Protein: Pineapple eye protein (Q9VKW2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Required for survival of imaginal disk cells possibly by regulation of cell apoptosis. Required for germline stem cell self-renewal through mediation of BMP signaling.
Sequence: MEDNKELQCLICKYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAEKRKCWYCNKIGASLQCDRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKRQLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRCIWCRSERFRDSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYNRLSWVILCCSSCAATSAHLKCLVGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSLTQTPVFSEEDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTSIDENHSPQPIARRDTSDSPQPIAASEIPDSPQPTAASEIPDLPQTTAINVNPELTQQTALNTIPHSPQPEASFSTQLVSQTFDCPQPQEQAVAKAPNSPSLPKEDPNTLLVLKSGFQCPGEPFFYLVIYEFEHGTCMGECIGTCVLRFKEDDPRIQDTSQAALERVNITPDDVWCRSEDRGIFEHIEKFHEWYRSEGFS
InterPro domains: - IPR051188: PHD-type Zinc Finger Domain-Containing Protein (family) [5-353]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [202-284]
- IPR034732: Extended PHD (ePHD) domain (domain) [6-119]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [3-289]
- IPR001965: Zinc finger, PHD-type (domain) [73-282]
Interaction partners: - Plexus, isoform A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0005102 (signaling receptor binding), GO:0005112 (Notch binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0019222 (regulation of metabolic process), GO:0008283 (cell population proliferation), GO:0009893 (positive regulation of metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048134 (germ-line cyst formation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0030238 (male sex determination), GO:0018992 (germ-line sex determination), GO:0060255 (regulation of macromolecule metabolic process), GO:0007530 (sex determination), GO:0007538 (primary sex determination), GO:0007283 (spermatogenesis), GO:0010628 (positive regulation of gene expression), GO:0048232 (male gamete generation), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus), GO:0005700 (polytene chromosome), GO:0043073 (germ cell nucleus), GO:0001673 (male germ cell nucleus)