Protein: Retinal Mueller cells isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl ester 13-cis isomerohydrolase C) (EC 3.1.1.90) (All-trans-retinylester 11-cis isomerohydrolase C) (Lutein isomerase) (Meso-zeaxanthin isomerase) (EC 5.3.3.22) (Retinal pigment epithelium-specific 65 kDa protein homolog C) (RPE56c) (A9C3R8)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Catalyzes both 11-cis retinol and 13-cis retinol, 2 stereoisomeric forms of retinoic acid from all-trans-retinyl ester. Acts as an alternative isomerohydrolase in retinal Mueller cells by catalyzing formation of 11-cis retinol, to meet the high demand for the chromophore by cones. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity).
Subcellular location: Cytoplasm {ECO:0000269|PubMed:21676174}. Cell membrane {ECO:0000269|PubMed:21676174}; Lipid-anchor {ECO:0000269|PubMed:21676174}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. {ECO:0000250|UniProtKB:Q28175}.
Sequence: MVSRLEHPAGGYKKVFESCEELAEPIPAHVSGEIPAWLSGSLLRMGPGLFEVGDEPFYHLFDGQALLHKFDLKDGRVTYHRRFIRTDAYVRAMTEKRVVITEFGTTAYPDPCKNIFSRFFTYFQGIEVTDNCLVNIYPIGEDFYACTETNFITKVDPDTLETVKKVDLCNYLSVNGLTAHPHIEADGTVYNIGNCFGKNMSLAYNIVKIPPLQEDKSDQFEKSKILVQFPSSERFKPSYVHSFGITENHFVFVETPVKINLLKFLTSWSIRGSNYMDCFESNDKMGTWFHLAAKNPGKYIDHKFRTSAFNIFHHINCFEDQGFIVVDLCTWKGHEFVYNYLYLANLRQNWEEVKKAALRAPQPEVRRYVLPLDIHREEQGKNLVSLPYTTATAVMRSDGTVWLEPEVLFSGPRQAFEFPQINYSKFNGKDYTFAYGLGLNHFVPDRICKLNVKSKETWIWQEPDAYPSEPLFVQSPDAEDEDDGVLLSIVVKPGVSQRPAFLLILKATDLTEIARAEVDVLIPVTLHGIYKP
InterPro domains: - IPR004294: Carotenoid oxygenase (family) [17-532]
Interaction partners: - Retinol dehydrogenase 10-B
- Retinol dehydrogenase 5
- Lecithin retinol acyltransferase b, tandem duplicate 2.
- Patatin-like phospholipase domain-containing 4.
- Lecithin retinol acyltransferase a
- Lecithin retinol acyltransferase b, tandem duplicate 1.
- Retinol dehydrogenase 20
- Retinol dehydrogenase 10-A
- O-acyltransferase
- O-acyltransferase.
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016853 (isomerase activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0052689 (carboxylic ester hydrolase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0030902 (hindbrain development), GO:0009887 (animal organ morphogenesis), GO:0060322 (head development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0090596 (sensory organ morphogenesis), GO:0007420 (brain development), GO:0022008 (neurogenesis), GO:0007417 (central nervous system development), GO:0007399 (nervous system development), GO:0048880 (sensory system development), GO:0030182 (neuron differentiation), GO:0007423 (sensory organ development), GO:0046530 (photoreceptor cell differentiation), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0150063 (visual system development), GO:0048699 (generation of neurons), GO:0001754 (eye photoreceptor cell differentiation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)