Protein: Dynamin-A (Q94464)
Organism: Dictyostelium discoideum (Social amoeba)
Function: Function in membrane trafficking processes along the endo-lysosomal pathway.
Subcellular location: Cytoplasm {ECO:0000269|PubMed:9880338}. Note=Found in association with endosomal and postlysosomal vacuoles.
Sequence: MDQLIPVINKLQDVFNTLGSDPLDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLTHLPIADDGSQTQEWGEFLHKPNDMFYDFSEIREEIIRDTDRMTGKNKGISAQPINLKIYSPHVVNLTLVDLPGITKVPVGDQPTDIEQQIRRMVMAYIKKQNAIIVAVTPANTDLANSDALQLAKEVDPEGKRTIGVITKLDLMDKGTDAMEVLTGRVIPLTLGFIGVINRSQEDIIAKKSIRESLKSEILYFKNHPIYKSIANRSGTAYLSKTLNKLLMFHIRDTLPDLKVKVSKMLSDVQGELSTYGDPLYDTKNSQGALLLQIITIFSSNFKDAIDGKLTDLSNNELYGGARISYIFNEIYSHCVNNIDPLEGISLNDIRTTMRNATGPRAALFIPEISFELLVKKQVVRLEEPSAQCVEYVYDELQRIVSQLEAKELSRFINLKARVIEVVNNLLQKHKVPTKTMIEHLIKIETAFINTSHPDFVGGEGIFESLYKKQQLQQQNHLQQLQDQYQQQQQQQQQQQQQNGINNNQKGDNGNMNVNQQNMNQQNMNQQNQSTNPFLQQQQQGQNKYPGGPPAQQQPNQQPNQLNKGPQNMPPNQSKPSSIPQNGPNNNNNNNNNNNRQDHQQGSFFSSFFRASPDPSLGQYGGANNSNNSNNPTSPINSSSNSGNNYNTFGGQQSSSSSSQQLQQSSQSQYKTSYNNNNNSSSNNSSYNRYQDDFYGRGDKLNQVPSIIKAPDDLTSKEKFETELIRELLISYFNIVKKNVKDSVPKSIMHFLVNQSKEHIQNELVAALYKEELFDELLEESPQISSKRKSCKAMIEILRKANEIINEIRDFRN
InterPro domains: - IPR030381: Dynamin-type guanine nucleotide-binding (G) domain (domain) [22-296]
- IPR000375: Dynamin stalk domain (domain) [217-501]
- IPR020850: GTPase effector domain (domain) [762-853]
- IPR022812: Dynamin (family) [3-847]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-305]
- IPR045063: Dynamin, N-terminal (domain) [28-209]
- IPR001401: Dynamin, GTPase domain (domain) [1-296]
- IPR019762: Dynamin, GTPase region, conserved site (conserved_site) [51-60]
- IPR003130: Dynamin GTPase effector (domain) [757-848]
Interaction partners: - Rac guanine nucleotide exchange factor B
- Uncharacterized protein
- Dynamin-like protein B
- Endoplasmic reticulum transmembrane protein YET-like
- Mitochondrial division protein fszB
- Mitochondrial division protein fszA
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0030276 (clathrin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0051640 (organelle localization), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0007155 (cell adhesion), GO:0009607 (response to biotic stimulus), GO:0051707 (response to other organism), GO:0006970 (response to osmotic stress), GO:0104004 (cellular response to environmental stimulus), GO:0043207 (response to external biotic stimulus), GO:0098609 (cell-cell adhesion), GO:0070887 (cellular response to chemical stimulus), GO:0031589 (cell-substrate adhesion), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0009617 (response to bacterium), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0062197 (cellular response to chemical stress), GO:0006971 (hypotonic response), GO:0071470 (cellular response to osmotic stress), GO:0071476 (cellular hypotonic response), GO:0006909 (phagocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0019867 (outer membrane), GO:0043228 (non-membrane-bounded organelle), GO:0005773 (vacuole), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030139 (endocytic vesicle), GO:0005740 (mitochondrial envelope), GO:0043231 (intracellular membrane-bounded organelle), GO:0000331 (contractile vacuole), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031968 (organelle outer membrane), GO:0031982 (vesicle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane), GO:0097708 (intracellular vesicle), GO:0045335 (phagocytic vesicle), GO:0062159 (contractile vacuole complex)