Protein: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (P0C089)
Organism: Rattus norvegicus (Rat)
Function: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Sequence: MAASAWLEAGLARVLFYPTLLYTVFRGRVGGPAHRDWYHRIDHTVLLGALPLRSMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKNVGVEQLRLSTVDMTGVPTLANLHRGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIEAIAKIRSHISIRPSQLEILKEFHKEIAARAAKN
InterPro domains: - IPR042165: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (family) [2-192]
- IPR016130: Protein-tyrosine phosphatase, active site (active_site) [130-140]
- IPR000387: Tyrosine-specific protein phosphatases domain (domain) [109-177]
- IPR044596: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1-like (family) [37-185]
- IPR029021: Protein-tyrosine phosphatase-like (homologous_superfamily) [34-193]
- IPR020422: Dual specificity protein phosphatase domain (domain) [37-188]
- IPR000340: Dual specificity phosphatase, catalytic domain (domain) [71-184]
Interaction partners: - Phosphatidate cytidylyltransferase, mitochondrial
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity), GO:0034595 (phosphatidylinositol phosphate 5-phosphatase activity), GO:0106019 (phosphatidylinositol-4,5-bisphosphate phosphatase activity), GO:0004439 (phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023057 (negative regulation of signaling), GO:0051051 (negative regulation of transport), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:1903828 (negative regulation of protein localization), GO:0060341 (regulation of cellular localization), GO:0051224 (negative regulation of protein transport), GO:0010817 (regulation of hormone levels), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0046883 (regulation of hormone secretion), GO:0061179 (negative regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0070201 (regulation of establishment of protein localization), GO:0002792 (negative regulation of peptide secretion), GO:0050709 (negative regulation of protein secretion), GO:0051046 (regulation of secretion), GO:0032880 (regulation of protein localization), GO:0050708 (regulation of protein secretion), GO:1904950 (negative regulation of establishment of protein localization), GO:0090278 (negative regulation of peptide hormone secretion), GO:0046676 (negative regulation of insulin secretion), GO:0002791 (regulation of peptide secretion), GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus), GO:0050796 (regulation of insulin secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)