Protein: Replicative DNA helicase DnaB (EC 5.6.2.3) (DNA 5'-3' helicase DnaB) (O25916)
Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Function: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
Sequence: MDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFFEIALKLHEEDCPIDENFIRQKMPKDKQIKEEDLVAIFAASPIDNIEAYVEEIKNASIKRKLFGLANTIREQALESAQKSSDILGAVEREVYALLNGSTIEGFRNIKEVLESAMDLITENQRKGSLEVTGIPTGFVQLDNYTSGFNKGSLVIIGARPSMGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLALRALSDLTSINMHDLESGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKLKSQHKELGIAFIDYLQLMSGSKATKERHEQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRPILSDIKDSGGIEQDADIVLFLYRGYIYQMRAEDNKIDKLKKEGKIEEAQELYLKVNEERRIHKQNGSIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDMPIDSHLEEGQETKVDYDIVTT
InterPro domains: - IPR007693: DNA helicase, DnaB-like, N-terminal (domain) [8-102]
- IPR036185: DNA helicase, DnaB-like, N-terminal domain superfamily (homologous_superfamily) [6-111]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [151-469]
- IPR016136: DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal (homologous_superfamily) [1-122]
- IPR007692: DNA helicase, DnaB type (family) [9-467]
- IPR007694: DNA helicase, DnaB-like, C-terminal (domain) [172-471]
Interaction partners: - DNA primase
- Chromosomal replication initiator protein DnaA
- Elongation factor Tu
- Bifunctional NAD
- Sensor histidine kinase CrdS
- DNA polymerase III subunit gamma/tau
- Transcriptional regulatory protein CrdR
- DNA polymerase III subunit alpha
- Competence locus E
- Beta sliding clamp
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0006996 (organelle organization), GO:0090304 (nucleic acid metabolic process), GO:0006260 (DNA replication), GO:0051276 (chromosome organization), GO:0071103 (DNA conformation change), GO:0006261 (DNA-templated DNA replication), GO:0006268 (DNA unwinding involved in DNA replication), GO:0032392 (DNA geometric change), GO:0032508 (DNA duplex unwinding)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0140535 (intracellular protein-containing complex)