wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Late embryogenesis abundant protein At3g53040 (LEA domain-containing protein At3g53040) (Q9LF88)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: May function in the proximal abscission zone cells to prevent water loss after floral organ shedding (Probable). May be involved in the reestablishment of desiccation tolerance in germinated seeds (Probable).
Sequence: MASGQREAERSAKAERAEAAASLAAEDLKDINKGDVTYKLTERTTTTEPERPGLIGSVMKAVQGTKDAVIGKSHDTAESTREGADIASEKAAGMRDTTGEVRDSTAQKTKETADYTADKAREAKDKTADKTKETADYAAEKAREAKDRTADKTKETAEYTAEKAREAKDKTADKLGEYKDYTAEKAKEAKDTTAEKLGEYKDYTVDKAKEAKDKTAEKAKETAEYTSDKARETKDKTAEKVGEYKDYTAEKAKETADKAREAKDKTAEKVGEYRDYTAEKATETKDAGVSKIGELKDSAVDTAKRAMGFLSGKTEETKQKAVETKDTAKEKMDEAGEEARRKMEEMRLEGKKLDEDASRKTQQSTESAADKAHETKDSVAQRGEEGKGSIMGALGNMTGAIKSKLTGATTPSDEETRASAHGDESTGKTVVAVDVKDTRPGYVATVLKEADQMTGQTFNDVGEIDDEEKVRIVVGEKKL
InterPro domains: - IPR004238: Late embryogenesis abundant protein ECP63-like domain (domain) [135-295]
Interaction partners: - Late embryogenesis abundant protein
- Late embryogenesis abundant protein
- AT1G27990 protein
- At2g23110
- Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 8
- Reticulon-like protein B13
- SNF1-related protein kinase regulatory subunit gamma-like PV42b
- Oleosin
- Late embryogenesis abundant protein 18
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0001101 (response to acid chemical), GO:0009266 (response to temperature stimulus), GO:1901700 (response to oxygen-containing compound), GO:0009414 (response to water deprivation), GO:0010035 (response to inorganic substance), GO:0009415 (response to water), GO:0009409 (response to cold), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0050826 (response to freezing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Exocrine gland-secreting peptide 15 (A8R0U7)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MASFPLMYFLIILVFPTILPEGMALKRTEKEPNISADLNDDFEISFIQTIRDRLDLMRMLSGSVIGKIYLNYDVVMYCRECSLTM
InterPro domains: - IPR032253: Exocrine gland-secreted peptide Esp1/Esp22 (family) [5-71]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005186 (pheromone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0022008 (neurogenesis), GO:0030030 (cell projection organization), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0007399 (nervous system development), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0031175 (neuron projection development), GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Phosphatidylglycerol/phosphatidylinositol transfer protein (PG/PI-TP) (Q9C0X9)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Sequence: MRLTTFIYAITCLPIFISASSWFSSFSFGESKSTDLVSSTSEKIPGANPASYCADWDRGDDHVVVDYINLIPNPPAAGKNLTIETEINVGTTVLNGSYVDIQVKYGFVRIVNERLDICDKAYELAAVECPVEPGIITKQATISLPWAIPPGRYHVLATAYNADGEQLTCVSASVSFSHFGFQLINQDH
InterPro domains: - IPR014756: Immunoglobulin E-set (homologous_superfamily) [49-175]
- IPR033917: ML domain, phosphatidylinositol/phosphatidylglycerol transfer protein (domain) [51-174]
- IPR039670: Sterol transport protein NPC2-like (family) [26-176]
- IPR003172: MD-2-related lipid-recognition domain (domain) [48-176]
Interaction partners: - 2-hydroxyacyl-CoA lyase
- Probable sterol O-acyltransferase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0033036 (macromolecule localization), GO:0010876 (lipid localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006869 (lipid transport), GO:0071702 (organic substance transport), GO:0032365 (intracellular lipid transport), GO:0032366 (intracellular sterol transport), GO:0015850 (organic hydroxy compound transport), GO:0015918 (sterol transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005773 (vacuole), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000323 (lytic vacuole), GO:0043231 (intracellular membrane-bounded organelle), GO:0005775 (vacuolar lumen), GO:0070013 (intracellular organelle lumen), GO:0000322 (storage vacuole), GO:0000328 (fungal-type vacuole lumen), GO:0000324 (fungal-type vacuole)
Protein: Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) (P30968)
Organism: Homo sapiens (Human)
Function: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
InterPro domains: - IPR001658: Gonadotrophin-releasing hormone receptor family (family) [13-309]
- IPR017452: GPCR, rhodopsin-like, 7TM (domain) [52-323]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [73-328]
Interaction partners: - Progonadoliberin-1
- Progonadoliberin-2
- Guanine nucleotide-binding protein G
- KiSS-1 receptor
- Metastasis-suppressor KiSS-1
- Guanine nucleotide-binding protein G
- Follitropin subunit beta
- Guanine nucleotide-binding protein subunit alpha-11
- Tachykinin-3
- Anosmin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0048511 (rhythmic process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051716 (cellular response to stimulus), GO:0007623 (circadian rhythm), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0050794 (regulation of cellular process), GO:0048512 (circadian behavior), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0007622 (rhythmic behavior)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Multidrug efflux pump accessory protein AcrZ (AcrAB-TolC multidrug efflux pump accessory protein AcrZ) (Acridine resistance protein Z) (P0AAW9)
Organism: Escherichia coli (strain K12)
Function: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
Subcellular location: Cell inner membrane {ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005, ECO:0000269|PubMed:21778229}. Note=In sucrose cushions fractionates with both the inner and outer membranes.
Sequence: MLELLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGVGKKDQPGQNH
InterPro domains: - IPR019702: Multidrug efflux pump accessory protein AcrZ (family) [1-47]
- IPR053730: Multidrug Efflux Pump Accessory AcrZ (homologous_superfamily) [1-49]
Interaction partners: - Multidrug efflux pump subunit AcrB
- Multidrug efflux pump subunit AcrA
- Outer membrane protein TolC
- Cytochrome bd-I ubiquinol oxidase subunit X
- Putative inhibitor of glucose uptake transporter SgrT
- Small protein MgtS
- Small protein MntS
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0009991 (response to extracellular stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0042594 (response to starvation), GO:0071496 (cellular response to external stimulus), GO:0033554 (cellular response to stress), GO:0031669 (cellular response to nutrient levels), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Universal stress protein Rv3134c (USP Rv3134c) (P9WFD3)
Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Function: Not known
Sequence: MSDPRPARAVVVGIDGSRAATHAALWAVDEAVNRDIPLRLVYVIDPSQLSAAGEGGGQSAARAALHDASRKVEATGQPVKIETEVLCGRPLTKLMQESRSAAMLCVGSVGLDHVRGRRGSVAATLAGSALCPVAVIHPSPAEPATTSQVSAVVAEVDNGVVLRHAFEEARLRGVPLRAVAVHAAETPDDVEQGSRLAHVHLSRRLAHWTRLYPEVRVDRAIAGGSACRHLAANAKPGQLFVADSHSAHELCGAYQPGCAVLTVRSANL
InterPro domains: - IPR014729: Rossmann-like alpha/beta/alpha sandwich fold (homologous_superfamily) [1-254]
- IPR006015: Universal stress protein A family (family) [7-137]
- IPR006016: UspA (domain) [8-137]
Interaction partners: - DNA-binding transcriptional activator DevR/DosR
- Oxygen sensor histidine kinase response regulator DevS/DosS
- Probable membrane protein Rv1733c
- Uncharacterized protein Rv1738
- Dormancy associated translation inhibitor
- Putative NAD
- Alpha-crystallin
- Putative NAD
- Uncharacterized protein Rv3127
- Uncharacterized protein Rv0080
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0097367 (carbohydrate derivative binding), GO:1901265 (nucleoside phosphate binding), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0032555 (purine ribonucleotide binding), GO:0017076 (purine nucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0046677 (response to antibiotic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0005886 (plasma membrane), GO:0009274 (peptidoglycan-based cell wall)
Protein: Potassium uptake protein TrkA, putative (Q72F06)
Organism: Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough) (Desulfovibrio vulgaris)
Function: Not known
Sequence: MATPKLEIGVIGLGKFGLQVSRTLVELGHSVVGIDSTEGRIRQAQDILSQVYQGNAADPAVLQQLRFQDLDCVIVSVGNSMETSLLVTLNLQEIGVRKIWVKAVSTEHKKVLTRLGVDHVILPEHDVATHLAHRLVNPGMLDLLPLGGGGQILLQELTVDKWAGRTLLDLRLANEHGVMVVAVKPAAFREYRFVPAAHEVLQQGDKLVVIGRHEDVLRLEP
InterPro domains: - IPR003148: Regulator of K+ conductance, N-terminal lobe (domain) [5-123]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [8-138]
- IPR050721: Trk/Ktr/HKT Potassium Transport (family) [8-217]
- IPR006037: Regulator of K+ conductance, C-terminal (domain) [138-221]
- IPR036721: Regulator of K+ conductance, C-terminal domain superfamily (homologous_superfamily) [134-221]
Interaction partners: - Potassium uptake protein, TrkH family
- Heptosyltransferase family protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0051259 (protein complex oligomerization), GO:0051262 (protein tetramerization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (RING finger protein 14) (F1RB95)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q9UBS8}. Nucleus {ECO:0000250|UniProtKB:Q9UBS8}.
Sequence: MSADQEAKEDELLALASIYDEEEFHRAESGKEGEIHLCLELPPNFKLLVKGQKSAEHNISFLPPLVLSFDLPDDYPSTSAPIFTISSKWLTRVQITALCRKLDELWEENQGNVVLFTWIQFLKEETLDFLGIQSPLEIQRSGSQPQCEPAQKHAADASGEKSKVQDLDPRAVQEVDAQTDILTQLLDFDEAQKQRVFDGKAFCCGICYSEKLGCDCLLFKECEHVYCKACIKEYFQIQIKDGKVQCLNCPEPKCASTATPTQVKLLVGEDEFARYDRLLLQSSLDLMADVVYCPRMSCCMAVMVEPDSTMGICPSCRYAFCTLCRRSYHGLSHCIATADELRSLRDEYLSSSEEGKKFLEKRFGKRVIQRAVEESFSTDWLKTNCKQCPCCGTNIQKAHGCNKMTCSSCQKYFCWICLGALSRVNPYSHFNNPDSPCYNQLFHGMEMEEDEAFGSDEDD
InterPro domains: - IPR031127: E3 ubiquitin ligase RBR family (family) [109-440]
- IPR044066: TRIAD supradomain (domain) [200-441]
- IPR006575: RWD domain (domain) [6-129]
- IPR047548: E3 ubiquitin-protein ligase RNF14, Rcat domain (domain) [373-440]
- IPR017907: Zinc finger, RING-type, conserved site (conserved_site) [222-231]
- IPR002867: IBR domain (domain) [273-437]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [198-285]
- IPR016135: Ubiquitin-conjugating enzyme/RWD-like (homologous_superfamily) [1-131]
- IPR031128: E3 ubiquitin-protein ligase RNF14, RING finger, HC subclass (domain) [197-255]
- IPR001841: Zinc finger, RING-type (domain) [204-249]
Interaction partners: - Family with sequence similarity 177 member A1.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:0030111 (regulation of Wnt signaling pathway), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0060828 (regulation of canonical Wnt signaling pathway), GO:0090263 (positive regulation of canonical Wnt signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Cathepsin L-like proteinase (EC 3.4.22.-) (Q24940)
Organism: Fasciola hepatica (Liver fluke)
Function: Thiol protease. Probably involved in interaction with host tissues. Displays a similar activity to that of papain. Has high activity on Z-Phe-Arg-NHMec, but no activity on Z-Arg-NHMec.
Subcellular location: Secreted {ECO:0000269|PubMed:8192668}.
Sequence: MRLFILAVLTVGVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVESDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWGERGYIRMARNRGNMCGIASLASLPMVARFP
InterPro domains: - IPR013128: Peptidase C1A (family) [20-314]
- IPR025661: Cysteine peptidase, asparagine active site (active_site) [284-303]
- IPR000169: Cysteine peptidase, cysteine active site (active_site) [126-137]
- IPR039417: Papain-like cysteine endopeptidase (domain) [109-320]
- IPR000668: Peptidase C1A, papain C-terminal (domain) [108-321]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [19-321]
- IPR025660: Cysteine peptidase, histidine active site (active_site) [267-277]
- IPR013201: Cathepsin propeptide inhibitor domain (I29) (domain) [21-80]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008234 (cysteine-type peptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032963 (collagen metabolic process), GO:0009056 (catabolic process), GO:0030574 (collagen catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (Q8I5H7)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MYKYTSINKSDKIYETHNMEEKKKKGNNNNFSGLLNNEIDDNNKKEKLKNSISKMYSNHKNRENFNECEKEDLVVIDEKDNNKKKKKNMTNTFEQDNNYNMNDNKRLGSFFKINDKCESINENVNNINKQSLKDSILFDNINEKEYFNETKEENKEGNKSNDIEKINCMKVKKKTVKKNKKKINKIINNKNKISKSNDIEEQIINISKHIYKILNISKLPKCDILKRTNRRYAETFLYLTNGYNLDIEQIIKRSLYKRMYKNNSIIKVTGIHIYSLCKHHLLPFEGTCDIEYIPNKYIIGLSKFSRIVDVFSRRLQLQEDLTNDICNALKKYLKPLYIKVSIVAKHLCINMRGVKEHDAKTITYASYKAEKENPTVHSLNIDSSVENLN
InterPro domains: - IPR001474: GTP cyclohydrolase I (family) [85-383]
- IPR043133: GTP cyclohydrolase I, C-terminal/NADPH-dependent 7-cyano-7-deazaguanine reductase (homologous_superfamily) [254-381]
- IPR020602: GTP cyclohydrolase I domain (domain) [207-378]
Interaction partners: - Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
- Vacuolar protein sorting-associated protein VTA1, putative
- Inosine triphosphate pyrophosphatase
- Bis
- Alkaline phosphatase, putative
- 6-pyruvoyltetrahydropterin synthase
- Nucleoside diphosphate kinase
- nucleoside-diphosphate kinase
- Coronin
- Guanylate cyclase beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds), GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines), GO:0019238 (cyclohydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006575 (cellular modified amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0042398 (cellular modified amino acid biosynthetic process), GO:0006760 (folic acid-containing compound metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0042558 (pteridine-containing compound metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0042559 (pteridine-containing compound biosynthetic process), GO:0009396 (folic acid-containing compound biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)