wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Mitochondrial import inner membrane translocase subunit TIM50 (Q586S5)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein {ECO:0000256|RuleBase:RU365079}.
Sequence: MYGRCLHRLSRSAPGVLGRQWQSAFPQGTSTKGGTNTDAHIFTRSASPIHMYANKENAWKDYTDDRFYGAKRMKEYWVRMMYDRGARYYVLATLVAIMLAGSKLWSLQEKQKRLLGLIGPKKKNYRSRLTVVLDVDETIVSYGDKAFRMKAGLVPRPYLAELLDYLSFIDAEVVLWSACSERYMQQVLNVIDPSGIRVSQCIVRNRDWFTGDNYYEKNILWLKRPLEDTLIVENRPLSVRNCNANAILVDDFIRAEYMDTGKDYPSNDNALRTLKAIIQDLHESGLPVKEYLADAKRRNKDIKEIPCHLAFRQLPDELARGVFYFIGEKYKHSSAS
InterPro domains: - IPR004274: FCP1 homology domain (domain) [124-282]
- IPR023214: HAD superfamily (homologous_superfamily) [116-306]
- IPR050365: Mitochondrial import inner membrane translocase subunit TIM50 (family) [72-283]
- IPR036412: HAD-like superfamily (homologous_superfamily) [120-282]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0004721 (phosphoprotein phosphatase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0004722 (protein serine/threonine phosphatase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016311 (dephosphorylation), GO:0006470 (protein dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ELAV-like protein 4 (Protein elrD) (A0A0R4IEW8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (By similarity). Plays a role in the regulation of mRNA stability, alternative splicing and translation (By similarity). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Mainly plays a role in neuron-specific RNA processing (By similarity). Required for the maturation of motor neuron axonal branches and dendrites.
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:O09032}. Perikaryon {ECO:0000250|UniProtKB:Q61701}. Cell projection, axon {ECO:0000250|UniProtKB:Q61701}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61701}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q61701}.
Sequence: MFEISRTLNAALLSNEGSTETQWRQADLPQLQGWAEKGLLTQPKMIISNMEPQVTNGPNSATANGPSSNSRSCPSPMQTGGSNDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGPTGGSRGVGFIRFDKRIEAEEAIKGLNGQKPSGAAEPITVKFANNPSQKTSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDSMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKS
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [61-408]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [48-411]
- IPR034918: HuD, RNA recognition motif 3 (domain) [325-410]
- IPR002343: Paraneoplastic encephalomyelitis antigen (family) [88-255]
- IPR000504: RNA recognition motif domain (domain) [88-406]
- IPR006548: Splicing factor ELAV/Hu (family) [85-410]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0045595 (regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0051960 (regulation of nervous system development), GO:0060284 (regulation of cell development), GO:0050767 (regulation of neurogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005938 (cell cortex)
Protein: Stevor (Q8IBE5)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MNMYYLNMLLFTFLINTLVLPHYENYLNNHYNVGLIQNNTKRATINSRLLAQTKNHNPHYHNDPELKEIIDKMNEEAIKKYQQTHDPYKQLKDVVEKNGTKYTGGKDAEPMSTLEKELLETYEEMFGNESDMLKSGMSPNVDEKSSTCECTDINGVKLAKTKGRDKYLKHLKHRCIGGICSCTLGSALLTYIGTVAAKAAIIAKFAEVPKNCITSISILHMLTYDSMSSAIKSVGTAVCVADLAGEATTVSAIFVPCGIAALVLLILAVVLIILYIWLYRRRKNSWKHECKKHLCK
InterPro domains: - IPR006374: Variant surface antigen Stevor (family) [1-296]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0044403 (biological process involved in symbiotic interaction), GO:0035821 (modulation of process of another organism), GO:0044068 (modulation by symbiont of host cellular process), GO:0051701 (biological process involved in interaction with host), GO:0020013 (modulation by symbiont of host erythrocyte aggregation), GO:0044003 (modulation by symbiont of host process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0030430 (host cell cytoplasm), GO:0033655 (host cell cytoplasm part), GO:0020036 (Maurer's cleft)
Protein: Myosin regulatory light polypeptide 9 (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Q5E9E2)
Organism: Bos taurus (Bovine)
Function: Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9CQ19}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9CQ19}. Note=Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. {ECO:0000250|UniProtKB:Q9CQ19}.
Sequence: MSSKRAKTKTTKKRPQRATSNVFAMFDQSQIQEFKEAFNMIDQNRDGFIDKEDLHDMLASLGKNPTDEYLDAMMNEAPGPINFTMFLTMFGEKLNGTDPEDVIRNAFACFDEEATGTIQEDYLRELLTTMGDRFTDEEVDELYREAPIDKKGNFNYIEFTRILKHGAKDKDD
InterPro domains: - IPR015070: DJBP, EF-hand domain (domain) [102-160]
- IPR011992: EF-hand domain pair (homologous_superfamily) [26-165]
- IPR002048: EF-hand domain (domain) [29-133]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [42-54]
- IPR050403: Myosin regulatory light chain (family) [1-170]
Interaction partners: - Myosin-10
- Myosin-9
- Myosin light chain kinase, smooth muscle
- Myosin-11
- Myosin light polypeptide 6
- Myosin light chain 6B
- Myosin light chain kinase 3
- Myosin light chain kinase 2, skeletal/cardiac muscle
- Rho-associated protein kinase 2
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050817 (coagulation), GO:0065008 (regulation of biological quality), GO:0001775 (cell activation), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0007155 (cell adhesion), GO:0030168 (platelet activation), GO:0050878 (regulation of body fluid levels), GO:0007596 (blood coagulation), GO:0009611 (response to wounding), GO:0098609 (cell-cell adhesion), GO:0044057 (regulation of system process), GO:0042060 (wound healing), GO:0090257 (regulation of muscle system process), GO:0007599 (hemostasis), GO:0034109 (homotypic cell-cell adhesion), GO:0070527 (platelet aggregation), GO:0006937 (regulation of muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043292 (contractile fiber), GO:0043228 (non-membrane-bounded organelle), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber)
Protein: P0 (Q65967)
Organism: Cucurbit aphid-borne yellows virus
Function: Not known
Sequence: MQIESVKQQLIFRPTRRTSINDRKLNVANFLINHSFFLAINGTNLLRLFLARLPLLISEQLSGDYVYTPGASKRIILARFHRHCGAPLPSSSAVDLRLPASKDVARFFLARHYSRALGERIQRNQTSLFRGYAEFAKFINVWCSSISHRLGEFTPRNFTNGSIFVDLSNLGHSLCDLVLAQQVHDRDAYTRLALHIHRIYGEDGGLDFWRLANFPSKSWPFNGERCLEGSVVQKELQR
InterPro domains: - IPR006755: Suppressor of silencing P0 (family) [10-207]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0019068 (virion assembly), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0030430 (host cell cytoplasm), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Toucan, isoform I (M9PC13)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MLAIVILMTGGVGVCINPNRSDQKTAFKVVATSVKGGRSYSKDSHKSSHTDLSLMCNASSSRPSNSASGSGSPKLLANTQLHKRLNGTLASTAAIATPIKGVATKSGATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKELDAVACKENKHQCARTKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLKFCELESQLRAKDEESKQAQEAYRMEVSHKLALKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVLELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVMKGMIERNDSVSWTLEIEDESFKGNTSKIVRRAGSLRSNNERCPIQRRQTLTSNGHSNGSATNGGSSPAHPNPLSQSMSATALLRSSSNSGESEGRPLSRARSKSMCIKASATSSAVCESSGQRKKPQDELSLADWPEDIPLCSSSPQAPGIEMRPRSSTMKLMSSEAKKFQEIQESAGEAMVSGANSEDESCSASSEDIMRSSSASSTASGGSLSKRPKQPPSRMSIEEALPCTPMEVSWSEDAADANGLA
InterPro domains: - IPR051293: Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69 (family) [37-769]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0007049 (cell cycle), GO:0009790 (embryo development), GO:0000278 (mitotic cell cycle), GO:0033301 (cell cycle comprising mitosis without cytokinesis), GO:0045448 (mitotic cell cycle, embryonic), GO:0035186 (syncytial blastoderm mitotic cell cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0030496 (midbody), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0000922 (spindle pole), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0031965 (nuclear membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)
Protein: Histone deacetylase/AcuC/AphA family protein (Q7MMB6)
Organism: Vibrio vulnificus (strain YJ016)
Function: Not known
Sequence: MMSIPLIYHPIYSRLPLPEGHRYPIMKYHHLYQAVCRYQQQHLEWQQAFAFYQPEALSIEAIKQVHQQEYVDLLTTGLLPAAKMRRIGFPWSEQLIERTLTSTAGTVLTAEKALQHGVAIHLSGGYHHAHFDYGSGFCLFNDLVMAAHKALEHASVDKVLIIDSDVHHGDGTATLCQRRDDIVTLSFHCDKNFPARKPDSDLDIGLPRECGDEAFLAAFKEVVPMAIRLHQPDLIIYDAGVDIHHEDELGYLNVSTDALYQRDAFLFGQAKASAIPVAAVVGGGYRTDHEALVPLHLQLLNAAFDVYRSTPD
InterPro domains: - IPR037138: Histone deacetylase domain superfamily (homologous_superfamily) [3-303]
- IPR000286: Histone deacetylase HDAC (family) [124-242]
- IPR044150: Histone deacetylase 11 (domain) [21-300]
- IPR023696: Ureohydrolase domain superfamily (homologous_superfamily) [2-295]
- IPR023801: Histone deacetylase domain (domain) [32-289]
Interaction partners: - Chaperone protein HtpG
- RNA polymerase-associated protein RapA
- Uncharacterized protein
- DNA topoisomerase 3
- NAD-dependent protein deacylase
- AnkB protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016787 (hydrolase activity), GO:0043169 (cation binding), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0033558 (protein lysine deacetylase activity), GO:0019213 (deacetylase activity), GO:0046872 (metal ion binding), GO:0016811 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0006525 (arginine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex)
Protein: GCMb (Glial cell missing-like protein) (Glial cells missing homolog 2 (Drosophila)) (Glial cells missing transcription factor 2) (Q68BU9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MSKSSDQFDSSDCVCSFGMKLTWDINDPKLPQDTKQYDAFQEWTDGYVRYIYSSEDKNAQRHLSGWAMRNTNNHNCQILKKSCLGVVVCSRNCSLPDGSKLQLRPAICDKARQKQQKKLCPNCNSALELIPCRGHSGYPVTNFWRVDGKAIFFQAKGVHDHPRPESKSETEARRSAVKRRMSSPPFSQKRRLVEPEPGRYHDMAFPNIHQLTMEGPERFSIIAESNFPIQTQHYPTFQNPEPYKFPYDTHAAAMADAQSSLQKPANHRLYVTRPPCGYDFAVPGYLGSGPYPAALYKDPSSPQMETEPNKSGSSLSGVSHGSSPLGSHERSYAESSGKHHGWKQILSKGGYGDRGDYSQLPTNANHHYYNSDYPCRYTGPAAPTPAALQTIITTTTKVSYQPCPKPSVVKYGENIYDVKGLSNCNSILEEPSPNSYSDLKIPEDSGVIKSALSYQDTLPAKIERSENFEGYRYSSYSANSYPERMSHPFRYDSGEY
InterPro domains: - IPR039791: Chorion-specific transcription factor GCM (family) [6-492]
- IPR043021: GCM, small domain (homologous_superfamily) [86-174]
- IPR036115: GCM domain superfamily (homologous_superfamily) [21-176]
- IPR043020: GCM domain, large subdomain (homologous_superfamily) [51-164]
- IPR003902: Transcription regulator GCM domain (domain) [21-176]
Interaction partners: - Forkhead box I3b.
- Forkhead box I3a.
- Forkhead box N1
- Sodium/hydrogen exchanger
- Solute carrier family 12 member 10, tandem duplicate 2
- Transient receptor potential cation channel subfamily V member 6 isoform X1
- Parathyroid hormone 1a.
- Cleavage and polyadenylation-specific factor 4.
- Anion exchange protein
- Calcium-sensing receptor.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048878 (chemical homeostasis), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0001708 (cell fate specification), GO:0050801 (monoatomic ion homeostasis), GO:0045165 (cell fate commitment), GO:0098771 (inorganic ion homeostasis), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051216 (cartilage development), GO:0030855 (epithelial cell differentiation), GO:0055080 (monoatomic cation homeostasis), GO:0060429 (epithelium development), GO:0001501 (skeletal system development), GO:0055078 (sodium ion homeostasis), GO:0008544 (epidermis development), GO:0061448 (connective tissue development), GO:0055074 (calcium ion homeostasis), GO:0009957 (epidermal cell fate specification), GO:0009913 (epidermal cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Histone H2A type 1-A (H2A-clustered histone 1) (Histone H2A/r) (Q96QV6)
Organism: Homo sapiens (Human)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus. Chromosome.
Sequence: MSGRGKQGGKARAKSKSRSSRAGLQFPVGRIHRLLRKGNYAERIGAGAPVYLAAVLEYLTAEILELAGNASRDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKKTESHHHKAQSK
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [2-131]
- IPR002119: Histone H2A (family) [3-123]
- IPR007125: Histone H2A/H2B/H3 (domain) [5-89]
- IPR032454: Histone H2A, C-terminal domain (domain) [92-125]
- IPR032458: Histone H2A conserved site (conserved_site) [22-28]
Interaction partners: - Histone H2B type 1-A
- Histone H2B type 2-E
- Histone H4
- Histone H2B type 1-C/E/F/G/I
- Histone H3.1
- Histone H1.1
- Histone deacetylase 1
- Histone deacetylase 3
- Histone deacetylase 2
- Histone H2B type 1-B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005615 (extracellular space), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)
Protein: Tetraspanin (Q1L9G6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane {ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361218}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
Sequence: MMSKSGLSSGEQCIKYIIFFFNFMLWLAGTGVLAVGLWLRFDAKTKEFFTAENGQTVFLTGVYILIVAGAVMMVVGFLGCCGAIKESACMLGLFFMFLLVIFAAEVAAGIWGLSNKDKIVSDIQQFYTQTVKNYKESPDGPLKETLTAIHFSLQCCGPTGLVTDGVSVTCPKQEGLANVITTGCSSVIQDMFNSRLHVIGGVGIGIGVIMVFGMIFSMLLCCAIRRTRDIV
InterPro domains: - IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [111-199]
- IPR000301: Tetraspanin, animals (family) [5-230]
- IPR042055: CD9, extracellular domain (domain) [113-196]
- IPR018499: Tetraspanin/Peripherin (family) [14-223]
- IPR018503: Tetraspanin, conserved site (conserved_site) [69-91]
Interaction partners: - SLAIN motif-containing protein-like
- Sidekick cell adhesion molecule 2a.
- Immunoglobulin superfamily, member 8.
- Shroom family member 2a.
- Meiotic nuclear division protein 1 homolog
- Clavesin-2
- Band 4.1-like protein 3a isoform 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0048880 (sensory system development), GO:0048882 (lateral line development), GO:0048916 (posterior lateral line development), GO:0048925 (lateral line system development), GO:0048915 (posterior lateral line system development), GO:0048881 (mechanosensory lateral line system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)