Protein: E3 ubiquitin-protein transferase MAEA (EC 2.3.2.27) (Macrophage erythroblast attacher) (E7ESC7)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
Sequence: MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKGRQNKHEAKTGRKSRAASSSPKESLDLGMETLKGKPELSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
InterPro domains: - IPR013144: CRA domain (domain) [250-344]
- IPR006595: CTLH, C-terminal LisH motif (domain) [159-254]
- IPR045098: Fyv10 family (family) [11-432]
- IPR044063: Gid-type RING finger domain (domain) [352-419]
- IPR024964: CTLH/CRA C-terminal to LisH motif domain (domain) [160-339]
- IPR006594: LIS1 homology motif (conserved_site) [121-153]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048523 (negative regulation of cellular process), GO:0007155 (cell adhesion), GO:0050794 (regulation of cellular process), GO:0060548 (negative regulation of cell death), GO:0010941 (regulation of cell death), GO:0043069 (negative regulation of programmed cell death), GO:0043067 (regulation of programmed cell death), GO:0043066 (negative regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0033033 (negative regulation of myeloid cell apoptotic process), GO:0033032 (regulation of myeloid cell apoptotic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0034399 (nuclear periphery), GO:0071944 (cell periphery), GO:0140535 (intracellular protein-containing complex), GO:0016363 (nuclear matrix), GO:0070938 (contractile ring), GO:0032153 (cell division site), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0043228 (non-membrane-bounded organelle), GO:0043233 (organelle lumen), GO:0000151 (ubiquitin ligase complex), GO:0005826 (actomyosin contractile ring), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0070013 (intracellular organelle lumen), GO:0030864 (cortical actin cytoskeleton), GO:0005634 (nucleus), GO:0005856 (cytoskeleton), GO:0031981 (nuclear lumen), GO:0005819 (spindle), GO:0015629 (actin cytoskeleton), GO:0015630 (microtubule cytoskeleton)