Protein: Male gametocyte surface protein P230p (O96175)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Plays an essential role in male gamete fertility (By similarity). Required for the binding to erythrocytes and thus, for the formation of exflagellation centers (By similarity).
Subcellular location: Cell surface {ECO:0000269|PubMed:12106866}. Cell membrane {ECO:0000269|PubMed:12106866, ECO:0000269|PubMed:30297725}; Peripheral membrane protein {ECO:0000305}. Note=Present on the surface of male gametocytes. {ECO:0000269|PubMed:12106866, ECO:0000269|PubMed:30297725}.
Sequence: MFIYLFIYLFFKMDKKRTFYYLFFFFTFLVYVLYFDNIKSVLRSSTKKKKKKKICKSTFYVHEESEEIKSWLRNSNERDKGKKFFIFERLIKERKYICVNKYKRNNKLKWIYKNTYEKTKNICDDYNILFKCIKGIIYDKNKETFFETFFENFWDNIFYMNKYIFNIYYYMFDYTKKVKKKIEGIKENMNIRHNNNYNNIFYVHKFFLFNDDEEKKKRNDDIKINIKLHNNTRKLSVSEENVELKPYIKQGERNETVVNLYEYFTGGVKRSNNNNEIVVTSTEQFHRIVIICFKPTVKHSHIITSPHDALNHIVEENDKIKLSEEIYSIPFYPIYGNLGLKNVITTGIVEFMIPYFSRTQMNFTVTCANGEMNDLYKFEDLIKIRIRIPRNTKKILGLSTNEKDKTVFERIVDNTSNEYRFKSYNNKIVGIKLENSILDPPGCFKTVYEDDKILQLEVFLQYVKCINLDRDNYKIRFFFLPEDFGDEEIEFSCKFTYKKKTSKIIFGLGETSVDKDIFYLEDEHVKLNINQDISGDEPYYSHLNYNGIPYNICNFQYKSEYDSQVCERTIHEFSLFIYNCDTLVGTQIQTTEPITSVKYLNSTYPINKFSDITLLSKDIDIEGLEEAFRNSKFFLTSYINHGPFPLIIECVISNSNKDYQNVYILLHLRTSIKNRSVSFCDFEKVQGYNYLNNYIDGKICNINITSNSVFGFRCPSNSIKEPKDCFSQVYIDKKVYKLNDKLSNKLILYSMKQENLAIAGFNNYISNSFSFECYCIDKNQTYSSYERTSGEDIFNHIVKRIHVHYKNYDELYDYNIHDKITYEPIMKNPPITYLCDFLNKKQILQPLNNKTKNYICTIWYPKPLNYIALNCPTNRRDEQNDQTISEVYNSLQKDLLKPTGIEQQIDQKKKELNLLFNKRNIYSNLYHLPKNAPKRTINKNGLNIVNIDEIIPGILIKDVINMKLEDVIKPDLLTPTSFLHKTYNTNKSYLFSTRNKSTSVFNTPSIYTPLTHTSFSISPKSVPLTKSRIEETHSSSNTYEQYIGKRNSIENGFFIFQLPPYLKKNQTIEFACINDSTIKNKNVGNNGIMTIHLKSFGNPIEGCYFYKNSAKYNYLKKSIKIDDLKKEECTIRSDGEIEFVGIMCPYENNLYLTPSSCFLKTYDNTDNLVELLDINENFEYYSNDKGISYLKIPQEFLNHVHLFCYCNVDKDSVSDTNVLVKKENKISLELNYSNKGFNIIKTIDYQYEADILIGYSYYFKRVTPIYRKKHICDFTTEDNSLEPESEDKMIYSCYLSLENNLNFIEVKCPKNKKSSNSEWLFKYGTFDKSSEIMEDDENIKKYEHMKYMPEDKDEIIYLFKKQKLEDILPGVIIFDKNRYFFEKGNFSFVTPLIVKEDVTIKLLCDNSETKIDDKIGKKGIILIKIPQHITDKKFYGCDFSGDSNKKSSFYYTSVYDLKTQNQYCEVKLKENIIISLNCPNGNINPNNCFNNVFLKTNMNEQIHEKIQNIFDQVKVINTKSHVLLNSSSTFLIISKITKKELNFFCTCHHNETKNVGTIYIKNEDIINFSKAYNKESSILQYIDVTPYYLKDTYICDFTQNHYSISFDTSVNVQNVLERYLKILSDLYNTHEEFTYFSIHLKLKKEIMKKKYIDYLKKKINEYKEKETSDKIKRVTLSTNDNINTILVYRCNIDLGSFDKFKIKCPSKLNEEEVENNKLYPNLIYSSNLGLDETDMLNGLTKLLYGSVLINKTEKNVSFFEKGELELIISPYTDSSKNIIFSCENVPRNLSKGIIGSASIFIKKNDNKILGCDFIDTPSTLSSASTLESSYGSHASSPLSSSHHVLHNDNQGHDVHMINHIDISNKKNSFEFEIELIEGKNTYCNIEAIENDIVGFSCPYNFLTTPSDCFESIQIEGVDKELETHKLEKLLKGVKILNNDIYKYNFTPSYIILPKKIKKSLKIFCRCNSVKLIKTGIIQINIVGDDLNNWFKKEITHNIFAYQKMDYFYDFSKGPTNISSENVLGISTMSLMSSNKKVSRKKNHKEENRTQQNVYKEIENDHKNINENVNKYDNLPVTLLSSDEGDGYQADEDIGGEDDAEDVDGEGDDEDDNILNPLRTKQVYDIIVAASEFSKIEVVCPLRNSSQFRQSKISPENFFEYVYVLEDKNDDKRKRSIEENEKLVKAILEGKKNIDGHIINIEDINNKKSSKNASVEYDDMGNKIFISIISEKPKAVIGDNISSSRSSVHISNNIMNSSFQSNIHPDPITSDTTTSEYEQYNSYFKDILVIKNINEVISFANIKIDINEQTYSSSLHIPPLILKDAEFLISCDNSLTLNENTRGKTATVKIKVKSNFLKIYGCDFVGEFSTHFLFSKKWDDIPKNYICKINIQDDMLIGLACPSFTKLHPPDCFENIIVNQNVYKKNIIMETKNMFFYKQNDKPILSFVHVKKILVETFLCKCYQVTKADYKEVTIQILYEPYVMGTPKYTLEKSIIQYRYANLKPPLHI
InterPro domains: - IPR051444: Parasitic Reproductive and Invasion Surface Protein (family) [1593-2486]
- IPR010884: 6-Cysteine (6-Cys) domain (domain) [394-2481]
- IPR038160: 6-Cysteine (6-Cys) domain superfamily (homologous_superfamily) [397-2486]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0051701 (biological process involved in interaction with host), GO:0044000 (movement in host), GO:0044409 (entry into host)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0020003 (symbiont-containing vacuole), GO:0033655 (host cell cytoplasm part), GO:0030430 (host cell cytoplasm)