Protein: Zinc transporter 7 (Q5MNV6)
Organism: Gallus gallus (Chicken)
Function: Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Golgi apparatus, trans-Golgi network. Sarcoplasmic reticulum. Mitochondrion
Sequence: MLPLSIKDDEYKPPRLNLFRKMSGWFRSILADKTSRNLFFFLCLNLSFAFVELLYGVWSNSLGLISDSFHMFFDCTALLAGLAASVISKWRSNDAFSYGYVRAEVLAGFVNGLFLIFTAFFIFSEGVERALEPPDVHHERLLPVSILGFIVNLIGIFVFQHGGHGHSHGSGHEHSHSLFNGGLSHGHSHRGHGHSHEHKHGHTHDHGHSHGLSHGQDYCHDDHCLEGMTGSSKQILQGVFLHIVADTLGSIGVIISAILMQNYGLMIADPICSMLIALLIGVSIVPLLKESIGILMQRTPPSLENALPQCYQRVQQLQGVYSLHDPHFWTLCTDVYIGTLKLLVAPDADGRWILSQTHNIFTQAGVRQLYIQIDVAAM
InterPro domains: - IPR002524: Cation efflux (family) [35-374]
- IPR027469: Cation efflux transmembrane domain superfamily (homologous_superfamily) [33-297]
- IPR058533: Cation efflux protein, transmembrane domain (domain) [38-296]
- IPR045316: Zinc transporter Msc2-like (family) [17-195]
Interaction partners: - Zinc transporter ZIP9
- Zinc transporter ZIP13
- Metallothionein
- Metallothionein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0055085 (transmembrane transport), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098771 (inorganic ion homeostasis), GO:0034220 (monoatomic ion transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098655 (monoatomic cation transmembrane transport), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0006882 (intracellular zinc ion homeostasis), GO:0006812 (monoatomic cation transport), GO:0071577 (zinc ion transmembrane transport), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)