wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Cyclic GMP-AMP synthase-like receptor 1 (cGLR1) (EC 2.7.7.-) (A1ZA55)
Organism: Drosophila melanogaster (Fruit fly)
Function: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (3',2'-cGAMP) from ATP and GTP and plays a key role in antiviral innate immunity. Synthesizes 3',2'-cGAMP in a two-step reaction through production of the linear intermediate pppA(2'-5')pG. Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses. Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',2'-cGAMP, a second messenger that binds to and activates Sting, thereby triggering the antiviral immune response via activation of the NF-kappa-B transcription factor Rel (Relish). 3',2'-cGAMP is protected from poxin cleavage.
Sequence: MAMNLENIVNQATAQYVKIKEHREPYTAHYNALKDKVYSEWKSSAVLGKLLKGSTLCGGYGDKLKVSIPDEFDLLIHLVFPENDKIIVKADASKPGNVILDMTKVMEIIGSQEHNKPVFDRLQKIVNNKKQLLEDKLNSFLESIMTQTLNKMGNQIEVAGRISHLQYKKCGPAHTIFVKGSCKYSVDFVPAIRLSAAQVVLAPEQRIHFGETLYWDAIPKPMKPAKTDNTSFTSSFYEAERRLLYGKQFLKPAIRLMKQNRNVKNKANLKSYHIKTLFLWQVIQQDPSYWSNSPKDIFIEMLGKLADSLALTPKKGKLPFFWDPKLDMFAQLTDSQRTDLYNHFRKCEYTFRKDNGNVNDCTENNVHSSFSKNTTYKL
InterPro domains: - IPR046906: Mab-21-like, HhH/H2TH-like domain (domain) [251-344]
- IPR046903: Mab-21-like, nucleotidyltransferase domain (domain) [60-246]
- IPR024810: MAB21L/Cyclic GMP-AMP synthase-like receptor (family) [59-349]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016779 (nucleotidyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0006955 (immune response), GO:0042221 (response to chemical), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0043331 (response to dsRNA), GO:0014070 (response to organic cyclic compound), GO:0043330 (response to exogenous dsRNA)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)
Protein: Metallothionein-like protein 2C (Class I metallothionein-like protein 2C) (OsMT-I-2c) (OsMT2b) (A3AZ88)
Organism: Oryza sativa subsp. japonica (Rice)
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Acts as reactive oxygen species (ROS) scavenger in the cytosol. Possesses superoxide anion and hydroxyl radical scavenging activities in vitro. Plays a role during root development, lateral root initiation and seed embryo germination, possibly by regulating levels of cytokinin.
Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:15220467}.
Sequence: MSCCGGNCGCGSGCQCGGGCGGCKMFPDVEATATTKTFVLAAPSNKASSGGMEMAVESGENGGCGCNTCKCGTSCSGCSCCSCN
InterPro domains: - IPR000347: Metallothionein, family 15, plant (family) [1-83]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0016151 (nickel cation binding), GO:0046870 (cadmium ion binding), GO:0005507 (copper ion binding), GO:0008270 (zinc ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010035 (response to inorganic substance), GO:0010038 (response to metal ion), GO:0010043 (response to zinc ion), GO:0046686 (response to cadmium ion)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Nitrogen regulatory IIA protein (PTS IIA-like nitrogen regulatory protein PtsN) (A0A0H3NI89)
Organism: Salmonella typhimurium (strain SL1344)
Function: Not known
Sequence: MINNDTTLQLSSVLNQECTRSGVHCQSKKRALEIISELAAKQLSLPPQVVFEAILTREKMGSTGIGNGIAIPHGKLEEDTLRAVGVFVQLETPIAFDAIDNQPVDLLFALLVPADQTKTHLHTLSLVAKRLADKTICRRLRAALNDEELYQIITDTEGEQNEA
InterPro domains: - IPR002178: PTS EIIA type-2 domain (domain) [12-156]
- IPR016152: Phosphotransferase/anion transporter (homologous_superfamily) [1-163]
- IPR006320: Phosphotransferase system, IIA-like nitrogen-regulatory protein PtsN (family) [9-155]
- IPR051541: PTS System Sugar Transport and Nitrogen Regulation (family) [9-158]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0065009 (regulation of molecular function), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0060255 (regulation of macromolecule metabolic process), GO:0050790 (regulation of catalytic activity), GO:0031323 (regulation of cellular metabolic process), GO:0010035 (response to inorganic substance), GO:0080090 (regulation of primary metabolic process), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0010038 (response to metal ion), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0010243 (response to organonitrogen compound), GO:0051338 (regulation of transferase activity), GO:0051052 (regulation of DNA metabolic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0043549 (regulation of kinase activity), GO:0019220 (regulation of phosphate metabolic process), GO:0031399 (regulation of protein modification process), GO:0006282 (regulation of DNA repair), GO:0042325 (regulation of phosphorylation), GO:0001932 (regulation of protein phosphorylation), GO:0045859 (regulation of protein kinase activity), GO:0071900 (regulation of protein serine/threonine kinase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)
Protein: endothelin-converting enzyme 1 (EC 3.4.24.71) (A0A8I5ZM37)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004250}. Golgi apparatus membrane {ECO:0000256|ARBA:ARBA00004194}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004194}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
Sequence: MVEYKRAKLQDEELPEVTVEGRAIQDSLEVGSQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVQYHRDPVHSTCITEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQAILKHLLENSTFNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIGGWNITGPWDEDNFMEVLKAVAGTYRAAPFFTVYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEKVLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTLAPSMDWLEFLSFLLSPLELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW
InterPro domains: - IPR000718: Peptidase M13 (family) [55-752]
- IPR018497: Peptidase M13, C-terminal domain (domain) [540-751]
- IPR008753: Peptidase M13, N-terminal domain (domain) [103-489]
- IPR042089: Peptidase M13, domain 2 (homologous_superfamily) [129-535]
- IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [92-752]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0042445 (hormone metabolic process), GO:0065008 (regulation of biological quality), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0016486 (peptide hormone processing), GO:0043603 (amide metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0010817 (regulation of hormone levels), GO:0043170 (macromolecule metabolic process), GO:0051604 (protein maturation), GO:0006518 (peptide metabolic process), GO:0006508 (proteolysis), GO:0010467 (gene expression), GO:0016485 (protein processing), GO:0140448 (signaling receptor ligand precursor processing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: Utrophin (A0A1W2P6H3)
Organism: Mus musculus (Mouse)
Function: Not known
Sequence: MSSLAATTFRWKKWRLDLPGQVPLQACRRSPDEHNDVQKKTFTKWINARFSKVSKMLVDFTV
InterPro domains: - IPR001589: Actinin-type actin-binding domain, conserved site (conserved_site) [38-47]
- IPR036872: CH domain superfamily (homologous_superfamily) [21-62]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0071840 (cellular component organization or biogenesis), GO:0032989 (cellular component morphogenesis), GO:0000902 (cell morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0016043 (cellular component organization), GO:0006935 (chemotaxis), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0030030 (cell projection organization), GO:0007399 (nervous system development), GO:0097485 (neuron projection guidance), GO:0032990 (cell part morphogenesis), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:0048666 (neuron development), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0007411 (axon guidance), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Colipase (D5FQ08)
Organism: Meleagris gallopavo (Wild turkey)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: GLIFNLDTGELCVQSAQCKSGCCQRDSGLSLARCSLKAAETQDCSRKSLYGVYYKCPCESGLSCDADWSIVGSITNTDYGVCYDKRDPTSR
InterPro domains: - IPR047576: Colipase, chordates (family) [1-84]
- IPR001981: Colipase (family) [1-90]
- IPR017913: Colipase, N-terminal (domain) [1-38]
- IPR017914: Colipase, C-terminal (domain) [41-84]
- IPR017915: Colipase, conserved site (conserved_site) [50-58]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0030234 (enzyme regulator activity), GO:0140677 (molecular function activator activity), GO:0008047 (enzyme activator activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0031647 (regulation of protein stability), GO:0050821 (protein stabilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: Serine/threonine protein kinase PK9 (EC 2.7.11.1) (Q8IEG4)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MYLGSIKNFEDDFLCKGEYKQVYLSLEQNENNEAIEIDICCDNNIYDILQFCREKYGIYGEYIIDSCGNVIHSIKDIIDGDTLYLKEKKEDMNFFSKIKNNFIVNDYIVEKRIGSGGFGIVFQGVHIQTKQKVALKFIPKSNFLDVTDVHRVFIEIQTLRGLIHNNIIKMYDVNHFQNYVCLIMEYAINGDLKNYIKNKFNGFLSEKEAHDLFLQIVKGVYYCHSKHIVHRDLKLENILLDEKMTCKIADFGLSDFVNVDQNIKTEAGTKAYIAPEIIFNQTINYSVFKLDIWSLGILLFIMTQGFAPFKYMEKELKNFESNTLNYANDISDDLKDLISLMLNVDPNKRPIIVEILNHRWFENYKES
InterPro domains: - IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [92-364]
- IPR017441: Protein kinase, ATP binding site (binding_site) [113-136]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [228-240]
- IPR000719: Protein kinase domain (domain) [107-361]
Interaction partners: - Protein phosphatase PPM5, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0005515 (protein binding), GO:0004672 (protein kinase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0004674 (protein serine/threonine kinase activity), GO:0016301 (kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:0006796 (phosphate-containing compound metabolic process), GO:0043412 (macromolecule modification), GO:0016310 (phosphorylation), GO:0006468 (protein phosphorylation), GO:0046777 (protein autophosphorylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: dihydrolipoyllysine-residue succinyltransferase (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (Q8IEA6)
Organism: Plasmodium falciparum (isolate 3D7)
Function: Not known
Sequence: MTKNLVFRLNKSLLHHVKSFNRTFLNHKYNSNANIEGSLKRYFSIETIKVPRLGDSITEGTINEWKKKVGDYVKADETITIIDTDKVSVDINSKVSGGLSKIFADVGDVVLVDAPLCEIDTSVEPPEDICKTKEEVGESKNNENNYTFNQLNRDIKDEAHIKDEVSKNEKDIFVKDPICFGNDYESINERTERRVRMLPIRKRIAERLKESQNTCALLTTFNECDMSKAMLLRSELNDIFQKKYSCKLGFVSLFMYASTLALKKMPNVNAYIENDEIVYKNYIDISVAVATPNGLTVPVIRNCQNKNLPQLELALSDLATKARSNKLSIDDFSGGTFTISNGGVFGSMLSTPIINMPQSAILGMHTIKNRPVVVNNEIVIRPIMYLALTYDHRLLDGREAVQFLCAIRDYIENPNLMLIDC
InterPro domains: - IPR000089: Biotin/lipoyl attachment (domain) [45-120]
- IPR006255: Dihydrolipoamide succinyltransferase (family) [47-420]
- IPR050537: 2-oxoacid dehydrogenase (family) [45-420]
- IPR001078: 2-oxoacid dehydrogenase acyltransferase, catalytic domain (domain) [190-418]
- IPR023213: Chloramphenicol acetyltransferase-like domain superfamily (homologous_superfamily) [184-418]
- IPR011053: Single hybrid motif (homologous_superfamily) [43-128]
Interaction partners: - 2-oxoglutarate dehydrogenase E1 component
- Dihydrolipoyl dehydrogenase
- Dihydrolipoyl dehydrogenase, apicoplast
- Succinate--CoA ligase subunit beta, mitochondrial
- Succinate--CoA ligase subunit alpha, mitochondrial
- 3-methyl-2-oxobutanoate dehydrogenase
- 2-oxoisovalerate dehydrogenase subunit alpha
- Pyruvate dehydrogenase E1 component subunit beta
- Acetyl-CoA acetyltransferase, putative
- Glycine cleavage system H protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006520 (amino acid metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006082 (organic acid metabolic process), GO:0043436 (oxoacid metabolic process), GO:0009081 (branched-chain amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: 5'-AMP-activated protein kinase subunit beta-1 (Q8IGW5)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MGNASSSVHMQRERHKSTDLSTPSSPAHFRDSIGGGGAGQGGSAGAAALGAAAGAVGAAGGGGGGGGGQAFSFDKKHTAVLNEGSSQEDDDPYYAGTGTGSTRRGTAHDDATSAVTRDHSSMDNNEEEEEAAVGAEPATGSQLTGDEDDIRKTALPTVLRWDGGGKNVTISGTFSDWKPMAMVRSHQNFVTIIDLPEGDHQYKFCVDGEWKHDPKLKSVENAEGQRNNLVSVRESDFEVFQALAKDSENVTNYAEKEYSQEVPQVKPWEKVSGPPVLPPHLLQVILNKDTPLSCEPTLLPEPNHVMLNHLYALSIKDGVMVLSATHRYRKKYVTTLLYKPI
InterPro domains: - IPR037256: ASC domain superfamily (homologous_superfamily) [251-341]
- IPR006828: Association with the SNF1 complex (ASC) domain (domain) [251-341]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [155-247]
- IPR050827: CRP1/MDG1 DNA-binding & kinase subunit (family) [1-341]
- IPR032640: AMP-activated protein kinase, glycogen-binding domain (domain) [156-237]
- IPR014756: Immunoglobulin E-set (homologous_superfamily) [156-238]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0042592 (homeostatic process), GO:0007163 (establishment or maintenance of cell polarity), GO:0019725 (cellular homeostasis), GO:0030011 (maintenance of cell polarity), GO:0061245 (establishment or maintenance of bipolar cell polarity), GO:0070050 (neuron cellular homeostasis), GO:0035088 (establishment or maintenance of apical/basal cell polarity), GO:0035090 (maintenance of apical/basal cell polarity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:1902494 (catalytic complex), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0140535 (intracellular protein-containing complex), GO:0043233 (organelle lumen), GO:1990234 (transferase complex), GO:0043229 (intracellular organelle), GO:0031588 (nucleotide-activated protein kinase complex), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0061695 (transferase complex, transferring phosphorus-containing groups), GO:0031981 (nuclear lumen), GO:0005634 (nucleus), GO:1902911 (protein kinase complex)
Protein: Eyes absent homolog (EC 3.1.3.48) (F1LX86)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MEDTQDLNEQSVKKTCPESDVSEPQNSRSMEMQDLASPHALVGGSDTPGSSKLDKSGLSSTSVTTNGTGGDNMTVLNTADWLLSCNTPSSATMSLLAVKTEPLHSSETTTTTGDGALDTFTGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPAYDLGVMLPAIKTESGLPQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTSSSTSTYQLQESLQGLTSQPGEFDTVQSPSTPIKDLDDRTCRSSGSKSRGRGRKNNPSPPPDSDLERVFVWDLDETIIVFHSLLTGSYAQKYGKDPPMAVTLGLRMEEMIFNLADTHLFFNDLEECDQVHIDDVSSDDNGQDLSTYSFATDGFHATASSANLCLPTGVRGGVDWMRKLAFRYRRVKELYNTYKNNVGGLLGPAKRDAWLQLRAEIEGLTDSWLTNALKSLSIISTRSNCVNVLVTTTQLIPALAKVLLYSLGGAFPIENIYSATKIGKESCFERIMQRFGRKVVYVVIGDGVEEEQAAKKHNMPFWRISSHSDLLALHQALELEYL
InterPro domains: - IPR038102: EYA domain superfamily (homologous_superfamily) [369-639]
- IPR042577: EYA domain, metazoan (domain) [368-639]
- IPR028472: Protein phosphatase EYA (family) [107-639]
- IPR006545: EYA domain (domain) [369-638]
Interaction partners: - SIX homeobox 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0048513 (animal organ development), GO:0048839 (inner ear development), GO:0007423 (sensory organ development), GO:0043583 (ear development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)