wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: O-methyltransferase kntB (A2QK65)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bicoumarin kotanin. The non-reducing polyketide synthase ktnS first catalyzes the formation of the pentaketidic 4,7- dihydroxy-5-methylcoumarin from acetyl coenzyme A and 4 malonyl coenzyme A molecules. Further O- methylation by ktnB leads to the formation of 7-demethylsiderin. Then, an oxidative phenol coupling catalyzed by the cytochrome P450 monooxygenase ktnC forms the 8,8'-dimer P-orlandin via dimerization the monomeric precursor, 7-demethylsiderin. P-orlandin is subsequently O-methylated in a stepwise fashion to demethylkotanin and kotanin
Sequence: MTYPEEIDEYSLIQNGLKSLNEAAQRCQQTKHSSQDSSIEGCSARQSARDELVLEALKFLQIAQGPIDAAATCYERTAHLASVRALLEMGVFEALPTGRVSRRTEELARELNVDESLLARLLRNSSLYGPFEETGPGQYRHTPFSEAYLRPEIRGMFRFAMDDHMPAHLKLHEFLQRNGWQEPSSTTDNPYTYAHKTNGKSMFDNLSEKPERMKAFNNGMTVQAMTPLWMIDLFPWRSLAQLKPTAGQVLAVDIGGGKGKAISRIRSFCNGLPGRYILQDQEHVVKSVEGSLDPSIERMAYNFFTEQPIRGAVTYLIRRCLHNWPQDSVVCILQNIAAAMEPGKSRLLIEEIVVPAEKAGVEEGWMDMIMMSLGAKQRTLKEWEMVLGLAGLEVKKVYQIPGNCHGLIEAWLK
InterPro domains: - IPR016461: O-methyltransferase-like (family) [71-412]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [69-156]
- IPR012967: O-methyltransferase, dimerisation domain (domain) [83-150]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [76-148]
- IPR001077: O-methyltransferase, C-terminal domain (domain) [195-392]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [154-411]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity), GO:0008171 (O-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Bicoumarin synthase ktnC (A2QK67)
Organism: Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Function: Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the bicoumarin kotanin. The non-reducing polyketide synthase ktnS first catalyzes the formation of the pentaketidic 4,7- dihydroxy-5-methylcoumarin from acetyl coenzyme A and 4 malonyl coenzyme A molecules. Further O- methylation by ktnB leads to the formation of 7-demethylsiderin. Then, an oxidative phenol coupling catalyzed by the cytochrome P450 monooxygenase ktnC forms the 8,8'-dimer P-orlandin via dimerization the monomeric precursor, 7-demethylsiderin. P-orlandin is subsequently O-methylated in a stepwise fashion to demethylkotanin and kotanin
Sequence: MHKSAALSLRDAQFADMNMYCDVTDRTPIEAVHSCNNAESLNILNKLLARETDTALSQIFEQPTGKDWKELNTLQTILSLCSTVTMALLLGPDTAPDPVLHHHSTSFGEAIMSSCYRRTGYPRILRPFVWRFSSECRNLRKHFSLVRERLVPEVARRVAAARAADKTKDVRPSSLLDALIAAAFDNGSLSPDDQGRNDAAQVQLLADDLIFYHFELCKPTAFNIIFQLYAIMDHPEYKAPLREEALQALKLTNGDWTVETLKHAPKLESFTKETFRLYDISGFVSFRRVMKPLTLNSIGLSLRPGTILLSPCRNVHLDPEIYEDPTTFNGYRFYDSSREVCSPRVATTSLTFLTFSHGAGSCPARVLATQICRTIFIKFLLQYDVEPVQKEILPYGFTSGPVYMPNPSVMMRIRPRSDGK
InterPro domains: - IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [27-419]
- IPR001128: Cytochrome P450 (family) [150-391]
- IPR002403: Cytochrome P450, E-class, group IV (family) [264-380]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0044550 (secondary metabolite biosynthetic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Uncharacterized tRNA/rRNA methyltransferase LasT (P37005)
Organism: Escherichia coli (strain K12)
Sequence: MRITIILVAPARAENIGAAARAMKTMGFSDLRIVDSQAHLEPATRWVAHGSGDIIDNIKVFPTLAESLHDVDFTVATTARSRAKYHYYATPVELVPLLEEKSSWMSHAALVFGREDSGLTNEELALADVLTGVPMVADYPSLNLGQAVMVYCYQLATLIQQPAKSDATADQHQLQALRERAMTLLTTLAVADDIKLVDWLQQRLGLLEQRDTAMLHRLLHDIEKNITK
InterPro domains: - IPR029026: tRNA (guanine-N1-)-methyltransferase, N-terminal (homologous_superfamily) [1-177]
- IPR004384: RNA methyltransferase TrmJ/LasT (family) [1-227]
- IPR029028: Alpha/beta knot methyltransferases (homologous_superfamily) [2-156]
- IPR001537: tRNA/rRNA methyltransferase, SpoU type (domain) [3-153]
Interaction partners: - Uncharacterized tRNA/rRNA methyltransferase YfiF
- Uncharacterized tRNA/rRNA methyltransferase YfiF
- tRNA (cytidine(34)-2'-O)-methyltransferase
- tRNA (guanosine(18)-2'-O)-methyltransferase
- Uncharacterized protein YafE
- Uncharacterized protein YbdN
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0140098 (catalytic activity, acting on RNA), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008173 (RNA methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0140101 (catalytic activity, acting on a tRNA), GO:0062105 (RNA 2'-O-methyltransferase activity), GO:0008175 (tRNA methyltransferase activity), GO:0008171 (O-methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0016427 (tRNA (cytosine) methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0032259 (methylation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0001510 (RNA methylation), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0030488 (tRNA methylation), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0006400 (tRNA modification), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0006399 (tRNA metabolic process), GO:0008033 (tRNA processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Leukocyte receptor cluster member 1 (Q96BZ8)
Organism: Homo sapiens (Human)
Sequence: MNILPKKSWHVRNKDNVARVRRDEAQAREEEKERERRVLLAQQEARTEFLRKKARHQNSLPELEAAEAGAPGSGPVDLFRELLEEGKGVIRGNKEYKEEKRQEKERQEKALGILTYLGQSAAEAQTQPPWYQLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRKEKEGSEKQRPKEPPSLDQLRAERLRREAAERSRAEALLARVQGRALQEGQPEEDETDDRRRRYNSQFNPQLARRPRQQDPHLTH
InterPro domains: - IPR039875: Leukocyte receptor cluster member 1-like (family) [1-259]
- IPR019339: CBF1-interacting co-repressor CIR, N-terminal domain (domain) [8-44]
Interaction partners: - Peptidyl-prolyl cis-trans isomerase-like 1
- Pre-mRNA-processing factor 17
- Pre-mRNA-splicing factor SYF2
- Pre-mRNA-splicing factor SLU7
- Tuftelin-interacting protein 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)
Protein: Lipase 8 (Q9P8V9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Secreted lipase that is able to hydrolyze both the neutral triacylglycerols and the monopalmitate ester Tween 40, allowing the use of hydrolyzed products as carbon sources. Acts as an important virulence factor in mouse infection models. Has broad lipolytic activity, which may be important for colonization and subsequent infection, therefore contributing to the persistence and virulence in human tissue (Probable)
Subcellular location: Secreted
Sequence: MLFLLFLLITPIYAGLIFLTKPSNDPFYNPPKGFEKAAVGDILQSRETPKSITGRFAPLEIQNSWQLLVRSEDSFGNPNAIVTTVIQPFNADPSKVASYQVFEDSAKGDCAPSYALQFGSDLSTLATQAETFLLAPLLEQGYYVVSPDYEGPKSTFTIGKQSGQAVLNSIRAALKSGKITNIKDDAKVVMWGYSGGSLASGWAAALQPSYAPELGGNLLGAALGGFVTNITATAQAADGTVFAGIVANALGGVANEYPEFKSILQSDTDKKSVFDEFDSHCLADGVIDYINTSFLTGDNKIFKTGWDILKSSTIAKIVKDNGLVYQKQLVPKIPIFVYHGSIDQIVPIVNVKKTYQNWCEGGISSLEFAEDGTNGHLTETVVGAPAALTWIIDRFNGKQTVSGCQHDKRLSNFQYPNISSSILKYFKVALDTMMSNGLGSDIQKDKITPDDLRKFLLGGW
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [22-399]
- IPR005152: Lipase, secreted (family) [1-441]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0009607 (response to biotic stimulus), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031669 (cellular response to nutrient levels), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: LSM1-LSM7 complex subunit lsm1 (P87173)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex loads onto the 3'-end of single stranded RNA
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, P-body
Sequence: MNQATQIIPFTTSGSLVDYVDRKVIVVLRDGKKLIGILRSFDQFANLMLQYTIERIYVDDMYGDIDRGVYIVRGENVVLLGELDLDKEYDAVKQLRRMPAEELYPLAKLHEEEKKKNIREKGKYLHSVGFSVDGGHDDLY
InterPro domains: - IPR044642: U6 snRNA-associated Sm-like protein Lsm1/8 (family) [12-107]
- IPR034104: Sm-like protein Lsm1 (domain) [10-83]
- IPR001163: Sm domain, eukaryotic/archaea-type (domain) [14-82]
- IPR047575: Sm domain (domain) [11-86]
- IPR010920: LSM domain superfamily (homologous_superfamily) [16-104]
Interaction partners: - LSM complex subunit lsm4
- LSM complex subunit lsm7
- LSM complex subunit lsm2
- Putative ATP-dependent RNA helicase ste13
- LSM complex subunit lsm5
- LSM complex subunit lsm3
- LSM complex subunit lsm6
- Deadenylation-dependent mRNA-decapping factor pdc2
- mRNA decapping complex subunit 2
- mRNA-decapping enzyme subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0000339 (RNA cap binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0022607 (cellular component assembly), GO:0070925 (organelle assembly), GO:0140694 (non-membrane-bounded organelle assembly), GO:0033962 (P-body assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: LETM1 domain-containing protein 1 (Q924L1)
Organism: Mus musculus (Mouse)
Function: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1. May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53
Subcellular location: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus. Mitochondrion inner membrane; Single-pass membrane protein
Sequence: MALSRVCWARAALWGSTVAPGPFVTRRLQLGRSGPAWRAPRSSKLHLSPKADVKNLISYVVTKTRAINGSYHRFLGRHFPRFYALYTTFMKGIQMLWADGKKARRIKADMWKQNLKFHQLSYREMEHLRQFRRDITKCLFVGLISIPPFANYLVFLLMYLFPRQLLVKHFWTPKQQIDFLDVYHGLRRRSHSEVITHLRRASTFVSHEKLRRQLTDLCTKVQSGTHPAAQDVLALRDCFSTYPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRLKSHTTVIHQLDRALAKLGIGQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISCSLKEPELSLLLHNVVLLSTNYLETRR
InterPro domains: - IPR033122: LETM1-like, ribosome-binding domain (domain) [120-360]
- IPR044202: LETM1/MDM38-like (family) [45-356]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: LYR motif-containing protein 2 (Q9NU23)
Organism: Homo sapiens (Human)
Function: Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I
Subcellular location: Mitochondrion
Sequence: MAASRLPPATLTLKQFVRRQQVLLLYRRILQTIRQVPNDSDRKYLKDWAREEFRRNKSATEEDTIRMMITQGNMQLKELEKTLALAKS
InterPro domains: - IPR045293: LYRM2, LYR domain (domain) [17-79]
- IPR008011: Complex 1 LYR protein domain (domain) [20-78]
Interaction partners: - Acyl carrier protein, mitochondrial
- 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
- Electron transfer flavoprotein regulatory factor 1
- LYR motif-containing protein 1
- LYR motif-containing protein 9
- LYR motif-containing protein 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044085 (cellular component biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0098798 (mitochondrial protein-containing complex), GO:0016020 (membrane), GO:0070469 (respirasome), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:0031975 (envelope), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005746 (mitochondrial respirasome), GO:0098803 (respiratory chain complex), GO:0043229 (intracellular organelle), GO:0098800 (inner mitochondrial membrane protein complex), GO:0005739 (mitochondrion), GO:1902495 (transmembrane transporter complex), GO:1990204 (oxidoreductase complex), GO:0030964 (NADH dehydrogenase complex), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0045271 (respiratory chain complex I), GO:0043231 (intracellular membrane-bounded organelle), GO:0005747 (mitochondrial respiratory chain complex I), GO:0019866 (organelle inner membrane), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Trehalose/maltose-binding protein MalE (Q7LYW7)
Organism: Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)
Function: Part of the ABC transporter complex MalEFGK involved in trehalose/maltose import. Binds maltose and trehalose
Subcellular location: Cell membrane; Lipid-anchor
Sequence: MNVKKVLLGLFLVGVLGIAVVASGCIGGQQTSTVTSTPTETSLQGKIVFAVGGAPNEIEYWKGVIAEFEKKYPGVTVELKRQATDTEQRRLDLVNALRGKSSDPDVFLMDVAWLGQFIASGWLEPLDDYVQKDNYDLSVFFQSVINLADKQGGKLYALPVYIDAGLLYYRKDLLEKYGYSKPPETWQELVEMAQKIQSGERETNPNFWGFVWQGKQYESLVCDFVEYVYSNGGSLGEFKDGKWVPTLNKPENVEALQFMVDLIHKYKISPPNTYTEMTEEPVRLMFQQGNAAFERNWPYAWGLHNADDSPVKGKVGVAPLPHFPGHKSAATLGGWHIGISKYSDNKALAWEFVKFVESYSVQKGFAMNLGWNPGRVDVYDDPAVVSKSPHLKELRAVFENAVPRPIVPYYPQLSEIIQKYVNSALAGKISPQEALDKAQKEAEELVKQYS
InterPro domains: - IPR006059: Bacterial-type extracellular solute-binding protein (family) [54-362]
Interaction partners: - Trehalose/maltose transport system permease protein MalF
- Trehalose/maltose transport system permease protein MalG
- Malg sugar transport inner membrane protein
- Malf sugar transport inner membrane protein
- Sugar transporter
- ABC transporter permease
- ABC transporter permease
- Sugar ABC transporter permease
- Trehalose synthase
- HTH-type sugar sensing transcriptional regulator TrmB
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:0030246 (carbohydrate binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0070492 (oligosaccharide binding), GO:1901265 (nucleoside phosphate binding), GO:0046983 (protein dimerization activity), GO:0043168 (anion binding), GO:0042802 (identical protein binding), GO:0000166 (nucleotide binding), GO:0043169 (cation binding), GO:0042803 (protein homodimerization activity), GO:0048030 (disaccharide binding), GO:0046872 (metal ion binding), GO:0017076 (purine nucleotide binding), GO:0002682 (regulation of immune system process), GO:0030554 (adenyl nucleotide binding), GO:0050661 (NADP binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0070887 (cellular response to chemical stimulus), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0071241 (cellular response to inorganic substance), GO:0071248 (cellular response to metal ion), GO:0010039 (response to iron ion), GO:0071281 (cellular response to iron ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:1990204 (oxidoreductase complex), GO:0045254 (pyruvate dehydrogenase complex)