Protein: T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) (Chaperonin containing TCP1 subunit 1) (P12613)
Organism: Drosophila melanogaster (Fruit fly)
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
Subcellular location: Cytoplasm.
Sequence: MSTLASPLSIAGTRQSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIISGYRIACKEACKYISEHLTAPVDELGRDSLINIAKTSMSSKIIGADAEFFSAMVVDAAQSVKITDPRGQAAYSIKAINVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLINDPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAITILRIDDMIKLNPEDKSGKSYADACAAGELDG
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [141-409]
- IPR053374: TCP-1 chaperonin-containing T-complex (family) [13-534]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [210-382]
- IPR054827: Thermosome subunit alpha (family) [13-535]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [31-536]
- IPR002194: Chaperonin TCP-1, conserved site (conserved_site) [36-93]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [14-536]
- IPR017998: Chaperone tailless complex polypeptide 1 (TCP-1) (family) [15-536]
- IPR012715: T-complex protein 1, alpha subunit (family) [9-541]
Interaction partners: - T-complex protein 1 subunit theta
- T-complex protein 1 subunit delta
- T-complex protein 1 subunit epsilon
- T-complex protein 1 subunit eta
- T-complex protein 1 subunit beta
- Chaperonin containing TCP1 subunit 6
- T-complex protein 1 subunit gamma
- Uncharacterized protein
- Phosducin-like protein 2
- 60 kDa heat shock protein homolog 1, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0001763 (morphogenesis of a branching structure), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0035295 (tube development), GO:0048729 (tissue morphogenesis), GO:0035148 (tube formation), GO:0009888 (tissue development), GO:0035152 (regulation of tube architecture, open tracheal system), GO:0048731 (system development), GO:0061138 (morphogenesis of a branching epithelium), GO:0035239 (tube morphogenesis), GO:0035149 (lumen formation, open tracheal system), GO:0060562 (epithelial tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0060429 (epithelium development), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0060541 (respiratory system development), GO:0060446 (branching involved in open tracheal system development), GO:0007424 (open tracheal system development), GO:0007430 (terminal branching, open tracheal system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)