Protein: U2 small nuclear ribonucleoprotein A' (U2 snRNP A') (Looks exceptionally like U2A protein 1) (Q08963)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Involved in pre-mRNA splicing. Associates to U2 snRNA in a MSL1 dependent manner and is required for normal accumulation of U2 snRNA. Required for the spliceosome assembly and the efficient addition of U2 snRNP onto the pre-mRNA.
Subcellular location: Nucleus {ECO:0000269|PubMed:14562095}.
Sequence: MKFTPSIVIDAPQYYVDHFNGKYNVDKCVILRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDIHTLLLGRNNIVEVDGRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLETLDFQNVTAEERKSAMSFPRQADGDTLGPVNTAIRDNGSRDKTMEIMNLVVSKMTVERRNELKKQLAEATSLEEIARLEKLLSGGV
InterPro domains: - IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [19-170]
- IPR044640: U2 small nuclear ribonucleoprotein A' (family) [4-237]
- IPR001611: Leucine-rich repeat (repeat) [97-118]
- IPR003603: U2A'/phosphoprotein 32 family A, C-terminal (domain) [137-155]
Interaction partners: - Splicing factor MUD2
- Protein HSH49
- Pre-mRNA-splicing factor CWC2
- Pre-mRNA-splicing factor SNU114
- Protein LUC7
- Pre-mRNA-processing protein 45
- U1 small nuclear ribonucleoprotein A
- Pre-mRNA-splicing factor PRP46
- U1 small nuclear ribonucleoprotein 70 kDa homolog
- Pre-mRNA-splicing factor SNT309
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0017069 (snRNA binding), GO:0030620 (U2 snRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0044085 (cellular component biogenesis), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0016043 (cellular component organization), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0022613 (ribonucleoprotein complex biogenesis), GO:0043933 (protein-containing complex organization), GO:0010467 (gene expression), GO:0022607 (cellular component assembly), GO:0016070 (RNA metabolic process), GO:0022618 (ribonucleoprotein complex assembly), GO:0065003 (protein-containing complex assembly), GO:0006396 (RNA processing), GO:0071826 (ribonucleoprotein complex subunit organization), GO:0008380 (RNA splicing), GO:0000245 (spliceosomal complex assembly), GO:0006397 (mRNA processing), GO:0016071 (mRNA metabolic process), GO:0000398 (mRNA splicing, via spliceosome), GO:0000375 (RNA splicing, via transesterification reactions), GO:0000377 (RNA splicing, via transesterification reactions with bulged adenosine as nucleophile)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:1990904 (ribonucleoprotein complex), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0140513 (nuclear protein-containing complex), GO:0120114 (Sm-like protein family complex), GO:0005681 (spliceosomal complex), GO:0030532 (small nuclear ribonucleoprotein complex), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0097525 (spliceosomal snRNP complex), GO:0043231 (intracellular membrane-bounded organelle), GO:0071010 (prespliceosome), GO:0005684 (U2-type spliceosomal complex), GO:0071004 (U2-type prespliceosome), GO:0005686 (U2 snRNP), GO:0005634 (nucleus)