Protein: Signal recognition particle subunit srp72 (Signal recognition particle 72 kDa protein homolog) (O59787)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA) in presence of srp68 (By similarity). Can bind 7SL RNA with low affinity (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity).
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O76094}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38688}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P38688}.
Sequence: MSNHEEEIEELAQRIGKIEVGDTKSDIYQKVLNLIDIERYEHALKIIEKYLGETDAVYERAYCAFQLGKEDFSLEDKQFLQHLQAQKAYRLSDFSKALKIYEHLENDLPEQRADIRVNMLAAASQLPGLQLNNAVSLDDQDSVFNLATRYLTIGDWNQAIELLSSSLEKLENSDSNSEDHKSQINLCRLQLFFAYLQAGDNEKASKESLKISKDCLDETSQAIFVNNLISMSIDNPYISFRDLHGTNLEKALSSLLASQKKQFIRNLALLDMAVGKQRSVRKEKKRNPEESIYFSTILLREETKSLISPKKLPGYLENLFKSDSDNIVVALLLMQHKISNGNFRGALSIYQKLRTSLEASQSLSVLYSPGLVGLGDALHYKIQSTGFKSQLLHEAANYWRKQQSCEAKLLLCTRSLLAHLDERAPVSTIQDDMSVIDDLLQWKGPISELVSCKVAALCYLDKEIESGMDKYLVPTKDLITGIDVDDIEIRGVPVSAAIGPIKRSVEANSSNSSKKTRKRRKPTPKSFNPKATPDPQRWIPKRDRTNVKIKSKGKSMQGGVA
InterPro domains: - IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1-353]
- IPR026270: Signal recognition particle, SRP72 subunit (family) [7-560]
- IPR013699: Signal recognition particle, SRP72 subunit, RNA-binding (domain) [509-545]
Interaction partners: - Signal recognition particle subunit SRP54
- Uncharacterized protein C17H9.07
- Signal recognition particle subunit srp68
- Signal recognition particle subunit srp14
- Signal recognition particle sec65 subunit
- Signal recognition particle receptor subunit alpha homolog
- Signal recognition particle receptor subunit beta
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein eL8
- Large ribosomal subunit protein eL13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:1901564 (organonitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0015031 (protein transport), GO:0061024 (membrane organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)