Protein: mitogen-activated protein kinase kinase kinase (E7F2L3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MNSDLEAISLSVPSLSQPLEMMMVMMGGSDGESSAGNNSSAGAFWQDPSNCKSANPGLISLPSDGVALLTPGKCKSRAVTVAYVRNSETSQPSSPENMALQCLKDACDIVGCKLDVVPFGKLDFGETSVLDHFYNADIAVVELTDAFRQPSLFYHLGVRESFCMVNNIILYCDHNSDSLQSLQDLICQKNMTCAANYTFIPYMVTPQSKVYCCESSLMKGLSELMQPSFEALLGPICMPLLDRLTQLLTGCKSNTCQYFRETVLNEIRKARELYTGAELAAELRRIQQRLDNVECLSADVVINLLLSYRDIQDYESIVKLVETLEKLPTFDPVAHPHIKFHYAFALNRRNLPGDRQKALDIMLPLVNSDEQVASDIYCLVGRIYKDMFLDSHFTDTNSRDQGIHWFRRGFESEPTLHSGINYAVLLLAAGHQFDSSFELRKVGVKLSSLLGKKGSLDRLQSYWDVGFFLGASILACDNTRVIQASEKLFKIKAPIWYLRSLVETILIYKHFTKVSTDPQAPKQELVDFWMDFMVEATNKDKDVTSVRFPVLILEPTKVYQPSYLSINKDAEENTLSIWHVTPDDKKGIHEWNFSAASVRGVSISKFDERSCFLYVVNNSEDFQIYFCTEMHCKRFCDLVNTVTEEAWKGSDENECESEALEYDYEYDEHGEKVVLGKGTFGVVYAGRDLSNQVRLAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSISENGFIKIFMEQVPGGSLSALLRSKWGPLKNNEPTIGFYTKQILDGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKPADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKIHPEIPDSMSSEAKAFILRCFEPDPDSRATANDLLTHEFLTVTSRKKRSKTSSFTALTPGSEYLRSISLPVPVVVEDTSSSSEYGSVSPDNELCTNPFNFRPSSSSKSYSEREVKGHRSLFLSIPVENFEDHSAPPSPEEKDSGFFMLKKDSERRATLHRILTEDREKIVLHLLEALTQGSEETKLKHQHISTLVASLGDFVRMADRKIIASTLSQLKLELDFDSTAISQLQVALFGFQDAVNKVLRNHNIKPHWMFALDNIIRKAVQTAIVILVPELRPHFTLASESDPAEQEDIDDDAVPQGNAALKDMAPALVHHDDTVATSGVSTLSSTVSHESQSAQRSISMELGRMKLETKRLLEELVEKEREYQAILQQVLEDREQEIKLLKCRTGPIDAPVQLVNTRSSLDGDGDLQLLEWLKLHGADADSIERIIAEDYSLDDILHYVTRDDLKTLRLRGGVLCKLWSAITEHRKKPG
InterPro domains: - IPR046872: MAP3K, deoxyribohydrolase domain (domain) [102-137]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [788-800]
- IPR046873: MAP3K, HisK-N-like globin domain (domain) [1033-1164]
- IPR025136: MAP3K, TRAFs-binding domain (domain) [152-532]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [1300-1362]
- IPR043969: MAP3K, PH domain (domain) [545-641]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [674-969]
- IPR017441: Protein kinase, ATP binding site (binding_site) [675-698]
- IPR000719: Protein kinase domain (domain) [669-927]
Interaction partners: - Thioredoxin
- Death domain-associated protein 6
- TNF receptor-associated factor
- Dual specificity mitogen-activated protein kinase kinase 6
- Stress-activated protein kinase JNK
- Dual specificity mitogen-activated protein kinase kinase 7
- Mitogen-activated protein kinase 8
- Serine/threonine-protein phosphatase
- Stress-activated protein kinase JNK
- non-specific serine/threonine protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0045595 (regulation of cell differentiation), GO:0010647 (positive regulation of cell communication), GO:0051962 (positive regulation of nervous system development), GO:0010038 (response to metal ion), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0010001 (glial cell differentiation), GO:0007417 (central nervous system development), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0045685 (regulation of glial cell differentiation), GO:0060429 (epithelium development), GO:1902531 (regulation of intracellular signal transduction), GO:0042063 (gliogenesis), GO:0048713 (regulation of oligodendrocyte differentiation), GO:0014015 (positive regulation of gliogenesis), GO:0045687 (positive regulation of glial cell differentiation), GO:0050767 (regulation of neurogenesis), GO:0048709 (oligodendrocyte differentiation), GO:0048714 (positive regulation of oligodendrocyte differentiation), GO:0014013 (regulation of gliogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)