Protein: Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36) (Q8WTV0)
Organism: Homo sapiens (Human)
Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
Subcellular location: Cell membrane {ECO:0000269|PubMed:26965621}; Multi-pass membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q61009}; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Sequence: MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
InterPro domains: - IPR002159: CD36 family (family) [13-467]
- IPR005428: CD36/scavenger receptor class B member 1 (family) [68-459]
Interaction partners: - Apolipoprotein A-I
- Apolipoprotein B-100
- Toll-like receptor 4
- Toll-like receptor 2
- CD81 antigen
- Leukocyte surface antigen CD47
- Thrombospondin-1
- Toll-like receptor 6
- Tyrosine-protein kinase Lyn
- Apolipoprotein E
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0072341 (modified amino acid binding), GO:0008289 (lipid binding), GO:0005319 (lipid transporter activity), GO:0050997 (quaternary ammonium group binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0031210 (phosphatidylcholine binding), GO:0005548 (phospholipid transporter activity), GO:0043169 (cation binding), GO:0001786 (phosphatidylserine binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0007586 (digestion), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0097006 (regulation of plasma lipoprotein particle levels), GO:0034381 (plasma lipoprotein particle clearance), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0071827 (plasma lipoprotein particle organization), GO:0044238 (primary metabolic process), GO:1901615 (organic hydroxy compound metabolic process), GO:0055088 (lipid homeostasis), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0090132 (epithelium migration), GO:0034369 (plasma lipoprotein particle remodeling), GO:0006066 (alcohol metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0010876 (lipid localization), GO:1901360 (organic cyclic compound metabolic process), GO:0006629 (lipid metabolic process), GO:0006810 (transport), GO:0050673 (epithelial cell proliferation), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0050877 (nervous system process), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0016477 (cell migration), GO:0010631 (epithelial cell migration), GO:0008202 (steroid metabolic process), GO:0071702 (organic substance transport), GO:0016042 (lipid catabolic process), GO:0001667 (ameboidal-type cell migration), GO:0006869 (lipid transport), GO:1901616 (organic hydroxy compound catabolic process), GO:0046164 (alcohol catabolic process), GO:0055092 (sterol homeostasis), GO:0031326 (regulation of cellular biosynthetic process), GO:1901361 (organic cyclic compound catabolic process), GO:0050994 (regulation of lipid catabolic process), GO:0043933 (protein-containing complex organization), GO:0019216 (regulation of lipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0001935 (endothelial cell proliferation), GO:0015914 (phospholipid transport), GO:0015850 (organic hydroxy compound transport), GO:0046864 (isoprenoid transport), GO:0015748 (organophosphate ester transport), GO:0006707 (cholesterol catabolic process), GO:0006706 (steroid catabolic process), GO:0034367 (protein-containing complex remodeling), GO:0071825 (protein-lipid complex subunit organization), GO:0015918 (sterol transport), GO:0043542 (endothelial cell migration), GO:0008203 (cholesterol metabolic process), GO:0042632 (cholesterol homeostasis), GO:0030301 (cholesterol transport), GO:0034368 (protein-lipid complex remodeling), GO:0046865 (terpenoid transport), GO:0033344 (cholesterol efflux)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005773 (vacuole), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)