Protein: B-type cell cycle switch protein ccs52A (Q9M7I2)
Organism: Medicago truncatula (Barrel medic) (Medicago tribuloides)
Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Required to switch form cell proliferation to cell differentiation, endoreduplication and ploidy-dependent cell enlargement, including during nodulation, before nodule differentiation. Involved in root-knot nematode Meloidogyne incognita giant cells formation
Subcellular location: Nucleus. Note=Present in the nucleus of endoreduplication-competent cells
Sequence: MDGTGNRNPPPTSTVGDNSPPPEPSPESLRHVSRMINSNHYTSPSRTIYSDRFIPSRSASKFALFDINTPTEGRDDSSSAYTTLLRTALFGPDVAGPVTPEKTDSPSMTLPNRNIFRYKTETRQSMHSLSPFMDDDFVPGINHSPVKAPRKVPRSPYKVLDAPALQDDFYLNLVDWSSHNVLAVGLGNCVYLWNACSSKVTKLCDLGVDDCVCSVGWAQRGTHLAVGTNNGKVQIWDAARCKKIRSMEGHRLRVGALAWSSSLLSSGGRDKNIYQRDIRTQEDFVSKLSGHKSEVCGLKWSYDNRELASGGNDNKLFVWNQHSTQPVLKYCEHTAAVKAIAWSPHLHGLLASGGGTADRCIRFWNTTTNSHLSCMDTGSQVCNLVWSKNVNELVSTHGYSQNQIIVWRYPTMSKLATLTGHTYRVLYLAISPDGQTIVTGAGDETLRFWNVFPSPKSQNTESEIGALSLGRTTIR
InterPro domains: - IPR056150: CDC20/Fizzy, WD40 domain (domain) [160-449]
- IPR033010: WD repeat Cdc20/Fizzy (family) [38-458]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [157-457]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [146-455]
- IPR001680: WD40 repeat (repeat) [153-451]
- IPR019775: WD40 repeat, conserved site (conserved_site) [437-451]
Interaction partners: - Anaphase-promoting complex subunit 10
- Anaphase promoting complex protein
- Anaphase-promoting complex subunit 4
- Anaphase-promoting complex subunit 5
- Anaphase-promoting complex subunit 1
- Mitotic spindle checkpoint protein MAD2
- Anaphase-promoting complex subunit 7
- B-type cell cycle switch protein ccs52B
- Anaphase-promoting complex subunit 11
- Anaphase-promoting complex subunit 11
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0048522 (positive regulation of cellular process), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0009791 (post-embryonic development), GO:0009894 (regulation of catabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0044248 (cellular catabolic process), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0009057 (macromolecule catabolic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0030163 (protein catabolic process), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0009057 (macromolecule catabolic process), GO:0044265 (cellular macromolecule catabolic process), GO:0045862 (positive regulation of proteolysis), GO:0030162 (regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0043632 (modification-dependent macromolecule catabolic process), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0010498 (proteasomal protein catabolic process), GO:0051603 (proteolysis involved in protein catabolic process), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:1903052 (positive regulation of proteolysis involved in protein catabolic process), GO:0032434 (regulation of proteasomal ubiquitin-dependent protein catabolic process), GO:0019941 (modification-dependent protein catabolic process), GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), GO:0006511 (ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)