Protein: Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein) (Q8NI22)
Organism: Homo sapiens (Human)
Function: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:12717434}. Endoplasmic reticulum {ECO:0000269|PubMed:12717434}. Golgi apparatus {ECO:0000269|PubMed:12717434}.
Sequence: MTMRSLLRTPFLCGLLWAFCAPGARAEEPAASFSQPGSMGLDKNTVHDQEHIMEHLEGVINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVHKEEGSEQAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSLQ
InterPro domains: - IPR011992: EF-hand domain pair (homologous_superfamily) [64-144]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [81-141]
- IPR002048: EF-hand domain (domain) [77-146]
- IPR052110: Multiple coagulation factor deficiency protein 2-like (family) [2-146]
Interaction partners: - Protein ERGIC-53
- Coagulation factor VIII
- VIP36-like protein
- Vesicular integral-membrane protein VIP36
- Coagulation factor V
- Protein ERGIC-53-like
- Cathepsin Z
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0003756 (protein disulfide isomerase activity), GO:0016860 (intramolecular oxidoreductase activity), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0016864 (intramolecular oxidoreductase activity, transposing S-S bonds), GO:0046914 (transition metal ion binding), GO:0005509 (calcium ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0048878 (chemical homeostasis), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0048585 (negative regulation of response to stimulus), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050878 (regulation of body fluid levels), GO:1901564 (organonitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0003013 (circulatory system process), GO:0006082 (organic acid metabolic process), GO:0008285 (negative regulation of cell population proliferation), GO:0019538 (protein metabolic process), GO:0003014 (renal system process), GO:0008217 (regulation of blood pressure), GO:0050878 (regulation of body fluid levels), GO:0008015 (blood circulation), GO:0043436 (oxoacid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)