Protein: Neuronal acetylcholine receptor subunit alpha-7 (nAChR7) (Nicotinic acetylcholine receptor subunit alpha-7) (P36544)
Organism: Homo sapiens (Human)
Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Subcellular location: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q05941}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27789755}; Multi-pass membrane protein {ECO:0000255}. Note=TMEM35A/NACHO promotes its trafficking to the cell membrane (PubMed:27789755). RIC3 promotes its trafficking to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q05941, ECO:0000269|PubMed:27789755}.
Sequence: MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
InterPro domains: - IPR038050: Neuronal acetylcholine receptor (homologous_superfamily) [231-501]
- IPR006201: Neurotransmitter-gated ion-channel (family) [1-489]
- IPR036734: Neurotransmitter-gated ion-channel ligand-binding domain superfamily (homologous_superfamily) [22-230]
- IPR018000: Neurotransmitter-gated ion-channel, conserved site (conserved_site) [150-164]
- IPR002394: Nicotinic acetylcholine receptor (family) [60-148]
- IPR036719: Neurotransmitter-gated ion-channel transmembrane domain superfamily (homologous_superfamily) [230-494]
- IPR006029: Neurotransmitter-gated ion-channel transmembrane domain (domain) [237-486]
- IPR006202: Neurotransmitter-gated ion-channel ligand-binding domain (domain) [27-230]
Interaction partners: - CHRNA7-FAM7A fusion protein
- Neuronal acetylcholine receptor subunit alpha-2
- Neuronal acetylcholine receptor subunit alpha-4
- Neuronal acetylcholine receptor subunit beta-4
- Neuronal acetylcholine receptor subunit beta-2
- Neuronal acetylcholine receptor subunit alpha-9
- Neuronal acetylcholine receptor subunit alpha-3
- Acetylcholine receptor subunit epsilon
- Neuronal acetylcholine receptor subunit beta-3
- Neuronal acetylcholine receptor subunit alpha-6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0060089 (molecular transducer activity), GO:0005488 (binding), GO:0005215 (transporter activity), GO:0022857 (transmembrane transporter activity), GO:0038023 (signaling receptor activity), GO:0005515 (protein binding), GO:0030594 (neurotransmitter receptor activity), GO:0004888 (transmembrane signaling receptor activity), GO:0015075 (monoatomic ion transmembrane transporter activity), GO:0022803 (passive transmembrane transporter activity), GO:0005216 (monoatomic ion channel activity), GO:0015464 (acetylcholine receptor activity), GO:0098960 (postsynaptic neurotransmitter receptor activity), GO:0022835 (transmitter-gated channel activity), GO:0015267 (channel activity), GO:0008324 (monoatomic cation transmembrane transporter activity), GO:0005261 (monoatomic cation channel activity), GO:0022824 (transmitter-gated monoatomic ion channel activity), GO:0022839 (monoatomic ion gated channel activity), GO:0022836 (gated channel activity), GO:0099529 (neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential), GO:1904315 (transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential), GO:0099094 (ligand-gated monoatomic cation channel activity), GO:0022834 (ligand-gated channel activity), GO:0015276 (ligand-gated monoatomic ion channel activity), GO:0022848 (acetylcholine-gated monoatomic cation-selective channel activity), GO:0005230 (extracellular ligand-gated monoatomic ion channel activity), GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0023057 (negative regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0009058 (biosynthetic process), GO:0042221 (response to chemical), GO:0055085 (transmembrane transport), GO:0048584 (positive regulation of response to stimulus), GO:0019222 (regulation of metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0051234 (establishment of localization), GO:0071704 (organic substance metabolic process), GO:0003008 (system process), GO:0007267 (cell-cell signaling), GO:0065008 (regulation of biological quality), GO:0044237 (cellular metabolic process), GO:0009719 (response to endogenous stimulus), GO:0050794 (regulation of cellular process), GO:0048583 (regulation of response to stimulus), GO:0009893 (positive regulation of metabolic process), GO:0051716 (cellular response to stimulus), GO:0023051 (regulation of signaling), GO:0048523 (negative regulation of cellular process), GO:0048585 (negative regulation of response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0007610 (behavior), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:1901615 (organic hydroxy compound metabolic process), GO:0009968 (negative regulation of signal transduction), GO:0010648 (negative regulation of cell communication), GO:1901564 (organonitrogen compound metabolic process), GO:1901576 (organic substance biosynthetic process), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0009636 (response to toxic substance), GO:0009966 (regulation of signal transduction), GO:0071495 (cellular response to endogenous stimulus), GO:0060255 (regulation of macromolecule metabolic process), GO:0044249 (cellular biosynthetic process), GO:1901700 (response to oxygen-containing compound), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0034220 (monoatomic ion transmembrane transport), GO:0098926 (postsynaptic signal transduction), GO:0010033 (response to organic substance), GO:0099536 (synaptic signaling), GO:1901360 (organic cyclic compound metabolic process), GO:1901698 (response to nitrogen compound), GO:2001023 (regulation of response to drug), GO:0010646 (regulation of cell communication), GO:0007611 (learning or memory), GO:0070887 (cellular response to chemical stimulus), GO:0019226 (transmission of nerve impulse), GO:0042391 (regulation of membrane potential), GO:0006810 (transport), GO:0010647 (positive regulation of cell communication), GO:0050877 (nervous system process), GO:0099177 (regulation of trans-synaptic signaling), GO:0035094 (response to nicotine), GO:1902074 (response to salt), GO:0071417 (cellular response to organonitrogen compound), GO:0050890 (cognition), GO:1905144 (response to acetylcholine), GO:1901362 (organic cyclic compound biosynthetic process), GO:0017085 (response to insecticide), GO:0071310 (cellular response to organic substance), GO:0019438 (aromatic compound biosynthetic process), GO:1902075 (cellular response to salt), GO:0050804 (modulation of chemical synaptic transmission), GO:1901617 (organic hydroxy compound biosynthetic process), GO:1901699 (cellular response to nitrogen compound), GO:0009308 (amine metabolic process), GO:0071702 (organic substance transport), GO:0095500 (acetylcholine receptor signaling pathway), GO:0010628 (positive regulation of gene expression), GO:1902532 (negative regulation of intracellular signal transduction), GO:0006811 (monoatomic ion transport), GO:0007600 (sensory perception), GO:0010468 (regulation of gene expression), GO:0001508 (action potential), GO:0018958 (phenol-containing compound metabolic process), GO:0007613 (memory), GO:1901566 (organonitrogen compound biosynthetic process), GO:0051899 (membrane depolarization), GO:0010243 (response to organonitrogen compound), GO:0019228 (neuronal action potential), GO:0099537 (trans-synaptic signaling), GO:1902533 (positive regulation of intracellular signal transduction), GO:0044271 (cellular nitrogen compound biosynthetic process), GO:1901701 (cellular response to oxygen-containing compound), GO:1902531 (regulation of intracellular signal transduction), GO:0043408 (regulation of MAPK cascade), GO:0006812 (monoatomic cation transport), GO:0006576 (biogenic amine metabolic process), GO:0009712 (catechol-containing compound metabolic process), GO:0099171 (presynaptic modulation of chemical synaptic transmission), GO:1905145 (cellular response to acetylcholine), GO:0098916 (anterograde trans-synaptic signaling), GO:0043410 (positive regulation of MAPK cascade), GO:0009309 (amine biosynthetic process), GO:0006816 (calcium ion transport), GO:0046189 (phenol-containing compound biosynthetic process), GO:0043409 (negative regulation of MAPK cascade), GO:0070374 (positive regulation of ERK1 and ERK2 cascade), GO:0042401 (biogenic amine biosynthetic process), GO:0007268 (chemical synaptic transmission), GO:0070373 (negative regulation of ERK1 and ERK2 cascade), GO:0030001 (metal ion transport), GO:0006584 (catecholamine metabolic process), GO:0009713 (catechol-containing compound biosynthetic process), GO:0070372 (regulation of ERK1 and ERK2 cascade), GO:0042417 (dopamine metabolic process), GO:0042423 (catecholamine biosynthetic process), GO:0007271 (synaptic transmission, cholinergic), GO:0042416 (dopamine biosynthetic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0044297 (cell body), GO:0098793 (presynapse), GO:0071944 (cell periphery), GO:0098796 (membrane protein complex), GO:0030054 (cell junction), GO:1990351 (transporter complex), GO:0043198 (dendritic shaft), GO:0098794 (postsynapse), GO:0043235 (receptor complex), GO:0036477 (somatodendritic compartment), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0098802 (plasma membrane signaling receptor complex), GO:0045202 (synapse), GO:0045211 (postsynaptic membrane), GO:0043025 (neuronal cell body), GO:0042734 (presynaptic membrane), GO:0098797 (plasma membrane protein complex), GO:0043197 (dendritic spine), GO:0098590 (plasma membrane region), GO:1902495 (transmembrane transporter complex), GO:0098857 (membrane microdomain), GO:0097447 (dendritic tree), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0099572 (postsynaptic specialization), GO:0097060 (synaptic membrane), GO:0045121 (membrane raft), GO:0099634 (postsynaptic specialization membrane), GO:0034702 (ion channel complex), GO:0098588 (bounding membrane of organelle), GO:0098690 (glycinergic synapse), GO:0014069 (postsynaptic density), GO:0030425 (dendrite), GO:0043005 (neuron projection), GO:0098981 (cholinergic synapse), GO:0098984 (neuron to neuron synapse), GO:0005892 (acetylcholine-gated channel complex), GO:0044853 (plasma membrane raft), GO:0032279 (asymmetric synapse), GO:0098839 (postsynaptic density membrane), GO:0030424 (axon), GO:0044309 (neuron spine)