Protein: Motilin receptor (G-protein coupled receptor 38) (O43193)
Organism: Homo sapiens (Human)
Function: Receptor for motilin.
Subcellular location: Cell membrane; Multi-pass membrane protein.
Sequence: MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
InterPro domains: - IPR017452: GPCR, rhodopsin-like, 7TM (domain) [55-355]
- IPR000276: G protein-coupled receptor, rhodopsin-like (family) [40-370]
- IPR003905: Growth hormone secretagogue receptor/motilin receptor (family) [32-159]
Interaction partners: - Promotilin
- Appetite-regulating hormone
- Neurotensin/neuromedin N
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0004888 (transmembrane signaling receptor activity), GO:0004930 (G protein-coupled receptor activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051234 (establishment of localization), GO:0051716 (cellular response to stimulus), GO:0065009 (regulation of molecular function), GO:0003008 (system process), GO:0048523 (negative regulation of cellular process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050790 (regulation of catalytic activity), GO:0044093 (positive regulation of molecular function), GO:0050878 (regulation of body fluid levels), GO:0042127 (regulation of cell population proliferation), GO:0007186 (G protein-coupled receptor signaling pathway), GO:0008285 (negative regulation of cell population proliferation), GO:0006810 (transport), GO:0008285 (negative regulation of cell population proliferation), GO:0003014 (renal system process), GO:0051339 (regulation of lyase activity), GO:0031279 (regulation of cyclase activity), GO:0035809 (regulation of urine volume), GO:0046903 (secretion), GO:0043085 (positive regulation of catalytic activity), GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway), GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway), GO:0045761 (regulation of adenylate cyclase activity), GO:0031281 (positive regulation of cyclase activity), GO:0051349 (positive regulation of lyase activity), GO:0035811 (negative regulation of urine volume), GO:0045762 (positive regulation of adenylate cyclase activity), GO:0007190 (activation of adenylate cyclase activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)