Protein: HSP90AB1 protein (Q6PK50)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFEKKKKKK
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [1-236]
- IPR001404: Heat shock protein Hsp90 family (family) [9-350]
- IPR019805: Heat shock protein Hsp90, conserved site (conserved_site) [33-42]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [35-189]
- IPR020568: Ribosomal protein uS5 domain 2-type superfamily (homologous_superfamily) [284-349]
- IPR020575: Heat shock protein Hsp90, N-terminal (domain) [13-213]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0023057 (negative regulation of signaling), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0009892 (negative regulation of metabolic process), GO:0050793 (regulation of developmental process), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0051707 (response to other organism), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0051094 (positive regulation of developmental process), GO:0048585 (negative regulation of response to stimulus), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0044085 (cellular component biogenesis), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0002694 (regulation of leukocyte activation), GO:1903706 (regulation of hemopoiesis), GO:0001817 (regulation of cytokine production), GO:0051726 (regulation of cell cycle), GO:0009894 (regulation of catabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:1903708 (positive regulation of hemopoiesis), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0009615 (response to virus), GO:0050865 (regulation of cell activation), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0045597 (positive regulation of cell differentiation), GO:0050790 (regulation of catalytic activity), GO:0010648 (negative regulation of cell communication), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:1903829 (positive regulation of protein localization), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0044092 (negative regulation of molecular function), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0080135 (regulation of cellular response to stress), GO:0006952 (defense response), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0050867 (positive regulation of cell activation), GO:0098542 (defense response to other organism), GO:0002696 (positive regulation of leukocyte activation), GO:2000026 (regulation of multicellular organismal development), GO:0031325 (positive regulation of cellular metabolic process), GO:0010646 (regulation of cell communication), GO:0033554 (cellular response to stress), GO:0031323 (regulation of cellular metabolic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0031330 (negative regulation of cellular catabolic process), GO:0070201 (regulation of establishment of protein localization), GO:0002237 (response to molecule of bacterial origin), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0043412 (macromolecule modification), GO:0051223 (regulation of protein transport), GO:0051251 (positive regulation of lymphocyte activation), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0043933 (protein-containing complex organization), GO:0043085 (positive regulation of catalytic activity), GO:0010629 (negative regulation of gene expression), GO:0051249 (regulation of lymphocyte activation), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0060284 (regulation of cell development), GO:0051248 (negative regulation of protein metabolic process), GO:0010720 (positive regulation of cell development), GO:0032880 (regulation of protein localization), GO:1902532 (negative regulation of intracellular signal transduction), GO:0051960 (regulation of nervous system development), GO:2001020 (regulation of response to DNA damage stimulus), GO:0036211 (protein modification process), GO:0016236 (macroautophagy), GO:1902107 (positive regulation of leukocyte differentiation), GO:0051247 (positive regulation of protein metabolic process), GO:0051338 (regulation of transferase activity), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0051174 (regulation of phosphorus metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0042981 (regulation of apoptotic process), GO:0045619 (regulation of lymphocyte differentiation), GO:0050863 (regulation of T cell activation), GO:0030162 (regulation of proteolysis), GO:0065003 (protein-containing complex assembly), GO:0031400 (negative regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0045621 (positive regulation of lymphocyte differentiation), GO:0043549 (regulation of kinase activity), GO:2000059 (negative regulation of ubiquitin-dependent protein catabolic process), GO:0051345 (positive regulation of hydrolase activity), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0031401 (positive regulation of protein modification process), GO:0043409 (negative regulation of MAPK cascade), GO:0043408 (regulation of MAPK cascade), GO:0043065 (positive regulation of apoptotic process), GO:0051347 (positive regulation of transferase activity), GO:0031399 (regulation of protein modification process), GO:0019220 (regulation of phosphate metabolic process), GO:0050829 (defense response to Gram-negative bacterium), GO:0045862 (positive regulation of proteolysis), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:0045582 (positive regulation of T cell differentiation), GO:0045859 (regulation of protein kinase activity), GO:0042327 (positive regulation of phosphorylation), GO:0001934 (positive regulation of protein phosphorylation), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0033674 (positive regulation of kinase activity), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0033673 (negative regulation of kinase activity), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0051131 (chaperone-mediated protein complex assembly), GO:0031396 (regulation of protein ubiquitination), GO:0045860 (positive regulation of protein kinase activity), GO:0006469 (negative regulation of protein kinase activity), GO:0031398 (positive regulation of protein ubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0043230 (extracellular organelle), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:1903561 (extracellular vesicle)