Protein: Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) (Q15437)
Organism: Homo sapiens (Human)
Function: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex.
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q15436}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:26522472}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15436}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15436}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15436}.
Sequence: MATYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPLACLLTPLKERPDLPPVQYEPVLCSRPTCKAVLNPLCQVDYRAKLWACNFCFQRNQFPPAYGGISEVNQPAELMPQFSTIEYVIQRGAQSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQDMLGLTKPAMPMQQARPAQPQEHPFASSRFLQPVHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRSWHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLLEMKCCANLTGGYMVMGDSFNTSLFKQTFQRIFTKDFNGDFRMAFGATLDVKTSRELKIAGAIGPCVSLNVKGPCVSENELGVGGTSQWKICGLDPTSTLGIYFEVVNQHNTPIPQGGRGAIQFVTHYQHSSTQRRIRVTTIARNWADVQSQLRHIEAAFDQEAAAVLMARLGVFRAESEEGPDVLRWLDRQLIRLCQKFGQYNKEDPTSFRLSDSFSLYPQFMFHLRRSPFLQVFNNSPDESSYYRHHFARQDLTQSLIMIQPILYSYSFHGPPEPVLLDSSSILADRILLMDTFFQIVIYLGETIAQWRKAGYQDMPEYENFKHLLQAPLDDAQEILQARFPMPRYINTEHGGSQARFLLSKVNPSQTHNNLYAWGQETGAPILTDDVSLQVFMDHLKKLAVSSAC
InterPro domains: - IPR029006: ADF-H/Gelsolin-like domain superfamily (homologous_superfamily) [622-726]
- IPR036180: Gelsolin-like domain superfamily (homologous_superfamily) [623-763]
- IPR037364: Protein transport protein Sec23 (family) [7-763]
- IPR036174: Zinc finger, Sec23/Sec24-type superfamily (homologous_superfamily) [49-123]
- IPR006900: Sec23/Sec24, helical domain (domain) [520-618]
- IPR006895: Zinc finger, Sec23/Sec24-type (domain) [58-98]
- IPR037550: Sec23, C-terminal (domain) [612-732]
- IPR012990: Sec23/Sec24, beta-sandwich (domain) [403-506]
- IPR036175: Sec23/Sec24 helical domain superfamily (homologous_superfamily) [520-622]
- IPR006896: Sec23/Sec24, trunk domain (domain) [127-392]
- IPR007123: Gelsolin-like domain (domain) [634-720]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [128-402]
Interaction partners: - Protein transport protein Sec24A
- Protein transport protein Sec24B
- Small COPII coat GTPase SAR1A
- Protein transport protein Sec16A
- Protein SEC13 homolog
- Protein transport protein Sec24C
- Protein transport protein Sec24D
- Protein transport protein Sec31A
- F-box/WD repeat-containing protein 5
- Protein transport protein Sec31B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006888 (endoplasmic reticulum to Golgi vesicle-mediated transport), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0035459 (vesicle cargo loading), GO:0061024 (membrane organization), GO:0006900 (vesicle budding from membrane), GO:0090114 (COPII-coated vesicle budding), GO:0016050 (vesicle organization), GO:0048193 (Golgi vesicle transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098796 (membrane protein complex), GO:0031984 (organelle subcompartment), GO:0019898 (extrinsic component of membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0070971 (endoplasmic reticulum exit site), GO:0031090 (organelle membrane), GO:0030117 (membrane coat), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0048475 (coated membrane), GO:0030133 (transport vesicle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0030120 (vesicle coat), GO:0030135 (coated vesicle), GO:0005789 (endoplasmic reticulum membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0012507 (ER to Golgi transport vesicle membrane), GO:0030127 (COPII vesicle coat), GO:0030134 (COPII-coated ER to Golgi transport vesicle), GO:0097708 (intracellular vesicle), GO:0030662 (coated vesicle membrane)