Protein: UDP-N-acetylglucosamine diphosphorylase 1 (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridylyltransferase 1) (UDP-N-acetylgalactosamine diphosphorylase 1) (EC 2.7.7.83) (Q940S3)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Uridylyltransferase involved in the biosynthesis of UDP-glucosamine, an essential precursor for glycoprotein and glycolipid synthesis. Can use both UDP-glucosamine and the 4-epimer UDP-galactosamine as substrates, but no other sugars or NTPs. Acts redundantly with GLCNAC1PUT2. Required for gametogenesis and embryo development.
Sequence: MIEPSMERENGALTAATTTTTAVTSPPPMASSPRQALVERLKDYGQEDIFSLWDELSPDEKDFLVRDIENLDLPRIDRIIRCSLHSQGLPVAAIEPVPENWVSTVDGRTMEDREKWWKMGLKTIYEGKLGVVLLSGGQGTRLGSSDPKGCFNIGLPSGKSLFQIQAERILCVQRLAAQVVSEGPIRPVTIHWYIMTSPFTDEATRKYFSSHKYFGLEPDQISFFQQGTLPCVTKDGKFIMETPFSLAKAPDGNGGVYAALKCSRLLEDMASRGIKYVDCYGVDNVLVRVADPTFLGYFIDKGAASAAKVVRKAYPQEQVGVFVRRGKGGPLTVVEYSELDQSMASAINQRTGRLQYCWSNVCLHMFTLDFLNQVATGLEKDSVYHLAEKKIPSMNGYTMGLKLEQFIFDSFPYAPSTALFEVLREEEFAPVKNVNGSNFDTPESARLLVLRLHTRWVIAAGGFLTHSVPLYATGVEVSPLCSYAGENLEAICRGRTFHAPCEISL
InterPro domains: - IPR029044: Nucleotide-diphospho-sugar transferases (homologous_superfamily) [29-503]
- IPR002618: UDPGP family (family) [82-447]
- IPR039741: UDP-sugar pyrophosphorylase (family) [31-500]
Interaction partners: - Phosphoacetylglucosamine mutase
- Glucosamine 6-phosphate N-acetyltransferase
- UDP-N-acetylglucosamine diphosphorylase 2
- Delta-9 desaturase-like 1 protein
- Protein PHLOEM PROTEIN 2-LIKE A10
- At3g49790
- ADP-glucose phosphorylase
- Thylakoid lumenal P17.1 protein
- Glutamine--fructose-6-phosphate aminotransferase 1
- Phosphoserine phosphatase, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity), GO:0070569 (uridylyltransferase activity), GO:0051748 (UTP-monosaccharide-1-phosphate uridylyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0009791 (post-embryonic development), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0003006 (developmental process involved in reproduction), GO:0044238 (primary metabolic process), GO:0048316 (seed development), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0048731 (system development), GO:0009790 (embryo development), GO:0048608 (reproductive structure development), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0048229 (gametophyte development), GO:0009793 (embryo development ending in seed dormancy), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0061458 (reproductive system development), GO:0009555 (pollen development), GO:0006047 (UDP-N-acetylglucosamine metabolic process), GO:0009553 (embryo sac development), GO:0006040 (amino sugar metabolic process), GO:0009225 (nucleotide-sugar metabolic process), GO:0006011 (UDP-glucose metabolic process), GO:0010154 (fruit development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)