Protein: Ras-like protein 1 (Q59XU5)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side
Sequence: MLREYKLVVVGGGGVGKSALTIQLIQSHFVDEYDPTIEDSYRKQCTIDDQQVLLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSINSLNSFQELNSFYDQILRVKDSDNVPVLVVGNKCDLEMERQVSYEDGLALANSFNCPFLETSAKQRINVEEAFYGLVRNINQYNAKIAEAEKQQQQQQQQQNANQQGQDQYGQQKDNQQSQFNNQINNNNNTSAVNGGVSSDGIIDQNGNGGVSSGQANLPNQSQSQSQRQQQQQQQEPQQQSENQFSGQKQSSSKSKNGCCVIV
InterPro domains: - IPR001806: Small GTPase (family) [1-290]
- IPR020849: Small GTPase, Ras-type (family) [4-190]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [2-184]
- IPR005225: Small GTP-binding domain (domain) [3-159]
Interaction partners: - Adenylate cyclase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase
- Gpr1p
- Ras GTPase activating protein
- Rga2p
- Ras2p
- Rho family guanine nucleotide exchange factor
- Cell division control protein 25
- Serine/threonine-protein kinase SCH9
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0040007 (growth), GO:0023052 (signaling), GO:0051703 (biological process involved in intraspecies interaction between organisms), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0007155 (cell adhesion), GO:0044010 (single-species biofilm formation), GO:0098743 (cell aggregation), GO:0045927 (positive regulation of growth), GO:0044403 (biological process involved in symbiotic interaction), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0036166 (phenotypic switching), GO:0048522 (positive regulation of cellular process), GO:0009266 (response to temperature stimulus), GO:0010942 (positive regulation of cell death), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0035556 (intracellular signal transduction), GO:0080134 (regulation of response to stress), GO:0010570 (regulation of filamentous growth), GO:0033500 (carbohydrate homeostasis), GO:0075136 (response to host), GO:1901700 (response to oxygen-containing compound), GO:1900239 (regulation of phenotypic switching), GO:0090609 (single-species submerged biofilm formation), GO:0060258 (negative regulation of filamentous growth), GO:0010033 (response to organic substance), GO:0009408 (response to heat), GO:1900190 (regulation of single-species biofilm formation), GO:0051701 (biological process involved in interaction with host), GO:0009991 (response to extracellular stimulus), GO:0055082 (intracellular chemical homeostasis), GO:0002831 (regulation of response to biotic stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0098630 (aggregation of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0010941 (regulation of cell death), GO:0002833 (positive regulation of response to biotic stimulus), GO:0033554 (cellular response to stress), GO:0031668 (cellular response to extracellular stimulus), GO:0090033 (positive regulation of filamentous growth), GO:0071496 (cellular response to external stimulus), GO:0009743 (response to carbohydrate), GO:0052200 (response to host defenses), GO:0097305 (response to alcohol), GO:1900231 (regulation of single-species biofilm formation on inanimate substrate), GO:0071310 (cellular response to organic substance), GO:0009267 (cellular response to starvation), GO:0043067 (regulation of programmed cell death), GO:1900445 (positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0043709 (cell adhesion involved in single-species biofilm formation), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0043708 (cell adhesion involved in biofilm formation), GO:0044011 (single-species biofilm formation on inanimate substrate), GO:0032104 (regulation of response to extracellular stimulus), GO:0019932 (second-messenger-mediated signaling), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0042593 (glucose homeostasis), GO:0034605 (cellular response to heat), GO:0032106 (positive regulation of response to extracellular stimulus), GO:0042710 (biofilm formation), GO:0007264 (small GTPase mediated signal transduction), GO:0001678 (intracellular glucose homeostasis), GO:0031669 (cellular response to nutrient levels), GO:1901701 (cellular response to oxygen-containing compound), GO:0071322 (cellular response to carbohydrate stimulus), GO:0071333 (cellular response to glucose stimulus), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0034284 (response to monosaccharide), GO:0071396 (cellular response to lipid), GO:0007265 (Ras protein signal transduction), GO:0090605 (submerged biofilm formation), GO:0030682 (mitigation of host defenses by symbiont), GO:0097306 (cellular response to alcohol), GO:0097307 (response to farnesol), GO:0019933 (cAMP-mediated signaling), GO:0071326 (cellular response to monosaccharide stimulus), GO:0097308 (cellular response to farnesol), GO:0009746 (response to hexose), GO:0071331 (cellular response to hexose stimulus), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0030428 (cell septum), GO:0016020 (membrane), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0140535 (intracellular protein-containing complex), GO:0000131 (incipient cellular bud site), GO:0005935 (cellular bud neck), GO:0005938 (cell cortex), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009277 (fungal-type cell wall)