wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Hydrogenase-1 operon protein HyaE (P19931)
Organism: Escherichia coli (strain K12)
Function: Not known. Could form, along with HyaD, a complex involved in the processing of the hydrogenase 1 structural operon
Sequence: MSNDTPFDALWQRMLARGWTPVSESRLDDWLTQAPDGVVLLSSDPKRTPEVSDNPVMIGELLREFPDYTWQVAIADLEQSEAIGDRFGVFRFPATLVFTGGNYRGVLNGIHPWAELINLMRGLVEPQQERAS
InterPro domains: - IPR036249: Thioredoxin-like superfamily (homologous_superfamily) [5-130]
- IPR010893: [NiFe]-hydrogenase maturation factor HyaE (family) [6-119]
Interaction partners: - Hydrogenase 1 maturation protease
- Hydrogenase-1 operon protein HyaF
- Hydrogenase-1 small chain
- Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
- Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit
- Hydrogenase-1 large chain
- Hydrogenase-1 large chain
- Cytochrome bd-II ubiquinol oxidase subunit 1
- Cytochrome bd-II ubiquinol oxidase subunit 2
- Hydrogenase-2 operon protein HybE
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:0016053 (organic acid biosynthetic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0006573 (valine metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Hyphally regulated cell wall protein 1 (Q5AL03)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through conferring resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin- forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
Sequence: MKVVSNFIFTILLTLNLSAALEVVTSRIDRGGIQGFHGDVKVHSGATWAILGTTLCSFFGGLEVEKGASLFIKSDNGPVLALNVALSTLVRPVINNGVISLNSKSSTSFSNFDIGGSSFTNNGEIYLASSGLVKSTAYLYAREWTNNGLIVAYQNQKAAGNIAFGTAYQTITNNGQICLRHQDFVPATKIKGTGCVTADEDTWIKLGNTILSVEPTHNFYLKDSKSSLIVHAVSSNQTFTVHGFGNGNKLGLTLPLTGNRDHFRFEYYPDTGILQLRAAALPQYFKIGKGYDSKLFRIVNSRGLKNAVTYDGPVPNNEIPAVCLIPCTNGPSAPESESDLNTPTTSSIETSSYSSAATESSVVSESSSAVDSLTSSSLSSKSESSDVVSSTTNIESSSTAIETTMNSESSTDAGSSSISQSESSSTAITSSSETSSSESMSASSTTASNTSIETDSGIVSQSESSSNALSSTEQSITSSPGQSTIYVNSTVTSTITSCDENKCTEDVVTIFTTVPCSTDCVPTTGDIPMSTSYTQRTVTSTITNCDEVSCSQDVVTYTTNVPHTTVDATTTTTTSTGGDNSTGGNESGSNHGSGAGSNEGSQSGPNNGSGSGSEGGSNNGSGSGSDSGSNNGSGSGSNNGSGSGSNNGSGSGSGSTEGSEGGSGSNEGSNHGSNEGSGSGSGSQTGSGSGSNNGSGSGSQSGSGSGSQSGSESGSNSGSNEGSNPGAGNGSNEGSGQGSGNGSEAGSGQGSGPNNGSGSGHNDGSGSGSNQGSNPGAGSGSGSESGSNAGSHSGSNEGAKTDSIEGFHTESKPGFNTGAHTDATVTGNSVANPVTTSTESDTTISVTVSITSYMTGFDGKPKPFTTVDVIPVPHSMPSNTTDSSSSVPTIDTNENGSSIVTGGKSILFGLIVSMVVLFM
InterPro domains: - IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [12-334]
Interaction partners: - Agglutinin-like protein 3
- Hyphal wall protein 1
- Extent of cell elongation protein 1
- Enhanced filamentous growth protein 1
- Cell wall protein RBT1
- Agglutinin-like protein 1
- Secreted aspartic protease 4
- Hypha-specific G1 cyclin-related protein 1
- Hyphal wall protein 2
- GPI-anchored hemophore RBT5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098743 (cell aggregation), GO:0031589 (cell-substrate adhesion), GO:0098630 (aggregation of unicellular organisms), GO:0042710 (biofilm formation), GO:0043708 (cell adhesion involved in biofilm formation), GO:0090605 (submerged biofilm formation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: ICP47 protein (P03170)
Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Function: Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes
Subcellular location: Host cytoplasm. Host nucleus
Sequence: MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR
InterPro domains: - IPR008026: Herpesvirus ICP47 (family) [1-82]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0039693 (viral DNA genome replication), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0039686 (bidirectional double-stranded viral DNA replication), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)
Protein: Insulin-like growth factor 2 mRNA-binding protein 3 (Q9PW80)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Involved in neuronal crest migration
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, P-body. Cytoplasm, Stress granule. Note=Accumulates along the vegetal cortex as oogenesis progresses. Colocalizes to extended processes in migrating neuronal crest cells
Sequence: MNKLYIGNVSEQASALDLESIFEQWKIPFSAPFLVKSGYAFVDCPDEKVAMRAIDTLSGKVELHGKVLEVEHSVPKRQRSCKLQIRNIPPHMQWEVLDGLLAQYGTVESCEQVNTDTETAVVNVRYGAKDQAREAMDKLNGFLMENYALKVSYIPDETAAADAPAVGGRRGFNPRGPPRQGSPSLGARPKLQSDVPLRLLVPTQFVGAIIGKEGATIRNITKQTHSKIDIHRKENAGAAEKPITVHSTPEGCSSACRNIMEIMQKEAIDTKITEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGTLDACAKAEEEIMKKVRESYENDVAAMHLQSNLIPGLNLNALGLFPGAASGGISPSVVSGPPPGAQAGYQSFGAQMESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPADGIDAKQRMVIISGPPEAQFKAQGRIFGKLKEENFFGPKEEVKLEAHIKVPSFAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQLAQRKIQEIISQVRRQQQPKPSAAGPPVARRK
InterPro domains: - IPR004087: K Homology domain (domain) [193-561]
- IPR035979: RNA-binding domain superfamily (homologous_superfamily) [2-156]
- IPR000504: RNA recognition motif domain (domain) [2-156]
- IPR004088: K Homology domain, type 1 (domain) [197-558]
- IPR036612: K Homology domain, type 1 superfamily (homologous_superfamily) [186-567]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [1-155]
Interaction partners: - RNA demethylase ALKBH5
- YTH domain-containing family protein
- YTH domain-containing family protein 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding), GO:0003730 (mRNA 3'-UTR binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0003407 (neural retina development), GO:0060041 (retina development in camera-type eye), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0043010 (camera-type eye development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:1990904 (ribonucleoprotein complex)
Protein: Cell wall protein IFF3 (Q5A029)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
Sequence: MQLFQNILVSIALLTQVVFAIEITENKVDRGTVTLNLSDITIYPGASWSIIDNAYTSFVGKLDVRDGAGLYISSTSHLLALQVSLTALLHSITNNGVVSFDSRISRTSSSYDLRGVSFTNNGEMYFAASGEFSSSTALTSASWTNTRLLSFYQNQRTSGTVSLGMPLGSITNNGQVCLNNQVYEQTTQIKGSGCFTANGDSTIYISNVLLAVSPKQNFYLTDKGSSMIVQAVSTTQTFNVYGFGEGNKIGLTIPLMGNLWNSAYAYDTTSGILTLRNLLLEQKFNIGTGYDPSKFQVVTDSGSGIPSTILGSVAYYGRVPERTLPKSCQIPCKPIPEAPGTTPTQYTTTITKTNTAGNTVTESGVVNVSTDKGGSWFTTTSMFPALSTAPSTATVFSSDTIMSTVEPDTTELASLTDIPIETSSVEELLSVMSNWEPSSAPTLSIETPVSSHHSSMQHSSFESSADINTVFSSESAFETASDYIVSTPSSISHSTMVPQSSVSALSVVSESLASAEPSFVVPSESFIFSASSAAPQPSSSTYSVSFTTQFETPSSAGPSLVTSVESNTELISSATQSSDIQTEFTSTWTTTNSDGSVVTESGIISQSGTSLTTLTTFQPATSLVVPPYSVIETEFTSTWTTTNSDSSVATESGVVSQSDTLLTTVTTFPPAPSAIVPEFTSPWKINTSIESSETLTVSASSYETVGESLAAATSSYLSSATVVVAPSESEINTSSSILNNEEIASAPVSDTTSIAEHHDGSLSMTTTEFVNSNSLPSSHSIVTATITSCNKSKCSESVVTYVSSVSCATITVGDSEKNSSIVGNNISSIVGDDVSNTQAITMATSTESATTLTSVSGAKPSVANDATNSVHTTDYTTATTGVQNGSSLSIPSDIPIEISDITPTDSSSSAVTISYENGSNKESIENIKYLTLVVFGLMMFM
InterPro domains: - IPR031573: GPI-anchored cell wall protein repeat (repeat) [578-693]
- IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [12-339]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Cell wall protein IFF6 (Q59XL0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
Sequence: MLLKQIFLPFFVLFNAINAIDIYQNQVSRGTIDLSIGAITIHSGAYWSIIDNAISALVGTLTVQQDAGFYITGLNPLLGLQVELLGVLNSIKNDGIVSFNGLNSLVGPIYNLVGLSFQNNGEFYLSASGVAPPVFSITAADWHNNGLLVLAQAKRTSALANLGFPTGSIENQGSICLFGTAYQQLTSITGSGCISADRDSTIYIFSSLLPIATTQTLYLADRASSIVIQPVTLPATYTVRGFGNGNKVGISLPLLSVPLLGQPAYSYDPSSGVLTLRGLGVGLLSQRFQIGTGYDSSLLEIVTDDGAGLPTTLLGSVRYNGPVPNNAVPASCNCKYVPPSPGTDESSSLSSSTSEQSSSSATSVSASETSDTSSTQESSLSSEVSSTQEPSSSTPEPSSSSETSSTQESSSTEGPSSSTDSSTEASSSESSTAPSSSAEASSSTESSTEEPSSSTEGPSSSQESSSSEESSTQEPSSSTKESSSTEGPSSTEESSSTEGPSSSTDSSTDITSASSTDEQSSSGTGQSSTEDEPIDSTESDTSSATDSSTATDSSATNTDTNSESTDSSTATDTSSTDSNTASSTETNTDVTDSSTDSNTGATESSTATDTNTDATDSSTVSETGATDSSTATDTNTGATESSTDSNTGATDSSTATDTNTSATNTDTNTGSNTATNTDDNTATDTSSTETNTATNTDGTETNTGTTETNTDTSASNTDDNTGSNTATNTGGTDTNTDTNTGGTDTNTGTNTGGTDTKTGTNTATGTNTGATETNTATNTNGNGTNTNTGATDTATNTATGTNTNTGATDTNTNTNTGATVTNTATNTGDVSATKDIPSPTSTDEGSNNGGGSNNGSGSNNGSGNGSGSGSGSGNGSGDGSNNGSGNGSDNGSGSGNGSDNGSGSGSGSDNGSGSGSGSGSGSGNGSGSGSDNGSGSGNGSGSGSGSGSGSDNGSGSGSNNGSGNGSGNGSGSGSDNGSGNGSGSGSGSGSGNGSGNGSGSGSGSGSGNGSGSNNNNGSGSGSGSGNGQDNGIITSSIGQPGSSTSTQGPSSSNSATIPEQANSGNHIKFTLFNGLLIGLVPIVFM
InterPro domains: - IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [11-341]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Cell wall protein IFF7 (Q59XB0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
Sequence: MLFTLSILSTLLFSTSISAIEITQNRVDHGTITTSIGDITIDSGAYWSIIDNSISTFIGNLDIKSNAGLYISSTISNLPLLVLLNSGSASITNDGIVSLDARTSTQGSSQFNLVGGSFENNGEFYLAASGAIPMTMGLTGKSWNNNGLIVAYQNERSSGSVKFGVIGQTITNKGQICLTNQVYQQTSKIDGSGCVTAKKNASIYISNVLDPQSVSTEQNYFLADDKSSIITQAVGFNTQVINVFGFGNGNKIGLTLPLKSGNGGQAYSYDSDSGVLSLSSGLFGQKFNIGPGYDSKLFSIVTDNSEGIPSVNNGAVSYSGPVPSQKSLPSACNVECKPVPNAPDDGSSSSSSVVSSTTSTASTDSASLSSTSGEESSASTTTTESSETSNTSSNASETNGSSTESETTGSATTSEASETINSSESSETSGASETSQSTGTSESSETESSVTESSETDSITATTSDTTSSGNDNSSVTSSSDASTDSITSETASSSSTPLSGDSSQVSSLTTGTSPDTIASFQTDSTSFGFGSGSPSSGAVQSSGVTNSTPNTGDVNTQSNTANIATSDNTATSTASNDTGVNTATATTTGTGTGPDNNNNNNNNNNNNNNNNNNNNNNNNNNTNNSGVSAADSKASGDISTVTASSTTLISVASVSSTYPIANESSSPSSSSSSSSSSSGTPGEVIPNANGSSKLSIGMTFMISGFATMFALFM
InterPro domains: - IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [11-343]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Cell wall protein IFF9 (Q5A6U1)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence
Subcellular location: Secreted, cell wall. Membrane; Lipid-anchor, GPI-anchor
Sequence: MQLFQNILVSIALLTQIVFAIEITENKVDRGTVTLNLSDITIYPGASWSIIDNAYTSFVGKLDVRDGAGLYISSTSHLLALQVSLTALLHSITNNGVVSFDSRISRTSSSYDLRGVSFTNNGEMYFAASGEFSSPTALTSASWTNTGLLSFYQNQRTSGTVSLGMPLGSITNTGQVCLNNQVYEQTTQIKGSGCFTANGDSTIYISNVLLAVSPKQNFYLTDKGSSMIVQAVSTTQTFNVYGFGEGNKIGLTIPLMGNLWNSAYAYDTTSGILTLRNLLLEQKFNIGTGYDPSKFQVVTDSGSGIPSTILGSVAYYGRVPERTLPKSCQIPCKPIPEAPGTTPTQYTTTITKTNTAGNTVTESGVVNVSTDKGGSWFTTTSMFPALSTAPSTATVFSSDTIMSTVEPDTTELASLTDIPIETSSVEELLSVMSNWEISSAPTLSIETPVSSHHSSMQHSSFESSADINTVFSSESAFETASDYIVSTPSSISHSTMVPQSSVSALSVVSESLASAEPSFVVPSESFIFSASSAAPQPSSSTYSVSFTTQFETPSSAGPSLVTSVESNTELISSATQSSDIQTEFTSTWTTTNSDGSVVTESGIISQSGTSLTTLTTFQPATSLVVPPYSVIETEFTSTWTTTNSDSSVATESGVVSQSDTLLTTVTTFPPAPSAIVPEFTSPWKINTSIESSETLTVSASSYETVGESLAAATSSYLSSATVVVAPSESEINTSSSILNNEEIASAPVSDTTSIAEHHDGSLSMTTTEFVNSNSLPSSHSIVTATITSCNKSKCSESVVTYVSSVSCATITVGDSEKNISTVGNNVSSIVGDDVSNTQAITMATSTEGATTLTSVSGAKPSVANDATNSVHTTDYTTATTGVQNGSSLSIPSDIPIEISVITPTNSSSSAITIPYENGSNKESIENIKYLALVVFGLMMFM
InterPro domains: - IPR031573: GPI-anchored cell wall protein repeat (repeat) [578-693]
- IPR021031: Hyphally-regulated cell wall protein, N-terminal (domain) [12-339]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0031589 (cell-substrate adhesion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005618 (cell wall), GO:0009277 (fungal-type cell wall)
Protein: Interferon-related developmental regulator 2 (Q12894)
Organism: Homo sapiens (Human)
Function: Ribosome-binding protein that acts as an inhibitor of mRNA translation by promoting ribosome inactivation. Associates with the P- and E-sites of the ribosome and inserts a C- terminal helix into the mRNA exit channel to preclude translation (By similarity)
Sequence: MPRARKGNTLRKGGQRRGGGARSSAQADSGSSDDEAASEARSTASECPSLLSTTAEDSLGGDVVDEQGQQEDLEEKLKEYVDCLTDKSAKTRQGALESLRLALASRLLPDFLLERRLTLADALEKCLKKGKGEEQALAAAVLGLLCVQLGPGPKGEELFHSLQPLLVSVLSDSTASPAARLHCASALGLGCYVAAADIQDLVSCLACLESVFSRFYGLGGSSTSPVVPASLHGLLSAALQAWALLLTICPSTQISHILDRQLPRLPQLLSSESVNLRIAAGETIALLFELARDLEEEFVYEDMEALCSVLRTLATDSNKYRAKADRRRQRSTFRAVLHSVEGGECEEEIVRFGFEVLYMDSWARHRIYAAFKEVLGSGMHHHLQNNELLRDIFGLGPVLLLDATALKACKVPRFEKHLYNAAAFKARTKARSRVRDKRADIL
InterPro domains: - IPR006921: Interferon-related developmental regulator, C-terminal (domain) [386-439]
- IPR016024: Armadillo-type fold (homologous_superfamily) [66-315]
- IPR011989: Armadillo-like helical (homologous_superfamily) [62-313]
- IPR007701: Interferon-related developmental regulator, N-terminal (domain) [44-341]
- IPR039777: Interferon-related developmental regulator (family) [30-441]
Interaction partners: - Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Large ribosomal subunit protein eL36
- Small ribosomal subunit protein eS7
- Large ribosomal subunit protein eL20
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL5
- Large ribosomal subunit protein uL2
- Small ribosomal subunit protein eS26
- Small ribosomal subunit protein uS2
- Small ribosomal subunit protein eS28
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0045165 (cell fate commitment), GO:0030154 (cell differentiation), GO:0061061 (muscle structure development), GO:0001709 (cell fate determination), GO:0045445 (myoblast differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Immunoglobulin heavy constant epsilon (P01854)
Organism: Homo sapiens (Human)
Function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen
Subcellular location: [Isoform 1]: Secreted
Sequence: ASTQSPSVFPLTRCCKNIPSNATSVTLGCLATGYFPEPVMVTWDTGSLNGTTMTLPATTLTLSGHYATISLLTVSGAWAKQMFTCRVAHTPSSTDWVDNKTFSVCSRDFTPPTVKILQSSCDGGGHFPPTIQLLCLVSGYTPGTINITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGLAGGSAQSQRAPDRVLCHSGQQQGLPRAAGGSVPHPRCHCGAGRADWPGPPELDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAAITLLMVQRFLSATRQGRPQTSLDYTNVLQPHA
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [6-418]
- IPR007110: Immunoglobulin-like domain (domain) [6-423]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [1-427]
- IPR050380: Immune Recognition and Response Modulators (family) [2-199]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [297-409]
- IPR003597: Immunoglobulin C1-set (domain) [22-415]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003823 (antigen binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0034987 (immunoglobulin receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)