Protein: Collagen alpha-1(V) chain (O88207)
Organism: Mus musculus (Mouse)
Function: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter.
Subcellular location: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}.
Sequence: MDVHTRWKAARPGALLLSSPLLLFLLLLWAPPSSRAAQPADLLEMLDFHNLPSGVTKTTGFCATRRSSSEPDVAYRVSKDAQLSMPTKQLYPESGFPEDFSILTTVKAKKGSQAFLVSIYNEQGIQQLGLELGRSPVFLYEDHTGKPGPEEYPLFPGINLSDGKWHRIALSVYKKNVTLILDCKKKITKFLSRSDHPIIDTNGIVMFGSRILDDEIFEGDIQQLLFVSDNRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYPEGEGETYYYEYPYYEDPEDPGKEPAPTQKPVEAARETTEVPEEQTQPLPEAPTVPETSDTADKEDSLGIGDYDYVPPDDYYTPPPYEDFGYGEGVENPDQPTNPDSGAEVPTSTTVTSNTSNPAPGEGKDDLGGEFTEETIKNLEENYYDPYFDPDSDSSVSPSEIGPGMPANQDTIFEGIGGPRGEKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTTGPTGQMGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVSAQESQAQAILQQARLALRGPAGPMGLTGRPGPMGPPGSGGLKGEPGDMGPQGPRGVQGPPGPTGKPGRRGRAGSDGARGMPGQTGPKGDRGFDGLAGLPGEKGHRGDPGPSGPPGIPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPTGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGAAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGSEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGLPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGSRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGDPGLPGEGGPLGPKGERGEKGEAGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGDQGITGPSGPLGPPGPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGLPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGAGESYVDYADGMEEIFGSLNSLKLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGSTCVFPDKKSEGARITSWPKENPGSWFSEFKRGKLLSYVDAEGNPVGVVQMTFLRLLSASAHQNVTYNCYQSVAWQDAATGSYDKAIRFLGSNDEEMSYDNNPYIRALVDGCATKKGYQKTVLEIDTPKVEQVPIVDIMFNDFGEASQKFGFEVGPACFLG
InterPro domains: - IPR008160: Collagen triple helix repeat (repeat) [469-1571]
- IPR050149: Collagen superfamily (family) [975-1288]
- IPR001791: Laminin G domain (domain) [74-226]
- IPR013320: Concanavalin A-like lectin/glucanase domain superfamily (homologous_superfamily) [39-244]
- IPR000885: Fibrillar collagen, C-terminal (domain) [1608-1837]
- IPR048287: Thrombospondin-like, N-terminal domain (domain) [39-230]
Interaction partners: - Collagen alpha-2
- Collagen alpha-2
- Collagen alpha-1
- Collagen alpha-1
- Fibrillin-1
- Procollagen C-endopeptidase enhancer 1
- Lumican
- Serpin H1
- Collagen alpha-2
- A disintegrin and metalloproteinase with thrombospondin motifs 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005198 (structural molecule activity), GO:0005488 (binding), GO:1901681 (sulfur compound binding), GO:0005201 (extracellular matrix structural constituent), GO:0097367 (carbohydrate derivative binding), GO:0005515 (protein binding), GO:0008201 (heparin binding), GO:0030020 (extracellular matrix structural constituent conferring tensile strength), GO:0019838 (growth factor binding), GO:0005539 (glycosaminoglycan binding), GO:0043394 (proteoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0044237 (cellular metabolic process), GO:0098743 (cell aggregation), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0048729 (tissue morphogenesis), GO:0001502 (cartilage condensation), GO:1901564 (organonitrogen compound metabolic process), GO:0009888 (tissue development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0019538 (protein metabolic process), GO:0048513 (animal organ development), GO:0003206 (cardiac chamber morphogenesis), GO:0009790 (embryo development), GO:0016043 (cellular component organization), GO:0048839 (inner ear development), GO:0003205 (cardiac chamber development), GO:0044260 (cellular macromolecule metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901135 (carbohydrate derivative metabolic process), GO:0003208 (cardiac ventricle morphogenesis), GO:0051216 (cartilage development), GO:0048705 (skeletal system morphogenesis), GO:0048568 (embryonic organ development), GO:0042472 (inner ear morphogenesis), GO:0003007 (heart morphogenesis), GO:0001501 (skeletal system development), GO:0060415 (muscle tissue morphogenesis), GO:0043062 (extracellular structure organization), GO:0048562 (embryonic organ morphogenesis), GO:0009100 (glycoprotein metabolic process), GO:0061448 (connective tissue development), GO:0072359 (circulatory system development), GO:0002062 (chondrocyte differentiation), GO:0060537 (muscle tissue development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0048644 (muscle organ morphogenesis), GO:0003231 (cardiac ventricle development), GO:0045229 (external encapsulating structure organization), GO:0007517 (muscle organ development), GO:0097435 (supramolecular fiber organization), GO:0002063 (chondrocyte development), GO:0007507 (heart development), GO:0009792 (embryo development ending in birth or egg hatching), GO:0042471 (ear morphogenesis), GO:0043009 (chordate embryonic development), GO:0006029 (proteoglycan metabolic process), GO:0030198 (extracellular matrix organization), GO:0014706 (striated muscle tissue development), GO:0048704 (embryonic skeletal system morphogenesis), GO:0048738 (cardiac muscle tissue development), GO:0055008 (cardiac muscle tissue morphogenesis), GO:0043583 (ear development), GO:0048706 (embryonic skeletal system development), GO:0030199 (collagen fibril organization), GO:0055010 (ventricular cardiac muscle tissue morphogenesis), GO:0003229 (ventricular cardiac muscle tissue development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0005581 (collagen trimer), GO:0005615 (extracellular space), GO:0030312 (external encapsulating structure), GO:0005576 (extracellular region), GO:0031012 (extracellular matrix), GO:0062023 (collagen-containing extracellular matrix)