Protein: Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48) (P9WFX7)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MSPATVLDSILEGVRADVAAREASVSLSEIKAAAAAAPPPLDVMAALREPGIGVIAEVKRASPSAGALATIADPAKLAQAYQDGGARIVSVVTEQRRFQGSLDDLDAVRASVSIPVLRKDFVVQPYQIHEARAHGADMLLLIVAALEQSVLVSMLDRTESLGMTALVEVHTEQEADRALKAGAKVIGVNARDLMTLDVDRDCFARIAPGLPSSVIRIAESGVRGTADLLAYAGAGADAVLVGEGLVTSGDPRAAVADLVTAGTHPSCPKPAR
InterPro domains: - IPR013798: Indole-3-glycerol phosphate synthase domain (domain) [5-260]
- IPR011060: Ribulose-phosphate binding barrel (homologous_superfamily) [15-260]
- IPR001468: Indole-3-glycerol phosphate synthase, conserved site (conserved_site) [54-71]
- IPR045186: Indole-3-glycerol phosphate synthase (family) [3-259]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1-272]
Interaction partners: - Tryptophan synthase alpha chain
- Tryptophan synthase beta chain
- Anthranilate synthase component 1
- Anthranilate synthase component 2
- Anthranilate phosphoribosyltransferase
- Phosphoribosyl isomerase A
- Salicylate synthase
- Probable para-aminobenzoate synthase component I PABD
- Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- Putative isochorismate synthase MenF
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016829 (lyase activity), GO:0016830 (carbon-carbon lyase activity), GO:0016831 (carboxy-lyase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0006082 (organic acid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0009072 (aromatic amino acid metabolic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0042430 (indole-containing compound metabolic process), GO:0009308 (amine metabolic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901605 (alpha-amino acid metabolic process), GO:0042435 (indole-containing compound biosynthetic process), GO:0019752 (carboxylic acid metabolic process), GO:0009073 (aromatic amino acid family biosynthetic process), GO:0006576 (biogenic amine metabolic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0006586 (indolalkylamine metabolic process), GO:0006568 (tryptophan metabolic process), GO:0009309 (amine biosynthetic process), GO:0046394 (carboxylic acid biosynthetic process), GO:0046219 (indolalkylamine biosynthetic process), GO:0000162 (tryptophan biosynthetic process), GO:0042401 (biogenic amine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)