Protein: FLYWCH transcription factor 1 (Q9XWR1)
Organism: Caenorhabditis elegans
Function: Probable transcription factor. Binds to the DNA sequence motif 5'-[AG]GGCGCCG-3' in the promoters of target genes, including micro-RNA genes, in order to repress expression, and acting redundantly with flh-2.
Sequence: MYSPESMNSNISSPSPPSSSSLNAPSLADAPEVRSDDGEAETSEPSTSVTAVPMEIVSQASTSAPVNQLLASGIDMSSVIKNNAVLQALLASASAGGFGDNAGLTMSKLLTAALANGSTAVAKRDAGSPRTDIPKKTRLKVFSNGFFMTFDKLSSCQKKYFWRCEYKNTCKARMHTDIVTEKILTFIHEHNHSAPIDEEVRLYGLDPTNIERNRVYIVGNVADPNQRRKIRKQVADREAAAKRLVQQQEEEQQKQQSASSIVAARAAYAQAMQNGSIPTSSGVASFLQSTSATAPMTSHSMLLAQMPFLNNIKTEMSNMVKNEQFTPERYTQHMSPNLPLQTATIAPLIIPTENYDSPSYRQPAIKRKATDLTNEEHDLRRDPMFQPTFELARKLRKLWKGEPNRYPRTTTTPTHHFEFFLSKNDGTDEHLYVPMRINLRDEAHLKEALQDFCGQQCIGMLLFGISPKISVMFNQPMLNNWDNNQFFLLDISNPSRWRLMYVDDQAV
InterPro domains: - IPR052887: FLYWCH-type zinc finger-containing protein (family) [7-506]
- IPR007588: Zinc finger, FLYWCH-type (domain) [134-192]
Interaction partners: - Alpha-soluble NSF attachment protein
- RRM domain-containing protein
- HMG box domain-containing protein
- UBR-type domain-containing protein
- Nuclear hormone receptor family member nhr-111
- BTB and MATH domain-containing protein 42
- FLYWCH transcription factor 3
- REPS homolog
- Syntaxin-1A homolog
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009892 (negative regulation of metabolic process), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0009791 (post-embryonic development), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0002164 (larval development), GO:0080090 (regulation of primary metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0051252 (regulation of RNA metabolic process), GO:0002119 (nematode larval development), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:1902679 (negative regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903507 (negative regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045892 (negative regulation of DNA-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)