Protein: Histone H2A-like 1 (H2A.L.1) (H2AL1) (Histone H2Alike 1) (Q5M8Q2)
Organism: Mus musculus (Mouse)
Function: Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular location: Nucleus {ECO:0000269|PubMed:17261847}. Chromosome {ECO:0000269|PubMed:17261847}. Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). {ECO:0000269|PubMed:17261847}.
Sequence: MAKKMQRRRRQKRTRSQRGELPFSLVDRFLREEFHSSRLSSSALSFLTSVLEYLTSNILELAGEVAQTTGRKRIAPEDVRLVVQNNEQLRQLFKPGGTSVNEDDN
InterPro domains: - IPR009072: Histone-fold (homologous_superfamily) [1-102]
- IPR002119: Histone H2A (family) [2-104]
- IPR007125: Histone H2A/H2B/H3 (domain) [3-84]
Interaction partners: - Histone H2B type 1-A
- H2A histone family member L3
- Histone H1.9
- Huntingtin-interacting protein M
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042393 (histone binding)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0035092 (sperm DNA condensation), GO:0048515 (spermatid differentiation), GO:0007289 (spermatid nucleus differentiation), GO:0016043 (cellular component organization), GO:0007283 (spermatogenesis), GO:0006325 (chromatin organization), GO:0043933 (protein-containing complex organization), GO:0007286 (spermatid development), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0022607 (cellular component assembly), GO:0006338 (chromatin remodeling), GO:0006997 (nucleus organization), GO:0065003 (protein-containing complex assembly), GO:0071824 (protein-DNA complex subunit organization), GO:0006334 (nucleosome assembly), GO:0051276 (chromosome organization), GO:0034728 (nucleosome organization), GO:0065004 (protein-DNA complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0032993 (protein-DNA complex), GO:0098687 (chromosomal region), GO:0044815 (DNA packaging complex), GO:0000785 (chromatin), GO:0000786 (nucleosome), GO:0000792 (heterochromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0000775 (chromosome, centromeric region), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005721 (pericentric heterochromatin), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0005694 (chromosome), GO:0005634 (nucleus)