Protein: Rod outer segment membrane protein 1 (ROSP1) (Tetraspanin-23) (Tspan-23) (Q03395)
Organism: Homo sapiens (Human)
Function: Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity).
Subcellular location: Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:P32958, ECO:0000305|PubMed:1610568}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000269|PubMed:1610568}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MAPVLPLVLPLQPRIRLAQGLWLLSWLLALAGGVILLCSGHLLVQLRHLGTFLAPSCQFPVLPQAALAAGAVALGTGLVGVGASRASLNAALYPPWRGVLGPLLVAGTAGGGGLLVVGLGLALALPGSLDEALEEGLVTALAHYKDTEVPGHCQAKRLVDELQLRYHCCGRHGYKDWFGVQWVSSRYLDPGDRDVADRIQSNVEGLYLTDGVPFSCCNPHSPRPCLQNRLSDSYAHPLFDPRQPNQNLWAQGCHEVLLEHLQDLAGTLGSMLAVTFLLQALVLLGLRYLQTALEGLGGVIDAGGETQGYLFPSGLKDMLKTAWLQGGVACRPAPEEAPPGEAPPKEDLSEA
InterPro domains: - IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [127-262]
- IPR000830: Peripherin/rom-1 (family) [20-289]
- IPR018498: Peripherin/rom-1, conserved site (conserved_site) [210-225]
- IPR018499: Tetraspanin/Peripherin (family) [20-284]
- IPR042026: Peripherin, extracellular domain (domain) [126-265]
Interaction partners: - Peripherin-2
- Rhodopsin
- Cyclic nucleotide-gated channel beta-1
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Fascin-2
- Glycogen phosphorylase, muscle form
- Cyclic nucleotide-gated channel alpha-1
- Ferritin heavy chain
- Muscarinic acetylcholine receptor M1
- Uteroglobin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0051606 (detection of stimulus), GO:0009581 (detection of external stimulus), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0060042 (retina morphogenesis in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0003407 (neural retina development), GO:0060255 (regulation of macromolecule metabolic process), GO:0009582 (detection of abiotic stimulus), GO:0060041 (retina development in camera-type eye), GO:0050906 (detection of stimulus involved in sensory perception), GO:0009887 (animal organ morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0009416 (response to light stimulus), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0050962 (detection of light stimulus involved in sensory perception), GO:0035845 (photoreceptor cell outer segment organization), GO:0007600 (sensory perception), GO:0010468 (regulation of gene expression), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0022008 (neurogenesis), GO:0061298 (retina vasculature development in camera-type eye), GO:0007399 (nervous system development), GO:0072359 (circulatory system development), GO:0060219 (camera-type eye photoreceptor cell differentiation), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0030182 (neuron differentiation), GO:0009583 (detection of light stimulus), GO:0050953 (sensory perception of light stimulus), GO:0033365 (protein localization to organelle), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0009584 (detection of visible light), GO:0065003 (protein-containing complex assembly), GO:0046530 (photoreceptor cell differentiation), GO:0050908 (detection of light stimulus involved in visual perception), GO:0150063 (visual system development), GO:0042461 (photoreceptor cell development), GO:0048699 (generation of neurons), GO:0061512 (protein localization to cilium), GO:0007601 (visual perception), GO:0051259 (protein complex oligomerization), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0001754 (eye photoreceptor cell differentiation), GO:0051260 (protein homooligomerization), GO:0097499 (protein localization to non-motile cilium), GO:0051291 (protein heterooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)