Protein: T-box transcription factor T (Brachyury protein) (Protein T) (P20293)
Organism: Mus musculus (Mouse)
Function: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site.
Subcellular location: Nucleus {ECO:0000269|PubMed:7588606}.
Sequence: MSSPGTESAGKSLQYRVDHLLSAVESELQAGSEKGDPTERELRVGLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVTADNHRWKYVNGEWVPGGKPEPQAPSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNDHKDVMEEPGDCQQPGYSQWGWLVPGAGTLCPPASSHPQFGGSLSLPSTHGCERYPALRNHRSSPYPSPYAHRNSSPTYADNSSACLSMLQSHDNWSSLGVPGHTSMLPVSHNASPPTGSSQYPSLWSVSNGTITPGSQTAGVSNGLGAQFFRGSPAHYTPLTHTVSAATSSSSGSPMYEGAATVTDISDSQYDTAQSLLIASWTPVSPPSM
InterPro domains: - IPR002070: Transcription factor, Brachyury (family) [19-291]
- IPR046360: T-box transcription factor, DNA-binding domain (domain) [41-224]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [42-223]
- IPR001699: T-box transcription factor (family) [24-401]
- IPR036960: T-box superfamily (homologous_superfamily) [40-230]
- IPR018186: Transcription factor, T-box, conserved site (conserved_site) [51-143]
Interaction partners: - Eomesodermin homolog
- Bone morphogenetic protein 4
- Homeobox protein MIXL1
- Homeobox protein notochord
- Zinc finger protein SNAI1
- T-box transcription factor TBX6
- Hepatocyte nuclear factor 3-beta
- Delta-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0097159 (organic cyclic compound binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0003676 (nucleic acid binding), GO:0001216 (DNA-binding transcription activator activity), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific), GO:0140297 (DNA-binding transcription factor binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0048771 (tissue remodeling), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0003170 (heart valve development), GO:0006725 (cellular aromatic compound metabolic process), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:1904888 (cranial skeletal system development), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:0048736 (appendage development), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009799 (specification of symmetry), GO:0044249 (cellular biosynthetic process), GO:0003188 (heart valve formation), GO:0035107 (appendage morphogenesis), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0001704 (formation of primary germ layer), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0003179 (heart valve morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0060562 (epithelial tube morphogenesis), GO:0055123 (digestive system development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048701 (embryonic cranial skeleton morphogenesis), GO:0007369 (gastrulation), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0010468 (regulation of gene expression), GO:1905314 (semi-lunar valve development), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0042692 (muscle cell differentiation), GO:0035050 (embryonic heart tube development), GO:0090304 (nucleic acid metabolic process), GO:0072359 (circulatory system development), GO:0018130 (heterocycle biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0007507 (heart development), GO:0003171 (atrioventricular valve development), GO:0048562 (embryonic organ morphogenesis), GO:0019438 (aromatic compound biosynthetic process), GO:0001707 (mesoderm formation), GO:0035108 (limb morphogenesis), GO:0070986 (left/right axis specification), GO:0060795 (cell fate commitment involved in formation of primary germ layer), GO:0048546 (digestive tract morphogenesis), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0009855 (determination of bilateral symmetry), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0060972 (left/right pattern formation), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0048332 (mesoderm morphogenesis), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0060173 (limb development), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0035113 (embryonic appendage morphogenesis), GO:0007498 (mesoderm development), GO:0060429 (epithelium development), GO:0035051 (cardiocyte differentiation), GO:0048565 (digestive tract development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0003181 (atrioventricular valve morphogenesis), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0016070 (RNA metabolic process), GO:0014706 (striated muscle tissue development), GO:2001141 (regulation of RNA biosynthetic process), GO:0001947 (heart looping), GO:0055007 (cardiac muscle cell differentiation), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0030326 (embryonic limb morphogenesis), GO:0048738 (cardiac muscle tissue development), GO:0006355 (regulation of DNA-templated transcription), GO:0055013 (cardiac muscle cell development), GO:0001947 (heart looping), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0035115 (embryonic forelimb morphogenesis), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0006366 (transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005694 (chromosome), GO:0005634 (nucleus)