Protein: Solute carrier family 26 member 6 (G3XAC1)
Organism: Homo sapiens (Human)
Subcellular location: Membrane; Multi- pass membrane protein
Sequence: MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSRHISVVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
InterPro domains: - IPR036513: STAS domain superfamily (homologous_superfamily) [403-637]
- IPR002645: STAS domain (domain) [423-634]
- IPR011547: SLC26A/SulP transporter domain (domain) [143-373]
- IPR001902: SLC26A/SulP transporter (family) [142-635]
- IPR018045: Sulphate anion transporter, conserved site (conserved_site) [119-140]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:1901682 (sulfur compound transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0042802 (identical protein binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0008514 (organic anion transmembrane transporter activity), GO:0022804 (active transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015116 (sulfate transmembrane transporter activity), GO:0015108 (chloride transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015106 (bicarbonate transmembrane transporter activity), GO:0015291 (secondary active transmembrane transporter activity), GO:0015297 (antiporter activity), GO:0005452 (solute:inorganic anion antiporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051234 (establishment of localization), GO:0048878 (chemical homeostasis), GO:0019725 (cellular homeostasis), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0006885 (regulation of pH), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050801 (monoatomic ion homeostasis), GO:0043207 (response to external biotic stimulus), GO:0035556 (intracellular signal transduction), GO:0006952 (defense response), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0030641 (regulation of cellular pH), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0055082 (intracellular chemical homeostasis), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0006810 (transport), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0034097 (response to cytokine), GO:0071705 (nitrogen compound transport), GO:0070633 (transepithelial transport), GO:0070528 (protein kinase C signaling), GO:0071310 (cellular response to organic substance), GO:0051453 (regulation of intracellular pH), GO:1901699 (cellular response to nitrogen compound), GO:0071702 (organic substance transport), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0006811 (monoatomic ion transport), GO:0015698 (inorganic anion transport), GO:0043434 (response to peptide hormone), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0055080 (monoatomic cation homeostasis), GO:0034341 (response to type II interferon), GO:0072348 (sulfur compound transport), GO:1901701 (cellular response to oxygen-containing compound), GO:0006821 (chloride transport), GO:0015711 (organic anion transport), GO:0071375 (cellular response to peptide hormone stimulus), GO:0019755 (one-carbon compound transport), GO:0008272 (sulfate transport), GO:0071345 (cellular response to cytokine stimulus), GO:0030003 (intracellular monoatomic cation homeostasis), GO:1901653 (cellular response to peptide), GO:1990776 (response to angiotensin), GO:0071346 (cellular response to type II interferon), GO:0015849 (organic acid transport), GO:0006820 (monoatomic anion transport), GO:0046942 (carboxylic acid transport), GO:1904385 (cellular response to angiotensin), GO:0015701 (bicarbonate transport), GO:0006835 (dicarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0045178 (basal part of cell), GO:0045177 (apical part of cell), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0098862 (cluster of actin-based cell projections), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:0120025 (plasma membrane bounded cell projection), GO:0005903 (brush border), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0031526 (brush border membrane), GO:0031253 (cell projection membrane), GO:0016323 (basolateral plasma membrane)