Protein: Hsp70 nucleotide exchange factor FES1 (Factor exchange for SSA1 protein 1) (P38260)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:12052876, ECO:0000269|PubMed:14562095}.
Sequence: MEKLLQWSIANSQGDKEAMARAGQPDPKLLQQLFGGGGPDDPTLMKESMAVIMNPEVDLETKLVAFDNFEMLIENLDNANNIENLKLWEPLLDVLVQTKDEELRAAALSIIGTAVQNNLDSQNNFMKYDNGLRSLIEIASDKTKPLDVRTKAFYALSNLIRNHKDISEKFFKLNGLDCIAPVLSDNTAKPKLKMRAIALLTAYLSSVKIDENIISVLRKDGVIESTIECLSDESNLNIIDRVLSFLSHLISSGIKFNEQELHKLNEGYKHIEPLKDRLNEDDYLAVKYVL
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [40-283]
- IPR011989: Armadillo-like helical (homologous_superfamily) [37-284]
- IPR013918: Nucleotide exchange factor Fes1 (domain) [1-82]
- IPR050693: Hsp70 Nucleotide Exchange Factors and Inhibitors (family) [2-265]
Interaction partners: - Heat shock protein homolog SSE1
- HSP70 co-chaperone SNL1
- Heat shock protein homolog SSE2
- Heat shock protein SSA1
- Protein SIS1
- Heat shock protein STI1
- Heat shock protein 42
- Large ribosomal subunit protein uL23
- Heat shock protein SSA2
- Mitochondrial protein import protein MAS5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019208 (phosphatase regulator activity), GO:0019902 (phosphatase binding), GO:0019888 (protein phosphatase regulator activity), GO:0019903 (protein phosphatase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0006839 (mitochondrial transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0072655 (establishment of protein localization to mitochondrion), GO:0007005 (mitochondrion organization), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0006626 (protein targeting to mitochondrion), GO:0070585 (protein localization to mitochondrion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)