Protein: Immunoglobulin lambda constant 7 (Ig lambda-7 chain C region) (A0M8Q6)
Organism: Homo sapiens (Human)
Function: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Subcellular location: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
Sequence: GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFNPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [3-99]
- IPR050160: Major Histocompatibility Complex/Immunoglobulin (family) [4-101]
- IPR007110: Immunoglobulin-like domain (domain) [7-101]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [2-106]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [85-91]
- IPR003597: Immunoglobulin C1-set (domain) [9-97]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0009893 (positive regulation of metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0001819 (positive regulation of cytokine production), GO:0002274 (myeloid leukocyte activation), GO:0001817 (regulation of cytokine production), GO:1903555 (regulation of tumor necrosis factor superfamily cytokine production), GO:0032732 (positive regulation of interleukin-1 production), GO:1903557 (positive regulation of tumor necrosis factor superfamily cytokine production), GO:0010628 (positive regulation of gene expression), GO:0032652 (regulation of interleukin-1 production), GO:0010468 (regulation of gene expression), GO:0032680 (regulation of tumor necrosis factor production), GO:0032731 (positive regulation of interleukin-1 beta production), GO:0032651 (regulation of interleukin-1 beta production), GO:0032760 (positive regulation of tumor necrosis factor production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0072562 (blood microparticle), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)