Protein: V-type proton ATPase subunit a (Q9XZ10)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
Sequence: MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKLRYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTELKHILRKTQVFFDESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLKLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKSTVMENKFLQLSPKGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTYFRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLFNTPKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQPIAGATSDAEAGGVSNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIENGAAAAEE
InterPro domains: - IPR026028: ATPase, V0 complex, subunit 116kDa, eukaryotic (family) [1-853]
- IPR002490: V-type ATPase, V0 complex, 116kDa subunit family (family) [3-848]
Interaction partners: - V-type proton ATPase subunit d 1
- V-type proton ATPase 16 kDa proteolipid subunit c
- ATPase H
- V-type proton ATPase subunit B
- V-type proton ATPase subunit E
- V-type proton ATPase 16 kDa proteolipid subunit c
- V-type proton ATPase subunit H
- Probable V-type proton ATPase subunit d 2
- V-type proton ATPase catalytic subunit A isoform 1
- V-type proton ATPase subunit G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0005516 (calmodulin binding), GO:0009881 (photoreceptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0019725 (cellular homeostasis), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0006885 (regulation of pH), GO:0071840 (cellular component organization or biogenesis), GO:0001763 (morphogenesis of a branching structure), GO:0061919 (process utilizing autophagic mechanism), GO:0009056 (catabolic process), GO:0035295 (tube development), GO:0050801 (monoatomic ion homeostasis), GO:0055082 (intracellular chemical homeostasis), GO:0048729 (tissue morphogenesis), GO:0009888 (tissue development), GO:0009314 (response to radiation), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0061138 (morphogenesis of a branching epithelium), GO:0016043 (cellular component organization), GO:0030641 (regulation of cellular pH), GO:0006914 (autophagy), GO:0035239 (tube morphogenesis), GO:0016236 (macroautophagy), GO:0009416 (response to light stimulus), GO:0060562 (epithelial tube morphogenesis), GO:0055080 (monoatomic cation homeostasis), GO:0048880 (sensory system development), GO:0051453 (regulation of intracellular pH), GO:0007423 (sensory organ development), GO:0002009 (morphogenesis of an epithelium), GO:0043933 (protein-containing complex organization), GO:0006873 (intracellular monoatomic ion homeostasis), GO:0060429 (epithelium development), GO:0022411 (cellular component disassembly), GO:0048754 (branching morphogenesis of an epithelial tube), GO:0060541 (respiratory system development), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0097352 (autophagosome maturation), GO:0001654 (eye development), GO:0032984 (protein-containing complex disassembly), GO:0150063 (visual system development), GO:0051452 (intracellular pH reduction), GO:0060446 (branching involved in open tracheal system development), GO:0007424 (open tracheal system development), GO:0048749 (compound eye development), GO:0007430 (terminal branching, open tracheal system)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0008021 (synaptic vesicle), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070382 (exocytic vesicle), GO:0005769 (early endosome), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)