wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Glucosamine-6-phosphate isomerase (Q04802)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Sequence: MRQAIFSNPNDAAEYLANYIIAKINSTPRTFVLGLPTGSSPEGIYAKLIEANKQGRVSFKNVVTFNMDEYLGLAPSDLQSYHYFMYDKFFNHIDIPRENIHILNGLAANIDEECANYEKKIKQYGRIDLFLGGLGPEGHLAFNEAGSSRNSKTRKVELVESTIKANCRFFGNDESKVPKYALSVGISTILDNSDEIAIIVLGKNKQFALDKTVNGKPNDPKYPSSYLQDHANVLIVCDNAAAGLKSKL
InterPro domains: - IPR006148: Glucosamine/galactosamine-6-phosphate isomerase (domain) [10-232]
- IPR018321: Glucosamine-6-phosphate isomerase, conserved site (conserved_site) [121-139]
- IPR037171: NagB/RpiA transferase-like (homologous_superfamily) [1-242]
- IPR004547: Glucosamine-6-phosphate isomerase (family) [1-244]
Interaction partners: - N-acetylglucosamine-6-phosphate deacetylase
- N-acetylglucosamine kinase 1
- Glucosamine 6-phosphate N-acetyltransferase
- Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
- Glucose-6-phosphate isomerase
- Mannose-6-phosphate isomerase
- Phosphotransferase
- Hexokinase-2
- Phosphotransferase
- Ngt1p
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0019239 (deaminase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006040 (amino sugar metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062039 (biofilm matrix), GO:0062040 (fungal biofilm matrix)
Protein: N-acetylneuraminate epimerase (P39371)
Organism: Escherichia coli (strain K12)
Function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete successfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses. Forms linear aceneuramate during interconversion of Neu5Ac anomers
Subcellular location: Periplasm
Sequence: MNKTITALAIMMASFAANASVLPETPVPFKSGTGAIDNDTVYIGLGSAGTAWYKLDTQAKDKKWTALAAFPGGPRDQATSAFIDGNLYVFGGIGKNSEGLTQVFNDVHKYNPKTNSWVKLMSHAPMGMAGHVTFVHNGKAYVTGGVNQNIFNGYFEDLNEAGKDSTAIDKINAHYFDKKAEDYFFNKFLLSFDPSTQQWSYAGESPWYGTAGAAVVNKGDKTWLINGEAKPGLRTDAVFELDFTGNNLKWNKLAPVSSPDGVAGGFAGISNDSLIFAGGAGFKGSRENYQNGKNYAHEGLKKSYSTDIHLWHNGKWDKSGELSQGRAYGVSLPWNNSLLIIGGETAGGKAVTDSVLITVKDNKVTVQN
InterPro domains: - IPR015915: Kelch-type beta-propeller (homologous_superfamily) [13-366]
- IPR056734: N-acetylneuraminate epimerase (family) [23-366]
- IPR019936: N-acetylneuraminate epimerase, proteobacteria (family) [1-368]
Interaction partners: - N-acetylneuraminic acid outer membrane channel protein NanC
- Probable 9-O-acetyl-N-acetylneuraminic acid deacetylase
- Sialic acid transporter NanT
- Putative N-acetylmannosamine-6-phosphate 2-epimerase
- N-acetylneuraminate lyase
- Sialic acid transporter NanX
- 2,7-anhydro-N-acetylneuraminate hydratase
- N-acetylneuraminate anomerase NanQ
- N-acetylmannosamine kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016854 (racemase and epimerase activity), GO:0016857 (racemase and epimerase activity, acting on carbohydrates and derivatives)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:0044248 (cellular catabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0016052 (carbohydrate catabolic process), GO:0005984 (disaccharide metabolic process), GO:0046352 (disaccharide catabolic process), GO:0009313 (oligosaccharide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: N-acetylneuraminate anomerase NanQ (P45424)
Organism: Escherichia coli (strain K12)
Function: Opens both the alpha- and beta-forms of N-acetylneuraminate (sialic acid; Neu5Ac) to provide aceneuramate, the preferred substrate for NanA. Has preferential activity on the beta-anomer rather than the alpha-anomer. Accelerates a reaction that is spontaneous at slightly alkaline pH, facilitates the reaction at acidic pH
Subcellular location: Cytoplasm
Sequence: MMMGEVQSLPSAGLHPALQDALTLALAARPQEKAPGRYELQGDNIFMNVMTFNTQSPVEKKAELHEQYIDIQLLLNGEERILFGMAGTARQCEEFHHEDDYQLCSTIDNEQAIILKPGMFAVFMPGEPHKPGCVVGEPGEIKKVVVKVKADLMA
InterPro domains: - IPR037012: NanQ anomerase/TabA/YiaL superfamily (homologous_superfamily) [1-153]
- IPR004375: NanQ anomerase/TabA/YiaL family (family) [1-153]
- IPR049827: N-acetylneuraminate anomerase NanQ (family) [1-152]
Interaction partners: - N-acetylmannosamine kinase
- N-acetylneuraminate lyase
- Putative N-acetylmannosamine-6-phosphate 2-epimerase
- Sialic acid transporter NanT
- HTH-type transcriptional repressor NanR
- 2,7-anhydro-N-acetylneuraminate hydratase
- N-acetylneuraminate epimerase
- Sialic acid transporter NanX
- N-acetylneuraminic acid outer membrane channel protein NanC
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Nitrate/nitrite antiporter NarK (P10903)
Organism: Escherichia coli (strain K12)
Function: Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate/nitrite exchanger, and protons are unlikely to be co-transported
Subcellular location: Cell inner membrane; Multi-pass membrane protein
Sequence: MSHSSAPERATGAVITDWRPEDPAFWQQRGQRIASRNLWISVPCLLLAFCVWMLFSAVAVNLPKVGFNFTTDQLFMLTALPSVSGALLRVPYSFMVPIFGGRRWTAFSTGILIIPCVWLGFAVQDTSTPYSVFIIISLLCGFAGANFASSMANISFFFPKQKQGGALGLNGGLGNMGVSVMQLVAPLVVSLSIFAVFGSQGVKQPDGTELYLANASWIWVPFLAIFTIAAWFGMNDLATSKASIKEQLPVLKRGHLWIMSLLYLATFGSFIGFSAGFAMLSKTQFPDVQILQYAFFGPFIGALARSAGGALSDRLGGTRVTLVNFILMAIFSGLLFLTLPTDGQGGSFMAFFAVFLALFLTAGLGSGSTFQMISVIFRKLTMDRVKAEGGSDERAMREAATDTAAALGFISAIGAIGGFFIPKAFGSSLALTGSPVGAMKVFLIFYIACVVITWAVYGRHSKK
InterPro domains: - IPR004737: Nitrate transporter NarK/NarU-like (family) [36-418]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [1-463]
- IPR011701: Major facilitator superfamily (family) [45-422]
- IPR044772: Nitrate transporter (family) [15-457]
Interaction partners: - Respiratory nitrate reductase 1 alpha chain
- Respiratory nitrate reductase 1 beta chain
- Respiratory nitrate reductase 1 gamma chain
- Nitrite reductase (NADH) large subunit
- Nitrate reductase molybdenum cofactor assembly chaperone NarJ
- Nitrate reductase molybdenum cofactor assembly chaperone NarJ
- Respiratory nitrate reductase 2 alpha chain
- Respiratory nitrate reductase 2 beta chain
- Respiratory nitrate reductase 2 gamma chain
- Respiratory nitrate reductase 2 gamma chain
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0005452 (solute:inorganic anion antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0071705 (nitrogen compound transport), GO:1902025 (nitrate import), GO:0015706 (nitrate transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Ubiquitin-like protein NEDD8 (Q54XV3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Ubiquitin-like protein which plays an important role in cell cycle control. Attachment of nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity)
Subcellular location: Nucleus
Sequence: MLIKVKTLTGKEIEIDIDPTDKIQRIKERVEEKEGIPPSQQRLIFGGKQMGDDKPASEYSIEGGSVLHLVLALRGGL
InterPro domains: - IPR050158: Ubiquitin and ubiquitin-like (family) [1-76]
- IPR019954: Ubiquitin conserved site (conserved_site) [27-52]
- IPR019956: Ubiquitin domain (domain) [11-74]
- IPR038738: Nedd8-like ubiquitin (domain) [3-76]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [1-76]
- IPR000626: Ubiquitin-like domain (domain) [1-76]
Interaction partners: - NEDD8-activating enzyme E1 catalytic subunit
- NEDD8-conjugating enzyme Ubc12
- COP9 signalosome complex subunit 5
- Probable ubiquitin carboxyl-terminal hydrolase
- COP9 signalosome complex subunit 7
- COP9 signalosome complex subunit 6
- Small ubiquitin-like protein
- Cullin-1
- COP9 signalosome complex subunit 8
- COP9 signalosome complex subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0045116 (protein neddylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Nuclear envelope integral membrane protein 1 (E7FE40)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Contributes to nuclear envelope stiffness in germ cells (By similarity). Involved in male and female fertility. Essential for normal erythropoiesis (By similarity). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity)
Subcellular location: Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side
Sequence: MAGFMKYKSVSTTIETVRLKLILTAVLFLFPFSQTSGASRPIIEIKDGQEIKVQAAQHFCYNNTIIPGWRETWTRIQVRVWSTTKLKVTVVNDEQDLKELEHFSIWKLVQYFVREQTNETTISVSLFNNKTCFRVDPSESRTLYTVQPSRHFDIYLFLVFLAGVLLFFYADVLSRSQVFHYSAGMSTGMIASLLILIFIVYRFLPKKSPFYMLVVGGWSFSLYIIQLVFRNLQVILTDHWHLAIGYVFVVGFISFAVCYRYGPLVEERSINILSWALQIFGLLLVYAGIQVQQVAFAIMIAAFCSKNLEYPFNTAFMLYHKLKPKKLEPRRLLTEEEFQRQSEVETQKALEELRKYCGSPDFNTWKTVSRLQSPKRFADFIEGSPHLLSNEVSVHMQEYGLGGSFFEDELFSTDEEDKEEEEDGWETEDDIKPEVTSPRMNNTRGK
InterPro domains: - IPR019358: NEMP family (family) [17-427]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0043621 (protein self-association)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005637 (nuclear inner membrane), GO:0005634 (nucleus)
Protein: Nuclear envelope integral membrane protein 2 (F1QYC4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Contributes to nuclear envelope stiffness in germ cells (By similarity). Involved in male and female fertility
Subcellular location: Nucleus inner membrane; Multi-pass membrane protein; Nucleoplasmic side
Sequence: MEKLAAFILVLTLLCAYWQSAEGIREYSYADCTDVKGDSAHRYSGSRCFCYSPGTVIKWKDIWSTFKVNVSSNVDVVVVFPMETINCHHPDDLLTVMNCFVEHYWPSTVQRETSLEIPLVDVDICFMIKSPRSNTEYTLHVSNKRLNRMCFLLFVCGLILFFGARNICRSSLFFYTTGVSLGIIATFVFLTLLLRNFVPKRGLFLVLLGAGSGLSYMGIQRVLNEWDDIVTEHWMELLAYVLISGLFSFAVCYKHGPITNKHTLNFMTCSMQAVGIVLLYYGITFPPAYFVLVAVLLCWKILPLAWSLLMGICSLFYSFLALFRRRRRPTVRLLTEEEYREQGEIHTRASLDELREYCNRPGFPAWETVLRLRSPQRFAEFLRQGSHITQEEHQNHENHYGLGGAYYENVIFNNSSSSDTQSHREEAEDNSEDEIVGNSPPVLNNLPSPTIYPPTICPYPPVTYTPQPEPLDPEDQDFF
InterPro domains: - IPR019358: NEMP family (family) [4-435]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0016043 (cellular component organization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0120036 (plasma membrane bounded cell projection organization), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031965 (nuclear membrane), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005637 (nuclear inner membrane), GO:0005634 (nucleus)
Protein: Early nodulin-40-1 (P0DO61)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Modulates the action of auxin, and may function as plant growth regulator that alters phytohormone responses (Probable). During symbiosis with rhizobacteria such as Sinorhizobium meliloti SM2011, in response to Nod factors and under nitrogen limitation, involved in nodule initiation by inducing dedifferentiation and division of root cortical cells (primordium formation), and essential for bacteroid development during nodulation; this processus is repressed by ethylene. During symbiosis with arbuscular mycorrhizal fungi such as Glomus mosseae and G.intraradices, promotes mycorrhizal colonization in the root cortex and enhances the formation of arbuscules. Involved in root-knot nematode Meloidogyne incognita giant cells formation
Sequence: MKLLCWEKSIHGS
InterPro domains: - IPR013186: Early nodulin 40 (family) [4-13]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0006952 (defense response), GO:0045595 (regulation of cell differentiation), GO:0043207 (response to external biotic stimulus), GO:0001817 (regulation of cytokine production), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0050832 (defense response to fungus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Early nodulin-40-2 (P0DO62)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Modulates the action of auxin, and may function as plant growth regulator that alters phytohormone responses (Probable). During symbiosis with Sinorhizobium meliloti SM2011, involved in nodule initiation and essential for bacteroid development during nodulation
Sequence: MNLCWQKSIYD
InterPro domains: - IPR013186: Early nodulin 40 (family) [1-9]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0009620 (response to fungus), GO:0009608 (response to symbiont), GO:0043207 (response to external biotic stimulus), GO:0009610 (response to symbiotic fungus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: NPC intracellular cholesterol transporter 2 (Q9DGJ3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol
Subcellular location: Secreted. Endoplasmic reticulum. Lysosome. Note=Interaction with cell-surface M6PR mediates endocytosis and targeting to lysosomes
Sequence: MDYRVLGVVLLSFLAYTCADPVKFVDCGSVDGKVVQVDIKPCSQQPCKLHKGQSYTVNVTFSSGVESQTSKAVVHGVLAGVPVPFPIPIDDGCKSGIQCPIVPQKPYNYVTELPVKTEYPAIKVVVEWELRDDSSKDLFCIKFPVQIVN
InterPro domains: - IPR033916: Npc2 like, ML domain (domain) [24-145]
- IPR003172: MD-2-related lipid-recognition domain (domain) [22-147]
- IPR039670: Sterol transport protein NPC2-like (family) [9-148]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [21-148]
Interaction partners: - NPC intracellular cholesterol transporter 1 isoform X1
- NPC intracellular cholesterol transporter 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0097159 (organic cyclic compound binding), GO:0008289 (lipid binding), GO:0043178 (alcohol binding), GO:0005496 (steroid binding), GO:0032934 (sterol binding), GO:0015485 (cholesterol binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009615 (response to virus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0140546 (defense response to symbiont), GO:0051607 (defense response to virus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)