Protein: Zinc cluster transcription factor CZF1 (Q5A0W9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor of beta-glucan synthesis, thus negatively regulating cell wall integrity. Plays a role in adherence, invasion and damage to oral epithelial cells.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
Sequence: MSSIPNINWNDPNNGKSNTSRQSQPQPQLPSNVSPPNSRAVPTSGSIGGPQYGSSQFSNEYSRNPNTIGGPPFPLQSNQRGYMPNTGYPVQQTAQQRSGDKLQQVHSQQQQQQQQPLYQQYPPQSVGYLAGDVYNPQHQEYVQMNQLPNQHYNLQQRQQAQGQQLKSQLNEQNAMMSASTQQYPVQDFTNPYPNAQNPAEQQQQQQPLRTQSQQWDGYQSQPLYSAAGNTIPSSIQQQIPPQNLSPSEQQQVKQQQPSPPEQGTKKKPGRKPKLRKLSESSSETPQVPKTASSSSSSPTAVNSGKPITKRSRMGCLTCRQRKKRCCETRPRCTECTRLRLNCTWPKPGTEHKNKPKDQKDDENTIEHAEFGRIKVLRGIVEYRSK
InterPro domains: - IPR036864: Zn(2)-C6 fungal-type DNA-binding domain superfamily (homologous_superfamily) [305-370]
- IPR001138: Zn(2)Cys(6) fungal-type DNA-binding domain (domain) [309-353]
Interaction partners: - Nucleoporin NSP1
- Enhanced filamentous growth protein 1
- White-opaque regulator 1
- White-opaque regulator 3
- Wor4p
- Nucleoporin
- GTP-binding nuclear protein
- Transcriptional regulator of filamentous growth FLO8
- Transcriptional repressor TUP1
- Pre-mRNA-processing factor 17
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0009607 (response to biotic stimulus), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0030447 (filamentous growth), GO:0006950 (response to stress), GO:0045927 (positive regulation of growth), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0040008 (regulation of growth), GO:0009892 (negative regulation of metabolic process), GO:0009991 (response to extracellular stimulus), GO:0002831 (regulation of response to biotic stimulus), GO:0044182 (filamentous growth of a population of unicellular organisms), GO:0032103 (positive regulation of response to external stimulus), GO:0036180 (filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0042594 (response to starvation), GO:0033554 (cellular response to stress), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0010570 (regulation of filamentous growth), GO:0060255 (regulation of macromolecule metabolic process), GO:0032101 (regulation of response to external stimulus), GO:0031668 (cellular response to extracellular stimulus), GO:0090033 (positive regulation of filamentous growth), GO:0060258 (negative regulation of filamentous growth), GO:0071496 (cellular response to external stimulus), GO:1900430 (positive regulation of filamentous growth of a population of unicellular organisms), GO:1900434 (regulation of filamentous growth of a population of unicellular organisms in response to starvation), GO:0009267 (cellular response to starvation), GO:0031667 (response to nutrient levels), GO:1900445 (positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0032106 (positive regulation of response to extracellular stimulus), GO:1900428 (regulation of filamentous growth of a population of unicellular organisms), GO:1900443 (regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus), GO:0031669 (cellular response to nutrient levels), GO:0032104 (regulation of response to extracellular stimulus), GO:0010468 (regulation of gene expression), GO:0032109 (positive regulation of response to nutrient levels), GO:0032107 (regulation of response to nutrient levels), GO:1900436 (positive regulation of filamentous growth of a population of unicellular organisms in response to starvation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)