Protein: Ubiquitin-conjugating enzyme E2 variant 2 (Ubc-like protein MMS2) (Q9D2M8)
Organism: Mus musculus (Mouse)
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Sequence: MAVSTGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVDARSIPVLAKWQNSYSIKVILQELRRLMMSKENMKLPQPPEGQTYNN
InterPro domains: - IPR016135: Ubiquitin-conjugating enzyme/RWD-like (homologous_superfamily) [1-145]
- IPR000608: Ubiquitin-conjugating (UBC), catalytic core domain (domain) [10-145]
Interaction partners: - Ubiquitin-conjugating enzyme E2 N
- Ubiquitin-ribosomal protein eS31 fusion protein
- Helicase-like transcription factor
- Ubiquitin-conjugating enzyme E2 A
- Ubiquitin-conjugating enzyme E2 W
- Ubiquitin-conjugating enzyme E2 B
- Polyubiquitin-C
- E3 ubiquitin-protein ligase RNF8
- Polyubiquitin-B
- Ubiquitin-conjugating enzyme E2 G1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0061650 (ubiquitin-like protein conjugating enzyme activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0044390 (ubiquitin-like protein conjugating enzyme binding), GO:0031624 (ubiquitin conjugating enzyme binding), GO:0061631 (ubiquitin conjugating enzyme activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006281 (DNA repair), GO:0006301 (postreplication repair)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)