Protein: Phosducin-like protein 1 (Q71A39)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Required for normal chemotaxis in response to cAMP and folate. Required for the heterodimerization of the G protein beta and gamma subunits gpbA and gpgA, which is itself thought to be necessary for prenylation of the gamma subunit gpgA and its association with plasma membranes
Subcellular location: Cytoplasm
Sequence: MEQNILNSILDKFGDGDQERSDIRHNDSGDENDNHSDHEGNHGNNECCEGNEDGDKEYEVDVEDMTDEQYAQFIQEQQEPKIKSGGNTGVKGVLSDYAEHREKQKQKYLQKKYETQKMLEKMCFTTRDQPPPTEEENQLDSDDDDLERIRKARMEQWKSKQQITSDVKKPEKKVFGYFKQIDSSQYIHEIDNEPPNVFVIIHLFQNYIPECVLLNQQLGQLAVKYRYIKFLKILSKEAKENYHDEALPSLLVYIGGKLLVSFVPLTEELGRNFDQEDLELLLSSYDIIPNPMKAKNSNWETSLSRKRPESDDDNDD
InterPro domains: - IPR023196: Phosducin, N-terminal domain superfamily (homologous_superfamily) [83-168]
- IPR051498: Phosducin-like chaperone and apoptosis regulator (family) [101-315]
- IPR001200: Phosducin (family) [78-286]
- IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [85-290]
- IPR024253: Phosducin, thioredoxin-like domain (domain) [95-290]
Interaction partners: - T-complex protein 1 subunit beta
- T-complex protein 1 subunit zeta
- T-complex protein 1 subunit theta
- Synembryn-A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0051015 (actin filament binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0042330 (taxis), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0065009 (regulation of molecular function), GO:0009991 (response to extracellular stimulus), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0051098 (regulation of binding), GO:0006935 (chemotaxis), GO:0010033 (response to organic substance), GO:0010243 (response to organonitrogen compound), GO:0051246 (regulation of protein metabolic process), GO:0031667 (response to nutrient levels), GO:0008277 (regulation of G protein-coupled receptor signaling pathway), GO:0043327 (chemotaxis to cAMP), GO:0014070 (response to organic cyclic compound), GO:0043393 (regulation of protein binding), GO:0033273 (response to vitamin), GO:0051593 (response to folic acid), GO:0031399 (regulation of protein modification process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)