Protein: Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) (Protein phosphatase V) (PP-V) (Q64620)
Organism: Rattus norvegicus (Rat)
Function: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIG-I-mediated signaling activation.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:O00743}. Cytoplasm {ECO:0000250|UniProtKB:O00743}.
Sequence: MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
InterPro domains: - IPR004843: Calcineurin-like, phosphoesterase domain (domain) [47-239]
- IPR047129: Serine/Threonine protein phosphatase PP2A-like (family) [5-305]
- IPR006186: Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (domain) [19-289]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [2-305]
Interaction partners: - Protein phosphatase 6, regulatory subunit 3
- Protein phosphatase 6, regulatory subunit 1.
- Ankyrin repeat domain 28
- Immunoglobulin-binding protein 1
- Immunoglobulin
- Ankyrin repeat domain 52
- Protein phosphatase 6, regulatory subunit 2
- Serine/threonine-protein phosphatase 2A activator
- TIP41-like protein
- eIF-2-alpha kinase GCN2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0044877 (protein-containing complex binding), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0005521 (lamin binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0006793 (phosphorus metabolic process), GO:0034097 (response to cytokine), GO:0006796 (phosphate-containing compound metabolic process), GO:0071310 (cellular response to organic substance), GO:0070555 (response to interleukin-1), GO:0016311 (dephosphorylation), GO:0071345 (cellular response to cytokine stimulus), GO:0071347 (cellular response to interleukin-1)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)