Protein: CMRF35-like molecule 5 (CLM-5) (CD300 antigen-like family member D) (CMRF35-A4) (CD antigen CD300d) (Q6UXZ3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000269|PubMed:22291008}; Single-pass type I membrane protein {ECO:0000269|PubMed:22291008}. Note=Cell surface localization requires the ITAM-bearing Fc receptor FCER1G to overcome ER retention.
Sequence: MWLSPSLLLLILPGYSIAAKITGPTTVNGSEQGSLTVQCAYGSGWETYLKWRCQGADWNYCNILVKTNGSEQEVKKNRVSIRDNQKNHVFTVTMENLKRDDADSYWCGTERPGIDLGVKVQVTINPGTQTAVSEWTTTTASLAFTAAATQKTSSPLTRSPLKSTHFLFLFLLELPLLLSMLGTVLWVNRPQRRS
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [23-123]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [22-128]
- IPR050671: CD300 family immune receptors (family) [1-180]
- IPR007110: Immunoglobulin-like domain (domain) [13-125]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [17-139]
- IPR003599: Immunoglobulin domain subtype (domain) [24-125]
Interaction partners: - CMRF35-like molecule 1
- CMRF35-like molecule 7
- High affinity immunoglobulin epsilon receptor subunit gamma
- Junctional adhesion molecule A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042221 (response to chemical), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0002682 (regulation of immune system process), GO:0048522 (positive regulation of cellular process), GO:0031341 (regulation of cell killing), GO:0010942 (positive regulation of cell death), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0010941 (regulation of cell death), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0031343 (positive regulation of cell killing), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:1901700 (response to oxygen-containing compound), GO:0031349 (positive regulation of defense response), GO:0002699 (positive regulation of immune effector process), GO:0010033 (response to organic substance), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0002703 (regulation of leukocyte mediated immunity), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0043067 (regulation of programmed cell death), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0043068 (positive regulation of programmed cell death), GO:0001910 (regulation of leukocyte mediated cytotoxicity), GO:0043068 (positive regulation of programmed cell death), GO:0014070 (response to organic cyclic compound), GO:0001912 (positive regulation of leukocyte mediated cytotoxicity), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0002706 (regulation of lymphocyte mediated immunity), GO:0042269 (regulation of natural killer cell mediated cytotoxicity), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0045954 (positive regulation of natural killer cell mediated cytotoxicity), GO:0002717 (positive regulation of natural killer cell mediated immunity), GO:0002715 (regulation of natural killer cell mediated immunity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)