Protein: Pentafunctional AROM polypeptide (Q5AME2)
Organism: Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Function: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis
Subcellular location: Cytoplasm
Sequence: MSIEKVPILGKETIHVGYGIADHIVREVIANLASSTYVIVTDTNMARTPQYSKLTDDFKTNLSEKRPESRLLTYCVSPGENNKNRATKAAVEDFLLQQGCTRDTVILAVGGGVIGDMIGFVAATFMRGVRVVQVPTTLLAMVDSSVGGKTAIDTPLGKNFIGAFHQPEYVFCDVSFLETLPARQFINGMAEVVKTAAIWNEEEFTRLENFSKKFLSVVTSKKPDLQSIKAELVKTVLESVRVKAGVVSSDEKEAGLRNLLNFGHTIGHAIEAVLTPEALHGECVSIGMIKEAELSRYLGILPPVAVARLSKCLVAYGLPVSIDDKEFLKKVGPKRHYVEIDILLKKMAIDKKNDGSKIRCVLLEKIGKCYQLKAHQVSKQDLSFVLTDEVLVHPFTNPPKENIIVPPGSKSISNRALILAALGNGTVRVKNLLHSDDTKHMLDAVASLKGAEISTEDNGETIVVKGNGGNLVTSGEELYLGNAGTASRFLTTVASLVGKSQASDDVILTGNARMQERPIGPLVDALGSNGSEIEYLNKQGSLPLKISAGNGLKGGRIELAATISSQYVSSILMCAPYAKEPVTLALVGGKPISQLYIDMTCAMMKSFGIEVTKSTTEEYTYHIPKGTYKNPSEYVIESDASSATYPLAFAAMTGTSCTIPNIGSSSLQGDAKFAVDVLKPMGCKVEQTTTSTTVTGPPRGHLKPLPHVDMEPMTDAFLTASVVAAVAKGGSSTSITGIANQRVKECNRIEAMVTELAKFGVPANELPDGIEIHGIDIEDLKTPEISKRGVSSYDDHRVAMSFSLLAGLCKEPVLILERSTTGKTWPGWWDILHSKFKIELDGYEPPFNTDKHVDKSSDKSIIVIGMRGTGKSTLSEWLASFLGFKMLDMDKYLEEKLGTGIKSLIKAKGWEYFRQEEAIVAKECFTKFSKGYVLSTGGGIVEGEDARQQLKSYADNGGIVLHLHRDLDETVTFLAADTTRPAYSSEVQEVWLRREKWYHECSNYHFYSSHCSTEDEFNHLRRSFVNYIKLITGAERPVVPAGRSAAVVLTSPDLNEVVGDLESITIGADAVELRVDLFKDTSAEFVAAQIAVIRKHADLPIIYTVRTVSQGGKFPDENVDELKSLLLLGIRLGVAYVDLQLTAPNELIEEISSKKGFTRVIGTYQDINGELKWNNVEWKNKYNQGVSMNADIVRLVGKANSIQDNLDLENFKKQNTLKPLIAFNLGSQGKLSQVLNGTFTPISHKLLPNDEEFLTIGELNQTYFDIGGFTAKKFWVIGSPIEHSRSPNLHNAGYKALNLPYQFGRFEATDVDVVYDNLINKPDFGGLAITMPLKLDIMKFATKLSDAAETIGAVNTLIPIEGGYFGDNTDWVGISNSFIRAGVPPKSSSNGLVVGAGGTSRAAIYALHQMGCAKIYLVNRTAAKLEELVKSFPKDYNLEIVETEQQADKASKVSLAVSCIPADKPLDGEVLKKIERILSNGSEQSAGFKPTLLEASYKPRVTPIMKLTEEQYKWKVIPGVEMLVNQGDRQFKLHTGFTAPYEIIHRAVVEE
InterPro domains: - IPR006264: 3-phosphoshikimate 1-carboxyvinyltransferase (family) [398-838]
- IPR013792: RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta (homologous_superfamily) [399-834]
- IPR010110: Shikimate dehydrogenase, AroM-type (domain) [1269-1548]
- IPR008289: Pentafunctional AroM protein (family) [1-1551]
- IPR001381: 3-dehydroquinate dehydratase type I (family) [1044-1263]
- IPR016037: 3-dehydroquinate synthase AroB (family) [13-381]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [1370-1549]
- IPR036968: Enolpyruvate transferase domain superfamily (homologous_superfamily) [405-829]
- IPR041121: SDH, C-terminal (domain) [1519-1548]
- IPR013708: Shikimate dehydrogenase substrate binding, N-terminal (domain) [1276-1357]
- IPR023193: 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site (conserved_site) [478-760]
- IPR000623: Shikimate kinase/Threonine synthase-like 1 (family) [858-1025]
- IPR056179: 3-dehydroquinate synthase, C-terminal domain (domain) [188-352]
- IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [848-1028]
- IPR031322: Shikimate kinase/gluconokinase (family) [867-1019]
- IPR013785: Aldolase-type TIM barrel (homologous_superfamily) [1029-1267]
- IPR046346: Aminoacid dehydrogenase-like, N-terminal domain superfamily (homologous_superfamily) [1267-1369]
- IPR030960: 3-dehydroquinate synthase, N-terminal domain (domain) [75-186]
- IPR006151: Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase (domain) [1388-1466]
- IPR001986: Enolpyruvate transferase domain (domain) [404-832]
Interaction partners: - Chorismate synthase
- Catabolic 3-dehydroquinase
- Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
- Phospho-2-dehydro-3-deoxyheptonate aldolase
- Multifunctional tryptophan biosynthesis protein
- Tryptophan synthase
- Chorismate mutase
- Anthranilate phosphoribosyltransferase
- prephenate dehydratase
- Histidine biosynthesis trifunctional protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0009058 (biosynthetic process), GO:0044237 (cellular metabolic process), GO:0071704 (organic substance metabolic process), GO:0044281 (small molecule metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0044249 (cellular biosynthetic process), GO:0006520 (amino acid metabolic process), GO:1901576 (organic substance biosynthetic process), GO:1901564 (organonitrogen compound metabolic process), GO:0044283 (small molecule biosynthetic process), GO:0006082 (organic acid metabolic process), GO:1901566 (organonitrogen compound biosynthetic process), GO:0008652 (amino acid biosynthetic process), GO:0016053 (organic acid biosynthetic process), GO:0043436 (oxoacid metabolic process), GO:1901605 (alpha-amino acid metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0046394 (carboxylic acid biosynthetic process), GO:1901607 (alpha-amino acid biosynthetic process), GO:0009066 (aspartate family amino acid metabolic process), GO:0009067 (aspartate family amino acid biosynthetic process), GO:0006553 (lysine metabolic process), GO:0009085 (lysine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005737 (cytoplasm), GO:0005622 (intracellular anatomical structure)