Protein: TGF-beta receptor type-1 (B0EXP6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular location: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Cell surface. Membrane raft
Sequence: MSSAAMDVASLTSRSLLLALLVLSVTHEAQGLLCYCERCVNRSCNTTGLCFAVIAKSSGQTVTQERQCIQQDDLYPRDRPFQCAPSNNGKHPYCCNTHMCNKNPKVIPELPEAEPQSMSPIALAAMIAVPICVLSFVLVLLFYMCHNRSIIHHRVPSEEDPTMDHPFLADGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMRHFESFKRADIYALGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEDMKRVVCDQKLRPNIPNRWQSCEALRVMAKIMRECWYANGGARLTALRVKKSLSQLSQQEGIKI
InterPro domains: - IPR045860: Snake toxin-like superfamily (homologous_superfamily) [29-107]
- IPR008271: Serine/threonine-protein kinase, active site (active_site) [326-338]
- IPR011009: Protein kinase-like domain superfamily (homologous_superfamily) [177-489]
- IPR017441: Protein kinase, ATP binding site (binding_site) [208-229]
- IPR003605: GS domain (domain) [172-202]
- IPR000472: Activin types I and II receptor domain (domain) [33-103]
- IPR000719: Protein kinase domain (domain) [202-492]
- IPR000333: Ser/Thr protein kinase, TGFB receptor (family) [19-495]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0048870 (cell motility), GO:0007389 (pattern specification process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0007154 (cell communication), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0048729 (tissue morphogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0035295 (tube development), GO:0009887 (animal organ morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0009790 (embryo development), GO:0007166 (cell surface receptor signaling pathway), GO:0016477 (cell migration), GO:0035239 (tube morphogenesis), GO:0009967 (positive regulation of signal transduction), GO:0048736 (appendage development), GO:0009799 (specification of symmetry), GO:0035107 (appendage morphogenesis), GO:0045165 (cell fate commitment), GO:0001704 (formation of primary germ layer), GO:0048598 (embryonic morphogenesis), GO:0042127 (regulation of cell population proliferation), GO:0009888 (tissue development), GO:0003002 (regionalization), GO:0010646 (regulation of cell communication), GO:0010647 (positive regulation of cell communication), GO:0060562 (epithelial tube morphogenesis), GO:0055123 (digestive system development), GO:0048732 (gland development), GO:0007369 (gastrulation), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0033333 (fin development), GO:0003143 (embryonic heart tube morphogenesis), GO:0030510 (regulation of BMP signaling pathway), GO:0002009 (morphogenesis of an epithelium), GO:0033334 (fin morphogenesis), GO:0048568 (embryonic organ development), GO:0003007 (heart morphogenesis), GO:0071772 (response to BMP), GO:0035050 (embryonic heart tube development), GO:0072359 (circulatory system development), GO:0009953 (dorsal/ventral pattern formation), GO:0007507 (heart development), GO:0072001 (renal system development), GO:0007501 (mesodermal cell fate specification), GO:0048333 (mesodermal cell differentiation), GO:0030097 (hemopoiesis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0048562 (embryonic organ morphogenesis), GO:0001707 (mesoderm formation), GO:1903224 (regulation of endodermal cell differentiation), GO:0033333 (fin development), GO:0060485 (mesenchyme development), GO:0060795 (cell fate commitment involved in formation of primary germ layer), GO:0048546 (digestive tract morphogenesis), GO:0061008 (hepaticobiliary system development), GO:0009855 (determination of bilateral symmetry), GO:0033334 (fin morphogenesis), GO:0060972 (left/right pattern formation), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0048332 (mesoderm morphogenesis), GO:0035113 (embryonic appendage morphogenesis), GO:0007498 (mesoderm development), GO:0060429 (epithelium development), GO:0001822 (kidney development), GO:0048565 (digestive tract development), GO:0071363 (cellular response to growth factor stimulus), GO:0009952 (anterior/posterior pattern specification), GO:0061371 (determination of heart left/right asymmetry), GO:0007368 (determination of left/right symmetry), GO:0048262 (determination of dorsal/ventral asymmetry), GO:0030903 (notochord development), GO:0035162 (embryonic hemopoiesis), GO:0001947 (heart looping), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0001889 (liver development), GO:0048793 (pronephros development), GO:0030513 (positive regulation of BMP signaling pathway), GO:0003146 (heart jogging), GO:0048264 (determination of ventral identity), GO:0001710 (mesodermal cell fate commitment), GO:0071773 (cellular response to BMP stimulus), GO:0003140 (determination of left/right asymmetry in lateral mesoderm), GO:0030509 (BMP signaling pathway)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:0005622 (intracellular anatomical structure), GO:0043235 (receptor complex), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098802 (plasma membrane signaling receptor complex), GO:0098797 (plasma membrane protein complex), GO:0005938 (cell cortex), GO:0005886 (plasma membrane)