Protein: Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain] (P06399)
Organism: Rattus norvegicus (Rat)
Function: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Subcellular location: Secreted {ECO:0000250|UniProtKB:P02671}.
Sequence: MLSLRVACLILSLASTVWTADTGTTSEFIEAGGDIRGPRIVERQPSQCKETDWPFCSDEDWNHKCPSGCRMKGLIDEANQDFTNRINKLKNSLFDFQKNNKDSNSLTRNIMEYLRGDFANANNFDNTFGQVSEDLRRRIQILKRKVIEKAQQIQVLQKDVRDQLIDMKRLEVDIDIKIRSCKGSCSRSVSREINLKDYEGQQKQLEQVIAKDLLPAKDRQYLPAIKMSPVPDLVPGSFKSQLQEGPPEWKALTEMRQMRMELERPGKDGASRGDLPGDSRGDSATRGPGSKIENPMTPGHGGSGYWRPGSSGSGSDGNWGSGTTGSDDTGTWGAGSSRPSSGSGNLKPSNPDWGEFSEFGGSSSPATRKEYHTGKLVTSKGDKELLIGNEKVTSTGTSTTRRSCSKTITKTVLGNDGHREVVKEVVTSDDGSDCGDGMDLGLTHSFSGRLDELSRMHPELGSFYDSRFGSLTSNFKEFGSKTSDSDIFTDIENPSSHVPEFSSSSKTSTVRKQVTKSYKMADEAASEAHQEGDTRTTKRGRARTMRDCDDVLQTHPSGAQNGIFSIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDKGEGEFWLGNDYLHLLTLRGSVLRVELEDWAGKEAYAEYHFRVGSEAEGYALQVSSYQGTAGDALMEGSVEEGTEYTSHSNMQFSTFDRDADQWEENCAEVYGGGWWYNSCQAANLNGIYYPGGTYDPRNNSPYEIENGVLWVPFRGADYSLWAVRMKIRPLVGQ
InterPro domains: - IPR020837: Fibrinogen, conserved site (conserved_site) [723-735]
- IPR012290: Fibrinogen, alpha/beta/gamma chain, coiled coil domain (domain) [49-193]
- IPR021996: Fibrinogen alpha C domain (domain) [388-452]
- IPR037579: Fibrinogen/angiopoietin-like (family) [1-780]
- IPR014716: Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 (homologous_superfamily) [525-692]
- IPR002181: Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain (domain) [539-780]
- IPR036056: Fibrinogen-like, C-terminal (homologous_superfamily) [543-779]
Interaction partners: - Prothrombin
- Fibrinogen gamma chain
- Fibrinogen beta chain
- Plasminogen
- Albumin
- Antithrombin-III
- Alpha-2-HS-glycoprotein
- Coagulation factor XIII B chain
- Serpin family F member 2
- Protein AMBP
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0050817 (coagulation), GO:0065008 (regulation of biological quality), GO:0006950 (response to stress), GO:0009611 (response to wounding), GO:0050878 (regulation of body fluid levels), GO:0007596 (blood coagulation), GO:0042060 (wound healing), GO:0007599 (hemostasis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0072562 (blood microparticle), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0030312 (external encapsulating structure), GO:0030141 (secretory granule), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0031012 (extracellular matrix), GO:0043025 (neuronal cell body), GO:0005794 (Golgi apparatus), GO:0005783 (endoplasmic reticulum), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus)