Protein: Voltage-gated potassium channel KCNC4 (Potassium voltage-gated channel subfamily C member 4) (Raw3) (Voltage-gated potassium channel subunit Kv3.4) (Q63734)
Organism: Rattus norvegicus (Rat)
Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subcellular location: Membrane; Multi-pass membrane protein.
Sequence: MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGGGAGPGDEAGDDERELALQRLGPHEGGSGPGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIHRVGNITSVRFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPPQLESPIYCKSEETSPRDSTYSDTSPPAREEGMVERKRADSKQNGDANAVLSDEEGAGLTQPLASAPTPEERRALRRSGTRDRNKKAAACFLLSAGDYACADGSVQKEGSVEPKACVPVSHTCAL
InterPro domains: - IPR028325: Voltage-gated potassium channel (family) [35-513]
- IPR003974: Potassium channel, voltage dependent, Kv3 (family) [95-500]
- IPR027359: Voltage-dependent channel domain superfamily (homologous_superfamily) [206-364]
- IPR003131: Potassium channel tetramerisation-type BTB domain (domain) [38-144]
- IPR005405: Potassium channel, voltage dependent, Kv3.4 (family) [18-527]
- IPR021645: Shal-type voltage-gated potassium channels, N-terminal (domain) [5-26]
- IPR000210: BTB/POZ domain (domain) [36-152]
- IPR011333: SKP1/BTB/POZ domain superfamily (homologous_superfamily) [33-162]
- IPR003968: Potassium channel, voltage dependent, Kv (family) [94-472]
- IPR005821: Ion transport domain (domain) [227-481]
Interaction partners: - Voltage-gated potassium channel subunit beta-3
- FAU ubiquitin like and ribosomal protein S30 fusion like 2
- Ubiquitin-like protein FUBI
- Voltage-gated potassium channel subunit beta-1
- Voltage-gated potassium channel subunit beta-2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0044325 (transmembrane transporter binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0015079 (potassium ion transmembrane transporter activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0005267 (potassium channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0005249 (voltage-gated potassium channel activity), GO:0022832 (voltage-gated channel activity), GO:0005251 (delayed rectifier potassium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048856 (anatomical structure development), GO:0009628 (response to abiotic stimulus), GO:0007275 (multicellular organism development), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051050 (positive regulation of transport), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0021675 (nerve development), GO:0044093 (positive regulation of molecular function), GO:0051049 (regulation of transport), GO:0044085 (cellular component biogenesis), GO:0035556 (intracellular signal transduction), GO:0009314 (response to radiation), GO:0098660 (inorganic ion transmembrane transport), GO:0032409 (regulation of transporter activity), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0009636 (response to toxic substance), GO:0070848 (response to growth factor), GO:0034762 (regulation of transmembrane transport), GO:0034764 (positive regulation of transmembrane transport), GO:1901700 (response to oxygen-containing compound), GO:0034220 (monoatomic ion transmembrane transport), GO:0048857 (neural nucleus development), GO:0010033 (response to organic substance), GO:0010035 (response to inorganic substance), GO:0021536 (diencephalon development), GO:1901698 (response to nitrogen compound), GO:0060322 (head development), GO:0070887 (cellular response to chemical stimulus), GO:0032411 (positive regulation of transporter activity), GO:0043270 (positive regulation of monoatomic ion transport), GO:0030900 (forebrain development), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0010038 (response to metal ion), GO:0098655 (monoatomic cation transmembrane transport), GO:0009416 (response to light stimulus), GO:0097305 (response to alcohol), GO:1990089 (response to nerve growth factor), GO:0034765 (regulation of monoatomic ion transmembrane transport), GO:0021545 (cranial nerve development), GO:1901699 (cellular response to nitrogen compound), GO:0071731 (response to nitric oxide), GO:0006811 (monoatomic ion transport), GO:0019932 (second-messenger-mediated signaling), GO:0022607 (cellular component assembly), GO:0007420 (brain development), GO:0034767 (positive regulation of monoatomic ion transmembrane transport), GO:0097237 (cellular response to toxic substance), GO:0098662 (inorganic cation transmembrane transport), GO:0043268 (positive regulation of potassium ion transport), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0071241 (cellular response to inorganic substance), GO:0032414 (positive regulation of ion transmembrane transporter activity), GO:0007417 (central nervous system development), GO:0022898 (regulation of transmembrane transporter activity), GO:0043933 (protein-containing complex organization), GO:0014070 (response to organic cyclic compound), GO:0060359 (response to ammonium ion), GO:0043269 (regulation of monoatomic ion transport), GO:1901701 (cellular response to oxygen-containing compound), GO:0071805 (potassium ion transmembrane transport), GO:0006812 (monoatomic cation transport), GO:0045471 (response to ethanol), GO:0021554 (optic nerve development), GO:0065003 (protein-containing complex assembly), GO:0032026 (response to magnesium ion), GO:1904064 (positive regulation of cation transmembrane transport), GO:0014075 (response to amine), GO:0032412 (regulation of monoatomic ion transmembrane transporter activity), GO:0019935 (cyclic-nucleotide-mediated signaling), GO:0009642 (response to light intensity), GO:0010959 (regulation of metal ion transport), GO:2001259 (positive regulation of cation channel activity), GO:1902170 (cellular response to reactive nitrogen species), GO:1904062 (regulation of monoatomic cation transmembrane transport), GO:0071732 (cellular response to nitric oxide), GO:1901381 (positive regulation of potassium ion transmembrane transport), GO:0007263 (nitric oxide mediated signal transduction), GO:1901018 (positive regulation of potassium ion transmembrane transporter activity), GO:1901016 (regulation of potassium ion transmembrane transporter activity), GO:1901379 (regulation of potassium ion transmembrane transport), GO:2001257 (regulation of cation channel activity), GO:0043266 (regulation of potassium ion transport), GO:0019934 (cGMP-mediated signaling), GO:0030001 (metal ion transport), GO:0051259 (protein complex oligomerization), GO:1903818 (positive regulation of voltage-gated potassium channel activity), GO:0051260 (protein homooligomerization), GO:0051291 (protein heterooligomerization), GO:0006813 (potassium ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0043204 (perikaryon), GO:0045178 (basal part of cell), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0044304 (main axon), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:1990351 (transporter complex), GO:0031252 (cell leading edge), GO:0031256 (leading edge membrane), GO:0045177 (apical part of cell), GO:0044306 (neuron projection terminus), GO:0044298 (cell body membrane), GO:0036477 (somatodendritic compartment), GO:0030673 (axolemma), GO:0120025 (plasma membrane bounded cell projection), GO:0043679 (axon terminus), GO:0045202 (synapse), GO:0032589 (neuron projection membrane), GO:0032809 (neuronal cell body membrane), GO:0016324 (apical plasma membrane), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0009925 (basal plasma membrane), GO:0098590 (plasma membrane region), GO:1902495 (transmembrane transporter complex), GO:0097447 (dendritic tree), GO:0043195 (terminal bouton), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane), GO:0031253 (cell projection membrane), GO:0098982 (GABA-ergic synapse), GO:0034702 (ion channel complex), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0016323 (basolateral plasma membrane), GO:0031982 (vesicle), GO:0008076 (voltage-gated potassium channel complex), GO:0030424 (axon), GO:0034703 (cation channel complex), GO:0034705 (potassium channel complex)