Protein: DNA-directed DNA polymerase (EC 2.7.7.7) (Q8MWB2)
Organism: Trypanosoma brucei
Function: Not known
Sequence: MLRRLFKPQLMVPWSRQPPTCCSSQIINIISRGLSQRGEPLGAAAPSSVSSVSVPPVASLHTPVMHSNAFAASEVKKLLAKAQYSLFTLGWNPGTDDYCIYCATTNELVRAKKDTLWKAIFWMEGRIGDDYIAGLLFPSDGTPALTEVAAMVREKCRRQVVVAPDTWGICYLTLKNQRDFVRGMELPASLEHAAFLLMRAMFNSSLIEPSVFDVTSGAYISASCADSVSAARDCLVSWWVLFNVHKKFGTSGSRKLIDPVEQIVRRVVKTVNVFVVDINVRVGKGTISEGFTMIVTIYDAQRRSQSVHMIRSLAEESAKRNTLNGLLFGEGTSAISLFVPTDRTKSSQLLAFARSCRPSCPFFVTEPSSLTPFFSGAPVTDGLSEQSDPRSTWALIRTNCFAQCPGRRLEEVLDRKLLQGFTAVANRLYSDRLHRVSPALMSAASSIPLREEPRVAWERVASLVEEERKNPVAHVNKSAFLNNVTITDAEVVFRLQQWHSTIYESPDRLEREREALEGLQRYLVVDLETTTVRRYKRVANPFTKENYVVLSGARDYRGQVFMPSRYYSRNVALRYDDLHVTSTHSLVKGSSKHSLFLPPLDDYDVLVGHNIKFDLLHMWRDVELRRFLKRGGKIWDTMYAEYLLTGHEVKLGHGAGLEEVAKSYGGQTPKLDAVKQAWSSGKDTCEIPYRTLTQYLHGDLENTELIFKKHIERALAQRQVVIILARMDGLLCTTEMEYNGLKTNVQLALSQSNELMCKVKELRRHLDNSIPKEISIDCRKYFNWASNQHLIAFFFGGKLKLSTNARESRLLPGEVFERHTLYARPEDYDKTEFPKGVFLRPPVYVVGPADCLMATGVSLDKGTKFFKMYFEAYVKQAGFRKSSSVTDSLRRAMVSVSRIDQEKCSNPDALVNLLPKRHLFLFAAFTPTSDGTISKLFLKNAITGESLTIAGDCANKVERLRAFMEGQVEAHTEMLVDADGDGSAPANNNAFADAHITILARDAPFSCARLLHSDEGISAYLSLHDGLNPQEDVGQRYVITLADTVSTLSYYRYMYGSDTEAAYADKTKVDESKLVVPMKALPRPCSSRGATSEAFKKKLVQEAAMKPEDWCNLYIDIFLHIGHAALCRESLETEAGSKKARKSKGKGGIRTPGDLPILLRERSAFIGYYNSLPDDERKKLALMTMLGRTCGTAFDAFAVMCSHDDIVEVNIGGRLNQYVPSQLDAEQVMRKFRSPTTRQLQVGEDSLTYFKKTHGDKTAETILELRAMEKLIGTYYENTDDGTGMVSLVHDDDSCIHHELIHNKTNTGRLASANPNCQNIPKEDKSPLREMFVSRYGEKGMCIEADYSQLEVVALAVLANDQQMLEDLRSNVDFHCKRVAMMRPDLQYTEILKKAKKDKEPEFVKLRQQAKIFSFQRQYGAGVKMISESTGLTQDQVRHLIEKERETYRGVDVFNSMVALSANKFDASLQNGSRNVRGHQIFKGMFPVITGSRYIFTESDVPEGLLRNKSLAVKSTNFSPTHLKNYPVQGFAGEIVQIMLGVLWRHFLRKDNYGGLAVLINTVHDCVWIDCHMDVLQDVVLETDGIMSSVRDVLNRLYPEMEVSVDFPCDVVAGENMGALRPVVIEETL
InterPro domains: - IPR043502: DNA/RNA polymerase superfamily (homologous_superfamily) [726-1619]
- IPR019760: DNA-directed DNA polymerase, family A, conserved site (conserved_site) [1407-1426]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [503-712]
- IPR001098: DNA-directed DNA polymerase, family A, palm domain (domain) [1234-1616]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [502-737]
- IPR002298: DNA polymerase A (family) [1233-1622]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016740 (transferase activity), GO:0140097 (catalytic activity, acting on DNA), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0034061 (DNA polymerase activity), GO:0016779 (nucleotidyltransferase activity), GO:0003887 (DNA-directed DNA polymerase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0090304 (nucleic acid metabolic process), GO:0007005 (mitochondrion organization), GO:0006260 (DNA replication), GO:0032042 (mitochondrial DNA metabolic process), GO:0006264 (mitochondrial DNA replication), GO:0006261 (DNA-templated DNA replication), GO:0000002 (mitochondrial genome maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)