Protein: RNA polymerase I-specific transcription initiation factor rrn3 (Q10110)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Required for efficient transcription initiation by RNA polymerase I.
Subcellular location: Nucleus {ECO:0000250}.
Sequence: MPSIISSTNPQYINKCVNNGTMASSTNVPDRTVGSKSFASSVSKNDGRLMQQMLRAFVNKALDDKAEGNFAGYEDLRRQFAAKSDTKDAPSSLQLQNLLSALTCNVSRLDSSNSSLVMSVLDSVWVSRDESFVRCYTRFLGNLISAQSNYLPLVMTMLIQHMLYRPDSLAIHYEHAHMALKYVLELVPRAHSFLYSSILEEFPYKDESLLAQMTYISNVLSICEYVPSIKGPVLHAIIDKIIQIDVEIQVEVDDDDEEEDEVVTDDDGTSNADSEVITASTLYERHTAISSEMTSSTILTPPSLTDTRQLMQQLDQLLYTLFSYLDSNLKSTSRDRYLVYNSLIKSFVNTVLKTFRCRYTQFLIFWASQLDPEFTDIFLGVLTEVCLDPSQPYTLRLSGAMYIGSYVARAKALEKNTIQIIVNMMTRWVEAYLDQCENELSDDLLSKHSVFYAINQSIFYIFCFRWRELCVSDESESMEPRPNEWIPGLEILHRSVLSRLNPLRYCSPNIVLQFAKVANHLNFMYVYSIIEQNRKGIFREGFDTMDAYFPFDPYRLTKSSIIVQPFYNEWQQIPGLDDDEEEEDTDYESSTVMLGESPF
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [129-585]
- IPR007991: RNA polymerase I specific transcription initiation factor RRN3 (family) [41-586]
Interaction partners: - DNA-directed RNA polymerase I subunit rpa43
- DNA-directed RNA polymerase I subunit rpa49
- Probable DNA-directed RNA polymerase I subunit RPA2
- DNA-directed RNA polymerase I subunit rpa1
- Uncharacterized protein C3B8.11
- DNA-directed RNA polymerases I and III subunit RPAC1
- DNA-directed RNA polymerase I subunit RPA12
- RNA polymerase I-specific transcription initiation factor rrn11
- DNA-directed RNA polymerases I and III subunit RPAC2
- TATA-box-binding protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0010467 (gene expression), GO:0018130 (heterocycle biosynthetic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process), GO:0097659 (nucleic acid-templated transcription), GO:0006351 (DNA-templated transcription), GO:0006352 (DNA-templated transcription initiation), GO:0006360 (transcription by RNA polymerase I), GO:0006361 (transcription initiation at RNA polymerase I promoter)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)