Protein: Dihydroxyacetone phosphate acyltransferase (DAP-AT) (DHAP-AT) (EC 2.3.1.42) (Acyl-CoA:dihydroxyacetonephosphateacyltransferase) (Glycerone-phosphate O-acyltransferase) (Q9ES71)
Organism: Rattus norvegicus (Rat)
Function: Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:9459311}; Peripheral membrane protein {ECO:0000269|PubMed:9459311}; Matrix side {ECO:0000269|PubMed:9459311}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane. {ECO:0000269|PubMed:9459311}.
Sequence: MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRQVSDFKFAMKCYTPPLYRGITPCKPSDIKSIVLNSEEINYVIKQLSRESLTGVDVLREEANEILEEMSHKLRIGAIRFFAFVLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVILLPSHRSYIDFLMLSFVLYNYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRSGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYELLGIPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLSRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVAILLQNQLCMDFDALVEKTLWLKGLTQVFGGFLLWPDNKLPEEVVQSSILLHSNLATLVKDQVVLKVDSESSQMVNGLVPQHIAFLMCSAYRNQLLNVFARPSLVAVALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKTEVMQMTGKDIILTDKGNAVLQFLTGLFKPFVESYQILSKCLLHEEDYFSEKEYLVTARKFTRQLLDQDASQCYDALSSELQKNALAAFVRLGVVEKNKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL
InterPro domains: - IPR022284: Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase (family) [1-678]
- IPR041728: GPAT/DHAPAT, acyltransferase domain (domain) [133-338]
- IPR028353: Dihydroxyacetone phosphate acyltransferase (family) [1-678]
- IPR002123: Phospholipid/glycerol acyltransferase (domain) [142-284]
- IPR045520: GPAT/DHAPAT, C-terminal domain (domain) [292-641]
Interaction partners: - Alkyldihydroxyacetonephosphate synthase, peroxisomal
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase [NAD
- Glycerol-3-phosphate dehydrogenase, mitochondrial
- 1-acylglycerol-3-phosphate O-acyltransferase 3
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase
- 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
- 1-acylglycerol-3-phosphate O-acyltransferase 5
- Diacylglycerol kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016746 (acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0008374 (O-acyltransferase activity), GO:0016407 (acetyltransferase activity), GO:0016413 (O-acetyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0018904 (ether metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006662 (glycerol ether metabolic process), GO:1901503 (ether biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0046504 (glycerol ether biosynthetic process), GO:0006644 (phospholipid metabolic process), GO:0097384 (cellular lipid biosynthetic process), GO:0046485 (ether lipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0008611 (ether lipid biosynthetic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0006654 (phosphatidic acid biosynthetic process), GO:0046473 (phosphatidic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0042579 (microbody), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome)