Protein: Myosin-5 (Q59MQ0)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity). Plays a role in chitin deposition in the cell wall, in determination of the budding pattern, and is required for hyphae formation
Subcellular location: Cytoplasm, cytoskeleton, actin patch. Note=Localizes to cortical patch-like structures. Enriched at sites of polarized growth, like the growing bud tip, the mother-bud neck after cytokinesis, and the hyphal tip
Sequence: MAIVKRGGRTKTKQQQVPAKSSGGGSSGGIKKAEFDITKKKEVGVSDLTLLSKITDEAINENLHKRFMNDTIYTYIGHVLISVNPFRDLGIYTLENLNKYKGRNRLEVPPHVFAIAESMYYNLKSYGENQCVIISGESGAGKTEAAKQIMQYIANVSVNQDNVEISKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFSEGNYQPIAAHITNYLLEKQRVVSQITNERNFHIFYQFTKHCPPQYQQMFGIQGPETYVYTSAAKCINVDGVDDAKDFQDTLNAMKIIGLTQQEQDNIFRMLASILWIGNISFVEDENGNAAIRDDSVTNFAAYLLDVNPEILKKAIIERTIETSHGMRRGSTYHSPLNIVQATAVRDALAKGIYNNLFEWIVERVNISLAGSQQQSSKSIGILDIYGFEIFERNSFEQICINYVNEKLQQIFIQLTLKAEQDEYVQEQIKWTPIDYFNNKVVCDLIEATRPQPGLFAALNDSIKTAHADSEAADQVFAQRLSMVGASNRHFEDRRGKFIIKHYAGDVTYDVAGMTDKNKDAMLRDLLELVSTSQNSFINQVLFPPDLLAQLTDSRKRPETASDKIKKSANILVDTLSQCTPSYIRTIKPNQTKKPRDYDNQQVLHQIKYLGLKENVRIRRAGFAYRSTFERFVQRFYLLSPATGYAGDYIWRGDDISAVKEILKSCHIPPSEYQLGTTKVFIKTPETLFALEDMRDKYWHNMAARIQRAWRRYVKRKEDAAKTIQNAWRIKKHGNQFEQFRDYGNGLLQGRKERRRMSMLGSRAFMGDYLGCNYKSGYGRFIINQVGINESVIFSSKGEILLSKFGRSSKRLPRIFIVTKTSIYIIAEVLVEKRLQLQKEFTIPISGINYLGLSTFQDNWVAISLHSPTPTTPDVFINLDFKTELVAQLKKLNPGITIKIGPTIEYQKKPGKFHTVKFIIGAGPEIPNNGDHYKSGTVSVKQGLPASSKNPKRPRGVSSKVDYSKYYNRGAARKTAAAAQATPRYNQPTPVANSGYSAQPAYPIPQQPQQYQPQQSQQQTPYPTQSSIPSVNQNQSRQPQRKVPPPAPSLQVSAAQAALGKSPTQQRQTPAHNPVASPNRPASTTIATTTSHTSRPVKKTAPAPPVKKTAPPPPPPTLVKPKFPTYKAMFDYDGSVAGSIPLVKDTVYYVTQVNGKWGLVKTMDETKEGWSPIDYLKECSPNETQKSAPPPPPPPPAATASAGANGASNPISTTTSTNTTTSSHTTNATSNGSLGNGLADALKAKKQEETTLAGSLADALKKRQGATRDSDDEEEEDDDDW
InterPro domains: - IPR036961: Kinesin motor domain superfamily (homologous_superfamily) [43-657]
- IPR036028: SH3-like domain superfamily (homologous_superfamily) [1146-1249]
- IPR001452: SH3 domain (domain) [1156-1216]
- IPR001609: Myosin head, motor domain-like (domain) [37-732]
- IPR036072: Class I myosin, motor domain (domain) [57-718]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [40-776]
- IPR010926: Class I myosin tail homology domain (domain) [789-981]
- IPR035535: Fungal myosin-I, SH3 domain (domain) [1160-1213]
- IPR054489: Myosin-1, central acidic domain (domain) [1287-1313]
Interaction partners: - Actin-binding protein
- Vrp1p
- Calmodulin
- Serine/threonine-protein kinase
- OPA3-like protein
- Mlc1p
- Regulator of cytoskeleton and endocytosis RVS167
- Actin
- Protein BZZ1
- Actin cytoskeleton-regulatory complex protein PAN1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003774 (cytoskeletal motor activity), GO:0140657 (ATP-dependent activity), GO:0005515 (protein binding), GO:0000146 (microfilament motor activity), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0040007 (growth), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0009605 (response to external stimulus), GO:0019954 (asexual reproduction), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0048583 (regulation of response to stimulus), GO:0030447 (filamentous growth), GO:0035821 (modulation of process of another organism), GO:0006950 (response to stress), GO:0044403 (biological process involved in symbiotic interaction), GO:0051707 (response to other organism), GO:0007154 (cell communication), GO:0051701 (biological process involved in interaction with host), GO:0009991 (response to extracellular stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0043207 (response to external biotic stimulus), GO:0052173 (response to defenses of other organism), GO:0042594 (response to starvation), GO:0080134 (regulation of response to stress), GO:0044003 (modulation by symbiont of host process), GO:0075136 (response to host), GO:0031668 (cellular response to extracellular stimulus), GO:0031349 (positive regulation of defense response), GO:0071496 (cellular response to external stimulus), GO:0031347 (regulation of defense response), GO:0036170 (filamentous growth of a population of unicellular organisms in response to starvation), GO:0052200 (response to host defenses), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:0052031 (modulation by symbiont of host defense response), GO:0031669 (cellular response to nutrient levels), GO:0044416 (induction by symbiont of host defense response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0061645 (endocytic patch), GO:0030427 (site of polarized growth), GO:0005933 (cellular bud), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0060187 (cell pole), GO:0051286 (cell tip), GO:0001411 (hyphal tip), GO:0043229 (intracellular organelle), GO:0005938 (cell cortex), GO:0030479 (actin cortical patch), GO:0043228 (non-membrane-bounded organelle), GO:0030863 (cortical cytoskeleton), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0030864 (cortical actin cytoskeleton), GO:0015629 (actin cytoskeleton)