Protein: Alpha-actinin-like protein 1 (O13728)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11294907}. Note=Localizes to the medial ring in an F-actin-dependent manner.
Sequence: MQANQWQSVQNRTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLEIIGDENLGRYNRNPRMRVHRLENVNKALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFTIADINEEGLTAKEGLLLWCQRKTANYHPEVDVQDFTRSWTNGLAFCALIHQHRPDLLDYNKLDKKNHRANMQLAFDIAQKSIGIPRLIEVEDVCDVDRPDERSIMTYVAEYFHAFSTLDKVETAARRVERFTEVLMSTHDMKIDYESRMKRLLGSIARMQEYWHTVQFENNYTDVKSHSNNFAKFKATEKREWVKEKIDLESLLGTIQTNLKTYQLRKYEPPAGLKIVDLERQWKDFLSEEANQSKLINTHMREIKESMRIAFADRANSFSKMLSTISNEITNLQGDWRDQLDHVEFLQEHLGPLEVELASVKVLYDNCFQAGIEENDYTMFSYEDLEHEFGITANIIANKIKYLENELLEREKRTLSKQELDGITKVFRHFEKKKSNMLNEVEFYAALASLGLVYDTEEGTALFHRAANSEEGVTYERFTEIVMEELEDRDSARQVLYAFCDVADGKSYVTSDDLLRSQVRPNIVKFLECNMNKHSEGLDYLTWIKQLLAEDKEIV
InterPro domains: - IPR036872: CH domain superfamily (homologous_superfamily) [1-234]
- IPR011992: EF-hand domain pair (homologous_superfamily) [481-582]
- IPR014837: EF-hand, Ca insensitive (domain) [554-610]
- IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [86-110]
- IPR001715: Calponin homology domain (domain) [8-230]
Interaction partners: - Actin
- Cofilin
- Tropomyosin
- Myosin type-2 heavy chain 1
- Ras GTPase-activating-like protein rng2
- Cell division control protein 15
- Profilin
- Cell division control protein 12
- Myosin type-2 heavy chain 2
- LIM domain-containing protein C4F6.12
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0030029 (actin filament-based process), GO:0051649 (establishment of localization in cell), GO:0016043 (cellular component organization), GO:0046907 (intracellular transport), GO:0030036 (actin cytoskeleton organization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0007015 (actin filament organization), GO:0007010 (cytoskeleton organization), GO:0006897 (endocytosis), GO:0045010 (actin nucleation), GO:0034314 (Arp2/3 complex-mediated actin nucleation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0005829 (cytosol), GO:0061645 (endocytic patch), GO:0030427 (site of polarized growth), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0051286 (cell tip), GO:0120025 (plasma membrane bounded cell projection), GO:0043332 (mating projection tip), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0030479 (actin cortical patch), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005937 (mating projection), GO:0005856 (cytoskeleton), GO:0030864 (cortical actin cytoskeleton), GO:0015629 (actin cytoskeleton)