Protein: Kinesin-like protein KIF1C (O43896)
Organism: Homo sapiens (Human)
Function: Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}.
Sequence: MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSTEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDLFSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILGPYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVLTWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPCEGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLEMEKRLQDLENQYRKEKEEADLLLEQQRLYADSDSGDDSDKRSCEESWRLISSLREQLPPTTVQTIVKRCGLPSSGKRRAPRRVYQIPQRRRLQGKDPRWATMADLKMQAVKEICYEVALADFRHGRAEIEALAALKMRELCRTYGKPDGPGDAWRAVARDVWDTVGEEEGGGAGSGGGSEEGARGAEVEDLRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPEGSEAAEEAAPSDRMPSARPPSPPLSSWERVSRLMEEDPAFRRGRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRESWPGMGSGEAPTPLQPPEEVTPHPATPARRPPSPRRSHHPRRNSLDGGGRSRGAGSAQPEPQHFQPKKHNSYPQPPQPYPAQRPPGPRYPPYTTPPRMRRQRSAPDLKESGAAV
InterPro domains: - IPR000253: Forkhead-associated (FHA) domain (domain) [524-590]
- IPR032405: Kinesin-associated (domain) [352-522]
- IPR019821: Kinesin motor domain, conserved site (conserved_site) [242-253]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [5-358]
- IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [4-372]
- IPR008984: SMAD/FHA domain superfamily (homologous_superfamily) [498-599]
- IPR001752: Kinesin motor domain (domain) [3-356]
Interaction partners: - Tyrosine-protein phosphatase non-receptor type 21
- KIF-binding protein
- Rabankyrin-5
- Kinesin-like protein KIF1B
- Protein Hook homolog 3
- Kinesin-like protein KIF1A
- BICD family-like cargo adapter 1
- Ras-related protein Rab-6A
- Kinesin-like protein KIF13B
- Kinesin light chain 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0003777 (microtubule motor activity), GO:0005515 (protein binding), GO:0008574 (plus-end-directed microtubule motor activity), GO:0019899 (enzyme binding), GO:0044389 (ubiquitin-like protein ligase binding), GO:0031625 (ubiquitin protein ligase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0016192 (vesicle-mediated transport), GO:0048193 (Golgi vesicle transport), GO:0006890 (retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)