Protein: NADPH oxidase 3 (EC 1.6.3.-) (Q672K1)
Organism: Rattus norvegicus (Rat)
Function: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity (By similarity).
Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q672J9}; Multi-pass membrane protein {ECO:0000255}.
Sequence: MPTCWILNESVSFVVALLWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWARASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAHLFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVISLALILIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQEAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQEVVITKVVSHPSAVLELHMKKRDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSELCSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQSLPGLSKVYFYWICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTGWDEYQAIHIALHWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHPSSSIGVFFCGPKAMSKTLQKMCRLYSSSDPRGVHFYYNKENF
InterPro domains: - IPR017938: Riboflavin synthase-like beta-barrel (homologous_superfamily) [292-391]
- IPR017927: FAD-binding domain, ferredoxin reductase-type (domain) [285-395]
- IPR050369: Respiratory burst oxidase/Ferric reductase (family) [12-568]
- IPR013121: Ferric reductase, NAD binding domain (domain) [403-548]
- IPR000778: Cytochrome b245, heavy chain (family) [105-544]
- IPR039261: Ferredoxin-NADP reductase (FNR), nucleotide-binding domain (homologous_superfamily) [388-568]
- IPR013112: FAD-binding 8 (domain) [293-391]
- IPR013130: Ferric reductase transmembrane component-like domain (domain) [81-217]
Interaction partners: - Cytochrome b-245 light chain
- NADPH oxidase 2
- NADPH oxidase 1
- NADPH oxidase 4
- NADPH oxidase organizer 1
- Neutrophil cytosolic factor 1
- Dual oxidase 1
- NADPH oxidase activator 1
- Neutrophil cytosol factor 4
- Dual oxidase 2
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0044237 (cellular metabolic process), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0006950 (response to stress), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0042127 (regulation of cell population proliferation), GO:0072593 (reactive oxygen species metabolic process), GO:0031325 (positive regulation of cellular metabolic process), GO:0006979 (response to oxidative stress), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0008284 (positive regulation of cell population proliferation), GO:0048660 (regulation of smooth muscle cell proliferation), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:0006801 (superoxide metabolic process), GO:0048661 (positive regulation of smooth muscle cell proliferation), GO:2000379 (positive regulation of reactive oxygen species metabolic process), GO:0000302 (response to reactive oxygen species)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0032991 (protein-containing complex), GO:1902494 (catalytic complex), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0098796 (membrane protein complex), GO:0098797 (plasma membrane protein complex), GO:1990204 (oxidoreductase complex), GO:0005886 (plasma membrane)