wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Guanine/hypoxanthine permease GhxQ (Q46817)
Organism: Escherichia coli (strain K12)
Function: High-affinity transporter for guanine and hypoxanthine.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24214977}; Multi-pass membrane protein {ECO:0000269|PubMed:24214977}.
Sequence: MSGDILQTPDAPKPQGALDNYFKITARGSTVRQEVLAGLTTFLAMVYSVIVVPGMLGKAGFPPAAVFVATCLVAGFGSLLMGLWANLPMAIGCAISLTAFTAFSLVLGQQISVPVALGAVFLMGVIFTAISVTGVRTWILRNLPMGIAHGTGIGIGLFLLLIAANGVGMVIKNPIEGLPVALGAFTSFPVMMSLLGLAVIFGLEKCRVPGGILLVIIAISIIGLIFDPAVKYHGLVAMPSLTGEDGKSLIFSLDIMGALQPTVLPSVLALVMTAVFDATGTIRAVAGQANLLDKDNQIINGGKALTSDSVSSIFSGLVGAAPAAVYIESAAGTAAGGKTGLTATVVGALFLLILFLSPLSFLIPGYATAPALMYVGLLMLSNVSKLDFNDFIDAMAGLVCAVFIVLTCNIVTGIMLGFVTLVVGRVFAREWQKLNIGTVIITAALVAFYAGGWAI
InterPro domains: - IPR045018: Azaguanine-like transporters (family) [13-443]
- IPR006043: Nucleobase cation symporter 2 family (family) [32-415]
Interaction partners: - Xanthine permease XanQ
- Uric acid transporter UacT
- Putative purine permease YbbY
- Putative pyrimidine permease RutG
- Xanthine permease XanP
- Uracil permease
- Guanine deaminase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015205 (nucleobase transmembrane transporter activity), GO:0005345 (purine nucleobase transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0098739 (import across plasma membrane), GO:0006810 (transport), GO:0072530 (purine-containing compound transmembrane transport), GO:0071702 (organic substance transport), GO:0098657 (import into cell), GO:0071705 (nitrogen compound transport), GO:0015851 (nucleobase transport), GO:0006863 (purine nucleobase transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Larval cuticle protein 2 (Larval cuticle protein II) (P07187)
Organism: Drosophila melanogaster (Fruit fly)
Function: Component of the larval cuticle.
Sequence: MFKFVMILAVVGVATALAPVSRSDDVHADVLSRSDDVRADGFDSSLHTSNGIEQAASGDAHGNIHGNFGWISPEGEHVEVKYVANENGYQPSGAWIPTPPPIPEAIARAVAWLESHPPAPEHPRHH
InterPro domains: - IPR050468: Larval/pupal cuticle protein (family) [6-119]
- IPR000618: Insect cuticle protein (family) [39-100]
- IPR031311: Chitin-binding type R&R consensus (conserved_site) [66-91]
Interaction partners: - Larval cuticle protein 3
- Larval cuticle protein 4
- Larval cuticle protein 9
- Uncharacterized protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0042302 (structural constituent of cuticle)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042303 (molting cycle), GO:0009791 (post-embryonic development), GO:0007591 (molting cycle, chitin-based cuticle), GO:0002165 (instar larval or pupal development), GO:0002164 (larval development), GO:0042335 (cuticle development), GO:0040003 (chitin-based cuticle development), GO:0002168 (instar larval development), GO:0042337 (cuticle development involved in chitin-based cuticle molting cycle), GO:0008363 (larval chitin-based cuticle development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: U1 small nuclear ribonucleoprotein C (U1 snRNP C) (U1-C) (U1C) (D3ZCL3)
Organism: Rattus norvegicus (Rat)
Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subcellular location: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153}.
Sequence: MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQGKIPPAPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAPGMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR
InterPro domains: - IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [1-59]
- IPR013085: U1-C, C2H2-type zinc finger (domain) [1-38]
- IPR000690: Matrin/U1-C, C2H2-type zinc finger (domain) [4-36]
- IPR003604: Matrin/U1-C-like, C2H2-type zinc finger (domain) [1-37]
- IPR017340: U1 small nuclear ribonucleoprotein C (family) [1-159]
Interaction partners: - Small nuclear ribonucleoprotein Sm D3
- U1 small nuclear ribonucleoprotein A
- Small nuclear ribonucleoprotein-associated protein N
- Small nuclear ribonucleoprotein Sm D1
- U1 small nuclear ribonucleoprotein 70 kDa
- Small nuclear ribonucleoprotein F
- Small nuclear ribonucleoprotein Sm D2
- Small nuclear ribonucleoprotein G
- Small nuclear ribonucleoprotein polypeptide A'
- Small nuclear ribonucleoprotein Sm D2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0043169 (cation binding), GO:0003677 (DNA binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0003727 (single-stranded RNA binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0010941 (regulation of cell death), GO:0010942 (positive regulation of cell death), GO:0043067 (regulation of programmed cell death), GO:0043068 (positive regulation of programmed cell death), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) (Q93NB6)
Organism: Yersinia pestis
Function: Not known
Sequence: METKDLIVIGGGINGAGIAADAAGRGLSVLLLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKLAPHIAFPMRFRLPHQPHLRPAWMIRTGLFLYDHLGKRTSLPASKGLRFGPESVLKPELVRGFEYSDCWVDDARLVVLNVQEVVKHGGEVRTRTKVTRTWREQGLWMVEALDVNTGKTFTWRAKGLVNATGP
InterPro domains: - IPR006076: FAD dependent oxidoreductase (domain) [5-208]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [1-208]
- IPR000447: FAD-dependent glycerol-3-phosphate dehydrogenase (family) [3-208]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0016491 (oxidoreductase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:1901265 (nucleoside phosphate binding), GO:0050660 (flavin adenine dinucleotide binding), GO:0071949 (FAD binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0120252 (hydrocarbon metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0042214 (terpene metabolic process), GO:0120251 (hydrocarbon biosynthetic process), GO:0008299 (isoprenoid biosynthetic process), GO:0008610 (lipid biosynthetic process), GO:0051761 (sesquiterpene metabolic process), GO:0046246 (terpene biosynthetic process), GO:0051762 (sesquiterpene biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Serine/threonine/tyrosine-protein kinase HT1 (EC 2.7.10.1) (EC 2.7.11.1) (High leaf temperature protein 1) (Q2MHE4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Serine/threonine/tyrosine kinase involved in the control of stomatal movement in response to CO(2). Functions as a major negative regulator of CO(2)-induced stomatal closing. Does not seem to be involved in stomatal closure in response to abscisic acid (ABA) or light. Involved in the control of red light-induced stomatal opening. Is epistatic to SRK2E/OST1 function during stomatal responses to red light and altered CO(2). Phosphorylates SRK2E/OST1 and GHR1 to prevents SRK2E/OST1- and GHR1-induced activation of SLAC1, thus preventing stomatal closure.
Subcellular location: Cell membrane {ECO:0000269|PubMed:25599916}.
Sequence: MSGLCFNPFRLRWSLRSKLPLEPSLPNLPCNPSSSKTNRYAEAETMEKKRFDSMESWSMILESENVETWEASKGEREEWTADLSQLFIGNKFASGAHSRIYRGIYKQRAVAVKMVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHSQGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSENPSKRPDFSNIVAVLEKYDECVKEGLPLTSHASLTKTKKAILDHLKGCVTSISSPFSSSSVPVNA
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [65-340]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [208-220]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [89-339]
- IPR000719: Protein kinase domain (domain) [86-359]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [79-343]
Interaction partners: - Protein DETOXIFICATION 56
- Guard cell S-type anion channel SLAC1
- Protein unc-13 homolog
- Beta carbonic anhydrase 4
- Aluminum-activated malate transporter 12
- Beta carbonic anhydrase 1, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0006970 (response to osmotic stress), GO:0001101 (response to acid chemical), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0006979 (response to oxidative stress), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:1902074 (response to salt), GO:0097305 (response to alcohol), GO:0009651 (response to salt stress), GO:0009737 (response to abscisic acid), GO:0033993 (response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Receptor expression-enhancing protein (A0A0B4KEX8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|RuleBase:RU362006}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU362006}.
Sequence: MRPIYQQEPPLFYQRPANLRRLRHPPGTVYGRSYSLEDQPEDVIPVYPKFIYAPQQQQQQQRAPYPLYQLGDSLSSLDSDFPENEYAGAYIVEDRVPLANAPTPKVVQNLNALGRMLELLQRCPLPCLSFNTACICSLIVIFLAPRTCAQSLLFPAFRLFCGTLYPAYASYKAVRTKDVKEYVKWMMYWIVFAFFTCIETFTDIFISWLPFYYEVKVALVFWLLSPATKGSSTLYRKFVHPMLTRHEQEIDEYVNQAKERGYSAVLQLGSKGVNYATNVLMQTAIKRRCIK
InterPro domains: - IPR004345: TB2/DP1/HVA22 (family) [158-286]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0033554 (cellular response to stress), GO:0034976 (response to endoplasmic reticulum stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Aquaporin (G5EEK0)
Organism: Caenorhabditis elegans
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}.
Sequence: MVSPYEEDSRPPYMSSYAEETWGQPATTNRKSSYTSRKKEYSLLTKCVAEFLGDLTFVYVGTMQASLFQYADGILHAAFAHGFTIFILVTAFGHISGGHFNPAVSWAIAGAGKMPIFHLPFYVVSQLLGGICGAFLTAAVLSQEQLTSCEAGATLLSPGSQWWQGLIAETVVTFFLVHTILITAADTDTVTLAPLAIGLTLSIDILSTGSITGASMNPARSLGPSIIGSIFATQKTSFYWNNHYIYWAGPLLGSTIALCIYKLFESREERIVR
InterPro domains: - IPR000425: Major intrinsic protein (family) [40-264]
- IPR034294: Aquaporin transporter (family) [38-265]
- IPR023271: Aquaporin-like (homologous_superfamily) [9-271]
Interaction partners: - Aquaporin-3
- Aquaporin
- Putative aquaporin-10
- Aquaporin-9
- Aquaporin-9
- Aquaporin
- F-box domain-containing protein
- Probable delta-1-pyrroline-5-carboxylate synthase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015267 (channel activity), GO:0005372 (water transmembrane transporter activity), GO:0015250 (water channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0042044 (fluid transport), GO:0006833 (water transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0036477 (somatodendritic compartment), GO:0042995 (cell projection), GO:0044297 (cell body), GO:0043025 (neuronal cell body), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium), GO:0097730 (non-motile cilium)
Protein: ADAM metallopeptidase domain 28 (A0A8I6A4L8)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MQQWRLLVVWFLLSPVPASAIKELPKAKNYEVVYPIRLHLLHKRETKEPEPKETFETELRYKMTVNGKVVELYLKKNNKLLAPGYLETYYNSSGNKVTTSPQIMDSCYYQGHIINEKDSAASISMCQGLRGYFSQADERYFIEPLSSEILDEQAHALFKDDPKEDQENSNCGVDDALWLQGLHQDVVLPATRLIKLNDGMVQEPKKYIEYYVVLDNGEFKKYNKNLDEIRKRVHEMANYVNMLYNKLDAHVALVGMEIWTDEDKIKITPDANTTLENFSKWRGNDLLKRKHHDVAQLISSTDFSGSTVGLAFMSSMCSPYHSVGIVQDHSNYHLRVAGTMAHEMGHNLGMIHDYLSCKCPSEVCVMEQSLRFHMPTDFSSCSRDNYRRFLEEKLSHCLFNSPLPSDIISTPVCGNQLLEMNEDCDCGTPKECTNKCCDAETCKIKAGFQCALGECCEKCQLKKPGVVCRAAKDECDLPEMCDGKSSHCPVDRFRVNGFPCQNGHGYCLKGNCPTLQQQCMDMWGPETKVANKSCYKQNEGGSKYGYCHVENGTHMPCKAKDAMCGKLFCEGGSGDLPWKGLTIAFLTCKLFDPEDINQGVDMVANGTKCGNNKVCINAECVDMEKTYKSANCSSKCKGHAVCDHELQCQCKEGWAPPDCEDSATVFRVSIMVGVLFPLAAIFVVIAIVIHHQSARRKQRRVQRLPPIKDAKLHKQKCRPQKVKDIQPQELITKPNFPPPPIPVS
InterPro domains: - IPR018358: Disintegrin, conserved site (conserved_site) [450-469]
- IPR001590: Peptidase M12B, ADAM/reprolysin (domain) [206-402]
- IPR001762: Disintegrin domain (domain) [410-496]
- IPR036436: Disintegrin domain superfamily (homologous_superfamily) [409-493]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [201-403]
- IPR006586: ADAM, cysteine-rich domain (domain) [495-623]
- IPR034027: Reprolysin domain, adamalysin-type (domain) [206-400]
- IPR000742: EGF-like domain (domain) [628-660]
- IPR002870: Peptidase M12B, propeptide (domain) [31-113]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0019953 (sexual reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007283 (spermatogenesis), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure), GO:0009986 (cell surface)
Protein: polynucleotide adenylyltransferase (EC 2.7.7.19) (Q9NDU2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MWNSEPTHRQHHQHNGNSTSGGPPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNTLVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFEVLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRSLNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGV
InterPro domains: - IPR043519: Nucleotidyltransferase superfamily (homologous_superfamily) [29-218]
- IPR048840: Poly(A) polymerase, nucleotidyltransferase domain (domain) [29-222]
- IPR007012: Poly(A) polymerase, central domain (domain) [227-255]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070566 (adenylyltransferase activity), GO:0004652 (polynucleotide adenylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0044248 (cellular catabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0090304 (nucleic acid metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0016070 (RNA metabolic process), GO:0006401 (RNA catabolic process), GO:0034661 (ncRNA catabolic process), GO:0034660 (ncRNA metabolic process), GO:0043631 (RNA polyadenylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Multivesicular body sorting factor 12 (12 kDa multivesicular body sorting factor) (ESCRT-I complex subunit MVB12) (P42939)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Appears to be involved in cargo sorting and release of the ESCRT-I complex from the MVBs.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:17135292}. Endosome {ECO:0000269|PubMed:17135292}. Late endosome membrane {ECO:0000305|PubMed:17135292}; Peripheral membrane protein {ECO:0000305|PubMed:17135292}.
Sequence: MNNNVEELLRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIVGNTLLSPSRKDNS
InterPro domains: - IPR019014: Multivesicular body sorting factor 12 (domain) [9-98]
Interaction partners: - Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
- Protein SRN2
- Vacuolar protein sorting-associated protein 28
- Vacuolar protein-sorting-associated protein 36
- Vacuolar protein-sorting-associated protein 25
- Vacuolar protein sorting-associated protein 20
- Vacuolar-sorting protein SNF8
- Vacuolar protein-sorting-associated protein 24
- DOA4-independent degradation protein 4
- Vacuolar-sorting protein SNF7
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0001510 (RNA methylation), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0034470 (ncRNA processing), GO:0036260 (RNA capping), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)