Protein: Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9) (Q8BFU1)
Organism: Mus musculus (Mouse)
Function: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity). Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (By similarity). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity).
Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9NUM3}. Cell membrane {ECO:0000250|UniProtKB:Q9NUM3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUM3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NUM3}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUM3}. Nucleus {ECO:0000250|UniProtKB:Q9NUM3}.
Sequence: MDDFLSISLLSVAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEEVLEGKHHQTSEMKQNGIASDKAAEISSVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGSSHVHSSDDPETARPSSSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPAMSMLTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEVGGMGHSHKPDTTGGRGLSRLEVAALVLGCLIPLILSIGHQH
InterPro domains: - IPR003689: Zinc/iron permease (family) [132-302]
- IPR045891: Zinc transporter ZIP9 (family) [1-308]
Interaction partners: - Zinc transporter ZIP11
- Zinc transporter SLC39A7
- Zinc transporter 7
- Zinc transporter ZIP13
- Proton-coupled zinc antiporter SLC30A5
- Proton-coupled zinc antiporter SLC30A9, mitochondrial
- Zinc transporter ZIP1
- Zinc transporter ZIP12
- Zinc transporter 6
- Zinc transporter ZIP10
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005385 (zinc ion transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0046915 (transition metal ion transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0001775 (cell activation), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0140352 (export from cell), GO:0003008 (system process), GO:0010035 (response to inorganic substance), GO:0050878 (regulation of body fluid levels), GO:0044057 (regulation of system process), GO:0098660 (inorganic ion transmembrane transport), GO:0006810 (transport), GO:0044057 (regulation of system process), GO:0140115 (export across plasma membrane), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0003013 (circulatory system process), GO:0090066 (regulation of anatomical structure size), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0003018 (vascular process in circulatory system), GO:0051592 (response to calcium ion), GO:0098662 (inorganic cation transmembrane transport), GO:0008015 (blood circulation), GO:0048869 (cellular developmental process), GO:0006811 (monoatomic ion transport), GO:1903522 (regulation of blood circulation), GO:0035150 (regulation of tube size), GO:0097746 (blood vessel diameter maintenance), GO:0006812 (monoatomic cation transport), GO:0035296 (regulation of tube diameter), GO:0019229 (regulation of vasoconstriction), GO:0030001 (metal ion transport), GO:0060048 (cardiac muscle contraction)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)