Protein: Radixin (cDNA, FLJ93349, Homo sapiens radixin (RDX), mRNA) (B0YJ88)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cell projection {ECO:0000256|ARBA:ARBA00004316}.
Sequence: MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
InterPro domains: - IPR035963: FERM superfamily, second domain (homologous_superfamily) [89-198]
- IPR019747: FERM conserved site (conserved_site) [58-205]
- IPR029071: Ubiquitin-like domain superfamily (homologous_superfamily) [2-87]
- IPR046810: Ezrin/radixin/moesin, alpha-helical domain (domain) [337-456]
- IPR000798: Ezrin/radixin/moesin-like (family) [17-581]
- IPR011174: Ezrin/radixin/moesin (family) [1-583]
- IPR018979: FERM, N-terminal (domain) [9-70]
- IPR000299: FERM domain (domain) [5-295]
- IPR019749: Band 4.1 domain (domain) [1-206]
- IPR014352: FERM/acyl-CoA-binding protein superfamily (homologous_superfamily) [83-199]
- IPR018980: FERM, C-terminal PH-like domain (domain) [210-299]
- IPR041789: ERM family, FERM domain C-lobe (domain) [200-296]
- IPR011259: Ezrin/radixin/moesin, C-terminal (domain) [508-583]
- IPR008954: Moesin tail domain superfamily (homologous_superfamily) [496-583]
- IPR019748: FERM central domain (domain) [90-206]
- IPR011993: PH-like domain superfamily (homologous_superfamily) [201-296]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0005515 (protein binding), GO:0003676 (nucleic acid binding), GO:0050839 (cell adhesion molecule binding), GO:0019899 (enzyme binding), GO:0008092 (cytoskeletal protein binding), GO:0003723 (RNA binding), GO:0045296 (cadherin binding), GO:0051117 (ATPase binding), GO:0003779 (actin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0032879 (regulation of localization), GO:0071840 (cellular component organization or biogenesis), GO:0051050 (positive regulation of transport), GO:0034260 (negative regulation of GTPase activity), GO:0033036 (macromolecule localization), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0048522 (positive regulation of cellular process), GO:0040017 (positive regulation of locomotion), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0065009 (regulation of molecular function), GO:0048523 (negative regulation of cellular process), GO:0040012 (regulation of locomotion), GO:0050790 (regulation of catalytic activity), GO:1903829 (positive regulation of protein localization), GO:0051049 (regulation of transport), GO:0051129 (negative regulation of cellular component organization), GO:2000145 (regulation of cell motility), GO:0032388 (positive regulation of intracellular transport), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0060341 (regulation of cellular localization), GO:0044092 (negative regulation of molecular function), GO:0030155 (regulation of cell adhesion), GO:0060255 (regulation of macromolecule metabolic process), GO:0060627 (regulation of vesicle-mediated transport), GO:0051668 (localization within membrane), GO:0032970 (regulation of actin filament-based process), GO:2000147 (positive regulation of cell motility), GO:0044087 (regulation of cellular component biogenesis), GO:0009894 (regulation of catabolic process), GO:0009888 (tissue development), GO:0007162 (negative regulation of cell adhesion), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0016043 (cellular component organization), GO:0080090 (regulation of primary metabolic process), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0009896 (positive regulation of catabolic process), GO:0032535 (regulation of cellular component size), GO:0043086 (negative regulation of catalytic activity), GO:0022604 (regulation of cell morphogenesis), GO:1903391 (regulation of adherens junction organization), GO:0031344 (regulation of cell projection organization), GO:0042176 (regulation of protein catabolic process), GO:0051246 (regulation of protein metabolic process), GO:0051336 (regulation of hydrolase activity), GO:0022407 (regulation of cell-cell adhesion), GO:0032956 (regulation of actin cytoskeleton organization), GO:0010628 (positive regulation of gene expression), GO:0032880 (regulation of protein localization), GO:0030334 (regulation of cell migration), GO:1903651 (positive regulation of cytoplasmic transport), GO:1902115 (regulation of organelle assembly), GO:0010468 (regulation of gene expression), GO:0060491 (regulation of cell projection assembly), GO:0030855 (epithelial cell differentiation), GO:1902903 (regulation of supramolecular fiber organization), GO:0072657 (protein localization to membrane), GO:0032231 (regulation of actin filament bundle assembly), GO:0002064 (epithelial cell development), GO:2000641 (regulation of early endosome to late endosome transport), GO:0051247 (positive regulation of protein metabolic process), GO:0030335 (positive regulation of cell migration), GO:0033043 (regulation of organelle organization), GO:0045732 (positive regulation of protein catabolic process), GO:0008104 (protein localization), GO:0022408 (negative regulation of cell-cell adhesion), GO:0060429 (epithelium development), GO:0032386 (regulation of intracellular transport), GO:0008360 (regulation of cell shape), GO:0034111 (negative regulation of homotypic cell-cell adhesion), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0051346 (negative regulation of hydrolase activity), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:1990778 (protein localization to cell periphery), GO:0008361 (regulation of cell size), GO:0045446 (endothelial cell differentiation), GO:0043087 (regulation of GTPase activity), GO:1903649 (regulation of cytoplasmic transport), GO:0001885 (endothelial cell development), GO:0072659 (protein localization to plasma membrane), GO:0003158 (endothelium development), GO:0110053 (regulation of actin filament organization), GO:0034110 (regulation of homotypic cell-cell adhesion), GO:0061028 (establishment of endothelial barrier), GO:0045792 (negative regulation of cell size), GO:1900027 (regulation of ruffle assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005576 (extracellular region), GO:0005615 (extracellular space), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0070161 (anchoring junction), GO:0070062 (extracellular exosome), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0043230 (extracellular organelle), GO:0016324 (apical plasma membrane), GO:0030055 (cell-substrate junction), GO:0065010 (extracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005925 (focal adhesion), GO:1903561 (extracellular vesicle)