Protein: Protein bric-a-brac 1 (Q9W0K7)
Organism: Drosophila melanogaster (Fruit fly)
Function: Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320, ECO:0000269|PubMed:11973274}.
Sequence: MASAQAETNVGLASEQGPVAQRQRKGTGSGADSPKSNRSSPTQQEEKRIKSEDRTSPTGGAKDEDKESQGHAVAGGGGSSPVSSPQGRSSSVASPSSSSQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQHPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHMEAATAAAAAASSERMPSSPKESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIFNPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHALDMPSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSAHHPASPAGDSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGGGAGGVGSGGGSSLADDLEIKPGIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQSMWQKCWNTNQNLMHHMRFRERGPLKSWRPETMAEAIFSVLKEGLSLSQAARKYDIPYPTFVLYANRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVFRDTKDIKDESLAAHMPPYGRHSPAFPLQDLPLSYPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHMSQETAAAVAAVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGGRASISPALSSGSGPRHAPSPCGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQLHLQQQQAHLHHHQQQQQQQQQQHHQGGHQVAHKSGFGASSSSSASSSSMGQHHAPKAKSSPLRSETPRLHSPLGDLGLDMASYKREFSPSRLFAEDLAELVGASVSSSSSSAAAATAPPERSAGAASAATGADAPSSSSSGGIKVEPITTTSE
InterPro domains: - IPR009057: Homedomain-like superfamily (homologous_superfamily) [563-613]
- IPR000210: BTB/POZ domain (domain) [117-222]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [100-256]
- IPR051095: Drosophila Developmental Transcription Regulators (family) [99-888]
- IPR007889: DNA binding HTH domain, Psq-type (domain) [559-612]
Interaction partners: - TBP-associated factor 3
- Protein doublesex
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0008037 (cell recognition), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0071684 (organism emergence from protective structure), GO:0009056 (catabolic process), GO:0044237 (cellular metabolic process), GO:0098727 (maintenance of cell number), GO:0065009 (regulation of molecular function), GO:0019827 (stem cell population maintenance), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0008038 (neuron recognition), GO:0051129 (negative regulation of cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0045137 (development of primary sexual characteristics), GO:0010453 (regulation of cell fate commitment), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0007548 (sex differentiation), GO:0009886 (post-embryonic animal morphogenesis), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0007283 (spermatogenesis), GO:0045165 (cell fate commitment), GO:0061061 (muscle structure development), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0016358 (dendrite development), GO:0045596 (negative regulation of cell differentiation), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0046661 (male sex differentiation), GO:0097305 (response to alcohol), GO:0030030 (cell projection organization), GO:1901654 (response to ketone), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0032990 (cell part morphogenesis), GO:0048707 (instar larval or pupal morphogenesis), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0008406 (gonad development), GO:0046546 (development of primary male sexual characteristics), GO:0035272 (exocrine system development), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0007526 (larval somatic muscle development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0007292 (female gamete generation), GO:0002064 (epithelial cell development), GO:0048813 (dendrite morphogenesis), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0048858 (cell projection morphogenesis), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:0061458 (reproductive system development), GO:0035282 (segmentation), GO:0031344 (regulation of cell projection organization), GO:0048663 (neuron fate commitment), GO:0055001 (muscle cell development), GO:0060284 (regulation of cell development), GO:0007423 (sensory organ development), GO:0048477 (oogenesis), GO:0048806 (genitalia development), GO:0030539 (male genitalia development), GO:0051960 (regulation of nervous system development), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0042659 (regulation of cell fate specification), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0031345 (negative regulation of cell projection organization), GO:0060429 (epithelium development), GO:0048232 (male gamete generation), GO:0051253 (negative regulation of RNA metabolic process), GO:0030182 (neuron differentiation), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0042981 (regulation of apoptotic process), GO:0048592 (eye morphogenesis), GO:0045471 (response to ethanol), GO:2001141 (regulation of RNA biosynthetic process), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0150063 (visual system development), GO:0042461 (photoreceptor cell development), GO:0007411 (axon guidance), GO:0009411 (response to UV), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0048699 (generation of neurons), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0097306 (cellular response to alcohol), GO:1901655 (cellular response to ketone), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0001654 (eye development), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0001700 (embryonic development via the syncytial blastoderm), GO:0046530 (photoreceptor cell differentiation), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006355 (regulation of DNA-templated transcription), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0035220 (wing disc development), GO:0031175 (neuron projection development), GO:0048812 (neuron projection morphogenesis), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0071390 (cellular response to ecdysone), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0042462 (eye photoreceptor cell development), GO:0010975 (regulation of neuron projection development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0048749 (compound eye development), GO:0001745 (compound eye morphogenesis), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0001754 (eye photoreceptor cell differentiation), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0001751 (compound eye photoreceptor cell differentiation), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0042051 (compound eye photoreceptor development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031519 (PcG protein complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)