Protein: MAGUK p55 subfamily member 7 (Q5T2T1)
Organism: Homo sapiens (Human)
Function: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
Subcellular location: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:17332497}. Lateral cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:17332497}. Cell junction, tight junction {ECO:0000269|PubMed:17237226, ECO:0000269|PubMed:17332497}. Cell junction, adherens junction {ECO:0000269|PubMed:17237226, ECO:0000269|PubMed:17332497}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:26481050}. Note=In epidermal cells, detected primarily at the lateral cell membrane. {ECO:0000269|PubMed:17332497}.
Sequence: MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [115-222]
- IPR008144: Guanylate kinase-like domain (domain) [368-560]
- IPR036892: L27 domain superfamily (homologous_superfamily) [71-122]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [204-350]
- IPR001452: SH3 domain (domain) [228-298]
- IPR035599: MPP7, SH3 domain (domain) [232-292]
- IPR020590: Guanylate kinase, conserved site (conserved_site) [403-420]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [358-575]
- IPR014775: L27 domain, C-terminal (domain) [16-124]
- IPR050716: Membrane-associated guanylate kinase (family) [13-574]
- IPR008145: Guanylate kinase/L-type calcium channel beta subunit (domain) [367-563]
- IPR001478: PDZ domain (domain) [139-220]
- IPR004172: L27 domain (domain) [10-125]
Interaction partners: - Protein lin-7 homolog C
- Protein lin-7 homolog A
- Disks large homolog 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0007275 (multicellular organism development), GO:0007272 (ensheathment of neurons), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0008366 (axon ensheathment), GO:0051668 (localization within membrane), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0007417 (central nervous system development), GO:0008104 (protein localization), GO:0007399 (nervous system development), GO:0042552 (myelination), GO:0061024 (membrane organization), GO:0045176 (apical protein localization), GO:0031579 (membrane raft organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton)