Protein: Transmembrane protein 174 (Q9DCX7)
Organism: Mus musculus (Mouse)
Function: Regulator of plasma phosphate homeostasis. Decreases serum inorganic phosphate (Pi) uptake by regulating the sodium-phosphate cotransporter SLC34A1 trafficking by PTH and FGF23 in the kidney
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Colocalizes with SLC34A1 in the plasma membrane of renal proximal tubule cells
Sequence: MEHSSNRPEDFPLNVFSVTPYTPSTADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKMLSCQLCSDNEERVPDSDQTSGGQSFVFTGINQPITFHGATVVQYIPPPYGSQEPLGMNATYLQPMMNPCGLIPPSGAAAAAPSPPQYYTIYPQDNAAFVESEGFSPFVGTGYDRPDSDADQLEGTELEEEDCVCFSPPPYEEIYALPR
InterPro domains: - IPR027835: Transmembrane protein 174 (family) [1-243]
Interaction partners: - Meprin A subunit alpha
- Sodium-dependent phosphate transport protein 2A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0001704 (formation of primary germ layer), GO:0048729 (tissue morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0048333 (mesodermal cell differentiation), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0001707 (mesoderm formation), GO:0007369 (gastrulation), GO:0048332 (mesoderm morphogenesis), GO:1902533 (positive regulation of intracellular signal transduction), GO:0007498 (mesoderm development), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0043410 (positive regulation of MAPK cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0010008 (endosome membrane), GO:0098588 (bounding membrane of organelle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012506 (vesicle membrane), GO:0097708 (intracellular vesicle)