Protein: Peripheral myelin protein 22 (PMP-22) (Protein CD25) (SR13 myelin protein) (Schwann cell membrane glycoprotein) (SAG) (P25094)
Organism: Rattus norvegicus (Rat)
Function: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Subcellular location: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Sequence: MLLLLLGILFLHIAVLVLLFVSTIVSQWLVGNGHRTDLWQNCTTSALGAVQHCYSSSVSEWLQSVQATMILSVIFSVLSLFLFFCQLFTLTKGGRFYITGVFQILAGLCVMSAAAIYTVRHSEWHVNNDYSYGFAYILAWVAFPLALLSGIIYVILRKRE
InterPro domains: - IPR003936: Peripheral myelin protein PMP22 (family) [44-130]
- IPR004032: PMP-22/EMP/MP20 (family) [18-141]
- IPR050579: Peripheral myelin protein 22/Epithelial membrane protein-like (family) [6-159]
- IPR004031: PMP-22/EMP/MP20/Claudin (family) [1-153]
Interaction partners: - Myelin proteolipid protein
- Laminin subunit beta-2
- Laminin subunit alpha-5
- Tyrosine-protein kinase Lyn
- Laminin subunit beta-1
- Laminin subunit gamma-1
- Integrin beta-4
- Integrin beta-1
- Integrin alpha-7
- Integrin beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0006952 (defense response), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0051668 (localization within membrane), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0045087 (innate immune response), GO:0045184 (establishment of protein localization), GO:0098542 (defense response to other organism), GO:0010035 (response to inorganic substance), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0034097 (response to cytokine), GO:0030030 (cell projection organization), GO:0071705 (nitrogen compound transport), GO:1901654 (response to ketone), GO:0071310 (cellular response to organic substance), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:0022607 (cellular component assembly), GO:0043434 (response to peptide hormone), GO:0072657 (protein localization to membrane), GO:0010243 (response to organonitrogen compound), GO:0015031 (protein transport), GO:0034341 (response to type II interferon), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:1901701 (cellular response to oxygen-containing compound), GO:0061024 (membrane organization), GO:0071375 (cellular response to peptide hormone stimulus), GO:0065003 (protein-containing complex assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:1990778 (protein localization to cell periphery), GO:0071345 (cellular response to cytokine stimulus), GO:0071248 (cellular response to metal ion), GO:0006605 (protein targeting), GO:0031175 (neuron projection development), GO:0034612 (response to tumor necrosis factor), GO:0071346 (cellular response to type II interferon), GO:0043113 (receptor clustering), GO:0071346 (cellular response to type II interferon), GO:0051716 (cellular response to stimulus), GO:0051259 (protein complex oligomerization), GO:0071356 (cellular response to tumor necrosis factor), GO:0051260 (protein homooligomerization), GO:0051291 (protein heterooligomerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)