Protein: Deoxycytidine kinase (dCK) (EC 2.7.1.74) (Deoxyadenosine kinase) (EC 2.7.1.76) (Deoxyguanosine kinase) (EC 2.7.1.113) (P48769)
Organism: Rattus norvegicus (Rat)
Function: Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine.
Subcellular location: Nucleus {ECO:0000250|UniProtKB:P27707}.
Sequence: MATPPKRFCSSPSTSSEGTRIKKISIEGNIAAGKSTFVNILKQVCEDWEVVPEPVARWCNVQSTQDEFEELTTSQKSGGNVLQMMYEKPERWSFIFQSYACLSRIRAQLASLNGSLRDAEKPVLFFERSVYSDRYIFASNLYESDCMNETEWTIYQDWHDWMNSQFGQSLELDGIIYLRATPEKCLNRIYIRGRDEEQGIPLEYLEKLHYKHESWLLHRTLKTNFEYLQEVPILTLDVNLDFKDKEESLVEKVKEFLSTT
InterPro domains: - IPR031314: Deoxynucleoside kinase domain (domain) [23-257]
- IPR002624: Deoxynucleoside kinase (family) [9-260]
- IPR050566: Deoxyribonucleoside Kinase (family) [14-257]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [20-260]
Interaction partners: - Cytidine deaminase
- Deoxycytidylate deaminase
- UMP-CMP kinase
- Cytosolic purine 5'-nucleotidase
- Adenosine kinase
- UMP-CMP kinase 2, mitochondrial
- Adenine phosphoribosyltransferase
- Adenylosuccinate lyase
- 3',5'-cyclic-AMP phosphodiesterase 4D
- Purine nucleoside phosphorylase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0016301 (kinase activity), GO:0019205 (nucleobase-containing compound kinase activity), GO:0019206 (nucleoside kinase activity), GO:0019136 (deoxynucleoside kinase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048856 (anatomical structure development), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0050794 (regulation of cellular process), GO:0048523 (negative regulation of cellular process), GO:0044238 (primary metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0051129 (negative regulation of cellular component organization), GO:1901576 (organic substance biosynthetic process), GO:0046483 (heterocycle metabolic process), GO:0019637 (organophosphate metabolic process), GO:0048513 (animal organ development), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0010033 (response to organic substance), GO:1901135 (carbohydrate derivative metabolic process), GO:0006793 (phosphorus metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0051128 (regulation of cellular component organization), GO:0006091 (generation of precursor metabolites and energy), GO:1901362 (organic cyclic compound biosynthetic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0031344 (regulation of cell projection organization), GO:0019438 (aromatic compound biosynthetic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0022900 (electron transport chain), GO:0034654 (nucleobase-containing compound biosynthetic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0019693 (ribose phosphate metabolic process), GO:0018130 (heterocycle biosynthetic process), GO:0090407 (organophosphate biosynthetic process), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:0031345 (negative regulation of cell projection organization), GO:1901137 (carbohydrate derivative biosynthetic process), GO:0015980 (energy derivation by oxidation of organic compounds), GO:0009141 (nucleoside triphosphate metabolic process), GO:0009117 (nucleotide metabolic process), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1901293 (nucleoside phosphate biosynthetic process), GO:0009259 (ribonucleotide metabolic process), GO:0045333 (cellular respiration), GO:0046390 (ribose phosphate biosynthetic process), GO:0010977 (negative regulation of neuron projection development), GO:0006163 (purine nucleotide metabolic process), GO:0072522 (purine-containing compound biosynthetic process), GO:0022904 (respiratory electron transport chain), GO:0009060 (aerobic respiration), GO:0009144 (purine nucleoside triphosphate metabolic process), GO:0009150 (purine ribonucleotide metabolic process), GO:0009260 (ribonucleotide biosynthetic process), GO:0009199 (ribonucleoside triphosphate metabolic process), GO:0042773 (ATP synthesis coupled electron transport), GO:0009165 (nucleotide biosynthetic process), GO:0006164 (purine nucleotide biosynthetic process), GO:0010975 (regulation of neuron projection development), GO:0009142 (nucleoside triphosphate biosynthetic process), GO:0009145 (purine nucleoside triphosphate biosynthetic process), GO:0006119 (oxidative phosphorylation), GO:0009201 (ribonucleoside triphosphate biosynthetic process), GO:0046034 (ATP metabolic process), GO:0009205 (purine ribonucleoside triphosphate metabolic process), GO:0042775 (mitochondrial ATP synthesis coupled electron transport), GO:0009152 (purine ribonucleotide biosynthetic process), GO:0006754 (ATP biosynthetic process), GO:0009206 (purine ribonucleoside triphosphate biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure)