Protein: Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1) (P49675)
Organism: Homo sapiens (Human)
Function: Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
Subcellular location: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
Sequence: MLLATFKLCAGSSYRHMRNMKGLRQQAVMAISQELNRRALGGPTPSTWINQVRRRSSLLGSRLEETLYSDQELAYLQQGEEAMQKALGILSNQEGWKKESQQDNGDKVMSKVVPDVGKVFRLEVVVDQPMERLYEELVERMEAMGEWNPNVKEIKVLQKIGKDTFITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATDFGNMPEQKGVIRAEHGPTCMVLHPLAGSPSKTKLTWLLSIDLKGWLPKSIINQVLSQTQVDFANHLRKRLESHPASEARC
InterPro domains: - IPR023393: START-like domain superfamily (homologous_superfamily) [65-284]
- IPR002913: START domain (domain) [67-281]
- IPR029866: Steroidogenic acute regulatory protein (family) [1-283]
- IPR000799: Steroidogenic acute regulatory protein-like (family) [5-283]
Interaction partners: - Non-selective voltage-gated ion channel VDAC1
- Translocator protein
- STARD3 N-terminal-like protein
- Cholesterol side-chain cleavage enzyme, mitochondrial
- Steroidogenic factor 1
- Non-selective voltage-gated ion channel VDAC2
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Adrenodoxin, mitochondrial
- Cytochrome P450 11B2, mitochondrial
- Non-selective voltage-gated ion channel VDAC3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0005515 (protein binding), GO:0005319 (lipid transporter activity), GO:0120013 (lipid transfer activity), GO:0015248 (sterol transporter activity), GO:0120015 (sterol transfer activity), GO:0120020 (cholesterol transfer activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0048519 (negative regulation of biological process), GO:0022406 (membrane docking), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0021700 (developmental maturation), GO:0048523 (negative regulation of cellular process), GO:0042445 (hormone metabolic process), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0042445 (hormone metabolic process), GO:0065008 (regulation of biological quality), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0044238 (primary metabolic process), GO:0051640 (organelle localization), GO:0048522 (positive regulation of cellular process), GO:0042180 (cellular ketone metabolic process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0048729 (tissue morphogenesis), GO:0120254 (olefinic compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0032990 (cell part morphogenesis), GO:0046907 (intracellular transport), GO:0051656 (establishment of organelle localization), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0046907 (intracellular transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0051646 (mitochondrion localization), GO:0051656 (establishment of organelle localization), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0010817 (regulation of hormone levels), GO:0042448 (progesterone metabolic process), GO:0007283 (spermatogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0032365 (intracellular lipid transport), GO:0010628 (positive regulation of gene expression), GO:0007286 (spermatid development), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0016482 (cytosolic transport), GO:0002688 (regulation of leukocyte chemotaxis), GO:0008610 (lipid biosynthetic process), GO:0010467 (gene expression), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0007005 (mitochondrion organization), GO:0070584 (mitochondrion morphogenesis), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:0045727 (positive regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0006368 (transcription elongation by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen)