Protein: CDW11/WDR57 (WD repeat domain 57 (U5 snRNP specific), isoform CRA_a) (cDNA FLJ90035 fis, clone HEMBA1001878, highly similar to WD repeat protein 57) (A0MNP2)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
InterPro domains: - IPR001680: WD40 repeat (repeat) [55-357]
- IPR019775: WD40 repeat, conserved site (conserved_site) [81-314]
- IPR020472: PAC1/LIS1-like, WD-40 repeat (repeat) [124-222]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [54-357]
- IPR052234: U5 snRNP Complex Component (family) [18-357]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [59-352]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0008380 (RNA splicing), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0120114 (Sm-like protein family complex), GO:1902494 (catalytic complex), GO:0140513 (nuclear protein-containing complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0016604 (nuclear body), GO:0005654 (nucleoplasm), GO:0043229 (intracellular organelle), GO:0005681 (spliceosomal complex), GO:0043233 (organelle lumen), GO:0030532 (small nuclear ribonucleoprotein complex), GO:0071013 (catalytic step 2 spliceosome), GO:0016607 (nuclear speck), GO:0043227 (membrane-bounded organelle), GO:0097525 (spliceosomal snRNP complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0005684 (U2-type spliceosomal complex), GO:0070013 (intracellular organelle lumen), GO:0071007 (U2-type catalytic step 2 spliceosome), GO:0097526 (spliceosomal tri-snRNP complex), GO:0005682 (U5 snRNP), GO:0005634 (nucleus), GO:0031981 (nuclear lumen), GO:0046540 (U4/U6 x U5 tri-snRNP complex)