wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Protease (P74305)
Organism: Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
Function: Not known
Sequence: MPLLVFRSLSRCLLVTALILVLHGPGLWSHPAIAADLAPTNNRNSQTLTPYLNRAIQRITEFQLDNGLKFIVMENNEAPVVSFYTYFDVGGVDEPVGKTGVAHFLEHMAFKGTERIGTKDFTQEQQLLDQLDQVFAQITTARAKGDKTGEQKLQEQFKQIQQQAQDLIKQNEFGQIIQMAGGVGLNAATSADATFYFYSLPSNKLELWMSLESERFLEPVFREFYQEQEVILEERRMRTENNPVGQMVEEFLDTAFTKHPYRRPVIGYDEDIRNLSRQDVTDFYEKYYIPGNMTIAVVGDVKVDQVKSLAQKYFGRFPQRPPTPQVTVVEPPQTQQKEINLTLPSQPWYFEGYHSPAFDDPDSAVFDVMTTILSSGRTSRLYQSLVEEKQLALMAQGFNGFPADKFPNLLMFYAQSAPGRSLDDLSEALHGEIERLKMEPVTPEELERAQNLLQTSALQSLNSNMGMAQLLVKYNVRTGDWRNLFARLEAIAAVTPEDIQRVAQETFRPENSTIGRILPESNRQ
InterPro domains: - IPR007863: Peptidase M16, C-terminal (domain) [274-453]
- IPR050361: Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex (family) [57-515]
- IPR001431: Peptidase M16, zinc-binding site (binding_site) [90-113]
- IPR011765: Peptidase M16, N-terminal (domain) [71-266]
- IPR011249: Metalloenzyme, LuxS/M16 peptidase-like (homologous_superfamily) [57-522]
Interaction partners: - Hydrogenase subunit
- Processing protease
- Cytochrome b6
- Hydrogenase subunit
- NAD
- NAD
- Cobalt-precorrin-8 methylmutase
- Cytochrome b6/f complex iron-sulfur subunit
- Cytochrome b6-f complex iron-sulfur subunit 2
- Cytochrome b6-f complex iron-sulfur subunit 1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0140096 (catalytic activity, acting on a protein), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0008233 (peptidase activity), GO:0004175 (endopeptidase activity), GO:0008237 (metallopeptidase activity), GO:0004222 (metalloendopeptidase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0008152 (metabolic process), GO:0044238 (primary metabolic process), GO:0006807 (nitrogen compound metabolic process), GO:0071704 (organic substance metabolic process), GO:0043170 (macromolecule metabolic process), GO:1901564 (organonitrogen compound metabolic process), GO:0019538 (protein metabolic process), GO:0006508 (proteolysis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0031975 (envelope), GO:0042597 (periplasmic space), GO:0030313 (cell envelope), GO:0030288 (outer membrane-bounded periplasmic space)
Protein: Minor ampullate spidroin (K4MTL7)
Organism: Araneus ventricosus (Orbweaver spider) (Epeira ventricosa)
Function: Not known
Sequence: MQLPTRLSFFFLVLFIQGFLSQSQPIWTNPNAAMTMTNNLVQCASRSGVLTADQMDDMGMMADSVNSQMQKMGPNPPQHRLRAMNTAMAAEVAEVVATSPPQSYSAVLNTIGACLRESMMQATGSVDNAFTNEVMQLVKMLSADSANEVSTASASGASYATSTSSAVSSSQATGYSTAAGYGNAAGAGAGAAAAVSGGAGSAGGYGEGAGAGVRSGAGASAGAAGGYGRATGAGAGGAAAAGASGYGGSYGAGAGAGAAGAGGASAYGAGIGGGYGAGAADAYGGGASAGAGAGAGAGVSGGYGRAAGAGAAAAAGANGYGGSYDAGVGAGTAGAGAGAGASGGYGGGAGEGAGAAAAAGAGAGGAGGYGGGAGSGAGAVARAGAGGAGGYGSGIGGGYGSGAGAAAGAGAGGAGAYGGGYGTGAGAGARGADSAGAAAGYGGGVGTGTGSSAGYGRGAGAGAGAGAAAGSGAGAAGGYGGGYGAGAGAGAGAGGATGNRAGDAFAQVFSQNVINSGVITSTTVTKNSAQAAASSMVSTAAKSLGLDENTARSMANAMSSYAAAMAKSFRNSDEFIRNMSYQMGRMLSNAGAINESTASAAASSASSTVTETVRTYGPAAIFSGAGAGGAGGYAQGYGAGAGAGAGAGTGAGGAGGYGQGYGAGSGAGAGGAGGYGAGAGAGAGAGGASGYGQGYGDGAGAGAGAAAAAGAAAGARGAGGYGGGAGDGAGAGAGAGAAGGYGQGYGAGEGAGAGAGAGGAGGYGAGAGAGGAGGYGQSYGDGAAAAAGSGAGAGGSGGYGAGAGAGAGAGAGSGAGAAGGYGGGAGAGVGAGGAGGYDQGYGAGAGAGSGAGAGGAGGYGGGAGAGADAGAGGAGGYGGGAGAGAGARAGAGGVGGYGQSYGAGAGAGAGVGAGGAGAGGADGYGQGYGAGAGTGAGDAGGYGGGAGAGASAGAGGYGGGAGAGGVGVYGKGYGSGSGAGAAAAAGAGGATGNRAGDAFAQVFSQNVINSGVITSTTVTKNSAQAAASSMVSTAAKSLGLDENTARSMANAMSSYAAAMAKSFRNSDEFIRNMSYQMGRMLSNAGAINESTASAAASSASSTVTETVRTYGPAAIFSGAGAGGAGGYAQGYGAGAGAGAGAGTGAGGAGGYGQGYGAGSGAGAGGAGGYGAGAGAGAGAGDASGYGQGYGDGAGAGAGAAAAAGAAAGARGAGGYGGGAGAGAGAGAGAAGGYGQGYGAGAGEGAGAGAGAGAVAGAGAAAAAGAGAGAGGAEGYGAGAGAGGAGGYGQSYGDGAAAAAGSGAGAGGSGGYGAGAGAGSGAGAAGGYGGGAGAGVGAGGEGGYDQGYGAGAGAGSGGGAGGAGGYGGGAGAGSGGGAGGAGGYGGGAGAGAGAGAGGAGGYGGGAGAGTGARAGAGGVGGYGQSYGAGASAAAGAGVGAGGAGAGGAGGYGQGYGAGAGIGAGDAGGYGGGAGAGASAGAGGYGGGAGAGAGGVGGYGKGYGAGSGAGAAAAAGAGAGSAGGYGRGDGAGAGGASGYGQGYGAGAAAGAAATAGAGASVAGGYGGGAGAAAGAGAGGYGGGYGAVAGSGAGAAAAASSGAGGAAGYGRGYGAGSGAGAGAGTVAAYGGAGGVATSSSSATASGSRIVTSGGYGYGTSAAAGAGVAAGSYAGAVNRLSSAEAASRVSSNIAAIASGGASALPSVISNIYSGVVASGVSSNEALIQALLELLSALVHVLSSASIGNVSSVGVDSTLNVVQDSVGQYVG
InterPro domains: - IPR043070: Spidroin, repetitive domain (homologous_superfamily) [502-1125]
- IPR038542: Spidroin, C-terminal domain superfamily (homologous_superfamily) [1658-1766]
- IPR031913: Spidroin, N-terminal (domain) [26-147]
- IPR021001: Spidroin, C-terminal (domain) [1672-1747]
- IPR038243: Spidroin, N-terminal domain superfamily (homologous_superfamily) [31-153]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0042802 (identical protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050789 (regulation of biological process), GO:0048519 (negative regulation of biological process), GO:0065007 (biological regulation), GO:0048523 (negative regulation of cellular process), GO:0050794 (regulation of cellular process), GO:0008285 (negative regulation of cell population proliferation), GO:0042127 (regulation of cell population proliferation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0030312 (external encapsulating structure), GO:0031012 (extracellular matrix)
Protein: Protein-serine/threonine kinase (EC 2.7.11.-) (O82423)
Organism: Zea mays (Maize)
Function: Not known
Subcellular location: Mitochondrion matrix {ECO:0000256|RuleBase:RU366032}.
Sequence: MASEPVARAVAEEVARWGAMRQTGVSLRYMMEFGARPTERTLLLAAQFLHKELPIRIARRALDLDSLPFGLSTKPAILKVKDWYVESFREIRSFPEVRNQKDELAFTQMIKMIRVRHTNVVPAIALGVQQLKKDLGGPKAFPPGIHEIHQFLDRFYMSRIGIRMLIGQHVALHDPDPEPGVIGLINTKMSPMTVARIASEDARAICMREYGSSPDVDIYGDPGFTFPYVTPHLHLMIFELVKNSLRAVQERYMDSDKLAPPVRIIVADGAEDVTIKISDEGGGIPRSGLSRIFTYLYSTAENPPDLDGHNEGVTMAGYGYGIPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLGDSEEPLP
InterPro domains: - IPR036890: Histidine kinase/HSP90-like ATPase superfamily (homologous_superfamily) [188-362]
- IPR003594: Histidine kinase/HSP90-like ATPase domain (domain) [228-356]
- IPR018955: Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal (domain) [25-185]
- IPR039028: PDK/BCKDK protein kinase (family) [7-362]
- IPR005467: Histidine kinase domain (domain) [233-356]
- IPR004358: Signal transduction histidine kinase-related protein, C-terminal (domain) [273-353]
- IPR036784: Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily (homologous_superfamily) [1-178]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0036094 (small molecule binding), GO:0016740 (transferase activity), GO:1901363 (heterocyclic compound binding), GO:0043167 (ion binding), GO:0097159 (organic cyclic compound binding), GO:0140096 (catalytic activity, acting on a protein), GO:0097367 (carbohydrate derivative binding), GO:1901265 (nucleoside phosphate binding), GO:0016772 (transferase activity, transferring phosphorus-containing groups), GO:0004672 (protein kinase activity), GO:0043168 (anion binding), GO:0000166 (nucleotide binding), GO:0032553 (ribonucleotide binding), GO:0035639 (purine ribonucleoside triphosphate binding), GO:0017076 (purine nucleotide binding), GO:0016301 (kinase activity), GO:0016773 (phosphotransferase activity, alcohol group as acceptor), GO:0032555 (purine ribonucleotide binding), GO:0005524 (ATP binding), GO:0032559 (adenyl ribonucleotide binding), GO:0030554 (adenyl nucleotide binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0065009 (regulation of molecular function), GO:0044092 (negative regulation of molecular function), GO:0050790 (regulation of catalytic activity), GO:0043086 (negative regulation of catalytic activity)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0005759 (mitochondrial matrix), GO:0070013 (intracellular organelle lumen), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Leucine rich repeats and calponin homology domain containing 3 (E9PD99)
Organism: Homo sapiens (Human)
Function: Not known
Sequence: MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRAELAELPLIRLDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEELYSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGSLVVTNGGVEHDLDQIDYIDSCTAEEEEAEGSPVKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTRREAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQHTDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAAIQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELIDQLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV
InterPro domains: - IPR001715: Calponin homology domain (domain) [498-611]
- IPR032675: Leucine-rich repeat domain superfamily (homologous_superfamily) [58-151]
- IPR036872: CH domain superfamily (homologous_superfamily) [495-622]
- IPR050216: Leucine-rich repeat domain-containing protein (family) [62-339]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0006996 (organelle organization), GO:0007010 (cytoskeleton organization), GO:0032185 (septin cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm)
Protein: Putative serine protease K12H4.7 (EC 3.4.-.-) (P34528)
Organism: Caenorhabditis elegans
Function: Not known
Sequence: MKTLLAVLLAACVLTQVLSAPSNEQRVRRNMIRGRPRGGMKKTPPMSSVSHMINFDNVVSSTFTQTLDHFDSSVGKTFQQRYYHNNQWYKAGGPAFLMLGGEGPESSYWVSYPGLEITNLAAKQGAWVFDIEHRFYGETHPTSDMSVPNLKYLSSAQAIEDAAAFIKAMTAKFPQLANAKWVTFGGSYSGALAAWTRAKHPELVYAAVGSSGPVQAEVDFKEYLEVVQNSITRNSTECAASVTQGFNLVASLLQTSDGRKQLKTAFHLCQDIQMDDKSLKYFWETVYSPYMEVVQYSGDAAGSFATQLTISHAICRYHINTKSTPLQKLKQVNDYFNQVSGYFGCNDIDYNGFISFMKDETFGEAQSDRAWVWQTCTEFGYYQSTSSATAGPWFGGVSNLPAQYYIDECTAIYGAAYNSQEVQTSVDYTNQYYGGRDNLNTDRILLPNGDIDPWHALGKLTSSNSNIVPVVINGTAHCADMYGASSLDSMYLTNARQRISDVLDGWLHAN
InterPro domains: - IPR029058: Alpha/Beta hydrolase fold (homologous_superfamily) [63-507]
- IPR008758: Peptidase S28 (family) [65-499]
- IPR042269: Serine carboxypeptidase S28, SKS domain (homologous_superfamily) [222-399]
Interaction partners: - Peptidase A1 domain-containing protein
- C-type LECtin
- C-type LECtin
- Carboxypeptidase
- CUB_2 domain-containing protein
- Peptidase M20 dimerisation domain-containing protein
- DUF19 domain-containing protein
- DUF19 domain-containing protein
- CUB-like domain-containing protein
- Aspartic protease 6
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0002376 (immune system process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0045087 (innate immune response), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0016020 (membrane), GO:0098857 (membrane microdomain), GO:0045121 (membrane raft)
Protein: Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain) (P63211)
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Subcellular location: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Sequence: MPVINIEDLTEKDKLKMEVDQLKKEVTLERMLVSKCCEEVRDYVEERSGEDPLVKGIPEDKNPFKELKGGCVIS
InterPro domains: - IPR015898: G-protein, gamma subunit-like domain (domain) [5-74]
- IPR036284: G-protein gamma-like domain superfamily (homologous_superfamily) [1-66]
- IPR001770: G-protein, gamma subunit (family) [1-73]
Interaction partners: - Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein subunit beta-4
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- Guanine nucleotide-binding protein G
- C-C chemokine receptor type 5
- Rhodopsin
- Phosducin
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
- Guanine nucleotide-binding protein G
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0009987 (cellular process), GO:0023052 (signaling), GO:0065007 (biological regulation), GO:0051716 (cellular response to stimulus), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0050794 (regulation of cellular process)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0071944 (cell periphery), GO:0016020 (membrane), GO:0005886 (plasma membrane)
Protein: CEA cell adhesion molecule 3 (A0A0G2JW44)
Organism: Rattus norvegicus (Rat)
Function: Not known
Sequence: MELSSVLPCKRCTPWRGLLLTASLLTCWLLPTTAQVSIESLPPQVVEGENVLLRVDNLPENLIAFVWYKGLTNMSLGVALYSLTYNVTVTGPVHSGRETLYSNGSLWIQNVTQKDTGFYTLRTISNHGEIVSNTSLHLHVYSCFMSYAGPPTSAQLTVESAPTSVAEGASVLLLAHNLPENLRAIFWYKGAILFKDLEVARYVIGTNSSVPGPAHSGRETMHSNGSLLLQNVTRNDAGFYTLRTLSTDLKAKVVHVQLQVNTSSCCDPLTPAPLTIDPVPRHAAKGESVLLQVRNLPEDLRMFIWFKSVYTSQIFKIAEYSRAINYVFRGPAHSGRETVYTNGSLLLQDATEKDTGLYTLQIIYRNFKIETAHVQVSVHKPVAQPFIRVTESSVRVKSSVVLTCLSADTGTSIQWLFNNQNLRLTQRMLLSQTKCQLSIDPV
InterPro domains: - IPR013106: Immunoglobulin V-set domain (domain) [41-379]
- IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [35-441]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [37-442]
- IPR007110: Immunoglobulin-like domain (domain) [381-442]
- IPR003599: Immunoglobulin domain subtype (domain) [40-379]
- IPR050831: Carcinoembryonic antigen-related cell adhesion (family) [265-441]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097367 (carbohydrate derivative binding), GO:1901681 (sulfur compound binding), GO:0005515 (protein binding), GO:0043395 (heparan sulfate proteoglycan binding), GO:0043394 (proteoglycan binding)
Biological Process (BP): GO:0008150 (biological process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0044706 (multi-multicellular organism process), GO:0044703 (multi-organism reproductive process), GO:0007565 (female pregnancy)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0009986 (cell surface)
Protein: BBSome complex assembly protein BBS10 (Bardet-Biedl syndrome 10 protein) (Q8TAM1)
Organism: Homo sapiens (Human)
Function: Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
Subcellular location: Cell projection, cilium {ECO:0000269|PubMed:19190184}. Note=Located within the basal body of the primary cilium of differentiating preadipocytes. {ECO:0000269|PubMed:19190184}.
Sequence: MLSSMAAAGSVKAALQVAEVLEAIVSCCVGPEGRQVLCTKPTGEVLLSRNGGRLLEALHLEHPIARMIVDCVSSHLKKTGDGAKTFIIFLCHLLRGLHAITDREKDPLMCENIQTHGRHWKNCSRWKFISQALLTFQTQILDGIMDQYLSRHFLSIFSSAKERTLCRSSLELLLEAYFCGRVGRNNHKFISQLMCDYFFKCMTCKSGIGVFELVDDHFVELNVGVTGLPVSDSRIIAGLVLQKDFSVYRPADGDMRMVIVTETIQPLFSTSGSEFILNSEAQFQTSQFWIMEKTKAIMKHLHSQNVKLLISSVKQPDLVSYYAGVNGISVVECLSSEEVSLIRRIIGLSPFVPPQAFSQCEIPNTALVKFCKPLILRSKRYVHLGLISTCAFIPHSIVLCGPVHGLIEQHEDALHGALKMLRQLFKDLDLNYMTQTNDQNGTSSLFIYKNSGESYQAPDPGNGSIQRPYQDTVAENKDALEKTQTYLKVHSNLVIPDVELETYIPYSTPTLTPTDTFQTVETLTCLSLERNRLTDYYEPLLKNNSTAYSTRGNRIEISYENLQVTNITRKGSMLPVSCKLPNMGTSQSYLSSSMPAGCVLPVGGNFEILLHYYLLNYAKKCHQSEETMVSMIIANALLGIPKVLYKSKTGKYSFPHTYIRAVHALQTNQPLVSSQTGLESVMGKYQLLTSVLQCLTKILTIDMVITVKRHPQKVHNQDSEDEL
InterPro domains: - IPR027410: TCP-1-like chaperonin intermediate domain superfamily (homologous_superfamily) [178-427]
- IPR042619: BBSome complex assembly protein BBS10 (family) [4-722]
- IPR027409: GroEL-like apical domain superfamily (homologous_superfamily) [237-390]
- IPR002423: Chaperonin Cpn60/GroEL/TCP-1 family (family) [21-427]
- IPR027413: GroEL-like equatorial domain superfamily (homologous_superfamily) [5-718]
Interaction partners: - Chaperonin-containing T-complex member BBS12
- BBSome complex member BBS7
- T-complex protein 1 subunit beta
- BBSome complex member BBS2
- T-complex protein 1 subunit epsilon
- BBSome complex member BBS1
- BBSome complex member BBS5
- Protein PTHB1
- BBSome complex member BBS4
- T-complex protein 1 subunit gamma
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)
Protein: EG:131F2.2 protein (O76875)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: MAKGPEQLHPQQQMQQQKRGRNKKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSATTSATSSPTNSPTSYPRANGNRKRIEAALEWRREQELGRQNANFLVPPLRQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIEIFKCMPHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSECESSNSSSSSAGEAALGLELKYCHFVPVERSLSKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHGRWTCCNEGEESSPGCCLGDRHVWSGSVVGVNGPYYDFVRTEHRGSGEDEPAVYALDCEMSYTGRGLDVTKVSLVALNGQLVYEHFVRPVCDIIDYNTQYSGITETDLCSGAKSLAEVQRDLLQLITADTILIGHGLENDLRALRLVHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMELMLWRVNRELDPAWSWDD
InterPro domains: - IPR012337: Ribonuclease H-like superfamily (homologous_superfamily) [349-502]
- IPR013520: Ribonuclease H-like domain (domain) [347-508]
- IPR047021: RNA exonuclease REXO1/REXO3/REXO4-like (family) [22-507]
- IPR034922: RNA exonuclease 1-like, exonuclease domain (domain) [349-500]
- IPR036397: Ribonuclease H superfamily (homologous_superfamily) [345-510]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0140640 (catalytic activity, acting on a nucleic acid), GO:0016787 (hydrolase activity), GO:0140098 (catalytic activity, acting on RNA), GO:0016788 (hydrolase activity, acting on ester bonds), GO:0004518 (nuclease activity), GO:0004540 (ribonuclease activity), GO:0004532 (exoribonuclease activity), GO:0004527 (exonuclease activity), GO:0008408 (3'-5' exonuclease activity), GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters), GO:0016796 (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters), GO:0000175 (3'-5'-RNA exonuclease activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0000003 (reproduction), GO:0032501 (multicellular organismal process), GO:0022414 (reproductive process), GO:0007343 (egg activation), GO:0019953 (sexual reproduction), GO:0001775 (cell activation), GO:0009566 (fertilization), GO:0007338 (single fertilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)