Protein: Nucleotide excision repair protein (Q4U2H8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MSIDCQELLRLFGIPYIVAPMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFRAEQIEQTFNCNRGKLIQLACLVGSDYTTGIHGIGAVTALEILASFSGQDANGPGICNQSVLQTLIKFRDWWQAHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYLAPTIDDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAKSALRVQQPHVSKRVQLAIDKMSGKIDETPEKPKKVTRTRRAKAAPPTDDDLAIADVATKAARPKRGKRKAAPESVVLDGELPSTSQSIPKPEKCPRIPSSVEVIPQREKDLEQMRLNKAKAAEILKNSAKANRK
InterPro domains: - IPR006086: XPG-I domain (domain) [10-94]
- IPR019974: XPG conserved site (conserved_site) [13-27]
- IPR008918: Helix-hairpin-helix motif, class 2 (conserved_site) [81-114]
- IPR006084: XPG/Rad2 endonuclease (family) [9-99]
- IPR029060: PIN-like domain superfamily (homologous_superfamily) [4-94]
- IPR036279: 5'-3' exonuclease, C-terminal domain superfamily (homologous_superfamily) [80-242]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0140097 (catalytic activity, acting on DNA), GO:0004518 (nuclease activity), GO:0004536 (deoxyribonuclease activity), GO:0004520 (DNA endonuclease activity), GO:0004519 (endonuclease activity), GO:0016894 (endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters), GO:0016889 (DNA endonuclease activity, producing 3'-phosphomonoesters), GO:0008821 (crossover junction DNA endonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0008219 (cell death), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0051726 (regulation of cell cycle), GO:0012501 (programmed cell death), GO:1901360 (organic cyclic compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0035556 (intracellular signal transduction), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0097190 (apoptotic signaling pathway), GO:0045786 (negative regulation of cell cycle), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0010948 (negative regulation of cell cycle process), GO:0010564 (regulation of cell cycle process), GO:0043170 (macromolecule metabolic process), GO:1901343 (negative regulation of vasculature development), GO:0007346 (regulation of mitotic cell cycle), GO:0000075 (cell cycle checkpoint signaling), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0042770 (signal transduction in response to DNA damage), GO:1901987 (regulation of cell cycle phase transition), GO:0006915 (apoptotic process), GO:0006259 (DNA metabolic process), GO:0097193 (intrinsic apoptotic signaling pathway), GO:1901988 (negative regulation of cell cycle phase transition), GO:0031570 (DNA integrity checkpoint signaling), GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0000077 (DNA damage checkpoint signaling), GO:0000725 (recombinational repair), GO:0006302 (double-strand break repair), GO:0000724 (double-strand break repair via homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)