Protein: Retinaldehyde-binding protein 1 (Cellular retinaldehyde-binding protein) (Q9Z275)
Organism: Mus musculus (Mouse)
Function: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Subcellular location: Cytoplasm.
Sequence: MSDGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEKEETREEAVRELQELVQAQAASGEELALAVAERVQARDSAFLLRFIRARKFDVGRAYELLKGYVNFRLQYPELFDSLSMEALRCTIEAGYPGVLSSRDKYGRVVMLFNIENWHCEEVTFDEILQAYCFILEKLLENEETQINGFCIVENFKGFTMQQAAGLRPSDLKKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKNKLLQRVFVHGDDLDGFFQEIDENILPADFGGTLPKYDGKVVAEQLFGPRAEVENTAL
InterPro domains: - IPR011074: CRAL/TRIO, N-terminal domain (domain) [64-117]
- IPR036865: CRAL-TRIO lipid binding domain superfamily (homologous_superfamily) [124-305]
- IPR036273: CRAL/TRIO, N-terminal domain superfamily (homologous_superfamily) [45-129]
- IPR001251: CRAL-TRIO lipid binding domain (domain) [136-297]
Interaction partners: - Retinoid isomerohydrolase
- Retinol dehydrogenase 11
- Retinol dehydrogenase 5
- Retinol dehydrogenase 10
- Rhodopsin
- Acyl-CoA wax alcohol acyltransferase 2
- Bestrophin-1
- Short-chain dehydrogenase/reductase family 9C member 7
- Lecithin retinol acyltransferase
- Recoverin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0003008 (system process), GO:0044238 (primary metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0050877 (nervous system process), GO:0006766 (vitamin metabolic process), GO:0006629 (lipid metabolic process), GO:0006720 (isoprenoid metabolic process), GO:0007600 (sensory perception), GO:0006775 (fat-soluble vitamin metabolic process), GO:0050953 (sensory perception of light stimulus), GO:0006721 (terpenoid metabolic process), GO:0016101 (diterpenoid metabolic process), GO:0007601 (visual perception), GO:0001523 (retinoid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0005813 (centrosome), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005634 (nucleus), GO:0015630 (microtubule cytoskeleton)