Protein: HTH-type transcriptional activator AmpR (P24734)
Organism: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Function: This protein is a positive regulator of gene expression of beta-lactamase (AmpC).
Subcellular location: Cytoplasm {ECO:0000305}. Membrane {ECO:0000303|PubMed:25182487}.
Sequence: MVRPHLPLNALRAFEASARHLSFTRAAIELCVTQAAVSHQVKSLEERLGVALFKRLPRGLMLTHEGESLLPVLCDSFDRIAGLLERFEGGHYRDVLTVGAVGTFTVGWLLPRLEDFQARHPFIDLRLSTHNNRVDIAAEGLDYAIRFGGGAWHGTEALALFEAPLTVLCCPEVAAQLHSPADLLQHTLLRSYRADEWPLWFQAAGLPAHAPLTRSIVFDTSLAMLEAARQGVGVALAPAAMFARQLASESIRRPFATEVSTGSYWLTRLQSRGETSAMLAFRGWLLEMAAVEARGR
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [2-86]
- IPR037420: HTH-type transcriptional activator AmpR, PBP2 (domain) [95-285]
- IPR000847: LysR, HTH, N-terminal domain (domain) [6-67]
- IPR005119: LysR, substrate-binding (domain) [91-289]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [2-87]
Interaction partners: - Beta-lactamase
- Beta-hexosaminidase
- 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
- AmpG
- N-acetylmuramoyl-L-alanine amidase
- N-acetylmuramoyl-L-alanine amidase
- Porin D
- NalD
- Multidrug resistance operon repressor
- Transcriptional regulator MexT
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0062012 (regulation of small molecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0033240 (positive regulation of amine metabolic process), GO:0010565 (regulation of cellular ketone metabolic process), GO:0045764 (positive regulation of amino acid metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0033238 (regulation of amine metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0006521 (regulation of cellular amino acid metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0032993 (protein-DNA complex)