regulation of metabolic process), GO:0051235 (maintenance of location), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0048523 (negative regulation of cellular process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0009894 (regulation of catabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0032507 (maintenance of protein location in cell), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0045184 (establishment of protein localization), GO:0045185 (maintenance of protein location), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0010507 (negative regulation of autophagy), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0015031 (protein transport), GO:0031330 (negative regulation of cellular catabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0030162 (regulation of proteolysis), GO:2000059 (negative regulation of ubiquitin-dependent protein catabolic process), GO:1901799 (negative regulation of proteasomal protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0045861 (negative regulation of proteolysis), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0032435 (negative regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:1903051 (negative regulation of proteolysis involved in protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)