Protein: Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) (Gex-3-interacting protein 8) (Prion-like-(Q/N-rich) domain-bearing protein 12) (P34333)
Organism: Caenorhabditis elegans
Function: Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MESFKELAREYDEKFKAFQDDLQKWEETSERKEYAEFHRVQAESEFPELKREREDRERWARAERIRGEDEKSMLAKEHADKKIRLGVAKIPRLLTESERKMDEFVERPGSILKDMKKEHRQSVLDRLEEWSPEERSLFKSRQADHVKIFHGLTEFFVDKTASDLVLFYYMNKKTEDYKKDFKPKKRVTKYKVGAFPSVEELAYFRMMPPLDFSSFPKNSLMCYFCCRTVNGIDLNGTFMPKEAYEIFAICPDEDRVVCSGCREEAAKLYKDNRCFGNRCSNQKKRANRVNRNIPLDFADFPVRTRAFIMDKLGSTRVAVKFCTPCKNALTRWINDVNNKEETIMAELLNYEGQVGWTDDEKTKLVTLINSSPTLDWVSISEGMNRRPNECKMQYDAMNGVKTQPMIEEVDEEDGNGQEEGGDALVNTPTTSSAAARRSGLARNAKKPVRTPRAPRSAGGRRTGGAVTRAQAVPKPVEDLGEEIDEMEIEDNDEDASRGSRGKDSKAPSDRDGSPADMEGDSPEGQDQDADQDQDQDQDVDEEEEEVIVRDIDSPVKTLLSPKILSGGHKPDFPPVPRIQKPSTSSQPPPPEPMDTKENESDDGEEDNDILEIDVDEPPAKRPTPTSSSSHLIGSSSVGGSERELGGRGLVQQQQQQQPQAQSAAPPVTVSTAAAATAERLVNATSPSPSVASQHLVPTETSTSVPPVTIVPPAIQQPVVVISGAAPQFTQQQTTHSPALIAQPIPQQLIPQRVSTPAQILTPTPVRPTAASTPSMDQFLGLFKQQQQQQQQQPQQSNLMQQLGNINPQFLALLLQQQQQQQQVQQAQVQAAQTQGSLTSGTPFQAQQRPDEALQKLFSSPEMLGTLLNAKYQFPQFPQAIQQNPLLMNAQHQLILQQQQLAMQHAQAQAAQAAQAQAAQAAQAQAQAQAEAKLKTQAAQAKAQADAQARVQTQQQAHLKAQAQAQYQMNRPQLIPASVQMPIGINTAYHQKSLTPSETSASATPPAHRPRAATTVGSKMPAGRSNVQEAELRTLKEELIKRIRLFRDRIAEDAHLKREEENIVTYTAQIQASRVQYNTEILGQMKQRYEQAAARRIEIVKELDEPAKFINGVQNKFNDFSVFKLDEIDRQTLHEILQRYAAEQKPDQLQQQQNDFHNLLRQNNIGIRQAQYPALQASPHQAAIIQHQQQQEAFKKLQQQHQDAQKRKLEAPVSSATPQVKRIALSQSSPVQRFSQHPNGTLPHNLAVVYQNKMPQDREKLLQEQQLNQYLFAAQQQHLQQQQQHHGTQPEQKSKRKSGIESITSMQGAPHRHIQLAGPSSSRIQSGRGVSPALSASRSVAPTISGAAGRSITAGTSGHSSTSDYNKELAERMNEVFKPTHPQLLQTKASAMNSNAVSPANTNNSDEIECVYQGPPKTPASIKRLQPTEGPRTLSGQRMKSILSVPAHQRRSSIPPVKTEDEAMECLSMMMYEEAKAPPSDRIVTKLISSSEAAAAANPSAKFSYLDIFNDVVKRDEERCQRMLQSTSVLQPSRELDAFLQQLQQNPQQYANLSAAEKLALQQYQIHSAHQKSQQQAQLQAAQQLQQQQQARPDHYEKFHLLRPNAEIVRPIPTTFSHFLNKATTSTVSSSASAPQFLQPPAAASIAAPTPISTPHAMPSPSVGVQTAPPTPQAVHHPVMPIIPGKPSSVNSNVSDVSSDDDDVRNPEKLPANRLPPLPGDKTAFRSVIDLRATGHVAVTKKIPVKYPLVVQAQNGIQPIKDYGPPCKNLVYEDLSDDE
InterPro domains: - IPR051571: Nuclear receptor corepressor (family) [78-702]
- IPR001005: SANT/Myb domain (domain) [126-400]
- IPR017884: SANT domain (domain) [125-176]
Interaction partners: - Transcription initiation factor TFIID subunit 12
- Transcription initiation factor TFIID subunit 9
- Uncharacterized protein
- Transcription initiation factor TFIID subunit 5
- Transcription initiation factor TFIID subunit 10
- SANT domain-containing protein
- Transcription-associated protein 1
- histone acetyltransferase
- Uncharacterized protein B0353.1
- Putative histone deacetylase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008134 (transcription factor binding), GO:0140297 (DNA-binding transcription factor binding), GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0040013 (negative regulation of locomotion), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0032504 (multicellular organism reproduction), GO:0045927 (positive regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0003006 (developmental process involved in reproduction), GO:0048523 (negative regulation of cellular process), GO:0048609 (multicellular organismal reproductive process), GO:0040008 (regulation of growth), GO:0040012 (regulation of locomotion), GO:0009892 (negative regulation of metabolic process), GO:0009791 (post-embryonic development), GO:0035262 (gonad morphogenesis), GO:0048639 (positive regulation of developmental growth), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0048580 (regulation of post-embryonic development), GO:2000026 (regulation of multicellular organismal development), GO:2000145 (regulation of cell motility), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0048608 (reproductive structure development), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0090598 (male anatomical structure morphogenesis), GO:0048581 (negative regulation of post-embryonic development), GO:0061062 (regulation of nematode larval development), GO:0061458 (reproductive system development), GO:0061064 (negative regulation of nematode larval development), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0040027 (negative regulation of vulval development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0030334 (regulation of cell migration), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:0030336 (negative regulation of cell migration), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0006357 (regulation of transcription by RNA polymerase II), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription), GO:0000122 (negative regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)