Protein: Small ribosomal subunit protein eS7 (P62082)
Organism: Mus musculus (Mouse)
Function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Nucleus, nucleolus. Note=Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. Colocalizes with NEK6 in the centrosome
Sequence: MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
InterPro domains: - IPR047861: Small ribosomal subunit protein eS7, conserved site (conserved_site) [78-91]
- IPR000554: Small ribosomal subunit protein eS7 (family) [1-191]
Interaction partners: - Large ribosomal subunit protein eL21
- Small ribosomal subunit protein uS4
- Large ribosomal subunit protein eL18
- Small ribosomal subunit protein eS28
- Small ribosomal subunit protein eS4
- Small ribosomal subunit protein uS5
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein eS6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0035295 (tube development), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0048863 (stem cell differentiation), GO:0060562 (epithelial tube morphogenesis), GO:0007399 (nervous system development), GO:0021915 (neural tube development), GO:0060606 (tube closure), GO:0002009 (morphogenesis of an epithelium), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0016331 (morphogenesis of embryonic epithelium), GO:0009792 (embryo development ending in birth or egg hatching), GO:0072175 (epithelial tube formation), GO:0014033 (neural crest cell differentiation), GO:0001838 (embryonic epithelial tube formation), GO:0043009 (chordate embryonic development), GO:0001841 (neural tube formation), GO:0001843 (neural tube closure), GO:0014020 (primary neural tube formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0030054 (cell junction), GO:0045202 (synapse)