Protein: Glycine betaine/proline betaine transport system ATP-binding protein ProV (P14175)
Organism: Escherichia coli (strain K12)
Function: Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for energy coupling to the transport system (Probable).
Subcellular location: Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}.
Sequence: MAIKLEIKNLYKIFGEHPQRAFKYIEQGLSKEQILEKTGLSLGVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEPTRGQVLIDGVDIAKISDAELREVRRKKIAMVFQSFALMPHMTVLDNTAFGMELAGINAEERREKALDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVRTFFRGVDISQVFSAKDIARRTPNGLIRKTPGFGPRSALKLLQDEDREYGYVIERGNKFVGAVSIDSLKTALTQQQGLDAALIDAPLAVDAQTPLSELLSHVGQAPCAVPVVDEDQQYVGIISKGMLLRALDREGVNNG
InterPro domains: - IPR017871: ABC transporter-like, conserved site (conserved_site) [165-179]
- IPR003593: AAA+ ATPase domain (domain) [53-242]
- IPR046342: CBS domain superfamily (homologous_superfamily) [276-395]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [33-289]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [29-265]
- IPR000644: CBS domain (domain) [343-400]
- IPR051921: ABC transporter osmolyte uptake ATP-binding protein (family) [1-398]
- IPR005892: Glycine betaine/proline betaine transport system ATP-binding protein ProV-like (family) [36-394]
Interaction partners: - Glycine betaine/proline betaine-binding periplasmic protein
- Glycine betaine/proline betaine transport system permease protein ProW
- Glutathione/L-cysteine transport system ATP-binding/permease protein CydD
- Molybdenum transport system permease protein ModB
- Glycine betaine uptake system permease protein YehY
- Glycine betaine uptake system permease protein YehW
- Multidrug resistance-like ATP-binding protein MdlB
- Probable multidrug ABC transporter permease YbhS
- Potassium-transporting ATPase potassium-binding subunit
- sn-glycerol-3-phosphate transport system permease protein UgpA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005315 (inorganic phosphate transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0006974 (cellular response to DNA damage stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0098533 (ATPase dependent transmembrane transport complex), GO:0043190 (ATP-binding cassette (ABC) transporter complex)