Protein: Protein Wnt-1 (P34888)
Organism: Caenorhabditis elegans
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1. Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons. Also acts with the Wnt ligand egl-20 to direct HSN neuron migration. Acts through the Wnt receptor cfz-2 to direct ALM migration. Also plays a role in axon growth and guidance in HSN and male CP neurons. In addition, together with Wnt ligand cwn-2, negatively regulates developmental neurite pruning of AIM neurons probably by acting as a ligand for receptor tyrosine kinase cam-1. Probably by activating the Wnt/Frizzled pathway, may regulate vulva development. May act redundantly with other Wnt ligands such as cwn-2 and mom-2 to control seam cell polarity.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q2LMP1}. Cytoplasm {ECO:0000269|PubMed:22022276}. Cell membrane {ECO:0000269|PubMed:22022276}; Peripheral membrane protein {ECO:0000269|PubMed:22022276}.
Sequence: MLKSTQVILIFILLISIVESLSWLALGLAANRFDRDKPGTSCKSLKGLTRRQMRFCKKNIDLMESVRSGSLAAHAECQFQFHKRRWNCTLIDPVTHEVIPDVFLYENTRESAFVHAISSAAVAYKVTRDCARGISERCGCDYSKNDHSGKSQFQYQGCSDNVKFGIGVSKEFVDSAQRRVLMMKDDNGTSLLGPSQLSADGMHMINLHNNQAGRQVLEKSLRRECKCHGMSGSCEMRTCWDSLPNFRHIGMAIKDKFDGAAEVKVVKEDGIEKPRIVMKNSQFKRHTNADLVYMTPSPDFCESDPLRGILGTKGRQCTLAPNAIDDCSLLCCGRGYEKKVQIVEEKCNCKFIYCCEVRCEPCQKRIEKYLCL
InterPro domains: - IPR018161: Wnt protein, conserved site (conserved_site) [225-234]
- IPR043158: Wnt, C-terminal domain (homologous_superfamily) [312-372]
- IPR005817: Wnt (family) [41-372]
Interaction partners: - Frizzled-2
- Frizzled-4
- Frizzled-4
- Protein mom-5
- Secreted frizzled-related protein 1
- Protein wntless homolog
- Protein-serine O-palmitoleoyltransferase porcupine
- Inactive tyrosine-protein kinase RYK
- Tyrosine-protein kinase receptor cam-1
- DiSHevelled related
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007163 (establishment or maintenance of cell polarity), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0045926 (negative regulation of growth), GO:0051094 (positive regulation of developmental process), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0001708 (cell fate specification), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0002700 (regulation of production of molecular mediator of immune response), GO:0060627 (regulation of vesicle-mediated transport), GO:0032886 (regulation of microtubule-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0010453 (regulation of cell fate commitment), GO:0044087 (regulation of cellular component biogenesis), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0040028 (regulation of vulval development), GO:0046662 (regulation of oviposition), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0007548 (sex differentiation), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0048639 (positive regulation of developmental growth), GO:0009967 (positive regulation of signal transduction), GO:0007276 (gamete generation), GO:0045597 (positive regulation of cell differentiation), GO:0009798 (axis specification), GO:0051049 (regulation of transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0198738 (cell-cell signaling by wnt), GO:0050920 (regulation of chemotaxis), GO:0001558 (regulation of cell growth), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0051649 (establishment of localization in cell), GO:0051130 (positive regulation of cellular component organization), GO:0030307 (positive regulation of cell growth), GO:0090598 (male anatomical structure morphogenesis), GO:0009891 (positive regulation of biosynthetic process), GO:0045165 (cell fate commitment), GO:2000026 (regulation of multicellular organismal development), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0016358 (dendrite development), GO:0045596 (negative regulation of cell differentiation), GO:0048640 (negative regulation of developmental growth), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:0050795 (regulation of behavior), GO:0031099 (regeneration), GO:0048680 (positive regulation of axon regeneration), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:0030030 (cell projection organization), GO:0097402 (neuroblast migration), GO:0043254 (regulation of protein-containing complex assembly), GO:0097402 (neuroblast migration), GO:0016055 (Wnt signaling pathway), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0007369 (gastrulation), GO:0045138 (nematode male tail tip morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0030334 (regulation of cell migration), GO:0001714 (endodermal cell fate specification), GO:0050678 (regulation of epithelial cell proliferation), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0061387 (regulation of extent of cell growth), GO:1902903 (regulation of supramolecular fiber organization), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0030517 (negative regulation of axon extension), GO:0051252 (regulation of RNA metabolic process), GO:0048858 (cell projection morphogenesis), GO:2000027 (regulation of animal organ morphogenesis), GO:0048843 (negative regulation of axon extension involved in axon guidance), GO:1901890 (positive regulation of cell junction assembly), GO:0061458 (reproductive system development), GO:0031344 (regulation of cell projection organization), GO:0097402 (neuroblast migration), GO:1901888 (regulation of cell junction assembly), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0045138 (nematode male tail tip morphogenesis), GO:0051960 (regulation of nervous system development), GO:1902667 (regulation of axon guidance), GO:0009855 (determination of bilateral symmetry), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0022008 (neurogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0042659 (regulation of cell fate specification), GO:0031346 (positive regulation of cell projection organization), GO:0060972 (left/right pattern formation), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0060284 (regulation of cell development), GO:0031326 (regulation of cellular biosynthetic process), GO:0030516 (regulation of axon extension), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0060429 (epithelium development), GO:0010721 (negative regulation of cell development), GO:0010638 (positive regulation of organelle organization), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0042661 (regulation of mesodermal cell fate specification), GO:0051493 (regulation of cytoskeleton organization), GO:2001141 (regulation of RNA biosynthetic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0051963 (regulation of synapse assembly), GO:0007411 (axon guidance), GO:0010977 (negative regulation of neuron projection development), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0035545 (determination of left/right asymmetry in nervous system), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1903354 (regulation of distal tip cell migration), GO:0010976 (positive regulation of neuron projection development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:0006355 (regulation of DNA-templated transcription), GO:0008361 (regulation of cell size), GO:0050771 (negative regulation of axonogenesis), GO:0031175 (neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0005615 (extracellular space)