Protein: Alkylglycerol monooxygenase (Q8BS35)
Organism: Mus musculus (Mouse)
Function: Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MRSPGAQDNVSVSQGMRAMFYMMEPSETAFQTVEEVPDYVKKATPFFIFLILLELVISWILKGKPSGRLDDALTSISAGVVSRLPSLFFRSLEVTSYIYIWENYRLLELPWDSTWTWYFTFLGVDFGYYWFHRMAHEINIFWAAHQAHHSSEDYNLSTALRQSVLQQYSSWVFYCPLALFIPPSVFAVHIQFNLLYQFWIHTEIIRTLGPLEVILNTPSHHRVHHGRNRYCIDKNYAGTLIIWDRIFGTFEAENEQVIYGLTHPIGTFEPFNVQFHHLLYIWTTFWTTPGFCHKFSVLFKGPGWGPGKPRLGLSEEIPEVTGQEVPFSSSASQLLKIYTVLQFAVMLAFYEETFANTAVLSQVTLLLRIFFFILTLTSIGFLLDQRSKAATMETFRCLLFLTLHRFGHLKPLIPSLSFAFEIFFSVCIAFWGVRSITQLTSGSWKKP
InterPro domains: - IPR056853: Alkylglycerol monooxygenase, C-terminal (domain) [335-422]
- IPR006694: Fatty acid hydroxylase (domain) [118-249]
- IPR051689: Sterol desaturase/TMEM195-like (family) [7-445]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016714 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0018904 (ether metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006629 (lipid metabolic process), GO:0006662 (glycerol ether metabolic process), GO:0006638 (neutral lipid metabolic process), GO:0046460 (neutral lipid biosynthetic process), GO:0046486 (glycerolipid metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0046485 (ether lipid metabolic process), GO:0006643 (membrane lipid metabolic process), GO:0046463 (acylglycerol biosynthetic process), GO:0006639 (acylglycerol metabolic process), GO:0006641 (triglyceride metabolic process), GO:0019432 (triglyceride biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031984 (organelle subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)