Protein: Large ribosomal subunit protein eL19 (60S ribosomal protein L19-A) (A0A1D8PK40)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). RPL19A may play a role in the last stages of translation initiation, in particular subunit joining and shedding/releasing factors (By similarity).
Subcellular location: Cytoplasm {ECO:0000305|PubMed:35613268}.
Sequence: MANLRTQKRLAASVIGVGKRKVWLDPNETTEIANANSRSAIRKLYKNGTIVKKPETVHSRSRARALKESKRAGRHMGYGKRKGTKDARMPSQVLWMRRLRVLRKLLAKYRDAGKIDKHLYHNLYKAAKGNTFKHKRSLVEHIIAAKAEALREKALKEEAEARRVRNRAARERRQQRLAEKKEALFAEAAN
InterPro domains: - IPR035970: Large ribosomal subunit protein eL19 superfamily (homologous_superfamily) [3-143]
- IPR000196: Large ribosomal subunit protein eL19 domain (domain) [1-149]
- IPR023638: Large ribosomal subunit protein eL19, conserved site (conserved_site) [7-26]
- IPR057259: Ribosomal protein L19e, N-terminal domain (domain) [3-54]
- IPR033935: Large ribosomal subunit protein eL19, eukaryotic (domain) [4-158]
- IPR057260: Ribosomal protein L19e, C-terminal domain (domain) [57-145]
- IPR039547: Large ribosomal subunit protein eL19 (family) [1-187]
- IPR015972: Large ribosomal subunit protein eL19, domain 1 (homologous_superfamily) [2-56]
Interaction partners: - Large ribosomal subunit protein uL14
- Small ribosomal subunit protein uS11
- Large ribosomal subunit protein uL30
- Small ribosomal subunit protein eS6
- Large ribosomal subunit protein eL31
- Small ribosomal subunit protein eS12
- Small ribosomal subunit protein eS17
- Large ribosomal subunit protein uL1
- Small ribosomal subunit protein eS28
- Large ribosomal subunit protein uL13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0003735 (structural constituent of ribosome)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process), GO:0002181 (cytoplasmic translation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)