Protein: Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi) (Q92729)
Organism: Homo sapiens (Human)
Function: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Subcellular location: Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}.
Sequence: MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYESFFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEGLESR
InterPro domains: - IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [871-1445]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [1064-1430]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [284-585]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [189-282]
- IPR003961: Fibronectin type III (domain) [285-591]
- IPR000998: MAM domain (domain) [22-188]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [25-186]
- IPR057598: Receptor-type tyrosine-protein phosphatase U-like, Fn3 domain (domain) [586-730]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [187-592]
- IPR003595: Protein-tyrosine phosphatase, catalytic (domain) [1042-1438]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [1083-1388]
- IPR051622: Receptor-type Tyrosine-protein Phosphatases (family) [7-832]
- IPR000242: Tyrosine-specific protein phosphatase, PTPase domain (domain) [893-1441]
Interaction partners: - Mast/stem cell growth factor receptor Kit
- Catenin beta-1
- 6-pyruvoyl tetrahydrobiopterin synthase
- Segment polarity protein dishevelled homolog DVL-1
- Meprin A subunit beta
- Cadherin-17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0008013 (beta-catenin binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0019899 (enzyme binding), GO:0004725 (protein tyrosine phosphatase activity), GO:0019900 (kinase binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0051641 (cellular localization), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0007155 (cell adhesion), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0040013 (negative regulation of locomotion), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:2000145 (regulation of cell motility), GO:2000146 (negative regulation of cell motility), GO:0006979 (response to oxidative stress), GO:0009314 (response to radiation), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0051726 (regulation of cell cycle), GO:0104004 (cellular response to environmental stimulus), GO:0042127 (regulation of cell population proliferation), GO:0070887 (cellular response to chemical stimulus), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0045786 (negative regulation of cell cycle), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0031589 (cell-substrate adhesion), GO:0016477 (cell migration), GO:0071478 (cellular response to radiation), GO:0034599 (cellular response to oxidative stress), GO:0071559 (response to transforming growth factor beta), GO:0009416 (response to light stimulus), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0062197 (cellular response to chemical stress), GO:0006796 (phosphate-containing compound metabolic process), GO:0030334 (regulation of cell migration), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0030336 (negative regulation of cell migration), GO:0022607 (cellular component assembly), GO:0007160 (cell-matrix adhesion), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0050680 (negative regulation of epithelial cell proliferation), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0008104 (protein localization), GO:0051253 (negative regulation of RNA metabolic process), GO:0034330 (cell junction organization), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0071363 (cellular response to growth factor stimulus), GO:0016311 (dephosphorylation), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:2001141 (regulation of RNA biosynthetic process), GO:0006470 (protein dephosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0034329 (cell junction assembly), GO:0071482 (cellular response to light stimulus), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0010837 (regulation of keratinocyte proliferation), GO:0009411 (response to UV), GO:0010839 (negative regulation of keratinocyte proliferation), GO:0048041 (focal adhesion assembly), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0034614 (cellular response to reactive oxygen species), GO:0034394 (protein localization to cell surface), GO:0150115 (cell-substrate junction organization), GO:0007044 (cell-substrate junction assembly), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0007179 (transforming growth factor beta receptor signaling pathway), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0034644 (cellular response to UV)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0030054 (cell junction), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)