Protein: Persulfide dioxygenase ETHE1 homolog, mitochondrial (EC 1.13.11.18) (Glyoxalase II) (Glx II) (Sulfur dioxygenase ETHE1) (Q9C8L4)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) gives rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. Required for normal endosperm development in seed, and thereby also required for normal embryo development.
Subcellular location: Mitochondrion {ECO:0000269|PubMed:22786886}.
Sequence: MVMTHFSRLRQLLLLQPKFLSSQPRPLRSPPPTFLRSVMGSSSSFSSSSSKLLFRQLFENESSTFTYLLADVSHPDKPALLIDPVDKTVDRDLKLIDELGLKLIYAMNTHVHADHVTGTGLLKTKLPGVKSVISKASGSKADLFLEPGDKVSIGDIYLEVRATPGHTAGCVTYVTGEGADQPQPRMAFTGDAVLIRGCGRTDFQEGSSDQLYESVHSQIFTLPKDTLIYPAHDYKGFEVSTVGEEMQHNPRLTKDKETFKTIMSNLNLSYPKMIDVAVPANMVCGLQDVPSQAN
InterPro domains: - IPR001279: Metallo-beta-lactamase (domain) [63-232]
- IPR044528: Persulfide dioxygenase-like, MBL-fold metallo-hydrolase domain (domain) [53-234]
- IPR036866: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like (homologous_superfamily) [53-281]
- IPR051682: Mitochondrial Persulfide Dioxygenase (family) [37-290]
Interaction partners: - Lactoylglutathione lyase
- Lactoylglutathione lyase GLX1
- Probable lactoylglutathione lyase, chloroplastic
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 2
- Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial
- Assimilatory sulfite reductase
- Sulfite oxidase
- 5'-adenylylsulfate reductase 3, chloroplastic
- 5'-adenylylsulfate reductase 2, chloroplastic
- 5'-adenylylsulfate reductase 1, chloroplastic
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0043167 (ion binding), GO:0016491 (oxidoreductase activity), GO:0043169 (cation binding), GO:0051213 (dioxygenase activity), GO:0016701 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen), GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005506 (iron ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0006749 (glutathione metabolic process), GO:0006790 (sulfur compound metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0009507 (chloroplast), GO:0043231 (intracellular membrane-bounded organelle)