Protein: Repressor of filamentous growth 1 (Q5A220)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5
Subcellular location: Nucleus
Sequence: MSTAIYYSTHNNMHTNDDITNGSGSTTSGNPGANPSNPNHTNAGATINNNSNIGLNSANKNHTTLLPSLAHIMPSNSNNTTNSGSSIDISSTLINPYSSGAAAAAAAVGGGNGGYYHPPPPHSQQQQQQQFDTSYSNQTTPTSAYTNFNNDSTHSPTDISMQQNMNNLASSSGNMSIGGGIDGNFSHNNNNNNNNNNNNNNKCICKSKVNKIPRPRNAFILFRQKYHQMVLDEGTVIRTNPEVSRELGRRWRGLSPQEKEHWNNLAEEEKKNHAKKYPGYRYTPRRNGRNKNCPVCKNKPLPNNKSNSISGMSGSGGGGGSISGASSLSGGLTSRDNSITNANAIDYQQQQLQQQQQQQQQQAIQFQSLPPDQYQQLIKQQQQQLQLQAQLNGGGGGGGITSNPQTIPQYITNGNYPSYIISPNPYSTTSTTAPTTTTTTTTNASSIGLSVPPTATTTSTSSQPTSANSQLHFYEAEKLSPVSSTHHQSSISEIAAQQQQQQQQQQFMYNTNYSTIPPNNTTTMQQHSAGTGNDYSLNGNNSGNTGYDNRYGYGQPMIITGQSQQGLQVQQQGQHYNSGLHAAQHYQQQQQQHHQQQPPQ
InterPro domains: - IPR009071: High mobility group box domain (domain) [211-282]
- IPR036910: High mobility group box domain superfamily (homologous_superfamily) [209-299]
- IPR050140: SRY-related HMG-box transcription factor-like (family) [159-581]
Interaction partners: - Transcriptional repressor TUP1
- Transcriptional repressor TUP1
- Transcriptional regulator NRG1
- Enhanced filamentous growth protein 1
- protein disulfide-isomerase
- Transcription factor CPH1
- Transcription regulator
- Transcription activator TEC1
- Biofilm regulator 1
- SUMO-conjugating enzyme UBC9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0045927 (positive regulation of growth), GO:0044403 (biological process involved in symbiotic interaction), GO:0048522 (positive regulation of cellular process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010570 (regulation of filamentous growth), GO:0075136 (response to host), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0009268 (response to pH), GO:0090033 (positive regulation of filamentous growth), GO:0080090 (regulation of primary metabolic process), GO:0036171 (filamentous growth of a population of unicellular organisms in response to chemical stimulus), GO:0071496 (cellular response to external stimulus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:1900434 (regulation of filamentous growth of a population of unicellular organisms in response to starvation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0009267 (cellular response to starvation), GO:0036176 (response to neutral pH), GO:1900445 (positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0032104 (regulation of response to extracellular stimulus), GO:0010468 (regulation of gene expression), GO:0071467 (cellular response to pH), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0036177 (filamentous growth of a population of unicellular organisms in response to pH), GO:0031667 (response to nutrient levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0032106 (positive regulation of response to extracellular stimulus), GO:0051252 (regulation of RNA metabolic process), GO:1901701 (cellular response to oxygen-containing compound), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0034198 (cellular response to amino acid starvation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0036178 (filamentous growth of a population of unicellular organisms in response to neutral pH), GO:0032107 (regulation of response to nutrient levels), GO:1900436 (positive regulation of filamentous growth of a population of unicellular organisms in response to starvation), GO:0036244 (cellular response to neutral pH), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0046688 (response to copper ion), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:0071280 (cellular response to copper ion), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)