Protein: FRAS1-related extracellular matrix protein 3 (NV domain-containing protein 2) (Q5H8B9)
Organism: Mus musculus (Mouse)
Function: Extracellular matrix protein which may play a role in cell adhesion.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Sequence: MAGDSLSLPGMSLQLLVTLTCLLLTCALRERVPLSENVSHCELYLPPWGALNGGSHQNPGILIANSGFQVPQGRSVWLNPLRDLVIRVQRGDQCKVTVLDFPRLQGALSPHQFPCDFGAQQVKYTHFGSPSSTRTRIQLQVRYDAGNSTLVLPFTLQVNVVFPKLQLVARNRPLKVFKVLGCSHAIDRRVLNFASRSRCRLTVLPHPGGPLPKYGLLVDTAGNPLSRGHLADCEAFIQAGVRYQHTTTPSSPSRDYVPMLVELLGPESQGTRSVEVLAQEYFQIQVRIQKRARSTAPIPSLAALMIVEVEQSLLTALTPDVLAAEDSESDPDDLVFNILNVPEAPPGHHGGQGYVVNTDDPLGLPVSFFTQKELRELKIAYRPPTGSSEGDHVFQLKLQVVDEDGDTSEPFAFMVVVKSMNVLAPIASYRGGLVVFEGQARPLSDALSFQVSDKDNSKEIKIVAVRGLQHGQLVVHGAPAGCKNFTLADLSAGRVVYQHDGSDSYSDNIILKMEGEHHRVDFLFPITIVPVDDAAPVLTANMGLSVTEGQVVQISPFVLCATDIDSEDSAILFVLEDEHLEGKEEETHEDLAPGSYSSSQHPGNMLLRQAEPPSSLLYSDWHYVEKEGLYETVVTEWLQRDIMEGRLFFSHPGPHSPSPVAHLAFHVQDDQDPPNLSNQHFFTISIQPADTSQPQLSPETTLEMTVQGYQLTPFQQKYLQYTDQNSDEQNLWYTLLTRPTDADSNHQVQAGEIVLTDSPGRPIVHFTQTQVNHQKIAYRPPQRNLGIVPRVVQFTYKVEDTAGNSVSGTFTVFLQPLNNQPPKVINRGFAVLEGDSFILGRGELNVSDPDTNDDQIFFILVWGPQHGHLQYFKKYMVPGESFMLADVINGSISYQNSRDQTDSDVIYLEVSDGVHHIPITVQVSVQPTVADRSPGISITGTPVLATSLTVLENAASEITMDVTHGRKNTNDLMLSFIVEDKPKLGMILVNGWPAEQVTQEDLLGGAVSYVHTSGEIGFQRVHDTFSFILSKDAYHRAMRDNILERVLVEVTVLPVDNMAPKVLVRKPFIVYEGGKNLLTPQHVNIEDVDTSKDEILCTLTVQPSSGYLENLAPAPGSEVSRAGNPISAFFVKDVRVGCINYVQSIHKGIEPGADQFTFYCSDGINFSPKVLLPLTILPTNDEQPQLFTREFVVLEGMSRVIDTSLVNGVDADFPSDKHFRLTVFPQHGQITQQLATGSKPIHSFTLQEIQEPSSIAYEHDDSESTEDSFEVWLSDGRHTTHTTVPIAVILVDDEVPQLTINDGLEIETGHSEIITNHILKAIDLDSDNKSLSFVLHSEPQQGLLQRLRKPGGDAKHNLTVGMNFTQDEIDRGLIHYIHTGQGEAVDLKFDVTDGVNTLRDRYFYITIDNSNSAVPEIVSKRVTLTEGNRMTLTTELLNTSDIHSPGEQLLYSITRAPSTGHLESSDQPGEPMASFTQLQLARNKISYVHISNDKIKLDHFELRVTGGHHSESRIFRIFVTEQDNKKPTLTIQALALQRGDNIVVTPSQLTVEDEDTPADFILFTITQIPIHGRILYNGSRPVTTFTKKDLTKSLIYCHDGSETSKDSFSFTVTDGIHTGFYVFPDTSLETHVPQTVWIQISPFDDRLPQMGINRGATALKLLHTGHLGFLITNEYLQATHQGVPHRLLTYKVTRGPEHGYIVNAGLGNENTHMFTQADIDEMRVYYILNKGRGRATRDTFYFSVETRGGKQLRNQPFHLNWAWISLEKEYYIVDEDSPFFEVTLRRGYLGGTSVVSIGTKGDTAEENKDFKGKAPMLVQFSPGQSTATWRVGLIPDTKYETSETFQIILSEPGAAALEFPEMATVEIVDPEDESTVYIPEAEYQLAEAVGEFLVPVRRSGDTSQELTVICSTRPGSATGTIPSVQLSLSDYVSRPEDNTSMLHFEKDESEKTCQVLIINDSLYEEEESFSIALSLPTGGQLGAKFPTARVTILADREDEPALHFECSEYHAEESAGYVEVAVWRRGTGLSQASSVIVRSRGTEEQAAEAGTDYIGVRQHLHFSPGVSVQRLRVTILDDLPQPAFEGPEMFELLLQMPTGAVIGEPNKTTVTINDSVTNCEECV
InterPro domains: - IPR038081: CalX-like domain superfamily (homologous_superfamily) [1750-2115]
- IPR039005: CSPG repeat (repeat) [298-1745]
- IPR003644: Na-Ca exchanger/integrin-beta4 (domain) [1752-2115]
- IPR045658: FRAS1-related extracellular matrix protein, N-terminal domain (domain) [61-261]
- IPR051561: FRAS1-related extracellular matrix (family) [22-2120]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0048736 (appendage development), GO:0035107 (appendage morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048839 (inner ear development), GO:0048513 (animal organ development), GO:0009888 (tissue development), GO:0048731 (system development), GO:0072001 (renal system development), GO:0060173 (limb development), GO:0035113 (embryonic appendage morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0042733 (embryonic digit morphogenesis), GO:0035108 (limb morphogenesis), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0048880 (sensory system development), GO:0072359 (circulatory system development), GO:0007507 (heart development), GO:0007423 (sensory organ development), GO:0043583 (ear development), GO:0030326 (embryonic limb morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0005615 (extracellular space), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)