wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Basic amino-acid permease (P38971)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: High-affinity permease for basic amino acids.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MDETVNIQMSKEGQYEINSSSIIKEEEFVDEQYSGENVTKAITTERKVEDDAAKETESSPQERREVKRKLKQRHIGMIALGGTIGTGLIIGIGPPLAHAGPVGALISYLFMGTVIYSVTQSLGEMVTFIPVTSSFSVFAQRFLSPALGATNGYMYWLSWCFTFALELSVLGKVIQYWTEAVPLAAWIVIFWCLLTSMNMFPVKYYGEFEFCIASIKVIALLGFIIFSFCVVCGAGQSDGPIGFRYWRNPGAWGPGIISSDKNEGRFLGWVSSLINAAFTYQGTELVGITAGEAANPRKALPRAIKKVVVRILVFYILSLFFIGLLVPYNDPKLDSDGIFVSSSPFMISIENSGTKVLPDIFNAVVLITILSAGNSNVYIGSRVLYSLSKNSLAPRFLSNVTRGGVPYFSVLSTSVFGFLAFLEVSAGSGKAFNWLLNITGVAGFFAWLLISFSHIRFMQAIRKRGISRDDLPYKAQMMPFLAYYASFFIALIVLIQGFTAFAPTFQPIDFVAAYISIFLFLAIWLSFQVWFKCRLLWKLQDIDIDSDRRQIEELVWIEPECKTRWQRVWDVLS
InterPro domains: - IPR050524: Amino Acid-Polyamine-Organocation Superfamily YAT (family) [48-570]
- IPR004762: Amino acid permease, fungi (family) [67-545]
- IPR004841: Amino acid permease/ SLC12A domain (domain) [74-539]
- IPR004840: Amino acid permease, conserved site (conserved_site) [99-130]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0005342 (organic acid transmembrane transporter activity), GO:0046943 (carboxylic acid transmembrane transporter activity), GO:0015171 (amino acid transmembrane transporter activity), GO:0015174 (basic amino acid transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015849 (organic acid transport), GO:0006865 (amino acid transport), GO:0015711 (organic anion transport), GO:0015802 (basic amino acid transport), GO:0046942 (carboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0032126 (eisosome), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chloride channel protein (Q8LPA1)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
Sequence: SGSAGEPLLRKRTMNTTSQIAIVGANVCPIESLDYEVVENDLFKQDWRSRKKKQIFQYIVLKWTLVLLIGLLTGLVGFFNNLAVENIAGFKLLLTGNLMLKGKCRYLTAFFAYGGCNLVLAAAAAAICAYIAPAAAGSGIPEVKAYLNGVDAYSILAPSTLFVKIFGSILGVSAGFVLGKEGPMVHTGACIANLLGQGGSRKYRLTCNWLRYFKNDRDRRDLITCGSAAGVAAAFRAPVGGVLFALEEAASWWRSALLWRAFFTTAVVAVVLRSLIEFCRSGKCGLFGQGGLIMFDLSSTVATYSTPDLIAIIILGIIGGIFGGLFNFLLDKVLRVYSIINERGAPFKILLTITISIITSMCSYGLPWLAACTPCPVDAVEQCPTIGRSGNFKNFQCPPGHYNDLASLFFNTNDDAIRNLFSNGTESEFHMSTLFIFFTAVYCLGILTYGVAVPSGLFIPVILAGATYGRIVGTLLGSISDLDPGLFALLGAASFLGGTMRMTVSVCVILLELTNDLAMLPLVMLVLLISKTIADNFNKGVYDQIVVMKGLPYMEAHAEPYMRHLVAGDVVSGPLITFSGVEKVGNIVHALRFTGHNGFPVVDEPPLTEAPELVGLVTRSHLLVLLNGKMFMKDQLKTSGSFVLQRFGAFDFAKPGSGKGLKIQDLDFTDEEMEMYVDLHPVTNTSPYTVVETMSLAKAAILFRALGLRHLLVVPKTPDRPPIVGILTRHDFVEEHIHGLFPNLNPHKFHSTSMGG
InterPro domains: - IPR001807: Chloride channel (family) [121-555]
- IPR014743: Chloride channel, core (homologous_superfamily) [40-556]
- IPR046342: CBS domain superfamily (homologous_superfamily) [555-739]
- IPR002251: Chloride channel ClC-plant (family) [36-421]
- IPR051280: Voltage-gated chloride channel/antiporter (family) [10-738]
- IPR000644: CBS domain (domain) [574-743]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0098661 (inorganic anion transmembrane transport), GO:0015698 (inorganic anion transport), GO:0071705 (nitrogen compound transport), GO:1902025 (nitrate import), GO:0015706 (nitrate transmembrane transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0016020 (membrane), GO:0005773 (vacuole), GO:0031090 (organelle membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005774 (vacuolar membrane), GO:0009705 (plant-type vacuole membrane)
Protein: High-affinity lysophosphatidic acid receptor homolog (O43898)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: MACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVDRFLIIVQRQDKLNPRRAKVIIAVSWVLSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYVVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSDSLDLRQLTRAGLRRLQRQQQVSVDLSFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYCCNENQSAV
InterPro domains: - IPR051880: G-protein Coupled Orphan Receptors (family) [2-373]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [51-328]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [36-336]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0007267 (cell-cell signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0099536 (synaptic signaling), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007187 (G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0099537 (trans-synaptic signaling), GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway), GO:0098916 (anterograde trans-synaptic signaling), GO:0007268 (chemical synaptic transmission)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: FAD-binding PCMH-type domain-containing protein (C8VCU1)
Organism: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Function: Not known
Sequence: MALFLTGYLLLTFTLTLSFSTLRVWAAGRWPDVVAQELGPQLSSLASIITEPGAVESDFERWSAYSAPQPGVVVSVATEEDVAKTVKFCVSNSIRFLAQNGGHGWADTFDLGPNRRGLLIDITQLNTVVFNANRTQVTLGGGVSIGEAVAAAVEHDTLIPTGNCNCVGTLGAILGGGYGNLLGMVGFGVDNVLELKVVLADGEVHTVTPGRQGKDHDLFWALRGAGPNYGIVTSATLKAYPVDSATNITAWMGQLVFSGEQVEAVVQAIEELTLTPEMNIFLYYMTVNGTQRFIATPFYYGDEGEARGRAAFASLLDIGPIEDQTAEVPYARWNDGSDGFCTSGGYKPAYSAALQTQNSVVIMEAYSLDRARALPDDSAAFPGRSRVNFQAVAIPWYYDQGLENSAIAWGETMRALWWETDGLDDPAVYVNFAHGDENLTTIYGENVGQLRAIKARVDPENVFNQWFNLGTGRP
InterPro domains: - IPR050416: FAD-linked Oxidoreductases in Biosynthetic Pathways (family) [57-464]
- IPR016167: FAD-binding, type PCMH, subdomain 1 (homologous_superfamily) [51-126]
- IPR006094: FAD linked oxidase, N-terminal (domain) [70-207]
- IPR016166: FAD-binding domain, PCMH-type (domain) [66-242]
- IPR016169: FAD-binding, type PCMH, subdomain 2 (homologous_superfamily) [140-458]
- IPR012951: Berberine/berberine-like (domain) [428-464]
- IPR036318: FAD-binding, type PCMH-like superfamily (homologous_superfamily) [51-242]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0009404 (toxin metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009403 (toxin biosynthetic process), GO:0045460 (sterigmatocystin metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0045461 (sterigmatocystin biosynthetic process), GO:1901378 (organic heteropentacyclic compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Glutathione S-transferase 1 (EC 2.5.1.18) (GST-I) (P40582)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not known
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein.
Sequence: MSLPIIKVHWLDHSRAFRLLWLLDHLNLEYEIVPYKRDANFRAPPELKKIHPLGRSPLLEVQDRETGKKKILAESGFIFQYVLQHFDHSHVLMSEDADIADQINYYLFYVEGSLQPPLMIEFILSKVKDSGMPFPISYLARKVADKISQAYSSGEVKNQFDFVEGEISKNNGYLVDGKLSGADILMSFPLQMAFERKFAAPEDYPAISKWLKTITSEESYAASKEKARALGSNF
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [4-90]
- IPR036282: Glutathione S-transferase, C-terminal domain superfamily (homologous_superfamily) [101-226]
- IPR004046: Glutathione S-transferase, C-terminal (domain) [122-217]
- IPR010987: Glutathione S-transferase, C-terminal-like (domain) [96-234]
- IPR040079: Glutathione transferase family (family) [11-215]
- IPR004045: Glutathione S-transferase, N-terminal (domain) [3-90]
Interaction partners: - Peroxiredoxin PRX1, mitochondrial
- Glutathione reductase
- Glutathione hydrolase proenzyme
- Transcriptional regulator URE2
- Glutathione synthetase GSH2
- Glutathione-specific gamma-glutamylcyclotransferase
- Glutathione S-transferase 2
- Glutathione S-transferase omega-like 2
- Glutathione S-transferase omega-like 3
- Glutathione S-transferase omega-like 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups), GO:0004364 (glutathione transferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006082 (organic acid metabolic process), GO:0006631 (fatty acid metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0006633 (fatty acid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Peptidoglycan-binding LysM domain-containing protein (Q8VYP8)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Sequence: MLTERGRRISGFNGSFEFSNRKFRGYGFVDRSQGFHERSPSRSCSVSKILRITPPTSSPPSSASTCAGYIEHRVSKFDTLAGIAIKYGVEVADITKLNGLVTDLQMFALESLRIPLPGRHPPSPCLSNGSLNHGEDWSEQASSSASNGNHQDVFDSFQSLRLNHSEKKISPAMNSLQGYYGLKPKNRRASEGFGMAVYKNEASQLQDNDQYLTPFPATSTPLSHHRKSRSLVDAVIAEVNQSPNPSKAGGGEVNSTDKPMRRRQKSEADFSSRAPELLLKEENRSSSGAFSAIAGKNLALRSKASSRANLSAETRHLNSIPINLMDAPVGDSFSSVRKSVSASSLQEPNCNSNGSSLWPTSKWTLKPELLTQVAMASSIFDGLPKPLTGRRNKKAVD
InterPro domains: - IPR036779: LysM domain superfamily (homologous_superfamily) [48-121]
- IPR018392: LysM domain (domain) [70-115]
- IPR045030: LysM and putative peptidoglycan-binding domain-containing protein 1-4 (family) [50-310]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0050832 (defense response to fungus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Intermediate filament protein B (IF-B) (P23731)
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Function: Not known
Subcellular location: Cytoplasm.
Sequence: SLKQSQESSEYEIAYRSTIQPRTAVRTQSRQSGAYSTGAVSGGGGRVLKMVTEMGSASIGGISPALSANAAKSFLEATDKEKKEMQGLNDRLGNYIDRVKKLEEQNRKLVADLDELRGRWGKDTSEIKIQYSDSLRDARKEIDDGARRKAEIDVKVARLRDDLAELRNRYEDVQHRRESDREKINQWQHAIEDAQSELEMLRARWRQLTEEEKRLNGDNARIWEELQKARNDLDEETLGRIDFQNQVQTLMEELEFLRRVHEQEVKELQALLAQAPADTREFFKNELALAIRDIKDEYDYIAKQGKQDMESWYKLKVSEVQGSANRANMESSYQREEVKRMRDNIGDLRGKLGDLEAKNALLEKEVQNLNYQLNDDQRQYEAALNDRDATLRRMREECQTLVAELQALLDTKQMLDAEIAIYRKMLEGEESRVGLRQMVEQVVKTHSLQQQEDTDSTRNVRGEVSTKTTFQRSAKGNVTISECDPNGKFITLENTHRSKDENLGEHRLKRKLDNRREIVYTIPPNTVLKAGRTMKIYARDQGGIHNPPDTLVFDGENTWGIGANVVTSLINKDGDERATHTQKTIQTGQ
InterPro domains: - IPR039008: Intermediate filament, rod domain (domain) [80-433]
- IPR016451: Intermediate filament, ifa/ifb (family) [2-588]
- IPR001322: Lamin tail domain (domain) [466-584]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [419-427]
- IPR036415: Lamin tail domain superfamily (homologous_superfamily) [441-587]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045177 (apical part of cell), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane)
Protein: Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) (P61779)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00278}.
Sequence: MLAILDYKAGNQTSVRRALDHLGIPCVITADPEVIQGAAGVIFPGVGAAGQAMNELVTTGLDEVLRRQVQAGRPLLGICVGCQIMLDYSQENDTKALGIIPGECRLFNPAWTDEDGAPIRVPHMGWNHIVQRRPCELLKGIEPEAEFYFVHSYYPAPPEEYVIATCTYGAEFCAIHGGPGLWAVQFHPEKSGRPGLRLLANFHRYCTEAADAQ
InterPro domains: - IPR010139: Imidazole glycerol phosphate synthase, subunit H (family) [1-208]
- IPR029062: Class I glutamine amidotransferase-like (homologous_superfamily) [1-212]
- IPR017926: Glutamine amidotransferase (domain) [4-202]
Interaction partners: - Imidazole glycerol phosphate synthase subunit HisF
- 1-
- Imidazoleglycerol-phosphate dehydratase
- Histidinol-phosphate aminotransferase
- Phosphoribosyl-AMP cyclohydrolase
- Histidinol dehydrogenase
- ATP phosphoribosyltransferase
- Aminotransferase, putative
- Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative
- Adenylosuccinate lyase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010646 (regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0030111 (regulation of Wnt signaling pathway), GO:0030178 (negative regulation of Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Ribosome-binding protein 1 (180 kDa ribosome receptor homolog) (RRp) (ES/130-related protein) (Ribosome receptor protein) (Q9P2E9)
Organism: Homo sapiens (Human)
Function: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.
Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Sequence: MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRAPAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTSKAAILETAPKEVPMVVVPPVGAKGNTPATGTTQGKKAEGTQNQSKKAEGAPNQGRKAEGTPNQGKKTEGTPNQGKKAEGTPNQGKKAEGTPNQGKKAEGAQNQGKKVDTTPNQGKKVEGAPTQGRKAEGAQNQAKKVEGAQNQGKKAEGAQNQGKKGEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGQKGEGAQNQGKKTEGAQGKKAERSPNQGKKGEGAPIQGKKADSVANQGTKVEGITNQGKKAEGSPSEGKKAEGSPNQGKKADAAANQGKKTESASVQGRNTDVAQSPEAPKQEAPAKKKSGSKKKGEPGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALEAKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLLSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLAREKDTVKKLQEQLEKAEDGSSSKEGTSV
InterPro domains: - IPR040248: Ribosome-binding protein 1 (family) [575-1410]
- IPR007794: Ribosome receptor lysine/proline rich (domain) [33-1359]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)