Protein: Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110) (Q9HB58)
Organism: Homo sapiens (Human)
Function: Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00185, ECO:0000255|PROSITE-ProRule:PRU00747, ECO:0000269|PubMed:10913195, ECO:0000269|PubMed:25593309}. Note=Found in the nuclear body. {ECO:0000269|PubMed:10913195}.
Sequence: MFTMTRAMEEALFQHFMHQKLGIAYAIHKPFPFFEGLLDNSIITKRMYMESLEACRNLIPVSRVVHNILTQLERTFNLSLLVTLFSQINLREYPNLVTIYRSFKRVGASYEWQSRDTPILLEAPTGLAEGSSLHTPLALPPPQPPQPSCSPCAPRVSEPGTSSQQSDEILSESPSPSDPVLPLPALIQEGRSTSVTNDKLTSKMNAEEDSEEMPSLLTSTVQVASDNLIPQIRDKEDPQEMPHSPLGSMPEIRDNSPEPNDPEEPQEVSSTPSDKKGKKRKRCIWSTPKRRHKKKSLPGGTASSRHGIQKKLKRVDQVPQKKDDSTCNSTVETRAQKARTECARKSRSEEIIDGTSEMNEGKRSQKTPSTPRRVTQGAASPGHGIQEKLQVVDKVTQRKDDSTWNSEVMMRVQKARTKCARKSRLKEKKKEKDICSSSKRRFQKNIHRRGKPKSDTVDFHCSKLPVTCGEAKGILYKKKMKHGSSVKCIRNEDGTWLTPNEFEVEGKGRNAKNWKRNIRCEGMTLGELLKRKNSDECEVCCQGGQLLCCGTCPRVFHEDCHIPPVEAKRMLWSCTFCRMKRSSGSQQCHHVSKTLERQMQPQDQLIRDYGEPFQEAMWLDLVKERLITEMYTVAWFVRDMRLMFRNHKTFYKASDFGQVGLDLEAEFEKDLKDVLGFHEANDGGFWTLP
InterPro domains: - IPR000770: SAND domain (domain) [454-535]
- IPR004865: HSR domain (domain) [1-108]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [533-583]
- IPR019787: Zinc finger, PHD-finger (domain) [534-580]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [534-579]
- IPR043563: Nuclear body protein Sp110/Sp140/Sp140L-like (family) [376-679]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [537-577]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [580-681]
- IPR010919: SAND-like domain superfamily (homologous_superfamily) [448-544]
- IPR001965: Zinc finger, PHD-type (domain) [536-578]
- IPR001487: Bromodomain (domain) [581-676]
Interaction partners: - Nuclear autoantigen Sp-100
- XIAP-associated factor 1
- Antiviral innate immune response receptor RIG-I
- Interferon-induced 35 kDa protein
- Sterile alpha motif domain-containing protein 9-like
- Protein mono-ADP-ribosyltransferase PARP9
- 2'-5'-oligoadenylate synthase 1
- Interferon-induced protein with tetratricopeptide repeats 3
- 2'-5'-oligoadenylate synthase 2
- Signal transducer and activator of transcription 1-alpha/beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0019222 (regulation of metabolic process), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0050776 (regulation of immune response), GO:0001817 (regulation of cytokine production), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0031347 (regulation of defense response), GO:0010628 (positive regulation of gene expression), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0032757 (positive regulation of interleukin-8 production), GO:0010468 (regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)