Protein: Glutathione S-transferase (EC 2.5.1.18) (GST class-pi) (C7DJS2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|RuleBase:RU368105}. Mitochondrion {ECO:0000256|RuleBase:RU368105}. Nucleus {ECO:0000256|RuleBase:RU368105}.
Sequence: QDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYVSLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGN
InterPro domains: - IPR003082: Glutathione S-transferase, Pi class (family) [44-151]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [23-150]
- IPR050213: Glutathione S-transferase superfamily (family) [2-140]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [42-140]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [27-148]
- IPR040079: Glutathione transferase family (family) [2-131]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [1-25]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016209 (antioxidant activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:0008289 (lipid binding), GO:0004601 (peroxidase activity), GO:1901681 (sulfur compound binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0004602 (glutathione peroxidase activity), GO:0005504 (fatty acid binding), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0043177 (organic acid binding), GO:0016684 (oxidoreductase activity, acting on peroxide as acceptor), GO:0043168 (anion binding), GO:0004364 (glutathione transferase activity), GO:0031406 (carboxylic acid binding), GO:0033293 (monocarboxylic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0009058 (biosynthetic process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0065009 (regulation of molecular function), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0060759 (regulation of response to cytokine stimulus), GO:0009968 (negative regulation of signal transduction), GO:0060548 (negative regulation of cell death), GO:0009410 (response to xenobiotic stimulus), GO:0120254 (olefinic compound metabolic process), GO:0080134 (regulation of response to stress), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006805 (xenobiotic metabolic process), GO:0060761 (negative regulation of response to cytokine stimulus), GO:0001817 (regulation of cytokine production), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006749 (glutathione metabolic process), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044092 (negative regulation of molecular function), GO:0080135 (regulation of cellular response to stress), GO:0044249 (cellular biosynthetic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0001818 (negative regulation of cytokine production), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0032682 (negative regulation of chemokine production), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0032642 (regulation of chemokine production), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043436 (oxoacid metabolic process), GO:0070302 (regulation of stress-activated protein kinase signaling cascade), GO:0010468 (regulation of gene expression), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006631 (fatty acid metabolic process), GO:0007399 (nervous system development), GO:0016053 (organic acid biosynthetic process), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0007417 (central nervous system development), GO:0001960 (negative regulation of cytokine-mediated signaling pathway), GO:1903556 (negative regulation of tumor necrosis factor superfamily cytokine production), GO:0008610 (lipid biosynthetic process), GO:0010629 (negative regulation of gene expression), GO:0043651 (linoleic acid metabolic process), GO:0043086 (negative regulation of catalytic activity), GO:0071466 (cellular response to xenobiotic stimulus), GO:0051248 (negative regulation of protein metabolic process), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:1902532 (negative regulation of intracellular signal transduction), GO:0032652 (regulation of interleukin-1 production), GO:2001233 (regulation of apoptotic signaling pathway), GO:0044272 (sulfur compound biosynthetic process), GO:0032692 (negative regulation of interleukin-1 production), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0051338 (regulation of transferase activity), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0031400 (negative regulation of protein modification process), GO:0032691 (negative regulation of interleukin-1 beta production), GO:0032651 (regulation of interleukin-1 beta production), GO:0019752 (carboxylic acid metabolic process), GO:0006633 (fatty acid biosynthetic process), GO:0043549 (regulation of kinase activity), GO:0032720 (negative regulation of tumor necrosis factor production), GO:0051348 (negative regulation of transferase activity), GO:0051769 (regulation of nitric-oxide synthase biosynthetic process), GO:0070303 (negative regulation of stress-activated protein kinase signaling cascade), GO:0001676 (long-chain fatty acid metabolic process), GO:0032872 (regulation of stress-activated MAPK cascade), GO:0043409 (negative regulation of MAPK cascade), GO:0043408 (regulation of MAPK cascade), GO:0031399 (regulation of protein modification process), GO:0043066 (negative regulation of apoptotic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0071637 (regulation of monocyte chemotactic protein-1 production), GO:0019220 (regulation of phosphate metabolic process), GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway), GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:0032680 (regulation of tumor necrosis factor production), GO:0033559 (unsaturated fatty acid metabolic process), GO:0010804 (negative regulation of tumor necrosis factor-mediated signaling pathway), GO:0045936 (negative regulation of phosphate metabolic process), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0032787 (monocarboxylic acid metabolic process), GO:0006692 (prostanoid metabolic process), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0032873 (negative regulation of stress-activated MAPK cascade), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0046328 (regulation of JNK cascade), GO:0042759 (long-chain fatty acid biosynthetic process), GO:0006690 (icosanoid metabolic process), GO:0033673 (negative regulation of kinase activity), GO:0043407 (negative regulation of MAP kinase activity), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0046329 (negative regulation of JNK cascade), GO:0006693 (prostaglandin metabolic process), GO:0043508 (negative regulation of JUN kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071901 (negative regulation of protein serine/threonine kinase activity), GO:0043506 (regulation of JUN kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)