Protein: Espin (B0S4T9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell projection, stereocilium {ECO:0000256|ARBA:ARBA00004645}.
Sequence: MVVERTLLAARQGDVQTLKVQFAEKVLNGDVKDVLGATPVHHAARAGKLTCLRYLVDEAGLPANSLARNGASPAHDAAATGNLTCLQWLVTHGGCRAADKDSSGATVLHLASRFSHHEIIDWLLKSEEGDPTVATDTGALPVHYAAAKGDLPSLRLLLEHSPQVVNFQTKNGATPLYLACQEGHLEVVQYLVKDCGAEPSIRANDGMTPLHAAAQMGHNTVIVWLMSFTEISLSDRDNDGATAMHFAASRGHAKVLSWLLLHGGEIMTDSWGGTPLHDAAENGELECCQILVVNGVDLGIRDQDGFSAADLAEYNGHQQCAKYLRTVENMSVEHRVLSRDASADLEYKQPDSGLSSPNATLPNPAPPAGHFDICSPSSSLSNYDSANSSQSSTGEKRSGSPPSRVPTGGTDSAITDMQTYMDMLNPDEACGSHNAKEAAHLPPPPTFPPPPPPSNPSHIPPPPPAYPAPNPPEEEEVSAEYLKVKRNLRRVDNDVVKKELVIFRQQLNPGENHERLRRVDSNRKSRSFSKQPSTGDYYKTLGSDTTDQQPSRAMAPNEEGSALLEEAADTAPAPENGTGTTEDLPLPPPPPPPPASTFIPAPPPPPPLPSELPPPPPPSTTTPAAAQRRMSSSSNSNKSFNMMSPTGDNSELLAEIKAGKSLKPTPHSKGYTTVFSNSGTPGNNGESPSSPPEPLPKPNDTQSAKPESPPPACPPTPPNPTASRSSPQNLSTSQSSDQLTAAVNGNTSVVQNKTSVVDVESLVPTHDEQGRAIPEWKRQVMVRKLQVKMQEEEENKRKAEEEAARLASLPAWRRDIMKKKLEEEKKDEEQRRMEKESEEKSELERLRTLGYDETKLAPWQKQIILKKGDIAKQ
InterPro domains: - IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [2-333]
- IPR002110: Ankyrin repeat (repeat) [8-334]
- IPR052420: Espin and Espin-like domain-containing protein (family) [1-802]
- IPR003124: WH2 domain (domain) [648-665]
Interaction partners: - Myosin IIIB
- Myosin IIIA
- Whirlin b
- Whirlin
- Plastin 1
- Twinfilin-2
- TRIO and F-actin-binding protein b
- Myosin VIIAa
- Fascin.
- Epidermal growth factor receptor kinase substrate 8-like protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0030036 (actin cytoskeleton organization), GO:0030030 (cell projection organization), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0022607 (cellular component assembly), GO:0007010 (cytoskeleton organization), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0051017 (actin filament bundle assembly), GO:0061572 (actin filament bundle organization), GO:0030046 (parallel actin filament bundle assembly), GO:0032528 (microvillus organization), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0098862 (cluster of actin-based cell projections), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0005903 (brush border), GO:0032421 (stereocilium bundle), GO:0032420 (stereocilium), GO:0043228 (non-membrane-bounded organelle), GO:0098858 (actin-based cell projection), GO:0043005 (neuron projection), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)