Protein: 2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta) (Q9SAV3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250|UniProtKB:P21953}.
Sequence: MAALLGRSCRKLSFPSLSHGARRVSTETGKPLNLYSAINQALHIALDTDPRSYVFGEDVGFGGVFRCTTGLAERFGKNRVFNTPLCEQGIVGFGIGLAAMGNRAIVEIQFADYIYPAFDQIVNEAAKFRYRSGNQFNCGGLTIRAPYGAVGHGGHYHSQSPEAFFCHVPGIKVVIPRSPREAKGLLLSCIRDPNPVVFFEPKWLYRQAVEEVPEHDYMIPLSEAEVIREGNDITLVGWGAQLTVMEQACLDAEKEGISCELIDLKTLLPWDKETVEASVKKTGRLLISHEAPVTGGFGAEISATILERCFLKLEAPVSRVCGLDTPFPLVFEPFYMPTKNKILDAIKSTVNY
InterPro domains: - IPR005475: Transketolase-like, pyrimidine-binding domain (domain) [32-207]
- IPR009014: Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II (homologous_superfamily) [216-352]
- IPR029061: Thiamin diphosphate-binding fold (homologous_superfamily) [29-232]
- IPR033248: Transketolase, C-terminal domain (domain) [223-342]
Interaction partners: - 2-oxoisovalerate dehydrogenase subunit alpha 2, mitochondrial
- 2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial
- Putative 2-dehydropantoate 2-reductase
- Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
- Dihydrolipoyl dehydrogenase 2, mitochondrial
- Dihydrolipoyl dehydrogenase 1, mitochondrial
- Dihydrolipoyl dehydrogenase 1, chloroplastic
- Dihydrolipoyl dehydrogenase 2, chloroplastic
- Pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic
- Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0009991 (response to extracellular stimulus), GO:1901564 (organonitrogen compound metabolic process), GO:0044282 (small molecule catabolic process), GO:0042594 (response to starvation), GO:0009314 (response to radiation), GO:0033554 (cellular response to stress), GO:0006082 (organic acid metabolic process), GO:0044248 (cellular catabolic process), GO:1901700 (response to oxygen-containing compound), GO:0031668 (cellular response to extracellular stimulus), GO:0006520 (amino acid metabolic process), GO:1901575 (organic substance catabolic process), GO:0071496 (cellular response to external stimulus), GO:0010033 (response to organic substance), GO:0009743 (response to carbohydrate), GO:0009416 (response to light stimulus), GO:0016054 (organic acid catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0009267 (cellular response to starvation), GO:0043436 (oxoacid metabolic process), GO:0031667 (response to nutrient levels), GO:0009063 (amino acid catabolic process), GO:0009081 (branched-chain amino acid metabolic process), GO:0031669 (cellular response to nutrient levels), GO:0019752 (carboxylic acid metabolic process), GO:0046395 (carboxylic acid catabolic process), GO:0034285 (response to disaccharide), GO:0009642 (response to light intensity), GO:0009083 (branched-chain amino acid catabolic process), GO:0009646 (response to absence of light), GO:0009744 (response to sucrose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005773 (vacuole), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0000325 (plant-type vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)