Protein: Inositol 5-phosphatase 4 (RhoGAP domain-containing protein) (Q8I7P3)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Not known
Subcellular location: Cytoplasmic vesicle, phagosome membrane {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane {ECO:0000256|ARBA:ARBA00004146}.
Sequence: MGDIQNTDNIESNIDNNNNNNVSLESSSSSQNNNTNTTTTTTTTSVDNLQVGVLSISDQSTPTIETPNQQQQQQQDDNNRGVSNETIKASLDGLKHNSLKTTFPNSTNHQYIDVNTQWITNKLKERESEFTEKRGMSIFLGTWNVNGKKPSESLDPWLKDPSMSLQPDIYAIGFQELDLTAEALLLGDTTRSLPWEQHILNTLQGDYVKLLSKQLVGILLCVYVKKEHKPHIANVQSDIAAVGIMGMMGNKGGVAIRFSFYNTTICILNSHLNAHMDNVLRRNQDMKDISKNIKFINESSTDHSTINIFDHDQLFWIGDLNYRIPLPDNEVKEKIKKKDFYNLFLVDQLNQQMKAGAVFEGFQEPPISFAPTYKYDAGTEEYDSSEKKRTPAWCDRILWKTHKKAENVGILSYKRAELISSDHRPVSASFVIKIKVVIPDSKNRIYQEIVKELDKKENDSMPDANISTNMVDFETIKFMQPISKQLIFENIGQVIARFQFIPKLDETILCKPWLKISPLAGMMIPKEKVTIDLTIYVDNLTSGLFNINNNSTNSTNESMDDILILHLENGKDYFISISGKFQKTCFGNTLDNLVRYPHPIRNNLPIPPEQKKLSIPKELWRIIDYIYYNGLKEEGLFIKSGVTKEMELIRDCLDTAEPFSSISFSIHSMAETLIRFLESLVEPVIPFNMYQQALDASSSPLSCKTLVSHLPSVNYNVFFYLISFLIETLSNQKENDLKPDQLAIIFSTVLLRPSPQSQLSQFPPDATTVKKKADLILHFLISKDLIN
InterPro domains: - IPR047078: Inositol polyphosphate 5-phosphatase OCRL, RhoGAP (domain) [574-782]
- IPR000300: Inositol polyphosphate-related phosphatase (domain) [134-438]
- IPR048869: OCRL-1/2, ASH domain (domain) [466-581]
- IPR046985: Inositol 5-phosphatase (family) [27-731]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [463-595]
- IPR000198: Rho GTPase-activating protein domain (domain) [588-787]
- IPR036691: Endonuclease/exonuclease/phosphatase superfamily (homologous_superfamily) [111-462]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [585-786]
- IPR037793: OCRL1/INPP5B, INPP5c domain (domain) [136-432]
Interaction partners: - Phosphatidylinositol-3-phosphatase SAC1
- Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- Phosphatidylinositol 4-kinase
- Phosphatidylinositol 3-kinase 1
- phosphoinositide 5-phosphatase
- SAC domain-containing protein
- 1-phosphatidylinositol 4-kinase
- 1-phosphatidylinositol 4-kinase
- LIM-domain containing phosphatase
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity), GO:0052866 (phosphatidylinositol phosphate phosphatase activity), GO:0052745 (inositol phosphate phosphatase activity), GO:0046030 (inositol trisphosphate phosphatase activity), GO:0034595 (phosphatidylinositol phosphate 5-phosphatase activity), GO:0034593 (phosphatidylinositol bisphosphate phosphatase activity), GO:0106019 (phosphatidylinositol-4,5-bisphosphate phosphatase activity), GO:0004439 (phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0044085 (cellular component biogenesis), GO:0006629 (lipid metabolic process), GO:0006935 (chemotaxis), GO:0019637 (organophosphate metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0030030 (cell projection organization), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0022607 (cellular component assembly), GO:0006796 (phosphate-containing compound metabolic process), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0006650 (glycerophospholipid metabolic process), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0046847 (filopodium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)