Protein: ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219) (Q8K2Y0)
Organism: Mus musculus (Mouse)
Function: E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S-phase.
Subcellular location: Chromosome {ECO:0000250|UniProtKB:Q5W0B1}. Note=Association to chromatin is cell cycle-regulated, absent from mitotic chromosomes, is associated with chromatin from G1 and partially released from chromatin from mid S-phase. {ECO:0000250|UniProtKB:Q5W0B1}.
Sequence: MAQTVQNVTLSLTLPITCHICLGKVRQPVVCTNNHVFCSICIDLWLKNNSQCPACRVPITPENPCKEIIGGTSESEPMLSHTVRKHLRKTRLELLHREYEDEIDCLQKEVEELKSKNLSLESQIKTILDPLALMQGSQNEDKHPLADNPSKMDPDSVVEWKKKLRTANEIYEKVKDDVDKLKEANKKLKLENGGLLRENLRLKAEVDNRSPQKFGRFTVAALQSKVEQYERETNRLKKALERSDKYIEELESQVAHLKHSEEAKEDVDALCQRAPSADSKGPNGSDELGPPKNQSDSARKQAGSASASHLASPSSSRLADSGSVRQESTSRTEPNCPQNKDRYPKPTEPRLGARETPMDTYLEREWGSKPSDCAPYKEDELYGIPASCTPLSLSCLQLNTPENRENPVIKAGSSKKHANHLRKLVFDDFCDSPNACNNNSSEDDRRENEKKSDCFASSKTGFWDCCSTSYAQSLEFDGSEGNAIANSVGEIPSKLSEKSGSCLSKRLSCIRSLEMNRTRTSSEASMDAAYLDKISELDSMMSESDNSKSPCNNGFKSVEVEGPSKSPQGREFLEEPDKLQEGSKLNLSKPALTADGLESGGEWKPSSFFLLSPADHEMSEDFSLHSTSHSGTSEVKPPNCLFQTEFSQGALLSSSQGLFEDQRFGSSLFKISSEMQSLHSPLQSPWSAAFVPEKRSKNGNQSTKRKIQSSLANASPSKATKS
InterPro domains: - IPR035691: ORC ubiquitin ligase 1, RING finger (domain) [15-59]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [2-124]
- IPR039209: ORC ubiquitin ligase 1 (family) [1-722]
- IPR001841: Zinc finger, RING-type (domain) [18-56]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0003682 (chromatin binding), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0050794 (regulation of cellular process), GO:1903046 (meiotic cell cycle process), GO:0071704 (organic substance metabolic process), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0044238 (primary metabolic process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:1901564 (organonitrogen compound metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0019538 (protein metabolic process), GO:0048515 (spermatid differentiation), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007283 (spermatogenesis), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0051246 (regulation of protein metabolic process), GO:0007286 (spermatid development), GO:0048232 (male gamete generation), GO:0031399 (regulation of protein modification process), GO:0070647 (protein modification by small protein conjugation or removal), GO:0031401 (positive regulation of protein modification process), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0032446 (protein modification by small protein conjugation), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:0031396 (regulation of protein ubiquitination), GO:0016567 (protein ubiquitination), GO:0031398 (positive regulation of protein ubiquitination), GO:0051865 (protein autoubiquitination), GO:0006513 (protein monoubiquitination)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)