Protein: TNF receptor-associated factor (EC 2.3.2.27) (Q6DEG0)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, ECO:0000256|PIRNR:PIRNR015614}.
Sequence: MSAGRNVEQQIPLQQRPPSLAMPSMAQRPRPEPGFSPLHGGFRDHFVTTPEPKYCCETCRLVLCNPRQTECGHRFCESCINELLSKPNPVCPADLLPLFEDKIFRDVCCNREIMALKVYCRSEKNGCKEQMCLQQVMEHLVICPYFEVPCPLGKCKEKMMRKDMPEHLSRKCKHREVTCEFCSLKMALTELQKHKETVCPAFPVACPNHCSFSSILRSELSSHQHDCPKAQVTCSFIRYGCSYKGLNQEMREHESSFASEHLRMMAVRNTTLEAKVEDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNRQLEQKLVSMQMLMSSHSEKLLEVEMELRELRPLRAMREEVETLRGSVESMRSMVSSLDSSCVNSASGSHTLASLEQQLTRHDDLMSVHDVRLAEMDLKLQVLETASFNGTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVVMRGEYDALLQWPFKQKVTLMLMDQGPARKHLGDAFKPDPSSSSFRRPTGEMNIASGCPLFVAQTVLENGTYIKDDTIFIKVTVDTSDLPDP
InterPro domains: - IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [71-80]
- IPR037304: TNF receptor-associated factor 3, MATH domain (domain) [383-568]
- IPR001293: Zinc finger, TRAF-type (domain) [139-251]
- IPR002083: MATH/TRAF domain (domain) [420-565]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [42-260]
- IPR008974: TRAF-like (homologous_superfamily) [382-573]
- IPR027128: TNF receptor-associated factor 3, C3HC3D-type RING zinc finger (domain) [54-95]
- IPR012227: TNF receptor-associated factor TRAF, metazoa (family) [18-573]
- IPR049440: TNF receptor-associated factor 3/5, RING domain (domain) [56-93]
- IPR049342: TRAF1-6, MATH domain (domain) [443-562]
- IPR001841: Zinc finger, RING-type (domain) [56-94]
Interaction partners: - Serine/threonine-protein kinase TBK1
- TRAF family member-associated NFKB activator.
- Mitochondrial antiviral-signaling protein
- Tumor necrosis factor receptor type 1-associated DEATH domain protein
- Inhibitor of nuclear factor kappa B kinase subunit epsilon
- TIR domain-containing adapter molecule 1
- Mitogen-activated protein kinase kinase kinase 14
- Receptor-interacting serine-threonine kinase 2.
- OTU domain-containing protein 5-A
- Interferon regulatory factor 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009617 (response to bacterium), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009615 (response to virus), GO:0046649 (lymphocyte activation), GO:0098542 (defense response to other organism), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0002521 (leukocyte differentiation), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051607 (defense response to virus), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0019221 (cytokine-mediated signaling pathway), GO:0010468 (regulation of gene expression), GO:0042113 (B cell activation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030183 (B cell differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0071345 (cellular response to cytokine stimulus), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)