Protein: eIF4G1 protein (B2RU06)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQGGFRSLQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [760-1570]
- IPR003307: W2 domain (domain) [1440-1606]
- IPR003890: MIF4G-like, type 3 (domain) [768-996]
- IPR003891: Initiation factor eIF-4 gamma, MA3 (domain) [1248-1370]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0031369 (translation initiation factor binding), GO:0008190 (eukaryotic initiation factor 4E binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0042592 (homeostatic process), GO:0048519 (negative regulation of biological process), GO:0009605 (response to external stimulus), GO:0006807 (nitrogen compound metabolic process), GO:0045927 (positive regulation of growth), GO:0048871 (multicellular organismal-level homeostasis), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0048523 (negative regulation of cellular process), GO:0009058 (biosynthetic process), GO:0019222 (regulation of metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0040008 (regulation of growth), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0010942 (positive regulation of cell death), GO:0090068 (positive regulation of cell cycle process), GO:0060548 (negative regulation of cell death), GO:0080134 (regulation of response to stress), GO:0060255 (regulation of macromolecule metabolic process), GO:0050803 (regulation of synapse structure or activity), GO:0051098 (regulation of binding), GO:0044089 (positive regulation of cellular component biogenesis), GO:0044087 (regulation of cellular component biogenesis), GO:0045787 (positive regulation of cell cycle), GO:0009894 (regulation of catabolic process), GO:0051726 (regulation of cell cycle), GO:0006413 (translational initiation), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0031668 (cellular response to extracellular stimulus), GO:0043603 (amide metabolic process), GO:0051128 (regulation of cellular component organization), GO:0044260 (cellular macromolecule metabolic process), GO:0010564 (regulation of cell cycle process), GO:0071496 (cellular response to external stimulus), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0044093 (positive regulation of molecular function), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0097009 (energy homeostasis), GO:0019538 (protein metabolic process), GO:0001558 (regulation of cell growth), GO:0080135 (regulation of cellular response to stress), GO:0044249 (cellular biosynthetic process), GO:0051130 (positive regulation of cellular component organization), GO:0034641 (cellular nitrogen compound metabolic process), GO:0030307 (positive regulation of cell growth), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0009991 (response to extracellular stimulus), GO:0010941 (regulation of cell death), GO:0031325 (positive regulation of cellular metabolic process), GO:0033554 (cellular response to stress), GO:0009889 (regulation of biosynthetic process), GO:0031323 (regulation of cellular metabolic process), GO:0009890 (negative regulation of biosynthetic process), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009059 (macromolecule biosynthetic process), GO:0043254 (regulation of protein-containing complex assembly), GO:0007346 (regulation of mitotic cell cycle), GO:0050807 (regulation of synapse organization), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0031330 (negative regulation of cellular catabolic process), GO:0043555 (regulation of translation in response to stress), GO:0010468 (regulation of gene expression), GO:1901566 (organonitrogen compound biosynthetic process), GO:0006412 (translation), GO:0010507 (negative regulation of autophagy), GO:0002183 (cytoplasmic translational initiation), GO:0031667 (response to nutrient levels), GO:0010563 (negative regulation of phosphorus metabolic process), GO:0031327 (negative regulation of cellular biosynthetic process), GO:0010467 (gene expression), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:1901215 (negative regulation of neuron death), GO:0010562 (positive regulation of phosphorus metabolic process), GO:0006518 (peptide metabolic process), GO:0034250 (positive regulation of amide metabolic process), GO:1901989 (positive regulation of cell cycle phase transition), GO:0006446 (regulation of translational initiation), GO:1901888 (regulation of cell junction assembly), GO:0051248 (negative regulation of protein metabolic process), GO:0010506 (regulation of autophagy), GO:0043604 (amide biosynthetic process), GO:1901214 (regulation of neuron death), GO:0010628 (positive regulation of gene expression), GO:0045931 (positive regulation of mitotic cell cycle), GO:0051099 (positive regulation of binding), GO:0034976 (response to endoplasmic reticulum stress), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0034248 (regulation of amide metabolic process), GO:1901987 (regulation of cell cycle phase transition), GO:0031326 (regulation of cellular biosynthetic process), GO:0051247 (positive regulation of protein metabolic process), GO:0010558 (negative regulation of macromolecule biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0034645 (cellular macromolecule biosynthetic process), GO:0031329 (regulation of cellular catabolic process), GO:0031669 (cellular response to nutrient levels), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0051174 (regulation of phosphorus metabolic process), GO:0031334 (positive regulation of protein-containing complex assembly), GO:0031400 (negative regulation of protein modification process), GO:0045937 (positive regulation of phosphate metabolic process), GO:0031047 (RNA-mediated gene silencing), GO:0002181 (cytoplasmic translation), GO:1902808 (positive regulation of cell cycle G1/S phase transition), GO:0051963 (regulation of synapse assembly), GO:1901992 (positive regulation of mitotic cell cycle phase transition), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0099174 (regulation of presynapse organization), GO:0031401 (positive regulation of protein modification process), GO:0060147 (regulation of post-transcriptional gene silencing), GO:0017148 (negative regulation of translation), GO:0043043 (peptide biosynthetic process), GO:0060966 (regulation of gene silencing by RNA), GO:0031399 (regulation of protein modification process), GO:0016441 (post-transcriptional gene silencing), GO:0019220 (regulation of phosphate metabolic process), GO:1901990 (regulation of mitotic cell cycle phase transition), GO:1902806 (regulation of cell cycle G1/S phase transition), GO:0006417 (regulation of translation), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:0045936 (negative regulation of phosphate metabolic process), GO:0045727 (positive regulation of translation), GO:0010608 (post-transcriptional regulation of gene expression), GO:0001932 (regulation of protein phosphorylation), GO:0042326 (negative regulation of phosphorylation), GO:1900368 (regulation of post-transcriptional gene silencing by RNA), GO:0042327 (positive regulation of phosphorylation), GO:1900087 (positive regulation of G1/S transition of mitotic cell cycle), GO:0001934 (positive regulation of protein phosphorylation), GO:0042325 (regulation of phosphorylation), GO:0001933 (negative regulation of protein phosphorylation), GO:0035194 (RNA-mediated post-transcriptional gene silencing), GO:2000045 (regulation of G1/S transition of mitotic cell cycle), GO:1905606 (regulation of presynapse assembly), GO:0033138 (positive regulation of peptidyl-serine phosphorylation), GO:0010799 (regulation of peptidyl-threonine phosphorylation), GO:0033135 (regulation of peptidyl-serine phosphorylation), GO:0010801 (negative regulation of peptidyl-threonine phosphorylation), GO:0060964 (regulation of miRNA-mediated gene silencing), GO:0035195 (miRNA-mediated gene silencing)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)