Protein: Pentalenolactone synthase (EC 1.14.19.8) (Pentalenolactone biosynthesis protein M) (E3VWI3)
Organism: Streptomyces arenae
Function: Catalyzes the final step in the biosynthesis of the sesquiterpenoid antibiotic pentalenolactone by mediating the oxidative rearrangement of pentalenolactone F to pentalenolactone.
Sequence: MTDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [1-398]
- IPR017972: Cytochrome P450, conserved site (conserved_site) [340-349]
- IPR001128: Cytochrome P450 (family) [232-367]
- IPR002397: Cytochrome P450, B-class (family) [88-358]
- IPR054976: Pentalenolactone synthase (family) [3-398]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0043169 (cation binding), GO:0046906 (tetrapyrrole binding), GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors), GO:0020037 (heme binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0018904 (ether metabolic process), GO:1901334 (lactone metabolic process), GO:1901503 (ether biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006720 (isoprenoid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:1901336 (lactone biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0006721 (terpenoid metabolic process), GO:0016114 (terpenoid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0016106 (sesquiterpenoid biosynthetic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0006714 (sesquiterpenoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)