Protein: Multifunctional fusion protein [Includes: Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (L-glutamate gamma-semialdehyde dehydrogenase); L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88)] (Q9VNX4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MLRMMRSSSSRCSSLQQSLLKSSTRCLGSVIPDLKLKDFPIANEPILGYLKDSKERKALEQALKGTASSCEDIPIVIGGKEYKTPEVRYQVMPHDHQHKLASFYYADKKLIEKAIKTAVETQPKWDRVSIADRLKIWEKAADLMATTYRQDLNAATMLGQSKTAIQAEIDSAAELIDFIRMNAYFLKEVTKYQPISENIKVTKNSLRYRGIDGFIAAVSPFNFTAIGGNLSYTPALMGNGVLWKPSDTAMLSNWIIFKIMREAGVPDGVVNFVPADGPVFGDTITASPHLAGINFTGSVPTFNRLWKQVGNNIDNYVNFPRLTGECGGKNFHFIHASADVESVVTSTIRSAFEYCGQKCSACSRMYVPESLWPQIKEGLVCEAAKLKIGDVQDFSSFTSAVIDDKAFKRITGYIEHAKKSPNLEILAGGTYSDSKGYFVNPTIVLSKDPKDRIMTEEIFGPVLSIYVYKESDLLETMKLVHTSTKFALTGAVFGQDEDFVKCALQEFKMAAGNFYINDKSTGSVVGQQPFGGGRMSGTNDKAGGPHYILRWTSPQSIKETFVPLRDVNYPYMCE
InterPro domains: - IPR016160: Aldehyde dehydrogenase, cysteine active site (conserved_site) [352-363]
- IPR029510: Aldehyde dehydrogenase, glutamic acid active site (conserved_site) [324-331]
- IPR015590: Aldehyde dehydrogenase domain (domain) [90-556]
- IPR050485: Proline metabolism enzyme (family) [40-573]
- IPR016161: Aldehyde/histidinol dehydrogenase (homologous_superfamily) [39-558]
- IPR016162: Aldehyde dehydrogenase, N-terminal (homologous_superfamily) [44-559]
- IPR005931: Delta-1-pyrroline-5-carboxylate dehydrogenase (family) [41-572]
- IPR016163: Aldehyde dehydrogenase, C-terminal (homologous_superfamily) [327-524]
Interaction partners: - Delta-1-pyrroline-5-carboxylate synthase
- Proline dehydrogenase 1, mitochondrial
- Glutamate dehydrogenase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase
- Glutamine synthetase 2 cytoplasmic
- Pyrroline-5-carboxylate reductase
- Ornithine aminotransferase, mitochondrial
- Glutamine synthetase 1, mitochondrial
- Pyrroline-5-carboxylate reductase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0006560 (proline metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)