Protein: Mitochondrial adenyl nucleotide antiporter SLC25A24 (Small calcium-binding mitochondrial carrier protein 1) (SCaMC-1) (Solute carrier family 25 member 24) (Q8BMD8)
Organism: Mus musculus (Mouse)
Function: Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix (By similarity).
Subcellular location: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MLRWLRAFVLPTAACHDAEPPTRYETLFRALDRNGDGVVDIGELQQGLQSLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEPSEIVQSLQMLGLHISEKQAELILQSIDSDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGVAGAVSRTSTAPLDRLKVMMQVHGSKSMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKLGTFERFISGSMAGATAQTFIYPMEVLKTRLAVAKTGQYSGIYGCAKKILKHEGFGAFYKGYIPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLSCGALSSTCGQLASYPLALVRTRMQAQATVEGAPQLSMVGLFQRIVSKEGVSGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVAQK
InterPro domains: - IPR002167: Solute carrier family 25 member 16-like (family) [189-452]
- IPR002067: Mitochondrial carrier protein (family) [197-412]
- IPR011992: EF-hand domain pair (homologous_superfamily) [9-169]
- IPR002048: EF-hand domain (domain) [19-157]
- IPR018247: EF-Hand 1, calcium-binding site (binding_site) [32-111]
- IPR023395: Mitochondrial carrier protein domain superfamily (homologous_superfamily) [187-471]
- IPR018108: Mitochondrial carrier protein, transmembrane region (repeat) [192-470]
Interaction partners: - Large ribosomal subunit protein eL18
- NADH-ubiquinone oxidoreductase chain 3
- NADH dehydrogenase iron-sulfur protein 3, mitochondrial
- NADH-ubiquinone oxidoreductase chain 1
- NADH-ubiquinone oxidoreductase chain 4
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:1901505 (carbohydrate derivative transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0015605 (organophosphate ester transmembrane transporter activity), GO:0043169 (cation binding), GO:0008514 (organic anion transmembrane transporter activity), GO:0015932 (nucleobase-containing compound transmembrane transporter activity), GO:0046872 (metal ion binding), GO:0015215 (nucleotide transmembrane transporter activity), GO:0005346 (purine ribonucleotide transmembrane transporter activity), GO:0005347 (ATP transmembrane transporter activity), GO:0005509 (calcium ion binding), GO:0015216 (purine nucleotide transmembrane transporter activity), GO:0000295 (adenine nucleotide transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0051649 (establishment of localization in cell), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0006839 (mitochondrial transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:0015931 (nucleobase-containing compound transport), GO:0015748 (organophosphate ester transport), GO:1901264 (carbohydrate derivative transport), GO:0015711 (organic anion transport), GO:0015867 (ATP transport), GO:0006862 (nucleotide transport), GO:0015868 (purine ribonucleotide transport), GO:0015865 (purine nucleotide transport), GO:0051503 (adenine nucleotide transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)