Protein: Probable aldehyde oxidase gad-3 (EC 1.2.3.1) (Q960A1)
Organism: Caenorhabditis elegans
Function: May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1.
Sequence: MPLTGIFFNVNGKDVNEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVLGTWDDCQNKAVYRAVNACLVPLFHVHKTFVITVEGVGSRDKIHPIQDRMARGHALQCGFCSPGFVMSAYALFSNQPNPTIQQINAAIRANLCRCTGYRPILEALYSFSSESGGCCGGNKTGGGCCKDKSSSDEDGGYDEKLLSFNDFPKYDPTQEIIFPPSLRVFSDSETPVTLKGDRIELLLPKNIDQFKKFKKDRTVISSGLITRFVSTRNPKEFSQKWISTKYVKEFNEITVNKDSVVVGAALNIQKMADTLTSSLSINIGKEIDSFIQKFSSPQIANFATWTGAIISGAKSSLSVSDLLILFNVLDAKLTLLNNSGELTQVAIEEFAEKKLFATHTIVNAIFSRSLTGFLFCLKLGETSEQDSTNFNFAALVGNQVSRIFVGLGGQPKRLTSLEVHIDALKGLSVSDLCQTTEMSDYKNVKIALTRFSDFMNHKEKTEEIEGINYLQYFKPKTNESAGRPIANYFNERAITGEAFYVNDIQAYNAVHLGFVLSTVPHAEITKIDVSEALQLEGVAGYFGVSDVPGNNTPGLQISNMNFPDDTTIFADKKVESVGQVIGVIAANDVVLARRAAKLVKVEYKELPSLVNFKEAIEAKSLLGDVQHFGKDENLVKESLENSSKVLEGECDIGGQEHYYLETQSSLVIPGEGDELIVNCSTQGTSFTQLMVAETMKIPAHKIIVKTKRLGGGFGGKVNNASWIACMCAIVAKKLNRPTYGFLSRADDLAITGKRHEVHAKYRVGINFDGKIEGIHYQAWLNGGWSKDHSEGVTMVMGLMVDDVYNMGTIRFDGYPVKTNSNSNTALRGYGNPQSKLINEGVMRRIARDVGKSTEEIKRINFALEGGRRYLGGKIHNDALVECWEYCKKWSEFENRQSGIKQFNKNSTAVKRGIAMSSVRFGLPHPGPTGHGIASLLINLDGSVQLSIGGTEMGQGLNQKMLQVCSEALKRPIDTITIVDCSTDKVTNAPETGGSQNADTNGLAVLACCKKIMSRLQPIIDKNDGEWEKSIREAYGAYVPLQCTEYGTVERAKFGVGEMESPYNTTGACAVEMEIDTLTGYNRVIRVDIVMDVGESLNPALDIGQIEGAFIQGYGLVTCEKITFNKTTGQLDQNTAGKYKIPKASDVPKDFRVKLLGINNANGAQVYSSKGIGEPPLMMSCGAVHSSIMNCIDNWRNENGIHEFVDTISPLSAEKIQELCSKK
InterPro domains: - IPR046867: Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain (domain) [921-1182]
- IPR036010: 2Fe-2S ferredoxin-like superfamily (homologous_superfamily) [6-91]
- IPR002888: [2Fe-2S]-binding (domain) [87-159]
- IPR001041: 2Fe-2S ferredoxin-type iron-sulfur binding domain (domain) [6-77]
- IPR036318: FAD-binding, type PCMH-like superfamily (homologous_superfamily) [194-400]
- IPR002346: Molybdopterin dehydrogenase, FAD-binding (domain) [239-397]
- IPR036856: Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily (homologous_superfamily) [511-656]
- IPR016166: FAD-binding domain, PCMH-type (domain) [229-459]
- IPR037165: Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily (homologous_superfamily) [642-1256]
- IPR000674: Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead (domain) [530-642]
- IPR006058: 2Fe-2S ferredoxin, iron-sulphur binding site (binding_site) [43-51]
- IPR016169: FAD-binding, type PCMH, subdomain 2 (homologous_superfamily) [281-401]
- IPR036884: [2Fe-2S]-binding domain superfamily (homologous_superfamily) [98-215]
- IPR016208: Aldehyde oxidase/xanthine dehydrogenase-like (family) [3-1257]
- IPR008274: Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain (domain) [670-896]
- IPR012675: Beta-grasp domain superfamily (homologous_superfamily) [3-94]
Interaction partners: - Nicotinamide N-methyltransferase
- Nicotinamide N-methyltransferase-like
- UDP-glucuronosyltransferase
- sulfite oxidase
- Molybdenum cofactor sulfurase
- Alcohol dehydrogenase class-3
- Putative UDP-glucuronosyltransferase ugt-46
- UDP-glucuronosyltransferase
- UDP-glucuronosyltransferase
- Putative UDP-glucuronosyltransferase ugt-48
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016903 (oxidoreductase activity, acting on the aldehyde or oxo group of donors), GO:0016623 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0009653 (anatomical structure morphogenesis), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0030703 (eggshell formation), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0007292 (female gamete generation), GO:0048477 (oogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)