Protein: Envelopment polyprotein (M polyprotein) [Cleaved into: Mucin-like variable region; GP38; Glycoprotein N (Gn) (37 kDa protein) (Glycoprotein G2); Non-Structural protein M (NSm) (15 kDa protein); Glycoprotein C (Gc) (75 kDa protein) (Glycoprotein G1)] (Q8JSZ3)
Organism: Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Function: Glycoprotein N and glycoprotein C interact with each other and are present at the surface of the virion (Probable). Glycoprotein N probably locks the Gn-Gc complex in a prefusion state. Glycoprotein N and glycoprotein C are able to attach the virion to host cell receptors (Probable). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis.
Subcellular location: [Envelopment polyprotein]: Host endoplasmic reticulum membrane {ECO:0000269|Ref.2}.; SUBCELLULAR LOCATION: [Glycoprotein N]: Virion membrane {ECO:0000305|PubMed:12072526}; Multi-pass membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:15850490}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Glycoprotein C]: Virion membrane {ECO:0000305|PubMed:12072526}; Single-pass type I membrane protein {ECO:0000305}. Host Golgi apparatus membrane {ECO:0000269|PubMed:15850490}; Single-pass type I membrane protein {ECO:0000305}. Host endoplasmic reticulum membrane {ECO:0000269|PubMed:15850490}; Single-pass type I membrane protein {ECO:0000305}. Note=Interaction between glycoprotein C and glycoprotein N is essential for proper targeting of glycoprotein C to the Golgi complex, where virion budding occurs. {ECO:0000269|PubMed:15850490}.; SUBCELLULAR LOCATION: [Non-Structural protein M]: Host Golgi apparatus membrane {ECO:0000269|PubMed:17409136}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MHISLMYAILCLQLCGLGETHGSHNETRHNKTDTMTTPGDNPSSEPPVSTALSITLDPSTVTPTTPASGLEGSGEVYTSPPITTGSLPLSETTPELPVTTGTDTLSAGDVDPSTQTAGGTSAPTVRTSLPNSPSTPSTPQDTHHPVRNLLSVTSPGPDETSTPSGTGKESSATSSPHPVSNRPPTPPATAQGPTENDSHNATEHPESLTQSATPGLMTSPTQIVHPQSATPITVQDTHPSPTNRSKRNLKMEIILTLSQGLKKYYGKILRLLQLTLEEDTEGLLEWCKRNLGLDCDDTFFQKRIEEFFITGEGHFNEVLQFRTPGTLSTTESTPAGLPTAEPFKSYFAKGFLSIDSGYYSAKCYSGTSNSGLQLINITRHSTRIVDTPGPKITNLKTINCINLKASIFKEHREVEINVLLPQVAVNLSNCHVVIKSHVCDYSLDIDGAVRLPHIYHEGVFIPGTYKIVIDKKNKLNDRCTLFTDCVIKGREVRKGQSVLRQYKTEIRIGKASTGSRRLLSEEPSDDCISRTQLLRTETAEIHGDNYGGPGDKITICNGSTIVDQRLGSELGCYTINRVRSFKLCENSATGKNCEIDSVPVKCRQGYCLRITQEGRGHVKLSRGSEVVLDACDTSCEIMIPKGTGDILVDCSGGQQHFLKDNLIDLGCPKIPLLGKMAIYICRMSNHPKTTMAFLFWFSFGYVITCILCKAIFYLLIIVGTLGKRLKQYRELKPQTCTICETTPVNAIDAEMHDLNCSYNICPYCASRLTSDGLARHVIQCPKRKEKVEETELYLNLERIPWVVRKLLQVSESTGVALKRSSWLIVLLVLFTVSLSPVQSAPIGQGKTIEAYRAREGYTSICLFVLGSILFIVSCLMKGLVDSVGNSFFPGLSICKTCSISSINGFEIESHKCYCSLFCCPYCRHCSTDKEIHKLHLSICKKRKKGSNVMLAVCKLMCFRATMEVSNRALFIRSIINTTFVLCILILAVCVVSTSAVEMENLPAGTWEREEDLTNFCHQECQVTETECLCPYEALVLRKPLFLDSTAKGMKNLLNSTSLETSLSIEAPWGAINVQSTYKPTVSTANIALSWSSVEHRGNKILVSGRSESIMKLEERTGISWDLGVEDASESKLLTVSVMDLSQMYSPVFEYLSGDRQVGEWPKATCTGDCPERCGCTSSTCLHKEWPHSRNWRCNPTWCWGVGTGCTCCGLDVKDLFTDYMFVKWKVEYIKTEAIVCVELTSQERQCSLIEAGTRFNLGPVTITLSEPRNIQQKLPPEIITLHPRIEEGFFDLMHVQKVLSASTVCKLQSCTHGVPGDLQVYHIGNLLKGDKVNGHLIHKIEPHFNTSWMSWDGCDLDYYCNMGDWPSCTYTGVTQHNHASFVNLLNIETDYTKNFHFHSKRVTAHGDTPQLDLKARPTYGAGEITVLVEVADMELHTKKIEISGLKFASLACTGCYACSSGISCKVRIHVDEPDELTVHVKSDDPDVVAASSSLMARKLEFGTDSTFKAFSAMPKTSLCFYIVEREHCKSCSEEDTKKCVNTKLEQPQSILIEHKGTIIGKQNSTCTAKASCWLESVKSFFYGLKNMLSGIFGNVFMGIFLFLAPFILLILFFMFGWRILFCFKCCRRTRGLFKYRHLKDDEETGYRRIIEKLNNKKGKNKLLDGERLADRRIAELFSTKTHIG
InterPro domains: - IPR012487: Nairovirus M polyprotein-like (family) [1-1684]
- IPR048791: Glycoprotein Gc, C-terminal, bunyavirales (domain) [1410-1631]
- IPR048801: Structural glycoprotein Gn, nairovirus (domain) [521-842]
- IPR048529: GP38, nairovirus (domain) [267-508]
- IPR002532: Hantavirus glycoprotein Gc, N-terminal domain (domain) [1082-1409]
- IPR049491: Mucin-like domain, nairovirus (domain) [29-247]
- IPR048796: Non-Structural protein M domain, nairovirus (domain) [853-954]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0004888 (transmembrane signaling receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0009566 (fertilization), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)