Protein: DNA primase (EC 2.7.7.-) (F5HIN0)
Organism: Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Function: Essential component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs.
Subcellular location: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04011}. Note=Requires the presence of the primase associated factor to properly localize in the host cell nucleus. {ECO:0000255|HAMAP-Rule:MF_04011}.
Sequence: METTYRREALTVRVIFCTSGDSAETIADVLTGAPTSASFFSVLHDLFYSQILAPRVTLKLCLPARRPGNGTRCSPVLVLRTDASVASGFLGGRPLEASDIKYMLLSDQTAGLFKPLLEIIGGARAPPNQDACTFQSQVAWLRTKFVTALRKLYKMTPSPYWMLSAFGAQEAQFVLTSSFYFFEHTVVCTTETVSHLSRLFSPQQGQTLVSVTSHEELGQLYGTSPFRRRVPAFVAYVKEKLARDSLETEAIDRTIDQIRGKLMLSNQDLVHFIYISFYQCLNKRAFLRYSRQTSSSSALRELGEDPQLCGALHGEFRDHVQSYYHKKTYLSTYIDIRYVGGVLPDGYFGGSLVGERCVYWCGQSKDTASLLATISQQVPHLRLQNEFAGMLDVAALRGSDDGQFKEGLFSHSQALPLYRCEFLGKQFFTMLQEDGLERYWEQSVIFPGDQDWDMLSDKDLTYRIFYHDLSLSLPTLKEQLLVSRHEYFNPRLPVYRWVLDFDLPVCRDIDRTFEEVHSLCCSLREAILDIIQLLGPVDPRTHPVYFFKSACPPDEWRGEDVASTSFCRCHDKLGMRIIVPFPEGVCVVGSEPMVALTGILNRTIKLDPELVHRFPSIQKKGGPFDCGIYGRGRSVRLPHCYKVGLVGELCRLLKILVCHPAPNGKAQYVRRAFTLRELLHHSPGHSAGHVGRIIYSIMDRNENFLENKTISYLPAKIPHIFQRIETLSGRSIEDWLHSAVWDKAYDTICKFFPDEKAQQFSHVAFTQQGENIIQLRPRQGRHFLCINHNHKNKSKTVRVFLTLHSIRVSEVTVTLMSQCFASKCNNNVPTAHFSFVVPVGLAS
InterPro domains: - IPR033685: DNA primase (family) [11-841]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0016032 (viral process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0019058 (viral life cycle), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0019079 (viral genome replication), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0039693 (viral DNA genome replication), GO:0006139 (nucleobase-containing compound metabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006259 (DNA metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0039686 (bidirectional double-stranded viral DNA replication), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0090304 (nucleic acid metabolic process), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0071897 (DNA biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0018995 (host cellular component), GO:0043657 (host cell), GO:0033643 (host cell part), GO:0033646 (host intracellular part), GO:0043656 (host intracellular region), GO:0033647 (host intracellular organelle), GO:0033648 (host intracellular membrane-bounded organelle), GO:0042025 (host cell nucleus)