Protein: Popeye domain-containing protein 1 (Popeye protein 1) (Blood vessel epicardial substance) (mBVES) (Q9ES83)
Organism: Mus musculus (Mouse)
Function: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.
Subcellular location: Lateral cell membrane {ECO:0000250|UniProtKB:Q8NE79}. Cell junction, tight junction {ECO:0000269|PubMed:16188940}. Membrane {ECO:0000269|PubMed:22354168}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000269|PubMed:24066022}. Membrane, caveola {ECO:0000269|PubMed:24066022}. Note=Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Detected at cell-cell contact but never observed at the free surface of epithelial cells (By similarity). Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle. {ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:20057356}.
Sequence: MNSTESIPLAQSTVAGFTSELESLTPVPSNETTCENWREIHHLVFHVANVCFAVGLLIPTTLHLHMILLRVMLSLGCTLYVVWATLYRCALDVMIWNSVFLGINILHLSYLLYKKRPVKIEKELGGVYHRLFEPLRVPPDLFRRLTGQFCMIQTLKRGQVYATEDKTSVDDRLSILLKGRMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIVADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKVKKLEPQMSLCTQISMLEMRNSITSSSDGEDGLHHFLRGSSSTASLPMSSPQQRASAKMKPIEEGVEDDDEVFVSPDALKVHQLP
InterPro domains: - IPR055272: POPDC1-3 domain (domain) [41-266]
- IPR006916: POPDC1-3 (family) [11-347]
- IPR018490: Cyclic nucleotide-binding domain superfamily (homologous_superfamily) [149-255]
Interaction partners: - Tight junction protein 1
- Rho guanine nucleotide exchange factor 25
- Potassium channel subfamily K member 2
- Protein NDRG4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0030552 (cAMP binding), GO:0030551 (cyclic nucleotide binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0065008 (regulation of biological quality), GO:0097722 (sperm motility), GO:0048870 (cell motility), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0009566 (fertilization), GO:0032504 (multicellular organism reproduction), GO:0007017 (microtubule-based process), GO:0051050 (positive regulation of transport), GO:0048609 (multicellular organismal reproductive process), GO:0040012 (regulation of locomotion), GO:0048522 (positive regulation of cellular process), GO:0007018 (microtubule-based movement), GO:0007276 (gamete generation), GO:0051049 (regulation of transport), GO:2000145 (regulation of cell motility), GO:0006810 (transport), GO:0001539 (cilium or flagellum-dependent cell motility), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0030317 (flagellated sperm motility), GO:0032886 (regulation of microtubule-based process), GO:0051128 (regulation of cellular component organization), GO:0007283 (spermatogenesis), GO:0007338 (single fertilization), GO:1902019 (regulation of cilium-dependent cell motility), GO:0003341 (cilium movement), GO:0003341 (cilium movement), GO:0060632 (regulation of microtubule-based movement), GO:0043269 (regulation of monoatomic ion transport), GO:0048232 (male gamete generation), GO:0060285 (cilium-dependent cell motility), GO:0003352 (regulation of cilium movement), GO:0060295 (regulation of cilium movement involved in cell motility), GO:0060294 (cilium movement involved in cell motility), GO:0010959 (regulation of metal ion transport), GO:0051924 (regulation of calcium ion transport), GO:0003356 (regulation of cilium beat frequency)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)