wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: protein-serine/threonine phosphatase (EC 3.1.3.16) (Q59PS6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Not known
Sequence: MGQLLSHPIEEKELDYKSYTNLTYCIGSMQGYRMTMEDAHDVKINEHENLAVFGIFDGHGGKNCSQYLAEHLPKLVFTKLNKIASAVYLKQVKDIDLKDVFDILKNSFFKIDKDLSHHANMVNCGSTATVVTIIANYIVVANTGDSRCIVSRNGHAKPLSFDHKPSNMGERVRIENSNGYILNNRINEVLALSRAFGDFKFKLPYLSSSRNKYIKENQKLLGDKLITLPPELFQVTVEPDIMLYDMQKLDSPEFLVIACDGVWDCFKNGQLVKLIRDKLSLGWRLNKIVEYILNDSLTMANNYTGIGFDNMTLIIVAIHKKEGETMDDWYESMKEKILKEKGITR
InterPro domains: - IPR036457: PPM-type phosphatase-like domain superfamily (homologous_superfamily) [1-327]
- IPR000222: PPM-type phosphatase, divalent cation binding (binding_site) [52-60]
- IPR015655: Protein phosphatase 2C (family) [27-315]
- IPR001932: PPM-type phosphatase-like domain (domain) [13-318]
Interaction partners: - N-acetyltransferase domain-containing protein
- Polyamine acetyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: Metallothionein-like protein 4C (Class I metallothionein-like protein 4C) (MT-1-4b) (OsMT-I-4c) (OsMT1c) (Q2QNC3)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Acts as reactive oxygen species (ROS) scavenger. Possesses superoxide anion and hydroxyl radical scavenging activities in vitro. Involved in ROS homeostasis during anther and pollen development.
Sequence: MSCGGSCNCGSCGCGGGCGKMYPDLAEKITTTTTTATTVLGVAPEKGHSEGVGKAAESGEAAHGCSCGSSCRCNPCNC
InterPro domains: - IPR000347: Metallothionein, family 15, plant (family) [1-78]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0016151 (nickel cation binding), GO:0046870 (cadmium ion binding), GO:0005507 (copper ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006970 (response to osmotic stress), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0097305 (response to alcohol), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid), GO:0042542 (response to hydrogen peroxide), GO:0033993 (response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: High-affinity choline transporter 1 (O02228)
Organism: Caenorhabditis elegans
Function: Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MADLLGIVAIVFFYVLILVVGIWAGRKSKSSKELESEAGAATEEVMLAGRNIGTLVGIFTMTATWVGGAYINGTAEALYNGGLLGCQAPVGYAISLVMGGLLFAKKMREEGYITMLDPFQHKYGQRIGGLMYVPALLGETFWTAAILSALGATLSVILGIDMNASVTLSACIAVFYTFTGGYYAVAYTDVVQLFCIFVGLWVCVPAAMVHDGAKDISRNAGDWIGEIGGFKETSLWIDCMLLLVFGGIPWQVYFQRVLSSKTAHGAQTLSFVAGVGCILMAIPPALIGAIARNTDWRMTDYSPWNNGTKVESIPPDKRNMVVPLVFQYLTPRWVAFIGLGAVSAAVMSSADSSVLSAASMFAHNIWKLTIRPHASEKEVIIVMRIAIICVGIMATIMALTIQSIYGLWYLCADLVYVILFPQLLCVVYMPRSNTYGSLAGYAVGLVLRLIGGEPLVSLPAFFHYPMYTDGVQYFPFRTTAMLSSMATIYIVSIQSEKLFKSGRLSPEWDVMGCVVNIPIDHVPLPSDVSFAVSSETLNMKAPNGTPAPVHPNQQPSDENTLLHPYSDQSYYSTNSN
InterPro domains: - IPR052244: High-affinity choline transporter (family) [2-539]
- IPR038377: Sodium/glucose symporter superfamily (homologous_superfamily) [37-515]
- IPR001734: Sodium/solute symporter (family) [3-458]
Interaction partners: - Vesicular acetylcholine transporter unc-17
- Proline dehydrogenase 1, mitochondrial
- Choline O-acetyltransferase
- Transcription factor unc-3
- LIM/homeobox protein lim-6
- Probable vesicular glutamate transporter eat-4
- Probable delta-1-pyrroline-5-carboxylate synthase
- GLutamate Receptor family
- Soluble guanylate cyclase gcy-33
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015101 (organic cation transmembrane transporter activity), GO:0005326 (neurotransmitter transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015651 (quaternary ammonium group transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015695 (organic cation transport), GO:0015697 (quaternary ammonium group transport), GO:0072337 (modified amino acid transport), GO:0015838 (amino-acid betaine transport), GO:0015879 (carnitine transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Homeobox protein MSH-C (Q01703)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Involved in the development of the inner ear.
Subcellular location: Nucleus.
Sequence: MAPLSSMMNSLQGPLSQEGKLQERKSDKEDAQSNDKAAVKGCKGKALSLPFSVESLISDRTSSRTLYTSSEAGIISPTSGADERLKLSPMALYADRKIPVESVSNLSDCKRGDMEELSDKGQSGWFQTTSYTSPPRHSSPPPCTLRKHKNNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSNSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKLATKPLLPAFAFPFPLGTHVGSPPLYGPSSSFPRPALPVPGLFGGPVTYGMYYLS
InterPro domains: - IPR001356: Homeodomain (domain) [149-213]
- IPR050674: Msh Homeobox Transcriptional Regulators (family) [21-273]
- IPR020479: Homeodomain, metazoa (domain) [173-207]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [130-210]
- IPR017970: Homeobox, conserved site (conserved_site) [184-207]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0009888 (tissue development), GO:0048513 (animal organ development), GO:0060788 (ectodermal placode formation), GO:0009790 (embryo development), GO:0048839 (inner ear development), GO:0071696 (ectodermal placode development), GO:0071697 (ectodermal placode morphogenesis), GO:0035239 (tube morphogenesis), GO:0071599 (otic vesicle development), GO:0060562 (epithelial tube morphogenesis), GO:0048568 (embryonic organ development), GO:0042472 (inner ear morphogenesis), GO:0048562 (embryonic organ morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0043049 (otic placode formation), GO:0060429 (epithelium development), GO:0072175 (epithelial tube formation), GO:0071600 (otic vesicle morphogenesis), GO:0042471 (ear morphogenesis), GO:0043583 (ear development), GO:0030916 (otic vesicle formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Petal death protein (EC 3.7.1.1) ((R)-2-methylmalate lyase) (D-citramalate lyase) (EC 4.1.3.-) (Oxalacetic hydrolase) (PSR132) (Q05957)
Organism: Dianthus caryophyllus (Carnation) (Clove pink)
Function: Catalyzes cleavage of the C(2)-C(3) bond in oxaloacetate and in (2R)-alkyl malate derivatives to form oxalate and acetate, and alkyl carboxylates and R-ketocarboxylates, respectively.
Sequence: MAPPNGTTNGETEVATQGSYTAVSTGRKTTMHRLIEEHGSVLMPGVQDALSAAVVEKTGFHAAFVSGYSVSAAMLGLPDFGLLTTTEVVEATRRITAAAPNLCVVVDGDTGGGGPLNVQRFIRELISAGAKGVFLEDQVWPKKCGHMRGKAVVPAEEHALKIAAAREAIGDSDFFLVARTDARAPHGLEEGIRRANLYKEAGADATFVEAPANVDELKEVSAKTKGLRIANMIEGGKTPLHTPEEFKEMGFHLIAHSLTAVYATARALVNIMKILKEKGTTRDDLDQMATFSEFNELISLESWYEMESKFKNFTPKAT
InterPro domains: - IPR040442: Pyruvate kinase-like domain superfamily (homologous_superfamily) [28-318]
- IPR018523: Isocitrate lyase/phosphorylmutase, conserved site (conserved_site) [142-147]
- IPR039556: ICL/PEPM domain (domain) [31-273]
- IPR015813: Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (homologous_superfamily) [26-313]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016833 (oxo-acid-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0006629 (lipid metabolic process), GO:0044282 (small molecule catabolic process), GO:1901575 (organic substance catabolic process), GO:0019541 (propionate metabolic process), GO:0044248 (cellular catabolic process), GO:0006082 (organic acid metabolic process), GO:0019543 (propionate catabolic process), GO:0006631 (fatty acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0044242 (cellular lipid catabolic process), GO:0043436 (oxoacid metabolic process), GO:0016042 (lipid catabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0046459 (short-chain fatty acid metabolic process), GO:0009062 (fatty acid catabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0019626 (short-chain fatty acid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Tubulin alpha 1c (F8VS66)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
Sequence: MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLVSIVL
InterPro domains: - IPR000217: Tubulin (family) [2-130]
- IPR002452: Alpha tubulin (family) [18-128]
- IPR036525: Tubulin/FtsZ, GTPase domain superfamily (homologous_superfamily) [1-128]
- IPR003008: Tubulin/FtsZ, GTPase domain (domain) [3-126]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0007017 (microtubule-based process), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0008104 (protein localization), GO:0007399 (nervous system development), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization), GO:0033365 (protein localization to organelle), GO:0034504 (protein localization to nucleus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: UDP-glycosyltransferase 73C11 (EC 2.4.1.368) (Oleanolate 3-O-glucosyltransferase UGT73C11) (K4GGT4)
Organism: Barbarea vulgaris (Yellow rocket) (Erysimum barbarea)
Function: Catalyzes the transfer of a glucose (Glc) moiety from UDP-Glc to the C-3 position of the oleanane sapogenins oleanolate and hederagenin, and to the C-28 carboxylic group of the lupane sapogenin betulinate. The monoglucosylated hederagenin 3-O-beta-D-glucoside is a feeding deterrent of the yellow-striped flea beetle (Phyllotreta nemorum).
Sequence: MVSEITHKSYPLHFVLFPFMAQGHMIPMVDIARLLAQRGVKITIVTTPHNAARFENVLSRAIESGLPISIVQVKLPSQEAGLPEGNETFDSLVSMELLVPFFKAVNMLEEPVQKLFEEMSPQPSCIISDFCLPYTSKIAKKFNIPKILFHGMCCFCLLCMHVLRKNREILENLKSDKEHFVVPYFPDRVEFTRPQVPMATYVPGEWHEIKEDIVEADKTSYGVIVNTYQELEPAYANDYKEARSGKAWTIGPVSLCNKVGADKAERGNKADIDQDECLKWLDSKEEGSVLYVCLGSICSLPLSQLKELGLGLEESQRPFIWVVRGWEKNKELLEWFSESGFEERVKDRGLLIKGWSPQMLILAHHSVGGFLTHCGWNSTLEGITSGIPLLTWPLFGDQFCNQKLVVQVLKVGVSAGVEEVTNWGEEEKIGVLVDKEGVKKAVEELMGESDDAKERRKRVKELGQLAQKAVEEGGSSHSNITSLLEDIMQLAQSNN
InterPro domains: - IPR002213: UDP-glucuronosyl/UDP-glucosyltransferase (family) [12-479]
- IPR035595: UDP-glycosyltransferase family, conserved site (conserved_site) [355-398]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901657 (glycosyl compound metabolic process), GO:0016137 (glycoside metabolic process), GO:0016134 (saponin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cyclase (O53866)
Organism: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Function: Not known
Sequence: MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPSKVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNTLVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ
InterPro domains: - IPR019587: Polyketide cyclase/dehydrase (family) [6-140]
- IPR023393: START-like domain superfamily (homologous_superfamily) [1-146]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0005515 (protein binding), GO:0005319 (lipid transporter activity), GO:0005548 (phospholipid transporter activity), GO:0120013 (lipid transfer activity), GO:0120014 (phospholipid transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0009628 (response to abiotic stimulus), GO:0070482 (response to oxygen levels), GO:0001666 (response to hypoxia), GO:0036293 (response to decreased oxygen levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Chromo domain-containing protein (Q54RN0)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGKRDKRIIEEPEEPEEAGDVFEVEKILDKRVQHGRIQYSIRWKGFTADYDTWEDEDNVAGCPELVKEFESSREQEKKKSRKRKNVIVNDDQTAVESSSPPPTTKPSSSSSSTKTTKAATSTTTNTSTQQKTNHLIDDEEYIKNEYIKFGVPYIEGIGFENGHCVEEIIGCKPFGQDNTLFFFVKWRGQEKLSWVLNEILKHKEPLQLIEFYENRLKFGYKGQQS
InterPro domains: - IPR017984: Chromo domain subgroup (domain) [19-59]
- IPR023780: Chromo domain (domain) [22-71]
- IPR000953: Chromo/chromo shadow domain (domain) [21-217]
- IPR051219: Heterochromatin-associated chromo domain-containing protein (family) [1-217]
- IPR008251: Chromo shadow domain (domain) [157-221]
- IPR016197: Chromo-like domain superfamily (homologous_superfamily) [8-220]
- IPR023779: Chromo domain, conserved site (conserved_site) [39-59]
Interaction partners: - RNA helicase
- Origin recognition complex subunit 2
- DNA
- Histone H3.3 type a
- Histone H3.3 type c
- Histone H3.3 type b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0003677 (DNA binding), GO:0003723 (RNA binding), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098687 (chromosomal region), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0000792 (heterochromatin), GO:0000775 (chromosome, centromeric region), GO:0043228 (non-membrane-bounded organelle), GO:0005721 (pericentric heterochromatin), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)
Protein: Growth arrest and DNA damage-inducible protein GADD45 beta (Myeloid differentiation primary response protein MyD118) (Negative growth regulatory protein MyD118) (P22339)
Organism: Mus musculus (Mouse)
Function: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity).
Sequence: MTLEELVASDNAVQKMQAVTAAVEQLLVAAQRQDRLTVGVYEAAKLMNVDPDSVVLCLLAIDEEEEDDIALQIHFTLIQSFCCDNDIDIVRVSGMQRLAQLLGEPAETLGTTEARDLHCLLVTNCHTDSWKSQGLVEVASYCEESRGNNQWVPYISLEER
InterPro domains: - IPR004038: Ribosomal protein eL8/eL30/eS12/Gadd45 (domain) [22-119]
- IPR029064: Ribosomal protein eL30-like superfamily (homologous_superfamily) [1-160]
- IPR024824: Growth arrest and DNA damage-inducible protein GADD45 (family) [1-160]
Interaction partners: - Mitogen-activated protein kinase kinase kinase 4
- Cyclin-dependent kinase 1
- Cellular tumor antigen p53
- G2/mitotic-specific cyclin-B1
- Growth arrest and DNA damage-inducible protein GADD45 alpha
- Growth arrest and DNA damage-inducible protein GADD45 gamma
- G2/mitotic-specific cyclin-B2
- Proliferating cell nuclear antigen
- G2/mitotic-specific cyclin-B3
- Dual specificity mitogen-activated protein kinase kinase 7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007389 (pattern specification process), GO:0009790 (embryo development), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0035282 (segmentation), GO:0061053 (somite development), GO:0060429 (epithelium development), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)