Protein: Metallophosphoesterase 1 (EC 3.1.-.-) (Post-GPI attachment to proteins factor 5) (Q53F39)
Organism: Homo sapiens (Human)
Function: Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19837036}; Multi-pass membrane protein {ECO:0000269|PubMed:19837036}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19837036}; Multi-pass membrane protein {ECO:0000269|PubMed:19837036}. Note=Also localizes to endoplasmic reticulum exit site.
Sequence: MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR
InterPro domains: - IPR004843: Calcineurin-like, phosphoesterase domain (domain) [71-306]
- IPR033308: PGAP5/Cdc1/Ted1 (family) [19-373]
- IPR029052: Metallo-dependent phosphatase-like (homologous_superfamily) [69-349]
- IPR039541: Metallophosphoesterase 1, metallophosphatase domain (domain) [73-329]
Interaction partners: - Cell division cycle protein 27 homolog
- Basic leucine zipper transcriptional factor ATF-like 3
- Chemokine XC receptor 1
- C-type lectin domain family 9 member A
- Guanine nucleotide-binding protein G
- T-cell surface glycoprotein CD8 alpha chain
- Proteasome subunit beta type-5
- Integrin alpha-E
- Thrombomodulin
- Lymphotactin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0046983 (protein dimerization activity), GO:0042802 (identical protein binding), GO:0042803 (protein homodimerization activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0016791 (phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0046907 (intracellular transport), GO:0019538 (protein metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006810 (transport), GO:0044255 (cellular lipid metabolic process), GO:0051649 (establishment of localization in cell), GO:0044249 (cellular biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0043412 (macromolecule modification), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006643 (membrane lipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0016192 (vesicle-mediated transport), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0042157 (lipoprotein metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0048193 (Golgi vesicle transport), GO:0008654 (phospholipid biosynthetic process), GO:0006664 (glycolipid metabolic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0009247 (glycolipid biosynthetic process), GO:0042158 (lipoprotein biosynthetic process), GO:0006506 (GPI anchor biosynthetic process), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0006505 (GPI anchor metabolic process), GO:0046488 (phosphatidylinositol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0012505 (endomembrane system), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)