Protein: Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin) (P08032)
Organism: Mus musculus (Mouse)
Function: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
Sequence: METPKETAVESSGPKVLETAEEIQHRRAEVLNQYQRFKDRVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEIAKDKTYEPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKQLRLLWDLLLELTQEKSDVLLRALKFYQYSQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTARKGKVDRVNQYANECAQEKHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQWMEEKEPQLTSEDYGKDLVSSEALFHNHKRLERNLAVMDDKVKELCAKADKLMISHSADAPQIQQMKLDLVSNWERIRALATNRYAKLKASYGYHRFLSDYDELSGWMKEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQSADATGQELLDGNHEASEEIREKMTILANDWAALLELWDKCQHQYRQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDDDYKDVQNLKSRVQKQQDFEEELAVNEIMLNNLEKTGQEMIEDGHYASEAVAARLSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVEWQVTSEDYGKGLADVQNLLRKHGLLESDVTARQNQVDTLTDMAAHFEEIGHPDSGDIRARQESLLSRFEALKEPLAIRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQVITERGNKMVEEGHFAAEDIASRVESLNKNMESLHARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFENSIKALRDQAEVCQQQQAAPVDEAGREARVIALYDFEARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFVPAVYVRKLAPDELPGFPQHRQEEPVNIPQLQQQVETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKTENTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEELLTPEGAHIRQELNTRWNSLKRLADEQYQLLSSAHAVEMFHREADDVKEQIDKKCRALNAADPGSDLLSVQALQRQHEVFERDIIPLGEKVTTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKASDLENWIKTIGGVISSPELAEDLTGTEILLERHQEHHDDIKREDPTFQALEDFGTELIDSGHRNRREIDNTLQNINSKRDNLEKSWENRKKMLDQCLELQLFRGKCDQVESWMVARENSLRSDDRDHLNSLQALMKKRDDLDKAITAQEGKISDLENVATRLIDNDHYAKEEIAARLQRVLDRWKALKEQLLTELGKLGDYADLKQFYRDLEDLEEWINEMLPIACDESYKDPTNIQRKYLKHQAFENEVNGRAEQVDGVINLGNSLIERRVCDGDEENMQEQLDKLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNDLAQELISSGTFNIDQIEEKMNGVNERFENVQSLAAAHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDYGRDLQSVQNLLKKHKRLEGELVAHEPAVQNVLDTAESLRDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLEYLQFMENAEEEEAWLGEKCALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILNKEETQNKDKISTKIQVLNEKTASLAKALAAWKSQLDDVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKHDTLDASLQSFQQERLSEIAELKDQLVAGEHSQAKAIEEQHAALLRHWEQLLEASRVHRQKLLEKQLPLQKAEELFMEFAHKASAFNNWCENAEEDLSEPVHCVSLNEIRQLQKEHEAFLASLAGAQEDFNYLLELDKQIKALNVPSSPYTWLTVDVLGRIWNHLPDIIKEREQELQKEEARQIKNFEMCQEFEQNASAFLQWIQETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRHLTKIEDLGDSMEEALILDIKYSTIGLAQQWDQLHQLGMRMQHNLEQQIQAKDTIGVSEETLKEFSTTYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEGEPEPKFEKFLNAVDPGRKGYVSLEDYTSFLIDKESENIKTSDDIESAFQALAEGKAYITKEDMKQALTPEQVSFCTIHMQQYMDPRGRSQPAGYDYVGFTNSFFGN
InterPro domains: - IPR036028: SH3-like domain superfamily (homologous_superfamily) [978-1059]
- IPR001452: SH3 domain (domain) [975-1034]
- IPR018159: Spectrin/alpha-actinin (repeat) [53-2256]
- IPR011992: EF-hand domain pair (homologous_superfamily) [2264-2380]
- IPR002048: EF-hand domain (domain) [2267-2345]
- IPR014837: EF-hand, Ca insensitive (domain) [2346-2414]
- IPR002017: Spectrin repeat (repeat) [52-2254]
Interaction partners: - Spectrin beta chain, erythrocytic
- Spectrin beta chain
- Caspase-3
- Spectrin beta chain
- Spectrin alpha chain, non-erythrocytic 1
- Ankyrin-1
- Ammonium transporter Rh type A
- Band 3 anion transport protein
- Spectrin beta, non-erythrocytic 5
- Spectrin beta chain, non-erythrocytic 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0030507 (spectrin binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0030029 (actin filament-based process), GO:0051094 (positive regulation of developmental process), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0045597 (positive regulation of cell differentiation), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051130 (positive regulation of cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0061061 (muscle structure development), GO:0009888 (tissue development), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0010927 (cellular component assembly involved in morphogenesis), GO:0055006 (cardiac cell development), GO:0055001 (muscle cell development), GO:0032956 (regulation of actin cytoskeleton organization), GO:0051147 (regulation of muscle cell differentiation), GO:0030239 (myofibril assembly), GO:0022607 (cellular component assembly), GO:0051149 (positive regulation of muscle cell differentiation), GO:1902903 (regulation of supramolecular fiber organization), GO:0042692 (muscle cell differentiation), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0072359 (circulatory system development), GO:0060537 (muscle tissue development), GO:0033043 (regulation of organelle organization), GO:0006996 (organelle organization), GO:0010638 (positive regulation of organelle organization), GO:0035051 (cardiocyte differentiation), GO:0097435 (supramolecular fiber organization), GO:0007507 (heart development), GO:0070925 (organelle assembly), GO:0060297 (regulation of sarcomere organization), GO:0051493 (regulation of cytoskeleton organization), GO:0014706 (striated muscle tissue development), GO:0048738 (cardiac muscle tissue development), GO:0051153 (regulation of striated muscle cell differentiation), GO:0055013 (cardiac muscle cell development), GO:0051155 (positive regulation of striated muscle cell differentiation), GO:0007010 (cytoskeleton organization), GO:0110020 (regulation of actomyosin structure organization), GO:0055007 (cardiac muscle cell differentiation), GO:0051146 (striated muscle cell differentiation), GO:0055003 (cardiac myofibril assembly), GO:0055002 (striated muscle cell development), GO:0051495 (positive regulation of cytoskeleton organization), GO:0140694 (non-membrane-bounded organelle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0071944 (cell periphery), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0098562 (cytoplasmic side of membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0005886 (plasma membrane), GO:0009898 (cytoplasmic side of plasma membrane), GO:0043005 (neuron projection), GO:0030424 (axon)