Protein: Syntaxin-5 (Q8K1E0)
Organism: Mus musculus (Mouse)
Function: Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.
Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q08851}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q08851}. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250|UniProtKB:Q08851}.
Sequence: MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAISSSSDSTPLPTPVALVPSPPDTMSCRDRTQEFQSACKSLQSRQNGIQTSKPALHAARQCSEFTLMARRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRNRREQFSRAPVSALPLAPNNLGGGPIILGAESRASRDVAIDMMDPRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA
InterPro domains: - IPR021538: Syntaxin-5, N-terminal, Sly1p-binding domain (domain) [53-74]
- IPR045242: Syntaxin (family) [90-350]
- IPR000727: Target SNARE coiled-coil homology domain (domain) [258-351]
- IPR006012: Syntaxin/epimorphin, conserved site (conserved_site) [269-309]
- IPR010989: SNARE (homologous_superfamily) [92-318]
Interaction partners: - Golgi SNAP receptor complex member 1
- Vesicle transport through interaction with t-SNAREs homolog 1A
- BET1 homolog
- Vesicle-trafficking protein SEC22b
- BET1-like protein
- Golgi SNAP receptor complex member 2
- Vesicle-associated membrane protein 4
- Synaptobrevin homolog YKT6
- Syntaxin-6
- Sec1 family domain-containing protein 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051641 (cellular localization), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009966 (regulation of signal transduction), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0051668 (localization within membrane), GO:0045184 (establishment of protein localization), GO:0009894 (regulation of catabolic process), GO:0046907 (intracellular transport), GO:0010646 (regulation of cell communication), GO:0031325 (positive regulation of cellular metabolic process), GO:0006810 (transport), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0010647 (positive regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0009896 (positive regulation of catabolic process), GO:0071705 (nitrogen compound transport), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0010256 (endomembrane system organization), GO:0098876 (vesicle-mediated transport to the plasma membrane), GO:0010506 (regulation of autophagy), GO:0071702 (organic substance transport), GO:0090150 (establishment of protein localization to membrane), GO:0006886 (intracellular protein transport), GO:0072657 (protein localization to membrane), GO:0015031 (protein transport), GO:0051247 (positive regulation of protein metabolic process), GO:0045732 (positive regulation of protein catabolic process), GO:0031331 (positive regulation of cellular catabolic process), GO:0016192 (vesicle-mediated transport), GO:0008104 (protein localization), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0061024 (membrane organization), GO:0033365 (protein localization to organelle), GO:0030162 (regulation of proteolysis), GO:0016241 (regulation of macroautophagy), GO:0016050 (vesicle organization), GO:1990778 (protein localization to cell periphery), GO:0043001 (Golgi to plasma membrane protein transport), GO:0061951 (establishment of protein localization to plasma membrane), GO:0048193 (Golgi vesicle transport), GO:0045862 (positive regulation of proteolysis), GO:1901800 (positive regulation of proteasomal protein catabolic process), GO:0006906 (vesicle fusion), GO:0072659 (protein localization to plasma membrane), GO:2000060 (positive regulation of ubiquitin-dependent protein catabolic process), GO:0061136 (regulation of proteasomal protein catabolic process), GO:0048284 (organelle fusion), GO:0061025 (membrane fusion), GO:2000058 (regulation of ubiquitin-dependent protein catabolic process), GO:0061025 (membrane fusion), GO:0006892 (post-Golgi vesicle-mediated transport), GO:0090174 (organelle membrane fusion), GO:1903050 (regulation of proteolysis involved in protein catabolic process), GO:0070972 (protein localization to endoplasmic reticulum), GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0005794 (Golgi apparatus), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)