Protein: Glycine receptor subunit alphaZ1 (O93430)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity)
Subcellular location: Postsynaptic cell membrane; Multi-pass membrane protein. Synapse. Perikaryon. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein
Sequence: MFALGIYLWETIVFFSLAASQQAAARKAASPMPPSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFIARQHKELLRFQRRRRHLKEDEAGDGRFSFAAYGMGPACLQAKDGMAIKGNNNNAPTSTNPPEKTVEEMRKLFISRAKRIDTVSRVAFPLVFLIFNIFYWITYKIIRSEDIHKQ
InterPro domains: - IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [37-244]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [162-176]
- IPR008128: Glycine receptor alpha1 (family) [4-389]
- IPR006028: Gamma-aminobutyric acid A receptor/Glycine receptor alpha (family) [247-433]
- IPR006201: Neurotransmitter-gated ion-channel (family) [7-433]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [251-346]
- IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [242-444]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [26-243]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [244-440]
- IPR008127: Glycine receptor alpha (family) [31-339]
Interaction partners: - Gephyrin
- Gephyrin
- Transporter
- Glycine receptor subunit beta
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0036094 (small molecule binding), GO:0022857 (transmembrane transporter activity), GO:0043167 (ion binding), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0043168 (anion binding), GO:0043169 (cation binding), GO:0022803 (passive transmembrane transporter activity), GO:1901702 (salt transmembrane transporter activity), GO:0043177 (organic acid binding), GO:0015318 (inorganic molecular entity transmembrane transporter activity), GO:0008509 (monoatomic anion transmembrane transporter activity), GO:0015103 (inorganic anion transmembrane transporter activity), GO:0015267 (channel activity), GO:0016594 (glycine binding), GO:0031406 (carboxylic acid binding), GO:0005216 (monoatomic ion channel activity), GO:0015108 (chloride transmembrane transporter activity), GO:0016597 (amino acid binding), GO:0005253 (monoatomic anion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0005254 (chloride channel activity), GO:0099095 (ligand-gated monoatomic anion channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005237 (inhibitory extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity), GO:0016933 (extracellularly glycine-gated ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0065007 (biological regulation), GO:0051179 (localization), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0051234 (establishment of localization), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0050794 (regulation of cellular process), GO:0001101 (response to acid chemical), GO:0045595 (regulation of cell differentiation), GO:1901700 (response to oxygen-containing compound), GO:1901698 (response to nitrogen compound), GO:0010033 (response to organic substance), GO:0048731 (system development), GO:0006810 (transport), GO:0045664 (regulation of neuron differentiation), GO:0007417 (central nervous system development), GO:0043200 (response to amino acid), GO:0007399 (nervous system development), GO:0010243 (response to organonitrogen compound), GO:0006811 (monoatomic ion transport)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0042734 (presynaptic membrane), GO:0045202 (synapse), GO:0098590 (plasma membrane region), GO:0005886 (plasma membrane), GO:0097060 (synaptic membrane)