Protein: Rho-type GTPase-activating protein 2 (Q06407)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: GTPase-activating protein (GAP) for CDC42 and/or RHO1.
Sequence: MSADPINDQSSLCVRCNKSIASSQVYELESKKWHDQCFTCYKCDKKLNADSDFLVLDIGTLICYDCSDKCTNCGDKIDDTAIILPSSNEAYCSNCFRCCRCSNRIKNLKYAKTKRGLCCMDCHEKLLRKKQLLLENQTKNSSKEDFPIKLPERSVKRPLSPTRINGKSDVSTNNTAISKNLVSSNEDQQLTPQVLVSQERDESSLNDNNDNDNSKDREETSSHARTVSIDDILNSTLEHDSNSIEEQSLVDNEDYINKMGEDVTYRLLKPQRANRDSIVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEIIVNTPRNSTDKITSPLNSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVEMKTSTSSSTLRLSDNGSFSRPQTADNLLPHKKVAPSPNKKLSRSFSLKSKNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNIRKSKAKKNPVSRGQSDSTIYNTLPQHGNFTVPEFNHKKAQSSLGSISKKQNSNDTATNRRINGSFTSSSSGHHIAMFRTPPLESGPLFKRPSLSSESAHHRSSSLQTSRSTNALLEDDSTKVDATDESATSLEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQSASSRESLEQKENIATSITVKSPSSNSDRKGSISNASPKPRFWKIFSSAKDHQVGDLESQQRSPNSSSGGTTNIAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQNNSLHSDTLSPKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDGEKDIVDMKERNYIVEFILGNYRDIFKQA
InterPro domains: - IPR000198: Rho GTPase-activating protein domain (domain) [788-1006]
- IPR008936: Rho GTPase activation protein (homologous_superfamily) [756-1009]
- IPR001781: Zinc finger, LIM-type (domain) [11-125]
- IPR050729: Rho GTPase-activating protein (family) [88-1008]
Interaction partners: - Cell division control protein 42
- Cell division control protein 24
- Rho-type GTPase-activating protein 1
- Bud emergence protein 1
- Dual specificity protein kinase YAK1
- Serine/threonine-protein kinase CLA4
- Serine/threonine-protein kinase STE20
- Ras-related protein RSR1
- GTP-binding protein RHO1
- GTP-binding protein RHO4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0008047 (enzyme activator activity), GO:0060589 (nucleoside-triphosphatase regulator activity), GO:0030695 (GTPase regulator activity), GO:0005096 (GTPase activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0040007 (growth), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0042221 (response to chemical), GO:0032505 (reproduction of a single-celled organism), GO:0007163 (establishment or maintenance of cell polarity), GO:0022402 (cell cycle process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0045927 (positive regulation of growth), GO:0019954 (asexual reproduction), GO:0031139 (positive regulation of conjugation with cellular fusion), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0031137 (regulation of conjugation with cellular fusion), GO:0065009 (regulation of molecular function), GO:0030029 (actin filament-based process), GO:0007117 (budding cell bud growth), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040008 (regulation of growth), GO:0048522 (positive regulation of cellular process), GO:0007114 (cell budding), GO:0032005 (signal transduction involved in positive regulation of conjugation with cellular fusion), GO:0050790 (regulation of catalytic activity), GO:0000910 (cytokinesis), GO:0044093 (positive regulation of molecular function), GO:0030010 (establishment of cell polarity), GO:1903047 (mitotic cell cycle process), GO:0001558 (regulation of cell growth), GO:0010570 (regulation of filamentous growth), GO:0030307 (positive regulation of cell growth), GO:0030036 (actin cytoskeleton organization), GO:0010033 (response to organic substance), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0070887 (cellular response to chemical stimulus), GO:0016043 (cellular component organization), GO:0090033 (positive regulation of filamentous growth), GO:0051128 (regulation of cellular component organization), GO:0000278 (mitotic cell cycle), GO:2000220 (regulation of pseudohyphal growth), GO:0000282 (cellular bud site selection), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0000750 (pheromone-dependent signal transduction involved in conjugation with cellular fusion), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:0019236 (response to pheromone), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0070783 (growth of unicellular organism as a thread of attached cells), GO:0000749 (response to pheromone triggering conjugation with cellular fusion), GO:0043085 (positive regulation of catalytic activity), GO:0006996 (organelle organization), GO:0097435 (supramolecular fiber organization), GO:0000281 (mitotic cytokinesis), GO:0007015 (actin filament organization), GO:0070784 (regulation of growth of unicellular organism as a thread of attached cells), GO:0071444 (cellular response to pheromone), GO:0070786 (positive regulation of growth of unicellular organism as a thread of attached cells), GO:0007010 (cytoskeleton organization), GO:0043087 (regulation of GTPase activity), GO:0051345 (positive regulation of hydrolase activity), GO:0036267 (invasive filamentous growth), GO:0032185 (septin cytoskeleton organization), GO:0043547 (positive regulation of GTPase activity), GO:0001403 (invasive growth in response to glucose limitation), GO:0031106 (septin ring organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032161 (cleavage apparatus septin structure), GO:0032153 (cell division site), GO:0000399 (cellular bud neck septin structure), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0043229 (intracellular organelle), GO:0005935 (cellular bud neck), GO:0005938 (cell cortex), GO:0005618 (cell wall), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009277 (fungal-type cell wall), GO:0005856 (cytoskeleton), GO:0032156 (septin cytoskeleton)