Protein: Tyrosine kinase-like protein (EC 2.7.10.2) (Q8IDK6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MSEHSSGVSRKLFCNSDKLFYDNFRNLDDRLNLNNNFNENRYEEIYNKKYLRNNRRFKTEPPKHLYENESEQSYSSLFHNILRSISKNIRNDEKEESSDNNNCDDDNDNNNDDDDNNNQSDSIPNNSENFNYDDNSCCEISPYDEISKKTKRVHNKIHKNEDGEYYKNVLYNNNNLSKENQINNICSSINKTQRTLKRIDTNINETLNNVKYIKMVNSDIISDVFLKNNVKSLIVYDTGGIDIELIENENPEFLYHTYTGNRISNIYYEYDDCIKNKDTYKNEEKKKKKNTFNSSLLYRENYIFKKEHELNYCYKNKDDNKKKIKNNPSEKNQIMNYSSDICSNSDSKKLFTKNKKQENVINKNIYYNNPSDYNILNNEVNYNKNTVHNTNLSKDTCEHTYKNVSNKYDIQDHNTNSSAEKYYNMNYKSSLLNKNDKYIENTSSERNKGYRSYSSMSSMLSLNAYEKENRKKYYYIGETINNIRNGWGMLIYNDRVIFEGEYKMNNAIGYFIKYNEYSTEIGYRSPISVKSVIIMSDNDNFIVQNRSENLDTSKNKEQKSGNNSWNVYKYDNDNSDHNDDSDDNGDSDDNGDSDYNNENIYNNENILNNENIYNNENILNNENILNNENILNNENIYNNENIYNNENIYNNENIHNNENIHNNENIHNNENIHNNENIHNNENIHNNENIYNHHSNDSSGENIRDSFSKNNIKNISKDTYKINNNENINNLDKNVPIYDNSSNSINNCSYYINSKYANKSSSNKGNKMISKHSTLKNSSCINNDIKNIKFSENPEENAKELKKFNNLTSYVRRNSKHKTSPARSINYLKPPVMNLIRNNIYFNRNTLGKNDKTTFCTSNIHSSNKKMREHKTTHFLSPMNIIVTSLDTDDEDNISDDNGKTDVISSCTQYEEERKKDEQNIKTEEVQYIETYMKDNDTRVLYELKINKNDDILSNHKTNESIFEKKDFKKYEEIYNNDYDHQNIIKTVCSKNDNNIDNVKNMKSVDIYDTNKKNYNRNYMNNLDNANNFDEPTNNTFEKYVKKNEGEELIFNDDQNKLHIDTFEKYKYLICENINNDKFVIKNNQITTFEKFLKNQQNFEINNKWRDTLNKIKSQNNSMRQFMQPKINNYNLCKYYVCSNNIEQIKKGALWNNTRLMGDIIKTKRENNNILNGDILNGDIINGDILNNDILNKDILNNDSLNNDSLNNDSLNNDSLNNDILNNDIPNSDVSSNVHNISSEYLNNNDKENMKFCKWGRNIFARRLRGATFPETHDDRQKHCFLFIDDYLTSNENKFDIINQNVKLRASDYNKWSVNMLYNFLKMIGLKKEAYLFKINKIRGYHILKLTDKELKKLNINNSYVRKFVLSVFRFLTNSIDNADPLSLNYNSNKKFSFNNIENICNTHITILNKIGGGSYAQVFRAKYKTIHVACKIFLYKPKDLAEESYCESYISTPRSSHRYIFPKINKNINGEDYKNTDMNNEKRKDQNIFTDNFHMDESSSMQHVPHVDDINYIEQEDNIENNTKYKNKKNNNDINNSSDTLQRNKKIKKMANLEIFRYFPTPVKYRNYEAKILYSLRECKHVIKLIGVCSLREGEESLILQHCPGGSLEKYIYKDEKKKNSPYAKSLTRPKLVKIFQQVAEGMYNIHTNQCFHRDLKLSNILLDENQNAVISDFGLSTNFSSNDSPTAYAIYGNIFYAAPEVLKGEGFFKESDVWSFAVSLWEALTKKIAYDGISASEVFCKISSGELFLPIPKDIPMELSELLKSMLEYDFTKRPLFNVIAKKLEQIRIQAEDKLHLDIMSFFDG
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1396-1789]
- IPR001660: Sterile alpha motif domain (domain) [1312-1375]
- IPR013761: Sterile alpha motif/pointed domain superfamily (homologous_superfamily) [1307-1374]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [1652-1664]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [1570-1786]
- IPR017441: Protein kinase, ATP binding site (binding_site) [1411-1432]
- IPR000719: Protein kinase domain (domain) [1405-1791]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [1570-1792]
Interaction partners: - Gametocyte-specific protein
- non-specific serine/threonine protein kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0008289 (lipid binding), GO:0043167 (ion binding), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0005543 (phospholipid binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0043168 (anion binding), GO:0035091 (phosphatidylinositol binding), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding), GO:0070300 (phosphatidic acid binding), GO:1901981 (phosphatidylinositol phosphate binding), GO:1902936 (phosphatidylinositol bisphosphate binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0044238 (primary metabolic process), GO:0051701 (biological process involved in interaction with host), GO:1901576 (organic substance biosynthetic process), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0075136 (response to host), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0005975 (carbohydrate metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0052200 (response to host defenses), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010468 (regulation of gene expression), GO:0044264 (cellular polysaccharide metabolic process), GO:0006073 (cellular glucan metabolic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0044042 (glucan metabolic process), GO:0000271 (polysaccharide biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0044042 (glucan metabolic process), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0009250 (glucan biosynthetic process), GO:0005982 (starch metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0005773 (vacuole), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005764 (lysosome)