Protein: HSPA8 protein (Q96IS6)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: AMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
InterPro domains: - IPR029048: Heat shock protein 70kD, C-terminal domain superfamily (homologous_superfamily) [473-587]
- IPR013126: Heat shock protein 70 family (family) [2-553]
- IPR018181: Heat shock protein 70, conserved site (conserved_site) [138-289]
- IPR029047: Heat shock protein 70kD, peptide-binding domain superfamily (homologous_superfamily) [324-484]
- IPR043129: ATPase, nucleotide binding domain (homologous_superfamily) [2-323]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0140657 (ATP-dependent activity), GO:0140104 (molecular carrier activity), GO:0140776 (protein-containing complex destabilizing activity), GO:0036094 (small molecule binding), GO:0030674 (protein-macromolecule adaptor activity), GO:0097159 (organic cyclic compound binding), GO:0016887 (ATP hydrolysis activity), GO:1901363 (heterocyclic compound binding), GO:0016787 (hydrolase activity), GO:0140597 (protein carrier chaperone), GO:0044877 (protein-containing complex binding), GO:0043167 (ion binding), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0023023 (MHC protein complex binding), GO:1901265 (nucleoside phosphate binding), GO:0051087 (chaperone binding), GO:0043168 (anion binding), GO:0050839 (cell adhesion molecule binding), GO:0003676 (nucleic acid binding), GO:0031072 (heat shock protein binding), GO:0005102 (signaling receptor binding), GO:0051082 (unfolded protein binding), GO:0000166 (nucleotide binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0032553 (ribonucleotide binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0001664 (G protein-coupled receptor binding), GO:0017076 (purine nucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0045296 (cadherin binding), GO:0003723 (RNA binding), GO:0032555 (purine ribonucleotide binding), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0005524 (ATP binding), GO:0031625 (ubiquitin protein ligase binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding), GO:0017111 (ribonucleoside triphosphate phosphatase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0051641 (cellular localization), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0061919 (process utilizing autophagic mechanism), GO:0048523 (negative regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006457 (protein folding), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:0044248 (cellular catabolic process), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0009725 (response to hormone), GO:1901135 (carbohydrate derivative metabolic process), GO:0045184 (establishment of protein localization), GO:0006914 (autophagy), GO:0044087 (regulation of cellular component biogenesis), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0046907 (intracellular transport), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0031668 (cellular response to extracellular stimulus), GO:0051128 (regulation of cellular component organization), GO:1901575 (organic substance catabolic process), GO:0071496 (cellular response to external stimulus), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0060341 (regulation of cellular localization), GO:0019637 (organophosphate metabolic process), GO:0019538 (protein metabolic process), GO:0051649 (establishment of localization in cell), GO:0034641 (cellular nitrogen compound metabolic process), GO:0031647 (regulation of protein stability), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0009991 (response to extracellular stimulus), GO:0042594 (response to starvation), GO:0006139 (nucleobase-containing compound metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0042026 (protein refolding), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0080090 (regulation of primary metabolic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0030163 (protein catabolic process), GO:0070201 (regulation of establishment of protein localization), GO:0048545 (response to steroid hormone), GO:0071702 (organic substance transport), GO:0072521 (purine-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:1902903 (regulation of supramolecular fiber organization), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0015031 (protein transport), GO:0031667 (response to nutrient levels), GO:0019693 (ribose phosphate metabolic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0061024 (membrane organization), GO:0006753 (nucleoside phosphate metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0071310 (cellular response to organic substance), GO:0009267 (cellular response to starvation), GO:0072594 (establishment of protein localization to organelle), GO:0006796 (phosphate-containing compound metabolic process), GO:0032880 (regulation of protein localization), GO:1902904 (negative regulation of supramolecular fiber organization), GO:0032870 (cellular response to hormone stimulus), GO:0033993 (response to lipid), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0014070 (response to organic cyclic compound), GO:0008104 (protein localization), GO:0007034 (vacuolar transport), GO:0051253 (negative regulation of RNA metabolic process), GO:0031669 (cellular response to nutrient levels), GO:0072666 (establishment of protein localization to vacuole), GO:0009117 (nucleotide metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0006605 (protein targeting), GO:0007041 (lysosomal transport), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0009141 (nucleoside triphosphate metabolic process), GO:0033365 (protein localization to organelle), GO:0006355 (regulation of DNA-templated transcription), GO:0071407 (cellular response to organic cyclic compound), GO:0071396 (cellular response to lipid), GO:0071383 (cellular response to steroid hormone stimulus), GO:0006163 (purine nucleotide metabolic process), GO:0006623 (protein targeting to vacuole), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0045892 (negative regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0072665 (protein localization to vacuole), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0006622 (protein targeting to lysosome), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0061462 (protein localization to lysosome), GO:0046034 (ATP metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0098552 (side of membrane), GO:1990904 (ribonucleoprotein complex), GO:0030054 (cell junction), GO:0140535 (intracellular protein-containing complex), GO:0072562 (blood microparticle), GO:0000974 (Prp19 complex), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0071944 (cell periphery), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0098576 (lumenal side of membrane), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0101031 (chaperone complex), GO:0031090 (organelle membrane), GO:0030141 (secretory granule), GO:0043230 (extracellular organelle), GO:0005773 (vacuole), GO:0005681 (spliceosomal complex), GO:0043233 (organelle lumen), GO:0070062 (extracellular exosome), GO:0060205 (cytoplasmic vesicle lumen), GO:0000323 (lytic vacuole), GO:0031983 (vesicle lumen), GO:0099503 (secretory vesicle), GO:0070013 (intracellular organelle lumen), GO:0030659 (cytoplasmic vesicle membrane), GO:0030055 (cell-substrate junction), GO:0101002 (ficolin-1-rich granule), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0034774 (secretory granule lumen), GO:0012506 (vesicle membrane), GO:0065010 (extracellular membrane-bounded organelle), GO:0030135 (coated vesicle), GO:0005774 (vacuolar membrane), GO:0005775 (vacuolar lumen), GO:0031982 (vesicle), GO:0005925 (focal adhesion), GO:1903561 (extracellular vesicle), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0098852 (lytic vacuole membrane), GO:0043202 (lysosomal lumen), GO:1904813 (ficolin-1-rich granule lumen), GO:0005764 (lysosome), GO:0097708 (intracellular vesicle), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0030665 (clathrin-coated vesicle membrane), GO:0005765 (lysosomal membrane)