Protein: WD repeat-containing protein 36 (Q8NI36)
Organism: Homo sapiens (Human)
Function: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2
Subcellular location: Nucleus, nucleolus
Sequence: MERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIVHTFKGHKAEIHFLQPFGDHIISVDTDGILIIWHIYSEEEYLQLTFDKSVFKISAILHPSTYLNKILLGSEQGSLQLWNVKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLMSGQVIIHNIKFNETLMKFRQDWGPITSISFRTDGHPVMAAGSPCGHIGLWDLEDKKLINQMRNAHSTAIAGLTFLHREPLLVTNGADNALRIWIFDGPTGEGRLLRFRMGHSAPLTNIRYYGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLINKKRVKRKGLQNTMSVRLPPITKFAAEEARESDWDGIIACHQGKLSCSTWNYQKSTIGAYFLKPKELKKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSFGKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSLSSSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCFLLDSAPLNVSMSPTGDFLATSHVDHLGIYLWSNISLYSVVSLRPLPADYVPSIVMLPGTCQTQDVEVSEETVEPSDELIEYDSPEQLNEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPKSAPFFIPTIPGLVPRYAAPEQNNDPQQSKVVNLGVLAQKSDFCLKLEEGLVNNKYDTALNLLKESGPSGIETELRSLSPDCGGSIEVMQSFLKMIGMMLDRKRDFELAQAYLALFLKLHLKMLPSEPVLLEEITNLSSQVEENWTHLQSLFNQSMCILNYLKSALL
InterPro domains: - IPR059156: WDR36/Utp21, second beta-propeller domain (domain) [327-661]
- IPR059157: WDR36/Utp21, N-terminal domain (domain) [42-307]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [26-635]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [13-637]
- IPR001680: WD40 repeat (repeat) [95-636]
- IPR019775: WD40 repeat, conserved site (conserved_site) [581-595]
- IPR007319: WDR36/Utp21, C-terminal domain (domain) [689-891]
Interaction partners: - U3 small nucleolar RNA-associated protein 15 homolog
- WD repeat-containing protein 75
- U3 small nucleolar RNA-associated protein 4 homolog
- HEAT repeat-containing protein 1
- U3 small nucleolar RNA-associated protein 6 homolog
- Nucleolar protein 56
- DDB1- and CUL4-associated factor 13
- Bystin
- Neuroguidin
- KRR1 small subunit processome component homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0050793 (regulation of developmental process), GO:0071840 (cellular component organization or biogenesis), GO:0065008 (regulation of biological quality), GO:0048871 (multicellular organismal-level homeostasis), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0060249 (anatomical structure homeostasis), GO:0048638 (regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0061387 (regulation of extent of cell growth), GO:0030516 (regulation of axon extension), GO:0032535 (regulation of cellular component size), GO:0001895 (retina homeostasis), GO:0008361 (regulation of cell size)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)