Protein: RING-type E3 ubiquitin transferase (EC 2.3.2.27) (Q9VJ14)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MRASIPPGIRVVRGPNWIWSNQDDGEGHVGTVCEIGRCGSTHSPENTVVVNWDSGHRTNYRVGYQNQYDLIIVDNAQVGVRHSNVVCDGCSKAGIAGIVFKCAQCPNYHLCAYCYAEDLHDIEHPFIRYTTPNSLGVRLPMRKGAKRIQLRGIFVGSKVVRGPDWEWNEQDGGEGRTGRVMEIRGWDNESCRSVANVAWVTGSTNVYRLGHKGNVDLKYITATCGGHYYKDHMPVLGQTEELQPVAPMVKPSFSVGDRVKVCLEVDALMKLQQGHGGWNPRMVEHLSKLGTVHRITDKGDIRVQYENCPNRWTFHPAALVKVVSFRVGDLVTIINDANKVQQLQKGHGEWIEIMRHALGKICKVVKVYSDGDLRIQQLDDGFEWTLNPKCVKLERSPLATAAERSNSMMDLSHRRADHVMTPLSGLSGSSVADKLVREAAQGHLDFVRQYLDVNPSQVDVMSGGKACIQVASHQGYVDLVSYLISKGANVNAVDKEGDSALHYAAFGNQPATMRVLLQHGAEVNFLNSSHCSALHICAHKKTPHCVRELLQHNANVNIQDSYGDTALHDAIGKENTEVVELLCNAPNLDFTVKNNRGFNVLHHAALKGNVVAARRILLLSRQLVNVRKDDGFAALHLAALNGHAQVVETLVTEGQAELDIRNNRQQTPFLLAVSQGHAGVIERLVRLSCDVNAKDEDGDNAMHLCVIKKSNLQSAAEPQPEEAPEIHKFYLSLVHSSIRPEDRLMYSILIYLSRAGCRVELNNANASIFEWITDRHIRQLIFGQQGEAESLPRNLQALEVSAGSADGEESSASAGAESNGAGPGSVAAPPPPQRQTFELMPKPNDIPAIGVGASPSTPSASPGVKKLNSDATPQNVSPQVAPRKKAPKPPVTTSSSSTALEAGAAGPSTSPVIVPGPHECIVCNEILPMVRFEPCQHQIACEECGIRMKKCLRCAVAIERRLTVSGRVVALPTSTSSPSDPTRLPSGDLLRYLENKVLEFEESHFCGICMERKRDVAFLCGHGACSHCAETLRTCHMCRKTILKKINLY
InterPro domains: - IPR010606: Mib-herc2 (domain) [1-223]
- IPR042056: E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type (domain) [85-129]
- IPR000433: Zinc finger, ZZ-type (domain) [81-134]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [429-781]
- IPR040847: Mind bomb, SH3 repeat domain (domain) [253-391]
- IPR043145: Zinc finger, ZZ-type superfamily (homologous_superfamily) [78-131]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [915-1049]
- IPR002110: Ankyrin repeat (repeat) [439-696]
- IPR037252: Mib/herc2 domain superfamily (homologous_superfamily) [3-221]
- IPR001841: Zinc finger, RING-type (domain) [920-1039]
Interaction partners: - Ubiquitin-ribosomal protein eS31 fusion protein
- Polyubiquitin
- GH17761p
- Ubiquitin-ribosomal protein eL40 fusion protein
- Autophagy-related 8b, isoform A
- Autophagy-related 8a, isoform A
- ubiquitinyl hydrolase 1
- Caspase-8
- Ubiquitin-like domain-containing protein
- RE23139p1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007267 (cell-cell signaling), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048856 (anatomical structure development), GO:0048584 (positive regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0071704 (organic substance metabolic process), GO:0051050 (positive regulation of transport), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0045165 (cell fate commitment), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0010646 (regulation of cell communication), GO:0030154 (cell differentiation), GO:0006810 (transport), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0060627 (regulation of vesicle-mediated transport), GO:0051130 (positive regulation of cellular component organization), GO:0045807 (positive regulation of endocytosis), GO:0051128 (regulation of cellular component organization), GO:0043170 (macromolecule metabolic process), GO:0045168 (cell-cell signaling involved in cell fate commitment), GO:0036211 (protein modification process), GO:0045747 (positive regulation of Notch signaling pathway), GO:0030100 (regulation of endocytosis), GO:0043412 (macromolecule modification), GO:0008593 (regulation of Notch signaling pathway), GO:0007423 (sensory organ development), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0006897 (endocytosis), GO:0070647 (protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:0016567 (protein ubiquitination), GO:0000209 (protein polyubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0045177 (apical part of cell), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0005938 (cell cortex), GO:0099568 (cytoplasmic region), GO:0045179 (apical cortex), GO:0099738 (cell cortex region)