Protein: Histone-lysine N-methyltransferase NSD2 (B8JIA4)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Chromosome. Nucleus
Sequence: MTDSKGGSLPAMPEPKSPTSMKQLSDSPGGRNGLVDGITDPTMLMNKAATQLAATPQESVPQMIGSHGHNHTHEHLKDLTSRLLNGDTEKIPKLCAAPAGQPLLKGVEPVSQHASPPRKTSVSPELTVKITKCVVNLGGKPNRYEVDYTEEKAEETDAPLRLPEGVLTSPTARRDRQKKKGMVRKRIPPYPILTHAASSDQSPLLHPTINSNDITIEPCGLPVESIEHTHGDMPTCVTAFPDEQPLSDCEETVDAQGVDETDDAQGENDVKESYTETQSNVHFSVGDVIWTKVSGYPWWPCMITTDPEFNMHFRSKVNSRTGLLYHVQYFGDTPERGYVFEKCIVTFSGKHQYQSLSRSNQLPINISGRKRAVPRKFRQKWEIGVSQAKEALGLLTEERLAKFSFVYEDGKAQLNPHMLQVLEEQRNQGLQEEPVQREPQELVSLTPPDSTHSSPTNSSTTSTIPSLFSNPIDSSTSSGKTALPRKARKPSVKTNRRKQRSSTIEWIVTEASSAKQMPLTESTVQCEVNTEHKKKGKTNAGKRPYRKKDLLCIDLDLQPKASQKKPRHIRQKFPAAPNSVKKRKIKAGVSICDTLNTVSTSAGLSEVKASAPSTKLWEKEDASSKGMKKVCKRSRESKQDVTLQPKKKSKLEKDFKKWKCPKAASSAPAAVPAPRGRRRKTDRDENRKRSKKASKEEPPPKAKRGRKRKEESGRQSFPASKKCRPSSYAEPERPDSPSDSTDESHPSKKAERTPGAKKESVCLVCEQTGEDIVTCAGQCYGTYHLHCIGVERSAEKILCTACSTGVHVCFTCKKSEGEVRRCCALHCGRFYHEACVRLSALTVFENRGFRCPLHTCLSCHYSGRAACKATKGKMMRCLRCPVAYHVGDLCVAAGSEMISSSAIVCTNHFRAKKGYSHHSHVNVSWCFICSKGGRLLCCESCPAAFHPDCLNIAMPDGSWFCNDCRSGKKPKYRDVIWVKLGNYRWWPAEIRHPKNIPTNIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGSKYQQTGIGKVFKNALLDAETRFKEIEMEREAKEAHENNKKPPPFKYIKVNKPCGRVQVYTADISEIPKCNCKPSTERPCSFESECLNRMLLYECHPQVCPAGERCQNQDFTKRLYPETKIIRTAGKGWGLISLRDIKKGEFVNEYVGELIDEEECRSRIRHAQENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLGDRPKNGHTSEPKAKLQKKKPKRKRARNEGKKSEDECFRCGDGGQLVLCDKKGCTKAYHLSCLDRTKRPFGRWDCPWHHCDVCGKNSAAFCQLCPNSFCKAHQEGALRSHPLTGQLCCQEHEDSDIRPQTETAQLPPPTKPRKYRRRAEAKTTSKAPLKKRPRKNAEV
InterPro domains: - IPR050777: SET2 Histone-Lysine N-Methyltransferase (family) [686-1454]
- IPR047435: Nuclear SET domain-containing protein 2, second PWWP domain (domain) [971-1065]
- IPR011011: Zinc finger, FYVE/PHD-type (homologous_superfamily) [912-1372]
- IPR047437: Nuclear SET domain-containing protein 2, SET domain (domain) [1153-1294]
- IPR041306: NSD, Cys-His rich domain (domain) [1370-1416]
- IPR019786: Zinc finger, PHD-type, conserved site (conserved_site) [762-964]
- IPR055198: Histone-lysine N-methyltransferase NSD-like, PHD zinc finger (domain) [806-854]
- IPR046341: SET domain superfamily (homologous_superfamily) [1068-1294]
- IPR059153: Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 (domain) [756-802]
- IPR001965: Zinc finger, PHD-type (domain) [761-1372]
- IPR006560: AWS domain (domain) [1102-1153]
- IPR055197: Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger (domain) [856-908]
- IPR001214: SET domain (domain) [1154-1277]
- IPR003616: Post-SET domain (domain) [1278-1294]
- IPR013083: Zinc finger, RING/FYVE/PHD-type (homologous_superfamily) [746-1419]
- IPR019787: Zinc finger, PHD-finger (domain) [923-967]
- IPR000313: PWWP domain (domain) [283-1060]
Interaction partners: - Mitochondrial proton/calcium exchanger protein
- N-lysine methyltransferase SMYD2-A
- Ash1 (absent, small, or homeotic)-like (Drosophila)
- Negative elongation factor A
- Mediator of DNA damage checkpoint protein 1
- Lysine-specific demethylase 4B
- Histone H3.2
- Histone H3
- Histone H2B 3
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016741 (transferase activity, transferring one-carbon groups), GO:0008276 (protein methyltransferase activity), GO:0016279 (protein-lysine N-methyltransferase activity), GO:0008168 (methyltransferase activity), GO:0042054 (histone methyltransferase activity), GO:0018024 (histone lysine N-methyltransferase activity), GO:0140938 (histone H3 methyltransferase activity), GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity), GO:0008170 (N-methyltransferase activity), GO:0046975 (histone H3K36 methyltransferase activity), GO:0016278 (lysine N-methyltransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0044237 (cellular metabolic process), GO:0032259 (methylation), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0043414 (macromolecule methylation), GO:0009790 (embryo development), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0051216 (cartilage development), GO:0043412 (macromolecule modification), GO:0006479 (protein methylation), GO:0001501 (skeletal system development), GO:0061448 (connective tissue development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0008213 (protein alkylation), GO:0043009 (chordate embryonic development), GO:0018022 (peptidyl-lysine methylation), GO:0016571 (histone methylation), GO:0018193 (peptidyl-amino acid modification), GO:0016570 (histone modification), GO:0048706 (embryonic skeletal system development), GO:0034968 (histone lysine methylation), GO:0018027 (peptidyl-lysine dimethylation), GO:0018205 (peptidyl-lysine modification)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)