Protein: Prickle-like protein 2 (Q80Y24)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Nucleus membrane {ECO:0000305}.
Sequence: MVTVMPLEMEKTISKLMFDFQRSSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSAGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQIKGGDIAVFASRAGHGICWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKNKGKTEEAMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNRDPIWRSREEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQGAGAQPDMWAKHFSNPKRSSSMALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFNETRGSIPVPKYEEEEEEEEGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPLGYRDLQSHGRMHQSFDFDGGIASSKLPGQEGVHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHLASEREVIARLKERPPLRAREDYDQFMRQRSFQESLGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCIIS
InterPro domains: - IPR033726: LIM2 prickle (domain) [193-248]
- IPR033727: LIM3 prickle (domain) [253-311]
- IPR033725: LIM1 prickle (domain) [130-188]
- IPR010442: PET domain (domain) [18-126]
- IPR033723: PET prickle (domain) [26-122]
- IPR047120: Prickle/Espinas/Testin (family) [6-324]
- IPR001781: Zinc finger, LIM-type (domain) [128-309]
Interaction partners: - Vang-like protein 2
- Segment polarity protein dishevelled homolog DVL-1
- Vang-like protein 1
- Segment polarity protein dishevelled homolog DVL-2
- Segment polarity protein dishevelled homolog DVL-3
- Ankyrin repeat domain-containing protein 6
- Cadherin EGF LAG seven-pass G-type receptor 1
- Frizzled-6
- Disks large homolog 4
- Inversin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0048870 (cell motility), GO:0007163 (establishment or maintenance of cell polarity), GO:0007389 (pattern specification process), GO:0022402 (cell cycle process), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0007267 (cell-cell signaling), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0016049 (cell growth), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0035264 (multicellular organism growth), GO:0032941 (secretion by tissue), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0007155 (cell adhesion), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0001503 (ossification), GO:0140352 (export from cell), GO:0007017 (microtubule-based process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0051602 (response to electrical stimulus), GO:0012501 (programmed cell death), GO:0048729 (tissue morphogenesis), GO:0030010 (establishment of cell polarity), GO:0035148 (tube formation), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0007051 (spindle organization), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0045184 (establishment of protein localization), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0009887 (animal organ morphogenesis), GO:0050878 (regulation of body fluid levels), GO:0046907 (intracellular transport), GO:0061303 (cornea development in camera-type eye), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0032940 (secretion by cell), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0030282 (bone mineralization), GO:0060323 (head morphogenesis), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0048736 (appendage development), GO:0010171 (body morphogenesis), GO:0009798 (axis specification), GO:1903047 (mitotic cell cycle process), GO:0198738 (cell-cell signaling by wnt), GO:0098609 (cell-cell adhesion), GO:0001568 (blood vessel development), GO:1905114 (cell surface receptor signaling pathway involved in cell-cell signaling), GO:0051649 (establishment of localization in cell), GO:0035107 (appendage morphogenesis), GO:0000226 (microtubule cytoskeleton organization), GO:0036342 (post-anal tail morphogenesis), GO:0043170 (macromolecule metabolic process), GO:0060249 (anatomical structure homeostasis), GO:0003151 (outflow tract morphogenesis), GO:0061061 (muscle structure development), GO:0007059 (chromosome segregation), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0060324 (face development), GO:0060322 (head development), GO:0060325 (face morphogenesis), GO:0016358 (dendrite development), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0001894 (tissue homeostasis), GO:0000278 (mitotic cell cycle), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0042733 (embryonic digit morphogenesis), GO:0048880 (sensory system development), GO:0016055 (Wnt signaling pathway), GO:0001944 (vasculature development), GO:0032990 (cell part morphogenesis), GO:0030705 (cytoskeleton-dependent intracellular transport), GO:0007369 (gastrulation), GO:0002009 (morphogenesis of an epithelium), GO:0007052 (mitotic spindle organization), GO:0003401 (axis elongation), GO:0016331 (morphogenesis of embryonic epithelium), GO:0048666 (neuron development), GO:0060976 (coronary vasculature development), GO:0009948 (anterior/posterior axis specification), GO:0022607 (cellular component assembly), GO:0051225 (spindle assembly), GO:0048568 (embryonic organ development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0061326 (renal tubule development), GO:0003007 (heart morphogenesis), GO:0007399 (nervous system development), GO:0043062 (extracellular structure organization), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:2000027 (regulation of animal organ morphogenesis), GO:1990138 (neuron projection extension), GO:0048858 (cell projection morphogenesis), GO:0010467 (gene expression), GO:0022411 (cellular component disassembly), GO:0007507 (heart development), GO:0060840 (artery development), GO:0072001 (renal system development), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:0055006 (cardiac cell development), GO:0098813 (nuclear chromosome segregation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0021915 (neural tube development), GO:0055001 (muscle cell development), GO:0140014 (mitotic nuclear division), GO:0007423 (sensory organ development), GO:0046903 (secretion), GO:0060485 (mesenchyme development), GO:0045229 (external encapsulating structure organization), GO:0035108 (limb morphogenesis), GO:0072175 (epithelial tube formation), GO:0022008 (neurogenesis), GO:0007589 (body fluid secretion), GO:0060537 (muscle tissue development), GO:0006915 (apoptotic process), GO:0060606 (tube closure), GO:0031214 (biomineral tissue development), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0000070 (mitotic sister chromatid segregation), GO:0034330 (cell junction organization), GO:0035051 (cardiocyte differentiation), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0009792 (embryo development ending in birth or egg hatching), GO:0001838 (embryonic epithelial tube formation), GO:0014706 (striated muscle tissue development), GO:1990403 (embryonic brain development), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0085029 (extracellular matrix assembly), GO:0001843 (neural tube closure), GO:0150063 (visual system development), GO:0007010 (cytoskeleton organization), GO:0090175 (regulation of establishment of planar polarity), GO:0055007 (cardiac muscle cell differentiation), GO:0030198 (extracellular matrix organization), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0001841 (neural tube formation), GO:0048699 (generation of neurons), GO:0030326 (embryonic limb morphogenesis), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0035567 (non-canonical Wnt signaling pathway), GO:0043009 (chordate embryonic development), GO:0001654 (eye development), GO:0001702 (gastrulation with mouth forming second), GO:0048738 (cardiac muscle tissue development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0055013 (cardiac muscle cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0031254 (cell trailing edge), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0140535 (intracellular protein-containing complex), GO:1905368 (peptidase complex), GO:0043229 (intracellular organelle), GO:0000502 (proteasome complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:1905369 (endopeptidase complex), GO:0005634 (nucleus)