Protein: Angiomotin (Q8VHG2)
Organism: Mus musculus (Mouse)
Function: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity).
Subcellular location: Cell junction, tight junction {ECO:0000250}. Note=Localized on the cell surface. May act as a transmembrane protein (By similarity). {ECO:0000250}.
Sequence: MRSSDDQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGNSSPFSTGSGNQGPQNDVLSSQDHHQQQLVAHPARQEPQGQEIQSENGVMEKQLSPRMQNNEELPTYEEAKVQSQYFRGQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLTPGKMHQDEGLRDLKQGHVRSLSERLMQMSLATSGVKAHPPVTSAPLSPPQPNDLYKNATSSSEFYKAQGPPPSQHSLKGMEHRGPPPEYPFKGVPSQSVVCKSQEPGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARATQDISSLSLSARNSQPHSPTSSLTAGASSLPLLQSPPSTRLPPGQHLVSNQGDHSAHLSRHQQHLLSSQSHQGDHYRHAQASLTSAQQQPGEAYSAMPRAQQSASYQPMPADPFAMVSRAQQMVEILSDENRNLRQELDGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRDRLETANKQLAEKEYEGSEDTRKTISQLFAKHKENQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNSQPTNASEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSSMRPAKSLMSISNAGSGLLAHSSTLTGAPIMEEKRDDKSWKGSLGVLLGGDYRVEPVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGPESTKTAAVTPISAPMAGPVAAAAPAAAINATAATNTATAATNTTIMVAAAPVAVAAVAAPAAAAATPSPANAAALAAAAAPATSVSAATSVSAANSISPAAPVAPAAVVPPAAPVSPAAAVQIPAAASLTPATVSPTAATATAAVAAATTAAITAAAAAATTAIQVAPATSAPVPSPASIPAPATAQASAPTPTQASTPAPTEPPSPVPTPTPALVQTEGPANPGASSGPRRLSTPNLMCNPDKPDAPAFHSSTLERKTPIQILGQEPDAEMVEYLI
InterPro domains: - IPR009114: Angiomotin (family) [462-751]
- IPR051747: Angiomotin-like (family) [1-1126]
- IPR024646: Angiomotin, C-terminal (domain) [578-781]
Interaction partners: - InaD-like protein
- Rho GTPase-activating protein 17
- Protein PALS1
- Transcriptional coactivator YAP1
- WW domain-containing transcription regulator protein 1
- Merlin
- Plasminogen
- Serine/threonine-protein kinase LATS1
- Protein KIBRA
- Multiple PDZ domain protein
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0023052 (signaling), GO:0032501 (multicellular organismal process), GO:0065007 (biological regulation), GO:0050896 (response to stimulus), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0048869 (cellular developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0009653 (anatomical structure morphogenesis), GO:0071840 (cellular component organization or biogenesis), GO:0051241 (negative regulation of multicellular organismal process), GO:0051239 (regulation of multicellular organismal process), GO:0050793 (regulation of developmental process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0051716 (cellular response to stimulus), GO:0030029 (actin filament-based process), GO:0051093 (negative regulation of developmental process), GO:0007154 (cell communication), GO:0007165 (signal transduction), GO:0048522 (positive regulation of cellular process), GO:0032989 (cellular component morphogenesis), GO:0035556 (intracellular signal transduction), GO:0048468 (cell development), GO:0030154 (cell differentiation), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0048513 (animal organ development), GO:0051130 (positive regulation of cellular component organization), GO:0030036 (actin cytoskeleton organization), GO:0032970 (regulation of actin filament-based process), GO:0044089 (positive regulation of cellular component biogenesis), GO:1901343 (negative regulation of vasculature development), GO:0044087 (regulation of cellular component biogenesis), GO:0000902 (cell morphogenesis), GO:0010632 (regulation of epithelial cell migration), GO:2000026 (regulation of multicellular organismal development), GO:0016358 (dendrite development), GO:0045596 (negative regulation of cell differentiation), GO:0022603 (regulation of anatomical structure morphogenesis), GO:0045595 (regulation of cell differentiation), GO:0016043 (cellular component organization), GO:0051128 (regulation of cellular component organization), GO:0090066 (regulation of anatomical structure size), GO:0048638 (regulation of developmental growth), GO:0032535 (regulation of cellular component size), GO:0043254 (regulation of protein-containing complex assembly), GO:0030030 (cell projection organization), GO:0031344 (regulation of cell projection organization), GO:0032990 (cell part morphogenesis), GO:1901342 (regulation of vasculature development), GO:0090257 (regulation of muscle system process), GO:0048666 (neuron development), GO:0060491 (regulation of cell projection assembly), GO:0022008 (neurogenesis), GO:0000904 (cell morphogenesis involved in differentiation), GO:0007399 (nervous system development), GO:0031346 (positive regulation of cell projection organization), GO:1902905 (positive regulation of supramolecular fiber organization), GO:0120034 (positive regulation of plasma membrane bounded cell projection assembly), GO:0033043 (regulation of organelle organization), GO:0032956 (regulation of actin cytoskeleton organization), GO:0045765 (regulation of angiogenesis), GO:0007264 (small GTPase mediated signal transduction), GO:0006996 (organelle organization), GO:0048858 (cell projection morphogenesis), GO:0030182 (neuron differentiation), GO:2000181 (negative regulation of blood vessel morphogenesis), GO:0048667 (cell morphogenesis involved in neuron differentiation), GO:0120032 (regulation of plasma membrane bounded cell projection assembly), GO:0051493 (regulation of cytoskeleton organization), GO:0120035 (regulation of plasma membrane bounded cell projection organization), GO:0120039 (plasma membrane bounded cell projection morphogenesis), GO:0120036 (plasma membrane bounded cell projection organization), GO:0008361 (regulation of cell size), GO:0007010 (cytoskeleton organization), GO:0007265 (Ras protein signal transduction), GO:0031175 (neuron projection development), GO:0048699 (generation of neurons), GO:0110053 (regulation of actin filament organization), GO:0030838 (positive regulation of actin filament polymerization), GO:0032273 (positive regulation of protein polymerization), GO:0051495 (positive regulation of cytoskeleton organization), GO:0008064 (regulation of actin polymerization or depolymerization), GO:0048812 (neuron projection morphogenesis), GO:0061564 (axon development), GO:1902743 (regulation of lamellipodium organization), GO:0010591 (regulation of lamellipodium assembly), GO:0007409 (axonogenesis)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0045177 (apical part of cell), GO:0016020 (membrane), GO:0030054 (cell junction), GO:0005737 (cytoplasm), GO:0071944 (cell periphery), GO:0098590 (plasma membrane region), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0070161 (anchoring junction), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0016324 (apical plasma membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0031982 (vesicle), GO:0005911 (cell-cell junction), GO:0043296 (apical junction complex), GO:0070160 (tight junction), GO:0097708 (intracellular vesicle), GO:0005923 (bicellular tight junction)