Protein: L-arabinitol 4-dehydrogenase (LAD) (EC 1.1.1.12) (B6HI95)
Organism: Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Function: Catalyzes the NAD-dependent oxidation of L-arabinitol to L-xylulose in the fungal L-arabinose catabolic pathway. L-arabinose catabolism is important for using plant material as a carbon source. NADP cannot act as a cosubstrate.
Sequence: MASATVTKTNIGVYTNPKHDLWIADSSPTAEDINAGKGLKAGEVTIEVRSTGICGSDVHFWHAGCIGPMIVTGDHVLGHESAGQVLAVAPDVTHLKVGDRVAVEPNVICNACEPCLTGRYNGCVNVAFLSTPPVDGLLRRYVNHPAVWCHKIGDMSYEDGAMLEPLSVTLAAIERSGLRLGDPLLITGAGPIGLISLLSARAAGACPIVITDIDEGRLAFAKSLVPEVRTYKVEIGKSAEECADGIINALNDGQGSGPDALRPKLALECTGVESSVNSAIWSVKFGGKVFVIGVGKNEMTIPFMRLSTQEIDLQYQYRYCNTWPRAIRLIQNGVIDLSKLVTHRYSLENALQAFETASNPKTGAIKVQIMSSEEDVKAATAGQKY
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [159-333]
- IPR020843: Enoylreductase domain (domain) [24-365]
- IPR045306: Sorbitol dehydrogenase-like (family) [39-370]
- IPR013149: Alcohol dehydrogenase-like, C-terminal (domain) [191-331]
- IPR011032: GroES-like superfamily (homologous_superfamily) [32-189]
- IPR013154: Alcohol dehydrogenase-like, N-terminal (domain) [41-153]
- IPR002328: Alcohol dehydrogenase, zinc-type, conserved site (conserved_site) [78-92]
Interaction partners: - D-xylose reductase [NAD
- Phosphotransferase
- Phosphotransferase
- Mannitol 2-dehydrogenase
- Phosphotransferase
- Pc22g22030 protein
- Pc16g10410 protein
- fructan beta-fructosidase
- Pc22g01350 protein
- Pc21g18520 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006066 (alcohol metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:0019400 (alditol metabolic process), GO:0019751 (polyol metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0016052 (carbohydrate catabolic process), GO:0019405 (alditol catabolic process), GO:0046174 (polyol catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)