wanglab/bioreason-pro-rl-reasoning-data huggingface dataset:
Protein: Septin 9 (K7ER14)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
Sequence: MGSFRTSKMPKPAEAPTAPSPAQTLENSEPAPVSQLQSRLEPKPQPPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEI
InterPro domains: - IPR027417: P-loop containing nucleoside triphosphate hydrolase (homologous_superfamily) [92-159]
- IPR030379: Septin-type guanine nucleotide-binding (G) domain (domain) [112-159]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003824 (catalytic activity), GO:0016787 (hydrolase activity), GO:0005515 (protein binding), GO:0042802 (identical protein binding), GO:0016817 (hydrolase activity, acting on acid anhydrides), GO:0016818 (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides), GO:0016462 (pyrophosphatase activity), GO:0017111 (ribonucleoside triphosphate phosphatase activity), GO:0003924 (GTPase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0051716 (cellular response to stimulus), GO:0071840 (cellular component organization or biogenesis), GO:0050794 (regulation of cellular process), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0051128 (regulation of cellular component organization), GO:0032970 (regulation of actin filament-based process), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0043933 (protein-containing complex organization), GO:0006996 (organelle organization), GO:1902115 (regulation of organelle assembly), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0051493 (regulation of cytoskeleton organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0017004 (cytochrome complex assembly), GO:0008535 (respiratory chain complex IV assembly), GO:0033617 (mitochondrial cytochrome c oxidase assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0043229 (intracellular organelle), GO:0005783 (endoplasmic reticulum), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)
Protein: Mbd3 protein (B2RZ64)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
Sequence: RPAGGGGPRDGTAAASGGGGEGNRAGDEPGGRDLQKRRRHRRRQARRRAESRGAMERKSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEEPEPERV
InterPro domains: - IPR032343: Methyl-CpG-binding domain protein 2/3, p55-binding region (domain) [101-170]
- IPR025884: Methyl-CpG binding protein 2/3, C-terminal domain (domain) [175-265]
- IPR016177: DNA-binding domain superfamily (homologous_superfamily) [51-118]
- IPR001739: Methyl-CpG DNA binding (domain) [18-98]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0003682 (chromatin binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0009605 (response to external stimulus), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0042221 (response to chemical), GO:0019222 (regulation of metabolic process), GO:0050794 (regulation of cellular process), GO:0007568 (aging), GO:0009991 (response to extracellular stimulus), GO:0060322 (head development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0060255 (regulation of macromolecule metabolic process), GO:0009790 (embryo development), GO:0031323 (regulation of cellular metabolic process), GO:1901700 (response to oxygen-containing compound), GO:0080090 (regulation of primary metabolic process), GO:0010033 (response to organic substance), GO:0007420 (brain development), GO:0048568 (embryonic organ development), GO:0007399 (nervous system development), GO:0032355 (response to estradiol), GO:0051052 (regulation of DNA metabolic process), GO:0033993 (response to lipid), GO:0031667 (response to nutrient levels), GO:0072359 (circulatory system development), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0007417 (central nervous system development), GO:0014070 (response to organic cyclic compound), GO:0007507 (heart development), GO:0044030 (regulation of DNA methylation)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0000785 (chromatin), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus), GO:0005694 (chromosome)
Protein: Thymosin beta (Q45QT2)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR001828}.
Sequence: MSDKPNLEEVTSFDKTKLKKTETQEKNPLPSKETIEQEKQAGSS
InterPro domains: - IPR001152: Beta-thymosin (family) [1-44]
- IPR038386: Beta-thymosin superfamily (homologous_superfamily) [2-41]
Interaction partners: - Actin alpha 1, skeletal muscle b.
- Actin, cytoplasmic 1
- Actin, cytoplasmic 2
- Thymosin beta
- Thymosin beta
- Wilms tumor protein homolog
- T-box transcription factor 18.
- Profilin
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0008092 (cytoskeletal protein binding), GO:0003779 (actin binding), GO:0003785 (actin monomer binding)
Biological Process (BP): GO:0008150 (biological process), GO:0002376 (immune system process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0050789 (regulation of biological process), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0048583 (regulation of response to stimulus), GO:0009605 (response to external stimulus), GO:0006950 (response to stress), GO:0051707 (response to other organism), GO:0006955 (immune response), GO:0009607 (response to biotic stimulus), GO:0006952 (defense response), GO:0032101 (regulation of response to external stimulus), GO:0043207 (response to external biotic stimulus), GO:0080134 (regulation of response to stress), GO:0009617 (response to bacterium), GO:0006959 (humoral immune response), GO:0098542 (defense response to other organism), GO:0031347 (regulation of defense response), GO:0019730 (antimicrobial humoral response), GO:0050727 (regulation of inflammatory response), GO:1903034 (regulation of response to wounding), GO:0042742 (defense response to bacterium), GO:0019731 (antibacterial humoral response)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region)
Protein: Cellular retinoic acid binding protein I (B0FLN8)
Organism: Gallus gallus (Chicken)
Function: Not known
Sequence: MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKIGESFEEETVDGRKCRSLATWENENKIYCKQTLIEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE
InterPro domains: - IPR000463: Cytosolic fatty-acid binding (domain) [4-136]
- IPR012674: Calycin (homologous_superfamily) [2-136]
- IPR031259: Intracellular lipid binding protein (family) [1-136]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [5-137]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0036094 (small molecule binding), GO:0043167 (ion binding), GO:0008289 (lipid binding), GO:0043168 (anion binding), GO:0043177 (organic acid binding), GO:0019840 (isoprenoid binding), GO:0031406 (carboxylic acid binding), GO:0005501 (retinoid binding), GO:0033293 (monocarboxylic acid binding), GO:0001972 (retinoic acid binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0044419 (biological process involved in interspecies interaction between organisms), GO:0009605 (response to external stimulus), GO:0051707 (response to other organism), GO:0009607 (response to biotic stimulus), GO:0006950 (response to stress), GO:0006952 (defense response), GO:0009617 (response to bacterium), GO:0098542 (defense response to other organism), GO:0043207 (response to external biotic stimulus), GO:0042742 (defense response to bacterium), GO:0050829 (defense response to Gram-negative bacterium)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005829 (cytosol), GO:0005622 (intracellular anatomical structure), GO:0005737 (cytoplasm), GO:0042995 (cell projection), GO:0120025 (plasma membrane bounded cell projection), GO:0043005 (neuron projection), GO:0030424 (axon), GO:0070852 (cell body fiber)
Protein: Ankyrin repeat and SOCS box protein 11 (ASB-11) (d-asb11) (Q70X92)
Organism: Danio rerio (Zebrafish) (Brachydanio rerio)
Function: Not known
Subcellular location: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8WXH4}.
Sequence: MAVVHAEGNVWIKQWDHRFHMYGGQTCSPLMAGSWDDRTPLHDAALQGRLLPLRRLLSQGYNVGMATLDGITALHEACVGGHFTCAKLLLEHGADANAVTFDGATPLFSACCSGNPALVSLILTHSSAHHPAHLLCSPLHEAAKRGHTACVELLLSHGVNVDMELPSVGTALYCACEVKSTDCVLTLLILGADVQCGRGLDTPLHAACRVGGAKEAELLLEHGADRTSRNSEGKTPLDLTSDQSIKHLLQTAGTCSLSQLCRWCIRRSLGQKGLNKTKTLCLPHMLHNYLLYH
InterPro domains: - IPR036036: SOCS box-like domain superfamily (homologous_superfamily) [253-292]
- IPR036770: Ankyrin repeat-containing domain superfamily (homologous_superfamily) [26-256]
- IPR002110: Ankyrin repeat (repeat) [36-231]
- IPR051573: Ankyrin repeat and SOCS box domain-containing protein (family) [27-292]
- IPR001496: SOCS box domain (domain) [244-293]
Interaction partners: - Delta-like protein A
- Ankyrin repeat and SOCS box-containing 6.
- Leucine-rich repeat-containing 20
- Leucine-rich repeat-containing protein 14B
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0003824 (catalytic activity), GO:0016740 (transferase activity), GO:0140096 (catalytic activity, acting on a protein), GO:0019787 (ubiquitin-like protein transferase activity), GO:0004842 (ubiquitin-protein transferase activity), GO:0061659 (ubiquitin-like protein ligase activity), GO:0061630 (ubiquitin protein ligase activity)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0048583 (regulation of response to stimulus), GO:0023051 (regulation of signaling), GO:0023056 (positive regulation of signaling), GO:0048584 (positive regulation of response to stimulus), GO:0050794 (regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0009967 (positive regulation of signal transduction), GO:0010647 (positive regulation of cell communication), GO:0009966 (regulation of signal transduction), GO:0010646 (regulation of cell communication), GO:1902533 (positive regulation of intracellular signal transduction), GO:1902531 (regulation of intracellular signal transduction), GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling), GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031974 (membrane-enclosed lumen), GO:0043229 (intracellular organelle), GO:0043233 (organelle lumen), GO:0043227 (membrane-bounded organelle), GO:0043228 (non-membrane-bounded organelle), GO:0070013 (intracellular organelle lumen), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0031981 (nuclear lumen), GO:0005730 (nucleolus), GO:0005634 (nucleus)
Protein: Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15) (Q61414)
Organism: Mus musculus (Mouse)
Function: In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5.
Sequence: MATTFLQTSSTFGGSSTRGASLRAGGGSFGGGSLYGGGGSRSISASSARFVSSGAGGGFGGGMSCGFGGGFGGGFGGGFGGGFGDFGGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEQANTELEVKIRDWYQKQSPASPDRDYSHYFKTMEEIRDKILAATIDNSRVVLEIDNARLAADDFRLKYENELTLRQGVEADINGLRRVLDELTLARTDLEMQIEQLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRMLAEMREQYEAIAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTLQGLEIELQSQLSMKAGLENSLAEVECRYATQLQQIQGVITGLETQLSELRCEMEAQNQEYNMLLDIKTRLEQEIATYRNLLEGQDAKMAGIGVREGSSGGGGSSSSSSNFHISVEESVDGKVVSSRKREI
InterPro domains: - IPR018039: Intermediate filament protein, conserved site (conserved_site) [396-404]
- IPR002957: Keratin, type I (family) [12-447]
- IPR039008: Intermediate filament, rod domain (domain) [97-410]
Interaction partners: - Keratin, type II cytoskeletal 5
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0071840 (cellular component organization or biogenesis), GO:0045103 (intermediate filament-based process), GO:0007568 (aging), GO:0042303 (molting cycle), GO:0016043 (cellular component organization), GO:0042633 (hair cycle), GO:0009888 (tissue development), GO:0045104 (intermediate filament cytoskeleton organization), GO:0048513 (animal organ development), GO:0043588 (skin development), GO:0060429 (epithelium development), GO:0006996 (organelle organization), GO:0045109 (intermediate filament organization), GO:0008544 (epidermis development), GO:0097435 (supramolecular fiber organization), GO:0007010 (cytoskeleton organization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0099080 (supramolecular complex), GO:0099081 (supramolecular polymer), GO:0043229 (intracellular organelle), GO:0043228 (non-membrane-bounded organelle), GO:0043232 (intracellular non-membrane-bounded organelle), GO:0099512 (supramolecular fiber), GO:0005856 (cytoskeleton), GO:0099513 (polymeric cytoskeletal fiber), GO:0005882 (intermediate filament), GO:0045111 (intermediate filament cytoskeleton), GO:0045095 (keratin filament)
Protein: Complement C8 gamma chain (A0A8I6A491)
Organism: Rattus norvegicus (Rat)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MWTSGLCFLWHWTVDSDLEQCTPPPPCPITYCHRTAMLSPGAVLFFTLILMASSLGQRTRKPYGSTSPISTIQAQANFNAQQFAGTWLLVAVGSACRFLQEQGHRAEATTLHIAPQGAAMAASTFRKLDGICWQVRQLYGITGVPGRFLLQAPRARGPVHVVVAETDYQSFAILYLEQARRLSVKLYTRTLPVSDSALNAFEERVRGANLTEDQIFFFPKYVSGGVVCPRSGRQHLQERAPAFAAFLYHAVQAERQQ
InterPro domains: - IPR043245: Complement component C8 gamma chain (family) [18-221]
- IPR012674: Calycin (homologous_superfamily) [57-225]
- IPR000566: Lipocalin/cytosolic fatty-acid binding domain (domain) [84-220]
- IPR022272: Lipocalin family conserved site (conserved_site) [77-90]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0044877 (protein-containing complex binding), GO:0005515 (protein binding), GO:0001848 (complement binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0042221 (response to chemical), GO:0010033 (response to organic substance), GO:1901700 (response to oxygen-containing compound), GO:0009743 (response to carbohydrate), GO:0034284 (response to monosaccharide), GO:0009746 (response to hexose), GO:0009749 (response to glucose)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: GH19218p (No long nerve cord, isoform B (EC 3.4.24.-)) (Q9V9Q9)
Organism: Drosophila melanogaster (Fruit fly)
Function: Not known
Subcellular location: Secreted {ECO:0000256|ARBA:ARBA00004613}.
Sequence: MSVNMNWTSPKIWAALFVTTLCLLDTQAAWAKKLNASQAFDDTWNTASDLENELEQQKRSKVQSAGGGGGAGGGPGQWSSWSDWSTCSRTCDGGIMHQMRRCGSPGSCRGESTRYRICNMQPCPEQQDFRSSQCSAYNDVPYDGTLYKWTPHYDYVEPCALTCRGHPAHLVEDISRETGDGNAEEAEHYDEQSVIVQLSARVQDGTRCRSGSLDMCIQGKCQRVGCDLKIGSTKKIDGCGVCGGDGNSCSQPLFNWEMAPMSQCSVTCGSGYKMSRPICRNRLTNADVDDTLCSVTNRPEASVEQCNTHSCPPRWIADDWSTCSRLCGHGYRERMVVCAEESNGIKTRVADIMCRTPKPPTQETCIIEECPHWEVEDWTGCSVSCGQGIQMRGVECKSTDGSLSAKCDPLTKPGSMQQCSTGIHCGGSLNKVGGTIIVGSSRSLNERSERQLDSSDADEDNEDENDEGDDVDDLESGQDTDDGEGLSYADQPLLYAHRTQSRLNQEAPDEPRTMHLMNGNSNNNFNRGEDESEGPSLDPTYIKDNEWSPCSVTCGEGIRRRTYNCKIFLEYSRTVATVNDSLCEGKKPHDEVERCVEDPCMLPSHGFDDQFPRDSIKVGVSEPGKTYVWREQGYTSCSASCLGGVEELIINCVREDNGRVVSPFLCSPETKPEARVRTCNDRPCPPRWNYSDYTPCSKSCGIGIKTREVQCIHEVTRGGDNTMVVPNSMCPQPPPADRQYCNVLDCPVRWEVGEWSKCSHTCGYGFKDRKVECKQIMAQEHKIERPESMCPSAKPADKKPCNVKPCPPEDPKPVIQINNSTHIQHDPKKTKITLKVGGAGLVFFGTQVKIKCPVKRYNRTKIKWSKDHKPLQRSRKYKVSKKGALRILDITFRDAGVYSCHAGLSSAEISIEVKAKPGQQIEELEQQETERLVREKSGTEALTSADMKSADGTGTSTAVGPNSHVNGSAQQHGSRRRQQQSERLQNGRERSRRPKSDGVQHADSSIMEDDVEPF
InterPro domains: - IPR036179: Immunoglobulin-like domain superfamily (homologous_superfamily) [842-918]
- IPR013098: Immunoglobulin I-set (domain) [845-908]
- IPR013783: Immunoglobulin-like fold (homologous_superfamily) [816-917]
- IPR013273: ADAMTS/ADAMTS-like (family) [84-249]
- IPR007110: Immunoglobulin-like domain (domain) [827-910]
- IPR000884: Thrombospondin type-1 (TSP1) repeat (repeat) [75-807]
- IPR003598: Immunoglobulin subtype 2 (domain) [843-907]
- IPR050439: ADAMTS and ADAMTS-like (family) [72-250]
- IPR003599: Immunoglobulin domain subtype (domain) [837-914]
- IPR036383: Thrombospondin type-1 repeat superfamily (homologous_superfamily) [73-807]
- IPR045371: ADAMTS/ADAMTS-like, cysteine-rich domain 3 (domain) [192-249]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0032502 (developmental process), GO:0032501 (multicellular organismal process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048731 (system development), GO:0048513 (animal organ development), GO:0007417 (central nervous system development), GO:0007419 (ventral cord development), GO:0007399 (nervous system development)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005576 (extracellular region), GO:0005615 (extracellular space)
Protein: GrpE protein homolog 1, mitochondrial (Mt-GrpE#1) (Q99LP6)
Organism: Mus musculus (Mouse)
Function: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).
Subcellular location: Mitochondrion matrix {ECO:0000250}.
Sequence: MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA
InterPro domains: - IPR009012: GrpE nucleotide exchange factor, head (homologous_superfamily) [159-216]
- IPR013805: GrpE nucleotide exchange factor, coiled-coil (homologous_superfamily) [53-159]
- IPR000740: GrpE nucleotide exchange factor (family) [28-215]
Interaction partners: - Stress-70 protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM44
- Mitochondrial disaggregase
- Mitochondrial import inner membrane translocase subunit Tim23
- 10 kDa heat shock protein, mitochondrial
- Mitochondrial import inner membrane translocase subunit Tim17-A
- DnaJ homolog subfamily C member 15
- NADH dehydrogenase 1 alpha subcomplex subunit 9, mitochondrial
- Mitochondrial import inner membrane translocase subunit TIM16
- Large ribosomal subunit protein bL12m
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding), GO:0051082 (unfolded protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0050896 (response to stimulus), GO:0009987 (cellular process), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0006950 (response to stress), GO:0009408 (response to heat), GO:0009266 (response to temperature stimulus), GO:0033554 (cellular response to stress), GO:0034605 (cellular response to heat)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0031975 (envelope), GO:0016020 (membrane), GO:0005737 (cytoplasm), GO:0031090 (organelle membrane), GO:0031967 (organelle envelope), GO:0005739 (mitochondrion), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0005740 (mitochondrial envelope), GO:0019866 (organelle inner membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031966 (mitochondrial membrane), GO:0005743 (mitochondrial inner membrane)
Protein: LETM1 domain containing 1 (F8VVQ3)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004434}.
Sequence: MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSKLHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGIISIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLCTKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLR
InterPro domains: - IPR033122: LETM1-like, ribosome-binding domain (domain) [93-260]
- IPR044202: LETM1/MDM38-like (family) [93-260]
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0071840 (cellular component organization or biogenesis), GO:0016043 (cellular component organization), GO:0044085 (cellular component biogenesis), GO:0006996 (organelle organization), GO:0043933 (protein-containing complex organization), GO:0022607 (cellular component assembly), GO:0065003 (protein-containing complex assembly), GO:0007005 (mitochondrion organization), GO:0033108 (mitochondrial respiratory chain complex assembly), GO:0010257 (NADH dehydrogenase complex assembly), GO:0032981 (mitochondrial respiratory chain complex I assembly)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0005739 (mitochondrion), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle)