Protein: DNA (cytosine-5)-methyltransferase 4 (EC 2.1.1.37) (DNA methyltransferase 4) (DNA methyltransferase IIa) (DMT02) (MET02) (O23273)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells (By similarity).
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MEMETKAGKQKKRSVDSDDDVSKERRPKRAAACTNFKEKSLRISDKSETVEAKKEQILAEEIVAIQLTSSLESNDDPRPNRRLTDFVLHDSEGVPQPVEMLELGDIFIEGVVLPLGDEKKEEKGVRFQSFGRVENWNISGYEDGSPVIWISTALADYDCRKPSKKYKKLYDYFFEKACACVEVFKSLSKNPDTSLDELLAAVSRSMSGSKIFSSGGAIQEFVISQGEFIYNQLAGLDETAKNHETCFVENRVLVSLRDHESNKIHKALSNVALRIDESKVVTSDHLVDGAEDEDVKYAKLIQEEEYRKSMERSRNKRSSTTSGGSSRFYIKISEDEIADDYPLPSYYKNTKEETDELVLFEAGYEVDTRDLPCRTLHNWTLYNSDSRMISLEVLPMRPCAEIDVTVFGSGVVAEDDGSGFCLDDSESSTSTQSNDHDGMNIFLSQIKEWMIEFGAEMIFVTLRTDMAWYRLGKPSKQYAPWFGTVMKTVRVGISIFNMLMRESRVAKLSYANVIKRLCGLEENDKAYISSKLLDVERYVVVHGQIILQLFEEYPDKDIKRCPFVTSLASKMQDIHHTKWIIKKKKKILQKGKNLNPRAGIAPVVSRMKAMQATTTRLVNRIWGEFYSIYSPEVPSEAINAENVEEEELEEVEEEDENEEDDPEENELEAVEIQNSPTPKKIKGISEDMEIKWDGEILGKTSAGEPLYGRAFVGGDVVVVGSAVILEVDDQDDTQLICFVEFMFESSNHSKMLHGKLLQRGSETVLGMAANERELFLTNECLTVQLKDIKGTVSLEIRSRLWGHQYRKENIDVDKLDRARAEERKTNGLPTDYYCKSLYSPERGGFFSLPRNDMGLGSGFCSSCKIRENEEERSKTKLNDSKTGFLSNGIEYHNGDFVYVLPNYITKDGLKKGSRRTTLKCGRNVGLKAFVVCQLLDVIVLEESRKASKASFQVKLTRFYRPEDISEEKAYASDIQELYYSQDTYILPPEAIQGKCEVRKKSDMPLCREYPILDHIFFCEVFYDSSTGYLKQFPANMKLKFSTIKDETLLREKKGKGVETGTSSGMLMKPDEVPKEKPLATLDIFAGCGGLSHGLENAGVSTTKWAIEYEEPAGHAFKQNHPEATVFVDNCNVILRAIMEKCGDVDDCVSTVEAAELAAKLDENQKSTLPLPGQVDFINGGPPCQGFSGMNRFSHGSWSKVQCEMILAFLSFADYFRPKYFLLENVKKFVTYNKGRTFQLTMASLLEMGYQVRFGILEAGTYGVSQPRKRVIIWAASPEEVLPEWPEPMHVFDNPGSKISLPRGLRYDAGCNTKFGAPFRSITVRDTIGDLPPVENGESKINKEYGTTPASWFQKKIRGNMSVLTDHICKGLNELNLIRCKKIPKRPGADWRDLPDENVTLSNGLVEKLRPLALSKTAKNHNEWKGLYGRLDWQGNLPISITDPQPMGKVGMCFHPEQDRIITVRECARSQGFPDSYEFSGTTKHKHRQIGNAVPPPLAFALGRKLKEALYLKSSLQHQS
InterPro domains: - IPR001025: Bromo adjacent homology (BAH) domain (domain) [715-1033]
- IPR017198: DNA (cytosine-5)-methyltransferase 1-like (family) [1-1519]
- IPR043151: Bromo adjacent homology (BAH) domain superfamily (homologous_superfamily) [687-1038]
- IPR018117: DNA methylase, C-5 cytosine-specific, active site (active_site) [1175-1187]
- IPR050390: DNA Cytosine-5 Methyltransferase (family) [425-1514]
- IPR022702: DNA (cytosine-5)-methyltransferase 1, replication foci domain (domain) [76-519]
- IPR029063: S-adenosyl-L-methionine-dependent methyltransferase superfamily (homologous_superfamily) [1062-1509]
- IPR001525: C-5 cytosine methyltransferase (family) [1078-1512]
- IPR031303: DNA methylase, C-5 cytosine-specific, conserved site (conserved_site) [1487-1505]
Interaction partners: - Adenosylhomocysteinase 1
- Adenosylhomocysteinase 2
- Transcription factor GTE2
- Galactokinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0005515 (protein binding), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008168 (methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:2000241 (regulation of reproductive process), GO:0032259 (methylation), GO:0019222 (regulation of metabolic process), GO:0022402 (cell cycle process), GO:0006807 (nitrogen compound metabolic process), GO:0007049 (cell cycle), GO:0051301 (cell division), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0009892 (negative regulation of metabolic process), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0009292 (horizontal gene transfer), GO:0044237 (cellular metabolic process), GO:2000242 (negative regulation of reproductive process), GO:0051093 (negative regulation of developmental process), GO:0044238 (primary metabolic process), GO:0009294 (DNA-mediated transformation), GO:0048316 (seed development), GO:0000910 (cytokinesis), GO:1903047 (mitotic cell cycle process), GO:0046483 (heterocycle metabolic process), GO:0048731 (system development), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0043414 (macromolecule methylation), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0009793 (embryo development ending in seed dormancy), GO:0009910 (negative regulation of flower development), GO:0043170 (macromolecule metabolic process), GO:0009909 (regulation of flower development), GO:0008356 (asymmetric cell division), GO:0048831 (regulation of shoot system development), GO:0048580 (regulation of post-embryonic development), GO:1901360 (organic cyclic compound metabolic process), GO:2000026 (regulation of multicellular organismal development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0044260 (cellular macromolecule metabolic process), GO:0000278 (mitotic cell cycle), GO:0048581 (negative regulation of post-embryonic development), GO:0061458 (reproductive system development), GO:0006325 (chromatin organization), GO:0010468 (regulation of gene expression), GO:0006306 (DNA methylation), GO:0043412 (macromolecule modification), GO:0061640 (cytoskeleton-dependent cytokinesis), GO:0090304 (nucleic acid metabolic process), GO:0006259 (DNA metabolic process), GO:0000281 (mitotic cytokinesis), GO:0010629 (negative regulation of gene expression), GO:0010154 (fruit development), GO:0006304 (DNA modification), GO:0010216 (negative regulation of gene expression via chromosomal DNA cytosine methylation), GO:0040029 (epigenetic regulation of gene expression), GO:0045814 (negative regulation of gene expression, epigenetic), GO:0032776 (DNA methylation on cytosine), GO:0006305 (DNA alkylation), GO:0006349 (regulation of gene expression by genomic imprinting)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)