Protein: Transmembrane protein 238-like (A6NJY4)
Organism: Homo sapiens (Human)
Function: May play a role in inducing apoptosis during endoplasmic reticulum (ER) stress and in the inhibition of proliferation and tumorigenicity
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MLLGSLWGRCHPGRCALFLILALLLDAVGLVLLLLGILAPLSSWDFFIYTGALILALSLLLWIIWYSLNIEVSPEKLDL
InterPro domains: - IPR029365: TMEM238 protein (family) [7-78]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0051235 (maintenance of location), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010942 (positive regulation of cell death), GO:0060548 (negative regulation of cell death), GO:0072593 (reactive oxygen species metabolic process), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0051668 (localization within membrane), GO:0009725 (response to hormone), GO:1901135 (carbohydrate derivative metabolic process), GO:0045184 (establishment of protein localization), GO:0046907 (intracellular transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0042391 (regulation of membrane potential), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:1903829 (positive regulation of protein localization), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009891 (positive regulation of biosynthetic process), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0080090 (regulation of primary metabolic process), GO:1901652 (response to peptide), GO:0009059 (macromolecule biosynthetic process), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0071702 (organic substance transport), GO:0010468 (regulation of gene expression), GO:1901566 (organonitrogen compound biosynthetic process), GO:0015031 (protein transport), GO:1902533 (positive regulation of intracellular signal transduction), GO:1900182 (positive regulation of protein localization to nucleus), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0061024 (membrane organization), GO:0071417 (cellular response to organonitrogen compound), GO:0009416 (response to light stimulus), GO:0043086 (negative regulation of catalytic activity), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0071310 (cellular response to organic substance), GO:0043068 (positive regulation of programmed cell death), GO:1901699 (cellular response to nitrogen compound), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:0032880 (regulation of protein localization), GO:2001233 (regulation of apoptotic signaling pathway), GO:0090150 (establishment of protein localization to membrane), GO:0034976 (response to endoplasmic reticulum stress), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0016197 (endosomal transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0008104 (protein localization), GO:0051338 (regulation of transferase activity), GO:0006996 (organelle organization), GO:0031328 (positive regulation of cellular biosynthetic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0042981 (regulation of apoptotic process), GO:0032006 (regulation of TOR signaling), GO:0042981 (regulation of apoptotic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051897 (positive regulation of protein kinase B signaling), GO:0043549 (regulation of kinase activity), GO:0051896 (regulation of protein kinase B signaling), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0043410 (positive regulation of MAPK cascade), GO:0031401 (positive regulation of protein modification process), GO:0043409 (negative regulation of MAPK cascade), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0006355 (regulation of DNA-templated transcription), GO:0008361 (regulation of cell size), GO:0019220 (regulation of phosphate metabolic process), GO:1903725 (regulation of phospholipid metabolic process), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:1904375 (regulation of protein localization to cell periphery), GO:1903078 (positive regulation of protein localization to plasma membrane), GO:0045936 (negative regulation of phosphate metabolic process), GO:0001932 (regulation of protein phosphorylation), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:1903076 (regulation of protein localization to plasma membrane), GO:0042326 (negative regulation of phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0042325 (regulation of phosphorylation), GO:0045893 (positive regulation of DNA-templated transcription), GO:0033674 (positive regulation of kinase activity), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903321 (negative regulation of protein modification by small protein conjugation or removal), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0045944 (positive regulation of transcription by RNA polymerase II), GO:0071900 (regulation of protein serine/threonine kinase activity), GO:0000122 (negative regulation of transcription by RNA polymerase II), GO:0031396 (regulation of protein ubiquitination), GO:0045860 (positive regulation of protein kinase activity), GO:0043405 (regulation of MAP kinase activity), GO:0071902 (positive regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)