Protein: Protein BIM1 (P40013)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds microtubules.
Subcellular location: Cytoplasm, cytoskeleton.
Sequence: MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYGDLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKKHWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATRHSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFNKLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEMNDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIIDEETF
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [1-124]
- IPR004953: EB1, C-terminal (domain) [188-281]
- IPR027328: Microtubule-associated protein RP/EB (family) [7-288]
- IPR036133: EB1, C-terminal domain superfamily (homologous_superfamily) [198-280]
- IPR001715: Calponin homology domain (domain) [6-107]
Interaction partners: - Karyogamy protein KAR9
- Protein STU2
- Nuclear fusion protein BIK1
- Tubulin alpha-1 chain
- Tubulin beta chain
- Kinesin-like protein KAR3
- Tubulin alpha-3 chain
- Kinesin-like protein KIP2
- Kinesin-like protein KIP3
- Aurora kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0015631 (tubulin binding), GO:0008017 (microtubule binding), GO:0051010 (microtubule plus-end binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0051640 (organelle localization), GO:0007163 (establishment or maintenance of cell polarity), GO:0022402 (cell cycle process), GO:0050794 (regulation of cellular process), GO:0007049 (cell cycle), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0007017 (microtubule-based process), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0051726 (regulation of cell cycle), GO:0007059 (chromosome segregation), GO:1903047 (mitotic cell cycle process), GO:0030010 (establishment of cell polarity), GO:0051653 (spindle localization), GO:0051656 (establishment of organelle localization), GO:0007051 (spindle organization), GO:0050000 (chromosome localization), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0051130 (positive regulation of cellular component organization), GO:0000226 (microtubule cytoskeleton organization), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0045787 (positive regulation of cell cycle), GO:1902850 (microtubule cytoskeleton organization involved in mitosis), GO:1902903 (regulation of supramolecular fiber organization), GO:0098813 (nuclear chromosome segregation), GO:0070507 (regulation of microtubule cytoskeleton organization), GO:0051293 (establishment of spindle localization), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0043244 (regulation of protein-containing complex disassembly), GO:0007097 (nuclear migration), GO:0033043 (regulation of organelle organization), GO:0043243 (positive regulation of protein-containing complex disassembly), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0099111 (microtubule-based transport), GO:0072384 (organelle transport along microtubule), GO:0007010 (cytoskeleton organization), GO:0051493 (regulation of cytoskeleton organization), GO:0040001 (establishment of mitotic spindle localization), GO:0000819 (sister chromatid segregation), GO:0031110 (regulation of microtubule polymerization or depolymerization), GO:0032271 (regulation of protein polymerization), GO:0031113 (regulation of microtubule polymerization), GO:0048285 (organelle fission), GO:0051276 (chromosome organization), GO:0051495 (positive regulation of cytoskeleton organization), GO:0000280 (nuclear division)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:1990752 (microtubule end), GO:0042995 (cell projection), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0099080 (supramolecular complex), GO:0098687 (chromosomal region), GO:0005737 (cytoplasm), GO:0035371 (microtubule plus-end), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043332 (mating projection tip), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0000776 (kinetochore), GO:0005816 (spindle pole body), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0099081 (supramolecular polymer), GO:0000779 (condensed chromosome, centromeric region), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005937 (mating projection), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0005819 (spindle), GO:0005694 (chromosome), GO:0005874 (microtubule), GO:0015630 (microtubule cytoskeleton), GO:0000793 (condensed chromosome), GO:0005876 (spindle microtubule)