Protein: Integrin beta-7 (Integrin beta-P) (M290 IEL antigen) (P26011)
Organism: Mus musculus (Mouse)
Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E-cadherin.
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
Sequence: MVDSSTVLIFLLVLGGGQSELDTKITSSGEAAEWEDPDLSLQGSCQPVPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPAQELEEPRGRQEVLQDKPLSQGDRGEGATQLAPQRIRVTLRPGEPQKFRVRFLRAAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLHHPCPSRLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAVGELSEDSSNVVQLIMDAYDSLSSTVTLEHSPLPPGVSISFESHCKGPEKTEGEAGDRGQCNDVRVNQTVDFWVTLQATHCLPEAHVLRLWALGFSEELTVELHTVCDCNCGDAQPHAPYCSDGQGDLQCGICSCAPGRLGQLCECSEADLSSPDLESGCRAPNGTGPLCSGKGRCQCGRCSCSGQSSGRLCECDDASCERHEGILCGGFGHCQCGVCHCHANHTGRACECSKSVDSCVSPEGGLCSGHGYCKCNRCQCLDGYYGALCDQCLGCKSPCEQYRDCAECGAFGTGPLAANCSVVCADVNVTLTLAPNLDDGWCKERTIDNQLFFFLVEHAASGIVLRVRPQEKGVDHTRAIILGCTGGIVAVGLGLVLAYRLSVEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAITTTVNPRFQGTNGRSPSLSLTREAD
InterPro domains: - IPR014836: Integrin beta subunit, cytoplasmic domain (domain) [746-792]
- IPR016201: PSI domain (domain) [44-92]
- IPR033760: Integrin beta N-terminal (domain) [44-92]
- IPR013111: Epidermal growth factor-like domain, extracellular (domain) [605-635]
- IPR012896: Integrin beta subunit, tail (domain) [645-721]
- IPR057243: Integrins beta, I-EGF domain, conserved site (conserved_site) [613-626]
- IPR002369: Integrin beta subunit, VWA domain (domain) [50-476]
- IPR040622: Integrin beta, epidermal growth factor-like domain 1 (domain) [480-506]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [391-480]
- IPR036349: Integrin beta tail domain superfamily (homologous_superfamily) [644-708]
- IPR015812: Integrin beta subunit (family) [6-794]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [147-393]
Interaction partners: - Integrin alpha-E
- Integrin alpha-4
- Fibronectin
- Vascular cell adhesion protein 1
- Integrin alpha-5
- Mucosal addressin cell adhesion molecule 1
- Proto-oncogene tyrosine-protein kinase Src
- Focal adhesion kinase 1
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044085 (cellular component biogenesis), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0071559 (response to transforming growth factor beta), GO:0007229 (integrin-mediated signaling pathway), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0034330 (cell junction organization), GO:0071363 (cellular response to growth factor stimulus), GO:0022607 (cellular component assembly), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0150115 (cell-substrate junction organization), GO:0034329 (cell junction assembly), GO:0007179 (transforming growth factor beta receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0043235 (receptor complex), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0005576 (extracellular region), GO:0098636 (protein complex involved in cell adhesion), GO:0098797 (plasma membrane protein complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0070062 (extracellular exosome), GO:0008305 (integrin complex), GO:0005886 (plasma membrane), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)