Protein: Protein PIEZO homolog (Q54S52)
Organism: Dictyostelium discoideum (Social amoeba)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence: MIGYFFVSLIYPFSLICSSVFRSNVVSYIYFIFFLLSILCLPHKSLILKNKISKTLPIITLVLSMFSLILQLLVNVVKVFQEQDELSVNILTAFGFYKYNSFWIVFRNVLPDVIVFVISLFTIILWFKNLVYPASINIKDSLKKTTSLNNVDQILNSPYVHGGSGNFNSGSNNNNNNNNIVYRPAGRGLTGFSFLMLTLSSISYPSIINVIYFVFTILIILLLASKLSIHKVMLKCYPILLITSLCHLLFVYLNQIEYFYMKYTVFKEQKWYGVLNYTEWDVTYWPLVIGYITVLLLYISTCILFRKQQLFNRTKPRYKQKLDKLGIMSDSNNNNNNNNKSRTTKLAIIFSKHGWTICCSQILVVCFFLTASVASAILLASGLICTLLPLKVFKKVIYIILLYFLVFISAQYIFNIPFSYSETDLQSYGLFSFNNSKWLYIGVQIVVSLTLSLYCFYSDIKDDDLGTIKKDQQSQQSQPQPQQQQQQQQSSQNNQIQQSPLQYQQPLPPTPISNKSLPSSPMSTKSTTVHIQNNNNGGGGGIIRPRKPLPPVPLGMIGKSSMAMTSNSSFGSNKPLNYIQQQQLQLQQQKVIGYQTSASINQLDINDSFSIAFPSLMLLTSGIGKGYDTFRGKYGGTFSKITSSLKAIAEITFLAIIGQSYRLALVGLFFCGLTSINLLNAGYMLFFIVFVISESLASRFWMCLIIYAQMVLLTLYIWQLSWISSYENDLTVLIGMTNYYGSPLWVGLIWHIIIITFSIIQWNVNKLYQRGLFSSSSSSSSSSNNNQNNNQNNQNNSYEDKFKNIPNFLLVFGDFIYRSVQQLSLPFCYLVIVIVSIFTKISLINIVYMATVFLCLLIHHISANGSIHIKRFWIIIILSQGVVLVARYIMQFNQVSHWLNSIFPKSNYISLSDIGLRNYSSSDRFIELFGCSSILVVCVFQLTVFFSIGQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLNTSNNNNQNNNNLIIKKYTFFDSLLYIVKRICYLHGPKFVLWMVFAISIAEYNFFNFIYLIMIVISMSFKKGTYRIGSFLLFYSQLWVLTQLAALLPTVQSFNSDKFFMDWVGLRQPNVSTPWDAVKLNLAIILVISIQQTSYWWNKEIQNEKLEIKKKKQLKKQQQQQRKLEEHEEEYEEEEDQFGNKKNNDKLSLLSNDSIEIILDDGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNQSNNENNENNNNSKKENLKKRLFWYISNFYELYGLECVFLVLAFALFWRLNILGMIYLIIIAVGLNIDKRNLHKLIYVSALLAPTILIQYLLILVVPTKENSYPWLDHPFFLNHKTIDNLLLLSIPDRYVLVIDFLVLFFSMLLFKQRNGYYLYKDFELHQQQQLNQQLNQQQHDSLKSIASSNSSSQKPLHPKNFFKFNSSIDGGDDDFTKEPRSWSNELRYMIIRYSSQVILIVIFLAGTAECDILSCFYVFFSVYVLFSGNAHSRKWSYLWKSLHIYNWLVLMAQIIFQVAVILYFQFKFNSNQMFEGHNHNHNHNHSSSSSSSSSGSIIDILSSQSSAIGIGGGNSSGSDSSYEVIENSLPTELYNIAVVFGFKIETGPLSISTISDVIIMVLLAYQKMIFQSRDFHILEEHLKAKRDLNYETAREFYKIRRNARIEQLNSIQDKITQRRSRLQHLKLKRINRRKNRHNHYYNNNPNNNYNNNNNNNNSNSSNSNNNNNDDDSNEPLSLGDNSFVPPKNTTNQNATNSTYSPFANSTMHMPPYENNNNNNNNNNNFNNNPLSNSSSTVSSFGVIEKPLEKKNWVKIYLNKILDWLDPLPDILIENYKKQQLQQQQKLEMNQSLLFGDQLQQEQQQQQEQQQQLNPQQQQSQSSKELPPILEQFEHNDDDFEISLNQAPGDYRNSIFIDSEQMRNAMQQMEQRRQQRLQQSIDASQLLQQQQQQQQASSSNTNTNSNNNNYNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNEIPKPNQTSSSTITLEPIEDEEEFLYKEKTQYFKRIIRGFSRIARDESKWLVFMACIANGVFYNSIISLVYLLAVFLYGRLFESPRPSKNFWRFMIGYSSLIICLKYVFQIPKNYYNCNENYHNSNNGTILMTSTSVYNTNNNINNNNQLNNNENYEWWQCPNTLLSEQNLLLTLPYVFGLYIIDGHFISGAFWDLAILLCCLWHRHVYRSKGLWNFQEKDFYVDQKQQSPLNLFNLDQQHFDQQQIDQIQNQQDLNNSPISLNSSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDQTLIDINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNIIIDQILVDCSNEYDEEDQQQFNEFYDEEFDDRNEQEKENDEQEIQVIKKSSKSIAKIIIYPFKWLFVSIIEYVWLAIRTDEKPGRDYYMPLLFTDFACLFFLVIFPQNFTGIPSSDIAEFLEQNVIPRQYIVILLAQFGVIILDRIIYLYKSVKAKFVLQIVLTVLYHVFLFFYFPDLIVKPFSFGYTWPLVVFYLMKCIYLYYSALQICYGYPILSQNRFLMDGYSDFHNIGYALYKAIPFVYELRTLLDWIATDTTMLFYDWLKFEDLYSTIFSVKCRLEWIKRQGRQKGHKQPKFEKFVTGVTFFIGLVILLWFPLIILSSGLPGSNIEPVNNIQIEVSVVGWNPFLKINQDLSLESGDGDSTMDQNSFNNLKEDYSFLTTDDRQGIQNISINTFSEEIWNLSPPAKAQLINYLLTNTSLQIEVSYTLTRSGGVNSVIVGSNSVQLKPDQELNFYNILTRVQSNNSNNSNNPNENSSSGSDDNNNNSNNNIGSNSFIVEGLFYKFIKLPGVSGNPIYPTDNNGNVLALDALFTMNSTNFNNSNQPPQYFWQVNAYDSTKTYNISTLESIQFYTISSKLPNGITSTLVSAGIIGLYVSVVLSVGRFLRLSITQISIKIQLENLDSCDEILKMIDDVFIAREYGDLVLEEELYHELIQVFRQPQLLYSLTTFKNNQLNLPTTPTINSTLNNQNNQNNNNNNNNNHEKIN
InterPro domains: - IPR056770: Piezo, THU9 and anchor domain (domain) [2455-2693]
- IPR056769: Piezo, TM1-24 (domain) [22-945]
- IPR031334: Piezo non-specific cation channel, cap domain (domain) [2736-3041]
- IPR056768: Piezo, transmembrane helical unit (domain) [2068-2237]
- IPR027272: Piezo family (family) [11-3046]
Interaction partners: - Timeless family protein
- Probable serine/threonine-protein kinase atr1
- Minichromosome loss protein Mcl1 middle region domain-containing protein
- BRCT domain-containing protein
- Cell division control protein 45 homolog
- DNA replication licensing factor MCM4
- Cell cycle checkpoint protein RAD17
- Component of 9-1-1 complex
- Cell cycle checkpoint protein RAD1
- DNA helicase
Gene Ontology annotations:
Molecular Function (MF): GO:0003674 (molecular function), GO:0005488 (binding), GO:0005515 (protein binding)
Biological Process (BP): GO:0008150 (biological process), GO:0009987 (cellular process), GO:0050896 (response to stimulus), GO:0009605 (response to external stimulus), GO:0051716 (cellular response to stimulus), GO:0009628 (response to abiotic stimulus), GO:0051606 (detection of stimulus), GO:0009581 (detection of external stimulus), GO:0009582 (detection of abiotic stimulus), GO:0104004 (cellular response to environmental stimulus), GO:0009612 (response to mechanical stimulus), GO:0071496 (cellular response to external stimulus), GO:0071214 (cellular response to abiotic stimulus), GO:0071260 (cellular response to mechanical stimulus), GO:0050982 (detection of mechanical stimulus)
Cellular Component (CC): GO:0005575 (cellular component), GO:0110165 (cellular anatomical entity), GO:0005622 (intracellular anatomical structure), GO:0043226 (organelle), GO:0042995 (cell projection), GO:0016020 (membrane), GO:0071944 (cell periphery), GO:0005737 (cytoplasm), GO:0012505 (endomembrane system), GO:0031090 (organelle membrane), GO:0120025 (plasma membrane bounded cell projection), GO:0031410 (cytoplasmic vesicle), GO:0043229 (intracellular organelle), GO:0005794 (Golgi apparatus), GO:0098590 (plasma membrane region), GO:0043227 (membrane-bounded organelle), GO:0005886 (plasma membrane), GO:0031253 (cell projection membrane), GO:0043231 (intracellular membrane-bounded organelle), GO:0005929 (cilium), GO:0098588 (bounding membrane of organelle), GO:0012506 (vesicle membrane), GO:0005798 (Golgi-associated vesicle), GO:0031982 (vesicle), GO:0030659 (cytoplasmic vesicle membrane), GO:0000139 (Golgi membrane), GO:0060170 (ciliary membrane), GO:0097708 (intracellular vesicle), GO:0030660 (Golgi-associated vesicle membrane)