Protein: Lysine-specific demethylase 4C (EC 1.14.11.66) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C) (Q8VCD7)
Organism: Mus musculus (Mouse)
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
Sequence: MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIWKQGKDIYTIDHTKPTPESTPEVKTWLQRKKKLRKPPKSLQGNKPLCKRPKPEEDEEFAEFSGEEGANPAMGPRHLKVTEKPEKALKLGKLEESSAKEALDTRIQVDQSLLNDTKLSGKGCISSSVTAEIPPEDNRASAVISPSQLKEGADCIPLSHGHQAGKESHLLKILKLESPKIPSPLPESNKVLTEGEENDEEGHGSNLEPGEIPEALSEERNGLNIPKIIEGQPKTTKSWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPNFMAEQEYNATVAKMEPNCAICTLLMPYYKPDSSKEENDSRWETAVNEVVQSGRKTKPIIPEMCFIYSEENVDYSPPNAFLEEDGTSLLISCAKCFVRVHASCYGVPSHEVCDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRHRVKKVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHRVNSNAKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQTFYEVMFDDGSFSRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNEYVDDPVYRTFLKSSFQKKCQKRQ
InterPro domains: - IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [709-747]
- IPR003349: JmjN domain (domain) [15-58]
- IPR034732: Extended PHD (ePHD) domain (domain) [750-863]
- IPR002999: Tudor domain (domain) [875-989]
- IPR019787: Zinc finger, PHD-finger (domain) [710-745]
- IPR040477: Lysine-specific demethylase 4-like, Tudor domain (domain) [880-972]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [746-865]
- IPR003347: JmjC domain (domain) [144-310]
- IPR001965: Zinc finger, PHD-type (domain) [687-863]
Interaction partners: - Lysine-specific histone demethylase 1A
- Lysine-specific demethylase 3A demethylase 3A)
- Histone-lysine N-methyltransferase SUV39H1
- Histone H3.2
- Histone H3.1
- Hypoxia-inducible factor 1-alpha
- Lysine-specific demethylase 6B demethylase 6B)
- Lysine-specific demethylase 6A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0032451 (demethylase activity), GO:0016491 (oxidoreductase activity), GO:0140457 (protein demethylase activity), GO:0051213 (dioxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0016706 (2-oxoglutarate-dependent dioxygenase activity), GO:0032452 (histone demethylase activity), GO:0032454 (histone H3K9 demethylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0032501 (multicellular organismal process), GO:0003008 (system process), GO:0006950 (response to stress), GO:0043500 (muscle adaptation), GO:0003012 (muscle system process), GO:0014888 (striated muscle adaptation), GO:0014896 (muscle hypertrophy), GO:0014887 (cardiac muscle adaptation), GO:0014897 (striated muscle hypertrophy), GO:0003300 (cardiac muscle hypertrophy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome)