Protein: 3',5'-cyclic-nucleotide phosphodiesterase (PDEase) (EC 3.1.4.17) (P36599)
Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Function: Not known
Sequence: MHAALEIKEAEFQTDQVVGLVENSFTLYSLGQNGGPLESCCSSHLISDGAFQEIISLDGGSHLSALVELIQSKHLSVDSWSSITKYDNYTVENESYAKAWHLSEQRIKTFLITHCHLDHIYGAVINSAMFGPQNPRTIVGLNYVIDTLKKHVFNNLLWPSLDKAGFINFQVVEPSMYTSLTTTLSILPFPVNHGSSFGQELKSSAFLFRNNLSDRYFLAFGDVEPDMVASEPLNIHIWRACSSLIAQRKLSHILIECSTPDIPDTLLFGHFCPRHLVNELCILQSLVQSYGVIMPTLTCLLTHLKSHPLQSANPADVILEQLESLSSKSSLSVTFKILQRGQFYKF
InterPro domains: - IPR000396: Cyclic-AMP phosphodiesterase, class-II (family) [1-346]
- IPR024225: Cyclic-AMP phosphodiesterase class-II, conserved site (conserved_site) [114-128]
- IPR036866: Ribonuclease Z/Hydroxyacylglutathione hydrolase-like (homologous_superfamily) [31-323]
Interaction partners: - Adenylate cyclase
- Adenine phosphoribosyltransferase
- cAMP-dependent protein kinase regulatory subunit
- Adenosine kinase
- GMP synthase
- Guanylate kinase
- Adenylosuccinate lyase
- Inosine triphosphate pyrophosphatase
- AMP deaminase
- Adenylate kinase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0042578 (phosphoric ester hydrolase activity), GO:0008081 (phosphoric diester hydrolase activity), GO:0004112 (cyclic-nucleotide phosphodiesterase activity), GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity), GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity), GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0009056 (catabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0044248 (cellular catabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:1901575 (organic substance catabolic process), GO:0006793 (phosphorus metabolic process), GO:0034655 (nucleobase-containing compound catabolic process), GO:0044270 (cellular nitrogen compound catabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0019439 (aromatic compound catabolic process), GO:1901361 (organic cyclic compound catabolic process), GO:0046700 (heterocycle catabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0046434 (organophosphate catabolic process), GO:1901292 (nucleoside phosphate catabolic process), GO:0009117 (nucleotide metabolic process), GO:0009166 (nucleotide catabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)