Protein: rRNA biogenesis protein RRP5 (AtRrp5) (Ribosomal RNA-processing protein 5) (F4J8K6)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in the biogenesis of ribosomal RNA (rRNA). Required for the formation of 5.8S rRNA. Required for normal development of female gametophytes.
Subcellular location: Nucleus, nucleolus {ECO:0000269|PubMed:23382868}.
Sequence: MVVPQKKFANGKRNDSTKSFKPMKKPFKKTKDDVAARSEAMALQLEDVPDFPRGGGTSLSKKEREKLYEEVDAEFDADERVSKKSKGGKSKKRIPSDLDDLGLLFGGGLHGKRPRYANKITTKNISPGMKLLGVVTEVNQKDIVISLPGGLRGLVRASEVSDFTDRGIEDDENELLGDIFSVGQLVPCIVLELDDDKKEAGKRKIWLSLRLSLLHKGFSFDSFQLGMVFSANVKSIEDHGSILHFGLPSITGFIEISDDGNQESGMKTGQLIQGVVTKIDRDRKIVHLSSDPDSVAKCLTKDLSGMSFDLLIPGMMVNARVQSVLENGILFDFLTYFNGTVDLFHLKNPLSNKSWKDEYNQNKTVNARILFIDPSSRAVGLTLSPHVVCNKAPPLHVFSGDIFDEAKVVRIDKSGLLLELPSKPTPTPAYVSTYDAAGDEVTKLEKKFKEGNHIRVRVLGLKQMEGLAVGTLKESAFEGPVFTHSDVKPGMVTKAKVISVDTFGAIVQFSGGLKAMCPLRHMSEFEVTKPRKKFKVGAELVFRVLGCKSKRITVTYKKTLVKSKLPILSSYTDATEGLVTHGWITKIEKHGCFVRFYNGVQGFVPRFELGLEPGSDPDSVFHVGEVVKCRVTSAVHGTQRITLSFMIKPSSVSEDDSIKLGSIVSGIIDTITSQAVIVRVKSKSVVKGTISAEHLADHHEQAKLIMSLLRPGYELDKLLVLDIEGNNMALSSKYSLIKLAEELPSDFNQLQPNSVVHGYVCNLIENGCFVRFLGRLTGFAPRSKAIDDPKADVSESFFVGQSVRANIVDVNQEKSRITLSLKQSSCASVDASFVQEYFLMDEKISDLQSSDITKSDCSWVEKFSIGSLIKGTIQEQNDLGVVVNFDNINNVLGFIPQHHMGGATLVPGSVVNAVVLDISRAERLVDLSLRPELLNNLTKEVSNSSKKKRKRGISKELEVHQRVSAVVEIVKEQHLVLSIPEHGYTIGYASVSDYNTQKLPVKQFSTGQSVVASVKAVQNPLTSGRLLLLLDSVSGTSETSRSKRAKKKSSCEVGSVVHAEITEIKPFELRVNFGNSFRGRIHITEVNDASTSDEPFAKFRVGQSISARVVAKPCHTDIKKTQLWELSVKPAMLKDSSEFNDTQESEQLEFAAGQCVIGYVYKVDKEWVWLAVSRNVTARIFILDTSCKAHELEEFERRFPIGKAVSGYVLTYNKEKKTLRLVQRPLLFIHKSIANGGGSKTDKPDSSIPGDDDTLFIHEGDILGGRISKILPGVGGLRVQLGPYVFGRVHFTEINDSWVPDPLDGFREGQFVKCKVLEISSSSKGTWQIELSLRTSLDGMSSADHLSEDLKNNDNVCKRFERIEDLSPDMGVQGYVKNTMSKGCFIILSRTVEAKVRLSNLCDTFVKEPEKEFPVGKLVTGRVLNVEPLSKRIEVTLKTVNAGGRPKSESYDLKKLHVGDMISGRIRRVEPFGLFIDIDQTGMVGLCHISQLSDDRMENVQARYKAGESVRAKILKLDEEKKRISLGMKSSYLMNGDDDKAQPLSEDNTSMECDPINDPKSEVLAAVDDFGFQETSGGTSLVLAQVESRASIPPLEVDLDDIEETDFDSSQNQEKLLGANKDEKSKRREKQKDKEEREKKIQAAEGRLLEHHAPENADEFEKLVRSSPNSSFVWIKYMAFMLSLADIEKARSIAERALRTINIREEEEKLNIWVAYFNLENEHGNPPEESVKKVFERARQYCDPKKVYLALLGVYERTEQYKLADKLLDEMIKKFKQSCKIWLRKIQSSLKQNEEAIQSVVNRALLCLPRHKHIKFISQTAILEFKCGVADRGRSLFEGVLREYPKRTDLWSVYLDQEIRLGEDDVIRSLFERAISLSLPPKKMKFLFKKFLEYEKSVGDEERVEYVKQRAMEYANSTLA
InterPro domains: - IPR003107: HAT (Half-A-TPR) repeat (repeat) [1652-1897]
- IPR011990: Tetratricopeptide-like helical domain superfamily (homologous_superfamily) [1623-1919]
- IPR057302: Rrp5, S1 domain (domain) [126-1435]
- IPR057301: Rrp5, OB-fold domain 4 (domain) [392-482]
- IPR048058: rRNA biogenesis protein RRP5, S1 domain, eleventh repeat (domain) [1054-1122]
- IPR003029: S1 domain (domain) [126-1529]
- IPR045209: rRNA biogenesis protein Rrp5 (family) [46-1917]
- IPR057300: Rrp5, OB-fold domain (domain) [945-1032]
- IPR008847: Suppressor of forked (domain) [1819-1915]
- IPR048059: rRNA biogenesis protein RRP5, S1 domain, first repeat (domain) [125-215]
- IPR012340: Nucleic acid-binding, OB-fold (homologous_superfamily) [115-1541]
Interaction partners: - Protein NUCLEOLAR COMPLEX ASSOCIATED 4
- U3 small nucleolar RNA-associated protein 18 homolog
- AT3g56990/F24I3_70
- At3g57000
- Probable U3 small nucleolar RNA-associated protein 11
- Transducin family protein / WD-40 repeat family protein
- Uncharacterized protein At3g06530
- Protein SLOW WALKER 1
- Nucleolar protein
- ATP-dependent RNA helicase DEAH13
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0009892 (negative regulation of metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0006325 (chromatin organization), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0040029 (epigenetic regulation of gene expression), GO:0006338 (chromatin remodeling), GO:0016070 (RNA metabolic process), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0031047 (RNA-mediated gene silencing), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0031507 (heterochromatin formation), GO:0070828 (heterochromatin organization), GO:0034660 (ncRNA metabolic process), GO:0080188 (gene silencing by RNA-directed DNA methylation), GO:0140718 (facultative heterochromatin formation), GO:0030422 (siRNA processing), GO:0006346 (DNA methylation-dependent heterochromatin formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)