Protein: L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (P42123)
Organism: Rattus norvegicus (Rat)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07195}; Peripheral membrane protein {ECO:0000305}.
Sequence: MATLKEKLIAPVADDETAVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCTIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVDSAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLRKSADTLWDIQKDLKDL
InterPro domains: - IPR001557: L-lactate/malate dehydrogenase (family) [19-334]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [2-161]
- IPR001236: Lactate/malate dehydrogenase, N-terminal (domain) [23-161]
- IPR022383: Lactate/malate dehydrogenase, C-terminal (domain) [165-330]
- IPR011304: L-lactate dehydrogenase (family) [21-332]
- IPR015955: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (homologous_superfamily) [162-331]
- IPR018177: L-lactate dehydrogenase, active site (active_site) [191-197]
Interaction partners: - L-lactate dehydrogenase A chain
- Aspartate aminotransferase, cytoplasmic
- Pyruvate kinase PKM
- Aspartate aminotransferase, mitochondrial
- Pyruvate kinase PKLR
- Pyruvate carboxylase, mitochondrial
- L-lactate dehydrogenase C chain
- D-lactate dehydrogenase
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- Malic enzyme
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0009628 (response to abiotic stimulus), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0014823 (response to activity), GO:0009991 (response to extracellular stimulus), GO:0001666 (response to hypoxia), GO:0007584 (response to nutrient), GO:1901698 (response to nitrogen compound), GO:0009410 (response to xenobiotic stimulus), GO:0070887 (cellular response to chemical stimulus), GO:0070482 (response to oxygen levels), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0010033 (response to organic substance), GO:0009725 (response to hormone), GO:0043434 (response to peptide hormone), GO:1901652 (response to peptide), GO:0071417 (cellular response to organonitrogen compound), GO:0032870 (cellular response to hormone stimulus), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:0031667 (response to nutrient levels), GO:0036293 (response to decreased oxygen levels), GO:1901699 (cellular response to nitrogen compound), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:1901653 (cellular response to peptide), GO:0071375 (cellular response to peptide hormone stimulus), GO:0032868 (response to insulin), GO:0032869 (cellular response to insulin stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005615 (extracellular space), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0005576 (extracellular region), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0098857 (membrane microdomain), GO:0043229 (intracellular organelle), GO:1990204 (oxidoreductase complex), GO:0043227 (membrane-bounded organelle), GO:0045121 (membrane raft), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)