Protein: Dynein regulatory complex subunit 3 (Leucine-rich repeat-containing protein 48) (Q9H069)
Organism: Homo sapiens (Human)
Function: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23354437}. Cell projection, cilium {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8IVX2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D5E4}.
Sequence: MNQPCNSMEPRVMDDDMLKLAVGDQGPQEEAGQLAKQEGILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQEKRKTELDTFSECVREAIQENQEQGKRKIAKFEEKHLSSLSAIREELELPNIEKMILECSADISELFDALMTLEMQLVEQLEETINMFERNIVDMVGLFIENVQSLMAQCRDLENHHHEKLLEISISTLEKIVEGDLDEDLPNDLRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTRINSWCTRLIDRIHKDEIMRNRKRVKEINQYIDHMQSELDNLECGDILD
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [35-206]
- IPR001611: Leucine-rich repeat (repeat) [66-153]
- IPR050576: Ciliary and flagellar integrity-associated protein (family) [40-472]
Interaction partners: - Radial spoke head protein 4 homolog A
- Coiled-coil domain-containing protein 40
- Dynein regulatory complex subunit 4
- Dynein regulatory complex subunit 2
- Radial spoke head protein 6 homolog A
- Dynein regulatory complex subunit 5
- F-box and leucine-rich repeat protein 13
- Outer dynein arm-docking complex subunit 1
- Dynein regulatory complex subunit 7
- Dynein regulatory complex protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0071840 (cellular component organization or biogenesis), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0060341 (regulation of cellular localization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:0070201 (regulation of establishment of protein localization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0006997 (nucleus organization), GO:0006999 (nuclear pore organization), GO:0046931 (pore complex assembly), GO:0051292 (nuclear pore complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0031974 (membrane-enclosed lumen), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005654 (nucleoplasm), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)