Protein: Syndecan-1 (SYND1) (CD antigen CD138) (P26260)
Organism: Rattus norvegicus (Rat)
Function: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Subcellular location: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:P18827}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P18827}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000250|UniProtKB:P18827}.
Sequence: MRRAALWLWLCALALRLQPALPQIVTANVPPEDQDGSGDDSDNFSGSGTGALPDMTLSRQTPSTWKDVWLLTATPTAPEPTSRDTEATLTSILPAGEKPEEGEPVAHVEAEPDFTARDKEKEATTRPRETTQLPVTQQASTAARATTAQASVTSHPHGDVQPGLHETLAPTAPGQPDHQPPSVEDGGTSVIKEVVEDETTNQLPAGEGSGEQDFTFETSGENTAVAGVEPDLRNQSPVDEGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVAFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
InterPro domains: - IPR001050: Syndecan (family) [25-313]
- IPR027789: Syndecan/Neurexin domain (domain) [249-311]
- IPR030479: Syndecan, conserved site (conserved_site) [279-289]
- IPR003585: Neurexin/syndecan/glycophorin C (domain) [278-296]
Interaction partners: - Fibroblast growth factor 2
- Glypican-1
- Syndecan-4
- Syndecan-2
- Matrix metalloproteinase-9
- Heparanase
- Uncharacterized protein.
- Fibronectin
- Thrombospondin-2
- Thrombospondin-4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0051129 (negative regulation of cellular component organization), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0060627 (regulation of vesicle-mediated transport), GO:0002694 (regulation of leukocyte activation), GO:0001817 (regulation of cytokine production), GO:0010817 (regulation of hormone levels), GO:0050867 (positive regulation of cell activation), GO:0046883 (regulation of hormone secretion), GO:0031348 (negative regulation of defense response), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0010941 (regulation of cell death), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0050865 (regulation of cell activation), GO:1903532 (positive regulation of secretion by cell), GO:0043300 (regulation of leukocyte degranulation), GO:0031347 (regulation of defense response), GO:0050728 (negative regulation of inflammatory response), GO:0043254 (regulation of protein-containing complex assembly), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0033003 (regulation of mast cell activation), GO:0060284 (regulation of cell development), GO:0002793 (positive regulation of peptide secretion), GO:1901214 (regulation of neuron death), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:0051960 (regulation of nervous system development), GO:2001233 (regulation of apoptotic signaling pathway), GO:0045921 (positive regulation of exocytosis), GO:0050714 (positive regulation of protein secretion), GO:0010468 (regulation of gene expression), GO:0030855 (epithelial cell differentiation), GO:2000177 (regulation of neural precursor cell proliferation), GO:0048679 (regulation of axon regeneration), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:1903201 (regulation of oxidative stress-induced cell death), GO:0050727 (regulation of inflammatory response), GO:0090087 (regulation of peptide transport), GO:0031346 (positive regulation of cell projection organization), GO:0032715 (negative regulation of interleukin-6 production), GO:0051046 (regulation of secretion), GO:0031345 (negative regulation of cell projection organization), GO:0060429 (epithelium development), GO:0010721 (negative regulation of cell development), GO:0030182 (neuron differentiation), GO:0042981 (regulation of apoptotic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0043066 (negative regulation of apoptotic process), GO:0010976 (positive regulation of neuron projection development), GO:0043523 (regulation of neuron apoptotic process), GO:0002065 (columnar/cuboidal epithelial cell differentiation), GO:0042063 (gliogenesis), GO:0043524 (negative regulation of neuron apoptotic process), GO:1902692 (regulation of neuroblast proliferation), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:1903305 (regulation of regulated secretory pathway), GO:0010608 (post-transcriptional regulation of gene expression), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0030424 (axon)