wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Sidoreflexin (F1R5W5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. May also transport other amino acids including alanine and cysteine
Subcellular location: Mitochondrion membrane; Multi- pass membrane protein
Sequence: MAATISTSINIKEPRWDQGTFVGRAKHFFTVTDPRNILLSNKQLEKAHQIIQDYKKGVVAADLTEDELWRAKYVFDSAFHPDTGEKMLLIGRMSAQVPMNMTITGCMMTFYRTTPAVLFWQWINQSFNAIVNYTNRSGDAPITVNQLGTAYVSATTGAVATALGLNALAKHVSPLIGRFVPFAAVAAANCINIPLMRQRELKHGIPVTDENDNRLGESSKAAQQAITQVVVSRILMASPGMAIPPFLMNSLEKKAFLKRFPWMSAPIQVGLVGFCLVFATPLCCALFPQKSSMAVSRLEPELQEKIRASHPGVETVYFNKGL
InterPro domains: - IPR004686: Tricarboxylate/iron carrier (family) [9-322]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015175 (neutral L-amino acid transmembrane transporter activity), GO:0022889 (serine transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0044237 (cellular metabolic process), GO:0055085 (transmembrane transport), GO:0044281 (small molecule metabolic process), GO:1990542 (mitochondrial transmembrane transport), GO:1903825 (organic acid transmembrane transport), GO:0006730 (one-carbon metabolic process), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0003333 (amino acid transmembrane transport), GO:0006865 (amino acid transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0015804 (neutral amino acid transport), GO:0046942 (carboxylic acid transport), GO:0032329 (serine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Small muscular protein (Q6GMK5)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair
Sequence: MSKQPSSNVKALQANLNIPMGALRPGAGHPVKRREDTVETEEVSPVTPEEKKPLPGAVKLPGPAVNLSELQNVKSELRWVTKD
InterPro domains: - IPR029268: Small muscular protein Chisel (family) [1-82]
Interaction partners: - Thrombospondin-type laminin G domain and EAR repeat-containing protein
- Ribose-phosphate pyrophosphokinase 1
- RNA-binding protein 24
- Cysteine and glycine-rich protein 1
- G protein-signaling modulator 2
- Ribose-phosphate pyrophosphokinase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding), GO:0003785 (actin monomer binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009790 (embryo development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030017 (sarcomere), GO:0031674 (I band), GO:0030018 (Z disc), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle)
Protein: Nicastrin (Q5XLR3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass type I membrane protein
Sequence: MENLISINCVQLLITALFYTCISCSSVEQKIYVELNKTAPCVRLLNATHQIGCQSSISGDTGVVHVLESESDLDWILSAGPHPPYMVIMETAFFNRSVMLSMKNSSRVAGVAVIISKAGLAEHFSPHTTCPNQNTGVYSAGSEFANCNGTVWNPLGNGLSYEDFTFPVFALKDENQTQVIRKCYEDHNLRVNGSAPQYPLCAMQLFSHMHAVTDTVTCMRRTDLQNKFSINPEILCDPLSDYNVWTSIRPLNNSARGHAENESVVIAAVRLDGRSFFWEEAPAAEGTVSAIVTLLAAIHALYPVIQEAPPLRNIFFTFFQGEAFDYIGSSRMVFDMERNQFVMDLDNVHSMLEIGQVGLRGGRDVWIHSDPVSRRNSSMEKQVSEMIKDVNSSAAGLNINLQEPSVSQPLPPSSFQRFLRVRPIPGLVLTDHEKAFNNRYYESMYDDAENLNVSYPPNLTPDEQLVYPTDAAKSLAEVATLVARSLYTQAGGEQNNLSNITADATMVSQLLYGFLVQKNNSWFRSLLPPEITKKGGSSILSSGPPQFYIGLGPRLQSPVHSVTLFVQYILANLTGNVTNLTESQCQNPKELSGENKDLYSYFWVSGPSSGNSSADPLCVRASVRLSKAVSPAFELLQYGSSDYSTWTESRWKSIRARIFLVASRELEMLTLGVGVAVLLLSLLVTYFISSKAELLFSSARETPTTTY
InterPro domains: - IPR008710: Nicastrin (family) [10-696]
- IPR041084: Nicastrin, small lobe (domain) [40-211]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:0012505 (endomembrane system), GO:0098797 (plasma membrane protein complex), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0070765 (gamma-secretase complex), GO:0055037 (recycling endosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005770 (late endosome), GO:0097708 (intracellular vesicle)
Protein: Non-histone chromosomal protein HMG-like (A0A0R4IBX9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation
Subcellular location: Nucleus
Sequence: MPKRSKANNDAEVSEPKRRSERLVNKPAPPKAEPKPKKAPAKPKKTKEPKEPKEEEKKEEVPAENGETKADDDASATEDGDKKEDGE
InterPro domains: - IPR000079: High mobility group protein HMGN (family) [2-82]
Interaction partners: - Coiled-coil domain-containing protein 80
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0010043 (response to zinc ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Opioid receptor, delta 1b (B3DH72)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MEPPTVTVSDFSERYPLFLHNSSFLEEPAGLLSNWSGGSSELKAVRGSSAVAIAVSITALYSVICVVGLVGNVLVMYGVVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMGTWPFGELLCKVVIAIDYYNMFTSIFTLTMMSVDRYIAVCHPVRALDFRTPVKAKIINICVWILSSAVGFPVMVMAVTKELDSGKTICMLKFPDPEWYWDTVTKICVFIFAFVFPVLVITVCYGLMILRLKSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFIIVKTVVEIDQKNLLVVACWHLCIALGYMNSSLNPVLYAFLDENFKRCFREFCLPFRTRIEQNSFSKARSVIREPISVCAKSESIKQPT
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [71-324]
- IPR001418: Opioid receptor (family) [81-335]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [56-332]
Interaction partners: - Pro-opiomelanocortin protein
- Proenkephalin a
- Phosphatase and actin regulator 4A
- Proenkephalin-B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0007186 (G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Melanocortin receptor 5 (Q8JGW1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MNSSEWPTLSPNLSLSQANLSDESSRPKTSASAACEQVHIAPEVFLTLGLISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETIVIHLLANRSLVIEDHFIRQMDNVFDSLICISVVGSMWSLLAIAVDRYVTIFYALRYHNIMTVRRAGILIGSIWTFSTSCGIIFIIYSDTKPVVVCLVAMFFAMLLMMASLYSHMFLLARSHVKRMAALPGYNANIRQRASMKGAVTLTILLGIFIVCWAPFFLHLILMISCPRNIYCVCFMSHFNMYLILIMCNSVIDPLIYALRSQEMRKTFKEIVCCEGLRSFCNMVSKY
InterPro domains: - IPR000621: Melanocortin 5 receptor (family) [25-325]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [55-298]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [40-313]
- IPR001671: Melanocortin/ACTH receptor (family) [65-315]
- IPR001908: Melanocortin receptor 3-5 (family) [182-314]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0001653 (peptide receptor activity), GO:0008528 (G protein-coupled peptide receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0051716 (cellular response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0050795 (regulation of behavior), GO:0097009 (energy homeostasis), GO:0048521 (negative regulation of behavior), GO:0006091 (generation of precursor metabolites and energy), GO:0007186 (G protein-coupled receptor signaling pathway), GO:2000252 (negative regulation of feeding behavior), GO:0060259 (regulation of feeding behavior), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0006112 (energy reserve metabolic process), GO:0007189 (adenylate cyclase-activating G protein-coupled receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Pentraxin family member (A8KBB1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MLVLFFCLLSLTLAATEVGLGGKTLFFPTNTDSSYVQIDPEKPLSLSAFTLCMRVRLELLVDREVILFAYRTSEVDELNVWREKDGRVGLVIQSDKDAAMVHLSPRSTFQTHLCITWDSATGLTGFWEDGRRSVYQMYRKGYSIRPGGTVLLGQDPDSFVGSFDAAQSFVGEITDVQMWDYVLPSTQIKAVYSNQDDRVKGNVFDWNTIKYDVTGNVLVVPDN
InterPro domains: - IPR001759: Pentraxin domain (domain) [17-223]
- IPR030476: Pentaxin, conserved site (conserved_site) [112-119]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [19-221]
- IPR051005: Pentraxin domain-containing protein (family) [2-221]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0009617 (response to bacterium), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)
Protein: Protein-L-isoaspartate O-methyltransferase (F1QL05)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MQSVLRLAAVAVPMGLLLSRTMAWMSSGKTHVELITRLRDHGVIHNDRVFNAMLATDRGIYSRDHPYADSPQSIGYKATISAPHMHAHALEVLSDKLTEGASALDVGSGSGYLTACFARMVGPSGKVVGIDHIDQLVQSSVKNVQADDPELLATGRIKLVVGDGRFGFPDEAPYDAIHVGAAAPTLPKALLEQLKPGGRLVLPVGPEGGSQVLEQYDRQSDGTFLRKPLMGVVYVPLTDKQHQWPGDEL
InterPro domains: - IPR000682: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (family) [23-244]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [22-246]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0051998 (protein carboxyl O-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0008171 (O-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0010340 (carboxyl-O-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0035295 (tube development), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0043414 (macromolecule methylation), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0055123 (digestive system development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0048732 (gland development), GO:0035272 (exocrine system development), GO:0060429 (epithelium development), GO:0048565 (digestive tract development), GO:0061008 (hepaticobiliary system development), GO:0008213 (protein alkylation), GO:0001889 (liver development), GO:0001654 (eye development), GO:0001889 (liver development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Syntaphilin b (A0A8M9Q3K9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Single- pass membrane protein
Sequence: MSSPSNKRSGSGSRNFDYCRFIELDYTPMESGIMVSMRQSRGFLTPKSPERHCRRSPAPVSNRDPYGNASLSSSSNSGSCKGSDGSPTHRRHIKYTSCNDNHGIRPPPPEQYLTPLQQKEVCIRHLRARLKETIERLQDRDSEIDELRTQLTRMQEDWIEEECHRVEAQLALKEARREIHQLKEVVDVVKSSLGDTDTGVQKGFQDINLQNHKLESLLQSMELAQIGTTKTGEALAGGGLVGAGLEVSEGLAGSSEGSPARSLTRSSTYTKLSDQGGPERESNENGCDIPCLSGEGTQDSGFVCCGESGRGASKADLLLEAAFLSQETASLLNAYSRLPHSSTYEGLCSSEPRVVPLRCSSIGAGASVSLSHPCLSHHHLYLHHLREQGIQTEYDHAPASAPAHGPSTSFNSDLDTIAERTFRSQACSPTSTWMSDEGDDLESAATESAITATVATTSVVADFSTKSAPVAMGNWMPTASDSKGAATFPLMPIDSPDKETSFSEPLTDLPISTTALTTETIGSPVTNSTVQPQPITDPLPNPGTSPCSMQPLVGTEEDSLPQTTQPHSVLTETVVPGDNVINIGADDEDEGDEGATNTDSKSSGCGLPVKNYWSRHFLVDLLAVVVPVVPTVAWFCRGPHRDGQPIYHIGSLLRGCCTVALHSLRRGGGLRHYPAGGGGPGGMNI
InterPro domains: - IPR028197: Syntaphilin/Syntabulin (family) [58-319]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0009799 (specification of symmetry), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0009855 (determination of bilateral symmetry), GO:0009953 (dorsal/ventral pattern formation), GO:0030111 (regulation of Wnt signaling pathway), GO:0048262 (determination of dorsal/ventral asymmetry), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0048263 (determination of dorsal identity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton)
Protein: Caspase-3 (A0A8M2BKT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cytoplasm
Sequence: MSDVKPKGVDTVDARQSDAKESSSVTDPGLVQMDAKSHSDDNVDYQYKTNYPNLGQCLIINNKNFHKRTGMGVRNGTDEDAKKVFETFSQLGFKVGHYNDLTVSQMMALLNKASQEDHSKSAMFACVLLSHGDDGLIYGTDNSIELKRLFAHFRGDRCTSLVGKPKLFFIQACRGTDLDSGIECDGVGDEETQRIPVEADFLYAYSTAPGYYAWRNVANGSWFISSLCDMLLKYGKQLEIMQVMTRVNHKVALEFESSSNLPGFDGKKQIPCIVSMLTKELYFPK
InterPro domains: - IPR002398: Peptidase C14 family (family) [17-283]
- IPR033139: Peptidase family C14A, cysteine active site (active_site) [164-175]
- IPR001309: Peptidase C14, p20 domain (domain) [53-177]
- IPR029030: Caspase-like domain superfamily (homologous_superfamily) [45-283]
- IPR015917: Peptidase C14A, caspase catalytic domain (domain) [46-285]
- IPR011600: Peptidase C14, caspase domain (domain) [55-282]
- IPR002138: Peptidase C14, caspase non-catalytic subunit p10 (domain) [191-285]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009719 (response to endogenous stimulus), GO:0042221 (response to chemical), GO:0071495 (cellular response to endogenous stimulus), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0070887 (cellular response to chemical stimulus), GO:0043627 (response to estrogen), GO:0071310 (cellular response to organic substance), GO:0032870 (cellular response to hormone stimulus), GO:0071391 (cellular response to estrogen stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0099080 (supramolecular complex), GO:0036464 (cytoplasmic ribonucleoprotein granule), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043228 (non-membrane-bounded organelle), GO:0043025 (neuronal cell body), GO:0035770 (ribonucleoprotein granule), GO:0005739 (mitochondrion), GO:1990124 (messenger ribonucleoprotein complex), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0071598 (neuronal ribonucleoprotein granule), GO:0043005 (neuron projection), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0120111 (neuron projection cytoplasm)