Protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (D4A1J9)
Organism: Rattus norvegicus (Rat)
Function: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Sequence: MEKFLFYLFLIGIAVRAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWLRRLSREDDLETCASPALLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQTMDLHIIKLPHLLNSTNNIHEPDPGSSDISTSTKSGSNASSSNGDTKMSQDKIVVAEASSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTLVYRMIPPTSKTFLVNNLASGTMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQMQGCSVTLPQSMSKQAMGHEENAQCCKVASDSAIQSSETCSSQDSSTTTSALPPTWTSSAPVSQKQKRKTGTKPSAEPQSEAVTNVESQNTNRNNSTALQLASCPPDSVTEGPTSQRAHTKPNALLTNVDQNVQETQRLESI
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [17-282]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [422-495]
- IPR050467: Leucine-rich repeat and fibronectin type-III domain-containing (family) [8-645]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [284-374]
- IPR013098: Immunoglobulin I-set (domain) [289-374]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [283-376]
- IPR007110: Immunoglobulin-like domain (domain) [287-373]
- IPR003598: Immunoglobulin subtype 2 (domain) [299-364]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [74-218]
- IPR001611: Leucine-rich repeat (repeat) [99-213]
- IPR003599: Immunoglobulin domain subtype (domain) [293-375]
Interaction partners: - Interleukin-1 receptor accessory protein-like 1
- Adhesion G protein-coupled receptor L3
- Adhesion G protein-coupled receptor L1
- Adhesion G protein-coupled receptor L2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065008 (regulation of biological quality), GO:0050793 (regulation of developmental process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0050803 (regulation of synapse structure or activity), GO:2000026 (regulation of multicellular organismal development), GO:0051129 (negative regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051961 (negative regulation of nervous system development), GO:0044087 (regulation of cellular component biogenesis), GO:1905809 (negative regulation of synapse organization), GO:0051964 (negative regulation of synapse assembly), GO:0051960 (regulation of nervous system development), GO:0050807 (regulation of synapse organization), GO:1901888 (regulation of cell junction assembly), GO:1901889 (negative regulation of cell junction assembly), GO:0051963 (regulation of synapse assembly), GO:0099174 (regulation of presynapse organization), GO:1905606 (regulation of presynapse assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0071944 (cell periphery), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:0045202 (synapse), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0099634 (postsynaptic specialization membrane), GO:0098984 (neuron to neuron synapse), GO:0014069 (postsynaptic density), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane)