Protein: Villin-like protein (O15195)
Organism: Homo sapiens (Human)
Function: Possible tumor suppressor.
Sequence: MDISKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTYQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEWKEAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGSPAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSSSVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMATWRQRQEKKQLGFF
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [8-721]
- IPR007122: Villin/Gelsolin (family) [12-840]
- IPR036180: Gelsolin-like domain superfamily (homologous_superfamily) [121-427]
- IPR003128: Villin headpiece (domain) [790-856]
- IPR007123: Gelsolin-like domain (domain) [23-699]
- IPR036886: Villin headpiece domain superfamily (homologous_superfamily) [782-856]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030029 (actin filament-based process), GO:0051094 (positive regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0030048 (actin filament-based movement), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0043207 (response to external biotic stimulus), GO:0030154 (cell differentiation), GO:0051014 (actin filament severing), GO:0070848 (response to growth factor), GO:0071495 (cellular response to endogenous stimulus), GO:0051130 (positive regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0030036 (actin cytoskeleton organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:2000147 (positive regulation of cell motility), GO:0044087 (regulation of cellular component biogenesis), GO:0010632 (regulation of epithelial cell migration), GO:0009888 (tissue development), GO:0009617 (response to bacterium), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0032535 (regulation of cellular component size), GO:0022604 (regulation of cell morphogenesis), GO:0043254 (regulation of protein-containing complex assembly), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0031344 (regulation of cell projection organization), GO:0070849 (response to epidermal growth factor), GO:0043244 (regulation of protein-containing complex disassembly), GO:0032956 (regulation of actin cytoskeleton organization), GO:0030334 (regulation of cell migration), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0030855 (epithelial cell differentiation), GO:0022607 (cellular component assembly), GO:0031333 (negative regulation of protein-containing complex assembly), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0032233 (positive regulation of actin filament bundle assembly), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0032231 (regulation of actin filament bundle assembly), GO:0031346 (positive regulation of cell projection organization), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0010634 (positive regulation of epithelial cell migration), GO:0070252 (actin-mediated cell contraction), GO:0030335 (positive regulation of cell migration), GO:0033043 (regulation of organelle organization), GO:0043243 (positive regulation of protein-containing complex disassembly), GO:0043933 (protein-containing complex organization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0022411 (cellular component disassembly), GO:0097435 (supramolecular fiber organization), GO:0071363 (cellular response to growth factor stimulus), GO:0007015 (actin filament organization), GO:0008360 (regulation of cell shape), GO:0032272 (negative regulation of protein polymerization), GO:0030835 (negative regulation of actin filament depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:1901881 (positive regulation of protein depolymerization), GO:0051494 (negative regulation of cytoskeleton organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1901879 (regulation of protein depolymerization), GO:0032271 (regulation of protein polymerization), GO:0065003 (protein-containing complex assembly), GO:0030837 (negative regulation of actin filament polymerization), GO:0030832 (regulation of actin filament length), GO:0008154 (actin polymerization or depolymerization), GO:1901880 (negative regulation of protein depolymerization), GO:0007010 (cytoskeleton organization), GO:1902745 (positive regulation of lamellipodium organization), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0032984 (protein-containing complex disassembly), GO:0030836 (positive regulation of actin filament depolymerization), GO:0110053 (regulation of actin filament organization), GO:0051495 (positive regulation of cytoskeleton organization), GO:0071364 (cellular response to epidermal growth factor stimulus), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0051125 (regulation of actin nucleation), GO:0051693 (actin filament capping), GO:0038127 (ERBB signaling pathway), GO:0051261 (protein depolymerization), GO:0030834 (regulation of actin filament depolymerization), GO:1902743 (regulation of lamellipodium organization), GO:0030833 (regulation of actin filament polymerization), GO:0051258 (protein polymerization), GO:0030042 (actin filament depolymerization), GO:0030041 (actin filament polymerization), GO:0051016 (barbed-end actin filament capping), GO:0007173 (epidermal growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031252 (cell leading edge), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0032432 (actin filament bundle), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0001726 (ruffle), GO:0030027 (lamellipodium), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0098858 (actin-based cell projection), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030175 (filopodium), GO:0005902 (microvillus), GO:1903561 (extracellular vesicle), GO:0015629 (actin cytoskeleton)