Protein: Spi-1 proto-oncogene a (Transcription factor PU.1a) (F1QFB6)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|RuleBase:RU004019}.
Sequence: MLHYRMESCVISPLSEEIIPYEHEARPIYDFYPYLSTDPETHPESGCEYSSVYGHHSEFEPPPGSHFTELHTSTYRYGDMEAFHPGVDAAMGTILPVVPPQYTYISHPLYQRSPVPHCSTDEEEPGGRSPPFEVSEGEEDHDGHPSTSSTLSGNKRKVRLYQFLLDLLQDGDMRDCIWWVDRERGVFQFSSKHKETLASRWGQQKGNRKRMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGDVLRRVTMERRQYHH
InterPro domains: - IPR036390: Winged helix DNA-binding domain superfamily (homologous_superfamily) [147-254]
- IPR046328: ETS family (family) [107-241]
- IPR036388: Winged helix-like DNA-binding domain superfamily (homologous_superfamily) [132-257]
- IPR000418: Ets domain (domain) [157-245]
Interaction partners: - Interferon regulatory factor 8
- Macrophage colony-stimulating factor 1 receptor
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0003677 (DNA binding), GO:0043565 (sequence-specific DNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0001525 (angiogenesis), GO:0035295 (tube development), GO:0001568 (blood vessel development), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0080090 (regulation of primary metabolic process), GO:0035239 (tube morphogenesis), GO:0030097 (hemopoiesis), GO:0048514 (blood vessel morphogenesis), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0001944 (vasculature development), GO:0072359 (circulatory system development), GO:0001570 (vasculogenesis), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0030099 (myeloid cell differentiation), GO:0010468 (regulation of gene expression), GO:2001141 (regulation of RNA biosynthetic process), GO:0006355 (regulation of DNA-templated transcription), GO:1903506 (regulation of nucleic acid-templated transcription)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)