Protein: Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2) (Q60838)
Organism: Mus musculus (Mouse)
Function: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.
Subcellular location: Cell membrane {ECO:0000269|PubMed:17199046, ECO:0000269|PubMed:20947020}; Peripheral membrane protein {ECO:0000269|PubMed:20947020}; Cytoplasmic side {ECO:0000269|PubMed:20947020}. Cytoplasm, cytosol {ECO:0000269|PubMed:21189423}. Cytoplasmic vesicle {ECO:0000269|PubMed:17199046, ECO:0000269|PubMed:21189423}. Nucleus {ECO:0000250|UniProtKB:O14641}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization (PubMed:21189423). Localizes to cytoplasmic puncta. Interaction with FOXK1 and FOXK2 induces nuclear translocation (By similarity). {ECO:0000250|UniProtKB:O14641, ECO:0000269|PubMed:21189423}.
Sequence: MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPPAHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMVVMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM
InterPro domains: - IPR036034: PDZ superfamily (homologous_superfamily) [244-360]
- IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [418-550]
- IPR003351: Dishevelled protein domain (domain) [107-263]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [12-91]
- IPR015506: Dishevelled-related protein (family) [13-734]
- IPR038207: DIX domain superfamily (homologous_superfamily) [12-93]
- IPR000591: DEP domain (domain) [433-507]
- IPR008341: Dishevelled-2 (family) [96-668]
- IPR001158: DIX domain (domain) [11-93]
- IPR008339: Dishevelled family (family) [342-501]
- IPR001478: PDZ domain (domain) [267-355]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [407-507]
- IPR024580: Dishevelled C-terminal (domain) [515-726]
Interaction partners: - Axin-1
- Vang-like protein 2
- Vang-like protein 1
- Low-density lipoprotein receptor-related protein 6
- Dapper homolog 1
- Segment polarity protein dishevelled homolog DVL-1
- Disheveled-associated activator of morphogenesis 1
- Axin-2
- Glycogen synthase kinase-3 beta
- Prickle-like protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0060090 (molecular adaptor activity), GO:0030674 (protein-macromolecule adaptor activity), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0040007 (growth), GO:0048519 (negative regulation of biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0040011 (locomotion), GO:0048856 (anatomical structure development), GO:0007163 (establishment or maintenance of cell polarity), GO:0051240 (positive regulation of multicellular organismal process), GO:0007389 (pattern specification process), GO:0071840 (cellular component organization or biogenesis), GO:0051239 (regulation of multicellular organismal process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009892 (negative regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0048869 (cellular developmental process), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0048589 (developmental growth), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0042330 (taxis), GO:0008283 (cell population proliferation), GO:0006807 (nitrogen compound metabolic process), GO:0051241 (negative regulation of multicellular organismal process), GO:0045927 (positive regulation of growth), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0016049 (cell growth), GO:0008219 (cell death), GO:0023051 (regulation of signaling), GO:0051093 (negative regulation of developmental process), GO:0007165 (signal transduction), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0001775 (cell activation), GO:0032879 (regulation of localization), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0001763 (morphogenesis of a branching structure), GO:0051094 (positive regulation of developmental process), GO:0040008 (regulation of growth), GO:0044238 (primary metabolic process), GO:0032989 (cellular component morphogenesis), GO:0061351 (neural precursor cell proliferation), GO:0030010 (establishment of cell polarity), GO:0035148 (tube formation), GO:0060560 (developmental growth involved in morphogenesis), GO:0072089 (stem cell proliferation), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0006725 (cellular aromatic compound metabolic process), GO:0044087 (regulation of cellular component biogenesis), GO:0048588 (developmental cell growth), GO:0060411 (cardiac septum morphogenesis), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0009790 (embryo development), GO:0072006 (nephron development), GO:0051128 (regulation of cellular component organization), GO:0006935 (chemotaxis), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0021675 (nerve development), GO:0045597 (positive regulation of cell differentiation), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0021987 (cerebral cortex development), GO:0044093 (positive regulation of molecular function), GO:1903829 (positive regulation of protein localization), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0021537 (telencephalon development), GO:0046483 (heterocycle metabolic process), GO:0060341 (regulation of cellular localization), GO:0008285 (negative regulation of cell population proliferation), GO:0001558 (regulation of cell growth), GO:0009799 (specification of symmetry), GO:0044249 (cellular biosynthetic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0003151 (outflow tract morphogenesis), GO:2000026 (regulation of multicellular organismal development), GO:0042127 (regulation of cell population proliferation), GO:0010941 (regulation of cell death), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0045596 (negative regulation of cell differentiation), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0099177 (regulation of trans-synaptic signaling), GO:0080090 (regulation of primary metabolic process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0048729 (tissue morphogenesis), GO:0012501 (programmed cell death), GO:0060548 (negative regulation of cell death), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0051961 (negative regulation of nervous system development), GO:0048731 (system development), GO:0003279 (cardiac septum development), GO:0001708 (cell fate specification), GO:0046620 (regulation of organ growth), GO:0060419 (heart growth), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0009887 (animal organ morphogenesis), GO:1901360 (organic cyclic compound metabolic process), GO:0002027 (regulation of heart rate), GO:0030900 (forebrain development), GO:0072028 (nephron morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0051128 (regulation of cellular component organization), GO:0051962 (positive regulation of nervous system development), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0048639 (positive regulation of developmental growth), GO:0009967 (positive regulation of signal transduction), GO:1903530 (regulation of secretion by cell), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0046887 (positive regulation of hormone secretion), GO:0061138 (morphogenesis of a branching epithelium), GO:0051130 (positive regulation of cellular component organization), GO:0030307 (positive regulation of cell growth), GO:0031324 (negative regulation of cellular metabolic process), GO:0009880 (embryonic pattern specification), GO:0045165 (cell fate commitment), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0006139 (nucleobase-containing compound metabolic process), GO:0060322 (head development), GO:0010646 (regulation of cell communication), GO:0009889 (regulation of biosynthetic process), GO:0003206 (cardiac chamber morphogenesis), GO:0060711 (labyrinthine layer development), GO:0060562 (epithelial tube morphogenesis), GO:0030030 (cell projection organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0048103 (somatic stem cell division), GO:0001944 (vasculature development), GO:0021545 (cranial nerve development), GO:0035272 (exocrine system development), GO:0050678 (regulation of epithelial cell proliferation), GO:0060993 (kidney morphogenesis), GO:0048538 (thymus development), GO:0010468 (regulation of gene expression), GO:2000177 (regulation of neural precursor cell proliferation), GO:0061387 (regulation of extent of cell growth), GO:0001501 (skeletal system development), GO:0042692 (muscle cell differentiation), GO:0072359 (circulatory system development), GO:0072164 (mesonephric tubule development), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0007507 (heart development), GO:0060840 (artery development), GO:0003281 (ventricular septum development), GO:0003018 (vascular process in circulatory system), GO:0021983 (pituitary gland development), GO:0060562 (epithelial tube morphogenesis), GO:0031344 (regulation of cell projection organization), GO:0019438 (aromatic compound biosynthetic process), GO:0060284 (regulation of cell development), GO:0051248 (negative regulation of protein metabolic process), GO:0050804 (modulation of chemical synaptic transmission), GO:0032880 (regulation of protein localization), GO:2001020 (regulation of response to DNA damage stimulus), GO:0072175 (epithelial tube formation), GO:0003209 (cardiac atrium morphogenesis), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0022008 (neurogenesis), GO:0050770 (regulation of axonogenesis), GO:0051254 (positive regulation of RNA metabolic process), GO:0050770 (regulation of axonogenesis), GO:0060562 (epithelial tube morphogenesis), GO:0060972 (left/right pattern formation), GO:0006915 (apoptotic process), GO:0031326 (regulation of cellular biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0030054 (cell junction), GO:0098794 (postsynapse), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0045202 (synapse), GO:0043228 (non-membrane-bounded organelle), GO:0043197 (dendritic spine), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0098685 (Schaffer collateral - CA1 synapse), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0012506 (vesicle membrane), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0030135 (coated vesicle), GO:0098984 (neuron to neuron synapse), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0032279 (asymmetric synapse), GO:0097708 (intracellular vesicle), GO:0005856 (cytoskeleton), GO:0030136 (clathrin-coated vesicle), GO:0030662 (coated vesicle membrane), GO:0030424 (axon), GO:0044309 (neuron spine), GO:0030665 (clathrin-coated vesicle membrane)