Protein: Neuronal acetylcholine receptor subunit alpha-2 (P12389)
Organism: Rattus norvegicus (Rat)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular location: Synaptic cell membrane {ECO:0000250|UniProtKB:Q15822}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q15822}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [248-508]
- IPR006201: Neurotransmitter-gated ion-channel (family) [12-503]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [26-247]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [160-174]
- IPR002394: Nicotinic acetylcholine receptor (family) [70-158]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [242-505]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [249-502]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [36-241]
Interaction partners: - Neuronal acetylcholine receptor subunit alpha-7
- Neuronal acetylcholine receptor subunit beta-3
- Muscle, skeletal receptor tyrosine protein kinase
- Agrin
- Acetylcholine receptor subunit alpha
- Neuronal acetylcholine receptor subunit beta-2
- Acetylcholinesterase
- Acetylcholine receptor subunit beta
- Acetylcholine receptor subunit epsilon
- Acetylcholine receptor subunit delta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0042165 (neurotransmitter binding), GO:0050997 (quaternary ammonium group binding), GO:1901363 (heterocyclic compound binding), GO:0044877 (protein-containing complex binding), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043169 (cation binding), GO:0022803 (passive transmembrane transporter activity), GO:0030594 (neurotransmitter receptor activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0005261 (monoatomic cation channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022848 (acetylcholine-gated monoatomic cation-selective channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0099536 (synaptic signaling), GO:1901698 (response to nitrogen compound), GO:0070887 (cellular response to chemical stimulus), GO:0042391 (regulation of membrane potential), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0098926 (postsynaptic signal transduction), GO:0010033 (response to organic substance), GO:0035094 (response to nicotine), GO:1902074 (response to salt), GO:0071417 (cellular response to organonitrogen compound), GO:0051899 (membrane depolarization), GO:1905144 (response to acetylcholine), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1902075 (cellular response to salt), GO:0099537 (trans-synaptic signaling), GO:1901699 (cellular response to nitrogen compound), GO:0095500 (acetylcholine receptor signaling pathway), GO:1901701 (cellular response to oxygen-containing compound), GO:0098916 (anterograde trans-synaptic signaling), GO:1905145 (cellular response to acetylcholine), GO:0007268 (chemical synaptic transmission), GO:0007271 (synaptic transmission, cholinergic)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:1990351 (transporter complex), GO:0098794 (postsynapse), GO:0043235 (receptor complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0098802 (plasma membrane signaling receptor complex), GO:0045202 (synapse), GO:0098797 (plasma membrane protein complex), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0045211 (postsynaptic membrane), GO:0098590 (plasma membrane region), GO:1902495 (transmembrane transporter complex), GO:0098857 (membrane microdomain), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0045121 (membrane raft), GO:0099634 (postsynaptic specialization membrane), GO:0034702 (ion channel complex), GO:0098588 (bounding membrane of organelle), GO:0098690 (glycinergic synapse), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0098981 (cholinergic synapse), GO:0098984 (neuron to neuron synapse), GO:0005892 (acetylcholine-gated channel complex), GO:0044853 (plasma membrane raft), GO:0032279 (asymmetric synapse)