Protein: Small ribosomal subunit protein uS4 (Q6P5M3)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Sequence: MPVAKTWVCSKTYVTPRRPFEKSRLDQELRLIGEYGLRNKREVWRVKFTLAKIRKAARELLTLDEKDPKRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKVEDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFVVRLDSQKHIDFSLRSPYGGGRPGRVKRKNAKKAQGGGGGGDDEEED
InterPro domains: - IPR001912: Small ribosomal subunit protein uS4, N-terminal (domain) [3-107]
- IPR018079: Small ribosomal subunit protein uS4, conserved site (conserved_site) [106-130]
- IPR005710: Small ribosomal subunit protein uS4, eukaryota/archaea (family) [8-165]
- IPR036986: RNA-binding S4 domain superfamily (homologous_superfamily) [107-164]
- IPR022801: Small ribosomal subunit protein uS4 (family) [12-180]
- IPR002942: RNA-binding S4 domain (domain) [108-179]
Interaction partners: - Large ribosomal subunit protein P1
- Small ribosomal subunit protein uS8
- Small ribosomal subunit protein uS9
- Ribosomal protein L15
- Large ribosomal subunit protein eL22
- Large ribosomal subunit protein eL20
- Ubiquitin-ribosomal protein eL40 fusion protein
- 40S ribosomal protein S12
- Large ribosomal subunit protein uL11
- Large ribosomal subunit protein eL24
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0009059 (macromolecule biosynthetic process), GO:0043604 (amide biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0006518 (peptide metabolic process), GO:0010467 (gene expression), GO:0043043 (peptide biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)