Protein: Receptor for retinol uptake stra6 (Stimulated by retinoic acid gene 6 protein homolog) (F1RAX4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol-binding protein rbp1. Required for normal vitamin A homeostasis.
Subcellular location: Cell membrane {ECO:0000269|PubMed:27563101}; Multi-pass membrane protein {ECO:0000269|PubMed:27563101}.
Sequence: MSAETVNNYDYSDWYENAAPTKAPVEVIPPCDPTADEGLFHICIAAISLVVMLVLAILARRQKLSDNQRGLTGLLSPVNFLDHTQHKGLAVAVYGVLFCKLVGMVLSHHPLPFTKEVANKEFWMILALLYYPALYYPLLACGTLHNKVGYVLGSLLSWTHFGILVWQKVDCPKTPQIYKYYALFGSLPQIACLAFLSFQYPLLLFKGLQNTETANASEDLSSSYYRDYVKKILKKKKPTKISSSTSKPKLFDRLRDAVKSYIYTPEDVFRFPLKLAISVVVAFIALYQMALLLISGVLPTLHIVRRGVDENIAFLLAGFNIILSNDRQEVVRIVVYYLWCVEICYVSAVTLSCLVNLLMLMRSMVLHRSNLKGLYRGDSLNVFNCHRSIRPSRPALVCWMGFTSYQAAFLCLGMAIQTLVFFICILFAVFLIIIPILWGTNLMLFHIIGNLWPFWLTLVLAALIQHVASRFLFIRKDGGTRDLNNRGSLFLLSYILFLVNVMIGVVLGIWRVVITALFNIVHLGRLDISLLNRNVEAFDPGYRCYSHYLKIEVSQSHPVMKAFCGLLLQSSGQDGLSAQRIRDAEEGIQLVQQEKKQNKVSNAKRARAHWQLLYTLVNNPSLVGSRKHFQCQSSESFINGALSRTSKEGSKKDGSVNEPSKEAESAAASN
InterPro domains: - IPR026612: Receptor for retinol uptake STRA6-like (family) [29-628]
Interaction partners: - Plasma retinol-binding protein II
- Calmodulin
- Transthyretin
- Aldehyde dehydrogenase 1 family member A3
- Retinol dehydrogenase 10-B
- Cytochrome P450 26A1
- Short-chain dehydrogenase/reductase 3
- Cytochrome P450 26B1
- Spalt-like transcription factor 2.
- Beta-carotene oxygenase 1.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0005319 (lipid transporter activity), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0035265 (organ growth), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0044403 (biological process involved in symbiotic interaction), GO:0033036 (macromolecule localization), GO:0016049 (cell growth), GO:0008037 (cell recognition), GO:0007154 (cell communication), GO:0032989 (cellular component morphogenesis), GO:0010876 (lipid localization), GO:0060759 (regulation of response to cytokine stimulus), GO:0048729 (tissue morphogenesis), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009826 (unidimensional cell growth), GO:0048513 (animal organ development), GO:0009799 (specification of symmetry), GO:0060041 (retina development in camera-type eye), GO:0060419 (heart growth), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0001756 (somitogenesis), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0035239 (tube morphogenesis), GO:0035282 (segmentation), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0007224 (smoothened signaling pathway), GO:0021915 (neural tube development), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0032990 (cell part morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0060027 (convergent extension involved in gastrulation), GO:0003143 (embryonic heart tube morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0016331 (morphogenesis of embryonic epithelium), GO:0048666 (neuron development), GO:0072175 (epithelial tube formation), GO:0022607 (cellular component assembly), GO:0009855 (determination of bilateral symmetry), GO:0022008 (neurogenesis), GO:0048568 (embryonic organ development), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0003007 (heart morphogenesis), GO:0060972 (left/right pattern formation), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0007417 (central nervous system development), GO:0060429 (epithelium development), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0030182 (neuron differentiation), GO:0009952 (anterior/posterior pattern specification), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0061371 (determination of heart left/right asymmetry), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0043009 (chordate embryonic development), GO:0007368 (determination of left/right symmetry), GO:0048592 (eye morphogenesis), GO:0030903 (notochord development), GO:0001654 (eye development), GO:0048048 (embryonic eye morphogenesis), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0150063 (visual system development), GO:0001947 (heart looping), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0043010 (camera-type eye development), GO:0048593 (camera-type eye morphogenesis), GO:0007409 (axonogenesis)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0042592 (homeostatic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0045494 (photoreceptor cell maintenance), GO:0048871 (multicellular organismal-level homeostasis), GO:0007610 (behavior), GO:0010876 (lipid localization), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0048731 (system development), GO:0006810 (transport), GO:0007632 (visual behavior), GO:0016043 (cellular component organization), GO:0001894 (tissue homeostasis), GO:0060249 (anatomical structure homeostasis), GO:0006869 (lipid transport), GO:0022008 (neurogenesis), GO:0009416 (response to light stimulus), GO:0007634 (optokinetic behavior), GO:0007399 (nervous system development), GO:0035845 (photoreceptor cell outer segment organization), GO:0071702 (organic substance transport), GO:0001895 (retina homeostasis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0042461 (photoreceptor cell development), GO:0015850 (organic hydroxy compound transport), GO:0046864 (isoprenoid transport), GO:0048699 (generation of neurons), GO:0046530 (photoreceptor cell differentiation), GO:0046865 (terpenoid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0031090 (organelle membrane), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane)