Protein: T-cell-specific surface glycoprotein CD28 (CD antigen CD28) (P31041)
Organism: Mus musculus (Mouse)
Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27460989}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P10747}.
Sequence: MTLRLLFLALNFFSVQVTENKILVKQSPLLVVDSNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRSNAEFNCDGDFDNETVTFRLWNLHVNHTDIYFCKIEFMYPPPYLDNERSNGTIIHIKEKHLCHTQSSPKLFWALVVVAGVLFCYGLLVTVALCVIWTNSRRNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP
InterPro domains: - IPR008093: T cell antigen CD28 (family) [126-217]
- IPR013106: Immunoglobulin V-set domain (domain) [26-123]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [22-137]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [19-146]
- IPR040216: Cytotoxic T-lymphocyte protein 4/CD28 (family) [3-214]
Interaction partners: - T-lymphocyte activation antigen CD80
- T-lymphocyte activation antigen CD86
- Tumor necrosis factor receptor superfamily member 5
- Protein kinase C theta type
- ICOS ligand
- CD40 ligand
- Cytotoxic T-lymphocyte protein 4
- Growth factor receptor-bound protein 2
- Inducible T-cell costimulator
- Phosphatidylinositol 3-kinase regulatory subunit alpha
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0031294 (lymphocyte costimulation), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0048522 (positive regulation of cellular process), GO:0002696 (positive regulation of leukocyte activation), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0050865 (regulation of cell activation), GO:0046649 (lymphocyte activation), GO:0050867 (positive regulation of cell activation), GO:0031295 (T cell costimulation), GO:0051251 (positive regulation of lymphocyte activation), GO:0022409 (positive regulation of cell-cell adhesion), GO:0022407 (regulation of cell-cell adhesion), GO:0042110 (T cell activation), GO:0051249 (regulation of lymphocyte activation), GO:0050870 (positive regulation of T cell activation), GO:0050863 (regulation of T cell activation), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0009897 (external side of plasma membrane), GO:0005886 (plasma membrane)