Protein: DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] (Q99LZ3)
Organism: Mus musculus (Mouse)
Function: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Subcellular location: Nucleus {ECO:0000269|PubMed:16338220}. Chromosome {ECO:0000250|UniProtKB:Q7ZT48}. Cytoplasm {ECO:0000269|PubMed:16338220}.
Sequence: MTEVLDLHGQDSDGGSEEMVLTPAELIEKLEQAWMNEKFAPELLESKAEIVECVMEQLEHMEENLRRAKKGDLKVSIHRMEMERIRYVLSSYLRCRLMKIEKFFPHILEKEKVRSEGEPSSLSPEEFVFAKEYMDHTETHFKNVALKHMPPNLQKVDLLRAVPKPDLDSYVFLRVKERQENILVEPEADEQRDYVIDLEVGSQHLIRYKTIAPLVASGAVQLI
InterPro domains: - IPR038749: GINS complex protein Sld5, alpha-helical domain (domain) [26-146]
- IPR008591: GINS complex subunit Sld5 (family) [1-223]
- IPR021151: GINS subunit, domain A (domain) [72-144]
- IPR031633: DNA replication complex GINS protein SLD5, C-terminal (domain) [165-223]
- IPR036224: GINS, helical bundle-like domain superfamily (homologous_superfamily) [21-163]
Interaction partners: - DNA replication complex GINS protein PSF2
- Cell division control protein 45 homolog
- DNA replication complex GINS protein PSF3
- DNA replication licensing factor MCM4
- DNA replication complex GINS protein PSF1
- DNA replication licensing factor MCM3
- DNA replication licensing factor MCM7
- DNA replication licensing factor MCM5
- DNA replication licensing factor MCM6
- DNA replication licensing factor MCM2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0048589 (developmental growth), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0008283 (cell population proliferation), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0001824 (blastocyst development), GO:0009790 (embryo development), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0001832 (blastocyst growth), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0009792 (embryo development ending in birth or egg hatching), GO:0043009 (chordate embryonic development), GO:0006260 (DNA replication), GO:0001701 (in utero embryonic development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)