Protein: Doublesex- and mab-3-related transcription factor A2 (Doublesex- and mab-3-related transcription factor 5) (Q96SC8)
Organism: Homo sapiens (Human)
Function: May be involved in sexual development.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Sequence: MELRSELPSVPGAATAAAATATGPPVASVASVAAAAAAAASLPVSVAGGLLRGPPLLLRAAEKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLIAERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPAYEVFGSVCAADGGGPGAGAPAGTGGGAAGAGGSEAKLQKFDLFPKTLLQAGRPGSPLPPPVKPLSPDGADSGPGTSSPEVRPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGPGGGGEEDSPGSASPLGSESGSEADKEEGEAAPAPGLGGGSGPRQRTPLDILTRVFPGHRRGVLELVLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPPDKAAVGAAAAADDAWPSRVDAAAAAAAAAGGPGLPAPLQAGPAAPPHHRPLLAGAMAPGALGSLSSRSAFSPLQPNASHFGADAGAYPLGAPLGLSPLRLAYSAAAAHSRGLAFMAPYSTAGLVPTLGFRPPMDYAFSDLMRDRSAAAAAAVHKEPTYGGGLYGPMVNGAPEKQ
InterPro domains: - IPR005173: DMRTA motif (domain) [314-350]
- IPR001275: DM DNA-binding domain (domain) [66-119]
- IPR009060: UBA-like superfamily (homologous_superfamily) [310-355]
- IPR036407: DM DNA-binding domain superfamily (homologous_superfamily) [63-112]
- IPR026607: DMRT family (family) [29-477]
- IPR046472: DMRT5/1, DMB domain (domain) [434-514]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0042802 (identical protein binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:1990837 (sequence-specific double-stranded DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0050793 (regulation of developmental process), GO:0007275 (multicellular organism development), GO:0048522 (positive regulation of cellular process), GO:0008283 (cell population proliferation), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0050794 (regulation of cellular process), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0045165 (cell fate commitment), GO:0045597 (positive regulation of cell differentiation), GO:0061061 (muscle structure development), GO:0061351 (neural precursor cell proliferation), GO:0021987 (cerebral cortex development), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0021537 (telencephalon development), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0030900 (forebrain development), GO:0048513 (animal organ development), GO:0001708 (cell fate specification), GO:0021543 (pallium development), GO:0045595 (regulation of cell differentiation), GO:0051962 (positive regulation of nervous system development), GO:0008284 (positive regulation of cell population proliferation), GO:0007405 (neuroblast proliferation), GO:0048866 (stem cell fate specification), GO:0022008 (neurogenesis), GO:0048863 (stem cell differentiation), GO:0048665 (neuron fate specification), GO:0007399 (nervous system development), GO:0048865 (stem cell fate commitment), GO:0048663 (neuron fate commitment), GO:0060284 (regulation of cell development), GO:0060537 (muscle tissue development), GO:0010720 (positive regulation of cell development), GO:2000179 (positive regulation of neural precursor cell proliferation), GO:0007417 (central nervous system development), GO:0050769 (positive regulation of neurogenesis), GO:0007420 (brain development), GO:0051960 (regulation of nervous system development), GO:0007517 (muscle organ development), GO:0021871 (forebrain regionalization), GO:0030182 (neuron differentiation), GO:0035914 (skeletal muscle cell differentiation), GO:2000177 (regulation of neural precursor cell proliferation), GO:0007519 (skeletal muscle tissue development), GO:0071542 (dopaminergic neuron differentiation), GO:1902692 (regulation of neuroblast proliferation), GO:0050767 (regulation of neurogenesis), GO:0048699 (generation of neurons), GO:0060538 (skeletal muscle organ development), GO:0002052 (positive regulation of neuroblast proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)