Protein: Cilia- and flagella-associated protein 206 (Q6PE87)
Organism: Mus musculus (Mouse)
Function: Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract. Required for the establishment of radial spokes in sperm flagella.
Subcellular location: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:32376681}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32376681}.
Sequence: MPPTQAESVIKNIIREIGQECAAHGEIASETVVAFMVKAVVLDPSNGFNMDRTLIKTDVQKLVKLCVARLLDNKNPSLDTIKMQVYFDMNYTSREDFLEEHHRVLESRLGIVSREITDNRASAREELENLYRKIVSYVLLRSGLGSPTDIKIVREATAALQSVFPQAELATFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAILHEAIPTTTQHIDSQLQIAQDQAFRYTAILEKVTNNPLMAKELQPYMLKEALYNVRQYEIFLQTVLSDIITCAEEVEMMIKQLAAQLEQLKMAVKSKTAVPTSQVFPIFVALASLWMSFQDETVLISVLSNLTTNLELFLGTHELLFPEKVMLGLLDGVVVKSDLTRIEEHMEERVELADFRTQEWLFPETTANFNKLLIQYRGFCGYTFAVTDGLLLPGNPAIGILKYKEKYYTFSTRDAAYTFAENPDHYIHLIKEKAKKNAELIQLLELHQQFETLIPYSQMRDVDKHYIKPITKCDNGTQTDTHILPPTTMRTYEWNEWELRRKAIKLANLRQKITHSVQTDLSHMRRDNTSQVYPLKEASTQSKREGSSRVPRPQIFIAGLRGGQSKTTYGVKVNLTRAVDET
InterPro domains: - IPR021897: Cilia- and flagella-associated protein 206 (family) [5-620]
Interaction partners: - Radial spoke head protein 4 homolog A
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0050789 (regulation of biological process), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048869 (cellular developmental process), GO:0051641 (cellular localization), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0031503 (protein-containing complex localization), GO:0007389 (pattern specification process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0048646 (anatomical structure formation involved in morphogenesis), GO:0050794 (regulation of cellular process), GO:0021700 (developmental maturation), GO:0007017 (microtubule-based process), GO:0030659 (cytoplasmic vesicle membrane), GO:0044085 (cellular component biogenesis), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051649 (establishment of localization in cell), GO:0009799 (specification of symmetry), GO:0000226 (microtubule cytoskeleton organization), GO:0032886 (regulation of microtubule-based process), GO:0009880 (embryonic pattern specification), GO:0071695 (anatomical structure maturation), GO:0035295 (tube development), GO:0007018 (microtubule-based movement), GO:0009887 (animal organ morphogenesis), GO:0046907 (intracellular transport), GO:0003002 (regionalization), GO:0048469 (cell maturation), GO:0006810 (transport), GO:0016043 (cellular component organization), GO:0009790 (embryo development), GO:0010970 (transport along microtubule), GO:0030030 (cell projection organization), GO:0003341 (cilium movement), GO:0048562 (embryonic organ morphogenesis), GO:0048880 (sensory system development), GO:0007423 (sensory organ development), GO:0090596 (sensory organ morphogenesis), GO:0060632 (regulation of microtubule-based movement), GO:0099111 (microtubule-based transport), GO:0001578 (microtubule bundle formation), GO:0048666 (neuron development), GO:0022607 (cellular component assembly), GO:0009855 (determination of bilateral symmetry), GO:0006858 (extracellular transport), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0060972 (left/right pattern formation), GO:0072359 (circulatory system development), GO:0033043 (regulation of organelle organization), GO:0006996 (organelle organization), GO:0007507 (heart development), GO:0060541 (respiratory system development), GO:0070925 (organelle assembly), GO:0007368 (determination of left/right symmetry), GO:0051493 (regulation of cytoskeleton organization), GO:0048592 (eye morphogenesis), GO:0001654 (eye development), GO:0030031 (cell projection assembly), GO:0120036 (plasma membrane bounded cell projection organization), GO:0035082 (axoneme assembly), GO:0150063 (visual system development), GO:0001947 (heart looping), GO:0007010 (cytoskeleton organization), GO:0042461 (photoreceptor cell development), GO:0044782 (cilium organization), GO:0003351 (epithelial cilium movement involved in extracellular fluid movement), GO:0060271 (cilium assembly), GO:0043010 (camera-type eye development), GO:0120031 (plasma membrane bounded cell projection assembly), GO:0048593 (camera-type eye morphogenesis), GO:0044458 (motile cilium assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0097228 (sperm principal piece), GO:0097225 (sperm midpiece), GO:0120025 (plasma membrane bounded cell projection), GO:0043227 (membrane-bounded organelle), GO:0005929 (cilium), GO:0031514 (motile cilium), GO:0097729 (9+2 motile cilium), GO:0036126 (sperm flagellum)