Protein: Haptoglobin-related protein (P00739)
Organism: Homo sapiens (Human)
Function: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Subcellular location: Secreted {ECO:0000269|PubMed:16778136}. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL). {ECO:0000269|PubMed:16778136}.
Sequence: MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN
InterPro domains: - IPR008292: Haptoglobin (family) [1-348]
- IPR043504: Peptidase S1, PA clan, chymotrypsin-like fold (homologous_superfamily) [106-342]
- IPR001314: Peptidase S1A, chymotrypsin family (family) [130-302]
- IPR035976: Sushi/SCR/CCP superfamily (homologous_superfamily) [36-96]
- IPR009003: Peptidase S1, PA clan (homologous_superfamily) [80-347]
- IPR001254: Serine proteases, trypsin domain (domain) [103-346]
Interaction partners: - Apolipoprotein L1
- Apolipoprotein A-I
- Haptoglobin
- Serum paraoxonase/arylesterase 1
- Hemoglobin subunit alpha
- Hemoglobin subunit beta
- Apolipoprotein A-II
- Beta-2-glycoprotein 1
- Scavenger receptor cysteine-rich type 1 protein M130
- Apolipoprotein C-I
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0050790 (regulation of catalytic activity), GO:0010942 (positive regulation of cell death), GO:0010035 (response to inorganic substance), GO:0010941 (regulation of cell death), GO:0006979 (response to oxidative stress), GO:0044092 (negative regulation of molecular function), GO:0006952 (defense response), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0051341 (regulation of oxidoreductase activity), GO:0043086 (negative regulation of catalytic activity), GO:0010310 (regulation of hydrogen peroxide metabolic process), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:2000378 (negative regulation of reactive oxygen species metabolic process), GO:0031330 (negative regulation of cellular catabolic process), GO:0042542 (response to hydrogen peroxide), GO:0031329 (regulation of cellular catabolic process), GO:0000302 (response to reactive oxygen species), GO:0051354 (negative regulation of oxidoreductase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0072562 (blood microparticle), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)