Protein: Actin-depolymerizing factor 2, isoform c (Uncoordinated protein 60) (Q07749)
Organism: Caenorhabditis elegans
Function: Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle.
Sequence: MASGVKVDPSCKNAYDLLHNKHQHSYIIFKIDKNDTAIVVEKVGEKNAPYAEFVEEMKKLVEDGKECRYAAVDVEVTVQRQGAEGTSTLNKVIFVQYCPDNAPVRRRMLYASSVRALKASLGLESLFQVQASEMSDLDEKSVKSDLMSNQRI
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [1-152]
- IPR017904: ADF/Cofilin (family) [2-146]
- IPR002108: Actin-depolymerising factor homology domain (domain) [4-147]
Interaction partners: - Actin
- Actin-interacting protein 1
- Profilin-1
- Profilin-2
- Profilin-3
- Ras-like GTP-binding protein rhoA
- Gelsolin-like protein 1
- Anaphase-promoting complex subunit 4-like WD40 domain-containing protein
- Twinfilin
- Actin-related protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0030029 (actin filament-based process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051129 (negative regulation of cellular component organization), GO:0035148 (tube formation), GO:0048731 (system development), GO:0051130 (positive regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0030036 (actin cytoskeleton organization), GO:0044087 (regulation of cellular component biogenesis), GO:0035295 (tube development), GO:0048598 (embryonic morphogenesis), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0035239 (tube morphogenesis), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:0055123 (digestive system development), GO:0043244 (regulation of protein-containing complex disassembly), GO:0032956 (regulation of actin cytoskeleton organization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0048546 (digestive tract morphogenesis), GO:1902903 (regulation of supramolecular fiber organization), GO:0010639 (negative regulation of organelle organization), GO:0007015 (actin filament organization), GO:0032231 (regulation of actin filament bundle assembly), GO:0033043 (regulation of organelle organization), GO:0043243 (positive regulation of protein-containing complex disassembly), GO:0043933 (protein-containing complex organization), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0022411 (cellular component disassembly), GO:0097435 (supramolecular fiber organization), GO:0009792 (embryo development ending in birth or egg hatching), GO:0032272 (negative regulation of protein polymerization), GO:0051493 (regulation of cytoskeleton organization), GO:0051494 (negative regulation of cytoskeleton organization), GO:1901879 (regulation of protein depolymerization), GO:0032271 (regulation of protein polymerization), GO:0030837 (negative regulation of actin filament polymerization), GO:0030832 (regulation of actin filament length), GO:0008154 (actin polymerization or depolymerization), GO:0007010 (cytoskeleton organization), GO:0032984 (protein-containing complex disassembly), GO:0110053 (regulation of actin filament organization), GO:0051495 (positive regulation of cytoskeleton organization), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0051261 (protein depolymerization), GO:0030833 (regulation of actin filament polymerization), GO:0030042 (actin filament depolymerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043292 (contractile fiber), GO:0043228 (non-membrane-bounded organelle), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber)