Protein: Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (P47876)
Organism: Mus musculus (Mouse)
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).
Subcellular location: Secreted {ECO:0000250|UniProtKB:P08833}.
Sequence: MPEFLTVVSWPFLILLSFQIGVAAGAPQPWHCAPCTAERLGLCPPVPASCPEISRPAGCGCCPTCALPMGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVPEPAAPATSTLFSSQHEEAKAAVVSADELSESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREIADLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVHN
InterPro domains: - IPR017891: Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site (conserved_site) [58-73]
- IPR036857: Thyroglobulin type-1 superfamily (homologous_superfamily) [153-269]
- IPR000867: Insulin-like growth factor-binding protein, IGFBP (domain) [28-109]
- IPR022321: Insulin-like growth factor-binding protein family 1-6, chordata (family) [70-244]
- IPR022322: Insulin-like growth factor-binding protein 1 (family) [43-260]
- IPR000716: Thyroglobulin type-1 (domain) [186-268]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [30-110]
Interaction partners: - Insulin-like growth factor 1
- Insulin-like growth factor 2
- Insulin-1
- Insulin-2
- Insulin-like growth factor-binding protein 6
- Secreted phosphoprotein 24
- Insulin-like growth factor 1 receptor
- Cation-independent mannose-6-phosphate receptor
- Pappalysin-1
- Protein delta homolog 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0005520 (insulin-like growth factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0071704 (organic substance metabolic process), GO:0045927 (positive regulation of growth), GO:0044281 (small molecule metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007568 (aging), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0035556 (intracellular signal transduction), GO:0001558 (regulation of cell growth), GO:0071495 (cellular response to endogenous stimulus), GO:0005996 (monosaccharide metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0005975 (carbohydrate metabolic process), GO:0030307 (positive regulation of cell growth), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0042246 (tissue regeneration), GO:0051128 (regulation of cellular component organization), GO:0010259 (multicellular organism aging), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0019318 (hexose metabolic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0048017 (inositol lipid-mediated signaling), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0006006 (glucose metabolic process), GO:0048015 (phosphatidylinositol-mediated signaling), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:1901653 (cellular response to peptide), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0008286 (insulin receptor signaling pathway), GO:0032869 (cellular response to insulin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)