Protein: Copine family protein 1 (Atypical copine family protein 1) (H2KYS8)
Organism: Caenorhabditis elegans
Function: Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin-mediated attachment sites.
Subcellular location: Basal cell membrane {ECO:0000269|PubMed:23283987}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:23283987}. Note=Colocalizes with unc-89, unc-112, pat-3 and pat-6 at the M-line and with alpha-actinin, unc-112, pat-3 and pat-6 in dense bodies. In body wall muscle cells, colocalizes with beta-integrin pat-3 at integrin adhesion sites. {ECO:0000269|PubMed:23283987}.
Sequence: MVFDARLGYDPDEWEECPEPEHFLVFSGFTRYMLTFAAIAFVYYFFKLLDDKNKKESGEKEEPQTSVESVLAKAGDKLHDVKEQVQQHIPESAEELMREADQYLKEQAHSVQNNVHQFAEQAANKFPSLEVDLNLGHPIDATREKFDTVLSSVNNHLHETKNMDLSPTSRDSTQFEQIPSIAPEESAFGHDFEHVPPHLKTAAEQYYAQQHQPPPVPQHKIVQPVPISPTDQQLLHEFDIYDAPAHQRMNQISEQLGQLGQKTPAQLQQLQHAQLAHQQLQQQGVFQPIQQPSPLQIQTHPQQPYFDFSQLSPASQARYNQQQFVDISQLSPGAGALIAEQQASGAFQPVTKKLGREKRLSEQDERALQDWEKEKALLEADRLKKLLDHEVGGDSTDLDSSQKAYDHFAPASHISYESHSGAAQIQPMTPTAPKRADVPAPQVTSITNVRDSQLTDYDISDFHAHDEPHYHTVLTPQQLQQNQQQHQQPSAIDRRRTTADSDDYVKVSEPIYDYPPKGHEAPVAEPKRISPTEAAQLQELYQEYDLGLDLPGVAPIQGVAKPPVQQRTPLQIQQQVVQNVQNQPNMMARQNSVPESPRTVINVPISRKTDVPIQVQQQQNQFSYNVPIQVKDDPRNLATADLFVQDAQEYVAHQQNQQDKGSFVMEEEMLSLHEPETGSNKKKLTPKNPSFEATSRQVRTNDVFERIEHDEHDDMTYAPEIQSVEIPPDQMSETSENMIDYFDKVAAESEQQIQHLQEQQNTLKKQQIETSIPDSSLLKPVGRAPQILPAFGNRISSNSSLGSAGRSGSGVSSSDVYPYRHLRKQSSLLSVLGVTSMQEMLLAITSLDSLSEAMRKAGLETTNLIFGIDYTASNKYQGEESFGGRSLHTIHPHVTNPYQQVISILGRTLAPFAGQGRLGVYGFGDAKTGDWSVFNLKGEGGDCRSLDEVLNVYNTVTPTVALSGPTNFAPLIYQAMEICQKSRDYHILVIIADGQVTNERATRRAIVQACQHPLSIIVVGVGDGPWDMMRIFDESLPKRPWDNFHFVEFHEIVKKSTNMEDGDVKLAVQSLLEIPDQYRCICELGLLDRSIPPRGSEIRREMMHNPL
InterPro domains: - IPR052079: E3 ubiquitin-ligases/Copine domain-containing protein (family) [581-1091]
- IPR002035: von Willebrand factor, type A (domain) [861-1051]
- IPR010734: Copine, C-terminal (domain) [886-1088]
- IPR036465: von Willebrand factor A-like domain superfamily (homologous_superfamily) [862-1031]
Interaction partners: - Protein espinas
- CTD small phosphatase-like protein 1
- Copine C-terminal domain-containing protein
- Protein maternal effect lethal 26
- Paralyzed arrest at two-fold protein 6
- CRE-UNC-96 protein
- Ig-like domain-containing protein
- LIM domain-containing protein unc-97
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding), GO:0019902 (phosphatase binding), GO:0019903 (protein phosphatase binding), GO:0008157 (protein phosphatase 1 binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0023052 (signaling), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0050793 (regulation of developmental process), GO:0051239 (regulation of multicellular organismal process), GO:0006950 (response to stress), GO:0042221 (response to chemical), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process), GO:0048580 (regulation of post-embryonic development), GO:2000026 (regulation of multicellular organismal development), GO:0030968 (endoplasmic reticulum unfolded protein response), GO:0010033 (response to organic substance), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0035966 (response to topologically incorrect protein), GO:0061062 (regulation of nematode larval development), GO:0035967 (cellular response to topologically incorrect protein), GO:0006986 (response to unfolded protein), GO:0071310 (cellular response to organic substance), GO:0045995 (regulation of embryonic development), GO:0034620 (cellular response to unfolded protein)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0042175 (nuclear outer membrane-endoplasmic reticulum membrane network), GO:0031967 (organelle envelope), GO:0005783 (endoplasmic reticulum), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)