Protein: Receptor-interacting serine-threonine kinase 2 isoform 1 (A0A0S2Z4Z8)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [11-297]
- IPR017322: Receptor-interacting serine/threonine-protein kinase 2 (family) [1-540]
- IPR011029: Death-like domain superfamily (homologous_superfamily) [434-539]
- IPR001315: CARD domain (domain) [432-524]
- IPR042149: RIP2, CARD domain (domain) [438-524]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [142-154]
- IPR001245: Serine-threonine/tyrosine-protein kinase, catalytic domain (domain) [22-288]
- IPR000719: Protein kinase domain (domain) [18-294]
- IPR051681: Serine/Threonine Kinases and Pseudokinases (family) [13-298]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0046983 (protein dimerization activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0042802 (identical protein binding), GO:0019904 (protein domain specific binding), GO:0019899 (enzyme binding), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity), GO:0042803 (protein homodimerization activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0002020 (protease binding), GO:0089720 (caspase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0002376 (immune system process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0006955 (immune response), GO:0051240 (positive regulation of multicellular organismal process), GO:0002684 (positive regulation of immune system process), GO:0006807 (nitrogen compound metabolic process), GO:0051239 (regulation of multicellular organismal process), GO:0048522 (positive regulation of cellular process), GO:0009607 (response to biotic stimulus), GO:0009719 (response to endogenous stimulus), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0002253 (activation of immune response), GO:0051707 (response to other organism), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0002682 (regulation of immune system process), GO:0071704 (organic substance metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0010942 (positive regulation of cell death), GO:0032103 (positive regulation of response to external stimulus), GO:0012501 (programmed cell death), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0051098 (regulation of binding), GO:0001817 (regulation of cytokine production), GO:0002218 (activation of innate immune response), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0050778 (positive regulation of immune response), GO:0007166 (cell surface receptor signaling pathway), GO:0001819 (positive regulation of cytokine production), GO:0031349 (positive regulation of defense response), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0002764 (immune response-regulating signaling pathway), GO:0009967 (positive regulation of signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0019538 (protein metabolic process), GO:0006952 (defense response), GO:1901700 (response to oxygen-containing compound), GO:0030522 (intracellular receptor signaling pathway), GO:0043170 (macromolecule metabolic process), GO:0010033 (response to organic substance), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0050776 (regulation of immune response), GO:0002757 (immune response-activating signaling pathway), GO:0010941 (regulation of cell death), GO:1901698 (response to nitrogen compound), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0051090 (regulation of DNA-binding transcription factor activity), GO:0009889 (regulation of biosynthetic process), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:1901652 (response to peptide), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0002758 (innate immune response-activating signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043393 (regulation of protein binding), GO:0010468 (regulation of gene expression), GO:0002429 (immune response-activating cell surface receptor signaling pathway), GO:0032732 (positive regulation of interleukin-1 production), GO:0002753 (cytosolic pattern recognition receptor signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0051252 (regulation of RNA metabolic process), GO:0043085 (positive regulation of catalytic activity), GO:1901701 (cellular response to oxygen-containing compound), GO:0010467 (gene expression), GO:0051091 (positive regulation of DNA-binding transcription factor activity), GO:0071417 (cellular response to organonitrogen compound), GO:0002768 (immune response-regulating cell surface receptor signaling pathway), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0045088 (regulation of innate immune response), GO:0006508 (proteolysis), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:1901699 (cellular response to nitrogen compound), GO:0051604 (protein maturation), GO:0010628 (positive regulation of gene expression), GO:0032652 (regulation of interleukin-1 production), GO:0051099 (positive regulation of binding), GO:0006954 (inflammatory response), GO:0010243 (response to organonitrogen compound), GO:0006915 (apoptotic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:1902531 (regulation of intracellular signal transduction), GO:0051174 (regulation of phosphorus metabolic process), GO:0032092 (positive regulation of protein binding), GO:0002220 (innate immune response activating cell surface receptor signaling pathway), GO:0030162 (regulation of proteolysis), GO:0002221 (pattern recognition receptor signaling pathway), GO:0052547 (regulation of peptidase activity), GO:0045937 (positive regulation of phosphate metabolic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0051092 (positive regulation of NF-kappaB transcription factor activity), GO:0032651 (regulation of interleukin-1 beta production), GO:0051345 (positive regulation of hydrolase activity), GO:0031401 (positive regulation of protein modification process), GO:0032731 (positive regulation of interleukin-1 beta production), GO:0031399 (regulation of protein modification process), GO:0006355 (regulation of DNA-templated transcription), GO:0050851 (antigen receptor-mediated signaling pathway), GO:0019220 (regulation of phosphate metabolic process), GO:1901653 (cellular response to peptide), GO:0045862 (positive regulation of proteolysis), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0032495 (response to muramyl dipeptide), GO:0016485 (protein processing), GO:0001932 (regulation of protein phosphorylation), GO:0010952 (positive regulation of peptidase activity), GO:0052548 (regulation of endopeptidase activity), GO:1903322 (positive regulation of protein modification by small protein conjugation or removal), GO:0031638 (zymogen activation), GO:0042327 (positive regulation of phosphorylation), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0001934 (positive regulation of protein phosphorylation), GO:0002752 (cell surface pattern recognition receptor signaling pathway), GO:0042325 (regulation of phosphorylation), GO:1903320 (regulation of protein modification by small protein conjugation or removal), GO:0050852 (T cell receptor signaling pathway), GO:0097202 (activation of cysteine-type endopeptidase activity), GO:0140895 (cell surface toll-like receptor signaling pathway), GO:0033138 (positive regulation of peptidyl-serine phosphorylation), GO:0050730 (regulation of peptidyl-tyrosine phosphorylation), GO:0010799 (regulation of peptidyl-threonine phosphorylation), GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation), GO:0010950 (positive regulation of endopeptidase activity), GO:0031396 (regulation of protein ubiquitination), GO:2000116 (regulation of cysteine-type endopeptidase activity), GO:0033135 (regulation of peptidyl-serine phosphorylation), GO:0010800 (positive regulation of peptidyl-threonine phosphorylation), GO:0031398 (positive regulation of protein ubiquitination), GO:2001056 (positive regulation of cysteine-type endopeptidase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0031982 (vesicle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton)