Protein: T-cell surface glycoprotein CD5 (P51882)
Organism: Rattus norvegicus (Rat)
Function: Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL (By similarity). Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity). Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
Sequence: MDSHEVLLAATYLLGTLAAFCLGQSGRGFVGAQVMLSGSNSKCQGLVEVQMNGMKTVCSSSWRLSQDLWKNANEASTVCQQLGCGNPLALGHLTLWNRPKNQILCQGPPWSFSNCSTSSLGQCLPLSLVCLEPQKTTPLPTTTLPTTMPEPTAPPRLQLVPGHEGLRCTGVVEFYNGSRGGTILYKAKARPVDLGNLICKSLQCGSFLTHLSRIETAGTPAPAELRDPRPLPIRWEAQNGSCTSLQQCFQKTTVQEGSQALAVVCSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWAALCDSSAARGPGRWEELCQEQQCGNLISFHVMDADRTSPGVLCTQEKLSQCYQLQKKTHCKRVFITCKDPNPVGLAPGTVASIILTLVLLVVLMVMCGPLIYKKLVKKFRQKKQRQWIGPTGVNQSMSFHRSHTATVRSQVENPAASHVDNEYSQPPRNSRLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL
InterPro domains: - IPR036772: SRCR-like domain superfamily (homologous_superfamily) [30-369]
- IPR003566: T-cell surface glycoprotein CD5 (family) [1-491]
- IPR001190: SRCR domain (domain) [34-364]
Interaction partners: - CD19 molecule
- T-cell surface glycoprotein CD4
- T-cell surface antigen CD2
- Cd72 molecule
- C-C motif chemokine receptor 7
- Antigen-presenting glycoprotein CD1d
- T-cell surface glycoprotein CD3 epsilon chain
- Leukosialin
- Proto-oncogene tyrosine-protein kinase LCK
- Integrin alpha-D
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0008219 (cell death), GO:0051240 (positive regulation of multicellular organismal process), GO:0031294 (lymphocyte costimulation), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0002696 (positive regulation of leukocyte activation), GO:0012501 (programmed cell death), GO:0097190 (apoptotic signaling pathway), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0050865 (regulation of cell activation), GO:0050867 (positive regulation of cell activation), GO:0031295 (T cell costimulation), GO:0051251 (positive regulation of lymphocyte activation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0006915 (apoptotic process), GO:0051249 (regulation of lymphocyte activation), GO:0050870 (positive regulation of T cell activation), GO:0050863 (regulation of T cell activation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)