Protein: 1,3-beta-glucan synthase component bgs3 (EC 2.4.1.34) (1,3-beta-D-glucan-UDP glucosyltransferase) (Q9P377)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Alternate catalytic subunit of the 1,3-beta-glucan synthase (GS) complex (By similarity). Synthesizes 1,3-beta-glucan, a major structural component of the yeast cell wall (By similarity). Required for cell wall biosynthesis and cell elongation.
Subcellular location: Membrane {ECO:0000269|PubMed:12582133}; Multi-pass membrane protein {ECO:0000269|PubMed:12582133}. Note=Found at the growing tips during interphase and at the septum prior to cytokinesis.
Sequence: MDYKKGEHSPSSSIQILSDDATINSNYAYGEQLQSNDQYNNIQHPAPSFANPFIHEQDDSYSDILEEEPDEDAYDSPERPSSTEEFISQDESNISAGSSFMFPYNRGHPLSKRHDSIMVDEFGHEYIVEGDSIASADEAIDYDALYASWTAETKAPILAIDIENIYIELAMKFGFQWDNMRNMFDYLMVMLDSRASRMTPQEALLTLHADYIGGPQSNFKKWYFACKMDQFDLKSGVLSFISRDPSTQVPYKDMSSCEALWISRMDELSNYERIEQLALYLLCWGEANNVRFMPECLCFIYKVAYDYLISPSFKEQKNPAPKDYFLDNCITPLYNLMHDQQYEIRDQKYVRKEKDHASIIGYDDINQMFWYSKGLKALLLSDGSRIMDADVASRYFLLADIQWQRVCYKSFRESRTWLHFLHNFSRIWILHISVFWYFTVYNSPTIYTPNFHYLEGTQPARAAKWCAPALAGAVASFISFLALILEAYFVPRNNPGAQPVIPRLIFVSILIALNIVPAAFIFGFSNATQQHYRSREIVGYVHFFFSIGCVAYQSFIPLPFLLGPRFKFRSSSRKYLANSYFTNDIASLPWGRTLLSAALWITVFIAKFVESYYFLTLSVRDPIRFLQRMKPYDCYDFMIGASLCSHQPKFLLSLVYLTDLVLFFLDTYLWYMLISTMFSIAYSFYMGSAIWTPWRVIFSNLPRRIYFTLLAYKDLSTEFKPKIYVGQIWNSIMISMYREHLLSLEHLKGLLYQQVGSEYFGKQTFQSPKFFMEAAKGLNKWDAFFRRNSEAERRISFFAQSLGGKIPDAVPVPKMPSFTVLIPHYGEKILLSLREIIREQDPMSRITLLEYLKQLYPNDWDNFVQDTKLMAGDVGVEETKSDVKSEKGKKQGTVKEDLPFYCIGFKSTAPEYTLRTRIWASLRSQTLYRTASGMMNYSRALKLLYRVEQPNLLDDCDGNFERLEHQLEQMAYRKFRLCISMQRYAKFNRDEYENAEFLLRAHPELQIAYLDQDPSEDGEEPKVYATLINGFCPFENGRRLPKYRIRLSGNPILGDGKADNQNMALPFVRGEYLQLIDANQDNYIEECMKIRNVLSEFEEMDCATLTPYTKKGNARHPVAMLGAREYVFSENSGILGDVAAGKEQTFGTLFSRSLALIGGKLHYGHPDFLNTIFMTTRGGVSKAQKGLHVNEDIYAGMTALQRGGRIKHCDYFQCGKGRDLGFGTIINFTTKIGTGMGEQSLSREYFYLGTQLPFFRMLSFYYAHAGFHLNNVFIMISMQLLMLVFVNLGAMYHTVEICDYQAGAAINASLYPPGCYMLKPVLDWIRRCIISIFIVFFISFLPLVVHDLLEKGVIRAVARLCKQIFSLSPMFEVFVTQNYANSIFTNLTYGGARYIATGRGLATTRVPFSVLYSLYTGSSIYLGSRLIMMLLFGTMTVWTTHYVYFWVTMFALVICPFIYNPHQFSFVDFFVDYREFLRWLSRGNTKGHAHSWIGFCRLARTRITGVNRKVKGSPSNKLTMDMPRAGLRNVIFTEVFLPACFAFFTICAYTFMNSQPGLEDKSRAVNGFIRIWIMAALPIAISTAALLILLMFSCMLGPLLRKCSKRYGAVLAALAHAVSVFGLVFTFEALWFLEAWSFSKTVLGCIVIFAIHRLVFKLVVVFLLPREVASGENNYSWWDGHWFGRKGIPYMPIQFIREFMCKVVEMNLFAMDFILSHCILFSLTPILCIPFIDIPHSVLLFWLHPSRQIRPPIYTRKQNQLRRRTFYRYSLLFFALLCTFVAMIVVPLVLDQKLSYQFKFENSVKFFRLMQPSLGVLPNTNKNTSE
InterPro domains: - IPR056261: 1,3-beta-glucan synthase component FKS1-like, domain-2 (domain) [411-584]
- IPR026899: 1,3-beta-glucan synthase component FKS1-like, domain-1 (domain) [271-383]
- IPR003440: Glycosyl transferase 48 domain (domain) [784-1599]
Interaction partners: - Probable UTP--glucose-1-phosphate uridylyltransferase
- Probable UTP--glucose-1-phosphate uridylyltransferase
- Glucan 1,3-beta-glucosidase 1
- Glucan 1,3-beta-glucosidase 2
- Glucan 1,3-beta-glucosidase
- Cell wall alpha-1,3-glucan synthase ags1
- Uncharacterized oxidoreductase pbr1
- 1,3-beta-glucan synthase component bgs4
- 1,3-beta-glucan synthase component bgs1
- 1,3-beta-glucan synthase component bgs2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0008194 (UDP-glycosyltransferase activity), GO:0046527 (glucosyltransferase activity), GO:0035251 (UDP-glucosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0071840 (cellular component organization or biogenesis), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0044249 (cellular biosynthetic process), GO:0016043 (cellular component organization), GO:0005975 (carbohydrate metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0044262 (cellular carbohydrate metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0044264 (cellular polysaccharide metabolic process), GO:0016051 (carbohydrate biosynthetic process), GO:0005976 (polysaccharide metabolic process), GO:0034637 (cellular carbohydrate biosynthetic process), GO:0000271 (polysaccharide biosynthetic process), GO:0033692 (cellular polysaccharide biosynthetic process), GO:0044042 (glucan metabolic process), GO:0006073 (cellular glucan metabolic process), GO:0009250 (glucan biosynthetic process), GO:0051273 (beta-glucan metabolic process), GO:0051274 (beta-glucan biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0042763 (intracellular immature spore), GO:0071944 (cell periphery), GO:0060187 (cell pole), GO:0070938 (contractile ring), GO:0032153 (cell division site), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0051286 (cell tip), GO:0043229 (intracellular organelle), GO:0032154 (cleavage furrow), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0043228 (non-membrane-bounded organelle), GO:0005794 (Golgi apparatus), GO:0098590 (plasma membrane region), GO:0005826 (actomyosin contractile ring), GO:0000935 (division septum), GO:0035838 (growing cell tip), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0110085 (mitotic actomyosin contractile ring), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0099738 (cell cortex region), GO:0051285 (cell cortex of cell tip), GO:0030864 (cortical actin cytoskeleton), GO:0005856 (cytoskeleton), GO:0015629 (actin cytoskeleton)