Protein: Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] (P53708)
Organism: Homo sapiens (Human)
Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Subcellular location: Membrane {ECO:0000269|PubMed:24439109}; Single-pass type I membrane protein {ECO:0000269|PubMed:24439109}. Cell membrane {ECO:0000269|PubMed:24439109}.
Sequence: MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTPEA
InterPro domains: - IPR048285: Integrin alpha, second immunoglobulin-like domain (domain) [641-781]
- IPR018184: Integrin alpha chain, C-terminal cytoplasmic region, conserved site (conserved_site) [1034-1049]
- IPR000413: Integrin alpha chain (family) [264-1041]
- IPR013649: Integrin alpha, first immunoglubulin-like domain (domain) [483-639]
- IPR028994: Integrin alpha, N-terminal (homologous_superfamily) [39-486]
- IPR013517: FG-GAP repeat (repeat) [268-422]
- IPR032695: Integrin domain superfamily (homologous_superfamily) [485-1015]
- IPR013519: Integrin alpha beta-propellor (repeat) [44-498]
- IPR048286: Integrin alpha, third immunoglobulin-like domain (domain) [787-1001]
Interaction partners: - Nephronectin
- Integrin beta-1
- Vitronectin
- Fibronectin
- Extracellular matrix organizing protein FRAS1
- FRAS1-related extracellular matrix protein 2
- FRAS1-related extracellular matrix protein 1
- Tenascin-X
- Tenascin-N
- Tenascin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0050840 (extracellular matrix binding), GO:0044877 (protein-containing complex binding), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0019955 (cytokine binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0050839 (cell adhesion molecule binding), GO:0005178 (integrin binding), GO:0019838 (growth factor binding), GO:0005102 (signaling receptor binding), GO:0015026 (coreceptor activity), GO:1901702 (salt transmembrane transporter activity), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0019899 (enzyme binding), GO:0001968 (fibronectin binding), GO:0019956 (chemokine binding), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0017134 (fibroblast growth factor binding), GO:0002020 (protease binding), GO:0005520 (insulin-like growth factor binding), GO:0005216 (monoatomic ion channel activity), GO:0022890 (inorganic cation transmembrane transporter activity), GO:0015085 (calcium ion transmembrane transporter activity), GO:0005262 (calcium channel activity), GO:0046873 (metal ion transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0031994 (insulin-like growth factor I binding), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0022843 (voltage-gated monoatomic cation channel activity), GO:0005244 (voltage-gated monoatomic ion channel activity), GO:0022832 (voltage-gated channel activity), GO:0005245 (voltage-gated calcium channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0023057 (negative regulation of signaling), GO:0009653 (anatomical structure morphogenesis), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0003008 (system process), GO:0033036 (macromolecule localization), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0090287 (regulation of cellular response to growth factor stimulus), GO:0009967 (positive regulation of signal transduction), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0070848 (response to growth factor), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0009891 (positive regulation of biosynthetic process), GO:0045184 (establishment of protein localization), GO:0035295 (tube development), GO:0000902 (cell morphogenesis), GO:0061061 (muscle structure development), GO:0009887 (animal organ morphogenesis), GO:0048598 (embryonic morphogenesis), GO:0009888 (tissue development), GO:0007611 (learning or memory), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0009889 (regulation of biosynthetic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0007166 (cell surface receptor signaling pathway), GO:0050877 (nervous system process), GO:0009790 (embryo development), GO:0080090 (regulation of primary metabolic process), GO:0048839 (inner ear development), GO:0072001 (renal system development), GO:0050890 (cognition), GO:0071559 (response to transforming growth factor beta), GO:0030030 (cell projection organization), GO:0042472 (inner ear morphogenesis), GO:0007167 (enzyme-linked receptor protein signaling pathway), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0048562 (embryonic organ morphogenesis), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0090092 (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0045229 (external encapsulating structure organization), GO:0010468 (regulation of gene expression), GO:0007613 (memory), GO:0010557 (positive regulation of macromolecule biosynthetic process), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0048568 (embryonic organ development), GO:0042692 (muscle cell differentiation), GO:0043062 (extracellular structure organization), GO:0090100 (positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0060537 (muscle tissue development), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:1903844 (regulation of cellular response to transforming growth factor beta stimulus), GO:0001822 (kidney development), GO:0031328 (positive regulation of cellular biosynthetic process), GO:0071363 (cellular response to growth factor stimulus), GO:0071560 (cellular response to transforming growth factor beta stimulus), GO:0051145 (smooth muscle cell differentiation), GO:2001141 (regulation of RNA biosynthetic process), GO:0043583 (ear development), GO:0001656 (metanephros development), GO:0006355 (regulation of DNA-templated transcription), GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway), GO:0042471 (ear morphogenesis), GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway), GO:0030198 (extracellular matrix organization), GO:0048745 (smooth muscle tissue development), GO:1902680 (positive regulation of RNA biosynthetic process), GO:0006357 (regulation of transcription by RNA polymerase II), GO:0045893 (positive regulation of DNA-templated transcription), GO:1903508 (positive regulation of nucleic acid-templated transcription), GO:0007179 (transforming growth factor beta receptor signaling pathway), GO:1903506 (regulation of nucleic acid-templated transcription), GO:0045944 (positive regulation of transcription by RNA polymerase II)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)