Protein: Protein TIC 62, chloroplastic (Translocon at the inner envelope membrane of chloroplasts 62) (AtTIC62) (Q8H0U5)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Involved in protein precursor import into chloroplasts. Part of the redox regulon consisting of TIC32, TIC 55 and TIC62. Acts as a membrane anchor of LFNR1 and LFNR2. Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids (By similarity).
Subcellular location: Plastid, chloroplast inner membrane {ECO:0000269|PubMed:20040542}; Peripheral membrane protein {ECO:0000269|PubMed:20040542}. Plastid, chloroplast stroma {ECO:0000269|PubMed:20040542}. Plastid, chloroplast thylakoid {ECO:0000269|PubMed:20040542}. Note=Shuttles between the membranes and the stroma, depending on the redox state of the plastidic NADP(+)/NADPH pool.
Sequence: MEGTCFLRGQPLTTIPSLPSRKGFLLQRWKTNRIVRFSGFKNHSVSGKSRSFDLSLRASGPIRASSVVTEASPTNLNSKEEDLVFVAGATGKVGSRTVRELLKLGFRVRAGVRSAQRAGSLVQSVKEMKLQNTDEGTQPVEKLEIVECDLEKKDSIQPALGNASVIICCIGASEKEISDITGPYRIDYLATKNLVDAATSAKVNNFILVTSLGTNKFGFPAAILNLFWGVLCWKRKAEEALIESGLNYAIVRPGGMERPTDAYKETHNLTLALDDTLFGGQVSNLQVAELLACMAKNPQLSFSKIVEVVAETTAPLTPIEKLLEKIPSKRPYVPPPKASVATKEVKPVPTKPVTQEPTAPKEDEAPPKEKNVKPRPLSPYASYEDLKPPTSPIPNSTTSVSPAKSKEVDATQVPVEANVVPVPDSTSNVPVVEVKQVEEKKERPLSPYARYENLKPPSSPSPTASSTRKSDSLSPGPTDSDTDKSSTVAKTVTETAVATSVTETSVATSVPETAVATSVTETAAPATSKMRPLSPYAIYADLKPPTSPTPASTGPKEAASVEDNSELPGGNNDVLKTVDGNLNTIPPSTPEAVPVVSSAIDTSLASGDNTAQPKPRPLSPYTMYADMKPPTSPLPSPVTNH
InterPro domains: - IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [83-310]
- IPR044719: Protein TIC 62-like (family) [1-637]
- IPR016040: NAD(P)-binding domain (domain) [88-298]
Interaction partners: - Ferredoxin--NADP reductase, leaf isozyme 1, chloroplastic
- Ferredoxin--NADP reductase, leaf isozyme 2, chloroplastic
- Short-chain dehydrogenase TIC 32, chloroplastic
- Protein TIC 55, chloroplastic
- Rhodanese-like domain-containing protein 4, chloroplastic
- Protein TIC 22, chloroplastic
- Protein TIC 40, chloroplastic
- Protein TIC110, chloroplastic
- NADH dehydrogenase flavoprotein 1, mitochondrial
- NADH dehydrogenase iron-sulfur protein 1, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0043167 (ion binding), GO:0043169 (cation binding), GO:0046872 (metal ion binding), GO:0046914 (transition metal ion binding), GO:0005507 (copper ion binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0042592 (homeostatic process), GO:0009987 (cellular process), GO:0048878 (chemical homeostasis), GO:0009628 (response to abiotic stimulus), GO:0019725 (cellular homeostasis), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0006950 (response to stress), GO:0055082 (intracellular chemical homeostasis), GO:0001666 (response to hypoxia), GO:0070887 (cellular response to chemical stimulus), GO:0033554 (cellular response to stress), GO:0070482 (response to oxygen levels), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0010033 (response to organic substance), GO:0071456 (cellular response to hypoxia), GO:0009743 (response to carbohydrate), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0071453 (cellular response to oxygen levels), GO:0036293 (response to decreased oxygen levels), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0051252 (regulation of RNA metabolic process), GO:0006996 (organelle organization), GO:0001678 (intracellular glucose homeostasis), GO:0010468 (regulation of gene expression), GO:0036294 (cellular response to decreased oxygen levels), GO:2001141 (regulation of RNA biosynthetic process), GO:0009657 (plastid organization), GO:0006355 (regulation of DNA-templated transcription), GO:0034284 (response to monosaccharide), GO:0009746 (response to hexose), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0071326 (cellular response to monosaccharide stimulus), GO:0071331 (cellular response to hexose stimulus), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0009532 (plastid stroma), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0016020 (membrane), GO:0005829 (cytosol), GO:0098796 (membrane protein complex), GO:0031975 (envelope), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0034357 (photosynthetic membrane), GO:0043229 (intracellular organelle), GO:0019867 (outer membrane), GO:0009536 (plastid), GO:0043228 (non-membrane-bounded organelle), GO:0043227 (membrane-bounded organelle), GO:0009521 (photosystem), GO:0009570 (chloroplast stroma), GO:0009507 (chloroplast), GO:0042651 (thylakoid membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031976 (plastid thylakoid), GO:0098588 (bounding membrane of organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0009526 (plastid envelope), GO:0042170 (plastid membrane), GO:0031968 (organelle outer membrane), GO:0009941 (chloroplast envelope), GO:0009579 (thylakoid), GO:0055035 (plastid thylakoid membrane), GO:0009535 (chloroplast thylakoid membrane), GO:0009534 (chloroplast thylakoid)