Protein: Polynucleotide kinase 3'-phosphatase, putative (Q585Q2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MKRARSPSPKGLSLATIADWKLLHNSVLALLPSAEQLKRSITSLPGENLCLKVAAFDLDDTLIMPKTGAVFPRDDPTDWKWLTPLVPTHLRVLHDGGFMVVIFSNQAGIGGKQWNEKKADVVKQKVVRLSKGLNIPLTAFLSTKDDIWRKPNVGMWTMLQEHASDILKEKVVIGSDTCGYAFYVGDAAGRKITTLAGRKKDFSCSDRKFAYNIGIPFFTPEEFYSCPEDKLLEERKKGSDDTPSVDGKVVSHRLLNVAQASCTVDWGGVGPTELSKLPKSYSGLTIHRILANGTKDIIEVSSPAAFHRASQEMIVFVGYPGCGKTTFFERFFEPHGYAHVNRDKLQTREKCLAEARRWWKAGKSVVIDNTNPSHEDCRVFVEVVKQDGSGRSPLPVRLFLFRISKEMSMHMSNVRARLGVAPKISRVAYNVYQSKFDSWTADSVRSMGIEELVEIPPVASFDGLPKDSKREFFLLS
InterPro domains: - IPR013954: Polynucleotide kinase 3 phosphatase (family) [52-224]
- IPR036412: HAD-like superfamily (homologous_superfamily) [52-226]
- IPR023214: HAD superfamily (homologous_superfamily) [34-230]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [294-469]
- IPR006551: Polynucleotide 3'-phosphatase (domain) [52-224]
- IPR006549: HAD-superfamily hydrolase,subfamily IIIA (domain) [52-175]
Interaction partners: - DNA repair protein, putative
- Protein artemis
- Enkurin domain-containing protein
- DNA polymerase
- Mitochondrial DNA polymerase beta-PAK
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0042578 (phosphoric ester hydrolase activity), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0043094 (cellular metabolic compound salvage), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0097014 (ciliary plasm), GO:0005634 (nucleus)