Protein: ATP-binding cassette sub-family D member 2 (EC 3.1.2.-) (EC 7.6.2.-) (Adrenoleukodystrophy-related protein) (Q61285)
Organism: Mus musculus (Mouse)
Function: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen (By similarity). Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (By similarity). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro) (By similarity). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
Subcellular location: Peroxisome membrane {ECO:0000269|PubMed:8577752}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MIHMLNAAAYRVKWTRSGAAKRAACLVAAAYALKTLYPIIGKRLKQPGHRKAKAEAYSPAENREILHCTEIICKKPAPGLNAAFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFANQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVILTSYTLIRTATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGSLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKCYKALAYQMNLILSKRLWYIMIEQFLMKYVWSSCGLIMVAIPIITATGFADGDLEDGPKQAMVSDRTEAFTTARNLLASGADAIERIMSSYKEITELAGYTARVYNMFWVFDEVKRGIYKRTVTQEPENHSKRGGNLELPLSDTLAIKGTVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSADDMREKGYTDQDLERILHSVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAIGAGISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIQTAEKTS
InterPro domains: - IPR017871: ABC transporter-like, conserved site (conserved_site) [610-624]
- IPR036640: ABC transporter type 1, transmembrane domain superfamily (homologous_superfamily) [95-429]
- IPR003593: AAA+ ATPase domain (domain) [504-690]
- IPR050835: ATP-binding cassette sub-family D (family) [54-691]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [471-710]
- IPR003439: ABC transporter-like, ATP-binding domain (domain) [479-705]
- IPR011527: ABC transporter type 1, transmembrane domain (domain) [91-365]
Interaction partners: - ATP-binding cassette sub-family D member 3
- ATP-binding cassette sub-family D member 1
- Peroxisomal biogenesis factor 19
- Peroxisomal membrane protein 11B
- Peroxisomal membrane protein PMP34
- Peroxisomal membrane protein PEX13
- Peroxisomal membrane protein 4
- Peroxisomal membrane protein PEX16
- Peroxisome assembly protein 12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0051241 (negative regulation of multicellular organismal process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0007272 (ensheathment of neurons), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0007275 (multicellular organism development), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0055088 (lipid homeostasis), GO:0080134 (regulation of response to stress), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0044255 (cellular lipid metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0001817 (regulation of cytokine production), GO:0009894 (regulation of catabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0042391 (regulation of membrane potential), GO:0016043 (cellular component organization), GO:1901575 (organic substance catabolic process), GO:1901576 (organic substance biosynthetic process), GO:0008366 (axon ensheathment), GO:0044282 (small molecule catabolic process), GO:0080135 (regulation of cellular response to stress), GO:0044249 (cellular biosynthetic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0062013 (positive regulation of small molecule metabolic process), GO:0003254 (regulation of membrane depolarization), GO:0006629 (lipid metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0062012 (regulation of small molecule metabolic process), GO:0001818 (negative regulation of cytokine production), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0045834 (positive regulation of lipid metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0050996 (positive regulation of lipid catabolic process), GO:0055089 (fatty acid homeostasis), GO:0030030 (cell projection organization), GO:0043436 (oxoacid metabolic process), GO:2000378 (negative regulation of reactive oxygen species metabolic process), GO:1903427 (negative regulation of reactive oxygen species biosynthetic process), GO:0044242 (cellular lipid catabolic process), GO:0051881 (regulation of mitochondrial membrane potential), GO:0016042 (lipid catabolic process), GO:0010468 (regulation of gene expression), GO:0051900 (regulation of mitochondrial depolarization), GO:1900407 (regulation of cellular response to oxidative stress), GO:0006631 (fatty acid metabolic process), GO:0016054 (organic acid catabolic process), GO:0007399 (nervous system development), GO:0045923 (positive regulation of fatty acid metabolic process), GO:0055092 (sterol homeostasis), GO:0016053 (organic acid biosynthetic process), GO:1902882 (regulation of response to oxidative stress), GO:1903426 (regulation of reactive oxygen species biosynthetic process), GO:0030258 (lipid modification), GO:0008610 (lipid biosynthetic process), GO:0010629 (negative regulation of gene expression), GO:0061024 (membrane organization), GO:0010565 (regulation of cellular ketone metabolic process), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0042552 (myelination), GO:0010256 (endomembrane system organization), GO:0046889 (positive regulation of lipid biosynthetic process), GO:1900015 (regulation of cytokine production involved in inflammatory response), GO:1900016 (negative regulation of cytokine production involved in inflammatory response), GO:0046890 (regulation of lipid biosynthetic process), GO:0043467 (regulation of generation of precursor metabolites and energy), GO:0031326 (regulation of cellular biosynthetic process), GO:0050994 (regulation of lipid catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0019216 (regulation of lipid metabolic process), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0042304 (regulation of fatty acid biosynthetic process), GO:0046321 (positive regulation of fatty acid oxidation), GO:0019752 (carboxylic acid metabolic process), GO:0006633 (fatty acid biosynthetic process), GO:0019395 (fatty acid oxidation), GO:0043457 (regulation of cellular respiration), GO:0009062 (fatty acid catabolic process), GO:0019217 (regulation of fatty acid metabolic process), GO:0032000 (positive regulation of fatty acid beta-oxidation), GO:0031998 (regulation of fatty acid beta-oxidation), GO:0046395 (carboxylic acid catabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0120036 (plasma membrane bounded cell projection organization), GO:0045723 (positive regulation of fatty acid biosynthetic process), GO:0007009 (plasma membrane organization), GO:0034440 (lipid oxidation), GO:0000038 (very long-chain fatty acid metabolic process), GO:0032787 (monocarboxylic acid metabolic process), GO:0072329 (monocarboxylic acid catabolic process), GO:0046320 (regulation of fatty acid oxidation), GO:1903715 (regulation of aerobic respiration), GO:2001279 (regulation of unsaturated fatty acid biosynthetic process), GO:0072330 (monocarboxylic acid biosynthetic process), GO:0106027 (neuron projection organization), GO:0006635 (fatty acid beta-oxidation), GO:0030497 (fatty acid elongation), GO:0002082 (regulation of oxidative phosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0042579 (microbody), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005777 (peroxisome), GO:0098588 (bounding membrane of organelle), GO:0031903 (microbody membrane), GO:0005778 (peroxisomal membrane)