Protein: Tyrosine-protein kinase transmembrane receptor Ror2 (dRor2) (EC 2.7.10.1) (Neurospecific receptor tyrosine kinase) (Q9V6K3)
Organism: Drosophila melanogaster (Fruit fly)
Function: Tyrosine-protein kinase receptor that functions during early stages of neuronal development.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MAAGQWVGVVERVLRGMVLKWGANLAVLGLCVFLFASATHANSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQHSIAESECKAML
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [426-708]
- IPR000001: Kringle (domain) [216-299]
- IPR050122: Receptor Tyrosine Kinase (family) [154-713]
- IPR036790: Frizzled cysteine-rich domain superfamily (homologous_superfamily) [67-207]
- IPR013806: Kringle-like fold (homologous_superfamily) [215-304]
- IPR018056: Kringle, conserved site (conserved_site) [267-280]
- IPR038178: Kringle superfamily (homologous_superfamily) [208-301]
- IPR020067: Frizzled domain (domain) [65-205]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [443-710]
- IPR017441: Protein kinase, ATP binding site (binding_site) [447-475]
- IPR000719: Protein kinase domain (domain) [441-716]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [576-588]
- IPR016247: Tyrosine-protein kinase, receptor ROR (family) [1-724]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [441-711]
Interaction partners: - SP2353, isoform A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0038023 (signaling receptor activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0017147 (Wnt-protein binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0019899 (enzyme binding), GO:0016301 (kinase activity), GO:0019199 (transmembrane receptor protein kinase activity), GO:0019900 (kinase binding), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004713 (protein tyrosine kinase activity), GO:0001664 (G protein-coupled receptor binding), GO:0004714 (transmembrane receptor protein tyrosine kinase activity), GO:0005109 (frizzled binding), GO:0019901 (protein kinase binding), GO:0031435 (mitogen-activated protein kinase kinase kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023057 (negative regulation of signaling), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0007389 (pattern specification process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0033036 (macromolecule localization), GO:0007267 (cell-cell signaling), GO:0044237 (cellular metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0048729 (tissue morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0045165 (cell fate commitment), GO:0001709 (cell fate determination), GO:0009887 (animal organ morphogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0016358 (dendrite development), GO:0070727 (cellular macromolecule localization), GO:0007166 (cell surface receptor signaling pathway), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0006935 (chemotaxis), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:1901185 (negative regulation of ERBB signaling pathway), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0048663 (neuron fate commitment), GO:0048880 (sensory system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048732 (gland development), GO:0006796 (phosphate-containing compound metabolic process), GO:0002009 (morphogenesis of an epithelium), GO:0035272 (exocrine system development), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:1901184 (regulation of ERBB signaling pathway), GO:0008104 (protein localization), GO:0060429 (epithelium development), GO:0048858 (cell projection morphogenesis), GO:0022612 (gland morphogenesis), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0060541 (respiratory system development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0007431 (salivary gland development), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0007424 (open tracheal system development), GO:0150063 (visual system development), GO:0016310 (phosphorylation), GO:0035220 (wing disc development), GO:0007435 (salivary gland morphogenesis), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048699 (generation of neurons), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0007391 (dorsal closure), GO:0035222 (wing disc pattern formation), GO:0048749 (compound eye development), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0008045 (motor neuron axon guidance), GO:0001745 (compound eye morphogenesis), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0045211 (postsynaptic membrane), GO:0045202 (synapse), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane)