Protein: E3 ubiquitin ligase TRAF3IP2 (O43734)
Organism: Homo sapiens (Human)
Function: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways
Sequence: MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSLGGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNRAGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL
InterPro domains: - IPR013568: SEFIR domain (domain) [409-552]
- IPR053047: E3 ubiquitin ligase TRAF3IP2 (family) [1-574]
Interaction partners: - TNF receptor-associated factor 3
- Interleukin-17 receptor A
- TNF receptor-associated factor 6
- NF-kappa-B essential modulator
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Interleukin-17 receptor C
- Interleukin-17A
- TNF receptor-associated factor 5
- Interleukin-17 receptor B
- Heat shock protein HSP 90-alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0007163 (establishment or maintenance of cell polarity), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0001776 (leukocyte homeostasis), GO:0032941 (secretion by tissue), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0002440 (production of molecular mediator of immune response), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0002520 (immune system development), GO:0009893 (positive regulation of metabolic process), GO:0002252 (immune effector process), GO:0006950 (response to stress), GO:0002262 (myeloid cell homeostasis), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0002260 (lymphocyte homeostasis), GO:0002250 (adaptive immune response), GO:0012501 (programmed cell death), GO:0043487 (regulation of RNA stability), GO:0030010 (establishment of cell polarity), GO:0048468 (cell development), GO:0009410 (response to xenobiotic stimulus), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0023019 (signal transduction involved in regulation of gene expression), GO:0046649 (lymphocyte activation), GO:0045184 (establishment of protein localization), GO:0009894 (regulation of catabolic process), GO:0050878 (regulation of body fluid levels), GO:0046907 (intracellular transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0002443 (leukocyte mediated immunity), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002269 (leukocyte activation involved in inflammatory response), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0002377 (immunoglobulin production), GO:0048872 (homeostasis of number of cells), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0006959 (humoral immune response), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0002274 (myeloid leukocyte activation), GO:0080090 (regulation of primary metabolic process), GO:0048534 (hematopoietic or lymphoid organ development), GO:0071705 (nitrogen compound transport), GO:0048535 (lymph node development), GO:0043488 (regulation of mRNA stability), GO:0031330 (negative regulation of cellular catabolic process), GO:0071702 (organic substance transport), GO:0001782 (B cell homeostasis), GO:0051169 (nuclear transport), GO:0043588 (skin development), GO:0048536 (spleen development), GO:0010468 (regulation of gene expression), GO:0030098 (lymphocyte differentiation), GO:0002449 (lymphocyte mediated immunity), GO:0006886 (intracellular protein transport), GO:0043412 (macromolecule modification), GO:0043489 (RNA stabilization), GO:0015031 (protein transport), GO:0072359 (circulatory system development), GO:0002444 (myeloid leukocyte mediated immunity), GO:0051252 (regulation of RNA metabolic process), GO:0019221 (cytokine-mediated signaling pathway), GO:0010467 (gene expression), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0042113 (B cell activation), GO:0007507 (heart development), GO:0072001 (renal system development), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0002381 (immunoglobulin production involved in immunoglobulin-mediated immune response), GO:0002521 (leukocyte differentiation), GO:0071310 (cellular response to organic substance), GO:0072594 (establishment of protein localization to organelle), GO:0046903 (secretion), GO:0010628 (positive regulation of gene expression), GO:0036230 (granulocyte activation), GO:0036211 (protein modification process), GO:0006954 (inflammatory response), GO:0007589 (body fluid secretion), GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0006915 (apoptotic process), GO:0042110 (T cell activation), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0001822 (kidney development), GO:0006606 (protein import into nucleus), GO:1902373 (negative regulation of mRNA catabolic process), GO:0061013 (regulation of mRNA catabolic process), GO:0042119 (neutrophil activation), GO:0071345 (cellular response to cytokine stimulus), GO:0048255 (mRNA stabilization), GO:1903131 (mononuclear cell differentiation), GO:1903311 (regulation of mRNA metabolic process), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0097396 (response to interleukin-17), GO:0030217 (T cell differentiation), GO:1903312 (negative regulation of mRNA metabolic process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0033209 (tumor necrosis factor-mediated signaling pathway), GO:1902369 (negative regulation of RNA catabolic process), GO:0019724 (B cell mediated immunity), GO:0034612 (response to tumor necrosis factor), GO:0030183 (B cell differentiation), GO:0071887 (leukocyte apoptotic process), GO:0010608 (post-transcriptional regulation of gene expression), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0016064 (immunoglobulin mediated immune response), GO:0070227 (lymphocyte apoptotic process), GO:0032446 (protein modification by small protein conjugation), GO:0071356 (cellular response to tumor necrosis factor), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)