Protein: Genome polyprotein (P27913)
Organism: Dengue virus type 1 (strain Jamaica/CV1636/1977) (DENV-1)
Function: [Capsid protein C]: Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle. During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions. Overcomes the anti-viral effects of host EXOC1 by sequestering and degrading the latter through the proteasome degradation pathway
Subcellular location: [Capsid protein C]: Virion. Host nucleus. Host cytoplasm. Host cytoplasm, host perinuclear region
Sequence: MNNQRKKTGRPSFNMLKRARNRVSTGSQLAKRFSKGLLSGQGPMKLVMAFIAFLRFLAIPPTAGILARWSSFKKNGAIKVLRGFKKEISSMLNIMNRRKRSVTMLLMLLPTALAFHLTTRGGEPTLIVSKQERGKSLLFKTSAGVNMCTLIAMDLGELCEDTMTYKCPRITERQPDDVDCWCNATDTWVTYGTCSQTGEHRRDKRSVALAPHVGLGLETRTETWMSSEGAWKQIQKVETWALRHPGFTVIGLFLAHAIGTSITQKGIIFILLMLVTPSMAMRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKNKPTLDIELLKTEVTNPAVLRKLCIEAKISNTTTDSRCPTQGEATLVEEQDANFVCRRTFVDRGWGNGCGLFGKGSFLTCAKFKCVTKLEGKIVQYENLKYSVIVTVHTGDQHQVGNETTEHGTIATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNRVVLLTMKKKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVIDKEKPVNIEAEPPFGESYIVVGSGEKALKLSWFKKGSSIGKMFEATARGARRMAILGDTAWDFGSIGGVFTSVGKLIHQIFGTAYGILFSGVSWTMKIGIGILLTWLGLNSRSTSLSMTCIAVGMVTLYLGVMVQADSGCVINWKGKELKCG
InterPro domains: - IPR000336: Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily (homologous_superfamily) [575-678]
- IPR013755: Flaviviral glycoprotein E, central domain, subdomain 1 (homologous_superfamily) [344-535]
- IPR027287: Glycoprotein E, immunoglobulin-like domain, flavivirus (domain) [578-674]
- IPR000069: Envelope glycoprotein M, flavivirus (domain) [207-280]
- IPR038345: Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily (homologous_superfamily) [679-775]
- IPR013756: Flaviviral glycoprotein E, central domain, subdomain 2 (homologous_superfamily) [332-550]
- IPR011998: Envelope glycoprotein E, central and dimerisation domain, flavivirus (domain) [282-576]
- IPR026470: Flavivirus envelope glycoprotein E, Stem/Anchor domain (domain) [676-775]
- IPR038302: Envelope glycoprotein M superfamily, flavivirus (homologous_superfamily) [206-280]
- IPR038688: Flavivirus polyprotein propeptide superfamily (homologous_superfamily) [115-195]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [569-680]
- IPR036253: Flavivirus glycoprotein, central and dimerisation domain superfamily (homologous_superfamily) [281-577]
- IPR037172: Flavivirus capsid protein C superfamily (homologous_superfamily) [21-100]
- IPR001122: Capsid protein C, flavivirus (domain) [6-113]
- IPR038055: Flaviviral glycoprotein E, dimerisation domain (homologous_superfamily) [283-574]
- IPR002535: Flavivirus polyprotein propeptide (domain) [120-204]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0016032 (viral process), GO:0046755 (viral budding), GO:0019068 (virion assembly), GO:0019058 (viral life cycle)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0033643 (host cell part), GO:0043657 (host cell), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0039713 (viral factory), GO:0033655 (host cell cytoplasm part), GO:0039714 (cytoplasmic viral factory), GO:0030430 (host cell cytoplasm)