Protein: Popeye domain-containing protein 1 (Popeye protein 1) (Blood vessel epicardial substance) (BVES) (hBVES) (Q5PQZ7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. May be involved in epithelial movement during corneal sheet formation and regeneration. May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity. May also be involved in striated muscle regeneration and in the regulation of cell spreading (By similarity).
Subcellular location: Lateral cell membrane {ECO:0000250|UniProtKB:Q8NE79}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8NE79}. Membrane {ECO:0000269|PubMed:26642364}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:26642364}. Membrane, caveola {ECO:0000250|UniProtKB:Q9ES83}. Note=Detected at points of cell-cell contact in confluent epithelial sheets. Colocalizes with components of the adherens and tight junctions (By similarity). {ECO:0000250|UniProtKB:Q9ES83}.
Sequence: MSNTTSALPSSVPAVSLDPNATLCQDWEQSHHLLFHLANLSLGLGFLIPTTLALHMIFLRLLLMTGCSLFIAWATLYRCTLDVMVWNVVFLLVNFMHFFFLLYKRRPIKIDRELKSVYKRMFEPLHVREALFQRLTGQFCTIQTLKKGQVYAAEDKTSVDERLSILLKGKMKVSYRGHFLHNIYTNAFIDSPEFRSTQMNRGERFQVTIAAEENCKLLCWSRERLTYFLESESFLNEVFRYLIGKDITNKLYSLNDPTLSDKAVKKMDRQPSLCSQLSMMQMRNSMASTSDTDDVLNQILRGGSTGSSLQKNPLTKTSTTMKPIEEGLEDDVFESESPTTSQNVSKTTKKDI
InterPro domains: - IPR055272: POPDC1-3 domain (domain) [31-256]
- IPR006916: POPDC1-3 (family) [14-336]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [139-245]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [118-251]
Interaction partners: - Tight junction protein 1a
- Potassium channel subfamily K member 2 isoform X1
- Potassium channel subfamily K member 2b
- Vesicle-associated membrane protein 3
- Caveolin
- NDRG family member 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0007389 (pattern specification process), GO:0035295 (tube development), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0009790 (embryo development), GO:0035239 (tube morphogenesis), GO:0009855 (determination of bilateral symmetry), GO:0060562 (epithelial tube morphogenesis), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0042692 (muscle cell differentiation), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0048562 (embryonic organ morphogenesis), GO:0072359 (circulatory system development), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0035051 (cardiocyte differentiation), GO:0007507 (heart development), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0001947 (heart looping)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)