Protein: Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 3) (Triggering receptor expressed on myeloid cells-like protein 4) (Q3LRV9)
Organism: Mus musculus (Mouse)
Function: Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). Does not bind nucleic acids. May participate in antigen presentation.
Subcellular location: Cell membrane {ECO:0000305|PubMed:19155473, ECO:0000305|PubMed:22210914}; Single-pass type I membrane protein {ECO:0000305}.
Sequence: MAWRYSQLLLVPVQLVFLASVCCPGVWGSTVSEELHRMVGQSLSVQCQYKPKEESYVLKTWCRQTAPSKCTRVVTTSEPRKAARELQHTIWDDPEAGFFNITMTQLTEDDSAFYWCGPYYPSLREVTVLRNISLVVSPAPSTLPSQTIAPLPESTATIFMPFPVLTTSPEETTDSSINGTGHRNQSSSSPGWTSPGLLVSVQYGLLLLKALMLSVFCVLLCWRSGQGREYMAETMELSKLPHISKSLDTVSHISGYEKKANWY
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [31-117]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [32-143]
- IPR052314: Immune receptor domain-containing protein (family) [1-259]
- IPR007110: Immunoglobulin-like domain (domain) [24-116]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [28-137]
- IPR003599: Immunoglobulin domain subtype (domain) [32-137]
Interaction partners: - CMRF35-like molecule 2
- Trem-like transcript 1 protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009987 (cellular process), GO:0009605 (response to external stimulus), GO:0042221 (response to chemical), GO:0009607 (response to biotic stimulus), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0051707 (response to other organism), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0043207 (response to external biotic stimulus), GO:0010941 (regulation of cell death), GO:0070887 (cellular response to chemical stimulus), GO:0009617 (response to bacterium), GO:1901700 (response to oxygen-containing compound), GO:0071216 (cellular response to biotic stimulus), GO:0010033 (response to organic substance), GO:0071219 (cellular response to molecule of bacterial origin), GO:0032496 (response to lipopolysaccharide), GO:0071310 (cellular response to organic substance), GO:0043067 (regulation of programmed cell death), GO:0033993 (response to lipid), GO:0043068 (positive regulation of programmed cell death), GO:0002237 (response to molecule of bacterial origin), GO:1901701 (cellular response to oxygen-containing compound), GO:0071222 (cellular response to lipopolysaccharide), GO:0043065 (positive regulation of apoptotic process), GO:0042981 (regulation of apoptotic process), GO:0071396 (cellular response to lipid)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)