wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Transcription factor bHLH167 (Basic helix-loop-helix protein 167) (AtbHLH167) (bHLH 167) (bHLH transcription factor bHLH167) (F4I4E1)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Sequence: MGRAREIGEGNSSSLREQRNLREKDRRMRMKHLFSILSSHVSPTRKLPVPHLIDQATSYMIQLKENVNYLKEKKRTLLQGELGNLYEGSFLLPKLSIRSRDSTIEMNLIMDLNMKRVMLHELVSIFEEEGAQVMSANLQNLNDRTTYTIIAQAIISRIGIDPSRIEERVRKIIYGYIYFEA
InterPro domains: - IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [14-64]
- IPR015660: Achaete-scute transcription factor-related (family) [14-171]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [9-86]
Interaction partners: - At2g18210
- Large ribosomal subunit protein uL11z
- At5g20030
- Cinnamyl alcohol dehydrogenase 8
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0006970 (response to osmotic stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0010035 (response to inorganic substance), GO:0080090 (regulation of primary metabolic process), GO:0006979 (response to oxidative stress), GO:0010033 (response to organic substance), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0009651 (response to salt stress), GO:0042542 (response to hydrogen peroxide), GO:0051252 (regulation of RNA metabolic process), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0000302 (response to reactive oxygen species), GO:0010468 (regulation of gene expression), GO:0031326 (regulation of cellular biosynthetic process), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: J protein JJJ1 (P53863)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Not known
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MKTCYYELLGVETHASDLELKKAYRKKALQYHPDKNPDNVEEATQKFAVIRAAYEVLSDPQERAWYDSHKEQILNDTPPSTDDYYDYEVDATVTGVTTDELLLFFNSALYTKIDNSAAGIYQIAGKIFAKLAKDEILSGKRLGKFSEYQDDVFEQDINSIGYLKACDNFINKTDKLLYPLFGYSPTDYEYLKHFYKTWSAFNTLKSFSWKDEYMYSKNYDRRTKREVNRRNEKARQQARNEYNKTVKRFVVFIKKLDKRMKEGAKIAEEQRKLKEQQRKNELNNRRKFGNDNNDEEKFHLQSWQTVKEENWDELEKVYDNFGEFENSKNDKEGEVLIYECFICNKTFKSEKQLKNHINTKLHKKNMEEIRKEMEEENITLGLDNLSDLEKFDSADESVKEKEDIDLQALQAELAEIERKLAESSSEDESEDDNLNIEMDIEVEDVSSDENVHVNTKNKKKRKKKKKAKVDTETEESESFDDTKDKRSNELDDLLASLGDKGLQTDDDEDWSTKAKKKKGKQPKKNSKSTKSTPSLSTLPSSMSPTSAIEVCTTCGESFDSRNKLFNHVKIAGHAAVKNVVKRKKVKTKRI
InterPro domains: - IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [332-384]
- IPR054076: Zuotin-like, zuotin homology domain (domain) [178-261]
- IPR013087: Zinc finger C2H2-type (domain) [338-578]
- IPR036869: Chaperone J-domain superfamily (homologous_superfamily) [1-79]
- IPR001623: DnaJ domain (domain) [3-70]
- IPR022755: Zinc finger, double-stranded RNA binding (domain) [338-363]
- IPR051964: Multifunctional chaperone and stress response protein (family) [1-586]
- IPR018253: DnaJ domain, conserved site (conserved_site) [47-66]
Interaction partners: - Cytoplasmic 60S subunit biogenesis factor REI1
- Probable metalloprotease ARX1
- Diphthamide biosynthesis protein 4
- Pre-mRNA-splicing factor CWC23
- J protein JJJ2
- Auxilin-like clathrin uncoating factor SWA2
- 60S ribosomal export protein NMD3
- ER-localized J domain-containing protein 5
- J domain-containing protein 1
- Glutathione-specific gamma-glutamylcyclotransferase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0048583 (regulation of response to stimulus), GO:0032879 (regulation of localization), GO:0050794 (regulation of cellular process), GO:2001023 (regulation of response to drug)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Multidrug transporter QDR2 (Clotrimazole exporter QDR2) (Drug:H(+) antiporter QDR2) (DHA QDR2) (Q6FSQ7)
Organism: Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus)
Function: Multidrug resistance transporter involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole, and ketoconazole; as well as to quinidine. Decreases the intracellular accumulation of clotrimazole in and plays a role in the extrusion of this antifungal from preloaded cells.
Subcellular location: Cell membrane {ECO:0000269|PubMed:23629708}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MMEDQQSLHSFISDYDQRSHAVEKYDGPDLSEVDSEDNDKMIKTNEDEAVKEPIYRTRSNQTEPDIANAPPYSRFDAKYKMALVLQCAYTGLFSTMAGAIYYPVLSVIEKQFHITEELVNITVVVYFIFQGIAPTLMGGLADSLGRRPVVLFAVTVYFGACIGLACAQTYAQIVVLRCLQAAGISPVIAINSGIIGDVTTRAERGGYVGYISGFQVLGSAFGALIGAGLSSRWGWRSIFWFLAIGSGVCLVFSIIMLPETKRTIVGNGSVTPRNYLNRAPLLMFPLIRRKLHLDDPEYETLEPRTQLSLLAPLSILKVKEISILLVTAGIQFATWSTHQTALSTVLSKNYHLSVAKIGLCYLPTGICTLISIVTSGRYLNWSYRRRFAKHKVWLKEQEEILVKENGYSREEVQNIINNDPKYVFNLVQTRLHAAFVTLLLSSSGFVAFGWCIDVKAPLASVLVMSGFASLFSNCILTFSTTLIVDIFPSKTSTATGCLNLFRCLLSALFIGCLSKMATSMTYGGVFTFLGALTALSACPLFYLLKNGREITLKRKRKEDASRAFALSVANEKAEAEGKAEESR
InterPro domains: - IPR011701: Major facilitator superfamily (family) [90-384]
- IPR036259: MFS transporter superfamily (homologous_superfamily) [63-557]
- IPR005829: Sugar transporter, conserved site (conserved_site) [137-153]
- IPR020846: Major facilitator superfamily domain (domain) [83-548]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0015562 (efflux transmembrane transporter activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0055085 (transmembrane transport), GO:0140352 (export from cell), GO:0140115 (export across plasma membrane), GO:1903825 (organic acid transmembrane transport), GO:0006810 (transport), GO:0071702 (organic substance transport), GO:0071705 (nitrogen compound transport), GO:1905039 (carboxylic acid transmembrane transport), GO:0015849 (organic acid transport), GO:0015711 (organic anion transport), GO:0046942 (carboxylic acid transport), GO:0015718 (monocarboxylic acid transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: Protocadherin alpha 1 (Q91Y21)
Organism: Mus musculus (Mouse)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
Sequence: MLFSRLRGLRARRLLLFSLLFLAAWEAGSGQIHYSVPEEAKHGTFVGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVEVKVKDINDNPPVFKGAEQRIFIPENRQLDSRFPLEGAVDADIGANSLLTYTLSPTDYFSLKVETTDELSKSLSLELRKSLDREETPELQLLLTATDGGKPELEGTVRLQITVLDVNDNAPLFDQAIYRAQLVESTVNGTLVTTLNATDADEGVNGEVVFSFGNDVSLDIQEKFNVDSLSGEIRVIGDLDYEKTKSYEIQIKAVDKGTPSMSNHCKVLVKVLDINDNAPELSITSLSLPIKEDTPLNTIIALIKVSDIDSGVNGQVTCSLTPHVPFKLVSTFKNYYSLVLDSTLDRETTADYKVVVTARDGGSPSLWATASVSVEVADVNDNAPVFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNPPTLLGPHAGSAVSELVSRTMGAGHVVTKVRAVDADSGYNAWLSYELQPPTGGARNPFRVGLYTGEISTTRSLDEVDVPRQRLLVLVKDHGEPMLTATATVLVSLVESSPIQKASLPVLTGAVGSKASLVDVNVYLIIAICAVSSLLVLTLLLYTALRCSATPTDGACGPGKPMLVCSSAVGSWSYSQQRRQKVCSGEGPPKTDLMAFSPGLAPGLNIAERSDHAEVNSDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
InterPro domains: - IPR050174: Protocadherin/Cadherin-related Cell Adhesion (family) [17-767]
- IPR002126: Cadherin-like (domain) [22-681]
- IPR031904: Cadherin, C-terminal catenin-binding domain (domain) [798-931]
- IPR013164: Cadherin, N-terminal (domain) [31-112]
- IPR015919: Cadherin-like superfamily (homologous_superfamily) [31-666]
- IPR020894: Cadherin conserved site (conserved_site) [231-564]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0005515 (protein binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0005509 (calcium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0007155 (cell adhesion), GO:0098609 (cell-cell adhesion), GO:0098742 (cell-cell adhesion via plasma-membrane adhesion molecules), GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane)
Protein: CKII alpha subunit interactor 1 (Q24161)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Sequence: MTEAEICKLCKDNLAIEIDLEKPKFKSANKLLQRLFDWYKIDAAILGENYCICEPCFGETLRISESLEKWGTAQDEFHRRPIEIDDSTAFQIKLEVTSNKEEVETEKNDEENSFDQHIAEPVKEDPLEKNEHMEIVVEESLKTASVDFFSVGLSRDGLAVTKFFKDKTQATRMLCTCCGHVLEILTHIRMHSCKPRPNPVYYCRDCGSEFHKLHELHEHMKTMKHNKTMCGAKDLEFLCLRCNQIFPRYFDVIRHENSVHNVSDFICVECNMSFANQGSYRRHTRSHKVKFTQQRFYECPYKDCTSSYRVWARLMSHMSSHGLFSGFKSKVPSTQQERRLLEGKFMTLDPMKRVEPDRRKLPYRKKSFYAKADFPESPTKCTNGGEFISLPKKISLQKGKYINLSDNSRP
InterPro domains: - IPR013087: Zinc finger C2H2-type (domain) [201-321]
- IPR036236: Zinc finger C2H2 superfamily (homologous_superfamily) [237-287]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0048584 (positive regulation of response to stimulus), GO:0009607 (response to biotic stimulus), GO:0002684 (positive regulation of immune system process), GO:0048583 (regulation of response to stimulus), GO:0002682 (regulation of immune system process), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0002831 (regulation of response to biotic stimulus), GO:0032103 (positive regulation of response to external stimulus), GO:0050776 (regulation of immune response), GO:0043207 (response to external biotic stimulus), GO:0002833 (positive regulation of response to biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0006952 (defense response), GO:0050778 (positive regulation of immune response), GO:0032101 (regulation of response to external stimulus), GO:0031349 (positive regulation of defense response), GO:0098542 (defense response to other organism), GO:0031347 (regulation of defense response), GO:0045089 (positive regulation of innate immune response), GO:0045088 (regulation of innate immune response), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Beta-toxin Ct13 (P0DUI0)
Organism: Centruroides tecomanus (Scorpion) (Centruroides limpidus tecomanus)
Function: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
Subcellular location: Secreted {ECO:0000269|PubMed:23840487}.
Sequence: MKVLILIIASVLLIGVECKDGFPVDSEGCILLPCATRAYCSVNCKFMKGSGGSCDTLACHCKGLPEDAKVQDKPTNKCGRK
InterPro domains: - IPR044062: LCN-type cysteine-stabilized alpha/beta (CS-alpha/beta) domain (domain) [19-79]
- IPR036574: Knottin, scorpion toxin-like superfamily (homologous_superfamily) [19-79]
- IPR002061: Scorpion long chain toxin/defensin (family) [19-67]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0090729 (toxin activity)
Biological Process (BP): GO:0008150 (biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0035821 (modulation of process of another organism)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Fibroblast growth factor-binding protein 1 (FGF-BP) (FGF-BP1) (FGF-binding protein 1) (FGFBP-1) (17 kDa heparin-binding growth factor-binding protein) (17 kDa HBGF-binding protein) (HBp17) (Q14512)
Organism: Homo sapiens (Human)
Function: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Cell membrane {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}; Peripheral membrane protein {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. {ECO:0000269|PubMed:11148217}.
Sequence: MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC
InterPro domains: - IPR010510: FGF binding 1 (family) [1-234]
Interaction partners: - Fibroblast growth factor 1
- Fibroblast growth factor 2
- Fibroblast growth factor 7
- Fibroblast growth factor 22
- Fibroblast growth factor 10
- Fibroblast growth factor 3
- Fibroblast growth factor 13
- Fibroblast growth factor 18
- Fibroblast growth factor 20
- Fibroblast growth factor 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0007154 (cell communication), GO:0007267 (cell-cell signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)
Protein: Insulin-like growth factor-binding protein 1 (M4Q8Z6)
Organism: Salmo salar (Atlantic salmon)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MLGLYKKLTLLAAMSLSLLTSLAQSSPVVGPEPIRCAPCTQEKLDECPAISPDCKQVLREPGCGCCLACALEKGASCGVYTAHCAQGLKCSPRPGDPRPLHSLTRGQAICTEDQGQEEVEGVPDHSSLTYFLGLNTPFDTKNEGAQESIKAKVNTIRKKLVEQGPCHIELHAALDKITSSQQELGEKFTNFYLPNCDKHGFYKAKQCESSLVGPPARCWCVFSWNGKKIPGSNYLLGGLECQLEL
InterPro domains: - IPR017891: Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site (conserved_site) [62-77]
- IPR036857: Thyroglobulin type-1 superfamily (homologous_superfamily) [154-243]
- IPR000867: Insulin-like growth factor-binding protein, IGFBP (domain) [32-113]
- IPR022321: Insulin-like growth factor-binding protein family 1-6, chordata (family) [74-221]
- IPR022322: Insulin-like growth factor-binding protein 1 (family) [47-237]
- IPR000716: Thyroglobulin type-1 (domain) [163-245]
- IPR009030: Growth factor receptor cysteine-rich domain superfamily (homologous_superfamily) [34-112]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019838 (growth factor binding), GO:0005520 (insulin-like growth factor binding), GO:0031994 (insulin-like growth factor I binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0009266 (response to temperature stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: At4g14020 (Rapid alkalinization factor (RALF) family protein) (O23263)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MEYYTFTENDEERVSRNHHVNNTWVKERYESDEEDGEVNKLILKEDEETKDMVTSPSGERMMLTSKVRYLTYGALKHDTAASAASGGGGRALPHPSNKYNRGHPKYYRCRG
InterPro domains: - IPR008801: Rapid ALkalinization Factor (family) [50-111]
Interaction partners: - Protein RALF-like 35
- Protein RALF-like 17
- Protein RALF-like 36
- UDP-URONIC ACID TRANSPORTER 1
- Transmembrane protein
- Transmembrane protein
- UDP-rhamnose/UDP-galactose transporter 2
- Rapid alkalinization factor 23
- Probable sugar phosphate/phosphate translocator At5g05820
- GPI-anchored protein LLG2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0050793 (regulation of developmental process), GO:0045926 (negative regulation of growth), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0040008 (regulation of growth), GO:0050794 (regulation of cellular process), GO:0045595 (regulation of cell differentiation), GO:0048638 (regulation of developmental growth), GO:2000026 (regulation of multicellular organismal development), GO:0051129 (negative regulation of cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0048640 (negative regulation of developmental growth), GO:0001558 (regulation of cell growth), GO:0030308 (negative regulation of cell growth), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051510 (regulation of unidimensional cell growth), GO:0022604 (regulation of cell morphogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Renalase (EC 1.6.3.5) (Q48MT7)
Organism: Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Function: Catalyzes the oxidation of the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. Has a preference for 1,2-dihydro-beta-NAD as substrate. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers.
Sequence: MTVPIAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGGRMSSKRSDAGSLDMGAQYFTARDRRFATAVKQWQAQGHVSEWTPLLYNFHGGRLSPSPDEQVRWVGEPGMSAITRAMRGDLPVSFSCRITDVFRGEQHWNLLDAEGENHGPFSHVIIATPAPQATALLAAAPKLASVVAGVKMDPTWAVALAFETPLQTPMQGCFVQDSPLDWLARNRSKPGRDDTLDSWVLHATSQWSRQNLDASREQVIEHLHGAFAELIDCAMPAPVFSLAHRWLYARPAGSHEWGALSDADLGIYVCGDWCLSGRVEGAWLSGQEAARRLLEHLQ
InterPro domains: - IPR002937: Amine oxidase (domain) [103-324]
- IPR036188: FAD/NAD(P)-binding domain superfamily (homologous_superfamily) [2-327]
- IPR034721: Bacterial renalase (family) [1-327]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016491 (oxidoreductase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0042440 (pigment metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0046148 (pigment biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0015995 (chlorophyll biosynthetic process), GO:1901362 (organic cyclic compound biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0033013 (tetrapyrrole metabolic process), GO:0019438 (aromatic compound biosynthetic process), GO:0018130 (heterocycle biosynthetic process), GO:0006778 (porphyrin-containing compound metabolic process), GO:0033014 (tetrapyrrole biosynthetic process), GO:0006779 (porphyrin-containing compound biosynthetic process), GO:0015994 (chlorophyll metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)