Protein: Syndecan (E9PBI9)
Organism: Homo sapiens (Human)
Function: Cell surface proteoglycan
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence: MYLDNSSIEEASGVYPIDDDDYASASGSGADEDVESPELTTSRPLPKILLTSAAPKVETTTLNIQNKIPAQTKSPEETDKEKVHLSDSERKMDPAEEDTNVYTEKHSDSLFKRTEVLAAVIAGGVIGFLFAIFLILLLVYRMRKKDEGSYDLGERKPSSAAYQKAPTKEFYA
InterPro domains: - IPR001050: Syndecan (family) [51-172]
- IPR030479: Syndecan, conserved site (conserved_site) [140-150]
- IPR003585: Neurexin/syndecan/glycophorin C (domain) [139-157]
- IPR027789: Syndecan/Neurexin domain (domain) [109-170]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0030165 (PDZ domain binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0002683 (negative regulation of immune system process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0002682 (regulation of immune system process), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0002695 (negative regulation of leukocyte activation), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0050866 (negative regulation of cell activation), GO:0042127 (regulation of cell population proliferation), GO:0007162 (negative regulation of cell adhesion), GO:0008285 (negative regulation of cell population proliferation), GO:0030155 (regulation of cell adhesion), GO:0060627 (regulation of vesicle-mediated transport), GO:0002694 (regulation of leukocyte activation), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0050865 (regulation of cell activation), GO:0044087 (regulation of cellular component biogenesis), GO:1903532 (positive regulation of secretion by cell), GO:1902117 (positive regulation of organelle assembly), GO:0022407 (regulation of cell-cell adhesion), GO:0017157 (regulation of exocytosis), GO:0070664 (negative regulation of leukocyte proliferation), GO:0033043 (regulation of organelle organization), GO:0051046 (regulation of secretion), GO:0051249 (regulation of lymphocyte activation), GO:0022408 (negative regulation of cell-cell adhesion), GO:0070663 (regulation of leukocyte proliferation), GO:0010638 (positive regulation of organelle organization), GO:0045921 (positive regulation of exocytosis), GO:1902115 (regulation of organelle assembly), GO:0051250 (negative regulation of lymphocyte activation), GO:0050670 (regulation of lymphocyte proliferation), GO:0050863 (regulation of T cell activation), GO:0032944 (regulation of mononuclear cell proliferation), GO:0050672 (negative regulation of lymphocyte proliferation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903038 (negative regulation of leukocyte cell-cell adhesion), GO:0050868 (negative regulation of T cell activation), GO:0032945 (negative regulation of mononuclear cell proliferation), GO:0042130 (negative regulation of T cell proliferation), GO:0042129 (regulation of T cell proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0012505 (endomembrane system), GO:0005773 (vacuole), GO:0005794 (Golgi apparatus), GO:0043233 (organelle lumen), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0031012 (extracellular matrix), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0005788 (endoplasmic reticulum lumen), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0062023 (collagen-containing extracellular matrix), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0005796 (Golgi lumen), GO:0005764 (lysosome), GO:0043202 (lysosomal lumen)