Protein: Pro-neuregulin-4, membrane-bound isoform (Pro-NRG4) [Cleaved into: Neuregulin-4 (NRG-4)] (Q9WTX4)
Organism: Mus musculus (Mouse)
Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
Subcellular location: [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted {ECO:0000250}.
Sequence: MPTDHEQPCGPRHRSFCLNGGICYVIPTIPSPFCRCIENYTGARCEEVFLPSSSIPSESNLSAAFVVLAVLLTLTIAALCFLCRKGHLQRASSVQCEISLVETNNTRTRHSHREH
InterPro domains: - IPR000742: EGF-like domain (domain) [5-46]
Interaction partners: - Receptor tyrosine-protein kinase erbB-4
- Pro-neuregulin-2, membrane-bound isoform
- Pro-neuregulin-1, membrane-bound isoform
- Pro-neuregulin-3, membrane-bound isoform
- Receptor tyrosine-protein kinase erbB-3
- Epidermal growth factor receptor
- Receptor tyrosine-protein kinase erbB-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0019207 (kinase regulator activity), GO:0008047 (enzyme activator activity), GO:0030546 (signaling receptor activator activity), GO:0070851 (growth factor receptor binding), GO:0030297 (transmembrane receptor protein tyrosine kinase activator activity), GO:0048018 (receptor ligand activity), GO:0019209 (kinase activator activity), GO:0019887 (protein kinase regulator activity), GO:0005154 (epidermal growth factor receptor binding), GO:0030295 (protein kinase activator activity), GO:0030296 (protein tyrosine kinase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0008283 (cell population proliferation), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0061377 (mammary gland lobule development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0031325 (positive regulation of cellular metabolic process), GO:0048731 (system development), GO:0050673 (epithelial cell proliferation), GO:0048513 (animal organ development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0060749 (mammary gland alveolus development), GO:0080090 (regulation of primary metabolic process), GO:0008284 (positive regulation of cell population proliferation), GO:0035239 (tube morphogenesis), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0048514 (blood vessel morphogenesis), GO:0051246 (regulation of protein metabolic process), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0048732 (gland development), GO:0051247 (positive regulation of protein metabolic process), GO:0022612 (gland morphogenesis), GO:0061008 (hepaticobiliary system development), GO:0051174 (regulation of phosphorus metabolic process), GO:0030879 (mammary gland development), GO:0019220 (regulation of phosphate metabolic process), GO:0001889 (liver development), GO:0031399 (regulation of protein modification process), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0045937 (positive regulation of phosphate metabolic process), GO:0072576 (liver morphogenesis), GO:0031401 (positive regulation of protein modification process), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0042327 (positive regulation of phosphorylation), GO:0038127 (ERBB signaling pathway), GO:0001934 (positive regulation of protein phosphorylation), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0007173 (epidermal growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)