wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: LD05335p (Zinc transporter 41F, isoform A) (Zinc transporter 41F, isoform B) (Zinc transporter 41F, isoform C) (Zinc transporter 41F, isoform D) (Q8T0G1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MPKYQKLDNTLLPNAHDDDSEGGFPGYFDDNHQSLGIQQDPDTRDDRLSDYQDRYYSVNNNSVNREVVTIGSNVVRVPEEQTWEVPLLGDCGDSARNQSSETEFDMQRECCNHQPGFRANSKSKSAQEAKYKIMLAVALCCVFMIIEFLGGYVAGSLAIMTDAAHLASDCISFVIGLVAIWIGGRPPDERMSFGYKRFEVIGALASILGIWFVTTLLVVVAIERIFSQDFELNADMMMLISGIGIVINIVMMFVLHGSWFVNGNGHGHSHSHSHSHSHSHGNGHEPNDSLSQTRSNSNFLTTIGSQSASTADEEDSIRKEINSNEHKIVITNGKKPTLTGTSNMELAHEDKNLNLRAAMIHVIGDLVQSIGVFLAAVLIKVCPGAKYADPLCTLIFSIIVIMTTLRLFRESLGIIVNAVPQNLNMRTLHLELGSIEGVRSLHHLNVWQQTSQQRVLMVHLVTDSRADGNEVLQAATALVSSPRYNIKHSTIQLEPTTE
InterPro domains: - IPR002524: Cation efflux protein (family) [131-496]
- IPR027470: Cation efflux protein, cytoplasmic domain (domain) [432-495]
- IPR027469: Cation efflux transmembrane domain superfamily (homologous_superfamily) [128-415]
- IPR050681: Cation Diffusion Facilitator/SLC30A (family) [101-496]
Interaction partners: - IP18018p
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- FI23527p1
- Zinc/iron regulated transporter-related protein 42C.2
- P-type Cu
- FI24038p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport), GO:0030001 (metal ion transport), GO:0000041 (transition metal ion transport), GO:0006829 (zinc ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)
Protein: Protein ELYS (G0S2G1)
Organism: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
Function: Required for the assembly of a functional nuclear pore complex (NPC).
Subcellular location: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q8WYP5}.
Sequence: MLDFTHFPEVFPTDGPRPYDQHFVRQTETFRKSLDGVLFIDRVLGALGLPDAAKAYPPRGDAGLRALHQQVCSAKVSAHAKLSVLYYLLLDHDEHRGSRSQLADALAEEVGLPANYQILMRGLWHMDRKEFKFALEHLAHPSLPAEFADEIITVLVRDGHTTGDYSLPLAYYHAVRPVLQTSSALENLFAALARTSVTDALAFSRTYPDHGARQLLFERLVASVLEEHGSGQVAGRSASRAKELVSLPLTGVEEKWLNDYLSTGEGRKSRSAKAVVQMRQVVTGRQKELGAVVGVRAGR
InterPro domains: - IPR025151: ELYS-like domain (domain) [37-263]
Interaction partners: - Nucleoporin NUP152
- Nucleoporin NUP49
- Protein transport protein SEC13
- Nucleoporin NUP133
- Nucleoporin NUP84
- Nucleoporin SEH1
- Nucleoporin NUP170
- Nucleoporin NIC96
- Nucleoporin NUP192
- Nucleoporin NUP145
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0050793 (regulation of developmental process), GO:2000243 (positive regulation of reproductive process), GO:0023051 (regulation of signaling), GO:0051094 (positive regulation of developmental process), GO:2000241 (regulation of reproductive process), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0032101 (regulation of response to external stimulus), GO:0010647 (positive regulation of cell communication), GO:0032103 (positive regulation of response to external stimulus), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0043937 (regulation of sporulation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Irditoxin subunit B (IrTxB) (A0S865)
Organism: Boiga irregularis (Brown tree snake)
Function: This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) nicotinic acetylcholine receptor (nAChR) 100-fold more compared with the mouse receptor. In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos. At sublethal doses geckos were immobilized for up to three days and then recovered. Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen.
Subcellular location: Secreted {ECO:0000269|PubMed:18952712}.
Sequence: MKTLLLAVAVVAFVCLGSADQLGLGRQQIDWGKGQAKGPPYTLCFECNRETCSNCFKDNRCPPYHRTCYTLYRPDGNGEMKWAVKGCAKTCPTAQPGESVQCCNTPKCNDY
InterPro domains: - IPR045860: Snake toxin-like superfamily (homologous_superfamily) [35-111]
- IPR003571: Snake three-finger toxin (family) [42-109]
- IPR018354: Snake toxin, conserved site (conserved_site) [86-106]
- IPR054131: Snake toxin cobra-type (family) [47-109]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0090729 (toxin activity), GO:0030545 (signaling receptor regulator activity), GO:0140678 (molecular function inhibitor activity), GO:0030547 (signaling receptor inhibitor activity), GO:0099602 (neurotransmitter receptor regulator activity), GO:0030548 (acetylcholine receptor regulator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism), GO:0044359 (modulation of molecular function in another organism)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: AT3g04420/T27C4_6 (NAC domain containing protein 48) (Q8W4R4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MENPVGLRFRPTDKEIVVDYLRPKNSDRDTSHVDRVISTVTIRSFDPWELPCQSRIKLKDESWCFFSPKENKYGRGDQQIRKTKSGYWKITGKPKPILRNRQEIGEKKVLMFYMSKELGGSKSDWVMHEYHAFSPTQMMMTYTICKVMFKGDVREISSSSASYGSEIEQSRDSLIPLLVNDSEEEAQIEDAIPIEEWETWLTDDGVDEQVNHIMNMKDDRNNHRPQKPLTGVLIDDSSDDDDDSDLLSPTTNSIENSSTCDSFGSSDQINLVSLTQEVSQALITSIDTPEKIKSPYDDAQGTGAGGQKLGQETREKKRAGFFHRMIQIFVKKIHQCSSISRT
InterPro domains: - IPR003441: NAC domain (domain) [3-150]
- IPR036093: NAC domain superfamily (homologous_superfamily) [2-153]
Interaction partners: - NAC
- At5g18300
- Transcription factor HHO6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:1903338 (regulation of cell wall organization or biogenesis), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:2000652 (regulation of secondary cell wall biogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010087 (phloem or xylem histogenesis), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0010089 (xylem development), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Uncharacterized protein (Q5B9S0)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MKGLQIFVSSVLTLGALAAPTTDMTKRADRGSYTVSGLGQRKQAILNAGGNTLDLAIAMLETEGMTTDYTYGDGKTYDAANFGLFKQNWGMLRVCATRYGLAGQSEADWNNGAILNSNVYADVASRWDCQGYYGVDLWFAGHRNGASGLSNPNTDDINNYKSAVYWIQQQIDSNSVYKTDDTRFWVDVQAI
InterPro domains: - IPR049168: Glycosyl hydrolase family 134 (family) [39-188]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0061783 (peptidoglycan muralytic activity), GO:0016787 (hydrolase activity), GO:0016798 (hydrolase activity, acting on glycosyl bonds), GO:0003796 (lysozyme activity), GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0044237 (cellular metabolic process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0071554 (cell wall organization or biogenesis), GO:0009056 (catabolic process), GO:0006952 (defense response), GO:0044036 (cell wall macromolecule metabolic process), GO:0043207 (response to external biotic stimulus), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0098542 (defense response to other organism), GO:0044248 (cellular catabolic process), GO:0009617 (response to bacterium), GO:0009057 (macromolecule catabolic process), GO:0016998 (cell wall macromolecule catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0042742 (defense response to bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: BBSome interacting protein 1 (J3QMK2)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MAEVKSMFREVLPKQGQLSVEDVTTMVLCKPKLLPLKSLTLEKLEKMQQAAQDTVRQQEMAEKATSK
InterPro domains: - IPR028233: Cilia BBSome complex subunit 10 (family) [1-66]
Interaction partners: - BBSome complex member BBS7
- BBSome complex member BBS1
- Protein PTHB1
- BBSome complex member BBS2
- BBSome complex member BBS5
- Tetratricopeptide repeat protein 8
- BBSome complex member BBS4
- Chaperonin-containing T-complex member BBS12
- BBSome complex assembly protein BBS10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0043473 (pigmentation), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0033059 (cellular pigmentation), GO:0051640 (organelle localization), GO:0070121 (Kupffer's vesicle development), GO:0051649 (establishment of localization in cell), GO:0051875 (pigment granule localization), GO:0051648 (vesicle localization), GO:0006810 (transport), GO:0051656 (establishment of organelle localization), GO:0051904 (pigment granule transport), GO:0051905 (establishment of pigment granule localization), GO:0032400 (melanosome localization), GO:0051650 (establishment of vesicle localization), GO:0032402 (melanosome transport), GO:0032401 (establishment of melanosome localization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)
Protein: Aminoacyl carrier protein 1 (Q89VT6)
Organism: Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
Function: Aminoacyl carrier protein. Can be charged with L-glycine via the formation of a thioester bond between the amino acid and the 4'-phosphopantetheinyl prosthetic group, catalyzed by the bll0957 ligase.
Sequence: MQAFNTDVRNRIIKLVKGILEQNALAADVTPQAKLVDVGLTSMDMVNLMLGVEAEFDFTIPQSEITPENFQSVETLERMVMTQLQPATAA
InterPro domains: - IPR036736: ACP-like superfamily (homologous_superfamily) [6-90]
- IPR009081: Phosphopantetheine binding ACP domain (domain) [6-84]
Interaction partners: - Amino acid--[acyl-carrier-protein] ligase 1
- Blr2316 protein
- Bll2237 protein
- NADH-quinone oxidoreductase subunit C
- Blr2108 protein
- Probable alginate O-acetylase AlgI
- Large ribosomal subunit protein bL21
- Large ribosomal subunit protein bL32
- NADH-quinone oxidoreductase subunit B
- Bll0263 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006790 (sulfur compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044272 (sulfur compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0098533 (ATPase dependent transmembrane transport complex), GO:0043190 (ATP-binding cassette (ABC) transporter complex)
Protein: Cilia- and flagella-associated protein 61 (Flagellar-associated protein 61) (A8IF44)
Organism: Chlamydomonas reinhardtii (Chlamydomonas smithii)
Function: As component of a spoke-associated complex, regulates flagellar dynein activity by mediating regulatory signals between the radial spokes and dynein arms.
Subcellular location: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:17967944}.
Sequence: MSNITARQTLTRDVQSVDALVRQACKAEANATLLLGTGLLNLTAVDDKDTVVGYLSLDDVSCTRLGSGGPGADTWVQQAAASRFKLGSTAFVRVCATAHLSEIEASAALLRTAFLHMPSLQTLLMVAGGELSFTEPGLAAVFSRVGAHKESGAVLYEAGRDAVVPPLAIRPARVEDHDDMLPILQRCEVAFPALAKLPEASRPHEPFALTRVVAGQDERNRVLVAEAEGRLVGFIVMTSDVDTGSLAETFDLHAYDNFLPPEVYEQQYEAARDSVRGQKLAMLRHQRQQEKEAEGEGAGEAGGQGGNGGVSAGMQTDPEQGEDGEGAAEGEGEGAGEGAGEGGAAAPGTGADKADDSEEAEAQLLAAAEPTDEETRAEMLAMFAGQAPPADPTLFAVTMLCMDPAFEAQAIEFLTPAFAAYTDKLYCVVTLPHDSREPALMGTMTRVAPNPGSLFPEVLFMFHRHALIPDFAVRLGEPGDLDAVASLVAGMPNADDIVASFSGAAAAGSAAVALCQGELVGLVTVNPEVDLELLQANFGLSNHVDLGYQPREQHGEIDMYTMNPIFVHRHRTLVAATMRLLGKTALYYALPPGQQPPDMLEVLEQVAPRHRTASDKQLQAEFALYVFTRQAAFKRRRSVNSQIVVVGASECGLAVVERLLLDPELQFNYLTLLAPGGIKVGGMACQFTAGVIARLGLEARVMLLDAEVIGLDRGSKLLDLSDGSQIFYNQLVLAAGLQDQSRYRFAEADPEVAGLLVTELELAADFSMNDAMVMNSILVYGNAMGAYHSLAVLEAKGAGEKTRFVAPPGQQPPLVGVLHALAGEAGVALPSPEPRDLAGLSVVQPVGPELHASATLIDPADPGPREELPVDLVVGCEPPSVSRSLFTCLNDASLVFDGRLVVDGAFRTNDPAIYAGGSLAKLSRRYGGTHLEHYNSRDVGSRLASSLVSFFNAGPDEPQPAATAAAPPPALHRARAVGCSLPGGNYFVYAGCPAALQRPSTAAPEGGYEMKTASERGLTRITLDGEGRVHSLMYLGRVAVNAPRLGSLVGLHANYLNSLAPKYQAGDIKCLLSFITEPWSELLYNESFPELRETLLEVALAELSAGGREVDGGMVEWVTHAQDAVLEFARAHAAELPGYTMPSAART
InterPro domains: - IPR038884: Cilia- and flagella-associated protein 61 (family) [1-1144]
- IPR032151: Cilia- and flagella-associated protein 61, N-terminal domain (domain) [7-258]
- IPR016181: Acyl-CoA N-acyltransferase (homologous_superfamily) [165-244]
- IPR056299: CFAP61, dimerisation domain (domain) [969-1083]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [642-936]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0044782 (cilium organization), GO:0120036 (plasma membrane bounded cell projection organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0031514 (motile cilium)
Protein: Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-) (Q86VU5)
Organism: Homo sapiens (Human)
Function: Putative O-methyltransferase.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Sequence: MTQPVPRLSVPAALALGSAALGAAFATGLFLGRRCPPWRGRREQCLLPPEDSRLWQYLLSRSMREHPALRSLRLLTLEQPQGDSMMTCEQAQLLANLARLIQAKKALDLGTFTGYSALALALALPADGRVVTCEVDAQPPELGRPLWRQAEAEHKIDLRLKPALETLDELLAAGEAGTFDVAVVDADKENCSAYYERCLQLLRPGGILAVLRVLWRGKVLQPPKGDVAAECVRNLNERIRRDVRVYISLLPLGDGLTLAFKI
InterPro domains: - IPR002935: Class I-like SAM-dependent O-methyltransferase (family) [45-262]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [34-262]
- IPR050362: Cation-dependent O-methyltransferase (family) [51-261]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008171 (O-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0008213 (protein alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)