Protein: Aryl hydrocarbon receptor nuclear translocator homolog (dARNT) (Hypoxia-inducible factor 1-beta) (Protein tango) (O15945)
Organism: Drosophila melanogaster (Fruit fly)
Function: Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation.
Subcellular location: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
Sequence: MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDWQQAGGHPHPPHPTAHPHHPHAHPGGPAGAGQPQGQEFSDMLQMLDHTPTTFEDLNINMFSTPFE
InterPro domains: - IPR001067: Nuclear translocator (family) [28-301]
- IPR013767: PAS fold (domain) [90-192]
- IPR000014: PAS domain (domain) [85-380]
- IPR036638: Helix-loop-helix DNA-binding domain superfamily (homologous_superfamily) [3-98]
- IPR050933: Circadian Clock Transcription Factors (family) [4-618]
- IPR011598: Myc-type, basic helix-loop-helix (bHLH) domain (domain) [13-72]
- IPR035965: PAS domain superfamily (homologous_superfamily) [97-383]
Interaction partners: - Spineless, isoform C
- Protein similar
- Dysfusion, isoform D
- Protein single-minded
- Protein trachealess
- histone acetyltransferase
- hypoxia-inducible factor-proline dioxygenase
- Elongin-C
- Cullin-2
- POU domain protein CF1A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0140110 (transcription regulator activity), GO:0097159 (organic cyclic compound binding), GO:0003700 (DNA-binding transcription factor activity), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific), GO:0046983 (protein dimerization activity), GO:0003677 (DNA binding), GO:0046982 (protein heterodimerization activity)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009791 (post-embryonic development), GO:0050793 (regulation of developmental process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048522 (positive regulation of cellular process), GO:0048736 (appendage development), GO:0002165 (instar larval or pupal development), GO:0007552 (metamorphosis), GO:0048645 (animal organ formation), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0060255 (regulation of macromolecule metabolic process), GO:0035107 (appendage morphogenesis), GO:0009891 (positive regulation of biosynthetic process), GO:0045165 (cell fate commitment), GO:0001709 (cell fate determination), GO:0009887 (animal organ morphogenesis), GO:0003002 (regionalization), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0048859 (formation of anatomical boundary), GO:0009886 (post-embryonic animal morphogenesis), GO:0080090 (regulation of primary metabolic process), GO:0060581 (cell fate commitment involved in pattern specification), GO:0060582 (cell fate determination involved in pattern specification), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048880 (sensory system development), GO:0035120 (post-embryonic appendage morphogenesis), GO:0007423 (sensory organ development), GO:0048707 (instar larval or pupal morphogenesis), GO:0035114 (imaginal disc-derived appendage morphogenesis), GO:0010468 (regulation of gene expression), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048737 (imaginal disc-derived appendage development), GO:0031326 (regulation of cellular biosynthetic process), GO:0048569 (post-embryonic animal organ development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0048563 (post-embryonic animal organ morphogenesis), GO:0007560 (imaginal disc morphogenesis), GO:0051252 (regulation of RNA metabolic process), GO:0007444 (imaginal disc development), GO:0010160 (formation of animal organ boundary), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0007478 (leg disc morphogenesis), GO:0001654 (eye development), GO:0007480 (imaginal disc-derived leg morphogenesis), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:0150063 (visual system development), GO:0035220 (wing disc development), GO:0022416 (chaeta development), GO:0035218 (leg disc development), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0007476 (imaginal disc-derived wing morphogenesis), GO:0045893 (positive regulation of DNA-templated transcription), GO:0048749 (compound eye development), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005829 (cytosol), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0031981 (nuclear lumen), GO:0005634 (nucleus)