Protein: Somatotropin (Growth hormone) (P13391)
Organism: Oreochromis niloticus (Nile tilapia) (Tilapia nilotica)
Function: Growth hormone plays an important role in growth control and involved in the regulation of several anabolic processes.
Subcellular location: Secreted.
Sequence: MNSVVLLLSVVCLGVSSQQITDSQRLFSIAVNRVTHLHLLAQRLFSDFESSLQTEEQRQLNKIFLQDFCNSDYIISPIDKHETQRSSVLKLLSISYGLVESWEFPSRSLSGGSSLRNQISPRLSELKTGILLLIRANQDEAENYPDTDTLQHAPYGNYYQSLGGNESLRQTYELLACFKKDMHKVETYLTVAKCRLSPEANCTL
InterPro domains: - IPR018116: Somatotropin hormone, conserved site (conserved_site) [69-194]
- IPR034975: Somatotropin (family) [26-202]
- IPR001400: Somatotropin/prolactin (family) [6-202]
- IPR009079: Four-helical cytokine-like, core (homologous_superfamily) [10-202]
Interaction partners: - Growth hormone receptor
- Growth hormone receptor
- Somatolactin alpha
- Ghrelin
- Prolactin receptor
- Uncharacterized protein.
- Proopiomelanocortin.
- Prolactin
- Prolactin 2
- Mitochondrial fission regulator
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0051427 (hormone receptor binding), GO:0005126 (cytokine receptor binding), GO:0005131 (growth hormone receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:1905953 (negative regulation of lipid localization), GO:0065008 (regulation of biological quality), GO:0023056 (positive regulation of signaling), GO:1905954 (positive regulation of lipid localization), GO:0023057 (negative regulation of signaling), GO:0051051 (negative regulation of transport), GO:0051240 (positive regulation of multicellular organismal process), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0048523 (negative regulation of cellular process), GO:0051050 (positive regulation of transport), GO:0048522 (positive regulation of cellular process), GO:0046888 (negative regulation of hormone secretion), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0046887 (positive regulation of hormone secretion), GO:2000833 (positive regulation of steroid hormone secretion), GO:0032370 (positive regulation of lipid transport), GO:0010646 (regulation of cell communication), GO:1905952 (regulation of lipid localization), GO:0044057 (regulation of system process), GO:0032369 (negative regulation of lipid transport), GO:0010647 (positive regulation of cell communication), GO:0010817 (regulation of hormone levels), GO:0051048 (negative regulation of secretion), GO:1903531 (negative regulation of secretion by cell), GO:0046883 (regulation of hormone secretion), GO:1903532 (positive regulation of secretion by cell), GO:2000831 (regulation of steroid hormone secretion), GO:0051046 (regulation of secretion), GO:0044060 (regulation of endocrine process), GO:0032368 (regulation of lipid transport), GO:2000843 (regulation of testosterone secretion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)