Protein: Bcl-2-interacting killer (Apoptosis inducer NBK) (Bik-like killer protein) (O70337)
Organism: Mus musculus (Mouse)
Function: Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity.
Subcellular location: Endomembrane system {ECO:0000250|UniProtKB:Q13323}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:9525867}; Single-pass membrane protein {ECO:0000255}. Note=Around the nuclear envelope, and in cytoplasmic membranes. {ECO:0000250|UniProtKB:Q13323}.
Sequence: MSEARLMARDVIKTVPHDQVPQPPVASETPSMKEPVRDVDLMECVEGRNQVALRLACIGDEMDLCLRSPRLVQLPGIAIHRLAVTYSRTGVRGIFRSLIRSLTNLRENIWSWRVLTPGAWVSPDQDPGQLFPMVLLVFLLLGGAWYLQLQ
InterPro domains: - IPR024579: Bcl-2-interacting killer (family) [1-150]
Interaction partners: - Apoptosis regulator Bcl-2
- Bcl-2-like protein 1
- Bcl-2-like protein 2
- Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
- Phorbol-12-myristate-13-acetate-induced protein 1
- Bcl-2-like protein 11
- Activator of apoptosis harakiri
- Bcl-2-binding component 3
- Bcl-2-related protein A1
- Bcl-2 homologous antagonist/killer
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0008152 (metabolic process), GO:0022414 (reproductive process), GO:0042592 (homeostatic process), GO:0002376 (immune system process), GO:0048519 (negative regulation of biological process), GO:0019953 (sexual reproduction), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0009653 (anatomical structure morphogenesis), GO:0055085 (transmembrane transport), GO:0042221 (response to chemical), GO:0045321 (leukocyte activation), GO:0008283 (cell population proliferation), GO:0006807 (nitrogen compound metabolic process), GO:0071840 (cellular component organization or biogenesis), GO:0032504 (multicellular organism reproduction), GO:0003006 (developmental process involved in reproduction), GO:0048871 (multicellular organismal-level homeostasis), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0009791 (post-embryonic development), GO:0065008 (regulation of biological quality), GO:0008219 (cell death), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0007165 (signal transduction), GO:0048869 (cellular developmental process), GO:0009628 (response to abiotic stimulus), GO:0023056 (positive regulation of signaling), GO:0001775 (cell activation), GO:0007275 (multicellular organism development), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0033036 (macromolecule localization), GO:0048878 (chemical homeostasis), GO:0044237 (cellular metabolic process), GO:0008219 (cell death), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0006950 (response to stress), GO:0002262 (myeloid cell homeostasis), GO:0048609 (multicellular organismal reproductive process), GO:0007154 (cell communication), GO:0044238 (primary metabolic process), GO:0048522 (positive regulation of cellular process), GO:0001666 (response to hypoxia), GO:0012501 (programmed cell death), GO:0032388 (positive regulation of intracellular transport), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0009314 (response to radiation), GO:0098660 (inorganic ion transmembrane transport), GO:0048731 (system development), GO:0070482 (response to oxygen levels), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0060255 (regulation of macromolecule metabolic process), GO:0048608 (reproductive structure development), GO:0034220 (monoatomic ion transmembrane transport), GO:0046649 (lymphocyte activation), GO:0045184 (establishment of protein localization), GO:0070997 (neuron death), GO:0009894 (regulation of catabolic process), GO:0009887 (animal organ morphogenesis), GO:0046907 (intracellular transport), GO:0097190 (apoptotic signaling pathway), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0016043 (cellular component organization), GO:0007166 (cell surface receptor signaling pathway), GO:0009790 (embryo development), GO:0007548 (sex differentiation), GO:1901575 (organic substance catabolic process), GO:0044260 (cellular macromolecule metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0035239 (tube morphogenesis), GO:0046660 (female sex differentiation), GO:0007276 (gamete generation), GO:0050790 (regulation of catalytic activity), GO:0007281 (germ cell development), GO:1902742 (apoptotic process involved in development), GO:0051049 (regulation of transport), GO:1901564 (organonitrogen compound metabolic process), GO:0035556 (intracellular signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0001568 (blood vessel development), GO:0060341 (regulation of cellular localization), GO:0019538 (protein metabolic process), GO:0001974 (blood vessel remodeling), GO:0048515 (spermatid differentiation), GO:0051649 (establishment of localization in cell), GO:0098771 (inorganic ion homeostasis), GO:0060561 (apoptotic process involved in morphogenesis), GO:0010817 (regulation of hormone levels), GO:0031324 (negative regulation of cellular metabolic process), GO:0043170 (macromolecule metabolic process), GO:0007283 (spermatogenesis), GO:0048872 (homeostasis of number of cells), GO:0001525 (angiogenesis), GO:0030728 (ovulation), GO:0104004 (cellular response to environmental stimulus), GO:0010941 (regulation of cell death), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0006810 (transport), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0071705 (nitrogen compound transport), GO:0051246 (regulation of protein metabolic process), GO:0043067 (regulation of programmed cell death), GO:0048880 (sensory system development), GO:0001944 (vasculature development), GO:0030163 (protein catabolic process), GO:0071702 (organic substance transport), GO:0072331 (signal transduction by p53 class mediator), GO:1905897 (regulation of response to endoplasmic reticulum stress), GO:0009057 (macromolecule catabolic process), GO:0006886 (intracellular protein transport), GO:0051223 (regulation of protein transport), GO:0015031 (protein transport), GO:0072359 (circulatory system development), GO:0036293 (response to decreased oxygen levels), GO:0097193 (intrinsic apoptotic signaling pathway), GO:1902533 (positive regulation of intracellular signal transduction), GO:0043085 (positive regulation of catalytic activity), GO:0010212 (response to ionizing radiation), GO:0010629 (negative regulation of gene expression), GO:0032386 (regulation of intracellular transport), GO:0006839 (mitochondrial transport), GO:0071456 (cellular response to hypoxia), GO:0030097 (hemopoiesis), GO:0009416 (response to light stimulus), GO:1901565 (organonitrogen compound catabolic process), GO:0006508 (proteolysis), GO:0006974 (cellular response to DNA damage stimulus), GO:0071310 (cellular response to organic substance), GO:0051336 (regulation of hydrolase activity), GO:0043068 (positive regulation of programmed cell death), GO:0072594 (establishment of protein localization to organelle), GO:0007423 (sensory organ development), GO:0051248 (negative regulation of protein metabolic process), GO:0010506 (regulation of autophagy), GO:0006873 (intracellular monoatomic ion homeostasis), GO:2001233 (regulation of apoptotic signaling pathway), GO:0030099 (myeloid cell differentiation), GO:0055074 (calcium ion homeostasis), GO:0034976 (response to endoplasmic reticulum stress), GO:0098662 (inorganic cation transmembrane transport), GO:0055080 (monoatomic cation homeostasis), GO:0048514 (blood vessel morphogenesis), GO:0006915 (apoptotic process), GO:0051247 (positive regulation of protein metabolic process), GO:0042110 (T cell activation), GO:0097191 (extrinsic apoptotic signaling pathway), GO:0008104 (protein localization), GO:0006996 (organelle organization), GO:0048232 (male gamete generation), GO:0007005 (mitochondrion organization), GO:0042981 (regulation of apoptotic process), GO:0048592 (eye morphogenesis), GO:0030162 (regulation of proteolysis), GO:0052547 (regulation of peptidase activity), GO:0018193 (peptidyl-amino acid modification), GO:0150063 (visual system development), GO:0030003 (intracellular monoatomic cation homeostasis), GO:0007006 (mitochondrial membrane organization), GO:0009411 (response to UV), GO:0051345 (positive regulation of hydrolase activity), GO:0006874 (intracellular calcium ion homeostasis), GO:0043065 (positive regulation of apoptotic process), GO:0033365 (protein localization to organelle), GO:0001654 (eye development), GO:0046530 (photoreceptor cell differentiation), GO:0010332 (response to gamma radiation), GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway), GO:0071482 (cellular response to light stimulus), GO:0045862 (positive regulation of proteolysis), GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress), GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress), GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0031968 (organelle outer membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0098588 (bounding membrane of organelle), GO:0031966 (mitochondrial membrane), GO:0005741 (mitochondrial outer membrane)