Protein: Insulin receptor (IR) (EC 2.7.10.1) (XTK-1b) (Xe-InsR) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] (Q9PVZ4)
Organism: Xenopus laevis (African clawed frog)
Function: Receptor tyrosine kinase which mediates actions of insulin. May be required for forelimb regeneration.
Subcellular location: Cell membrane {ECO:0000269|PubMed:1648732, ECO:0000269|PubMed:7595277}; Single-pass type I membrane protein {ECO:0000269|PubMed:1648732, ECO:0000269|PubMed:7595277}.
Sequence: MGQGVLRGEGHPNNNPNSKVGWKSLVGIITIFMLILCDQSDGKICYSMDIRNNISQFSMLEDCTVIEGHLQILLMFTSKPENFRGLRFPKLTTITDYLLLFRVYGLESLKDLFPNLTVIRGTRLFFNYALVIFEMVHXKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDNKEECGDVCPGTVKGKSKCKHTLVNGALVERCWTQDHCQKVCPSDCKGSGCLPDGQCCHPECLGSCRKPNDPSECTACRHFQNEGVCVTACPKGSYQFQGWRCIDFNTCQELNSRCQNSRDNSCPPYVIHKGECMPDCPSGYIANSTTRTCTPCAGPCPKVCTIFQNVKTIDSVTSAQELRGCTVINGSLIINLRGGNNIATELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGEVLEAGNYSFYALDNPSLRQLWDWHKHNLTIIHGKLFFHHNPRLCLSQIHQMEEVTGTKGRQDKNDIATKTNGDQASCEDNLLTFNFIKTSHDMVLLRWDAYWPPDYRDLLGFMVHYKEAPFQNVTEFDGQDACGSNSWTVVDMDAPERSADGKTQSPGCLLRSLKPWTQYAVFVKTLVSGSDEGRTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPPSEPNGNVTHYLVYWQEQPEDSDLYEVDYCNKGLKLPSRTWTPPTEIDENGNENQTEHTSVNKCCPCPKTEFQIQKEQDESAFRKTFENYLHNEVFIPRPVRKRRDLFGVANGTLPDPVTAPPLFNVSSTRAPDEPEPKIYSQKVWFKESVLISGLKHFTGYRIEIHACNHELSMGCSVAAYVNARTMPEATADKVVGPITYEYVEPNIIHLKWQEPKDPNGLIVLYEVHYSRVGGIEEVITCVSQKQYNTDKGGKLRVLTPGNYSVKIRATSLAGNGSWTEQAYFQVPDHPHSNIVKIITGPIIAVFLLLIVLVYCVVQKKKDAEGPAGPLYTSSNPEYLSASEVYIPDEWEVPRDKINLLRELGQGSFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNEASVMKAFNCHHVVRLLGVVSKGQPTLVIMELMAHGDLKSYLRSLRPDAENNPGRLAPTLKEIIQMAAEISDGMAYLNAKKFVHRDLAARNCMVADDYAVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTAFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSLDHPENCPPRLHSLMQMCWQYNPKMRPTFLEIIDMLKDDLRPSFQDVSFYYSDENKPPETDDLEIDFENMESTPLDPSSCSLRDQSSRTNIYEEHIPYTHMNGGRKNGRILSLPRSSPS
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [986-1279]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [505-943]
- IPR050122: Receptor Tyrosine Kinase (family) [132-1284]
- IPR003961: Fibronectin type III (domain) [506-944]
- IPR016246: Tyrosine-protein kinase, insulin-like receptor (family) [14-1362]
- IPR036941: Receptor L-domain superfamily (homologous_superfamily) [39-513]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [514-949]
- IPR006211: Furin-like cysteine-rich domain (domain) [190-350]
- IPR000494: Receptor L-domain (domain) [62-481]
- IPR006212: Furin-like repeat (repeat) [241-331]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [1013-1279]
- IPR017441: Protein kinase, ATP binding site (binding_site) [1018-1046]
- IPR000719: Protein kinase domain (domain) [1012-1287]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [215-345]
- IPR008266: Tyrosine-protein kinase, active site (active_site) [1144-1156]
- IPR020635: Tyrosine-protein kinase, catalytic domain (domain) [1012-1279]
- IPR040969: Insulin receptor, trans-membrane domain (domain) [938-981]
- IPR002011: Tyrosine-protein kinase, receptor class II, conserved site (conserved_site) [1172-1180]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0005520 (insulin-like growth factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0044237 (cellular metabolic process), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0021700 (developmental maturation), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0019538 (protein metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0009994 (oocyte differentiation), GO:0001556 (oocyte maturation), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0071695 (anatomical structure maturation), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:0006796 (phosphate-containing compound metabolic process), GO:0016310 (phosphorylation), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation), GO:0048009 (insulin-like growth factor receptor signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)