Protein: Muscarinic acetylcholine receptor M2 (P08172)
Organism: Homo sapiens (Human)
Function: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Subcellular location: Cell membrane {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}; Multi-pass membrane protein {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733}. Postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
Sequence: MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [40-440]
- IPR000995: Muscarinic acetylcholine receptor family (family) [25-457]
- IPR001065: Muscarinic acetylcholine receptor M2 (family) [7-372]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [25-455]
Interaction partners: - Beta-arrestin-1
- Proteinase-activated receptor 1
- Guanine nucleotide-binding protein G
- Lysophosphatidic acid receptor 1
- Muscarinic acetylcholine receptor M1
- Lysophosphatidic acid receptor 5
- Kininogen-1
- Lysophosphatidic acid receptor 4
- Lysophosphatidic acid receptor 6
- Lysophosphatidic acid receptor 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0060089 (molecular transducer activity), GO:0005515 (protein binding), GO:0016787 (hydrolase activity), GO:0038023 (signaling receptor activity), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0016298 (lipase activity), GO:0015464 (acetylcholine receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0099528 (G protein-coupled neurotransmitter receptor activity), GO:0042578 (phosphoric ester hydrolase activity), GO:0004930 (G protein-coupled receptor activity), GO:0016907 (G protein-coupled acetylcholine receptor activity), GO:0008227 (G protein-coupled amine receptor activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004620 (phospholipase activity), GO:0004629 (phospholipase C activity), GO:0004435 (phosphatidylinositol phospholipase C activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0007267 (cell-cell signaling), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0009719 (response to endogenous stimulus), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0051239 (regulation of multicellular organismal process), GO:0071704 (organic substance metabolic process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0099536 (synaptic signaling), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0070887 (cellular response to chemical stimulus), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0044057 (regulation of system process), GO:0071495 (cellular response to endogenous stimulus), GO:1901700 (response to oxygen-containing compound), GO:0098926 (postsynaptic signal transduction), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:1902074 (response to salt), GO:0036211 (protein modification process), GO:0071417 (cellular response to organonitrogen compound), GO:1905144 (response to acetylcholine), GO:0043412 (macromolecule modification), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0071310 (cellular response to organic substance), GO:1902075 (cellular response to salt), GO:1901699 (cellular response to nitrogen compound), GO:0095500 (acetylcholine receptor signaling pathway), GO:0090257 (regulation of muscle system process), GO:0014070 (response to organic cyclic compound), GO:1901701 (cellular response to oxygen-containing compound), GO:0006937 (regulation of muscle contraction), GO:1905145 (cellular response to acetylcholine), GO:1905145 (cellular response to acetylcholine)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)