Protein: Small integral membrane protein 20 (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa) (MITRAC7) [Cleaved into: Phoenixin-14 (PNX-14); Phoenixin-20 (PNX-20)] (Q8N5G0)
Organism: Homo sapiens (Human)
Function: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover.
Subcellular location: [Small integral membrane protein 20]: Mitochondrion inner membrane {ECO:0000269|PubMed:26321642}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Phoenixin-14]: Secreted {ECO:0000250|UniProtKB:C0HLM6}.; SUBCELLULAR LOCATION: [Phoenixin-20]: Secreted {ECO:0000250|UniProtKB:C0HLM6}.
Sequence: MSRNLRTALIFGGFISLIGAAFYPIYFRPLMRLEEYKKEQAINRAGIVQEDVQPPGLKVWSDPFGRK
InterPro domains: - IPR027917: Small integral membrane protein 20 (family) [1-67]
Interaction partners: - Probable G-protein coupled receptor 173
- Cytochrome c oxidase assembly factor 3 homolog, mitochondrial
- Myosin light chain 1/3, skeletal muscle isoform
- Troponin I, cardiac muscle
- Troponin I, slow skeletal muscle
- Troponin I, fast skeletal muscle
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0044237 (cellular metabolic process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006091 (generation of precursor metabolites and energy), GO:0043933 (protein-containing complex organization), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0006996 (organelle organization), GO:0022900 (electron transport chain), GO:0061024 (membrane organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0007006 (mitochondrial membrane organization), GO:0045333 (cellular respiration), GO:0022904 (respiratory electron transport chain), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0019646 (aerobic electron transport chain), GO:0007007 (inner mitochondrial membrane organization), GO:0009060 (aerobic respiration), GO:0017004 (cytochrome complex assembly), GO:0042773 (ATP synthesis coupled electron transport), GO:0017062 (respiratory chain complex III assembly), GO:0006119 (oxidative phosphorylation), GO:0034551 (mitochondrial respiratory chain complex III assembly), GO:0042407 (cristae formation), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0006122 (mitochondrial electron transport, ubiquinol to cytochrome c)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)