wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Lupanine 17-hydroxylase [cytochrome c] (EC 1.17.2.2) (Quinohemoprotein lupanine hydroxylase) (Q934G0)
Organism: Pseudomonas sp
Function: Catalyzes the first reaction in the catabolism of the alkaloid lupanine. It dehydrogenates lupanine, which can then be hydrated to produce 17-hydroxylupanine.
Subcellular location: Periplasm {ECO:0000269|PubMed:12686118}.
Sequence: MSANKNIWIIRLGVAFVCVAIGAAQANEKDGSAVTSGNWSLLGGGNEQHYFSALKDVNKSNVKNLGLSWFTDMEAGDGLVGNPLVADGVIYQGGPPGKIYANDLKTGKNLWTYTPEVQYDKDTSWTGFWGTHVNRGLAVDDDNVYIGSYCKLLAVSRTTHKLTWSSQSCDPKKMQAITGAPRVGGGKVFIGNASGDFGGDRGHLDAFDAKTGKHLWRFYTMPGDPSKPFENDLLAKASKTWGTDYWKYTKGGVSPWDAITYDEASDTLYFGTDGPSPWSPAQRAPDAGDELFSHSIIAVDASTGAYKWHFQTVQNDGSNMSATMHIMLADLPVEGVSKRVVMTAPKNGYFYVLDASTGKFISADHYVPVNWTKGLDPKTGRPIPSNEANYWERPGEMTIPLPGDVGGHNWEAMAYNPELRTVYIPSTLVPVTVVASKDTGELDLDYYYGMRPDATIKTQGDLVAWDPLLQKEKWRAKRSLPVNGGVLATAGGLVFQGTGDGHFEAFDANTGEKLWSFHVGGSILAAPTTVEVDGDQYLIVASGNGGASGMRGIPRLMNNLQSQGPARLLAFRLGGKTELPITSTPDFPKPQYPKPTSAMAESGRHIFNANACGACHGFNAEGSTPGLPDLRRSDKLDLAVMKSIVIDGAFKPLGMPGHPHISDADLQALQAFILQKAWTAYDTQQTLKTSDTGAQ
InterPro domains: - IPR009056: Cytochrome c-like domain (domain) [598-677]
- IPR011047: Quinoprotein alcohol dehydrogenase-like superfamily (homologous_superfamily) [33-595]
- IPR018391: Pyrrolo-quinoline quinone beta-propeller repeat (repeat) [82-518]
- IPR036909: Cytochrome c-like domain superfamily (homologous_superfamily) [575-694]
- IPR002372: Pyrrolo-quinoline quinone repeat domain (domain) [39-537]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0048038 (quinone binding), GO:0097159 (organic cyclic compound binding), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0009055 (electron transfer activity), GO:0046906 (tetrapyrrole binding), GO:0043177 (organic acid binding), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0020037 (heme binding), GO:0031406 (carboxylic acid binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044281 (small molecule metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0006066 (alcohol metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0034308 (primary alcohol metabolic process), GO:0006067 (ethanol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Stevor (C0H5N4)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MYYLKMLLFTFLINTLVLQHYENYLNNHYNVSLIQNNTKRTTIHSRLLAQTKNHNPHYHNDPELKEIIDKMNEEAIKKYQQTHDPYKQLKDVVEKNGTKYTGGNDVEPMSTLEKELLETYEETFGNKSDMLKLGKYKNDDDKSDDSSSCGCTNINNMKLAKTKGRDKYLKHLKGRCTRGIYISSLTTVILTTIALHTAKAAALAKFVESAKTCASYMTIFNMLNAGNLNTAIQAGGGICTSAYSDIVLPAANAALSAIYPCGIAALVLLILTVVLIILYIWLYRRRKRSWKHECKKHLCK
InterPro domains: - IPR006374: Variant surface antigen Stevor (family) [1-300]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0051701 (biological process involved in interaction with host), GO:0020013 (modulation by symbiont of host erythrocyte aggregation), GO:0044003 (modulation by symbiont of host process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part), GO:0020036 (Maurer's cleft)
Protein: Solute carrier family 17 member 3 (A0A0G2JY28)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MATVVELSPTSEQCEFVLGLPVNKKTPPRKVPSLCSMRYSIAFIAHICNFTLIAQNSIISITMVAMVNNTDQPSHLNSSTEWFPDGLNGDQHEASKHLSIKGAGYGGQFALWQKWAPPNERSRLCSIAMSGMILGIFAVLLVGGIISEALGWPFVFYIFGSIGVVCCLLWLILVYDDPVSHPWISSPEKEYILSSLDQQFNSEEQPLPIKAMLKSLPLWSMCLCSMTHQWLVNTLIIYTPTYISSVFKVNIRDNGLLSSLPFFVAWVIGILGGLLADFLLSKNFRLITVRKIITILGNTPPAALVVALPYVQSSYIATTTFLTLSCGLSPLCQSGVYINALDIAPRYASLLMGTSRGLAHSSAVMVPIVAGFFLNQDSEFGWRNFFFVLFAINLFGLIIYLVFAKADIQEWARERKLTRL
InterPro domains: - IPR011701: Major facilitator superfamily (family) [104-353]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [99-417]
- IPR050382: Major Facilitator Superfamily Sodium/Anion Cotransporter (family) [105-413]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0022853 (active monoatomic ion transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0015081 (sodium ion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015293 (symporter activity), GO:0015294 (solute:monoatomic cation symporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0015370 (solute:sodium symporter activity), GO:0005436 (sodium:phosphate symporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0006812 (monoatomic cation transport), GO:0006817 (phosphate ion transport), GO:0030001 (metal ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)
Protein: Rubredoxin-like superfamily protein (Q9FI47)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MAMQLPPTTLYAGRSSVVLPPTTPTLQRSSFLPYYSMRLLGNKKSLSKSSAPRFSMRVSSKQAYICRDCGYIYNDRTPFDKLPDNYFCPVCAAPKRRFRAYMPDVSKNVNDKDVRKARKAELQRDEAVGKALPIGIAVGVLALAALYFYVNSTS
InterPro domains: - IPR024935: Rubredoxin domain (domain) [64-98]
- IPR024934: Rubredoxin-like domain (domain) [61-101]
Interaction partners: - Glutaredoxin-C3
- Probable inactive patatin-like protein 9
- Peptide methionine sulfoxide reductase A1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015979 (photosynthesis), GO:0022900 (electron transport chain), GO:0019684 (photosynthesis, light reaction), GO:0009767 (photosynthetic electron transport chain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0043227 (membrane-bounded organelle), GO:0009507 (chloroplast), GO:0042651 (thylakoid membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0031968 (organelle outer membrane), GO:0009579 (thylakoid), GO:0055035 (plastid thylakoid membrane), GO:0009535 (chloroplast thylakoid membrane), GO:0009534 (chloroplast thylakoid)
Protein: Probable histone H2AXb (HTA3) (Q9S9K7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity).
Subcellular location: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Sequence: MSSGAGSGTTKGGRGKPKATKSVSRSSKAGLQFPVGRIARFLKAGKYAERVGAGAPVYLSAVLEYLAAEVLELAGNAARDNKKTRIVPRHIQLAVRNDEELSKLLGSVTIANGGVLPNIHQTLLPSKVGKNKGDIGSASQEF
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [8-135]
- IPR002119: Histone H2A (family) [10-130]
- IPR007125: Histone H2A/H2B/H3 (domain) [15-96]
- IPR032454: Histone H2A, C-terminal domain (domain) [99-132]
- IPR032458: Histone H2A conserved site (conserved_site) [29-35]
Interaction partners: - Histone H4
- ATP-dependent DNA helicase 2 subunit KU80
- Histone H3.1
- ATP-dependent DNA helicase 2 subunit KU70
- DNA repair protein RAD51 homolog 1
- Histone H3.3
- Histone H3-like 5
- Histone H3-like 3
- Histone H3-like 1
- Histone H3-like centromeric protein CENH3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006325 (chromatin organization), GO:0006338 (chromatin remodeling), GO:0070828 (heterochromatin organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Catalase (EC 1.11.1.6) (Q2U962)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Not known
Sequence: MANIVAGGLHKVQEAVQGAASKDKKLVDLAPDTHNVQSSKEPLTTDHGVRISDTDHWLKEVNDNHTGPMMLEDQIAREKIHRFDHERIPERVVHARGTAAFGNFKLHESAEDVSYAGILTDTSRNTPVFLRFSTVQGSKGSADTVRDVRGFAVKFYTDEGNWDLVGNNIPVFFIQDAIKFPDFVHAVKPEPHNEVPQAQTAHNNFWDFVYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFSLINKEGKRHFVKFHFIPHLGVHSLVWDEALKLAGQDPDFHRKDLMEAIDNGAYPKWDFAIQVIPEEKQDDFEFDIFDATKIWPEELVPLRVIGELELNRNVDEFFPQTEQVAFCTSHIVPGIDFSDDPLLQGRNFSYFDTQISRLGINWEEIPINRPVCPVLNHNRDGAKRHRIAQGTVNYWPNRFEAGPPAPVEQGGFASYPAKLNGIKKRGLSPKFREHHNQAQLFYNSLSEHEKVHVKKAFGFELDHCDDPIVYERLAGHRLAEIDLTLAQEVAELVGAPIPDKALRPNHGKRSKHLSQTEFPGKQPTIASRRIAIIIGDGYDPVAFNGLKGAITAVGALPFVIGTKRSPIYADGEDKSSSKGVIADHQYDGQRSTMFDATFIPGGPHVESLKANGQIRYWIIETFGHLKALGATGEAAAFIKEALGSALDVKVATSDNPQPVEWYGVVTAGKIHKPESFKEGIQIVKDAKDFISTFFYQISQHRNYKRELDGLASTVAF
InterPro domains: - IPR029062: Class I glutamine amidotransferase-like (homologous_superfamily) [549-747]
- IPR018028: Catalase, mono-functional, haem-containing (family) [40-530]
- IPR020835: Catalase superfamily (homologous_superfamily) [22-553]
- IPR024712: Catalase, mono-functional, haem-containing, clade 2 (family) [7-742]
- IPR010582: Catalase immune-responsive domain (domain) [459-523]
- IPR011614: Catalase core domain (domain) [44-434]
- IPR002226: Catalase haem-binding site (binding_site) [377-385]
- IPR024708: Catalase active site (active_site) [83-99]
- IPR041399: Large catalase, C-terminal domain (domain) [567-702]
- IPR043156: Catalase, mono-functional, haem-containing, clade 2, helical domain (homologous_superfamily) [455-548]
Interaction partners: - catalase
- Catalase
- catalase
- Oxidase FUB9
- Catalase B
- Catalase
- Oxidase FUB9
- Oxidase FUB9
- Oxidase FUB9
- 3-hydroxyanthranilate 3,4-dioxygenase 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0016209 (antioxidant activity), GO:0003824 (catalytic activity), GO:0004601 (peroxidase activity), GO:0016491 (oxidoreductase activity), GO:0004096 (catalase activity), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0006979 (response to oxidative stress), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0034599 (cellular response to oxidative stress), GO:0042542 (response to hydrogen peroxide), GO:1901701 (cellular response to oxygen-containing compound), GO:0000302 (response to reactive oxygen species), GO:0062197 (cellular response to chemical stress), GO:0034614 (cellular response to reactive oxygen species), GO:0070301 (cellular response to hydrogen peroxide)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Regulator of MON1-CCZ1 complex (Protein Bulli) (Q9VRX1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Late endosome {ECO:0000269|PubMed:32499409}. Note=Colocalizes with Rab7, but not Rab5 positive endosomal structures. {ECO:0000269|PubMed:32499409}.
Sequence: MDNSNGIHYIELTPNPIRFDAVSQLTNVFFDDSNKQIFAVRSGGATGVVVKGPGSPDDVVISFCMSDRGGAIRSIKFSPDNQILAVQRKENSVEFICFQGDQPLLQDIITHQVKTLIHGFVWVHNREVALISNTGVEVYTVVPEKRQVRSVKSLSIGIKWFAWCCDANVALLCTSEGNSLIPVLVKQKVITKLPKVDLGNPSRDVQESKVTLGQVYGVLAVLILQSNSTTGLMEVEVHLLNGPGLAPRKCHVLRLSLLGRFAINTVDNLIVVHHQASGTSLLFDISLPGEVINEITYHTPITPGRSIKPFGLKLPSLSPDGQILQCELYSTHWVLFQPNIVIDAKLGCMWFLNLCIEPLCQLISDRIRLTEFLLQRSNGKQMLLKVIGQLVDDQYKGTLLPVLETIFSRINKIYASWVQLELQNQTAQPSNVKTTTLKQSTPPIVLIEQLDMVQIFQRIARRPYTESILMLYLQSLNKFNIAAQEELSKMIISELISNRSFDTLRRLVSYSMLLESKSVACFLLSHSNVDTAISQVAIDMLGRIEAHEIIIEVMLGQGKVIDALRLAKNSMGLEKVPARKFLEAAHKTKDDLIFHSVYRFFQMRNLKLYETLSFPKAEQCTEFIQHYNNTFPADNPTRQPVS
InterPro domains: - IPR049040: Regulator of MON1-CCZ1 complex, N-terminal (domain) [28-147]
- IPR040371: Regulator of MON1-CCZ1 complex (family) [7-619]
- IPR009755: Regulator of MON1-CCZ1 complex, C-terminal (domain) [376-616]
Interaction partners: - Vacuolar fusion protein CCZ1 homolog
- Vacuolar fusion protein MON1 homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0010506 (regulation of autophagy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0005773 (vacuole), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005770 (late endosome), GO:0005774 (vacuolar membrane), GO:0010008 (endosome membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0031902 (late endosome membrane), GO:0098852 (lytic vacuole membrane), GO:0005765 (lysosomal membrane)
Protein: Eukaryotic translation initiation factor 4E, putative (Q387Q8)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MQTLLRPRPGEPTLFGPPTNQCTQLWGVWEMWCVLPDGHEAATATPNVRGSGAKKGGMSKTKVKKATWLDQVRSIGLFDSAEGFWGIITCTLNPSQLPPGFNYYLFRRNIAPMWEHEANRRGGRWVMRFRVSQHDDSPATALDGAVAAAAEGQLPVDRAWEALCVAMIGEQLPGDETEICGAVVRRAERRRDWKLSLWTRTAADRCTQERIGFFVKDLLHLEDGSLQYFSHRELMQASEKGNWDVPPLYQL
InterPro domains: - IPR023398: Translation Initiation factor eIF- 4e-like (homologous_superfamily) [16-243]
- IPR001040: Translation Initiation factor eIF- 4e (family) [25-233]
Interaction partners: - Eukaryotic translation initiation factor 4E, putative
- Probable eukaryotic initiation factor 4A
- Polyadenylate-binding protein
- MIF4G domain-containing protein
- MIF4G domain-containing protein
- MIF4G domain-containing protein
- MIF4G domain-containing protein
- MIF4G domain-containing protein
- Polyadenylate-binding protein
- Elongation initiation factor 2 alpha subunit, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0000339 (RNA cap binding), GO:0000340 (RNA 7-methylguanosine cap binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Periphilin 1 (F8VWU8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MWSEGRYEYERIPRERAPPRSHPSDGYNRLVNIVPKKPPLLDRPGEGSYNRYYSHVDYRDYDEGRSFSHDRRSGPPHRGDESGYRWTRDDHSASRQPEYRDMRDGFRRKSFYSSHYARERSPYKRDNTFFRESPVGRKDSPHSRSGSSVSSRSYSPERSKSYSFHQSQ
InterPro domains: - IPR028851: Periphilin-1 (family) [1-168]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0043484 (regulation of RNA splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Variant surface glycoprotein (VSG, atypical), putative (Q380W2)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}.
Sequence: MHTTTAAALILTLTAAMQRHASATAGDVVKGASWTPLCSITADSEKLAANLLQNLIQNARDGETALQRLLRALVYNEATGGQPLSNATMAVWSLYAEVAGRAAARIQQTEAKAVVTAARNIGRLQGAISEFLESQADASADNKGCLQAAAGTTAVIVGKQQLYREQPTCKMSWDEVKNEKTTTSVITATGIKHTNSGGQENGQTIHSGQGTDCDISQPQSSFKLTYGSRGNDVAGHVPKLAAGYFTVDATGFKIPKHDTLQDATTASPYLGKAIEAVTAVPAKEAATSIKTIAELKAHQDFKGPARRYLLGKKLTETDGDTQLEEKITNAYVNDDNAKKALFEAVDAYQIHDNLRPSPADDTLGKITSIHILMHLYFHYRSAREQAIQNRMQKLQEKAKHASDTISTEEKEKECNTKGKDDEEACKKLAKDGCVFNPKGNEGKKCELKKEVKAEPEKEKENEEKDKKTDSKCTGKEQKDCEKAPECKLENNACKNSIFLVNKKPVLMADAFADL
InterPro domains: - IPR019609: Trypanosome variant surface glycoprotein, C-terminal (domain) [414-514]
- IPR027446: Variant surface glycoprotein C-terminal domain superfamily (homologous_superfamily) [409-468]
- IPR001812: Trypanosome variant surface glycoprotein, A-type, N-terminal domain (domain) [10-379]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051701 (biological process involved in interaction with host), GO:0075136 (response to host), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0052200 (response to host defenses), GO:0052572 (response to host immune response), GO:0042783 (evasion of host immune response), GO:0020033 (antigenic variation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)