Protein: Tyramine beta-hydroxylase (EC 1.14.17.-) (Tyramine beta-monooxygenase) (TbetaM) (Q9XTQ6)
Organism: Caenorhabditis elegans
Function: Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity.
Subcellular location: [Isoform b]: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
Sequence: MEPTASQGIQYLRGGVEWILKLLNLHILNVKHENKPLLFRLIDLKVYIPSSVSTVRWSSGASSYVILGEYRKMRSAVALLFLLVAYCGGVVHAGEIVAELYHTNVTVKWHTDYERQLVDFSIWFGASTPDVLFLGFSDFGDTNNSDVLMYYNSKKEIKDAYTNRDFKITSDLQQDFQLLRKRKDHIVVRRKLTTCDSRDYAFLPGTTQFYIAASWGSTNLVDIRDKRWVVDKKFGKVIEGPTDQPNIEEEPAALEKDVKVVIVNSNSPDPIPNVETTYKCIIRKMPFDTVNNMYHVVRMEPYVTPGNEHLVHHMEIFMCRDEVEEWSGSCNDPKKPPKSKSCSHVIAAWAMGEGPIHYPKEAGLPIGGKGKNAYVMVEIHYNNPELHKGVIDSSGFQFFVTGQLRKYDAGIMELGLIYSDANSVPPNQKAWAMNGYCPSQCTKNLPEEGINIFASQLHAHLTGRKLFTSQYRSGVRIGDVNRDEHYSPHWQHLQQLRPVVKVMPGDTLVTTCVYDTRKRSKVTFGGYRIVDEMCVNYIYYYPASDVEVCKSAISNSTLRAYFSERHGMDGKRMQISDMYSNVKDWGNGVDEEFYNVLNVGNMNMNCLKSNGEPFEFESKDSRQSWENMARPTFVSGSFITTRDRFQCPAINDMINFE
InterPro domains: - IPR005018: DOMON domain (domain) [103-214]
- IPR008977: PHM/PNGase F domain superfamily (homologous_superfamily) [259-564]
- IPR024548: Copper type II ascorbate-dependent monooxygenase, C-terminal (domain) [407-562]
- IPR000945: Dopamine beta-hydroxylase-like (family) [75-637]
- IPR028460: Tyramine beta-hydroxylase/Dopamine beta-hydroxylase (family) [129-426]
- IPR045266: Copper-dependent monooxygenases, DOMON domain (domain) [102-226]
- IPR000323: Copper type II, ascorbate-dependent monooxygenase, N-terminal (domain) [270-387]
- IPR036939: Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily (homologous_superfamily) [249-408]
- IPR020611: Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site (conserved_site) [312-319]
- IPR014784: Copper type II, ascorbate-dependent monooxygenase-like, C-terminal (homologous_superfamily) [414-569]
Interaction partners: - Chitinase-like protein C25A8.4
- Chitin-binding type-2 domain-containing protein
- DUF1525 domain-containing protein
- Peroxidase skpo-1
- Peptidase S1 domain-containing protein
- Aromatic-L-amino-acid decarboxylase
- Uncharacterized protein
- Tyrosine decarboxylase
- Aromatic-L-amino-acid decarboxylase
- Uterine Lumin Expressed/locailized
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0031090 (organelle membrane), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0009628 (response to abiotic stimulus), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0040012 (regulation of locomotion), GO:0007610 (behavior), GO:0009266 (response to temperature stimulus), GO:1901615 (organic hydroxy compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0006979 (response to oxidative stress), GO:0071495 (cellular response to endogenous stimulus), GO:0044249 (cellular biosynthetic process), GO:0006066 (alcohol metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0030537 (larval behavior), GO:0010033 (response to organic substance), GO:0007626 (locomotory behavior), GO:1901360 (organic cyclic compound metabolic process), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0050877 (nervous system process), GO:0097164 (ammonium ion metabolic process), GO:0071417 (cellular response to organonitrogen compound), GO:0050890 (cognition), GO:0097305 (response to alcohol), GO:1901362 (organic cyclic compound biosynthetic process), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:0008345 (larval locomotory behavior), GO:1901617 (organic hydroxy compound biosynthetic process), GO:0009308 (amine metabolic process), GO:0007612 (learning), GO:0007600 (sensory perception), GO:1901605 (alpha-amino acid metabolic process), GO:0018958 (phenol-containing compound metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:1901160 (primary amino compound metabolic process), GO:0010243 (response to organonitrogen compound), GO:0019751 (polyol metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0042428 (serotonin metabolic process), GO:0006576 (biogenic amine metabolic process), GO:0045471 (response to ethanol), GO:0009712 (catechol-containing compound metabolic process), GO:0007606 (sensory perception of chemical stimulus), GO:1901162 (primary amino compound biosynthetic process), GO:0042435 (indole-containing compound biosynthetic process), GO:0009309 (amine biosynthetic process), GO:0046189 (phenol-containing compound biosynthetic process), GO:0042401 (biogenic amine biosynthetic process), GO:0006584 (catecholamine metabolic process), GO:0009713 (catechol-containing compound biosynthetic process), GO:0042417 (dopamine metabolic process), GO:0042423 (catecholamine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0030054 (cell junction), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0008021 (synaptic vesicle), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0030133 (transport vesicle), GO:0043025 (neuronal cell body), GO:0043227 (membrane-bounded organelle), GO:0030658 (transport vesicle membrane), GO:0099503 (secretory vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0070382 (exocytic vesicle), GO:0043005 (neuron projection), GO:0030672 (synaptic vesicle membrane), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0097708 (intracellular vesicle), GO:0099501 (exocytic vesicle membrane)