Protein: Protein argonaute 1 (LbrAGO1) (G8XR08)
Organism: Leishmania braziliensis
Function: Involved in RNA-mediated gene silencing (RNAi) of mobile elements and repeats including retroposons SLACS (Spliced Leader Associated Conserved Sequence), TATE (Telomere-Associated Transposable Element) and TAS-like sequences (Telomere Associated Sequence), and a family of 74-nucleotide long tandem repeats, CIR74. Predominantly binds to siRNAs derived from SLACS and TATE transposable elements and to a lesser extent to siRNAs from TAS-like and CIR74 elements.
Subcellular location: Cytoplasm {ECO:0000305|PubMed:23217017}.
Sequence: MLALNAGSQYPGRGRGRGRGDGGNRVHKHDGINRYHGGFRGGRGGGGGGFRDGDMRECRERESWAVSAAQANARTLARVPVPVETNCFPIDLSEGRFHNYIVSFEFLENATDMAGDMWKISLQNELLRTIRKNRTAEKRTRTSAEVEDLCVCTGQAILAPAKLSVEDGFSIECTRKEKVSRNNTEERHYRVRIRYDGEVSLKLPEHAQWVNKIIAFGLADTYSEHIGSDYVDMKSTVERGGDLVTMDAISLNALRIVKQSGSTTAMMDVLQLDVSTKASTKTKCSDEMRRLRQQNPQGFRRAVNEALVGISVTTVFGEPTFLKVKAIDFNILASSPTMFKTNPEETFVEYFKRKYDAIIDPTLPMLYCIFADRTKMSRRMPYPADSLLLNKLNEAQLSKLPILCSIYPNERMKRIKAALERVLASPLMITVLQQYGVRIQPQFVKVSGRVLPAPTIYVPSGPNMFNRINTAEYTGQAGFALGLKDLQHPSQPCEFKTLLMDEYFMHGNITHWLQKYNVALPSPRKTSFDSAAQRITEGPGTFAMVKLRTKEAGAYNNFKERFARSSIVSQMAVVDLTRNVPQMITQQVAAKIGQLCFVADVDEAGKSFACRPLLIVGAVVGTAMNTMLEKYKSINVRLYTITFVAFLANGKSWKPYCMHHQVKGEEHVLYEDSDAASSHMSSTTLTVRRQNANEVLNNRFPDFLKEVTAHFKLNGKGSKGTMVLYRGAMTDAEVGFTANMDLVMEQVLPNWDTATVVVHPRSHFRMAWDPTTVFPHETASAYAGLSNVPRGFSTTDCRIILADSDPYTPVDSFYLSAANCTLGHAANTYYLVQKRAASISLMDLQKLTYNMCYMYPNKPDALPLPLPIKCAYEYARKYGSLKSVKELPTRMRPTMHYL
InterPro domains: - IPR032472: Argonaute linker 2 domain (domain) [410-456]
- IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [529-881]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [673-892]
- IPR003100: PAZ domain (domain) [282-427]
- IPR003165: Piwi domain (domain) [542-883]
- IPR036085: PAZ domain superfamily (homologous_superfamily) [292-420]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0039694 (viral RNA genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0039689 (negative stranded viral RNA replication), GO:0016070 (RNA metabolic process), GO:0032774 (RNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)