Protein: Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (P01587)
Organism: Mus musculus (Mouse)
Function: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Subcellular location: Secreted.
Sequence: MWLQNLLFLGIVVYSLSAPTRSPITVTRPWKHVEAIKEALNLLDDMPVTLNEEVEVVSNEFSFKKLTCVQTRLKIFEQGLRGNFTKLKGALNMTASYYQTYCPPTPETDCETQVTTYADFIDSLKTFLTDIPFECKKPGQK
InterPro domains: - IPR000773: Granulocyte-macrophage colony-stimulating factor (family) [1-141]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [18-141]
Interaction partners: - Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
- Cytokine receptor common subunit beta
- Granulocyte colony-stimulating factor
- Interleukin-1 beta
- Interleukin-3
- Interleukin-2
- Interleukin-3 receptor class 2 subunit beta
- Eotaxin
- Interleukin-1 alpha
- Interferon gamma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005125 (cytokine activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0001775 (cell activation), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0001817 (regulation of cytokine production), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0051128 (regulation of cellular component organization), GO:0008284 (positive regulation of cell population proliferation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0051130 (positive regulation of cellular component organization), GO:0031324 (negative regulation of cellular metabolic process), GO:0010033 (response to organic substance), GO:0043170 (macromolecule metabolic process), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0002274 (myeloid leukocyte activation), GO:0080090 (regulation of primary metabolic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0010743 (regulation of macrophage derived foam cell differentiation), GO:0070663 (regulation of leukocyte proliferation), GO:0001773 (myeloid dendritic cell activation), GO:0010468 (regulation of gene expression), GO:1901099 (negative regulation of signal transduction in absence of ligand), GO:0043412 (macromolecule modification), GO:1902117 (positive regulation of organelle assembly), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0070665 (positive regulation of leukocyte proliferation), GO:0051252 (regulation of RNA metabolic process), GO:0019221 (cytokine-mediated signaling pathway), GO:0010744 (positive regulation of macrophage derived foam cell differentiation), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0030097 (hemopoiesis), GO:0034097 (response to cytokine), GO:0002521 (leukocyte differentiation), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0071310 (cellular response to organic substance), GO:0097696 (receptor signaling pathway via STAT), GO:0010628 (positive regulation of gene expression), GO:2001234 (negative regulation of apoptotic signaling pathway), GO:0006796 (phosphate-containing compound metabolic process), GO:2001233 (regulation of apoptotic signaling pathway), GO:0030099 (myeloid cell differentiation), GO:1902115 (regulation of organelle assembly), GO:0036211 (protein modification process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0033043 (regulation of organelle organization), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0051253 (negative regulation of RNA metabolic process), GO:0010638 (positive regulation of organelle organization), GO:0051174 (regulation of phosphorus metabolic process), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0043011 (myeloid dendritic cell differentiation), GO:0042981 (regulation of apoptotic process), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0071345 (cellular response to cytokine stimulus), GO:0016310 (phosphorylation), GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:1903131 (mononuclear cell differentiation), GO:0002573 (myeloid leukocyte differentiation), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0007259 (receptor signaling pathway via JAK-STAT), GO:0031401 (positive regulation of protein modification process), GO:0031399 (regulation of protein modification process), GO:2001239 (regulation of extrinsic apoptotic signaling pathway in absence of ligand), GO:0043066 (negative regulation of apoptotic process), GO:0006468 (protein phosphorylation), GO:0006355 (regulation of DNA-templated transcription), GO:0019220 (regulation of phosphate metabolic process), GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway), GO:2001236 (regulation of extrinsic apoptotic signaling pathway), GO:0001932 (regulation of protein phosphorylation), GO:0045892 (negative regulation of DNA-templated transcription), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0042325 (regulation of phosphorylation), GO:0097028 (dendritic cell differentiation), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0030225 (macrophage differentiation), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)