Protein: AP-1 complex subunit beta-1 (Beta-1-adaptin) (Clathrin assembly protein complex 1 beta-1 large chain) (Clathrin assembly protein large beta-1 chain) (P36000)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin.
Subcellular location: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.
Sequence: MPPLDKRIKKFLKDSIRIAPKISGKGELSELRTGLVSQYPQTRKDAIKKTIQQMTLGKDVSSLFPDVLKNIATIDVEQKKLVYLYVMNYAETHPELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVRKTAVICVAKLFQLNKDLCVELGVVEDLVNALDDSNPLVIANATAALIEIHNMDMDAVDLSSLIQSHVSQFLLALNECTEWARIIILGTLSEYSAKDSLEAQDIIDRVTAHLQHVNPAVVLATIKVIVRNLPQIEYSSNSLIMKRLSSAFVSLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLYVKLEKIDILVRLVDPSNLKQCTLLLTELKEYAMEYEPEFVSRAIQALSQLGIKYAQESFVSKVLDILLELLERQDTIKDDCCISLCDLLRHCPGNDKMAKQVCAVFNTWSNPEVLLQSDIAKCNYVWLLGQHPNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRLHATLTGSMLQSVLELATQQTHELDVRDMAMMYWRCLSMPNNESLVNDLCQNKLPMISNTLEKFSPEVLEKLLMELGTISSIYFKPDSNRRKGKKYVQNIVKGKHIEELESMAKNEISSKANDDVLLDFDERDDVTNTNAGMLNTLTTLGDLDDLFDFGPSEDATQINTNDTKAVQGLKELKLGGDSNGISSGGKNNPDVSGGNIVSQDLLDLF
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [26-601]
- IPR026739: AP complex subunit beta (family) [25-668]
- IPR011989: Armadillo-like helical (homologous_superfamily) [21-611]
- IPR002553: Clathrin/coatomer adaptor, adaptin-like, N-terminal (domain) [26-552]
- IPR016342: AP-1/2/4 complex subunit beta (family) [9-722]
Interaction partners: - Adaptin medium chain homolog APM2
- AP-1 complex subunit sigma-1
- AP-1 complex subunit gamma-1
- AP-1 complex subunit mu-1-I
- Clathrin heavy chain
- AP-2 complex subunit sigma
- AP-2 complex subunit mu
- AP-2 complex subunit alpha
- Clathrin light chain
- Epsin-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0030276 (clathrin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0045184 (establishment of protein localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0006886 (intracellular protein transport), GO:0016192 (vesicle-mediated transport), GO:0071705 (nitrogen compound transport), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0048193 (Golgi vesicle transport), GO:0033365 (protein localization to organelle), GO:0006623 (protein targeting to vacuole), GO:0072666 (establishment of protein localization to vacuole), GO:0006605 (protein targeting), GO:0006896 (Golgi to vacuole transport), GO:0006892 (post-Golgi vesicle-mediated transport), GO:0072665 (protein localization to vacuole)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0048475 (coated membrane), GO:0030119 (AP-type membrane coat adaptor complex), GO:0030133 (transport vesicle), GO:0005794 (Golgi apparatus), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0030118 (clathrin coat), GO:0030140 (trans-Golgi network transport vesicle), GO:0098588 (bounding membrane of organelle), GO:0030131 (clathrin adaptor complex), GO:0012506 (vesicle membrane), GO:0005798 (Golgi-associated vesicle), GO:0030130 (clathrin coat of trans-Golgi network vesicle), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0030125 (clathrin vesicle coat), GO:0012510 (trans-Golgi network transport vesicle membrane), GO:0030136 (clathrin-coated vesicle), GO:0030121 (AP-1 adaptor complex), GO:0030662 (coated vesicle membrane), GO:0030660 (Golgi-associated vesicle membrane), GO:0030665 (clathrin-coated vesicle membrane)