Protein: Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics) (Q5PR69)
Organism: Mus musculus (Mouse)
Function: Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity).
Subcellular location: Cytoplasm, cytosol {ECO:0000305|PubMed:30361697}.
Sequence: MGARAFSHDSIFIPDGGAESEQTVQAMSQDNILGKVKTLQRQLGKNIKFGQRPSNAIPMKKAGSTDASSEEDFVLTSPMEIVTQQDIVPSDTENKSSDTPSSSSPLNLPEAGSDMEEKVAPVKPSRPKRHLSSAGTIESVNLDAIPLAIARLDNSAARHKLAVKPKNQRVSRKHRWLAQDRQNEPGSFESQSSLDQNGQLGEDKHIWHGEEPEPLESHEEKRLHEEYWRELEAKCKRQKAEAAEKRRQEEQRRQALERRLWEESLRQELLEEEEEGEEEEEVKEEGEEGEEVGLQPRAGKVPPEEGHQSGPEEQRCTEQELGGADDPARLEAEERRREQEEAERQAEKLRQREAERQEEEQKQREAERQEEEARQCEAERQAEKLRQREAERQEEEARQREAERQAEKLRQREAERQEEELRQREEAERQEKLRQRDAESQEEELRQREAERQRAQEEDAKGMLQEEEEEAKRIEELKGKETPEPLVEEGPQSPEGESQPWLTDDADQRSPLQRDLEKPGEREREDLESAGQREIAEEPRGEGEPAEQSGDLDAHCGGVDGEGKETAQTDSPQPQERQMEGTPAPEENEATAADIDRKVEELRWQEVDERQTMPRPYTFQVSSGSRQILFPKVNLSPVTPAKDASLAPAAQEPPAPRGAASHALPSALSIPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLSEEKRPMDVPTVESRAGSGKSRPAPESPSNAAALAEWASIRSRILKNSEGDQRGDREPARAGDEPVPRARCDSRGNVRRTPPVNAKFSIMPAWQKFSDSGAETFRQSLDGESGRKKPGLAPSEETAPQPHAAAQQEVSQEPPDTTDGCKFAKDLPSFLVPGLPSPQKAASRTESTTTLDSETTSDVGNPDPAMPGGEEKASPFGIKLRRTNYSLRFHCDQQAEQKKKKRHSSTGDSVGGATPATGSVSGESEPEATFLKHGPSLPQERKPALSPRKDSAESHSSGHYVAVAQSGLPPASGQTPAPEQDRAVSKMPSMQKPALAPKPASQTPPSSPLSKLSRPHLVELLARRAGKLDSEPSETAKESSDNQPPSPSLPEELKGQKRDEKDVPEKKPASPPLPAGQQERPSLIPETGRKEKPVLQSRHSLDGSKVTEKVETAQPLWITLALQKQKGFREQQATREERKQAREAKQAEKLSKETVSVSLQPGSSRASKTAPVHKPAAPSEEKKPETAVSRLQRREQLKKSNTLPTSVTVEISDSAPSAALVKDVTKRFSTPDAAPVSTEPAWLALAKRKAKAWSDCPQIIK
InterPro domains: - IPR052853: Actin dynamics regulator (family) [1-1291]
- IPR028030: Domain of unknown function DUF4592 (domain) [45-173]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030029 (actin filament-based process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0051129 (negative regulation of cellular component organization), GO:0035148 (tube formation), GO:0035556 (intracellular signal transduction), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0030036 (actin cytoskeleton organization), GO:0032970 (regulation of actin filament-based process), GO:0044087 (regulation of cellular component biogenesis), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0051128 (regulation of cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0090066 (regulation of anatomical structure size), GO:0035239 (tube morphogenesis), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:0060562 (epithelial tube morphogenesis), GO:0021915 (neural tube development), GO:0055001 (muscle cell development), GO:0043244 (regulation of protein-containing complex disassembly), GO:0032956 (regulation of actin cytoskeleton organization), GO:0002009 (morphogenesis of an epithelium), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0016331 (morphogenesis of embryonic epithelium), GO:0072175 (epithelial tube formation), GO:0022607 (cellular component assembly), GO:0031333 (negative regulation of protein-containing complex assembly), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0043242 (negative regulation of protein-containing complex disassembly), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0060606 (tube closure), GO:0033043 (regulation of organelle organization), GO:0043933 (protein-containing complex organization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0031032 (actomyosin structure organization), GO:0097435 (supramolecular fiber organization), GO:0009792 (embryo development ending in birth or egg hatching), GO:0007015 (actin filament organization), GO:0032272 (negative regulation of protein polymerization), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0030835 (negative regulation of actin filament depolymerization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:1901879 (regulation of protein depolymerization), GO:0032271 (regulation of protein polymerization), GO:0065003 (protein-containing complex assembly), GO:0030832 (regulation of actin filament length), GO:0030832 (regulation of actin filament length), GO:0008154 (actin polymerization or depolymerization), GO:1901880 (negative regulation of protein depolymerization), GO:0045214 (sarcomere organization), GO:0001843 (neural tube closure), GO:0007010 (cytoskeleton organization), GO:0001841 (neural tube formation), GO:0032984 (protein-containing complex disassembly), GO:0110053 (regulation of actin filament organization), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0051693 (actin filament capping), GO:0030834 (regulation of actin filament depolymerization), GO:0030833 (regulation of actin filament polymerization), GO:0014020 (primary neural tube formation), GO:0030042 (actin filament depolymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)