Protein: Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (Q9VKY2)
Organism: Drosophila melanogaster (Fruit fly)
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (Probable).
Sequence: MASHQYHQIANLLEKMTSTDKDFRFMATNDLMTELQKDSIILDDESEKKVVRMVLKLLEDKNGEVQNLAVKCLGPLVNKVKEIQVETIVDSLCANMMSNTEQLRDISSIGLKTVIAELPQSSNSLAPNVCQRITGKLSTAIEKEDVSVKLESLDILADLLSRFGEFLVPFHSTILKALMPQLASSRQAVRKRTIVALSFLLIQANSNAYNGVIDHLLDGLENPPNPAAIRTYIQCLASICRQAGHRLCNHIDRSMLLLSQYSQRDDDELREFCLQACEAFVMRCPDAINPHIPMILELCLNYITYDPNYNYETDDGDTGNAMDTEDDEYVDSEEYSDDDDMSWKVRRAAAKCLEVLISTRQELVEDFYRSLSPALIARFKEREENVKSDIFHAYVALLKNTRLTDDVANDHDSMDQVSGPTSLLIEQLPLIVKAIQPLMREKSMKTRQDCFLLLRELLNSLPGALGPYLDSIVPGISYSLNDKSSTSNMKIESLGFLYSLLQGHPPHVFHPHIPLLVPLVVTSVFDPFYKIATEALLVLQQLVKVIRPLEPNAAKSDFDAPSFVGQVYSCTLQKLKVTDVDQEVKERAIACMGQIIANMGDMLQNELAVCLPIFMERLKNEVTRLSSVKALTLIAASSLRIDLTPILHDVLPALGTFLRKNHRALKLHSLDLINKIVINYSSNFEANLLQTAIVEIPPLISDSDLHVAQYSLTLLSTVARRQPQALVGIHEQFLRSVLILVRSPLLQGSALNCTLELFQALVQTQLSGLDYHSLVSKLMAPVLGGNGDVKSRATAGAPSEVVQLHKQAYHSSAKCIAALTQQCPQVATPLATKLITDLQKRNDTEIIFCLLTIGEIGRHFDLSSIQVLPQTIIECFGATSEDVKAAASHALGAVSVGSLQTYLPLILHEIEVQPKRQYLLLHSLKEVISSLSVSPSGLAQLLPSVPSIWDQLFKHCECSEEGSRNVVAECLGKLVLVNPDELLPQLQQALRSESATMRTVVVSSVKFTISDQPQPIDVLLKQNIGEFLFALRDPEPQVRRVALVAFNSAVHNKPSLVRDLLPTLLPWLYSETKVKSELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLEQGLDRVDVMQFLDHVQAGLCDHYDIKMLTYLMTARLAILCPDKVLLRLDQFIQQLRDTCTHKVKANSVKQEYEKQDELKRSALRAVSALSQIPKANKNQQLVDFLKSIKETPELNKIFEYIQKDSITGSSDIIVMDQS
InterPro domains: - IPR016024: Armadillo-type fold (homologous_superfamily) [8-1224]
- IPR011989: Armadillo-like helical (homologous_superfamily) [1-1226]
- IPR013932: TATA-binding protein interacting (TIP20) (domain) [1056-1219]
- IPR039852: Cullin-associated NEDD8-dissociated protein 1/2 (family) [7-1233]
Interaction partners: - Cullin homolog 1
- Cullin-4A
- Cullin 3, isoform F
- Cullin-2
- RING-box protein 1A
- Cullin 6
- Ubiquitin-like protein NEDD8
- Cullin-5
- COP9 signalosome complex subunit 5
- Elongin-C
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0023056 (positive regulation of signaling), GO:0007275 (multicellular organism development), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0051234 (establishment of localization), GO:0023051 (regulation of signaling), GO:0033036 (macromolecule localization), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0048731 (system development), GO:0006810 (transport), GO:0048513 (animal organ development), GO:0009966 (regulation of signal transduction), GO:0070727 (cellular macromolecule localization), GO:0051649 (establishment of localization in cell), GO:0010647 (positive regulation of cell communication), GO:0045184 (establishment of protein localization), GO:0045880 (positive regulation of smoothened signaling pathway), GO:0006886 (intracellular protein transport), GO:0071705 (nitrogen compound transport), GO:0015031 (protein transport), GO:0072594 (establishment of protein localization to organelle), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0030111 (regulation of Wnt signaling pathway), GO:0008104 (protein localization), GO:0030177 (positive regulation of Wnt signaling pathway), GO:0008589 (regulation of smoothened signaling pathway), GO:0006606 (protein import into nucleus), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)