Protein: MHC class II antigen (A0A0G4PYZ0)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Endosome membrane {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004352}.
Sequence: MVCLRLPGGSCMAVLTVTLMVLSSPLALAGDTRPRFLEYSTGECYFFNGTERVRFLDRYFYNQEEYVRFDSDVGEYRAVTELGRPSAEYWNSQKDFLEDRRALVDTYCRHNYGVGESFTVQRRVHPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKTGVVSTGLIHNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWSARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
InterPro domains: - IPR011162: MHC classes I/II-like antigen recognition protein (homologous_superfamily) [6-122]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [122-218]
- IPR050160: Major Histocompatibility Complex/Immunoglobulin (family) [25-254]
- IPR014745: MHC class II, alpha/beta chain, N-terminal (homologous_superfamily) [6-120]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [122-229]
- IPR007110: Immunoglobulin-like domain (domain) [126-214]
- IPR000353: MHC class II, beta chain, N-terminal (domain) [42-116]
- IPR003006: Immunoglobulin/major histocompatibility complex, conserved site (conserved_site) [200-206]
- IPR003597: Immunoglobulin C1-set (domain) [128-212]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005198 (structural molecule activity), GO:0003823 (antigen binding), GO:0005200 (structural constituent of cytoskeleton), GO:0030246 (carbohydrate binding), GO:0044877 (protein-containing complex binding), GO:0038023 (signaling receptor activity), GO:0033218 (amide binding), GO:0005515 (protein binding), GO:0030247 (polysaccharide binding), GO:0023023 (MHC protein complex binding), GO:0004888 (transmembrane signaling receptor activity), GO:0005102 (signaling receptor binding), GO:0042605 (peptide antigen binding), GO:0042277 (peptide binding), GO:0140375 (immune receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0002376 (immune system process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048584 (positive regulation of response to stimulus), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0002682 (regulation of immune system process), GO:0051239 (regulation of multicellular organismal process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0002253 (activation of immune response), GO:0019882 (antigen processing and presentation), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0002764 (immune response-regulating signaling pathway), GO:0019884 (antigen processing and presentation of exogenous antigen), GO:0030155 (regulation of cell adhesion), GO:0002694 (regulation of leukocyte activation), GO:0045785 (positive regulation of cell adhesion), GO:0050867 (positive regulation of cell activation), GO:0002696 (positive regulation of leukocyte activation), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0002697 (regulation of immune effector process), GO:0002504 (antigen processing and presentation of peptide or polysaccharide antigen via MHC class II), GO:0002833 (positive regulation of response to biotic stimulus), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0002699 (positive regulation of immune effector process), GO:0048002 (antigen processing and presentation of peptide antigen), GO:0050865 (regulation of cell activation), GO:0002837 (regulation of immune response to tumor cell), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0022409 (positive regulation of cell-cell adhesion), GO:0002478 (antigen processing and presentation of exogenous peptide antigen), GO:0002834 (regulation of response to tumor cell), GO:0002703 (regulation of leukocyte mediated immunity), GO:0022407 (regulation of cell-cell adhesion), GO:0002836 (positive regulation of response to tumor cell), GO:0002705 (positive regulation of leukocyte mediated immunity), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0002839 (positive regulation of immune response to tumor cell), GO:0051251 (positive regulation of lymphocyte activation), GO:0002821 (positive regulation of adaptive immune response), GO:0002495 (antigen processing and presentation of peptide antigen via MHC class II), GO:0002819 (regulation of adaptive immune response), GO:0051249 (regulation of lymphocyte activation), GO:0050870 (positive regulation of T cell activation), GO:0002822 (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0050863 (regulation of T cell activation), GO:0002824 (positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains), GO:0002708 (positive regulation of lymphocyte mediated immunity), GO:0050851 (antigen receptor-mediated signaling pathway), GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II), GO:0002706 (regulation of lymphocyte mediated immunity), GO:1903037 (regulation of leukocyte cell-cell adhesion), GO:1903039 (positive regulation of leukocyte cell-cell adhesion), GO:0046635 (positive regulation of alpha-beta T cell activation), GO:0046634 (regulation of alpha-beta T cell activation), GO:0050852 (T cell receptor signaling pathway), GO:0002711 (positive regulation of T cell mediated immunity), GO:0002709 (regulation of T cell mediated immunity), GO:2000516 (positive regulation of CD4-positive, alpha-beta T cell activation), GO:2000514 (regulation of CD4-positive, alpha-beta T cell activation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098552 (side of membrane), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0098576 (lumenal side of membrane), GO:0098791 (Golgi apparatus subcompartment), GO:0030133 (transport vesicle), GO:0098827 (endoplasmic reticulum subcompartment), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0005794 (Golgi apparatus), GO:0005773 (vacuole), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0030658 (transport vesicle membrane), GO:0000323 (lytic vacuole), GO:0030139 (endocytic vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0032588 (trans-Golgi network membrane), GO:0012506 (vesicle membrane), GO:0005770 (late endosome), GO:0005802 (trans-Golgi network), GO:0030135 (coated vesicle), GO:0098553 (lumenal side of endoplasmic reticulum membrane), GO:0005789 (endoplasmic reticulum membrane), GO:0010008 (endosome membrane), GO:0005774 (vacuolar membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0005764 (lysosome), GO:0012507 (ER to Golgi transport vesicle membrane), GO:0030666 (endocytic vesicle membrane), GO:0030134 (COPII-coated ER to Golgi transport vesicle), GO:0097708 (intracellular vesicle), GO:0031902 (late endosome membrane), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0045334 (clathrin-coated endocytic vesicle), GO:0098852 (lytic vacuole membrane), GO:0030669 (clathrin-coated endocytic vesicle membrane), GO:0030665 (clathrin-coated vesicle membrane), GO:0005765 (lysosomal membrane)