Protein: Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (P46660)
Organism: Mus musculus (Mouse)
Function: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks.
Sequence: MSFGSEHYLCSASSYRKVFGDSSRLSARLSGPGGSGSFRSQSLSRSNVASTAACSSASSLGLGLAYRRLPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRELRAQLEEASSARAQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVAVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLESDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTGGLSISGLNPLPNPSYLLPPRILSSTASKVSSAGLSLKKEEEEEEEEASKEVSKKTSKVGEGFEETLGEAVISTKKTGKSATEESTSSSQKM
InterPro domains: - IPR050405: Intermediate filament structural protein (family) [5-477]
- IPR006821: Intermediate filament head, DNA-binding domain (domain) [11-92]
- IPR018039: Intermediate filament protein, conserved site (conserved_site) [393-401]
- IPR039008: Intermediate filament, rod domain (domain) [93-407]
Interaction partners: - Neurofilament light polypeptide
- Neurofilament heavy polypeptide
- Neurofilament medium polypeptide
- Gigaxonin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:0005200 (structural constituent of cytoskeleton), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048857 (neural nucleus development), GO:0030901 (midbrain development), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0021762 (substantia nigra development), GO:0007420 (brain development), GO:0007417 (central nervous system development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0098793 (presynapse), GO:0030054 (cell junction), GO:0043209 (myelin sheath), GO:0099080 (supramolecular complex), GO:0098794 (postsynapse), GO:0005737 (cytoplasm), GO:0099571 (postsynaptic cytoskeleton), GO:0099569 (presynaptic cytoskeleton), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0099081 (supramolecular polymer), GO:0099572 (postsynaptic specialization), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0014069 (postsynaptic density), GO:0031594 (neuromuscular junction), GO:0043005 (neuron projection), GO:0098984 (neuron to neuron synapse), GO:0099512 (supramolecular fiber), GO:0099513 (polymeric cytoskeletal fiber), GO:0032279 (asymmetric synapse), GO:0005856 (cytoskeleton), GO:0030424 (axon), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton)