Protein: Amyloid-beta A4 protein (Q8UUR9)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|RuleBase:RU367156}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367156}. Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
Sequence: MGIDRTVFLLLMLTTLSLAIEVPSDDSVGLLAEPQVAMFCGKLNMHINVQSGKWEPDPTGTKSCISTKEGILKYCQEVYPDLQITNVVEANQPVSIQNWCKMGRRQCRSHTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDMCESHLHWHTVAKESCGDRSMNLHDYGMLLPCGIDRFRGVEFVCCPMEEQKDLDSEEQEEANSDVWWGGAETEYTDASVLKEQVTAKPDPAVTEDDEDLNNEEEEVWDNDEDGDGEDDEDEEDDDEDIIDEQDTSEQTSNIAMTTTTTTTTESIEEVVRVPTMAPSPADAVDRYLEAPGDMNEHMRFQKAKESLEAKHREKMSEVMREWEEAERQAKNLPRADKKTIIQRFQEKVESLEKEAAGERQQLVETHMARVEALLNDRRRQALESYLSSLQSDQPRPRQVLNLLKKYIRAEQKDRQHTLKHFEHVREVDPKKASQIRPFVMTHLRVIEERMNQSLGYLYKVPQVANDIQDQVAVLVQRDQAEVTQQLSSLQSKMRVSYGNDALMPDLPDSTTPLDNLPPEQDGLGFIHPESFNQANTDNHVEPVDARPIPERGLPTRPEIPKVRLDIEERHNAGYDVRDKRLMFLAEDMGSNKGAIIGLMVGGVVIATVIVITLVMLRKKQYTSIHHGVIEVDAAVTPEERHLAKMQQNGYENPTYKFFEQMQN
InterPro domains: - IPR011178: Amyloidogenic glycoprotein, copper-binding (domain) [134-190]
- IPR036176: E2 domain superfamily (homologous_superfamily) [303-519]
- IPR019745: Amyloidogenic glycoprotein, intracellular domain, conserved site (conserved_site) [680-687]
- IPR019744: Amyloidogenic glycoprotein, copper-binding domain conserved site (conserved_site) [183-190]
- IPR008154: Amyloidogenic glycoprotein, extracellular (domain) [26-191]
- IPR015849: Amyloidogenic glycoprotein, heparin-binding (domain) [33-133]
- IPR019543: Beta-amyloid precursor protein C-terminal (domain) [640-690]
- IPR008155: Amyloidogenic glycoprotein (family) [14-694]
- IPR013803: Amyloidogenic glycoprotein, amyloid-beta peptide (domain) [599-637]
- IPR024329: Amyloidogenic glycoprotein, E2 domain (domain) [308-505]
- IPR036454: Amyloidogenic glycoprotein, heparin-binding domain superfamily (homologous_superfamily) [19-125]
- IPR036669: Amyloidogenic glycoprotein, copper-binding domain superfamily (homologous_superfamily) [126-191]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [666-694]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0040007 (growth), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048589 (developmental growth), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0050793 (regulation of developmental process), GO:0016049 (cell growth), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0032989 (cellular component morphogenesis), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0060560 (developmental growth involved in morphogenesis), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009966 (regulation of signal transduction), GO:0000902 (cell morphogenesis), GO:0048588 (developmental cell growth), GO:0009888 (tissue development), GO:0010646 (regulation of cell communication), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0045664 (regulation of neuron differentiation), GO:0030030 (cell projection organization), GO:0008593 (regulation of Notch signaling pathway), GO:0001944 (vasculature development), GO:0032990 (cell part morphogenesis), GO:0002009 (morphogenesis of an epithelium), GO:0048666 (neuron development), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0072359 (circulatory system development), GO:0007417 (central nervous system development), GO:0060429 (epithelium development), GO:0048858 (cell projection morphogenesis), GO:1990138 (neuron projection extension), GO:0030182 (neuron differentiation), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0060026 (convergent extension), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0048675 (axon extension), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097546 (ciliary base), GO:0043227 (membrane-bounded organelle), GO:0120025 (plasma membrane bounded cell projection), GO:0005929 (cilium)