Protein: Neurobeachin a (E7EZD1)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Membrane {ECO:0000256|ARBA:ARBA00004370}.
Sequence: MSSERPVLAPGSASLTDREAPPAAAPPGSGQQVVTGSVTGDMMVSGSGAVVLPAGVINPSVPIRNIKMKFAVLIGLIQVGEVSNRDIVETVLNLLVGGEFDLEMNFIIQDAESIACMVELLEHCDVTCQAEIWSMFTAILRKSVRNLQTSTEVGLIQQVLQKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGDAGVWPRHAIKLLSVLNQMPQRHGPDTFFNFPGRSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGIGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQLVSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKSTFKFKSESDIHLAEHHKQVLYDGKLASSISFTYNAKATDAQLCLESSPRENASIFVHSPHALMLQDVKAIVTHSIHSAIHSIGGIQVLFPLFSQLDYRQPNDSPVETTVCATLLAFLVELLKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLTHGAPLLKQLCDHVLFNAAIWIHTPAKVQLSLYTYLSAEFIGTATIYSTIRRVGTVLQLMHTLKYYYWASNPLESSGITPKGLDGPRPSQKEIISLRAFMLLFLKQLILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLASKSESIRVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMMHTSTVTITTYNTLYEILTEQVCTQVVHKPHPEPDSTVKIQNPMILKVVATLLKSSSPSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNPEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGSVSTISGLSAQPTSVNGNLEIREIDDTSQTQTPESEVDYGENADSRILLAEAKVPESEAESSAAGVRVEVHDLLVDIKAEKVEATEVKLDDLDLSPEVLGGGGGMENGPLVEVDSLLDSAYCAAVHKLNGSLVPKEEESVVVGLTEDDGNMGPLITLADEKDSVPSNNGFLFPKVDEKLLPSLASTEPLVLPSPDQPPCSTTPHTSSASDDLSLLAHMTSCGSDLVQTPSGLEDDGFKLQSSLADISTLAEAEAQAAARTAECLEQESGDARAGKSSGDAASTTSDTERSDDGKDKEMKKIQTTATTQALHGRMSGQMERDLRVDLGFRGMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALESDVHMWRSHSTKSVMDFVNSNENIIFVHNTIHLISQMVDNIIIACGGILPLLSAATSPSSSKVSANPTQGSSCLQKGAKSSEVNSLPGSSGTGVETELENVEATQGMSSETAVTFLSRLMAMVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGSKTSLPISKTQENLQTAASASKTVIQNVPRNLSPIKDPDRLLQDVDINRLRAVVFRDVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQREIGRSSSLSGRSIRQEINSPTSTENPSLFSDGVRGERQAMTPLEDLPLEASLPHTDSGIGEEQVTGALNGSDLGTDHHSGLVGGSGGPDAMSELLCTLSSEVRKSSESLLESPLGVEVLKPAASISSISQANKGINVKEILKSLVAAPVEGAEAGPEPQPYHPDPALKREAAAMLPMQFHSFDRSVVVPVKKPPPGSLAVNTVGTPTSGAVPSSGSTPNIFAAATATPKSMINTTGATDSASSSSSSSSSFVNGATSKNLPAVQTVAPMPEDTVENMSAFCEVDQCPLRTRLTPPELKSFSSLTGFQTAPRDAGQFLSITTKLERALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTGLVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESNCAQYAADRREEEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGTMSQSQLHDFWRLDYWEDDLRRRRRFVRNAFGSTHTDVTLKSLEEYGPEEEEGMKSKKSFRSHSVVSQNPETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLVAPVIVARGTLSITTTEIYFEVDEDDPTFKKIDAKVLGYTEGLHGKWMFSEIRAVFSRRYLLQNTGLEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISLATPRQLFKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEDLDLTLPGNFRDLSKPIGALNPKRAVFYAERYETWEDDGAAPHHYSSLYSTAASTLYWLVRIEPFTTFFLNCNENKFDHPDRTFSGIARSWRSCQRDTSDVRELIPEFYYLPEMFVNSSGYDLGVREDRTAVCDVELPVWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLSYEGSINLDTITDPQLRESMEAQIQSFGQAPSQLLIEPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLSIPAAVTVTCSRLFAVNRWHNTVGLRGAPGYSLEQAHHLPIEMDSLIANNSGISKRQITDLVDQSIQINTHCFVVTADNRYILACGFWDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNNSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLRPRLISVSSEGHCIIYYERGQFCNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [488-967]
- IPR046851: Neurobeachin, beta-propeller domain (domain) [2715-2988]
- IPR010508: Neurobeachin-like, DUF1088 (domain) [2017-2184]
- IPR001680: WD40 repeat (repeat) [2721-2984]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [208-393]
- IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [2726-2995]
- IPR000409: BEACH domain (domain) [2326-2615]
- IPR036372: BEACH domain superfamily (homologous_superfamily) [2315-2615]
- IPR011989: Armadillo-like helical (homologous_superfamily) [667-916]
- IPR023362: PH-BEACH domain (domain) [2199-2307]
- IPR050865: BEACH Domain-Containing (family) [66-2987]
- IPR031570: Neurobeachin/BDCP, DUF4704 (domain) [464-943]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [2732-2985]
- IPR046852: Neurobeachin, alpha-solenoid region (domain) [83-217]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [2202-2306]
Interaction partners: - Gap junction protein
- Gap junction protein
- Tight junction protein 1b
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019900 (kinase binding), GO:0019901 (protein kinase binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0065008 (regulation of biological quality), GO:0051641 (cellular localization), GO:0071840 (cellular component organization or biogenesis), GO:0048871 (multicellular organismal-level homeostasis), GO:0032879 (regulation of localization), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:1902683 (regulation of receptor localization to synapse), GO:0098696 (regulation of neurotransmitter receptor localization to postsynaptic specialization membrane), GO:0060341 (regulation of cellular localization), GO:0048872 (homeostasis of number of cells), GO:0032880 (regulation of protein localization), GO:0008104 (protein localization), GO:0034330 (cell junction organization), GO:0061484 (hematopoietic stem cell homeostasis), GO:0050808 (synapse organization), GO:1904375 (regulation of protein localization to cell periphery), GO:1905475 (regulation of protein localization to membrane), GO:1902473 (regulation of protein localization to synapse)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0031984 (organelle subcompartment), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031090 (organelle membrane), GO:0005783 (endoplasmic reticulum), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0098827 (endoplasmic reticulum subcompartment), GO:0043231 (intracellular membrane-bounded organelle), GO:0005789 (endoplasmic reticulum membrane)