wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (3-beta-hydroxysteroid dehydrogenase) (Q7ZZC3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MALSGEVCVVTGACGFLGEKLVRLLLEEENLSEIRLLDRNIRSELIQTLEDGRGETKVSVIEGDIRDRELLRRACKGATLVFHTASLIDYNGAVEYSELHAVNVKATRLLLETCIQQSVSSFIYTSSIEVACPNRSGEPIINGHEDTPYSSYPISNYSKTKQEAEQICLQANGELLRDGGHLATCALRPMFIYGPGCRFTLNKLRDAIRSGNVQHRLSQQSAKVNPVYVGNAALAHLQAGRALRDPEKRAVVGGNFYYVSDDTPHISYCDLTHALMSPLGFSIQNKPILPIFLLYLLAFFMEILQAVLRPVLRFTPPLNRQLVTMVNTPFSFSYQKACREFGYSPRYDWEEARRSTTDWLASVLPAERRLANKT
InterPro domains: - IPR002225: 3-beta hydroxysteroid dehydrogenase/isomerase (domain) [9-287]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [5-362]
- IPR050177: Bifunctional lipid A modification and metabolic enzymes (family) [8-361]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016229 (steroid dehydrogenase activity), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor), GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0043473 (pigmentation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Prolactin-inducible protein homolog (14 kDa submandibular gland protein) (SMGP) (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (P02816)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Secreted {ECO:0000305}.
Sequence: MQGLSFTFSAVTLFLVLCLQLGIIESQDDENVRKPLLIEIDVPSTAQENQEITVQVTVETQYRECMVIKAYLVSNEPMEGAFNYVQTRCLCNDHPIRFFWDIIITRTVTFATVIDIVREKNICPNDMAVVPITANRYYTYNTVRMN
InterPro domains: - IPR014756: Immunoglobulin E-set (homologous_superfamily) [30-143]
- IPR007990: Prolactin-inducible protein (family) [1-146]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [29-146]
Interaction partners: - Zinc-alpha-2-glycoprotein
- BPI fold-containing family A member 2
- Proline rich, lacrimal 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0002521 (leukocyte differentiation), GO:0042113 (B cell activation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030183 (B cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Lactate-binding periplasmic protein TTHA0766 (ABC transporter, solute-binding protein) (Extracytoplasmic solute receptor protein TTHA0766) (TRAP transporter lactate-binding subunit P) (Q5SK82)
Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system involved in the uptake of lactate. This protein specifically binds L-lactate.
Subcellular location: Periplasm {ECO:0000250|UniProtKB:P37676}.
Sequence: MKRVSRRAFLRRLGVGVAATAAFSPLAVAQARRYRWRIQTAWDAGTVGYSLFQKFTERVKELTDGQLEVQPFPAGAVVGTFDMFDAVKTGVLDGMNPFTLYWAGRMPVTAFLSSYALGLDRPDQWETWFYSLGGLDIARRAFAEQGLFYVGPVQHDLNIIHSKKPIRRFEDFKGVKLRVPGGMIAEVFAAAGASTVLLPGGEVYPALERGVIDAADFVGPAVNYNLGFHQVAKYIIMGPPETPAIHQPVDLMDFTINLNRWRSLPKPLQERFIAAVHEYSWIHYAGIQKANLEAWPKYRQAGVEVIRLSNEDVRKFRRLAIPIWFKWAKMDKYSREAFASQLEYMKGIGYVTDEELKGLSL
InterPro domains: - IPR026289: Solute binding protein, TakP-like (family) [4-361]
- IPR038404: TRAP transporter solute receptor DctP superfamily (homologous_superfamily) [32-361]
- IPR041721: Lactate-binding periplasmic protein TTHA0766 (family) [35-345]
- IPR006311: Twin-arginine translocation pathway, signal sequence (conserved_site) [1-31]
- IPR018389: TRAP transporter solute receptor DctP (family) [17-343]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0005342 (organic acid transmembrane transporter activity), GO:0043168 (anion binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0031975 (envelope), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0031406 (carboxylic acid binding), GO:0005342 (organic acid transmembrane transporter activity), GO:0051225 (spindle assembly), GO:0015291 (secondary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0006835 (dicarboxylic acid transport), GO:0015740 (C4-dicarboxylate transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: Transmembrane protein 235 (Claudin-27) (B1AQL3)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000305|PubMed:21689651}.
Sequence: MALLATLLLSAALGALLSFALLAAAVASDYWYILEVADAGGLGGVQLFSHSGLWRTCEGQNSCVPLIDPFASAGLEVSPSVQHLLSLHRTVMVVLPLSLVLIVCGWVCGLLSSLSQSVPLLLATGCYFLLGGALTLAGLSIYISYSHLAFVEAARTYGVTHVQNVHISFGWSLALAWASCASEVLSGALLLAAARLLSLSQRPGVPHSVIL
InterPro domains: - IPR039951: Transmembrane protein TMEM114/TMEM235 (family) [4-208]
- IPR004031: PMP-22/EMP/MP20/Claudin (family) [16-191]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0050793 (regulation of developmental process), GO:0019725 (cellular homeostasis), GO:0006885 (regulation of pH), GO:0050794 (regulation of cellular process), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0045595 (regulation of cell differentiation), GO:0030641 (regulation of cellular pH), GO:0055080 (monoatomic cation homeostasis), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0051453 (regulation of intracellular pH), GO:0051452 (intracellular pH reduction), GO:0030003 (intracellular monoatomic cation homeostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0016327 (apicolateral plasma membrane)
Protein: beta-glucosidase (EC 3.2.1.21) (Q2UIR4)
Organism: Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MLTSPTARTSVRISRPATTERPNTVLTSGSLDIAMVQVVSRTLTPPTSNMKLSAALSTLAALQPAVGAAVQNRASDVADLEHYWSYGHSEPVYPTPETKGLGDWEEAFTKARSLVAQMTDKEKNNITYGYSSTANGCGGTSGGVPRLGFPGICLQDAGNGVRGTDMVNSYASGVHVGASWNRDLTYSRAQYMGAEFKRKGVNVALGPVAGPIGRIARGGRNWEGFSNDPYLSGALTGDTVRGLQESVIACVKHLIGNEQETHRSTPSMLANSRNQSSSSNLDDKTMHELYLWPFQDAVKAGAGSVMCSYNRINNSYGCQNSKAMNGLLKGELGFQGFVVSDWGAQHTGIASAAAGLDMAMPSSSYWENGTLALAVKNESLPSTRLDDMATRIVATWYKYAEIENPGHGLPYSLLAPHNLTDARDPKSKSTILQGAVEGHVLVKNTNNALPLKKPQFLSLFGYDAVAAARNTMDDLDWNMWSMGYDNSLTYPNGSAVDAMMLKYIFLSSANPSAFGPGVALNATTITGGGSGASTASYIDAPFNAFQRQAYDDDTFLAWDFASQNPLVNPASDACIVFINEQSSEGWDRPYLADPYSDTLVQNVASQCSNTMVVIHNAGVRLVDRWIENDNITAVIYAHLPGQDSGRALVEVMYGKQSPSGRLPYTVAKNESDYGSLLNPVIQSGTDDIYYPQDNFTEGVYIDYKAFVAANITPRYEFGYGLTYSTFDYSDLKVSTSSNVSTSYLAPGTTVAEGGLPSVWDIIATVTCTVSNTGSVAAAEVAQLYIGIPGGPAKVLRGFEKQLIEPGQQVQVTFDLTRRDLSTWDTEKQNWGLQAGSYALYVGKSVLDIQLTGSLSL
InterPro domains: - IPR001764: Glycoside hydrolase, family 3, N-terminal (domain) [146-393]
- IPR036962: Glycoside hydrolase, family 3, N-terminal domain superfamily (homologous_superfamily) [74-400]
- IPR017853: Glycoside hydrolase superfamily (homologous_superfamily) [102-409]
- IPR002772: Glycoside hydrolase family 3 C-terminal domain (domain) [440-703]
- IPR036881: Glycoside hydrolase family 3 C-terminal domain superfamily (homologous_superfamily) [426-726]
- IPR026891: Fibronectin type III-like domain (domain) [779-845]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [726-856]
- IPR050288: Cellulose-degrading glycosyl hydrolase 3 (family) [65-855]
- IPR019800: Glycoside hydrolase, family 3, active site (active_site) [327-344]
Interaction partners: - Probable glucan endo-1,3-beta-glucosidase eglC
- Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein
- beta-glucosidase
- Glucanase
- Probable 1,4-beta-D-glucan cellobiohydrolase A
- beta-glucosidase
- Probable beta-glucosidase H
- beta-glucosidase
- Probable glucan 1,3-beta-glucosidase D
- beta-glucosidase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds), GO:0015926 (glucosidase activity), GO:0008422 (beta-glucosidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0005975 (carbohydrate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Solute carrier family 35 member E3 (Bladder cancer-overexpressed gene 1 protein) (Q7Z769)
Organism: Homo sapiens (Human)
Function: Putative transporter.
Subcellular location: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Sequence: MALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNMSLTLVHFVVTWLGLYICQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVKFNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGPWSVSALLMVLLSGVIAFMVNLSIYWIIGNTSPVTYNMFGHFKFCITLFGGYVLFKDPLSINQALGILCTLFGILAYTHFKLSEQEGSRSKLAQRP
InterPro domains: - IPR037185: Multidrug transporter EmrE superfamily (homologous_superfamily) [201-296]
- IPR050186: Triose Phosphate/Phosphate Translocator (family) [18-302]
- IPR004853: Sugar phosphate transporter domain (domain) [22-294]
Interaction partners: - UPF0235 protein C15orf40
- Nuclear pore complex protein Nup107
- E3 ubiquitin-protein ligase Mdm2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:0005338 (nucleotide-sugar transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0015780 (nucleotide-sugar transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015931 (nucleobase-containing compound transport), GO:1901264 (carbohydrate derivative transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Crystal protein (P21837)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Cytoplasmic vesicle, esterosome membrane. Note=Membrane-enclosed crystals (esterosome).
Sequence: MNKIIILLIILLSFDIISAAKKFGRKGIRTLGDNEVLLSDGAIRGTVTDTHRVFYGIPFARPPIDELRYEDPQPPKPWSYVRDGTKQRDQCIQDCKLGKGSCSEVGTSEDCLYLDVFIPRTVNPGSKVPVMVFIPGGAFTQGTGSCPLYDGLKFANSSVIVVNVNYRLGVLGFLCTGLLSGNFGFLDQVMALDWVQENIEVFGGDKNQVTIYGESAGAFSVAAHLSSEKSEGKFHRAILSSTPYTVGLKSQTVARGFAGRFSSKIGCDLEDIDCHRSKSPEEILAIQKELGLAIGDKILDAFTIWSPVVDGINVNEQPLTMIKQGTTHDVPTIIGDNQDEAILFVYMTYKNVVIPSSYRTMVHVLFGIANGNKVLEHYPLPGFLKDSRPILSKLLTDYLFRCPGRYHVSKSAQANESPIYHYQYKQVLSGGHSFEACEGLVCHGTELPMVFNTYESALDLDLEEEEEEFAEQLNNYFVNFIKYSNPSHPNGLPTPKVWNPTTKTTNTSLVMKLGFEVKDLITNDPKCDLFDSLSYNGYTKDQNRMRKSKK
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [33-531]
- IPR019819: Carboxylesterase type B, conserved site (conserved_site) [109-119]
- IPR019826: Carboxylesterase type B, active site (active_site) [202-217]
- IPR002018: Carboxylesterase, type B (domain) [34-526]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0042330 (taxis), GO:0042221 (response to chemical), GO:0006935 (chemotaxis), GO:0043327 (chemotaxis to cAMP)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix), GO:0005938 (cell cortex)
Protein: Non-specific lipid-transfer protein 5 (LTP 5) (Q9XFS7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity).
Sequence: MEGLLKLSTLVIVCMLVTAPMASEAAISCGAVTGSLGQCYNYLTRGGFIPRGCCSGVQRLNSLARTTRDRQQACRCIQGAARALGSRLNAGRAARLPGACRVRISYPISARTNCNTVR
InterPro domains: - IPR000528: Plant non-specific lipid-transfer protein/Par allergen (family) [10-117]
- IPR016140: Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain (domain) [29-114]
- IPR036312: Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain superfamily (homologous_superfamily) [26-118]
Interaction partners: - Non-specific lipid transfer protein GPI-anchored 2
- Non-specific lipid transfer protein GPI-anchored 1
- Non-specific lipid-transfer protein 9
- Probable pectinesterase/pectinesterase inhibitor 44
- COX assembly mitochondrial protein
- Ribosomal protein L31
- Ribosomal protein L18e/L15 superfamily protein
- Non-specific lipid-transfer protein 15
- Putative lipid-transfer protein DIR1
- AT5g03660/F17C15_80)
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0008289 (lipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005794 (Golgi apparatus), GO:0048046 (apoplast), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0009507 (chloroplast), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0031982 (vesicle), GO:0009505 (plant-type cell wall), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009534 (chloroplast thylakoid), GO:0009579 (thylakoid), GO:0097708 (intracellular vesicle)
Protein: Succinate dehydrogenase assembly factor 1, mitochondrial (SDH assembly factor 1) (SDHAF1) (Q9US02)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit sdh2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3E785}.
Sequence: MALSGLQRQVIHFYRRCLHAAKAKEQPYNERWMAFVHQEFRKNQTISKRDFFYIEHLLRVGQRQYEAYSRPEVKDIHFS
InterPro domains: - IPR045295: SDHAF1, LYR domain (domain) [4-66]
- IPR008011: Complex 1 LYR protein domain (domain) [8-65]
Interaction partners: - Succinate dehydrogenase iron-sulfur subunit, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006091 (generation of precursor metabolites and energy), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0022900 (electron transport chain), GO:0022904 (respiratory electron transport chain), GO:0045333 (cellular respiration)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Probable GTP-binding protein EngB (P38424)
Organism: Bacillus subtilis (strain 168)
Function: Necessary for normal cell division and for the maintenance of normal septation.
Sequence: MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLINRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITTREELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVRQTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR
InterPro domains: - IPR006073: GTP binding domain (domain) [25-143]
- IPR005225: Small GTP-binding domain (domain) [25-189]
- IPR030393: EngB-type guanine nucleotide-binding (G) domain (domain) [22-195]
- IPR019987: GTP-binding protein, ribosome biogenesis, YsxC (family) [7-193]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-195]
Interaction partners: - Ribosome biogenesis GTPase A
- Uncharacterized protein YqeH
- GTPase Der
- GTPase Obg
- Small ribosomal subunit biogenesis GTPase RsgA
- Large ribosomal subunit protein bL17
- Putative TrmH family tRNA/rRNA methyltransferase YacO
- Large ribosomal subunit protein uL3
- 23S rRNA
- tRNA modification GTPase MnmE
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0051302 (regulation of cell division), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051781 (positive regulation of cell division), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051053 (negative regulation of DNA metabolic process), GO:0051052 (regulation of DNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0006275 (regulation of DNA replication), GO:0008156 (negative regulation of DNA replication), GO:0090329 (regulation of DNA-templated DNA replication), GO:0030174 (regulation of DNA-templated DNA replication initiation), GO:2000104 (negative regulation of DNA-templated DNA replication)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)