Protein: Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (Q80XU8)
Organism: Mus musculus (Mouse)
Function: Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery.
Subcellular location: Membrane {ECO:0000269|PubMed:16828986, ECO:0000269|PubMed:18227064}; Single-pass type I membrane protein {ECO:0000269|PubMed:16828986, ECO:0000269|PubMed:18227064}.
Sequence: MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARSFGDLESLRSLHLDGNRLVELGSSSLRGPVNLQHLILSGNQLGRIAPGAFDDFLDSLEDLDVSYNNLRQVPWAGIGSMPALHTLNLDHNLIDALPPGVFAQLSQLSRLDLTSNRLATLAPDPLFSRGRDAEASPSPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPTLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPVPTMHWVGPDDRLVGNSSRAWAFPNGTLEIGVTGAGDAGAYTCIATNPAGEATARVELRVLALPHGGNTSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGLVSWGLGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPATPLCHALQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGTSPMPKSHPPRSPPPRPQRSCSLDLGDTGGCYGYARRLGGAWARRSHSVHGGLLGAGCRGVGGSAERLEESVV
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [14-276]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [409-480]
- IPR050467: Leucine-rich repeat and fibronectin type-III domain-containing (family) [7-616]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [279-372]
- IPR003961: Fibronectin type III (domain) [405-502]
- IPR013098: Immunoglobulin I-set (domain) [283-368]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [277-492]
- IPR007110: Immunoglobulin-like domain (domain) [281-367]
- IPR003598: Immunoglobulin subtype 2 (domain) [293-358]
- IPR003591: Leucine-rich repeat, typical subtype (repeat) [71-215]
- IPR000483: Cysteine-rich flanking region, C-terminal (domain) [234-279]
- IPR003599: Immunoglobulin domain subtype (domain) [287-369]
- IPR001611: Leucine-rich repeat (repeat) [51-205]
Interaction partners: - Receptor-type tyrosine-protein phosphatase S
- Disks large homolog 4
- Interleukin-1 receptor accessory protein-like 1
- Receptor-type tyrosine-protein phosphatase F
- Disks large homolog 1
- Interleukin-1 receptor accessory protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0065008 (regulation of biological quality), GO:0023051 (regulation of signaling), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0001505 (regulation of neurotransmitter levels), GO:0060627 (regulation of vesicle-mediated transport), GO:1903530 (regulation of secretion by cell), GO:0099177 (regulation of trans-synaptic signaling), GO:0051049 (regulation of transport), GO:0010646 (regulation of cell communication), GO:0017157 (regulation of exocytosis), GO:0051588 (regulation of neurotransmitter transport), GO:0051046 (regulation of secretion), GO:0046928 (regulation of neurotransmitter secretion), GO:0050804 (modulation of chemical synaptic transmission), GO:1903305 (regulation of regulated secretory pathway), GO:2000300 (regulation of synaptic vesicle exocytosis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)