Protein: Degenerin-like protein unc-105 (Uncoordinated protein 105) (Q09274)
Organism: Caenorhabditis elegans
Function: Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MAEDRIKSKLRRPASIESTMSSRTKPRHKPSPMSILMPHLMVGESFRKYRPHGLRNIRMNGHLDWNQLRKSFEKQSTFHGISHAATADGKWRWFWYTAFTICLLALLIQIFFLISKYRQYGKTVDLDLKFENAPFPSITICNLNPYKKSAIQSNPNTKAMMEAYSRRIGSGDKTEGIAAALSATGGLHAKVRRAKRKAKGKPRLRDRRYHQAFAQCLCDIEQLTGDRKGSCFAAFKGKIEIDTNNTAGFMNLHTSRCLCQLDTVSKALWPCFPYSSWKEKLCSECVDNTGHCPMRFYKGNELYENIKEQVDLCLCHKEYNHCVSTRDDGIILEISPNDELNDLDIGKKIASQLSAQQEKQAEVTTTEAPTVTQALGFEELTDDIAITSQAQENLMFAVGEMSEKAKESMSYELDELVLKCSFNQKDCQMDRDFTLHYDNTFGNCYTFNYNRTAEVASHRAGANYGLRVLLYANVSEYLPTTEAVGFRITVHDKHIVPFPDAFGYSAPTGFMSSFGVRMKQFIRLEPPYGHCRHGGEDAATFVYTGFQYSVEACHRSCAQKVIVEACGCADPMYPVAEMFGNNTKPCQAVNMDQRECLRNTTLWLGELYSKGKEAIIPDCYCHQPCQETNYEVTYSSARWPSGSAKVMECLPGDFLCLEKYRKNAAMVQIFYEELNYETMQESPAYTLTSVLADLGGLTGLWIGASVVSLLEIVTLIVFATQAYVRKRKGSISAQSHHSVPVHRASRVSLNTLHKSSTTQSVKLSVMDIRSIKSIHSNHSSKSKQSILIEDLPPAIQEQSDDEEETTESSRTNGSCRYLAPGEDLPCLCKYHPDGSIRIMKALCPVHGYMVRRNYDYSVSNSEEEDAEDEVHREPEPFYSAPYEHRKK
InterPro domains: - IPR020903: Epithelial sodium channel, conserved site (conserved_site) [548-568]
- IPR004726: Degenerin (family) [71-715]
- IPR001873: Epithelial sodium channel (family) [70-726]
Interaction partners: - Acid-sensing ion channel 1-like
- Acid-sensing ion channel 1
- Voltage-dependent T-type calcium channel subunit alpha
- DEgenerin Like
- DEgenerin Like
- Innexin unc-9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005272 (sodium channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015280 (ligand-gated sodium channel activity), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0048583 (regulation of response to stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0051606 (detection of stimulus), GO:0003008 (system process), GO:0007610 (behavior), GO:0009581 (detection of external stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0044057 (regulation of system process), GO:0007638 (mechanosensory behavior), GO:0032101 (regulation of response to external stimulus), GO:0009582 (detection of abiotic stimulus), GO:0031646 (positive regulation of nervous system process), GO:0050877 (nervous system process), GO:0048520 (positive regulation of behavior), GO:0009612 (response to mechanical stimulus), GO:0050795 (regulation of behavior), GO:0050906 (detection of stimulus involved in sensory perception), GO:0050974 (detection of mechanical stimulus involved in sensory perception), GO:0031644 (regulation of nervous system process), GO:0050982 (detection of mechanical stimulus), GO:0007600 (sensory perception), GO:0051931 (regulation of sensory perception), GO:0050954 (sensory perception of mechanical stimulus), GO:0050976 (detection of mechanical stimulus involved in sensory perception of touch), GO:0050975 (sensory perception of touch)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0036477 (somatodendritic compartment), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0005886 (plasma membrane)