Protein: Transcriptional regulator MNL1 (Q59RR3)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1
Subcellular location: Nucleus
Sequence: MDSHNNIDQSVSELLSDPASVQQSYNSQLRGPEFDQQRQIRNQVSPFNKMTDTIDNDNIPLSSDYDKLYQQFSIPSQQQYENNSDNVYKTNNDLAALASPLNMDLDLAPSDQQQQPQQSQQQFLNDFSNLQPHLNNSQEQVQLNGLTSNILSNPQITVNMPGAYHQNYNCDQMEIDDSPPFTIESDLYFEQQTDNNSIVTSNRVHNQPDVESMFNNQLSVPSLQRTELSPQQHETNVTTGRPQESAFGSFDNNSRVSSFANVNNAGTNLFVNGKDLYFDDESHHRTGRLRNGSIDSYYAANVINHQLHLQQQTQAQAQAHQQQQQQSQQQHSPQDLASHTSLPSKSIYNELSPLTTTTSRASSIQSGQPSFFSAQQYFSRNSMDQVPSSLHRPSFDLYNHRPSIDSQHSQQSQQRNARYTSFTSSISNILPFMSEKNTNHNNRSPPTPPTSTSSPQNLLSSNQSRHLIRSIFKTNPTPIVSDAGNSNGNIVNGGSGTIDAENLPDAPYASGTINDSEFLILSSPTKEEPEDELMQPKKVKKPKRSLFTRFKTPVKQEQPDSEMAVSAPVDELKPDETVIDMVGNISSHHSSGTPSITTGAGGNTLEHSISESSFQEPDYAALFENVGKRKNKSYRKPKGKTKEEEQQQQQLPLSSGTAGGTSSNNSTGTVEKTLFFNKTKIKKEPASERSSLLDNASAGNASASSSEASSIQNAIGSDDHNGPPLTSAPTSSTLANASKRILSSKLISKKKSTSKLKEYTAAELEDMCTVSSLETPVATMISKGIEVEVDLASLDLPPDTKIFPTSIINNKNRTRGRKENKEADLSDTSKIYLCNLCQRRFKRHEHLKRHFRSLHTFEKPYNCDICHKKFSRSDNLNQHLKIHKQEDEKDCADAETGVGMDDASG
InterPro domains: - IPR052127: STE12 transcription factor (family) [587-887]
- IPR013087: Zinc finger C2H2-type (domain) [832-888]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [830-883]
Interaction partners: - non-specific serine/threonine protein kinase
- Serine/threonine-protein kinase SCH9
- Transcriptional regulator SKO1
- Transcription factor SKN7
- Ras-like protein 1
- Mitogen-activated protein kinase HOG1
- Transcription activator GCR1-like domain-containing protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0045927 (positive regulation of growth), GO:0040008 (regulation of growth), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0104004 (cellular response to environmental stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0071214 (cellular response to abiotic stimulus), GO:0010570 (regulation of filamentous growth), GO:0006970 (response to osmotic stress), GO:0090033 (positive regulation of filamentous growth), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0062197 (cellular response to chemical stress), GO:0071470 (cellular response to osmotic stress), GO:1900445 (positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0070784 (regulation of growth of unicellular organism as a thread of attached cells)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)