Protein: Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) (O75381)
Organism: Homo sapiens (Human)
Function: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:19197237}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q642G4}.
Sequence: MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
InterPro domains: - IPR025655: Peroxisomal membrane protein 14 (family) [7-369]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [13-80]
- IPR006785: Peroxisome membrane anchor protein Pex14p, N-terminal (domain) [25-68]
Interaction partners: - Peroxisomal targeting signal 1 receptor
- Peroxisomal biogenesis factor 19
- PEX5-related protein
- Peroxisomal membrane protein PEX13
- Peroxisomal targeting signal 2 receptor
- Peroxisome assembly protein 12
- Peroxisome biogenesis factor 2
- Peroxisomal ATPase PEX6
- Peroxisome biogenesis factor 10
- Peroxisomal biogenesis factor 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0005215 (transporter activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0140318 (protein transporter activity), GO:0008320 (protein transmembrane transporter activity), GO:0022884 (macromolecule transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0055085 (transmembrane transport), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0046907 (intracellular transport), GO:0071806 (protein transmembrane transport), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0045184 (establishment of protein localization), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0071702 (organic substance transport), GO:0065002 (intracellular protein transmembrane transport), GO:0008104 (protein localization), GO:0044743 (protein transmembrane import into intracellular organelle), GO:0043574 (peroxisomal transport), GO:0006996 (organelle organization), GO:0006625 (protein targeting to peroxisome), GO:0033365 (protein localization to organelle), GO:0006605 (protein targeting), GO:0007031 (peroxisome organization), GO:0016558 (protein import into peroxisome matrix), GO:0072663 (establishment of protein localization to peroxisome), GO:0015919 (peroxisomal membrane transport), GO:0072662 (protein localization to peroxisome)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0042579 (microbody), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0098588 (bounding membrane of organelle), GO:0031903 (microbody membrane), GO:0005778 (peroxisomal membrane)