Protein: ATPase MORC2A (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2A) (Zinc finger CW-type coiled-coil domain protein 1) (Q69ZX6)
Organism: Mus musculus (Mouse)
Function: Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity).
Subcellular location: Nucleus {ECO:0000269|PubMed:29728365}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y6X9}. Chromosome {ECO:0000250|UniProtKB:Q9Y6X9}. Nucleus matrix {ECO:0000250|UniProtKB:Q9Y6X9}. Note=Mainly located in the nucleus. Upon phosphorylation at Ser-737, recruited to damaged chromatin. {ECO:0000250|UniProtKB:Q9Y6X9}.
Sequence: MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNTAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVETDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPIEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETSTSRLLQPTEAPRKPANPPIKTVPRPTPPVHTPPLSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVSDEEEAEEEAEKRRERCKRGKLAVKEEKKEANELSDSAGEDHPAELRKAQKDKGLHVEVRVNREWYTGRVTAVEVGKNAVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVARQAVALPEPSTSDGLPIEPDTTATSPSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [23-278]
- IPR011124: Zinc finger, CW-type (domain) [490-544]
- IPR041006: Morc, S5 domain 2-like (domain) [330-451]
- IPR056360: ATPase MORC2, chromo domain-like (domain) [790-853]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050896 (response to stimulus), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0044237 (cellular metabolic process), GO:0051321 (meiotic cell cycle), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:1903046 (meiotic cell cycle process), GO:0006950 (response to stress), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0061982 (meiosis I cell cycle process), GO:0007276 (gamete generation), GO:0007059 (chromosome segregation), GO:1901360 (organic cyclic compound metabolic process), GO:0140013 (meiotic nuclear division), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0033554 (cellular response to stress), GO:0070192 (chromosome organization involved in meiotic cell cycle), GO:0016043 (cellular component organization), GO:0045132 (meiotic chromosome segregation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007131 (reciprocal meiotic recombination), GO:0045143 (homologous chromosome segregation), GO:0098813 (nuclear chromosome segregation), GO:0090304 (nucleic acid metabolic process), GO:0006974 (cellular response to DNA damage stimulus), GO:0006259 (DNA metabolic process), GO:0007129 (homologous chromosome pairing at meiosis), GO:0006996 (organelle organization), GO:0007127 (meiosis I), GO:0048285 (organelle fission), GO:0006310 (DNA recombination), GO:0006281 (DNA repair), GO:0051276 (chromosome organization), GO:0000280 (nuclear division), GO:0035825 (homologous recombination), GO:0006302 (double-strand break repair), GO:0140527 (reciprocal homologous recombination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)