Protein: DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3) (Q8T8S1)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cell membrane {ECO:0000269|PubMed:26792857}. Note=Predominantly localizes to the cell membrane in eye imaginal disk cells. {ECO:0000269|PubMed:26792857}.
Sequence: MGNCLKCFQSAAEQSMPTNASSPNSHNSNSNACQTATSLANCYESVGINPNANERCALETDELLSSRTPLKPAKANNCDTKRNSFKSLGLLNGSAPTMSDIITTAVQESMEVSHQTLSKLFDVYKDPDDEEMILTDGIERLCNDLNYQPDEFAILVLAWCLDASQMCRFTKVEFIEGLHKMRADTIDSIRVRLEQTIEMLKADAEMFKQLYRFTFRFGLEPDQRVLSLEMAIDLWKLVFTVQTPDLFSNWIHFLEKHPNIRRIPKDTWNMYLNFTEQCDIQNYDDTEAWPSLFDDFVDYEKSRALVSSGIHDDDNNNDDPLQSHVKAEDPGLVS
InterPro domains: - IPR042460: DCN1-like, PONY binding domain (homologous_superfamily) [203-308]
- IPR014764: Defective-in-cullin neddylation protein (family) [107-303]
- IPR005176: Potentiating neddylation domain (domain) [112-301]
Interaction partners: - Nedd8-conjugating enzyme UbcE2M
- Cullin homolog 1
- RING-box protein 1A
- IP10645p
- Ubiquitin-like protein NEDD8
- LD21810p
- Cullin 3, isoform F
- Cullin 6
- RING-box protein 1B
- Cullin-5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0097602 (cullin family protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0009893 (positive regulation of metabolic process), GO:0006950 (response to stress), GO:0048525 (negative regulation of viral process), GO:0051707 (response to other organism), GO:0009892 (negative regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009894 (regulation of catabolic process), GO:0043207 (response to external biotic stimulus), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009617 (response to bacterium), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0098542 (defense response to other organism), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0042742 (defense response to bacterium), GO:0051248 (negative regulation of protein metabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)