wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: SUEL-type lectin domain-containing protein (A0A060XUW4)
Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Function: Not known
Sequence: MSCPNQFRVTSRCDGNEKCDVATSGSVCDLCSTAYLTNIFLDVTYGCLESKKVTTCHGVVHLECGDGVVFLQKALYGRIDSQTCSQGRPQSELTNTKCSQEGTLALWSQRCDGKQTCEVNMRVNQISDPCVGTYKYLDVTYICLPAKTSITCEGSTSSLDCGKGVIKVFHANYGRRDGSTCSAGRHELSNQNCLQPKTLDVVKQWCEGKSQCTVGLDPVFGDPCYGTYKYLEVSYTCLGVSPTV
InterPro domains: - IPR000922: D-galactoside/L-rhamnose binding SUEL lectin domain (domain) [54-238]
- IPR043159: D-galactoside/L-rhamnose binding SUEL lectin domain superfamily (homologous_superfamily) [49-240]
Interaction partners: - ZU5 domain-containing protein
- Ig-like domain-containing protein
- Uncharacterized protein
- Netrin receptor UNC5
- Uncharacterized protein
- Netrin receptor UNC5
- ZU5 domain-containing protein
- UPA domain-containing protein
- Death domain-containing protein
- Netrin receptor UNC5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0005515 (protein binding), GO:0070492 (oligosaccharide binding), GO:0048029 (monosaccharide binding), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0042803 (protein homodimerization activity), GO:0048030 (disaccharide binding), GO:0005534 (galactose binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0007155 (cell adhesion), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0098609 (cell-cell adhesion), GO:0043933 (protein-containing complex organization), GO:0034109 (homotypic cell-cell adhesion), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0070206 (protein trimerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0030141 (secretory granule), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0098562 (cytoplasmic side of membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098595 (perivitelline space), GO:0009898 (cytoplasmic side of plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005634 (nucleus), GO:0097708 (intracellular vesicle), GO:0043073 (germ cell nucleus), GO:0001674 (female germ cell nucleus), GO:0042585 (germinal vesicle)
Protein: Dickkopf long isoform (Dickkopf-related protein 3a precursor) (C1K6H6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MFLLGFSLCLAVVHGIVPEIPKTDMDIIANMETNAAQEQTMSDVLKEVEELMEDTQHKLEDAVHQMDNETAKSSLHPQNVSSNLQNYSAIETIAGNQTISIGERINKTTDNSTEETNNLSSIQPRDKENIVDHECVIDEDCEKGKYCLYETHSSKCLPCKQLDASCTKDEECCAGQLCVWGQCTINITKGDAGTICQYQTDCKEDFCCAFHKALLFPVCIAKPIERERCIISANHLMELLSWDMDGEGPQEHCPCAGELQCQHRGRGALCLKSQNSSEEELTDTLYSEIDYIV
InterPro domains: - IPR039863: Dickkopf related protein 1-4 (family) [28-266]
- IPR047300: Dickkopf-related protein 3, second cysteine-rich domain (domain) [186-271]
- IPR006796: Dickkopf, N-terminal cysteine-rich (domain) [134-184]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009888 (tissue development), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0035239 (tube morphogenesis), GO:0048863 (stem cell differentiation), GO:0048864 (stem cell development), GO:0048514 (blood vessel morphogenesis), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0001570 (vasculogenesis), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0060429 (epithelium development), GO:0002040 (sprouting angiogenesis), GO:0014033 (neural crest cell differentiation), GO:0014032 (neural crest cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Anti-sigma-F factor antagonist RsfA (Anti-anti-sigma F factor RsfA) (P9WGE3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Positive, redox-sensitive regulator of sigma-F (SigF) activity. When reduced binds to anti-sigma-F factor RsbW (UsfX) preventing its binding to SigF, thus activating transcription.
Sequence: MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVARIIHACGYGDVLPVHPTTESALSAT
InterPro domains: - IPR036513: STAS domain superfamily (homologous_superfamily) [13-128]
- IPR002645: STAS domain (domain) [17-128]
- IPR003658: Anti-sigma factor antagonist (family) [16-122]
Interaction partners: - Multidomain regulatory protein Rv1364c
- Anti-sigma-F factor RsbW
- Anti-sigma-F factor antagonist RsfB
- Uncharacterized protein Rv1366
- Uncharacterized protein Rv1354c
- Uncharacterized protein Rv2240c
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Membrane-bound acid phosphatase, putative (Q383A6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MMRPLSLVWWAIFVLLAATGANCSYVLELVQVVHRGGITPPPVGTPDREKLCSPDSGSSCAAIANHGVQQLIDMGAYIEKLYKNDDETEGAKAWLGSTYDSAAVYTHSFADPALVQAATALLKGIYAEEQGNITPAVISAPPADDTLLNVNALPSFVLGNEAKAQHFNKTMEEAVDEQFPDSSVIGTMGREVGLSEACSSADNRVWCCHRLQQLATMYSAMKDGGSGAPTVMENVGRLDAVATVRSHTLYGYSTEDELAKARGSLGQPLAQELLLGMRRKMLQKDDVNYNTHKVMQYVHNTPIRTTVGYQPTDLVPVAETFLIDLLRDDTTEVYFVRLRHAVVKTEPAAMPSAADFPFRCVNAAGDSSGVKSKDGFICPFDDFVRFVDSSKGTGAGGAICHLDTSTADNLQCSVVGPPTSPQCERYRRLCPRLACPDGHIYDVVSGMCTSLYADEAILTGGVVASLCIALLFSGVMLGIIMVEMYPVMFKQKMAV
InterPro domains: - IPR029033: Histidine phosphatase superfamily (homologous_superfamily) [26-393]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0003993 (acid phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0016311 (dephosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Developmental and secondary metabolism regulator veA (Velvet complex subunit A) (Q9UW88)
Organism: Emericella nidulans (Aspergillus nidulans)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MQQPKRARACGQGSKSHTDRRPVDPPPVIELNIFESDPHDDSNKTDITFVYNANFFLFATLEPERPIATGKLMTNQGSPVLTGVPVAGVAYLDKPNRAGYFIFPDLSVRNEGSYRFSFHLFEQIKDPKDATEGTQPMPSPVPGKLSSPQEFLEFRLEVISNPFIVYSAKKFPGLTTSTPISRMIAEQGCRVRIRRDVRMRRRGDKRTEDYDYDNERGYNNRRPDQYAGSDAYANAPERPRSTSISTNMDPYSYPSRRPSAVEYGQPIAQPYQRPMASTPAPSSTPIPAPIPMPGPVALPPSTPSPASAHAPAPPSVPLAAPPPLHTPSYQSHLSFGATQTQYPAPQLSHIPQQTTTPTHPYSPRSSISHSRNQSISEYEPSMGYPGSQTRLSAERPSYGQPSQTTSLPPLRHSLEPSVNSRSKTPSNMITSLPPIQSLSELPSTTSQPSSAIGSSPANEPGPRLWETNSMLSKRTYEESFGHDDRPLYNGMRPDSESYPGGMQRRPSYERSSLLDGPDQMAYKRANGRMVSKPATMR
InterPro domains: - IPR021740: Velvet factor (family) [1-211]
- IPR037525: Velvet domain (domain) [1-196]
- IPR038491: Velvet domain superfamily (homologous_superfamily) [1-209]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0043455 (regulation of secondary metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0033240 (positive regulation of amine metabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0042762 (regulation of sulfur metabolic process), GO:0034248 (regulation of amide metabolic process), GO:0051176 (positive regulation of sulfur metabolic process), GO:0034250 (positive regulation of amide metabolic process), GO:0033238 (regulation of amine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) (O44953)
Organism: Caenorhabditis elegans
Function: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Dispensable for SPC enzymatic activity (By similarity).
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P83362}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P83362}.
Sequence: MDGMIAMLPAPLQKLSSHIDFQGQKVAERTYQVILTIAGIIGFLVGFWTQQLSYAMFTVLGASAFTALIILPPWPFLFRKNPIVWHTPAEPQESGDKKKETKKTK
InterPro domains: - IPR009542: Signal peptidase complex subunit 1 (family) [8-103]
Interaction partners: - Signal peptidase complex subunit 2
- Signal peptidase complex subunit 3
- Signal peptidase complex catalytic subunit SEC11
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1
- Protein transport protein Sec61 subunit beta
- Protein transport protein Sec61 subunit gamma
- Mitochondrial inner membrane protease subunit 2
- Peptidase S26 domain-containing protein
- Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
- Signal recognition particle 9 kDa protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: ATP synthase F(1) complex subunit epsilon, mitochondrial (ATPase subunit epsilon) (ATP synthase F1 subunit epsilon) (P56381)
Organism: Homo sapiens (Human)
Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).
Subcellular location: Mitochondrion. Mitochondrion inner membrane.
Sequence: MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAEKTSGSNVKIVKVKKE
InterPro domains: - IPR006721: ATP synthase, F1 complex, epsilon subunit, mitochondrial (family) [1-51]
- IPR036742: ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial (homologous_superfamily) [2-51]
Interaction partners: - ATP synthase F
- ATP synthase peripheral stalk subunit OSCP, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit b, mitochondrial
- ATP synthase F
- ATP synthase F
- ATP synthase peripheral stalk subunit d, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) (Q9HBB8)
Organism: Homo sapiens (Human)
Function: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Subcellular location: Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}.
Sequence: MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTDVPPSPEAGGTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGTTLRPPTSSTPGGPPGAENSTSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATPSGGTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCCGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [68-316]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [65-342]
- IPR020894: Cadherin conserved site (conserved_site) [112-122]
- IPR002126: Cadherin-like (domain) [29-459]
Interaction partners: - Cadherin-related family member 2
- Harmonin
- Cadherin-23
- Unconventional myosin-VIIb
- Cadherin-17
- Ankyrin repeat and SAM domain-containing protein 4B
- Catenin beta-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)
Protein: Epsin-1 (EPS-15-interacting protein 1) (O88339)
Organism: Rattus norvegicus (Rat)
Function: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis (By similarity).
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Colocalizes with clathrin at the Golgi complex. Detected in presynaptic nerve terminals and in synaptosomes. May shuttle to the nucleus when associated with ZBTB16/ZNF145.
Sequence: MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAASDPWGAPAVPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPWGGTPAPAAGEGPTSDPWGSADGGAPVSGPPSSDPWAPAPAFSDPWGGSPAKPSSNGTAVGGFDTEPDEFSDFDRLRTALPTSGSSTGELELLAGEVPARSPGAFDMSGVGGSLAESVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPSGAPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
InterPro domains: - IPR003903: Ubiquitin interacting motif (conserved_site) [183-252]
- IPR013809: ENTH domain (domain) [12-144]
- IPR008942: ENTH/VHS (homologous_superfamily) [1-144]
Interaction partners: - Epidermal growth factor receptor pathway substrate 15
- Clathrin heavy chain 1
- Epidermal growth factor receptor substrate 15-like 1
- Intersectin-1
- AP-2 complex subunit beta
- Clathrin coat assembly protein AP180
- AP-2 complex subunit alpha-2
- Epsin-3
- Clathrin light chain A
- Epsin-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0051049 (regulation of transport), GO:0030100 (regulation of endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098793 (presynapse), GO:0019898 (extrinsic component of membrane), GO:0071944 (cell periphery), GO:0005886 (plasma membrane), GO:0042734 (presynaptic membrane), GO:0019897 (extrinsic component of plasma membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0097060 (synaptic membrane), GO:0099243 (extrinsic component of synaptic membrane), GO:0098888 (extrinsic component of presynaptic membrane), GO:0031594 (neuromuscular junction)