Protein: L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (LDH muscle subunit) (LDH-M) (P04642)
Organism: Rattus norvegicus (Rat)
Function: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
Subcellular location: Cytoplasm.
Sequence: MAALKDQLIVNLLKEEQVPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLKTPKIVSSKDYSVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPQCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPQLGTDADKEQWKDVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGIKEDVFLSVPCILGQNGISDVVKVTLTPDEEARLKKSADTLWGIQKELQF
InterPro domains: - IPR001557: L-lactate/malate dehydrogenase (family) [17-332]
- IPR036291: NAD(P)-binding domain superfamily (homologous_superfamily) [3-160]
- IPR001236: Lactate/malate dehydrogenase, N-terminal (domain) [22-160]
- IPR022383: Lactate/malate dehydrogenase, C-terminal (domain) [164-324]
- IPR011304: L-lactate dehydrogenase (family) [20-331]
- IPR015955: Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (homologous_superfamily) [161-330]
- IPR018177: L-lactate dehydrogenase, active site (active_site) [190-196]
Interaction partners: - L-lactate dehydrogenase B chain
- Pyruvate kinase PKM
- Pyruvate kinase PKLR
- Pyruvate carboxylase, mitochondrial
- Aspartate aminotransferase, cytoplasmic
- Aspartate aminotransferase, mitochondrial
- L-lactate dehydrogenase C chain
- NADP-dependent malic enzyme
- Fructose-bisphosphate aldolase A
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0005515 (protein binding), GO:0016491 (oxidoreductase activity), GO:0042802 (identical protein binding), GO:0016614 (oxidoreductase activity, acting on CH-OH group of donors), GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0009987 (cellular process), GO:0044237 (cellular metabolic process), GO:0044281 (small molecule metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0044238 (primary metabolic process), GO:1901360 (organic cyclic compound metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0006139 (nucleobase-containing compound metabolic process), GO:0046483 (heterocycle metabolic process), GO:0055086 (nucleobase-containing small molecule metabolic process), GO:0006082 (organic acid metabolic process), GO:0019637 (organophosphate metabolic process), GO:0006725 (cellular aromatic compound metabolic process), GO:0034641 (cellular nitrogen compound metabolic process), GO:0006793 (phosphorus metabolic process), GO:0006753 (nucleoside phosphate metabolic process), GO:0043436 (oxoacid metabolic process), GO:0006796 (phosphate-containing compound metabolic process), GO:0072521 (purine-containing compound metabolic process), GO:0072524 (pyridine-containing compound metabolic process), GO:0019752 (carboxylic acid metabolic process), GO:0009117 (nucleotide metabolic process), GO:0019362 (pyridine nucleotide metabolic process), GO:0006163 (purine nucleotide metabolic process), GO:0046496 (nicotinamide nucleotide metabolic process), GO:0019674 (NAD metabolic process), GO:0043648 (dicarboxylic acid metabolic process), GO:0006734 (NADH metabolic process), GO:0006108 (malate metabolic process), GO:0006107 (oxaloacetate metabolic process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0032991 (protein-containing complex)