Protein: GPI mannosyltransferase 4 (Q5A0L9)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Sequence: MIKINFNWRTFYLLTIVFRFVFTLSDSYIHPDEHFQSLEVLTNRILNYSTNIPWEFQDDPARSLAPLYFIYGPLLYFIKFFKLNLTALQIWYIARLQISILSWIITDFCLYWMLPSKPERIKAIFFTSTSYITLVYQNHLFSNSIETLLLLVTILLIDDLRYVQESKDQDVQNLNKNKNLFYTGVLISLGIFNRITFPAFLILPGWFVMKYVLKHYVSGLYLVMGFFSTTALLILVDTILFGNINNVVAEPFNVSSYIIAPLNNLLYNARYENLAQHGIHPYYTHILVNMPQILGPGLIFFVSKSYTKTTPFLTVISGLLFLSVIPHQELRFLIPLLPLACCSFDFTLKWVQPWMLYTWYIFNIFMSILMGKLHQGGVVPVLDHIKSEASVQVWWRTYTPPSWILGSNSTETTHLGEKLNDNKFINIVDCMGADSKEVQQILQTISTNKPVYLITPIASFKHFDESRFSPVWNYTFHLDLDHLDFADIQPGLGVYQLL
InterPro domains: - IPR005599: GPI mannosyltransferase (family) [10-477]
Interaction partners: - GPI ethanolamine phosphate transferase 3
- GPI mannosyltransferase 3
- GPI-anchor transamidase
- Glycosylphosphatidylinositol anchor biosynthesis protein 11
- GPI mannosyltransferase 2
- GPI mannosyltransferase 1
- GPI ethanolamine phosphate transferase 1
- GPI ethanolamine phosphate transferase 2
- Phosphatidylinositol N-acetylglucosaminyltransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016757 (glycosyltransferase activity), GO:0016758 (hexosyltransferase activity), GO:0000030 (mannosyltransferase activity), GO:0000026 (alpha-1,2-mannosyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006629 (lipid metabolic process), GO:0019538 (protein metabolic process), GO:0019637 (organophosphate metabolic process), GO:0044255 (cellular lipid metabolic process), GO:0044249 (cellular biosynthetic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:0036211 (protein modification process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0009059 (macromolecule biosynthetic process), GO:0043412 (macromolecule modification), GO:0046486 (glycerolipid metabolic process), GO:0006644 (phospholipid metabolic process), GO:0006643 (membrane lipid metabolic process), GO:0090407 (organophosphate biosynthetic process), GO:1903509 (liposaccharide metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0046467 (membrane lipid biosynthetic process), GO:0042157 (lipoprotein metabolic process), GO:0008610 (lipid biosynthetic process), GO:0045017 (glycerolipid biosynthetic process), GO:0006650 (glycerophospholipid metabolic process), GO:0006497 (protein lipidation), GO:0008654 (phospholipid biosynthetic process), GO:0006664 (glycolipid metabolic process), GO:0046474 (glycerophospholipid biosynthetic process), GO:0009247 (glycolipid biosynthetic process), GO:0042158 (lipoprotein biosynthetic process), GO:0006506 (GPI anchor biosynthetic process), GO:0006661 (phosphatidylinositol biosynthetic process), GO:0006505 (GPI anchor metabolic process), GO:0046488 (phosphatidylinositol metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)