Protein: DNA (cytosine-5)-methyltransferase 3 (EC 2.1.1.37) (DNA methyltransferase 3) (DNA methyltransferase III) (Protein MATERNAL EFFECT EMBRYO ARREST 57) (Q9T0I1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells (By similarity). Required during the endosperm development in seeds.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MKTKAGKQKKRSVDSDDDVSRERRPKRATSGTNFKEKSLRFSEKYETVEAKKEQIVGDDEKEEKGVRFQSFGRVENWTISGYEDGSPVIWISTVIADYDCRKPSKKYKKLYDYFFEKACACVEVCKNLSTNPDTSLKELLAAVVRSMNGRKIFSSGGVIQEFVISQGEFIYNQLAGLDETSKNHETKFVDNRVLVSLRDESRKIHKAFSNVALRIDESKVLTSDQLMDGGEDEDLKYAKLLQEEEHMKSMDRSRNKRSSTTSAPNKFYIKINEDEIAHDYPLPSYYKNTKDETDELVLFNAGYAVDARNLPCRTLHNWALYNSDLMLISLEFLPMKPCADIDVTYLGQIKEWKIDFGEDMIFVLLRTDMAWYRLGKPSEQYAPWFEPILKTVRIGTSILALLKNETRMAKLSYTDVIKRLCGLEENDQAYISSTFFDVERYVIVHGQIILQFLTECPDEYIKRCPFVTGLASKMQDRHHTKWIIKKKRKMLQKGENLNLRRGKAPKVSKMKAMQATTTRLINRIWGEFYSIYSPEDPLEEIGAEEEFEEVEDVEEEDENEEEDTIQKAIEVQKADTLKKIRGSCKEMEIRWEGEILGETCAGEPLYGQALVGGRKMDVGGAVILEVDDQGETPLIYFVEYMFESSDNSKKLHGKLLQRGSETVLGTAANERELFLTNECLTVQLKDIKGTVSFEIRSRPWGHQYKKEHMAADKLDRARAEERKAKDLPIEYYCKSLYSPEKGGFFSLPRSDMGLGSGFCSSCKIRENEEERSKTKLNDSKTRFLSNGIKYSVGDFVYQIPNYLSKDRGKRRPVFKYGRNVGLRAFVVCQILDIVDLKEPKKGNTTSFEVKVRRFYRPDDVSAEEAYASDIQEVYYSEDTYILPPEAIKGKCEVMKKTDMPLCREYPILDHVYFCDRFYDSSNGCLKKLPYNMMLKFSTIKDDTLLREKKTETGSAMLLKPDEVPKGKRLATLDIFAGCGGLSYGLEKAGVSDTKWAIEYEEPAAQAFKQNHPKTTVFVDNCNVILRISWLRLLINDRAIMEKCGDVDDCISTTEAAELATKLDENQKSTLPLPGQVDFISGGPPCQGFSRLNRFSDGSWSKNQCQMILAFLSFADYFRPKYFLLENVKTFVSFNEGHTFHLTVASLLEMGYQVRFGLLEAGAYGISQPRKRAFIWAAAPNEVLPEWPEPMHVFNNPGFKIPLSQGLHYAAVQSTKFGAPFRSITVRDAIGDLPPIESGESKINKEEMRGSMTVLTDHICKKMNELNLIRCKKIPKTPGADWRDLPDEHVNLSNGIVKNIVPNLLNKAKDHNGYKGLYGRLDWHGNLPTCITNLQPMGLVGMCFHPDQDRIISVRECARSQGFPDSYKFSGNIKDKHRQVGNAVPPPLAFALGRKLKEALHLRNI
InterPro domains: - IPR001025: Bromo adjacent homology (BAH) domain (domain) [614-929]
- IPR017198: DNA (cytosine-5)-methyltransferase 1-like (family) [39-1403]
- IPR043151: Bromo adjacent homology (BAH) domain superfamily (homologous_superfamily) [582-942]
- IPR018117: DNA methylase, C-5 cytosine-specific, active site (active_site) [1077-1089]
- IPR050390: DNA Cytosine-5 Methyltransferase (family) [262-1402]
- IPR022702: DNA (cytosine-5)-methyltransferase 1, replication foci domain (domain) [57-422]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [952-1399]
- IPR001525: C-5 cytosine methyltransferase (family) [969-1402]
- IPR031303: DNA methylase, C-5 cytosine-specific, conserved site (conserved_site) [1377-1395]
Interaction partners: - Adenosylhomocysteinase 2
- Adenosylhomocysteinase 1
- E3 ubiquitin-protein ligase ORTHRUS 5
- E3 ubiquitin-protein ligase ORTHRUS 1
- E3 ubiquitin-protein ligase ORTHRUS 3
- E3 ubiquitin-protein ligase ORTHRUS 2
- DNA
- Alpha/beta-Hydrolases superfamily protein
- Transcriptional activator DEMETER
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0019222 (regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0009892 (negative regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0006306 (DNA methylation), GO:0006304 (DNA modification), GO:0032776 (DNA methylation on cytosine), GO:0006305 (DNA alkylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)