Protein: Mannose-1-phosphate guanyltransferase (EC 2.7.7.13) (GDP-mannose pyrophosphorylase) (GTP-mannose-1-phosphate guanylyltransferase) (Q4U3E8)
Organism: Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata)
Function: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).
Subcellular location: Cytoplasm {ECO:0000250}.
Sequence: MKALILVGGFGTRLRPLTLTLPKPLVEFGNRPMILHQVESLAAAGVTDIVLAVNYRPDVMVAALKKYEEQYNVRIEFSVESEPLGTAGPLKLAEKILGKDDSPFFVLNSDIICDYPFKQLAEFHKKHGDEGTIVVTKVDEPSKYGVVVHKPNHPSRIDRFVEKPVEFVGNRINAGIYILNPSVLKRIELRPTSIEQETFPAICSDGQLHSFDLEGFWMDVGQPKDFLTGTCLYLTSLAKRNSKLLAPNSEPYVYGGNVMVDPSAKIGKNCRIGPNVVIGPNVVVGDGVRLQRCVLLENSKVKDHAWIKSTIVGWNSSVGKWARLENVTVLGDDVTIADEVYVNGGSILPHKSIKQNIDVPAIIM
InterPro domains: - IPR018357: Hexapeptide transferase, conserved site (conserved_site) [260-340]
- IPR056729: Mannose-1-phosphate guanyltransferase, C-terminal domain (domain) [256-363]
- IPR050486: Mannose-1-phosphate guanyltransferase (family) [1-364]
- IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [1-315]
- IPR045233: Mannose-1-phosphate guanyltransferase, N-terminal domain (domain) [1-234]
- IPR005835: Nucleotidyl transferase domain (domain) [2-233]
Interaction partners: - Mannose-1-phosphate guanyltransferase
- Phosphomannomutase
- GDP-mannose 4,6-dehydratase
- Phosphoglucomutase, putative
- Chitobiosyldiphosphodolichol beta-mannosyltransferase
- Dolichol-phosphate mannosyltransferase subunit 1
- NUDIX family hydrolase, putative
- Dolichol phosphate-mannose biosynthesis regulatory protein
- Eukaryotic translation initiation factor 2 subunit alpha
- Translational initiation factor 2 beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070568 (guanylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071554 (cell wall organization or biogenesis), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044036 (cell wall macromolecule metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0042546 (cell wall biogenesis), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009100 (glycoprotein metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0070589 (cellular component macromolecule biosynthetic process), GO:0009225 (nucleotide-sugar metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0044038 (cell wall macromolecule biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019673 (GDP-mannose metabolic process), GO:0009101 (glycoprotein biosynthetic process), GO:0006056 (mannoprotein metabolic process), GO:0009226 (nucleotide-sugar biosynthetic process), GO:0031506 (cell wall glycoprotein biosynthetic process), GO:0006057 (mannoprotein biosynthetic process), GO:0000032 (cell wall mannoprotein biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)