Protein: BHLH-PAS protein similar to human NXF (Q2WGN8)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MPNAIGASSITKWISQIESFEQRELVTNICKRAIDDMYADNKRGLDKVTAATPPTHALQQQQQQQHPHQQQQHLQHVLQLQQQQQQHLQQQQHHLQHQMHTHHNFQQHETSPTVSQQQHMQQQQPQTTQQQHATQQQQQQQQQTAGMFTRFDANKSTKGASKMRRDLINAEIANLRDLLPLPQSTRQRLSQLQLMALVCVYVRKANYFQQVFKRHNAMHHLHHQTATPNIGFSKALSGFLMMLTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYDIIDKQDHANIQAELNRNVPPQPGGSSQASSGGAGGAGGAGDSTSSNGSAAGAGGAGGASSLEGEHRMFLCRMNVSRNARRQMRFGDQKVVLVQGHYLSFLPLCSRNEPVFLATCTPIAMPETRECVVQGATNVFTTIHSMDMKIAHIDKNGEFHLGYDKSTLQGTSWYNLIHSDNLTEAQKKHSLIIQSEQDRSCILLVRMQRSSGEYTWVHVVLQVRDSPDSTQQPVIVCTNQVLNDREASIMLANSWLYHYYTVQSKIQFGMPLDSGIRVPPGTPSSGYYSPHSSHPPATPGGATPNLGIASSFGPHHHPHHSHHPHHHHHHHHPATAYHHHPHMGTYGGVYHAKAAIELKEDQPLFCFQEPVDYSQVNSHVNPPNATSTPNPPISKSSTPPPPKKRARKLEPLYLHAERSPAAAITPEPDCYAIHTHPAAAYATSSVVSSDASVIYATIVPTRPRLPNKSLPPDPADFIEQWNPSPPWSESAQKASLDSFGSSHELSPCITTTPPTPTSATPHQSGLGTTQTIGPAFSFEWMSDPLVPVTYQQWPPTGDHHQHLSQHLSQSQNHQNPLQQQQQHEQLLLGQQPHLHQQHQHLALHHGRGEHSLEGESQGVVVVPPIPISIPIPTATGHGDAGQPVEDRG
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [152-205]
- IPR035965: PAS domain superfamily (homologous_superfamily) [237-512]
- IPR056192: NPAS4, bHLH domain (domain) [155-205]
- IPR000014: PAS domain (domain) [227-506]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0046983 (protein dimerization activity), GO:0003677 (DNA binding), GO:0046982 (protein heterodimerization activity), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0090130 (tissue migration), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0001763 (morphogenesis of a branching structure), GO:0035295 (tube development), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0048731 (system development), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0090132 (epithelium migration), GO:0060255 (regulation of macromolecule metabolic process), GO:0061138 (morphogenesis of a branching epithelium), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0016477 (cell migration), GO:0009891 (positive regulation of biosynthetic process), GO:0035239 (tube morphogenesis), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0010631 (epithelial cell migration), GO:0051254 (positive regulation of RNA metabolic process), GO:0060562 (epithelial tube morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0035146 (tube fusion), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0002009 (morphogenesis of an epithelium), GO:0051252 (regulation of RNA metabolic process), GO:0060429 (epithelium development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0010468 (regulation of gene expression), GO:0001667 (ameboidal-type cell migration), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0060541 (respiratory system development), GO:0007427 (epithelial cell migration, open tracheal system), GO:0035147 (branch fusion, open tracheal system), GO:1902680 (positive regulation of RNA biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0060446 (branching involved in open tracheal system development), GO:0006355 (regulation of DNA-templated transcription), GO:0007424 (open tracheal system development), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)