Protein: Calpain, putative (Q38C53)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MATTLDDLYQYYCRRKGCKANSCFSRYLIEEFERQGQKRVLETVDLSLNYVGRKGIIPVLDLVKNVKTIKKLNLSNNMLEHEELEHLVYCLALHPSVEEVVLANNCFHDASVKVILDLLELNGGITTFDVDGNEISAASVATIGEQLEKNRARRAERESDASHPSLRRWSKAQIEGSIDELNSGGHIHFGTWWKNPQYFMRTSAGSQVRIVMDVEDAKEARQVGFFVFRSSGQYRVVELSEGVIAGESACDHSHCYLTMSVEENETYSVMPYTFYPSRSVGFRLTAEMCSDDALSSRGWITLEPVDPAVDWCLSTLDGEWTEESAGGSHLEHTWCRNHMIRVQYAGSVLTHRMAAPATLIVKLSKGVDPDVNDEKSIGFHVLTPDTEEALLPPIFCKDECVKCFCPHERTTTISASFAVSCTALQLFIAPSTLNPGQVGSYNVTVFSSVPVTLSSSAFPHGWHYRKVGGSWDEYNCGGSRNASMSWKANPSIGLSVDSSQEPSDFTVFLEAASPALPLVVQEAAVGDGACSRSATPAPGESQEEDPDLVEFLRRHKAHLMEACVSVIEAKSPLYRELLTSGYTNGSFARLMVPGLNKPFLLLVSTRHAGQLGTFALHIFSHRPFVTDGVESLLAREREVHLQQYALENEKRRTLLSAAKTQQISFDGSEDVVVVRNEIIRQCMITGEKFVDRDFPRGGSSLFLDPDAKPPPMFPKETHWKRPTELMEKVVFLPDWKCDAPFPYSRREWFASVVHAIATKPLWLQNVAVGYNEGEGMAQFRFFKDGKWKVVTIDDYLLFDSTMDLCMGRPGKDSADIFFPLIEKAYAKAHRCYETLEPKVTPELGFLELVCQGLMDLSGCATINIPLIGSVRMPQEQQDVIWMEMKNAVKPNVLCSLLVRGDSNGASERRGRGILVDHIYPVLDARFLEGYRLVKLRHWGQPEEINLCSKWRSSSDKWTDTIRQTLEFREDDRETFWLSFDEVLYYFTNLLINEETSSVSWASGYFCDCPPGCNDRLLGSSQFSLQLGEFPPGLKKVNILLGLHQLDPRTTVLRDKEAVASYRTGVGLEVVGTADNTVWLTDFSKAEVLSRLEPCMKRDALCPLTVSLDSVGGNKLLTLVVFKEEMRAPHVPFLLSAWSETCKVNVVAVERNAAVTVCDEWPREFAIGGPSSPFWRDCPQYFIYPSDTTDINFSLKQELASGEIPKPIGFTVHDARACRSYLEYNPETVILSVAANASHKVEGTVRLLGMKARRGMPYIIVPFCTEAAPGGSFTLEAVANRFVKLCRINPQLDWCRVTKHASFMLSDGSVGGSLRFSSWRSSPQFAFTFPVGGKGRLLVSLSNDDAVDTRTEVGMTLLLGDRQWDEGKRRKLVVSQGDIIACSEENIGRSTLDCEIDVEPEQTLILVVYASLPYRGADVTFTAYSALPVEVEPVKEWEYVVMAQGSWELGYTAGGGAEEFGSWVNNPFVALNTFRRTQIVALLLQYPRGPEKPVVKRAGNKKAFLPPVIVNPNNRMEIAIDLNCQDENMTRIATTPYTRNSEVALVANVPAADSLPFVFVPHTKYPEGNGEYKLFVYADSLVELYPLEKKRVPYV
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [20-154]
- IPR001300: Peptidase C2, calpain, catalytic domain (domain) [676-996]
- IPR036213: Calpain large subunit, domain III superfamily (homologous_superfamily) [169-1587]
- IPR022684: Peptidase C2, calpain family (family) [673-1086]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [676-993]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity), GO:0004175 (endopeptidase activity), GO:0004197 (cysteine-type endopeptidase activity), GO:0004198 (calcium-dependent cysteine-type endopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0009607 (response to biotic stimulus), GO:0044145 (modulation of formation of structure involved in a symbiotic process), GO:0007154 (cell communication), GO:0051606 (detection of stimulus), GO:0009595 (detection of biotic stimulus), GO:0009372 (quorum sensing), GO:0060245 (detection of cell density)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005930 (axoneme), GO:0005737 (cytoplasm), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0099568 (cytoplasmic region), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0032838 (plasma membrane bounded cell projection cytoplasm), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0097014 (ciliary plasm)