Protein: Bromodomain-containing protein 2 (O27.1.1) (P25440)
Organism: Homo sapiens (Human)
Function: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
Subcellular location: Nucleus {ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:25593309, ECO:0000269|PubMed:28262505}. Note=Detected on chromatin and nucleosomes. {ECO:0000269|PubMed:18406326}.
Sequence: MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
InterPro domains: - IPR018359: Bromodomain, conserved site (conserved_site) [96-428]
- IPR050935: Bromodomain-containing chromatin reader (family) [26-797]
- IPR043508: Brdt, bromodomain, repeat I (domain) [74-180]
- IPR043509: Brdt, bromodomain, repeat II (domain) [349-450]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [59-460]
- IPR027353: NET domain (domain) [632-714]
- IPR038336: NET domain superfamily (homologous_superfamily) [634-714]
- IPR001487: Bromodomain (domain) [72-455]
Interaction partners: - Histone H4
- Bromodomain-containing protein 3
- Histone H4-like protein type G
- Bromodomain-containing protein 4
- Transcription factor E2F1
- Bromodomain testis-specific protein
- Histone-lysine N-methyltransferase NSD3
- Cyclin-dependent kinase 9
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
- Cyclin-T1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding), GO:0005515 (protein binding), GO:0042393 (histone binding), GO:0140030 (modification-dependent protein binding), GO:0140033 (acetylation-dependent protein binding), GO:0070577 (lysine-acetylated histone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0090068 (positive regulation of cell cycle process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010564 (regulation of cell cycle process), GO:0009891 (positive regulation of biosynthetic process), GO:0045787 (positive regulation of cell cycle), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0007346 (regulation of mitotic cell cycle), GO:0010556 (regulation of macromolecule biosynthetic process), GO:1901989 (positive regulation of cell cycle phase transition), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0045931 (positive regulation of mitotic cell cycle), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1902680 (positive regulation of RNA biosynthetic process), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1902808 (positive regulation of cell cycle G1/S phase transition), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:1903506 (regulation of nucleic acid-templated transcription), GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016604 (nuclear body), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)