Protein: Neogenin (P97603)
Organism: Rattus norvegicus (Rat)
Function: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response (By similarity).
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Sequence: AAAKNGSPPQSAGASVRTFTPLYFLVEPVDTLSVRGSSVILNCSAYSEPSPNIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLAVAGLPRFTSQPEPSSIYVGNSGILNCEVNADLVPFVRWEQNRQPLLLDDRIVKLPSGTLVISNATEGDEGLYRCIVESGGPPKFSDEAELKVLQESEEMLDLVFLMRPSSMIKVIGQSAVLPCVASGLPAPVIRWMKNEDVLDTESSGRLALLAGGSLEISDVTEDDAGTYFCVADNGNKTIEAQAELTVQVPPEFLKQPANIYARESMDIVFECEVTGKPAPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLSLEVRNSKSIVIHWQPPSSATQNGQITGYKIRYRKASRKSDVTETVVTGTQLSQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETFESDLDESRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGATFELVPTSPPKDVTVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTPKADSSDKMPNDQALGSAGKGGRLPDLGSDYKPPMSGSNSPHGSPTSPLDSNMLLVIIVSIGVITIVVVVIIAVFCTRRTTSHQKKKRAACKSVNGSHKYKGNCKDVKPPDLWIHHERLELKPIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDSQPPQQSVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYLASSQEEDSGQSLPTAHVRPSHPLKSFAVPAIPPPGPPIYDPALPSTPLLSQQALNHHLHSVKTASIGTLGRSRPPMPVVVPSAPEVQEATRMLEDSESSYEPDELTKEMAHLEGLMKDLNAITTA
InterPro domains: - IPR036116: Fibronectin type III superfamily (homologous_superfamily) [403-1022]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [24-398]
- IPR003961: Fibronectin type III (domain) [408-1023]
- IPR013098: Immunoglobulin I-set (domain) [121-396]
- IPR007110: Immunoglobulin-like domain (domain) [21-395]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [20-1028]
- IPR010560: Neogenin, C-terminal (domain) [1127-1377]
- IPR003598: Immunoglobulin subtype 2 (domain) [34-386]
- IPR003599: Immunoglobulin domain subtype (domain) [28-397]
Interaction partners: - Repulsive guidance molecule BMP co-receptor a
- Hemojuvelin
- Netrin-1
- Bone morphogenetic protein 2
- Bone morphogenetic protein receptor type-1A
- Netrin receptor UNC5B
- Focal adhesion kinase 1
- Rho guanine nucleotide exchange factor 12
- Serine/threonine-protein kinase receptor
- Netrin-3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019904 (protein domain specific binding), GO:0005102 (signaling receptor binding), GO:0008092 (cytoskeletal protein binding), GO:0030275 (LRR domain binding), GO:0035254 (glutamate receptor binding), GO:0035255 (ionotropic glutamate receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0051240 (positive regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0051094 (positive regulation of developmental process), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0050773 (regulation of dendrite development), GO:0045597 (positive regulation of cell differentiation), GO:2000026 (regulation of multicellular organismal development), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0070727 (cellular macromolecule localization), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0050803 (regulation of synapse structure or activity), GO:0051130 (positive regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0045184 (establishment of protein localization), GO:0022604 (regulation of cell morphogenesis), GO:0061001 (regulation of dendritic spine morphogenesis), GO:0050807 (regulation of synapse organization), GO:0031344 (regulation of cell projection organization), GO:0031346 (positive regulation of cell projection organization), GO:0015031 (protein transport), GO:0060284 (regulation of cell development), GO:0010720 (positive regulation of cell development), GO:0048814 (regulation of dendrite morphogenesis), GO:0050769 (positive regulation of neurogenesis), GO:0051960 (regulation of nervous system development), GO:0008104 (protein localization), GO:0010770 (positive regulation of cell morphogenesis involved in differentiation), GO:0010769 (regulation of cell morphogenesis involved in differentiation), GO:0099175 (regulation of postsynapse organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0050767 (regulation of neurogenesis), GO:0050775 (positive regulation of dendrite morphogenesis), GO:0010975 (regulation of neuron projection development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0150034 (distal axon), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0030427 (site of polarized growth), GO:0071944 (cell periphery), GO:0120025 (plasma membrane bounded cell projection), GO:0043229 (intracellular organelle), GO:0030426 (growth cone), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043005 (neuron projection), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0030424 (axon), GO:0097708 (intracellular vesicle)