wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Nucleoporin (Q385W3)
Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Function: Not known
Sequence: MYQPLLEAPAGSPSAVVGDRLIGEAAGSLFGGSDRAAFEAQGGAYYPPWRPANANVISGGRYRAAGSGIMATWQRWPLYRLQTVLRPLTSLFPLLRVVFPFAVPGQDRCPQLCAAAFAERVTAISFHPVRMILAAAVNEGNDCSRVVVYDVAEGREECVLTHAFQRQTCCLAWKPLSRDVLAVGCNGGVLLWSLTFNMSPAGQAVLGNGNLTHRSVVNGTESSAPYCLFYRCAKNVVVTCIRFSCRDGRYLACGSAKHAALHFHDIRLQPSKSLLLRNVSVEGATQDVLFADDDSFAIRLVCGTSVLVLLQFPSCAANVVPTAAPVLGVTKARGLGPNYFFLHCHHVEGVFVAHINPFVGVHVIGLISTGIHRGVGGAVRCVASSDRRLFVALETGHLLVMHYGRRGVFTLIPVGTAEIGTECMAVFDGCTYGSLLAVVEADQSVSFVPAYHA
InterPro domains: - IPR015943: WD40/YVTN repeat-like-containing domain superfamily (homologous_superfamily) [109-310]
- IPR036322: WD40-repeat-containing domain superfamily (homologous_superfamily) [119-420]
- IPR045139: Aladin (family) [120-274]
Interaction partners: - Nuclear pore complex protein
- Nuclear pore protein
- Uncharacterized protein
- Nucleoporin
- Poly
- Nucleoporin
- Ran-binding protein 1, putative
- RanBD1 domain-containing protein
- Nucleoporin NSP1-like C-terminal domain-containing protein
- Protein transport protein sec13, putative
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0019222 (regulation of metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0010468 (regulation of gene expression), GO:0010608 (post-transcriptional regulation of gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0012505 (endomembrane system), GO:0031967 (organelle envelope), GO:0005635 (nuclear envelope), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: Arylsulfatase L (EC 3.1.6.1) (Arylsulfatase E) (ASE) (P51690)
Organism: Homo sapiens (Human)
Function: Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate. May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.
Subcellular location: Golgi apparatus, Golgi stack {ECO:0000269|PubMed:9497243}.
Sequence: MLHLHHSCLCFRSWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWCLREDDPQ
InterPro domains: - IPR017850: Alkaline-phosphatase-like, core domain superfamily (homologous_superfamily) [35-584]
- IPR050738: Sulfatase enzyme (family) [10-566]
- IPR024607: Sulfatase, conserved site (conserved_site) [84-147]
- IPR000917: Sulfatase, N-terminal (domain) [38-423]
Interaction partners: - Short stature homeobox protein
- 3-beta-hydroxysteroid-Delta
- Glycoprotein Xg
- Formylglycine-generating enzyme
- Anosmin-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0008484 (sulfuric ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0032502 (developmental process), GO:0048856 (anatomical structure development), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:0071704 (organic substance metabolic process), GO:1901575 (organic substance catabolic process), GO:0009888 (tissue development), GO:0006629 (lipid metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0008544 (epidermis development), GO:0016042 (lipid catabolic process), GO:0008202 (steroid metabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0006706 (steroid catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Chaperone protein YcdY (P75915)
Organism: Escherichia coli (strain K12)
Function: Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process.
Sequence: MNEFSILCRVLGSLYYRQPQDPLLVPLFTLIREGKLAANWPLEQDELLTRLQKSCDMTQVSADYNALFIGDECAVPPYRSAWVEGATEAEVRAFLSERGMPLADTPADHIGTLLLAASWLEDQSTEDESEALETLFSEYLLPWCGAFLGKVEAHATTPFWRTMAPLTRDAISAMWDELEEDSEE
InterPro domains: - IPR026269: Tat proofreading chaperone DmsD-type (family) [1-184]
- IPR050289: TorD/DmsD family chaperones (family) [2-181]
- IPR036411: TorD-like superfamily (homologous_superfamily) [2-180]
- IPR020945: DMSO/Nitrate reductase chaperone (family) [38-147]
Interaction partners: - Probable phosphatase YcdX
- Inner membrane protein YcdZ
- Glyoxylate/hydroxypyruvate reductase A
- Probable nitrate reductase molybdenum cofactor assembly chaperone NarW
- Chaperone protein TorD
- Hydrogenase-2 operon protein HybE
- Protein YhjJ
- Penicillin-binding protein activator LpoA
- Probable phospholipid transport protein YdbH
- Uncharacterized protein YhfK
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:0033218 (amide binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0042277 (peptide binding), GO:0042802 (identical protein binding), GO:0043546 (molybdopterin cofactor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0051604 (protein maturation), GO:0010467 (gene expression)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (P12656)
Organism: Mus musculus (Mouse)
Function: Indispensable for the control of thyroid structure and metabolism.
Subcellular location: Secreted.
Sequence: MSAAVLLSVLFALACGQAASFCIPTEYTMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPHHVTPYFSFPVAVSCKCGKCNTDNSDCIHEAVRTNYCTKPQSFYLGGFSV
InterPro domains: - IPR006208: Glycoprotein hormone subunit beta (domain) [20-125]
- IPR018245: Gonadotropin, beta subunit, conserved site (conserved_site) [47-125]
- IPR001545: Gonadotropin, beta subunit (family) [2-128]
- IPR029034: Cystine-knot cytokine (homologous_superfamily) [18-130]
Interaction partners: - Glycoprotein hormones alpha chain
- Thyrotropin receptor
- Follicle-stimulating hormone receptor
- Prolactin
- Lutropin-choriogonadotropic hormone receptor
- Pituitary-specific positive transcription factor 1
- Pro-thyrotropin-releasing hormone
- Prolactin-6A1
- Pro-opiomelanocortin
- Thyrotropin-releasing hormone receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0098772 (molecular function regulator activity), GO:0005488 (binding), GO:0030545 (signaling receptor regulator activity), GO:0140677 (molecular function activator activity), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0030546 (signaling receptor activator activity), GO:0048018 (receptor ligand activity), GO:0005179 (hormone activity)
Biological Process (BP): GO:0008150 (biological process), GO:0022414 (reproductive process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0019953 (sexual reproduction), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0022412 (cellular process involved in reproduction in multicellular organism), GO:0021700 (developmental maturation), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048609 (multicellular organismal reproductive process), GO:0007276 (gamete generation), GO:0007281 (germ cell development), GO:0071695 (anatomical structure maturation), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048469 (cell maturation), GO:0048515 (spermatid differentiation), GO:0009994 (oocyte differentiation), GO:0001556 (oocyte maturation), GO:0007283 (spermatogenesis), GO:0071695 (anatomical structure maturation), GO:0007292 (female gamete generation), GO:0048599 (oocyte development), GO:0048477 (oogenesis), GO:0007286 (spermatid development), GO:0048232 (male gamete generation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)
Protein: Battenin (A0A8I6ALZ9)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Endomembrane system {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004127}. Lysosome membrane {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein {ECO:0000256|RuleBase:RU361113}.
Sequence: MGSSESSWRRLEDSEREETDSEPQTPPLDNLSVLWKNAVGFWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLASISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQAGLSPQHTLLSMLGIPVLMLASYFLLLTSPEPLDPGGQDEAETAARQPLIGTETPESRPGTSWDLSLQERWTVFKGLLRYIIPLVLVYFAEYFINQGLFELLFFRNTSLSHAQQYRWYQMLYQAGVFASRSSLQCCRIRFTWILALLQCLNLAFLLADVCLTFLPSIYLIFIVILYEGLLGGAAYVNTFHNIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHLP
InterPro domains: - IPR036259: MFS transporter superfamily (homologous_superfamily) [20-408]
- IPR018460: Batten's disease protein Cln3, subgroup (family) [25-414]
- IPR003492: Batten's disease protein Cln3 (family) [33-414]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0005102 (signaling receptor binding), GO:0042975 (peroxisome proliferator activated receptor binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032501 (multicellular organismal process), GO:0042592 (homeostatic process), GO:0048871 (multicellular organismal-level homeostasis), GO:0051239 (regulation of multicellular organismal process), GO:0060249 (anatomical structure homeostasis), GO:0001894 (tissue homeostasis), GO:0044057 (regulation of system process), GO:0031644 (regulation of nervous system process), GO:0001895 (retina homeostasis), GO:0051931 (regulation of sensory perception), GO:0051930 (regulation of sensory perception of pain)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005768 (endosome), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0097708 (intracellular vesicle)
Protein: Rhodanese-like domain-containing protein 10 (Sulfurtransferase 10) (AtStr10) (Q9SR92)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Not known
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Sequence: MTVLLPQLNHIHKLPVVLNRRLRQSYRLPVISAVSGKELILSGKVRAVEPKEANAVVASEGYILLDVRPAWEREKARVKGSLHVPLFVEDPDNGPITLLKKWIHLGYIGLWTGQRFTMINDEFALRVVEAVPDKESKVLVVCGEGLRSLAAVSKLHGEGYKSLGWLTGGFNRVSEGDFPEIEGTEELRFATIGGVSFYLLKLLVLLPSFGQKSR
InterPro domains: - IPR044614: Rhodanese-like domain-containing protein 10 (family) [13-211]
- IPR001763: Rhodanese-like domain (domain) [48-182]
- IPR036873: Rhodanese-like domain superfamily (homologous_superfamily) [28-180]
Interaction partners: - 3-dehydroquinate synthase, chloroplastic
- Putative inactive
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016782 (transferase activity, transferring sulphur-containing groups), GO:0016783 (sulfurtransferase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0043412 (macromolecule modification), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0009451 (RNA modification), GO:0008380 (RNA splicing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0043227 (membrane-bounded organelle), GO:0009507 (chloroplast), GO:0042651 (thylakoid membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0031968 (organelle outer membrane), GO:0009579 (thylakoid), GO:0055035 (plastid thylakoid membrane), GO:0009535 (chloroplast thylakoid membrane), GO:0009534 (chloroplast thylakoid)
Protein: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (A0A2R8Y5K3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: XFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGSRAKPVVSDDDSEEEQEELRTCQITASLFPSNCNGSAHHWEMEDLAAQVFVDQD
InterPro domains: - IPR049730: SNF2/RAD5-like, C-terminal helicase domain (domain) [2-55]
- IPR018359: Bromodomain, conserved site (conserved_site) [331-388]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [1-123]
- IPR036427: Bromodomain-like superfamily (homologous_superfamily) [292-424]
- IPR001650: Helicase, C-terminal domain-like (domain) [1-96]
- IPR029295: Snf2, ATP coupling domain (domain) [171-239]
- IPR001487: Bromodomain (domain) [305-415]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0043170 (macromolecule metabolic process), GO:0046483 (heterocycle metabolic process), GO:0090304 (nucleic acid metabolic process), GO:0010467 (gene expression), GO:0016070 (RNA metabolic process), GO:0006396 (RNA processing), GO:0034470 (ncRNA processing), GO:0034660 (ncRNA metabolic process), GO:0016180 (snRNA processing), GO:0016073 (snRNA metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0001650 (fibrillar center), GO:0031974 (membrane-enclosed lumen), GO:0005654 (nucleoplasm), GO:0043233 (organelle lumen), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Large ribosomal subunit protein bL17m (39S ribosomal protein L17, mitochondrial) (L17mt) (MRP-L17) (LYST-interacting protein 2) (Q9NRX2)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
Sequence: MRLSVAAAISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRMLQIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQSQEASNHSSHTAQTPGI
InterPro domains: - IPR036373: Large ribosomal subunit protein bL17 superfamily (homologous_superfamily) [3-128]
- IPR000456: Large ribosomal subunit protein bL17 (family) [10-168]
Interaction partners: - Large ribosomal subunit protein bL36m
- Large ribosomal subunit protein bL33m
- Large ribosomal subunit protein bL21m
- Small ribosomal subunit protein uS9m
- Large ribosomal subunit protein uL23
- Large ribosomal subunit protein bL12m
- Small ribosomal subunit protein uS19
- Small ribosomal subunit protein bS6m
- Large ribosomal subunit protein uL5
- Elongation factor Tu, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007005 (mitochondrion organization), GO:0000002 (mitochondrial genome maintenance)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: Glutathione gamma-glutamylcysteinyltransferase (EC 2.3.2.15) (Phytochelatin synthase) (PC synthase) (A5JYS0)
Organism: Caenorhabditis elegans
Function: Involved in the synthesis of phytochelatins, which are heavy metal binding proteins required for the detoxification of heavy metals such as cadmium, arsenic and copper.
Sequence: MSQRRHFKMSVTAKNFYRRPLPETCIEFSSELGKKLFTEALVRGSANIYFKLASQFRTQDEPAYCGLSTLVMVLNALEVDPEKVWKAPWRFYHESMLDCCVPLENIRKSGINLQQFSCLAKCNRLKSTVSYGDNSPDFLKKFRTSLVNSVRSDDQVLVASYDRSVLGQTGSGHFSPLAAYHEDSDQVLIMDVARFKYPPHWVKLETLQKALCSVDVTTKLPRGLVELELKKGTRPLIMYGLKAYVNINDSDFATSVISWNQFLLCDPLEDDEEEFQLCCRKFGQCFAPHAMCCTQKTFDADQKNSCTECSTDQNEACKMICSEIRRTRFAEVFSSSAVAALLIAWPFEKGYSERSDRIGNLAEKYKNEFSAETMNEMNQLTTQIRTLISCSKPPVVININKPDATSNKCCKNKIGQSCACANDVNL
InterPro domains: - IPR007719: Phytochelatin synthase, N-terminal catalytic domain (domain) [11-232]
- IPR040409: Phytochelatin synthase (family) [13-368]
- IPR038765: Papain-like cysteine peptidase superfamily (homologous_superfamily) [21-227]
- IPR038156: Phytochelatin synthase, N-terminal domain superfamily (homologous_superfamily) [24-231]
Interaction partners: - Heavy metal tolerance factor 1
- Metallothionein-2
- Metallothionein-1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016746 (acyltransferase activity), GO:0043169 (cation binding), GO:0016755 (aminoacyltransferase activity), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0046870 (cadmium ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0051179 (localization), GO:0051234 (establishment of localization), GO:0051641 (cellular localization), GO:0044238 (primary metabolic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051649 (establishment of localization in cell), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0046907 (intracellular transport), GO:0006810 (transport), GO:0043170 (macromolecule metabolic process), GO:0036211 (protein modification process), GO:0043412 (macromolecule modification), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)