Protein: Multifunctional fusion protein [Includes: Interleukin-1; Interleukin-1 beta] (O43645)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm, cytosol {ECO:0000256|RuleBase:RU364119}. Secreted {ECO:0000256|RuleBase:RU364119}. Lysosome {ECO:0000256|ARBA:ARBA00004371, ECO:0000256|RuleBase:RU364119}. Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550, ECO:0000256|RuleBase:RU364119}. Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10. {ECO:0000256|RuleBase:RU364119}.
Sequence: APVRSLYCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
InterPro domains: - IPR020877: Interleukin-1 conserved site (conserved_site) [112-132]
- IPR008996: Cytokine IL1/FGF (homologous_superfamily) [6-150]
- IPR000975: Interleukin-1 family (family) [3-150]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0005515 (protein binding), GO:0140678 (molecular function inhibitor activity), GO:0030547 (signaling receptor inhibitor activity), GO:0005102 (signaling receptor binding), GO:0019838 (growth factor binding), GO:0019955 (cytokine binding), GO:0005126 (cytokine receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0006955 (immune response), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0048585 (negative regulation of response to stimulus), GO:0009892 (negative regulation of metabolic process), GO:0060759 (regulation of response to cytokine stimulus), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0043207 (response to external biotic stimulus), GO:0010646 (regulation of cell communication), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006959 (humoral immune response), GO:0009966 (regulation of signal transduction), GO:0006952 (defense response), GO:0060255 (regulation of macromolecule metabolic process), GO:0001818 (negative regulation of cytokine production), GO:0060761 (negative regulation of response to cytokine stimulus), GO:0001817 (regulation of cytokine production), GO:0009620 (response to fungus), GO:0098542 (defense response to other organism), GO:0019730 (antimicrobial humoral response), GO:0001959 (regulation of cytokine-mediated signaling pathway), GO:0050832 (defense response to fungus), GO:0032649 (regulation of type II interferon production), GO:0001960 (negative regulation of cytokine-mediated signaling pathway), GO:0032689 (negative regulation of type II interferon production), GO:0010629 (negative regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0032660 (regulation of interleukin-17 production)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)