Protein: Glutamine synthetase (EC 6.3.1.2) (A0A2R8YDT1)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
Sequence: MVETPRLRRVTRGSSPSRKSTKKATNENYEDNEKSDSSGSRSSCFGFVAYSVNSGERSRVKIKTLTHQPACSDTPRAGRCLSPSPSPSPRKLRCLDQLESEKEERRERHSKKRRVKEGNPNDTLDFLWLGTPSTMTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
InterPro domains: - IPR014746: Glutamine synthetase/guanido kinase, catalytic domain (homologous_superfamily) [244-496]
- IPR027303: Glutamine synthetase, glycine-rich site (conserved_site) [375-391]
- IPR027302: Glutamine synthetase, N-terminal conserved site (conserved_site) [196-213]
- IPR036651: Glutamine synthetase, N-terminal domain superfamily (homologous_superfamily) [135-244]
- IPR050292: Glutamine Synthetase (family) [149-495]
- IPR008147: Glutamine synthetase, N-terminal domain (domain) [158-240]
- IPR008146: Glutamine synthetase, catalytic domain (domain) [244-507]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016874 (ligase activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016746 (acyltransferase activity), GO:0016879 (ligase activity, forming carbon-nitrogen bonds), GO:0019707 (protein-cysteine S-acyltransferase activity), GO:0016747 (acyltransferase activity, transferring groups other than amino-acyl groups), GO:0019706 (protein-cysteine S-palmitoyltransferase activity), GO:0016880 (acid-ammonia (or amide) ligase activity), GO:0016417 (S-acyltransferase activity), GO:0016409 (palmitoyltransferase activity), GO:0016211 (ammonia ligase activity), GO:0004356 (glutamate-ammonia ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0008283 (cell population proliferation), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0050793 (regulation of developmental process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:0040012 (regulation of locomotion), GO:0044085 (cellular component biogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:2000145 (regulation of cell motility), GO:0044282 (small molecule catabolic process), GO:0044248 (cellular catabolic process), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010632 (regulation of epithelial cell migration), GO:2000026 (regulation of multicellular organismal development), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0043603 (amide metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006536 (glutamate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0008652 (amino acid biosynthetic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:1901342 (regulation of vasculature development), GO:0032880 (regulation of protein localization), GO:0030334 (regulation of cell migration), GO:1901605 (alpha-amino acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0036211 (protein modification process), GO:0016054 (organic acid catabolic process), GO:0043412 (macromolecule modification), GO:0010594 (regulation of endothelial cell migration), GO:0016053 (organic acid biosynthetic process), GO:0009063 (amino acid catabolic process), GO:0045765 (regulation of angiogenesis), GO:0034645 (cellular macromolecule biosynthetic process), GO:0042157 (lipoprotein metabolic process), GO:0009065 (glutamine family amino acid catabolic process), GO:1903670 (regulation of sprouting angiogenesis), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009064 (glutamine family amino acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0043543 (protein acylation), GO:0042158 (lipoprotein biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0042254 (ribosome biogenesis), GO:0006538 (glutamate catabolic process), GO:0006497 (protein lipidation), GO:1901606 (alpha-amino acid catabolic process), GO:1900180 (regulation of protein localization to nucleus), GO:0043648 (dicarboxylic acid metabolic process), GO:0006541 (glutamine metabolic process), GO:0009084 (glutamine family amino acid biosynthetic process), GO:0043649 (dicarboxylic acid catabolic process), GO:0018345 (protein palmitoylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle), GO:0005634 (nucleus)