wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Steroid 21-hydroxylase (A0A8M9NZM6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Sequence: MCFSVVSVVLLLFILWMLVVKFRRQSHRRTDGVAKENNKPEAVFPKLLHSLYKLFFSTVSPTISGPRSLPLLGNMLDLAQDHLPIHLTALAKCYGNIYRLNCGSTTMVVLNNSEIIREALVKKWSDFAGRPHSYTGDIVSRGGRTISLGDFSEEWKAHRRVTHSALQRCTTDSLHSVIEKQAQHLCQVLRDYSGKAVDLSEDFTVASSNVITTLTFSKAYDKSSAELQKLQECLNEIVSLWGSPWISALDSFPLLRKFPNPPFSRLMKEVARRDELIGKHIEEFKKSEHKEGGTLTSSLLKCLEPQQGAANHTTLTDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPEVQDKVYEELCCMLDVRHPQYSDRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNSSIAGHFIPKNTIIIPNLYGAHHDPEVWDDPYSFKPERFLEGGGGSLRSLIPFGGGARLCLGEAVAKMEMFLFTAYLLREFKFLPASKEEPLPELRGVASVVLKVKPYTVIAHPREQ
InterPro domains: - IPR017972: Cytochrome P450, conserved site (conserved_site) [458-467]
- IPR036396: Cytochrome P450 superfamily (homologous_superfamily) [57-522]
- IPR001128: Cytochrome P450 (family) [64-515]
- IPR002401: Cytochrome P450, E-class, group I (family) [91-488]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0004497 (monooxygenase activity), GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen), GO:0008395 (steroid hydroxylase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0019748 (secondary metabolic process), GO:0071704 (organic substance metabolic process), GO:0046483 (heterocycle metabolic process), GO:0009404 (toxin metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901376 (organic heteropentacyclic compound metabolic process), GO:0043385 (mycotoxin metabolic process), GO:0046222 (aflatoxin metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Cerebral dopamine neurotrophic factor (A4QNW4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MSLTSSFSTPLLLLLCAVLLTVTDAEECEVCVGFLGRLYNSLVIRHTELSPELVEEGLIRACAETTGKENRLCYYLGASSDSAAKVTGEVIRPLSAHVPVHKICQRLQRRDGQICELRYERLVLDWSTDALSKMRALELKRVLASWGEECRACLEKSEFIALIQEVAPKHSASEHRAHTEEF
InterPro domains: - IPR045333: ARMET-like (family) [3-178]
- IPR045332: ARMET, N-terminal (domain) [27-122]
- IPR019345: ARMET, C-terminal (domain) [129-170]
- IPR036361: SAP domain superfamily (homologous_superfamily) [124-181]
Interaction partners: - X-box-binding protein 1
- Neuroplastin a
- Activating transcription factor 6
- B-cell lymphoma/leukemia 10
- Ankyrin repeat domain-containing protein 45
- Brain-derived neurotrophic factor
- Prosaposin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:0008289 (lipid binding), GO:0051861 (glycolipid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0022008 (neurogenesis), GO:0030182 (neuron differentiation), GO:0007399 (nervous system development), GO:0071542 (dopaminergic neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005576 (extracellular region), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Tumor protein D52 (A0A0R4IDA7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MEENDKGTQRPDFIQEVGEEAVDAAPCSPCTVLTEQEQAELHSELQKVEEEIQTLSQVLAAKEKQVAEIKRKLGITPLNELKQNLSKGWHDVTTSTAYKKTSETLSQVGQKATTAFSSVGTAITRKLEDVRLQSFSNSFGIRSIQHSASMPVMRNTPSFKSFEEKVETLKTKMSPKPSTSDIEEVSDSTPDGEPMIKQPDDTFSPDQQPH
InterPro domains: - IPR007327: Tumour protein D52 (family) [11-186]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0046983 (protein dimerization activity), GO:0042803 (protein homodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0001775 (cell activation), GO:0045321 (leukocyte activation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0046649 (lymphocyte activation), GO:0030097 (hemopoiesis), GO:0042110 (T cell activation), GO:0002521 (leukocyte differentiation), GO:0030098 (lymphocyte differentiation), GO:1903131 (mononuclear cell differentiation), GO:0030217 (T cell differentiation), GO:0033077 (T cell differentiation in thymus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0048471 (perinuclear region of cytoplasm), GO:0005737 (cytoplasm)
Protein: Zgc:136465 (Q1RM47)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Endoplasmic reticulum lumen
Sequence: MAMAPVLNICVVLFFSILAVSCDVGDIVQEQRSESPESQGTDCGCQGLKREVSVGVSDVNTLDHHDDANIYSKTANEGPDKTESDVRSKLVLLQGGWFLMGTDDPGIPQDGEGPQRKVKLDAFYIEEHEVTNQQFQHFTNQTGYITEAERFGDSFVFEGLLSEEVKSTLSHAVAAAPWWSPVKGADWRHPEGPDSTIHNRMNHPALHVSWDDARAYCQWAKRRLPTEAEWELACRGGLQDRCISVMSFPANGFGLYDMVGNAWEWTADWWTVHHSAEDKLNPKGPESGTDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCASDVDS
InterPro domains: - IPR051043: Sulfatase Modifying Factor and Kinase (family) [77-333]
- IPR042095: Sulfatase-modifying factor enzyme superfamily (homologous_superfamily) [74-334]
- IPR005532: Sulfatase-modifying factor enzyme-like domain (domain) [89-330]
- IPR016187: C-type lectin fold (homologous_superfamily) [89-333]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity), GO:0016667 (oxidoreductase activity, acting on a sulfur group of donors), GO:0016670 (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0043687 (post-translational protein modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Myocardial zonula adherens protein (A0A8M9Q8W7)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Sequence: MLQNGMVGANSTTATTEIQDLNERRIRRLRLTLRPDDSPKTPNDSVNSGEKVVNGTWKKKNGLMQRERPPGRESPQPEDKHLVTNGIGREQSAQNGPRVYGVVQSSGTNQQQEVMAREWSVNQLRDEMRYIREVRDSLEKVRERMYGQFGGMQQSMQKLTQDLKAANSHKRYLESEVKTRRAAMESFDQMNNSLISANIDLQKSLLESCNNRVGNRDEMKTLRSAMEKTEEKLKETERQLAAAQAENRTLKHQVETSQEANTQALKELSAKLQREYEEQLQEQQRKYREEIEALQAQLDDYMKRLEEAEKNAQIAEAKIAERDQRIAEVERLLNCMAQEKGDLIKKLCDCEQRLRGLDETDHADKAAAKQSEQLKGEAAELRERIKHLNDMVFSQQRKVKAMIEEVESLRAKVAQKDMFITELLDRIAIVECENNELEDKLKYFMSIQKASEIKVSTRDIGVGCDLPVRSEEPPYVAPFQPNHVSSAPRSSSRLSNSLLKYTPGQYSTMLRSTVVHTQETMTSTTQTAPPSSLHGQSMHEGSESESPAASEVSSSISPRARTSPSQVYTPFMRLMEMSAKMNIE
InterPro domains: - IPR051375: Tuftelin/GRINL1A/MYZAP/CCD68 (family) [25-503]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0030030 (cell projection organization), GO:0022607 (cellular component assembly), GO:0044782 (cilium organization), GO:0070925 (organelle assembly), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060271 (cilium assembly), GO:0120031 (plasma membrane bounded cell projection assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005815 (microtubule organizing center), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0043229 (intracellular organelle), GO:0036064 (ciliary basal body), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0043228 (non-membrane-bounded organelle), GO:0005929 (cilium), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005856 (cytoskeleton), GO:0015630 (microtubule cytoskeleton)
Protein: Pannexin (A0A8M6YTH1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Structural component of the gap junctions and the hemichannels
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi- pass membrane protein
Sequence: MQNILEQNLDMATALLAGEKLKELIMPGSTQDEKGGVLAGLMVQLKLELPFDRVVTIGTVIIPILLVTLVFTRNFAEESIYCYTPHNFTRDQALYARGYCWTELRDAVPGVDPELRPSLFEHKFLPYALLAFAGIMYIPALGWEFMASTRLTSELNFLLQEIDNCYHRAAEGRAPKIEKQIQSKGPGITERERREIIENAEKEKSPEQNLFEKYLERRGQSNFLAKLYLARHLAIICLSSIPITYLSAYYARQRQNEFTCALGGPPDTSSIPELRLNVNCKLPAVQLQRIMAAVDIALLCTMNLIILLNLLHLFVVRKSNFVFDKLHKVGIKTRRRWQKSPFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNHDATPTVRDSGIQTIDPSMDPSVLGVGELGGEPSVIKRPRKKMKWIPTSNPLPQSFKEPLTLTRLENSIKAEKPKPVRRKNVADSIIAPLLDSKSTQYPPTSKDTYNTQKKHSLNLSLDVHPYMLTIQKAETVNPEPPPVEHSISSVYIEGPHTVVHVSSTLTEKKESPPLSTTTAFSTATLPTNSYLNGGTASMPPPLDSPKVIGPLNQETEPESQPVPFSRNPSLPLLSIHHTLYEKDEDDQNRRLARPGELIAAGEC
InterPro domains: - IPR039099: Pannexin (family) [11-477]
- IPR000990: Innexin (family) [43-416]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0015267 (channel activity), GO:0022829 (wide pore channel activity), GO:0005243 (gap junction channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0006950 (response to stress), GO:0002931 (response to ischemia)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0031982 (vesicle), GO:0043231 (intracellular membrane-bounded organelle), GO:0097708 (intracellular vesicle)
Protein: Semaphorin-2A (B8JMB1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted
Sequence: MVFEAKRLTERTWCCSVIMAMVLLAWLLPLITSATPFPRDLQPISVVGLDDSYLYPSFQGLVSSNETERLGLDYQRMMRIQHMLYIAARDHVFVVNLTTAVDEIIPQQILTWRSTDVSKCTVRGRNSDECYNYIKVLVPRNDETLFACGTNALNPACRNYRLSSLEQVGQELLGQARCPFESRQSNVGVFAGGHFYSATVTDFQASDAVIYRSLGGEGRPVLRTVKYDSKWLREPHFLHAVEYGNYVYFFFSEIAVEHTAAGKVVYSRVARVCKNDNGGSTRVLDRHWTSFLKARLNCSVPGDTFFYFDVLQSLTNVLQINQRPAVVGVFTTQTNSIPGSAVCGFYLDDIERVFNGRFKEQKNSDSMWTAVPEEQVPKPRPGSCAGEGSASSYSSSVQFPDSVLSFIKTHPLMEESVPSVNSQPLITNTASSYKLTQIVVDTAAGPHKNRTVVFLGSEDGRVLKILTNTHTNSSHTSQLLEDIDVFNPTRCVGERAVLGLELDKEHHALFVAFSSCVIRVPLSRCAQHATCRRRCLYTHDPYCIWLRTGRCADMAPGFKAGFEQDIDGEQTHLFDTCTDVMSSAGSDVKSAVDSASGVKQLPDADSLSDGYHFTLLGACVLLAFVLGAIASGLLVSCYCRQSSPSTPEPEATLAHTHAHTLSLSSLAKINLLMDNKPEKKSESPSAHIYSPAKPPEELPPTPDSTPELPIKNIKAISSQWERSHTHNSTLQLIPTNQSHPMLSENHSDDISSSSQRFDATLMSPAGLKSYNRTLLPKSYYSCLKEPSECSTLQQIPEQPSAQRHVLIKMGNGITSARQHTFNPKMNSNTGNIYEIQRPLVAGGSCLTRQHSYSEPPQLQRSAIVRRTASLKPQIPPKPLNIPAKTLPSAGTHNHTHNY
InterPro domains: - IPR001627: Sema domain (domain) [39-522]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [33-524]
- IPR027231: Semaphorin (family) [23-804]
- IPR036352: Sema domain superfamily (homologous_superfamily) [65-528]
Interaction partners: - Plexin-A4
- Plexin-A2
- Plexin A3
- Neural cell adhesion molecule L1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030215 (semaphorin receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0009790 (embryo development), GO:0048598 (embryonic morphogenesis), GO:0016477 (cell migration), GO:0007369 (gastrulation), GO:0001667 (ameboidal-type cell migration), GO:0042074 (cell migration involved in gastrulation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043235 (receptor complex)
Protein: Interleukin 10 receptor, beta (A0A8M1N7Q2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response. Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another. The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes
Subcellular location: Cell membrane; Single-pass membrane protein
Sequence: MEECALLLLLLGAAASTGLSPPQNLGLQTLNTQYVLHWDWPGNQSAVNQSVRFTAQYMSEFRSRRAEHMQKWLTVCEDVEEQRCDFTHAGLFYLGIYLLRVRANTREQASNWTQISFCPDKHAALGPPSSVTLRSVRGVLEMVMADPLSSTNESMKTLVQDMYYLIQYWRQADDTRQAKELRTPNNLVVLPDLARWSVYCVRVQSRYDFENKSSVFSDTHCAQTEGQTAVWLILLYFLLALVLVFLLVLLLFLCSYRTFQTFKSVCRPSAQLPAHIQELWLSDADTPQILLSKECVCEHMDVALVCAVDTHIPEEPQDSGGSSSDTHSSGDSGVYSEEDSATHTHSHSLSLKNTHTHDHTLLLTDTL
InterPro domains: - IPR015373: Interferon/interleukin receptor domain (domain) [124-225]
- IPR036116: Fibronectin type III superfamily (homologous_superfamily) [19-224]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [19-228]
- IPR003961: Fibronectin type III (domain) [6-112]
- IPR050650: Type II Cytokine and Tissue Factor Receptors (family) [7-345]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0038023 (signaling receptor activity), GO:0140375 (immune receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0004896 (cytokine receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0072001 (renal system development), GO:0030097 (hemopoiesis), GO:0001822 (kidney development), GO:0048793 (pronephros development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Stromelysin-3 (A0A8M9Q3Z2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence: MRVSGLLACAFALHVLLTARCLPLHGGQGLAKHKESPGLSYIPHLHSEKRRGRVPHPQDTFKPPAWPKEEPHINTPLRNSSRATGPKRCGVPDYPEQRDVHLRQKRYVLFGGRWPKTDLTYKIQRFPWQMREDKVRRIFQEALKVWSDVTPLTFTEVVNQEADIVIDFTRYWHGDNLPFDGPGGILAHAFFPRTHREGDIHFDYDESWTVGNELGTDLLQVAAHEFGHVLGLQHSLVPGAIMSPFYSFSYPLKLSEDDKKGIQYLYGPPVRAQPQIPAETNDIPSAFPPDACHTDFDAVSIIRGELFFFKASYAWRIRDGRLQAGYPALASRHWSGIPQKIDAAYEDKKGNIWFFEGSNYWVFDAEHRIKGPDSLLSLGLRVSNIQAALRVKEHHSQHTYFFKSGNYWRLDPQENRVDTSAPRRIQQDWWGVPEEIDAAFQEASGFVVFISRRQYWKFDPVQRKVLEGYPRYIGADFFGCNMP
InterPro domains: - IPR024079: Metallopeptidase, catalytic domain superfamily (homologous_superfamily) [78-272]
- IPR018487: Hemopexin-like repeats (repeat) [289-480]
- IPR018486: Hemopexin, conserved site (conserved_site) [330-440]
- IPR001818: Peptidase M10, metallopeptidase (domain) [113-267]
- IPR021190: Peptidase M10A (family) [84-481]
- IPR000585: Hemopexin-like domain (domain) [289-480]
- IPR036375: Hemopexin-like domain superfamily (homologous_superfamily) [285-482]
- IPR033739: Peptidase M10A, catalytic domain (domain) [113-267]
- IPR006026: Peptidase, metallopeptidase (domain) [110-268]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0008233 (peptidase activity), GO:0008237 (metallopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0040011 (locomotion), GO:0002376 (immune system process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0048870 (cell motility), GO:0042221 (response to chemical), GO:0050900 (leukocyte migration), GO:0042330 (taxis), GO:0097529 (myeloid leukocyte migration), GO:0006935 (chemotaxis), GO:0030595 (leukocyte chemotaxis), GO:0070887 (cellular response to chemical stimulus), GO:0016477 (cell migration), GO:1905517 (macrophage migration), GO:0060326 (cell chemotaxis), GO:0048246 (macrophage chemotaxis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: Short transient receptor potential channel 4b isoform X1 (A0A0R4IM91)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence: MSQLYFRRTDNSSYRDRIPLRIVRAESELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQDEANNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSKRKETFGTLGRRAAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMKGNRKSTRANKSDTSASDVSHPEGSLQYSSALKQNSKLHLYDVTTALQQQNSEEAKASLGCLANGSAVVLTEPILKDKARSDFPKDFTDFGLFPKKQNPNKIYSLAEEATESDPDILDWGKEDKPLAGKVEQDVNESKCLMEEDERVLEEQEMEHIASSHEH
InterPro domains: - IPR002153: Transient receptor potential channel, canonical (family) [9-785]
- IPR002110: Ankyrin repeat (repeat) [39-173]
- IPR005821: Ion transport domain (domain) [376-631]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [20-305]
- IPR013555: Transient receptor ion channel domain (domain) [176-238]
Interaction partners: - Calmodulin
- Transient receptor potential cation channel subfamily V member 1
- Stromal interaction molecule 1 isoform X1
- Transient receptor potential cation channel subfamily V member 6 isoform X1
- SEC14 domain and spectrin repeat-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0006810 (transport), GO:0006811 (monoatomic ion transport), GO:0006812 (monoatomic cation transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:1990351 (transporter complex), GO:1902495 (transmembrane transporter complex), GO:0005886 (plasma membrane), GO:0034702 (ion channel complex), GO:0034703 (cation channel complex), GO:0034704 (calcium channel complex)
Protein: Tetraspanin (Q7SXT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence: MSPPSARLQTKPVITCLKTFLISYSLIFWFTGVILLAVGVWGKVNLEFDLLVNSEHGTNAPYVLIGTGAVIIIFGLFGCFATCRGSPWMLKLYAMFLVLVFLAELVAGISGFIFRHEIKAVLKGAYQKAESNYMGKDDEDLDRIQRTLQCCGEENYTSWANTTYFEKEGIPKSCCNVTASVNCTSAELKDLKKADSVVYHQGCFSLMSTTMEANLGIIAGISFGIAFFQVIGIFLACCLSRYITNNQYEMV
InterPro domains: - IPR008952: Tetraspanin, EC2 domain superfamily (homologous_superfamily) [112-214]
- IPR018503: Tetraspanin, conserved site (conserved_site) [68-90]
- IPR018499: Tetraspanin/Peripherin (family) [17-241]
- IPR048232: Tetraspanin-6/7, EC2 domain (domain) [112-215]
- IPR000301: Tetraspanin, animals (family) [11-248]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0065008 (regulation of biological quality), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:0051128 (regulation of cellular component organization), GO:0060627 (regulation of vesicle-mediated transport), GO:0099149 (regulation of postsynaptic neurotransmitter receptor internalization), GO:0051049 (regulation of transport), GO:0030100 (regulation of endocytosis), GO:0048259 (regulation of receptor-mediated endocytosis), GO:0002090 (regulation of receptor internalization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)