Protein: PHD finger protein rhinoceros (D7EJ84)
Organism: Tribolium castaneum (Red flour beetle)
Function: May function as a negative regulator of the EGFR/Ras/MAPK signaling pathway during eye development
Sequence: MSQRAKRPNRSDDGSVPVKRRKRTAAEEEEAASLAVWQPRSNDLKSIYNRTTTEAPAELFRKDLISAMKLPDSEPLASNEYWVIVDQWKQEWERGVQVPVNPDSLPEPSVTVTQNTPLKLQHEFKLPKNKYIRITKDENFKIEEHALSNAPAQSEAACSYDLDECDVSWLRILNSERSQCGQSPINSEQLERVIEQFELCCWDKIQSILRNEEGLGIEYDENVICDVCRSPDSEEGNEMVFCDSCNICVHQACYGITRIPEGQWLCCTCHLSKRPKCVLCPNKGGAMKCTRSGQKWAHVSCALWIPEVSIGCVEKMEPITKISSIPQSRWALICVLCRERVGACIQCSVKTCKTAYHVTCAFKHGLEMRAIIEDENADDGVKLRSYCEKHSKSSKNKEKSVCSGSEDDDSRRKKRKDMTSEEKNQARAARLQEIESEFFKHVSIKDVSIHLDVDNDALHHIYNYWKLKRKAGNNKPLLPPKSEDVDMLSHKREQADMEKMKMFVQLRQDLERVRNLCYMVSRREKLSRSFFRLREQTFYKQTAVLEAANNLPNVVVQAVIEANHGPSIYDRLYSHEDAEDHTSDFERILTRIAGVKSPTDSGDEKRTELNGLFKDKNPYKKIYFNGSSNRRSGSLYGSSSSSDEKDRLNAATTSEDEDKSKKKSSSSVRKPNNNNNKASDRRRKRHSASSKIESSSEEDSKQKTKKTWGQFSRLKQVERELGYSGSDSDELMPIRASQKSDTKQMSSIYSDSDSSDVSMTKASDSQQNKLRTKAAVKEFSHKPSTSNKTSPENKKNKKKESPTKKKDYDPSDLIVPQRQAAKKATENLKSTTTRVVKEQMDEPSVKVEEKPAKLPKPKAKTKETVKEVKEVKKESAVKTSDVFDLDKETDNAEILAYVPQRQAAKKAAEHIKSGLGKPVAPSSVDELEKNKLESTVVKKKEAEKQQPAKVPESKRKSSSNSSSSSSSSSSTSSSTSSSSDSDDEVPPSQQQAQQPRSESLFSNYSSKECRETAKRTNASKDWPFLDKGAKSAAAAASSSSTDSSDSSRPTSPIITTTTTTKTTSPDKKSTTTQREEQTRMRGKGRPATTAARGRPRQSSKSGDRVGDANVRLRNLSDSQRGDAKCRKGKQDEVAEKETKSVNKLQSPVRKTDKKLTESKESSEVSNLEKEILERKAGKQGSSKTKSTLDRLFGSPPDKKDEKKPLNKTTKPTKPERVKSTVKENKEPEKIASPVKKSPVKSKNIDEIFTQKTVLNENKIEVKEKEKHPTPKREEIEPAPKIEDFKQNNEKLTEPEKKLPHSRSIFSPPHLKDNLLDFDNLDDGFGISKDEEIMKGPLTFNFGNTSLFKEDSKEDSARETLNLVEKLRMEMSKKSTSCDVDDGASVSSSTKNECDRTEFAEQVVPNCVAEKNDAKVDDVPPPTVNLEMRVEVTEAKGFADRGQDYRFMSCEADVPLEQNKNIPIQQHHGLSDHGISGQGDERWVPPSEAYTAAPPIDPSNYGSESQQPLQTPQHFMQQYSLNKTQPLLNAIPPQIEMRLHDDTLKNPSPTLHDRRISQTPLNEDCMPSPSPYADIHPQAKWADSEIMPNRRSSSSSAASTSSSCSRRNDDDDLKLRPDVMMVNHQALEIGYLHPFPPELFPTLSDSSQFVSPVSLLHPPPLNPSLAFPSTAPAMLPPAFAPFPPAQVMAPTLSKPLEDVPHCTAAFTSSQHNMALTAAIANLPPSLPKEVEALPEDEVVPTTQSNVLSSPSPSIKSNSSGKKSPSKPTRTSARVTSQGKSPKQDVVKPSGRGRGEAKRNSVKSNAARGRGRARGRGRAHSHNDHEFISNTIHNKLVGTVYDLDFDDDISSENVDLKSMRERRKSVDVQKTELKESSDSPSQKKYNDLRELRPPSPVKDTTPKPAEVEPIFPDIVQPVLPGPVDMRTYNTNFDQSYNEANLLRAFDSGTTEPPVNEEIDEEFEKELQTALTTPSKKPDEPPANIKVSLSDSRNQLKVKIKGPIANYSSTIPPLPPPVTVSSISNNVISNNSIGVSSGTSNLRRMRKKELLRQYWTQDMNMDDSSCAPGFNATPTVPPVNRTIITIPKAVASMTSIPTKDDYRDYRTDDVIETKQHRKEAKSRPGALSRELRQLDLSLDEDALHERRRSIGSNNSTNYDSGTNKRRGRPPRPSQQTTGTPKIKIKIGNSIVGKIDDKRDRIRPPKKRLANINMPSVEDLKRESMKFRKLVMADFDEGKEKRKKKDKSEKRKRKKAKPEVRIISNESQNKLIIRIGKKGERTSGGEEGGAPIKLKLARCQEGSGYVMKSEEAAQSPPPPPPPPPPTLGPPPLPLNKDCEVR
InterPro domains: - IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [213-285]
- IPR019542: Enhancer of polycomb-like, N-terminal (domain) [65-198]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [225-269]
- IPR050701: Histone Modification Regulator (family) [35-702]
- IPR001965: Zinc finger, PHD-type (domain) [224-391]
- IPR034732: Extended PHD (ePHD) domain (domain) [274-391]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [212-393]
- IPR019787: Zinc finger, PHD-finger (domain) [222-272]
Interaction partners: - Chromatin modification-related protein MEAF6
- Inhibitor of growth protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044238 (primary metabolic process), GO:0000902 (cell morphogenesis), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0036211 (protein modification process), GO:0022008 (neurogenesis), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)