Protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Q9P1Z3)
Organism: Homo sapiens (Human)
Function: Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
Subcellular location: Cell membrane {ECO:0000269|PubMed:16043489}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
InterPro domains: - IPR051413: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (family) [45-734]
- IPR014710: RmlC-like jelly roll fold (homologous_superfamily) [420-556]
- IPR013621: Ion transport N-terminal (domain) [50-92]
- IPR000595: Cyclic nucleotide-binding domain (domain) [428-541]
- IPR003938: Potassium channel, voltage-dependent, EAG/ELK/ERG-like (family) [88-514]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [354-544]
- IPR005821: Ion transport domain (domain) [94-356]
Interaction partners: - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
- BTB/POZ domain-containing protein KCTD3
- PEX5-related protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0005267 (potassium channel activity), GO:0046873 (metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0003008 (system process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0098900 (regulation of action potential), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0086065 (cell communication involved in cardiac conduction), GO:0086019 (cell-cell signaling involved in cardiac conduction), GO:0098660 (inorganic ion transmembrane transport), GO:0044057 (regulation of system process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0032970 (regulation of actin filament-based process), GO:0010033 (response to organic substance), GO:0003012 (muscle system process), GO:0003254 (regulation of membrane depolarization), GO:0002027 (regulation of heart rate), GO:0098739 (import across plasma membrane), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0098901 (regulation of cardiac muscle cell action potential), GO:0098655 (monoatomic cation transmembrane transport), GO:0071417 (cellular response to organonitrogen compound), GO:0046683 (response to organophosphorus), GO:0071310 (cellular response to organic substance), GO:0006936 (muscle contraction), GO:0086091 (regulation of heart rate by cardiac conduction), GO:1901699 (cellular response to nitrogen compound), GO:0090257 (regulation of muscle system process), GO:0099587 (inorganic ion import across plasma membrane), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0001508 (action potential), GO:1903115 (regulation of actin filament-based movement), GO:0051899 (membrane depolarization), GO:0051591 (response to cAMP), GO:0098657 (import into cell), GO:0098662 (inorganic cation transmembrane transport), GO:0010243 (response to organonitrogen compound), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0006937 (regulation of muscle contraction), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0098659 (inorganic cation import across plasma membrane), GO:0035725 (sodium ion transmembrane transport), GO:0071320 (cellular response to cAMP), GO:0071407 (cellular response to organic cyclic compound), GO:0086004 (regulation of cardiac muscle cell contraction), GO:0008016 (regulation of heart contraction), GO:0086001 (cardiac muscle cell action potential), GO:0014074 (response to purine-containing compound), GO:0086010 (membrane depolarization during action potential), GO:0055117 (regulation of cardiac muscle contraction), GO:0061337 (cardiac conduction), GO:0098719 (sodium ion import across plasma membrane), GO:0006942 (regulation of striated muscle contraction), GO:0030001 (metal ion transport), GO:1990573 (potassium ion import across plasma membrane), GO:0006813 (potassium ion transport), GO:0006814 (sodium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0016020 (membrane), GO:0048471 (perinuclear region of cytoplasm), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0098797 (plasma membrane protein complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0008076 (voltage-gated potassium channel complex), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)