Protein: C-X-C motif chemokine 6 (Granulocyte chemotactic protein 2) (GCP-2) (Small-inducible cytokine B6) (P80221)
Organism: Bos taurus (Bovine)
Function: Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity).
Subcellular location: Secreted.
Sequence: MRLLSSRAARVSGPSGSLCALLALLLLTPPGPLASAGPVAAVVRELRCVCLTTTPGIHPKTVSDLQVIAAGPQCSKVEVIATLKNGREVCLDPEAPLIKKIVQKILDSGKNN
InterPro domains: - IPR033899: CXC Chemokine domain (domain) [45-106]
- IPR036048: Chemokine interleukin-8-like superfamily (homologous_superfamily) [42-107]
- IPR001089: CXC chemokine (family) [47-102]
- IPR018048: CXC chemokine, conserved site (conserved_site) [48-92]
- IPR001811: Chemokine interleukin-8-like domain (domain) [45-105]
- IPR039809: Chemokine beta/gamma/delta (family) [19-108]
Interaction partners: - C-X-C chemokine receptor type 2
- C-X-C chemokine receptor type 2
- C-X-C motif chemokine 14
- Growth-regulated protein homolog gamma
- Interleukin-8
- C-X-C chemokine receptor type 4
- C-C motif chemokine 2
- C-X-C motif chemokine 11
- C-C motif chemokine 5
- Stromal cell-derived factor 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009605 (response to external stimulus), GO:0007267 (cell-cell signaling), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0097529 (myeloid leukocyte migration), GO:0035556 (intracellular signal transduction), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0006952 (defense response), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0030036 (actin cytoskeleton organization), GO:0010033 (response to organic substance), GO:0016477 (cell migration), GO:0071621 (granulocyte chemotaxis), GO:0060326 (cell chemotaxis), GO:0034097 (response to cytokine), GO:0097530 (granulocyte migration), GO:0006954 (inflammatory response), GO:0000165 (MAPK cascade), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0007010 (cytoskeleton organization), GO:0070371 (ERK1 and ERK2 cascade), GO:0002544 (chronic inflammatory response), GO:0070670 (response to interleukin-4), GO:0002761 (regulation of myeloid leukocyte differentiation), GO:0016064 (immunoglobulin mediated immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)