Protein: Actin-2 (EC 3.6.4.-) (P10984)
Organism: Caenorhabditis elegans
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular location: Cytoplasm, cytoskeleton.
Sequence: MCDDDVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITVGNERFRCPEALFQPSFLGMESAGIHETSYNSIMKCDIDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF
InterPro domains: - IPR020902: Actin/actin-like conserved site (conserved_site) [105-117]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [4-376]
- IPR004000: Actin family (family) [4-376]
- IPR004001: Actin, conserved site (conserved_site) [54-365]
Interaction partners: - Actin-related protein 2
- Actin-related protein 3
- Actin-1
- DNA-directed RNA polymerase II subunit RPB1
- Actin-related protein 2/3 complex subunit
- Probable actin-related protein 2/3 complex subunit 4
- Probable actin-related protein 2/3 complex subunit 3
- Probable actin-related protein 2/3 complex subunit 2
- Actin-related protein 10
- Tropomyosin isoforms a/b/d/f
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0051301 (cell division), GO:0007275 (multicellular organism development), GO:0030029 (actin filament-based process), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0000910 (cytokinesis), GO:1903047 (mitotic cell cycle process), GO:0030036 (actin cytoskeleton organization), GO:0000278 (mitotic cell cycle), GO:0030866 (cortical actin cytoskeleton organization), GO:0006996 (organelle organization), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0000281 (mitotic cytokinesis), GO:0009792 (embryo development ending in birth or egg hatching), GO:0007010 (cytoskeleton organization), GO:0030865 (cortical cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030017 (sarcomere), GO:0005737 (cytoplasm), GO:0036379 (myofilament), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043292 (contractile fiber), GO:0098857 (membrane microdomain), GO:0043229 (intracellular organelle), GO:0005865 (striated muscle thin filament), GO:0043228 (non-membrane-bounded organelle), GO:0045121 (membrane raft), GO:0099512 (supramolecular fiber), GO:0030016 (myofibril), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)