Protein: NAD-dependent protein deacetylase (EC 2.3.1.286) (B2RZ31)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSFVSATCTVCRRSFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPRRKDVVQLGDVVQGVERLVDLLGWTQELQDLIQRENGKLDGQDG
InterPro domains: - IPR050134: NAD-dependent sirtuin protein deacylases (family) [1-244]
- IPR029035: DHS-like NAD/FAD-binding domain superfamily (homologous_superfamily) [1-252]
- IPR003000: Sirtuin family (family) [3-184]
- IPR017328: Sirtuin, class I (family) [1-256]
- IPR026591: Sirtuin, catalytic core small domain superfamily (homologous_superfamily) [9-157]
- IPR026590: Sirtuin family, catalytic core domain (domain) [1-238]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0019899 (enzyme binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0048519 (negative regulation of biological process), GO:0023056 (positive regulation of signaling), GO:0023057 (negative regulation of signaling), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0051050 (positive regulation of transport), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0007568 (aging), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0048522 (positive regulation of cellular process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1903530 (regulation of secretion by cell), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051047 (positive regulation of secretion), GO:0046887 (positive regulation of hormone secretion), GO:0060341 (regulation of cellular localization), GO:0009966 (regulation of signal transduction), GO:0010817 (regulation of hormone levels), GO:0031324 (negative regulation of cellular metabolic process), GO:0046883 (regulation of hormone secretion), GO:0010646 (regulation of cell communication), GO:0031323 (regulation of cellular metabolic process), GO:0010647 (positive regulation of cell communication), GO:0051222 (positive regulation of protein transport), GO:1903532 (positive regulation of secretion by cell), GO:2000377 (regulation of reactive oxygen species metabolic process), GO:1904951 (positive regulation of establishment of protein localization), GO:2000378 (negative regulation of reactive oxygen species metabolic process), GO:0070201 (regulation of establishment of protein localization), GO:0002793 (positive regulation of peptide secretion), GO:0032880 (regulation of protein localization), GO:1902532 (negative regulation of intracellular signal transduction), GO:0050714 (positive regulation of protein secretion), GO:0051223 (regulation of protein transport), GO:0090276 (regulation of peptide hormone secretion), GO:0090087 (regulation of peptide transport), GO:0051046 (regulation of secretion), GO:0090277 (positive regulation of peptide hormone secretion), GO:0050708 (regulation of protein secretion), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0032024 (positive regulation of insulin secretion), GO:0050796 (regulation of insulin secretion), GO:0002791 (regulation of peptide secretion), GO:0043409 (negative regulation of MAPK cascade), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0070372 (regulation of ERK1 and ERK2 cascade)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)