Protein: Syndecan-3 (SYND3) (O75056)
Organism: Homo sapiens (Human)
Function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence: MKPGPPHRAGAAHGAGAGAGAAAGPGARGLLLPPLLLLLLAGRAAGAQRWRSENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA
InterPro domains: - IPR001050: Syndecan (family) [35-442]
- IPR027789: Syndecan/Neurexin domain (domain) [378-440]
- IPR030479: Syndecan, conserved site (conserved_site) [409-419]
- IPR003585: Neurexin/syndecan/glycophorin C (domain) [408-426]
Interaction partners: - Pleiotrophin
- Src substrate cortactin
- Glial cell line-derived neurotrophic factor
- Proto-oncogene tyrosine-protein kinase Src
- Fibroblast growth factor 2
- Syndecan-1
- Syndecan-2
- Inter-alpha-trypsin inhibitor heavy chain H4
- Neurturin
- Artemin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0048870 (cell motility), GO:0007155 (cell adhesion), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:1903829 (positive regulation of protein localization), GO:0009888 (tissue development), GO:0098609 (cell-cell adhesion), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060341 (regulation of cellular localization), GO:0030155 (regulation of cell adhesion), GO:0051130 (positive regulation of cellular component organization), GO:0045785 (positive regulation of cell adhesion), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0016477 (cell migration), GO:1901890 (positive regulation of cell junction assembly), GO:0010811 (positive regulation of cell-substrate adhesion), GO:0010810 (regulation of cell-substrate adhesion), GO:1901888 (regulation of cell junction assembly), GO:0032880 (regulation of protein localization), GO:0060429 (epithelium development), GO:0150116 (regulation of cell-substrate junction organization), GO:0001667 (ameboidal-type cell migration), GO:0030855 (epithelial cell differentiation), GO:1900024 (regulation of substrate adhesion-dependent cell spreading), GO:1905475 (regulation of protein localization to membrane), GO:0090109 (regulation of cell-substrate junction assembly), GO:0001954 (positive regulation of cell-matrix adhesion), GO:0001952 (regulation of cell-matrix adhesion), GO:0051893 (regulation of focal adhesion assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0005796 (Golgi lumen)