Protein: Ribosomal protein uL16-like (60S ribosomal protein L10-like) (Large ribosomal subunit protein uL16-like) (Q96L21)
Organism: Homo sapiens (Human)
Function: Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680, ECO:0000305|PubMed:32669547}.
Sequence: MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQLSSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
InterPro domains: - IPR001197: Large ribosomal subunit protein uL16, eukaryotes/archaea (family) [1-213]
- IPR047873: Large ribosomal subunit protein uL16 (family) [12-165]
- IPR018255: Large ribosomal subunit protein uL16, conserved site, eukaryotes/archaea (conserved_site) [108-129]
- IPR016180: Large ribosomal subunit protein uL16 domain (domain) [41-165]
- IPR036920: Large ribosomal subunit protein uL16 superfamily (homologous_superfamily) [1-174]
Interaction partners: - Small ribosomal subunit protein RACK1
- Large ribosomal subunit protein eL24
- Small ribosomal subunit protein eS8
- Small ribosomal subunit protein uS5
- Large ribosomal subunit protein eL30
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL15
- Small ribosomal subunit protein uS2
- Large ribosomal subunit protein uL18
- Large ribosomal subunit protein eL18
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0045182 (translation regulator activity), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0003735 (structural constituent of ribosome), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0060548 (negative regulation of cell death), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010941 (regulation of cell death), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009790 (embryo development), GO:0009890 (negative regulation of biosynthetic process), GO:0043603 (amide metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043604 (amide biosynthetic process), GO:0010468 (regulation of gene expression), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0048568 (embryonic organ development), GO:0034248 (regulation of amide metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0010467 (gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0042981 (regulation of apoptotic process), GO:0043043 (peptide biosynthetic process), GO:1990403 (embryonic brain development), GO:0043066 (negative regulation of apoptotic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0002181 (cytoplasmic translation), GO:0006355 (regulation of DNA-templated transcription), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0010608 (post-transcriptional regulation of gene expression), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)