Protein: Polyadenylate-binding protein-interacting protein 12 (PABP-interacting protein 12) (Poly(A)-binding protein-interacting protein 12) (PAM2-containing protein CID12) (Protein CTC-INTERACTING DOMAIN 12) (RNA-binding protein 37) (AtRBP37) (Q9S7N9)
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Binds nucleotic acids in vitro.
Subcellular location: Nucleus {ECO:0000305}.
Sequence: MAVIESVGANTTVEAGGLISPSPPSSVTSQESGASSNNDHGGNGIHDEIGVHVARSDGGESFKRDMRELHELLSKLNPMAKEFIPPSLTKPVVNGFNGGFFAVNNGFVAAGNFPVNEDGSFRRKKSFGQQGKRRMNPRTSLAQREEIIRRTVYVSDIDQQVTEEQLAGLFIGFGQVVDCRICGDPNSVLRFAFIEFTDEVGARTALNLSGTMLGFYPVKVMPSKTAIAPVNPTFLPRTEDEREMCARTIYCTNIDKKLTQTDIKLFFESVCGEVYRLRLLGDYHHPTRIGFVEFVMAESAIAALNCSGVLLGSLPIRVSPSKTPVRSRAIPRHQMH
InterPro domains: - IPR035979: RNA-binding domain superfamily (homologous_superfamily) [139-332]
- IPR012677: Nucleotide-binding alpha-beta plait domain superfamily (homologous_superfamily) [114-329]
- IPR034825: CID8-like protein, RNA recognition motif 2 (domain) [243-324]
- IPR034823: CID8-like protein, RNA recognition motif 1 (domain) [148-227]
- IPR009818: PAM2 motif (conserved_site) [73-87]
- IPR000504: RNA recognition motif domain (domain) [150-323]
Interaction partners: - Polyadenylate-binding protein-interacting protein 2
- Polyadenylate-binding protein-interacting protein 3
- Ribosome assembly factor mrt4
- Polyadenylate-binding protein-interacting protein 6
- Polyadenylate-binding protein-interacting protein 5
- Polyadenylate-binding protein-interacting protein 7
- Polyadenylate-binding protein-interacting protein 4
- Protein EARLY RESPONSIVE TO DEHYDRATION 15
- Polyadenylate-binding protein 6
- Protein RDM16
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0097159 (organic cyclic compound binding), GO:1901363 (heterocyclic compound binding), GO:0003676 (nucleic acid binding), GO:0003723 (RNA binding), GO:0003729 (mRNA binding)
Biological Process (BP): GO:0008150 (biological process), GO:0051179 (localization), GO:0048518 (positive regulation of biological process), GO:0050789 (regulation of biological process), GO:0065007 (biological regulation), GO:0009987 (cellular process), GO:0048519 (negative regulation of biological process), GO:0051641 (cellular localization), GO:0019222 (regulation of metabolic process), GO:0051234 (establishment of localization), GO:0071840 (cellular component organization or biogenesis), GO:0033036 (macromolecule localization), GO:0009892 (negative regulation of metabolic process), GO:0065008 (regulation of biological quality), GO:0050794 (regulation of cellular process), GO:0009893 (positive regulation of metabolic process), GO:0048523 (negative regulation of cellular process), GO:0048522 (positive regulation of cellular process), GO:0051172 (negative regulation of nitrogen compound metabolic process), GO:0043487 (regulation of RNA stability), GO:0044085 (cellular component biogenesis), GO:0010604 (positive regulation of macromolecule metabolic process), GO:0051649 (establishment of localization in cell), GO:0060255 (regulation of macromolecule metabolic process), GO:0031324 (negative regulation of cellular metabolic process), GO:0045184 (establishment of protein localization), GO:0009894 (regulation of catabolic process), GO:0046907 (intracellular transport), GO:0031325 (positive regulation of cellular metabolic process), GO:0010605 (negative regulation of macromolecule metabolic process), GO:0006810 (transport), GO:0009889 (regulation of biosynthetic process), GO:0051171 (regulation of nitrogen compound metabolic process), GO:0051173 (positive regulation of nitrogen compound metabolic process), GO:0070727 (cellular macromolecule localization), GO:0031323 (regulation of cellular metabolic process), GO:0016043 (cellular component organization), GO:0009895 (negative regulation of catabolic process), GO:0080090 (regulation of primary metabolic process), GO:0071705 (nitrogen compound transport), GO:0010556 (regulation of macromolecule biosynthetic process), GO:0051246 (regulation of protein metabolic process), GO:0043488 (regulation of mRNA stability), GO:0072594 (establishment of protein localization to organelle), GO:0031330 (negative regulation of cellular catabolic process), GO:0051248 (negative regulation of protein metabolic process), GO:0071702 (organic substance transport), GO:0051169 (nuclear transport), GO:0010628 (positive regulation of gene expression), GO:0010468 (regulation of gene expression), GO:0022607 (cellular component assembly), GO:0045935 (positive regulation of nucleobase-containing compound metabolic process), GO:0051254 (positive regulation of RNA metabolic process), GO:0006886 (intracellular protein transport), GO:0034248 (regulation of amide metabolic process), GO:0043489 (RNA stabilization), GO:0015031 (protein transport), GO:0031326 (regulation of cellular biosynthetic process), GO:0019219 (regulation of nucleobase-containing compound metabolic process), GO:0043933 (protein-containing complex organization), GO:0008104 (protein localization), GO:0051252 (regulation of RNA metabolic process), GO:0031329 (regulation of cellular catabolic process), GO:0006996 (organelle organization), GO:0051253 (negative regulation of RNA metabolic process), GO:0045934 (negative regulation of nucleobase-containing compound metabolic process), GO:0010629 (negative regulation of gene expression), GO:0034249 (negative regulation of amide metabolic process), GO:1902373 (negative regulation of mRNA catabolic process), GO:0006913 (nucleocytoplasmic transport), GO:0033365 (protein localization to organelle), GO:0061013 (regulation of mRNA catabolic process), GO:1903312 (negative regulation of mRNA metabolic process), GO:0065003 (protein-containing complex assembly), GO:1903312 (negative regulation of mRNA metabolic process), GO:0061014 (positive regulation of mRNA catabolic process), GO:1902369 (negative regulation of RNA catabolic process), GO:0048255 (mRNA stabilization), GO:2000112 (regulation of cellular macromolecule biosynthetic process), GO:0006417 (regulation of translation), GO:1903311 (regulation of mRNA metabolic process), GO:2000113 (negative regulation of cellular macromolecule biosynthetic process), GO:1903313 (positive regulation of mRNA metabolic process), GO:0010608 (post-transcriptional regulation of gene expression), GO:0034504 (protein localization to nucleus), GO:0051170 (import into nucleus), GO:0070935 (3'-UTR-mediated mRNA stabilization)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0005737 (cytoplasm), GO:0043229 (intracellular organelle), GO:0043227 (membrane-bounded organelle), GO:0009536 (plastid), GO:0043231 (intracellular membrane-bounded organelle)