Protein: T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2) (O43711)
Organism: Homo sapiens (Human)
Function: Not known
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MEAPASAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTSLV
InterPro domains: - IPR001356: Homeodomain (domain) [164-228]
- IPR020479: Homeodomain, metazoa (domain) [188-222]
- IPR042247: T-cell leukemia homeobox protein 1/2/3 (family) [6-288]
- IPR009057: Homedomain-like superfamily (homologous_superfamily) [153-224]
- IPR017970: Homeobox, conserved site (conserved_site) [199-222]
Interaction partners: - PHD finger protein 6
- Protein lyl-1
- Nuclear pore complex protein Nup214
- T-cell acute lymphocytic leukemia protein 1
- Rhombotin-1
- B-cell lymphoma/leukemia 11B
- Ran-binding protein 17
- Rhombotin-2
- Tyrosine-protein kinase ABL1
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0065007 (biological regulation), GO:0050789 (regulation of biological process), GO:0032502 (developmental process), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0032501 (multicellular organismal process), GO:0048869 (cellular developmental process), GO:0050793 (regulation of developmental process), GO:0048856 (anatomical structure development), GO:0007275 (multicellular organism development), GO:0048870 (cell motility), GO:0050794 (regulation of cellular process), GO:0007585 (respiratory gaseous exchange by respiratory system), GO:0051239 (regulation of multicellular organismal process), GO:0051093 (negative regulation of developmental process), GO:0048523 (negative regulation of cellular process), GO:0003008 (system process), GO:0045165 (cell fate commitment), GO:0030154 (cell differentiation), GO:0045596 (negative regulation of cell differentiation), GO:0048731 (system development), GO:0044057 (regulation of system process), GO:0001708 (cell fate specification), GO:0045595 (regulation of cell differentiation), GO:0050877 (nervous system process), GO:0043576 (regulation of respiratory gaseous exchange), GO:0016477 (cell migration), GO:0045664 (regulation of neuron differentiation), GO:0022008 (neurogenesis), GO:0048665 (neuron fate specification), GO:0007399 (nervous system development), GO:0001764 (neuron migration), GO:0048663 (neuron fate commitment), GO:0007417 (central nervous system development), GO:0045665 (negative regulation of neuron differentiation), GO:0030182 (neuron differentiation), GO:0097154 (GABAergic neuron differentiation), GO:0048699 (generation of neurons)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0043231 (intracellular membrane-bounded organelle), GO:0005634 (nucleus)