Protein: MAP kinase-activating death domain protein (Rab3 guanyl-nucleotide exchange factor) (Q9VXY2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Guanyl-nucleotide exchange factor that regulates small GTPases (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q8WXG6}. Cytoplasm {ECO:0000250|UniProtKB:Q8WXG6}.
Sequence: MSDQQKASLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIERPSSAAGSAGAGNDRPGNGGPGGHGGGAGGGAGGGGRGGRRSSAFRRESWRKSMERSSDSAFSSDYRSNVAPSDSDRELTSRRDSDQQRLHSHHSHHQPHHPSASPAVPKLGLMAPSADSESGGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLDSTKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQPTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYPEGIADAVASKEEEDEERADSPVSSSSSRSDLSSPSFNRDSEFDFQPKGGQTLGSTTVGSGAAAPSFELATPLAMRLEATIKMASIEQESDTVSTATGKTIAAGSKLQRHPSDSESRPEKKIPPPLTPPVKQPGVSNILARTGSSGSSSSSPGRQSSQSSLFENFASHAKELVRETTRQSSQEGLLAHVDKFTLHAKKAAGEASKQALEVSKQAAGVSKNTLEDLTYVGKSTLGDLTKTAKEAATKKGIIKIEEHSAGGAGPPPKSPGSQLATHKQVQQSGGQGGGNNFFSAIGTDFNGLASSTSTMFSGMFGKKSQQKQVPVQQKQPNVSAGKAKSGINFDPFPGRKGLVERTPLIKHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKIAPDDHIDDVCVTKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKEINEGSDMSSSLLSSHAASPMGSRENLRSPSSPNGSHSALGSEWASPQESRKSSTQLAHGGPGGSHSGAPINRRLSSADSQDGQSTTEMFKDMLSQKRSALKNMLTSFDSDTTTSKDSKKSSGNLWSGKSTLSAGFRYTGGHLINTSSSPSPDSPRVYLFEGLLGKDRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQICYSVLCVFSYVAAGQDQKKNPVVITPQIQDIHAQQKQKHQQQQQHQQPQQQQQPHQTTTQQNQPTAVASAVPTTTAPAGQVNPNRMTAKSQAGSISIRHTVPMQKPTITMSTVQPQARMPAQVATASVPVTVPVPPTPAPPTSNPAKLPQLPPRVPSQPSTESLASISSPPPKLRTPMSAPPGPPPAIPPRTGAISRSGSVPAARSFVRQASANSTPPQYTPQPPPPFVIPKRHSGLARASTLSSSTSPSMSSSSASNHPGHSQSQQRASHGSVAAVLQSMPEAEPGYGSGSGSISGSSSGSGSASGSIASASPQAHRKH
InterPro domains: - IPR001194: cDENN domain (domain) [257-486]
- IPR057469: MAP kinase-activating death domain protein, C-terminal PH-like domain (domain) [1686-1775]
- IPR005113: uDENN domain (domain) [10-111]
- IPR037516: Tripartite DENN domain (domain) [25-678]
- IPR056574: MAP kinase-activating death domain protein, death domain (domain) [1490-1565]
- IPR005112: dDENN domain (domain) [601-671]
- IPR039980: MAP kinase-activating death domain protein (family) [1-1409]
- IPR043153: DENN domain, C-terminal lobe (homologous_superfamily) [379-536]
Interaction partners: - Ras-related protein Rab-3
- Rab3 GTPase-activating protein non-catalytic subunit
- EG:80H7.4 protein
- Rabconnectin-3A
- LD21953p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0140678 (molecular function inhibitor activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0005085 (guanyl-nucleotide exchange factor activity), GO:0030695 (GTPase regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0023051 (regulation of signaling), GO:0030029 (actin filament-based process), GO:0048522 (positive regulation of cellular process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0051668 (localization within membrane), GO:0030036 (actin cytoskeleton organization), GO:0009891 (positive regulation of biosynthetic process), GO:0009894 (regulation of catabolic process), GO:0046907 (intracellular transport), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0000278 (mitotic cell cycle), GO:0009896 (positive regulation of catabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0043244 (regulation of protein-containing complex disassembly), GO:0010506 (regulation of autophagy), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0016197 (endosomal transport), GO:0010508 (positive regulation of autophagy), GO:0030866 (cortical actin cytoskeleton organization), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0031331 (positive regulation of cellular catabolic process), GO:0016192 (vesicle-mediated transport), GO:0043243 (positive regulation of protein-containing complex disassembly), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:1901098 (positive regulation of autophagosome maturation), GO:0016241 (regulation of macroautophagy), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0007010 (cytoskeleton organization), GO:1901096 (regulation of autophagosome maturation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0051056 (regulation of small GTPase mediated signal transduction), GO:0032456 (endocytic recycling), GO:0016239 (positive regulation of macroautophagy), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0032784 (regulation of DNA-templated transcription elongation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0046578 (regulation of Ras protein signal transduction), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0030865 (cortical cytoskeleton organization), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0034243 (regulation of transcription elongation by RNA polymerase II), GO:0032786 (positive regulation of DNA-templated transcription, elongation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0032968 (positive regulation of transcription elongation by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)