Protein: 1-phosphatidylinositol 4-kinase (EC 2.7.1.67) (M9PDM4)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MTMTASDKYTYQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEGQIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQVETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIFPPELLPIQKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGGKPSKPSLHSYFSVPYDPRTHFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMDHMPLLMVCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAVQHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQFHHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQIPY
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [366-1768]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [1781-2149]
- IPR015433: Phosphatidylinositol 3-/4-kinase (family) [630-2152]
- IPR042236: Phosphoinositide 3-kinase, accessory (PIK) domain superfamily (homologous_superfamily) [1611-1778]
- IPR045495: PI4-kinase, N-terminal (domain) [378-1568]
- IPR018936: Phosphatidylinositol 3-/4-kinase, conserved site (conserved_site) [1901-2014]
- IPR036940: Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (homologous_superfamily) [1959-2152]
- IPR000403: Phosphatidylinositol 3-/4-kinase, catalytic domain (domain) [1873-2151]
- IPR001263: Phosphoinositide 3-kinase, accessory (PIK) domain (domain) [1593-1782]
Interaction partners: - Phosphatidylinositol-3-phosphatase SAC1
- Tetratricopeptide repeat domain 7, isoform A
- Phosphatidylinositol 4-kinase type 2
- Phosphatidylinositol 4-phosphate 5-kinase type-1 sktl
- GH21176p
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol 4-phosphate 5-kinase 59B, isoform E
- CDP-diacylglycerol--inositol 3-phosphatidyltransferase
- phosphoinositide 5-phosphatase
- EG:86E4.5 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0016301 (kinase activity), GO:0052742 (phosphatidylinositol kinase activity), GO:0004430 (1-phosphatidylinositol 4-kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0040007 (growth), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0007163 (establishment or maintenance of cell polarity), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0044238 (primary metabolic process), GO:0030029 (actin filament-based process), GO:0048609 (multicellular organismal reproductive process), GO:0040008 (regulation of growth), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1901576 (organic substance biosynthetic process), GO:0030010 (establishment of cell polarity), GO:0007293 (germarium-derived egg chamber formation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0050803 (regulation of synapse structure or activity), GO:0030036 (actin cytoskeleton organization), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0006629 (lipid metabolic process), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0048638 (regulation of developmental growth), GO:0050807 (regulation of synapse organization), GO:0010256 (endomembrane system organization), GO:0006644 (phospholipid metabolic process), GO:1901888 (regulation of cell junction assembly), GO:0048477 (oogenesis), GO:0006796 (phosphate-containing compound metabolic process), GO:0045229 (external encapsulating structure organization), GO:0045017 (glycerolipid biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0043062 (extracellular structure organization), GO:0007292 (female gamete generation), GO:0090407 (organophosphate biosynthetic process), GO:0008582 (regulation of synaptic assembly at neuromuscular junction), GO:0006996 (organelle organization), GO:0008610 (lipid biosynthetic process), GO:0097435 (supramolecular fiber organization), GO:0061024 (membrane organization), GO:0007015 (actin filament organization), GO:0046474 (glycerophospholipid biosynthetic process), GO:1904396 (regulation of neuromuscular junction development), GO:0007010 (cytoskeleton organization), GO:0006650 (glycerophospholipid metabolic process), GO:0051963 (regulation of synapse assembly), GO:0008654 (phospholipid biosynthetic process), GO:0030198 (extracellular matrix organization), GO:0007009 (plasma membrane organization), GO:0071711 (basement membrane organization), GO:0046488 (phosphatidylinositol metabolic process), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0046854 (phosphatidylinositol phosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098793 (presynapse), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0042734 (presynaptic membrane), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)