Protein: ADAM10 endopeptidase (EC 3.4.24.81) (Q9VJW9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MSSKCAFNIVFVSIIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVTKDQYVHLKFASHGRDFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVSGPGSGAGSSSKSKSGKSAKAKDSKSQKSQQANNSRSSSKEKGVKPVRRNIVY
InterPro domains: - IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [430-658]
- IPR001762: Disintegrin domain (domain) [675-781]
- IPR036436: Disintegrin domain superfamily (homologous_superfamily) [675-778]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [405-673]
- IPR034025: ADAM10/ADAM17 catalytic domain (domain) [410-677]
- IPR049038: ADAM10, cysteine-rich domain (domain) [823-878]
- IPR051489: Disintegrin and Metalloproteinase Domain-Containing (family) [1-1013]
Interaction partners: - Neurogenic locus Notch protein
- Nicastrin
- Presenilin homolog
- Gamma-secretase subunit pen-2
- Furin-like protease 1, isoforms 1/1-X/2
- Protein serrate
- Furin-like protease 2
- Suppressor of hairless protein
- Tissue inhibitor of metalloproteinase
- Tyrosine-protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0002376 (immune system process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0090130 (tissue migration), GO:2000241 (regulation of reproductive process), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:2000243 (positive regulation of reproductive process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0002520 (immune system development), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048609 (multicellular organismal reproductive process), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:1903684 (regulation of border follicle cell migration), GO:0007276 (gamete generation), GO:0048638 (regulation of developmental growth), GO:0030707 (follicle cell of egg chamber development), GO:0007281 (germ cell development), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0001558 (regulation of cell growth), GO:0048513 (animal organ development), GO:1903688 (positive regulation of border follicle cell migration), GO:0090132 (epithelium migration), GO:0009966 (regulation of signal transduction), GO:2000147 (positive regulation of cell motility), GO:0000902 (cell morphogenesis), GO:0045165 (cell fate commitment), GO:0010632 (regulation of epithelial cell migration), GO:0001709 (cell fate determination), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0016043 (cellular component organization), GO:0048534 (hematopoietic or lymphoid organ development), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0090066 (regulation of anatomical structure size), GO:0007297 (follicle cell of egg chamber migration), GO:0016477 (cell migration), GO:0072001 (renal system development), GO:0032535 (regulation of cellular component size), GO:0010631 (epithelial cell migration), GO:0007419 (ventral cord development), GO:0030030 (cell projection organization), GO:0014016 (neuroblast differentiation), GO:0061318 (renal filtration cell differentiation), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048477 (oogenesis), GO:0048732 (gland development), GO:0030334 (regulation of cell migration), GO:0007298 (border follicle cell migration), GO:0001667 (ameboidal-type cell migration), GO:0048666 (neuron development), GO:0030855 (epithelial cell differentiation), GO:0014017 (neuroblast fate commitment), GO:0007400 (neuroblast fate determination), GO:0061387 (regulation of extent of cell growth), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0072359 (circulatory system development), GO:0008347 (glial cell migration), GO:0060537 (muscle tissue development), GO:0010634 (positive regulation of epithelial cell migration), GO:0030516 (regulation of axon extension), GO:0030335 (positive regulation of cell migration), GO:0007417 (central nervous system development), GO:0048542 (lymph gland development), GO:0060429 (epithelium development), GO:0048858 (cell projection morphogenesis), GO:0035051 (cardiocyte differentiation), GO:0030182 (neuron differentiation), GO:0007507 (heart development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:0061319 (nephrocyte differentiation), GO:0042063 (gliogenesis), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0098595 (perivitelline space)