Protein: E3 ubiquitin-protein ligase listerin (Q7S834)
Organism: Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
Function: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non- stop proteins) and other translation arrest products induced by poly- lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription (By similarity)
Subcellular location: Nucleus. Cytoplasm, cytosol
Sequence: MKKGGFGSGGFGAFSSSTASLSYVAPPPDLSSVPQDVIVPFKNLLKRDSTTKSKALEEILACVKKSDQPVDDSVIDVWAQLYPRVAIDNNRRVRELSHNLLLELVKSAKKRIEKTLPKLVGPWVAGTFDKDKGVARAALAVSAHILDSDQKKAKFWIAFQGKLLEYSNEAIRETADSLSDERTTSKEDMEAKYYRVLGSSMAMIQHLLPTVKDDQYPDELKRFFDADTLWTLAASDDASVRRAFYQLVASYLDNKPSLLEPKLKDVGKVLVAEGPKKEQRGSAVDLLRALISVTKRFPKVWGSKSPLDRLRPLVQKGSQGGSDEFWTELDQLLAILPTSSPDYAANAPAFLKSMRTAITSREERRQNAASAWACYLNTVDRITAGSTPSPDFLQENLYPLTREYLHPSTETSTWAYAQPPHVFKAWKIVPYTTNEQVRSSAKEEWQKLGDDFAAGLSNSLPEVSPDYEKSQLELAAQGDRWFTLVQGFLRGAPSQQSFDGDADLPSVVASTSRKLLESAQDLLARRNYKPFCAAAVLKAAFTKAPVLCAKSDLIKKVFPLDDQEAFEKIVVSRSLPFLASCLGAVTPDQPDFSEQVWVKLIDAALSHGFPSGAPIVKELVSVPLPQTVAQKSEALQNFIVEAWQDFFKEEPSSPVVEQLCRASISHSVVDDKTLQSLASSFAQDIGVAGKYDPEFKALDLLLRNKSALFADAPVDLFTRLLSLEEISDSEKATKVAAIRSLIQKQYGGNKLWLEVIRLSLAEADPSSLDINTLIRHAKEILSSGVPLTDLLPSAKAWNTELYSFLRDNPDPSLSITSSFGGAYFLATESEGSTLTTQKRDRQGRSIPARMAIYTTNLFTDVDLESVQADLLELIFLTAVLANDDLTVMKENGLWSLPASEDIRTERSDEIQSFLDLGTSLLARVAGASASWKEGDLDGTSLAEMLIQSLLQQAVDFSAKALYASKALTELFQALVSVHGYPAGAKFDEWFNKLGIMKATPQTVFAAIAFLTGFDEGLASSRAVANLYNRLVSDIVGCFPSSPKTLYNVVLLNICLSVYPPAKTPVEQRKLVFALKQFTTWVQTPDEMTFGLTAEVCKGIHRILPNVAQVYGPYWREAIDYCLLLWEKARNDTPQRWPAYVLPSIRLISSMETLEDPNDDLVEALEETAVDRSKALIRLLELPHDVVNTARQILDETLCRAVQKIPLKHLTSEKDLLTNLYGLLSSGSREVQTAAFGLLHRALPAQQEEEVLETLLEEKVAKVPDELLSIIQAVPELEKYTDEELAGFPVDVRSYLLGWHLVFDAYNQAPLQVRKQYTDSLKADNSLNALLELMFDVLGHSTGQALNLDKNTFSAEHIRSYDVSQSEEGTKERDMQWLLVHLFYLSLKFLPGLVKSWYLDLRSKQTKIALDSWMAKYYAPLLISDALDEVNDWASSQEAPQEDEKELRVRVNRTAKEVSAGYEIDEDFASIAIKIPAGYPLESVEVIGENRVAVNEKKWQSWVRATQGVITFANGSITDGLAAFRRNIIGALKGHTECPICYAVVSADKKLPDKRCSTCNNLFHRLCLYKWFQNSNKNTCPLCRNPIDYLGSSTRRGGGGD
InterPro domains: - IPR001841: Zinc finger, RING-type (domain) [1536-1583]
- IPR016024: Armadillo-type fold (homologous_superfamily) [47-670]
- IPR011989: Armadillo-like helical (homologous_superfamily) [39-294]
- IPR039795: E3 ubiquitin-protein ligase listerin (family) [8-1585]
- IPR039804: Listerin, zinc finger, RING-type (domain) [1535-1583]
- IPR054477: E3 ubiquitin-protein ligase listerin, HEAT repeat region (domain) [1210-1430]
- IPR054478: E3 ubiquitin-protein ligase listerin, ubiquitin conjugating domain (domain) [1446-1527]
- IPR057030: E3 ubiquitin-protein ligase listerin, tetratricopeptide repeats region (domain) [588-745]
- IPR011016: Zinc finger, RING-CH-type (domain) [1536-1583]
- IPR054476: E3 ubiquitin-protein ligase listerin, N-terminal domain (domain) [35-334]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [1524-1593]
Interaction partners: - Ribosome quality control complex subunit 2
- HECT-type E3 ubiquitin transferase
- Nulp1-pending protein
- 60S ribosomal protein L25
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)