Protein: GPI-anchored hemophore PGA10 (Q59UP6)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Involved in biofilm formation
Subcellular location: Secreted, cell wall. Cell membrane; Lipid- anchor, GPI-anchor. Note=Found anchored in the cell membrane as well as a covalently-linked GPI-modified cell wall protein (GPI-CWP)
Sequence: MMSFSLLSIVSIALAATVSATSDGTNAYTAYPSVAKTASINGFADKIYDQLPECAKECVKQSTSNTPCPYWDTGCLCVMPQFGGAIGDCVAKNCKGKEVDSVESLATSICSSAGVGEPYWMIPSSVSDALAKAANAASATTSVETATKSAAAELATTSDTTIVASTSHESKVAETSVAQQTASTEKSSAAETSRAKETSKAEESSKAEETSVAQSSSSANVASVSAETANAGNMPVIAIGGVIAAFAALI
InterPro domains: - IPR008427: Extracellular membrane protein, CFEM domain (domain) [26-137]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0046906 (tetrapyrrole binding), GO:0020037 (heme binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0048878 (chemical homeostasis), GO:0051641 (cellular localization), GO:0019725 (cellular homeostasis), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0051234 (establishment of localization), GO:0033036 (macromolecule localization), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0098630 (aggregation of unicellular organisms), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0098771 (inorganic ion homeostasis), GO:0090609 (single-species submerged biofilm formation), GO:0031589 (cell-substrate adhesion), GO:0045184 (establishment of protein localization), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:0055080 (monoatomic cation homeostasis), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:0071702 (organic substance transport), GO:0042710 (biofilm formation), GO:0016192 (vesicle-mediated transport), GO:0043708 (cell adhesion involved in biofilm formation), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0008104 (protein localization), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0055072 (iron ion homeostasis), GO:0033365 (protein localization to organelle), GO:0006897 (endocytosis), GO:0090605 (submerged biofilm formation), GO:0006879 (intracellular iron ion homeostasis), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0006898 (receptor-mediated endocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009277 (fungal-type cell wall), GO:0030445 (yeast-form cell wall)