Protein: 5'/3'-nucleotidase SurE (P0A840)
Organism: Escherichia coli (strain K12)
Function: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20- 25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of E.coli in stationary growth phase
Subcellular location: Cytoplasm
Sequence: MRILLSNDDGVHAPGIQTLAKALREFADVQVVAPDRNRSGASNSLTLESSLRTFTFENGDIAVQMGTPTDCVYLGVNALMRPRPDIVVSGINAGPNLGDDVIYSGTVAAAMEGRHLGFPALAVSLDGHKHYDTAAAVTCSILRALCKEPLRTGRILNINVPDLPLDQIKGIRVTRCGTRHPADQVIPQQDPRGNTLYWIGPPGGKCDAGPGTDFAAVDEGYVSITPLHVDLTAHSAQDVVSDWLNSVGVGTQW
InterPro domains: - IPR002828: Survival protein SurE-like phosphatase/nucleotidase (domain) [1-232]
- IPR036523: SurE-like phosphatase/nucleotidase superfamily (homologous_superfamily) [1-253]
- IPR030048: Survival protein SurE (family) [1-249]
Interaction partners: - Protein-L-isoaspartate O-methyltransferase
- 5'-deoxynucleotidase YfbR
- Pyrimidine 5'-nucleotidase YjjG
- tRNA pseudouridine synthase D
- Protein UshA
- GMP/IMP nucleotidase YrfG
- Uridylate kinase
- Uridylate kinase
- Uridylate kinase
- Uridylate kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0043167 (ion binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0043169 (cation binding), GO:0042578 (phosphoric ester hydrolase activity), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0046872 (metal ion binding), GO:0016462 (pyrophosphatase activity), GO:0016791 (phosphatase activity), GO:0046914 (transition metal ion binding), GO:0008252 (nucleotidase activity), GO:0030145 (manganese ion binding), GO:0008253 (5'-nucleotidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0005975 (carbohydrate metabolic process), GO:1901575 (organic substance catabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0044275 (cellular carbohydrate catabolic process), GO:0009311 (oligosaccharide metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006643 (membrane lipid metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0044242 (cellular lipid catabolic process), GO:0046434 (organophosphate catabolic process), GO:0046467 (membrane lipid biosynthetic process), GO:0046434 (organophosphate catabolic process), GO:0008610 (lipid biosynthetic process), GO:0016042 (lipid catabolic process), GO:0008654 (phospholipid biosynthetic process), GO:0009312 (oligosaccharide biosynthetic process), GO:0006664 (glycolipid metabolic process), GO:1901271 (lipooligosaccharide biosynthetic process), GO:0046493 (lipid A metabolic process), GO:0009247 (glycolipid biosynthetic process), GO:0009245 (lipid A biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)