Protein: [histone H3]-lysine(36) N-trimethyltransferase (F1QJI9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome. Nucleus
Sequence: MDALLNPELREDVKDCSIKVENFPKQVIFKGLAPRVVLTNHLLMKGNKTKVNLEEQGRQKVSFSLTQTKKPRQNVFLPPPSPEKSASEHSSTSQAGPVPVSVQAGQTYETKNVDTNTPAVGETQTAPTVSFSLRSRHVLGKMHFKKQILSSTVVGDKSTVSTASAEISEPVVPSDKITSSAKVETENSLQQSHKNSVVDGSSEKVSKEENPQEKIASCLKGPDSSHIGKEDTDSSIISEHEESRKSKQCSDSKLAGLETDGQSTRTSSSQKSNDRRNKTKSESHSNEVKRSSNSKTELDKSRTDRKDEEKGIRHSKSDRDSRHMSSRSSRSDRDRRRTKSRSRSRSRGSRTSSYSRSERSRSERQSRTDRSHYHESERRFHRSSPHRERRSSRSRTDGRSRDSSDSEDDHRRTRTRGSDSSRSSTYSSSQKDSKSSTHSRSHRDSKPTDCSRSSESDKRAQHSKSESNRRSSSEIDAVHKKSSARTKLEVNDKISNSNLTTSSRTSEKKIHKTSSDSDEEHRRKRQSQGSDRSPRSGTSSSRKNDLVDHNSFNIGTGTERQSTDRLNTNAKDSQLVFVTVTSQKESSNIDDQCTPPKSKNSSQQMHEATHKVNLCETNKKAEHQPSNQDLSSLEKCTNVPESKKTTERLTESISITSGKLEVRSPTEVDEPGMKVTVPIQSEVLTVGQTESICVGPAPSEHTMGSLTDSLSVKELPPEGSLILNTKSDESSLIISQISTPVTLTVQPCEKDSEQNIGSPEQPNTGISKKDASAKKSRWDIVGQVTSEYQSPAKLVNPDVKKVMLAQKIEFSDTTPDNCSQKLDPEVPSEKSVEVHARDTTAAESHQEISSFTSNFGTKGTHDELQKTVEIPQSTSALVVSDFQPSKEKVNVDKTKPEIQDPDSLNHDGKCHSDDSESEESDSDSDDGRVSLKRLHSVVVVPKNSTIALETNDKAEPAPASSLFSGNQQTDTHESINKEFPYGFNNQSTLKESSAALYKGSAQAACQSPNVKGVSYQSQSNMVDSTSHLEVMSAHVDKNWSAQERPNISGQINQEYVQNFEKTCEKPETDHHQYHGRPDSWNGRKGDFSVGRGDSLVWDFNQSEQPSSTFQQPDSSYSTPQPLFDSVHREDPWAQPAISKTSRTVNTHVPFQYHDLVHQIHPDSLTNDHDDDREGRILGIKQASLLSAGLPGPSPFVQAPEISSNCSFTTESQNISEAPRDDNQKPHRGRGPPKKRRQEFESESDNEAEAGLSKRECFDESSRPLKDAKESFHQIQEVQRPLLSLKEFSDPFVWRDKAKQKKMPPYFDLIEENLYLTERKKNKSHRDIKRMQCECAILSKEERARGILACGEDCLNRLLMIECSSRCLNGAYCSNRRFQMKQHADYEVILTESKGWGLRAAKDLQPNTFVLEYCGEVLDHREFKARVKEYARNKNIHYYFMALKNNEIIDATLKGNCSRFMNHSCEPNCETQKWTVNGQLRIGFFTTKAVTAGTELTFDYQFQRYGKEAQKCFCGAPSCRGLIGGETRVSVRAAGGKKQRERSRKKDTDSALTTLDEELEALQENGEGLCGEKEVISLCRLMVRVETMEQRLTCLKLIQNTQNPLCLKQFLDHHGLSLLWIFMVELSEAKTNSVNNIKLQLEIMKALSVLPISTKNMLEESRVLQFIQRWAQSRSLSQPAEQDGYSSESTSRAQTPLNTPDGPPAKLATELDGDTPKRAVYRRLKIISENSLDSALSDASKASDGKEEEDEEEEEMEDEPSKLESTTERKIKVESTEAPPVSQAELEVELKQEAPETVEIPRLMPEAVGSEGETLETQEPEEKLLCTPEGQLKDEKTVEETKSDEPSENQTESAAVKEDPLVTDTTSAADISNDVVADAETPVTETQVENASSEQSTSEEDASCSTAEITSAQPAEVIIEGISSDSAAIVIKSTPKESPSVSVKTPPTGSDVVSNGNAPSEAVFAPSEAVAAPLEAAVAPSEAVASFPEAVASLPETVAAPAEAVDEPAEAVADPAEAVADPAEAVADPAEAVAEPAEAVAAPAEAVAAPPEAVAAPPEAVAAPVSADVSALAIVPVPAEGAAVGTPSQDEEEGVSDVESERSQEPQIRASDISDMAARLLDSWKDLKEVYRIPKKSQVEKESNDRSRDRESLMTPRTSSSSRERERERDKERDRDRDRDWEREREWDRDRERDRDGERPTLRSADRKRRRGSTSPLPPPAYERSRRNDDRYELSSSSKKKLHTKEARTKLSTEERRKLFEQEVAQREAQKQQQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLQTLAFNPLAYTSSPNFMNYPPGYPIQTYVDPTNPNAGKVLLPTPPVEPICVTPAAGTFEQPPALDLGIASPSSTTTQAGPASSLAHIPAPLELSSGTQTQFVQPAVPAQDPSVAVLSVPAQAASPQIPSQQGYTTLWDPNTQQAVTVQTQPTQQYSTTSQPQAAIYYQGQPCQTIYSIPAGYPQTNPPVIQAYTEPAANYLHSQQVYTQGGTVTTIVTSQPVQQEMIVPNNIIDLPPPSPPKPKTIILPPSWKVARDPEGRIYYYHIITRQTQWDPPSWDGTTEEASVEHEAEMDLGTPTYDENPSKFSTKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKLGRISNTEDFKHLARKLTHGVMNKELKSCKNPEDLECNENVKHKTKEYIKKYMQKFGSVYRPKEDTELD
InterPro domains: - IPR036020: WW domain superfamily (homologous_superfamily) [2557-2596]
- IPR044437: SETD2/Set2, SET domain (domain) [1382-1523]
- IPR046341: SET domain superfamily (homologous_superfamily) [1271-1544]
- IPR013257: Set2 Rpb1 interacting domain (domain) [2648-2729]
- IPR038190: Set2 Rpb1 interacting domain superfamily (homologous_superfamily) [2626-2737]
- IPR001202: WW domain (domain) [2564-2597]
- IPR003616: Post-SET domain (domain) [1507-1523]
- IPR042294: Histone-lysine N-methyltransferase SETD2, animal (family) [175-2736]
- IPR006560: AWS domain (domain) [1327-1382]
- IPR001214: SET domain (domain) [1383-1506]
Interaction partners: - DNA-directed RNA polymerase subunit
- Histone H3
- Histone H3.2
- DNA-directed RNA polymerase II subunit RPB3
- Transcription elongation factor SPT6
- Ash1 (absent, small, or homeotic)-like (Drosophila)
- Histone-lysine N-methyltransferase KMT5B
- Protein polybromo-1
- Histone-lysine N-methyltransferase, H3 lysine-79 specific
- Histone H3.3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0046975 (histone H3K36 methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0019538 (protein metabolic process), GO:0009790 (embryo development), GO:0043414 (macromolecule methylation), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0007369 (gastrulation), GO:0060027 (convergent extension involved in gastrulation), GO:0008213 (protein alkylation), GO:0018022 (peptidyl-lysine methylation), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0034968 (histone lysine methylation), GO:0018205 (peptidyl-lysine modification), GO:0051568 (histone H3-K4 methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)