wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Aftiphilin b (Aftiphilin isoform X1) (F1QB98)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Sequence: MEPDVVRLYSSSPPPLDETGEEEEEDEFGEFGGFDGGGVSSSFSLSELDTPTTYDQSNALEDSPPDLIIKCTQNIIVSENNGWTNEKERETESISSFGIAEKESSGILTNGMTSSDLQVELSDRSDQNSPSMGSDVQNSSTGDEHSLSNGYSESCSNSDLDQSLHNCLQSTHIEVNYGRDASIADVLDRSRITDKLPDSNNHSSCTEACELRDTEAGLEICGNSQFLSSCRDAQEVEGEQDQSENCFAADCLDESMDHVDKAEAETVSSVDADLISDMQLSGDTIEIHGSFANSEVGIDAEVETSADPTADEDFCDFRDATQGFTDFSRTESMTQEGLPEFVTAMSRCSTDDDFGDTDTLKDFKEEDELAEEMTGEEGGFCSELPPSDSFADFSSAPFEGAAGGEDDGWAAFAPRESPKGDQDSWATFGEEQSTYAGKEEQDVETSSAPSREDIQSSTVDFSCKIQHLFKTAFPLDVHAEVSEVTEVLPLHKFLPAQDPQEQRDPSSSFFAQENALVMWRHLQDILGSHGLKFKWAGSHSNRILLNCLGIRNILFTGDKNQPLIVPMFAAGLGMLEPTKESQKSPASPALCPSAPLESGNILCTQVAPSLAISIDAQDEGISKLNLDYFGPVDECSSDSETDTPLPGVDPEIYELTTAKMENNTTGRNIADAFTKLMESIEKTKPTVRKPETDEEMSEEAAKVISLLPDLSFMKARVLMFPSILTPAANHT
InterPro domains: - IPR029205: Aftiphilin, clathrin-binding box (domain) [517-585]
- IPR046359: Aftiphilin-like (family) [1-727]
Interaction partners: - Synergin, gamma.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0030276 (clathrin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0009887 (animal organ morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0022008 (neurogenesis), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0007423 (sensory organ development), GO:0042461 (photoreceptor cell development), GO:0046530 (photoreceptor cell differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0048699 (generation of neurons), GO:0001754 (eye photoreceptor cell differentiation), GO:0042462 (eye photoreceptor cell development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: BSD domain-containing protein C22A12.14c (O13905)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000269|PubMed:16823372}.
Sequence: MDLYDYMAPTTTTEEDDEEGYEKLKEEMGSALNNLTNGKFGLFWNSMKEKSENFLDDTKGKASSGMQQLKSQLEENIPVNSAMENLRKVEETAGSFWSGFGSTVNGFLDQALQISPKEDDVSTPTHEASSSVFLNRHERQLLELVQNENTFTQIISEPSHGITFESWEKEISIDGKTEEISLLLEEYPDLRKQMESLVPSEVSYDDFWKRFFWHKEVVQPIKAIQSGNDEEEIFSWGDERSDEEESDNEQVNDEKKQSSEEDTTENNSAAEVIDETVNDLESAVSKGLQIETQPASHDGEVDGEVKEEEENKVSSSSNIEASQSSLEVKDEANRKVDDDDEDDDDWE
InterPro domains: - IPR005607: BSD domain (domain) [167-219]
- IPR051494: BSD domain-containing protein (family) [14-340]
- IPR035925: BSD domain superfamily (homologous_superfamily) [130-228]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Uncharacterized protein (Q38AV4)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MDGGFPWTKHVEWNRFRNLGEGVGGFKGFRCCGGGQMRGLCGTELSVCCDCCLAVNESVHNRLAVGLKRATPEPLWQPTRLTSPYCILCANGLRDDFYTSCMSWGRESVALSLGEKVLLFKSSSPRESAVSLNLSGEACGYSESISSVAVSQFSDSHCFLGGVNGAVGLYESHGGGELSLSSSFEMPPPLFGGDLASEAAFSGATTSIRCLSTTNVHPWVVAAGTAAHGLFVLDSRFTTPAARMCGSDLWNSVDCRHSQRPLYPSEAISLLSSLNGICGVSWNSSGSLVATGESGGLVNIWSLSNTRSPVQRIRLPSAHTTVKAVAFHPTNPYELVLGGAADDGCVRVYDVSSATPHYKWGVSTGCQVTQALYSPDGSFIVSAHGARLKASVAIDAASAQSHATRAGVSRTDSGGGGWGAGDELQWLTEKFERAMKCSENAAESSIDTCLGFNRASSSGLNEAKPLLSEAPPFSLVMWRKGTQHQGTTPMSFTHGSGIHHQCAAGSPSRRCEPLPLVSMYTMMGHRSRPLQLAVPFSQTADQGCIASIAGGADCTIRFWKCFYSRSEMVNWGQRVCASLRTAITEEDVEEMTAMPLR
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [68-409]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [140-561]
- IPR001680: WD40 repeat (repeat) [131-560]
- IPR033010: WD repeat Cdc20/Fizzy (family) [82-566]
Interaction partners: - Cdc23 domain-containing protein
- Cell division cycle protein 16, putative
- Anaphase-promoting complex subunit 2
- Cyclosome subunit 1, putative
- Anaphase-promoting complex subunit 11
- Rev7, putative
- Uncharacterized protein
- Anaphase-promoting complex subunit 10
- Dynein heavy chain region D6 P-loop domain-containing protein
- Ubiquitin-conjugating enzyme E2, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044248 (cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Transcription factor (Myb domain protein 43) (Putative transcription factor) (Q9SPG7)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MGRQPCCDKVGLKKGPWTIEEDKKLINFILTNGHCCWRALPKLSGLLRCGKSCRLRWINYLRPDLKRGLLSEYEEQKVINLHAQLGNRWSKIASHLPGRTDNEIKNHWNTHIKKKLRKMGIDPLTHKPLSEQEASQQAQGRKKSLVPHDDKNPKQDQQTKDEQEQHQLEQALEKNNTSVSGDGFCIDEVPLLNPHEILIDISSSHHHHSNDDNVNINTSKFTSPSSSSSSTSSCISSVVPGDEFSKFFDEMEILDLKWLSSDDSLGDDISKDGKFNNSTVDTMNLWDINDLSSLDMFMNEHDDGFIGNGNGCSRMVLDQDSWTFDLL
InterPro domains: - IPR017930: Myb domain (domain) [9-116]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [11-108]
- IPR001005: SANT/Myb domain (domain) [9-114]
- IPR015495: Myb transcription factor, plants (family) [1-246]
Interaction partners: - NAC domain-containing protein 12
- NAC domain-containing protein 10
- NAC domain-containing protein 73
- Homeobox protein knotted-1-like 7
- NAC domain-containing protein 43
- NAC domain-containing protein 66
- NAC domain-containing protein 7
- NAC domain-containing protein 104
- NAC domain-containing protein 30
- NAC domain-containing protein 37
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0003700 (DNA-binding transcription factor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0042221 (response to chemical), GO:0070887 (cellular response to chemical stimulus), GO:0046685 (response to arsenic-containing substance), GO:0071243 (cellular response to arsenic-containing substance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: At1g67410 (Exostosin family protein) (Glycosyltransferase) (Q08AA5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323}.
Sequence: MYGKTICTIVFFIFLVASFSIYMGTVDPRPYFYLLQSQPNGASSPCSSSGKPLRVFMYDLPRKFNIAMMDPHSSDVEPITGKNLPSWPQTSGIKRQHSVEYWLMASLLNGGEDENEAIRVFDPDLADVFYVPFFSSLSFNTHGKNMTDPDTEFDRLLQVELMEFLENSKYWNRSGGKDHVIPMTHPNAFRFLRQQVNASILIVVDFGRYSKDMARLSKDVVSPYVHVVESLNEEGDDGMGDPFEARTTLLYFRGNTVRKDEGKIRLRLEKLLAGNSDVHFEKSVATTQNIKVSTEGMRSSKFCLHPAGDTPSSCRLFDAIVSHCIPVIISDKIELPFEDEIDYSEFSLFFSIKESLEPGYILNNLRQFPKEKWLEMWKRLKNVSHHFEFQYPPKREDAVNMLWRQVKHKIPYVKLAVHRNRRLKVPDWWL
InterPro domains: - IPR040911: Exostosin, GT47 domain (domain) [51-365]
- IPR004263: Exostosin-like (family) [50-405]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0010393 (galacturonan metabolic process), GO:0000271 (polysaccharide biosynthetic process), GO:0045488 (pectin metabolic process), GO:0045489 (pectin biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0098791 (Golgi apparatus subcompartment), GO:0031985 (Golgi cisterna), GO:0043231 (intracellular membrane-bounded organelle), GO:0005795 (Golgi stack), GO:0031982 (vesicle), GO:0005802 (trans-Golgi network), GO:0000138 (Golgi trans cisterna), GO:0097708 (intracellular vesicle)
Protein: Conserved domain protein (Q726V4)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Not known
Sequence: MEIRDMSTNDDIRLLLCDPATLGEMTADGVHGRFALAGCVHNPDMFGAVEAAPGLYLLPETGWREGAALCVGEARPVGDDAGLGTTVSATQKGALRHRLEGAPCWKGKGYLLFFDTANDYRIIFPRPTREKLAEHYRAFESSPSLRNFNFEYHAFVLCRAIGRETLDGLDVLDVASGNGSFLSVLRGKGAHVTGFEPSESECREAAKSGLELINAPFTPAMLPEGRQYDVVIAGNIFEHVPDPVPFMERIRARLKPGGWLFFQIPNDFNAIQMKYLERSGSDAWFVAPPDHLNYWDVPQARRFVDAQGFDVVHEEAQFPIEMFLLMGMDYRKQPELGRQAHLMRCAFEDSFADDMGTLSRFYASLIGGGFGRDYVAVLRKRP
InterPro domains: - IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [129-344]
Interaction partners: - Conserved domain protein
- Capsule polysaccharide biosynthesis protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0019538 (protein metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0006412 (translation), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006518 (peptide metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0010467 (gene expression), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901659 (glycosyl compound biosynthetic process), GO:0043043 (peptide biosynthetic process), GO:0006414 (translational elongation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: NGG1 interacting factor 3-like (Q384V6)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MTSLISRVARVMEEIAPLHLADRSWDNVGVLVESPMSNNSGVVVLTIDLTPEVMEECLRHNAEVIIAYHPPIFTPFKRLTLTDPKQKIILQTIRHGASIYSPHTSLDAVSGGINDWLASIVDARGRCYPIRPCEIYMQDKNCGKVDATVGIGRIVSLSGPKEIHTLVQDIKQGLGLPTVRVSLPSCWTGNTPVERVAICAGSGGSVFSGLKEHVDVLLAGEMGHHEVLAANAKGQAVILCEHSNTERGYLSSELLPKLKKAMGEEVSVITSTVDKDPLVVW
InterPro domains: - IPR036069: DUF34/NIF3 superfamily (homologous_superfamily) [5-280]
- IPR002678: DUF34/NIF3 (family) [5-281]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0033554 (cellular response to stress), GO:0034605 (cellular response to heat)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: LysM domain-containing GPI-anchored protein 3 (Q6NPN4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Required as a cell surface receptor for peptidoglycan (PGN) elicitor signaling leading to innate immunity. Plays an essential role in detecting PGNs and restricting bacterial growth (of Pseudomonas syringae pv. tomato DC3000 for example).
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Sequence: MKNPEKPLLLFLILASSLASMATAKSTIEPCSSKDTCNSLLGYTLYTDLKVTEVASLFQVDPVSMLLSNSIDISYPDVENHVLPAKLFLKIPITCSCVDGIRKSLSTHYKTRTSDTLGSIADSVYGGLVSPEQIQVANSETDLSVLDVGTKLVIPLPCACFNGTDESLPALYLSYVVRGIDTMAGIAKRFSTSVTDLTNVNAMGAPDINPGDILAVPLLACSSNFPKYATDYGLIIPNGSYALTAGHCVQCSCVLGSRSMYCEPASISVSCSSMRCRNSNFMLGNITSQQSSSGCKLTTCSYNGFASGTILTTLSMSLQPRCPGPQQLAPLIAPPDNVPKELMYLPSPSPSPSPEFDDIAGGGSSIAAVPAASPGGATVSSSNSIPGNPANGPGGSISIASCPLSYYSFIALLIPIGSCFFVF
InterPro domains: - IPR036779: LysM domain superfamily (homologous_superfamily) [107-224]
- IPR018392: LysM domain (domain) [107-217]
Interaction partners: - Chitin elicitor receptor kinase 1
- Protein LYK5
- LysM domain receptor-like kinase 3
- LRR receptor-like serine/threonine-protein kinase EFR
- Protein LYK2
- Leucine-rich repeat receptor-like protein kinase PEPR1
- Receptor like protein 23
- Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
- BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
- Receptor-like protein 30
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0005539 (glycosaminoglycan binding), GO:0042834 (peptidoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0006955 (immune response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Metabotropic glutamate receptor 2 (Q80T43)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
Sequence: DAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVA
InterPro domains: - IPR000337: GPCR, family 3 (family) [9-94]
- IPR050726: Metabotropic Glutamate Receptor (family) [5-174]
- IPR017979: GPCR, family 3, conserved site (conserved_site) [21-39]
- IPR001828: Receptor, ligand binding region (domain) [6-169]
- IPR028082: Periplasmic binding protein-like I (homologous_superfamily) [6-171]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0043168 (anion binding), GO:0043177 (organic acid binding), GO:0031406 (carboxylic acid binding), GO:0016597 (amino acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0050877 (nervous system process), GO:0007600 (sensory perception), GO:0007606 (sensory perception of chemical stimulus), GO:0050909 (sensory perception of taste)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Protocadherin alpha-8 (PCDH-alpha-8) (Q9Y5H6)
Organism: Homo sapiens (Human)
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Sequence: MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVDVEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFMLDVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAPTFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTALRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDLGSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [15-768]
- IPR002126: Cadherin-like (domain) [28-678]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [800-933]
- IPR013164: Cadherin, N-terminal (domain) [30-111]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [30-668]
- IPR020894: Cadherin conserved site (conserved_site) [230-563]
Interaction partners: - Protocadherin alpha-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007155 (cell adhesion), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)