Protein: Runt-related transcription factor (Q8UVG3)
Organism: Gallus gallus (Chicken)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009374}.
Sequence: MASNSLFSSVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSEVSPVVVAQQQQQQQQQQQQEAAVPRLRPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVLTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFPERLSDLGRIPHPSMRVGVPTQSPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRLSGASELGPFSDPRQFTSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQNQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQSDGVEADGSHSSSPTVLNSSGRMDESVWRPY
InterPro domains: - IPR013711: Runx, C-terminal domain (domain) [381-472]
- IPR008967: p53-like transcription factor, DNA-binding domain superfamily (homologous_superfamily) [77-202]
- IPR013524: Runt domain (domain) [74-203]
- IPR000040: Acute myeloid leukemia 1 protein (AML1)/Runt (family) [1-472]
- IPR016554: Runt-related transcription factor RUNX (family) [1-472]
- IPR012346: p53/RUNT-type transcription factor, DNA-binding domain superfamily (homologous_superfamily) [72-213]
- IPR027384: Runx, central domain superfamily (homologous_superfamily) [330-368]
Interaction partners: - Transcription factor SOX-9
- Core-binding factor subunit beta
- Bone morphogenetic protein 2
- Osteopontin
- Collagen alpha-1
- Indian hedgehog protein
- Collagen alpha-1
- Aggrecan core protein
- ZnMc domain-containing protein.
- Collagen alpha-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:1901363 (heterocyclic compound binding), GO:0097159 (organic cyclic compound binding), GO:0003676 (nucleic acid binding), GO:0001067 (transcription regulatory region nucleic acid binding), GO:0003677 (DNA binding), GO:0003690 (double-stranded DNA binding), GO:0043565 (sequence-specific DNA binding), GO:0000976 (transcription cis-regulatory region binding), GO:1990837 (sequence-specific double-stranded DNA binding), GO:0000987 (cis-regulatory region sequence-specific DNA binding), GO:0000977 (RNA polymerase II transcription regulatory region sequence-specific DNA binding), GO:0000978 (RNA polymerase II cis-regulatory region sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0001503 (ossification), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0048871 (multicellular organismal-level homeostasis), GO:0048522 (positive regulation of cellular process), GO:0045597 (positive regulation of cell differentiation), GO:0009887 (animal organ morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0009888 (tissue development), GO:0030154 (cell differentiation), GO:0001649 (osteoblast differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0045595 (regulation of cell differentiation), GO:0001894 (tissue homeostasis), GO:0061036 (positive regulation of cartilage development), GO:0060249 (anatomical structure homeostasis), GO:0051216 (cartilage development), GO:0061035 (regulation of cartilage development), GO:0003007 (heart morphogenesis), GO:0032332 (positive regulation of chondrocyte differentiation), GO:0001501 (skeletal system development), GO:0072359 (circulatory system development), GO:0061448 (connective tissue development), GO:0032330 (regulation of chondrocyte differentiation), GO:0060485 (mesenchyme development), GO:0048762 (mesenchymal cell differentiation), GO:0007507 (heart development), GO:0060317 (cardiac epithelial to mesenchymal transition), GO:0001837 (epithelial to mesenchymal transition)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)