Protein: Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2) (Q99665)
Organism: Homo sapiens (Human)
Function: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence: MAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [124-616]
- IPR003961: Fibronectin type III (domain) [124-620]
- IPR052672: Type I Cytokine Receptor Family, Type 2 Subfamily (family) [124-678]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [120-614]
- IPR010457: Immunoglobulin C2-set-like, ligand-binding (domain) [28-118]
- IPR003529: Long hematopoietin receptor, Gp130 family 2, conserved site (conserved_site) [401-458]
Interaction partners: - Interleukin-12 receptor subunit beta-1
- Tyrosine-protein kinase JAK2
- Signal transducer and activator of transcription 4
- Interleukin-27 receptor subunit alpha
- Non-receptor tyrosine-protein kinase TYK2
- Interleukin-12 subunit alpha
- Interleukin-12 subunit beta
- Interferon gamma
- Interleukin-6
- Interleukin-10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0042221 (response to chemical), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002684 (positive regulation of immune system process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002682 (regulation of immune system process), GO:0002253 (activation of immune response), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0002764 (immune response-regulating signaling pathway), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0002697 (regulation of immune effector process), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0007166 (cell surface receptor signaling pathway), GO:0031349 (positive regulation of defense response), GO:0001817 (regulation of cytokine production), GO:0010033 (response to organic substance), GO:0002218 (activation of innate immune response), GO:0031347 (regulation of defense response), GO:0034097 (response to cytokine), GO:0045089 (positive regulation of innate immune response), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0002758 (innate immune response-activating signaling pathway), GO:0045088 (regulation of innate immune response), GO:0071310 (cellular response to organic substance), GO:0010468 (regulation of gene expression), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0002221 (pattern recognition receptor signaling pathway), GO:0002752 (cell surface pattern recognition receptor signaling pathway), GO:0140895 (cell surface toll-like receptor signaling pathway), GO:0034142 (toll-like receptor 4 signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)